--- OA_place: publisher OA_type: hybrid _id: '18170' abstract: - lang: eng text: 'This study presents a graphene field-effect transistor (gFET) biosensor with dual detection capabilities for SARS-CoV-2: one RNA detection assay to confirm viral positivity and the other for nucleocapsid (N-)protein detection as a proxy for infectiousness of the patient. This technology can be rapidly adapted to emerging infectious diseases, making an essential tool to contain future pandemics. To detect viral RNA, the highly conserved E-gene of the virus was targeted, allowing for the determination of SARS-CoV-2 presence or absence using nasopharyngeal swab samples. For N-protein detection, specific antibodies were used. Tested on 213 clinical nasopharyngeal samples, the gFET biosensor showed good correlation with RT-PCR cycle threshold values, proving its high sensitivity in detecting SARS-CoV-2 RNA. Specificity was confirmed using 21 pre-pandemic samples positive for other respiratory viruses. The gFET biosensor had a limit of detection (LOD) for N-protein of 0.9 pM, establishing a foundation for the development of a sensitive tool for monitoring active viral infection. Results of gFET based N-protein detection corresponded to the results of virus culture in all 16 available clinical samples and thus it also proved its capability to serve as a proxy for infectivity. Overall, these findings support the potential of the gFET biosensor as a point-of-care device for rapid diagnosis of SARS-CoV-2 infection and indirect assessment of infectiousness in patients, providing additional information for clinical and public health decision-making.' acknowledgement: 'This research was funded in whole by the Austrian Science Fund (FWF) [P 35103-B, Grant-DOI: 10.55776/P35103]. For open access purposes, the author has applied a CC BY public copyright license to any author-accepted manuscript version arising from this submission. We would like to thank Olfert Landt for advice on ssDNA probe design; Rui Qiang Chen, Jennifer Stock, and Christine Wukotitsch for their excellent support with ONT sequencing; Christoph Köppl and Andreas Fischer for excellent support in recombinant N protein expression and purification; and the whole team at the division of clinical virology for their support with standard diagnostics.' article_number: '116807' article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Anna Nele full_name: Herdina, Anna Nele last_name: Herdina - first_name: Anil full_name: Bozdogan, Anil last_name: Bozdogan - first_name: Patrik full_name: Aspermair, Patrik last_name: Aspermair - first_name: Jakub full_name: Dostalek, Jakub last_name: Dostalek - first_name: Miriam full_name: Klausberger, Miriam last_name: Klausberger - first_name: Nico full_name: Lingg, Nico last_name: Lingg - first_name: Monika full_name: Cserjan-Puschmann, Monika last_name: Cserjan-Puschmann - first_name: Patricia Pereira full_name: Aguilar, Patricia Pereira last_name: Aguilar - first_name: Simone full_name: Auer, Simone last_name: Auer - first_name: Halil full_name: Demirtas, Halil last_name: Demirtas - first_name: Jakob full_name: Andersson, Jakob id: 3a5f4167-9bd9-11ed-bd12-a1446d38776f last_name: Andersson - first_name: Felix full_name: Lötsch, Felix last_name: Lötsch - first_name: Barbara full_name: Holzer, Barbara last_name: Holzer - first_name: Adi full_name: Steinrigl, Adi last_name: Steinrigl - first_name: Florian full_name: Thalhammer, Florian last_name: Thalhammer - first_name: Julia full_name: Schellnegger, Julia last_name: Schellnegger - first_name: Monika full_name: Breuer, Monika last_name: Breuer - first_name: Wolfgang full_name: Knoll, Wolfgang last_name: Knoll - first_name: Robert full_name: Strassl, Robert last_name: Strassl citation: ama: 'Herdina AN, Bozdogan A, Aspermair P, et al. Bridging basic science and applied diagnostics: Comprehensive viral diagnostics enabled by graphene-based electronic biosensor technology advancements. Biosensors and Bioelectronics. 2025;267. doi:10.1016/j.bios.2024.116807' apa: 'Herdina, A. N., Bozdogan, A., Aspermair, P., Dostalek, J., Klausberger, M., Lingg, N., … Strassl, R. (2025). Bridging basic science and applied diagnostics: Comprehensive viral diagnostics enabled by graphene-based electronic biosensor technology advancements. Biosensors and Bioelectronics. Elsevier. https://doi.org/10.1016/j.bios.2024.116807' chicago: 'Herdina, Anna Nele, Anil Bozdogan, Patrik Aspermair, Jakub Dostalek, Miriam Klausberger, Nico Lingg, Monika Cserjan-Puschmann, et al. “Bridging Basic Science and Applied Diagnostics: Comprehensive Viral Diagnostics Enabled by Graphene-Based Electronic Biosensor Technology Advancements.” Biosensors and Bioelectronics. Elsevier, 2025. https://doi.org/10.1016/j.bios.2024.116807.' ieee: 'A. N. Herdina et al., “Bridging basic science and applied diagnostics: Comprehensive viral diagnostics enabled by graphene-based electronic biosensor technology advancements,” Biosensors and Bioelectronics, vol. 267. Elsevier, 2025.' ista: 'Herdina AN, Bozdogan A, Aspermair P, Dostalek J, Klausberger M, Lingg N, Cserjan-Puschmann M, Aguilar PP, Auer S, Demirtas H, Andersson J, Lötsch F, Holzer B, Steinrigl A, Thalhammer F, Schellnegger J, Breuer M, Knoll W, Strassl R. 2025. Bridging basic science and applied diagnostics: Comprehensive viral diagnostics enabled by graphene-based electronic biosensor technology advancements. Biosensors and Bioelectronics. 267, 116807.' mla: 'Herdina, Anna Nele, et al. “Bridging Basic Science and Applied Diagnostics: Comprehensive Viral Diagnostics Enabled by Graphene-Based Electronic Biosensor Technology Advancements.” Biosensors and Bioelectronics, vol. 267, 116807, Elsevier, 2025, doi:10.1016/j.bios.2024.116807.' short: A.N. Herdina, A. Bozdogan, P. Aspermair, J. Dostalek, M. Klausberger, N. Lingg, M. Cserjan-Puschmann, P.P. Aguilar, S. Auer, H. Demirtas, J. Andersson, F. Lötsch, B. Holzer, A. Steinrigl, F. Thalhammer, J. Schellnegger, M. Breuer, W. Knoll, R. Strassl, Biosensors and Bioelectronics 267 (2025). date_created: 2024-10-06T22:01:11Z date_published: 2025-01-01T00:00:00Z date_updated: 2025-02-27T12:34:07Z day: '01' ddc: - '570' department: - _id: LeSa doi: 10.1016/j.bios.2024.116807 external_id: isi: - '001328413700001' pmid: - '39341071' file: - access_level: open_access checksum: 208ac27dab27af792d198fcb74af8756 content_type: application/pdf creator: dernst date_created: 2025-01-13T11:14:32Z date_updated: 2025-01-13T11:14:32Z file_id: '18843' file_name: 2025_BiosensorsBioelectronics_Herdina.pdf file_size: 4135372 relation: main_file success: 1 file_date_updated: 2025-01-13T11:14:32Z has_accepted_license: '1' intvolume: ' 267' isi: 1 language: - iso: eng month: '01' oa: 1 oa_version: Published Version pmid: 1 publication: Biosensors and Bioelectronics publication_identifier: eissn: - 1873-4235 issn: - 0956-5663 publication_status: published publisher: Elsevier quality_controlled: '1' scopus_import: '1' status: public title: 'Bridging basic science and applied diagnostics: Comprehensive viral diagnostics enabled by graphene-based electronic biosensor technology advancements' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 267 year: '2025' ... --- OA_place: repository OA_type: green _id: '22021' abstract: - lang: eng text: "We establish global well-posedness for both the defocusing and\r\nfocusing complex-valued modified Korteweg–de Vries equations on the real line\r\nin modulation spaces Ms,2p (R), for all 1 \x14 p < 1 and 0 \x14 s < 3/2 − 1/p. We\r\nwill also show that such solutions admit global-in-time bounds in these spaces\r\nand that equicontinuous sets of initial data lead to equicontinuous ensembles\r\nof orbits. Indeed, such information forms a crucial part of our well-posedness\r\nargument." article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Saikatul full_name: Haque, Saikatul last_name: Haque - first_name: Rowan full_name: Killip, Rowan last_name: Killip - first_name: Monica full_name: Visan, Monica id: 056daca0-b8d1-11f0-964f-f91054abf8ca last_name: Visan - first_name: Yunfeng full_name: Zhang, Yunfeng last_name: Zhang citation: ama: Haque S, Killip R, Vişan M, Zhang Y. Global well-posedness and equicontinuity for modified Korteweg–de Vries equations in modulation spaces. Pure and Applied Analysis. 2025;7(3):615-637. doi:10.2140/paa.2025.7.615 apa: Haque, S., Killip, R., Vişan, M., & Zhang, Y. (2025). Global well-posedness and equicontinuity for modified Korteweg–de Vries equations in modulation spaces. Pure and Applied Analysis. Mathematical Sciences Publishers. https://doi.org/10.2140/paa.2025.7.615 chicago: Haque, Saikatul, Rowan Killip, Monica Vişan, and Yunfeng Zhang. “ Global Well-Posedness and Equicontinuity for Modified Korteweg–de Vries Equations in Modulation Spaces.” Pure and Applied Analysis. Mathematical Sciences Publishers, 2025. https://doi.org/10.2140/paa.2025.7.615. ieee: S. Haque, R. Killip, M. Vişan, and Y. Zhang, “ Global well-posedness and equicontinuity for modified Korteweg–de Vries equations in modulation spaces,” Pure and Applied Analysis, vol. 7, no. 3. Mathematical Sciences Publishers, pp. 615–637, 2025. ista: Haque S, Killip R, Vişan M, Zhang Y. 2025. Global well-posedness and equicontinuity for modified Korteweg–de Vries equations in modulation spaces. Pure and Applied Analysis. 7(3), 615–637. mla: Haque, Saikatul, et al. “ Global Well-Posedness and Equicontinuity for Modified Korteweg–de Vries Equations in Modulation Spaces.” Pure and Applied Analysis, vol. 7, no. 3, Mathematical Sciences Publishers, 2025, pp. 615–37, doi:10.2140/paa.2025.7.615. short: S. Haque, R. Killip, M. Vişan, Y. Zhang, Pure and Applied Analysis 7 (2025) 615–637. das_tickbox: '1' date_created: 2026-06-19T07:30:23Z date_published: 2025-06-18T00:00:00Z date_updated: 2026-06-24T13:22:40Z day: '18' doi: 10.2140/paa.2025.7.615 extern: '1' external_id: arxiv: - '2411.05300' intvolume: ' 7' issue: '3' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2411.05300 mathsc: - 35Q53 - 35Q55 - 37K10 month: '06' oa: 1 oa_version: Preprint page: 615-637 publication: Pure and Applied Analysis publication_identifier: eissn: - 2578-5885 issn: - 2578-5893 publication_status: published publisher: Mathematical Sciences Publishers quality_controlled: '1' scopus_import: '1' status: public title: ' Global well-posedness and equicontinuity for modified Korteweg–de Vries equations in modulation spaces' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 7 year: '2025' ... --- OA_place: repository OA_type: green _id: '22027' abstract: - lang: eng text: We demonstrate that in three space dimensions, the scattering behaviour of semilinear wave equations with quintic-type nonlinearities uniquely determines the nonlinearity. The nonlinearity is permitted to depend on both space and time. article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Nicholas full_name: Hu, Nicholas last_name: Hu - first_name: Rowan full_name: Killip, Rowan last_name: Killip - first_name: Monica full_name: Visan, Monica id: 056daca0-b8d1-11f0-964f-f91054abf8ca last_name: Visan citation: ama: Hu N, Killip R, Vişan M. Deconvolutional determination of the nonlinearity in a semilinear wave equation. Pure and Applied Analysis. 2025;7(1):1-17. doi:10.2140/paa.2025.7.1 apa: Hu, N., Killip, R., & Vişan, M. (2025). Deconvolutional determination of the nonlinearity in a semilinear wave equation. Pure and Applied Analysis. Mathematical Sciences Publishers. https://doi.org/10.2140/paa.2025.7.1 chicago: Hu, Nicholas, Rowan Killip, and Monica Vişan. “Deconvolutional Determination of the Nonlinearity in a Semilinear Wave Equation.” Pure and Applied Analysis. Mathematical Sciences Publishers, 2025. https://doi.org/10.2140/paa.2025.7.1. ieee: N. Hu, R. Killip, and M. Vişan, “Deconvolutional determination of the nonlinearity in a semilinear wave equation,” Pure and Applied Analysis, vol. 7, no. 1. Mathematical Sciences Publishers, pp. 1–17, 2025. ista: Hu N, Killip R, Vişan M. 2025. Deconvolutional determination of the nonlinearity in a semilinear wave equation. Pure and Applied Analysis. 7(1), 1–17. mla: Hu, Nicholas, et al. “Deconvolutional Determination of the Nonlinearity in a Semilinear Wave Equation.” Pure and Applied Analysis, vol. 7, no. 1, Mathematical Sciences Publishers, 2025, pp. 1–17, doi:10.2140/paa.2025.7.1. short: N. Hu, R. Killip, M. Vişan, Pure and Applied Analysis 7 (2025) 1–17. date_created: 2026-06-19T07:36:00Z date_published: 2025-01-22T00:00:00Z date_updated: 2026-06-24T13:24:38Z day: '22' doi: 10.2140/paa.2025.7.1 extern: '1' external_id: arxiv: - '2307.00829' intvolume: ' 7' issue: '1' keyword: - dispersive equations - nonlinear wave equation - semilinear wave equation - scattering - inverse scattering - deconvolution language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2307.00829 mathsc: - 35L70 - 35P25 - 35R30 month: '01' oa: 1 oa_version: Preprint page: 1-17 publication: Pure and Applied Analysis publication_identifier: eissn: - 2578-5885 issn: - 2578-5893 publication_status: published publisher: Mathematical Sciences Publishers quality_controlled: '1' scopus_import: '1' status: public title: Deconvolutional determination of the nonlinearity in a semilinear wave equation type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 7 year: '2025' ... --- OA_place: repository OA_type: green _id: '22044' abstract: - lang: eng text: We prove that the small-data scattering map uniquely determines the nonlinearity for a wide class of gauge-invariant, intercritical nonlinear Schrödinger equations. We use the Born approximation to reduce the analysis to a deconvolution problem involving the distribution function for linear Schrödinger solutions. We then solve this deconvolution problem using the Beurling–Lax Theorem. article_number: '015021' article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Rowan full_name: Killip, Rowan last_name: Killip - first_name: Jason full_name: Murphy, Jason last_name: Murphy - first_name: Monica full_name: Visan, Monica id: 056daca0-b8d1-11f0-964f-f91054abf8ca last_name: Visan citation: ama: Killip R, Murphy J, Vişan M. Determination of Schrödinger nonlinearities from the scattering map. Nonlinearity. 2025;38(1). doi:10.1088/1361-6544/ada1bf apa: Killip, R., Murphy, J., & Vişan, M. (2025). Determination of Schrödinger nonlinearities from the scattering map. Nonlinearity. IOP Publishing. https://doi.org/10.1088/1361-6544/ada1bf chicago: Killip, Rowan, Jason Murphy, and Monica Vişan. “Determination of Schrödinger Nonlinearities from the Scattering Map.” Nonlinearity. IOP Publishing, 2025. https://doi.org/10.1088/1361-6544/ada1bf. ieee: R. Killip, J. Murphy, and M. Vişan, “Determination of Schrödinger nonlinearities from the scattering map,” Nonlinearity, vol. 38, no. 1. IOP Publishing, 2025. ista: Killip R, Murphy J, Vişan M. 2025. Determination of Schrödinger nonlinearities from the scattering map. Nonlinearity. 38(1), 015021. mla: Killip, Rowan, et al. “Determination of Schrödinger Nonlinearities from the Scattering Map.” Nonlinearity, vol. 38, no. 1, 015021, IOP Publishing, 2025, doi:10.1088/1361-6544/ada1bf. short: R. Killip, J. Murphy, M. Vişan, Nonlinearity 38 (2025). das_tickbox: '1' date_created: 2026-06-19T07:47:06Z date_published: 2025-01-01T00:00:00Z date_updated: 2026-06-25T07:46:14Z day: '01' doi: 10.1088/1361-6544/ada1bf extern: '1' external_id: arxiv: - '2402.03218' intvolume: ' 38' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2402.03218 month: '01' oa: 1 oa_version: Preprint publication: Nonlinearity publication_identifier: eissn: - 1361-6544 issn: - 0951-7715 publication_status: published publisher: IOP Publishing quality_controlled: '1' scopus_import: '1' status: public title: Determination of Schrödinger nonlinearities from the scattering map type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 38 year: '2025' ... --- OA_place: repository OA_type: green _id: '22069' abstract: - lang: eng text: "For slowly-varying initial data, solutions to the Ablowitz–Ladik system have been proven to converge to solutions of the cubic Schrödinger equation. In this paper we show that in the continuum limit, solutions to the Ablowitz–Ladik system with H^1 initial data may also converge to solutions of the modified Korteweg–de Vries equation. To exhibit this new limiting behavior, it suffices that the initial data is supported near the inflection points of the dispersion relation associated with the Ablowitz–Ladik system.\r\n\r\nOur arguments employ harmonic analysis tools, Strichartz estimates, and the conservation of mass and energy. Correspondingly, they are applicable beyond the completely integrable models of greatest interest to us." article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Rowan full_name: Killip, Rowan last_name: Killip - first_name: Zhimeng full_name: Ouyang, Zhimeng last_name: Ouyang - first_name: Monica full_name: Visan, Monica id: 056daca0-b8d1-11f0-964f-f91054abf8ca last_name: Visan - first_name: Lei full_name: Wu, Lei last_name: Wu citation: ama: Killip R, Ouyang Z, Vişan M, Wu L. The modified Korteweg–de Vries limit of the Ablowitz–Ladik system. Discrete and Continuous Dynamical Systems. 2025;45(3):821-846. doi:10.3934/dcds.2024114 apa: Killip, R., Ouyang, Z., Vişan, M., & Wu, L. (2025). The modified Korteweg–de Vries limit of the Ablowitz–Ladik system. Discrete and Continuous Dynamical Systems. American Institute of Mathematical Sciences. https://doi.org/10.3934/dcds.2024114 chicago: Killip, Rowan, Zhimeng Ouyang, Monica Vişan, and Lei Wu. “The Modified Korteweg–de Vries Limit of the Ablowitz–Ladik System.” Discrete and Continuous Dynamical Systems. American Institute of Mathematical Sciences, 2025. https://doi.org/10.3934/dcds.2024114. ieee: R. Killip, Z. Ouyang, M. Vişan, and L. Wu, “The modified Korteweg–de Vries limit of the Ablowitz–Ladik system,” Discrete and Continuous Dynamical Systems, vol. 45, no. 3. American Institute of Mathematical Sciences, pp. 821–846, 2025. ista: Killip R, Ouyang Z, Vişan M, Wu L. 2025. The modified Korteweg–de Vries limit of the Ablowitz–Ladik system. Discrete and Continuous Dynamical Systems. 45(3), 821–846. mla: Killip, Rowan, et al. “The Modified Korteweg–de Vries Limit of the Ablowitz–Ladik System.” Discrete and Continuous Dynamical Systems, vol. 45, no. 3, American Institute of Mathematical Sciences, 2025, pp. 821–46, doi:10.3934/dcds.2024114. short: R. Killip, Z. Ouyang, M. Vişan, L. Wu, Discrete and Continuous Dynamical Systems 45 (2025) 821–846. das_tickbox: '1' date_created: 2026-06-19T08:20:28Z date_published: 2025-03-01T00:00:00Z date_updated: 2026-06-30T07:34:20Z day: '01' ddc: - '500' doi: 10.3934/dcds.2024114 extern: '1' external_id: arxiv: - '2404.02366' intvolume: ' 45' issue: '3' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2404.02366 mathsc: - 37J70 - 37K10 - 37K60 - 35Q53 - 35Q55 month: '03' oa: 1 oa_version: Preprint page: 821-846 publication: Discrete and Continuous Dynamical Systems publication_identifier: eissn: - 1553-5231 issn: - 1078-0947 publication_status: published publisher: American Institute of Mathematical Sciences quality_controlled: '1' scopus_import: '1' status: public title: The modified Korteweg–de Vries limit of the Ablowitz–Ladik system type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 45 year: '2025' ... --- OA_place: repository OA_type: green _id: '22083' abstract: - lang: eng text: We prove global well-posedness for the cubic nonlinear Schrödinger equation with nonlinearity concentrated on a homogeneous Poisson process. article_number: '095020' article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Benjamin full_name: Harrop-Griffiths, Benjamin last_name: Harrop-Griffiths - first_name: Rowan full_name: Killip, Rowan last_name: Killip - first_name: Monica full_name: Visan, Monica id: 056daca0-b8d1-11f0-964f-f91054abf8ca last_name: Visan citation: ama: Harrop-Griffiths B, Killip R, Vişan M. The nonlinear Schrödinger equation with sprinkled nonlinearity. Nonlinearity. 2025;38(9). doi:10.1088/1361-6544/ae022e apa: Harrop-Griffiths, B., Killip, R., & Vişan, M. (2025). The nonlinear Schrödinger equation with sprinkled nonlinearity. Nonlinearity. IOP Publishing. https://doi.org/10.1088/1361-6544/ae022e chicago: Harrop-Griffiths, Benjamin, Rowan Killip, and Monica Vişan. “The Nonlinear Schrödinger Equation with Sprinkled Nonlinearity.” Nonlinearity. IOP Publishing, 2025. https://doi.org/10.1088/1361-6544/ae022e. ieee: B. Harrop-Griffiths, R. Killip, and M. Vişan, “The nonlinear Schrödinger equation with sprinkled nonlinearity,” Nonlinearity, vol. 38, no. 9. IOP Publishing, 2025. ista: Harrop-Griffiths B, Killip R, Vişan M. 2025. The nonlinear Schrödinger equation with sprinkled nonlinearity. Nonlinearity. 38(9), 095020. mla: Harrop-Griffiths, Benjamin, et al. “The Nonlinear Schrödinger Equation with Sprinkled Nonlinearity.” Nonlinearity, vol. 38, no. 9, 095020, IOP Publishing, 2025, doi:10.1088/1361-6544/ae022e. short: B. Harrop-Griffiths, R. Killip, M. Vişan, Nonlinearity 38 (2025). das_tickbox: '1' date_created: 2026-06-19T08:27:54Z date_published: 2025-09-15T00:00:00Z date_updated: 2026-07-01T07:17:44Z day: '15' doi: 10.1088/1361-6544/ae022e extern: '1' external_id: arxiv: - '2405.01246' intvolume: ' 38' issue: '9' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2405.01246 month: '09' oa: 1 oa_version: Preprint publication: Nonlinearity publication_identifier: eissn: - 1361-6544 issn: - 0951-7715 publication_status: published publisher: IOP Publishing quality_controlled: '1' scopus_import: '1' status: public title: The nonlinear Schrödinger equation with sprinkled nonlinearity type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 38 year: '2025' ... --- OA_place: publisher OA_type: gold _id: '22120' article_number: EGU25-17446 article_processing_charge: No author: - first_name: José M full_name: Muñoz Hermosilla, José M id: e1037a6d-646e-11ef-b402-e0ed9ab0901e last_name: Muñoz Hermosilla orcid: 0000-0002-1990-8508 - first_name: Evan full_name: Miles, Evan last_name: Miles - first_name: Michael full_name: McCarthy, Michael id: 22a2674a-61ce-11ee-94b5-d18813baf16f last_name: McCarthy - first_name: Florian full_name: Hardmeier, Florian last_name: Hardmeier - first_name: Juan Vicente full_name: Melo Velasco, Juan Vicente id: 2611dec0-b9c6-11ed-9bea-a81c2b17a549 last_name: Melo Velasco - first_name: Guillaume full_name: Jouvet, Guillaume last_name: Jouvet - first_name: Francesca full_name: Pellicciotti, Francesca id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70 last_name: Pellicciotti orcid: 0000-0002-5554-8087 citation: ama: 'Muñoz Hermosilla JM, Miles E, McCarthy M, et al. Towards reconstructing debris supply to reproduce the historic changes in debris extent at a Swiss glacier. In: EGU General Assembly 2025. European Geosciences Union; 2025. doi:10.5194/egusphere-egu25-17446' apa: 'Muñoz Hermosilla, J. M., Miles, E., McCarthy, M., Hardmeier, F., Melo Velasco, J. V., Jouvet, G., & Pellicciotti, F. (2025). Towards reconstructing debris supply to reproduce the historic changes in debris extent at a Swiss glacier. In EGU General Assembly 2025. Vienna, Austria & Virtual: European Geosciences Union. https://doi.org/10.5194/egusphere-egu25-17446' chicago: Muñoz Hermosilla, José M, Evan Miles, Michael McCarthy, Florian Hardmeier, Juan Vicente Melo Velasco, Guillaume Jouvet, and Francesca Pellicciotti. “Towards Reconstructing Debris Supply to Reproduce the Historic Changes in Debris Extent at a Swiss Glacier.” In EGU General Assembly 2025. European Geosciences Union, 2025. https://doi.org/10.5194/egusphere-egu25-17446. ieee: J. M. Muñoz Hermosilla et al., “Towards reconstructing debris supply to reproduce the historic changes in debris extent at a Swiss glacier,” in EGU General Assembly 2025, Vienna, Austria & Virtual, 2025. ista: Muñoz Hermosilla JM, Miles E, McCarthy M, Hardmeier F, Melo Velasco JV, Jouvet G, Pellicciotti F. 2025. Towards reconstructing debris supply to reproduce the historic changes in debris extent at a Swiss glacier. EGU General Assembly 2025. EGU General Assembly, EGU25-17446. mla: Muñoz Hermosilla, José M., et al. “Towards Reconstructing Debris Supply to Reproduce the Historic Changes in Debris Extent at a Swiss Glacier.” EGU General Assembly 2025, EGU25-17446, European Geosciences Union, 2025, doi:10.5194/egusphere-egu25-17446. short: J.M. Muñoz Hermosilla, E. Miles, M. McCarthy, F. Hardmeier, J.V. Melo Velasco, G. Jouvet, F. Pellicciotti, in:, EGU General Assembly 2025, European Geosciences Union, 2025. conference: end_date: 2025-05-02 location: Vienna, Austria & Virtual name: EGU General Assembly start_date: 2025-04-27 date_created: 2026-06-22T12:17:47Z date_published: 2025-05-14T00:00:00Z date_updated: 2026-07-02T06:41:43Z day: '14' ddc: - '550' department: - _id: FrPe - _id: GradSch doi: 10.5194/egusphere-egu25-17446 has_accepted_license: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.5194/egusphere-egu25-17446 month: '05' oa: 1 oa_version: Published Version publication: EGU General Assembly 2025 publication_status: published publisher: European Geosciences Union status: public title: Towards reconstructing debris supply to reproduce the historic changes in debris extent at a Swiss glacier tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: conference_abstract user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2025' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: diamond PlanS_conform: '1' _id: '21263' abstract: - lang: eng text: Two landmark results in combinatorial random matrix theory, due to Komlós and Costello–Tao–Vu, show that discrete random matrices and symmetric discrete random matrices are typically nonsingular. In particular, in the language of graph theory, when p is a fixed constant, the biadjacency matrix of a random Erdős–Rényi bipartite graph G(n,n,p) and the adjacency matrix of an Erdős–Rényi random graph G(n,p) are both nonsingular with high probability. However, very sparse random graphs (i.e., where p is allowed to decay rapidly with n) are typically singular, due to the presence of “local” dependencies such as isolated vertices and pairs of degree-1 vertices with the same neighbour. In this paper, we give a combinatorial description of the rank of a sparse random graph G(n,n,c/n) or G(n,c/n) in terms of such local dependencies, for all constants c=e (and we present some evidence that the situation is very different for c=e). This gives an essentially complete answer to a question raised by Vu (2014). As applications of our main theorem and its proof, we also determine the asymptotic singularity probability of the 2-core of a sparse random graph, we show that the rank of a sparse random graph is extremely well approximated by its matching number, and we deduce a central limit theorem for the rank of G(n,c/n). acknowledgement: "We would like to thank Noga Alon for suggesting that our main result gives\r\na linear-time algorithm for computing the rank. We also thank the referees for a number of thoughtful comments and suggestions. Glasgow was supported by NSF graduate research fellowship program award DGE1656518. Kwan was supported by ERC Starting Grant “RANDSTRUCT” No. 101076777. Sah and Sawhney were supported by NSF Graduate Research Fellowship Program DGE-1745302.\r\n" article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Margalit full_name: Glasgow, Margalit last_name: Glasgow - first_name: Matthew Alan full_name: Kwan, Matthew Alan id: 5fca0887-a1db-11eb-95d1-ca9d5e0453b3 last_name: Kwan orcid: 0000-0002-4003-7567 - first_name: Ashwin full_name: Sah, Ashwin last_name: Sah - first_name: Mehtaab full_name: Sawhney, Mehtaab last_name: Sawhney citation: ama: Glasgow M, Kwan MA, Sah A, Sawhney M. The exact rank of sparse random graphs. Journal of the European Mathematical Society. 2025. doi:10.4171/jems/1692 apa: Glasgow, M., Kwan, M. A., Sah, A., & Sawhney, M. (2025). The exact rank of sparse random graphs. Journal of the European Mathematical Society. EMS Press. https://doi.org/10.4171/jems/1692 chicago: Glasgow, Margalit, Matthew Alan Kwan, Ashwin Sah, and Mehtaab Sawhney. “The Exact Rank of Sparse Random Graphs.” Journal of the European Mathematical Society. EMS Press, 2025. https://doi.org/10.4171/jems/1692. ieee: M. Glasgow, M. A. Kwan, A. Sah, and M. Sawhney, “The exact rank of sparse random graphs,” Journal of the European Mathematical Society. EMS Press, 2025. ista: Glasgow M, Kwan MA, Sah A, Sawhney M. 2025. The exact rank of sparse random graphs. Journal of the European Mathematical Society. mla: Glasgow, Margalit, et al. “The Exact Rank of Sparse Random Graphs.” Journal of the European Mathematical Society, EMS Press, 2025, doi:10.4171/jems/1692. short: M. Glasgow, M.A. Kwan, A. Sah, M. Sawhney, Journal of the European Mathematical Society (2025). corr_author: '1' das_tickbox: '1' date_created: 2026-02-17T07:41:59Z date_published: 2025-09-02T00:00:00Z date_updated: 2026-07-06T11:51:31Z day: '02' ddc: - '510' department: - _id: MaKw doi: 10.4171/jems/1692 external_id: arxiv: - '2303.05435' has_accepted_license: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.4171/JEMS/1692 month: '09' oa: 1 oa_version: Published Version project: - _id: bd95085b-d553-11ed-ba76-e55d3349be45 grant_number: '101076777' name: Randomness and structure in combinatorics publication: Journal of the European Mathematical Society publication_identifier: eissn: - 1435-9863 issn: - 1435-9855 publication_status: epub_ahead publisher: EMS Press quality_controlled: '1' status: public title: The exact rank of sparse random graphs tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2025' ... --- OA_place: repository _id: '21427' abstract: - lang: eng text: While tumor malignancy has been extensively studied under the prism of genetic and epigenetic heterogeneity, tumor cell states also critically depend on reciprocal interactions with the microenvironment. This raises the hitherto untested possibility that heterogeneity of the untransformed tumor stroma can actively fuel malignant progression. As biological heterogeneity is inherently difficult to control, we adopted a reductionist approach and let tumor cells invade micro-engineered environments harboring obstacles with precision-controlled geometry. We find that not only the presence of obstacles, but more surprisingly their spatial disorder, causes a drastic shift from a collective to a single-cell mode of invasion – comparable in strength to cadherin loss. Combining live-imaging and perturbation experiments with minimal biophysical modeling, we demonstrate that cell detachments result both from local geometrical constraints and a global integration of spatial disorder over time. We show that different types of microenvironments map onto different universality classes of invasion dynamics - homogeneous substrates follow Kardar–Parisi–Zhang (KPZ) scaling, while disordered ones exhibit exponents consistent with KPZ with quenched disorder (KPZq). Our findings highlight generic physical principles for how the mode of cancer cell invasion depends on environmental heterogeneity, with potential implications to understand tumor evolution in vivo. acknowledgement: "European Research Council, https://ror.org/0472cxd90, 101071793\r\nAustrian Academy of Sciences, 26360" article_processing_charge: No author: - first_name: Zuzana full_name: Dunajova, Zuzana id: 4B39F286-F248-11E8-B48F-1D18A9856A87 last_name: Dunajova - first_name: Saren full_name: Tasciyan, Saren id: 4323B49C-F248-11E8-B48F-1D18A9856A87 last_name: Tasciyan orcid: 0000-0003-1671-393X - first_name: Juraj full_name: Majek, Juraj id: 3e6d9473-f38e-11ec-8ae0-c4e05a8aa9e1 last_name: Majek - first_name: Jack full_name: Merrin, Jack id: 4515C308-F248-11E8-B48F-1D18A9856A87 last_name: Merrin orcid: 0000-0001-5145-4609 - first_name: Erik full_name: Sahai, Erik last_name: Sahai - first_name: Michael K full_name: Sixt, Michael K id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87 last_name: Sixt orcid: 0000-0002-6620-9179 - first_name: Edouard B full_name: Hannezo, Edouard B id: 3A9DB764-F248-11E8-B48F-1D18A9856A87 last_name: Hannezo orcid: 0000-0001-6005-1561 citation: ama: Dunajova Z, Tasciyan S, Majek J, et al. Substrate heterogeneity promotes cancer cell dissemination through interface roughening. bioRxiv. doi:10.1101/2025.05.20.655037 apa: Dunajova, Z., Tasciyan, S., Majek, J., Merrin, J., Sahai, E., Sixt, M. K., & Hannezo, E. B. (n.d.). Substrate heterogeneity promotes cancer cell dissemination through interface roughening. bioRxiv. https://doi.org/10.1101/2025.05.20.655037 chicago: Dunajova, Zuzana, Saren Tasciyan, Juraj Majek, Jack Merrin, Erik Sahai, Michael K Sixt, and Edouard B Hannezo. “Substrate Heterogeneity Promotes Cancer Cell Dissemination through Interface Roughening.” BioRxiv, n.d. https://doi.org/10.1101/2025.05.20.655037. ieee: Z. Dunajova et al., “Substrate heterogeneity promotes cancer cell dissemination through interface roughening,” bioRxiv. . ista: Dunajova Z, Tasciyan S, Majek J, Merrin J, Sahai E, Sixt MK, Hannezo EB. Substrate heterogeneity promotes cancer cell dissemination through interface roughening. bioRxiv, 10.1101/2025.05.20.655037. mla: Dunajova, Zuzana, et al. “Substrate Heterogeneity Promotes Cancer Cell Dissemination through Interface Roughening.” BioRxiv, doi:10.1101/2025.05.20.655037. short: Z. Dunajova, S. Tasciyan, J. Majek, J. Merrin, E. Sahai, M.K. Sixt, E.B. Hannezo, BioRxiv (n.d.). corr_author: '1' das_tickbox: '1' date_created: 2026-03-11T08:40:06Z date_published: 2025-09-25T00:00:00Z date_updated: 2026-07-06T12:38:17Z day: '25' ddc: - '539' - '570' department: - _id: GradSch - _id: EdHa - _id: MiSi - _id: NanoFab - _id: AnSa doi: 10.1101/2025.05.20.655037 has_accepted_license: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1101/2025.05.20.655037 month: '09' oa: 1 oa_version: Preprint project: - _id: bd91e723-d553-11ed-ba76-fe7eeb2185fd grant_number: '101071793' name: 'Pushing from within: Control of cell shape, integrity and motility by cytoskeletal pushing forces' - _id: 34d75525-11ca-11ed-8bc3-89b6307fee9d grant_number: '26360' name: Motile active matter models of migrating cells and chiral filaments publication: bioRxiv publication_status: draft related_material: record: - id: '21423' relation: dissertation_contains status: public - id: '21439' relation: research_data status: public status: public title: Substrate heterogeneity promotes cancer cell dissemination through interface roughening tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: preprint user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2025' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '20656' abstract: - lang: eng text: Phytohormone auxin and its directional transport mediate much of the remarkably plastic development of higher plants. Positive feedback between auxin signaling and transport is a prerequisite for (1) self-organizing processes, including vascular tissue formation, and (2) directional growth responses such as gravitropism. Here, we identify a mechanism by which auxin signaling directly targets PIN auxin transporters. Via the cell-surface AUXIN-BINDING PROTEIN1 (ABP1)-TRANSMEMBRANE KINASE 1 (TMK1) receptor module, auxin rapidly induces phosphorylation and thus stabilization of PIN2. Following gravistimulation, initial auxin asymmetry activates autophosphorylation of the TMK1 kinase. This induces TMK1 interaction with and phosphorylation of PIN2, stabilizing PIN2 at the lower root side, thus reinforcing asymmetric auxin flow for root bending. Upstream of TMK1 in this regulation, ABP1 acts redundantly with the root-expressed ABP1-LIKE 3 (ABL3) auxin receptor. Such positive feedback between cell-surface auxin signaling and PIN-mediated polar auxin transport is fundamental for robust root gravitropism and presumably for other self-organizing developmental phenomena. acknowledged_ssus: - _id: Bio - _id: LifeSc acknowledgement: We gratefully acknowledge Tongda Xu for experimental, material, and conceptual support. We thank William Gray for providing material, Nataliia Gnyliukh and Ema Cervenova for help with manuscript preparation, and Julia Schmid for help with cloning. We thank Dolf Weijers, Mark Roosjen, and Andre Kuhn for discussions and support with phospho-proteomic analyses. We thank the Bioimaging and Life Science facilities at the Institute of Science and Technology Austria (ISTA) for their excellent service and assistance. The research leading to these results has received funding from the European Union (ERC, CYNIPS, 101142681) and Austrian Science Fund (FWF; I 6123-B) to J.F., and Y.J. was funded by ERC no. 3363360-APPL under FP/2007-2013. L.R. was supported by the FP7-PEOPLE-2011-COFUND ISTFELLOW program (IC1023FELL01) and the European Molecular Biology Organization (EMBO) long-term postdoctoral fellowship (ALTF 985-2016). S.T. was supported by the National Natural Science Foundation of China (32321001, 32570366). The work of J.H. was supported by the project JG_2024_003 implemented within the Palacký University Young Researcher Grant. article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Lesia full_name: Rodriguez Solovey, Lesia id: 3922B506-F248-11E8-B48F-1D18A9856A87 last_name: Rodriguez Solovey orcid: 0000-0002-7244-7237 - first_name: Lukas full_name: Fiedler, Lukas id: 7c417475-8972-11ed-ae7b-8b674ca26986 last_name: Fiedler - first_name: Minxia full_name: Zou, Minxia id: 5c243f41-03f3-11ec-841c-96faf48a7ef9 last_name: Zou - first_name: Caterina full_name: Giannini, Caterina id: e3fdddd5-f6e0-11ea-865d-ca99ee6367f4 last_name: Giannini - first_name: Aline full_name: Monzer, Aline id: 2DB5D88C-D7B3-11E9-B8FD-7907E6697425 last_name: Monzer - first_name: Dmitrii full_name: Vladimirtsev, Dmitrii id: 60466724-5355-11ee-ae5a-fa55e8f99c3d last_name: Vladimirtsev - first_name: Marek full_name: Randuch, Marek id: 6ac4636d-15b2-11ec-abd3-fb8df79972ae last_name: Randuch - first_name: Yongfan full_name: Yu, Yongfan last_name: Yu - first_name: Zuzana full_name: Gelová, Zuzana id: 0AE74790-0E0B-11E9-ABC7-1ACFE5697425 last_name: Gelová orcid: 0000-0003-4783-1752 - first_name: Inge full_name: Verstraeten, Inge id: 362BF7FE-F248-11E8-B48F-1D18A9856A87 last_name: Verstraeten orcid: 0000-0001-7241-2328 - first_name: Jakub full_name: Hajny, Jakub id: 4800CC20-F248-11E8-B48F-1D18A9856A87 last_name: Hajny orcid: 0000-0003-2140-7195 - first_name: Meng full_name: Chen, Meng last_name: Chen - first_name: Shutang full_name: Tan, Shutang id: 2DE75584-F248-11E8-B48F-1D18A9856A87 last_name: Tan orcid: 0000-0002-0471-8285 - first_name: Lukas full_name: Hörmayer, Lukas id: 2EEE7A2A-F248-11E8-B48F-1D18A9856A87 last_name: Hörmayer orcid: 0000-0001-8295-2926 - first_name: Lanxin full_name: Li, Lanxin id: 367EF8FA-F248-11E8-B48F-1D18A9856A87 last_name: Li orcid: 0000-0002-5607-272X - first_name: Maria Mar full_name: Marques-Bueno, Maria Mar last_name: Marques-Bueno - first_name: Zainab full_name: Quddoos, Zainab id: 32ff3c64-04a0-11f0-a50f-d0c45bfac466 last_name: Quddoos - first_name: Gergely full_name: Molnar, Gergely id: 34F1AF46-F248-11E8-B48F-1D18A9856A87 last_name: Molnar - first_name: Ivan full_name: Kulich, Ivan id: 57a1567c-8314-11eb-9063-c9ddc3451a54 last_name: Kulich - first_name: Yvon full_name: Jaillais, Yvon last_name: Jaillais - first_name: Jiří full_name: Friml, Jiří id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 citation: ama: Rodriguez Solovey L, Fiedler L, Zou M, et al. ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism. Cell. 2025;188(22):6138-6150.e17. doi:10.1016/j.cell.2025.08.026 apa: Rodriguez Solovey, L., Fiedler, L., Zou, M., Giannini, C., Monzer, A., Vladimirtsev, D., … Friml, J. (2025). ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism. Cell. Elsevier. https://doi.org/10.1016/j.cell.2025.08.026 chicago: Rodriguez Solovey, Lesia, Lukas Fiedler, Minxia Zou, Caterina Giannini, Aline Monzer, Dmitrii Vladimirtsev, Marek Randuch, et al. “ABP1/ABL3-TMK1 Cell-Surface Auxin Signaling Targets PIN2-Mediated Auxin Fluxes for Root Gravitropism.” Cell. Elsevier, 2025. https://doi.org/10.1016/j.cell.2025.08.026. ieee: L. Rodriguez Solovey et al., “ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism,” Cell, vol. 188, no. 22. Elsevier, p. 6138–6150.e17, 2025. ista: Rodriguez Solovey L, Fiedler L, Zou M, Giannini C, Monzer A, Vladimirtsev D, Randuch M, Yu Y, Gelová Z, Verstraeten I, Hajny J, Chen M, Tan S, Hörmayer L, Li L, Marques-Bueno MM, Quddoos Z, Molnar G, Kulich I, Jaillais Y, Friml J. 2025. ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism. Cell. 188(22), 6138–6150.e17. mla: Rodriguez Solovey, Lesia, et al. “ABP1/ABL3-TMK1 Cell-Surface Auxin Signaling Targets PIN2-Mediated Auxin Fluxes for Root Gravitropism.” Cell, vol. 188, no. 22, Elsevier, 2025, p. 6138–6150.e17, doi:10.1016/j.cell.2025.08.026. short: L. Rodriguez Solovey, L. Fiedler, M. Zou, C. Giannini, A. Monzer, D. Vladimirtsev, M. Randuch, Y. Yu, Z. Gelová, I. Verstraeten, J. Hajny, M. Chen, S. Tan, L. Hörmayer, L. Li, M.M. Marques-Bueno, Z. Quddoos, G. Molnar, I. Kulich, Y. Jaillais, J. Friml, Cell 188 (2025) 6138–6150.e17. corr_author: '1' date_created: 2025-11-19T09:44:31Z date_published: 2025-10-30T00:00:00Z date_updated: 2026-07-06T12:51:13Z day: '30' ddc: - '580' department: - _id: JiFr - _id: XiFe doi: 10.1016/j.cell.2025.08.026 ec_funded: 1 external_id: isi: - '001616077900005' pmid: - '41043433' file: - access_level: open_access checksum: 8ac396a0806ad7f2e4e7a0c1eed712ce content_type: application/pdf creator: dernst date_created: 2025-11-24T10:55:18Z date_updated: 2025-11-24T10:55:18Z file_id: '20679' file_name: 2025_Cell_Rodriguez.pdf file_size: 17825465 relation: main_file success: 1 file_date_updated: 2025-11-24T10:55:18Z has_accepted_license: '1' intvolume: ' 188' isi: 1 issue: '22' language: - iso: eng month: '10' oa: 1 oa_version: Published Version page: 6138-6150.e17 pmid: 1 project: - _id: 8f347782-16d5-11f0-9cad-8c19706ee739 grant_number: '101142681' name: Cyclic nucleotides as second messengers in plants - _id: bd76d395-d553-11ed-ba76-f678c14f9033 grant_number: I06123 name: Peptide receptors for auxin canalization in Arabidopsis - _id: 26060676-B435-11E9-9278-68D0E5697425 grant_number: ALTF 985-2016 name: Cell surface receptor complexes for auxin signaling in plants - _id: 25681D80-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '291734' name: International IST Postdoc Fellowship Programme publication: Cell publication_identifier: issn: - 0092-8674 publication_status: published publisher: Elsevier quality_controlled: '1' related_material: record: - id: '19399' relation: earlier_version status: public status: public title: ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 188 year: '2025' ... --- OA_place: repository OA_type: green _id: '19399' abstract: - lang: eng text: Phytohormone auxin and its directional transport mediate much of the remarkably plastic development of higher plants. Positive feedback between auxin signaling and transport is a key prerequisite for (i) self-organizing processes including vascular tissue formation and (ii) directional growth responses such as gravitropism. Here we identify a mechanism, by which auxin signaling directly targets PIN auxin transporters. Via the cell-surface ABP1-TMK1 receptor module, auxin rapidly induces phosphorylation and thus stabilization of PIN2. Following gravistimulation, initial auxin asymmetry activates autophosphorylation of the TMK1 kinase. This induces TMK1 interaction with and phosphorylation of PIN2, stabilizing PIN2 at the lower root side, thus reinforcing asymmetric auxin flow for root bending. Upstream of TMK1 in this regulation, ABP1 acts redundantly with the root-expressed ABP1-LIKE auxin receptor ABL3. Such positive feedback between cell-surface auxin signaling and PIN-mediated polar auxin transport is fundamental for robust root gravitropism and presumably also for other self-organizing developmental phenomena. acknowledged_ssus: - _id: Bio - _id: LifeSc acknowledgement: 'We thank W. Gray for providing material; N. Gnyliukh and E. Cervenova for help with manuscript preparation; J. Schmid for help with cloning. We thank Dolf Weijers, Mark Roosjen, and Andre Kuhn for discussions and support with phospho-proteomic analyses. We thank the Bioimaging and Life Science facilities at ISTA for their excellent service and assistance. The research leading to these results has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program grant agreement No 742985 and Austrian Science Fund (FWF): I3630-775 B25 to J.F; National Natural Science Foundation of China (Grant 32130010, 31422008), start-up funds from FAFU to T.X., Y.J. was funded by ERC no. 3363360-APPL under FP/2007-2013. L.R. was supported by FP7-PEOPLE-2011-COFUND ISTFELLOW program (IC1023FELL01) and the European Molecular Biology Organization (EMBO) long-term postdoctoral fellowship (ALTF 985- 2016). S.T. was supported by the National Natural Science Foundation of China (32321001).' article_processing_charge: No author: - first_name: Lesia full_name: Rodriguez Solovey, Lesia id: 3922B506-F248-11E8-B48F-1D18A9856A87 last_name: Rodriguez Solovey orcid: 0000-0002-7244-7237 - first_name: Lukas full_name: Fiedler, Lukas id: 7c417475-8972-11ed-ae7b-8b674ca26986 last_name: Fiedler - first_name: Minxia full_name: Zou, Minxia id: 5c243f41-03f3-11ec-841c-96faf48a7ef9 last_name: Zou - first_name: Caterina full_name: Giannini, Caterina id: e3fdddd5-f6e0-11ea-865d-ca99ee6367f4 last_name: Giannini - first_name: Aline full_name: Monzer, Aline id: 2DB5D88C-D7B3-11E9-B8FD-7907E6697425 last_name: Monzer - first_name: Dmitrii full_name: Vladimirtsev, Dmitrii id: 60466724-5355-11ee-ae5a-fa55e8f99c3d last_name: Vladimirtsev - first_name: Marek full_name: Randuch, Marek id: 6ac4636d-15b2-11ec-abd3-fb8df79972ae last_name: Randuch - first_name: Yongfan full_name: Yu, Yongfan last_name: Yu - first_name: Zuzana full_name: Gelová, Zuzana id: 0AE74790-0E0B-11E9-ABC7-1ACFE5697425 last_name: Gelová orcid: 0000-0003-4783-1752 - first_name: Inge full_name: Verstraeten, Inge id: 362BF7FE-F248-11E8-B48F-1D18A9856A87 last_name: Verstraeten orcid: 0000-0001-7241-2328 - first_name: Jakub full_name: Hajny, Jakub id: 4800CC20-F248-11E8-B48F-1D18A9856A87 last_name: Hajny orcid: 0000-0003-2140-7195 - first_name: Meng full_name: Chen, Meng last_name: Chen - first_name: Shutang full_name: Tan, Shutang id: 2DE75584-F248-11E8-B48F-1D18A9856A87 last_name: Tan orcid: 0000-0002-0471-8285 - first_name: Lukas full_name: Hörmayer, Lukas id: 2EEE7A2A-F248-11E8-B48F-1D18A9856A87 last_name: Hörmayer orcid: 0000-0001-8295-2926 - first_name: Lanxin full_name: Li, Lanxin id: 367EF8FA-F248-11E8-B48F-1D18A9856A87 last_name: Li orcid: 0000-0002-5607-272X - first_name: Maria Mar full_name: Marques-Bueno, Maria Mar last_name: Marques-Bueno - first_name: Zainab full_name: Quddoos, Zainab id: 32ff3c64-04a0-11f0-a50f-d0c45bfac466 last_name: Quddoos - first_name: Gergely full_name: Molnar, Gergely id: 34F1AF46-F248-11E8-B48F-1D18A9856A87 last_name: Molnar - first_name: Tongda full_name: Xu, Tongda last_name: Xu - first_name: Ivan full_name: Kulich, Ivan id: 57a1567c-8314-11eb-9063-c9ddc3451a54 last_name: Kulich - first_name: Yvon full_name: Jaillais, Yvon last_name: Jaillais - first_name: Jiří full_name: Friml, Jiří id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 citation: ama: Rodriguez Solovey L, Fiedler L, Zou M, et al. ABP1/ABL3-TMK1 cell-surface auxin signaling directly targets PIN2-mediated auxin fluxes for root gravitropism. bioRxiv. doi:10.1101/2022.11.30.518503 apa: Rodriguez Solovey, L., Fiedler, L., Zou, M., Giannini, C., Monzer, A., Vladimirtsev, D., … Friml, J. (n.d.). ABP1/ABL3-TMK1 cell-surface auxin signaling directly targets PIN2-mediated auxin fluxes for root gravitropism. bioRxiv. https://doi.org/10.1101/2022.11.30.518503 chicago: Rodriguez Solovey, Lesia, Lukas Fiedler, Minxia Zou, Caterina Giannini, Aline Monzer, Dmitrii Vladimirtsev, Marek Randuch, et al. “ABP1/ABL3-TMK1 Cell-Surface Auxin Signaling Directly Targets PIN2-Mediated Auxin Fluxes for Root Gravitropism.” BioRxiv, n.d. https://doi.org/10.1101/2022.11.30.518503. ieee: L. Rodriguez Solovey et al., “ABP1/ABL3-TMK1 cell-surface auxin signaling directly targets PIN2-mediated auxin fluxes for root gravitropism,” bioRxiv. . ista: Rodriguez Solovey L, Fiedler L, Zou M, Giannini C, Monzer A, Vladimirtsev D, Randuch M, Yu Y, Gelová Z, Verstraeten I, Hajny J, Chen M, Tan S, Hörmayer L, Li L, Marques-Bueno MM, Quddoos Z, Molnar G, Xu T, Kulich I, Jaillais Y, Friml J. ABP1/ABL3-TMK1 cell-surface auxin signaling directly targets PIN2-mediated auxin fluxes for root gravitropism. bioRxiv, 10.1101/2022.11.30.518503. mla: Rodriguez Solovey, Lesia, et al. “ABP1/ABL3-TMK1 Cell-Surface Auxin Signaling Directly Targets PIN2-Mediated Auxin Fluxes for Root Gravitropism.” BioRxiv, doi:10.1101/2022.11.30.518503. short: L. Rodriguez Solovey, L. Fiedler, M. Zou, C. Giannini, A. Monzer, D. Vladimirtsev, M. Randuch, Y. Yu, Z. Gelová, I. Verstraeten, J. Hajny, M. Chen, S. Tan, L. Hörmayer, L. Li, M.M. Marques-Bueno, Z. Quddoos, G. Molnar, T. Xu, I. Kulich, Y. Jaillais, J. Friml, BioRxiv (n.d.). corr_author: '1' das_tickbox: '1' date_created: 2025-03-13T08:36:48Z date_published: 2025-02-20T00:00:00Z date_updated: 2026-07-06T12:51:14Z day: '20' ddc: - '580' department: - _id: JiFr - _id: XiFe doi: 10.1101/2022.11.30.518503 ec_funded: 1 language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1101/2022.11.30.518503 month: '02' oa: 1 oa_version: Published Version project: - _id: 261099A6-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '742985' name: Tracing Evolution of Auxin Transport and Polarity in Plants - _id: 26538374-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: I03630 name: Molecular mechanisms of endocytic cargo recognition in plants - _id: 25681D80-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '291734' name: International IST Postdoc Fellowship Programme - _id: 26060676-B435-11E9-9278-68D0E5697425 grant_number: ALTF 985-2016 name: Cell surface receptor complexes for auxin signaling in plants publication: bioRxiv publication_status: draft related_material: record: - id: '20656' relation: later_version status: public - id: '19395' relation: dissertation_contains status: public - id: '20364' relation: dissertation_contains status: public status: public title: ABP1/ABL3-TMK1 cell-surface auxin signaling directly targets PIN2-mediated auxin fluxes for root gravitropism type: preprint user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2025' ... --- OA_place: publisher _id: '20364' acknowledged_ssus: - _id: LifeSc - _id: Bio acknowledgement: "Plant Facility,\r\nProtein Service Facility" alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Caterina full_name: Giannini, Caterina id: e3fdddd5-f6e0-11ea-865d-ca99ee6367f4 last_name: Giannini citation: ama: Giannini C. Nuclear and cell surface auxin signaling in A. thaliana developmental transitions. 2025. doi:10.15479/AT-ISTA-20364 apa: Giannini, C. (2025). Nuclear and cell surface auxin signaling in A. thaliana developmental transitions. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20364 chicago: Giannini, Caterina. “Nuclear and Cell Surface Auxin Signaling in A. Thaliana Developmental Transitions.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20364. ieee: C. Giannini, “Nuclear and cell surface auxin signaling in A. thaliana developmental transitions,” Institute of Science and Technology Austria, 2025. ista: Giannini C. 2025. Nuclear and cell surface auxin signaling in A. thaliana developmental transitions. Institute of Science and Technology Austria. mla: Giannini, Caterina. Nuclear and Cell Surface Auxin Signaling in A. Thaliana Developmental Transitions. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20364. short: C. Giannini, Nuclear and Cell Surface Auxin Signaling in A. Thaliana Developmental Transitions, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-09-19T12:23:38Z date_published: 2025-09-19T00:00:00Z date_updated: 2026-07-06T12:51:13Z day: '19' ddc: - '580' degree_awarded: PhD department: - _id: GradSch - _id: JiFr - _id: MaLo doi: 10.15479/AT-ISTA-20364 file: - access_level: closed checksum: 536ba1701453b0b2346be14c046b2911 content_type: application/pdf creator: cgiannin date_created: 2025-09-24T14:46:34Z date_updated: 2025-09-30T14:31:29Z embargo: 2026-09-30 embargo_to: open_access file_id: '20390' file_name: 2025_Giannini_Caterina_Thesis...pdf file_size: 14278965 relation: main_file - access_level: closed checksum: 192f55262f2da2ea0a59d9c23a1b8573 content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: cgiannin date_created: 2025-09-24T14:46:35Z date_updated: 2025-09-24T14:46:35Z file_id: '20391' file_name: 2025_Giannini_Caterina_Thesis...docx file_size: 24499022 relation: source_file file_date_updated: 2025-09-30T14:31:29Z has_accepted_license: '1' keyword: - Auxin Signaling - Plant Development language: - iso: eng month: '09' oa_version: Published Version page: '151' publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '12291' relation: part_of_dissertation status: public - id: '19399' relation: part_of_dissertation status: public status: public supervisor: - first_name: Jiří full_name: Friml, Jiří id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 title: Nuclear and cell surface auxin signaling in A. thaliana developmental transitions type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: publisher _id: '20441' abstract: - lang: eng text: "Epithelial spreading plays a pivotal role in the development of organisms especially those\r\nsuch as zebrafish which require the epithelial enveloping layer (EVL) to spread to cover the\r\nsubstantial yolk surface during gastrulation. Epiboly requires the transition of the epithelium\r\nwith cuboidal cells to form a thin, flat squamous epithelial sheet. During this transition, the\r\ncells show tissue-scale mechanosensation with mechanisms such as direct mechanical control\r\nover the axis of cell division.\r\nCytoskeletal intermediate filaments play a crucial role in vertebrate cells, not only facilitating\r\nmechanical stability but also helping facilitate the mechanosensitive response of the cell.\r\nMechanosenstivity displayed by intermediate filaments is due not just to their interesting\r\nphysical properties but also to their interactions with other cytoskeletal elements such as actin\r\nand microtubules. Keratin is the predominant intermediate filament expressed in the EVL.\r\nIt expresses concomitantly with the gastrulation movements of the developing embryo. Our\r\nwork focuses on understanding the role and dynamics of the keratin cytoskeletal network in\r\nmodulating the physical aspects of EVL spreading. We demonstrated with the combination of\r\nphysical characterisation and manipulations of the EVL, utilising a variety of biophysical tools\r\nand microscopy, the mechanistic role of keratin in tissue spreading.\r\nGenerating novel genetic morphants and mutants, we probe the effect that the loss of the\r\nkeratin network has on the physiology of the epithelium and the developing embryo. We\r\nshow that the changing organisation of the keratin network is important for changing EVL\r\nphysical properties as the stress imposed on the EVL increases during epiboly. By modelling\r\nthe epithelium, we study how the mechanical heterogeneity in an epithelium can feed back into\r\na mechanical loop to the maturation of the keratin network and hence affect the mechanics\r\nof the epithelium. However, unlike what would be predicted by the effect of intermediate\r\nfilaments in acting as a security belt and increasing the resistance of the epithelium, we observe\r\nthat loss of keratin leads to a delay in the EVL movement. Using both local aspirations of the\r\nYSL and EVL ablations, we demonstrate the mechanistic facilitation of actin mechanosensation\r\nin a keratin-dependent manner.\r\nFurthermore, using chemical inhibitors of microtubule polymerisation, we provide insight into\r\nthe mechanisms underlying the organisation and distribution of keratin. Interestingly, the\r\nphenotype observed upon this loss of microtubules shows that keratins interact with the nucleus\r\nthrough microtubular interactions. Together with these diverse observations, we describe\r\nthe mechanosensory feedback between resilience and that is critical for uniform and robust\r\nspreading of the epithelium." acknowledged_ssus: - _id: Bio - _id: LifeSc acknowledgement: "I would also like to thank the LSF and Cryo facility at ISTA, which have been helpful in my\r\nexperiments. I would also like to acknowledge FWF, grant DOI 10.55776/PAT5044023 and JKU Nanocell grant DOI \r\n10.55776/W1250 for providing funding for my PhD research. EMBO and FWF for providing funding for travel grants to attend conferences." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Suyash full_name: Naik, Suyash id: 2C0B105C-F248-11E8-B48F-1D18A9856A87 last_name: Naik orcid: 0000-0001-8421-5508 citation: ama: Naik S. Keratins act as global coordinators of tissue spreading through mechanosensitive feedback. 2025. doi:10.15479/AT-ISTA-20441 apa: Naik, S. (2025). Keratins act as global coordinators of tissue spreading through mechanosensitive feedback. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20441 chicago: Naik, Suyash. “Keratins Act as Global Coordinators of Tissue Spreading through Mechanosensitive Feedback.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20441. ieee: S. Naik, “Keratins act as global coordinators of tissue spreading through mechanosensitive feedback,” Institute of Science and Technology Austria, 2025. ista: Naik S. 2025. Keratins act as global coordinators of tissue spreading through mechanosensitive feedback. Institute of Science and Technology Austria. mla: Naik, Suyash. Keratins Act as Global Coordinators of Tissue Spreading through Mechanosensitive Feedback. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20441. short: S. Naik, Keratins Act as Global Coordinators of Tissue Spreading through Mechanosensitive Feedback, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-10-10T14:58:30Z date_published: 2025-10-12T00:00:00Z date_updated: 2026-07-06T12:51:41Z day: '12' ddc: - '596' - '597' - '532' degree_awarded: PhD department: - _id: GradSch - _id: CaHe - _id: EdHa doi: 10.15479/AT-ISTA-20441 file: - access_level: open_access checksum: 2892f04d4a5c18677871c3e06ac1244a content_type: application/pdf creator: snaik date_created: 2025-10-28T13:10:08Z date_updated: 2025-10-28T13:10:08Z file_id: '20567' file_name: Thesis_PDFA_.pdf file_size: 6846189 relation: main_file success: 1 - access_level: open_access checksum: 15934d4465cd0e9b7c32678da9a33a2f content_type: application/zip creator: snaik date_created: 2025-10-28T13:10:26Z date_updated: 2025-10-28T13:10:26Z file_id: '20568' file_name: Thesis.zip file_size: 8839300 relation: source_file file_date_updated: 2025-10-28T13:10:26Z has_accepted_license: '1' language: - iso: eng month: '10' oa: 1 oa_version: Published Version page: '105' project: - _id: 8f060199-16d5-11f0-9cad-f3253b266c46 grant_number: PAT 5044023 name: Keratins in epithelial tissue spreading - _id: 25AA5F24-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: W 1250-B20 name: Nano-Analytics of Cellular Systems publication_identifier: isbn: - 978-3-99078-069-5 issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '20465' relation: part_of_dissertation status: public status: public supervisor: - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 - first_name: Edouard B full_name: Hannezo, Edouard B id: 3A9DB764-F248-11E8-B48F-1D18A9856A87 last_name: Hannezo orcid: 0000-0001-6005-1561 title: Keratins act as global coordinators of tissue spreading through mechanosensitive feedback tmp: image: /images/cc_by_sa.png legal_code_url: https://creativecommons.org/licenses/by-sa/4.0/legalcode name: Creative Commons Attribution-ShareAlike 4.0 International Public License (CC BY-SA 4.0) short: CC BY-SA (4.0) type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: publisher _id: '19395' abstract: - lang: eng text: "Plant growth and development rely significantly on phytohormones, with auxin serving as a master regulator, orchestrating processes from embryogenesis to organogenesis, vascular patterning, and environmental adaptation. Since its conceptual proposition by Charles Darwin in 1880 as an endogenous chemical signal influencing phototropism in grass, auxin has captivated scientists seeking to understand how such a small molecule exerts a profound influence on plant development.\r\nOne particularly fascinating aspect of auxin function is its ability to self-organize its transport. Through a feedback mechanism between auxin perception and directional transport—primarily mediated by PIN auxin transporters—auxin establishes narrow transport channels. This phenomenon, known as auxin canalization, is fundamental to vascular formation, regeneration, and other key developmental processes. Despite advances in our understanding, driven by experimental studies and computational models, auxin canalization remains an enigma, with many unanswered questions.\r\nLike other hormones, auxin functions through intricate signaling pathways. It operates through at least two distinct signaling mechanisms: the well-characterized canonical pathway and the less understood non-canonical pathway. While significant progress has been made in elucidating the canonical pathway, the non-canonical mechanisms remain less defined and require further investigation.\r\nIn this study, we revisit the non-canonical auxin signaling pathway mediated by the cell-surface complex Auxin Binding Protein 1-Transmembrane Kinase 1 (ABP1-TMK1), with a particular focus on its downstream phosphorylation events. We reveal that this auxin-mediated phosphorylation is conserved across the green lineage, underscoring its fundamental role in plant development. We explore key phosphorylation targets, particularly PIN2, which is essential for root gravitropism. To further understand TMK1’s role in diverse developmental processes, we identified and investigated its interactors as potential co-receptors or regulatory components within its signaling network.\r\nGiven the previously established role of ABP1-TMK1 in auxin canalization, we sought to further investigate this process and identified several TMK1 interactors also involved in this intricate mechanism.\r\nThese findings provide new insights into the complex regulation of auxin canalization, highlighting a broader and more interconnected signaling framework than previously understood." acknowledged_ssus: - _id: LifeSc - _id: Bio acknowledgement: I would like to acknowledge the facilities at ISTA, particularly LSF, IOF, and, of course, the plant facility, for providing the necessary resources for my research. alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Aline full_name: Monzer, Aline id: 2DB5D88C-D7B3-11E9-B8FD-7907E6697425 last_name: Monzer citation: ama: 'Monzer A. Cell-Surface Auxin Signaling: Linking molecular pathways to plant development. 2025. doi:10.15479/AT-ISTA-19395' apa: 'Monzer, A. (2025). Cell-Surface Auxin Signaling: Linking molecular pathways to plant development. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-19395' chicago: 'Monzer, Aline. “Cell-Surface Auxin Signaling: Linking Molecular Pathways to Plant Development.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-19395.' ieee: 'A. Monzer, “Cell-Surface Auxin Signaling: Linking molecular pathways to plant development,” Institute of Science and Technology Austria, 2025.' ista: 'Monzer A. 2025. Cell-Surface Auxin Signaling: Linking molecular pathways to plant development. Institute of Science and Technology Austria.' mla: 'Monzer, Aline. Cell-Surface Auxin Signaling: Linking Molecular Pathways to Plant Development. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-19395.' short: 'A. Monzer, Cell-Surface Auxin Signaling: Linking Molecular Pathways to Plant Development, Institute of Science and Technology Austria, 2025.' corr_author: '1' date_created: 2025-03-12T14:25:42Z date_published: 2025-03-13T00:00:00Z date_updated: 2026-07-06T12:52:09Z day: '13' ddc: - '580' degree_awarded: PhD department: - _id: GradSch - _id: JiFr doi: 10.15479/AT-ISTA-19395 file: - access_level: open_access checksum: 9a3dd03bb4ec6b9907a325c3c4e8a1d7 content_type: application/pdf creator: amonzer date_created: 2025-03-12T14:14:49Z date_updated: 2025-03-12T14:14:49Z file_id: '19396' file_name: Final Thesis Aline Monzer.pdf file_size: 13119670 relation: main_file success: 1 - access_level: closed checksum: a353ce1ee2eabce37bca35499e76dbf1 content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: amonzer date_created: 2025-03-12T14:15:19Z date_updated: 2025-04-01T07:55:27Z file_id: '19397' file_name: Thesis Aline.docx file_size: 13774837 relation: source_file file_date_updated: 2025-04-01T07:55:27Z has_accepted_license: '1' language: - iso: eng month: '03' oa: 1 oa_version: Published Version page: '160' publication_identifier: eisbn: - 978-3-99078-054-1 eissn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '12291' relation: part_of_dissertation status: public - id: '14826' relation: part_of_dissertation status: public - id: '19399' relation: part_of_dissertation status: public - id: '19398' relation: part_of_dissertation status: public status: public supervisor: - first_name: Jiří full_name: Friml, Jiří id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 title: 'Cell-Surface Auxin Signaling: Linking molecular pathways to plant development' type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: repository OA_type: green _id: '19398' abstract: - lang: eng text: Receptor-like kinases (RLKs), particularly the Transmembrane Kinase (TMK) family, play essential roles in signaling and development, with TMKs being key components of auxin perception and downstream phosphorylation events. While TMKs’ involvement in auxin canalization, a process essential for vasculature formation and regeneration, has been established, nonetheless, the additional signaling and regulatory partners remain poorly understood. In this study, we identify and characterize seven leucine-rich repeat RLKs (TINT1–TINT7) as novel interactors of TMK1, revealing their diverse evolutionary, structural, and functional characteristics. Our results show that TINTs interact with TMK1 and highlight their roles in regulating various developmental processes. Majority of TINTs contributes, together with TMK1, to auxin canalization, with TINT5 linking TMK1 to other canalization component CAMEL. Beyond canalization, we also establish the role of TINT-TMK1 interactions in processes such as stomatal movement and the hypocotyl’s gravitropic response. These findings suggest that TINTs, through their interaction with TMK1, are integral components of various signaling networks, contributing to both auxin canalization and broader plant development. acknowledged_ssus: - _id: Bio - _id: LifeSc acknowledgement: We deeply appreciate M. Wrzaczek’s constructive input and insightful discussions, which significantly enriched this work. We thank L. Fiedler for helping with the heat map and for the discussions. We also thank the facilities at ISTA, the imaging and optics (IOF) and Lab Support (LSF) facilities for their service and assistance. article_processing_charge: No author: - first_name: Aline full_name: Monzer, Aline id: 2DB5D88C-D7B3-11E9-B8FD-7907E6697425 last_name: Monzer - first_name: Ewa full_name: Mazur, Ewa last_name: Mazur - first_name: Lesia full_name: Rodriguez Solovey, Lesia id: 3922B506-F248-11E8-B48F-1D18A9856A87 last_name: Rodriguez Solovey orcid: 0000-0002-7244-7237 - first_name: Michelle C full_name: Gallei, Michelle C id: 35A03822-F248-11E8-B48F-1D18A9856A87 last_name: Gallei orcid: 0000-0003-1286-7368 - first_name: Minxia full_name: Zou, Minxia id: 5c243f41-03f3-11ec-841c-96faf48a7ef9 last_name: Zou - first_name: Michael full_name: Smejkal, Michael id: 79a5a1be-04a3-11f0-ba18-a1730e0b58e9 last_name: Smejkal - first_name: Ema full_name: Cervenova, Ema id: 9f185b95-04a3-11f0-8245-f5e32eeb470f last_name: Cervenova - first_name: Jiří full_name: Friml, Jiří id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 citation: ama: Monzer A, Mazur E, Rodriguez Solovey L, et al. TMK interacting network of receptor like kinases for auxin canalization and beyond. bioRxiv. doi:10.1101/2025.02.28.640727 apa: Monzer, A., Mazur, E., Rodriguez Solovey, L., Gallei, M. C., Zou, M., Smejkal, M., … Friml, J. (n.d.). TMK interacting network of receptor like kinases for auxin canalization and beyond. bioRxiv. https://doi.org/10.1101/2025.02.28.640727 chicago: Monzer, Aline, Ewa Mazur, Lesia Rodriguez Solovey, Michelle C Gallei, Minxia Zou, Michael Smejkal, Ema Cervenova, and Jiří Friml. “TMK Interacting Network of Receptor like Kinases for Auxin Canalization and Beyond.” BioRxiv, n.d. https://doi.org/10.1101/2025.02.28.640727. ieee: A. Monzer et al., “TMK interacting network of receptor like kinases for auxin canalization and beyond,” bioRxiv. . ista: Monzer A, Mazur E, Rodriguez Solovey L, Gallei MC, Zou M, Smejkal M, Cervenova E, Friml J. TMK interacting network of receptor like kinases for auxin canalization and beyond. bioRxiv, 10.1101/2025.02.28.640727. mla: Monzer, Aline, et al. “TMK Interacting Network of Receptor like Kinases for Auxin Canalization and Beyond.” BioRxiv, doi:10.1101/2025.02.28.640727. short: A. Monzer, E. Mazur, L. Rodriguez Solovey, M.C. Gallei, M. Zou, M. Smejkal, E. Cervenova, J. Friml, BioRxiv (n.d.). corr_author: '1' das_tickbox: '1' date_created: 2025-03-12T14:28:53Z date_published: 2025-03-02T00:00:00Z date_updated: 2026-07-06T12:52:09Z day: '02' ddc: - '580' department: - _id: GradSch - _id: JiFr - _id: EvBe doi: 10.1101/2025.02.28.640727 has_accepted_license: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1101/2025.02.28.640727 month: '03' oa: 1 oa_version: Published Version publication: bioRxiv publication_status: draft related_material: record: - id: '19395' relation: dissertation_contains status: public status: public title: TMK interacting network of receptor like kinases for auxin canalization and beyond tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: preprint user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2025' ... --- OA_place: publisher _id: '19478' acknowledged_ssus: - _id: Bio - _id: LifeSc acknowledgement: "This project was funded by the European Research Council Advanced Grant (ETAP-742985),\r\nEuropean Research Council (ERC; 101142681 CYNIPS), Austrian Science Fund (FWF; P\r\n37051-B)." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Huihuang full_name: Chen, Huihuang id: 83c96512-15b2-11ec-abd3-b7eede36184f last_name: Chen citation: ama: Chen H. The cAMP second messenger in auxin signalling. 2025. doi:10.15479/AT-ISTA-19478 apa: Chen, H. (2025). The cAMP second messenger in auxin signalling. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-19478 chicago: Chen, Huihuang. “The CAMP Second Messenger in Auxin Signalling.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-19478. ieee: H. Chen, “The cAMP second messenger in auxin signalling,” Institute of Science and Technology Austria, 2025. ista: Chen H. 2025. The cAMP second messenger in auxin signalling. Institute of Science and Technology Austria. mla: Chen, Huihuang. The CAMP Second Messenger in Auxin Signalling. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-19478. short: H. Chen, The CAMP Second Messenger in Auxin Signalling, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-04-04T07:48:24Z date_published: 2025-04-04T00:00:00Z date_updated: 2026-07-06T12:58:58Z day: '04' ddc: - '580' degree_awarded: PhD department: - _id: GradSch - _id: JiFr doi: 10.15479/AT-ISTA-19478 ec_funded: 1 file: - access_level: closed checksum: b154973663a1bba505683faab7ae5ead content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: hchen date_created: 2025-04-08T08:00:07Z date_updated: 2025-04-08T08:22:37Z file_id: '19526' file_name: Thesis_0403_Huihuang.docx file_size: 16344814 relation: source_file - access_level: closed checksum: 0099565f024388830c125ec17375c1a0 content_type: application/pdf creator: hchen date_created: 2025-04-08T08:00:06Z date_updated: 2025-04-09T13:53:38Z embargo: 2026-10-08 embargo_to: local file_id: '19527' file_name: Thesis_0406_PDFA_Huihuang_1.pdf file_size: 8482147 relation: main_file file_date_updated: 2025-04-09T13:53:38Z has_accepted_license: '1' language: - iso: eng month: '04' oa_version: Published Version page: '118' project: - _id: 261099A6-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '742985' name: Tracing Evolution of Auxin Transport and Polarity in Plants - _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6 grant_number: P37051 name: Guanylate cyclase activity of TIR1/AFBs auxin receptors - _id: 8f347782-16d5-11f0-9cad-8c19706ee739 grant_number: '101142681' name: Cyclic nucleotides as second messengers in plants publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '19421' relation: part_of_dissertation status: public - id: '13212' relation: part_of_dissertation status: public status: public supervisor: - first_name: Jiří full_name: Friml, Jiří id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 title: The cAMP second messenger in auxin signalling type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: publisher _id: '20920' abstract: - lang: eng text: "Verifiable Delay Functions (VDFs) introduced by Boneh et al. (CRYPTO'18) are functions that require a prescribed number of sequential steps T to evaluate, yet their output can be verified in time much faster than T. Since their introduction, VDFs have gained a lot of attention due to their applications in blockchain protocols, randomness beacons, timestamping and deniability. This thesis explores the theory and applications of VDFs, focusing on enhancing their soundness, efficiency and practicality.\r\n\r\nThe only practical VDFs known to date are based on repeated squaring in hidden order groups. Consider the function VDF(x,T)=x^(2^T).\r\nThe iterated squaring assumption states that, for a random group element x, the result of VDF cannot be computed significantly faster than performing T sequential squarings if the group order is unknown. To make the result verifiable a prover can compute a proof of exponentiation (PoE) \\pi. Given \\pi, the output of VDF can be verified in time much less than T.\r\n\r\nWe first present new constructions of statistically sound proofs of exponentiation, which are an important building block in the construction of SNARKs (Succinct Non-Interactive Argument of Knowledge). Statistical soundness means that the proofs remain secure against computationally unbounded adversaries, in particular, it remains secure even when the group order is known. We thereby address limitations in previous PoE protocols which either required (non-standard) hardness assumptions or a lot of parallel repetitions. Our construction significantly reduces the proof size of statistically sound PoEs that allow for a structured exponent, which leads to better efficiency of SNARKs and other applications.\r\n\r\nSecondly, we introduce improved batching techniques for PoEs, which allow multiple proofs to be aggregated and verified with minimal overhead. These protocols optimize communication and computation complexity in large-scale blockchain environments and enable scalable remote benchmarking of parallel computation resources.\r\n\r\nWe then construct VDFs with enhanced properties such as zero-knowledge and watermarkability. It was shown by Arun, Bonneau and Clark (ASIACRYPT'22) that these features enable new cryptographic primitives called short-lived proofs and signatures. The validity of such proofs and signatures expires after a predefined amount of time T, i.e., they are deniable after time T. Our constructions improve upon the constructions by Arun, Bonneau and Clark in several dimensions (faster forging times, arguably weaker assumptions).\r\n\r\nFinally, we apply PoEs in the realm of primality testing, providing cryptographically sound proofs of non-primality for large Proth numbers. This work gives a surprising application of VDFs in the area of computational number theory.\r\n\r\nTogether, our contributions advance both the theoretical foundations and the real-world usability of VDFs in general and in particular of PoEs, making them more adaptable and secure for current and emerging cryptographic applications." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Charlotte full_name: Hoffmann, Charlotte id: 0f78d746-dc7d-11ea-9b2f-83f92091afe7 last_name: Hoffmann orcid: 0000-0003-2027-5549 citation: ama: Hoffmann C. Theory and applications of verifiable delay functions. 2025. doi:10.15479/AT-ISTA-20920 apa: Hoffmann, C. (2025). Theory and applications of verifiable delay functions. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20920 chicago: Hoffmann, Charlotte. “Theory and Applications of Verifiable Delay Functions.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20920. ieee: C. Hoffmann, “Theory and applications of verifiable delay functions,” Institute of Science and Technology Austria, 2025. ista: Hoffmann C. 2025. Theory and applications of verifiable delay functions. Institute of Science and Technology Austria. mla: Hoffmann, Charlotte. Theory and Applications of Verifiable Delay Functions. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20920. short: C. Hoffmann, Theory and Applications of Verifiable Delay Functions, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2026-01-02T10:46:47Z date_published: 2025-12-31T00:00:00Z date_updated: 2026-07-06T13:15:27Z day: '31' ddc: - '004' degree_awarded: PhD department: - _id: GradSch - _id: KrPi doi: 10.15479/AT-ISTA-20920 file: - access_level: closed checksum: 8a099fbf54963bd0be38f7ce73658682 content_type: application/x-zip-compressed creator: choffman date_created: 2026-01-02T10:39:16Z date_updated: 2026-01-02T10:39:16Z file_id: '20921' file_name: 2025_Hoffmann_Charlotte_Source.zip file_size: 8355494 relation: source_file - access_level: open_access checksum: 9521c07bfb2bb5b14a49c09fcfc96474 content_type: application/pdf creator: choffman date_created: 2026-01-02T10:39:26Z date_updated: 2026-01-02T10:39:26Z file_id: '20922' file_name: 2025_Hoffmann_Charlotte_Thesis.pdf file_size: 2258804 relation: main_file success: 1 file_date_updated: 2026-01-02T10:39:26Z has_accepted_license: '1' language: - iso: eng month: '12' oa: 1 oa_version: Published Version page: '116' publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '13143' relation: part_of_dissertation status: public - id: '12176' relation: part_of_dissertation status: public - id: '20556' relation: earlier_version status: public - id: '19778' relation: part_of_dissertation status: public - id: '20701' relation: part_of_dissertation status: public status: public supervisor: - first_name: Krzysztof Z full_name: Pietrzak, Krzysztof Z id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87 last_name: Pietrzak orcid: 0000-0002-9139-1654 title: Theory and applications of verifiable delay functions tmp: image: /images/cc_by_nc_sa.png legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) short: CC BY-NC-SA (4.0) type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: publisher _id: '20556' abstract: - lang: eng text: "Verifiable Delay Functions (VDFs) introduced by Boneh et al. (CRYPTO'18) are functions that require a prescribed number of sequential steps T to evaluate, yet their output can be verified in time much faster than T. Since their introduction, VDFs have gained a lot of attention due to their applications in blockchain protocols, randomness beacons, timestamping and deniability. This thesis explores the theory and applications of VDFs, focusing on enhancing their soundness, efficiency and practicality.\r\n\r\nThe only practical VDFs known to date are based on repeated squaring in hidden order groups. Consider the function VDF(x,T)=x^(2^T).\r\nThe iterated squaring assumption states that, for a random group element x, the result of VDF cannot be computed significantly faster than performing T sequential squarings if the group order is unknown. To make the result verifiable a prover can compute a proof of exponentiation (PoE) \\pi. Given \\pi, the output of VDF can be verified in time much less than T.\r\n\r\nWe first present new constructions of statistically sound proofs of exponentiation, which are an important building block in the construction of SNARKs (Succinct Non-Interactive Argument of Knowledge). Statistical soundness means that the proofs remain secure against computationally unbounded adversaries, in particular, it remains secure even when the group order is known. We thereby address limitations in previous PoE protocols which either required (non-standard) hardness assumptions or a lot of parallel repetitions. Our construction significantly reduces the proof size of statistically sound PoEs that allow for a structured exponent, which leads to better efficiency of SNARKs and other applications.\r\n\r\nSecondly, we introduce improved batching techniques for PoEs, which allow multiple proofs to be aggregated and verified with minimal overhead. These protocols optimize communication and computation complexity in large-scale blockchain environments and enable scalable remote benchmarking of parallel computation resources.\r\n\r\nWe then construct VDFs with enhanced properties such as zero-knowledge and watermarkability. It was shown by Arun, Bonneau and Clark (ASIACRYPT'22) that these features enable new cryptographic primitives called short-lived proofs and signatures. The validity of such proofs and signatures expires after a predefined amount of time T, i.e., they are deniable after time T. Our constructions improve upon the constructions by Arun, Bonneau and Clark in several dimensions (faster forging times, arguably weaker assumptions).\r\n\r\nFinally, we apply PoEs in the realm of primality testing, providing cryptographically sound proofs of non-primality for large Proth numbers. This work gives a surprising application of VDFs in the area of computational number theory.\r\n\r\nTogether, our contributions advance both the theoretical foundations and the real-world usability of VDFs in general and in particular of PoEs, making them more adaptable and secure for current and emerging cryptographic applications." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Charlotte full_name: Hoffmann, Charlotte id: 0f78d746-dc7d-11ea-9b2f-83f92091afe7 last_name: Hoffmann orcid: 0000-0003-2027-5549 citation: ama: Hoffmann C. Theory and applications of verifiable delay functions. 2025. doi:10.15479/AT-ISTA-20556 apa: Hoffmann, C. (2025). Theory and applications of verifiable delay functions. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20556 chicago: Hoffmann, Charlotte. “Theory and Applications of Verifiable Delay Functions.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20556. ieee: C. Hoffmann, “Theory and applications of verifiable delay functions,” Institute of Science and Technology Austria, 2025. ista: Hoffmann C. 2025. Theory and applications of verifiable delay functions. Institute of Science and Technology Austria. mla: Hoffmann, Charlotte. Theory and Applications of Verifiable Delay Functions. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20556. short: C. Hoffmann, Theory and Applications of Verifiable Delay Functions, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-10-27T14:16:56Z date_published: 2025-10-31T00:00:00Z date_updated: 2026-07-06T13:15:27Z day: '31' ddc: - '004' degree_awarded: PhD department: - _id: GradSch - _id: KrPi doi: 10.15479/AT-ISTA-20556 file: - access_level: closed checksum: 1fffa4e2c33dd0b9f883d615504a2858 content_type: application/pdf creator: choffman date_created: 2025-10-28T14:33:03Z date_updated: 2026-01-08T14:11:39Z file_id: '20573' file_name: 2025_Hoffmann_Charlotte_Thesis.pdf file_size: 2259304 relation: main_file - access_level: closed checksum: 076ea98a1f0a86c3bbc990b6b9460dc2 content_type: application/x-zip-compressed creator: choffman date_created: 2025-10-28T14:35:06Z date_updated: 2025-11-11T09:34:54Z file_id: '20574' file_name: 2025_Hoffmann_Charlotte_Source.zip file_size: 9987633 relation: source_file file_date_updated: 2026-01-08T14:11:39Z has_accepted_license: '1' language: - iso: eng month: '10' oa_version: Published Version page: '116' publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '13143' relation: part_of_dissertation status: public - id: '12176' relation: part_of_dissertation status: public - id: '20920' relation: later_version status: public - id: '19778' relation: part_of_dissertation status: public - id: '20701' relation: part_of_dissertation status: public status: public supervisor: - first_name: Krzysztof Z full_name: Pietrzak, Krzysztof Z id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87 last_name: Pietrzak orcid: 0000-0002-9139-1654 title: Theory and applications of verifiable delay functions tmp: image: /images/cc_by_nc_sa.png legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) short: CC BY-NC-SA (4.0) type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: repository OA_type: green _id: '10011' abstract: - lang: eng text: We propose a new weak solution concept for (two-phase) mean curvature flow which enjoys both (unconditional) existence and (weak-strong) uniqueness properties. These solutions are evolving varifolds, just as in Brakke's formulation, but are coupled to the phase volumes by a simple transport equation. First, we show that, in the exact same setup as in Ilmanen's proof [J. Differential Geom. 38, 417-461, (1993)], any limit point of solutions to the Allen-Cahn equation is a varifold solution in our sense. Second, we prove that any calibrated flow in the sense of Fischer et al. [arXiv:2003.05478] - and hence any classical solution to mean curvature flow-is unique in the class of our new varifold solutions. This is in sharp contrast to the case of Brakke flows, which a priori may disappear at any given time and are therefore fatally non-unique. Finally, we propose an extension of the solution concept to the multi-phase case which is at least guaranteed to satisfy a weak-strong uniqueness principle. acknowledgement: This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 948819), and from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC-2047/1 – 390685813. The content of this paper was developed and parts of it were written during a visit of the first author to the Hausdorff Center of Mathematics (HCM), University of Bonn. The hospitality and the support of HCM are gratefully acknowledged. article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Sebastian full_name: Hensel, Sebastian id: 4D23B7DA-F248-11E8-B48F-1D18A9856A87 last_name: Hensel orcid: 0000-0001-7252-8072 - first_name: Tim full_name: Laux, Tim last_name: Laux citation: ama: 'Hensel S, Laux T. A new varifold solution concept for mean curvature flow: Convergence of  the Allen-Cahn equation and weak-strong uniqueness. Journal of Differential Geometry. 2025;130:209-268. doi:10.4310/jdg/1747065796' apa: 'Hensel, S., & Laux, T. (2025). A new varifold solution concept for mean curvature flow: Convergence of  the Allen-Cahn equation and weak-strong uniqueness. Journal of Differential Geometry. International Press of Boston. https://doi.org/10.4310/jdg/1747065796' chicago: 'Hensel, Sebastian, and Tim Laux. “A New Varifold Solution Concept for Mean Curvature Flow: Convergence of  the Allen-Cahn Equation and Weak-Strong Uniqueness.” Journal of Differential Geometry. International Press of Boston, 2025. https://doi.org/10.4310/jdg/1747065796.' ieee: 'S. Hensel and T. Laux, “A new varifold solution concept for mean curvature flow: Convergence of  the Allen-Cahn equation and weak-strong uniqueness,” Journal of Differential Geometry, vol. 130. International Press of Boston, pp. 209–268, 2025.' ista: 'Hensel S, Laux T. 2025. A new varifold solution concept for mean curvature flow: Convergence of  the Allen-Cahn equation and weak-strong uniqueness. Journal of Differential Geometry. 130, 209–268.' mla: 'Hensel, Sebastian, and Tim Laux. “A New Varifold Solution Concept for Mean Curvature Flow: Convergence of  the Allen-Cahn Equation and Weak-Strong Uniqueness.” Journal of Differential Geometry, vol. 130, International Press of Boston, 2025, pp. 209–68, doi:10.4310/jdg/1747065796.' short: S. Hensel, T. Laux, Journal of Differential Geometry 130 (2025) 209–268. corr_author: '1' das_tickbox: '1' date_created: 2021-09-13T12:17:10Z date_published: 2025-05-01T00:00:00Z date_updated: 2026-07-06T13:37:21Z day: '01' department: - _id: JuFi doi: 10.4310/jdg/1747065796 ec_funded: 1 external_id: arxiv: - '2109.04233' intvolume: ' 130' keyword: - Mean curvature flow - gradient flows - varifolds - weak solutions - weak-strong uniqueness - calibrated geometry - gradient-flow calibrations language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/2109.04233 month: '05' oa: 1 oa_version: Preprint page: 209-268 project: - _id: 0aa76401-070f-11eb-9043-b5bb049fa26d call_identifier: H2020 grant_number: '948819' name: Bridging Scales in Random Materials publication: Journal of Differential Geometry publication_identifier: eissn: - 1945-743X issn: - 0022-040X publication_status: published publisher: International Press of Boston quality_controlled: '1' scopus_import: '1' status: public title: 'A new varifold solution concept for mean curvature flow: Convergence of the Allen-Cahn equation and weak-strong uniqueness' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 130 year: '2025' ... --- OA_place: publisher OA_type: diamond _id: '20668' abstract: - lang: eng text: "The Message Layer Security (MLS) protocol has recently been standardized by the IETF. MLS is a scalable secure group messaging protocol expected to run more efficiently compared to the Signal protocol at scale, while offering a similar level of strong security. Even though MLS has undergone extensive examination by researchers, the majority of the works have focused on confidentiality.\r\n\r\nIn this work, we focus on the authenticity of the application messages exchanged in MLS. Currently, MLS authenticates every application message with an EdDSA signature and while manageable, the overhead is greatly amplified in the post-quantum setting as the NIST-recommended Dilithium signature results in a 40x increase in size. We view this as an invitation to explore new authentication modes that can be used instead. We start by taking a systematic view on how application messages are authenticated in MLS and categorize authenticity into four different security notions. We then propose several authentication modes, offering a range of different efficiency and security profiles. For instance, in one of our modes, COSMOS++, we replace signatures with one-time tokens and a MAC tag, offering roughly a 75x savings in the post-quantum communication overhead. While this comes at the cost of weakening security compared to the authentication mode used by MLS, the lower communication overhead seems to make it a worthwhile trade-off with security." acknowledgement: This research was partially supported by JST CREST JPMJCR22M1, Japan and funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No.665385. article_processing_charge: No author: - first_name: Keitaro full_name: Hashimoto, Keitaro last_name: Hashimoto - first_name: Shuichi full_name: Katsumata, Shuichi last_name: Katsumata - first_name: Guillermo full_name: Pascual Perez, Guillermo id: 2D7ABD02-F248-11E8-B48F-1D18A9856A87 last_name: Pascual Perez orcid: 0000-0001-8630-415X citation: ama: 'Hashimoto K, Katsumata S, Pascual Perez G. Exploring how to authenticate application messages in MLS: More efficient, post-quantum, and anonymous blocklistable. In: 34th Usenix Security Symposium. Usenix Association; 2025:6699-6716.' apa: 'Hashimoto, K., Katsumata, S., & Pascual Perez, G. (2025). Exploring how to authenticate application messages in MLS: More efficient, post-quantum, and anonymous blocklistable. In 34th Usenix Security Symposium (pp. 6699–6716). Seattle, WA, USA: Usenix Association.' chicago: 'Hashimoto, Keitaro, Shuichi Katsumata, and Guillermo Pascual Perez. “Exploring How to Authenticate Application Messages in MLS: More Efficient, Post-Quantum, and Anonymous Blocklistable.” In 34th Usenix Security Symposium, 6699–6716. Usenix Association, 2025.' ieee: 'K. Hashimoto, S. Katsumata, and G. Pascual Perez, “Exploring how to authenticate application messages in MLS: More efficient, post-quantum, and anonymous blocklistable,” in 34th Usenix Security Symposium, Seattle, WA, USA, 2025, pp. 6699–6716.' ista: 'Hashimoto K, Katsumata S, Pascual Perez G. 2025. Exploring how to authenticate application messages in MLS: More efficient, post-quantum, and anonymous blocklistable. 34th Usenix Security Symposium. USENIX: Security Symposium, 6699–6716.' mla: 'Hashimoto, Keitaro, et al. “Exploring How to Authenticate Application Messages in MLS: More Efficient, Post-Quantum, and Anonymous Blocklistable.” 34th Usenix Security Symposium, Usenix Association, 2025, pp. 6699–716.' short: K. Hashimoto, S. Katsumata, G. Pascual Perez, in:, 34th Usenix Security Symposium, Usenix Association, 2025, pp. 6699–6716. conference: end_date: 2025-08-15 location: Seattle, WA, USA name: 'USENIX: Security Symposium' start_date: 2025-08-13 corr_author: '1' cryptoeprintid: 1 das_tickbox: '1' date_created: 2025-11-23T23:01:40Z date_published: 2025-01-01T00:00:00Z date_updated: 2026-07-07T06:02:03Z day: '01' ddc: - '000' ec_funded: 1 external_id: cryptoeprintid: - 2025/426 file: - access_level: open_access checksum: fcfe8851aeb751af98c0b1335a0ef149 content_type: application/pdf creator: dernst date_created: 2025-11-24T07:44:08Z date_updated: 2025-11-24T07:44:08Z file_id: '20671' file_name: 2025_Usenix_Hashimoto.pdf file_size: 710733 relation: main_file success: 1 file_date_updated: 2025-11-24T07:44:08Z has_accepted_license: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://eprint.iacr.org/2025/426 month: '01' oa: 1 oa_version: Published Version page: 6699-6716 project: - _id: 2564DBCA-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '665385' name: International IST Doctoral Program publication: 34th Usenix Security Symposium publication_identifier: isbn: - '9781939133526' publication_status: published publisher: Usenix Association quality_controlled: '1' scopus_import: '1' status: public title: 'Exploring how to authenticate application messages in MLS: More efficient, post-quantum, and anonymous blocklistable' type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2025' ...