---
_id: '2347'
abstract:
- lang: eng
text: We consider the ground state properties of an inhomogeneous two-dimensional
Bose gas with a repulsive, short range pair interaction and an external confining
potential. In the limit when the particle number N is large but ρ̅a 2 is small,
where ρ̅ is the average particle density and a the scattering length, the ground
state energy and density are rigorously shown to be given to leading order by
a Gross–Pitaevskii (GP) energy functional with a coupling constant g~1/|1n(ρ̅a
2)|. In contrast to the 3D case the coupling constant depends on N through the
mean density. The GP energy per particle depends only on Ng. In 2D this parameter
is typically so large that the gradient term in the GP energy functional is negligible
and the simpler description by a Thomas–Fermi type functional is adequate.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Élliott
full_name: Lieb, Élliott
last_name: Lieb
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
- first_name: Jakob
full_name: Yngvason, Jakob
last_name: Yngvason
citation:
ama: Lieb É, Seiringer R, Yngvason J. A rigorous derivation of the Gross-Pitaevskii
energy functional for a two-dimensional Bose gas. Communications in Mathematical
Physics. 2001;224(1):17-31. doi:10.1007/s002200100533
apa: Lieb, É., Seiringer, R., & Yngvason, J. (2001). A rigorous derivation of
the Gross-Pitaevskii energy functional for a two-dimensional Bose gas. Communications
in Mathematical Physics. Springer. https://doi.org/10.1007/s002200100533
chicago: Lieb, Élliott, Robert Seiringer, and Jakob Yngvason. “A Rigorous Derivation
of the Gross-Pitaevskii Energy Functional for a Two-Dimensional Bose Gas.” Communications
in Mathematical Physics. Springer, 2001. https://doi.org/10.1007/s002200100533.
ieee: É. Lieb, R. Seiringer, and J. Yngvason, “A rigorous derivation of the Gross-Pitaevskii
energy functional for a two-dimensional Bose gas,” Communications in Mathematical
Physics, vol. 224, no. 1. Springer, pp. 17–31, 2001.
ista: Lieb É, Seiringer R, Yngvason J. 2001. A rigorous derivation of the Gross-Pitaevskii
energy functional for a two-dimensional Bose gas. Communications in Mathematical
Physics. 224(1), 17–31.
mla: Lieb, Élliott, et al. “A Rigorous Derivation of the Gross-Pitaevskii Energy
Functional for a Two-Dimensional Bose Gas.” Communications in Mathematical
Physics, vol. 224, no. 1, Springer, 2001, pp. 17–31, doi:10.1007/s002200100533.
short: É. Lieb, R. Seiringer, J. Yngvason, Communications in Mathematical Physics
224 (2001) 17–31.
date_created: 2018-12-11T11:57:08Z
date_published: 2001-11-01T00:00:00Z
date_updated: 2023-05-30T12:28:46Z
day: '01'
doi: 10.1007/s002200100533
extern: '1'
external_id:
arxiv:
- cond-mat/0005026
intvolume: ' 224'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/cond-mat/0005026
month: '11'
oa: 1
oa_version: Published Version
page: 17 - 31
publication: Communications in Mathematical Physics
publication_identifier:
issn:
- 0010-3616
publication_status: published
publisher: Springer
publist_id: '4579'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A rigorous derivation of the Gross-Pitaevskii energy functional for a two-dimensional
Bose gas
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 224
year: '2001'
...
---
_id: '2348'
abstract:
- lang: eng
text: This paper concerns the asymptotic ground state properties of heavy atoms
in strong, homogeneous magnetic fields. In the limit when the nuclear charge Z
tends to ∞ with the magnetic field B satisfying B ≫ Z4/3 all the electrons are
confined to the lowest Landau band. We consider here an energy functional, whose
variable is a sequence of one-dimensional density matrices corresponding to different
angular momentum functions in the lowest Landau band. We study this functional
in detail and derive various interesting properties, which are compared with the
density matrix (DM) theory introduced by Lieb, Solovej and Yngvason. In contrast
to the DM theory the variable perpendicular to the field is replaced by the discrete
angular momentum quantum numbers. Hence we call the new functional a discrete
density matrix (DDM) functional. We relate this DDM theory to the lowest Landau
band quantum mechanics and show that it reproduces correctly the ground state
energy apart from errors due to the indirect part of the Coulomb interaction energy.
acknowledgement: The authors would like to thank Bernhard Baumgartner and Jakob Yngvason
for proofreading and valuable comments.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Christian
full_name: Hainzl, Christian
last_name: Hainzl
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Hainzl C, Seiringer R. A discrete density matrix theory for atoms in strong
magnetic fields. Communications in Mathematical Physics. 2001;217(1):229-248.
doi:10.1007/s002200100373
apa: Hainzl, C., & Seiringer, R. (2001). A discrete density matrix theory for
atoms in strong magnetic fields. Communications in Mathematical Physics.
Springer. https://doi.org/10.1007/s002200100373
chicago: Hainzl, Christian, and Robert Seiringer. “A Discrete Density Matrix Theory
for Atoms in Strong Magnetic Fields.” Communications in Mathematical Physics.
Springer, 2001. https://doi.org/10.1007/s002200100373.
ieee: C. Hainzl and R. Seiringer, “A discrete density matrix theory for atoms in
strong magnetic fields,” Communications in Mathematical Physics, vol. 217,
no. 1. Springer, pp. 229–248, 2001.
ista: Hainzl C, Seiringer R. 2001. A discrete density matrix theory for atoms in
strong magnetic fields. Communications in Mathematical Physics. 217(1), 229–248.
mla: Hainzl, Christian, and Robert Seiringer. “A Discrete Density Matrix Theory
for Atoms in Strong Magnetic Fields.” Communications in Mathematical Physics,
vol. 217, no. 1, Springer, 2001, pp. 229–48, doi:10.1007/s002200100373.
short: C. Hainzl, R. Seiringer, Communications in Mathematical Physics 217 (2001)
229–248.
date_created: 2018-12-11T11:57:08Z
date_published: 2001-02-01T00:00:00Z
date_updated: 2023-05-30T06:54:54Z
day: '01'
doi: 10.1007/s002200100373
extern: '1'
external_id:
arxiv:
- math-ph/0010005
intvolume: ' 217'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math-ph/0010005
month: '02'
oa: 1
oa_version: Preprint
page: 229 - 248
publication: Communications in Mathematical Physics
publication_identifier:
issn:
- 0010-3616
publication_status: published
publisher: Springer
publist_id: '4578'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A discrete density matrix theory for atoms in strong magnetic fields
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 217
year: '2001'
...
---
_id: '2419'
abstract:
- lang: eng
text: For an absolutely continuous probability measure μ. on ℝd and a nonnegative
integer k, let S̃k(μ, 0) denote the probability that the convex hull of k + d
+ 1 random points which are i.i.d. according to μ contains the origin 0. For d
and k given, we determine a tight upper bound on S̃k(μ, 0), and we characterize
the measures in ℝd which attain this bound. As we will see, this result can be
considered a continuous analogue of the Upper Bound Theorem for the maximal number
of faces of convex polytopes with a given number of vertices. For our proof we
introduce so-called h-functions, continuous counterparts of h-vectors of simplicial
convex polytopes.
acknowledgement: We are indebted to Rolf Schneider for many helpful remarks and in
particular for bringing reference [6] to our attention
article_processing_charge: No
article_type: original
author:
- first_name: Uli
full_name: Wagner, Uli
id: 36690CA2-F248-11E8-B48F-1D18A9856A87
last_name: Wagner
orcid: 0000-0002-1494-0568
- first_name: Emo
full_name: Welzl, Emo
last_name: Welzl
citation:
ama: Wagner U, Welzl E. A continuous analogue of the Upper Bound Theorem. Discrete
& Computational Geometry. 2001;26(2):205-219. doi:10.1007/s00454-001-0028-9
apa: Wagner, U., & Welzl, E. (2001). A continuous analogue of the Upper Bound
Theorem. Discrete & Computational Geometry. Springer. https://doi.org/10.1007/s00454-001-0028-9
chicago: Wagner, Uli, and Emo Welzl. “A Continuous Analogue of the Upper Bound Theorem.”
Discrete & Computational Geometry. Springer, 2001. https://doi.org/10.1007/s00454-001-0028-9.
ieee: U. Wagner and E. Welzl, “A continuous analogue of the Upper Bound Theorem,”
Discrete & Computational Geometry, vol. 26, no. 2. Springer, pp. 205–219,
2001.
ista: Wagner U, Welzl E. 2001. A continuous analogue of the Upper Bound Theorem.
Discrete & Computational Geometry. 26(2), 205–219.
mla: Wagner, Uli, and Emo Welzl. “A Continuous Analogue of the Upper Bound Theorem.”
Discrete & Computational Geometry, vol. 26, no. 2, Springer, 2001,
pp. 205–19, doi:10.1007/s00454-001-0028-9.
short: U. Wagner, E. Welzl, Discrete & Computational Geometry 26 (2001) 205–219.
date_created: 2018-12-11T11:57:33Z
date_published: 2001-01-01T00:00:00Z
date_updated: 2023-05-24T13:13:51Z
day: '01'
doi: 10.1007/s00454-001-0028-9
extern: '1'
intvolume: ' 26'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 205 - 219
publication: Discrete & Computational Geometry
publication_identifier:
issn:
- 0179-5376
publication_status: published
publisher: Springer
publist_id: '4506'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A continuous analogue of the Upper Bound Theorem
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 26
year: '2001'
...
---
_id: '2604'
abstract:
- lang: eng
text: Cutaneous antidromic vasodilatation and plasma extravasation, two phenomena
that occur in neurogenic inflammation, are partially blocked by substance P (SP)
receptor antagonists and are known to be mediated in part by mast cell-released
substances, such as histamine, serotonin, and nitric oxide. In an attempt to provide
a morphological substrate for the above phenomena, we applied light and electron
microscopic immunocytochemistry to investigate the pattern of SP innervation of
blood vessels and its relationship to mast cells in the skin of the rat lower
lip. Furthermore, we examined the distribution of SP (neurokinin-1) receptors
and their relationship to SP-immunoreactive (IR) fibers. Our results confirmed
that SP-IR fibers are found in cutaneous nerves and that terminal branches are
observed around blood vessels and penetrating the epidermis. SP-IR fibers also
innervated hair follicles and sebaceous glands. At the ultrastructural level,
SP-IR varicosities were observed adjacent to arterioles, capillaries, venules,
and mast cells. The varicosities possessed both dense core vesicles and agranular
synaptic vesicles. We quantified the distance between SP-IR varicosities and blood
vessel endothelial cells. SP-IR terminals were located within 0.23-5.99 μm from
the endothelial cell layer in 82.7% of arterioles, in 90.2% of capillaries, and
in 86.9% of venules. Although there was a trend for SP-IR fibers to be located
closer to the endothelium of venules, this difference was not significant. Neurokinin-1
receptor (NK-1r) immunoreactivity was most abundant in the upper dermis and was
associated with the wall of blood vessels. NK-1r were located in equal amounts
on the walls of arterioles, capillaries, and venules that were innervated by SP-IR
fibers. The present results favor the concept of a participation of SP in cutaneous
neurogenic vasodilatation and plasma extravasation both by an action on blood
vessels after binding to the NK-1r and by causing the release of substances from
mast cells after diffusion through the connective tissue.
acknowledgement: This work was sponsored by grant MT-12170 from the Canadian Medical
Research Council. The authors thank Marie Ballak for electron microscopy assistance,
Alan Forster for photographic expertise, and Sid Parkinson for editorial
assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Isabella
full_name: Ruocco, Isabella
last_name: Ruocco
- first_name: Augusto
full_name: Cuello, Augusto
last_name: Cuello
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Alfredo
full_name: Ribeiro Da Silva, Alfredo
last_name: Ribeiro Da Silva
citation:
ama: Ruocco I, Cuello A, Shigemoto R, Ribeiro Da Silva A. Light and electron microscopic
study of the distribution of substance P-immunoreactive fibers and neurokinin-1
receptors in the skin of the rat lower lip. Journal of Comparative Neurology.
2001;432(4):466-480. doi:10.1002/cne.1114
apa: Ruocco, I., Cuello, A., Shigemoto, R., & Ribeiro Da Silva, A. (2001). Light
and electron microscopic study of the distribution of substance P-immunoreactive
fibers and neurokinin-1 receptors in the skin of the rat lower lip. Journal
of Comparative Neurology. Wiley-Blackwell. https://doi.org/10.1002/cne.1114
chicago: Ruocco, Isabella, Augusto Cuello, Ryuichi Shigemoto, and Alfredo Ribeiro
Da Silva. “Light and Electron Microscopic Study of the Distribution of Substance
P-Immunoreactive Fibers and Neurokinin-1 Receptors in the Skin of the Rat Lower
Lip.” Journal of Comparative Neurology. Wiley-Blackwell, 2001. https://doi.org/10.1002/cne.1114.
ieee: I. Ruocco, A. Cuello, R. Shigemoto, and A. Ribeiro Da Silva, “Light and electron
microscopic study of the distribution of substance P-immunoreactive fibers and
neurokinin-1 receptors in the skin of the rat lower lip,” Journal of Comparative
Neurology, vol. 432, no. 4. Wiley-Blackwell, pp. 466–480, 2001.
ista: Ruocco I, Cuello A, Shigemoto R, Ribeiro Da Silva A. 2001. Light and electron
microscopic study of the distribution of substance P-immunoreactive fibers and
neurokinin-1 receptors in the skin of the rat lower lip. Journal of Comparative
Neurology. 432(4), 466–480.
mla: Ruocco, Isabella, et al. “Light and Electron Microscopic Study of the Distribution
of Substance P-Immunoreactive Fibers and Neurokinin-1 Receptors in the Skin of
the Rat Lower Lip.” Journal of Comparative Neurology, vol. 432, no. 4,
Wiley-Blackwell, 2001, pp. 466–80, doi:10.1002/cne.1114.
short: I. Ruocco, A. Cuello, R. Shigemoto, A. Ribeiro Da Silva, Journal of Comparative
Neurology 432 (2001) 466–480.
date_created: 2018-12-11T11:58:37Z
date_published: 2001-04-16T00:00:00Z
date_updated: 2023-05-24T13:03:51Z
day: '16'
doi: 10.1002/cne.1114
extern: '1'
external_id:
pmid:
- '11268009'
intvolume: ' 432'
issue: '4'
language:
- iso: eng
month: '04'
oa_version: None
page: 466 - 480
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4294'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Light and electron microscopic study of the distribution of substance P-immunoreactive
fibers and neurokinin-1 receptors in the skin of the rat lower lip
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 432
year: '2001'
...
---
_id: '2605'
abstract:
- lang: eng
text: 'The granular layer of the cerebellar cortex consists of densely packed neuronal
cells, classified into granule cells and large interneurons. In this study, we
provide a comparative survey of large granular layer interneurons in the adult
rat cerebellum based on both morphological and neurochemical criteria. To this
end, double immunofluorescence histochemistry was performed by combining antibodies
against the cytoplasmic antigen Rat-303, calretinin, the metabotropic glutamate
receptor mGluR2 and somatostatin. Based on Rat-303/calretinin double immunohistochemistry,
three distinct populations of large granular layer interneurons could be discerned:
cells immunopositive for Rat-303, calretinin or both. Rat-303 or calretinin single-labeled
cells represented Golgi cells and unipolar brush cells, respectively. Rat-303/calretinin
double-labeled cells located just underneath the Purkinje cell layer represented
Lugaro cells. Morphometrical analysis distinguished two populations of Rat-303-positive
Golgi cells according to their location: vermis versus hemisphere. Immunostaining
for the metabotropic glutamate receptor mGluR2 combined with Rat-303 or calretinin
revealed that the majority of Golgi cells (about 90%) appeared to be mGluR2 positive.
Lugaro cells were mGluR2 negative. In addition, a limited population of large
polymorphous interneurons in the depth of the granular layer with morphological
features resembling Golgi cells also displayed Rat-303/calretinin immunoreactivity
and were mGluR2 negative. Double immunohistochemistry for Rat-303 and somatostatin
revealed three populations of labeled cells in the depth of the granular layer.
Besides double-labeled Golgi cells, Rat-303 or somatostatin single-labeled cells
were present. Based on mGluR2/somatostatin and calretinin/somatostatin double
immunostainings, Rat-303 single-labeled cells were found to correspond to Rat-303/calretinin-positive,
mGluR2-negative Golgi-like cells, while the identity of somatostatin single-labeled
cells remained unclear. The data presented in this article elaborate previous
reports on the morphological and neurochemical differentiation of large interneurons
in the rat cerebellar granular layer. In addition, they indicate that the current
classification of these cells into Golgi cells, Lugaro cells and unipolar brush
cells does not describe the observed neurochemical heterogeneity.'
article_processing_charge: No
article_type: original
author:
- first_name: Frederik
full_name: Geurts, Frederik
last_name: Geurts
- first_name: Jean
full_name: Timmermans, Jean
last_name: Timmermans
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Erik
full_name: De Schutter, Erik
last_name: De Schutter
citation:
ama: Geurts F, Timmermans J, Shigemoto R, De Schutter E. Morphological and neurochemical
differentiation of large granular layer interneurons in the adult rat cerebellum.
Neuroscience. 2001;104(2):499-512. doi:10.1016/S0306-4522(01)00058-6
apa: Geurts, F., Timmermans, J., Shigemoto, R., & De Schutter, E. (2001). Morphological
and neurochemical differentiation of large granular layer interneurons in the
adult rat cerebellum. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(01)00058-6
chicago: Geurts, Frederik, Jean Timmermans, Ryuichi Shigemoto, and Erik De Schutter.
“Morphological and Neurochemical Differentiation of Large Granular Layer Interneurons
in the Adult Rat Cerebellum.” Neuroscience. Elsevier, 2001. https://doi.org/10.1016/S0306-4522(01)00058-6.
ieee: F. Geurts, J. Timmermans, R. Shigemoto, and E. De Schutter, “Morphological
and neurochemical differentiation of large granular layer interneurons in the
adult rat cerebellum,” Neuroscience, vol. 104, no. 2. Elsevier, pp. 499–512,
2001.
ista: Geurts F, Timmermans J, Shigemoto R, De Schutter E. 2001. Morphological and
neurochemical differentiation of large granular layer interneurons in the adult
rat cerebellum. Neuroscience. 104(2), 499–512.
mla: Geurts, Frederik, et al. “Morphological and Neurochemical Differentiation of
Large Granular Layer Interneurons in the Adult Rat Cerebellum.” Neuroscience,
vol. 104, no. 2, Elsevier, 2001, pp. 499–512, doi:10.1016/S0306-4522(01)00058-6.
short: F. Geurts, J. Timmermans, R. Shigemoto, E. De Schutter, Neuroscience 104
(2001) 499–512.
date_created: 2018-12-11T11:58:38Z
date_published: 2001-05-10T00:00:00Z
date_updated: 2023-05-24T12:45:30Z
day: '10'
doi: 10.1016/S0306-4522(01)00058-6
extern: '1'
external_id:
pmid:
- '11377850'
intvolume: ' 104'
issue: '2'
language:
- iso: eng
month: '05'
oa_version: None
page: 499 - 512
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '4292'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Morphological and neurochemical differentiation of large granular layer interneurons
in the adult rat cerebellum
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 104
year: '2001'
...
---
_id: '2606'
abstract:
- lang: eng
text: Glutamate receptors have been linked to the regulation of several developmental
events in the CNS. By using cortical slices of early postnatal mice, we show that
in layer I cells, glutamate produces intracellular calcium ([Ca2+]i) elevations
mediated by ionotropic and metabotropic glutamate receptors (mGluRs). The contribution
of mGluRs to these responses was demonstrated by application of tACPD, an agonist
to groups I and II mGluRs, which evoked [Ca2+]i increases that could be reversibly
blocked by MCPG, an antagonist to groups I and II mGluRs. In the absence of extracellular
Ca2+, repetitive applications of tACPD or quisqualate, an agonist to group I mGluRs,
elicited decreasing [Ca2+]i responses that were restored by refilling a thapsigargin-sensitive
Ca2+ store. The use of specific group I mGluR agonists CHPG and DHPG indicated
that the functional mGluR in layer I was of the mGluR1 subtype. Subtype specific
antibodies confirmed the presence of mGlur1α, but not mGluR5, in Cajal-Retzius
(Reelin-immunoreactive) neurons.
acknowledgement: MV and AF are senior coauthors of this work, which was supported by
Ministerio de Educacion y Cultura, grants SAF97/0195 and SAF 2000-0152-C02-02 to
M.V; PB94-0219-CO2-01 and PB97-0582-CO2-01 to A.F., Accio Especial de R+D AE98-18 from Generalitat Valenciana, and a Fellowship
from Bancaixa-C.S.I.C. to J.R.M.-G. We wish to thank Andre M. Goffinet for his G10 antireelin antibody and Roberto Gallego, Juan M. Luque and Felix
Viana for their constructive criticisms on previous versions of the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Galán
full_name: Martínez, Galán
last_name: Martínez
- first_name: Guillermina
full_name: López Bendito, Guillermina
last_name: López Bendito
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Alfonso
full_name: Fairén, Alfonso
last_name: Fairén
- first_name: Miguel
full_name: Valdeolmillos, Miguel
last_name: Valdeolmillos
citation:
ama: Martínez G, López Bendito G, Luján R, Shigemoto R, Fairén A, Valdeolmillos
M. Cajal-Retzius cells in early postnatal mouse cortex selectively express functional
metabotropic glutamate receptors. European Journal of Neuroscience. 2001;13(6):1147-1154.
doi:10.1046/j.0953-816X.2001.01494.x
apa: Martínez, G., López Bendito, G., Luján, R., Shigemoto, R., Fairén, A., &
Valdeolmillos, M. (2001). Cajal-Retzius cells in early postnatal mouse cortex
selectively express functional metabotropic glutamate receptors. European Journal
of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.0953-816X.2001.01494.x
chicago: Martínez, Galán, Guillermina López Bendito, Rafael Luján, Ryuichi Shigemoto,
Alfonso Fairén, and Miguel Valdeolmillos. “Cajal-Retzius Cells in Early Postnatal
Mouse Cortex Selectively Express Functional Metabotropic Glutamate Receptors.”
European Journal of Neuroscience. Wiley-Blackwell, 2001. https://doi.org/10.1046/j.0953-816X.2001.01494.x.
ieee: G. Martínez, G. López Bendito, R. Luján, R. Shigemoto, A. Fairén, and M. Valdeolmillos,
“Cajal-Retzius cells in early postnatal mouse cortex selectively express functional
metabotropic glutamate receptors,” European Journal of Neuroscience, vol.
13, no. 6. Wiley-Blackwell, pp. 1147–1154, 2001.
ista: Martínez G, López Bendito G, Luján R, Shigemoto R, Fairén A, Valdeolmillos
M. 2001. Cajal-Retzius cells in early postnatal mouse cortex selectively express
functional metabotropic glutamate receptors. European Journal of Neuroscience.
13(6), 1147–1154.
mla: Martínez, Galán, et al. “Cajal-Retzius Cells in Early Postnatal Mouse Cortex
Selectively Express Functional Metabotropic Glutamate Receptors.” European
Journal of Neuroscience, vol. 13, no. 6, Wiley-Blackwell, 2001, pp. 1147–54,
doi:10.1046/j.0953-816X.2001.01494.x.
short: G. Martínez, G. López Bendito, R. Luján, R. Shigemoto, A. Fairén, M. Valdeolmillos,
European Journal of Neuroscience 13 (2001) 1147–1154.
date_created: 2018-12-11T11:58:38Z
date_published: 2001-03-01T00:00:00Z
date_updated: 2023-05-24T12:53:46Z
day: '01'
doi: 10.1046/j.0953-816X.2001.01494.x
extern: '1'
external_id:
pmid:
- '11285012'
intvolume: ' 13'
issue: '6'
language:
- iso: eng
month: '03'
oa_version: None
page: 1147 - 1154
pmid: 1
publication: European Journal of Neuroscience
publication_identifier:
issn:
- 0953-816X
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4293'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cajal-Retzius cells in early postnatal mouse cortex selectively express functional
metabotropic glutamate receptors
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 13
year: '2001'
...
---
_id: '2607'
abstract:
- lang: eng
text: Alternative splicing in the mGluR5 gene generates two different receptor isoforms,
of which expression is developmentally regulated. However, little is known about
the functional significance of mGluR5 splice variants. We have examined the functional
coupling, subcellular targeting, and effect on neuronal differentiation of epitope-tagged
mGluR5 isoforms by expression in neuroblastoma NG108-15 cells. We found that both
mGluR5 splice variants give rise to comparable [Ca2+]i transients and have similar
pharmacological profile. Tagged receptors were shown by immunofluorescence to
be inserted in the plasma membrane. In undifferentiated cells the subcellular
localization of the two mGluR5 isoforms was partially segregated, whereas in differentiated
cells the labeling largely redistributed to the newly formed neurites. Interestingly,
we demonstrate that mGluR5 splice variants dramatically influence the formation
and maturation of neurites; mGluR5a hinders the acquisition of mature neuronal
traits and mGluR5b fosters the elaboration and extension of neurites. These effects
are partly inhibited by MPEP.
acknowledgement: "The authors thank: Dr. J. M. Rimland and M. T. Scupoli for their
technical help with X. oocytes recordings and FAC sorting, respectively; Dr. Y.
Dalezios for helping with the statistical analyses; and Dr. G. Varani for helping
with the analyses of mRNA and genomic sequences. We are also grateful to Professor
F. Benfenati, Dr. F. Conquet, Dr. Rafael Lujan, Dr. J. McIlhinney, Professor P.
Somogyi, Dr. J. H. Xuereb, and Dr. M. Zoli for careful reading of the manuscript\r\nand
helpful suggestions. R.S. is supported by the Laboratory of Cerebral Structure,
National Institute for Physiological Sciences, Myodaiji, Okazaki 444-8585, CREST
Japan Science and Technology Corporation, Japan."
article_processing_charge: No
article_type: original
author:
- first_name: Silvia
full_name: Mion, Silvia
last_name: Mion
- first_name: Corrado
full_name: Corti, Corrado
last_name: Corti
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Mauro
full_name: Corsi, Mauro
last_name: Corsi
- first_name: Guido
full_name: Fumagalli, Guido
last_name: Fumagalli
- first_name: Francesco
full_name: Ferraguti, Francesco
last_name: Ferraguti
citation:
ama: Mion S, Corti C, Neki A, et al. Bidirectional regulation of neurite elaboration
by alternatively spliced metabotropic glutamate receptor 5 (mGluR5) isoforms.
Molecular and Cellular Neuroscience. 2001;17(6):957-972. doi:10.1006/mcne.2001.0993
apa: Mion, S., Corti, C., Neki, A., Shigemoto, R., Corsi, M., Fumagalli, G., &
Ferraguti, F. (2001). Bidirectional regulation of neurite elaboration by alternatively
spliced metabotropic glutamate receptor 5 (mGluR5) isoforms. Molecular and
Cellular Neuroscience. Academic Press. https://doi.org/10.1006/mcne.2001.0993
chicago: Mion, Silvia, Corrado Corti, Akio Neki, Ryuichi Shigemoto, Mauro Corsi,
Guido Fumagalli, and Francesco Ferraguti. “Bidirectional Regulation of Neurite
Elaboration by Alternatively Spliced Metabotropic Glutamate Receptor 5 (MGluR5)
Isoforms.” Molecular and Cellular Neuroscience. Academic Press, 2001. https://doi.org/10.1006/mcne.2001.0993.
ieee: S. Mion et al., “Bidirectional regulation of neurite elaboration by
alternatively spliced metabotropic glutamate receptor 5 (mGluR5) isoforms,” Molecular
and Cellular Neuroscience, vol. 17, no. 6. Academic Press, pp. 957–972, 2001.
ista: Mion S, Corti C, Neki A, Shigemoto R, Corsi M, Fumagalli G, Ferraguti F. 2001.
Bidirectional regulation of neurite elaboration by alternatively spliced metabotropic
glutamate receptor 5 (mGluR5) isoforms. Molecular and Cellular Neuroscience. 17(6),
957–972.
mla: Mion, Silvia, et al. “Bidirectional Regulation of Neurite Elaboration by Alternatively
Spliced Metabotropic Glutamate Receptor 5 (MGluR5) Isoforms.” Molecular and
Cellular Neuroscience, vol. 17, no. 6, Academic Press, 2001, pp. 957–72, doi:10.1006/mcne.2001.0993.
short: S. Mion, C. Corti, A. Neki, R. Shigemoto, M. Corsi, G. Fumagalli, F. Ferraguti,
Molecular and Cellular Neuroscience 17 (2001) 957–972.
date_created: 2018-12-11T11:58:38Z
date_published: 2001-06-01T00:00:00Z
date_updated: 2023-05-24T09:34:13Z
day: '01'
doi: 10.1006/mcne.2001.0993
extern: '1'
external_id:
pmid:
- '11414786'
intvolume: ' 17'
issue: '6'
language:
- iso: eng
month: '06'
oa_version: None
page: 957 - 972
pmid: 1
publication: Molecular and Cellular Neuroscience
publication_identifier:
issn:
- 1044-7431
publication_status: published
publisher: Academic Press
publist_id: '4291'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Bidirectional regulation of neurite elaboration by alternatively spliced metabotropic
glutamate receptor 5 (mGluR5) isoforms
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '2001'
...
---
_id: '2608'
abstract:
- lang: eng
text: The regulation of neurotransmitter receptors during synapse formation has
been studied extensively at the neuromuscular junction, but little is known about
the development of excitatory neurotransmitter receptors during synaptogenesis
in central synapses. In this study we show qualitatively and quantitatively that
a receptor undergoes changes in localisation on the surface of rat Purkinje cells
during development in association with its excitatory synapses. The presence of
mGluR1α at parallel and climbing fibre synapses on developing Purkinje cells was
studied using high-resolution immunoelectron microscopy. Immunoreactivity for
mGluR1α was detected from embryonic day 18 in Purkinje cells, and showed dramatic
changes in its localisation with age. At early postnatal ages (P0 and P3), mGluR1α
was found both in somata and stem dendrites but was not usually associated with
synaptic contacts. At P7, mGluR1α became concentrated in somatic spines associated
with climbing fibres and in the growing dendritic arborisation even before innervation
by parallel fibres. During the second and third postnatal week, when spines and
parallel fibre synapses were generated, mGluR1α became progressively concentrated
in the molecular layer, particularly in the synaptic specialisations. As a result,
during the fourth postnatal week, the pattern and level of mGluR1α expression
became similar to the adult and mGluR1α appeared in high density in perisynaptic
sites. Our results indicate that mGluR1α is present in the developing Purkinje
cells prior to their innervation by climbing and parallel fibres and demonstrate
that this receptor undergoes a dynamic and specific regulation during postnatal
development in association with the establishment of synaptic inputs to Purkinje
cell.
acknowledgement: öWe thank Drs. Paul Bolam, Ole Paulsen, Je¡ McIlhinney, Alfonso Faire¨n
and Francisco Ciruela for reviewing a previous version of this manuscript and Mrs
Alexandra Salewski for the English revision of the manuscript. We also want to thank
Dr. Peter Somogyi for offering the facilities of the MRC Anatomical Neuropharmacology
Unit to carry out part of this study. This work was supported by a Grant from the
European Community (QLG3-CT-1999-00192 to R.L.) and the Spanish Ministry of Education
(DGES PM 97-0082 to J.M.J.).
article_processing_charge: No
article_type: original
author:
- first_name: Guillermina
full_name: López Bendito, Guillermina
last_name: López Bendito
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
- first_name: José
full_name: Juíz, José
last_name: Juíz
citation:
ama: López Bendito G, Shigemoto R, Luján R, Juíz J. Developmental changes in the
localisation of the mGluR1α subtype of metabotropic glutamate receptors in Purkinje
cells. Neuroscience. 2001;105(2):413-429. doi:10.1016/S0306-4522(01)00188-9
apa: López Bendito, G., Shigemoto, R., Luján, R., & Juíz, J. (2001). Developmental
changes in the localisation of the mGluR1α subtype of metabotropic glutamate receptors
in Purkinje cells. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(01)00188-9
chicago: López Bendito, Guillermina, Ryuichi Shigemoto, Rafael Luján, and José Juíz.
“Developmental Changes in the Localisation of the MGluR1α Subtype of Metabotropic
Glutamate Receptors in Purkinje Cells.” Neuroscience. Elsevier, 2001. https://doi.org/10.1016/S0306-4522(01)00188-9.
ieee: G. López Bendito, R. Shigemoto, R. Luján, and J. Juíz, “Developmental changes
in the localisation of the mGluR1α subtype of metabotropic glutamate receptors
in Purkinje cells,” Neuroscience, vol. 105, no. 2. Elsevier, pp. 413–429,
2001.
ista: López Bendito G, Shigemoto R, Luján R, Juíz J. 2001. Developmental changes
in the localisation of the mGluR1α subtype of metabotropic glutamate receptors
in Purkinje cells. Neuroscience. 105(2), 413–429.
mla: López Bendito, Guillermina, et al. “Developmental Changes in the Localisation
of the MGluR1α Subtype of Metabotropic Glutamate Receptors in Purkinje Cells.”
Neuroscience, vol. 105, no. 2, Elsevier, 2001, pp. 413–29, doi:10.1016/S0306-4522(01)00188-9.
short: G. López Bendito, R. Shigemoto, R. Luján, J. Juíz, Neuroscience 105 (2001)
413–429.
date_created: 2018-12-11T11:58:39Z
date_published: 2001-07-27T00:00:00Z
date_updated: 2023-05-24T09:31:48Z
day: '27'
doi: 10.1016/S0306-4522(01)00188-9
extern: '1'
external_id:
pmid:
- '11672608 '
intvolume: ' 105'
issue: '2'
language:
- iso: eng
month: '07'
oa_version: None
page: 413 - 429
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '4290'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Developmental changes in the localisation of the mGluR1α subtype of metabotropic
glutamate receptors in Purkinje cells
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 105
year: '2001'
...
---
_id: '2609'
abstract:
- lang: eng
text: 'The metabotropic glutamate receptors (mGluRs) have distinct distribution
patterns in the CNS but subtypes within group I or group III mGluRs share similar
ultrastructural localization relative to neurotransmitter release sites: group
I mGluRs are concentrated in an annulus surrounding the edge of the postsynaptic
density, whereas group III mGluRs are concentrated in the presynaptic active zone.
One of the group II subtypes, mGluR2, is expressed in both pre- and postsynaptic
elements, having no close association with synapses. In order to determine if
such a distribution is common to another group II subtype, mGluR3, an antibody
was raised against a carboxy-terminus of mGluR3 and used for light and electron
microscopic immunohistochemistry in the mouse CNS. The antibody reacted strongly
with mGluR3, but it also reacted, though only weakly, with mGluR2. Therefore,
to examine mGluR3-selective distribution, we used mGluR2-deficient mice as well
as wild-type mice. Strong immunoreactivity for mGluR3 was found in the cerebral
cortex, striatum, dentate gyrus of the hippocampus, olfactory tubercle, lateral
septal nucleus, lateral and basolateral amygdaloid nuclei, and nucleus of the
lateral olfactory tract. Pre-embedding immunoperoxidase and immunogold methods
revealed mGluR3 labeling in both presynaptic and postsynaptic elements, and also
in glial profiles. Double labeling revealed that the vast majority of mGluR3 in
presynaptic elements is not closely associated with glutamate and GABA release
sites in the striatum and thalamus, respectively. However, in the spines of the
dentate granule cells, the highest receptor density was found in perisynaptic
sites (20% of immunogold particles within 60 nm from the edge of postsynaptic
membrane specialization) followed by a decreasing receptor density away from the
synapses (to ∼5% of particles per 60 nm). Furthermore, 19% of immunogold particles
were located in asymmetrical postsynaptic specialization, indicating an association
of mGluR3 to glutamatergic synapses. The present results indicate that the localization
of mGluR3 is rather similar to that of group I mGluRs in the postsynaptic elements,
suggesting a unique functional role of mGluR3 in glutamatergic neurotransmission
in the CNS.'
acknowledgement: We are grateful to M. Yokoi and S. Nakanishi for kindly providing
us with the mGluR2-de¢cient mice and F. Ferraguti for mGluR8b cDNA. The technical
assistance of S. Doi and the photographic assistance of A. Uesugi are acknowledged.
This work has been supported by research grants from the Ministry of Education,
Sports, Culture, Science, and Technology of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: Y
full_name: Tamaru, Y
last_name: Tamaru
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: 'Tamaru Y, Nomura S, Mizuno N, Shigemoto R. Distribution of metabotropic glutamate
receptor mGluR3 in the mouse CNS: Differential location relative to pre- and postsynaptic
sites. Neuroscience. 2001;106(3):481-503. doi:10.1016/S0306-4522(01)00305-0'
apa: 'Tamaru, Y., Nomura, S., Mizuno, N., & Shigemoto, R. (2001). Distribution
of metabotropic glutamate receptor mGluR3 in the mouse CNS: Differential location
relative to pre- and postsynaptic sites. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(01)00305-0'
chicago: 'Tamaru, Y, Sakashi Nomura, Noboru Mizuno, and Ryuichi Shigemoto. “Distribution
of Metabotropic Glutamate Receptor MGluR3 in the Mouse CNS: Differential Location
Relative to Pre- and Postsynaptic Sites.” Neuroscience. Elsevier, 2001.
https://doi.org/10.1016/S0306-4522(01)00305-0.'
ieee: 'Y. Tamaru, S. Nomura, N. Mizuno, and R. Shigemoto, “Distribution of metabotropic
glutamate receptor mGluR3 in the mouse CNS: Differential location relative to
pre- and postsynaptic sites,” Neuroscience, vol. 106, no. 3. Elsevier,
pp. 481–503, 2001.'
ista: 'Tamaru Y, Nomura S, Mizuno N, Shigemoto R. 2001. Distribution of metabotropic
glutamate receptor mGluR3 in the mouse CNS: Differential location relative to
pre- and postsynaptic sites. Neuroscience. 106(3), 481–503.'
mla: 'Tamaru, Y., et al. “Distribution of Metabotropic Glutamate Receptor MGluR3
in the Mouse CNS: Differential Location Relative to Pre- and Postsynaptic Sites.”
Neuroscience, vol. 106, no. 3, Elsevier, 2001, pp. 481–503, doi:10.1016/S0306-4522(01)00305-0.'
short: Y. Tamaru, S. Nomura, N. Mizuno, R. Shigemoto, Neuroscience 106 (2001) 481–503.
date_created: 2018-12-11T11:58:39Z
date_published: 2001-09-27T00:00:00Z
date_updated: 2023-05-24T08:51:17Z
day: '27'
doi: 10.1016/S0306-4522(01)00305-0
extern: '1'
external_id:
pmid:
- '11591452'
intvolume: ' 106'
issue: '3'
language:
- iso: eng
month: '09'
oa_version: None
page: 481 - 503
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '4289'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: Differential
location relative to pre- and postsynaptic sites'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 106
year: '2001'
...
---
_id: '2610'
abstract:
- lang: eng
text: To study the role of mGlu7 receptors (mGluR7), we used homologous recombination
to generate mice lacking this metabotropic receptor subtype (mGluR7 -/-). After
the serendipitous discovery of a sensory stimulus-evoked epileptic phenotype,
we tested two convulsant drugs, pentylenetetrazole (PTZ) and bicuculline. In animals
aged 12 weeks and older, subthreshold doses of these drugs induced seizures in
mGluR7 -/-, but not in mGluR7 +/-, mice. PTZ-induced seizures were inhibited by
three standard anticonvulsant drugs, but not by the group III selective mGluR
agonist (R,S)-4-phosphonophenylglycine (PPG). Consistent with the lack of signs
of epileptic activity in the absence of specific stimuli, mGluR7 -/- mice showed
no major changes in synaptic properties in two slice preparations. However, slightly
increased excitability was evident in hippocampal slices. In addition, there was
slower recovery from frequency facilitation in cortical slices, suggesting a role
for mGluR7 as a frequency-dependent regulator in presynaptic terminals. Our findings
suggest that mGluR7 receptors have a unique role in regulating neuronal excitability
and that these receptors may be a novel target for the development of anticonvulsant
drugs.
acknowledgement: This work was supported in part by the Biotechnology and Biological
Sciences Research Council and Medical Research Council (UK). We thank Doris Ruegg
for sequencing, Gemma Texido and Klaus Rajewsky for pTV-0 DNA, J.-F. Pin for mGluR8
cDNA, K. von Figura for E14 ES cells, Pedro Grandes for histological examination
of brain sections, Christoph Wiessner for help with plots and statistics, Valerie
Schuler for help with Western blots, and the team of the Novartis special strain
breeding facility for their support.
article_processing_charge: No
article_type: original
author:
- first_name: Gilles
full_name: Sansig, Gilles
last_name: Sansig
- first_name: Trevor
full_name: Bushell, Trevor
last_name: Bushell
- first_name: Vernon
full_name: Clarke, Vernon
last_name: Clarke
- first_name: Andrei
full_name: Rozov, Andrei
last_name: Rozov
- first_name: Nail
full_name: Burnashev, Nail
last_name: Burnashev
- first_name: Chantal
full_name: Portet, Chantal
last_name: Portet
- first_name: Fabrizio
full_name: Gasparini, Fabrizio
last_name: Gasparini
- first_name: Markus
full_name: Schmutz, Markus
last_name: Schmutz
- first_name: Klaus
full_name: Klebs, Klaus
last_name: Klebs
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Peter
full_name: Flor, Peter
last_name: Flor
- first_name: Rainer
full_name: Kühn, Rainer
last_name: Kühn
- first_name: Thomas
full_name: Knoepfel, Thomas
last_name: Knoepfel
- first_name: Markus
full_name: Schroeder, Markus
last_name: Schroeder
- first_name: David
full_name: Hampson, David
last_name: Hampson
- first_name: Valerie
full_name: Collett, Valerie
last_name: Collett
- first_name: Congxiao
full_name: Zhang, Congxiao
last_name: Zhang
- first_name: Robert
full_name: Duvoisin, Robert
last_name: Duvoisin
- first_name: Graham
full_name: Collingridge, Graham
last_name: Collingridge
- first_name: Herman
full_name: Van Der Putten, Herman
last_name: Van Der Putten
citation:
ama: Sansig G, Bushell T, Clarke V, et al. Increased seizure susceptibility in mice
lacking metabotropic glutamate receptor 7. Journal of Neuroscience. 2001;21(22):8734-8745.
doi:10.1523/JNEUROSCI.21-22-08734.2001
apa: Sansig, G., Bushell, T., Clarke, V., Rozov, A., Burnashev, N., Portet, C.,
… Van Der Putten, H. (2001). Increased seizure susceptibility in mice lacking
metabotropic glutamate receptor 7. Journal of Neuroscience. Society for
Neuroscience. https://doi.org/10.1523/JNEUROSCI.21-22-08734.2001
chicago: Sansig, Gilles, Trevor Bushell, Vernon Clarke, Andrei Rozov, Nail Burnashev,
Chantal Portet, Fabrizio Gasparini, et al. “Increased Seizure Susceptibility in
Mice Lacking Metabotropic Glutamate Receptor 7.” Journal of Neuroscience.
Society for Neuroscience, 2001. https://doi.org/10.1523/JNEUROSCI.21-22-08734.2001.
ieee: G. Sansig et al., “Increased seizure susceptibility in mice lacking
metabotropic glutamate receptor 7,” Journal of Neuroscience, vol. 21, no.
22. Society for Neuroscience, pp. 8734–8745, 2001.
ista: Sansig G, Bushell T, Clarke V, Rozov A, Burnashev N, Portet C, Gasparini F,
Schmutz M, Klebs K, Shigemoto R, Flor P, Kühn R, Knoepfel T, Schroeder M, Hampson
D, Collett V, Zhang C, Duvoisin R, Collingridge G, Van Der Putten H. 2001. Increased
seizure susceptibility in mice lacking metabotropic glutamate receptor 7. Journal
of Neuroscience. 21(22), 8734–8745.
mla: Sansig, Gilles, et al. “Increased Seizure Susceptibility in Mice Lacking Metabotropic
Glutamate Receptor 7.” Journal of Neuroscience, vol. 21, no. 22, Society
for Neuroscience, 2001, pp. 8734–45, doi:10.1523/JNEUROSCI.21-22-08734.2001.
short: G. Sansig, T. Bushell, V. Clarke, A. Rozov, N. Burnashev, C. Portet, F. Gasparini,
M. Schmutz, K. Klebs, R. Shigemoto, P. Flor, R. Kühn, T. Knoepfel, M. Schroeder,
D. Hampson, V. Collett, C. Zhang, R. Duvoisin, G. Collingridge, H. Van Der Putten,
Journal of Neuroscience 21 (2001) 8734–8745.
date_created: 2018-12-11T11:58:39Z
date_published: 2001-11-15T00:00:00Z
date_updated: 2023-05-24T08:47:53Z
day: '15'
doi: 10.1523/JNEUROSCI.21-22-08734.2001
extern: '1'
external_id:
pmid:
- '11698585'
intvolume: ' 21'
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6762269/
month: '11'
oa: 1
oa_version: Published Version
page: 8734 - 8745
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4288'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Increased seizure susceptibility in mice lacking metabotropic glutamate receptor
7
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 21
year: '2001'
...
---
_id: '2611'
abstract:
- lang: eng
text: Research using animal models of neuropathic pain has revealed sympathetic
sprouting onto dorsal root ganglion cells. More recently, sensory fibre sprouting
onto dorsal root ganglion cells has also been observed. Previous work in our laboratory
demonstrated persistent sympathetic fibre sprouting in the skin of the rat lower
lip following sensory denervation of this region. Therefore, we applied immunocytochemistry
to determine the effects of sympathectomies on the terminal fields of sensory
fibres. The superior cervical ganglia were removed bilaterally and the effects
on the innervation of the skin of the rat lower lip were observed 1, 2, 3, 4,
6 and 8 weeks post-surgery. Substance P and dopamine-β-hydroxylase immunoreactivities
were used to identify a subset of sensory and sympathetic fibres, respectively.
We also assessed neurokinin-1 receptor immunoreactivity. Quantitative data was
obtained with the aid of an image analysis system. In controls, the epidermis
and upper dermis were innervated by substance P-immunoreactive fibres only and
upper dermal blood vessels possessed the highest density of neurokinin-1 receptor
immunoreactivity. Blood vessels in the lower dermis were innervated by both substance
P- and dopamine-β-hydroxylase-immunoreactive fibres. Following sympathectomies,
substance P-immunoreactive fibres in the epidermis and upper dermis were more
intensely labelled only 1 and 2 weeks post-surgery when compared to sham controls.
The length of substance P-immunoreactive fibres in this region was also increased
only on the second week. Neurokinin-1 receptor immunoreactivity in the upper dermis
was slightly decreased 1 and 2 weeks post-surgery. In the lower dermis, substance
P-immunoreactive fibres associated with blood vessels were more intensely labelled
only 1 and 2 weeks post-surgery, and at all post-surgical time points studied,
blood vessels in this region were devoid of dopamine-β-hydroxylase-immunoreactive
fibres. The length of substance P-immunoreactive fibres was increased from the
first to the third week post-surgery in the lower dermis. These results indicate
that sympathectomies lead to transient changes in substance P-immunoreactive fibre
innervation and neurokinin-1 receptor expression in rat lower lip skin. The effects
are most prominent in the lower dermis probably due to a greater local concentration
of nerve growth factor in this region. The plasticity of the interactions between
sensory and sympathetic fibres may prove important in the regulation of skin microcirculation
and in the generation of painful sensations under normal conditions or following
peripheral nerve injuries.
acknowledgement: 'The work contained in this manuscript was sponsored by the Canadian
MRC, Grants # MT-12170 and MoP-38093. The authors would like to thank Sylvain Cote
for technical assistance and Sid Parkinson for editorial assistance.'
article_processing_charge: No
article_type: original
author:
- first_name: Isabella
full_name: Ruocco, Isabella
last_name: Ruocco
- first_name: Augusto
full_name: Cuello, Augusto
last_name: Cuello
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Alfredo
full_name: Ribeiro Da Silva, Alfredo
last_name: Ribeiro Da Silva
citation:
ama: Ruocco I, Cuello A, Shigemoto R, Ribeiro Da Silva A. Sympathectomies lead to
transient substance P-immunoreactive sensory fibre plasticity in the rat skin.
Neuroscience. 2001;108(1):157-166. doi:10.1016/S0306-4522(01)00158-0
apa: Ruocco, I., Cuello, A., Shigemoto, R., & Ribeiro Da Silva, A. (2001). Sympathectomies
lead to transient substance P-immunoreactive sensory fibre plasticity in the rat
skin. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(01)00158-0
chicago: Ruocco, Isabella, Augusto Cuello, Ryuichi Shigemoto, and Alfredo Ribeiro
Da Silva. “Sympathectomies Lead to Transient Substance P-Immunoreactive Sensory
Fibre Plasticity in the Rat Skin.” Neuroscience. Elsevier, 2001. https://doi.org/10.1016/S0306-4522(01)00158-0.
ieee: I. Ruocco, A. Cuello, R. Shigemoto, and A. Ribeiro Da Silva, “Sympathectomies
lead to transient substance P-immunoreactive sensory fibre plasticity in the rat
skin,” Neuroscience, vol. 108, no. 1. Elsevier, pp. 157–166, 2001.
ista: Ruocco I, Cuello A, Shigemoto R, Ribeiro Da Silva A. 2001. Sympathectomies
lead to transient substance P-immunoreactive sensory fibre plasticity in the rat
skin. Neuroscience. 108(1), 157–166.
mla: Ruocco, Isabella, et al. “Sympathectomies Lead to Transient Substance P-Immunoreactive
Sensory Fibre Plasticity in the Rat Skin.” Neuroscience, vol. 108, no.
1, Elsevier, 2001, pp. 157–66, doi:10.1016/S0306-4522(01)00158-0.
short: I. Ruocco, A. Cuello, R. Shigemoto, A. Ribeiro Da Silva, Neuroscience 108
(2001) 157–166.
date_created: 2018-12-11T11:58:40Z
date_published: 2001-12-05T00:00:00Z
date_updated: 2023-05-22T12:15:44Z
day: '05'
doi: 10.1016/S0306-4522(01)00158-0
extern: '1'
external_id:
pmid:
- '11738139'
intvolume: ' 108'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 157 - 166
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '4286'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sympathectomies lead to transient substance P-immunoreactive sensory fibre
plasticity in the rat skin
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 108
year: '2001'
...
---
_id: '2612'
abstract:
- lang: eng
text: 'We examined immunoreactivities for γ-aminobutyric acidB-receptor (GABABR)
subtypes, GABABR1 and GABABR2, in the mesencephalic trigeminal nucleus neurons
(MTN neurons) of the rat. Immunoreactivity for GABABR1 was prominent in cell bodies
of MTN, whereas that for GABABR2 was very weak, if existed. For electron microscopy,
the immunogold-silver method for GABABR1 was combined with the immunoperoxidase
method for glutamic acid decarboxylase (GAD: the synthetic enzyme of GABA). Immunogold-silver
particles indicating GABABR1 immunoreactivity were distributed widely in the cytoplasm
of the cell bodies postsynaptic to GAD-immunoreactive axon terminals, but were
rarely associated with synaptic membrane specialization or extrasynaptic sites
of plasma membrane. It has been indicated that GABABR1 may not be transported
to plasma membrane when no GABABR2 exists. Thus, it was presumed that GABABR1
in the cell body of the rat MTN neurons might not be involved in the synaptic
transmission.'
acknowledgement: This work was supported in part by Grants-in-Aid from the National
Natural Science Foundation of China (39870262, 39970239), from the Foundation for
University Key Teacher of the Ministry of Education of China, and from the Ministry
of Education, Science, Sports, Culture and Technology of Japan (12308039, 12680743).
article_processing_charge: No
article_type: original
author:
- first_name: Jin
full_name: Li, Jin
last_name: Li
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Ákos
full_name: Kulik, Ákos
last_name: Kulik
- first_name: Peng
full_name: Chen, Peng
last_name: Chen
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Li J, Shigemoto R, Kulik Á, et al. Immunocytochemical localization of GABAB
receptors in mesencephalic trigeminal nucleus neurons in the rat. Neuroscience
Letters. 2001;315(1-2):93-97. doi:10.1016/S0304-3940(01)02321-7
apa: Li, J., Shigemoto, R., Kulik, Á., Chen, P., Nomura, S., Kaneko, T., & Mizuno,
N. (2001). Immunocytochemical localization of GABAB receptors in mesencephalic
trigeminal nucleus neurons in the rat. Neuroscience Letters. Elsevier.
https://doi.org/10.1016/S0304-3940(01)02321-7
chicago: Li, Jin, Ryuichi Shigemoto, Ákos Kulik, Peng Chen, Sakashi Nomura, Takeshi
Kaneko, and Noboru Mizuno. “Immunocytochemical Localization of GABAB Receptors
in Mesencephalic Trigeminal Nucleus Neurons in the Rat.” Neuroscience Letters.
Elsevier, 2001. https://doi.org/10.1016/S0304-3940(01)02321-7.
ieee: J. Li et al., “Immunocytochemical localization of GABAB receptors in
mesencephalic trigeminal nucleus neurons in the rat,” Neuroscience Letters,
vol. 315, no. 1–2. Elsevier, pp. 93–97, 2001.
ista: Li J, Shigemoto R, Kulik Á, Chen P, Nomura S, Kaneko T, Mizuno N. 2001. Immunocytochemical
localization of GABAB receptors in mesencephalic trigeminal nucleus neurons in
the rat. Neuroscience Letters. 315(1–2), 93–97.
mla: Li, Jin, et al. “Immunocytochemical Localization of GABAB Receptors in Mesencephalic
Trigeminal Nucleus Neurons in the Rat.” Neuroscience Letters, vol. 315,
no. 1–2, Elsevier, 2001, pp. 93–97, doi:10.1016/S0304-3940(01)02321-7.
short: J. Li, R. Shigemoto, Á. Kulik, P. Chen, S. Nomura, T. Kaneko, N. Mizuno,
Neuroscience Letters 315 (2001) 93–97.
date_created: 2018-12-11T11:58:40Z
date_published: 2001-11-23T00:00:00Z
date_updated: 2023-05-22T12:30:05Z
day: '23'
doi: 10.1016/S0304-3940(01)02321-7
extern: '1'
external_id:
pmid:
- '11711223'
intvolume: ' 315'
issue: 1-2
language:
- iso: eng
month: '11'
oa_version: None
page: 93 - 97
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4287'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Immunocytochemical localization of GABAB receptors in mesencephalic trigeminal
nucleus neurons in the rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 315
year: '2001'
...
---
_id: '841'
article_processing_charge: No
article_type: original
author:
- first_name: Yuri
full_name: Wolf, Yuri
last_name: Wolf
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Eugene
full_name: Koonin, Eugene
last_name: Koonin
citation:
ama: 'Wolf Y, Kondrashov F, Koonin E. Footprints of primordial introns on the eukaryotic
genome: still no clear traces . Trends in Genetics. 2001;17(9):499-501.
doi:10.1016/S0168-9525(01)02376-9'
apa: 'Wolf, Y., Kondrashov, F., & Koonin, E. (2001). Footprints of primordial
introns on the eukaryotic genome: still no clear traces . Trends in Genetics.
Elsevier. https://doi.org/10.1016/S0168-9525(01)02376-9'
chicago: 'Wolf, Yuri, Fyodor Kondrashov, and Eugene Koonin. “Footprints of Primordial
Introns on the Eukaryotic Genome: Still No Clear Traces .” Trends in Genetics.
Elsevier, 2001. https://doi.org/10.1016/S0168-9525(01)02376-9.'
ieee: 'Y. Wolf, F. Kondrashov, and E. Koonin, “Footprints of primordial introns
on the eukaryotic genome: still no clear traces ,” Trends in Genetics,
vol. 17, no. 9. Elsevier, pp. 499–501, 2001.'
ista: 'Wolf Y, Kondrashov F, Koonin E. 2001. Footprints of primordial introns on
the eukaryotic genome: still no clear traces . Trends in Genetics. 17(9), 499–501.'
mla: 'Wolf, Yuri, et al. “Footprints of Primordial Introns on the Eukaryotic Genome:
Still No Clear Traces .” Trends in Genetics, vol. 17, no. 9, Elsevier,
2001, pp. 499–501, doi:10.1016/S0168-9525(01)02376-9.'
short: Y. Wolf, F. Kondrashov, E. Koonin, Trends in Genetics 17 (2001) 499–501.
date_created: 2018-12-11T11:48:47Z
date_published: 2001-09-01T00:00:00Z
date_updated: 2023-06-02T09:38:37Z
day: '01'
doi: 10.1016/S0168-9525(01)02376-9
extern: '1'
external_id:
pmid:
- '11721681'
intvolume: ' 17'
issue: '9'
language:
- iso: eng
month: '09'
oa_version: None
page: 499 - 501
pmid: 1
publication: Trends in Genetics
publication_identifier:
issn:
- 0168-9479
publication_status: published
publisher: Elsevier
publist_id: '6805'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Footprints of primordial introns on the eukaryotic genome: still no clear
traces '
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '2001'
...
---
_id: '851'
abstract:
- lang: eng
text: 'The study and comparison of mutation(al) spectra is an important problem
in molecular biology, because these spectra often reflect on important features
of mutations and their fixation. Such features include the interaction of DNA
with various mutagens, the function of repair/replication enzymes, and properties
of target proteins. It is known that mutability varies significantly along nucleotide
sequences, such that mutations often concentrate at certain positions, called
"hotspots," in a sequence. In this paper, we discuss in detail two approaches
for mutation spectra analysis: the comparison of mutation spectra with a HG-PUBL
program, (FTP: sunsite.unc.edu/pub/academic/ biology/dna-mutations/hyperg) and
hotspot prediction with the CLUSTERM program (www.itba.mi.cnr.it/webmutation;
ftp.bionet.nsc.ru/pub/biology/dbms/clusterm.zip). Several other approaches for
mutational spectra analysis, such as the analysis of a target protein structure,
hotspot context revealing, multiple spectra comparisons, as well as a number of
mutation databases are briefly described. Mutation spectra in the lacI gene of
E. coli and the human p53 gene are used for illustration of various difficulties
of such analysis.'
acknowledgement: 'Russian Fund of Fundamental Research. Grant Number: 99-04-49535.
NIH. Grant Number: GM 20293. NASA. Grant Number: NCC2-1057'
article_processing_charge: No
article_type: original
author:
- first_name: Igor
full_name: Rogozin, Igor
last_name: Rogozin
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Galina
full_name: Glazko, Galina
last_name: Glazko
citation:
ama: Rogozin I, Kondrashov F, Glazko G. Use of mutation spectra analysis software.
Human Mutation. 2001;17(2):83-102. doi:10.1002/1098-1004(200102)17:2<83::AID-HUMU1>3.0.CO;2-E
apa: Rogozin, I., Kondrashov, F., & Glazko, G. (2001). Use of mutation spectra
analysis software. Human Mutation. Wiley-Blackwell. https://doi.org/10.1002/1098-1004(200102)17:2<83::AID-HUMU1>3.0.CO;2-E
chicago: Rogozin, Igor, Fyodor Kondrashov, and Galina Glazko. “Use of Mutation Spectra
Analysis Software.” Human Mutation. Wiley-Blackwell, 2001. https://doi.org/10.1002/1098-1004(200102)17:2<83::AID-HUMU1>3.0.CO;2-E.
ieee: I. Rogozin, F. Kondrashov, and G. Glazko, “Use of mutation spectra analysis
software,” Human Mutation, vol. 17, no. 2. Wiley-Blackwell, pp. 83–102,
2001.
ista: Rogozin I, Kondrashov F, Glazko G. 2001. Use of mutation spectra analysis
software. Human Mutation. 17(2), 83–102.
mla: Rogozin, Igor, et al. “Use of Mutation Spectra Analysis Software.” Human
Mutation, vol. 17, no. 2, Wiley-Blackwell, 2001, pp. 83–102, doi:10.1002/1098-1004(200102)17:2<83::AID-HUMU1>3.0.CO;2-E.
short: I. Rogozin, F. Kondrashov, G. Glazko, Human Mutation 17 (2001) 83–102.
date_created: 2018-12-11T11:48:50Z
date_published: 2001-01-01T00:00:00Z
date_updated: 2023-06-02T09:22:17Z
day: '01'
doi: 10.1002/1098-1004(200102)17:2<83::AID-HUMU1>3.0.CO;2-E
extern: '1'
external_id:
pmid:
- '11180592'
intvolume: ' 17'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 83 - 102
pmid: 1
publication: Human Mutation
publication_identifier:
issn:
- 1059-7794
publication_status: published
publisher: Wiley-Blackwell
publist_id: '6796'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Use of mutation spectra analysis software
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '2001'
...
---
_id: '8521'
abstract:
- lang: eng
text: We continue the previous article's discussion of bounds, for prevalent diffeomorphisms
of smooth compact manifolds, on the growth of the number of periodic points and
the decay of their hyperbolicity as a function of their period $n$. In that article
we reduced the main results to a problem, for certain families of diffeomorphisms,
of bounding the measure of parameter values for which the diffeomorphism has (for
a given period $n$) an almost periodic point that is almost nonhyperbolic. We
also formulated our results for $1$-dimensional endomorphisms on a compact interval.
In this article we describe some of the main techniques involved and outline the
rest of the proof. To simplify notation, we concentrate primarily on the $1$-dimensional
case.
article_processing_charge: No
article_type: original
author:
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
- first_name: Brian R.
full_name: Hunt, Brian R.
last_name: Hunt
citation:
ama: Kaloshin V, Hunt BR. A stretched exponential bound on the rate of growth of
the number of periodic points for prevalent diffeomorphisms II. Electronic
Research Announcements of the American Mathematical Society. 2001;7(5):28-36.
doi:10.1090/s1079-6762-01-00091-9
apa: Kaloshin, V., & Hunt, B. R. (2001). A stretched exponential bound on the
rate of growth of the number of periodic points for prevalent diffeomorphisms
II. Electronic Research Announcements of the American Mathematical Society.
American Mathematical Society. https://doi.org/10.1090/s1079-6762-01-00091-9
chicago: Kaloshin, Vadim, and Brian R. Hunt. “A Stretched Exponential Bound on the
Rate of Growth of the Number of Periodic Points for Prevalent Diffeomorphisms
II.” Electronic Research Announcements of the American Mathematical Society.
American Mathematical Society, 2001. https://doi.org/10.1090/s1079-6762-01-00091-9.
ieee: V. Kaloshin and B. R. Hunt, “A stretched exponential bound on the rate of
growth of the number of periodic points for prevalent diffeomorphisms II,” Electronic
Research Announcements of the American Mathematical Society, vol. 7, no. 5.
American Mathematical Society, pp. 28–36, 2001.
ista: Kaloshin V, Hunt BR. 2001. A stretched exponential bound on the rate of growth
of the number of periodic points for prevalent diffeomorphisms II. Electronic
Research Announcements of the American Mathematical Society. 7(5), 28–36.
mla: Kaloshin, Vadim, and Brian R. Hunt. “A Stretched Exponential Bound on the Rate
of Growth of the Number of Periodic Points for Prevalent Diffeomorphisms II.”
Electronic Research Announcements of the American Mathematical Society,
vol. 7, no. 5, American Mathematical Society, 2001, pp. 28–36, doi:10.1090/s1079-6762-01-00091-9.
short: V. Kaloshin, B.R. Hunt, Electronic Research Announcements of the American
Mathematical Society 7 (2001) 28–36.
date_created: 2020-09-18T10:49:43Z
date_published: 2001-04-24T00:00:00Z
date_updated: 2021-01-12T08:19:51Z
day: '24'
doi: 10.1090/s1079-6762-01-00091-9
extern: '1'
intvolume: ' 7'
issue: '5'
keyword:
- General Mathematics
language:
- iso: eng
month: '04'
oa_version: None
page: 28-36
publication: Electronic Research Announcements of the American Mathematical Society
publication_identifier:
issn:
- 1079-6762
publication_status: published
publisher: American Mathematical Society
quality_controlled: '1'
status: public
title: A stretched exponential bound on the rate of growth of the number of periodic
points for prevalent diffeomorphisms II
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2001'
...
---
_id: '8522'
abstract:
- lang: eng
text: For diffeomorphisms of smooth compact manifolds, we consider the problem of
how fast the number of periodic points with period $n$grows as a function of $n$.
In many familiar cases (e.g., Anosov systems) the growth is exponential, but arbitrarily
fast growth is possible; in fact, the first author has shown that arbitrarily
fast growth is topologically (Baire) generic for $C^2$ or smoother diffeomorphisms.
In the present work we show that, by contrast, for a measure-theoretic notion
of genericity we call ``prevalence'', the growth is not much faster than exponential.
Specifically, we show that for each $\delta > 0$, there is a prevalent set of
( $C^{1+\rho}$ or smoother) diffeomorphisms for which the number of period $n$
points is bounded above by $\operatorname{exp}(C n^{1+\delta})$ for some $C$ independent
of $n$. We also obtain a related bound on the decay of the hyperbolicity of the
periodic points as a function of $n$. The contrast between topologically generic
and measure-theoretically generic behavior for the growth of the number of periodic
points and the decay of their hyperbolicity shows this to be a subtle and complex
phenomenon, reminiscent of KAM theory.
article_processing_charge: No
article_type: original
author:
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
- first_name: Brian R.
full_name: Hunt, Brian R.
last_name: Hunt
citation:
ama: Kaloshin V, Hunt BR. A stretched exponential bound on the rate of growth of
the number of periodic points for prevalent diffeomorphisms I. Electronic Research
Announcements of the American Mathematical Society. 2001;7(4):17-27. doi:10.1090/s1079-6762-01-00090-7
apa: Kaloshin, V., & Hunt, B. R. (2001). A stretched exponential bound on the
rate of growth of the number of periodic points for prevalent diffeomorphisms
I. Electronic Research Announcements of the American Mathematical Society.
American Mathematical Society. https://doi.org/10.1090/s1079-6762-01-00090-7
chicago: Kaloshin, Vadim, and Brian R. Hunt. “A Stretched Exponential Bound on the
Rate of Growth of the Number of Periodic Points for Prevalent Diffeomorphisms
I.” Electronic Research Announcements of the American Mathematical Society.
American Mathematical Society, 2001. https://doi.org/10.1090/s1079-6762-01-00090-7.
ieee: V. Kaloshin and B. R. Hunt, “A stretched exponential bound on the rate of
growth of the number of periodic points for prevalent diffeomorphisms I,” Electronic
Research Announcements of the American Mathematical Society, vol. 7, no. 4.
American Mathematical Society, pp. 17–27, 2001.
ista: Kaloshin V, Hunt BR. 2001. A stretched exponential bound on the rate of growth
of the number of periodic points for prevalent diffeomorphisms I. Electronic Research
Announcements of the American Mathematical Society. 7(4), 17–27.
mla: Kaloshin, Vadim, and Brian R. Hunt. “A Stretched Exponential Bound on the Rate
of Growth of the Number of Periodic Points for Prevalent Diffeomorphisms I.” Electronic
Research Announcements of the American Mathematical Society, vol. 7, no. 4,
American Mathematical Society, 2001, pp. 17–27, doi:10.1090/s1079-6762-01-00090-7.
short: V. Kaloshin, B.R. Hunt, Electronic Research Announcements of the American
Mathematical Society 7 (2001) 17–27.
date_created: 2020-09-18T10:49:56Z
date_published: 2001-04-18T00:00:00Z
date_updated: 2021-01-12T08:19:51Z
day: '18'
doi: 10.1090/s1079-6762-01-00090-7
extern: '1'
intvolume: ' 7'
issue: '4'
keyword:
- General Mathematics
language:
- iso: eng
month: '04'
oa_version: None
page: 17-27
publication: Electronic Research Announcements of the American Mathematical Society
publication_identifier:
issn:
- 1079-6762
publication_status: published
publisher: American Mathematical Society
quality_controlled: '1'
status: public
title: A stretched exponential bound on the rate of growth of the number of periodic
points for prevalent diffeomorphisms I
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2001'
...
---
_id: '8524'
abstract:
- lang: eng
text: 'A number α∈R is diophantine if it is not well approximable by rationals,
i.e. for some C,ε>0 and any relatively prime p,q∈Z we have |αq−p|>Cq−1−ε. It is
well-known and is easy to prove that almost every α in R is diophantine. In this
paper we address a noncommutative version of the diophantine properties. Consider
a pair A,B∈SO(3) and for each n∈Z+ take all possible words in A, A -1, B, and
B - 1 of length n, i.e. for a multiindex I=(i1,i1,…,im,jm) define |I|=∑mk=1(|ik|+|jk|)=n
and \( W_n(A,B ) = \{W_{\cal I}(A,B) = A^{i_1} B^{j_1} \dots A^{i_m} B^{j_m}\}_{|{\cal
I|}=n \).¶Gamburd—Jakobson—Sarnak [GJS] raised the problem: prove that for Haar
almost every pair A,B∈SO(3) the closest distance of words of length n to the identity,
i.e. sA,B(n)=min|I|=n∥WI(A,B)−E∥, is bounded from below by an exponential function
in n. This is the analog of the diophantine property for elements of SO(3). In
this paper we prove that s A,B (n) is bounded from below by an exponential function
in n 2. We also exhibit obstructions to a “simple” proof of the exponential estimate
in n.'
article_processing_charge: No
article_type: original
author:
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
- first_name: I.
full_name: Rodnianski, I.
last_name: Rodnianski
citation:
ama: Kaloshin V, Rodnianski I. Diophantine properties of elements of SO(3). Geometric
And Functional Analysis. 2001;11(5):953-970. doi:10.1007/s00039-001-8222-8
apa: Kaloshin, V., & Rodnianski, I. (2001). Diophantine properties of elements
of SO(3). Geometric And Functional Analysis. Springer Nature. https://doi.org/10.1007/s00039-001-8222-8
chicago: Kaloshin, Vadim, and I. Rodnianski. “Diophantine Properties of Elements
of SO(3).” Geometric And Functional Analysis. Springer Nature, 2001. https://doi.org/10.1007/s00039-001-8222-8.
ieee: V. Kaloshin and I. Rodnianski, “Diophantine properties of elements of SO(3),”
Geometric And Functional Analysis, vol. 11, no. 5. Springer Nature, pp.
953–970, 2001.
ista: Kaloshin V, Rodnianski I. 2001. Diophantine properties of elements of SO(3).
Geometric And Functional Analysis. 11(5), 953–970.
mla: Kaloshin, Vadim, and I. Rodnianski. “Diophantine Properties of Elements of
SO(3).” Geometric And Functional Analysis, vol. 11, no. 5, Springer Nature,
2001, pp. 953–70, doi:10.1007/s00039-001-8222-8.
short: V. Kaloshin, I. Rodnianski, Geometric And Functional Analysis 11 (2001) 953–970.
date_created: 2020-09-18T10:50:11Z
date_published: 2001-12-01T00:00:00Z
date_updated: 2021-01-12T08:19:52Z
day: '01'
doi: 10.1007/s00039-001-8222-8
extern: '1'
intvolume: ' 11'
issue: '5'
language:
- iso: eng
month: '12'
oa_version: None
page: 953-970
publication: Geometric And Functional Analysis
publication_identifier:
issn:
- 1016-443X
- 1420-8970
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Diophantine properties of elements of SO(3)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2001'
...
---
_id: '855'
abstract:
- lang: eng
text: 'Motivation: The context of the start codon (typically, AUG) and the features
of the 5′ Untranslated Regions (5′ UTRs) are important for understanding translation
regulation in eukaryotic mRNAs and for accurate prediction of the coding region
in genomic and cDNA sequences. The presence of AUG triplets in 5′ UTRs (upstream
AUGs) might effect the initiation rate and, in the context of gene prediction,
could reduce the accuracy of the identification of the authentic start. To reveal
potential connections between the presence of upstream AUGs and other features
of 5′ UTRs, such as their length and the start codon context, we undertook a systematic
analysis of the available eukaryotic 5′ UTR sequences. Results: We show that a
large fraction of 5′ UTRs in the available cDNA sequences, 15-53% depending on
the organism, contain upstream ATGs. A negative correlation was observed between
the information content of the translation start signal and the length of the
5′ UTR. Similarly, a negative correlation exists between the ''strength'' of the
start context and the number of upstream ATGs. Typically, cDNAs containing long
5′ UTRs with multiple upstream ATGs have a ''weak'' start context, and in contrast,
cDNAs containing short 5′ UTRs without ATGs have ''strong'' starts. These counter-intuitive
results may be interpreted in terms of upstream AUGs having an important role
in the regulation of translation efficiency by ensuring low basal translation
level via double negative control and creating the potential for additional regulatory
mechanisms. One of such mechanisms, supported by experimental studies of some
mRNAs, includes removal of the AUG-containing portion of the 5′ UTR by alternative
splicing.'
acknowledgement: This work has been partially supported by EU 'TRADAT' project and
by CNR Genetic Engineering (Italy), the RFBR grant for support of scientific schools
(00-15-97968) and SD RAS grant for young scientists (AVK). The authors wish to thank
J.Lyons-Weiler for helpful comments and A. Sorokin for help with the ATG_EVALUATOR
program.
article_processing_charge: No
article_type: original
author:
- first_name: Igor
full_name: Rogozin, Igor
last_name: Rogozin
- first_name: Alex
full_name: Kochetov, Alex
last_name: Kochetov
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Eugene
full_name: Koonin, Eugene
last_name: Koonin
- first_name: Luciano
full_name: Milanesi, Luciano
last_name: Milanesi
citation:
ama: Rogozin I, Kochetov A, Kondrashov F, Koonin E, Milanesi L. Presence of ATG
triplets in 5′ untranslated regions of eukaryotic cDNAs correlates with a ’weak’context
of the start codon. Bioinformatics. 2001;17(10):890-900. doi:10.1093/bioinformatics/17.10.890
apa: Rogozin, I., Kochetov, A., Kondrashov, F., Koonin, E., & Milanesi, L. (2001).
Presence of ATG triplets in 5′ untranslated regions of eukaryotic cDNAs correlates
with a ’weak’context of the start codon. Bioinformatics. Oxford University
Press. https://doi.org/10.1093/bioinformatics/17.10.890
chicago: Rogozin, Igor, Alex Kochetov, Fyodor Kondrashov, Eugene Koonin, and Luciano
Milanesi. “Presence of ATG Triplets in 5′ Untranslated Regions of Eukaryotic CDNAs
Correlates with a ’weak’context of the Start Codon.” Bioinformatics. Oxford
University Press, 2001. https://doi.org/10.1093/bioinformatics/17.10.890.
ieee: I. Rogozin, A. Kochetov, F. Kondrashov, E. Koonin, and L. Milanesi, “Presence
of ATG triplets in 5′ untranslated regions of eukaryotic cDNAs correlates with
a ’weak’context of the start codon,” Bioinformatics, vol. 17, no. 10. Oxford
University Press, pp. 890–900, 2001.
ista: Rogozin I, Kochetov A, Kondrashov F, Koonin E, Milanesi L. 2001. Presence
of ATG triplets in 5′ untranslated regions of eukaryotic cDNAs correlates with
a ’weak’context of the start codon. Bioinformatics. 17(10), 890–900.
mla: Rogozin, Igor, et al. “Presence of ATG Triplets in 5′ Untranslated Regions
of Eukaryotic CDNAs Correlates with a ’weak’context of the Start Codon.” Bioinformatics,
vol. 17, no. 10, Oxford University Press, 2001, pp. 890–900, doi:10.1093/bioinformatics/17.10.890.
short: I. Rogozin, A. Kochetov, F. Kondrashov, E. Koonin, L. Milanesi, Bioinformatics
17 (2001) 890–900.
date_created: 2018-12-11T11:48:52Z
date_published: 2001-10-01T00:00:00Z
date_updated: 2023-06-02T09:08:25Z
day: '01'
doi: 10.1093/bioinformatics/17.10.890
extern: '1'
external_id:
pmid:
- '11673233'
intvolume: ' 17'
issue: '10'
language:
- iso: eng
month: '10'
oa_version: None
page: 890 - 900
pmid: 1
publication: Bioinformatics
publication_identifier:
issn:
- 1367-4803
publication_status: published
publisher: Oxford University Press
publist_id: '6795'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Presence of ATG triplets in 5′ untranslated regions of eukaryotic cDNAs correlates
with a 'weak'context of the start codon
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '2001'
...
---
_id: '867'
abstract:
- lang: eng
text: Genes with new functions often evolve by gene duplication. Alternative splicing
is another means of evolutionary innovation in eukaryotes, which allows a single
gene to encode functionally diverse proteins. We investigate a connection between
these two evolutionary phenomena. For ∼10% of the described cases of substitution
alternative splicing, such that either one or another amino acid sequence is included
into the protein, evidence of origin by tandem exon duplication was found. This
is a conservative estimate because alternative exons are typically short and,
on many occasions, duplicates may have diverged beyond recognition. Dating exon
duplications through a combination of the available experimental data on alternative
splicing in orthologous genes from different species and computational analysis
indicates that most of the duplications antedate at least the radiation of mammalian
orders or even the radiation of vertebrate classes. At present, tandem exon duplication
is the only mechanism of evolution of substitution alternative splicing that can
be specifically demonstrated. Along with gene duplication, this could be a major
route for generating functional diversity during evolution of multicellular eukaryotes.
article_processing_charge: No
article_type: original
author:
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Eugene
full_name: Koonin, Eugene
last_name: Koonin
citation:
ama: Kondrashov F, Koonin E. Origin of alternative splicing by tandem exon duplication.
Human Molecular Genetics. 2001;10(23):2661-2669. doi:10.1093/hmg/10.23.2661
apa: Kondrashov, F., & Koonin, E. (2001). Origin of alternative splicing by
tandem exon duplication. Human Molecular Genetics. Oxford University Press.
https://doi.org/10.1093/hmg/10.23.2661
chicago: Kondrashov, Fyodor, and Eugene Koonin. “Origin of Alternative Splicing
by Tandem Exon Duplication.” Human Molecular Genetics. Oxford University
Press, 2001. https://doi.org/10.1093/hmg/10.23.2661.
ieee: F. Kondrashov and E. Koonin, “Origin of alternative splicing by tandem exon
duplication,” Human Molecular Genetics, vol. 10, no. 23. Oxford University
Press, pp. 2661–2669, 2001.
ista: Kondrashov F, Koonin E. 2001. Origin of alternative splicing by tandem exon
duplication. Human Molecular Genetics. 10(23), 2661–2669.
mla: Kondrashov, Fyodor, and Eugene Koonin. “Origin of Alternative Splicing by Tandem
Exon Duplication.” Human Molecular Genetics, vol. 10, no. 23, Oxford University
Press, 2001, pp. 2661–69, doi:10.1093/hmg/10.23.2661.
short: F. Kondrashov, E. Koonin, Human Molecular Genetics 10 (2001) 2661–2669.
date_created: 2018-12-11T11:48:55Z
date_published: 2001-11-01T00:00:00Z
date_updated: 2023-06-02T08:39:47Z
day: '01'
doi: 10.1093/hmg/10.23.2661
extern: '1'
external_id:
pmid:
- '11726553'
intvolume: ' 10'
issue: '23'
language:
- iso: eng
month: '11'
oa_version: Published Version
page: 2661 - 2669
pmid: 1
publication: Human Molecular Genetics
publication_identifier:
issn:
- 0964-6906
publication_status: published
publisher: Oxford University Press
publist_id: '6777'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Origin of alternative splicing by tandem exon duplication
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 10
year: '2001'
...
---
_id: '874'
abstract:
- lang: eng
text: Sex is thought to facilitate accumulation of initially rare beneficial mutations
by allowing simultaneous allele replacements at many loci. However, this advantage
of sex depends on a restrictive assumption that the fitness of a genotype is determined
by fitness potential, a single intermediate variable to which all loci contribute
additively, so that new alleles can accumulate in any order. Individual-based
simulations of sexual and asexual populations reveal that under generic selection,
sex often retards adaptive evolution. When new alleles are beneficial only if
they accumulate in a prescribed order, a sexual population may evolve two or more
times slower than an asexual population because only asexual reproduction allows
some overlap of successive allele replacements. Many other fitness surfaces lead
to an even greater disadvantage of sex. Thus, either sex exists in spite of its
impact on the rate of adaptive allele replacements, or natural fitness surfaces
have rather specific properties, at least at the scale of intrapopulation genetic
variability.
article_processing_charge: No
article_type: original
author:
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Alexey
full_name: Kondrashov, Alexey
last_name: Kondrashov
citation:
ama: Kondrashov F, Kondrashov A. Multidimensional epistasis and the disadvantage
of sex. PNAS. 2001;98(21):12089-12092. doi:10.1073/pnas.211214298
apa: Kondrashov, F., & Kondrashov, A. (2001). Multidimensional epistasis and
the disadvantage of sex. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.211214298
chicago: Kondrashov, Fyodor, and Alexey Kondrashov. “Multidimensional Epistasis
and the Disadvantage of Sex.” PNAS. National Academy of Sciences, 2001.
https://doi.org/10.1073/pnas.211214298.
ieee: F. Kondrashov and A. Kondrashov, “Multidimensional epistasis and the disadvantage
of sex,” PNAS, vol. 98, no. 21. National Academy of Sciences, pp. 12089–12092,
2001.
ista: Kondrashov F, Kondrashov A. 2001. Multidimensional epistasis and the disadvantage
of sex. PNAS. 98(21), 12089–12092.
mla: Kondrashov, Fyodor, and Alexey Kondrashov. “Multidimensional Epistasis and
the Disadvantage of Sex.” PNAS, vol. 98, no. 21, National Academy of Sciences,
2001, pp. 12089–92, doi:10.1073/pnas.211214298.
short: F. Kondrashov, A. Kondrashov, PNAS 98 (2001) 12089–12092.
date_created: 2018-12-11T11:48:58Z
date_published: 2001-10-09T00:00:00Z
date_updated: 2023-06-02T08:18:22Z
day: '09'
doi: 10.1073/pnas.211214298
extern: '1'
external_id:
pmid:
- '11593020'
intvolume: ' 98'
issue: '21'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59772/
month: '10'
oa: 1
oa_version: Published Version
page: 12089 - 12092
pmid: 1
publication: PNAS
publication_identifier:
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
publist_id: '6774'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Multidimensional epistasis and the disadvantage of sex
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 98
year: '2001'
...