---
_id: '15191'
abstract:
- lang: eng
text: Despite their shared origin, members of globular clusters display star-to-star
variations in composition. The observed pattern of element abundances is unique
to these stellar environments and cannot be fully explained by any proposed mechanism.
It remains unclear whether stars form with chemical heterogeneity or inherit it
from interactions with other members. These scenarios may be differentiated by
the dependence of chemical spread on stellar mass; however, obtaining a sufficiently
large mass baseline requires abundance measurements on the lower main sequence,
which is too faint for spectroscopy even in the nearest globular clusters. We
developed a stellar modeling method to obtain precise chemical abundances for
stars near the end of the main sequence from multiband photometry, and we applied
it to the globular cluster 47 Tucanae. The computational efficiency is attained
by matching chemical elements to the model components that are most sensitive
to their abundance. We determined [O/Fe] for ∼5000 members below the main-sequence
knee at the level of accuracy, comparable to the spectroscopic measurements of
evolved members in the literature. The inferred distribution disfavors stellar
interactions as the origin of chemical spread; however, an accurate theory of
accretion is required to draw a more definitive conclusion. We anticipate that
future observations of 47 Tucanae with the James Webb Space Telescope will extend
the mass baseline of our analysis into the substellar regime. Therefore, we present
predicted color–magnitude diagrams and mass–magnitude relations for the brown
dwarf members of 47 Tucanae.
article_number: '139'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Roman
full_name: Gerasimov, Roman
last_name: Gerasimov
- first_name: Adam J.
full_name: Burgasser, Adam J.
last_name: Burgasser
- first_name: Ilaria
full_name: Caiazzo, Ilaria
id: 8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d
last_name: Caiazzo
orcid: 0000-0002-4770-5388
- first_name: Derek
full_name: Homeier, Derek
last_name: Homeier
- first_name: Harvey B.
full_name: Richer, Harvey B.
last_name: Richer
- first_name: Matteo
full_name: Correnti, Matteo
last_name: Correnti
- first_name: Jeremy
full_name: Heyl, Jeremy
last_name: Heyl
citation:
ama: Gerasimov R, Burgasser AJ, Caiazzo I, et al. Exploring the chemistry and mass
function of the globular cluster 47 Tucanae with new theoretical color–magnitude
diagrams. The Astrophysical Journal. 2024;961(1). doi:10.3847/1538-4357/ad08bf
apa: Gerasimov, R., Burgasser, A. J., Caiazzo, I., Homeier, D., Richer, H. B., Correnti,
M., & Heyl, J. (2024). Exploring the chemistry and mass function of the globular
cluster 47 Tucanae with new theoretical color–magnitude diagrams. The Astrophysical
Journal. American Astronomical Society. https://doi.org/10.3847/1538-4357/ad08bf
chicago: Gerasimov, Roman, Adam J. Burgasser, Ilaria Caiazzo, Derek Homeier, Harvey
B. Richer, Matteo Correnti, and Jeremy Heyl. “Exploring the Chemistry and Mass
Function of the Globular Cluster 47 Tucanae with New Theoretical Color–Magnitude
Diagrams.” The Astrophysical Journal. American Astronomical Society, 2024.
https://doi.org/10.3847/1538-4357/ad08bf.
ieee: R. Gerasimov et al., “Exploring the chemistry and mass function of
the globular cluster 47 Tucanae with new theoretical color–magnitude diagrams,”
The Astrophysical Journal, vol. 961, no. 1. American Astronomical Society,
2024.
ista: Gerasimov R, Burgasser AJ, Caiazzo I, Homeier D, Richer HB, Correnti M, Heyl
J. 2024. Exploring the chemistry and mass function of the globular cluster 47
Tucanae with new theoretical color–magnitude diagrams. The Astrophysical Journal.
961(1), 139.
mla: Gerasimov, Roman, et al. “Exploring the Chemistry and Mass Function of the
Globular Cluster 47 Tucanae with New Theoretical Color–Magnitude Diagrams.” The
Astrophysical Journal, vol. 961, no. 1, 139, American Astronomical Society,
2024, doi:10.3847/1538-4357/ad08bf.
short: R. Gerasimov, A.J. Burgasser, I. Caiazzo, D. Homeier, H.B. Richer, M. Correnti,
J. Heyl, The Astrophysical Journal 961 (2024).
date_created: 2024-03-26T09:44:50Z
date_published: 2024-01-22T00:00:00Z
date_updated: 2024-04-02T06:52:43Z
day: '22'
doi: 10.3847/1538-4357/ad08bf
extern: '1'
external_id:
arxiv:
- '2310.11800'
fulldoi: https://doi.org/10.3847/1538-4357/ad08bf
intvolume: ' 961'
issue: '1'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.3847/1538-4357/ad08bf
month: '01'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: American Astronomical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Exploring the chemistry and mass function of the globular cluster 47 Tucanae
with new theoretical color–magnitude diagrams
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 961
year: '2024'
...
---
OA_place: publisher
OA_type: hybrid
_id: '15248'
abstract:
- lang: eng
text: Applying the technique of p-adic integration, we prove the topological mirror
symmetry conjecture of Hausel-Thaddeus for the moduli spaces of (strongly) parabolic
Higgs bundles for the structure groups SLn and PGLn, building on previous work
of Groechenig-Wyss-Ziegler on the non-parabolic case. We also prove the E-polynomial
of the smooth moduli space of parabolic GLn-Higgs bundles is independent of the
degree of the underlying vector bundles.
acknowledgement: Shiyu Shen has received funding from the European Union's Horizon
2020 research and innovation program under the Marie Skłodowska-Curie grant agreement
No. 101034413.
article_number: '109616'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Shiyu
full_name: Shen, Shiyu
id: 544cccd3-9005-11ec-87bc-94aef1c5b814
last_name: Shen
orcid: 0000-0002-4444-8718
citation:
ama: Shen S. Mirror symmetry for parabolic Higgs bundles via p-adic integration.
Advances in Mathematics. 2024;443(5). doi:10.1016/j.aim.2024.109616
apa: Shen, S. (2024). Mirror symmetry for parabolic Higgs bundles via p-adic integration.
Advances in Mathematics. Elsevier. https://doi.org/10.1016/j.aim.2024.109616
chicago: Shen, Shiyu. “Mirror Symmetry for Parabolic Higgs Bundles via P-Adic Integration.”
Advances in Mathematics. Elsevier, 2024. https://doi.org/10.1016/j.aim.2024.109616.
ieee: S. Shen, “Mirror symmetry for parabolic Higgs bundles via p-adic integration,”
Advances in Mathematics, vol. 443, no. 5. Elsevier, 2024.
ista: Shen S. 2024. Mirror symmetry for parabolic Higgs bundles via p-adic integration.
Advances in Mathematics. 443(5), 109616.
mla: Shen, Shiyu. “Mirror Symmetry for Parabolic Higgs Bundles via P-Adic Integration.”
Advances in Mathematics, vol. 443, no. 5, 109616, Elsevier, 2024, doi:10.1016/j.aim.2024.109616.
short: S. Shen, Advances in Mathematics 443 (2024).
corr_author: '1'
date_created: 2024-03-31T22:01:11Z
date_published: 2024-05-01T00:00:00Z
date_updated: 2025-09-04T13:21:18Z
day: '01'
ddc:
- '510'
department:
- _id: TaHa
doi: 10.1016/j.aim.2024.109616
ec_funded: 1
external_id:
arxiv:
- '2302.02817'
isi:
- '001216128200001'
file:
- access_level: open_access
checksum: 68f2f08136ccf547891a16a2c0621e97
content_type: application/pdf
creator: dernst
date_created: 2024-07-22T12:10:03Z
date_updated: 2024-07-22T12:10:03Z
file_id: '17315'
file_name: 2024_AdvancesMath_Shen.pdf
file_size: 702889
relation: main_file
success: 1
file_date_updated: 2024-07-22T12:10:03Z
fulldoi: https://doi.org/10.1016/j.aim.2024.109616
has_accepted_license: '1'
intvolume: ' 443'
isi: 1
issue: '5'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: Advances in Mathematics
publication_identifier:
eissn:
- 1090-2082
issn:
- 0001-8708
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mirror symmetry for parabolic Higgs bundles via p-adic integration
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 443
year: '2024'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '15249'
abstract:
- lang: eng
text: Observationally mapping the relation between galaxies and the intergalactic
medium (IGM) is of key interest for studies of cosmic reionization. Diffuse hydrogen
gas has typically been observed in H I Lyman-α (Lyα) absorption in the spectra
of bright background quasars. However, it is important to extend these measurements
to background galaxies as quasars become increasingly rare at high redshift and
rarely probe closely separated sight lines. Here, we use deep integral field spectroscopy
in the MUSE eXtremely Deep Field to demonstrate the measurement of the Lyα transmission
at z ≈ 4 in absorption to a background galaxy at z = 4.77. The H I transmission
is consistent with independent quasar sight lines at similar redshifts. Exploiting
the high number of spectroscopic redshifts of faint galaxies (500 between z =
4.0–4.7 within a radius of 8 arcmin) that are tracers of the density field, we
show that Lyα transmission is inversely correlated with galaxy density, i.e. transparent
regions in the Lyα forest mark underdense regions at z ≈ 4. Due to large-scale
clustering, galaxies are surrounded by excess H I absorption over the cosmic mean
out to 4 cMpc/h70. We also find that redshifts from the peak of the Lyα line are
typically offset from the systemic redshift by +170 km s−1. This work extends
results from z ≈ 2–3 to higher redshifts and demonstrates the power of deep integral
field spectroscopy to simultaneously measure the ionization structure of the IGM
and the large-scale density field in the early Universe.
acknowledgement: We thank the referee for constructive comments that helped improving
the paper. Based on observations collected at the European Southern Observatory
under ESO programme 1101.A-0127. Funded by the European Union (ERC, AGENTS, 101076224).
Views and opinions expressed are however those of the author(s) only and do not
necessarily reflect those of the European Union or the European Research Council.
Neither the European Union nor the granting authority can be held responsible for
them. GP acknowledges support from the Netherlands Research School for Astronomy
(Nederlandse Onderzoekschool Voor Astronomie, NOVA). JB acknowledges financial support
from the Fundação para a Ciência e a Tecnologia (FCT) through national funds PTDC/FIS-AST/4862/2020,
work contract 2020.03379.CEECIND, and research grants UIDB/04434/2020 and UIDP/04434/2020.
TU and LW acknowledge funding by the European Research Council through ERC-AdG SPECMAP-CGM,
GA 101020943. TG is supported by the ERC Starting grant 757258 ‘TRIPLE’.
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Christopher
full_name: Golling, Christopher
last_name: Golling
- first_name: Ruari
full_name: Mackenzie, Ruari
last_name: Mackenzie
- first_name: Gabriele
full_name: Pezzulli, Gabriele
last_name: Pezzulli
- first_name: Simon
full_name: Lilly, Simon
last_name: Lilly
- first_name: Joop
full_name: Schaye, Joop
last_name: Schaye
- first_name: Roland
full_name: Bacon, Roland
last_name: Bacon
- first_name: Haruka
full_name: Kusakabe, Haruka
last_name: Kusakabe
- first_name: Tanya
full_name: Urrutia, Tanya
last_name: Urrutia
- first_name: Leindert
full_name: Boogaard, Leindert
last_name: Boogaard
- first_name: Jarle
full_name: Brinchmann, Jarle
last_name: Brinchmann
- first_name: Michael V.
full_name: Maseda, Michael V.
last_name: Maseda
- first_name: Thibault
full_name: Garel, Thibault
last_name: Garel
- first_name: Nicolas F.
full_name: Bouché, Nicolas F.
last_name: Bouché
- first_name: Lutz
full_name: Wisotzki, Lutz
last_name: Wisotzki
citation:
ama: Matthee JJ, Golling C, Mackenzie R, et al. Large-scale excess H I absorption
around z ≈ 4 galaxies detected in a background galaxy spectrum in the MUSE eXtremely
deep field. Monthly Notices of the Royal Astronomical Society. 2024;529(3):2794-2806.
doi:10.1093/mnras/stae673
apa: Matthee, J. J., Golling, C., Mackenzie, R., Pezzulli, G., Lilly, S., Schaye,
J., … Wisotzki, L. (2024). Large-scale excess H I absorption around z ≈ 4 galaxies
detected in a background galaxy spectrum in the MUSE eXtremely deep field. Monthly
Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/stae673
chicago: Matthee, Jorryt J, Christopher Golling, Ruari Mackenzie, Gabriele Pezzulli,
Simon Lilly, Joop Schaye, Roland Bacon, et al. “Large-Scale Excess H I Absorption
around z ≈ 4 Galaxies Detected in a Background Galaxy Spectrum in the MUSE EXtremely
Deep Field.” Monthly Notices of the Royal Astronomical Society. Oxford
University Press, 2024. https://doi.org/10.1093/mnras/stae673.
ieee: J. J. Matthee et al., “Large-scale excess H I absorption around z ≈
4 galaxies detected in a background galaxy spectrum in the MUSE eXtremely deep
field,” Monthly Notices of the Royal Astronomical Society, vol. 529, no.
3. Oxford University Press, pp. 2794–2806, 2024.
ista: Matthee JJ, Golling C, Mackenzie R, Pezzulli G, Lilly S, Schaye J, Bacon R,
Kusakabe H, Urrutia T, Boogaard L, Brinchmann J, Maseda MV, Garel T, Bouché NF,
Wisotzki L. 2024. Large-scale excess H I absorption around z ≈ 4 galaxies detected
in a background galaxy spectrum in the MUSE eXtremely deep field. Monthly Notices
of the Royal Astronomical Society. 529(3), 2794–2806.
mla: Matthee, Jorryt J., et al. “Large-Scale Excess H I Absorption around z ≈ 4
Galaxies Detected in a Background Galaxy Spectrum in the MUSE EXtremely Deep Field.”
Monthly Notices of the Royal Astronomical Society, vol. 529, no. 3, Oxford
University Press, 2024, pp. 2794–806, doi:10.1093/mnras/stae673.
short: J.J. Matthee, C. Golling, R. Mackenzie, G. Pezzulli, S. Lilly, J. Schaye,
R. Bacon, H. Kusakabe, T. Urrutia, L. Boogaard, J. Brinchmann, M.V. Maseda, T.
Garel, N.F. Bouché, L. Wisotzki, Monthly Notices of the Royal Astronomical Society
529 (2024) 2794–2806.
corr_author: '1'
date_created: 2024-03-31T22:01:12Z
date_published: 2024-04-01T00:00:00Z
date_updated: 2025-09-04T13:18:02Z
day: '01'
ddc:
- '520'
department:
- _id: JoMa
doi: 10.1093/mnras/stae673
external_id:
arxiv:
- '2305.15346'
isi:
- '001188770300019'
file:
- access_level: open_access
checksum: 1e65c40a71e565eebdc4c5ff11822ba2
content_type: application/pdf
creator: dernst
date_created: 2024-04-02T08:42:17Z
date_updated: 2024-04-02T08:42:17Z
file_id: '15255'
file_name: 2024_MonthlyNRoyalAstronSoc_Matthee.pdf
file_size: 2626735
relation: main_file
success: 1
file_date_updated: 2024-04-02T08:42:17Z
fulldoi: https://doi.org/10.1093/mnras/stae673
has_accepted_license: '1'
intvolume: ' 529'
isi: 1
issue: '3'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 2794-2806
project:
- _id: bd9b2118-d553-11ed-ba76-db24564edfea
grant_number: '101076224'
name: Young galaxies as tracers and agents of cosmic reionization
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Large-scale excess H I absorption around z ≈ 4 galaxies detected in a background
galaxy spectrum in the MUSE eXtremely deep field
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 529
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '15251'
abstract:
- lang: eng
text: Brassinosteroids are steroidal phytohormones that regulate plant development
and physiology, including adaptation to environmental stresses. Brassinosteroids
are synthesized in the cell interior but bind receptors at the cell surface, necessitating
a yet to be identified export mechanism. Here, we show that a member of the ATP-binding
cassette (ABC) transporter superfamily, ABCB19, functions as a brassinosteroid
exporter. We present its structure in both the substrate-unbound and the brassinosteroid-bound
states. Bioactive brassinosteroids are potent activators of ABCB19 ATP hydrolysis
activity, and transport assays showed that ABCB19 transports brassinosteroids.
In Arabidopsis thaliana, ABCB19 and its close homolog, ABCB1, positively regulate
brassinosteroid responses. Our results uncover an elusive export mechanism for
bioactive brassinosteroids that is tightly coordinated with brassinosteroid signaling.
acknowledgement: "We thank the Cryo-EM Center of the University of Science and Technology
of China for the EM facility support, Y. Yin (Iowa State University, Ames, IA, USA)
for providing the anti-BES1 antibody, Y. Gao and all other staff members for their
technical support on cryo-EM data collection, S. Vanneste (VIB, Ghent University,
Ghent, Belgium) for useful discussions, and M. De Cock for help in preparing the
manuscript.\r\nThis work was supported by the National Natural Science Foundation
of China (grants 31870732 and 32322041 to L.S., grant 31900885 to X.L., and grant
32321001 to L.S.); the Strategic Priority Research Program of the Chinese Academy
of Sciences (grant XDB37020103 to L.S.); the Natural Science Foundation of Anhui
Province (grant 2008085MC90 to X.L. and grant 2008085J15 to L.S.); Fundamental Research
Funds for the Central Universities (grant WK9100000031 to L.S.); USTC Research Funds
of the Double First-Class Initiative (grant YD9100002004 to L.S. and grant YD9100002020
to X.L.); Research Foundation-Flanders (grant G002121N to E.R. and postdoctoral
fellowships 12R7822N and 12R7819N to N.V.); and Chinese Scholarship Council predoctoral
fellowships (Y.W. and H.Z.). L.S. is supported by an Outstanding Young Scholar Award
from the Qiu Shi Science and Technologies Foundation and a Young Scholar Award from
the Cyrus Tang Foundation."
article_processing_charge: No
article_type: original
author:
- first_name: Wei
full_name: Ying, Wei
last_name: Ying
- first_name: Yaowei
full_name: Wang, Yaowei
last_name: Wang
- first_name: Hong
full_name: Wei, Hong
last_name: Wei
- first_name: Yongming
full_name: Luo, Yongming
last_name: Luo
- first_name: Qian
full_name: Ma, Qian
last_name: Ma
- first_name: Heyuan
full_name: Zhu, Heyuan
last_name: Zhu
- first_name: Hilde
full_name: Janssens, Hilde
last_name: Janssens
- first_name: Nemanja
full_name: Vukašinović, Nemanja
last_name: Vukašinović
- first_name: Miroslav
full_name: Kvasnica, Miroslav
last_name: Kvasnica
- first_name: Johan M.
full_name: Winne, Johan M.
last_name: Winne
- first_name: Yongxiang
full_name: Gao, Yongxiang
last_name: Gao
- first_name: Shutang
full_name: Tan, Shutang
id: 2DE75584-F248-11E8-B48F-1D18A9856A87
last_name: Tan
orcid: 0000-0002-0471-8285
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Xin
full_name: Liu, Xin
last_name: Liu
- first_name: Eugenia
full_name: Russinova, Eugenia
last_name: Russinova
- first_name: Linfeng
full_name: Sun, Linfeng
last_name: Sun
citation:
ama: Ying W, Wang Y, Wei H, et al. Structure and function of the Arabidopsis ABC
transporter ABCB19 in brassinosteroid export. Science. 2024;383(6689):eadj4591.
doi:10.1126/science.adj4591
apa: Ying, W., Wang, Y., Wei, H., Luo, Y., Ma, Q., Zhu, H., … Sun, L. (2024). Structure
and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export.
Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.adj4591
chicago: Ying, Wei, Yaowei Wang, Hong Wei, Yongming Luo, Qian Ma, Heyuan Zhu, Hilde
Janssens, et al. “Structure and Function of the Arabidopsis ABC Transporter ABCB19
in Brassinosteroid Export.” Science. American Association for the Advancement
of Science, 2024. https://doi.org/10.1126/science.adj4591.
ieee: W. Ying et al., “Structure and function of the Arabidopsis ABC transporter
ABCB19 in brassinosteroid export,” Science, vol. 383, no. 6689. American
Association for the Advancement of Science, p. eadj4591, 2024.
ista: Ying W, Wang Y, Wei H, Luo Y, Ma Q, Zhu H, Janssens H, Vukašinović N, Kvasnica
M, Winne JM, Gao Y, Tan S, Friml J, Liu X, Russinova E, Sun L. 2024. Structure
and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export.
Science. 383(6689), eadj4591.
mla: Ying, Wei, et al. “Structure and Function of the Arabidopsis ABC Transporter
ABCB19 in Brassinosteroid Export.” Science, vol. 383, no. 6689, American
Association for the Advancement of Science, 2024, p. eadj4591, doi:10.1126/science.adj4591.
short: W. Ying, Y. Wang, H. Wei, Y. Luo, Q. Ma, H. Zhu, H. Janssens, N. Vukašinović,
M. Kvasnica, J.M. Winne, Y. Gao, S. Tan, J. Friml, X. Liu, E. Russinova, L. Sun,
Science 383 (2024) eadj4591.
date_created: 2024-03-31T22:01:12Z
date_published: 2024-03-22T00:00:00Z
date_updated: 2025-09-04T13:19:48Z
day: '22'
department:
- _id: JiFr
doi: 10.1126/science.adj4591
external_id:
isi:
- '001252955200028'
pmid:
- '38513023'
fulldoi: https://doi.org/10.1126/science.adj4591
intvolume: ' 383'
isi: 1
issue: '6689'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://hdl.handle.net/1854/LU-01HTMBK3P3PPNB73YFCMFXP3ZZ
month: '03'
oa: 1
oa_version: Submitted Version
page: eadj4591
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid
export
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 383
year: '2024'
...
---
_id: '15253'
abstract:
- lang: eng
text: "We study the problem of maintaining a differentially private decaying sum
under continual observation. We give a unifying framework and an efficient algorithm
for this problem for any sufficiently smooth function. Our algorithm is the first
differentially private algorithm that does not have a multiplicative error for
polynomially decaying weights. Our algorithm improves on all prior works on differentially
private decaying sums under continual observation and recovers exactly the additive
error for the special case of continual counting from Henzinger et al. (SODA 2023)
as a corollary.\r\nOur algorithm is a variant of the matrix mechanism whose error
depends on the γ2 and γF norm of the underlying matrix. We give a constructive
proof for an almost exact upper bound on the γ2 and γF norm and an almost tight
lower bound on the γ2 norm for a large class of lower-triangular matrices. This
is the first non-trivial lower bound for lower-triangular matrices whose non-zero
entries are not all the same. It includes matrices for all continual decaying
sums problems, resulting in an upper bound on the additive error of any differentially
private decaying sums algorithm under continual observation.\r\nWe also explore
some implications of our result in discrepancy theory and operator algebra. Given
the importance of the γ2 norm in computer science and the extensive work in mathematics,
we believe our result will have further applications."
acknowledgement: This project has received funding from the European Research Council (ERC)under
the European Union’s Horizon 2020 research and innovation programme (Grant agreement
No.101019564 “The Design of Modern Fully Dynamic Data Structures (MoDynStruct)”
and the AustrianScience Fund (FWF) project Z 422-N, project “Static and Dynamic
Hierarchical Graph Decompositions”, I 5982-N, andproject “Fast Algorithms for a
Reactive Network Layer (ReactNet)”, P 33775-N, with additional funding from the
netideeSCIENCE Stiftung, 2020–2024. JU’s research was funded by the Decanal Research Grant. We thank the anonymousreviewers
for their useful feedback and pointing us to the results in Matousek et al
article_processing_charge: No
arxiv: 1
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Jalaj
full_name: Upadhyay, Jalaj
last_name: Upadhyay
- first_name: Sarvagya
full_name: Upadhyay, Sarvagya
last_name: Upadhyay
citation:
ama: 'Henzinger M, Upadhyay J, Upadhyay S. A unifying framework for differentially
private sums under continual observation. In: Proceedings of the 2024 Annual
ACM-SIAM Symposium on Discrete Algorithms. Vol 2024. Society for Industrial
and Applied Mathematics; 2024:995-1018. doi:10.1137/1.9781611977912.38'
apa: 'Henzinger, M., Upadhyay, J., & Upadhyay, S. (2024). A unifying framework
for differentially private sums under continual observation. In Proceedings
of the 2024 Annual ACM-SIAM Symposium on Discrete Algorithms (Vol. 2024, pp.
995–1018). Alexandria, VA, United States: Society for Industrial and Applied Mathematics.
https://doi.org/10.1137/1.9781611977912.38'
chicago: Henzinger, Monika, Jalaj Upadhyay, and Sarvagya Upadhyay. “A Unifying Framework
for Differentially Private Sums under Continual Observation.” In Proceedings
of the 2024 Annual ACM-SIAM Symposium on Discrete Algorithms, 2024:995–1018.
Society for Industrial and Applied Mathematics, 2024. https://doi.org/10.1137/1.9781611977912.38.
ieee: M. Henzinger, J. Upadhyay, and S. Upadhyay, “A unifying framework for differentially
private sums under continual observation,” in Proceedings of the 2024 Annual
ACM-SIAM Symposium on Discrete Algorithms, Alexandria, VA, United States,
2024, vol. 2024, pp. 995–1018.
ista: 'Henzinger M, Upadhyay J, Upadhyay S. 2024. A unifying framework for differentially
private sums under continual observation. Proceedings of the 2024 Annual ACM-SIAM
Symposium on Discrete Algorithms. SODA: Symposium on Discrete Algorithms vol.
2024, 995–1018.'
mla: Henzinger, Monika, et al. “A Unifying Framework for Differentially Private
Sums under Continual Observation.” Proceedings of the 2024 Annual ACM-SIAM
Symposium on Discrete Algorithms, vol. 2024, Society for Industrial and Applied
Mathematics, 2024, pp. 995–1018, doi:10.1137/1.9781611977912.38.
short: M. Henzinger, J. Upadhyay, S. Upadhyay, in:, Proceedings of the 2024 Annual
ACM-SIAM Symposium on Discrete Algorithms, Society for Industrial and Applied
Mathematics, 2024, pp. 995–1018.
conference:
end_date: 2024-01-10
location: Alexandria, VA, United States
name: 'SODA: Symposium on Discrete Algorithms'
start_date: 2024-01-07
corr_author: '1'
date_created: 2024-03-31T22:01:13Z
date_published: 2024-01-04T00:00:00Z
date_updated: 2025-04-14T13:50:49Z
day: '04'
department:
- _id: MoHe
doi: 10.1137/1.9781611977912.38
ec_funded: 1
external_id:
arxiv:
- '2307.08970'
fulldoi: https://doi.org/10.1137/1.9781611977912.38
intvolume: ' 2024'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2307.08970
month: '01'
oa: 1
oa_version: Preprint
page: 995-1018
project:
- _id: bd9ca328-d553-11ed-ba76-dc4f890cfe62
call_identifier: H2020
grant_number: '101019564'
name: The design and evaluation of modern fully dynamic data structures
- _id: 34def286-11ca-11ed-8bc3-da5948e1613c
grant_number: Z00422
name: Efficient algorithms
- _id: bda196b2-d553-11ed-ba76-8e8ee6c21103
grant_number: I05982
name: Static and Dynamic Hierarchical Graph Decompositions
- _id: bd9e3a2e-d553-11ed-ba76-8aa684ce17fe
grant_number: P33775
name: Fast Algorithms for a Reactive Network Layer
publication: Proceedings of the 2024 Annual ACM-SIAM Symposium on Discrete Algorithms
publication_identifier:
eisbn:
- '9781611977912'
publication_status: published
publisher: Society for Industrial and Applied Mathematics
quality_controlled: '1'
scopus_import: '1'
status: public
title: A unifying framework for differentially private sums under continual observation
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2024
year: '2024'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '15258'
abstract:
- lang: eng
text: Inclusion at academic events is facing increased scrutiny as the communities
these events serve raise their expectations for who can practically attend. Active
efforts in recent years to bring more diversity to academic events have brought
progress and created momentum. However, we must reflect on these efforts and determine
which underrepresented groups are being disadvantaged. Inclusion at academic events
is important to ensure diversity of discourse and opinion, to help build networks,
and to avoid academic siloing. All of these contribute to the development of a
robust and resilient academic field. We have developed these Ten Simple Rules
both to amplify the voices that have been speaking out and to celebrate the progress
of many Equity, Diversity, and Inclusivity practices that continue to drive the
organisation of academic events. The Rules aim to raise awareness as well as provide
actionable suggestions and tools to support these initiatives further. This aims
to support academic organisations such as the Deep Learning Indaba, Neuromatch
Academy, the IBRO-Simons Computational Neuroscience Imbizo, Biodiversity Information
Standards (TDWG), Arabs in Neuroscience, FAIRPoints, and OLS (formerly Open Life
Science). This article is a call to action for organisers to reevaluate the impact
and reach of their inclusive practices.
acknowledgement: "We would like to recognise the feedback and ideas shared with us
by all attendees during the\r\nfocus groups that contributed to the development
of this paper. Acknowledgements are given\r\nto Elisee Jafsia, Umar Farouk Ahmad,
Zohra Slim, Mizanur Rahman, Rev. Katie Tupling,\r\nChristopher Emmanuel, Abdalrhman
Mostafa, Pradeep Eranti, Toby Hodges, Avishkar\r\nBhoopchand, and Carolyn Dickson.
We would like to thank our community members and\r\nacknowledge their bravery for
sharing their stories that shaped the narrative of these Ten Simple\r\nRules. The
stories shared with us formed the case studies, and while they are anonymous\r\nfor
privacy and protection reasons, it is these stories that were on our mind during
the entire\r\nprocess and kept us going. We acknowledge the efforts of the organisers
that contribute to the\r\nhighly successful events that are the inspiration for
the ideas presented here: the Deep\r\nLearning Indaba, Neuromatch Academy, the IBRO
Simons Computational Neuroscience\r\nImbizo, and OLS. OLS also supported this project
through their mentorship programme,\r\nOpen Seeds."
article_number: e1011797
article_processing_charge: Yes
article_type: original
author:
- first_name: Siobhan Mackenzie
full_name: Hall, Siobhan Mackenzie
last_name: Hall
- first_name: Daniel
full_name: Kochin, Daniel
last_name: Kochin
- first_name: Carmel
full_name: Carne, Carmel
last_name: Carne
- first_name: Patricia
full_name: Herterich, Patricia
last_name: Herterich
- first_name: Kristen Lenay
full_name: Lewers, Kristen Lenay
last_name: Lewers
- first_name: Mohamed
full_name: Abdelhack, Mohamed
last_name: Abdelhack
- first_name: Arun
full_name: Ramasubramanian, Arun
last_name: Ramasubramanian
- first_name: Juno Felecia
full_name: Michael Alphonse, Juno Felecia
last_name: Michael Alphonse
- first_name: Visotheary
full_name: Ung, Visotheary
last_name: Ung
- first_name: Sara
full_name: El-Gebali, Sara
last_name: El-Gebali
- first_name: Christopher
full_name: Currin, Christopher
id: e8321fc5-3091-11eb-8a53-83f309a11ac9
last_name: Currin
orcid: 0000-0002-4809-5059
- first_name: Esther
full_name: Plomp, Esther
last_name: Plomp
- first_name: Rachel
full_name: Thompson, Rachel
last_name: Thompson
- first_name: Malvika
full_name: Sharan, Malvika
last_name: Sharan
citation:
ama: Hall SM, Kochin D, Carne C, et al. Ten simple rules for pushing boundaries
of inclusion at academic events. PLOS Computational Biology. 2024;20(3).
doi:10.1371/journal.pcbi.1011797
apa: Hall, S. M., Kochin, D., Carne, C., Herterich, P., Lewers, K. L., Abdelhack,
M., … Sharan, M. (2024). Ten simple rules for pushing boundaries of inclusion
at academic events. PLOS Computational Biology. Public Library of Science.
https://doi.org/10.1371/journal.pcbi.1011797
chicago: Hall, Siobhan Mackenzie, Daniel Kochin, Carmel Carne, Patricia Herterich,
Kristen Lenay Lewers, Mohamed Abdelhack, Arun Ramasubramanian, et al. “Ten Simple
Rules for Pushing Boundaries of Inclusion at Academic Events.” PLOS Computational
Biology. Public Library of Science, 2024. https://doi.org/10.1371/journal.pcbi.1011797.
ieee: S. M. Hall et al., “Ten simple rules for pushing boundaries of inclusion
at academic events,” PLOS Computational Biology, vol. 20, no. 3. Public
Library of Science, 2024.
ista: Hall SM, Kochin D, Carne C, Herterich P, Lewers KL, Abdelhack M, Ramasubramanian
A, Michael Alphonse JF, Ung V, El-Gebali S, Currin C, Plomp E, Thompson R, Sharan
M. 2024. Ten simple rules for pushing boundaries of inclusion at academic events.
PLOS Computational Biology. 20(3), e1011797.
mla: Hall, Siobhan Mackenzie, et al. “Ten Simple Rules for Pushing Boundaries of
Inclusion at Academic Events.” PLOS Computational Biology, vol. 20, no.
3, e1011797, Public Library of Science, 2024, doi:10.1371/journal.pcbi.1011797.
short: S.M. Hall, D. Kochin, C. Carne, P. Herterich, K.L. Lewers, M. Abdelhack,
A. Ramasubramanian, J.F. Michael Alphonse, V. Ung, S. El-Gebali, C. Currin, E.
Plomp, R. Thompson, M. Sharan, PLOS Computational Biology 20 (2024).
date_created: 2024-04-02T11:37:32Z
date_published: 2024-03-01T00:00:00Z
date_updated: 2025-09-04T13:24:19Z
day: '01'
ddc:
- '000'
department:
- _id: TiVo
doi: 10.1371/journal.pcbi.1011797
external_id:
isi:
- '001181690200005'
pmid:
- '38427633'
file:
- access_level: open_access
checksum: 1f0f837c5b4341f54f6347370ed8c1b7
content_type: application/pdf
creator: dernst
date_created: 2024-04-03T13:29:36Z
date_updated: 2024-04-03T13:29:36Z
file_id: '15289'
file_name: 2024_PloS_Hall.pdf
file_size: 858521
relation: main_file
success: 1
file_date_updated: 2024-04-03T13:29:36Z
fulldoi: https://doi.org/10.1371/journal.pcbi.1011797
has_accepted_license: '1'
intvolume: ' 20'
isi: 1
issue: '3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
publication: PLOS Computational Biology
publication_identifier:
issn:
- 1553-7358
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Ten simple rules for pushing boundaries of inclusion at academic events
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 20
year: '2024'
...
---
DOAJ_listed: '1'
OA_type: gold
_id: '15295'
abstract:
- lang: eng
text: "Background: Benzodiazepines and antidepressants are effective agents for
the treatment of generalized anxiety disorder (GAD), with the HAM-A frequently
used as a primary outcome measure. The GAD literature is inconsistent regarding
which medications are more effective for somatic versus psychic symptoms of GAD,
and treatment guidelines do not advocate for prescribing based on subtype. This
meta-analysis aimed to determine whether benzodiazepines and antidepressants have
a differential impact on the somatic versus psychic subscales of the HAM-A in
GAD.\r\n\r\nMethods: An electronic search was undertaken for randomized controlled
trials of either benzodiazepines or antidepressants for GAD that reported treatment
response using the HAM-A subscales. Data were extracted by independent reviewers.
A random effects assessment of weighted mean difference with 95% confidence intervals
and subgroup difference was applied. All analysis was done on SPSS 26. An assessment
of bias, and of quality of evidence was performed.\r\n\r\nResults: 24 randomized
controlled trials met the inclusion criteria: 18 antidepressant trials, 5 benzodiazepine
trials and 1 of both. 14 studies were assessed as having between some and high
risk of bias, while 10 were assessed as having low risk of bias. Benzodiazepines
(WMD of 1.81 [CI 1.03, 2.58]) were significantly more effective than antidepressants
(WMD of 0.83 [CI 0.64, 1.02]) for reducing somatic symptoms of GAD (Chi2 = 5.81,
p = 0.02), and were also more effective (WMD of 2.46 [CI 1.83, 3.09]) in reducing
psychic symptoms than antidepressants (WMD of 1.83 [CI 1.55, 2.10]), although
this comparison did not reach statistical significance (Chi2 = 3.31, p = 0.07).\r\n\r\nConclusion:
The finding that benzodiazepines were significantly more effective than antidepressants
for somatic symptoms needs to be weighed up against potential benefits of antidepressants
over benzodiazepines. It may be useful for future treatment guidelines for GAD
to explicitly consider symptom subtype."
article_number: '152479'
article_processing_charge: Yes
article_type: original
author:
- first_name: Chad
full_name: Beyer, Chad
last_name: Beyer
- first_name: Christopher
full_name: Currin, Christopher
id: e8321fc5-3091-11eb-8a53-83f309a11ac9
last_name: Currin
orcid: 0000-0002-4809-5059
- first_name: Taryn
full_name: Williams, Taryn
last_name: Williams
- first_name: Dan J.
full_name: Stein, Dan J.
last_name: Stein
citation:
ama: Beyer C, Currin C, Williams T, Stein DJ. Meta-analysis of the comparative efficacy
of benzodiazepines and antidepressants for psychic versus somatic symptoms of
generalized anxiety disorder. Comprehensive Psychiatry. 2024;132. doi:10.1016/j.comppsych.2024.152479
apa: Beyer, C., Currin, C., Williams, T., & Stein, D. J. (2024). Meta-analysis
of the comparative efficacy of benzodiazepines and antidepressants for psychic
versus somatic symptoms of generalized anxiety disorder. Comprehensive Psychiatry.
Elsevier. https://doi.org/10.1016/j.comppsych.2024.152479
chicago: Beyer, Chad, Christopher Currin, Taryn Williams, and Dan J. Stein. “Meta-Analysis
of the Comparative Efficacy of Benzodiazepines and Antidepressants for Psychic
versus Somatic Symptoms of Generalized Anxiety Disorder.” Comprehensive Psychiatry.
Elsevier, 2024. https://doi.org/10.1016/j.comppsych.2024.152479.
ieee: C. Beyer, C. Currin, T. Williams, and D. J. Stein, “Meta-analysis of the comparative
efficacy of benzodiazepines and antidepressants for psychic versus somatic symptoms
of generalized anxiety disorder,” Comprehensive Psychiatry, vol. 132. Elsevier,
2024.
ista: Beyer C, Currin C, Williams T, Stein DJ. 2024. Meta-analysis of the comparative
efficacy of benzodiazepines and antidepressants for psychic versus somatic symptoms
of generalized anxiety disorder. Comprehensive Psychiatry. 132, 152479.
mla: Beyer, Chad, et al. “Meta-Analysis of the Comparative Efficacy of Benzodiazepines
and Antidepressants for Psychic versus Somatic Symptoms of Generalized Anxiety
Disorder.” Comprehensive Psychiatry, vol. 132, 152479, Elsevier, 2024,
doi:10.1016/j.comppsych.2024.152479.
short: C. Beyer, C. Currin, T. Williams, D.J. Stein, Comprehensive Psychiatry 132
(2024).
date_created: 2024-04-07T22:00:55Z
date_published: 2024-07-01T00:00:00Z
date_updated: 2025-09-04T13:30:08Z
day: '01'
ddc:
- '570'
department:
- _id: TiVo
doi: 10.1016/j.comppsych.2024.152479
external_id:
isi:
- '001221136000001'
pmid:
- '38564872'
file:
- access_level: open_access
checksum: aadb57448b5f170761ed72cbcc31ba16
content_type: application/pdf
creator: dernst
date_created: 2025-01-13T10:47:20Z
date_updated: 2025-01-13T10:47:20Z
file_id: '18839'
file_name: 2024_ComprehensivePsychiatry_Beyer.pdf
file_size: 2874425
relation: main_file
success: 1
file_date_updated: 2025-01-13T10:47:20Z
fulldoi: https://doi.org/10.1016/j.comppsych.2024.152479
has_accepted_license: '1'
intvolume: ' 132'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
publication: Comprehensive Psychiatry
publication_identifier:
eissn:
- 1532-8384
issn:
- 0010-440X
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Meta-analysis of the comparative efficacy of benzodiazepines and antidepressants
for psychic versus somatic symptoms of generalized anxiety disorder
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 132
year: '2024'
...
---
_id: '15296'
abstract:
- lang: eng
text: In this paper we build a constructive algorithm that returns a rectifiable
curve that connects two points in a weakly convex set in a Hilbert space. We have
proven that this algorithm converges and obtained an estimate on the curve’s length
and compare the length of the curve obtained to known results.
article_number: '080002'
article_processing_charge: No
author:
- first_name: Mariana
full_name: Lopushanski, Mariana
last_name: Lopushanski
- first_name: Grigory
full_name: Ivanov, Grigory
id: 87744F66-5C6F-11EA-AFE0-D16B3DDC885E
last_name: Ivanov
citation:
ama: 'Lopushanski M, Ivanov G. A constructive algorithm for building rectifiable
curves in weakly convex sets. In: AIP Conference Proceedings. Vol 3030.
AIP Publishing; 2024. doi:10.1063/5.0195908'
apa: 'Lopushanski, M., & Ivanov, G. (2024). A constructive algorithm for building
rectifiable curves in weakly convex sets. In AIP Conference Proceedings
(Vol. 3030). Virtual: AIP Publishing. https://doi.org/10.1063/5.0195908'
chicago: Lopushanski, Mariana, and Grigory Ivanov. “A Constructive Algorithm for
Building Rectifiable Curves in Weakly Convex Sets.” In AIP Conference Proceedings,
Vol. 3030. AIP Publishing, 2024. https://doi.org/10.1063/5.0195908.
ieee: M. Lopushanski and G. Ivanov, “A constructive algorithm for building rectifiable
curves in weakly convex sets,” in AIP Conference Proceedings, Virtual,
2024, vol. 3030, no. 1.
ista: 'Lopushanski M, Ivanov G. 2024. A constructive algorithm for building rectifiable
curves in weakly convex sets. AIP Conference Proceedings. ICCMSE: International
Conference of Computational Methods in Sciences and Engiineering vol. 3030, 080002.'
mla: Lopushanski, Mariana, and Grigory Ivanov. “A Constructive Algorithm for Building
Rectifiable Curves in Weakly Convex Sets.” AIP Conference Proceedings,
vol. 3030, no. 1, 080002, AIP Publishing, 2024, doi:10.1063/5.0195908.
short: M. Lopushanski, G. Ivanov, in:, AIP Conference Proceedings, AIP Publishing,
2024.
conference:
end_date: 2022-10-29
location: Virtual
name: 'ICCMSE: International Conference of Computational Methods in Sciences and
Engiineering'
start_date: 2022-10-26
date_created: 2024-04-07T22:00:55Z
date_published: 2024-03-14T00:00:00Z
date_updated: 2024-04-08T07:40:53Z
day: '14'
department:
- _id: UlWa
doi: 10.1063/5.0195908
fulldoi: https://doi.org/10.1063/5.0195908
intvolume: ' 3030'
issue: '1'
language:
- iso: eng
month: '03'
oa_version: None
publication: AIP Conference Proceedings
publication_identifier:
eissn:
- 1551-7616
issn:
- 0094-243X
publication_status: published
publisher: AIP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: A constructive algorithm for building rectifiable curves in weakly convex sets
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3030
year: '2024'
...
---
_id: '15301'
abstract:
- lang: eng
text: Plant morphogenesis relies exclusively on oriented cell expansion and division.
Nonetheless, the mechanism(s) determining division plane orientation remain elusive.
Here, we studied tissue healing after laser-assisted wounding in roots of Arabidopsis
thaliana and uncovered how mechanical forces stabilize and reorient the microtubule
cytoskeleton for the orientation of cell division. We identified that root tissue
functions as an interconnected cell matrix, with a radial gradient of tissue extendibility
causing predictable tissue deformation after wounding. This deformation causes
instant redirection of expansion in the surrounding cells and reorientation of
microtubule arrays, ultimately predicting cell division orientation. Microtubules
are destabilized under low tension, whereas stretching of cells, either through
wounding or external aspiration, immediately induces their polymerization. The
higher microtubule abundance in the stretched cell parts leads to the reorientation
of microtubule arrays and, ultimately, informs cell division planes. This provides
a long-sought mechanism for flexible re-arrangement of cell divisions by mechanical
forces for tissue reconstruction and plant architecture.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: We are thankful to Simon Gilroy, Alexander Jones, and Lieven De Veylder
for sharing published material. We thank the Imaging & Optics and Life Science Facilities
at IST Austria, the Biooptics facility at GMI, and the Cellular Imaging Facility
at DBMV UNIL for providing invaluable assistance. The research leading to these
results has received funding from the European Research Council under the European
Union's Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no. 742985,
from the FWF under the stand-alone grant P29988, and from EMBO (ALTF 253-2023).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Lukas
full_name: Hörmayer, Lukas
id: 2EEE7A2A-F248-11E8-B48F-1D18A9856A87
last_name: Hörmayer
orcid: 0000-0001-8295-2926
- first_name: Juan C
full_name: Montesinos López, Juan C
id: 310A8E3E-F248-11E8-B48F-1D18A9856A87
last_name: Montesinos López
orcid: 0000-0001-9179-6099
- first_name: N
full_name: Trozzi, N
last_name: Trozzi
- first_name: Leonhard
full_name: Spona, Leonhard
id: b52391fb-f636-11ee-939c-8a8c47552e8a
last_name: Spona
- first_name: Saiko
full_name: Yoshida, Saiko
id: 2E46069C-F248-11E8-B48F-1D18A9856A87
last_name: Yoshida
- first_name: Petra
full_name: Marhavá, Petra
id: 44E59624-F248-11E8-B48F-1D18A9856A87
last_name: Marhavá
- first_name: Silvia
full_name: Caballero Mancebo, Silvia
id: 2F1E1758-F248-11E8-B48F-1D18A9856A87
last_name: Caballero Mancebo
orcid: 0000-0002-5223-3346
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Y
full_name: Dagdas, Y
last_name: Dagdas
- first_name: M
full_name: Majda, M
last_name: Majda
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Hörmayer L, Montesinos López JC, Trozzi N, et al. Mechanical forces in plant
tissue matrix orient cell divisions via microtubule stabilization. Developmental
Cell. 2024;59(10):1333-1344.e4. doi:10.1016/j.devcel.2024.03.009
apa: Hörmayer, L., Montesinos López, J. C., Trozzi, N., Spona, L., Yoshida, S.,
Marhavá, P., … Friml, J. (2024). Mechanical forces in plant tissue matrix orient
cell divisions via microtubule stabilization. Developmental Cell. Elsevier.
https://doi.org/10.1016/j.devcel.2024.03.009
chicago: Hörmayer, Lukas, Juan C Montesinos López, N Trozzi, Leonhard Spona, Saiko
Yoshida, Petra Marhavá, Silvia Caballero Mancebo, et al. “Mechanical Forces in
Plant Tissue Matrix Orient Cell Divisions via Microtubule Stabilization.” Developmental
Cell. Elsevier, 2024. https://doi.org/10.1016/j.devcel.2024.03.009.
ieee: L. Hörmayer et al., “Mechanical forces in plant tissue matrix orient
cell divisions via microtubule stabilization,” Developmental Cell, vol.
59, no. 10. Elsevier, p. 1333–1344.e4, 2024.
ista: Hörmayer L, Montesinos López JC, Trozzi N, Spona L, Yoshida S, Marhavá P,
Caballero Mancebo S, Benková E, Heisenberg C-PJ, Dagdas Y, Majda M, Friml J. 2024.
Mechanical forces in plant tissue matrix orient cell divisions via microtubule
stabilization. Developmental Cell. 59(10), 1333–1344.e4.
mla: Hörmayer, Lukas, et al. “Mechanical Forces in Plant Tissue Matrix Orient Cell
Divisions via Microtubule Stabilization.” Developmental Cell, vol. 59,
no. 10, Elsevier, 2024, p. 1333–1344.e4, doi:10.1016/j.devcel.2024.03.009.
short: L. Hörmayer, J.C. Montesinos López, N. Trozzi, L. Spona, S. Yoshida, P. Marhavá,
S. Caballero Mancebo, E. Benková, C.-P.J. Heisenberg, Y. Dagdas, M. Majda, J.
Friml, Developmental Cell 59 (2024) 1333–1344.e4.
corr_author: '1'
date_created: 2024-04-08T12:07:57Z
date_published: 2024-05-20T00:00:00Z
date_updated: 2025-09-04T13:32:08Z
day: '20'
ddc:
- '570'
department:
- _id: JiFr
- _id: EvBe
- _id: CaHe
doi: 10.1016/j.devcel.2024.03.009
ec_funded: 1
external_id:
isi:
- '001301584600001'
pmid:
- '38579717'
file:
- access_level: open_access
checksum: 22b374fb50a40d380b7686c84258d271
content_type: application/pdf
creator: dernst
date_created: 2024-08-20T11:22:16Z
date_updated: 2024-08-20T11:22:16Z
file_id: '17452'
file_name: 2024_DevelopmentalCell_Hoermayer.pdf
file_size: 5195262
relation: main_file
success: 1
file_date_updated: 2024-08-20T11:22:16Z
fulldoi: https://doi.org/10.1016/j.devcel.2024.03.009
has_accepted_license: '1'
intvolume: ' 59'
isi: 1
issue: '10'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 1333-1344.e4
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 262EF96E-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P29988
name: RNA-directed DNA methylation in plant development
publication: Developmental Cell
publication_identifier:
eissn:
- 1878-1551
issn:
- 1534-5807
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/how-plants-heal-wounds/
scopus_import: '1'
status: public
title: Mechanical forces in plant tissue matrix orient cell divisions via microtubule
stabilization
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 59
year: '2024'
...
---
_id: '15314'
abstract:
- lang: eng
text: Development of electroactive materials exhibiting high performance with superior
stability is crucial in the field of supercapacitors and battery research. We
report on synthesis of highly stable composite of semi-polycrystalline polyaniline
and graphene (SPani-graphene) and its application in supercapacitor electrodes.
The electrochemical behavior and device performance of the electrodes were investigated
through cyclic voltammetry (CV), galvanostatic charge-discharge GCD) and electrochemical
impedance spectroscopy (EIS) in a 3-electrode and a 2-electrode (device) cell
configurations, repectively. The cell specific capacitance (Cell Csp) achieved
from the 2-electrode symmetric cell configuration was 525.5 F g−1 at 0.1 A g−1
using polymer gel electrolyte (PGE). The PGE in this work is xanthan gum jellied
in 1 M aq. Na2SO4. The maximum energy density and power density achieved from
the device was 46.7 Wh kg−1 and 16.16 kW kg−1, respectively, at 0.4 A g−1. Furthermore,
the device exhibits an excellent retention of cell specific capacitance and coulombic
efficiency of 97 % and 94 %, respectively, over 10,000 continuous GCD cycles,
indicating an excellent rate capability as well as a promising power management.
To investigate the material's electrochemical durability, a detailed EIS study
has been carried out using both, 3-electrode, and 2-electrode cell configurations,
before and after long cycling test (over 10,000 continuous GCD cycles). Our thorough
experimentation delivers satisfactory results and has been explained in detail
in the manuscript. Hereby, we propose that the EIS technique can be adopted for
investigating materials' electrochemical stability, in addition to long CV and
GCD cycles in the field of supercapacitors and battery research.
acknowledgement: "This work was supported by Korea Institute of Energy Technology
Evaluation and Planning (KETEP); and Ministry of Trade, Industry & Energy (MOTIE),
Republic of Korea (Grant No. \r\n20210501010020)."
article_number: '111464'
article_processing_charge: No
article_type: original
author:
- first_name: Neelima
full_name: Mahato, Neelima
last_name: Mahato
- first_name: Saurabh
full_name: Singh, Saurabh
id: 12d625da-9cb3-11ed-9667-af09d37d3f0a
last_name: Singh
orcid: 0000-0003-2209-5269
- first_name: T. V.M.
full_name: Sreekanth, T. V.M.
last_name: Sreekanth
- first_name: Kisoo
full_name: Yoo, Kisoo
last_name: Yoo
- first_name: Jonghoon
full_name: Kim, Jonghoon
last_name: Kim
citation:
ama: 'Mahato N, Singh S, Sreekanth TVM, Yoo K, Kim J. Polycrystalline phases engineered
in-situ in polyaniline-graphene composite evoluting an exceptional stability and
high charge storage capacity: An EIS investigative approach to evaluate material’s
stability. Journal of Energy Storage. 2024;88. doi:10.1016/j.est.2024.111464'
apa: 'Mahato, N., Singh, S., Sreekanth, T. V. M., Yoo, K., & Kim, J. (2024).
Polycrystalline phases engineered in-situ in polyaniline-graphene composite evoluting
an exceptional stability and high charge storage capacity: An EIS investigative
approach to evaluate material’s stability. Journal of Energy Storage. Elsevier.
https://doi.org/10.1016/j.est.2024.111464'
chicago: 'Mahato, Neelima, Saurabh Singh, T. V.M. Sreekanth, Kisoo Yoo, and Jonghoon
Kim. “Polycrystalline Phases Engineered In-Situ in Polyaniline-Graphene Composite
Evoluting an Exceptional Stability and High Charge Storage Capacity: An EIS Investigative
Approach to Evaluate Material’s Stability.” Journal of Energy Storage.
Elsevier, 2024. https://doi.org/10.1016/j.est.2024.111464.'
ieee: 'N. Mahato, S. Singh, T. V. M. Sreekanth, K. Yoo, and J. Kim, “Polycrystalline
phases engineered in-situ in polyaniline-graphene composite evoluting an exceptional
stability and high charge storage capacity: An EIS investigative approach to evaluate
material’s stability,” Journal of Energy Storage, vol. 88. Elsevier, 2024.'
ista: 'Mahato N, Singh S, Sreekanth TVM, Yoo K, Kim J. 2024. Polycrystalline phases
engineered in-situ in polyaniline-graphene composite evoluting an exceptional
stability and high charge storage capacity: An EIS investigative approach to evaluate
material’s stability. Journal of Energy Storage. 88, 111464.'
mla: 'Mahato, Neelima, et al. “Polycrystalline Phases Engineered In-Situ in Polyaniline-Graphene
Composite Evoluting an Exceptional Stability and High Charge Storage Capacity:
An EIS Investigative Approach to Evaluate Material’s Stability.” Journal of
Energy Storage, vol. 88, 111464, Elsevier, 2024, doi:10.1016/j.est.2024.111464.'
short: N. Mahato, S. Singh, T.V.M. Sreekanth, K. Yoo, J. Kim, Journal of Energy
Storage 88 (2024).
date_created: 2024-04-14T22:01:01Z
date_published: 2024-05-30T00:00:00Z
date_updated: 2025-09-04T13:38:27Z
day: '30'
department:
- _id: MaIb
doi: 10.1016/j.est.2024.111464
external_id:
isi:
- '001287584100001'
fulldoi: https://doi.org/10.1016/j.est.2024.111464
intvolume: ' 88'
isi: 1
language:
- iso: eng
month: '05'
oa_version: None
publication: Journal of Energy Storage
publication_identifier:
eissn:
- 2352-152X
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Polycrystalline phases engineered in-situ in polyaniline-graphene composite
evoluting an exceptional stability and high charge storage capacity: An EIS investigative
approach to evaluate material''s stability'
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 88
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '15316'
abstract:
- lang: eng
text: Genomic DNA that resides in the nuclei of mammalian neurons can be as old
as the organism itself. The life span of nuclear RNAs, which are critical for
proper chromatin architecture and transcription regulation, has not been determined
in adult tissues. In this work, we identified and characterized nuclear RNAs that
do not turn over for at least 2 years in a subset of postnatally born cells in
the mouse brain. These long-lived RNAs were stably retained in nuclei in a neural
cell type–specific manner and were required for the maintenance of heterochromatin.
Thus, the life span of neural cells may depend on both the molecular longevity
of DNA for the storage of genetic information and also the extreme stability of
RNA for the functional organization of chromatin.
acknowledgement: 'European Research Council: ERC-2018-STG, 804468 EAGER; European
Research Council: ERC-2023-COG, 101125034 NEUTIME; Deutsche Forschungsgemeinschaft:
TO1347/4-1; Boehringer Ingelheim Stiftung; Deutsches Zentrum für Neurodegenerative
Erkrankungen'
article_processing_charge: No
article_type: original
author:
- first_name: Sara
full_name: Zocher, Sara
last_name: Zocher
- first_name: Asako
full_name: Mccloskey, Asako
last_name: Mccloskey
- first_name: Anne
full_name: Karasinsky, Anne
last_name: Karasinsky
- first_name: Roberta
full_name: Schulte, Roberta
last_name: Schulte
- first_name: Ulrike
full_name: Friedrich, Ulrike
last_name: Friedrich
- first_name: Mathias
full_name: Lesche, Mathias
last_name: Lesche
- first_name: Nicole
full_name: Rund, Nicole
last_name: Rund
- first_name: Fred H.
full_name: Gage, Fred H.
last_name: Gage
- first_name: Martin W
full_name: Hetzer, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: Hetzer
orcid: 0000-0002-2111-992X
- first_name: Tomohisa
full_name: Toda, Tomohisa
last_name: Toda
citation:
ama: Zocher S, Mccloskey A, Karasinsky A, et al. Lifelong persistence of nuclear
RNAs in the mouse brain. Science. 2024;384(6691):53-59. doi:10.1126/science.adf3481
apa: Zocher, S., Mccloskey, A., Karasinsky, A., Schulte, R., Friedrich, U., Lesche,
M., … Toda, T. (2024). Lifelong persistence of nuclear RNAs in the mouse brain.
Science. AAAS. https://doi.org/10.1126/science.adf3481
chicago: Zocher, Sara, Asako Mccloskey, Anne Karasinsky, Roberta Schulte, Ulrike
Friedrich, Mathias Lesche, Nicole Rund, Fred H. Gage, Martin Hetzer, and Tomohisa
Toda. “Lifelong Persistence of Nuclear RNAs in the Mouse Brain.” Science.
AAAS, 2024. https://doi.org/10.1126/science.adf3481.
ieee: S. Zocher et al., “Lifelong persistence of nuclear RNAs in the mouse
brain,” Science, vol. 384, no. 6691. AAAS, pp. 53–59, 2024.
ista: Zocher S, Mccloskey A, Karasinsky A, Schulte R, Friedrich U, Lesche M, Rund
N, Gage FH, Hetzer M, Toda T. 2024. Lifelong persistence of nuclear RNAs in the
mouse brain. Science. 384(6691), 53–59.
mla: Zocher, Sara, et al. “Lifelong Persistence of Nuclear RNAs in the Mouse Brain.”
Science, vol. 384, no. 6691, AAAS, 2024, pp. 53–59, doi:10.1126/science.adf3481.
short: S. Zocher, A. Mccloskey, A. Karasinsky, R. Schulte, U. Friedrich, M. Lesche,
N. Rund, F.H. Gage, M. Hetzer, T. Toda, Science 384 (2024) 53–59.
corr_author: '1'
date_created: 2024-04-14T22:01:01Z
date_published: 2024-04-04T00:00:00Z
date_updated: 2025-09-04T13:39:58Z
day: '04'
department:
- _id: MaHe
doi: 10.1126/science.adf3481
external_id:
isi:
- '001253335100031'
pmid:
- '38574132'
fulldoi: https://doi.org/10.1126/science.adf3481
intvolume: ' 384'
isi: 1
issue: '6691'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615865
month: '04'
oa: 1
oa_version: Submitted Version
page: 53-59
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: AAAS
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/nerve-cells-old-at-heart/
scopus_import: '1'
status: public
title: Lifelong persistence of nuclear RNAs in the mouse brain
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 384
year: '2024'
...
---
_id: '15319'
abstract:
- lang: eng
text: Exocyst component of 70-kDa (EXO70) proteins are constituents of the exocyst
complex implicated in vesicle tethering during exocytosis. MILDEW RESISTANCE LOCUS
O (MLO) proteins are plant-specific calcium channels and some MLO isoforms enable
fungal powdery mildew pathogenesis. We here detected an unexpected phenotypic
overlap of Arabidopsis thaliana exo70H4 and mlo2 mlo6 mlo12 triple mutant plants
regarding the biogenesis of leaf trichome secondary cell walls. Biochemical and
Fourier transform infrared spectroscopic analyses corroborated deficiencies in
the composition of trichome cell walls in these mutants. Transgenic lines expressing
fluorophore-tagged EXO70H4 and MLO exhibited extensive colocalization of these
proteins. Furthermore, mCherry-EXO70H4 mislocalized in trichomes of the mlo triple
mutant and, vice versa, MLO6-GFP mislocalized in trichomes of the exo70H4 mutant.
Expression of GFP-marked PMR4 callose synthase, a known cargo of EXO70H4-dependent
exocytosis, revealed reduced cell wall delivery of GFP-PMR4 in trichomes of mlo
triple mutant plants. In vivo protein–protein interaction assays in plant and
yeast cells uncovered isoform-preferential interactions between EXO70.2 subfamily
members and MLO proteins. Finally, exo70H4 and mlo6 mutants, when combined, showed
synergistically enhanced resistance to powdery mildew attack. Taken together,
our data point to an isoform-specific interplay of EXO70 and MLO proteins in the
modulation of trichome cell wall biogenesis and powdery mildew susceptibility.
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Jan W.
full_name: Huebbers, Jan W.
last_name: Huebbers
- first_name: George A.
full_name: Caldarescu, George A.
last_name: Caldarescu
- first_name: Zdeňka
full_name: Kubátová, Zdeňka
last_name: Kubátová
- first_name: Peter
full_name: Sabol, Peter
last_name: Sabol
- first_name: Sophie C.J.
full_name: Levecque, Sophie C.J.
last_name: Levecque
- first_name: Hannah
full_name: Kuhn, Hannah
last_name: Kuhn
- first_name: Ivan
full_name: Kulich, Ivan
id: 57a1567c-8314-11eb-9063-c9ddc3451a54
last_name: Kulich
- first_name: Anja
full_name: Reinstädler, Anja
last_name: Reinstädler
- first_name: Kim
full_name: Büttgen, Kim
last_name: Büttgen
- first_name: Alba
full_name: Manga-Robles, Alba
last_name: Manga-Robles
- first_name: Hugo
full_name: Mélida, Hugo
last_name: Mélida
- first_name: Markus
full_name: Pauly, Markus
last_name: Pauly
- first_name: Ralph
full_name: Panstruga, Ralph
last_name: Panstruga
- first_name: Viktor
full_name: Žárský, Viktor
last_name: Žárský
citation:
ama: Huebbers JW, Caldarescu GA, Kubátová Z, et al. Interplay of EXO70 and MLO proteins
modulates trichome cell wall composition and susceptibility to powdery mildew.
Plant Cell. 2024;36(4):1007-1035. doi:10.1093/plcell/koad319
apa: Huebbers, J. W., Caldarescu, G. A., Kubátová, Z., Sabol, P., Levecque, S. C.
J., Kuhn, H., … Žárský, V. (2024). Interplay of EXO70 and MLO proteins modulates
trichome cell wall composition and susceptibility to powdery mildew. Plant
Cell. Oxford University Press. https://doi.org/10.1093/plcell/koad319
chicago: Huebbers, Jan W., George A. Caldarescu, Zdeňka Kubátová, Peter Sabol, Sophie
C.J. Levecque, Hannah Kuhn, Ivan Kulich, et al. “Interplay of EXO70 and MLO Proteins
Modulates Trichome Cell Wall Composition and Susceptibility to Powdery Mildew.”
Plant Cell. Oxford University Press, 2024. https://doi.org/10.1093/plcell/koad319.
ieee: J. W. Huebbers et al., “Interplay of EXO70 and MLO proteins modulates
trichome cell wall composition and susceptibility to powdery mildew,” Plant
Cell, vol. 36, no. 4. Oxford University Press, pp. 1007–1035, 2024.
ista: Huebbers JW, Caldarescu GA, Kubátová Z, Sabol P, Levecque SCJ, Kuhn H, Kulich
I, Reinstädler A, Büttgen K, Manga-Robles A, Mélida H, Pauly M, Panstruga R, Žárský
V. 2024. Interplay of EXO70 and MLO proteins modulates trichome cell wall composition
and susceptibility to powdery mildew. Plant Cell. 36(4), 1007–1035.
mla: Huebbers, Jan W., et al. “Interplay of EXO70 and MLO Proteins Modulates Trichome
Cell Wall Composition and Susceptibility to Powdery Mildew.” Plant Cell,
vol. 36, no. 4, Oxford University Press, 2024, pp. 1007–35, doi:10.1093/plcell/koad319.
short: J.W. Huebbers, G.A. Caldarescu, Z. Kubátová, P. Sabol, S.C.J. Levecque, H.
Kuhn, I. Kulich, A. Reinstädler, K. Büttgen, A. Manga-Robles, H. Mélida, M. Pauly,
R. Panstruga, V. Žárský, Plant Cell 36 (2024) 1007–1035.
date_created: 2024-04-14T22:01:02Z
date_published: 2024-04-01T00:00:00Z
date_updated: 2024-04-17T07:01:21Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1093/plcell/koad319
external_id:
pmid:
- '38124479'
file:
- access_level: open_access
checksum: f9994d2e4748feec24c992b39871aba1
content_type: application/pdf
creator: dernst
date_created: 2024-04-17T06:57:54Z
date_updated: 2024-04-17T06:57:54Z
file_id: '15326'
file_name: 2024_PlantCell_Huebbers.pdf
file_size: 2866098
relation: main_file
success: 1
file_date_updated: 2024-04-17T06:57:54Z
fulldoi: https://doi.org/10.1093/plcell/koad319
has_accepted_license: '1'
intvolume: ' 36'
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 1007-1035
pmid: 1
publication: Plant Cell
publication_identifier:
eissn:
- 1532-298X
issn:
- 1040-4651
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interplay of EXO70 and MLO proteins modulates trichome cell wall composition
and susceptibility to powdery mildew
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 36
year: '2024'
...
---
_id: '15321'
abstract:
- lang: eng
text: Boolean Networks (BNs) are widely used as a modeling formalism in several
domains, notably systems biology and computer science. A fundamental problem in
BN analysis is the enumeration of trap spaces, which are hypercubes in the state
space that cannot be escaped once entered. Several methods have been proposed
for enumerating trap spaces, however they often suffer from scalability and efficiency
issues, particularly for large and complex models. To our knowledge, the most
efficient and recent methods for the trap space enumeration all rely on Answer
Set Programming (ASP), which has been widely applied to the analysis of BNs. Motivated
by these considerations, our work proposes a new method for enumerating trap spaces
in BNs using ASP. We evaluate the method on a mix of 250+ real-world and 400+
randomly generated BNs, showing that it enables analysis of models beyond the
capabilities of existing tools (namely pyboolnet, mpbn, trappist, and trapmvn).
acknowledgement: This work was supported by Institut Carnot STAR, Marseille, France
and by the European Union’s Horizon 2020 research and innovation programme under
the Marie Skłodowska-Curie Grant Agreement No. 101034413.
article_processing_charge: No
author:
- first_name: Giang
full_name: Trinh, Giang
last_name: Trinh
- first_name: Belaid
full_name: Benhamou, Belaid
last_name: Benhamou
- first_name: Samuel
full_name: Pastva, Samuel
id: 07c5ea74-f61c-11ec-a664-aa7c5d957b2b
last_name: Pastva
orcid: 0000-0003-1993-0331
- first_name: Sylvain
full_name: Soliman, Sylvain
last_name: Soliman
citation:
ama: 'Trinh G, Benhamou B, Pastva S, Soliman S. Scalable enumeration of trap spaces
in boolean networks via answer set programming. In: Proceedings of the 38th
AAAI Conference on Artificial Intelligence. Vol 38. Association for the Advancement
of Artificial Intelligence; 2024:10714-10722. doi:10.1609/aaai.v38i9.28943'
apa: Trinh, G., Benhamou, B., Pastva, S., & Soliman, S. (2024). Scalable enumeration
of trap spaces in boolean networks via answer set programming. In Proceedings
of the 38th AAAI Conference on Artificial Intelligence (Vol. 38, pp. 10714–10722).
Association for the Advancement of Artificial Intelligence. https://doi.org/10.1609/aaai.v38i9.28943
chicago: Trinh, Giang, Belaid Benhamou, Samuel Pastva, and Sylvain Soliman. “Scalable
Enumeration of Trap Spaces in Boolean Networks via Answer Set Programming.” In
Proceedings of the 38th AAAI Conference on Artificial Intelligence, 38:10714–22.
Association for the Advancement of Artificial Intelligence, 2024. https://doi.org/10.1609/aaai.v38i9.28943.
ieee: G. Trinh, B. Benhamou, S. Pastva, and S. Soliman, “Scalable enumeration of
trap spaces in boolean networks via answer set programming,” in Proceedings
of the 38th AAAI Conference on Artificial Intelligence, 2024, vol. 38, no.
9, pp. 10714–10722.
ista: Trinh G, Benhamou B, Pastva S, Soliman S. 2024. Scalable enumeration of trap
spaces in boolean networks via answer set programming. Proceedings of the 38th
AAAI Conference on Artificial Intelligence. vol. 38, 10714–10722.
mla: Trinh, Giang, et al. “Scalable Enumeration of Trap Spaces in Boolean Networks
via Answer Set Programming.” Proceedings of the 38th AAAI Conference on Artificial
Intelligence, vol. 38, no. 9, Association for the Advancement of Artificial
Intelligence, 2024, pp. 10714–22, doi:10.1609/aaai.v38i9.28943.
short: G. Trinh, B. Benhamou, S. Pastva, S. Soliman, in:, Proceedings of the 38th
AAAI Conference on Artificial Intelligence, Association for the Advancement of
Artificial Intelligence, 2024, pp. 10714–10722.
date_created: 2024-04-14T22:01:02Z
date_published: 2024-03-25T00:00:00Z
date_updated: 2026-06-18T17:48:08Z
day: '25'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1609/aaai.v38i9.28943
ec_funded: 1
fulldoi: https://doi.org/10.1609/aaai.v38i9.28943
intvolume: ' 38'
issue: '9'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://amu.hal.science/hal-04523118/
month: '03'
oa: 1
oa_version: Published Version
page: 10714-10722
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: Proceedings of the 38th AAAI Conference on Artificial Intelligence
publication_identifier:
eissn:
- 2374-3468
isbn:
- '1577358872'
issn:
- 2159-5399
publication_status: published
publisher: Association for the Advancement of Artificial Intelligence
quality_controlled: '1'
scopus_import: '1'
status: public
title: Scalable enumeration of trap spaces in boolean networks via answer set programming
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 38
year: '2024'
...
---
OA_place: publisher
OA_type: hybrid
_id: '15330'
abstract:
- lang: eng
text: Clathrin-mediated endocytosis (CME) is vital for the regulation of plant growth
and development by controlling plasma membrane protein composition and cargo uptake.
CME relies on the precise recruitment of regulators for vesicle maturation and
release. Homologues of components of mammalian vesicle scission are strong candidates
to be part of the scission machinery in plants, but the precise roles of these
proteins in this process are not fully understood. Here, we characterised the
roles of Plant Dynamin-Related Proteins 2 (DRP2s) and SH3-domain containing protein
2 (SH3P2), the plant homologue to Dynamins’ recruiters, like Endophilin and Amphiphysin,
in the CME by combining high-resolution imaging of endocytic events in vivo and
characterisation of the purified proteins in vitro. Although DRP2s and SH3P2 arrive
similarly late during CME and physically interact, genetic analysis of the sh3p123
triple-mutant and complementation assays with non-SH3P2-interacting DRP2 variants
suggests that SH3P2 does not directly recruit DRP2s to the site of endocytosis.
These observations imply that despite the presence of many well-conserved endocytic
components, plants have acquired a distinct mechanism for CME.
acknowledged_ssus:
- _id: EM-Fac
- _id: LifeSc
- _id: Bio
acknowledgement: "Nataliia Gnyliukh was partially funded by the European Union’s Horizon
2020 research and\r\ninnovation program (2018-2020) under the Marie Sklodowska-Curie
Grant (agreement no.\r\n665385). Taif University Researchers Supporting Project:
TURSP-HC2022/02. and Austrian\r\nScience Fund (FWF): I 6123-B.We thank Prof. Eileen
Lafer and Liping Wang for their suggestions regarding the optimisation of protein
expression and purification. We thank Prof. Sebastian Y. Bednarek for the useful
comments and constructive criticism of the project. We thank Maciek Adamowski for
providing genetic material. This research was supported by the Scientific Service
Units (SSU) of IST-Austria through resources provided by the Electron microscopy
(EMF), Lab Support Facility (LSF) (particularly Dorota Jaworska) and the Bioimaging
Facility (BIF)."
article_number: jcs.261720
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Nataliia
full_name: Gnyliukh, Nataliia
id: 390C1120-F248-11E8-B48F-1D18A9856A87
last_name: Gnyliukh
orcid: 0000-0002-2198-0509
- first_name: Alexander J
full_name: Johnson, Alexander J
id: 46A62C3A-F248-11E8-B48F-1D18A9856A87
last_name: Johnson
orcid: 0000-0002-2739-8843
- first_name: MK
full_name: Nagel, MK
last_name: Nagel
- first_name: Aline
full_name: Monzer, Aline
id: 2DB5D88C-D7B3-11E9-B8FD-7907E6697425
last_name: Monzer
- first_name: David
full_name: Babic, David
id: db566d23-f6e0-11ea-865d-e6f270e968e7
last_name: Babic
- first_name: Annamaria
full_name: Hlavata, Annamaria
id: 36062FEC-F248-11E8-B48F-1D18A9856A87
last_name: Hlavata
- first_name: SS
full_name: Alotaibi, SS
last_name: Alotaibi
- first_name: E
full_name: Isono, E
last_name: Isono
- first_name: Martin
full_name: Loose, Martin
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Gnyliukh N, Johnson AJ, Nagel M, et al. Role of dynamin-related proteins 2
and SH3P2 in clathrin-mediated endocytosis in Arabidopsis thaliana. Journal
of Cell Science. 2024;137(8). doi:10.1242/jcs.261720
apa: Gnyliukh, N., Johnson, A. J., Nagel, M., Monzer, A., Babic, D., Hlavata, A.,
… Friml, J. (2024). Role of dynamin-related proteins 2 and SH3P2 in clathrin-mediated
endocytosis in Arabidopsis thaliana. Journal of Cell Science. The Company
of Biologists. https://doi.org/10.1242/jcs.261720
chicago: Gnyliukh, Nataliia, Alexander J Johnson, MK Nagel, Aline Monzer, David
Babic, Annamaria Hlavata, SS Alotaibi, E Isono, Martin Loose, and Jiří Friml.
“Role of Dynamin-Related Proteins 2 and SH3P2 in Clathrin-Mediated Endocytosis
in Arabidopsis Thaliana.” Journal of Cell Science. The Company of Biologists,
2024. https://doi.org/10.1242/jcs.261720.
ieee: N. Gnyliukh et al., “Role of dynamin-related proteins 2 and SH3P2 in
clathrin-mediated endocytosis in Arabidopsis thaliana,” Journal of Cell Science,
vol. 137, no. 8. The Company of Biologists, 2024.
ista: Gnyliukh N, Johnson AJ, Nagel M, Monzer A, Babic D, Hlavata A, Alotaibi S,
Isono E, Loose M, Friml J. 2024. Role of dynamin-related proteins 2 and SH3P2
in clathrin-mediated endocytosis in Arabidopsis thaliana. Journal of Cell Science.
137(8), jcs. 261720.
mla: Gnyliukh, Nataliia, et al. “Role of Dynamin-Related Proteins 2 and SH3P2 in
Clathrin-Mediated Endocytosis in Arabidopsis Thaliana.” Journal of Cell Science,
vol. 137, no. 8, jcs. 261720, The Company of Biologists, 2024, doi:10.1242/jcs.261720.
short: N. Gnyliukh, A.J. Johnson, M. Nagel, A. Monzer, D. Babic, A. Hlavata, S.
Alotaibi, E. Isono, M. Loose, J. Friml, Journal of Cell Science 137 (2024).
corr_author: '1'
date_created: 2024-04-19T09:54:59Z
date_published: 2024-04-01T00:00:00Z
date_updated: 2025-09-04T13:49:45Z
day: '01'
ddc:
- '570'
department:
- _id: MaLo
- _id: JiFr
- _id: CaBe
doi: 10.1242/jcs.261720
ec_funded: 1
external_id:
isi:
- '001266917100005'
pmid:
- '38506228'
file:
- access_level: open_access
checksum: 6dc023f0cc7052ad3cf0a42589d2e30f
content_type: application/pdf
creator: dernst
date_created: 2025-01-09T08:41:16Z
date_updated: 2025-01-09T08:41:16Z
file_id: '18792'
file_name: 2024_JourCellScience_Gnyliukh.pdf
file_size: 25845948
relation: main_file
success: 1
file_date_updated: 2025-01-09T08:41:16Z
fulldoi: https://doi.org/10.1242/jcs.261720
has_accepted_license: '1'
intvolume: ' 137'
isi: 1
issue: '8'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: bd76d395-d553-11ed-ba76-f678c14f9033
grant_number: I06123
name: Peptide receptors for auxin canalization in Arabidopsis
publication: Journal of Cell Science
publication_identifier:
eissn:
- 1477-9137
issn:
- 0021-9533
publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
related_material:
record:
- id: '14591'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Role of dynamin-related proteins 2 and SH3P2 in clathrin-mediated endocytosis
in Arabidopsis thaliana
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 137
year: '2024'
...
---
_id: '15333'
abstract:
- lang: eng
text: BUBAAK-SpLit is a tool for dynamically splitting verification tasks into parts
that can then be analyzed in parallel. It is built on top of BUBAAK, a tool designed
for running combinations of verifiers in parallel. In contrast to BUBAAK, that
directly invokes verifiers on the inputs, BUBAAK-SpLit first starts by splitting
the input program into multiple modified versions called program splits. During
the splitting process, BUBAAK-SpLit utilizes a weak verifier (in our case symbolic
execution with a short timelimit) to analyze each generated program split. If
the weak verifier fails on a program split, we split this program split again
and start the verification process again on the generated program splits. We run
the splitting process until a predefined number of hard-to-verify program splits
is generated or a splitting limit is reached. During the main verification phase,
we run a combination of BUBAAK-LEE and SLOWBEAST in parallel on the remaining
unsolved parts of the verification task.
acknowledgement: This work was partially supported by the ERC-2020-AdG 10102009 grant.
alternative_title:
- LNCS
article_processing_charge: Yes (in subscription journal)
author:
- first_name: Marek
full_name: Chalupa, Marek
id: 87e34708-d6c6-11ec-9f5b-9391e7be2463
last_name: Chalupa
- first_name: Cedric
full_name: Richter, Cedric
last_name: Richter
citation:
ama: 'Chalupa M, Richter C. Bubaak-SpLit: Split what you cannot verify (Competition
contribution). In: 30th International Conference on Tools and Algorithms for
the Construction and Analysis of Systems. Vol 14572. Springer Nature; 2024:353–358.
doi:10.1007/978-3-031-57256-2_20'
apa: 'Chalupa, M., & Richter, C. (2024). Bubaak-SpLit: Split what you cannot
verify (Competition contribution). In 30th International Conference on Tools
and Algorithms for the Construction and Analysis of Systems (Vol. 14572, pp.
353–358). Luxembourg City, Luxembourg: Springer Nature. https://doi.org/10.1007/978-3-031-57256-2_20'
chicago: 'Chalupa, Marek, and Cedric Richter. “Bubaak-SpLit: Split What You Cannot
Verify (Competition Contribution).” In 30th International Conference on Tools
and Algorithms for the Construction and Analysis of Systems, 14572:353–358.
Springer Nature, 2024. https://doi.org/10.1007/978-3-031-57256-2_20.'
ieee: 'M. Chalupa and C. Richter, “Bubaak-SpLit: Split what you cannot verify (Competition
contribution),” in 30th International Conference on Tools and Algorithms for
the Construction and Analysis of Systems, Luxembourg City, Luxembourg, 2024,
vol. 14572, pp. 353–358.'
ista: 'Chalupa M, Richter C. 2024. Bubaak-SpLit: Split what you cannot verify (Competition
contribution). 30th International Conference on Tools and Algorithms for the Construction
and Analysis of Systems. TACAS: Tools and Algorithms for the Construction and
Analysis of Systems, LNCS, vol. 14572, 353–358.'
mla: 'Chalupa, Marek, and Cedric Richter. “Bubaak-SpLit: Split What You Cannot Verify
(Competition Contribution).” 30th International Conference on Tools and Algorithms
for the Construction and Analysis of Systems, vol. 14572, Springer Nature,
2024, pp. 353–358, doi:10.1007/978-3-031-57256-2_20.'
short: M. Chalupa, C. Richter, in:, 30th International Conference on Tools and Algorithms
for the Construction and Analysis of Systems, Springer Nature, 2024, pp. 353–358.
conference:
end_date: 2024-04-11
location: Luxembourg City, Luxembourg
name: 'TACAS: Tools and Algorithms for the Construction and Analysis of Systems'
start_date: 2024-04-06
corr_author: '1'
date_created: 2024-04-20T18:14:06Z
date_published: 2024-04-05T00:00:00Z
date_updated: 2025-09-04T13:48:25Z
day: '05'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1007/978-3-031-57256-2_20
ec_funded: 1
external_id:
isi:
- '001284187100020'
file:
- access_level: open_access
checksum: 208c855c60824bec936b8d01d0396474
content_type: application/pdf
creator: cchlebak
date_created: 2024-04-26T11:27:26Z
date_updated: 2024-04-26T11:27:26Z
file_id: '15347'
file_name: 2024_LNCS_Chalupa.pdf
file_size: 577128
relation: main_file
success: 1
file_date_updated: 2024-04-26T11:27:26Z
fulldoi: https://doi.org/10.1007/978-3-031-57256-2_20
has_accepted_license: '1'
intvolume: ' 14572'
isi: 1
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 353–358
project:
- _id: 62781420-2b32-11ec-9570-8d9b63373d4d
call_identifier: H2020
grant_number: '101020093'
name: Vigilant Algorithmic Monitoring of Software
publication: 30th International Conference on Tools and Algorithms for the Construction
and Analysis of Systems
publication_identifier:
eisbn:
- '9783031572562'
eissn:
- 1611-3349
isbn:
- '9783031572555'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Bubaak-SpLit: Split what you cannot verify (Competition contribution)'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 14572
year: '2024'
...
---
_id: '15334'
abstract:
- lang: eng
text: We consider the sharp interface limit of a Navier-Stokes/Allen Cahn equation
in a bounded smooth domain in two space dimensions, in the case of vanishing mobility
mε=ε√, where the small parameter ε>0 related to the thickness of the diffuse interface
is sent to zero. For well-prepared initial data and sufficiently small times,
we rigorously prove convergence to the classical two-phase Navier-Stokes system
with surface tension. The idea of the proof is to use asymptotic expansions to
construct an approximate solution and to estimate the difference of the exact
and approximate solutions with a spectral estimate for the (at the approximate
solution) linearized Allen-Cahn operator. In the calculations we use a fractional
order ansatz and new ansatz terms in higher orders leading to a suitable ε-scaled
and coupled model problem. Moreover, we apply the novel idea of introducing ε-dependent
coordinates.
acknowledgement: "Open Access funding enabled and organized by Projekt DEAL.\r\nM.
Fei was partially supported by NSF of China under Grant No. 12271004 and Anhui Provincial
Funding Project under Grant Nos. gxbjZD2022009 and 2308085J10. Moreover, M. Moser
has received funding from the European Research Council (ERC) under the European
Union’s Horizon 2020 research and innovation programme (Grant Agreement No 948819)."
article_number: '94'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Helmut
full_name: Abels, Helmut
last_name: Abels
- first_name: Mingwen
full_name: Fei, Mingwen
last_name: Fei
- first_name: Maximilian
full_name: Moser, Maximilian
id: a60047a9-da77-11eb-85b4-c4dc385ebb8c
last_name: Moser
citation:
ama: Abels H, Fei M, Moser M. Sharp interface limit for a Navier–Stokes/Allen–Cahn
system in the case of a vanishing mobility. Calculus of Variations and Partial
Differential Equations. 2024;63(4). doi:10.1007/s00526-024-02715-7
apa: Abels, H., Fei, M., & Moser, M. (2024). Sharp interface limit for a Navier–Stokes/Allen–Cahn
system in the case of a vanishing mobility. Calculus of Variations and Partial
Differential Equations. Springer Nature. https://doi.org/10.1007/s00526-024-02715-7
chicago: Abels, Helmut, Mingwen Fei, and Maximilian Moser. “Sharp Interface Limit
for a Navier–Stokes/Allen–Cahn System in the Case of a Vanishing Mobility.” Calculus
of Variations and Partial Differential Equations. Springer Nature, 2024. https://doi.org/10.1007/s00526-024-02715-7.
ieee: H. Abels, M. Fei, and M. Moser, “Sharp interface limit for a Navier–Stokes/Allen–Cahn
system in the case of a vanishing mobility,” Calculus of Variations and Partial
Differential Equations, vol. 63, no. 4. Springer Nature, 2024.
ista: Abels H, Fei M, Moser M. 2024. Sharp interface limit for a Navier–Stokes/Allen–Cahn
system in the case of a vanishing mobility. Calculus of Variations and Partial
Differential Equations. 63(4), 94.
mla: Abels, Helmut, et al. “Sharp Interface Limit for a Navier–Stokes/Allen–Cahn
System in the Case of a Vanishing Mobility.” Calculus of Variations and Partial
Differential Equations, vol. 63, no. 4, 94, Springer Nature, 2024, doi:10.1007/s00526-024-02715-7.
short: H. Abels, M. Fei, M. Moser, Calculus of Variations and Partial Differential
Equations 63 (2024).
date_created: 2024-04-21T22:00:52Z
date_published: 2024-05-01T00:00:00Z
date_updated: 2025-09-04T13:45:40Z
day: '01'
ddc:
- '510'
department:
- _id: JuFi
doi: 10.1007/s00526-024-02715-7
ec_funded: 1
external_id:
arxiv:
- '2304.12096'
isi:
- '001199418100002'
file:
- access_level: open_access
checksum: b1095fad4cae596f52cc616a973bdde2
content_type: application/pdf
creator: dernst
date_created: 2024-04-23T07:30:48Z
date_updated: 2024-04-23T07:30:48Z
file_id: '15343'
file_name: 2024_CalculusEquations_Abels.pdf
file_size: 975186
relation: main_file
success: 1
file_date_updated: 2024-04-23T07:30:48Z
fulldoi: https://doi.org/10.1007/s00526-024-02715-7
has_accepted_license: '1'
intvolume: ' 63'
isi: 1
issue: '4'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
project:
- _id: 0aa76401-070f-11eb-9043-b5bb049fa26d
call_identifier: H2020
grant_number: '948819'
name: Bridging Scales in Random Materials
publication: Calculus of Variations and Partial Differential Equations
publication_identifier:
eissn:
- 1432-0835
issn:
- 0944-2669
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sharp interface limit for a Navier–Stokes/Allen–Cahn system in the case of
a vanishing mobility
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 63
year: '2024'
...
---
_id: '15335'
abstract:
- lang: eng
text: Stable matching of neurotransmitters with their receptors is fundamental to
synapse function and reliable communication in neural circuits. Presynaptic neurotransmitters
regulate the stabilization of postsynaptic transmitter receptors. Whether postsynaptic
receptors regulate stabilization of presynaptic transmitters has received less
attention. Here, we show that blockade of endogenous postsynaptic acetylcholine
receptors (AChR) at the neuromuscular junction destabilizes the cholinergic phenotype
in motor neurons and stabilizes an earlier, developmentally transient glutamatergic
phenotype. Further, expression of exogenous postsynaptic gamma-aminobutyric acid
type A receptors (GABAA receptors) in muscle cells stabilizes an earlier, developmentally
transient GABAergic motor neuron phenotype. Both AChR and GABAA receptors are
linked to presynaptic neurons through transsynaptic bridges. Knockdown of specific
components of these transsynaptic bridges prevents stabilization of the cholinergic
or GABAergic phenotypes. Bidirectional communication can enforce a match between
transmitter and receptor and ensure the fidelity of synaptic transmission. Our
findings suggest a potential role of dysfunctional transmitter receptors in neurological
disorders that involve the loss of the presynaptic transmitter.
acknowledgement: We thank all members of the Spitzer laboratory for discussions and critical feedback; K. Marek for discussions of acknowledgment signals;
I. Gregor and R. Aricescu for discussions of receptor pharmacology and transsynaptic bridges; C. Kintner for advice on Xenopus blastomere lineage; A. Ray
and E. Park for guidance on miniature analysis; A. Glavis- Bloom, S.U. Choi, S.
Atkins, M. Gupta, and S. Malladi for technical assistance; and D. K. Berg and L.
R. Squire for comments on the manuscript. This work was supported by NSF 2051555
and the Overland Foundation. Microscopy for five- channel imaging utilized the UCSD
School of Medicine Microscopy Core, supported by NIH grant NS047101.
article_number: e2318041121
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Swetha K.
full_name: Godavarthi, Swetha K.
last_name: Godavarthi
- first_name: Masaki
full_name: Hiramoto, Masaki
last_name: Hiramoto
- first_name: Yuri
full_name: Ignatyev, Yuri
last_name: Ignatyev
- first_name: Jacqueline B.
full_name: Levin, Jacqueline B.
last_name: Levin
- first_name: Hui Quan
full_name: Li, Hui Quan
last_name: Li
- first_name: Marta
full_name: Pratelli, Marta
last_name: Pratelli
- first_name: Jennifer
full_name: Borchardt, Jennifer
last_name: Borchardt
- first_name: Cynthia
full_name: Czajkowski, Cynthia
last_name: Czajkowski
- first_name: Laura N.
full_name: Borodinsky, Laura N.
last_name: Borodinsky
- first_name: Lora Beatrice Jaeger
full_name: Sweeney, Lora Beatrice Jaeger
id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
last_name: Sweeney
orcid: 0000-0001-9242-5601
- first_name: Hollis T.
full_name: Cline, Hollis T.
last_name: Cline
- first_name: Nicholas C.
full_name: Spitzer, Nicholas C.
last_name: Spitzer
citation:
ama: Godavarthi SK, Hiramoto M, Ignatyev Y, et al. Postsynaptic receptors regulate
presynaptic transmitter stability through transsynaptic bridges. Proceedings
of the National Academy of Sciences of the United States of America. 2024;121(15).
doi:10.1073/pnas.2318041121
apa: Godavarthi, S. K., Hiramoto, M., Ignatyev, Y., Levin, J. B., Li, H. Q., Pratelli,
M., … Spitzer, N. C. (2024). Postsynaptic receptors regulate presynaptic transmitter
stability through transsynaptic bridges. Proceedings of the National Academy
of Sciences of the United States of America. National Academy of Sciences.
https://doi.org/10.1073/pnas.2318041121
chicago: Godavarthi, Swetha K., Masaki Hiramoto, Yuri Ignatyev, Jacqueline B. Levin,
Hui Quan Li, Marta Pratelli, Jennifer Borchardt, et al. “Postsynaptic Receptors
Regulate Presynaptic Transmitter Stability through Transsynaptic Bridges.” Proceedings
of the National Academy of Sciences of the United States of America. National
Academy of Sciences, 2024. https://doi.org/10.1073/pnas.2318041121.
ieee: S. K. Godavarthi et al., “Postsynaptic receptors regulate presynaptic
transmitter stability through transsynaptic bridges,” Proceedings of the National
Academy of Sciences of the United States of America, vol. 121, no. 15. National
Academy of Sciences, 2024.
ista: Godavarthi SK, Hiramoto M, Ignatyev Y, Levin JB, Li HQ, Pratelli M, Borchardt
J, Czajkowski C, Borodinsky LN, Sweeney LB, Cline HT, Spitzer NC. 2024. Postsynaptic
receptors regulate presynaptic transmitter stability through transsynaptic bridges.
Proceedings of the National Academy of Sciences of the United States of America.
121(15), e2318041121.
mla: Godavarthi, Swetha K., et al. “Postsynaptic Receptors Regulate Presynaptic
Transmitter Stability through Transsynaptic Bridges.” Proceedings of the National
Academy of Sciences of the United States of America, vol. 121, no. 15, e2318041121,
National Academy of Sciences, 2024, doi:10.1073/pnas.2318041121.
short: S.K. Godavarthi, M. Hiramoto, Y. Ignatyev, J.B. Levin, H.Q. Li, M. Pratelli,
J. Borchardt, C. Czajkowski, L.N. Borodinsky, L.B. Sweeney, H.T. Cline, N.C. Spitzer,
Proceedings of the National Academy of Sciences of the United States of America
121 (2024).
date_created: 2024-04-21T22:00:53Z
date_published: 2024-04-09T00:00:00Z
date_updated: 2025-09-04T13:42:01Z
day: '09'
ddc:
- '570'
department:
- _id: LoSw
doi: 10.1073/pnas.2318041121
external_id:
isi:
- '001243892800004'
pmid:
- '38568976'
file:
- access_level: open_access
checksum: f3b4ffad4ef3d1c443414edf0cd2392c
content_type: application/pdf
creator: dernst
date_created: 2024-04-23T06:53:14Z
date_updated: 2024-04-23T06:53:14Z
file_id: '15340'
file_name: 2024_PNAS_Godavarthi.pdf
file_size: 16187094
relation: main_file
success: 1
file_date_updated: 2024-04-23T06:53:14Z
fulldoi: https://doi.org/10.1073/pnas.2318041121
has_accepted_license: '1'
intvolume: ' 121'
isi: 1
issue: '15'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
publication: Proceedings of the National Academy of Sciences of the United States
of America
publication_identifier:
eissn:
- 1091-6490
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Postsynaptic receptors regulate presynaptic transmitter stability through transsynaptic
bridges
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 121
year: '2024'
...
---
_id: '15339'
abstract:
- lang: eng
text: We define even very stable Higgs bundles and study the Hitchin map restricted
to their upward flows. In the GLn case, we classify the type (1,…,1) examples,
and find that they are governed by a root system formed by the roots of even height.
We discuss how the spectrum of equivariant cohomology of real and quaternionic
Grassmannians, 4n-spheres and the real Cayley plane appear to describe the Hitchin
map on even cominuscule upward flows. The even upward flows in question are the
same as upward flows in Higgs bundle moduli spaces for quasi-split inner real
forms. The latter spaces have been pioneered by Oscar García-Prada and his collaborators.
acknowledgement: Most of the research for this paper was done when the first author
visited the second author's group at IST Austria as a summer intern in 2022. The
second author was supported by an FWF grant "Geometry of the top of the nilpotent
cone" number P35847.
article_number: '2441009'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Miguel
full_name: González, Miguel
last_name: González
- first_name: Tamás
full_name: Hausel, Tamás
id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
last_name: Hausel
orcid: 0000-0002-9582-2634
citation:
ama: González M, Hausel T. Hitchin map on even very stable upward flows. International
Journal of Mathematics. 2024;35(09). doi:10.1142/S0129167X2441009X
apa: González, M., & Hausel, T. (2024). Hitchin map on even very stable upward
flows. International Journal of Mathematics. World Scientific Publishing.
https://doi.org/10.1142/S0129167X2441009X
chicago: González, Miguel, and Tamás Hausel. “Hitchin Map on Even Very Stable Upward
Flows.” International Journal of Mathematics. World Scientific Publishing,
2024. https://doi.org/10.1142/S0129167X2441009X.
ieee: M. González and T. Hausel, “Hitchin map on even very stable upward flows,”
International Journal of Mathematics, vol. 35, no. 09. World Scientific
Publishing, 2024.
ista: González M, Hausel T. 2024. Hitchin map on even very stable upward flows.
International Journal of Mathematics. 35(09), 2441009.
mla: González, Miguel, and Tamás Hausel. “Hitchin Map on Even Very Stable Upward
Flows.” International Journal of Mathematics, vol. 35, no. 09, 2441009,
World Scientific Publishing, 2024, doi:10.1142/S0129167X2441009X.
short: M. González, T. Hausel, International Journal of Mathematics 35 (2024).
date_created: 2024-04-21T22:00:54Z
date_published: 2024-04-04T00:00:00Z
date_updated: 2025-09-04T13:40:37Z
day: '04'
department:
- _id: TaHa
doi: 10.1142/S0129167X2441009X
external_id:
arxiv:
- '2303.01404'
isi:
- '001251179200003'
fulldoi: https://doi.org/10.1142/S0129167X2441009X
intvolume: ' 35'
isi: 1
issue: '09'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2303.01404
month: '04'
oa: 1
oa_version: Preprint
project:
- _id: 34b2c9cb-11ca-11ed-8bc3-a50ba74ca4a3
grant_number: P35847
name: Geometry of the tip of the global nilpotent cone
publication: International Journal of Mathematics
publication_identifier:
eissn:
- 1793-6519
issn:
- 0129-167X
publication_status: published
publisher: World Scientific Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Hitchin map on even very stable upward flows
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 35
year: '2024'
...
---
OA_type: closed access
_id: '15348'
abstract:
- lang: eng
text: We report on synthesis of highly crystalline polythiophene and its application
in supercapacitor electrodes. The material exhibits a remarkably stable electrochemical
behavior and an excellent device performance. The device delivers an electrode
specific capacitance (Csp) of 129.13F g−1, Cell Csp of 32.28F g−1 at 0.5 A/g;
energy, and power densities of ∼ 3 Wh kg−1 and 250 W kg -1, respectively at 0.5
A/g. Also, it exhibits an excellent retention of Cell Csp and coulombic efficiency
up to ∼ 95 % over 10,000 continuous galvanostatic charge discharge (GCD) cycles
indicating a remarkable performance by a standalone, pristine and undoped polythiophene.
Electrochemical impedance spectroscopy (EIS) studies further suggest material’s
stable capacitive behavior. The material’s enhanced electrochemical properties,
stable behavior and outstanding performance in device application are attributed
to the crystalline phases present in the polymer matrix achievable via a slow
rate of synthesis; overall, an edge over other conventional synthesis methods.
acknowledgement: This research was supported by the Korea Evaluation Institute of
Industrial Technology (No. 200116167, Development of Battery Safety Diagnosis System
(BDS) SoC that predicts the internal state, explosion risk, remaining useful life,
and replacement timing of electric vehicle batteries).
article_number: '136483'
article_processing_charge: No
article_type: original
author:
- first_name: Neelima
full_name: Mahato, Neelima
last_name: Mahato
- first_name: Saurabh
full_name: Singh, Saurabh
id: 12d625da-9cb3-11ed-9667-af09d37d3f0a
last_name: Singh
orcid: 0000-0003-2209-5269
- first_name: T. V.M.
full_name: Sreekanth, T. V.M.
last_name: Sreekanth
- first_name: Kisoo
full_name: Yoo, Kisoo
last_name: Yoo
- first_name: Jonghoon
full_name: Kim, Jonghoon
last_name: Kim
citation:
ama: 'Mahato N, Singh S, Sreekanth TVM, Yoo K, Kim J. In-situ engineered highly
crystalline polythiophene empowered electrochemical capacitor-I: Synthesis, characterization,
and electrochemical charge storage. Materials Letters. 2024;365. doi:10.1016/j.matlet.2024.136483'
apa: 'Mahato, N., Singh, S., Sreekanth, T. V. M., Yoo, K., & Kim, J. (2024).
In-situ engineered highly crystalline polythiophene empowered electrochemical
capacitor-I: Synthesis, characterization, and electrochemical charge storage.
Materials Letters. Elsevier. https://doi.org/10.1016/j.matlet.2024.136483'
chicago: 'Mahato, Neelima, Saurabh Singh, T. V.M. Sreekanth, Kisoo Yoo, and Jonghoon
Kim. “In-Situ Engineered Highly Crystalline Polythiophene Empowered Electrochemical
Capacitor-I: Synthesis, Characterization, and Electrochemical Charge Storage.”
Materials Letters. Elsevier, 2024. https://doi.org/10.1016/j.matlet.2024.136483.'
ieee: 'N. Mahato, S. Singh, T. V. M. Sreekanth, K. Yoo, and J. Kim, “In-situ engineered
highly crystalline polythiophene empowered electrochemical capacitor-I: Synthesis,
characterization, and electrochemical charge storage,” Materials Letters,
vol. 365. Elsevier, 2024.'
ista: 'Mahato N, Singh S, Sreekanth TVM, Yoo K, Kim J. 2024. In-situ engineered
highly crystalline polythiophene empowered electrochemical capacitor-I: Synthesis,
characterization, and electrochemical charge storage. Materials Letters. 365,
136483.'
mla: 'Mahato, Neelima, et al. “In-Situ Engineered Highly Crystalline Polythiophene
Empowered Electrochemical Capacitor-I: Synthesis, Characterization, and Electrochemical
Charge Storage.” Materials Letters, vol. 365, 136483, Elsevier, 2024, doi:10.1016/j.matlet.2024.136483.'
short: N. Mahato, S. Singh, T.V.M. Sreekanth, K. Yoo, J. Kim, Materials Letters
365 (2024).
corr_author: '1'
date_created: 2024-04-28T22:00:56Z
date_published: 2024-06-15T00:00:00Z
date_updated: 2025-09-04T13:49:05Z
day: '15'
department:
- _id: MaIb
doi: 10.1016/j.matlet.2024.136483
external_id:
isi:
- '001300025600001'
fulldoi: https://doi.org/10.1016/j.matlet.2024.136483
intvolume: ' 365'
isi: 1
language:
- iso: eng
month: '06'
oa_version: None
publication: Materials Letters
publication_identifier:
eissn:
- 1873-4979
issn:
- 0167-577X
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'In-situ engineered highly crystalline polythiophene empowered electrochemical
capacitor-I: Synthesis, characterization, and electrochemical charge storage'
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 365
year: '2024'
...
---
OA_type: free access
_id: '15356'
abstract:
- lang: eng
text: Identifying efficient active sites for the direct synthesis of hydrogen peroxide
over Pd-based catalysts has been a subject of considerable debate. In this study,
we employ particle swarm optimization method and density functional theory to
explore the H2O2 synthesis mechanism on Pd, PdO, and the partially oxidized surface
(Pd9OX). A comprehensive mechanism for Pd9OX is elucidated, and subsequent coverage-dependent
kinetic analysis allows for a quantitative assessment of catalytic performance
at the interphase. Our findings conclusively establish that the interphase between
Pd and PdO represents the optimal active site. Phase diagram analysis further
aids in determining stable structures under reaction conditions. At 298.15 K and
under oxygen balance, the Pd9O6 surface remains stable throughout the reaction,
demonstrating high activity and selectivity. This work underscores the significance
of the interphase in comprehending catalytic performance and unveils promising
avenues for optimizing catalyst performance by controlling reaction conditions
and surface composition.
acknowledgement: The authors acknowledge the financial support from the National Key
Research and Development Project of China (2021YFA1500900, 2022YFE0113800), the
National Natural Science Foundation of China (22141001, U21A20298), Zhejiang Innovation
Team (2017R5203).
article_number: '120199'
article_processing_charge: No
article_type: original
author:
- first_name: Jinyan
full_name: Zhao, Jinyan
last_name: Zhao
- first_name: Zihao
full_name: Yao, Zihao
last_name: Yao
- first_name: Rhys
full_name: Bunting, Rhys
id: 91deeae8-1207-11ec-b130-c194ad5b50c6
last_name: Bunting
orcid: 0000-0001-6928-074X
- first_name: Yaqiu
full_name: Wang, Yaqiu
last_name: Wang
- first_name: Jianguo
full_name: Wang, Jianguo
last_name: Wang
citation:
ama: Zhao J, Yao Z, Bunting R, Wang Y, Wang J. Identifying Pd9OX as the optimum
catalyst for the direct synthesis of H2O2 through microkinetic modeling with coverage
effects. Chemical Engineering Science. 2024;295. doi:10.1016/j.ces.2024.120199
apa: Zhao, J., Yao, Z., Bunting, R., Wang, Y., & Wang, J. (2024). Identifying
Pd9OX as the optimum catalyst for the direct synthesis of H2O2 through microkinetic
modeling with coverage effects. Chemical Engineering Science. Elsevier.
https://doi.org/10.1016/j.ces.2024.120199
chicago: Zhao, Jinyan, Zihao Yao, Rhys Bunting, Yaqiu Wang, and Jianguo Wang. “Identifying
Pd9OX as the Optimum Catalyst for the Direct Synthesis of H2O2 through Microkinetic
Modeling with Coverage Effects.” Chemical Engineering Science. Elsevier,
2024. https://doi.org/10.1016/j.ces.2024.120199.
ieee: J. Zhao, Z. Yao, R. Bunting, Y. Wang, and J. Wang, “Identifying Pd9OX as the
optimum catalyst for the direct synthesis of H2O2 through microkinetic modeling
with coverage effects,” Chemical Engineering Science, vol. 295. Elsevier,
2024.
ista: Zhao J, Yao Z, Bunting R, Wang Y, Wang J. 2024. Identifying Pd9OX as the optimum
catalyst for the direct synthesis of H2O2 through microkinetic modeling with coverage
effects. Chemical Engineering Science. 295, 120199.
mla: Zhao, Jinyan, et al. “Identifying Pd9OX as the Optimum Catalyst for the Direct
Synthesis of H2O2 through Microkinetic Modeling with Coverage Effects.” Chemical
Engineering Science, vol. 295, 120199, Elsevier, 2024, doi:10.1016/j.ces.2024.120199.
short: J. Zhao, Z. Yao, R. Bunting, Y. Wang, J. Wang, Chemical Engineering Science
295 (2024).
date_created: 2024-05-05T22:01:02Z
date_published: 2024-08-05T00:00:00Z
date_updated: 2025-09-04T13:54:17Z
day: '05'
department:
- _id: MaIb
doi: 10.1016/j.ces.2024.120199
external_id:
isi:
- '001236643300001'
fulldoi: https://doi.org/10.1016/j.ces.2024.120199
intvolume: ' 295'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.ces.2024.120199
month: '08'
oa: 1
oa_version: None
publication: Chemical Engineering Science
publication_identifier:
issn:
- 0009-2509
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Identifying Pd9OX as the optimum catalyst for the direct synthesis of H2O2
through microkinetic modeling with coverage effects
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 295
year: '2024'
...