---
OA_type: closed access
_id: '3536'
abstract:
- lang: eng
text: 'Genetic engineering of the mouse brain allows investigators to address novel
hypotheses in vivo. Because of the paucity of information on the network patterns
of the mouse hippocampus, we investigated the electrical patterns in the behaving
animal using multisite silicon probes and wire tetrodes. Theta (6-9 Hz) and gamma
(40-100 Hz) oscillations were present during exploration and rapid eye movement
sleep. Gamma power and theta power were comodulated and gamma power varied as
a function of the theta cycle. Pyramidal cells and putative interneurons were
phase-locked to theta oscillations. During immobility, consummatory behaviors
and slow-wave sleep, sharp waves were present in cornu ammonis region CA1 of the
hippocampus stratum radiatum associated with 140-200-Hz “ripples” in the pyramidal
cell layer and population burst of CA1 neurons. In the hilus, large-amplitude
“dentate spikes” occurred in association with increased discharge of hilar neurons.
The amplitude of field patterns was larger in the mouse than in the rat, likely
reflecting the higher neuron density in a smaller brain. We suggest that the main
hippocampal network patterns are mediated by similar pathways and mechanisms in
mouse and rat. '
article_processing_charge: No
article_type: original
author:
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
- first_name: Derek
full_name: Buhl, Derek
last_name: Buhl
- first_name: Kenneth
full_name: Harris, Kenneth
last_name: Harris
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Boldizsár
full_name: Czéh, Boldizsár
last_name: Czéh
- first_name: Alexei
full_name: Morozov, Alexei
last_name: Morozov
citation:
ama: Buzsáki G, Buhl D, Harris K, Csicsvari JL, Czéh B, Morozov A. Hippocampal network
patterns of activity in the mouse. Neuroscience. 2003;116(1):201-211. doi:10.1016/S0306-4522(02)00669-3
apa: Buzsáki, G., Buhl, D., Harris, K., Csicsvari, J. L., Czéh, B., & Morozov,
A. (2003). Hippocampal network patterns of activity in the mouse. Neuroscience.
Elsevier. https://doi.org/10.1016/S0306-4522(02)00669-3
chicago: Buzsáki, György, Derek Buhl, Kenneth Harris, Jozsef L Csicsvari, Boldizsár
Czéh, and Alexei Morozov. “Hippocampal Network Patterns of Activity in the Mouse.”
Neuroscience. Elsevier, 2003. https://doi.org/10.1016/S0306-4522(02)00669-3.
ieee: G. Buzsáki, D. Buhl, K. Harris, J. L. Csicsvari, B. Czéh, and A. Morozov,
“Hippocampal network patterns of activity in the mouse,” Neuroscience,
vol. 116, no. 1. Elsevier, pp. 201–211, 2003.
ista: Buzsáki G, Buhl D, Harris K, Csicsvari JL, Czéh B, Morozov A. 2003. Hippocampal
network patterns of activity in the mouse. Neuroscience. 116(1), 201–211.
mla: Buzsáki, György, et al. “Hippocampal Network Patterns of Activity in the Mouse.”
Neuroscience, vol. 116, no. 1, Elsevier, 2003, pp. 201–11, doi:10.1016/S0306-4522(02)00669-3.
short: G. Buzsáki, D. Buhl, K. Harris, J.L. Csicsvari, B. Czéh, A. Morozov, Neuroscience
116 (2003) 201–211.
date_created: 2018-12-11T12:03:50Z
date_published: 2003-01-15T00:00:00Z
date_updated: 2026-05-20T14:29:11Z
day: '15'
doi: 10.1016/S0306-4522(02)00669-3
extern: '1'
external_id:
pmid:
- '12535953'
intvolume: ' 116'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 201 - 211
pmid: 1
publication: Neuroscience
publication_identifier:
eissn:
- 1873-7544
issn:
- ' 0306-4522'
publication_status: published
publisher: Elsevier
publist_id: '2849'
quality_controlled: '1'
status: public
title: Hippocampal network patterns of activity in the mouse
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 116
year: '2003'
...
---
OA_place: publisher
OA_type: free access
_id: '3556'
abstract:
- lang: eng
text: We define the Morse-Smale complex of a Morse function over a 3-manifold as
the overlay of the descending and as- cending manifolds of all critical points.
In the generic case, its 3-dimensional cells are shaped like crystals and are
sepa- rated by quadrangular faces. In this paper, we give a combi- natorial algorithm
for constructing such complexes for piece- wise linear data.
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: John
full_name: Harer, John
last_name: Harer
- first_name: Vijay
full_name: Natarajan, Vijay
last_name: Natarajan
- first_name: Valerio
full_name: Pascucci, Valerio
last_name: Pascucci
citation:
ama: 'Edelsbrunner H, Harer J, Natarajan V, Pascucci V. Morse-Smale complexes for
piecewise linear 3-manifolds. In: Proceedings of the Nineteenth Annual Symposium
in Computional Geometry. Association for Computing Machinery; 2003:361-370.
doi:10.1145/777792.777846'
apa: 'Edelsbrunner, H., Harer, J., Natarajan, V., & Pascucci, V. (2003). Morse-Smale
complexes for piecewise linear 3-manifolds. In Proceedings of the nineteenth
annual symposium in Computional geometry (pp. 361–370). San Diego, CA, United
States: Association for Computing Machinery. https://doi.org/10.1145/777792.777846'
chicago: Edelsbrunner, Herbert, John Harer, Vijay Natarajan, and Valerio Pascucci.
“Morse-Smale Complexes for Piecewise Linear 3-Manifolds.” In Proceedings of
the Nineteenth Annual Symposium in Computional Geometry, 361–70. Association
for Computing Machinery, 2003. https://doi.org/10.1145/777792.777846.
ieee: H. Edelsbrunner, J. Harer, V. Natarajan, and V. Pascucci, “Morse-Smale complexes
for piecewise linear 3-manifolds,” in Proceedings of the nineteenth annual
symposium in Computional geometry, San Diego, CA, United States, 2003, pp.
361–370.
ista: 'Edelsbrunner H, Harer J, Natarajan V, Pascucci V. 2003. Morse-Smale complexes
for piecewise linear 3-manifolds. Proceedings of the nineteenth annual symposium
in Computional geometry. SCG: Symposium on Computational Geometry, 361–370.'
mla: Edelsbrunner, Herbert, et al. “Morse-Smale Complexes for Piecewise Linear 3-Manifolds.”
Proceedings of the Nineteenth Annual Symposium in Computional Geometry,
Association for Computing Machinery, 2003, pp. 361–70, doi:10.1145/777792.777846.
short: H. Edelsbrunner, J. Harer, V. Natarajan, V. Pascucci, in:, Proceedings of
the Nineteenth Annual Symposium in Computional Geometry, Association for Computing
Machinery, 2003, pp. 361–370.
conference:
end_date: 2003-10-26
location: San Diego, CA, United States
name: 'SCG: Symposium on Computational Geometry'
start_date: 2003-08-06
date_created: 2018-12-11T12:03:57Z
date_published: 2003-06-08T00:00:00Z
date_updated: 2026-05-20T14:15:30Z
day: '08'
doi: 10.1145/777792.777846
extern: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1145/777792.777846
month: '06'
oa: 1
oa_version: Accepted Version
page: 361 - 370
publication: Proceedings of the nineteenth annual symposium in Computional geometry
publication_identifier:
isbn:
- '9781581136630'
publication_status: published
publisher: Association for Computing Machinery
publist_id: '2829'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Morse-Smale complexes for piecewise linear 3-manifolds
type: conference
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2003'
...
---
OA_type: closed access
_id: '3543'
abstract:
- lang: eng
text: Both neocortical and hippocampal networks organize the firing patterns of
their neurons by prominent oscillations during sleep, but the functional role
of these rhythms is not well understood. Here, we show a robust correlation of
neuronal discharges between the somatosensory cortex and hippocampus on both slow
and fine time scales in the mouse and rat. Neuronal bursts in deep cortical layers,
associated with sleep spindles and delta waves/slow rhythm, effectively triggered
hippocampal discharges related to fast (ripple) oscillations. We hypothesize that
oscillation-mediated temporal links coordinate specific information transfer between
neocortical and hippocampal cell assemblies. Such a neocortical-hippocampal interplay
may be important for memory consolidation.
article_processing_charge: No
article_type: original
author:
- first_name: Anton
full_name: Sirota, Anton
last_name: Sirota
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Derek
full_name: Buhl, Derek
last_name: Buhl
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Sirota A, Csicsvari JL, Buhl D, Buzsáki G. Communication between neocortex
and hippocampus during sleep in rodents. PNAS. 2003;100(4):2065-2069. doi:10.1073/pnas.0437938100
apa: Sirota, A., Csicsvari, J. L., Buhl, D., & Buzsáki, G. (2003). Communication
between neocortex and hippocampus during sleep in rodents. PNAS. National
Academy of Sciences. https://doi.org/10.1073/pnas.0437938100
chicago: Sirota, Anton, Jozsef L Csicsvari, Derek Buhl, and György Buzsáki. “Communication
between Neocortex and Hippocampus during Sleep in Rodents.” PNAS. National
Academy of Sciences, 2003. https://doi.org/10.1073/pnas.0437938100.
ieee: A. Sirota, J. L. Csicsvari, D. Buhl, and G. Buzsáki, “Communication between
neocortex and hippocampus during sleep in rodents,” PNAS, vol. 100, no.
4. National Academy of Sciences, pp. 2065–2069, 2003.
ista: Sirota A, Csicsvari JL, Buhl D, Buzsáki G. 2003. Communication between neocortex
and hippocampus during sleep in rodents. PNAS. 100(4), 2065–2069.
mla: Sirota, Anton, et al. “Communication between Neocortex and Hippocampus during
Sleep in Rodents.” PNAS, vol. 100, no. 4, National Academy of Sciences,
2003, pp. 2065–69, doi:10.1073/pnas.0437938100.
short: A. Sirota, J.L. Csicsvari, D. Buhl, G. Buzsáki, PNAS 100 (2003) 2065–2069.
date_created: 2018-12-11T12:03:53Z
date_published: 2003-02-18T00:00:00Z
date_updated: 2026-05-20T14:20:24Z
day: '18'
doi: 10.1073/pnas.0437938100
extern: '1'
external_id:
pmid:
- '12576550'
intvolume: ' 100'
issue: '4'
language:
- iso: eng
month: '02'
oa_version: None
page: 2065 - 2069
pmid: 1
publication: PNAS
publication_identifier:
eissn:
- 1091-6490
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
publist_id: '2841'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Communication between neocortex and hippocampus during sleep in rodents
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 100
year: '2003'
...
---
OA_place: publisher
OA_type: free access
_id: '3528'
abstract:
- lang: eng
text: Gamma frequency oscillations (30-100 Hz) have been suggested to underlie various
cognitive and motor functions. Here, we examine the generation of gamma oscillation
currents in the hippocampus, using two-dimensional, 96-site silicon probes. Two
gamma generators were identified, one in the dentate gyrus and another in the
CA3-CA1 regions. The coupling strength between the two oscillators varied during
both theta and nontheta states. Both pyramidal cells and interneurons were phase-locked
to gamma waves. Anatomical connectivity, rather than physical distance, determined
the coupling strength of the oscillating neurons. CA3 pyramidal neurons discharged
CA3 and CA1 interneurons at latencies indicative of monosynaptic connections.
Intrahippocampal gamma oscillation emerges in the CA3 recurrent system, which
entrains the CA1 region via its interneurons.
article_processing_charge: No
article_type: original
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Brian
full_name: Jamieson, Brian
last_name: Jamieson
- first_name: Kensall
full_name: Wise, Kensall
last_name: Wise
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Jamieson B, Wise K, Buzsáki G. Mechanisms of gamma oscillations
in the hippocampus of the behaving rat. Neuron. 2003;37(2):311-322. doi:10.1016/S0896-6273(02)01169-8
apa: Csicsvari, J. L., Jamieson, B., Wise, K., & Buzsáki, G. (2003). Mechanisms
of gamma oscillations in the hippocampus of the behaving rat. Neuron. Elsevier.
https://doi.org/10.1016/S0896-6273(02)01169-8
chicago: Csicsvari, Jozsef L, Brian Jamieson, Kensall Wise, and György Buzsáki.
“Mechanisms of Gamma Oscillations in the Hippocampus of the Behaving Rat.” Neuron.
Elsevier, 2003. https://doi.org/10.1016/S0896-6273(02)01169-8.
ieee: J. L. Csicsvari, B. Jamieson, K. Wise, and G. Buzsáki, “Mechanisms of gamma
oscillations in the hippocampus of the behaving rat,” Neuron, vol. 37,
no. 2. Elsevier, pp. 311–322, 2003.
ista: Csicsvari JL, Jamieson B, Wise K, Buzsáki G. 2003. Mechanisms of gamma oscillations
in the hippocampus of the behaving rat. Neuron. 37(2), 311–322.
mla: Csicsvari, Jozsef L., et al. “Mechanisms of Gamma Oscillations in the Hippocampus
of the Behaving Rat.” Neuron, vol. 37, no. 2, Elsevier, 2003, pp. 311–22,
doi:10.1016/S0896-6273(02)01169-8.
short: J.L. Csicsvari, B. Jamieson, K. Wise, G. Buzsáki, Neuron 37 (2003) 311–322.
date_created: 2018-12-11T12:03:48Z
date_published: 2003-01-01T00:00:00Z
date_updated: 2026-05-21T07:50:07Z
day: '01'
doi: 10.1016/S0896-6273(02)01169-8
extern: '1'
external_id:
unknown:
- '12546825'
intvolume: ' 37'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/S0896-6273(02)01169-8
month: '01'
oa: 1
oa_version: Published Version
page: 311 - 322
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '2857'
quality_controlled: '1'
status: public
title: Mechanisms of gamma oscillations in the hippocampus of the behaving rat
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 37
year: '2003'
...
---
OA_type: closed access
_id: '3458'
article_processing_charge: No
author:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Klaus
full_name: Unsicker, Klaus
last_name: Unsicker
citation:
ama: 'Jonas PM, Unsicker K. Molekulare und zelluläre Grundlagen des Nervensystems.
In: Schmidt R, ed. Lehrbuch Vorklinik. Vol B. Deutscher Ärzteverlag; 2003:3-26.'
apa: Jonas, P. M., & Unsicker, K. (2003). Molekulare und zelluläre Grundlagen
des Nervensystems. In R. Schmidt (Ed.), Lehrbuch Vorklinik (Vol. B, pp.
3–26). Deutscher Ärzteverlag.
chicago: Jonas, Peter M, and Klaus Unsicker. “Molekulare und zelluläre Grundlagen
des Nervensystems.” In Lehrbuch Vorklinik, edited by R. Schmidt, B:3–26.
Deutscher Ärzteverlag, 2003.
ieee: P. M. Jonas and K. Unsicker, “Molekulare und zelluläre Grundlagen des Nervensystems,”
in Lehrbuch Vorklinik, vol. B, R. Schmidt, Ed. Deutscher Ärzteverlag, 2003,
pp. 3–26.
ista: 'Jonas PM, Unsicker K. 2003.Molekulare und zelluläre Grundlagen des Nervensystems.
In: Lehrbuch Vorklinik. vol. B, 3–26.'
mla: Jonas, Peter M., and Klaus Unsicker. “Molekulare und zelluläre Grundlagen des
Nervensystems.” Lehrbuch Vorklinik, edited by R. Schmidt, vol. B, Deutscher
Ärzteverlag, 2003, pp. 3–26.
short: P.M. Jonas, K. Unsicker, in:, R. Schmidt (Ed.), Lehrbuch Vorklinik, Deutscher
Ärzteverlag, 2003, pp. 3–26.
date_created: 2018-12-11T12:03:26Z
date_published: 2003-04-01T00:00:00Z
date_updated: 2026-05-21T08:48:31Z
day: '01'
editor:
- first_name: R.
full_name: Schmidt, R.
last_name: Schmidt
extern: '1'
language:
- iso: ger
month: '04'
oa_version: None
page: 3 - 26
publication: Lehrbuch Vorklinik
publication_identifier:
isbn:
- '9783769104431'
publication_status: published
publisher: Deutscher Ärzteverlag
publist_id: '2929'
status: public
title: Molekulare und zelluläre Grundlagen des Nervensystems
type: book_chapter
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: B
year: '2003'
...
---
OA_type: closed access
_id: '3425'
abstract:
- lang: eng
text: 'Recent observations of the polarization of the light emitted by supernova
explo-sions indicate that there are large deviations from spherical symmetry in
the very heart of these explosions. Asymmetries may well play a key role in the
explosion mechanism. So far there is no convincing theoretical explanation for
these observations. In this work the impact of angular momentum on the core collapse
which is possibly the origin of large asymmetries is studied. We introduce a new
approach to the supernova problem: a three dimensional test particle based simulation.
The infall phase of the collapse of a typical iron core is investigated using
numerical calculations. Our main focus is the impact of angular momentum. Significant
deviations from spherical symmetry are found for rapidly rotating supernova cores.'
alternative_title:
- Nato Science Series II
article_processing_charge: No
author:
- first_name: Mark Tobias
full_name: Bollenbach, Mark Tobias
id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
last_name: Bollenbach
orcid: 0000-0003-4398-476X
- first_name: T.
full_name: Strother, T.
last_name: Strother
- first_name: Wolfgang
full_name: Bauer, Wolfgang
last_name: Bauer
citation:
ama: 'Bollenbach MT, Strother T, Bauer W. 3D supernova collapse calculations. In:
Vol 166. Springer Nature; 2003:277-288. doi:10.1007/978-1-4020-2705-5_21'
apa: Bollenbach, M. T., Strother, T., & Bauer, W. (2003). 3D supernova collapse
calculations (Vol. 166, pp. 277–288). Presented at the NATO ASI on Structure and
Dynamics of Elementary Matter, Springer Nature. https://doi.org/10.1007/978-1-4020-2705-5_21
chicago: Bollenbach, Mark Tobias, T. Strother, and Wolfgang Bauer. “3D Supernova
Collapse Calculations,” 166:277–88. Springer Nature, 2003. https://doi.org/10.1007/978-1-4020-2705-5_21.
ieee: M. T. Bollenbach, T. Strother, and W. Bauer, “3D supernova collapse calculations,”
presented at the NATO ASI on Structure and Dynamics of Elementary Matter, 2003,
vol. 166, pp. 277–288.
ista: Bollenbach MT, Strother T, Bauer W. 2003. 3D supernova collapse calculations.
NATO ASI on Structure and Dynamics of Elementary Matter, Nato Science Series II,
vol. 166, 277–288.
mla: Bollenbach, Mark Tobias, et al. 3D Supernova Collapse Calculations.
Vol. 166, Springer Nature, 2003, pp. 277–88, doi:10.1007/978-1-4020-2705-5_21.
short: M.T. Bollenbach, T. Strother, W. Bauer, in:, Springer Nature, 2003, pp. 277–288.
conference:
name: NATO ASI on Structure and Dynamics of Elementary Matter
date_created: 2018-12-11T12:03:16Z
date_published: 2003-01-01T00:00:00Z
date_updated: 2026-05-21T11:46:24Z
day: '01'
doi: 10.1007/978-1-4020-2705-5_21
extern: '1'
intvolume: ' 166'
language:
- iso: eng
month: '01'
oa_version: None
page: 277 - 288
publication_identifier:
eisbn:
- '9781402027055'
isbn:
- '9781402024467'
publication_status: published
publisher: Springer Nature
publist_id: '2976'
quality_controlled: '1'
status: public
title: 3D supernova collapse calculations
type: conference
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 166
year: '2003'
...
---
OA_place: repository
OA_type: hybrid
_id: '3210'
abstract:
- lang: eng
text: 'Luby and Rackoff showed how to construct a (super-)pseudo-random permutation
{0,1}2n→ {0,1}2n from some number r of pseudo-random functions {0,1}n → {0,1}n.
Their construction, motivated by DES, consists of a cascade of r Feistel permutations.
A Feistel permutation 1for a pseudo-random function f is defined as (L, R) → (R,L
⊕ f (R)), where L and R are the left and right part of the input and ⊕ denotes
bitwise XOR or, in this paper, any other group operation on {0,1}n. The only non-trivial
step of the security proof consists of proving that the cascade of r Feistel permutations
with independent uniform random functions {0,1}n → {0,1}n, denoted Ψ2nr is indistinguishable
from a uniform random permutation {0,1}2n → {0,1}2n by any computationally unbounded
adaptive distinguisher making at most O(2cn) combined chosen plaintext/ciphertext
queries for any c < α, where a is a security parameter. Luby and Rackoff proved
α = 1/2 for r = 4. A natural problem, proposed by Pieprzyk is to improve on α
for larger r. The best known result, α = 3/4 for r = 6, is due to Patarin. In
this paper we prove a = 1 -O(1/r), i.e., the trivial upper bound α = 1 can be
approached. The proof uses some new techniques that can be of independent interest. '
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Ueli
full_name: Maurer, Ueli
last_name: Maurer
- first_name: Krzysztof Z
full_name: Pietrzak, Krzysztof Z
id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
last_name: Pietrzak
orcid: 0000-0002-9139-1654
citation:
ama: 'Maurer U, Pietrzak KZ. The security of many round Luby Rackoff pseudo random
permutations. In: Vol 2656. Springer Nature; 2003:544-561. doi:10.1007/3-540-39200-9_34'
apa: 'Maurer, U., & Pietrzak, K. Z. (2003). The security of many round Luby
Rackoff pseudo random permutations (Vol. 2656, pp. 544–561). Presented at the
EUROCRYPT: Theory and Applications of Cryptographic Techniques, Warschau, Polen:
Springer Nature. https://doi.org/10.1007/3-540-39200-9_34'
chicago: Maurer, Ueli, and Krzysztof Z Pietrzak. “The Security of Many Round Luby
Rackoff Pseudo Random Permutations,” 2656:544–61. Springer Nature, 2003. https://doi.org/10.1007/3-540-39200-9_34.
ieee: 'U. Maurer and K. Z. Pietrzak, “The security of many round Luby Rackoff pseudo
random permutations,” presented at the EUROCRYPT: Theory and Applications of Cryptographic
Techniques, Warschau, Polen, 2003, vol. 2656, pp. 544–561.'
ista: 'Maurer U, Pietrzak KZ. 2003. The security of many round Luby Rackoff pseudo
random permutations. EUROCRYPT: Theory and Applications of Cryptographic Techniques,
LNCS, vol. 2656, 544–561.'
mla: Maurer, Ueli, and Krzysztof Z. Pietrzak. The Security of Many Round Luby
Rackoff Pseudo Random Permutations. Vol. 2656, Springer Nature, 2003, pp.
544–61, doi:10.1007/3-540-39200-9_34.
short: U. Maurer, K.Z. Pietrzak, in:, Springer Nature, 2003, pp. 544–561.
conference:
end_date: 2003-05-08
location: Warschau, Polen
name: 'EUROCRYPT: Theory and Applications of Cryptographic Techniques'
start_date: 2003-05-04
date_created: 2018-12-11T12:02:02Z
date_published: 2003-06-04T00:00:00Z
date_updated: 2026-05-21T12:04:42Z
day: '04'
doi: 10.1007/3-540-39200-9_34
extern: '1'
intvolume: ' 2656'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://crypto-test.ethz.ch/publications/files/MauPie03.pdf
month: '06'
oa: 1
oa_version: Preprint
page: 544 - 561
publication_identifier:
isbn:
- '9783540140399'
- '9783540392002'
publication_status: published
publisher: Springer Nature
publist_id: '3473'
quality_controlled: '1'
status: public
title: The security of many round Luby Rackoff pseudo random permutations
type: conference
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 2656
year: '2003'
...
---
OA_place: publisher
OA_type: free access
_id: '3209'
abstract:
- lang: eng
text: We show that the fixed alphabet shortest common supersequence (SCS) and the
fixed alphabet longest common subsequence (LCS) problems parameterized in the
number of strings are W[1]-hard. Unless W[1]=FPT, this rules out the existence
of algorithms with time complexity of O(f(k)nα) for those problems. Here n is
the size of the problem instance, α is constant, k is the number of strings and
f is any function of k. The fixed alphabet version of the LCS problem is of particular
interest considering the importance of sequence comparison (e.g. multiple sequence
alignment) in the fixed length alphabet world of DNA and protein sequences.
article_processing_charge: No
article_type: original
author:
- first_name: Krzysztof Z
full_name: Pietrzak, Krzysztof Z
id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
last_name: Pietrzak
orcid: 0000-0002-9139-1654
citation:
ama: Pietrzak KZ. On the parameterized complexity of the fixed alphabet shortest
common supersequence and longest common subsequence problems. Journal of Computer
and System Sciences. 2003;67(4):757-771. doi:10.1016/S0022-0000(03)00078-3
apa: Pietrzak, K. Z. (2003). On the parameterized complexity of the fixed alphabet
shortest common supersequence and longest common subsequence problems. Journal
of Computer and System Sciences. Elsevier. https://doi.org/10.1016/S0022-0000(03)00078-3
chicago: Pietrzak, Krzysztof Z. “On the Parameterized Complexity of the Fixed Alphabet
Shortest Common Supersequence and Longest Common Subsequence Problems.” Journal
of Computer and System Sciences. Elsevier, 2003. https://doi.org/10.1016/S0022-0000(03)00078-3.
ieee: K. Z. Pietrzak, “On the parameterized complexity of the fixed alphabet shortest
common supersequence and longest common subsequence problems,” Journal of Computer
and System Sciences, vol. 67, no. 4. Elsevier, pp. 757–771, 2003.
ista: Pietrzak KZ. 2003. On the parameterized complexity of the fixed alphabet shortest
common supersequence and longest common subsequence problems. Journal of Computer
and System Sciences. 67(4), 757–771.
mla: Pietrzak, Krzysztof Z. “On the Parameterized Complexity of the Fixed Alphabet
Shortest Common Supersequence and Longest Common Subsequence Problems.” Journal
of Computer and System Sciences, vol. 67, no. 4, Elsevier, 2003, pp. 757–71,
doi:10.1016/S0022-0000(03)00078-3.
short: K.Z. Pietrzak, Journal of Computer and System Sciences 67 (2003) 757–771.
date_created: 2018-12-11T12:02:01Z
date_published: 2003-12-01T00:00:00Z
date_updated: 2026-05-21T11:50:33Z
day: '01'
doi: 10.1016/S0022-0000(03)00078-3
extern: '1'
intvolume: ' 67'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/S0022-0000(03)00078-3
month: '12'
oa: 1
oa_version: Accepted Version
page: 757 - 771
publication: Journal of Computer and System Sciences
publication_status: published
publisher: Elsevier
publist_id: '3472'
quality_controlled: '1'
status: public
title: On the parameterized complexity of the fixed alphabet shortest common supersequence
and longest common subsequence problems
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 67
year: '2003'
...
---
OA_place: repository
OA_type: green
_id: '3171'
abstract:
- lang: eng
text: 'Reconstructing a 3-D scene from more than one camera is a classical problem
in computer vision. One of the major sources of difficulty is the fact that not
all scene elements are visible from all cameras. In the last few years, two promising
approaches have been developed 11,12 that formulate the scene reconstruction problem
in terms of energy minimization, and minimize the energy using graph cuts. These
energy minimization approaches treat the input images symmetrically, handle visibility
constraints correctly, and allow spatial smoothness to be enforced. However, these
algorithm propose different problem formulations, and handle a limited class of
smoothness terms. One algorithm 11 uses a problem formulation that is restricted
to two-camera stereo, and imposes smoothness between a pair of cameras. The other
algorithm 12 can handle an arbitrary number of cameras, but imposes smoothness
only with respect to a single camera. In this paper we give a more general energy
minimization formulation for the problem, which allows a larger class of spatial
smoothness constraints. We show that our formulation includes both of the previous
approaches as special cases, as well as permitting new energy functions. Experimental
results on real data with ground truth are also included. '
alternative_title:
- Energy Minimization Methods in Computer Vision and Pattern Recognition
article_processing_charge: No
author:
- first_name: Vladimir
full_name: Kolmogorov, Vladimir
id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87
last_name: Kolmogorov
- first_name: Ramin
full_name: Zabih, Ramin
last_name: Zabih
- first_name: Steven
full_name: Gortler, Steven
last_name: Gortler
citation:
ama: 'Kolmogorov V, Zabih R, Gortler S. Generalized multi camera scene reconstruction
using graph cuts. In: 4th International Workshop. Vol 2683. Springer Nature;
2003:501-516. doi:10.1007/978-3-540-45063-4_32'
apa: 'Kolmogorov, V., Zabih, R., & Gortler, S. (2003). Generalized multi camera
scene reconstruction using graph cuts. In 4th International Workshop (Vol.
2683, pp. 501–516). Lisbon, Portugal: Springer Nature. https://doi.org/10.1007/978-3-540-45063-4_32'
chicago: Kolmogorov, Vladimir, Ramin Zabih, and Steven Gortler. “Generalized Multi
Camera Scene Reconstruction Using Graph Cuts.” In 4th International Workshop,
2683:501–16. Springer Nature, 2003. https://doi.org/10.1007/978-3-540-45063-4_32.
ieee: V. Kolmogorov, R. Zabih, and S. Gortler, “Generalized multi camera scene reconstruction
using graph cuts,” in 4th International Workshop, Lisbon, Portugal, 2003,
vol. 2683, pp. 501–516.
ista: 'Kolmogorov V, Zabih R, Gortler S. 2003. Generalized multi camera scene reconstruction
using graph cuts. 4th International Workshop. EMMCVPR: Energy Minimization Methods
in Computer Vision and Pattern Recognition, Energy Minimization Methods in Computer
Vision and Pattern Recognition, vol. 2683, 501–516.'
mla: Kolmogorov, Vladimir, et al. “Generalized Multi Camera Scene Reconstruction
Using Graph Cuts.” 4th International Workshop, vol. 2683, Springer Nature,
2003, pp. 501–16, doi:10.1007/978-3-540-45063-4_32.
short: V. Kolmogorov, R. Zabih, S. Gortler, in:, 4th International Workshop, Springer
Nature, 2003, pp. 501–516.
conference:
end_date: 2003-07-09
location: Lisbon, Portugal
name: 'EMMCVPR: Energy Minimization Methods in Computer Vision and Pattern Recognition'
start_date: 2003-07-07
date_created: 2018-12-11T12:01:48Z
date_published: 2003-06-26T00:00:00Z
date_updated: 2026-05-21T13:04:17Z
day: '26'
doi: 10.1007/978-3-540-45063-4_32
extern: '1'
intvolume: ' 2683'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.cs.cornell.edu/~rdz/Papers/KZG-EMMCVPR03.pdf
month: '06'
oa: 1
oa_version: Preprint
page: 501 - 516
publication: 4th International Workshop
publication_identifier:
eisbn:
- '9783540450634'
isbn:
- '9783540404989'
publication_status: published
publisher: Springer Nature
publist_id: '3512'
quality_controlled: '1'
status: public
title: Generalized multi camera scene reconstruction using graph cuts
type: conference
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 2683
year: '2003'
...
---
OA_type: closed access
_id: '3150'
abstract:
- lang: eng
text: Tripartite G-protein-coupled receptors (GPCRs) represent one of the largest
groups of signal transducers, transmitting signals from hormones, neuropeptides,
odorants, food and light. Ligand-bound receptors catalyse GDP/GTP exchange on
the G-protein α-subunit (Gα), leading to α-GTP separation from the βγ subunits
and pathway activation. Activating mutations in the receptors or G proteins underlie
many human diseases, including some cancers, dwarfism and premature puberty. Regulators
of G-protein signalling (RGS proteins) are known to modulate the level and duration
of ligand-induced signalling by accelerating the intrinsic GTPase activity of
the Gα subunit, and thus reformation of the inactive GDP-bound Gα. Here we find
that even in the absence of receptor, mutation of the RGS family member Sst2 (refs
6-9) permits spontaneous activation of the G-protein-coupled mating pathway in
Saccharomyces cerevisiae at levels normally seen only in the presence of ligand.
Our work demonstrates the occurence of spontaneous tripartite G-protein signalling
in vivo and identifies a requirement for RGS proteins in preventing such receptor-independent
activation.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
- first_name: David
full_name: Drubin, David
last_name: Drubin
citation:
ama: Siekhaus DE, Drubin D. Spontaneous receptor-independent heterotrimeric G-protein
signalling in an RGS mutant. Nature Cell Biology. 2003;5(3):231-235. doi:10.1038/ncb941
apa: Siekhaus, D. E., & Drubin, D. (2003). Spontaneous receptor-independent
heterotrimeric G-protein signalling in an RGS mutant. Nature Cell Biology.
Springer Nature. https://doi.org/10.1038/ncb941
chicago: Siekhaus, Daria E, and David Drubin. “Spontaneous Receptor-Independent
Heterotrimeric G-Protein Signalling in an RGS Mutant.” Nature Cell Biology.
Springer Nature, 2003. https://doi.org/10.1038/ncb941.
ieee: D. E. Siekhaus and D. Drubin, “Spontaneous receptor-independent heterotrimeric
G-protein signalling in an RGS mutant,” Nature Cell Biology, vol. 5, no.
3. Springer Nature, pp. 231–235, 2003.
ista: Siekhaus DE, Drubin D. 2003. Spontaneous receptor-independent heterotrimeric
G-protein signalling in an RGS mutant. Nature Cell Biology. 5(3), 231–235.
mla: Siekhaus, Daria E., and David Drubin. “Spontaneous Receptor-Independent Heterotrimeric
G-Protein Signalling in an RGS Mutant.” Nature Cell Biology, vol. 5, no.
3, Springer Nature, 2003, pp. 231–35, doi:10.1038/ncb941.
short: D.E. Siekhaus, D. Drubin, Nature Cell Biology 5 (2003) 231–235.
date_created: 2018-12-11T12:01:41Z
date_published: 2003-03-01T00:00:00Z
date_updated: 2026-05-21T13:51:51Z
day: '01'
doi: 10.1038/ncb941
extern: '1'
external_id:
pmid:
- '12598904 '
intvolume: ' 5'
issue: '3'
language:
- iso: eng
month: '03'
oa_version: None
page: 231 - 235
pmid: 1
publication: Nature Cell Biology
publication_identifier:
eissn:
- 1476-4679
issn:
- 1465-7392
publication_status: published
publisher: Springer Nature
publist_id: '3544'
quality_controlled: '1'
status: public
title: Spontaneous receptor-independent heterotrimeric G-protein signalling in an
RGS mutant
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 5
year: '2003'
...
---
OA_type: closed access
_id: '3151'
abstract:
- lang: eng
text: Biosynthesis of most peptide hormones and neuropeptides requires proteolytic
excision of the active peptide from inactive proprotein precursors, an activity
carried out by subtilisin-like proprotein convertases (SPCs) in constitutive or
regulated secretory pathways. The Drosophila amontillado (amon) gene encodes a
homolog of the mammalian PC2 protein, an SPC that functions in the regulated secretory
pathway in neuroendocrine tissues. We have identified amon mutants by isolating
ethylmethanesulfonate (EMS)-induced lethal and visible mutations that define two
complementation groups in the amon interval at 97D1 of the third chromosome. DNA
sequencing identified the amon complementation group and the DNA sequence change
for each of the nine amon alleles isolated. amon mutants display partial embryonic
lethality, are defective in larval growth, and arrest during the first to second
instar larval molt. Mutant larvae can be rescued by heat-shock-induced expression
of the amon protein. Rescued larvae arrest at the subsequent larval molt, suggesting
that amon is also required for the second to third instar larval molt. Our data
indicate that the amon proprotein convertase is required during embryogenesis
and larval development in Drosophila and support the hypothesis that AMON acts
to proteolytically process peptide hormones that regulate hatching, larval growth,
and larval ecdysis.
article_processing_charge: No
article_type: original
author:
- first_name: Lowell
full_name: Rayburn, Lowell
last_name: Rayburn
- first_name: Holly
full_name: Gooding, Holly
last_name: Gooding
- first_name: Semil
full_name: Choksi, Semil
last_name: Choksi
- first_name: Dhea
full_name: Maloney, Dhea
last_name: Maloney
- first_name: Ambrose
full_name: Kidd, Ambrose
last_name: Kidd
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
- first_name: Michael
full_name: Bender, Michael
last_name: Bender
citation:
ama: Rayburn L, Gooding H, Choksi S, et al. Amontillado, the Drosophila homolog
of the prohormone processing protease PC2, is required during embryogenesis and
early larval development. Genetics. 2003;163(1):227-237. doi:10.1093/genetics/163.1.227
apa: Rayburn, L., Gooding, H., Choksi, S., Maloney, D., Kidd, A., Siekhaus, D. E.,
& Bender, M. (2003). Amontillado, the Drosophila homolog of the prohormone
processing protease PC2, is required during embryogenesis and early larval development.
Genetics. Oxford Academic. https://doi.org/10.1093/genetics/163.1.227
chicago: Rayburn, Lowell, Holly Gooding, Semil Choksi, Dhea Maloney, Ambrose Kidd,
Daria E Siekhaus, and Michael Bender. “Amontillado, the Drosophila Homolog of
the Prohormone Processing Protease PC2, Is Required during Embryogenesis and Early
Larval Development.” Genetics. Oxford Academic, 2003. https://doi.org/10.1093/genetics/163.1.227.
ieee: L. Rayburn et al., “Amontillado, the Drosophila homolog of the prohormone
processing protease PC2, is required during embryogenesis and early larval development,”
Genetics, vol. 163, no. 1. Oxford Academic, pp. 227–237, 2003.
ista: Rayburn L, Gooding H, Choksi S, Maloney D, Kidd A, Siekhaus DE, Bender M.
2003. Amontillado, the Drosophila homolog of the prohormone processing protease
PC2, is required during embryogenesis and early larval development. Genetics.
163(1), 227–237.
mla: Rayburn, Lowell, et al. “Amontillado, the Drosophila Homolog of the Prohormone
Processing Protease PC2, Is Required during Embryogenesis and Early Larval Development.”
Genetics, vol. 163, no. 1, Oxford Academic, 2003, pp. 227–37, doi:10.1093/genetics/163.1.227.
short: L. Rayburn, H. Gooding, S. Choksi, D. Maloney, A. Kidd, D.E. Siekhaus, M.
Bender, Genetics 163 (2003) 227–237.
date_created: 2018-12-11T12:01:41Z
date_published: 2003-01-01T00:00:00Z
date_updated: 2026-05-22T08:38:04Z
day: '01'
doi: 10.1093/genetics/163.1.227
extern: '1'
external_id:
pmid:
- '12586710'
intvolume: ' 163'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 227 - 237
pmid: 1
publication: Genetics
publication_identifier:
eissn:
- 1943-2631
issn:
- 0016-6731
publication_status: published
publisher: Oxford Academic
publist_id: '3545'
quality_controlled: '1'
status: public
title: Amontillado, the Drosophila homolog of the prohormone processing protease PC2,
is required during embryogenesis and early larval development
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 163
year: '2003'
...
---
OA_place: publisher
OA_type: free access
_id: '2996'
abstract:
- lang: eng
text: "Plants, compared to animals, exhibit an amazing adaptability and plasticity
in their development. This is largely dependent on the ability of plants to form
new organs, such as lateral roots, leaves, and flowers during postembryonic development.
Organ primordia develop from founder cell populations into organs by coordinated
cell division and differentiation. Here, we show that organ formation in Arabidopsis
involves dynamic gradients of the signaling molecule auxin with maxima at the
primordia tips. These gradients are mediated by cellular efflux requiring asymmetrically
localized PIN proteins, which represent a functionally redundant network for auxin
distribution in both aerial and underground organs. PIN1 polar localization undergoes
a dynamic rearrangement, which correlates with establishment of auxin gradients
and primordium development. Our results suggest that PIN-dependent, local auxin
gradients represent a common module for formation of all plant organs, regardless
of their mature morphology or developmental origin.\r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Marta
full_name: Michniewicz, Marta
last_name: Michniewicz
- first_name: Michael
full_name: Sauer, Michael
last_name: Sauer
- first_name: Thomas
full_name: Teichmann, Thomas
last_name: Teichmann
- first_name: Daniela
full_name: Seifertová, Daniela
last_name: Seifertová
- first_name: Gerd
full_name: Jürgens, Gerd
last_name: Jürgens
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Benková E, Michniewicz M, Sauer M, et al. Local, efflux-dependent auxin gradients
as a common module for plant organ formation. Cell. 2003;115(5):591-602.
doi:10.1016/S0092-8674(03)00924-3
apa: Benková, E., Michniewicz, M., Sauer, M., Teichmann, T., Seifertová, D., Jürgens,
G., & Friml, J. (2003). Local, efflux-dependent auxin gradients as a common
module for plant organ formation. Cell. Cell Press. https://doi.org/10.1016/S0092-8674(03)00924-3
chicago: Benková, Eva, Marta Michniewicz, Michael Sauer, Thomas Teichmann, Daniela
Seifertová, Gerd Jürgens, and Jiří Friml. “Local, Efflux-Dependent Auxin Gradients
as a Common Module for Plant Organ Formation.” Cell. Cell Press, 2003.
https://doi.org/10.1016/S0092-8674(03)00924-3.
ieee: E. Benková et al., “Local, efflux-dependent auxin gradients as a common
module for plant organ formation,” Cell, vol. 115, no. 5. Cell Press, pp.
591–602, 2003.
ista: Benková E, Michniewicz M, Sauer M, Teichmann T, Seifertová D, Jürgens G, Friml
J. 2003. Local, efflux-dependent auxin gradients as a common module for plant
organ formation. Cell. 115(5), 591–602.
mla: Benková, Eva, et al. “Local, Efflux-Dependent Auxin Gradients as a Common Module
for Plant Organ Formation.” Cell, vol. 115, no. 5, Cell Press, 2003, pp.
591–602, doi:10.1016/S0092-8674(03)00924-3.
short: E. Benková, M. Michniewicz, M. Sauer, T. Teichmann, D. Seifertová, G. Jürgens,
J. Friml, Cell 115 (2003) 591–602.
date_created: 2018-12-11T12:00:46Z
date_published: 2003-11-26T00:00:00Z
date_updated: 2026-05-22T08:47:43Z
day: '26'
doi: 10.1016/S0092-8674(03)00924-3
extern: '1'
external_id:
pmid:
- '14651850'
intvolume: ' 115'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/S0092-8674(03)00924-3
month: '11'
oa: 1
oa_version: Published Version
page: 591 - 602
pmid: 1
publication: Cell
publication_identifier:
eissn:
- 1097-4172
issn:
- 0092-8674
publication_status: published
publisher: Cell Press
publist_id: '3706'
quality_controlled: '1'
status: public
title: Local, efflux-dependent auxin gradients as a common module for plant organ
formation
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 115
year: '2003'
...
---
OA_type: closed access
_id: '2992'
abstract:
- lang: eng
text: Plants have many polarized cell types, but relatively little is known about
the mechanisms that establish polarity. The orc mutant was identified originally
by defects in root patterning, and positional cloning revealed that the affected
gene encodes STEROL METHYLTRANSFERASE1, which is required for the appropriate
synthesis and composition of major membrane sterols. smt1orc mutants displayed
several conspicuous cell polarity defects. Columella root cap cells revealed perturbed
polar positioning of different organelles, and in the smt1orc root epidermis,
polar initiation of root hairs was more randomized. Polar auxin transport and
expression of the auxin reporter DR5-β-glucuronidase were aberrant in smt1orc.
Patterning defects in smt1orc resembled those observed in mutants of the PIN gene
family of putative auxin efflux transporters. Consistently, the membrane localization
of the PIN1 and PIN3 proteins was disturbed in smt1orc, whereas polar positioning
of the influx carrier AUX1 appeared normal. Our results suggest that balanced
sterol composition is a major requirement for cell polarity and auxin efflux in
Arabidopsis.
article_processing_charge: No
article_type: original
author:
- first_name: Viola
full_name: Willemsen, Viola
last_name: Willemsen
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Markus
full_name: Grebe, Markus
last_name: Grebe
- first_name: Albert
full_name: Van Den Toorn, Albert
last_name: Van Den Toorn
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
- first_name: Ben
full_name: Scheres, Ben
last_name: Scheres
citation:
ama: Willemsen V, Friml J, Grebe M, Van Den Toorn A, Palme K, Scheres B. Cell polarity
and PIN protein positioning in Arabidopsis require STEROL METHYLTRANSFERASE1 function.
Plant Cell. 2003;15(3):612-625. doi:10.1105/tpc.008433
apa: Willemsen, V., Friml, J., Grebe, M., Van Den Toorn, A., Palme, K., & Scheres,
B. (2003). Cell polarity and PIN protein positioning in Arabidopsis require STEROL
METHYLTRANSFERASE1 function. Plant Cell. American Society of Plant Biologists.
https://doi.org/10.1105/tpc.008433
chicago: Willemsen, Viola, Jiří Friml, Markus Grebe, Albert Van Den Toorn, Klaus
Palme, and Ben Scheres. “Cell Polarity and PIN Protein Positioning in Arabidopsis
Require STEROL METHYLTRANSFERASE1 Function.” Plant Cell. American Society
of Plant Biologists, 2003. https://doi.org/10.1105/tpc.008433.
ieee: V. Willemsen, J. Friml, M. Grebe, A. Van Den Toorn, K. Palme, and B. Scheres,
“Cell polarity and PIN protein positioning in Arabidopsis require STEROL METHYLTRANSFERASE1
function,” Plant Cell, vol. 15, no. 3. American Society of Plant Biologists,
pp. 612–625, 2003.
ista: Willemsen V, Friml J, Grebe M, Van Den Toorn A, Palme K, Scheres B. 2003.
Cell polarity and PIN protein positioning in Arabidopsis require STEROL METHYLTRANSFERASE1
function. Plant Cell. 15(3), 612–625.
mla: Willemsen, Viola, et al. “Cell Polarity and PIN Protein Positioning in Arabidopsis
Require STEROL METHYLTRANSFERASE1 Function.” Plant Cell, vol. 15, no. 3,
American Society of Plant Biologists, 2003, pp. 612–25, doi:10.1105/tpc.008433.
short: V. Willemsen, J. Friml, M. Grebe, A. Van Den Toorn, K. Palme, B. Scheres,
Plant Cell 15 (2003) 612–625.
date_created: 2018-12-11T12:00:44Z
date_published: 2003-03-01T00:00:00Z
date_updated: 2026-05-22T09:04:01Z
day: '01'
doi: 10.1105/tpc.008433
extern: '1'
external_id:
pmid:
- '12615936'
intvolume: ' 15'
issue: '3'
language:
- iso: eng
month: '03'
oa_version: None
page: 612 - 625
pmid: 1
publication: Plant Cell
publication_identifier:
eissn:
- 1532-298X
issn:
- 1040-4651
publication_status: published
publisher: American Society of Plant Biologists
publist_id: '3710'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cell polarity and PIN protein positioning in Arabidopsis require STEROL METHYLTRANSFERASE1
function
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 15
year: '2003'
...
---
OA_type: closed access
_id: '2994'
abstract:
- lang: eng
text: The regular arrangement of leaves around a plant's stem, called phyllotaxis,
has for centuries attracted the attention of philosophers, mathematicians and
natural scientists; however, to date, studies of phyllotaxis have been largely
theoretical. Leaves and flowers are formed from the shoot apical meristem, triggered
by the plant hormone auxin. Auxin is transported through plant tissues by specific
cellular influx and efflux carrier proteins. Here we show that proteins involved
in auxin transport regulate phyllotaxis. Our data indicate that auxin is transported
upwards into the meristem through the epidermis and the outermost meristem cell
layer. Existing leaf primordia act as sinks, redistributing auxin and creating
its heterogeneous distribution in the meristem. Auxin accumulation occurs only
at certain minimal distances from existing primordia, defining the position of
future primordia. This model for phyllotaxis accounts for its reiterative nature,
as well as its regularity and stability.
article_processing_charge: No
article_type: original
author:
- first_name: Didier
full_name: Reinhardt, Didier
last_name: Reinhardt
- first_name: Eva
full_name: Pesce, Eva
last_name: Pesce
- first_name: Pia
full_name: Stieger, Pia
last_name: Stieger
- first_name: Therese
full_name: Mandel, Therese
last_name: Mandel
- first_name: Kurt
full_name: Baltensperger, Kurt
last_name: Baltensperger
- first_name: Malcolm
full_name: Bennett, Malcolm
last_name: Bennett
- first_name: Jan
full_name: Traas, Jan
last_name: Traas
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Cris
full_name: Kuhlemeier, Cris
last_name: Kuhlemeier
citation:
ama: Reinhardt D, Pesce E, Stieger P, et al. Regulation of phyllotaxis by polar
auxin transport. Nature. 2003;426:255-260. doi:10.1038/nature02081
apa: Reinhardt, D., Pesce, E., Stieger, P., Mandel, T., Baltensperger, K., Bennett,
M., … Kuhlemeier, C. (2003). Regulation of phyllotaxis by polar auxin transport.
Nature. Springer Nature. https://doi.org/10.1038/nature02081
chicago: Reinhardt, Didier, Eva Pesce, Pia Stieger, Therese Mandel, Kurt Baltensperger,
Malcolm Bennett, Jan Traas, Jiří Friml, and Cris Kuhlemeier. “Regulation of Phyllotaxis
by Polar Auxin Transport.” Nature. Springer Nature, 2003. https://doi.org/10.1038/nature02081.
ieee: D. Reinhardt et al., “Regulation of phyllotaxis by polar auxin transport,”
Nature, vol. 426. Springer Nature, pp. 255–260, 2003.
ista: Reinhardt D, Pesce E, Stieger P, Mandel T, Baltensperger K, Bennett M, Traas
J, Friml J, Kuhlemeier C. 2003. Regulation of phyllotaxis by polar auxin transport.
Nature. 426, 255–260.
mla: Reinhardt, Didier, et al. “Regulation of Phyllotaxis by Polar Auxin Transport.”
Nature, vol. 426, Springer Nature, 2003, pp. 255–60, doi:10.1038/nature02081.
short: D. Reinhardt, E. Pesce, P. Stieger, T. Mandel, K. Baltensperger, M. Bennett,
J. Traas, J. Friml, C. Kuhlemeier, Nature 426 (2003) 255–260.
date_created: 2018-12-11T12:00:45Z
date_published: 2003-11-20T00:00:00Z
date_updated: 2026-05-22T08:55:25Z
day: '20'
doi: 10.1038/nature02081
extern: '1'
external_id:
pmid:
- '14628043'
intvolume: ' 426'
language:
- iso: eng
month: '11'
oa_version: None
page: 255 - 260
pmid: 1
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
publist_id: '3707'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Regulation of phyllotaxis by polar auxin transport
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 426
year: '2003'
...
---
OA_type: closed access
_id: '2993'
abstract:
- lang: eng
text: Plant biology is currently experiencing a growing demand for easy and reliable
mRNA and protein localisation techniques. Here, we present novel whole mount in
situ hybridisation and immunolocalisation protocols, suitable to localise mRNAs
and proteins in Arabidopsis seedlings. We demonstrate that these methods can be
used in different organs of Arabidopsis seedlings as well as in other plant species.
In order to achieve better reproducibility and higher throughput, we modified
these protocols for automation to be performed by a liquid handling robot. In
addition, we show that other procedures such as reporter enzyme assays and tissue
clearing can be similarly automated. We present examples of application of our
protocols including mRNA localisation and proteins and epitope tag (co)localisations
which demonstrate that these methods provide reliable and versatile tools for
expression, localisation and anatomical studies in plants.
article_processing_charge: No
article_type: original
author:
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Ulrike
full_name: Mayer, Ulrike
last_name: Mayer
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
- first_name: Gerhard
full_name: Muster, Gerhard
last_name: Muster
citation:
ama: Friml J, Benková E, Mayer U, Palme K, Muster G. Automated whole mount localisation
techniques for plant seedlings. Plant Journal. 2003;34(1):115-124. doi:10.1046/j.1365-313X.2003.01705.x
apa: Friml, J., Benková, E., Mayer, U., Palme, K., & Muster, G. (2003). Automated
whole mount localisation techniques for plant seedlings. Plant Journal.
Wiley. https://doi.org/10.1046/j.1365-313X.2003.01705.x
chicago: Friml, Jiří, Eva Benková, Ulrike Mayer, Klaus Palme, and Gerhard Muster.
“Automated Whole Mount Localisation Techniques for Plant Seedlings.” Plant
Journal. Wiley, 2003. https://doi.org/10.1046/j.1365-313X.2003.01705.x.
ieee: J. Friml, E. Benková, U. Mayer, K. Palme, and G. Muster, “Automated whole
mount localisation techniques for plant seedlings,” Plant Journal, vol.
34, no. 1. Wiley, pp. 115–124, 2003.
ista: Friml J, Benková E, Mayer U, Palme K, Muster G. 2003. Automated whole mount
localisation techniques for plant seedlings. Plant Journal. 34(1), 115–124.
mla: Friml, Jiří, et al. “Automated Whole Mount Localisation Techniques for Plant
Seedlings.” Plant Journal, vol. 34, no. 1, Wiley, 2003, pp. 115–24, doi:10.1046/j.1365-313X.2003.01705.x.
short: J. Friml, E. Benková, U. Mayer, K. Palme, G. Muster, Plant Journal 34 (2003)
115–124.
date_created: 2018-12-11T12:00:44Z
date_published: 2003-04-01T00:00:00Z
date_updated: 2026-05-22T09:01:28Z
day: '01'
doi: 10.1046/j.1365-313X.2003.01705.x
extern: '1'
external_id:
pmid:
- '12662314'
intvolume: ' 34'
issue: '1'
language:
- iso: eng
month: '04'
oa_version: None
page: 115 - 124
pmid: 1
publication: Plant Journal
publication_identifier:
eissn:
- 1365-313X
issn:
- 0960-7412
publication_status: published
publisher: Wiley
publist_id: '3709'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Automated whole mount localisation techniques for plant seedlings
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 34
year: '2003'
...
---
_id: '2995'
abstract:
- lang: eng
text: "Axis formation occurs in plants, as in animals, during early embryogenesis.
However, the underlying mechanism is not known. Here we show that the first manifestation
of the apical-basal axis in plants, the asymmetric division of the zygote, produces
a basal cell that transports and an apical cell that responds to the signalling
molecule auxin. This apical-basal auxin activity gradient triggers the specification
of apical embryo structures and is actively maintained by a novel component of
auxin efflux, PIN7, which is located apically in the basal cell. Later, the developmentally
regulated reversal of PIN7 and onset of PIN1 polar localization reorganize the
auxin gradient for specification of the basal root pole. An analysis of pin quadruple
mutants identifies PIN-dependent transport as an essential part of the mechanism
for embryo axis formation. Our results indicate how the establishment of cell
polarity, polar auxin efflux and local auxin response result in apical-basal axis
formation of the embryo, and thus determine the axiality of the adult plant.\r\n"
article_processing_charge: No
author:
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Anne
full_name: Vieten, Anne
last_name: Vieten
- first_name: Michael
full_name: Sauer, Michael
last_name: Sauer
- first_name: Dolf
full_name: Weijers, Dolf
last_name: Weijers
- first_name: Heinz
full_name: Schwarz, Heinz
last_name: Schwarz
- first_name: Thorsten
full_name: Hamann, Thorsten
last_name: Hamann
- first_name: Remko
full_name: Offringa, Remko
last_name: Offringa
- first_name: Gerd
full_name: Jürgens, Gerd
last_name: Jürgens
citation:
ama: Friml J, Vieten A, Sauer M, et al. Efflux dependent auxin gradients establish
the apical basal axis of Arabidopsis. Nature. 2003;426:147-153. doi:10.1038/nature02085
apa: Friml, J., Vieten, A., Sauer, M., Weijers, D., Schwarz, H., Hamann, T., … Jürgens,
G. (2003). Efflux dependent auxin gradients establish the apical basal axis of
Arabidopsis. Nature. Springer Nature. https://doi.org/10.1038/nature02085
chicago: Friml, Jiří, Anne Vieten, Michael Sauer, Dolf Weijers, Heinz Schwarz, Thorsten
Hamann, Remko Offringa, and Gerd Jürgens. “Efflux Dependent Auxin Gradients Establish
the Apical Basal Axis of Arabidopsis.” Nature. Springer Nature, 2003. https://doi.org/10.1038/nature02085.
ieee: J. Friml et al., “Efflux dependent auxin gradients establish the apical
basal axis of Arabidopsis,” Nature, vol. 426. Springer Nature, pp. 147–153,
2003.
ista: Friml J, Vieten A, Sauer M, Weijers D, Schwarz H, Hamann T, Offringa R, Jürgens
G. 2003. Efflux dependent auxin gradients establish the apical basal axis of Arabidopsis.
Nature. 426, 147–153.
mla: Friml, Jiří, et al. “Efflux Dependent Auxin Gradients Establish the Apical
Basal Axis of Arabidopsis.” Nature, vol. 426, Springer Nature, 2003, pp.
147–53, doi:10.1038/nature02085.
short: J. Friml, A. Vieten, M. Sauer, D. Weijers, H. Schwarz, T. Hamann, R. Offringa,
G. Jürgens, Nature 426 (2003) 147–153.
date_created: 2018-12-11T12:00:45Z
date_published: 2003-11-13T00:00:00Z
date_updated: 2026-05-22T08:58:10Z
day: '13'
doi: 10.1038/nature02085
extern: '1'
external_id:
pmid:
- '14614497 '
intvolume: ' 426'
language:
- iso: eng
month: '11'
oa_version: None
page: 147 - 153
pmid: 1
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
publist_id: '3708'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Efflux dependent auxin gradients establish the apical basal axis of Arabidopsis
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 426
year: '2003'
...
---
OA_type: closed access
_id: '3139'
article_processing_charge: No
author:
- first_name: Hsiao
full_name: Chen, Hsiao
last_name: Chen
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
- first_name: Silvia
full_name: Arber, Silvia
last_name: Arber
- first_name: Eric
full_name: Frank, Eric
last_name: Frank
citation:
ama: Chen H, Hippenmeyer S, Arber S, Frank E. Development of the monosynaptic stretch
reflex circuit. Current Opinion in Neurobiology. 2003;13(1):96-102. doi:10.1016/S0959-4388(03)00006-0
apa: Chen, H., Hippenmeyer, S., Arber, S., & Frank, E. (2003). Development of
the monosynaptic stretch reflex circuit. Current Opinion in Neurobiology.
Elsevier. https://doi.org/10.1016/S0959-4388(03)00006-0
chicago: Chen, Hsiao, Simon Hippenmeyer, Silvia Arber, and Eric Frank. “Development
of the Monosynaptic Stretch Reflex Circuit.” Current Opinion in Neurobiology.
Elsevier, 2003. https://doi.org/10.1016/S0959-4388(03)00006-0.
ieee: H. Chen, S. Hippenmeyer, S. Arber, and E. Frank, “Development of the monosynaptic
stretch reflex circuit,” Current Opinion in Neurobiology, vol. 13, no.
1. Elsevier, pp. 96–102, 2003.
ista: Chen H, Hippenmeyer S, Arber S, Frank E. 2003. Development of the monosynaptic
stretch reflex circuit. Current Opinion in Neurobiology. 13(1), 96–102.
mla: Chen, Hsiao, et al. “Development of the Monosynaptic Stretch Reflex Circuit.”
Current Opinion in Neurobiology, vol. 13, no. 1, Elsevier, 2003, pp. 96–102,
doi:10.1016/S0959-4388(03)00006-0.
short: H. Chen, S. Hippenmeyer, S. Arber, E. Frank, Current Opinion in Neurobiology
13 (2003) 96–102.
date_created: 2018-12-11T12:01:37Z
date_published: 2003-02-01T00:00:00Z
date_updated: 2026-05-22T08:40:52Z
day: '01'
doi: 10.1016/S0959-4388(03)00006-0
extern: '1'
external_id:
pmid:
- '12593987'
intvolume: ' 13'
issue: '1'
language:
- iso: eng
month: '02'
oa_version: None
page: 96 - 102
pmid: 1
publication: Current Opinion in Neurobiology
publication_identifier:
eissn:
- 1873-6882
issn:
- 0959-4388
publication_status: published
publisher: Elsevier
publist_id: '3557'
status: public
title: Development of the monosynaptic stretch reflex circuit
type: review
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 13
year: '2003'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '2633'
abstract:
- lang: eng
text: The modulation of calcium channels by metabotropic glutamate receptors (mGluRs)
is a key event in the fine-tuning of neurotransmitter release. Here we report
that, in cerebrocortical nerve terminals of adult rats, the inhibition of glutamate
release is mediated by mGluR7. In this preparation, the major component of glutamate
release is supported by P/Q-type Ca2+ channels (72.7%). However, mGluR7 selectively
reduced the release component that is associated with N-type Ca2+ channels (29.9%).
Inhibition of P/Q channels by mGluR7 is not masked by the higher efficiency of
these channels in driving glutamate release when compared with N-type channels.
Thus, activation of mGluR7 failed to reduce the release associated with P/Q channels
when the extracellular calcium concentration, ([Ca2+]o), was reduced from 1.3
to 0.5 mM. Through Ca2+ imaging, we show that Ca2+ channels are distributed in
a heterogeneous manner in individual nerve terminals. Indeed, in this preparation,
nerve terminals were observed that contain N-type (31.1%; conotoxin GVIA-sensitive)
or P/Q-type (64.3%; agatoxin IVA-sensitive) channels or that were insensitive
to these two toxins (4.6%). Interestingly, the great majority of the responses
to L-AP4 (95.4%) were observed in nerve terminals containing N-type channels.
This specific co-localization of mGluR7 and N-type Ca2+-channels could explain
the failure of the receptor to inhibit the P/Q channel-associated release component
and also reveal the existence of specific targeting mechanisms to localize the
two proteins in the same nerve terminal subset.
article_processing_charge: No
article_type: original
author:
- first_name: Carmelo
full_name: Millán, Carmelo
last_name: Millán
- first_name: Enrique
full_name: Castro, Enrique
last_name: Castro
- first_name: Magdalena
full_name: Torres, Magdalena
last_name: Torres
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: José
full_name: Sánchez Prieto, José
last_name: Sánchez Prieto
citation:
ama: Millán C, Castro E, Torres M, Shigemoto R, Sánchez Prieto J. Co-expression
of metabotropic glutamate receptor 7 and N-type Ca2+ channels in single cerebrocortical
nerve terminals of adult rats. Journal of Biological Chemistry. 2003;278(26):23955-23962.
doi:10.1074/jbc.M211471200
apa: Millán, C., Castro, E., Torres, M., Shigemoto, R., & Sánchez Prieto, J.
(2003). Co-expression of metabotropic glutamate receptor 7 and N-type Ca2+ channels
in single cerebrocortical nerve terminals of adult rats. Journal of Biological
Chemistry. Elsevier. https://doi.org/10.1074/jbc.M211471200
chicago: Millán, Carmelo, Enrique Castro, Magdalena Torres, Ryuichi Shigemoto, and
José Sánchez Prieto. “Co-Expression of Metabotropic Glutamate Receptor 7 and N-Type
Ca2+ Channels in Single Cerebrocortical Nerve Terminals of Adult Rats.” Journal
of Biological Chemistry. Elsevier, 2003. https://doi.org/10.1074/jbc.M211471200.
ieee: C. Millán, E. Castro, M. Torres, R. Shigemoto, and J. Sánchez Prieto, “Co-expression
of metabotropic glutamate receptor 7 and N-type Ca2+ channels in single cerebrocortical
nerve terminals of adult rats,” Journal of Biological Chemistry, vol. 278,
no. 26. Elsevier, pp. 23955–23962, 2003.
ista: Millán C, Castro E, Torres M, Shigemoto R, Sánchez Prieto J. 2003. Co-expression
of metabotropic glutamate receptor 7 and N-type Ca2+ channels in single cerebrocortical
nerve terminals of adult rats. Journal of Biological Chemistry. 278(26), 23955–23962.
mla: Millán, Carmelo, et al. “Co-Expression of Metabotropic Glutamate Receptor 7
and N-Type Ca2+ Channels in Single Cerebrocortical Nerve Terminals of Adult Rats.”
Journal of Biological Chemistry, vol. 278, no. 26, Elsevier, 2003, pp.
23955–62, doi:10.1074/jbc.M211471200.
short: C. Millán, E. Castro, M. Torres, R. Shigemoto, J. Sánchez Prieto, Journal
of Biological Chemistry 278 (2003) 23955–23962.
date_created: 2018-12-11T11:58:47Z
date_published: 2003-07-27T00:00:00Z
date_updated: 2026-05-22T10:29:51Z
day: '27'
doi: 10.1074/jbc.M211471200
extern: '1'
external_id:
pmid:
- '12692128 '
intvolume: ' 278'
issue: '26'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
main_file_link:
- open_access: '1'
url: https://doi.org/10.1074/jbc.M211471200
month: '07'
oa: 1
oa_version: Published Version
page: 23955 - 23962
pmid: 1
publication: Journal of Biological Chemistry
publication_identifier:
eissn:
- 1083-351X
issn:
- 0021-9258
publication_status: published
publisher: Elsevier
publist_id: '4265'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Co-expression of metabotropic glutamate receptor 7 and N-type Ca2+ channels
in single cerebrocortical nerve terminals of adult rats
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 278
year: '2003'
...
---
OA_type: closed access
_id: '2635'
abstract:
- lang: eng
text: Metabotropic GABAB receptors mediate slow inhibitory effects presynaptically
and postsynaptically. Using preembedding immunohistochemical methods combined
with quantitative analysis of GABAB receptor subunit immunoreactivity, this study
provides a detailed description of the cellular and subcellular localization of
GABAB1a/b and GABA B2 in the rat hippocampus. At the light microscopic level,
an overlapping distribution of GABAB1a/b and GABAB2 was revealed in the dendritic
layers of the hippocampus. In addition, expression of the GABAB1a/b subunit was
found in somata of CA1 pyramidal cells and of a subset of GABAergic interneurons.
At the electron microscopic level, immunoreactivity for both subunits was observed
on presynaptic and, more abundantly, on postsynaptic elements. Presynaptically,
subunits were mainly detected in the extrasynaptic membrane and occasionally over
the presynaptic membrane specialization of putative glutamatergic and, to a lesser
extent, GABAergic axon terminals. Postsynaptically, the majority of GABAB receptor
subunits were localized to the extrasynaptic plasma membrane of spines and dendritic
shafts of principal cells and shafts of interneuron dendrites. Quantitative analysis
revealed enrichment of GABAB1a/b around putative glutamatergic synapses on spines
and an even distribution on dendritic shafts of pyramidal cells contacted by GABAergic
boutons. The association of GABAB receptors with glutamatergic synapses at both
presynaptic and postsynaptic sides indicates their intimate involvement in the
modulation of glutamatergic neurotransmission. The dominant extrasynaptic localization
of GABAB receptor subunits suggests that their activation is dependent on spillover
of GABA requiring simultaneous activity of populations of GABAergic cells as it
occurs during population oscillations or epileptic seizures.
article_processing_charge: No
article_type: original
author:
- first_name: Ákos
full_name: Kulik, Ákos
last_name: Kulik
- first_name: Imre
full_name: Vida, Imre
last_name: Vida
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
- first_name: Carola
full_name: Haas, Carola
last_name: Haas
- first_name: Guillermina
full_name: López Bendito, Guillermina
last_name: López Bendito
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Michael
full_name: Frotscher, Michael
last_name: Frotscher
citation:
ama: Kulik Á, Vida I, Luján R, et al. Subcellular Localization of Metabotropic GABAB
Receptor Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus. Journal of Neuroscience.
2003;23(35):11026-11035. doi:10.1523/JNEUROSCI.23-35-11026.2003
apa: Kulik, Á., Vida, I., Luján, R., Haas, C., López Bendito, G., Shigemoto, R.,
& Frotscher, M. (2003). Subcellular Localization of Metabotropic GABAB Receptor
Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus. Journal of Neuroscience.
Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.23-35-11026.2003
chicago: Kulik, Ákos, Imre Vida, Rafael Luján, Carola Haas, Guillermina López Bendito,
Ryuichi Shigemoto, and Michael Frotscher. “Subcellular Localization of Metabotropic
GABAB Receptor Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus.” Journal
of Neuroscience. Society for Neuroscience, 2003. https://doi.org/10.1523/JNEUROSCI.23-35-11026.2003.
ieee: Á. Kulik et al., “Subcellular Localization of Metabotropic GABAB Receptor
Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus,” Journal of Neuroscience,
vol. 23, no. 35. Society for Neuroscience, pp. 11026–11035, 2003.
ista: Kulik Á, Vida I, Luján R, Haas C, López Bendito G, Shigemoto R, Frotscher
M. 2003. Subcellular Localization of Metabotropic GABAB Receptor Subunits GABAB1a/b
and GABAB2 in the Rat Hippocampus. Journal of Neuroscience. 23(35), 11026–11035.
mla: Kulik, Ákos, et al. “Subcellular Localization of Metabotropic GABAB Receptor
Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus.” Journal of Neuroscience,
vol. 23, no. 35, Society for Neuroscience, 2003, pp. 11026–35, doi:10.1523/JNEUROSCI.23-35-11026.2003.
short: Á. Kulik, I. Vida, R. Luján, C. Haas, G. López Bendito, R. Shigemoto, M.
Frotscher, Journal of Neuroscience 23 (2003) 11026–11035.
date_created: 2018-12-11T11:58:47Z
date_published: 2003-12-03T00:00:00Z
date_updated: 2026-05-22T09:50:16Z
day: '03'
doi: 10.1523/JNEUROSCI.23-35-11026.2003
extern: '1'
external_id:
pmid:
- '14657159'
intvolume: ' 23'
issue: '35'
language:
- iso: eng
month: '12'
oa_version: None
page: 11026 - 11035
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
eissn:
- 1529-2401
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4263'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Subcellular Localization of Metabotropic GABAB Receptor Subunits GABAB1a/b
and GABAB2 in the Rat Hippocampus
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 23
year: '2003'
...
---
OA_type: closed access
_id: '2632'
abstract:
- lang: eng
text: In many brain regions, hyperpolarization-activated cationic currents (Ih)
are involved in the generation of rhythmic activities, but the role of Ih in olfactory
oscillations remains unclear. Knowledge of the cellular and subcellular distributions
of hyperpolarization-activated and cyclic nucleotide-gated channel (HCN) subunits
is necessary for understanding the role of Ih in olfactory network activities.
Using light microscopic immunocytochemistry, we demonstrate strong HCN1 labelling
of the glomerular layer and moderate staining of granule cell, internal and external
plexiform layers of the rat main olfactory bulb. In the glomerular layer, among
many unlabelled neurons, two distinct subpopulations of juxtaglomerular cells
are labelled. Approximately 10% of the juxtaglomerular cells strongly express
HCN1. These small diameter cells are immunoreactive for GABA and comprise a subpopulation
of periglomerular cells. An additional subset of juxtaglomerular cells (≈ 1%)
expresses low levels of HCN1. They are large in diameter, GABA immunonegative
but immunopositive for vesicular glutamate transporter 2, characterizing them
as external tufted cells. Quantitative immunogold localization revealed that the
somatic plasma membranes of periglomerular cells contain approximately four times
more HCN1 labelling than those of external tufted cells. Unlike in cortical pyramidal
cells, immunogold density for HCN1 does not significantly differ in somatic and
dendritic plasma membranes of external tufted cells, indicating that post-synaptic
potentials arriving at proximal and distal dendrites are modulated by the same
density of I h. Our results demonstrate a cell type-dependent expression of HCN1
in the olfactory bulb and predict a differential contribution of distinct juxtaglomerular
cell types to network oscillations.
article_processing_charge: No
article_type: original
author:
- first_name: Noémi
full_name: Holderith, Noémi
last_name: Holderith
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Zoltán
full_name: Nusser, Zoltán
last_name: Nusser
citation:
ama: Holderith N, Shigemoto R, Nusser Z. Cell type-dependent expression of HCN1
in the main olfactory bulb. European Journal of Neuroscience. 2003;18(2):344-354.
doi:10.1046/j.1460-9568.2003.02756.x
apa: Holderith, N., Shigemoto, R., & Nusser, Z. (2003). Cell type-dependent
expression of HCN1 in the main olfactory bulb. European Journal of Neuroscience.
Wiley-Blackwell. https://doi.org/10.1046/j.1460-9568.2003.02756.x
chicago: Holderith, Noémi, Ryuichi Shigemoto, and Zoltán Nusser. “Cell Type-Dependent
Expression of HCN1 in the Main Olfactory Bulb.” European Journal of Neuroscience.
Wiley-Blackwell, 2003. https://doi.org/10.1046/j.1460-9568.2003.02756.x.
ieee: N. Holderith, R. Shigemoto, and Z. Nusser, “Cell type-dependent expression
of HCN1 in the main olfactory bulb,” European Journal of Neuroscience,
vol. 18, no. 2. Wiley-Blackwell, pp. 344–354, 2003.
ista: Holderith N, Shigemoto R, Nusser Z. 2003. Cell type-dependent expression of
HCN1 in the main olfactory bulb. European Journal of Neuroscience. 18(2), 344–354.
mla: Holderith, Noémi, et al. “Cell Type-Dependent Expression of HCN1 in the Main
Olfactory Bulb.” European Journal of Neuroscience, vol. 18, no. 2, Wiley-Blackwell,
2003, pp. 344–54, doi:10.1046/j.1460-9568.2003.02756.x.
short: N. Holderith, R. Shigemoto, Z. Nusser, European Journal of Neuroscience 18
(2003) 344–354.
date_created: 2018-12-11T11:58:47Z
date_published: 2003-07-01T00:00:00Z
date_updated: 2026-05-22T10:45:14Z
day: '01'
doi: 10.1046/j.1460-9568.2003.02756.x
extern: '1'
external_id:
pmid:
- '12887416'
intvolume: ' 18'
issue: '2'
language:
- iso: eng
month: '07'
oa_version: None
page: 344 - 354
pmid: 1
publication: European Journal of Neuroscience
publication_identifier:
eissn:
- 1460-9568
issn:
- 0953-816X
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4266'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cell type-dependent expression of HCN1 in the main olfactory bulb
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 18
year: '2003'
...