--- OA_place: publisher OA_type: hybrid _id: '18490' abstract: - lang: eng text: 'For large classes of even-dimensional Riemannian manifolds (Formula presented.), we construct and analyze conformally invariant random fields. These centered Gaussian fields (Formula presented.), called co-polyharmonic Gaussian fields, are characterized by their covariance kernels k which exhibit a precise logarithmic divergence: (Formula presented.). They share a fundamental quasi-invariance property under conformal transformations. In terms of the co-polyharmonic Gaussian field (Formula presented.), we define the Liouville Quantum Gravity measure, a random measure on (Formula presented.), heuristically given as (Formula presented.) and rigorously obtained as almost sure weak limit of the right-hand side with (Formula presented.) replaced by suitable regular approximations (Formula presented.). In terms on the Liouville Quantum Gravity measure, we define the Liouville Brownian motion on (Formula presented.) and the random GJMS operators. Finally, we present an approach to a conformal field theory in arbitrary even dimension with an ansatz based on Branson''s (Formula presented.) -curvature: we give a rigorous meaning to the Polyakov–Liouville measure (Formula presented.) and we derive the corresponding conformal anomaly. The set of admissible manifolds is conformally invariant. It includes all compact 2-dimensional Riemannian manifolds, all compact non-negatively curved Einstein manifolds of even dimension, and large classes of compact hyperbolic manifolds of even dimension. However, not every compact even-dimensional Riemannian manifold is admissible. Our results concerning the logarithmic divergence of the kernel (Formula presented.) rely on new sharp estimates for heat kernels and higher order Green kernels on arbitrary closed manifolds. ' acknowledgement: The authors are grateful to Masha Gordina for helpful references, and to Nathanaël Berestycki, Baptiste Cerclé, and Ewain Gwynne for valuable comments on the first circulated version of this paper. They also would like to thank Sebastian Andres, Peter Friz, and Yizheng Yuan for pointing out an erroneous formulation in the previous version of Theorem 5.7. Moreover, KTS would liketo express his thanks to Sebastian Andres, Matthias Erbar, Martin Huesmann, and Jan Mass for stimulating discussions on previous attempts to this project. LDS gratefully acknowledges financial support from the European Research Council (grant agreement No 716117, awarded to J. Maas), from the Austrian Science Fund (FWF) project 10.55776/ESP208, and from the Austrian Science Fund (FWF) project 10.55776/F65.RH, EK, and KTS gratefully acknowledge funding by the Deutsche Forschungsgemeinschaft through the project “Random Riemannian Geometry” within the SPP 2265 “Random Geomet-ric Systems,” through the Hausdorff Center for Mathematics (project ID 390685813), and through project B03 within the CRC 1060 (project ID 211504053). RH and KTS also gratefully acknowledge financial support from the European Research Council through the ERC AdG “RicciBounds”(grant agreement 694405).Data sharing not applicable to this article as no datasets were generated or analyzed during the current study. Open access funding enabled and organized by Projekt DEAL. article_number: e70003 article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Lorenzo full_name: Dello Schiavo, Lorenzo id: ECEBF480-9E4F-11EA-B557-B0823DDC885E last_name: Dello Schiavo orcid: 0000-0002-9881-6870 - first_name: Ronan full_name: Herry, Ronan last_name: Herry - first_name: Eva full_name: Kopfer, Eva last_name: Kopfer - first_name: Karl Theodor full_name: Sturm, Karl Theodor last_name: Sturm citation: ama: Dello Schiavo L, Herry R, Kopfer E, Sturm KT. Conformally invariant random fields, Liouville quantum gravity measures, and random Paneitz operators on Riemannian manifolds of even dimension. Journal of the London Mathematical Society. 2024;110(5). doi:10.1112/jlms.70003 apa: Dello Schiavo, L., Herry, R., Kopfer, E., & Sturm, K. T. (2024). Conformally invariant random fields, Liouville quantum gravity measures, and random Paneitz operators on Riemannian manifolds of even dimension. Journal of the London Mathematical Society. London Mathematical Society. https://doi.org/10.1112/jlms.70003 chicago: Dello Schiavo, Lorenzo, Ronan Herry, Eva Kopfer, and Karl Theodor Sturm. “Conformally Invariant Random Fields, Liouville Quantum Gravity Measures, and Random Paneitz Operators on Riemannian Manifolds of Even Dimension.” Journal of the London Mathematical Society. London Mathematical Society, 2024. https://doi.org/10.1112/jlms.70003. ieee: L. Dello Schiavo, R. Herry, E. Kopfer, and K. T. Sturm, “Conformally invariant random fields, Liouville quantum gravity measures, and random Paneitz operators on Riemannian manifolds of even dimension,” Journal of the London Mathematical Society, vol. 110, no. 5. London Mathematical Society, 2024. ista: Dello Schiavo L, Herry R, Kopfer E, Sturm KT. 2024. Conformally invariant random fields, Liouville quantum gravity measures, and random Paneitz operators on Riemannian manifolds of even dimension. Journal of the London Mathematical Society. 110(5), e70003. mla: Dello Schiavo, Lorenzo, et al. “Conformally Invariant Random Fields, Liouville Quantum Gravity Measures, and Random Paneitz Operators on Riemannian Manifolds of Even Dimension.” Journal of the London Mathematical Society, vol. 110, no. 5, e70003, London Mathematical Society, 2024, doi:10.1112/jlms.70003. short: L. Dello Schiavo, R. Herry, E. Kopfer, K.T. Sturm, Journal of the London Mathematical Society 110 (2024). date_created: 2024-11-03T23:01:44Z date_published: 2024-11-01T00:00:00Z date_updated: 2025-09-08T14:29:45Z day: '01' ddc: - '510' department: - _id: JaMa doi: 10.1112/jlms.70003 ec_funded: 1 external_id: isi: - '001351918100029' file: - access_level: open_access checksum: 143816823b5f43bd3748da8e3e91cef5 content_type: application/pdf creator: dernst date_created: 2024-11-04T08:54:26Z date_updated: 2024-11-04T08:54:26Z file_id: '18497' file_name: 2024_JourLondonMathSoc_Schiavo.pdf file_size: 911476 relation: main_file success: 1 file_date_updated: 2024-11-04T08:54:26Z has_accepted_license: '1' intvolume: ' 110' isi: 1 issue: '5' language: - iso: eng month: '11' oa: 1 oa_version: Published Version project: - _id: 256E75B8-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '716117' name: Optimal Transport and Stochastic Dynamics - _id: 34dbf174-11ca-11ed-8bc3-afe9d43d4b9c grant_number: E208 name: Configuration Spaces over Non-Smooth Spaces - _id: fc31cba2-9c52-11eb-aca3-ff467d239cd2 grant_number: F6504 name: Taming Complexity in Partial Differential Systems publication: Journal of the London Mathematical Society publication_identifier: eissn: - 1469-7750 issn: - 0024-6107 publication_status: published publisher: London Mathematical Society quality_controlled: '1' scopus_import: '1' status: public title: Conformally invariant random fields, Liouville quantum gravity measures, and random Paneitz operators on Riemannian manifolds of even dimension tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 110 year: '2024' ... --- APC_amount: 4569,23 EUR DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '18491' abstract: - lang: eng text: Predicting the outcomes of adaptation is a major goal of evolutionary biology. When temporal changes in the environment mirror spatial gradients, it opens up the potential for predicting the course of adaptive evolution over time based on patterns of spatial genetic and phenotypic variation. We assessed this approach in a 30-year transplant experiment in the intertidal snail Littorina saxatilis. In 1992, snails were transplanted from a predation-dominated environment to one dominated by wave action. On the basis of spatial patterns, we predicted transitions in shell size and morphology, allele frequencies at positions throughout the genome, and chromosomal rearrangement frequencies. Observed changes closely agreed with predictions and transformation was both dramatic and rapid. Hence, adaptation can be predicted from knowledge of the phenotypic and genetic variation among populations. acknowledgement: 'This work was received funding from the following: Norwegian Research Council RCN project 315287 (A.M.W.), Swedish Research Council 2021-04191 (K.J.), European Research Council grant 101055327 HaplotypeStructure (N.B.), Austrian Science Fund FWF; P 32166-B32 Snapdragon Speciation (N.B.), European Research Council (R.B.), and Portuguese Foundation for Science and Technology FCT: 2020.00275.CEECIND and PTDC/BIA-EVL/1614/2021 (R.F.).' article_number: eadp2102 article_processing_charge: Yes article_type: original author: - first_name: Diego Fernando full_name: Garcia Castillo, Diego Fernando id: ae681a14-dc74-11ea-a0a7-c6ef18161701 last_name: Garcia Castillo - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 - first_name: Rui full_name: Faria, Rui last_name: Faria - first_name: Jenny full_name: Larsson, Jenny last_name: Larsson - first_name: Sean full_name: Stankowski, Sean id: 43161670-5719-11EA-8025-FABC3DDC885E last_name: Stankowski - first_name: Roger full_name: Butlin, Roger last_name: Butlin - first_name: Kerstin full_name: Johannesson, Kerstin last_name: Johannesson - first_name: Anja M full_name: Westram, Anja M id: 3C147470-F248-11E8-B48F-1D18A9856A87 last_name: Westram orcid: 0000-0003-1050-4969 citation: ama: 'Garcia Castillo DF, Barton NH, Faria R, et al. Predicting rapid adaptation in time from adaptation in space: A 30-year field experiment in marine snails. Science Advances. 2024;10(41). doi:10.1126/sciadv.adp2102' apa: 'Garcia Castillo, D. F., Barton, N. H., Faria, R., Larsson, J., Stankowski, S., Butlin, R., … Westram, A. M. (2024). Predicting rapid adaptation in time from adaptation in space: A 30-year field experiment in marine snails. Science Advances. AAAS. https://doi.org/10.1126/sciadv.adp2102' chicago: 'Garcia Castillo, Diego Fernando, Nicholas H Barton, Rui Faria, Jenny Larsson, Sean Stankowski, Roger Butlin, Kerstin Johannesson, and Anja M Westram. “Predicting Rapid Adaptation in Time from Adaptation in Space: A 30-Year Field Experiment in Marine Snails.” Science Advances. AAAS, 2024. https://doi.org/10.1126/sciadv.adp2102.' ieee: 'D. F. Garcia Castillo et al., “Predicting rapid adaptation in time from adaptation in space: A 30-year field experiment in marine snails,” Science Advances, vol. 10, no. 41. AAAS, 2024.' ista: 'Garcia Castillo DF, Barton NH, Faria R, Larsson J, Stankowski S, Butlin R, Johannesson K, Westram AM. 2024. Predicting rapid adaptation in time from adaptation in space: A 30-year field experiment in marine snails. Science Advances. 10(41), eadp2102.' mla: 'Garcia Castillo, Diego Fernando, et al. “Predicting Rapid Adaptation in Time from Adaptation in Space: A 30-Year Field Experiment in Marine Snails.” Science Advances, vol. 10, no. 41, eadp2102, AAAS, 2024, doi:10.1126/sciadv.adp2102.' short: D.F. Garcia Castillo, N.H. Barton, R. Faria, J. Larsson, S. Stankowski, R. Butlin, K. Johannesson, A.M. Westram, Science Advances 10 (2024). corr_author: '1' date_created: 2024-11-03T23:01:44Z date_published: 2024-10-11T00:00:00Z date_updated: 2026-04-07T11:42:09Z day: '11' ddc: - '570' department: - _id: NiBa doi: 10.1126/sciadv.adp2102 external_id: isi: - '001354405400018' file: - access_level: open_access checksum: 96aa0d3640fa9401975138e59054f84e content_type: application/pdf creator: dernst date_created: 2024-11-04T09:35:49Z date_updated: 2024-11-04T09:35:49Z file_id: '18499' file_name: 2024_ScienceAdv_Castillo.pdf file_size: 1154107 relation: main_file success: 1 file_date_updated: 2024-11-04T09:35:49Z has_accepted_license: '1' intvolume: ' 10' isi: 1 issue: '41' language: - iso: eng month: '10' oa: 1 oa_version: Published Version project: - _id: bd6958e0-d553-11ed-ba76-86eba6a76c00 grant_number: '101055327' name: Understanding the evolution of continuous genomes - _id: 05959E1C-7A3F-11EA-A408-12923DDC885E grant_number: P32166 name: Snapdragon Speciation - _id: 3AC91DDA-15DF-11EA-824D-93A3E7B544D1 call_identifier: FWF name: FWF Open Access Fund publication: Science Advances publication_identifier: eissn: - 2375-2548 publication_status: published publisher: AAAS quality_controlled: '1' related_material: link: - relation: software url: https://github.com/fernandoGarcia21/littorina_saxatilis_skerry record: - id: '18498' relation: research_data status: public - id: '20991' relation: dissertation_contains status: public scopus_import: '1' status: public title: 'Predicting rapid adaptation in time from adaptation in space: A 30-year field experiment in marine snails' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 10 year: '2024' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '18494' abstract: - lang: eng text: We expect luminous (M 1450 ≲ −26.5) high-redshift quasars to trace the highest-density peaks in the early Universe. Here, we present observations of four z ≳ 6 quasar fields using JWST/NIRCam in the imaging and wide-field slitless spectroscopy mode and report a wide range in the number of detected [O iii]-emitting galaxies in the quasars’ environments, ranging between a density enhancement of δ ≈ 65 within a 2 cMpc radius—one of the largest protoclusters during the Epoch of Reionization discovered to date—to a density contrast consistent with zero, indicating the presence of a UV-luminous quasar in a region comparable to the average density of the Universe. By measuring the two-point cross-correlation function of quasars and their surrounding galaxies, as well as the galaxy autocorrelation function, we infer a correlation length of quasars at 〈z〉 = 6.25 of r 0 QQ = 22.0 − 2.9 + 3.0 cMpc h − 1 , while we obtain a correlation length of the [O iii]-emitting galaxies of r 0 GG = 4.1 ± 0.3 cMpc h − 1 . By comparing the correlation functions to dark-matter-only simulations we estimate the minimum mass of the quasars’ host dark matter halos to be log 10 ( M halo , min / M ⊙ ) = 12.43 − 0.15 + 0.13 (and log 10 ( M halo , min [ OIII ] / M ⊙ ) = 10.56 − 0.03 + 0.05 for the [O iii] emitters), indicating that (a) luminous quasars do not necessarily reside within the most overdense regions in the early Universe, and that (b) the UV-luminous duty cycle of quasar activity at these redshifts is f duty ≪ 1. Such short quasar activity timescales challenge our understanding of early supermassive black hole growth and provide evidence for highly dust-obscured growth phases or episodic, radiatively inefficient accretion rates. acknowledgement: "The authors would like to thank the anonymous referee for the thoughtful comments, which significantly improved our manuscript, and Jan-Torge Schindler, Jiamu Huang, and Feige Wang for helpful discussions.\r\n\r\nJ.F.H. and E.P. acknowledge support from the European Research Council (ERC) under the European Unions Horizon 2020 research and innovation program (grant agreement No. 885301). J.M. acknowledges support from the European Union (ERC, AGENTS, 101076224).\r\n\r\nThis work is based on observations made with the NASA/ESA/CSA James Webb Space Telescope. The JWST data presented in this article were obtained from the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. The specific observations analyzed are associated with program #1243 and can be accessed via doi:10.17909/m5mp-5v90.\r\n\r\nThis work used the DiRAC Memory Intensive service (Cosma8) at the University of Durham, which is part of the STFC DiRAC HPC Facility (www.dirac.ac.uk). Access to DiRAC resources was granted through a Directors Discretionary Time allocation in 2023/24, under the auspices of the UKRI-funded DiRAC Federation Project. The equipment was funded by BEIS capital funding via STFC capital grants ST/K00042X/1, ST/P002293/1, ST/R002371/1, and ST/S002502/1, Durham University and STFC operations grant ST/R000832/1. DiRAC is part of the National e-Infrastructure.\r\n\r\nWe thank the Instituto de Astrofisica de Andalucia (IAA-CSIC), Centro de Supercomputacion de Galicia (CESGA), and Spanish Academic and Research Network (RedIRIS) in Spain for hosting Uchuu DR1, DR2, and DR3 in the Skies & Universes site for cosmological simulations. The Uchuu simulations were carried out on the Aterui II supercomputer at the Center for Computational Astrophysics, CfCA, of the National Astronomical Observatory of Japan, and the K computer at the RIKEN Advanced Institute for Computational Science. The Uchuu Data Releases efforts have made use of the skunIAA_RedIRIS and skun6IAA computer facilities managed by the IAA-CSIC in Spain (MICINN EU-Feder grant EQC2018-004366-P)." article_number: '275' article_processing_charge: Yes article_type: original author: - first_name: Anna Christina full_name: Eilers, Anna Christina last_name: Eilers - first_name: Ruari full_name: Mackenzie, Ruari last_name: Mackenzie - first_name: Elia full_name: Pizzati, Elia last_name: Pizzati - first_name: Jorryt J full_name: Matthee, Jorryt J id: 7439a258-f3c0-11ec-9501-9df22fe06720 last_name: Matthee orcid: 0000-0003-2871-127X - first_name: Joseph F. full_name: Hennawi, Joseph F. last_name: Hennawi - first_name: Haowen full_name: Zhang, Haowen last_name: Zhang - first_name: Rongmon full_name: Bordoloi, Rongmon last_name: Bordoloi - first_name: Daichi full_name: Kashino, Daichi last_name: Kashino - first_name: Simon J. full_name: Lilly, Simon J. last_name: Lilly - first_name: Rohan P. full_name: Naidu, Rohan P. last_name: Naidu - first_name: Robert A. full_name: Simcoe, Robert A. last_name: Simcoe - first_name: Minghao full_name: Yue, Minghao last_name: Yue - first_name: Carlos S. full_name: Frenk, Carlos S. last_name: Frenk - first_name: John C. full_name: Helly, John C. last_name: Helly - first_name: Matthieu full_name: Schaller, Matthieu last_name: Schaller - first_name: Joop full_name: Schaye, Joop last_name: Schaye citation: ama: Eilers AC, Mackenzie R, Pizzati E, et al. EIGER. VI. The correlation function, host halo mass, and duty cycle of luminous quasars at z ≳ 6. Astrophysical Journal. 2024;974(2). doi:10.3847/1538-4357/ad778b apa: Eilers, A. C., Mackenzie, R., Pizzati, E., Matthee, J. J., Hennawi, J. F., Zhang, H., … Schaye, J. (2024). EIGER. VI. The correlation function, host halo mass, and duty cycle of luminous quasars at z ≳ 6. Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ad778b chicago: Eilers, Anna Christina, Ruari Mackenzie, Elia Pizzati, Jorryt J Matthee, Joseph F. Hennawi, Haowen Zhang, Rongmon Bordoloi, et al. “EIGER. VI. The Correlation Function, Host Halo Mass, and Duty Cycle of Luminous Quasars at z ≳ 6.” Astrophysical Journal. IOP Publishing, 2024. https://doi.org/10.3847/1538-4357/ad778b. ieee: A. C. Eilers et al., “EIGER. VI. The correlation function, host halo mass, and duty cycle of luminous quasars at z ≳ 6,” Astrophysical Journal, vol. 974, no. 2. IOP Publishing, 2024. ista: Eilers AC, Mackenzie R, Pizzati E, Matthee JJ, Hennawi JF, Zhang H, Bordoloi R, Kashino D, Lilly SJ, Naidu RP, Simcoe RA, Yue M, Frenk CS, Helly JC, Schaller M, Schaye J. 2024. EIGER. VI. The correlation function, host halo mass, and duty cycle of luminous quasars at z ≳ 6. Astrophysical Journal. 974(2), 275. mla: Eilers, Anna Christina, et al. “EIGER. VI. The Correlation Function, Host Halo Mass, and Duty Cycle of Luminous Quasars at z ≳ 6.” Astrophysical Journal, vol. 974, no. 2, 275, IOP Publishing, 2024, doi:10.3847/1538-4357/ad778b. short: A.C. Eilers, R. Mackenzie, E. Pizzati, J.J. Matthee, J.F. Hennawi, H. Zhang, R. Bordoloi, D. Kashino, S.J. Lilly, R.P. Naidu, R.A. Simcoe, M. Yue, C.S. Frenk, J.C. Helly, M. Schaller, J. Schaye, Astrophysical Journal 974 (2024). date_created: 2024-11-03T23:01:45Z date_published: 2024-10-01T00:00:00Z date_updated: 2025-09-08T14:29:05Z day: '01' ddc: - '520' department: - _id: JoMa doi: 10.3847/1538-4357/ad778b external_id: isi: - '001338877100001' file: - access_level: open_access checksum: 1fcac3d11d01d91cf2bb4963b6e10b22 content_type: application/pdf creator: dernst date_created: 2024-11-04T08:42:23Z date_updated: 2024-11-04T08:42:23Z file_id: '18496' file_name: 2024_AstrophysicalJour_Eilers.pdf file_size: 1042470 relation: main_file success: 1 file_date_updated: 2024-11-04T08:42:23Z has_accepted_license: '1' intvolume: ' 974' isi: 1 issue: '2' language: - iso: eng month: '10' oa: 1 oa_version: Published Version project: - _id: bd9b2118-d553-11ed-ba76-db24564edfea grant_number: '101076224' name: Young galaxies as tracers and agents of cosmic reionization publication: Astrophysical Journal publication_identifier: eissn: - 1538-4357 issn: - 0004-637X publication_status: published publisher: IOP Publishing quality_controlled: '1' scopus_import: '1' status: public title: EIGER. VI. The correlation function, host halo mass, and duty cycle of luminous quasars at z ≳ 6 tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 974 year: '2024' ... --- OA_place: repository _id: '18498' abstract: - lang: eng text: 'Scripts and data used in the research study Predicting rapid adaptation in time from adaptation in space: a 30-year field experiment in marine snails. https://doi.org/10.1101/2023.09.27.559715' article_processing_charge: No author: - first_name: Diego Fernando full_name: Garcia Castillo, Diego Fernando id: ae681a14-dc74-11ea-a0a7-c6ef18161701 last_name: Garcia Castillo - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 - first_name: Rui full_name: Faria, Rui last_name: Faria - first_name: Jenny full_name: Larsson, Jenny last_name: Larsson - first_name: Sean full_name: Stankowski, Sean id: 43161670-5719-11EA-8025-FABC3DDC885E last_name: Stankowski - first_name: Roger full_name: Butlin, Roger last_name: Butlin - first_name: Kerstin full_name: Johannesson, Kerstin last_name: Johannesson - first_name: Anja M full_name: Westram, Anja M id: 3C147470-F248-11E8-B48F-1D18A9856A87 last_name: Westram orcid: 0000-0003-1050-4969 citation: ama: 'Garcia Castillo DF, Barton NH, Faria R, et al. Data and code for: Predicting rapid adaptation in time from adaptation in space: a 30-year field experiment in marine snails. 2024. doi:10.5281/ZENODO.12159343' apa: 'Garcia Castillo, D. F., Barton, N. H., Faria, R., Larsson, J., Stankowski, S., Butlin, R., … Westram, A. M. (2024). Data and code for: Predicting rapid adaptation in time from adaptation in space: a 30-year field experiment in marine snails. Zenodo. https://doi.org/10.5281/ZENODO.12159343' chicago: 'Garcia Castillo, Diego Fernando, Nicholas H Barton, Rui Faria, Jenny Larsson, Sean Stankowski, Roger Butlin, Kerstin Johannesson, and Anja M Westram. “Data and Code for: Predicting Rapid Adaptation in Time from Adaptation in Space: A 30-Year Field Experiment in Marine Snails.” Zenodo, 2024. https://doi.org/10.5281/ZENODO.12159343.' ieee: 'D. F. Garcia Castillo et al., “Data and code for: Predicting rapid adaptation in time from adaptation in space: a 30-year field experiment in marine snails.” Zenodo, 2024.' ista: 'Garcia Castillo DF, Barton NH, Faria R, Larsson J, Stankowski S, Butlin R, Johannesson K, Westram AM. 2024. Data and code for: Predicting rapid adaptation in time from adaptation in space: a 30-year field experiment in marine snails, Zenodo, 10.5281/ZENODO.12159343.' mla: 'Garcia Castillo, Diego Fernando, et al. Data and Code for: Predicting Rapid Adaptation in Time from Adaptation in Space: A 30-Year Field Experiment in Marine Snails. Zenodo, 2024, doi:10.5281/ZENODO.12159343.' short: D.F. Garcia Castillo, N.H. Barton, R. Faria, J. Larsson, S. Stankowski, R. Butlin, K. Johannesson, A.M. Westram, (2024). corr_author: '1' date_created: 2024-11-04T09:33:17Z date_published: 2024-06-19T00:00:00Z date_updated: 2026-04-16T12:20:37Z day: '19' ddc: - '570' department: - _id: NiBa doi: 10.5281/ZENODO.12159343 has_accepted_license: '1' main_file_link: - open_access: '1' url: https://doi.org/10.5281/zenodo.12159344 month: '06' oa: 1 oa_version: Published Version publisher: Zenodo related_material: record: - id: '20991' relation: used_in_publication status: public - id: '18491' relation: used_in_publication status: public status: public title: 'Data and code for: Predicting rapid adaptation in time from adaptation in space: a 30-year field experiment in marine snails' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: research_data_reference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2024' ... --- OA_place: repository OA_type: free access _id: '18503' abstract: - lang: eng text: "In 1996, Karger [Kar96] gave a startling randomized algorithm that finds a minimum-cut in a (weighted) graph in time O(m log3 n) which he termed near-linear time meaning linear (in the size of the input) times a polylogarthmic factor. In this paper, we give the first deterministic algorithm which runs in near-linear time for weighted graphs.\r\nPreviously, the breakthrough results of Kawarabayashi and Thorup [KT19] gave a near-linear time algorithm for simple graphs (which was improved to have running time O(m log2 n log log n) in [HRW20].) The main technique here is a clustering procedure that perfectly preserves minimum cuts. Recently, Li [Li21] gave an m1+o(1) deterministic minimum-cut algorithm for weighted graphs; this form of running time has been termed “almost-linear”. Li uses almost-linear time deterministic expander decompositions which do not perfectly preserve minimum cuts, but he can use these clusterings to, in a sense, “derandomize” the methods of Karger.\r\nIn terms of techniques, we provide a structural theorem that says there exists a sparse clustering that preserves minimum cuts in a weighted graph with o(1) error. In addition, we construct it deterministically in near linear time. This was done exactly for simple graphs in [KT19, HRW20] and with polylogarithmic error for weighted graphs in [Li21]. Extending the techniques in [KT19, HRW20] to weighted graphs presents significant challenges, and moreover, the algorithm can only polylogarithmically approximately preserve minimum cuts. A remaining challenge is to reduce the polylogarithmic-approximate clusterings to 1 + o(1/ log n)-approximate so that they can be applied recursively as in [Li21] over O(log n) many levels. This is an additional challenge that requires building on properties of tree-packings in the presence of a wide range of edge weights to, for example, find sources for local flow computations which identify minimum cuts that cross clusters." acknowledgement: This project has received funding from the European Research Council(ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 101019564 “The Design of Modern Fully Dynamic Data Structures (MoDyn-Struct)” and the Austrian Science Fund (FWF) project Z 422-N, project “Static and Dynamic Hierarchical Graph Decompositions”, I 5982-N, and project “Fast Algorithms for a Reactive Network Layer (ReactNet)”, P33775-N, with additional funding from the netidee SCIENCE Stiftung, 2020–2024. article_processing_charge: No arxiv: 1 author: - first_name: Monika H full_name: Henzinger, Monika H id: 540c9bbd-f2de-11ec-812d-d04a5be85630 last_name: Henzinger orcid: 0000-0002-5008-6530 - first_name: Jason full_name: Li, Jason last_name: Li - first_name: Satish full_name: Rao, Satish last_name: Rao - first_name: Di full_name: Wang, Di last_name: Wang citation: ama: 'Henzinger M, Li J, Rao S, Wang D. Deterministic near-linear time minimum cut in weighted graphs. In: 35th Annual ACM-SIAM Symposium on Discrete Algorithms. Society for Industrial and Applied Mathematics; 2024:3089-3139. doi:10.1137/1.9781611977912.111' apa: 'Henzinger, M., Li, J., Rao, S., & Wang, D. (2024). Deterministic near-linear time minimum cut in weighted graphs. In 35th Annual ACM-SIAM Symposium on Discrete Algorithms (pp. 3089–3139). Alexandria, VA,  United States: Society for Industrial and Applied Mathematics. https://doi.org/10.1137/1.9781611977912.111' chicago: Henzinger, Monika, Jason Li, Satish Rao, and Di Wang. “Deterministic Near-Linear Time Minimum Cut in Weighted Graphs.” In 35th Annual ACM-SIAM Symposium on Discrete Algorithms, 3089–3139. Society for Industrial and Applied Mathematics, 2024. https://doi.org/10.1137/1.9781611977912.111. ieee: M. Henzinger, J. Li, S. Rao, and D. Wang, “Deterministic near-linear time minimum cut in weighted graphs,” in 35th Annual ACM-SIAM Symposium on Discrete Algorithms, Alexandria, VA,  United States, 2024, pp. 3089–3139. ista: 'Henzinger M, Li J, Rao S, Wang D. 2024. Deterministic near-linear time minimum cut in weighted graphs. 35th Annual ACM-SIAM Symposium on Discrete Algorithms. SODA: Symposium on Discrete Algorithms, 3089–3139.' mla: Henzinger, Monika, et al. “Deterministic Near-Linear Time Minimum Cut in Weighted Graphs.” 35th Annual ACM-SIAM Symposium on Discrete Algorithms, Society for Industrial and Applied Mathematics, 2024, pp. 3089–139, doi:10.1137/1.9781611977912.111. short: M. Henzinger, J. Li, S. Rao, D. Wang, in:, 35th Annual ACM-SIAM Symposium on Discrete Algorithms, Society for Industrial and Applied Mathematics, 2024, pp. 3089–3139. conference: end_date: 2024-01-10 location: Alexandria, VA, United States name: 'SODA: Symposium on Discrete Algorithms' start_date: 2024-01-07 corr_author: '1' date_created: 2024-11-04T10:54:21Z date_published: 2024-01-04T00:00:00Z date_updated: 2025-06-24T12:09:26Z day: '04' department: - _id: MoHe doi: 10.1137/1.9781611977912.111 ec_funded: 1 external_id: arxiv: - '2401.05627' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2401.05627 month: '01' oa: 1 oa_version: Preprint page: 3089-3139 project: - _id: bd9ca328-d553-11ed-ba76-dc4f890cfe62 call_identifier: H2020 grant_number: '101019564' name: The design and evaluation of modern fully dynamic data structures - _id: 34def286-11ca-11ed-8bc3-da5948e1613c grant_number: Z00422 name: Efficient algorithms - _id: bda196b2-d553-11ed-ba76-8e8ee6c21103 grant_number: I05982 name: Static and Dynamic Hierarchical Graph Decompositions - _id: bd9e3a2e-d553-11ed-ba76-8aa684ce17fe grant_number: P33775 name: Fast Algorithms for a Reactive Network Layer publication: 35th Annual ACM-SIAM Symposium on Discrete Algorithms publication_identifier: eisbn: - '9781611977912' publication_status: published publisher: Society for Industrial and Applied Mathematics quality_controlled: '1' scopus_import: '1' status: public title: Deterministic near-linear time minimum cut in weighted graphs type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2024' ... --- OA_place: publisher OA_type: gold _id: '18515' abstract: - lang: eng text: "Understanding the role of evolutionary processes in shaping genetic variation has been a\r\nprimary goal in evolutionary genetics. In this regard, a key question is how genetically\r\ndistinct populations evolve in the face of gene flow, thereby generating genetic and\r\nphenotypic divergence and reproductive isolation (RI). This requires quantifying the role\r\nand relative contributions of prezygotic and postzygotic isolating mechanisms on the\r\nreduction of gene exchange between populations, and identifying regions in the genome\r\nthat mediate RI, which is often polygenic. Further, this needs distinguishing neutral and\r\nselected regions in the genome, and discerning how selection influences patterns of neutral\r\ndivergence.\r\nPopulation structure, defined as any deviation from panmixia, such as geographic distribution, movement and mating patterns of individuals, influences how genetic variation is\r\nstructured in space and shapes the neutral null model. Availability of large scale spatial\r\ngenomic datasets now enables us to detect signatures of population structure in genetic\r\ndata and infer population genetic parameters. Such inferences are crucial and have wide\r\napplications in biodiversity, conservation genetics, population management and medical\r\ngenetics. However, inferences are based on assumptions that do not always match the\r\ncomplex reality, thus leading to erroneous conclusions. Moreover, the role and interaction\r\nof heterogeneous population density and dispersal, which are ubiquitous in nature, has\r\nbeen challenging to study owing to their mathematical complexity. In such scenarios,\r\nfeedback between theory, data and simulations can prove to be useful.\r\nIn this thesis, I examine the effect of population structure on neutral genetic variation\r\nand barriers to gene exchange in hybridising populations, thereby bridging together the\r\nfields of spatial population genetics and speciation.\r\nDespite being a key concept in speciation, reproductive isolation (RI) lacks a quantitative\r\ndefinition and has been used and measured differently across different fields. Chapter 2\r\ngives a quantitative definition of RI, in terms of the effect of genetic differences on gene\r\nflow. We give analytical predictions for RI in a range of scenarios, in terms of effective migration rates for discrete populations and barrier strength for continuous populations.\r\nIn addition to this, we discuss current measures of RI and their limitations, and propose\r\nthe need for new measures that combine organismal and genetic perspectives of RI.\r\nIn chapter 3, I examine the combined effect of assortative mating, sexual selection\r\nand viability selection on RI. For this, we consider a polygenic ‘magic’ trait under a\r\nmainland-island model. We obtain novel theoretical predictions for molecular divergence\r\nin terms of effective migration rates, which bears a simple relationship to measurable\r\nfitness components of migrants and various early generation hybrids. We explore the\r\nconditions under which local adaptation can be maintained despite maladaptive gene flow\r\nand quantify the relative contributions of viability and sexual selection to genome-wide\r\nbarriers to gene flow.\r\nThe next two chapters of the thesis focus on a hybrid zone of Antirrhinum majus that\r\nconsist of two subspecies- the magenta flowered A. m. pseudomajus and the yellow\r\nflowered A.m. striatum. Previous studies have suggested that flower colour is target of\r\npollinator mediated selection and is influenced only by few genes. While these regions\r\nshow high genetic differentiation between the subspecies, the rest of the genome is seen\r\nto be well mixed. Chapter 4 examines the effects of heterogeneous population density\r\nand leptokurtic dispersal on isolation by distance and the distribution of heterozygosity\r\nby focusing on non-flower colour markers.\r\nChapter 5 analyses cline shapes and associations among 6 focal flower colour markers to\r\nunderstand how selection and dispersal maintain this hybrid zone. We see sharp coincident\r\nstepped clines at all loci and positive associations throughout the hybrid zone, contrary to\r\nthe expected patterns from diffusive gene flow. With a novel scheme of inferring dispersal\r\ncombined with multilocus simulations, we show that stepped clines do not reflect genetic\r\nbarriers to gene flow, but are rather a result of long-distance migration. This framework\r\nallows us to get realistic estimates gene flow and selection and shows how traditional cline\r\nanalysis may lead to inaccurate conclusions when assumptions of the theory are not met.\r\nOverall, this thesis investigates how different features of population structure leave\r\ndetectable signatures in genetic variation, namely in patterns of isolation by distance,\r\nlinkage disequilibrium and genetic divergence. It also highlights how effective migration\r\nrates provide useful way of analysing polygenic architectures and shed new light into\r\nhybrid zones. In doing so, I identify scenarios when simple models become insufficient\r\nand suggest possibe directions by combining genetic data with simulations." acknowledged_ssus: - _id: ScienComp acknowledgement: "I also acknowledge the funding agencies Marie Curie COFUND Doctoral Fellowship,\r\nAustrian Science Fund FWF (grant P32166) and ERC (grant PR1000ERC02) for financially\r\nsupporting my research over the years." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Parvathy full_name: Surendranadh, Parvathy id: 455235B8-F248-11E8-B48F-1D18A9856A87 last_name: Surendranadh orcid: 0000-0001-6395-386X citation: ama: Surendranadh P. Effect of population structure on neutral genetic variation and barriers to gene exchange. 2024. doi:10.15479/at:ista:18515 apa: Surendranadh, P. (2024). Effect of population structure on neutral genetic variation and barriers to gene exchange. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:18515 chicago: Surendranadh, Parvathy. “Effect of Population Structure on Neutral Genetic Variation and Barriers to Gene Exchange.” Institute of Science and Technology Austria, 2024. https://doi.org/10.15479/at:ista:18515. ieee: P. Surendranadh, “Effect of population structure on neutral genetic variation and barriers to gene exchange,” Institute of Science and Technology Austria, 2024. ista: Surendranadh P. 2024. Effect of population structure on neutral genetic variation and barriers to gene exchange. Institute of Science and Technology Austria. mla: Surendranadh, Parvathy. Effect of Population Structure on Neutral Genetic Variation and Barriers to Gene Exchange. Institute of Science and Technology Austria, 2024, doi:10.15479/at:ista:18515. short: P. Surendranadh, Effect of Population Structure on Neutral Genetic Variation and Barriers to Gene Exchange, Institute of Science and Technology Austria, 2024. corr_author: '1' date_created: 2024-11-06T21:25:37Z date_published: 2024-11-07T00:00:00Z date_updated: 2026-04-07T12:56:52Z day: '07' ddc: - '576' degree_awarded: PhD department: - _id: GradSch - _id: NiBa doi: 10.15479/at:ista:18515 file: - access_level: open_access checksum: c32cf7bc75748d9c551d8eb70178bbec content_type: application/pdf creator: psurendr date_created: 2024-11-07T10:59:29Z date_updated: 2024-11-07T10:59:29Z file_id: '18519' file_name: PhD_Thesis__Parvathy_071124_PDFA.pdf file_size: 37019760 relation: main_file success: 1 - access_level: closed checksum: 4417e02d54084d89e75734e18caaa96d content_type: application/zip creator: psurendr date_created: 2024-11-07T10:59:42Z date_updated: 2024-11-07T10:59:42Z file_id: '18520' file_name: PhD Thesis- Parvathy_071124.zip file_size: 41198857 relation: source_file file_date_updated: 2024-11-07T10:59:42Z has_accepted_license: '1' language: - iso: eng license: https://creativecommons.org/licenses/by-nc-sa/4.0/ month: '11' oa: 1 oa_version: Published Version page: '219' project: - _id: 05959E1C-7A3F-11EA-A408-12923DDC885E grant_number: P32166 name: Snapdragon Speciation - _id: bd6958e0-d553-11ed-ba76-86eba6a76c00 grant_number: '101055327' name: Understanding the evolution of continuous genomes publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria status: public supervisor: - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 title: Effect of population structure on neutral genetic variation and barriers to gene exchange tmp: image: /images/cc_by_nc_sa.png legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) short: CC BY-NC-SA (4.0) type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2024' ... --- APC_amount: 2748 EUR OA_place: publisher OA_type: hybrid _id: '18521' abstract: - lang: eng text: In distributed systems with processes that do not share a global clock, partial synchrony is achieved by clock synchronization that guarantees bounded clock skew among all applications. Existing solutions for distributed runtime verification under partial synchrony against temporal logic specifications are exact but suffer from significant computational overhead. In this paper, we propose an approximate distributed monitoring algorithm for Signal Temporal Logic (STL) that mitigates this issue by abstracting away potential interleaving behaviors. This conservative abstraction enables a significant speedup of the distributed monitors, albeit with a tradeoff in accuracy. We address this tradeoff with a methodology that combines our approximate monitor with its exact counterpart, resulting in enhanced efficiency without sacrificing precision. We evaluate our approach with multiple experiments, showcasing its efficacy in both real-world applications and synthetic examples. acknowledgement: This work was supported in part by the ERC-2020-AdG 101020093. This work is sponsored in part by the United States NSF CCF-2118356 award. This research was partially funded by A-IQ Ready (Chips JU, grant agreement No. 101096658). alternative_title: - LNCS article_processing_charge: Yes (in subscription journal) arxiv: 1 author: - first_name: Borzoo full_name: Bonakdarpour, Borzoo last_name: Bonakdarpour - first_name: Anik full_name: Momtaz, Anik last_name: Momtaz - first_name: Dejan full_name: Nickovic, Dejan id: 41BCEE5C-F248-11E8-B48F-1D18A9856A87 last_name: Nickovic - first_name: Naci E full_name: Sarac, Naci E id: 8C6B42F8-C8E6-11E9-A03A-F2DCE5697425 last_name: Sarac citation: ama: 'Bonakdarpour B, Momtaz A, Nickovic D, Sarac NE. Approximate distributed monitoring under partial synchrony: Balancing speed & accuracy. In: 24th International Conference on Runtime Verification. Vol 15191. Springer Nature; 2024:282-301. doi:10.1007/978-3-031-74234-7_18' apa: 'Bonakdarpour, B., Momtaz, A., Nickovic, D., & Sarac, N. E. (2024). Approximate distributed monitoring under partial synchrony: Balancing speed & accuracy. In 24th International Conference on Runtime Verification (Vol. 15191, pp. 282–301). Istanbul, Turkey: Springer Nature. https://doi.org/10.1007/978-3-031-74234-7_18' chicago: 'Bonakdarpour, Borzoo, Anik Momtaz, Dejan Nickovic, and Naci E Sarac. “Approximate Distributed Monitoring under Partial Synchrony: Balancing Speed & Accuracy.” In 24th International Conference on Runtime Verification, 15191:282–301. Springer Nature, 2024. https://doi.org/10.1007/978-3-031-74234-7_18.' ieee: 'B. Bonakdarpour, A. Momtaz, D. Nickovic, and N. E. Sarac, “Approximate distributed monitoring under partial synchrony: Balancing speed & accuracy,” in 24th International Conference on Runtime Verification, Istanbul, Turkey, 2024, vol. 15191, pp. 282–301.' ista: 'Bonakdarpour B, Momtaz A, Nickovic D, Sarac NE. 2024. Approximate distributed monitoring under partial synchrony: Balancing speed & accuracy. 24th International Conference on Runtime Verification. RV: Conference on Runtime Verification, LNCS, vol. 15191, 282–301.' mla: 'Bonakdarpour, Borzoo, et al. “Approximate Distributed Monitoring under Partial Synchrony: Balancing Speed & Accuracy.” 24th International Conference on Runtime Verification, vol. 15191, Springer Nature, 2024, pp. 282–301, doi:10.1007/978-3-031-74234-7_18.' short: B. Bonakdarpour, A. Momtaz, D. Nickovic, N.E. Sarac, in:, 24th International Conference on Runtime Verification, Springer Nature, 2024, pp. 282–301. conference: end_date: 2024-10-17 location: Istanbul, Turkey name: 'RV: Conference on Runtime Verification' start_date: 2024-10-15 corr_author: '1' date_created: 2024-11-10T23:01:58Z date_published: 2024-10-12T00:00:00Z date_updated: 2026-05-20T08:43:20Z day: '12' ddc: - '000' department: - _id: ToHe - _id: GradSch doi: 10.1007/978-3-031-74234-7_18 ec_funded: 1 external_id: arxiv: - '2408.05033' isi: - '001420093700018' file: - access_level: open_access checksum: 7b8ca21b8c19ab796fa445b0e54003ca content_type: application/pdf creator: dernst date_created: 2024-11-11T09:42:28Z date_updated: 2024-11-11T09:42:28Z file_id: '18539' file_name: 2024_LNCS_Bonakdarpour.pdf file_size: 1897101 relation: main_file success: 1 file_date_updated: 2024-11-11T09:42:28Z has_accepted_license: '1' intvolume: ' 15191' isi: 1 language: - iso: eng month: '10' oa: 1 oa_version: Published Version page: 282-301 project: - _id: 62781420-2b32-11ec-9570-8d9b63373d4d call_identifier: H2020 grant_number: '101020093' name: Vigilant Algorithmic Monitoring of Software publication: 24th International Conference on Runtime Verification publication_identifier: eissn: - 1611-3349 isbn: - '9783031742330' issn: - 0302-9743 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: 'Approximate distributed monitoring under partial synchrony: Balancing speed & accuracy' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 15191 year: '2024' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '18522' abstract: - lang: eng text: The Golgi apparatus is essential for protein sorting, yet its quality control mechanisms are poorly understood. Here we show that the Dsc ubiquitin ligase complex uses its rhomboid pseudo-protease subunit, Dsc2, to assess the hydrophobic length of α-helical transmembrane domains (TMDs) at the Golgi. Thereby the Dsc complex likely interacts with orphaned ER and Golgi proteins that have shorter TMDs and ubiquitinates them for targeted degradation. Some Dsc substrates will be extracted by Cdc48 for endosome and Golgi associated proteasomal degradation (EGAD), while others will undergo ESCRT dependent vacuolar degradation. Some substrates are degraded by both, EGAD- or ESCRT pathways. The accumulation of Dsc substrates entails a specific increase in glycerophospholipids with shorter and asymmetric fatty acyl chains. Hence, the Dsc complex mediates the selective degradation of orphaned proteins at the sorting center of cells, which prevents their spreading across other organelles and thereby preserves cellular membrane protein and lipid composition. acknowledgement: 'We thank Snezhana Oliferenko, Hesso Farhan, Chris Dunworth, and Lukas A Huber for critically reading the manuscript, Ming Li, Peter Espenshade, Sebastien Leon, and Scott Emr for reagents, Bob Kaufmann for help in characterizing the Dsc2 L1 loop mutant. This research was funded in part by the Austrian Science Fund (FWF) (10.55776/P32161, 10.55776/P34907, 10.55776/DOC82 to DT, and 10.55776/P36187 to OS), by a Lipotype lipidomics excellence award (LEA 2019) to OS, by a Luxembourg National Research Fund (FNR): Grant #13571826 to YW, and by European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 847681 (to KRL). For open access purposes, the author has applied a CC BY public copyright license to any author accepted manuscript version arising from this submission.' article_number: '9257' article_processing_charge: Yes article_type: original author: - first_name: Yannick full_name: Weyer, Yannick last_name: Weyer - first_name: Sinead I. full_name: Schwabl, Sinead I. last_name: Schwabl - first_name: Xuechen full_name: Tang, Xuechen last_name: Tang - first_name: Astha full_name: Purwar, Astha last_name: Purwar - first_name: Konstantin full_name: Siegmann, Konstantin last_name: Siegmann - first_name: Angela full_name: Ruepp, Angela last_name: Ruepp - first_name: Theresia full_name: Dunzendorfer-Matt, Theresia last_name: Dunzendorfer-Matt - first_name: Michael A. full_name: Widerin, Michael A. last_name: Widerin - first_name: Veronika full_name: Niedrist, Veronika last_name: Niedrist - first_name: Noa J.M. full_name: Mutsters, Noa J.M. last_name: Mutsters - first_name: Maria G. full_name: Tettamanti, Maria G. last_name: Tettamanti - first_name: Sabine full_name: Weys, Sabine id: caffa136-9669-11ed-9092-ceac12ac9c05 last_name: Weys - first_name: Bettina full_name: Sarg, Bettina last_name: Sarg - first_name: Leopold full_name: Kremser, Leopold last_name: Kremser - first_name: Klaus R. full_name: Liedl, Klaus R. last_name: Liedl - first_name: Oliver full_name: Schmidt, Oliver last_name: Schmidt - first_name: David full_name: Teis, David last_name: Teis citation: ama: Weyer Y, Schwabl SI, Tang X, et al. The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi. Nature Communications. 2024;15. doi:10.1038/s41467-024-53676-6 apa: Weyer, Y., Schwabl, S. I., Tang, X., Purwar, A., Siegmann, K., Ruepp, A., … Teis, D. (2024). The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-024-53676-6 chicago: Weyer, Yannick, Sinead I. Schwabl, Xuechen Tang, Astha Purwar, Konstantin Siegmann, Angela Ruepp, Theresia Dunzendorfer-Matt, et al. “The Dsc Ubiquitin Ligase Complex Identifies Transmembrane Degrons to Degrade Orphaned Proteins at the Golgi.” Nature Communications. Springer Nature, 2024. https://doi.org/10.1038/s41467-024-53676-6. ieee: Y. Weyer et al., “The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi,” Nature Communications, vol. 15. Springer Nature, 2024. ista: Weyer Y, Schwabl SI, Tang X, Purwar A, Siegmann K, Ruepp A, Dunzendorfer-Matt T, Widerin MA, Niedrist V, Mutsters NJM, Tettamanti MG, Weys S, Sarg B, Kremser L, Liedl KR, Schmidt O, Teis D. 2024. The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi. Nature Communications. 15, 9257. mla: Weyer, Yannick, et al. “The Dsc Ubiquitin Ligase Complex Identifies Transmembrane Degrons to Degrade Orphaned Proteins at the Golgi.” Nature Communications, vol. 15, 9257, Springer Nature, 2024, doi:10.1038/s41467-024-53676-6. short: Y. Weyer, S.I. Schwabl, X. Tang, A. Purwar, K. Siegmann, A. Ruepp, T. Dunzendorfer-Matt, M.A. Widerin, V. Niedrist, N.J.M. Mutsters, M.G. Tettamanti, S. Weys, B. Sarg, L. Kremser, K.R. Liedl, O. Schmidt, D. Teis, Nature Communications 15 (2024). date_created: 2024-11-10T23:01:58Z date_published: 2024-12-01T00:00:00Z date_updated: 2026-03-05T11:20:12Z day: '01' ddc: - '570' doi: 10.1038/s41467-024-53676-6 external_id: isi: - '001345548100007' pmid: - '39461958' file: - access_level: open_access checksum: 32c986fc3babec999c03a5c043310f40 content_type: application/pdf creator: dernst date_created: 2025-01-22T14:36:33Z date_updated: 2025-01-22T14:36:33Z file_id: '18870' file_name: 2024_NatureComm_Weyer.pdf file_size: 5634494 relation: main_file success: 1 file_date_updated: 2025-01-22T14:36:33Z has_accepted_license: '1' intvolume: ' 15' isi: 1 language: - iso: eng month: '12' oa: 1 oa_version: Published Version pmid: 1 publication: Nature Communications publication_identifier: eissn: - 2041-1723 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 15 year: '2024' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '18523' abstract: - lang: eng text: "Recent observations from the EIGER JWST program have measured for the first time the quasar–galaxy cross-correlation function at z ≈ 6. The autocorrelation function of faint z ≈ 6 quasars was also recently estimated. These measurements provide key insights into the properties of quasars and galaxies at high redshift and their relation with the host dark matter haloes. In this work, we interpret these data building upon an empirical quasar population model that has been applied successfully to quasar clustering and demographic measurements at z ≈ 2–4. We use a new, large-volume N-body simulation with more than a trillion particles, FLAMINGO-10k, to model quasars and galaxies simultaneously. We successfully reproduce observations of z ≈ 6 quasars and galaxies (i.e. their clustering properties and luminosity functions), and infer key quantities such as their luminosity–halo mass relation, the mass function of their host haloes, and their duty cycle/occupation fraction. Our key findings\r\nare (i) quasars reside on average in ≈ 1012.5 M haloes (corresponding to ≈ 5σ fluctuations in the initial conditions of the linear density field), but the distribution of host halo masses is quite broad; (ii) the duty cycle of (UV-bright) quasar activity is relatively low (≈ 1 per cent); (iii) galaxies (that are bright in [O III]) live in much smaller haloes (≈ 1010.9 M) and have a larger duty cycle (occupation fraction) of ≈ 13 per cent. Finally, we focus on the inferred properties of quasars and present a homogeneous analysis of their evolution with redshift. The picture that emerges reveals a strong evolution of the host halo mass and duty cycle of quasars at z ≈ 2–6, and calls for new investigations of the role of quasar activity across cosmic time." acknowledgement: "We are grateful to Junya Arita and the SHELLQs team for sharing their data on the quasar autocorrelation function and to Jan-Torge Schindler for discussion on the QLF. We acknowledge helpful conversations with the ENIGMA group at UC Santa Barbara and Leiden University. EP is grateful to Rob McGibbon and Victor Forouhar Moreno for help with the simulation outputs, and to Timo Kist, Jiamu Huang, and Vikram Khaire for comments on an early version of the manuscript. JFH and EP acknowledge support from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No 885301). This work is partly supported by funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 860744 (BiD4BESt). FW acknowledges support from NSF grant AST-2308258. This work used the DiRAC Memory Intensive service (Cosma8) at the University of Durham, which is part of the STFC DiRAC HPC Facility (www.dirac.ac.uk). Access to DiRAC resources was granted through a Director’s Discretionary Time allocation in 2023/24, under the auspices of the UKRI-funded\r\nDiRAC Federation Project. The equipment was funded by BEIS capital funding via STFC capital grants ST/K00042X/1, ST/P002293/1, ST/R002371/1, and ST/S002502/1, Durham University, and STFC operations grant ST/R000832/1. DiRAC is part of the National e-Infrastructure." article_processing_charge: Yes article_type: original author: - first_name: Elia full_name: Pizzati, Elia last_name: Pizzati - first_name: Joseph F. full_name: Hennawi, Joseph F. last_name: Hennawi - first_name: Joop full_name: Schaye, Joop last_name: Schaye - first_name: Matthieu full_name: Schaller, Matthieu last_name: Schaller - first_name: Anna Christina full_name: Eilers, Anna Christina last_name: Eilers - first_name: Feige full_name: Wang, Feige last_name: Wang - first_name: Carlos S. full_name: Frenk, Carlos S. last_name: Frenk - first_name: Willem full_name: Elbers, Willem last_name: Elbers - first_name: John C. full_name: Helly, John C. last_name: Helly - first_name: Ruari full_name: Mackenzie, Ruari last_name: Mackenzie - first_name: Jorryt J full_name: Matthee, Jorryt J id: 7439a258-f3c0-11ec-9501-9df22fe06720 last_name: Matthee orcid: 0000-0003-2871-127X - first_name: Rongmon full_name: Bordoloi, Rongmon last_name: Bordoloi - first_name: Daichi full_name: Kashino, Daichi last_name: Kashino - first_name: Rohan P. full_name: Naidu, Rohan P. last_name: Naidu - first_name: Minghao full_name: Yue, Minghao last_name: Yue citation: ama: Pizzati E, Hennawi JF, Schaye J, et al. A unified model for the clustering of quasars and galaxies at z ≈ 6. Monthly Notices of the Royal Astronomical Society. 2024;534(4):3155-3175. doi:10.1093/mnras/stae2307 apa: Pizzati, E., Hennawi, J. F., Schaye, J., Schaller, M., Eilers, A. C., Wang, F., … Yue, M. (2024). A unified model for the clustering of quasars and galaxies at z ≈ 6. Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/stae2307 chicago: Pizzati, Elia, Joseph F. Hennawi, Joop Schaye, Matthieu Schaller, Anna Christina Eilers, Feige Wang, Carlos S. Frenk, et al. “A Unified Model for the Clustering of Quasars and Galaxies at z ≈ 6.” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2024. https://doi.org/10.1093/mnras/stae2307. ieee: E. Pizzati et al., “A unified model for the clustering of quasars and galaxies at z ≈ 6,” Monthly Notices of the Royal Astronomical Society, vol. 534, no. 4. Oxford University Press, pp. 3155–3175, 2024. ista: Pizzati E, Hennawi JF, Schaye J, Schaller M, Eilers AC, Wang F, Frenk CS, Elbers W, Helly JC, Mackenzie R, Matthee JJ, Bordoloi R, Kashino D, Naidu RP, Yue M. 2024. A unified model for the clustering of quasars and galaxies at z ≈ 6. Monthly Notices of the Royal Astronomical Society. 534(4), 3155–3175. mla: Pizzati, Elia, et al. “A Unified Model for the Clustering of Quasars and Galaxies at z ≈ 6.” Monthly Notices of the Royal Astronomical Society, vol. 534, no. 4, Oxford University Press, 2024, pp. 3155–75, doi:10.1093/mnras/stae2307. short: E. Pizzati, J.F. Hennawi, J. Schaye, M. Schaller, A.C. Eilers, F. Wang, C.S. Frenk, W. Elbers, J.C. Helly, R. Mackenzie, J.J. Matthee, R. Bordoloi, D. Kashino, R.P. Naidu, M. Yue, Monthly Notices of the Royal Astronomical Society 534 (2024) 3155–3175. date_created: 2024-11-10T23:01:58Z date_published: 2024-11-01T00:00:00Z date_updated: 2025-09-08T14:40:22Z day: '01' ddc: - '520' department: - _id: JoMa doi: 10.1093/mnras/stae2307 external_id: isi: - '001335663900008' file: - access_level: open_access checksum: 9ea6285dd1d04d7a9e7b40a4c9e11edb content_type: application/pdf creator: dernst date_created: 2024-11-12T07:17:26Z date_updated: 2024-11-12T07:17:26Z file_id: '18542' file_name: 2024_MonthlyNRoyalAstronSoc_Pizzati.pdf file_size: 2954312 relation: main_file success: 1 file_date_updated: 2024-11-12T07:17:26Z has_accepted_license: '1' intvolume: ' 534' isi: 1 issue: '4' language: - iso: eng month: '11' oa: 1 oa_version: Published Version page: 3155-3175 publication: Monthly Notices of the Royal Astronomical Society publication_identifier: eissn: - 1365-2966 issn: - 0035-8711 publication_status: published publisher: Oxford University Press quality_controlled: '1' scopus_import: '1' status: public title: A unified model for the clustering of quasars and galaxies at z ≈ 6 tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 534 year: '2024' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '18524' abstract: - lang: eng text: Recent works have constrained the binary fraction of evolved populations of massive stars in local galaxies such as red supergiants and Wolf–Rayet stars, but the binary fraction of yellow supergiants (YSGs) in the Hertzsprung gap remains unconstrained. Binary evolution theory predicts that the Hertzsprung gap is home to multiple populations of binary systems with varied evolutionary histories. In this paper, we develop a method to distinguish single YSGs from YSG plus O- or B-type main-sequence binaries using optical and ultraviolet photometry, and then apply this method to identify candidate YSG binaries in the Magellanic Clouds. After constructing a set of combined stellar atmosphere models, we find that optical photometry is, given typical measurement and reddening uncertainties, sufficient to discern single YSGs from YSG+OB binaries if the OB-star is at least ∼5M⊙ for Teff,YSG ∼ 4000 K, but requires a ∼20M⊙ OB star for YSGs up to Teff,YSG ∼ 9000 K. For these hotter YSG temperatures, ultraviolet photometry allows binaries with OB companions as small as ∼7M⊙ to be identified. We use color–color spaces developed from these models to search for evidence of excess blue or ultraviolet light in a set of ∼1000 YSG candidates in the Magellanic Clouds. We identify hundreds of candidate YSG binary systems and report a preliminary fraction of YSGs that show a blue/UV color excess of 20%–60%. Spectroscopic follow-up is now required to confirm the true nature of this population. acknowledgement: "The authors thank Aaron Tohuvavohu, Katie Breivik, Marten van Kerkwijk, Jakub Klencki, Eva Laplace, and Dae-Sik Moon for helpful discussions, and Adiv Paradise for helpful edits. The authors also thank the anonymous reviewer for a helpful and constructive referee report.\r\nThe authors at the University of Toronto acknowledge that the land on which the University of Toronto operates is the traditional territory of the Huron–Wendat, the Seneca, and the Mississaugas of the Credit River. They are grateful to have the opportunity to work on this land.\r\nThe Dunlap Institute is funded through an endowment established by the David Dunlap family and the University of Toronto.\r\nA.J.G.O. is supported by a McWilliams Fellowship at Carnegie Mellon University. M.R.D. acknowledges support from the NSERC through grant RGPIN-2019-06186, the Canada Research Chairs Program, and the Dunlap Institute at the University of Toronto. B.M.G. acknowledges the support of the Natural Sciences and Engineering Research Council of Canada (NSERC) through grant RGPIN-2022-03163, and of the Canada Research Chairs program. Support for this work was provided by NASA through the NASA Hubble Fellowship Program grant Nos. HST-HF2-51457.001-A and HST-HF2-51516 awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., for NASA, under contract NAS5-26555.\r\nThis research has made use of the SIMBAD database (M. Wenger et al. 2000), operated at CDS, Strasbourg, France, and the SVO Filter Profile Service 13 supported by the Spanish MINECO through grant AYA2017-84089 (C. Rodrigo et al. 2012, 2020).\r\nThis research has made use of the following software: astropy (Astropy Collaboration et al. 2013, 2018, 2022), IRAF (D. Tody 1986, 1993), and TOPCAT (M. B. Taylor 2005)." article_number: '29' article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Anna J.G. full_name: O’Grady, Anna J.G. last_name: O’Grady - first_name: Maria R. full_name: Drout, Maria R. last_name: Drout - first_name: Kathryn F. full_name: Neugent, Kathryn F. last_name: Neugent - first_name: Bethany full_name: Ludwig, Bethany last_name: Ludwig - first_name: Ylva Louise Linsdotter full_name: Götberg, Ylva Louise Linsdotter id: d0648d0c-0f64-11ee-a2e0-dd0faa2e4f7d last_name: Götberg orcid: 0000-0002-6960-6911 - first_name: B. M. full_name: Gaensler, B. M. last_name: Gaensler citation: ama: O’Grady AJG, Drout MR, Neugent KF, Ludwig B, Götberg YLL, Gaensler BM. Binary yellow supergiants in the Magellanic Clouds. I. Photometric candidate identification. Astrophysical Journal. 2024;975. doi:10.3847/1538-4357/ad778a apa: O’Grady, A. J. G., Drout, M. R., Neugent, K. F., Ludwig, B., Götberg, Y. L. L., & Gaensler, B. M. (2024). Binary yellow supergiants in the Magellanic Clouds. I. Photometric candidate identification. Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ad778a chicago: O’Grady, Anna J.G., Maria R. Drout, Kathryn F. Neugent, Bethany Ludwig, Ylva Louise Linsdotter Götberg, and B. M. Gaensler. “Binary Yellow Supergiants in the Magellanic Clouds. I. Photometric Candidate Identification.” Astrophysical Journal. IOP Publishing, 2024. https://doi.org/10.3847/1538-4357/ad778a. ieee: A. J. G. O’Grady, M. R. Drout, K. F. Neugent, B. Ludwig, Y. L. L. Götberg, and B. M. Gaensler, “Binary yellow supergiants in the Magellanic Clouds. I. Photometric candidate identification,” Astrophysical Journal, vol. 975. IOP Publishing, 2024. ista: O’Grady AJG, Drout MR, Neugent KF, Ludwig B, Götberg YLL, Gaensler BM. 2024. Binary yellow supergiants in the Magellanic Clouds. I. Photometric candidate identification. Astrophysical Journal. 975, 29. mla: O’Grady, Anna J. G., et al. “Binary Yellow Supergiants in the Magellanic Clouds. I. Photometric Candidate Identification.” Astrophysical Journal, vol. 975, 29, IOP Publishing, 2024, doi:10.3847/1538-4357/ad778a. short: A.J.G. O’Grady, M.R. Drout, K.F. Neugent, B. Ludwig, Y.L.L. Götberg, B.M. Gaensler, Astrophysical Journal 975 (2024). date_created: 2024-11-10T23:01:59Z date_published: 2024-11-01T00:00:00Z date_updated: 2025-09-08T14:37:18Z day: '01' ddc: - '520' department: - _id: YlGo doi: 10.3847/1538-4357/ad778a external_id: arxiv: - '2406.17177' isi: - '001339486900001' file: - access_level: open_access checksum: 0e9bb88b5048ecc782ac27953c84b8ce content_type: application/pdf creator: dernst date_created: 2024-11-11T09:20:45Z date_updated: 2024-11-11T09:20:45Z file_id: '18535' file_name: 2024_AstrophysicalJour_Grady.pdf file_size: 34634395 relation: main_file success: 1 file_date_updated: 2024-11-11T09:20:45Z has_accepted_license: '1' intvolume: ' 975' isi: 1 language: - iso: eng month: '11' oa: 1 oa_version: Published Version publication: Astrophysical Journal publication_identifier: eissn: - 1538-4357 issn: - 0004-637X publication_status: published publisher: IOP Publishing quality_controlled: '1' scopus_import: '1' status: public title: Binary yellow supergiants in the Magellanic Clouds. I. Photometric candidate identification tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 975 year: '2024' ... --- APC_amount: 3062,93 EUR OA_place: publisher OA_type: hybrid _id: '18525' abstract: - lang: eng text: As their statistical power grows, genome-wide association studies (GWAS) have identified an increasing number of loci underlying quantitative traits of interest. These loci are scattered throughout the genome and are individually responsible only for small fractions of the total heritable trait variance. The recently proposed omnigenic model provides a conceptual framework to explain these observations by postulating that numerous distant loci contribute to each complex trait via effect propagation through intracellular regulatory networks. We formalize this conceptual framework by proposing the “quantitative omnigenic model” (QOM), a statistical model that combines prior knowledge of the regulatory network topology with genomic data. By applying our model to gene expression traits in yeast, we demonstrate that QOM achieves similar gene expression prediction performance to traditional GWAS with hundreds of times less parameters, while simultaneously extracting candidate causal and quantitative chains of effect propagation through the regulatory network for every individual gene. We estimate the fraction of heritable trait variance in cis- and in trans-, break the latter down by effect propagation order, assess the trans- variance not attributable to transcriptional regulation, and show that QOM correctly accounts for the low-dimensional structure of gene expression covariance. We furthermore demonstrate the relevance of QOM for systems biology, by employing it as a statistical test for the quality of regulatory network reconstructions, and linking it to the propagation of nontranscriptional (including environmental) effects. acknowledgement: N.R.acknowledges the support of the Austrian Academy of Sciences through the Doctoral Fellowship Programme (DOC) of the Austrian Academy of Sciences 26917. M.H. and G.T. were supported in part by the Human Frontiers Science Program Grant RGP0034/2018. We thank Nicholas H. Barton, Fyodor Kondrashov, and Matthew R. Robinson for fruitful discussions. article_number: e2402340121 article_processing_charge: Yes article_type: original author: - first_name: Natalia full_name: Ruzickova, Natalia id: D2761128-D73D-11E9-A1BF-BA0DE6697425 last_name: Ruzickova - first_name: Michal full_name: Hledik, Michal id: 4171253A-F248-11E8-B48F-1D18A9856A87 last_name: Hledik - first_name: Gašper full_name: Tkačik, Gašper id: 3D494DCA-F248-11E8-B48F-1D18A9856A87 last_name: Tkačik orcid: 0000-0002-6699-1455 citation: ama: Ruzickova N, Hledik M, Tkačik G. Quantitative omnigenic model discovers interpretable genome-wide associations. Proceedings of the National Academy of Sciences of the United States of America. 2024;121(44). doi:10.1073/pnas.2402340121 apa: Ruzickova, N., Hledik, M., & Tkačik, G. (2024). Quantitative omnigenic model discovers interpretable genome-wide associations. Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences. https://doi.org/10.1073/pnas.2402340121 chicago: Ruzickova, Natalia, Michal Hledik, and Gašper Tkačik. “Quantitative Omnigenic Model Discovers Interpretable Genome-Wide Associations.” Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences, 2024. https://doi.org/10.1073/pnas.2402340121. ieee: N. Ruzickova, M. Hledik, and G. Tkačik, “Quantitative omnigenic model discovers interpretable genome-wide associations,” Proceedings of the National Academy of Sciences of the United States of America, vol. 121, no. 44. National Academy of Sciences, 2024. ista: Ruzickova N, Hledik M, Tkačik G. 2024. Quantitative omnigenic model discovers interpretable genome-wide associations. Proceedings of the National Academy of Sciences of the United States of America. 121(44), e2402340121. mla: Ruzickova, Natalia, et al. “Quantitative Omnigenic Model Discovers Interpretable Genome-Wide Associations.” Proceedings of the National Academy of Sciences of the United States of America, vol. 121, no. 44, e2402340121, National Academy of Sciences, 2024, doi:10.1073/pnas.2402340121. short: N. Ruzickova, M. Hledik, G. Tkačik, Proceedings of the National Academy of Sciences of the United States of America 121 (2024). corr_author: '1' date_created: 2024-11-10T23:01:59Z date_published: 2024-10-29T00:00:00Z date_updated: 2026-04-07T12:02:39Z day: '29' ddc: - '570' department: - _id: GaTk - _id: NiBa doi: 10.1073/pnas.2402340121 external_id: isi: - '001349462600001' pmid: - '39441639' file: - access_level: open_access checksum: d930e2ccf9ec900c7d7509a78cfb3564 content_type: application/pdf creator: dernst date_created: 2024-11-11T09:31:00Z date_updated: 2024-11-11T09:31:00Z file_id: '18536' file_name: 2024_PNAS_Ruzickova.pdf file_size: 25529709 relation: main_file success: 1 file_date_updated: 2024-11-11T09:31:00Z has_accepted_license: '1' intvolume: ' 121' isi: 1 issue: '44' language: - iso: eng license: https://creativecommons.org/licenses/by-nc-nd/4.0/ month: '10' oa: 1 oa_version: Published Version pmid: 1 project: - _id: 7bec9174-9f16-11ee-852c-ded9fe5f810e name: Collective behaviour of cells in pancreatic Islets of Langerhans - _id: 2665AAFE-B435-11E9-9278-68D0E5697425 grant_number: RGP0034/2018 name: Can evolution minimize spurious signaling crosstalk to reach optimal performance? publication: Proceedings of the National Academy of Sciences of the United States of America publication_identifier: eissn: - 1091-6490 issn: - 0027-8424 publication_status: published publisher: National Academy of Sciences quality_controlled: '1' related_material: record: - id: '20357' relation: dissertation_contains status: public scopus_import: '1' status: public title: Quantitative omnigenic model discovers interpretable genome-wide associations tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 121 year: '2024' ... --- OA_place: publisher OA_type: hybrid _id: '18526' abstract: - lang: eng text: Multivesicular endosomes (MVEs) sequester membrane proteins destined for degradation within intralumenal vesicles (ILVs), a process mediated by the membrane-remodeling action of Endosomal Sorting Complex Required for Transport (ESCRT) proteins. In Arabidopsis, endosomal membrane constriction and scission are uncoupled, resulting in the formation of extensive concatenated ILV networks and enhancing cargo sequestration efficiency. Here, we used a combination of electron tomography, computer simulations, and mathematical modeling to address the questions of when concatenated ILV networks evolved in plants and what drives their formation. Through morphometric analyses of tomographic reconstructions of endosomes across yeast, algae, and various land plants, we have found that ILV concatenation is widespread within plant species, but only prevalent in seed plants, especially in flowering plants. Multiple budding sites that require the formation of pores in the limiting membrane were only identified in hornworts and seed plants, suggesting that this mechanism has evolved independently in both plant lineages. To identify the conditions under which these multiple budding sites can arise, we used particle-based molecular dynamics simulations and found that changes in ESCRT filament properties, such as filament curvature and membrane binding energy, can generate the membrane shapes observed in multiple budding sites. To understand the relationship between membrane budding activity and ILV network topology, we performed computational simulations and identified a set of membrane remodeling parameters that can recapitulate our tomographic datasets. acknowledgement: We would like to thank Janice Pennington for her support with electron tomography data collection, Dr. Ingrid Jordon-Thaden, director of the Botany Garden and Greenhouse of University of Wisconsin Madison, for her invaluable assistance collecting plant materials, Dr. Marie Trest for providing Chara specimens, and Dr. Nicholas Keuler for his advice on statistical analyses. We thank Charlie Hamilton for exploring the initial computational model. This work was supported by grant NSF MCB 2114603 and NIH 1S10OD026769-01 to M.S.O. F.F acknowledges support as a NOMIS Fellow from the NOMIS Foundation. A.Š. acknowledges ERC Starting Grant “NEPA” 802960. article_number: e2409407121 article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Ethan full_name: Weiner, Ethan last_name: Weiner - first_name: Elizabeth full_name: Berryman, Elizabeth last_name: Berryman - first_name: Felix F full_name: Frey, Felix F id: a0270b37-8f1a-11ec-95c7-8e710c59a4f3 last_name: Frey orcid: 0000-0001-8501-6017 - first_name: Ariadna González full_name: Solís, Ariadna González last_name: Solís - first_name: André full_name: Leier, André last_name: Leier - first_name: Tatiana Marquez full_name: Lago, Tatiana Marquez last_name: Lago - first_name: Anđela full_name: Šarić, Anđela id: bf63d406-f056-11eb-b41d-f263a6566d8b last_name: Šarić orcid: 0000-0002-7854-2139 - first_name: Marisa S. full_name: Otegui, Marisa S. last_name: Otegui citation: ama: Weiner E, Berryman E, Frey FF, et al. Endosomal membrane budding patterns in plants. Proceedings of the National Academy of Sciences of the United States of America. 2024;121(44). doi:10.1073/pnas.2409407121 apa: Weiner, E., Berryman, E., Frey, F. F., Solís, A. G., Leier, A., Lago, T. M., … Otegui, M. S. (2024). Endosomal membrane budding patterns in plants. Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences. https://doi.org/10.1073/pnas.2409407121 chicago: Weiner, Ethan, Elizabeth Berryman, Felix F Frey, Ariadna González Solís, André Leier, Tatiana Marquez Lago, Anđela Šarić, and Marisa S. Otegui. “Endosomal Membrane Budding Patterns in Plants.” Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences, 2024. https://doi.org/10.1073/pnas.2409407121. ieee: E. Weiner et al., “Endosomal membrane budding patterns in plants,” Proceedings of the National Academy of Sciences of the United States of America, vol. 121, no. 44. National Academy of Sciences, 2024. ista: Weiner E, Berryman E, Frey FF, Solís AG, Leier A, Lago TM, Šarić A, Otegui MS. 2024. Endosomal membrane budding patterns in plants. Proceedings of the National Academy of Sciences of the United States of America. 121(44), e2409407121. mla: Weiner, Ethan, et al. “Endosomal Membrane Budding Patterns in Plants.” Proceedings of the National Academy of Sciences of the United States of America, vol. 121, no. 44, e2409407121, National Academy of Sciences, 2024, doi:10.1073/pnas.2409407121. short: E. Weiner, E. Berryman, F.F. Frey, A.G. Solís, A. Leier, T.M. Lago, A. Šarić, M.S. Otegui, Proceedings of the National Academy of Sciences of the United States of America 121 (2024). date_created: 2024-11-10T23:01:59Z date_published: 2024-10-29T00:00:00Z date_updated: 2025-09-08T14:38:35Z day: '29' ddc: - '570' department: - _id: AnSa doi: 10.1073/pnas.2409407121 ec_funded: 1 external_id: isi: - '001349500800007' pmid: - '39441629' file: - access_level: open_access checksum: 21c82d2ab58ff99b2bd0489797be42e5 content_type: application/pdf creator: dernst date_created: 2024-11-11T09:35:15Z date_updated: 2024-11-11T09:35:15Z file_id: '18538' file_name: 2024_PNAS_Weiner.pdf file_size: 5268074 relation: main_file success: 1 file_date_updated: 2024-11-11T09:35:15Z has_accepted_license: '1' intvolume: ' 121' isi: 1 issue: '44' language: - iso: eng month: '10' oa: 1 oa_version: Published Version pmid: 1 project: - _id: eba2549b-77a9-11ec-83b8-a81e493eae4e call_identifier: H2020 grant_number: '802960' name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines' publication: Proceedings of the National Academy of Sciences of the United States of America publication_identifier: eissn: - 1091-6490 issn: - 0027-8424 publication_status: published publisher: National Academy of Sciences quality_controlled: '1' scopus_import: '1' status: public title: Endosomal membrane budding patterns in plants tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 121 year: '2024' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '18545' abstract: - lang: eng text: Clinical implementation of therapeutic genome editing relies on efficient in vivo delivery and the safety of CRISPR-Cas tools. Previously, we identified PsCas9 as a Type II-B family enzyme capable of editing mouse liver genome upon adenoviral delivery without detectable off-targets and reduced chromosomal translocations. Yet, its efficacy remains insufficient with non-viral delivery, a common challenge for many Cas9 orthologues. Here, we sought to redesign PsCas9 for in vivo editing using lipid nanoparticles. We solve the PsCas9 ribonucleoprotein structure with cryo-EM and characterize it biochemically, providing a basis for its rational engineering. Screening over numerous guide RNA and protein variants lead us to develop engineered PsCas9 (ePsCas9) with up to 20-fold increased activity across various targets and preserved safety advantages. We apply the same design principles to boost the activity of FnCas9, an enzyme phylogenetically relevant to PsCas9. Remarkably, a single administration of mRNA encoding ePsCas9 and its guide formulated with lipid nanoparticles results in high levels of editing in the Pcsk9 gene in mouse liver, a clinically relevant target for hypercholesterolemia treatment. Collectively, our findings introduce ePsCas9 as a highly efficient, and precise tool for therapeutic genome editing, in addition to the engineering strategy applicable to other Cas9 orthologues. article_number: '9173' article_processing_charge: Yes article_type: original author: - first_name: Dmitrii full_name: Degtev, Dmitrii last_name: Degtev - first_name: Jack Peter Kelly full_name: Bravo, Jack Peter Kelly id: 96aecfa5-8931-11ee-af30-aa6a5d6eee0e last_name: Bravo orcid: 0000-0003-0456-0753 - first_name: Aikaterini full_name: Emmanouilidi, Aikaterini last_name: Emmanouilidi - first_name: Aleksandar full_name: Zdravković, Aleksandar last_name: Zdravković - first_name: Oi Kuan full_name: Choong, Oi Kuan last_name: Choong - first_name: Julia full_name: Liz Touza, Julia last_name: Liz Touza - first_name: Niklas full_name: Selfjord, Niklas last_name: Selfjord - first_name: Isabel full_name: Weisheit, Isabel last_name: Weisheit - first_name: Margherita full_name: Francescatto, Margherita last_name: Francescatto - first_name: Pinar full_name: Akcakaya, Pinar last_name: Akcakaya - first_name: Michelle full_name: Porritt, Michelle last_name: Porritt - first_name: Marcello full_name: Maresca, Marcello last_name: Maresca - first_name: David full_name: Taylor, David last_name: Taylor - first_name: Grzegorz full_name: Sienski, Grzegorz last_name: Sienski citation: ama: Degtev D, Bravo JPK, Emmanouilidi A, et al. Engineered PsCas9 enables therapeutic genome editing in mouse liver with lipid nanoparticles. Nature Communications. 2024;15. doi:10.1038/s41467-024-53418-8 apa: Degtev, D., Bravo, J. P. K., Emmanouilidi, A., Zdravković, A., Choong, O. K., Liz Touza, J., … Sienski, G. (2024). Engineered PsCas9 enables therapeutic genome editing in mouse liver with lipid nanoparticles. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-024-53418-8 chicago: Degtev, Dmitrii, Jack Peter Kelly Bravo, Aikaterini Emmanouilidi, Aleksandar Zdravković, Oi Kuan Choong, Julia Liz Touza, Niklas Selfjord, et al. “Engineered PsCas9 Enables Therapeutic Genome Editing in Mouse Liver with Lipid Nanoparticles.” Nature Communications. Springer Nature, 2024. https://doi.org/10.1038/s41467-024-53418-8. ieee: D. Degtev et al., “Engineered PsCas9 enables therapeutic genome editing in mouse liver with lipid nanoparticles,” Nature Communications, vol. 15. Springer Nature, 2024. ista: Degtev D, Bravo JPK, Emmanouilidi A, Zdravković A, Choong OK, Liz Touza J, Selfjord N, Weisheit I, Francescatto M, Akcakaya P, Porritt M, Maresca M, Taylor D, Sienski G. 2024. Engineered PsCas9 enables therapeutic genome editing in mouse liver with lipid nanoparticles. Nature Communications. 15, 9173. mla: Degtev, Dmitrii, et al. “Engineered PsCas9 Enables Therapeutic Genome Editing in Mouse Liver with Lipid Nanoparticles.” Nature Communications, vol. 15, 9173, Springer Nature, 2024, doi:10.1038/s41467-024-53418-8. short: D. Degtev, J.P.K. Bravo, A. Emmanouilidi, A. Zdravković, O.K. Choong, J. Liz Touza, N. Selfjord, I. Weisheit, M. Francescatto, P. Akcakaya, M. Porritt, M. Maresca, D. Taylor, G. Sienski, Nature Communications 15 (2024). date_created: 2024-11-12T10:18:04Z date_published: 2024-11-07T00:00:00Z date_updated: 2024-11-13T08:19:50Z day: '07' ddc: - '572' doi: 10.1038/s41467-024-53418-8 extern: '1' file: - access_level: open_access checksum: dcfadc806f4144d065eb8e2032554782 content_type: application/pdf creator: jbravo date_created: 2024-11-12T10:18:32Z date_updated: 2024-11-12T10:18:32Z file_id: '18546' file_name: s41467-024-53418-8.pdf file_size: 2967001 relation: main_file success: 1 file_date_updated: 2024-11-12T10:18:32Z has_accepted_license: '1' intvolume: ' 15' language: - iso: eng month: '11' oa: 1 oa_version: Published Version publication: Nature Communications publication_identifier: issn: - 2041-1723 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: Engineered PsCas9 enables therapeutic genome editing in mouse liver with lipid nanoparticles tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 15 year: '2024' ... --- OA_place: publisher OA_type: hybrid _id: '18553' abstract: - lang: eng text: Transcription-coupled nucleotide excision repair (TC-NER) efficiently eliminates DNA damage that impedes gene transcription by RNA polymerase II (RNA Pol II). TC-NER is initiated by the recognition of lesion-stalled RNA Pol II by CSB, which recruits the CRL4CSA ubiquitin ligase and UVSSA. RNA Pol II ubiquitylation at RPB1-K1268 by CRL4CSA serves as a critical TC-NER checkpoint, governing RNA Pol II stability and initiating DNA damage excision by TFIIH recruitment. However, the precise regulatory mechanisms of CRL4CSA activity and TFIIH recruitment remain elusive. Here, we reveal human serine/threonine-protein kinase 19 (STK19) as a TC-NER factor, which is essential for correct DNA damage removal and subsequent transcription restart. Cryogenic electron microscopy (cryo-EM) studies demonstrate that STK19 is an integral part of the RNA Pol II-TC-NER complex, bridging CSA, UVSSA, RNA Pol II, and downstream DNA. STK19 stimulates TC-NER complex stability and CRL4CSA activity, resulting in efficient RNA Pol II ubiquitylation and correct UVSSA and TFIIH binding. These findings underscore the crucial role of STK19 as a core TC-NER component. acknowledged_ssus: - _id: LifeSc - _id: PreCl acknowledgement: We thank N. Thompson and R. Burgess for the 8WG16 hybridoma cell line. This research was further supported by the Scientific Service Units (SSU) of IST Austria through resources provided by the Lab Support Facility (LSF) and the Preclinical Facility (PCF). This work is part of the Oncode Institute, which is partly financed by the Dutch Cancer Society. Research at the Netherlands Cancer Institute is supported by institutional grants of the Dutch Cancer Society and the Dutch Ministry of Health, Welfare and Sport. This study was supported by a VICI (VI.C.182.025) and a TOP Grant (714.017.003) of the Netherlands Organization for Scientific Research. article_processing_charge: No article_type: original author: - first_name: Anisha R. full_name: Ramadhin, Anisha R. last_name: Ramadhin - first_name: Shun-Hsiao full_name: Lee, Shun-Hsiao last_name: Lee - first_name: Di full_name: Zhou, Di last_name: Zhou - first_name: Anita P full_name: Testa Salmazo, Anita P id: 41F1F098-F248-11E8-B48F-1D18A9856A87 last_name: Testa Salmazo - first_name: Camila full_name: Gonzalo-Hansen, Camila last_name: Gonzalo-Hansen - first_name: Marjolein full_name: van Sluis, Marjolein last_name: van Sluis - first_name: Cindy M.A. full_name: Blom, Cindy M.A. last_name: Blom - first_name: Roel C. full_name: Janssens, Roel C. last_name: Janssens - first_name: Anja full_name: Raams, Anja last_name: Raams - first_name: Dick full_name: Dekkers, Dick last_name: Dekkers - first_name: Karel full_name: Bezstarosti, Karel last_name: Bezstarosti - first_name: Dea full_name: Slade, Dea last_name: Slade - first_name: Wim full_name: Vermeulen, Wim last_name: Vermeulen - first_name: Alex full_name: Pines, Alex last_name: Pines - first_name: Jeroen A.A. full_name: Demmers, Jeroen A.A. last_name: Demmers - first_name: Carrie A full_name: Bernecky, Carrie A id: 2CB9DFE2-F248-11E8-B48F-1D18A9856A87 last_name: Bernecky orcid: 0000-0003-0893-7036 - first_name: Titia K. full_name: Sixma, Titia K. last_name: Sixma - first_name: Jurgen A. full_name: Marteijn, Jurgen A. last_name: Marteijn citation: ama: Ramadhin AR, Lee S-H, Zhou D, et al. STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment. Molecular Cell. 2024;84(24):4740-4757.e12. doi:10.1016/j.molcel.2024.10.030 apa: Ramadhin, A. R., Lee, S.-H., Zhou, D., Testa Salmazo, A. P., Gonzalo-Hansen, C., van Sluis, M., … Marteijn, J. A. (2024). STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment. Molecular Cell. Elsevier. https://doi.org/10.1016/j.molcel.2024.10.030 chicago: Ramadhin, Anisha R., Shun-Hsiao Lee, Di Zhou, Anita P Testa Salmazo, Camila Gonzalo-Hansen, Marjolein van Sluis, Cindy M.A. Blom, et al. “STK19 Drives Transcription-Coupled Repair by Stimulating Repair Complex Stability, RNA Pol II Ubiquitylation, and TFIIH Recruitment.” Molecular Cell. Elsevier, 2024. https://doi.org/10.1016/j.molcel.2024.10.030. ieee: A. R. Ramadhin et al., “STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment,” Molecular Cell, vol. 84, no. 24. Elsevier, p. 4740–4757.e12, 2024. ista: Ramadhin AR, Lee S-H, Zhou D, Testa Salmazo AP, Gonzalo-Hansen C, van Sluis M, Blom CMA, Janssens RC, Raams A, Dekkers D, Bezstarosti K, Slade D, Vermeulen W, Pines A, Demmers JAA, Bernecky C, Sixma TK, Marteijn JA. 2024. STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment. Molecular Cell. 84(24), 4740–4757.e12. mla: Ramadhin, Anisha R., et al. “STK19 Drives Transcription-Coupled Repair by Stimulating Repair Complex Stability, RNA Pol II Ubiquitylation, and TFIIH Recruitment.” Molecular Cell, vol. 84, no. 24, Elsevier, 2024, p. 4740–4757.e12, doi:10.1016/j.molcel.2024.10.030. short: A.R. Ramadhin, S.-H. Lee, D. Zhou, A.P. Testa Salmazo, C. Gonzalo-Hansen, M. van Sluis, C.M.A. Blom, R.C. Janssens, A. Raams, D. Dekkers, K. Bezstarosti, D. Slade, W. Vermeulen, A. Pines, J.A.A. Demmers, C. Bernecky, T.K. Sixma, J.A. Marteijn, Molecular Cell 84 (2024) 4740–4757.e12. date_created: 2024-11-15T12:12:54Z date_published: 2024-12-19T00:00:00Z date_updated: 2025-09-08T14:42:50Z day: '19' ddc: - '570' department: - _id: CaBe doi: 10.1016/j.molcel.2024.10.030 external_id: isi: - '001395711300001' pmid: - '39547223' file: - access_level: open_access checksum: e051e2766b2d424983778f742cb7c5ed content_type: application/pdf creator: dernst date_created: 2025-01-13T11:17:35Z date_updated: 2025-01-13T11:17:35Z file_id: '18844' file_name: 2024_MolecularCell_Ramadhin.pdf file_size: 25071994 relation: main_file success: 1 file_date_updated: 2025-01-13T11:17:35Z has_accepted_license: '1' intvolume: ' 84' isi: 1 issue: '24' language: - iso: eng month: '12' oa: 1 oa_version: Published Version page: 4740-4757.e12 pmid: 1 publication: Molecular Cell publication_identifier: issn: - 1097-2765 publication_status: published publisher: Elsevier quality_controlled: '1' scopus_import: '1' status: public title: STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 84 year: '2024' ... --- OA_place: publisher OA_type: hybrid _id: '18554' abstract: - lang: eng text: We prove the Eigenstate Thermalization Hypothesis for general Wigner-type matrices in the bulk of the self-consistent spectrum, with optimal control on the fluctuations for obs ervables of arbitrary rank. As the main technical ingredient, we prove rank-uniform optimal local laws for one and two resolvents of a Wigner-type matrix with regular observables. Our results hold under very general conditions on the variance profile, even allowing many vanishing entries, demonstrating that Eigenstate Thermalization occurs robustly across a diverse class of random matrix ensembles, for which the underlying quantum system has a non-trivial spatial structure. acknowledgement: Open access funding provided by Institute of Science and Technology (IST Austria). article_number: '282' article_processing_charge: Yes (via OA deal) article_type: original arxiv: 1 author: - first_name: László full_name: Erdös, László id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 - first_name: Volodymyr full_name: Riabov, Volodymyr id: 1949f904-edfb-11eb-afb5-e2dfddabb93b last_name: Riabov citation: ama: Erdös L, Riabov V. Eigenstate Thermalization Hypothesis for Wigner-type matrices. Communications in Mathematical Physics. 2024;405(12). doi:10.1007/s00220-024-05143-y apa: Erdös, L., & Riabov, V. (2024). Eigenstate Thermalization Hypothesis for Wigner-type matrices. Communications in Mathematical Physics. Springer Nature. https://doi.org/10.1007/s00220-024-05143-y chicago: Erdös, László, and Volodymyr Riabov. “Eigenstate Thermalization Hypothesis for Wigner-Type Matrices.” Communications in Mathematical Physics. Springer Nature, 2024. https://doi.org/10.1007/s00220-024-05143-y. ieee: L. Erdös and V. Riabov, “Eigenstate Thermalization Hypothesis for Wigner-type matrices,” Communications in Mathematical Physics, vol. 405, no. 12. Springer Nature, 2024. ista: Erdös L, Riabov V. 2024. Eigenstate Thermalization Hypothesis for Wigner-type matrices. Communications in Mathematical Physics. 405(12), 282. mla: Erdös, László, and Volodymyr Riabov. “Eigenstate Thermalization Hypothesis for Wigner-Type Matrices.” Communications in Mathematical Physics, vol. 405, no. 12, 282, Springer Nature, 2024, doi:10.1007/s00220-024-05143-y. short: L. Erdös, V. Riabov, Communications in Mathematical Physics 405 (2024). corr_author: '1' date_created: 2024-11-17T23:01:46Z date_published: 2024-12-01T00:00:00Z date_updated: 2026-04-07T12:32:19Z day: '01' ddc: - '510' department: - _id: LaEr doi: 10.1007/s00220-024-05143-y external_id: arxiv: - '2403.10359' isi: - '001348943900004' pmid: - '39526190' file: - access_level: open_access checksum: c9ae0ea195bd39b8b3a630d492fb00dc content_type: application/pdf creator: dernst date_created: 2024-11-18T08:15:07Z date_updated: 2024-11-18T08:15:07Z file_id: '18562' file_name: 2024_CommMathPhysics_Erdoes.pdf file_size: 1426046 relation: main_file success: 1 file_date_updated: 2024-11-18T08:15:07Z has_accepted_license: '1' intvolume: ' 405' isi: 1 issue: '12' language: - iso: eng month: '12' oa: 1 oa_version: Published Version pmid: 1 publication: Communications in Mathematical Physics publication_identifier: eissn: - 1432-0916 issn: - 0010-3616 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: record: - id: '20575' relation: dissertation_contains status: public scopus_import: '1' status: public title: Eigenstate Thermalization Hypothesis for Wigner-type matrices tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 405 year: '2024' ... --- OA_place: publisher OA_type: gold _id: '18556' abstract: - lang: eng text: Given a finite set, A ⊆ ℝ², and a subset, B ⊆ A, the MST-ratio is the combined length of the minimum spanning trees of B and A⧵B divided by the length of the minimum spanning tree of A. The question of the supremum, over all sets A, of the maximum, over all subsets B, is related to the Steiner ratio, and we prove this sup-max is between 2.154 and 2.427. Restricting ourselves to 2-dimensional lattices, we prove that the sup-max is 2, while the inf-max is 1.25. By some margin the most difficult of these results is the upper bound for the inf-max, which we prove by showing that the hexagonal lattice cannot have MST-ratio larger than 1.25. acknowledgement: This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme, grant no. 788183, from the Wittgenstein Prize, Austrian Science Fund (FWF), grant no. Z 342-N31, and from the DFG Collaborative Research Center TRR 109, "Discretization in Geometry and Dynamics", Austrian Science Fund (FWF), grant no. I 02979-N35. alternative_title: - LIPIcs article_number: '3' article_processing_charge: Yes arxiv: 1 author: - first_name: Sebastiano full_name: Cultrera di Montesano, Sebastiano id: 34D2A09C-F248-11E8-B48F-1D18A9856A87 last_name: Cultrera di Montesano orcid: 0000-0001-6249-0832 - first_name: Ondrej full_name: Draganov, Ondrej id: 2B23F01E-F248-11E8-B48F-1D18A9856A87 last_name: Draganov orcid: 0000-0003-0464-3823 - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 - first_name: Morteza full_name: Saghafian, Morteza id: f86f7148-b140-11ec-9577-95435b8df824 last_name: Saghafian citation: ama: 'Cultrera di Montesano S, Draganov O, Edelsbrunner H, Saghafian M. The Euclidean MST-ratio for bi-colored lattices. In: 32nd International Symposium on Graph Drawing and Network Visualization. Vol 320. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2024. doi:10.4230/LIPIcs.GD.2024.3' apa: 'Cultrera di Montesano, S., Draganov, O., Edelsbrunner, H., & Saghafian, M. (2024). The Euclidean MST-ratio for bi-colored lattices. In 32nd International Symposium on Graph Drawing and Network Visualization (Vol. 320). Vienna, Austria: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPIcs.GD.2024.3' chicago: Cultrera di Montesano, Sebastiano, Ondrej Draganov, Herbert Edelsbrunner, and Morteza Saghafian. “The Euclidean MST-Ratio for Bi-Colored Lattices.” In 32nd International Symposium on Graph Drawing and Network Visualization, Vol. 320. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2024. https://doi.org/10.4230/LIPIcs.GD.2024.3. ieee: S. Cultrera di Montesano, O. Draganov, H. Edelsbrunner, and M. Saghafian, “The Euclidean MST-ratio for bi-colored lattices,” in 32nd International Symposium on Graph Drawing and Network Visualization, Vienna, Austria, 2024, vol. 320. ista: 'Cultrera di Montesano S, Draganov O, Edelsbrunner H, Saghafian M. 2024. The Euclidean MST-ratio for bi-colored lattices. 32nd International Symposium on Graph Drawing and Network Visualization. GD: Graph Drawing and Network Visualization, LIPIcs, vol. 320, 3.' mla: Cultrera di Montesano, Sebastiano, et al. “The Euclidean MST-Ratio for Bi-Colored Lattices.” 32nd International Symposium on Graph Drawing and Network Visualization, vol. 320, 3, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2024, doi:10.4230/LIPIcs.GD.2024.3. short: S. Cultrera di Montesano, O. Draganov, H. Edelsbrunner, M. Saghafian, in:, 32nd International Symposium on Graph Drawing and Network Visualization, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2024. conference: end_date: 2024-09-20 location: Vienna, Austria name: 'GD: Graph Drawing and Network Visualization' start_date: 2024-09-18 corr_author: '1' date_created: 2024-11-17T23:01:47Z date_published: 2024-10-28T00:00:00Z date_updated: 2025-12-02T13:50:50Z day: '28' ddc: - '510' department: - _id: HeEd doi: 10.4230/LIPIcs.GD.2024.3 ec_funded: 1 external_id: arxiv: - '2403.10204' isi: - '001540278400001' file: - access_level: open_access checksum: 5f9b35e115c3d375e99be78da9054cb4 content_type: application/pdf creator: dernst date_created: 2024-11-18T07:49:25Z date_updated: 2024-11-18T07:49:25Z file_id: '18560' file_name: 2024_LIPIcs_CultreradiMontesano.pdf file_size: 908541 relation: main_file success: 1 file_date_updated: 2024-11-18T07:49:25Z has_accepted_license: '1' intvolume: ' 320' isi: 1 language: - iso: eng month: '10' oa: 1 oa_version: Published Version project: - _id: 266A2E9E-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '788183' name: Alpha Shape Theory Extended - _id: 268116B8-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: Z00342 name: Mathematics, Computer Science - _id: 2561EBF4-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: I02979-N35 name: Persistence and stability of geometric complexes publication: 32nd International Symposium on Graph Drawing and Network Visualization publication_identifier: isbn: - '9783959773430' issn: - 1868-8969 publication_status: published publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik quality_controlled: '1' scopus_import: '1' status: public title: The Euclidean MST-ratio for bi-colored lattices tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 320 year: '2024' ... --- OA_place: repository OA_type: green _id: '18559' abstract: - lang: eng text: We prove a 1973 conjecture due to Erdős on the existence of Steiner triple systems with arbitrarily high girth. acknowledgement: Sah and Sawhney were supported by NSF Graduate Research Fellowship Program DGE1745302. Sah was supported by the PD Soros Fellowship. Simkin was supported by the Center of Mathematical Sciences and Applications at Harvard University. article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Matthew Alan full_name: Kwan, Matthew Alan id: 5fca0887-a1db-11eb-95d1-ca9d5e0453b3 last_name: Kwan orcid: 0000-0002-4003-7567 - first_name: Ashwin full_name: Sah, Ashwin last_name: Sah - first_name: Mehtaab full_name: Sawhney, Mehtaab last_name: Sawhney - first_name: Michael full_name: Simkin, Michael last_name: Simkin citation: ama: Kwan MA, Sah A, Sawhney M, Simkin M. High-girth Steiner triple systems. Annals of Mathematics. 2024;200(3):1059-1156. doi:10.4007/annals.2024.200.3.4 apa: Kwan, M. A., Sah, A., Sawhney, M., & Simkin, M. (2024). High-girth Steiner triple systems. Annals of Mathematics. Princeton University. https://doi.org/10.4007/annals.2024.200.3.4 chicago: Kwan, Matthew Alan, Ashwin Sah, Mehtaab Sawhney, and Michael Simkin. “High-Girth Steiner Triple Systems.” Annals of Mathematics. Princeton University, 2024. https://doi.org/10.4007/annals.2024.200.3.4. ieee: M. A. Kwan, A. Sah, M. Sawhney, and M. Simkin, “High-girth Steiner triple systems,” Annals of Mathematics, vol. 200, no. 3. Princeton University, pp. 1059–1156, 2024. ista: Kwan MA, Sah A, Sawhney M, Simkin M. 2024. High-girth Steiner triple systems. Annals of Mathematics. 200(3), 1059–1156. mla: Kwan, Matthew Alan, et al. “High-Girth Steiner Triple Systems.” Annals of Mathematics, vol. 200, no. 3, Princeton University, 2024, pp. 1059–156, doi:10.4007/annals.2024.200.3.4. short: M.A. Kwan, A. Sah, M. Sawhney, M. Simkin, Annals of Mathematics 200 (2024) 1059–1156. corr_author: '1' date_created: 2024-11-17T23:01:48Z date_published: 2024-11-01T00:00:00Z date_updated: 2025-09-08T14:40:55Z day: '01' department: - _id: MaKw doi: 10.4007/annals.2024.200.3.4 external_id: arxiv: - '2201.04554' isi: - '001366233800004' intvolume: ' 200' isi: 1 issue: '3' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2201.04554 month: '11' oa: 1 oa_version: Preprint page: 1059-1156 publication: Annals of Mathematics publication_identifier: eissn: - 1939-8980 issn: - 0003-486X publication_status: published publisher: Princeton University quality_controlled: '1' scopus_import: '1' status: public title: High-girth Steiner triple systems type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 200 year: '2024' ... --- OA_type: closed access _id: '18563' abstract: - lang: eng text: I give a personal account about the wave of new research activities that rose in the 1990s on the specification, verification, and control of real-time systems. acknowledgement: I thank all my collaborators over the years. None of the mentioned contributions would have been possible without them. I also apologize for all omissions. The selection of contributions in this essay reflects primarily my personal involvement rather than any measure of importance. alternative_title: - LNCS article_processing_charge: No author: - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000-0002-2985-7724 citation: ama: 'Henzinger TA. Reminiscences of a Real-Time Researcher. In: Graf S, Pettersson P, Steffen B, eds. Real Time and Such. Vol 15230. LNCS. Cham: Springer Nature; 2024:154-164. doi:10.1007/978-3-031-73751-0_12' apa: 'Henzinger, T. A. (2024). Reminiscences of a Real-Time Researcher. In S. Graf, P. Pettersson, & B. Steffen (Eds.), Real Time and Such (Vol. 15230, pp. 154–164). Cham: Springer Nature. https://doi.org/10.1007/978-3-031-73751-0_12' chicago: 'Henzinger, Thomas A. “Reminiscences of a Real-Time Researcher.” In Real Time and Such, edited by Susanne Graf, Paul Pettersson, and Bernhard Steffen, 15230:154–64. LNCS. Cham: Springer Nature, 2024. https://doi.org/10.1007/978-3-031-73751-0_12.' ieee: 'T. A. Henzinger, “Reminiscences of a Real-Time Researcher,” in Real Time and Such, vol. 15230, S. Graf, P. Pettersson, and B. Steffen, Eds. Cham: Springer Nature, 2024, pp. 154–164.' ista: 'Henzinger TA. 2024.Reminiscences of a Real-Time Researcher. In: Real Time and Such. LNCS, vol. 15230, 154–164.' mla: Henzinger, Thomas A. “Reminiscences of a Real-Time Researcher.” Real Time and Such, edited by Susanne Graf et al., vol. 15230, Springer Nature, 2024, pp. 154–64, doi:10.1007/978-3-031-73751-0_12. short: T.A. Henzinger, in:, S. Graf, P. Pettersson, B. Steffen (Eds.), Real Time and Such, Springer Nature, Cham, 2024, pp. 154–164. corr_author: '1' date_created: 2024-11-18T09:10:06Z date_published: 2024-10-23T00:00:00Z date_updated: 2025-08-05T12:19:50Z day: '23' department: - _id: ToHe doi: 10.1007/978-3-031-73751-0_12 editor: - first_name: Susanne full_name: Graf, Susanne last_name: Graf - first_name: Paul full_name: Pettersson, Paul last_name: Pettersson - first_name: Bernhard full_name: Steffen, Bernhard last_name: Steffen intvolume: ' 15230' language: - iso: eng month: '10' oa_version: None page: 154-164 place: Cham publication: Real Time and Such publication_identifier: eisbn: - '9783031737510' eissn: - 1611-3349 isbn: - '9783031737503' issn: - 0302-9743 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' series_title: LNCS status: public title: Reminiscences of a Real-Time Researcher type: book_chapter user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 15230 year: '2024' ... --- OA_place: publisher _id: '18568' abstract: - lang: eng text: "Locomotion is ubiquitous in the animal kingdom because an animal's survival depends on its ability to navigate its environment to find food, avoid predators and locate potential mates. These behaviours require control mechanisms that can extract information from the environment, particularly visual cues. Selective evolutionary pressures have thus refined such visuomotor transformations in a species-specific manner to meet the specific ecological and ethological challenges of each organism. However, a common challenge across organisms as visual information processing\r\nbecomes increasingly detailed is the mechanisms required to synthesise disparate pieces of information into a coherent percept or unified picture of the world. In this thesis, I investigate how disparate visual information is combined in the brain of Drosophila melanogaster to effectively guide locomotion.\r\nFor this, I first designed and built a behavioural setup to record locomotion and present visual stimuli to freely-walking fruit flies in a closed-loop manner. This setup allowed the investigation of innate visually-guided behaviours, including the optomotor reflex and courtship.\r\nSecond, taking advantage of my system I investigated the optomotor response, a reflexive visual stabilisation behaviour in which flies turn in the direction of global motion to minimise retinal slip. This behaviour is thought to be mediated by Lobula plate tangential cells (LPTCs); a complex network of optic-flow-sensitive neurons essential for self-motion estimation. Using a novel genetic mutant, I demonstrate that electrical coupling between two LPTC subtypes, contralateral HS and H2 neurons, regulates the balance between smooth optomotor turning and saccadic anti-optomotor responses. These findings underscore the critical role of binocular motion cue integration in guiding course control. Finally, I developed a novel behavioural paradigm in which a sexually aroused male fruit fly is presented with an optomotor distractor. This setup creates competition between two visual behaviours, courtship tracking and the optomotor response, enabling me to explore how the visual system resolves this conflict. In this setting, males\r\nengaged in courtship selectively suppress their optomotor response based on the female's location. Furthermore, when this experiment is replicated with an “artificial female”, optogenetically aroused males alternate between tracking and optomotor responses. The probability and dynamics of this switching are determined by the relative strengths of the two competing stimuli. In summary, the results presented in this thesis explore two mechanisms – integration and competition - through which visual information is combined in the brain of the fruit fly to drive locomotion." acknowledged_ssus: - _id: M-Shop acknowledgement: I am incredibly thankful for the outstanding support provided by ISTA, especially the Machine Shop team, who made conducting research much easier and more efficient. I am also grateful for the funding provided by European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie programme (665385) and The German Research Foundation grant DFG (SPP2205) “Evolutionary optimization of neuronal processing”. alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Roshan K full_name: Satapathy, Roshan K id: 46046B7A-F248-11E8-B48F-1D18A9856A87 last_name: Satapathy orcid: 0009-0006-2974-5075 citation: ama: Satapathy RK. Mechanisms of visual integration and competition in innate behaviours in Drosophila melanogaster. 2024. doi:10.15479/at:ista:18568 apa: Satapathy, R. K. (2024). Mechanisms of visual integration and competition in innate behaviours in Drosophila melanogaster. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:18568 chicago: Satapathy, Roshan K. “Mechanisms of Visual Integration and Competition in Innate Behaviours in Drosophila Melanogaster.” Institute of Science and Technology Austria, 2024. https://doi.org/10.15479/at:ista:18568. ieee: R. K. Satapathy, “Mechanisms of visual integration and competition in innate behaviours in Drosophila melanogaster,” Institute of Science and Technology Austria, 2024. ista: Satapathy RK. 2024. Mechanisms of visual integration and competition in innate behaviours in Drosophila melanogaster. Institute of Science and Technology Austria. mla: Satapathy, Roshan K. Mechanisms of Visual Integration and Competition in Innate Behaviours in Drosophila Melanogaster. Institute of Science and Technology Austria, 2024, doi:10.15479/at:ista:18568. short: R.K. Satapathy, Mechanisms of Visual Integration and Competition in Innate Behaviours in Drosophila Melanogaster, Institute of Science and Technology Austria, 2024. corr_author: '1' date_created: 2024-11-19T12:34:30Z date_published: 2024-11-20T00:00:00Z date_updated: 2026-04-07T13:00:36Z day: '20' ddc: - '573' degree_awarded: PhD department: - _id: GradSch - _id: MaJö doi: 10.15479/at:ista:18568 ec_funded: 1 file: - access_level: open_access checksum: 340f2bfe882c8a85e11ec0687ca15f5e content_type: application/pdf creator: rsatapat date_created: 2024-11-19T12:39:55Z date_updated: 2024-11-19T12:39:55Z file_id: '18570' file_name: Roshan PhD thesis-Final.pdf file_size: 10960975 relation: main_file success: 1 - access_level: closed checksum: 0f846fce60d6ea511e07f77eff59a6a1 content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: rsatapat date_created: 2024-11-19T12:46:47Z date_updated: 2024-12-13T10:27:25Z file_id: '18571' file_name: Roshan PhD thesis-Final.docx file_size: 36695917 relation: source_file file_date_updated: 2024-12-13T10:27:25Z has_accepted_license: '1' language: - iso: eng license: https://creativecommons.org/licenses/by-sa/4.0/ month: '11' oa: 1 oa_version: Published Version page: '114' project: - _id: 2564DBCA-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '665385' name: International IST Doctoral Program publication_identifier: isbn: - 978-3-99078-047-3 issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '18444' relation: part_of_dissertation status: public status: public supervisor: - first_name: Maximilian A full_name: Jösch, Maximilian A id: 2BD278E6-F248-11E8-B48F-1D18A9856A87 last_name: Jösch orcid: 0000-0002-3937-1330 title: Mechanisms of visual integration and competition in innate behaviours in Drosophila melanogaster tmp: image: /images/cc_by_sa.png legal_code_url: https://creativecommons.org/licenses/by-sa/4.0/legalcode name: Creative Commons Attribution-ShareAlike 4.0 International Public License (CC BY-SA 4.0) short: CC BY-SA (4.0) type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2024' ... --- OA_place: publisher _id: '18579' abstract: - lang: eng text: 'Electrophysiological, calcium two-photon recordings and behavioral data for Vega-Zuniga et al. Relevant information can be found in the ''README.txt'' files. ' acknowledged_ssus: - _id: ScienComp - _id: PreCl - _id: M-Shop - _id: Bio - _id: LifeSc acknowledgement: Freyja Lange, Michael Schunn, and Todor Asenov article_processing_charge: No author: - first_name: Tomas A full_name: Vega Zuniga, Tomas A id: 2E7C4E78-F248-11E8-B48F-1D18A9856A87 last_name: Vega Zuniga - first_name: Anton L full_name: Sumser, Anton L id: 3320A096-F248-11E8-B48F-1D18A9856A87 last_name: Sumser orcid: 0000-0002-4792-1881 - first_name: Olga full_name: Symonova, Olga id: 3C0C7BC6-F248-11E8-B48F-1D18A9856A87 last_name: Symonova orcid: 0000-0003-2012-9947 - first_name: Peter full_name: Koppensteiner, Peter id: 3B8B25A8-F248-11E8-B48F-1D18A9856A87 last_name: Koppensteiner orcid: 0000-0002-3509-1948 - first_name: Florian full_name: Schmidt, Florian id: A2EF226A-AF19-11E9-924C-0525E6697425 last_name: Schmidt - first_name: Maximilian A full_name: Jösch, Maximilian A id: 2BD278E6-F248-11E8-B48F-1D18A9856A87 last_name: Jösch orcid: 0000-0002-3937-1330 citation: ama: Vega Zuniga TA, Sumser AL, Symonova O, Koppensteiner P, Schmidt F, Jösch MA. A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics. 2024. doi:10.15479/AT:ISTA:18579 apa: Vega Zuniga, T. A., Sumser, A. L., Symonova, O., Koppensteiner, P., Schmidt, F., & Jösch, M. A. (2024). A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:18579 chicago: Vega Zuniga, Tomas A, Anton L Sumser, Olga Symonova, Peter Koppensteiner, Florian Schmidt, and Maximilian A Jösch. “A Thalamic Hub-and-Spoke Network Enables Visual Perception during Action by Coordinating Visuomotor Dynamics.” Institute of Science and Technology Austria, 2024. https://doi.org/10.15479/AT:ISTA:18579. ieee: T. A. Vega Zuniga, A. L. Sumser, O. Symonova, P. Koppensteiner, F. Schmidt, and M. A. Jösch, “A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics.” Institute of Science and Technology Austria, 2024. ista: Vega Zuniga TA, Sumser AL, Symonova O, Koppensteiner P, Schmidt F, Jösch MA. 2024. A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics, Institute of Science and Technology Austria, 10.15479/AT:ISTA:18579. mla: Vega Zuniga, Tomas A., et al. A Thalamic Hub-and-Spoke Network Enables Visual Perception during Action by Coordinating Visuomotor Dynamics. Institute of Science and Technology Austria, 2024, doi:10.15479/AT:ISTA:18579. short: T.A. Vega Zuniga, A.L. Sumser, O. Symonova, P. Koppensteiner, F. Schmidt, M.A. Jösch, (2024). corr_author: '1' date_created: 2024-11-22T13:48:12Z date_published: 2024-12-09T00:00:00Z date_updated: 2026-06-18T18:12:08Z day: '09' ddc: - '570' department: - _id: MaJö doi: 10.15479/AT:ISTA:18579 ec_funded: 1 file: - access_level: open_access checksum: 8b13990ca1a458ae3f3ae54c2e888564 content_type: application/x-zip-compressed creator: symonova date_created: 2024-12-06T13:28:18Z date_updated: 2024-12-09T10:24:25Z file_id: '18625' file_name: electro_physiology_data.zip file_size: 800647957 relation: main_file - access_level: open_access checksum: c5a4d71c5f29c009c3d96a3244532afa content_type: application/x-zip-compressed creator: symonova date_created: 2024-12-09T10:21:10Z date_updated: 2024-12-09T10:21:10Z file_id: '18636' file_name: NN_vLGN_Ca_data.zip file_size: 828410832 relation: main_file success: 1 - access_level: open_access checksum: 63651df0186196969553dc48b467f6ab content_type: text/plain creator: symonova date_created: 2024-12-09T12:54:55Z date_updated: 2024-12-09T12:54:55Z file_id: '18637' file_name: readme.txt file_size: 505 relation: main_file success: 1 file_date_updated: 2024-12-09T12:54:55Z has_accepted_license: '1' month: '12' oa: 1 oa_version: Published Version project: - _id: 264FEA02-B435-11E9-9278-68D0E5697425 grant_number: ALTF 1098-2017 name: Connecting sensory with motor processing in the superior colliculus - _id: 266D407A-B435-11E9-9278-68D0E5697425 grant_number: LT000256 name: Neuronal networks of salience and spatial detection in the murine superior colliculus - _id: 2634E9D2-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '756502' name: Circuits of Visual Attention - _id: bdaf81a8-d553-11ed-ba76-c95961984540 grant_number: '101086580' name: 'Action Selection in the Midbrain: Neuromodulation of Visuomotor Senses' publisher: Institute of Science and Technology Austria related_material: record: - id: '19076' relation: used_in_publication status: public status: public title: A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: research_data user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2024' ...