---
OA_place: repository
OA_type: free access
_id: '17803'
abstract:
- lang: eng
text: We reassess constraints on the cosmological baryon density from observations
of the mean decrement and power spectrum of the Lyα forest, taking into account
uncertainties in all free parameters in the simplest gravitational instability
model. The uncertainty is dominated by that of the photoionizing background, but
incomplete knowledge of the thermal state of the intergalactic medium also contributes
significantly to the error budget. While current estimates of the baryon fraction
from the forest do prefer values that are somewhat higher than the big bang nucleosynthesis
value of Ωb h2 = 0.02 ± 0.001, the discrepancy is at most about 3 σ. For instance,
assuming the highest estimate of the ionizing background, as indicated by recent
measurements of a large escape fraction from Lyman break galaxies by Steidel,
Pettini, & Adelberger, we find Ωbh2 = 0.045 ± 0.008. A recent measurement of the
ionizing background from the proximity effect by Scott et al., on the other hand,
implies Ωbh2 = 0.03 ± 0.01. We provide an expression from which future likelihoods
for Ωb h2 can be derived as measurements of the ionizing background improve—consistency
among constraints from the forest, nucleosynthesis, and the microwave background
will provide a powerful test of the gravitational instability model for the forest
and for large-scale structure in general. We also develop a formalism that treats
lower bounds on the baryon density in a statistical manner, which is appropriate
if only a lower bound on the ionizing background is known. Finally, we discuss
the implications of the escape fraction measurement for the age, structure, and
stellar content of Lyman break galaxies. We show that the observed hard spectrum
from Lyman break galaxies requires a very young age (less than about 1 million
years) and/or a top-heavy initial mass function. We also build a model in which
an extended (non-disk-like) gas distribution allows a large escape fraction.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Lam
full_name: Hui, Lam
last_name: Hui
- first_name: Zoltán
full_name: Haiman, Zoltán
id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
last_name: Haiman
orcid: 0000-0003-3633-5403
- first_name: Matias
full_name: Zaldarriaga, Matias
last_name: Zaldarriaga
- first_name: Tal
full_name: Alexander, Tal
last_name: Alexander
citation:
ama: Hui L, Haiman Z, Zaldarriaga M, Alexander T. Connections between the cosmic
baryon fraction, the extragalactic ionizing background, and Lyman break galaxies.
The Astrophysical Journal. 2002;564(2):525-533. doi:10.1086/324401
apa: Hui, L., Haiman, Z., Zaldarriaga, M., & Alexander, T. (2002). Connections
between the cosmic baryon fraction, the extragalactic ionizing background, and
Lyman break galaxies. The Astrophysical Journal. American Astronomical
Society. https://doi.org/10.1086/324401
chicago: Hui, Lam, Zoltán Haiman, Matias Zaldarriaga, and Tal Alexander. “Connections
between the Cosmic Baryon Fraction, the Extragalactic Ionizing Background, and
Lyman Break Galaxies.” The Astrophysical Journal. American Astronomical
Society, 2002. https://doi.org/10.1086/324401.
ieee: L. Hui, Z. Haiman, M. Zaldarriaga, and T. Alexander, “Connections between
the cosmic baryon fraction, the extragalactic ionizing background, and Lyman break
galaxies,” The Astrophysical Journal, vol. 564, no. 2. American Astronomical
Society, pp. 525–533, 2002.
ista: Hui L, Haiman Z, Zaldarriaga M, Alexander T. 2002. Connections between the
cosmic baryon fraction, the extragalactic ionizing background, and Lyman break
galaxies. The Astrophysical Journal. 564(2), 525–533.
mla: Hui, Lam, et al. “Connections between the Cosmic Baryon Fraction, the Extragalactic
Ionizing Background, and Lyman Break Galaxies.” The Astrophysical Journal,
vol. 564, no. 2, American Astronomical Society, 2002, pp. 525–33, doi:10.1086/324401.
short: L. Hui, Z. Haiman, M. Zaldarriaga, T. Alexander, The Astrophysical Journal
564 (2002) 525–533.
date_created: 2024-09-06T11:31:53Z
date_published: 2002-01-10T00:00:00Z
date_updated: 2024-11-12T10:08:42Z
day: '10'
doi: 10.1086/324401
extern: '1'
external_id:
arxiv:
- astro-ph/0104442
intvolume: ' 564'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.astro-ph/0104442
month: '01'
oa: 1
oa_version: Preprint
page: 525-533
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: American Astronomical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Connections between the cosmic baryon fraction, the extragalactic ionizing
background, and Lyman break galaxies
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 564
year: '2002'
...
---
_id: '859'
abstract:
- lang: eng
text: The polymeric ubiquitin (poly-u) genes are composed of tandem 228-bp repeats
with no spacer sequences between individual monomer units. Ubiquitin is one of
the most conserved proteins known to date, and the individual units within a number
of poly-u genes are significantly more similar to each other than would be expected
if each unit evolved independently. It has been proposed that the rather striking
similarity among poly-u monomers in some lineages is caused by a series of homogenization
events. Here we report the sequences of the polyubiquitin-C (Ubc) genes in two
mouse strains. Analysis of these sequences, as well as those of the previously
reported Chinese hamster and rat poly-u genes, supports the assertion that the
homogenization of the ubiquitin-C gene in rodents is due to unequal crossing-over
events. The sequence divergence of noncoding DNA was used to estimate the frequency
of unequal crossing-over events (6.3 x 10-5 events per generation) in the Ubc
gene, as well as to provide evidence of apparent selection in the poly-u gene.
acknowledgement: We are thankful to J.A. Southerland and P.L. Jiang for technical
assistance in DNA sequencing, as well as to Y.I. Pavlov for helpful discussions.
This work was supported by public Health Service Research Grant AI45135 from the
Institute of Allergy and Infectious Diseases, National Institutes of Health.
article_processing_charge: No
article_type: original
author:
- first_name: Andrey
full_name: Perelygin, Andrey
last_name: Perelygin
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Igor
full_name: Rogozin, Igor
last_name: Rogozin
- first_name: Margo
full_name: Brinton, Margo
last_name: Brinton
citation:
ama: Perelygin A, Kondrashov F, Rogozin I, Brinton M. Evolution of the mouse polyubiquitin
C gene. Journal of Molecular Evolution. 2002;55(2):202-210. doi:10.1007/s00239-002-2318-0
apa: Perelygin, A., Kondrashov, F., Rogozin, I., & Brinton, M. (2002). Evolution
of the mouse polyubiquitin C gene. Journal of Molecular Evolution. Springer.
https://doi.org/10.1007/s00239-002-2318-0
chicago: Perelygin, Andrey, Fyodor Kondrashov, Igor Rogozin, and Margo Brinton.
“Evolution of the Mouse Polyubiquitin C Gene.” Journal of Molecular Evolution.
Springer, 2002. https://doi.org/10.1007/s00239-002-2318-0.
ieee: A. Perelygin, F. Kondrashov, I. Rogozin, and M. Brinton, “Evolution of the
mouse polyubiquitin C gene,” Journal of Molecular Evolution, vol. 55, no.
2. Springer, pp. 202–210, 2002.
ista: Perelygin A, Kondrashov F, Rogozin I, Brinton M. 2002. Evolution of the mouse
polyubiquitin C gene. Journal of Molecular Evolution. 55(2), 202–210.
mla: Perelygin, Andrey, et al. “Evolution of the Mouse Polyubiquitin C Gene.” Journal
of Molecular Evolution, vol. 55, no. 2, Springer, 2002, pp. 202–10, doi:10.1007/s00239-002-2318-0.
short: A. Perelygin, F. Kondrashov, I. Rogozin, M. Brinton, Journal of Molecular
Evolution 55 (2002) 202–210.
date_created: 2018-12-11T11:48:53Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-07-26T12:01:34Z
day: '01'
doi: 10.1007/s00239-002-2318-0
extern: '1'
external_id:
pmid:
- '12107596'
intvolume: ' 55'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 202 - 210
pmid: 1
publication: Journal of Molecular Evolution
publication_identifier:
issn:
- 0022-2844
publication_status: published
publisher: Springer
publist_id: '6787'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Evolution of the mouse polyubiquitin C gene
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 55
year: '2002'
...
---
_id: '871'
abstract:
- lang: eng
text: 'BACKGROUND: Gene duplications have a major role in the evolution of new biological
functions. Theoretical studies often assume that a duplication per se is selectively
neutral and that, following a duplication, one of the gene copies is freed from
purifying (stabilizing) selection, which creates the potential for evolution of
a new function. RESULTS: In search of systematic evidence of accelerated evolution
after duplication, we used data from 26 bacterial, six archaeal, and seven eukaryotic
genomes to compare the mode and strength of selection acting on recently duplicated
genes (paralogs) and on similarly diverged, unduplicated orthologous genes in
different species. We find that the ratio of nonsynonymous to synonymous substitutions
(Kn/Ks) in most paralogous pairs is <<1 and that paralogs typically evolve
at similar rates, without significant asymmetry, indicating that both paralogs
produced by a duplication are subject to purifying selection. This selection is,
however, substantially weaker than the purifying selection affecting unduplicated
orthologs that have diverged to the same extent as the analyzed paralogs. Most
of the recently duplicated genes appear to be involved in various forms of environmental
response; in particular, many of them encode membrane and secreted proteins. CONCLUSIONS:
The results of this analysis indicate that recently duplicated paralogs evolve
faster than orthologs with the same level of divergence and similar functions,
but apparently do not experience a phase of neutral evolution. We hypothesize
that gene duplications that persist in an evolving lineage are beneficial from
the time of their origin, due primarily to a protein dosage effect in response
to variable environmental conditions; duplications are likely to give rise to
new functions at a later phase of their evolution once a higher level of divergence
is reached.'
acknowledgement: We are grateful to A.S. Kondrashov for numerous helpful suggestions,
to I. King Jordan, M.A. Roytberg, J.L. Spouge and D.A. Kondrashov for useful discussions
and to A.S. Kondrashov, I. King Jordan and D.J. Lipman for critical reading of the
manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Igor
full_name: Rogozin, Igor
last_name: Rogozin
- first_name: Yuri
full_name: Wolf, Yuri
last_name: Wolf
- first_name: Eugene
full_name: Koonin, Eugene
last_name: Koonin
citation:
ama: Kondrashov F, Rogozin I, Wolf Y, Koonin E. Selection in the evolution of gene
duplications . Genome Biology. 2002;3(2). doi:10.1186/gb-2002-3-2-research0008
apa: Kondrashov, F., Rogozin, I., Wolf, Y., & Koonin, E. (2002). Selection in
the evolution of gene duplications . Genome Biology. BioMed Central. https://doi.org/10.1186/gb-2002-3-2-research0008
chicago: Kondrashov, Fyodor, Igor Rogozin, Yuri Wolf, and Eugene Koonin. “Selection
in the Evolution of Gene Duplications .” Genome Biology. BioMed Central,
2002. https://doi.org/10.1186/gb-2002-3-2-research0008.
ieee: F. Kondrashov, I. Rogozin, Y. Wolf, and E. Koonin, “Selection in the evolution
of gene duplications ,” Genome Biology, vol. 3, no. 2. BioMed Central,
2002.
ista: Kondrashov F, Rogozin I, Wolf Y, Koonin E. 2002. Selection in the evolution
of gene duplications . Genome Biology. 3(2).
mla: Kondrashov, Fyodor, et al. “Selection in the Evolution of Gene Duplications
.” Genome Biology, vol. 3, no. 2, BioMed Central, 2002, doi:10.1186/gb-2002-3-2-research0008.
short: F. Kondrashov, I. Rogozin, Y. Wolf, E. Koonin, Genome Biology 3 (2002).
date_created: 2018-12-11T11:48:57Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-07-26T11:48:27Z
day: '01'
doi: 10.1186/gb-2002-3-2-research0008
extern: '1'
external_id:
pmid:
- '11864370'
intvolume: ' 3'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC65685/
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
publication: Genome Biology
publication_identifier:
issn:
- 1465-6906
publication_status: published
publisher: BioMed Central
publist_id: '6781'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Selection in the evolution of gene duplications '
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 3
year: '2002'
...
---
_id: '885'
abstract:
- lang: eng
text: We study fitness landscape in the space of protein sequences by relating sets
of human pathogenic missense mutations in 32 proteins to amino acid substitutions
that occurred in the course of evolution of these proteins. On average, ≈10% of
deviations of a nonhuman protein from its human ortholog are compensated pathogenic
deviations (CPDs), i.e., are caused by an amino acid substitution that, at this
site, would be pathogenic to humans. Normal functioning of a CPD-containing protein
must be caused by other, compensatory deviations of the nonhuman species from
humans. Together, a CPD and the corresponding compensatory deviation form a Dobzhansky-Muller
incompatibility that can be visualized as the corner on a fitness ridge. Thus,
proteins evolve along fitness ridges which contain only ≈10 steps between sucessive
corners. The fraction of CPDs among all deviations of a protein from its human
ortholog does not increase with the evolutionary distance between the proteins,
indicating that subtitutions that carry evolving proteins around these corners
occur in rapid succession, driven by positive selection. Data on fitness of interspecies
hybrids suggest that the compensatory change that makes a CPD fit usually occurs
within the same protein. Data on protein structures and on cooccurrence of amino
acids at different sites of multiple orthologous proteins often make it possible
to provisionally identify the substitution that compensates a partiCUlar CPD.
article_processing_charge: No
article_type: original
author:
- first_name: Alexey
full_name: Kondrashov, Alexey
last_name: Kondrashov
- first_name: Shamil
full_name: Sunyaev, Shamil
last_name: Sunyaev
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
citation:
ama: Kondrashov A, Sunyaev S, Kondrashov F. Dobzhansky-Muller incompatibilities
in protein evolution. PNAS. 2002;99(23):14878-14883. doi:10.1073/pnas.232565499
apa: Kondrashov, A., Sunyaev, S., & Kondrashov, F. (2002). Dobzhansky-Muller
incompatibilities in protein evolution. PNAS. National Academy of Sciences.
https://doi.org/10.1073/pnas.232565499
chicago: Kondrashov, Alexey, Shamil Sunyaev, and Fyodor Kondrashov. “Dobzhansky-Muller
Incompatibilities in Protein Evolution.” PNAS. National Academy of Sciences,
2002. https://doi.org/10.1073/pnas.232565499.
ieee: A. Kondrashov, S. Sunyaev, and F. Kondrashov, “Dobzhansky-Muller incompatibilities
in protein evolution,” PNAS, vol. 99, no. 23. National Academy of Sciences,
pp. 14878–14883, 2002.
ista: Kondrashov A, Sunyaev S, Kondrashov F. 2002. Dobzhansky-Muller incompatibilities
in protein evolution. PNAS. 99(23), 14878–14883.
mla: Kondrashov, Alexey, et al. “Dobzhansky-Muller Incompatibilities in Protein
Evolution.” PNAS, vol. 99, no. 23, National Academy of Sciences, 2002,
pp. 14878–83, doi:10.1073/pnas.232565499.
short: A. Kondrashov, S. Sunyaev, F. Kondrashov, PNAS 99 (2002) 14878–14883.
date_created: 2018-12-11T11:49:01Z
date_published: 2002-11-12T00:00:00Z
date_updated: 2023-07-26T09:48:37Z
day: '12'
doi: 10.1073/pnas.232565499
extern: '1'
external_id:
pmid:
- '12403824'
intvolume: ' 99'
issue: '23'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137512/
month: '11'
oa: 1
oa_version: Published Version
page: 14878 - 14883
pmid: 1
publication: PNAS
publication_identifier:
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
publist_id: '6763'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dobzhansky-Muller incompatibilities in protein evolution
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 99
year: '2002'
...
---
_id: '897'
abstract:
- lang: eng
text: "Transcription is a slow and expensive process: in eukaryotes, approximately
20 nucleotides can be transcribed per second at the expense of at least two ATP
molecules per nucleotide. Thus, at least for highly expressed genes, transcription
of long introns, which are particularly common in mammals, is costly. Using data
on the expression of genes that encode proteins in Caenorhabditis elegans and
Homo sapiens, we show that introns in highly expressed genes are substantially
shorter than those in genes that are expressed at low levels. This difference
is greater in humans, such that introns are, on average, 14 times shorter in highly
expressed genes than in genes with low expression, whereas in C. Elegans the difference
in intron length is only twofold. In contrast, the density of introns in a gene
does not strongly depend on the level of gene expression. Thus, natural selection
appears to favor short introns in highly expressed genes to minimize the cost
of transcription and other molecular processes, such as splicing.\r\n"
acknowledgement: We are grateful to A. Kondrashov, I. Rogozin and A. Feldman for reading
the manuscript and P. Bouman, J. Cherry, J. Blumensteil and T. Kim for discussion.
article_processing_charge: No
article_type: original
author:
- first_name: Cristian
full_name: Castillo Davis, Cristian
last_name: Castillo Davis
- first_name: Sergei
full_name: Mekhedov, Sergei
last_name: Mekhedov
- first_name: Daniel
full_name: Hartl, Daniel
last_name: Hartl
- first_name: Eugene
full_name: Koonin, Eugene
last_name: Koonin
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
citation:
ama: Castillo Davis C, Mekhedov S, Hartl D, Koonin E, Kondrashov F. Selection for
short introns in highly expressed genes. Nature Genetics. 2002;31(4):415-418.
doi:10.1038/ng940
apa: Castillo Davis, C., Mekhedov, S., Hartl, D., Koonin, E., & Kondrashov,
F. (2002). Selection for short introns in highly expressed genes. Nature Genetics.
Nature Publishing Group. https://doi.org/10.1038/ng940
chicago: Castillo Davis, Cristian, Sergei Mekhedov, Daniel Hartl, Eugene Koonin,
and Fyodor Kondrashov. “Selection for Short Introns in Highly Expressed Genes.”
Nature Genetics. Nature Publishing Group, 2002. https://doi.org/10.1038/ng940.
ieee: C. Castillo Davis, S. Mekhedov, D. Hartl, E. Koonin, and F. Kondrashov, “Selection
for short introns in highly expressed genes,” Nature Genetics, vol. 31,
no. 4. Nature Publishing Group, pp. 415–418, 2002.
ista: Castillo Davis C, Mekhedov S, Hartl D, Koonin E, Kondrashov F. 2002. Selection
for short introns in highly expressed genes. Nature Genetics. 31(4), 415–418.
mla: Castillo Davis, Cristian, et al. “Selection for Short Introns in Highly Expressed
Genes.” Nature Genetics, vol. 31, no. 4, Nature Publishing Group, 2002,
pp. 415–18, doi:10.1038/ng940.
short: C. Castillo Davis, S. Mekhedov, D. Hartl, E. Koonin, F. Kondrashov, Nature
Genetics 31 (2002) 415–418.
date_created: 2018-12-11T11:49:05Z
date_published: 2002-08-01T00:00:00Z
date_updated: 2023-07-26T09:45:30Z
day: '01'
doi: 10.1038/ng940
extern: '1'
external_id:
pmid:
- '12134150'
intvolume: ' 31'
issue: '4'
language:
- iso: eng
month: '08'
oa_version: None
page: 415 - 418
pmid: 1
publication: Nature Genetics
publication_status: published
publisher: Nature Publishing Group
publist_id: '6751'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Selection for short introns in highly expressed genes
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 31
year: '2002'
...
---
_id: '4631'
abstract:
- lang: eng
text: We present a theory of timed interfaces, which is capable of specifying both
the timing of the inputs a component expects from the environment, and the timing
of the outputs it can produce. Two timed interfaces are compatible if there is
a way to use them together such that their timing expectations are met. Our theory
provides algorithms for checking the compatibility between two interfaces and
for deriving the composite interface; the theory can thus be viewed as a type
system for real-time interaction. Technically, a timed interface is encoded as
a timed game between two players, representing the inputs and outputs of the component.
The algorithms for compatibility checking and interface composition are thus derived
from algorithms for solving timed games.
acknowledgement: This research was supported in part by the NSF CAREER award CCR-0132780,
the NSF grant CCR-9988172 the AFOSR MURI grant F49620-00-1-0327, the DARPA PCES
grant F33615-00-C-1693, the MARCO GSRC grant 98-DT-660, and the ONR grant N00014-02-1-0671.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Luca
full_name: De Alfaro, Luca
last_name: De Alfaro
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Mariëlle
full_name: Stoelinga, Mariëlle
last_name: Stoelinga
citation:
ama: 'De Alfaro L, Henzinger TA, Stoelinga M. Timed interfaces. In: Proceedings
of the 2nd International Conference on Embedded Software. Vol 2491. ACM; 2002:108-122.
doi:10.1007/3-540-45828-X_9'
apa: 'De Alfaro, L., Henzinger, T. A., & Stoelinga, M. (2002). Timed interfaces.
In Proceedings of the 2nd International Conference on Embedded Software
(Vol. 2491, pp. 108–122). Grenoble, France: ACM. https://doi.org/10.1007/3-540-45828-X_9'
chicago: De Alfaro, Luca, Thomas A Henzinger, and Mariëlle Stoelinga. “Timed Interfaces.”
In Proceedings of the 2nd International Conference on Embedded Software,
2491:108–22. ACM, 2002. https://doi.org/10.1007/3-540-45828-X_9.
ieee: L. De Alfaro, T. A. Henzinger, and M. Stoelinga, “Timed interfaces,” in Proceedings
of the 2nd International Conference on Embedded Software, Grenoble, France,
2002, vol. 2491, pp. 108–122.
ista: 'De Alfaro L, Henzinger TA, Stoelinga M. 2002. Timed interfaces. Proceedings
of the 2nd International Conference on Embedded Software. EMSOFT: Embedded Software
, LNCS, vol. 2491, 108–122.'
mla: De Alfaro, Luca, et al. “Timed Interfaces.” Proceedings of the 2nd International
Conference on Embedded Software, vol. 2491, ACM, 2002, pp. 108–22, doi:10.1007/3-540-45828-X_9.
short: L. De Alfaro, T.A. Henzinger, M. Stoelinga, in:, Proceedings of the 2nd International
Conference on Embedded Software, ACM, 2002, pp. 108–122.
conference:
end_date: 2002-10-09
location: Grenoble, France
name: 'EMSOFT: Embedded Software '
start_date: 2002-10-07
date_created: 2018-12-11T12:09:51Z
date_published: 2002-10-24T00:00:00Z
date_updated: 2023-06-02T10:00:32Z
day: '24'
doi: 10.1007/3-540-45828-X_9
extern: '1'
intvolume: ' 2491'
language:
- iso: eng
month: '10'
oa_version: None
page: 108 - 122
publication: Proceedings of the 2nd International Conference on Embedded Software
publication_identifier:
isbn:
- '9783540443070'
publication_status: published
publisher: ACM
publist_id: '76'
quality_controlled: '1'
status: public
title: Timed interfaces
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 2491
year: '2002'
...
---
_id: '6158'
abstract:
- lang: eng
text: Wild isolates of Caenorhabditis elegans can feed either alone or in groups1,2.
This natural variation in behaviour is associated with a single residue difference
in NPR-1, a predicted G-protein-coupled neuropeptide receptor related to Neuropeptide
Y receptors2. Here we show that the NPR-1 isoform associated with solitary feeding
acts in neurons exposed to the body fluid to inhibit social feeding. Furthermore,
suppressing the activity of these neurons, called AQR, PQR and URX, using an activated
K+ channel, inhibits social feeding. NPR-1 activity in AQR, PQR and URX neurons
seems to suppress social feeding by antagonizing signalling through a cyclic GMP-gated
ion channel encoded by tax-2 and tax-4. We show that mutations in tax-2 or tax-4
disrupt social feeding, and that tax-4 is required in several neurons for social
feeding, including one or more of AQR, PQR and URX. The AQR, PQR and URX neurons
are unusual in C. elegans because they are directly exposed to the pseudocoelomic
body fluid3. Our data suggest a model in which these neurons integrate antagonistic
signals to control the choice between social and solitary feeding behaviour.
author:
- first_name: Juliet C.
full_name: Coates, Juliet C.
last_name: Coates
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
citation:
ama: Coates JC, de Bono M. Antagonistic pathways in neurons exposed to body fluid
regulate social feeding in Caenorhabditis elegans. Nature. 2002;419(6910):925-929.
doi:10.1038/nature01170
apa: Coates, J. C., & de Bono, M. (2002). Antagonistic pathways in neurons exposed
to body fluid regulate social feeding in Caenorhabditis elegans. Nature.
Springer Nature. https://doi.org/10.1038/nature01170
chicago: Coates, Juliet C., and Mario de Bono. “Antagonistic Pathways in Neurons
Exposed to Body Fluid Regulate Social Feeding in Caenorhabditis Elegans.” Nature.
Springer Nature, 2002. https://doi.org/10.1038/nature01170.
ieee: J. C. Coates and M. de Bono, “Antagonistic pathways in neurons exposed to
body fluid regulate social feeding in Caenorhabditis elegans,” Nature,
vol. 419, no. 6910. Springer Nature, pp. 925–929, 2002.
ista: Coates JC, de Bono M. 2002. Antagonistic pathways in neurons exposed to body
fluid regulate social feeding in Caenorhabditis elegans. Nature. 419(6910), 925–929.
mla: Coates, Juliet C., and Mario de Bono. “Antagonistic Pathways in Neurons Exposed
to Body Fluid Regulate Social Feeding in Caenorhabditis Elegans.” Nature,
vol. 419, no. 6910, Springer Nature, 2002, pp. 925–29, doi:10.1038/nature01170.
short: J.C. Coates, M. de Bono, Nature 419 (2002) 925–929.
date_created: 2019-03-21T10:09:20Z
date_published: 2002-10-31T00:00:00Z
date_updated: 2021-01-12T08:06:26Z
day: '31'
doi: 10.1038/nature01170
extern: '1'
external_id:
pmid:
- '12410311'
intvolume: ' 419'
issue: '6910'
language:
- iso: eng
month: '10'
oa_version: None
page: 925-929
pmid: 1
publication: Nature
publication_identifier:
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Antagonistic pathways in neurons exposed to body fluid regulate social feeding
in Caenorhabditis elegans
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 419
year: '2002'
...
---
_id: '6159'
abstract:
- lang: eng
text: 'Natural Caenorhabditis elegans isolates exhibit either social or solitary
feeding on bacteria. We show here that social feeding is induced by nociceptive
neurons that detect adverse or stressful conditions. Ablation of the nociceptive
neurons ASH and ADL transforms social animals into solitary feeders. Social feeding
is probably due to the sensation of noxious chemicals by ASH and ADL neurons;
it requires the genes ocr-2 and osm-9, which encode TRP-related transduction channels,
and odr-4 and odr-8, which are required to localize sensory chemoreceptors to
cilia. Other sensory neurons may suppress social feeding, as social feeding in
ocr-2 and odr-4 mutants is restored by mutations in osm-3, a gene required for
the development of 26 ciliated sensory neurons. Our data suggest a model for regulation
of social feeding by opposing sensory inputs: aversive inputs to nociceptive neurons
promote social feeding, whereas antagonistic inputs from neurons that express
osm-3 inhibit aggregation.'
author:
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
- first_name: David M.
full_name: Tobin, David M.
last_name: Tobin
- first_name: M. Wayne
full_name: Davis, M. Wayne
last_name: Davis
- first_name: Leon
full_name: Avery, Leon
last_name: Avery
- first_name: Cornelia I.
full_name: Bargmann, Cornelia I.
last_name: Bargmann
citation:
ama: de Bono M, Tobin DM, Davis MW, Avery L, Bargmann CI. Social feeding in Caenorhabditis
elegans is induced by neurons that detect aversive stimuli. Nature. 2002;419(6910):899-903.
doi:10.1038/nature01169
apa: de Bono, M., Tobin, D. M., Davis, M. W., Avery, L., & Bargmann, C. I. (2002).
Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive
stimuli. Nature. Springer Nature. https://doi.org/10.1038/nature01169
chicago: Bono, Mario de, David M. Tobin, M. Wayne Davis, Leon Avery, and Cornelia
I. Bargmann. “Social Feeding in Caenorhabditis Elegans Is Induced by Neurons That
Detect Aversive Stimuli.” Nature. Springer Nature, 2002. https://doi.org/10.1038/nature01169.
ieee: M. de Bono, D. M. Tobin, M. W. Davis, L. Avery, and C. I. Bargmann, “Social
feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli,”
Nature, vol. 419, no. 6910. Springer Nature, pp. 899–903, 2002.
ista: de Bono M, Tobin DM, Davis MW, Avery L, Bargmann CI. 2002. Social feeding
in Caenorhabditis elegans is induced by neurons that detect aversive stimuli.
Nature. 419(6910), 899–903.
mla: de Bono, Mario, et al. “Social Feeding in Caenorhabditis Elegans Is Induced
by Neurons That Detect Aversive Stimuli.” Nature, vol. 419, no. 6910, Springer
Nature, 2002, pp. 899–903, doi:10.1038/nature01169.
short: M. de Bono, D.M. Tobin, M.W. Davis, L. Avery, C.I. Bargmann, Nature 419 (2002)
899–903.
date_created: 2019-03-21T10:27:04Z
date_published: 2002-10-31T00:00:00Z
date_updated: 2021-01-12T08:06:27Z
day: '31'
doi: 10.1038/nature01169
extern: '1'
external_id:
pmid:
- '12410303'
intvolume: ' 419'
issue: '6910'
language:
- iso: eng
month: '10'
oa_version: None
page: 899-903
pmid: 1
publication: Nature
publication_identifier:
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Social feeding in Caenorhabditis elegans is induced by neurons that detect
aversive stimuli
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 419
year: '2002'
...
---
_id: '3448'
author:
- first_name: Sanhita
full_name: Mallick, Sanhita
last_name: Mallick
- first_name: Krishnendu
full_name: Krishnendu Chatterjee
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Arif
full_name: Merchant, Arif N
last_name: Merchant
- first_name: Pallab
full_name: Dasgupta, Pallab
last_name: Dasgupta
citation:
ama: 'Mallick S, Chatterjee K, Merchant A, Dasgupta P. Implementation of shape grammar
for plan analysis. In: Elsevier; 2002.'
apa: 'Mallick, S., Chatterjee, K., Merchant, A., & Dasgupta, P. (2002). Implementation
of shape grammar for plan analysis. Presented at the IT-Built: Information Technology
For Built Environment, Elsevier.'
chicago: Mallick, Sanhita, Krishnendu Chatterjee, Arif Merchant, and Pallab Dasgupta.
“Implementation of Shape Grammar for Plan Analysis.” Elsevier, 2002.
ieee: 'S. Mallick, K. Chatterjee, A. Merchant, and P. Dasgupta, “Implementation
of shape grammar for plan analysis,” presented at the IT-Built: Information Technology
For Built Environment, 2002.'
ista: 'Mallick S, Chatterjee K, Merchant A, Dasgupta P. 2002. Implementation of
shape grammar for plan analysis. IT-Built: Information Technology For Built Environment.'
mla: Mallick, Sanhita, et al. Implementation of Shape Grammar for Plan Analysis.
Elsevier, 2002.
short: S. Mallick, K. Chatterjee, A. Merchant, P. Dasgupta, in:, Elsevier, 2002.
conference:
name: 'IT-Built: Information Technology For Built Environment'
date_created: 2018-12-11T12:03:23Z
date_published: 2002-01-15T00:00:00Z
date_updated: 2021-01-12T07:43:31Z
day: '15'
extern: 1
month: '01'
publication_status: published
publisher: Elsevier
publist_id: '2939'
quality_controlled: 0
status: public
title: Implementation of shape grammar for plan analysis
type: conference
year: '2002'
...
---
_id: '3497'
abstract:
- lang: eng
text: The use of advanced patch-clamp recording techniques in brain slices, such
as simultaneous recording from multiple neurons and recording from dendrites or
presynaptic terminals, demands slices of the highest quality. In this context
the mechanics of the tissue slicer are an important factor. Ideally, a tissue
slicer should generate large-amplitude and high-frequency movements of the cutting
blade in a horizontal axis, with minimal vibrations in the vertical axis. We developed
a vibroslicer that fulfils these in part conflicting requirements. The oscillator
is a permanent-magnet-coil-leaf-spring system. Using an auto-resonant mechano-electrical
feedback circuit, large horizontal oscillations (up to 3 mm peak-to-peak) with
high frequency (,90 Hz) are generated. To minimize vertical vibrations, an adjustment
mechanism was employed that allowed alignment of the cutting edge of the blade
with the major axis of the oscillation. A vibroprobe device was used to monitor
vertical vibrations during adjustment. The system is based on the shading of the
light path between a light-emitting diode (LED) and a photodiode. Vibroprobe monitoring
revealed that the vibroslicer, after appropriate adjustment, generated vertical
vibrations of <1 µm, significantly less than many commercial tissue slicers.
Light- and electron-microscopic analysis of surface layers of slices cut with
the vibroslicer showed that cellular elements, dendritic processes and presynaptic
terminals are well preserved under these conditions, as required for patch-clamp
recording from these structures.
acknowledgement: "We thank Dr. M. Frotscher for reading the manuscript, and H. Kressner,
R. Laufersweiler, and A. Bühler for help with the construction of several prototypes
of vibroslicer and vibroprobe. We also thank A. Blomenkamp, K. Winterhalter, B.
Joch, and A. Schneider for technical assistance. This work was supported by grants
of the Deutsche Forschungsgemeinschaft\r\n(SFB 505/C5, C6) and the Human Frontiers
Science Program Organization (RG0017/1998-B)."
article_processing_charge: No
article_type: original
author:
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Joseph
full_name: Bischofberger, Joseph
last_name: Bischofberger
- first_name: Imre
full_name: Vida, Imre
last_name: Vida
- first_name: Ulrich
full_name: Fröbe, Ulrich
last_name: Fröbe
- first_name: S
full_name: Pfitzinger, S
last_name: Pfitzinger
- first_name: H.
full_name: Weber, H.
last_name: Weber
- first_name: Klaus
full_name: Haverkampf, Klaus
last_name: Haverkampf
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: 'Geiger J, Bischofberger J, Vida I, et al. Patch-clamp recording in brain slices
with improved slicer technology. Pflugers Archiv : European Journal of Physiology.
2002;443(3):491-501. doi:10.1007/s00424-001-0735-3'
apa: 'Geiger, J., Bischofberger, J., Vida, I., Fröbe, U., Pfitzinger, S., Weber,
H., … Jonas, P. M. (2002). Patch-clamp recording in brain slices with improved
slicer technology. Pflugers Archiv : European Journal of Physiology. Springer.
https://doi.org/10.1007/s00424-001-0735-3'
chicago: 'Geiger, Jörg, Joseph Bischofberger, Imre Vida, Ulrich Fröbe, S Pfitzinger,
H. Weber, Klaus Haverkampf, and Peter M Jonas. “Patch-Clamp Recording in Brain
Slices with Improved Slicer Technology.” Pflugers Archiv : European Journal
of Physiology. Springer, 2002. https://doi.org/10.1007/s00424-001-0735-3.'
ieee: 'J. Geiger et al., “Patch-clamp recording in brain slices with improved
slicer technology,” Pflugers Archiv : European Journal of Physiology, vol.
443, no. 3. Springer, pp. 491–501, 2002.'
ista: 'Geiger J, Bischofberger J, Vida I, Fröbe U, Pfitzinger S, Weber H, Haverkampf
K, Jonas PM. 2002. Patch-clamp recording in brain slices with improved slicer
technology. Pflugers Archiv : European Journal of Physiology. 443(3), 491–501.'
mla: 'Geiger, Jörg, et al. “Patch-Clamp Recording in Brain Slices with Improved
Slicer Technology.” Pflugers Archiv : European Journal of Physiology, vol.
443, no. 3, Springer, 2002, pp. 491–501, doi:10.1007/s00424-001-0735-3.'
short: 'J. Geiger, J. Bischofberger, I. Vida, U. Fröbe, S. Pfitzinger, H. Weber,
K. Haverkampf, P.M. Jonas, Pflugers Archiv : European Journal of Physiology 443
(2002) 491–501.'
date_created: 2018-12-11T12:03:38Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-07-17T07:36:37Z
day: '01'
doi: 10.1007/s00424-001-0735-3
extern: '1'
external_id:
pmid:
- '11810221'
intvolume: ' 443'
issue: '3'
language:
- iso: eng
month: '01'
oa_version: None
page: 491 - 501
pmid: 1
publication: 'Pflugers Archiv : European Journal of Physiology'
publication_identifier:
issn:
- 0031-6768
publication_status: published
publisher: Springer
publist_id: '2890'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Patch-clamp recording in brain slices with improved slicer technology
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 443
year: '2002'
...
---
_id: '3508'
abstract:
- lang: eng
text: A method of automatic conversion of a physical object into a three-dimensional
digital model. The method acquires a set of measured data points on the surface
of a physical model. From the measured data points, the method reconstructs a
digital model of the physical object using a Delaunay complex of the points, a
flow strcuture of the simplicies in the Delaunay complex and retracting the Delaunay
complex into a digital model of the physical object using the flow structure.
The method then outputs the digital model of the physical object.
applicant:
- Raindrop Geomagic, Inc.
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Ping
full_name: Fu, Ping
last_name: Fu
citation:
ama: Edelsbrunner H, Fu P. Methods of generating three-dimensional digital models
of objects by wrapping point cloud data points. 2002.
apa: Edelsbrunner, H., & Fu, P. (2002). Methods of generating three-dimensional
digital models of objects by wrapping point cloud data points.
chicago: Edelsbrunner, Herbert, and Ping Fu. “Methods of Generating Three-Dimensional
Digital Models of Objects by Wrapping Point Cloud Data Points,” 2002.
ieee: H. Edelsbrunner and P. Fu, “Methods of generating three-dimensional digital
models of objects by wrapping point cloud data points.” 2002.
ista: Edelsbrunner H, Fu P. 2002. Methods of generating three-dimensional digital
models of objects by wrapping point cloud data points.
mla: Edelsbrunner, Herbert, and Ping Fu. Methods of Generating Three-Dimensional
Digital Models of Objects by Wrapping Point Cloud Data Points. 2002.
short: H. Edelsbrunner, P. Fu, (2002).
date_created: 2018-12-11T12:03:42Z
date_published: 2002-04-23T00:00:00Z
date_updated: 2022-01-05T14:09:36Z
day: '23'
extern: '1'
ipc: G16Z99/00 ; G06K9/28 ; G06T17/10 ; G06T17/20
ipn: US6377865B1
main_file_link:
- open_access: '1'
url: https://patents.google.com/patent/US6377865B1
month: '04'
oa: 1
oa_version: Published Version
publication_date: 2002-04-23
publist_id: '2879'
status: public
title: Methods of generating three-dimensional digital models of objects by wrapping
point cloud data points
type: patent
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2002'
...
---
_id: '3533'
abstract:
- lang: eng
text: 'Information in neuronal networks is thought to be represented by the rate
of discharge and the temporal relationship between the discharging neurons. The
discharge frequency of neurons is affected by their afferents and intrinsic properties,
and shows great individual variability. The temporal coordination of neurons is
greatly facilitated by network oscillations. In the hippocampus, population synchrony
fluctuates during theta and gamma oscillations (10-100 ms scale) and can increase
almost 10-fold during sharp wave bursts. Despite these large changes in excitability
in the sub-second scale, longer-term (minute-scale) firing rates of individual
neurons are relatively constant in an unchanging environment. As a result, mean
hippocampal output remains stable over time. To understand the mechanisms responsible
for this homeostasis, we address the following issues: (i) Can firing rates of
single cells be modified? (ii) Once modified, what mechanism(s) can maintain the
changes? We show that firing rates of hippocampal pyramidal cells can be altered
in a novel environment and by Hebbian pairing of physiological input patterns
with postsynaptic burst discharge. We also illustrate a competition between single
spikes and the occurrence of spike bursts. Since spike-inducing (suprathreshold)
inputs decrease the ability of strong (''teaching'') inputs to induce a burst
discharge, we propose that the single spike versus burst competition presents
a homeostatic regulatory mechanism to maintain synaptic strength and, consequently,
firing rate in pyramidal cells.'
article_processing_charge: No
article_type: original
author:
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: George
full_name: Dragoi, George
last_name: Dragoi
- first_name: Kenneth
full_name: Harris, Kenneth
last_name: Harris
- first_name: D.
full_name: Henze, D.
last_name: Henze
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
citation:
ama: Buzsáki G, Csicsvari JL, Dragoi G, Harris K, Henze D, Hirase H. Homeostatic
maintenance of neuronal excitability by burst discharges in vivo. Cerebral
Cortex. 2002;12(9):893-899. doi:10.1093/cercor/12.9.893
apa: Buzsáki, G., Csicsvari, J. L., Dragoi, G., Harris, K., Henze, D., & Hirase,
H. (2002). Homeostatic maintenance of neuronal excitability by burst discharges
in vivo. Cerebral Cortex. Oxford University Press. https://doi.org/10.1093/cercor/12.9.893
chicago: Buzsáki, György, Jozsef L Csicsvari, George Dragoi, Kenneth Harris, D.
Henze, and Hajima Hirase. “Homeostatic Maintenance of Neuronal Excitability by
Burst Discharges in Vivo.” Cerebral Cortex. Oxford University Press, 2002.
https://doi.org/10.1093/cercor/12.9.893.
ieee: G. Buzsáki, J. L. Csicsvari, G. Dragoi, K. Harris, D. Henze, and H. Hirase,
“Homeostatic maintenance of neuronal excitability by burst discharges in vivo,”
Cerebral Cortex, vol. 12, no. 9. Oxford University Press, pp. 893–899,
2002.
ista: Buzsáki G, Csicsvari JL, Dragoi G, Harris K, Henze D, Hirase H. 2002. Homeostatic
maintenance of neuronal excitability by burst discharges in vivo. Cerebral Cortex.
12(9), 893–899.
mla: Buzsáki, György, et al. “Homeostatic Maintenance of Neuronal Excitability by
Burst Discharges in Vivo.” Cerebral Cortex, vol. 12, no. 9, Oxford University
Press, 2002, pp. 893–99, doi:10.1093/cercor/12.9.893.
short: G. Buzsáki, J.L. Csicsvari, G. Dragoi, K. Harris, D. Henze, H. Hirase, Cerebral
Cortex 12 (2002) 893–899.
date_created: 2018-12-11T12:03:50Z
date_published: 2002-09-01T00:00:00Z
date_updated: 2023-07-17T07:27:12Z
day: '01'
doi: 10.1093/cercor/12.9.893
extern: '1'
external_id:
pmid:
- '12183388'
intvolume: ' 12'
issue: '9'
language:
- iso: eng
month: '09'
oa_version: None
page: 893 - 899
pmid: 1
publication: Cerebral Cortex
publication_identifier:
issn:
- 1047-3211
publication_status: published
publisher: Oxford University Press
publist_id: '2851'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Homeostatic maintenance of neuronal excitability by burst discharges in vivo
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 12
year: '2002'
...
---
_id: '3621'
abstract:
- lang: eng
text: In 1991, Barton and Turelli developed recursions to describe the evolution
of multilocus systems under arbitrary forms of selection. This article generalizes
their approach to allow for arbitrary modes of inheritance, including diploidy,
polyploidy, sex linkage, cytoplasmic inheritance, and genomic imprinting. The
framework is also extended to allow for other deterministic evolutionary forces,
including migration and mutation. Exact recursions that fully describe the state
of the population are presented; these are implemented in a computer algebra package
(available on the Web at http://helios.bto.ed.ac.uk/evolgen). Despite the generality
of our framework, it can describe evolutionary dynamics exactly by just two equations.
These recursions can be further simplified using a "quasi-linkage equilibrium"
(QLE) approximation. We illustrate the methods by finding the effect of natural
selection, sexual selection, mutation, and migration on the genetic composition
of a population.
article_processing_charge: No
article_type: original
author:
- first_name: Mark
full_name: Kirkpatrick, Mark
last_name: Kirkpatrick
- first_name: Toby
full_name: Johnson, Toby
last_name: Johnson
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Kirkpatrick M, Johnson T, Barton NH. General models of multilocus evolution.
Genetics. 2002;161(4):1727-1750. doi:10.1093/genetics/161.4.1727
apa: Kirkpatrick, M., Johnson, T., & Barton, N. H. (2002). General models of
multilocus evolution. Genetics. Genetics Society of America. https://doi.org/10.1093/genetics/161.4.1727
chicago: Kirkpatrick, Mark, Toby Johnson, and Nicholas H Barton. “General Models
of Multilocus Evolution.” Genetics. Genetics Society of America, 2002.
https://doi.org/10.1093/genetics/161.4.1727.
ieee: M. Kirkpatrick, T. Johnson, and N. H. Barton, “General models of multilocus
evolution,” Genetics, vol. 161, no. 4. Genetics Society of America, pp.
1727–1750, 2002.
ista: Kirkpatrick M, Johnson T, Barton NH. 2002. General models of multilocus evolution.
Genetics. 161(4), 1727–1750.
mla: Kirkpatrick, Mark, et al. “General Models of Multilocus Evolution.” Genetics,
vol. 161, no. 4, Genetics Society of America, 2002, pp. 1727–50, doi:10.1093/genetics/161.4.1727.
short: M. Kirkpatrick, T. Johnson, N.H. Barton, Genetics 161 (2002) 1727–1750.
date_created: 2018-12-11T12:04:17Z
date_published: 2002-08-01T00:00:00Z
date_updated: 2023-07-11T13:20:26Z
day: '01'
doi: 10.1093/genetics/161.4.1727
extern: '1'
external_id:
pmid:
- '12196414'
intvolume: ' 161'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462196/
month: '08'
oa: 1
oa_version: Published Version
page: 1727 - 1750
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '2762'
quality_controlled: '1'
scopus_import: '1'
status: public
title: General models of multilocus evolution
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 161
year: '2002'
...
---
_id: '3757'
abstract:
- lang: eng
text: A central problem in biology is determining how genes interact as parts of
functional networks. Creation and analysis of synthetic networks, composed of
well-characterized genetic elements, provide a framework for theoretical modeling.
Here, with the use of a combinatorial method, a library of networks with varying
connectivity was generated in Escherichia coli. These networks were composed of
genes encoding the transcriptional regulators Lacl, TetR, and lambda Cl, as well
as the corresponding promoters. They displayed phenotypic behaviors resembling
binary logical circuits, with two chemical “inputs” and a fluorescent protein
“output.” Within this simple system, diverse computational functions arose through
changes in network connectivity. Combinatorial synthesis provides an alternative
approach for studying biological networks, as well as an efficient method for
producing diverse phenotypes in vivo.
article_processing_charge: No
article_type: original
author:
- first_name: Calin C
full_name: Guet, Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
- first_name: Michael
full_name: Elowitz, Michael
last_name: Elowitz
- first_name: Weihong
full_name: Hsing, Weihong
last_name: Hsing
- first_name: Stanislas
full_name: Leibler, Stanislas
last_name: Leibler
citation:
ama: Guet CC, Elowitz M, Hsing W, Leibler S. Combinatorial synthesis of genetic
networks. Science. 2002;296(5572):1466-1470. doi:10.1126/science.1067407
apa: Guet, C. C., Elowitz, M., Hsing, W., & Leibler, S. (2002). Combinatorial
synthesis of genetic networks. Science. American Association for the Advancement
of Science. https://doi.org/10.1126/science.1067407
chicago: Guet, Calin C, Michael Elowitz, Weihong Hsing, and Stanislas Leibler. “Combinatorial
Synthesis of Genetic Networks.” Science. American Association for the Advancement
of Science, 2002. https://doi.org/10.1126/science.1067407.
ieee: C. C. Guet, M. Elowitz, W. Hsing, and S. Leibler, “Combinatorial synthesis
of genetic networks,” Science, vol. 296, no. 5572. American Association
for the Advancement of Science, pp. 1466–1470, 2002.
ista: Guet CC, Elowitz M, Hsing W, Leibler S. 2002. Combinatorial synthesis of genetic
networks. Science. 296(5572), 1466–1470.
mla: Guet, Calin C., et al. “Combinatorial Synthesis of Genetic Networks.” Science,
vol. 296, no. 5572, American Association for the Advancement of Science, 2002,
pp. 1466–70, doi:10.1126/science.1067407.
short: C.C. Guet, M. Elowitz, W. Hsing, S. Leibler, Science 296 (2002) 1466–1470.
date_created: 2018-12-11T12:05:00Z
date_published: 2002-05-24T00:00:00Z
date_updated: 2023-07-11T12:48:53Z
day: '24'
doi: 10.1126/science.1067407
extern: '1'
external_id:
pmid:
- '12029133'
intvolume: ' 296'
issue: '5572'
language:
- iso: eng
month: '05'
oa_version: None
page: 1466 - 1470
pmid: 1
publication: Science
publication_identifier:
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '2471'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Combinatorial synthesis of genetic networks
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 296
year: '2002'
...
---
_id: '3799'
abstract:
- lang: eng
text: 'GABAergic interneurones are diverse in their morphological and functional
properties. Perisomatic inhibitory cells show fast spiking during sustained current
injection, whereas dendritic inhibitory cells fire action potentials with lower
frequency. We examined functional and molecular properties of K(+) channels in
interneurones with horizontal dendrites in stratum oriens-alveus (OA) of the hippocampal
CA1 region, which mainly comprise somatostatin-positive dendritic inhibitory cells.
Voltage-gated K(+) currents in nucleated patches isolated from OA interneurones
consisted of three major components: a fast delayed rectifier K(+) current component
that was highly sensitive to external 4-aminopyridine (4-AP) and tetraethylammonium
(TEA) (half-maximal inhibitory concentrations < 0.1 mM for both blockers),
a slow delayed rectifier K(+) current component that was sensitive to high concentrations
of TEA, but insensitive to 4-AP, and a rapidly inactivating A-type K(+) current
component that was blocked by high concentrations of 4-AP, but resistant to TEA.
The relative contributions of these components to the macroscopic K(+) current
were estimated as 57 +/- 5, 25 +/- 6, and 19 +/- 2 %, respectively. Dendrotoxin,
a selective blocker of Kv1 channels had only minimal effects on K(+) currents
in nucleated patches. Coapplication of the membrane-permeant cAMP analogue 8-(4-chlorophenylthio)-adenosine
3'':5''-cyclic monophosphate (cpt-cAMP) and the phosphodiesterase blocker isobutyl-methylxanthine
(IBMX) resulted in a selective inhibition of the fast delayed rectifier K(+) current
component. This inhibition was absent in the presence of the protein kinase A
(PKA) inhibitor H-89, implying the involvement of PKA-mediated phosphorylation.
Single-cell reverse transcription-polymerase chain reaction (RT-PCR) analysis
revealed a high abundance of Kv3.2 mRNA in OA interneurones, whereas the expression
level of Kv3.1 mRNA was markedly lower. Similarly, RT-PCR analysis showed a high
abundance of Kv4.3 mRNA, whereas Kv4.2 mRNA was undetectable. This suggests that
the fast delayed rectifier K(+) current and the A-type K(+) current component
are mediated predominantly by homomeric Kv3.2 and Kv4.3 channels. Selective modulation
of Kv3.2 channels in OA interneurones by cAMP is likely to be an important factor
regulating the activity of dendritic inhibitory cells in principal neurone-interneurone
microcircuits.'
acknowledgement: We thank Drs J. Bischofberger, M. Heckmann, and I. Vida for critically
reading the manuscript, and A. Blomenkamp and K. Winterhalter for technical assistance.
This work was supported by a scholarship from the Deutscher Akademischer Austansch
dienst to C.-C. L., a Deutsche Forschungsgemeinschaft grant to P. J. (SFB 505/C5),
and the Alexander-von-Humboldt foundation.
article_processing_charge: No
article_type: original
author:
- first_name: Cheng
full_name: Lien, Cheng
last_name: Lien
- first_name: Marco
full_name: Martina, Marco
last_name: Martina
- first_name: Jobst
full_name: Schultz, Jobst
last_name: Schultz
- first_name: Heimo
full_name: Ehmke, Heimo
last_name: Ehmke
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Lien C, Martina M, Schultz J, Ehmke H, Jonas PM. Gating, modulation and subunit
composition of voltage-gated K(+) channels in dendritic inhibitory interneurones
of rat hippocampus. Journal of Physiology. 2002;538(Pt 2):405-419. doi:10.1113/jphysiol.2001.013066
apa: Lien, C., Martina, M., Schultz, J., Ehmke, H., & Jonas, P. M. (2002). Gating,
modulation and subunit composition of voltage-gated K(+) channels in dendritic
inhibitory interneurones of rat hippocampus. Journal of Physiology. Wiley-Blackwell.
https://doi.org/10.1113/jphysiol.2001.013066
chicago: Lien, Cheng, Marco Martina, Jobst Schultz, Heimo Ehmke, and Peter M Jonas.
“Gating, Modulation and Subunit Composition of Voltage-Gated K(+) Channels in
Dendritic Inhibitory Interneurones of Rat Hippocampus.” Journal of Physiology.
Wiley-Blackwell, 2002. https://doi.org/10.1113/jphysiol.2001.013066.
ieee: C. Lien, M. Martina, J. Schultz, H. Ehmke, and P. M. Jonas, “Gating, modulation
and subunit composition of voltage-gated K(+) channels in dendritic inhibitory
interneurones of rat hippocampus,” Journal of Physiology, vol. 538, no.
Pt 2. Wiley-Blackwell, pp. 405–419, 2002.
ista: Lien C, Martina M, Schultz J, Ehmke H, Jonas PM. 2002. Gating, modulation
and subunit composition of voltage-gated K(+) channels in dendritic inhibitory
interneurones of rat hippocampus. Journal of Physiology. 538(Pt 2), 405–419.
mla: Lien, Cheng, et al. “Gating, Modulation and Subunit Composition of Voltage-Gated
K(+) Channels in Dendritic Inhibitory Interneurones of Rat Hippocampus.” Journal
of Physiology, vol. 538, no. Pt 2, Wiley-Blackwell, 2002, pp. 405–19, doi:10.1113/jphysiol.2001.013066.
short: C. Lien, M. Martina, J. Schultz, H. Ehmke, P.M. Jonas, Journal of Physiology
538 (2002) 405–419.
date_created: 2018-12-11T12:05:14Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-07-11T12:32:26Z
day: '01'
doi: 10.1113/jphysiol.2001.013066
extern: '1'
external_id:
pmid:
- '11790809'
intvolume: ' 538'
issue: Pt 2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290075/
month: '01'
oa: 1
oa_version: Published Version
page: 405 - 419
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2411'
quality_controlled: '1'
status: public
title: Gating, modulation and subunit composition of voltage-gated K(+) channels in
dendritic inhibitory interneurones of rat hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 538
year: '2002'
...
---
_id: '3800'
abstract:
- lang: eng
text: Networks of GABAergic interneurons are of critical importance for the generation
of gamma frequency oscillations in the brain. To examine the underlying synaptic
mechanisms, we made paired recordings from "basket cells" (BCs) in different
subfields of hippocampal slices, using transgenic mice that express enhanced green
fluorescent protein (EGFP) under the control of the parvalbumin promoter. Unitary
inhibitory postsynaptic currents (IPSCs) showed large amplitude and fast time
course with mean amplitude-weighted decay time constants of 2.5, 1.2, and 1.8
ms in the dentate gyrus, and the cornu ammonis area 3 (CA3) and 1 (CA1), respectively
(33-34 degrees C). The decay of unitary IPSCs at BC-BC synapses was significantly
faster than that at BC-principal cell synapses, indicating target cell-specific
differences in IPSC kinetics. In addition, electrical coupling was found in a
subset of BC-BC pairs. To examine whether an interneuron network with fast inhibitory
synapses can act as a gamma frequency oscillator, we developed an interneuron
network model based on experimentally determined properties. In comparison to
previous interneuron network models, our model was able to generate oscillatory
activity with higher coherence over a broad range of frequencies (20-110 Hz).
In this model, high coherence and flexibility in frequency control emerge from
the combination of synaptic properties, network structure, and electrical coupling.
acknowledgement: We thank Drs. J. Bischofberger, M. Heckmann, and R. Traub for critically
reading the manuscript. This work was supported by Deutsche Forschungsgemeinschaft
Grants SFB 505/C5 (to P.J.) and SFB 505/C6 (to M.F. and P.J.), Human Frontiers Science
Program Organization Grant RG0017/1998-B (to P.J.), and grants from the Alexander-von-Humboldt
Foundation (to P.J. and M.F.), the Schilling Foundation (to H.M.), and Novartis
(to H.M.).
article_processing_charge: No
article_type: original
author:
- first_name: Marlene
full_name: Bartos, Marlene
last_name: Bartos
- first_name: Imre
full_name: Vida, Imre
last_name: Vida
- first_name: Michael
full_name: Frotscher, Michael
last_name: Frotscher
- first_name: Axel
full_name: Meyer, Axel
last_name: Meyer
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Bartos M, Vida I, Frotscher M, et al. Fast synaptic inhibition promotes synchronized
gamma oscillations in hippocampal interneuron networks. PNAS. 2002;99(20):13222-13227.
doi:10.1073/pnas.192233099
apa: Bartos, M., Vida, I., Frotscher, M., Meyer, A., Monyer, H., Geiger, J., &
Jonas, P. M. (2002). Fast synaptic inhibition promotes synchronized gamma oscillations
in hippocampal interneuron networks. PNAS. National Academy of Sciences.
https://doi.org/10.1073/pnas.192233099
chicago: Bartos, Marlene, Imre Vida, Michael Frotscher, Axel Meyer, Hannah Monyer,
Jörg Geiger, and Peter M Jonas. “Fast Synaptic Inhibition Promotes Synchronized
Gamma Oscillations in Hippocampal Interneuron Networks.” PNAS. National
Academy of Sciences, 2002. https://doi.org/10.1073/pnas.192233099.
ieee: M. Bartos et al., “Fast synaptic inhibition promotes synchronized gamma
oscillations in hippocampal interneuron networks,” PNAS, vol. 99, no. 20.
National Academy of Sciences, pp. 13222–13227, 2002.
ista: Bartos M, Vida I, Frotscher M, Meyer A, Monyer H, Geiger J, Jonas PM. 2002.
Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal
interneuron networks. PNAS. 99(20), 13222–13227.
mla: Bartos, Marlene, et al. “Fast Synaptic Inhibition Promotes Synchronized Gamma
Oscillations in Hippocampal Interneuron Networks.” PNAS, vol. 99, no. 20,
National Academy of Sciences, 2002, pp. 13222–27, doi:10.1073/pnas.192233099.
short: M. Bartos, I. Vida, M. Frotscher, A. Meyer, H. Monyer, J. Geiger, P.M. Jonas,
PNAS 99 (2002) 13222–13227.
date_created: 2018-12-11T12:05:14Z
date_published: 2002-09-16T00:00:00Z
date_updated: 2023-07-10T13:35:18Z
day: '16'
doi: 10.1073/pnas.192233099
extern: '1'
external_id:
pmid:
- '12235359'
intvolume: ' 99'
issue: '20'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130614/
month: '09'
oa: 1
oa_version: Published Version
page: 13222 - 13227
pmid: 1
publication: PNAS
publication_identifier:
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
publist_id: '2409'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal
interneuron networks
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 99
year: '2002'
...
---
_id: '3801'
abstract:
- lang: eng
text: 'To examine possible interactions between fast depression and modulation of
inhibitory synaptic transmission in the hippocampus, we recorded from pairs of
synaptically connected basket cells (BCs) and granule cells (GCs) in the dentate
gyrus of rat brain slices at 34 degrees C. Multiple-pulse depression (MPD) was
examined in trains of 5 or 10 inhibitory postsynaptic currents (IPSCs) evoked
at frequencies of 10-100 Hz under several conditions that inhibit transmitter
release: block of voltage-dependent Ca2+ channels by Cd2+ (10 microM), activation
of gamma-amino-butyric acid type B receptors (GABA(B)Rs) by baclofen (10 microM)
and activation of muscarinic acetylcholine receptors (mAchRs) by carbachol (2
microM). All manipulations led to a substantial inhibition of synaptic transmission,
reducing the amplitude of the first IPSC in the train (IPSC1) by 72%, 61% and
29%, respectively. However, MPD was largely preserved under these conditions (0.34
in control versus 0.31, 0.50 and 0.47 in the respective conditions at 50 Hz).
Similarly, a theta burst stimulation (TBS) protocol reduced IPSC1 by 54%, but
left MPD unchanged (0.40 in control and 0.39 during TBS). Analysis of both fractions
of transmission failures and coefficients of variation (CV) of IPSC peak amplitudes
suggested that MPD had a presynaptic expression site, independent of release probability.
In conclusion, different types of presynaptic modulation of inhibitory synaptic
transmission converge on a reduction of synaptic strength, while short-term dynamics
are largely unchanged.'
acknowledgement: We thank Drs M. Bartos, J. Bischofberger, M. Heckmann and
I. Vida for critically reading the manuscript, Dr K. Götz for providing information about pharmacological properties of
inhibitory hippocampal synapses, and A. Blomenkamp and K. Winterhalter for
technical assistance. This work was supported by Deutsche Forschungsgemeinschaft
grants to P.J. (Jo-248/2-2,SFB 505/C5) and the Alexander-von-Humboldt foundation.
article_processing_charge: No
article_type: original
author:
- first_name: Stefan
full_name: Hefft, Stefan
last_name: Hefft
- first_name: Udo
full_name: Kraushaar, Udo
last_name: Kraushaar
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Hefft S, Kraushaar U, Geiger J, Jonas PM. Presynaptic short-term depression
is maintained during regulation of transmitter release at a GABAergic synapse
in rat hippocampus. Journal of Physiology. 2002;539(Pt 1):201-208. doi:10.1113/jphysiol.2001.013455
apa: Hefft, S., Kraushaar, U., Geiger, J., & Jonas, P. M. (2002). Presynaptic
short-term depression is maintained during regulation of transmitter release at
a GABAergic synapse in rat hippocampus. Journal of Physiology. Wiley-Blackwell.
https://doi.org/10.1113/jphysiol.2001.013455
chicago: Hefft, Stefan, Udo Kraushaar, Jörg Geiger, and Peter M Jonas. “Presynaptic
Short-Term Depression Is Maintained during Regulation of Transmitter Release at
a GABAergic Synapse in Rat Hippocampus.” Journal of Physiology. Wiley-Blackwell,
2002. https://doi.org/10.1113/jphysiol.2001.013455.
ieee: S. Hefft, U. Kraushaar, J. Geiger, and P. M. Jonas, “Presynaptic short-term
depression is maintained during regulation of transmitter release at a GABAergic
synapse in rat hippocampus,” Journal of Physiology, vol. 539, no. Pt 1.
Wiley-Blackwell, pp. 201–8, 2002.
ista: Hefft S, Kraushaar U, Geiger J, Jonas PM. 2002. Presynaptic short-term depression
is maintained during regulation of transmitter release at a GABAergic synapse
in rat hippocampus. Journal of Physiology. 539(Pt 1), 201–8.
mla: Hefft, Stefan, et al. “Presynaptic Short-Term Depression Is Maintained during
Regulation of Transmitter Release at a GABAergic Synapse in Rat Hippocampus.”
Journal of Physiology, vol. 539, no. Pt 1, Wiley-Blackwell, 2002, pp. 201–08,
doi:10.1113/jphysiol.2001.013455.
short: S. Hefft, U. Kraushaar, J. Geiger, P.M. Jonas, Journal of Physiology 539
(2002) 201–8.
date_created: 2018-12-11T12:05:15Z
date_published: 2002-02-01T00:00:00Z
date_updated: 2023-07-11T10:01:12Z
day: '01'
doi: 10.1113/jphysiol.2001.013455
extern: '1'
external_id:
pmid:
- '11850513'
intvolume: ' 539'
issue: Pt 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290140/
month: '02'
oa: 1
oa_version: Published Version
page: 201 - 8
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2410'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Presynaptic short-term depression is maintained during regulation of transmitter
release at a GABAergic synapse in rat hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 539
year: '2002'
...
---
_id: '3802'
abstract:
- lang: eng
text: The presynaptic Ca2+ signal is a key determinant of transmitter release at
chemical synapses. In cortical synaptic terminals, however, little is known about
the kinetic properties of the presynaptic Ca2+ channels. To investigate the timing
and magnitude of the presynaptic Ca2+ inflow, we performed whole-cell patch-clamp
recordings from mossy fiber boutons (MFBs) in rat hippocampus. MFBs showed large
high-voltage-activated Ca(2+) currents, with a maximal amplitude of approximately
100 pA at a membrane potential of 0 mV. Both activation and deactivation were
fast, with time constants in the submillisecond range at a temperature of approximately
23 degrees C. An MFB action potential (AP) applied as a voltage-clamp command
evoked a transient Ca2+ current with an average amplitude of approximately 170
pA and a half-duration of 580 microsec. A prepulse to +40 mV had only minimal
effects on the AP-evoked Ca2+ current, indicating that presynaptic APs open the
voltage-gated Ca2+ channels very effectively. On the basis of the experimental
data, we developed a kinetic model with four closed states and one open state,
linked by voltage-dependent rate constants. Simulations of the Ca2+ current could
reproduce the experimental data, including the large amplitude and rapid time
course of the current evoked by MFB APs. Furthermore, the simulations indicate
that the shape of the presynaptic AP and the gating kinetics of the Ca2+ channels
are tuned to produce a maximal Ca2+ influx during a minimal period of time. The
precise timing and high efficacy of Ca2+ channel activation at this cortical glutamatergic
synapse may be important for synchronous transmitter release and temporal information
processing.
acknowledgement: J.B. was supported by grants from the Deutsche Forschungsgemeinschaft
(Bi 642/1-2 and SFB 505/C9). We thank Dr. U. Kraushaar, Dr. S. Hefft, and C. Schmidt-Hieber
for critically reading this manuscript, F. Heyde for secretarial help, and A. Blomenkamp
and K. Winterhalter for technical assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Josef
full_name: Bischofberger, Josef
last_name: Bischofberger
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Bischofberger J, Geiger J, Jonas PM. Timing and efficacy of Ca(2+) channel
activation in hippocampal mossy fiber boutons. Journal of Neuroscience.
2002;22(24):10593-10602. doi:10.1523/JNEUROSCI.22-24-10593.2002
apa: Bischofberger, J., Geiger, J., & Jonas, P. M. (2002). Timing and efficacy
of Ca(2+) channel activation in hippocampal mossy fiber boutons. Journal of
Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002
chicago: Bischofberger, Josef, Jörg Geiger, and Peter M Jonas. “Timing and Efficacy
of Ca(2+) Channel Activation in Hippocampal Mossy Fiber Boutons.” Journal of
Neuroscience. Society for Neuroscience, 2002. https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002.
ieee: J. Bischofberger, J. Geiger, and P. M. Jonas, “Timing and efficacy of Ca(2+)
channel activation in hippocampal mossy fiber boutons,” Journal of Neuroscience,
vol. 22, no. 24. Society for Neuroscience, pp. 10593–10602, 2002.
ista: Bischofberger J, Geiger J, Jonas PM. 2002. Timing and efficacy of Ca(2+) channel
activation in hippocampal mossy fiber boutons. Journal of Neuroscience. 22(24),
10593–10602.
mla: Bischofberger, Josef, et al. “Timing and Efficacy of Ca(2+) Channel Activation
in Hippocampal Mossy Fiber Boutons.” Journal of Neuroscience, vol. 22,
no. 24, Society for Neuroscience, 2002, pp. 10593–602, doi:10.1523/JNEUROSCI.22-24-10593.2002.
short: J. Bischofberger, J. Geiger, P.M. Jonas, Journal of Neuroscience 22 (2002)
10593–10602.
date_created: 2018-12-11T12:05:15Z
date_published: 2002-12-01T00:00:00Z
date_updated: 2023-06-13T13:19:45Z
day: '01'
doi: 10.1523/JNEUROSCI.22-24-10593.2002
extern: '1'
external_id:
pmid:
- '12486151'
intvolume: ' 22'
issue: '24'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758411/
month: '12'
oa: 1
oa_version: Published Version
page: 10593 - 10602
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2407'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber
boutons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 22
year: '2002'
...
---
_id: '3803'
abstract:
- lang: eng
text: Mossy fiber (MF) synapses are key stations for flow of information through
the hippocampal formation. A major component of the output of the MF system is
directed towards inhibitory interneurons. Recent studies have revealed that the
functional properties of MF-interneuron synapses differ substantially from those
of MF-CA3 pyramidal neuron synapses. Mossy-fiber-interneuron synapses in the stratum
lucidum represent a continuum of functional subtypes, in which the subunit composition
of postsynaptic AMPA receptors and NMDA receptors appears to be regulated in a
coordinated manner.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Josef
full_name: Bischofberger, Josef
last_name: Bischofberger
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: 'Bischofberger J, Jonas PM. TwoB or not twoB: differential transmission at
glutamatergic mossy fiber-interneuron synapses in the hippocampus. Trends in
Neurosciences. 2002;25(12):600-603. doi:10.1016/S0166-2236(02)02259-2'
apa: 'Bischofberger, J., & Jonas, P. M. (2002). TwoB or not twoB: differential
transmission at glutamatergic mossy fiber-interneuron synapses in the hippocampus.
Trends in Neurosciences. Elsevier. https://doi.org/10.1016/S0166-2236(02)02259-2'
chicago: 'Bischofberger, Josef, and Peter M Jonas. “TwoB or Not TwoB: Differential
Transmission at Glutamatergic Mossy Fiber-Interneuron Synapses in the Hippocampus.”
Trends in Neurosciences. Elsevier, 2002. https://doi.org/10.1016/S0166-2236(02)02259-2.'
ieee: 'J. Bischofberger and P. M. Jonas, “TwoB or not twoB: differential transmission
at glutamatergic mossy fiber-interneuron synapses in the hippocampus,” Trends
in Neurosciences, vol. 25, no. 12. Elsevier, pp. 600–603, 2002.'
ista: 'Bischofberger J, Jonas PM. 2002. TwoB or not twoB: differential transmission
at glutamatergic mossy fiber-interneuron synapses in the hippocampus. Trends in
Neurosciences. 25(12), 600–603.'
mla: 'Bischofberger, Josef, and Peter M. Jonas. “TwoB or Not TwoB: Differential
Transmission at Glutamatergic Mossy Fiber-Interneuron Synapses in the Hippocampus.”
Trends in Neurosciences, vol. 25, no. 12, Elsevier, 2002, pp. 600–03, doi:10.1016/S0166-2236(02)02259-2.'
short: J. Bischofberger, P.M. Jonas, Trends in Neurosciences 25 (2002) 600–603.
date_created: 2018-12-11T12:05:15Z
date_published: 2002-12-01T00:00:00Z
date_updated: 2023-07-10T13:22:24Z
day: '01'
doi: 10.1016/S0166-2236(02)02259-2
extern: '1'
external_id:
pmid:
- '12446120'
intvolume: ' 25'
issue: '12'
language:
- iso: eng
month: '12'
oa_version: None
page: 600 - 603
pmid: 1
publication: Trends in Neurosciences
publication_identifier:
issn:
- 0166-2236
publication_status: published
publisher: Elsevier
publist_id: '2408'
quality_controlled: '1'
status: public
title: 'TwoB or not twoB: differential transmission at glutamatergic mossy fiber-interneuron
synapses in the hippocampus'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 25
year: '2002'
...
---
_id: '3919'
abstract:
- lang: eng
text: Hamilton's concept of local mate competition (LMC) is the standard model to
explain female-biased sex ratios in solitary Hymenoptera. In social Hymenoptera,
however, LMC has remained controversial, mainly because manipulation of sex allocation
by workers in response to relatedness asymmetries is an additional powerful mechanism
of female bias. Furthermore, the predominant mating systems in the social insects
are thought to make LMC unlikely. Nevertheless, several species exist in which
dispersal of males is limited and mating occurs in the nest. Some of these species,
such as the ant Cardiocondyla obscurior, have evolved dimorphic males, with one
morph being specialized for dispersal and the other for fighting with nest-mate
males over access to females. Such life history, combining sociality and alternative
reproductive tactics in males, provides a unique opportunity to test the power
of LMC as a selective force leading to female-biased sex ratios in social Hymenoptera.
We show that, in concordance with LMC predictions, an experimental increase in
queen number leads to a shift in sex allocation in favour of non-dispersing males,
but does not influence the proportion of disperser males. Furthermore, we can
assign this change in sex allocation at the colony level to the queens and rule
out worker manipulation.
acknowledgement: 'We thank A. F. G. Bourke, J. J. Boomsma, S. Foitzik, M. Sixt,C.
Anderson and C. Schubart for improving the manuscript, and E. Sixt for ant illustrations (figure 2). This study was
funded by the DFG (Deutsche Forschungsgemeinschaft: He1623/7-2).'
article_processing_charge: No
article_type: original
author:
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
- first_name: Jürgen
full_name: Heinze, Jürgen
last_name: Heinze
citation:
ama: 'Cremer S, Heinze J. Adaptive production of fighter males: queens of the ant
Cardiocondyla adjust the sex ratio under local mate competition. Proceedings
of the Royal Society of London Series B Biological Sciences. 2002;269(1489):417-422.
doi:10.1098/rspb.2001.1892'
apa: 'Cremer, S., & Heinze, J. (2002). Adaptive production of fighter males:
queens of the ant Cardiocondyla adjust the sex ratio under local mate competition.
Proceedings of the Royal Society of London Series B Biological Sciences.
Royal Society, The. https://doi.org/10.1098/rspb.2001.1892'
chicago: 'Cremer, Sylvia, and Jürgen Heinze. “Adaptive Production of Fighter Males:
Queens of the Ant Cardiocondyla Adjust the Sex Ratio under Local Mate Competition.”
Proceedings of the Royal Society of London Series B Biological Sciences.
Royal Society, The, 2002. https://doi.org/10.1098/rspb.2001.1892.'
ieee: 'S. Cremer and J. Heinze, “Adaptive production of fighter males: queens of
the ant Cardiocondyla adjust the sex ratio under local mate competition,” Proceedings
of the Royal Society of London Series B Biological Sciences, vol. 269, no.
1489. Royal Society, The, pp. 417–422, 2002.'
ista: 'Cremer S, Heinze J. 2002. Adaptive production of fighter males: queens of
the ant Cardiocondyla adjust the sex ratio under local mate competition. Proceedings
of the Royal Society of London Series B Biological Sciences. 269(1489), 417–422.'
mla: 'Cremer, Sylvia, and Jürgen Heinze. “Adaptive Production of Fighter Males:
Queens of the Ant Cardiocondyla Adjust the Sex Ratio under Local Mate Competition.”
Proceedings of the Royal Society of London Series B Biological Sciences,
vol. 269, no. 1489, Royal Society, The, 2002, pp. 417–22, doi:10.1098/rspb.2001.1892.'
short: S. Cremer, J. Heinze, Proceedings of the Royal Society of London Series B
Biological Sciences 269 (2002) 417–422.
date_created: 2018-12-11T12:05:53Z
date_published: 2002-02-22T00:00:00Z
date_updated: 2023-06-13T11:52:17Z
day: '22'
doi: 10.1098/rspb.2001.1892
extern: '1'
external_id:
pmid:
- '11886631'
intvolume: ' 269'
issue: '1489'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1690910/
month: '02'
oa: 1
oa_version: None
page: 417 - 422
pmid: 1
publication: Proceedings of the Royal Society of London Series B Biological Sciences
publication_identifier:
issn:
- 0962-8452
publication_status: published
publisher: Royal Society, The
publist_id: '2231'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Adaptive production of fighter males: queens of the ant Cardiocondyla adjust
the sex ratio under local mate competition'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 269
year: '2002'
...