---
_id: '2486'
abstract:
- lang: eng
text: Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1), which
is linked to phosphoinositide (PI) hydrolysis, was investigated in adult and developing
rat central nervous system (CNS) by in situ hybridization. Transcripts of mGluR1
were specifically localized to neurons and widely distributed throughout the adult
rat brain. Most intensely labeled neurons were Purkinje cells of the cerebellum,
mitral and tufted cells of the olfactory bulb, and neurons in the hippocampus,
lateral septum, thalamus, globus pallidus, entopeduncular nucleus, ventral pallidum,
magnocellular preoptic nucleus, substantia nigra, and dorsal cochlear nucleus.
Moderately labeled neurons were seen in high density in the dentate gyrus, striatum,
islands of Calleja, superficial layers of the retrosplenial, cingulate and entorhinal
cortices, mammillary nuclei, red nucleus, and superior colliculus. In the developing
rat brain, the level of mGluR1 expression gradually increased during early postnatal
days in accordance with the maturation of neuronal elements. These results show
prominent expression of mGluR1 in the major targets of putative glutamatergic
pathways and unique distribution pattern of mGluR1 distinct from those reported
for ionotropic subtypes of glutamate receptors, suggesting specific roles of mGluR1
in the glutamatergic system.
acknowledgement: We are grateful to Mr. Akira Uesugi for photographic help. This
work was supported in part by research grants from Senri Life Science Foundation
and the Ministry of Education, Science and Culture of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Shigemoto R, Nakanishi S, Mizuno N. Distribution of the mRNA for a metabotropic
glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization
study in adult and developing rat. Journal of Comparative Neurology. 1992;322(1):121-135.
doi:10.1002/cne.903220110'
apa: 'Shigemoto, R., Nakanishi, S., & Mizuno, N. (1992). Distribution of the
mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system:
An in situ hybridization study in adult and developing rat. Journal of Comparative
Neurology. Wiley-Blackwell. https://doi.org/10.1002/cne.903220110'
chicago: 'Shigemoto, Ryuichi, Shigetada Nakanishi, and Noboru Mizuno. “Distribution
of the MRNA for a Metabotropic Glutamate Receptor (MGluR1) in the Central Nervous
System: An in Situ Hybridization Study in Adult and Developing Rat.” Journal
of Comparative Neurology. Wiley-Blackwell, 1992. https://doi.org/10.1002/cne.903220110.'
ieee: 'R. Shigemoto, S. Nakanishi, and N. Mizuno, “Distribution of the mRNA for
a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in
situ hybridization study in adult and developing rat,” Journal of Comparative
Neurology, vol. 322, no. 1. Wiley-Blackwell, pp. 121–135, 1992.'
ista: 'Shigemoto R, Nakanishi S, Mizuno N. 1992. Distribution of the mRNA for a
metabotropic glutamate receptor (mGluR1) in the central nervous system: An in
situ hybridization study in adult and developing rat. Journal of Comparative Neurology.
322(1), 121–135.'
mla: 'Shigemoto, Ryuichi, et al. “Distribution of the MRNA for a Metabotropic Glutamate
Receptor (MGluR1) in the Central Nervous System: An in Situ Hybridization Study
in Adult and Developing Rat.” Journal of Comparative Neurology, vol. 322,
no. 1, Wiley-Blackwell, 1992, pp. 121–35, doi:10.1002/cne.903220110.'
short: R. Shigemoto, S. Nakanishi, N. Mizuno, Journal of Comparative Neurology 322
(1992) 121–135.
date_created: 2018-12-11T11:57:57Z
date_published: 1992-08-01T00:00:00Z
date_updated: 2022-03-21T09:41:37Z
day: '01'
doi: 10.1002/cne.903220110
extern: '1'
external_id:
pmid:
- '1430307'
intvolume: ' 322'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://onlinelibrary.wiley.com/doi/10.1002/cne.903220110
month: '08'
oa_version: Published Version
page: 121 - 135
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4415'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in
the central nervous system: An in situ hybridization study in adult and developing
rat'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 322
year: '1992'
...
---
_id: '2531'
abstract:
- lang: eng
text: The distribution of NMDA receptor (NMDAR1) on neurons in the peripheral ganglia
was examined in the adult rat by in situ hybridization. NMDAR1 mRNA was expressed
in all neurons in the sensory and autonomic ganglia examined; in the dorsal root,
trigeminal, nodose, superior cervical, and sphenopalatine ganglia. Possible roles
of the NMDA receptor on the sensory and autonomic ganglion neurons are discussed.
acknowledgement: The photographic help of Mr. Akira Uesugi is gratefully acknowledged.
This work has been supported by research grants from the Ministry of Education,
Science and Culture of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Shigemoto R, Ohishi H, Nakanishi S, Mizuno N. Expression of the mRNA for the
rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion neurons. Neuroscience
Letters. 1992;144(1-2):229-232. doi:10.1016/0304-3940(92)90756-W
apa: Shigemoto, R., Ohishi, H., Nakanishi, S., & Mizuno, N. (1992). Expression
of the mRNA for the rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion
neurons. Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(92)90756-W
chicago: Shigemoto, Ryuichi, Hitoshi Ohishi, Shigetada Nakanishi, and Noboru Mizuno.
“Expression of the MRNA for the Rat NMDA Receptor (NMDAR1) in the Sensory and
Autonomic Ganglion Neurons.” Neuroscience Letters. Elsevier, 1992. https://doi.org/10.1016/0304-3940(92)90756-W.
ieee: R. Shigemoto, H. Ohishi, S. Nakanishi, and N. Mizuno, “Expression of the mRNA
for the rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion neurons,”
Neuroscience Letters, vol. 144, no. 1–2. Elsevier, pp. 229–232, 1992.
ista: Shigemoto R, Ohishi H, Nakanishi S, Mizuno N. 1992. Expression of the mRNA
for the rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion neurons.
Neuroscience Letters. 144(1–2), 229–232.
mla: Shigemoto, Ryuichi, et al. “Expression of the MRNA for the Rat NMDA Receptor
(NMDAR1) in the Sensory and Autonomic Ganglion Neurons.” Neuroscience Letters,
vol. 144, no. 1–2, Elsevier, 1992, pp. 229–32, doi:10.1016/0304-3940(92)90756-W.
short: R. Shigemoto, H. Ohishi, S. Nakanishi, N. Mizuno, Neuroscience Letters 144
(1992) 229–232.
date_created: 2018-12-11T11:58:13Z
date_published: 1992-09-14T00:00:00Z
date_updated: 2022-03-18T13:15:02Z
day: '14'
doi: 10.1016/0304-3940(92)90756-W
extern: '1'
external_id:
pmid:
- '1436707'
intvolume: ' 144'
issue: 1-2
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/030439409290756W
month: '09'
oa_version: None
page: 229 - 232
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4368'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Expression of the mRNA for the rat NMDA receptor (NMDAR1) in the sensory and
autonomic ganglion neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 144
year: '1992'
...
---
_id: '2532'
abstract:
- lang: eng
text: In the present study, we have investigated the expression of both the erythrocyte-type
(GLUT1) and the brain-type (GLUT3) glucose transporter isoforms in primary human
brain tumors. In situ hybridization made it possible to localize and semiquantify
both GLUT1 and GLUT3 mRNAs of individual cells in all 18 samples examined. More
signals for GLUT3 mRNA than for GLUT1 mRNA were found over astrocytoma cells,
while the reverse was the case in all 6 meningiomas. In astrocytomas, for both
mRNAs, the density of silver grains over tumor cells was well correlated with
the malignancy of the cells. This correlation was, as was also confirmed by Northern
blot analysis, more marked with GLUT3 mRNA than with GLUT1 mRNA. In 2 of 5 anaplastic
astrocytomas and in all 3 glioblastomas, numerous tumor cells with large amounts
of both mRNAs tended to surround the perivascular regions. 'Tumor vessels' with
endothelial proliferation, an almost pathognomonic feature of glioblastomas, expressed
much GLUT3 mRNA but no significant GLUT1 mRNA, while a single- or a few-layered
capillary endothelium expressed much GLUT1 mRNA. The distribution of both mRNAs
was in good accordance with that of both proteins. Our results suggest that the
expression of both glucose transporter isoforms may contribute to the maintenance
of human brain tumors and that the expression of the GLUT3 isoform may be closely
related to the malignant change of astrocytomas and particularly related to the
aberrant neovascularization which accompanies glioblastomas.
acknowledgement: 'We wish to acknowledge generous donations of human samples by the
following neurosurgeons: Drs. Taro Fukumitsu. Akinori Kondo, Toyoshiro Yamamoto,
Juji Takeuchi, Junya Hanakita, Syunichi Yoneda, and Michio Nishikawa. We are very
grateful to Dr. G. I. Bell (The University of Chicago) for providing the cDNA clones
of GLUTI and GLUT3. We thank Drs. Yoshifumi Yokota, Yuichiro Yamada. and Manabu
Fukumoto for their helpful advice. We also thank Yoshinobu Toda and Hiroko Sato
for their expert technical assistance. Supported in part by Grants in Aids for Basic
Research on Radiation Therapy (03151034) and Special Project Research on Cancer
Bio-Science from the Ministry of Education, Science, and Culture of Japan, by Takeda
Medical Foundation, and by Monbusho International Scientific Research: Joint Research.'
article_processing_charge: No
article_type: original
author:
- first_name: Tatsuya
full_name: Nishioka, Tatsuya
last_name: Nishioka
- first_name: Yoshifumi
full_name: Oda, Yoshifumi
last_name: Oda
- first_name: Yutaka
full_name: Seino, Yutaka
last_name: Seino
- first_name: Taizo
full_name: Yamamoto, Taizo
last_name: Yamamoto
- first_name: Nobuya
full_name: Inagaki, Nobuya
last_name: Inagaki
- first_name: Hideki
full_name: Yano, Hideki
last_name: Yano
- first_name: Hiroo
full_name: Imura, Hiroo
last_name: Imura
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Haruhiko
full_name: Kikuchi, Haruhiko
last_name: Kikuchi
citation:
ama: Nishioka T, Oda Y, Seino Y, et al. Distribution of the glucose transporters
in human brain tumors. Cancer Research. 1992;52(14):3972-3979.
apa: Nishioka, T., Oda, Y., Seino, Y., Yamamoto, T., Inagaki, N., Yano, H., … Kikuchi,
H. (1992). Distribution of the glucose transporters in human brain tumors. Cancer
Research. American Association for Cancer Research.
chicago: Nishioka, Tatsuya, Yoshifumi Oda, Yutaka Seino, Taizo Yamamoto, Nobuya
Inagaki, Hideki Yano, Hiroo Imura, Ryuichi Shigemoto, and Haruhiko Kikuchi. “Distribution
of the Glucose Transporters in Human Brain Tumors.” Cancer Research. American
Association for Cancer Research, 1992.
ieee: T. Nishioka et al., “Distribution of the glucose transporters in human
brain tumors,” Cancer Research, vol. 52, no. 14. American Association for
Cancer Research, pp. 3972–3979, 1992.
ista: Nishioka T, Oda Y, Seino Y, Yamamoto T, Inagaki N, Yano H, Imura H, Shigemoto
R, Kikuchi H. 1992. Distribution of the glucose transporters in human brain tumors.
Cancer Research. 52(14), 3972–3979.
mla: Nishioka, Tatsuya, et al. “Distribution of the Glucose Transporters in Human
Brain Tumors.” Cancer Research, vol. 52, no. 14, American Association for
Cancer Research, 1992, pp. 3972–79.
short: T. Nishioka, Y. Oda, Y. Seino, T. Yamamoto, N. Inagaki, H. Yano, H. Imura,
R. Shigemoto, H. Kikuchi, Cancer Research 52 (1992) 3972–3979.
date_created: 2018-12-11T11:58:13Z
date_published: 1992-01-01T00:00:00Z
date_updated: 2022-03-17T15:38:42Z
day: '01'
extern: '1'
external_id:
pmid:
- '1617673'
intvolume: ' 52'
issue: '14'
language:
- iso: eng
main_file_link:
- url: https://aacrjournals.org/cancerres/article/52/14/3972/497930/Distribution-of-the-Glucose-Transporters-in-Human
month: '01'
oa_version: None
page: 3972 - 3979
pmid: 1
publication: Cancer Research
publication_identifier:
issn:
- 0008-5472
publication_status: published
publisher: American Association for Cancer Research
publist_id: '4367'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distribution of the glucose transporters in human brain tumors
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 52
year: '1992'
...
---
_id: '2533'
abstract:
- lang: eng
text: A cDNA clone for a new metabotropic glutamate receptor, mGluR5, was isolated
through polymerase chain reaction-mediated DNA amplification by using primer sequences
conserved among the metabotropic glutamate receptor (mGluR) family and by the
subsequent screening of a rat brain cDNA library. The cloned receptor consists
of 1171 amino acid residues and exhibits a structural architecture common to the
mGluR family, possessing a large extracellular domain preceding the seven putative
membrane-spanning segments. mGluR5 shows the highest sequence similarity to mGluR1
among the mGluR members and is coupled to the stimulation of phosphatidylinositol
hydrolysis/ Ca2+ signal transduction in Chinese hamster ovary cells transfected
with the cloned cDNA. This receptor also resembles mGluR1 in its agonist selectivity
and antagonist responses; the potency rank order of agonists for mGluR5 was determined
to be quisqualate > L-glutamate ≥ ibotenate > trans-1-aminocyclopentane-1,3-dicarboxylate.
Blot and in situ hybridization analyses indicated that mGluR5 mRNA is widely distributed
in neuronal cells of the central nervous system and is expressed differently from
mGluR1 mRNA in many brain regions. This investigation thus demonstrates that there
is an additional mGluR subtype which closely resembles mGluR1 in its signal transduction
and pharmacological properties and is expressed in specialized neuronal cells
in the central nervous system.
acknowledgement: We are grateful to Seiji Ito for help of Ca2+ measurements and Akira
Uesugi for photographic assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Takaaki
full_name: Abe, Takaaki
last_name: Abe
- first_name: Hidemitsu
full_name: Sugihara, Hidemitsu
last_name: Sugihara
- first_name: Hiroyuki
full_name: Nawa, Hiroyuki
last_name: Nawa
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Abe T, Sugihara H, Nawa H, Shigemoto R, Mizuno N, Nakanishi S. Molecular characterization
of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+
signal transduction. Journal of Biological Chemistry. 1992;267(19):13361-13368.
doi:10.1016/S0021-9258(18)42219-3
apa: Abe, T., Sugihara, H., Nawa, H., Shigemoto, R., Mizuno, N., & Nakanishi,
S. (1992). Molecular characterization of a novel metabotropic glutamate receptor
mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. Journal of Biological
Chemistry. American Society for Biochemistry and Molecular Biology. https://doi.org/10.1016/S0021-9258(18)42219-3
chicago: Abe, Takaaki, Hidemitsu Sugihara, Hiroyuki Nawa, Ryuichi Shigemoto, Noboru
Mizuno, and Shigetada Nakanishi. “Molecular Characterization of a Novel Metabotropic
Glutamate Receptor MGluR5 Coupled to Inositol Phosphate/Ca2+ Signal Transduction.”
Journal of Biological Chemistry. American Society for Biochemistry and
Molecular Biology, 1992. https://doi.org/10.1016/S0021-9258(18)42219-3.
ieee: T. Abe, H. Sugihara, H. Nawa, R. Shigemoto, N. Mizuno, and S. Nakanishi, “Molecular
characterization of a novel metabotropic glutamate receptor mGluR5 coupled to
inositol phosphate/Ca2+ signal transduction,” Journal of Biological Chemistry,
vol. 267, no. 19. American Society for Biochemistry and Molecular Biology, pp.
13361–13368, 1992.
ista: Abe T, Sugihara H, Nawa H, Shigemoto R, Mizuno N, Nakanishi S. 1992. Molecular
characterization of a novel metabotropic glutamate receptor mGluR5 coupled to
inositol phosphate/Ca2+ signal transduction. Journal of Biological Chemistry.
267(19), 13361–13368.
mla: Abe, Takaaki, et al. “Molecular Characterization of a Novel Metabotropic Glutamate
Receptor MGluR5 Coupled to Inositol Phosphate/Ca2+ Signal Transduction.” Journal
of Biological Chemistry, vol. 267, no. 19, American Society for Biochemistry
and Molecular Biology, 1992, pp. 13361–68, doi:10.1016/S0021-9258(18)42219-3.
short: T. Abe, H. Sugihara, H. Nawa, R. Shigemoto, N. Mizuno, S. Nakanishi, Journal
of Biological Chemistry 267 (1992) 13361–13368.
date_created: 2018-12-11T11:58:14Z
date_published: 1992-07-05T00:00:00Z
date_updated: 2022-03-17T15:08:29Z
day: '05'
doi: 10.1016/S0021-9258(18)42219-3
extern: '1'
external_id:
pmid:
- '1320017'
intvolume: ' 267'
issue: '19'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0021925818422193
month: '07'
oa: 1
oa_version: Published Version
page: 13361 - 13368
pmid: 1
publication: Journal of Biological Chemistry
publication_identifier:
issn:
- 0021-9258
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '4366'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Molecular characterization of a novel metabotropic glutamate receptor mGluR5
coupled to inositol phosphate/Ca2+ signal transduction
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 267
year: '1992'
...
---
_id: '2534'
abstract:
- lang: eng
text: Vasoactive intestinal polypeptide (VIP), a 28 amino acid peptide hormone,
plays many physiological roles in the peripheral and central nerve systems. A
functional cDNA clone of the VIP receptor was isolated from a rat lung cDNA library
by cross-hybridization with the secretin receptor cDNA. VIP bound the cloned VIP
receptor expressed in mouse COP cells and stimulated adenylate cyclase through
the cloned receptor. The rat VIP receptor consists of 459 amino acids with a calculated
Mr of 52,054 and contains seven transmembrane segments. It is structurally related
to the secretin, calcitonin, and parathyroid hormone receptors, suggesting that
they constitute a new subfamily of the G5 protein - coupled receptors. VIP receptor
mRNA was detected in various rat tissues including liver, lung, intestines, and
brain. In situ hybridization revealed that VIP receptor mRNA is widely distributed
in neuronal cells of the adult rat brain, with a relatively high expression in
the cerebral cortex and hippocampus.
acknowledgement: "We thank Drs. R. Yoshida, K. Katoh, and K. lmamura for help with
the in situ hybridization, Dr. M. Nishizawa for discussion, and Ms. M. lkeda for
secretarial assistance. This work was supported in part by a Grant-in-Aid from the
Ministry of Education, Science and Culture of Japan. The costs of publication of
this article were defrayed in part\r\nby the payment of page charges. This article
must therefore be hereby marked “advertisement” in accordance with 18 USC Section
1734 solely to indicate this fact."
article_processing_charge: No
article_type: original
author:
- first_name: Takeshi
full_name: Ishihara, Takeshi
last_name: Ishihara
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Kensaku
full_name: Mori, Kensaku
last_name: Mori
- first_name: Kenji
full_name: Takahashi, Kenji
last_name: Takahashi
- first_name: Shigekazu
full_name: Nagata, Shigekazu
last_name: Nagata
citation:
ama: Ishihara T, Shigemoto R, Mori K, Takahashi K, Nagata S. Functional expression
and tissue distribution of a novel receptor for vasoactive intestinal polypeptide.
Neuron. 1992;8(4):811-819. doi:10.1016/0896-6273(92)90101-I
apa: Ishihara, T., Shigemoto, R., Mori, K., Takahashi, K., & Nagata, S. (1992).
Functional expression and tissue distribution of a novel receptor for vasoactive
intestinal polypeptide. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(92)90101-I
chicago: Ishihara, Takeshi, Ryuichi Shigemoto, Kensaku Mori, Kenji Takahashi, and
Shigekazu Nagata. “Functional Expression and Tissue Distribution of a Novel Receptor
for Vasoactive Intestinal Polypeptide.” Neuron. Elsevier, 1992. https://doi.org/10.1016/0896-6273(92)90101-I.
ieee: T. Ishihara, R. Shigemoto, K. Mori, K. Takahashi, and S. Nagata, “Functional
expression and tissue distribution of a novel receptor for vasoactive intestinal
polypeptide,” Neuron, vol. 8, no. 4. Elsevier, pp. 811–819, 1992.
ista: Ishihara T, Shigemoto R, Mori K, Takahashi K, Nagata S. 1992. Functional expression
and tissue distribution of a novel receptor for vasoactive intestinal polypeptide.
Neuron. 8(4), 811–819.
mla: Ishihara, Takeshi, et al. “Functional Expression and Tissue Distribution of
a Novel Receptor for Vasoactive Intestinal Polypeptide.” Neuron, vol. 8,
no. 4, Elsevier, 1992, pp. 811–19, doi:10.1016/0896-6273(92)90101-I.
short: T. Ishihara, R. Shigemoto, K. Mori, K. Takahashi, S. Nagata, Neuron 8 (1992)
811–819.
date_created: 2018-12-11T11:58:14Z
date_published: 1992-04-01T00:00:00Z
date_updated: 2022-03-17T13:33:07Z
day: '01'
doi: 10.1016/0896-6273(92)90101-I
extern: '1'
external_id:
pmid:
- '1314625'
intvolume: ' 8'
issue: '4'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/089662739290101I?via%3Dihub
month: '04'
oa_version: None
page: 811 - 819
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '4363'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Functional expression and tissue distribution of a novel receptor for vasoactive
intestinal polypeptide
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 8
year: '1992'
...
---
_id: '2535'
abstract:
- lang: eng
text: We report the molecular characterization of two novel rat helix-loop-helix
(HLH) proteins, designated HES-1 and HES-3, that show structural homology to the
Drosophila hairy and Enhancer of split [E(spl)] proteins, both of which are required
for normal neurogenesis. HES-1 mRNA, expressed in various tissues of both embryos
and adults, is present at a high level in the epithelial cells, including the
embryonal neuroepithelial cells, as well as in the mesoderm-derived tissues such
as the embryonal muscle. In contrast, HES-3 mRNA is produced exclusively in cerebellar
Purkinje cells. HES-1 represses transcription by binding to the N box, which is
a recognition sequence of E(spl) proteins. Interestingly, neither HES-1 nor HES-3
alone interacts efficiently with the E box, but each protein decreases the transcription
induced by E-box-binding HLH activators such as E47. Furthermore, HES-1 also inhibits
the functions of MyoD and MASH1 and effectively diminishes the myogenic conversion
of C3H10T1/2 cells induced by MyoD. These results suggest that HES-1 may play
an important role in mammalian development by negatively acting on the two different
sequences while HES-3 acts as a repressor in a specific type of neurons.
acknowledgement: "We thank Professor Noboru Mizuno for his kind help with in situ
hybridization experiments, Akira Uesugi and Dr. Chihiro\r\nAkazawa for photographic
assistance, Drs. Elizabeth Knust and Jose A. Campos-Ortega for communicating their
unpublished results, Dr. Shinji Fushiki for useful discussion, Dr. Mikio Nishizawa
and Professor Shigekazu Nagata for pMNT, Dr. David Baltimore for the E47 expression
vector, Drs. Yoichiro Nabeshima and Atsuko Fujisawa for the MyoD expression vector
and the reporter plasmid with the MCK enhancer, and Dr. Makoto Ishibashi for his
help in isolating the human E47 eDNA clone. This work was supported in part by research
grants from the Ministry of Education, Science, and Culture of Japan. The publication
costs of this article were defrayed in part by payment of page charges. This article
must therefore be hereby marked \"advertisement\" in accordance with 18 USC section
1734 solely to indicate this fact. \r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Yoshiki
full_name: Sasai, Yoshiki
last_name: Sasai
- first_name: Ryoichiro
full_name: Kageyama, Ryoichiro
last_name: Kageyama
- first_name: Yoshiaki
full_name: Tagawa, Yoshiaki
last_name: Tagawa
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Sasai Y, Kageyama R, Tagawa Y, Shigemoto R, Nakanishi S. Two mammalian helix-loop-helix
factors structurally related to Drosophila hairy and Enhancer of split. Genes
and Development. 1992;6(12 B):2620-2634. doi:10.1101/gad.6.12b.2620
apa: Sasai, Y., Kageyama, R., Tagawa, Y., Shigemoto, R., & Nakanishi, S. (1992).
Two mammalian helix-loop-helix factors structurally related to Drosophila hairy
and Enhancer of split. Genes and Development. Cold Spring Harbor Laboratory
Press. https://doi.org/10.1101/gad.6.12b.2620
chicago: Sasai, Yoshiki, Ryoichiro Kageyama, Yoshiaki Tagawa, Ryuichi Shigemoto,
and Shigetada Nakanishi. “Two Mammalian Helix-Loop-Helix Factors Structurally
Related to Drosophila Hairy and Enhancer of Split.” Genes and Development.
Cold Spring Harbor Laboratory Press, 1992. https://doi.org/10.1101/gad.6.12b.2620.
ieee: Y. Sasai, R. Kageyama, Y. Tagawa, R. Shigemoto, and S. Nakanishi, “Two mammalian
helix-loop-helix factors structurally related to Drosophila hairy and Enhancer
of split,” Genes and Development, vol. 6, no. 12 B. Cold Spring Harbor
Laboratory Press, pp. 2620–2634, 1992.
ista: Sasai Y, Kageyama R, Tagawa Y, Shigemoto R, Nakanishi S. 1992. Two mammalian
helix-loop-helix factors structurally related to Drosophila hairy and Enhancer
of split. Genes and Development. 6(12 B), 2620–2634.
mla: Sasai, Yoshiki, et al. “Two Mammalian Helix-Loop-Helix Factors Structurally
Related to Drosophila Hairy and Enhancer of Split.” Genes and Development,
vol. 6, no. 12 B, Cold Spring Harbor Laboratory Press, 1992, pp. 2620–34, doi:10.1101/gad.6.12b.2620.
short: Y. Sasai, R. Kageyama, Y. Tagawa, R. Shigemoto, S. Nakanishi, Genes and Development
6 (1992) 2620–2634.
date_created: 2018-12-11T11:58:15Z
date_published: 1992-01-01T00:00:00Z
date_updated: 2022-03-17T14:52:29Z
day: '01'
doi: 10.1101/gad.6.12b.2620
extern: '1'
external_id:
pmid:
- '1340473'
intvolume: ' 6'
issue: 12 B
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://genesdev.cshlp.org/content/6/12b/2620
month: '01'
oa: 1
oa_version: Published Version
page: 2620 - 2634
pmid: 1
publication: Genes and Development
publication_identifier:
issn:
- 0890-9369
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
publist_id: '4364'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Two mammalian helix-loop-helix factors structurally related to Drosophila hairy
and Enhancer of split
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 6
year: '1992'
...
---
_id: '3469'
abstract:
- lang: eng
text: Glutamate-operated ion channels (GluR channels) of the L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic
acid (AMPA)-kainate subtype are found in both neurons and glial cells of the central
nervous system. These channels are assembled from the GluR-A, -B, -C, and -D subunits;
channels containing a GluR-B subunit show an outwardly rectifying current-voltage
relation and low calcium permeability, whereas channels lacking the GluR-B subunit
are characterized by a doubly rectifying current-voltage relation and high calcium
permeability. Most cell types in the central nervous system coexpress several
subunits, including GluR-B. However, Bergmann glia in rat cerebellum do not express
GluR-B subunit genes. In a subset of cultured cerebellar glial cells, likely derived
from Bergmann glial cells. GluR channels exhibit doubly rectifying current-voltage
relations and high calcium permeability, whereas GluR channels of cerebellar neurons
have low calcium permeability. Thus, differential expression of the GluR-B subunit
gene in neurons and glia is one mechanism by which functional properties of native
GluR channels are regulated.
article_processing_charge: No
article_type: original
author:
- first_name: Nail
full_name: Burnashev, Nail
last_name: Burnashev
- first_name: Alla
full_name: Khodorova, Alla
last_name: Khodorova
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: P.
full_name: Helm, P.
last_name: Helm
- first_name: William
full_name: Wisden, William
last_name: Wisden
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
- first_name: Peter
full_name: Seeburg, Peter
last_name: Seeburg
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
citation:
ama: Burnashev N, Khodorova A, Jonas PM, et al. Calcium-permeable AMPA-kainate receptors
in fusiform cerebellar glial cells. Science. 1992;256(5063):1566-1570.
doi:10.1126/science.1317970
apa: Burnashev, N., Khodorova, A., Jonas, P. M., Helm, P., Wisden, W., Monyer, H.,
… Sakmann, B. (1992). Calcium-permeable AMPA-kainate receptors in fusiform cerebellar
glial cells. Science. American Association for the Advancement of Science.
https://doi.org/10.1126/science.1317970
chicago: Burnashev, Nail, Alla Khodorova, Peter M Jonas, P. Helm, William Wisden,
Hannah Monyer, Peter Seeburg, and Bert Sakmann. “Calcium-Permeable AMPA-Kainate
Receptors in Fusiform Cerebellar Glial Cells.” Science. American Association
for the Advancement of Science, 1992. https://doi.org/10.1126/science.1317970.
ieee: N. Burnashev et al., “Calcium-permeable AMPA-kainate receptors in fusiform
cerebellar glial cells.,” Science, vol. 256, no. 5063. American Association
for the Advancement of Science, pp. 1566–1570, 1992.
ista: Burnashev N, Khodorova A, Jonas PM, Helm P, Wisden W, Monyer H, Seeburg P,
Sakmann B. 1992. Calcium-permeable AMPA-kainate receptors in fusiform cerebellar
glial cells. Science. 256(5063), 1566–1570.
mla: Burnashev, Nail, et al. “Calcium-Permeable AMPA-Kainate Receptors in Fusiform
Cerebellar Glial Cells.” Science, vol. 256, no. 5063, American Association
for the Advancement of Science, 1992, pp. 1566–70, doi:10.1126/science.1317970.
short: N. Burnashev, A. Khodorova, P.M. Jonas, P. Helm, W. Wisden, H. Monyer, P.
Seeburg, B. Sakmann, Science 256 (1992) 1566–1570.
date_created: 2018-12-11T12:03:30Z
date_published: 1992-06-12T00:00:00Z
date_updated: 2022-03-16T13:24:52Z
day: '12'
doi: 10.1126/science.1317970
extern: '1'
external_id:
pmid:
- '1317970'
intvolume: ' 256'
issue: '5063'
language:
- iso: eng
main_file_link:
- url: https://www.science.org/doi/10.1126/science.1317970
month: '06'
oa_version: None
page: 1566 - 1570
pmid: 1
publication: Science
publication_identifier:
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '2918'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Calcium-permeable AMPA-kainate receptors in fusiform cerebellar glial cells.
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 256
year: '1992'
...
---
_id: '3470'
abstract:
- lang: eng
text: Currents activated by glutamate receptor (GluR) agonists were recorded from
outside-out patches isolated from the soma of visually identified pyramidal neurones
of the (CA3 and CA1 region of rat hippocampal slices. α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic
acid (AMPA). L-glutamate (L-Glu), and kainate (KA) were delivered either by bath
application through perfusion of the recording chamber or by rapid application
via a piezo-driven two-barrelled fast application system. 2. Bath application
of each of the three agonists activated inward currents in all patches (n = 134)
at holding potentials of -50 or -60 mV. The current amplitude increased in size
between 3 to 30 μM-AMPA and 100 μM to 1 mM-KA. With this slow mode of bath application,
the responses showed no apparent desensitization even at saturating concentrations
of AMPA (30 μM) and KA (1 mM). 3. The ratio of currents activated by 30 μM-AMPA
and 300 μM-KA showed a characteristic difference between CA3 and CA1 neurones.
The ratio was 0.242 ± 0.028 (mean ± S.E.M., n = 16) for CA3 cell patches and 0.097
± 0.012 (n = 8) for CA1 cell patches indicating that GluRs in the two cell populations
are different. 4. The steady-state current-voltage relations (I-Vs) for AMPA-
and KA-activated currents showed pronounced outward rectification for both cell
types (when the main cations are Na+ in the bath and Cs+ in the pipette solution).
The current reversed close to 0 mV and the ratio of chord conductances 80 mV on
either side of the reversal potential was 2.66 for KA-activated currents in CA3
cell patches and 2.60 in CA1 cell patches. AMPA-activated currents showed a time-dependent
increase after steps to positive membrane potentials and a decrease after steps
to negative voltages, indicating that a gating process is responsible for outward
rectification of the steady-state I-IV. 5. The permeability (P) of GluR channels
was high for Na+ as compared to Cs+ for both cell types (P(Na)/P(Cs) = 0.88 and
0.84). The permeability was low for N-methyl-D-glucamine+ (P(NMG)/P(Cs) ≤ 0.03)
and Ca2+ (P(Ca)/P(Cs) ≤0.05). 6. The current noise level increased during application
of AMPA or KA. Apparent single-channel conductances obtained from fluctuation
analysis were higher for AMPA than for KA, but similar for both cell types. In
CA3 cell patches, AMPA activated channels with an apparent chord conductance of
7.2 pS, KA of 3.0 pS conductance. 7. Fast agonist application revealed desensitization
of GluR channels which was dependent on the type of agonist, currents activated
by AMPA and L-Glu rose rapidly to a peak and then desensitized to a steady-state
current. In contrast, currents activated by fast application of KA rose to a plateau
and did not desensitize. The steady state current expressed as a percentage of
the peak current was higher for L-Glu than for AMPA and slightly higher for CA3
than for CA1 cell patches. For CA3 cell patches, this fraction amounted to 6.2
%, with 300 μM-L-Glu and 2.8%, with 300 μM-AMPA. For CA1 cell patches, corresponding
values were 3.6 and 1.9 % 8. The dose response relations for the peak current
activated by AMPA and L-Glu and the steady-state current activated by KA were
similar for CA3 and CA1 cell patches. The order of potency was AMPA > L-Glu
≃ KA for both cell types EC50 values 189, 342 and 344 μM for CA3 cell patches
and 183, 424 and 474 μM for CA1 cell patches). In all cases, the Hill coefficients
ranged between 12 and 1.7. 8. The rise of AMPA and L-Glu-activated currents became
faster with increasing agonist concentration for both cell types. With L-Glu,
rise times decreased from about 3 ms at 100 μM to 500 μs at 3 mM. The delay for
agonist concentrations ≥ 300 μM was described by the sum of two exponential functions.
The time constant of the predominant fast component was slightly concentration
dependent and decreased from about 12 ms at 300 μM to 8 ms at 3 mM-L-Glu. 10.
The current voltage relations of the peak currents activated by 300 μM-AMPA were
linear for both cell types with a reversal potential close to OmV. 11. It is concluded
that the GluR channels in pyramidal cells of hippocampal CA3 and CA1 regions are
distinet but share many pharmacological and functional properties. Comparison
of the properties of native and recombinant GluRs suggests that in both CA3 and
CA1 regions GluR channels are hetero-oligomers containing the GluR-B subunit.
acknowledgement: "We thank Dr D. Colquhoun, Dr J. P. Ruppersberg and Dr T. A. Verdoorn
for critically reading the manuscript, K. Bauer, C. Busch and F. Helmchen for computer
programming, and M. Kaiser for technical assistance. \r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
citation:
ama: Jonas PM, Sakmann B. Glutamate receptor channels in isolated patches from CA1
and CA3 pyramidal cells of rat hippocampal slices. Journal of Physiology.
1992;455:143-171. doi:10.1113/jphysiol.1992.sp019294
apa: Jonas, P. M., & Sakmann, B. (1992). Glutamate receptor channels in isolated
patches from CA1 and CA3 pyramidal cells of rat hippocampal slices. Journal
of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.1992.sp019294
chicago: Jonas, Peter M, and Bert Sakmann. “Glutamate Receptor Channels in Isolated
Patches from CA1 and CA3 Pyramidal Cells of Rat Hippocampal Slices.” Journal
of Physiology. Wiley-Blackwell, 1992. https://doi.org/10.1113/jphysiol.1992.sp019294 .
ieee: P. M. Jonas and B. Sakmann, “Glutamate receptor channels in isolated patches
from CA1 and CA3 pyramidal cells of rat hippocampal slices,” Journal of Physiology,
vol. 455. Wiley-Blackwell, pp. 143–171, 1992.
ista: Jonas PM, Sakmann B. 1992. Glutamate receptor channels in isolated patches
from CA1 and CA3 pyramidal cells of rat hippocampal slices. Journal of Physiology.
455, 143–171.
mla: Jonas, Peter M., and Bert Sakmann. “Glutamate Receptor Channels in Isolated
Patches from CA1 and CA3 Pyramidal Cells of Rat Hippocampal Slices.” Journal
of Physiology, vol. 455, Wiley-Blackwell, 1992, pp. 143–71, doi:10.1113/jphysiol.1992.sp019294 .
short: P.M. Jonas, B. Sakmann, Journal of Physiology 455 (1992) 143–171.
date_created: 2018-12-11T12:03:30Z
date_published: 1992-09-01T00:00:00Z
date_updated: 2022-03-16T13:01:55Z
day: '01'
doi: '10.1113/jphysiol.1992.sp019294 '
extern: '1'
external_id:
pmid:
- '1282929 '
intvolume: ' 455'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/jphysiol.1992.sp019294
month: '09'
oa: 1
oa_version: Published Version
page: 143 - 171
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2917'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Glutamate receptor channels in isolated patches from CA1 and CA3 pyramidal
cells of rat hippocampal slices
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 455
year: '1992'
...
---
_id: '3471'
abstract:
- lang: eng
text: 1. Outside-out patches were isolated from granule cells of dentate gyrus and
pyramidal cells of CA3 and CA1 regions of rat hippocampal slices. Patches were
exposed briefly to L-glutamate using a piezo-driven double-barrelled application
pipette. 2. Applications of glutamate (1 mM) of 1 ms duration activated patch
currents which rose and decayed rapidly. The 20-80% rise time of these glutamate
receptor (GluR)-mediated currents was usually 0.2-0.6 ms. At -50 mV the peak current
varied from 10 to 500 pA in different patches. 3. The peak current-voltage relation
for brief pulses of 1 mM glutamate was virtually linear in normal extracellular
solution for patches from the three cell types (-100 to 60 mV). 4. The permeability
of GluR channels activated at the peak to Ca2+, relative to K+, was less than
0.1 for all three cell types (under bi-ionic conditions with Ca2+ on the extracellular
side and K+ on the intracellular side of the membrane). 5. The offset decay time
constant of the current following 1 ms pulses of 1 mM glutamate was brief, with
mean values of 3.0 +/- 0.8, 2.5 +/- 0.7, and 2.3 +/- 0.7 ms for dentate, CA3 and
CA1 cell patches, respectively. Offset time constants were independent of membrane
potential and independent of glutamate concentration (200 microM and 1 mM) for
the three cell types. 6. Applications of 1 mM glutamate of 100 ms duration showed
that glutamate responses desensitized rapidly. The time constants for desensitization
were 9.4 +/- 2.7, 11.3 +/- 2.8, and 9.3 +/- 2.8 ms for patches from dentate, CA3
and CA1 cells respectively. Desensitization time constants were only weakly dependent
on glutamate concentration (200 microM and 1 mM) for the three cell types. Thus
offset time constants are about four times faster than desensitization time constants
for both glutamate concentrations. 7. Double pulse application of glutamate indicated
that even a 1 ms pulse of 1 mM glutamate causes partial (about 60%) desensitization
of GluR channels. The time course of recovery from desensitization was slower
in dentate gyrus granule cell patches than in CA3 or CA1 pyramidal cell patches.
8. Desensitization was studied at equilibrium by exposing patches to low glutamate
concentrations for at least 15 s before a 1 ms test pulse of 1 mM glutamate.
acknowledgement: 'We thank Drs N.Burnashev, P. Ruppersberg , and G.Stuart for critically
reading the manuscript, and Marlies Kaiser for technical assistance. D.C.is a recipient
of a Humboldt prize. '
article_processing_charge: No
article_type: original
author:
- first_name: D.
full_name: Colquhoun, D.
last_name: Colquhoun
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
citation:
ama: Colquhoun D, Jonas PM, Sakmann B. Action of brief pulses of glutamate on AMPA/kainate
receptors in patches from different neurones of rat hippocampal slices. Journal
of Physiology. 1992;458:261-287. doi:10.1113/jphysiol.1992.sp019417
apa: Colquhoun, D., Jonas, P. M., & Sakmann, B. (1992). Action of brief pulses
of glutamate on AMPA/kainate receptors in patches from different neurones of rat
hippocampal slices. Journal of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.1992.sp019417
chicago: Colquhoun, D., Peter M Jonas, and Bert Sakmann. “Action of Brief Pulses
of Glutamate on AMPA/Kainate Receptors in Patches from Different Neurones of Rat
Hippocampal Slices.” Journal of Physiology. Wiley-Blackwell, 1992. https://doi.org/10.1113/jphysiol.1992.sp019417.
ieee: D. Colquhoun, P. M. Jonas, and B. Sakmann, “Action of brief pulses of glutamate
on AMPA/kainate receptors in patches from different neurones of rat hippocampal
slices,” Journal of Physiology, vol. 458. Wiley-Blackwell, pp. 261–287,
1992.
ista: Colquhoun D, Jonas PM, Sakmann B. 1992. Action of brief pulses of glutamate
on AMPA/kainate receptors in patches from different neurones of rat hippocampal
slices. Journal of Physiology. 458, 261–287.
mla: Colquhoun, D., et al. “Action of Brief Pulses of Glutamate on AMPA/Kainate
Receptors in Patches from Different Neurones of Rat Hippocampal Slices.” Journal
of Physiology, vol. 458, Wiley-Blackwell, 1992, pp. 261–87, doi:10.1113/jphysiol.1992.sp019417.
short: D. Colquhoun, P.M. Jonas, B. Sakmann, Journal of Physiology 458 (1992) 261–287.
date_created: 2018-12-11T12:03:30Z
date_published: 1992-12-01T00:00:00Z
date_updated: 2022-03-16T12:41:01Z
day: '01'
doi: 10.1113/jphysiol.1992.sp019417
extern: '1'
external_id:
pmid:
- '1338788'
intvolume: ' 458'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175155/
month: '12'
oa: 1
oa_version: Published Version
page: 261 - 287
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2916'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Action of brief pulses of glutamate on AMPA/kainate receptors in patches from
different neurones of rat hippocampal slices
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 458
year: '1992'
...
---
_id: '3472'
abstract:
- lang: eng
text: A novel potassium-selective channel which is active at membrane potentials
between -100 mV and +40 mV has been identified in peripheral myelinated axons
of Xenopus laevis using the patch-clamp technique. At negative potentials with
105 mM-K on both sides of the membrane, the channel at 1 kHz resolution showed
a series of brief openings and closings interrupted by longer closings, resulting
in a flickery bursting activity. Measurements with resolution up to 10 kHz revealed
a single-channel conductance of 49 pS with 105 mM-K and 17 pS with 2.5 mM-K on
the outer side of the membrane. The channel was selective for K ions over Na ions
(PNa/PK = 0.033). The probability of being within a burst in outside-out patches
varied from patch to patch (> 0.2, but often > 0.9), and was independent
of membrane potential. Open-time histograms were satisfactorily described with
a single exponential (tau o = 0.09 msec), closed times with the sum of three exponentials
(tau c = 0.13, 5.9, and 36.6 msec). Sensitivity to external tetraethylammonium
was comparatively low (IC50 = 19.0 mM). External Cs ions reduced the apparent
unitary conductance for inward currents at Em = -90 mV (IC50 = 1.1 mM). Ba and,
more potently, Zn ions lowered not only the apparent single-channel conductance
but also open probability. The local anesthetic bupivacaine with high potency
reduced probability of being within a burst (IC50 = 165 nM). The flickering K
channel is clearly different from the other five types of K channels identified
so far in the same preparation. We suggest that this channel may form the molecular
basis of the resting potential in vertebrate myelinated axons.
acknowledgement: A grant from the Konrad-Adenauer-Stiftung to D.-S.K. is gratefully
acknowledged, and this paper constitutes a part of his dissertation. We thank Drs.
H. Bostock, B. Neumcke, D. Siemen and Mr. G. Reid for reading the manuscript and
Mrs. Elke Schmidt for technical assistance. Financial support was received from
the Deutsche Forschungsgemeinschaft (Vol88/13-2).
article_processing_charge: No
article_type: original
author:
- first_name: Duk
full_name: Koh, Duk
last_name: Koh
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Michael
full_name: Bräu, Michael
last_name: Bräu
- first_name: Werner
full_name: Vogel, Werner
last_name: Vogel
citation:
ama: Koh D, Jonas PM, Bräu M, Vogel W. A TEA-insensitive flickering potassium channel
active around the resting potential in myelinated nerve. Journal of Membrane
Biology. 1992;130:149-162. doi:10.1007/BF00231893
apa: Koh, D., Jonas, P. M., Bräu, M., & Vogel, W. (1992). A TEA-insensitive
flickering potassium channel active around the resting potential in myelinated
nerve. Journal of Membrane Biology. Springer. https://doi.org/10.1007/BF00231893
chicago: Koh, Duk, Peter M Jonas, Michael Bräu, and Werner Vogel. “A TEA-Insensitive
Flickering Potassium Channel Active around the Resting Potential in Myelinated
Nerve.” Journal of Membrane Biology. Springer, 1992. https://doi.org/10.1007/BF00231893.
ieee: D. Koh, P. M. Jonas, M. Bräu, and W. Vogel, “A TEA-insensitive flickering
potassium channel active around the resting potential in myelinated nerve,” Journal
of Membrane Biology, vol. 130. Springer, pp. 149–162, 1992.
ista: Koh D, Jonas PM, Bräu M, Vogel W. 1992. A TEA-insensitive flickering potassium
channel active around the resting potential in myelinated nerve. Journal of Membrane
Biology. 130, 149–162.
mla: Koh, Duk, et al. “A TEA-Insensitive Flickering Potassium Channel Active around
the Resting Potential in Myelinated Nerve.” Journal of Membrane Biology,
vol. 130, Springer, 1992, pp. 149–62, doi:10.1007/BF00231893.
short: D. Koh, P.M. Jonas, M. Bräu, W. Vogel, Journal of Membrane Biology 130 (1992)
149–162.
date_created: 2018-12-11T12:03:30Z
date_published: 1992-01-01T00:00:00Z
date_updated: 2022-03-16T11:15:02Z
day: '01'
doi: 10.1007/BF00231893
extern: '1'
external_id:
pmid:
- '1291683 '
intvolume: ' 130'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/BF00231893
month: '01'
oa_version: None
page: 149 - 162
pmid: 1
publication: Journal of Membrane Biology
publication_identifier:
issn:
- 0022-2631
publication_status: published
publisher: Springer
publist_id: '2915'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A TEA-insensitive flickering potassium channel active around the resting potential
in myelinated nerve
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 130
year: '1992'
...
---
_id: '3581'
abstract:
- lang: eng
text: 'A number of rendering algorithms in computer graphics sort three-dimensional
objects by depth and assume that there is no cycle that makes the sorting impossible.
One way to resolve the problem caused by cycles is to cut the objects into smaller
pieces. In this paper we address the problem of estimating how many such cuts
arc always sufficient. We also consider a few related algorithmic and combinatorial
geometry problems. For example, we demonstrate that n lines in space can be sorted
in randomized expected time O(n4’st’), provided that they define no cycle. We
also prove an 0(n7’4) upper bound on the number of points in space so that there
are n lines with the property that for each point there are at least three noncoplanar
lines that contain it. '
acknowledgement: "* Bernard Chazelle wishes to acknowledge the National Science Foundation
for supporting this research in part under Grant CCR-9002352. Herbert Edelsbrunner
acknowledges the support of the National Science Foundation under grants CCR-8714565
and CCR-8921421. Richard Pollack was supported in part by NSF grant CCR-8901484,
NSA grant MDA904-89-H-2030, and DIMACS, a Science and Technology Center under NSF
grant STC88-09648. Raimund Seidel acknowledges support by NSF grant CCR-8809040.
Mich Sharir was partially supported by the Office of Naval\r\nResearch under Grant
N00014-87-K-0129, by the National Science Foundation under Grant CCR-89-01484, and
by grants from the U.S.-Israeli Binational Science Foundation and the Fund for Basic
Research administered by the Israeli Academy of Sciences."
article_processing_charge: No
article_type: original
author:
- first_name: Bernard
full_name: Chazelle, Bernard
last_name: Chazelle
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Leonidas
full_name: Guibas, Leonidas
last_name: Guibas
- first_name: Richard
full_name: Pollack, Richard
last_name: Pollack
- first_name: Raimund
full_name: Seidel, Raimund
last_name: Seidel
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
- first_name: Jack
full_name: Snoeyink, Jack
last_name: Snoeyink
citation:
ama: 'Chazelle B, Edelsbrunner H, Guibas L, et al. Counting and cutting cycles of
lines and rods in space. Computational Geometry: Theory and Applications.
1992;1(6):305-323. doi:10.1016/0925-7721(92)90009-H'
apa: 'Chazelle, B., Edelsbrunner, H., Guibas, L., Pollack, R., Seidel, R., Sharir,
M., & Snoeyink, J. (1992). Counting and cutting cycles of lines and rods in
space. Computational Geometry: Theory and Applications. Elsevier. https://doi.org/10.1016/0925-7721(92)90009-H'
chicago: 'Chazelle, Bernard, Herbert Edelsbrunner, Leonidas Guibas, Richard Pollack,
Raimund Seidel, Micha Sharir, and Jack Snoeyink. “Counting and Cutting Cycles
of Lines and Rods in Space.” Computational Geometry: Theory and Applications.
Elsevier, 1992. https://doi.org/10.1016/0925-7721(92)90009-H.'
ieee: 'B. Chazelle et al., “Counting and cutting cycles of lines and rods
in space,” Computational Geometry: Theory and Applications, vol. 1, no.
6. Elsevier, pp. 305–323, 1992.'
ista: 'Chazelle B, Edelsbrunner H, Guibas L, Pollack R, Seidel R, Sharir M, Snoeyink
J. 1992. Counting and cutting cycles of lines and rods in space. Computational
Geometry: Theory and Applications. 1(6), 305–323.'
mla: 'Chazelle, Bernard, et al. “Counting and Cutting Cycles of Lines and Rods in
Space.” Computational Geometry: Theory and Applications, vol. 1, no. 6,
Elsevier, 1992, pp. 305–23, doi:10.1016/0925-7721(92)90009-H.'
short: 'B. Chazelle, H. Edelsbrunner, L. Guibas, R. Pollack, R. Seidel, M. Sharir,
J. Snoeyink, Computational Geometry: Theory and Applications 1 (1992) 305–323.'
date_created: 2018-12-11T12:04:04Z
date_published: 1992-06-01T00:00:00Z
date_updated: 2022-03-16T10:41:58Z
day: '01'
doi: 10.1016/0925-7721(92)90009-H
extern: '1'
intvolume: ' 1'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/092577219290009H?via%3Dihub
month: '06'
oa: 1
oa_version: Published Version
page: 305 - 323
publication: 'Computational Geometry: Theory and Applications'
publication_identifier:
issn:
- 0925-7721
publication_status: published
publisher: Elsevier
publist_id: '2804'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Counting and cutting cycles of lines and rods in space
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1
year: '1992'
...
---
_id: '3645'
abstract:
- lang: eng
text: Three components of mating call (pulse duration, cycle length, and fundamental
frequency) were measured and six diagnostic enzyme loci scored across the hybrid
zone between the toads Bombina bombina and B. variegata. All three call components
differ significantly, but only cycle length is diagnostic. The clines in call
coincide with those for enzymes, and have similar widths. This suggests that there
is no strong selection on any of these characters. There are significant correlations
between electrophoretic markers and call components, but these are no stronger
than would be expected if the electrophoretic loci and the genes causing mating
call were neutral. The selection differential on the call is no greater than 6%
of the difference in mean cycle length between the two taxa. There is a substantial
increase in the variance of cycle length in the center of the zone, suggesting
that a small number of loci are involved (≈ three). Recombination between these
loci will hinder the evolution of reinforcement and may partly be responsible
for the lack of premating isolation between B. bombina and B. variegata.
acknowledgement: 'Thanks are due to Drs. A. Leibowitz and P. Mason for help in the
field. N.S. would like to thank Drs. K. Ibrahim and R. Nich-ols for discussions,
and the Szymura family for their hospitality on his visits to Poland. Dr. R. Butlin
provided the program to fit tanh curves to dines. The referees, Prof. A. J. Cain,
Ms. L. Humpage and Dr. J. S. Jones made helpful remarks on earlier drafts of the
manuscript. Ms. L. Ringrose translated articles from German. N.S. was supported
by a NERC studentship, a NERC fellowship and the DHSS, J.S. was supported by the
Polish Academy of Sciences (project MRII/ 6), and N.B. by grants from NERC (GR3/
8002) and SERC (GR/E/08507). '
article_processing_charge: No
article_type: original
author:
- first_name: Neil
full_name: Sanderson, Neil
last_name: Sanderson
- first_name: Jacek
full_name: Szymura, Jacek
last_name: Szymura
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Sanderson N, Szymura J, Barton NH. Variation in mating call across the hybrid
zone between the fire-bellied toads Bombina bombina and B. variegata. Evolution.
1992;46(3):595-607. doi:10.1111/j.1558-5646.1992.tb02068.x
apa: Sanderson, N., Szymura, J., & Barton, N. H. (1992). Variation in mating
call across the hybrid zone between the fire-bellied toads Bombina bombina and
B. variegata. Evolution. Wiley-Blackwell. https://doi.org/10.1111/j.1558-5646.1992.tb02068.x
chicago: Sanderson, Neil, Jacek Szymura, and Nicholas H Barton. “Variation in Mating
Call across the Hybrid Zone between the Fire-Bellied Toads Bombina Bombina and
B. Variegata.” Evolution. Wiley-Blackwell, 1992. https://doi.org/10.1111/j.1558-5646.1992.tb02068.x.
ieee: N. Sanderson, J. Szymura, and N. H. Barton, “Variation in mating call across
the hybrid zone between the fire-bellied toads Bombina bombina and B. variegata,”
Evolution, vol. 46, no. 3. Wiley-Blackwell, pp. 595–607, 1992.
ista: Sanderson N, Szymura J, Barton NH. 1992. Variation in mating call across the
hybrid zone between the fire-bellied toads Bombina bombina and B. variegata. Evolution.
46(3), 595–607.
mla: Sanderson, Neil, et al. “Variation in Mating Call across the Hybrid Zone between
the Fire-Bellied Toads Bombina Bombina and B. Variegata.” Evolution, vol.
46, no. 3, Wiley-Blackwell, 1992, pp. 595–607, doi:10.1111/j.1558-5646.1992.tb02068.x.
short: N. Sanderson, J. Szymura, N.H. Barton, Evolution 46 (1992) 595–607.
date_created: 2018-12-11T12:04:24Z
date_published: 1992-01-01T00:00:00Z
date_updated: 2022-03-16T09:52:55Z
day: '01'
doi: 10.1111/j.1558-5646.1992.tb02068.x
extern: '1'
external_id:
pmid:
- '28568664'
intvolume: ' 46'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1558-5646.1992.tb02068.x
month: '01'
oa_version: None
page: 595 - 607
pmid: 1
publication: Evolution
publication_identifier:
issn:
- 0014-3820
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2738'
quality_controlled: '1'
status: public
title: Variation in mating call across the hybrid zone between the fire-bellied toads
Bombina bombina and B. variegata
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 46
year: '1992'
...
---
_id: '4043'
abstract:
- lang: eng
text: It is shown that a triangulation of a set of n points in the plane that minimizes
the maximum angle can be computed in time O(n2 log n) and space O(n). The algorithm
is fairly easy to implement and is based on the edge-insertion scheme that iteratively
improves an arbitrary initial triangulation. It can be extended to the case where
edges are prescribed, and, within the same time- and space-bounds, it can lexicographically
minimize the sorted angle vector if the point set is in general position. Experimental
results on the efficiency of the algorithm and the quality of the triangulations
obtained are included.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Tiow
full_name: Tan, Tiow
last_name: Tan
- first_name: Roman
full_name: Waupotitsch, Roman
last_name: Waupotitsch
citation:
ama: Edelsbrunner H, Tan T, Waupotitsch R. An O(n^2 log n) time algorithm for the
MinMax angle triangulation. SIAM Journal on Scientific Computing. 1992;13(4):994-1008.
doi:10.1137/0913058
apa: Edelsbrunner, H., Tan, T., & Waupotitsch, R. (1992). An O(n^2 log n) time
algorithm for the MinMax angle triangulation. SIAM Journal on Scientific Computing.
Society for Industrial and Applied Mathematics . https://doi.org/10.1137/0913058
chicago: Edelsbrunner, Herbert, Tiow Tan, and Roman Waupotitsch. “An O(N^2 Log n)
Time Algorithm for the MinMax Angle Triangulation.” SIAM Journal on Scientific
Computing. Society for Industrial and Applied Mathematics , 1992. https://doi.org/10.1137/0913058.
ieee: H. Edelsbrunner, T. Tan, and R. Waupotitsch, “An O(n^2 log n) time algorithm
for the MinMax angle triangulation,” SIAM Journal on Scientific Computing,
vol. 13, no. 4. Society for Industrial and Applied Mathematics , pp. 994–1008,
1992.
ista: Edelsbrunner H, Tan T, Waupotitsch R. 1992. An O(n^2 log n) time algorithm
for the MinMax angle triangulation. SIAM Journal on Scientific Computing. 13(4),
994–1008.
mla: Edelsbrunner, Herbert, et al. “An O(N^2 Log n) Time Algorithm for the MinMax
Angle Triangulation.” SIAM Journal on Scientific Computing, vol. 13, no.
4, Society for Industrial and Applied Mathematics , 1992, pp. 994–1008, doi:10.1137/0913058.
short: H. Edelsbrunner, T. Tan, R. Waupotitsch, SIAM Journal on Scientific Computing
13 (1992) 994–1008.
date_created: 2018-12-11T12:06:36Z
date_published: 1992-07-01T00:00:00Z
date_updated: 2022-03-16T09:35:05Z
day: '01'
doi: 10.1137/0913058
extern: '1'
intvolume: ' 13'
issue: '4'
language:
- iso: eng
main_file_link:
- url: https://epubs.siam.org/doi/10.1137/0913058
month: '07'
oa_version: None
page: 994 - 1008
publication: SIAM Journal on Scientific Computing
publication_identifier:
eissn:
- 1095-7111
issn:
- 0097-5397
publication_status: published
publisher: 'Society for Industrial and Applied Mathematics '
publist_id: '2081'
quality_controlled: '1'
status: public
title: An O(n^2 log n) time algorithm for the MinMax angle triangulation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 13
year: '1992'
...
---
_id: '4046'
abstract:
- lang: eng
text: The main contribution of this work is an O(n log n + k)-time algorithm for
computing all k intersections among n line segments in the plane. This time complexity
is easily shown to be optimal. Within the same asymptotic cost, our algorithm
can also construct the subdivision of the plane defined by the segments and compute
which segment (if any) lies right above (or below) each intersection and each
endpoint. The algorithm has been implemented and performs very well. The storage
requirement is on the order of n + k in the worst case, but it is considerably
lower in practice. To analyze the complexity of the algorithm, an amortization
argument based on a new combinatorial theorem on line arrangements is used.
acknowledgement: "B, Chazelle wishes to acknowledge the National Science Foundation
for supporting this research in part under Grant CCR 87-00917. H, Edelsbrunner is
pleased to acknowledge the support of Amoco Fnd. Fac. Dev. Comput. Sci. 1-6-44862
and the NSF under Grant CCR 87-14565. Permission to copy without fee all or part
of this material is granted provided that the copies are not made or distributed
for direct commercial advantage, the ACM copyright notice and the title of the publication
and its date appear, and notice is given that copying is by permission of the Association
for\r\nComputing Machinery. To copy otherwise, or to republish, requires a fee and/or
specific permission."
article_processing_charge: No
article_type: original
author:
- first_name: Bernard
full_name: Chazelle, Bernard
last_name: Chazelle
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: Chazelle B, Edelsbrunner H. An optimal algorithm for intersecting line segments
in the plane. Journal of the ACM. 1992;39(1):1-54. doi:10.1145/147508.147511
apa: Chazelle, B., & Edelsbrunner, H. (1992). An optimal algorithm for intersecting
line segments in the plane. Journal of the ACM. ACM. https://doi.org/10.1145/147508.147511
chicago: Chazelle, Bernard, and Herbert Edelsbrunner. “An Optimal Algorithm for
Intersecting Line Segments in the Plane.” Journal of the ACM. ACM, 1992.
https://doi.org/10.1145/147508.147511.
ieee: B. Chazelle and H. Edelsbrunner, “An optimal algorithm for intersecting line
segments in the plane,” Journal of the ACM, vol. 39, no. 1. ACM, pp. 1–54,
1992.
ista: Chazelle B, Edelsbrunner H. 1992. An optimal algorithm for intersecting line
segments in the plane. Journal of the ACM. 39(1), 1–54.
mla: Chazelle, Bernard, and Herbert Edelsbrunner. “An Optimal Algorithm for Intersecting
Line Segments in the Plane.” Journal of the ACM, vol. 39, no. 1, ACM, 1992,
pp. 1–54, doi:10.1145/147508.147511.
short: B. Chazelle, H. Edelsbrunner, Journal of the ACM 39 (1992) 1–54.
date_created: 2018-12-11T12:06:37Z
date_published: 1992-01-01T00:00:00Z
date_updated: 2022-03-16T08:32:17Z
day: '01'
doi: 10.1145/147508.147511
extern: '1'
intvolume: ' 39'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://dl.acm.org/doi/10.1145/147508.147511
month: '01'
oa_version: None
page: 1 - 54
publication: Journal of the ACM
publication_identifier:
eissn:
- 1557-735X
issn:
- 0004-5411
publication_status: published
publisher: ACM
publist_id: '2078'
quality_controlled: '1'
scopus_import: '1'
status: public
title: An optimal algorithm for intersecting line segments in the plane
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 39
year: '1992'
...
---
_id: '4047'
abstract:
- lang: eng
text: Arrangements of curves in the plane are fundamental to many problems in computational
and combinatorial geometry (e.g. motion planning, algebraic cell decomposition,
etc.). In this paper we study various topological and combinatorial properties
of such arrangements under some mild assumptions on the shape of the curves, and
develop basic tools for the construction, manipulation, and analysis of these
arrangements. Our main results include a generalization of the zone theorem of
Edelsbrunner (1986) and Chazelle (1985) to arrangements of curves (in which we
show that the combinatorial complexity of the zone of a curve is nearly linear
in the number of curves) and an application of that theorem to obtain a nearly
quadratic incremental algorithm for the construction of such arrangements.
acknowledgement: 'Work on this paper by the first author has been supported by the
National Science Foundation under grant CCR-8714565. Work by the third and sixth
authors has been supported by Office of Naval Research Grant NOOOl4-82-K-0381, by
National Science Foundation Grant No. NSF-DCR-83-20085, by grants from the Digital
Equipment Corporation, and the IBM Corporation. Work by the sixth author has also
been supported by a research grant from the NCRD- the Israeli National Council for
Research and Development. Work by the fourth author has been supported by National
Science Foundation Grant DMS-8501947. '
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Leonidas
full_name: Guibas, Leonidas
last_name: Guibas
- first_name: János
full_name: Pach, János
last_name: Pach
- first_name: Richard
full_name: Pollack, Richard
last_name: Pollack
- first_name: Raimund
full_name: Seidel, Raimund
last_name: Seidel
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
citation:
ama: Edelsbrunner H, Guibas L, Pach J, Pollack R, Seidel R, Sharir M. Arrangements
of curves in the plane - topology, combinatorics, and algorithms. Theoretical
Computer Science. 1992;92(2):319-336. doi:10.1016/0304-3975(92)90319-B
apa: Edelsbrunner, H., Guibas, L., Pach, J., Pollack, R., Seidel, R., & Sharir,
M. (1992). Arrangements of curves in the plane - topology, combinatorics, and
algorithms. Theoretical Computer Science. Elsevier. https://doi.org/10.1016/0304-3975(92)90319-B
chicago: Edelsbrunner, Herbert, Leonidas Guibas, János Pach, Richard Pollack, Raimund
Seidel, and Micha Sharir. “Arrangements of Curves in the Plane - Topology, Combinatorics,
and Algorithms.” Theoretical Computer Science. Elsevier, 1992. https://doi.org/10.1016/0304-3975(92)90319-B.
ieee: H. Edelsbrunner, L. Guibas, J. Pach, R. Pollack, R. Seidel, and M. Sharir,
“Arrangements of curves in the plane - topology, combinatorics, and algorithms,”
Theoretical Computer Science, vol. 92, no. 2. Elsevier, pp. 319–336, 1992.
ista: Edelsbrunner H, Guibas L, Pach J, Pollack R, Seidel R, Sharir M. 1992. Arrangements
of curves in the plane - topology, combinatorics, and algorithms. Theoretical
Computer Science. 92(2), 319–336.
mla: Edelsbrunner, Herbert, et al. “Arrangements of Curves in the Plane - Topology,
Combinatorics, and Algorithms.” Theoretical Computer Science, vol. 92,
no. 2, Elsevier, 1992, pp. 319–36, doi:10.1016/0304-3975(92)90319-B.
short: H. Edelsbrunner, L. Guibas, J. Pach, R. Pollack, R. Seidel, M. Sharir, Theoretical
Computer Science 92 (1992) 319–336.
date_created: 2018-12-11T12:06:37Z
date_published: 1992-01-20T00:00:00Z
date_updated: 2022-03-16T09:04:37Z
day: '20'
doi: 10.1016/0304-3975(92)90319-B
extern: '1'
intvolume: ' 92'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/030439759290319B?via%3Dihub
month: '01'
oa: 1
oa_version: Published Version
page: 319 - 336
publication: Theoretical Computer Science
publication_identifier:
issn:
- 0304-3975
publication_status: published
publisher: Elsevier
publist_id: '2079'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Arrangements of curves in the plane - topology, combinatorics, and algorithms
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 92
year: '1992'
...
---
_id: '4048'
abstract:
- lang: eng
text: 'Given a sequence of n points that form the vertices of a simple polygon,
we show that determining a closest pair requires OMEGA(n log n) time in the algebraic
decision tree model. Together with the well-known O(n log n) upper bound for finding
a closest pair, this settles an open problem of Lee and Preparata. We also extend
this O(n log n) upper bound to the following problem: Given a collection of sets
with a total of n points in the plane, find for each point a closest neighbor
that does not belong to the same set.'
acknowledgement: Research supported by the National Science Foundation under Grant
CCR-8714565.
article_processing_charge: No
article_type: original
author:
- first_name: Alok
full_name: Aggarwal, Alok
last_name: Aggarwal
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Prabhakar
full_name: Raghavan, Prabhakar
last_name: Raghavan
- first_name: Prasoon
full_name: Tiwari, Prasoon
last_name: Tiwari
citation:
ama: Aggarwal A, Edelsbrunner H, Raghavan P, Tiwari P. Optimal time bounds for some
proximity problems in the plane. Information Processing Letters. 1992;42(1):55-60.
doi:10.1016/0020-0190(92)90133-G
apa: Aggarwal, A., Edelsbrunner, H., Raghavan, P., & Tiwari, P. (1992). Optimal
time bounds for some proximity problems in the plane. Information Processing
Letters. Elsevier. https://doi.org/10.1016/0020-0190(92)90133-G
chicago: Aggarwal, Alok, Herbert Edelsbrunner, Prabhakar Raghavan, and Prasoon Tiwari.
“Optimal Time Bounds for Some Proximity Problems in the Plane.” Information
Processing Letters. Elsevier, 1992. https://doi.org/10.1016/0020-0190(92)90133-G.
ieee: A. Aggarwal, H. Edelsbrunner, P. Raghavan, and P. Tiwari, “Optimal time bounds
for some proximity problems in the plane,” Information Processing Letters,
vol. 42, no. 1. Elsevier, pp. 55–60, 1992.
ista: Aggarwal A, Edelsbrunner H, Raghavan P, Tiwari P. 1992. Optimal time bounds
for some proximity problems in the plane. Information Processing Letters. 42(1),
55–60.
mla: Aggarwal, Alok, et al. “Optimal Time Bounds for Some Proximity Problems in
the Plane.” Information Processing Letters, vol. 42, no. 1, Elsevier, 1992,
pp. 55–60, doi:10.1016/0020-0190(92)90133-G.
short: A. Aggarwal, H. Edelsbrunner, P. Raghavan, P. Tiwari, Information Processing
Letters 42 (1992) 55–60.
date_created: 2018-12-11T12:06:38Z
date_published: 1992-04-27T00:00:00Z
date_updated: 2022-03-16T09:20:13Z
day: '27'
doi: 10.1016/0020-0190(92)90133-G
extern: '1'
intvolume: ' 42'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/002001909290133G
month: '04'
oa_version: None
page: 55 - 60
publication: Information Processing Letters
publication_identifier:
eissn:
- 1872-6119
issn:
- 0020-0190
publication_status: published
publisher: Elsevier
publist_id: '2080'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Optimal time bounds for some proximity problems in the plane
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 42
year: '1992'
...
---
_id: '4049'
abstract:
- lang: eng
text: The edge-insertion paradigm improves a triangulation of a finite point set
in R2 iteratively by adding a new edge, deleting intersecting old edges, and retriangulating
the resulting two polygonal regions. After presenting an abstract view of the
paradigm, this paper shows that it can be used to obtain polynomial time algorithms
for several types of optimal triangulations.
acknowledgement: Research of the second author is supported by the National Science
Foundation under grant no. CCR-8921421 and under the Alan T. Waterman award, grant
no. CCR-9118874. Any opinions, finding and conclusions or recommendations expressed
in this publication are those of the authors and do not necessarily reflect the
view of the National Science Foundation. Part of the work was done while the second,
third, and fourth authors visited the Xerox Palo Alto Research Center. The fifth
author is on study leave from the National University of Singapore, Republic of
Singapore.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Marshall
full_name: Bern, Marshall
last_name: Bern
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: David
full_name: Eppstein, David
last_name: Eppstein
- first_name: Stephen
full_name: Mitchell, Stephen
last_name: Mitchell
- first_name: Tiow
full_name: Tan, Tiow
last_name: Tan
citation:
ama: 'Bern M, Edelsbrunner H, Eppstein D, Mitchell S, Tan T. Edge insertion for
optimal triangulations. In: Simon I, ed. 1st Latin American Symposium on Theoretical
Informatics. Vol 583. Springer; 1992:46-60. doi:10.1007/BFb0023816'
apa: 'Bern, M., Edelsbrunner, H., Eppstein, D., Mitchell, S., & Tan, T. (1992).
Edge insertion for optimal triangulations. In I. Simon (Ed.), 1st Latin American
Symposium on Theoretical Informatics (Vol. 583, pp. 46–60). São Paulo, Brazil:
Springer. https://doi.org/10.1007/BFb0023816'
chicago: Bern, Marshall, Herbert Edelsbrunner, David Eppstein, Stephen Mitchell,
and Tiow Tan. “Edge Insertion for Optimal Triangulations.” In 1st Latin American
Symposium on Theoretical Informatics, edited by Imre Simon, 583:46–60. Springer,
1992. https://doi.org/10.1007/BFb0023816.
ieee: M. Bern, H. Edelsbrunner, D. Eppstein, S. Mitchell, and T. Tan, “Edge insertion
for optimal triangulations,” in 1st Latin American Symposium on Theoretical
Informatics, São Paulo, Brazil, 1992, vol. 583, pp. 46–60.
ista: 'Bern M, Edelsbrunner H, Eppstein D, Mitchell S, Tan T. 1992. Edge insertion
for optimal triangulations. 1st Latin American Symposium on Theoretical Informatics.
LATIN: Latin American Symposium on Theoretical Informatics , LNCS, vol. 583, 46–60.'
mla: Bern, Marshall, et al. “Edge Insertion for Optimal Triangulations.” 1st
Latin American Symposium on Theoretical Informatics, edited by Imre Simon,
vol. 583, Springer, 1992, pp. 46–60, doi:10.1007/BFb0023816.
short: M. Bern, H. Edelsbrunner, D. Eppstein, S. Mitchell, T. Tan, in:, I. Simon
(Ed.), 1st Latin American Symposium on Theoretical Informatics, Springer, 1992,
pp. 46–60.
conference:
end_date: 1992-04-10
location: São Paulo, Brazil
name: 'LATIN: Latin American Symposium on Theoretical Informatics '
start_date: 1992-04-06
date_created: 2018-12-11T12:06:38Z
date_published: 1992-04-07T00:00:00Z
date_updated: 2022-03-16T08:04:53Z
day: '07'
doi: 10.1007/BFb0023816
editor:
- first_name: Imre
full_name: Simon, Imre
last_name: Simon
extern: '1'
intvolume: ' 583'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/BFb0023816
month: '04'
oa_version: None
page: 46 - 60
publication: 1st Latin American Symposium on Theoretical Informatics
publication_identifier:
isbn:
- 978-3-540-55284-0
publication_status: published
publisher: Springer
publist_id: '2076'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Edge insertion for optimal triangulations
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 583
year: '1992'
...
---
_id: '4050'
article_processing_charge: No
article_type: letter_note
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: Edelsbrunner H. Guest editor’s foreword. Discrete & Computational Geometry.
1992;8(1):217-217. doi:10.1007/BF02293046
apa: Edelsbrunner, H. (1992). Guest editor’s foreword. Discrete & Computational
Geometry. Springer. https://doi.org/10.1007/BF02293046
chicago: Edelsbrunner, Herbert. “Guest Editor’s Foreword.” Discrete & Computational
Geometry. Springer, 1992. https://doi.org/10.1007/BF02293046.
ieee: H. Edelsbrunner, “Guest editor’s foreword,” Discrete & Computational
Geometry, vol. 8, no. 1. Springer, pp. 217–217, 1992.
ista: Edelsbrunner H. 1992. Guest editor’s foreword. Discrete & Computational
Geometry. 8(1), 217–217.
mla: Edelsbrunner, Herbert. “Guest Editor’s Foreword.” Discrete & Computational
Geometry, vol. 8, no. 1, Springer, 1992, pp. 217–217, doi:10.1007/BF02293046.
short: H. Edelsbrunner, Discrete & Computational Geometry 8 (1992) 217–217.
date_created: 2018-12-11T12:06:39Z
date_published: 1992-08-01T00:00:00Z
date_updated: 2022-03-16T08:15:04Z
day: '01'
doi: 10.1007/BF02293046
extern: '1'
intvolume: ' 8'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/BF02293046
month: '08'
oa_version: None
page: 217 - 217
publication: Discrete & Computational Geometry
publication_status: published
publisher: Springer
publist_id: '2077'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Guest editor's foreword
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 8
year: '1992'
...
---
_id: '4053'
abstract:
- lang: eng
text: We show that the maximum number of edges bounding m faces in an arrangement
of n line segments in the plane is O(m2/3n2/3+nα(n)+nlog m). This improves a previous
upper bound of Edelsbrunner et al. [5] and almost matches the best known lower
bound which is Ω(m2/3n2/3+nα(n)). In addition, we show that the number of edges
bounding any m faces in an arrangement of n line segments with a total of t intersecting
pairs is O(m2/3t1/3+nα(t/n)+nmin{log m,log t/n}), almost matching the lower bound
of Ω(m2/3t1/3+nα(t/n)) demonstrated in this paper.
article_processing_charge: No
article_type: original
author:
- first_name: Boris
full_name: Aronov, Boris
last_name: Aronov
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Leonidas
full_name: Guibas, Leonidas
last_name: Guibas
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
citation:
ama: Aronov B, Edelsbrunner H, Guibas L, Sharir M. The number of edges of many faces
in a line segment arrangement. Combinatorica. 1992;12(3):261-274. doi:10.1007/BF01285815
apa: Aronov, B., Edelsbrunner, H., Guibas, L., & Sharir, M. (1992). The number
of edges of many faces in a line segment arrangement. Combinatorica. Springer.
https://doi.org/10.1007/BF01285815
chicago: Aronov, Boris, Herbert Edelsbrunner, Leonidas Guibas, and Micha Sharir.
“The Number of Edges of Many Faces in a Line Segment Arrangement.” Combinatorica.
Springer, 1992. https://doi.org/10.1007/BF01285815.
ieee: B. Aronov, H. Edelsbrunner, L. Guibas, and M. Sharir, “The number of edges
of many faces in a line segment arrangement,” Combinatorica, vol. 12, no.
3. Springer, pp. 261–274, 1992.
ista: Aronov B, Edelsbrunner H, Guibas L, Sharir M. 1992. The number of edges of
many faces in a line segment arrangement. Combinatorica. 12(3), 261–274.
mla: Aronov, Boris, et al. “The Number of Edges of Many Faces in a Line Segment
Arrangement.” Combinatorica, vol. 12, no. 3, Springer, 1992, pp. 261–74,
doi:10.1007/BF01285815.
short: B. Aronov, H. Edelsbrunner, L. Guibas, M. Sharir, Combinatorica 12 (1992)
261–274.
date_created: 2018-12-11T12:06:40Z
date_published: 1992-09-01T00:00:00Z
date_updated: 2022-03-15T15:44:26Z
day: '01'
doi: 10.1007/BF01285815
extern: '1'
intvolume: ' 12'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/BF01285815
month: '09'
oa_version: None
page: 261 - 274
publication: Combinatorica
publication_identifier:
issn:
- 0209-9683
publication_status: published
publisher: Springer
publist_id: '2074'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The number of edges of many faces in a line segment arrangement
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 12
year: '1992'
...
---
_id: '4195'
abstract:
- lang: eng
text: The effects of tri-iodothyronine (T3), which are known to affect cerebellar
development, were tested on neuronal survival and differentiation of cultured
cerebellar granule neurons. T3 in physiological concentrations increased both
granule neuron survival after three days in culture and synaptic vesicle protein
formation, as shown by immunostaining with antibodies against synaptophysin. Likewise,
T3 increased the mRNA level for synapsin(I), but not that for GAP43 in granule
neurons. Antibodies against microtubule associated protein Tau, which is expressed
in developing neurites, showed that T3 also enhanced neurite formation.
article_processing_charge: No
article_type: original
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Hans
full_name: Thoenen, Hans
last_name: Thoenen
- first_name: Dan
full_name: Lindholm, Dan
last_name: Lindholm
citation:
ama: Heisenberg C-PJ, Thoenen H, Lindholm D. Triiodothyronine Regulates Survival
and Differentiation of Rat Cerebellar Granule Neurons. Neuroreport. 1992;3(8):685-688.
doi:10.1097/00001756-199208000-00008
apa: Heisenberg, C.-P. J., Thoenen, H., & Lindholm, D. (1992). Triiodothyronine
Regulates Survival and Differentiation of Rat Cerebellar Granule Neurons. Neuroreport.
Lippincott, Williams & Wilkins. https://doi.org/10.1097/00001756-199208000-00008
chicago: Heisenberg, Carl-Philipp J, Hans Thoenen, and Dan Lindholm. “Triiodothyronine
Regulates Survival and Differentiation of Rat Cerebellar Granule Neurons.” Neuroreport.
Lippincott, Williams & Wilkins, 1992. https://doi.org/10.1097/00001756-199208000-00008 .
ieee: C.-P. J. Heisenberg, H. Thoenen, and D. Lindholm, “Triiodothyronine Regulates
Survival and Differentiation of Rat Cerebellar Granule Neurons,” Neuroreport,
vol. 3, no. 8. Lippincott, Williams & Wilkins, pp. 685–688, 1992.
ista: Heisenberg C-PJ, Thoenen H, Lindholm D. 1992. Triiodothyronine Regulates Survival
and Differentiation of Rat Cerebellar Granule Neurons. Neuroreport. 3(8), 685–688.
mla: Heisenberg, Carl-Philipp J., et al. “Triiodothyronine Regulates Survival and
Differentiation of Rat Cerebellar Granule Neurons.” Neuroreport, vol. 3,
no. 8, Lippincott, Williams & Wilkins, 1992, pp. 685–88, doi:10.1097/00001756-199208000-00008 .
short: C.-P.J. Heisenberg, H. Thoenen, D. Lindholm, Neuroreport 3 (1992) 685–688.
date_created: 2018-12-11T12:07:31Z
date_published: 1992-01-01T00:00:00Z
date_updated: 2022-03-15T15:25:24Z
day: '01'
doi: '10.1097/00001756-199208000-00008 '
extern: '1'
external_id:
pmid:
- '1387811 '
intvolume: ' 3'
issue: '8'
language:
- iso: eng
main_file_link:
- url: https://journals.lww.com/neuroreport/abstract/1992/08000/tri_iodothyronine_regulates_survival_and.8.aspx
month: '01'
oa_version: None
page: 685 - 688
pmid: 1
publication: Neuroreport
publication_identifier:
eissn:
- 1473-558X
issn:
- 0959-4965
publication_status: published
publisher: Lippincott, Williams & Wilkins
publist_id: '1922'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Triiodothyronine Regulates Survival and Differentiation of Rat Cerebellar Granule
Neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 3
year: '1992'
...