---
OA_place: publisher
OA_type: hybrid
_id: '21759'
abstract:
- lang: eng
text: 'Promoters and enhancers are cis-regulatory elements (CREs), DNA sequences
that bind transcription factor (TF) proteins to up- or down-regulate target genes.
Decades-long efforts yielded TF-DNA interaction models that predict how strongly
an individual TF binds arbitrary DNA sequences and how individual binding events
on the CRE combine to affect gene expression. These insights can be synthesized
into a global, biophysically realistic, and quantitative genotype-phenotype (GP)
map for gene regulation, a ‘holy grail’ for the application of evolutionary theory.
A global map provides a rare opportunity to simulate the long-term evolution of
regulatory sequences and pose several fundamental questions: How long does it
take to evolve CREs de novo? How many non-trivial regulatory functions exist in
sequence space? How connected are they? For which regulatory architecture is CRE
evolution most rapid and evolvable? In this article, the second of a two-part
series, we review the application of evolutionary concepts — epistasis, robustness,
evolvability, tunability, plasticity, and bet-hedging — to the evolution of gene
regulatory sequences. We then evaluate the potential for a unifying theory for
the evolution of regulatory sequences and identify key open challenges.'
acknowledgement: "We thank Calin Guet and Santiago Herrera-Álvarez for essential contributions
to this manuscript.\r\nE.M. acknowledges support from the APART-USA fellowship,
jointly funded by the Austrian Academy of Sciences (ÖAW) and the Institute of Science
and Technology Austria (ISTA). N.B. acknowledges funding from the ERC Advanced Grant
101055327 “HaplotypeStructure”.\r\nThis study was also supported by the European
Molecular Biology Laboratory (N.O.B., J.C.)."
article_number: '102472'
article_processing_charge: Yes (via OA deal)
article_type: review
author:
- first_name: Elia
full_name: Mascolo, Elia
id: 776a6ed0-a053-11f0-8635-80b95e0e0d53
last_name: Mascolo
orcid: 0000-0003-2977-7844
- first_name: Reka E
full_name: Körei, Reka E
id: 50FDE43E-AA30-11E9-A72B-8A12E6697425
last_name: Körei
- first_name: Noa O.
full_name: Borst, Noa O.
last_name: Borst
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Justin
full_name: Crocker, Justin
last_name: Crocker
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
citation:
ama: 'Mascolo E, Körei RE, Borst NO, Barton NH, Crocker J, Tkačik G. Long-term evolution
of regulatory DNA sequences. Part 2: Theory and future challenges. Current
Opinion in Genetics and Development. 2026;98. doi:10.1016/j.gde.2026.102472'
apa: 'Mascolo, E., Körei, R. E., Borst, N. O., Barton, N. H., Crocker, J., &
Tkačik, G. (2026). Long-term evolution of regulatory DNA sequences. Part 2: Theory
and future challenges. Current Opinion in Genetics and Development. Elsevier.
https://doi.org/10.1016/j.gde.2026.102472'
chicago: 'Mascolo, Elia, Reka E Körei, Noa O. Borst, Nicholas H Barton, Justin Crocker,
and Gašper Tkačik. “Long-Term Evolution of Regulatory DNA Sequences. Part 2: Theory
and Future Challenges.” Current Opinion in Genetics and Development. Elsevier,
2026. https://doi.org/10.1016/j.gde.2026.102472.'
ieee: 'E. Mascolo, R. E. Körei, N. O. Borst, N. H. Barton, J. Crocker, and G. Tkačik,
“Long-term evolution of regulatory DNA sequences. Part 2: Theory and future challenges,”
Current Opinion in Genetics and Development, vol. 98. Elsevier, 2026.'
ista: 'Mascolo E, Körei RE, Borst NO, Barton NH, Crocker J, Tkačik G. 2026. Long-term
evolution of regulatory DNA sequences. Part 2: Theory and future challenges. Current
Opinion in Genetics and Development. 98, 102472.'
mla: 'Mascolo, Elia, et al. “Long-Term Evolution of Regulatory DNA Sequences. Part
2: Theory and Future Challenges.” Current Opinion in Genetics and Development,
vol. 98, 102472, Elsevier, 2026, doi:10.1016/j.gde.2026.102472.'
short: E. Mascolo, R.E. Körei, N.O. Borst, N.H. Barton, J. Crocker, G. Tkačik, Current
Opinion in Genetics and Development 98 (2026).
corr_author: '1'
date_created: 2026-04-26T22:01:46Z
date_published: 2026-04-15T00:00:00Z
date_updated: 2026-04-28T12:41:00Z
day: '15'
department:
- _id: GaTk
- _id: NiBa
doi: 10.1016/j.gde.2026.102472
intvolume: ' 98'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.gde.2026.102472
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: bd6958e0-d553-11ed-ba76-86eba6a76c00
grant_number: '101055327'
name: Understanding the evolution of continuous genomes
publication: Current Opinion in Genetics and Development
publication_identifier:
eissn:
- 1879-0380
issn:
- 0959-437X
publication_status: epub_ahead
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Long-term evolution of regulatory DNA sequences. Part 2: Theory and future
challenges'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 98
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21766'
abstract:
- lang: eng
text: We provide a new characterisation of the decades old open problem of extending
bilipschitz mappings given on a Euclidean separated net. In particular, this allows
for the complete positive solution of the open problem in dimension two. Along
the way, we develop a set of tools for bilipschitz extensions of mappings between
subsets of Euclidean spaces.
acknowledgement: "The present work developed from a research visit of M.D. to V.K.
at IST Austria, funded by\r\na London Mathematical Society Research in Pairs grant.
This work was done while V.K. was fully funded by the Austria Science Fund (FWF)
[M 3100-N]."
article_processing_charge: Yes (in subscription journal)
article_type: original
arxiv: 1
author:
- first_name: Michael
full_name: Dymond, Michael
last_name: Dymond
- first_name: Vojtech
full_name: Kaluza, Vojtech
id: 21AE5134-9EAC-11EA-BEA2-D7BD3DDC885E
last_name: Kaluza
orcid: 0000-0002-2512-8698
citation:
ama: Dymond M, Kaluza V. Extending bilipschitz mappings between separated nets.
Annales Fennici Mathematici. 2026;51(1):237-260. doi:10.54330/afm.181562
apa: Dymond, M., & Kaluza, V. (2026). Extending bilipschitz mappings between
separated nets. Annales Fennici Mathematici. Finnish Mathematical Society.
https://doi.org/10.54330/afm.181562
chicago: Dymond, Michael, and Vojtech Kaluza. “Extending Bilipschitz Mappings between
Separated Nets.” Annales Fennici Mathematici. Finnish Mathematical Society,
2026. https://doi.org/10.54330/afm.181562.
ieee: M. Dymond and V. Kaluza, “Extending bilipschitz mappings between separated
nets,” Annales Fennici Mathematici, vol. 51, no. 1. Finnish Mathematical
Society, pp. 237–260, 2026.
ista: Dymond M, Kaluza V. 2026. Extending bilipschitz mappings between separated
nets. Annales Fennici Mathematici. 51(1), 237–260.
mla: Dymond, Michael, and Vojtech Kaluza. “Extending Bilipschitz Mappings between
Separated Nets.” Annales Fennici Mathematici, vol. 51, no. 1, Finnish Mathematical
Society, 2026, pp. 237–60, doi:10.54330/afm.181562.
short: M. Dymond, V. Kaluza, Annales Fennici Mathematici 51 (2026) 237–260.
corr_author: '1'
date_created: 2026-04-26T22:01:47Z
date_published: 2026-04-17T00:00:00Z
date_updated: 2026-04-28T12:06:00Z
day: '17'
ddc:
- '510'
department:
- _id: UlWa
doi: 10.54330/afm.181562
external_id:
arxiv:
- '2507.22007'
file:
- access_level: open_access
checksum: 442023926a3803d5d6ca8db8dbc4af1c
content_type: application/pdf
creator: dernst
date_created: 2026-04-28T12:03:13Z
date_updated: 2026-04-28T12:03:13Z
file_id: '21772'
file_name: 2026_AnnalesFenniciMath_Dymond.pdf
file_size: 342082
relation: main_file
success: 1
file_date_updated: 2026-04-28T12:03:13Z
has_accepted_license: '1'
intvolume: ' 51'
issue: '1'
keyword:
- Lipschitz
- bilipschitz
- extension
- separated net.
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 237-260
project:
- _id: fc35eaa2-9c52-11eb-aca3-88501ab155e9
grant_number: M03100
name: Spectra and topology of graphs and of simplicial complexes
publication: Annales Fennici Mathematici
publication_identifier:
eissn:
- 2737-114X
issn:
- 2737-0690
publication_status: published
publisher: Finnish Mathematical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Extending bilipschitz mappings between separated nets
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 51
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21006'
abstract:
- lang: eng
text: Modern experimental methods in programmable self-assembly make it possible
to precisely design particle concentrations, shapes and interactions. However,
more physical insight is needed before we can take full advantage of this vast
design space to assemble nanostructures with complex form and function. Here we
show how a substantial part of this design space can be quickly and comprehensively
understood by identifying a class of thermodynamic constraints that act on it.
These thermodynamic constraints form a high-dimensional convex polyhedron that
determines which nanostructures can be assembled at high equilibrium yield and
reveals limitations that govern the coexistence of structures. We validate our
predictions through detailed, quantitative assembly experiments of nanoscale particles
synthesized using DNA origami. Our results uncover physical relationships underpinning
many-component programmable self-assembly in equilibrium and form the basis for
robust inverse design, applicable to various systems from biological protein complexes
to synthetic nanomachines.
acknowledgement: We thank B. Isaac and A. Tiano for their technical support with the
electron microscopy and S. Waitukaitis for helpful comments on the manuscript. The
TEM images were prepared and imaged at the Brandeis Electron Microscopy facility.
This work was supported by the Gesellschaft für Forschungsförderung Niederösterreich
under project FTI23-G-011 (M.C.H. and C.P.G.), the Brandeis University Materials
Research Science and Engineering Center (MRSEC) under grant number NSF DMR-2011846
(T.E.V., D.H. and W.B.R.) and the Smith Family Foundation (W.B.R.). Open access
funding provided by Institute of Science and Technology (IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Maximilian
full_name: Hübl, Maximilian
id: 5eb8629e-15b2-11ec-abd3-e6f3e5e01f32
last_name: Hübl
- first_name: Thomas E.
full_name: Videbæk, Thomas E.
last_name: Videbæk
- first_name: Daichi
full_name: Hayakawa, Daichi
last_name: Hayakawa
- first_name: W. Benjamin
full_name: Rogers, W. Benjamin
last_name: Rogers
- first_name: Carl Peter
full_name: Goodrich, Carl Peter
id: EB352CD2-F68A-11E9-89C5-A432E6697425
last_name: Goodrich
orcid: 0000-0002-1307-5074
citation:
ama: Hübl M, Videbæk TE, Hayakawa D, Rogers WB, Goodrich CP. A polyhedral structure
controls programmable self-assembly. Nature Physics. 2026. doi:10.1038/s41567-025-03120-3
apa: Hübl, M., Videbæk, T. E., Hayakawa, D., Rogers, W. B., & Goodrich, C. P.
(2026). A polyhedral structure controls programmable self-assembly. Nature
Physics. Springer Nature. https://doi.org/10.1038/s41567-025-03120-3
chicago: Hübl, Maximilian, Thomas E. Videbæk, Daichi Hayakawa, W. Benjamin Rogers,
and Carl Peter Goodrich. “A Polyhedral Structure Controls Programmable Self-Assembly.”
Nature Physics. Springer Nature, 2026. https://doi.org/10.1038/s41567-025-03120-3.
ieee: M. Hübl, T. E. Videbæk, D. Hayakawa, W. B. Rogers, and C. P. Goodrich, “A
polyhedral structure controls programmable self-assembly,” Nature Physics.
Springer Nature, 2026.
ista: Hübl M, Videbæk TE, Hayakawa D, Rogers WB, Goodrich CP. 2026. A polyhedral
structure controls programmable self-assembly. Nature Physics.
mla: Hübl, Maximilian, et al. “A Polyhedral Structure Controls Programmable Self-Assembly.”
Nature Physics, Springer Nature, 2026, doi:10.1038/s41567-025-03120-3.
short: M. Hübl, T.E. Videbæk, D. Hayakawa, W.B. Rogers, C.P. Goodrich, Nature Physics
(2026).
corr_author: '1'
date_created: 2026-01-20T10:02:19Z
date_published: 2026-01-08T00:00:00Z
date_updated: 2026-04-28T11:56:45Z
day: '08'
ddc:
- '570'
- '540'
department:
- _id: CaGo
- _id: GradSch
doi: 10.1038/s41567-025-03120-3
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41567-025-03120-3
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 8dd93da8-16d5-11f0-9cad-d2c70200d9a5
grant_number: FTI23-G-011
name: Dynamically reconfigurable self-assembly with triangular DNA-origami bricks
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/behind-natures-blueprints/
scopus_import: '1'
status: public
title: A polyhedral structure controls programmable self-assembly
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21760'
abstract:
- lang: eng
text: 3I/ATLAS is the third interstellar object discovered to date, following 1I/‘Oumuamua
and 2I/Borisov. Its unusually high excess velocity and active cometary nature
make it a key probe of the Galactic population of icy planetesimals. Understanding
its origin requires its past trajectory through the Galaxy to be traced and the
possible role of stellar encounters to be assessed, both as a potential origin
and a perturber to its orbit. We integrated the orbit of 3I/ATLAS backward in
time for 10 Myr, together with a sample of Gaia DR3 stars with high-quality astrometry
and radial velocities, to identify close passages within 2 pc. We identify 93
nominal encounters, 62 of which are significant at the 2σ level. However, none
of these encounters produced any meaningful perturbation. The strongest perturber
Gaia DR3 6863591389529611264 at 0.30 pc and with a relative velocity of 35 km
s−1, imparted only a velocity change of ∣Δv∣ ≃ 5 × 10−4 km s−1 to the orbit
of 3I/ATLAS. Our results indicate that no stellar flybys within the past 10 Myr
and 500 pc contained in Gaia DR3 can account for the present trajectory of 3I/ATLAS
or be associated with its origin. We further show that 3I/ATLAS is kinematically
consistent with a thin-disk population, despite its large peculiar velocity.
acknowledgement: We thank the anonymous referee for a careful reading of the manuscript
and for constructive comments that improved the paper. X.P.C. and S.T. thank J.L.
Gragera-Más and Ylva Götberg for their valuable feedback and comments. X.P.C. acknowledges
financial support from the Spanish National Programme for the Promotion of Talent
and its Employability grant PRE2022-104959 cofunded by the European Social Fund.
S.T. acknowledges the funding from the European Union’s Horizon 2020 research and
innovation program under the Marie Skłodowska-Curie grant agreement No. 101034413.
E.V. acknowledges support from the DISCOBOLO project funded by the Spanish Ministerio
de Ciencia, Innovación y Universidades under grant PID2021-127289NB-I00. A.J.M.
acknowledges support from the Swedish National Space Agency (Career grant 2023-00146).
X.P.C. and M.M. acknowledge support from the Spanish Ministerio de Ciencia, Innovaciòn
y Universidades under grants PID2021122842OB-C22 and PID2024-157964OB-C22; from
the Xunta de Galicia and the European Union (FEDER Galicia 2021-2027 Program) Ref.
ED431B 2024/21, ED431B 2024/02, and CITIC ED431G 2023/01. This work has made use
of data from the European Space Agency (ESA) Gaia mission and processed by the Gaia
Data Processing and Analysis Consortium (DPAC). Funding for the DPAC has been provided
by national institutions, particularly the institutions participating in the Gaia
Multilateral Agreement.
article_number: '146'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: X.
full_name: Pérez-Couto, X.
last_name: Pérez-Couto
- first_name: Santiago
full_name: Torres Rodriguez, Santiago
id: a8df4360-4328-11ee-8f1a-e502d0c83fc2
last_name: Torres Rodriguez
orcid: 0000-0002-3150-8988
- first_name: E.
full_name: Villaver, E.
last_name: Villaver
- first_name: A. J.
full_name: Mustill, A. J.
last_name: Mustill
- first_name: M.
full_name: Manteiga, M.
last_name: Manteiga
citation:
ama: 'Pérez-Couto X, Torres Rodriguez S, Villaver E, Mustill AJ, Manteiga M. 3I/ATLAS:
In search of the witnesses to its voyage. The Astrophysical Journal. 2026;1001(2).
doi:10.3847/1538-4357/ae56ff'
apa: 'Pérez-Couto, X., Torres Rodriguez, S., Villaver, E., Mustill, A. J., &
Manteiga, M. (2026). 3I/ATLAS: In search of the witnesses to its voyage. The
Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ae56ff'
chicago: 'Pérez-Couto, X., Santiago Torres Rodriguez, E. Villaver, A. J. Mustill,
and M. Manteiga. “3I/ATLAS: In Search of the Witnesses to Its Voyage.” The
Astrophysical Journal. IOP Publishing, 2026. https://doi.org/10.3847/1538-4357/ae56ff.'
ieee: 'X. Pérez-Couto, S. Torres Rodriguez, E. Villaver, A. J. Mustill, and M. Manteiga,
“3I/ATLAS: In search of the witnesses to its voyage,” The Astrophysical Journal,
vol. 1001, no. 2. IOP Publishing, 2026.'
ista: 'Pérez-Couto X, Torres Rodriguez S, Villaver E, Mustill AJ, Manteiga M. 2026.
3I/ATLAS: In search of the witnesses to its voyage. The Astrophysical Journal.
1001(2), 146.'
mla: 'Pérez-Couto, X., et al. “3I/ATLAS: In Search of the Witnesses to Its Voyage.”
The Astrophysical Journal, vol. 1001, no. 2, 146, IOP Publishing, 2026,
doi:10.3847/1538-4357/ae56ff.'
short: X. Pérez-Couto, S. Torres Rodriguez, E. Villaver, A.J. Mustill, M. Manteiga,
The Astrophysical Journal 1001 (2026).
date_created: 2026-04-26T22:01:46Z
date_published: 2026-04-20T00:00:00Z
date_updated: 2026-04-28T13:08:39Z
day: '20'
ddc:
- '520'
department:
- _id: LiBu
doi: 10.3847/1538-4357/ae56ff
ec_funded: 1
external_id:
arxiv:
- '2509.07678'
file:
- access_level: open_access
checksum: c3daf49261a9933c079854c38eec316f
content_type: application/pdf
creator: dernst
date_created: 2026-04-28T13:06:00Z
date_updated: 2026-04-28T13:06:00Z
file_id: '21773'
file_name: 2026_AstrophysicalJournal_PerezCouto.pdf
file_size: 2905627
relation: main_file
success: 1
file_date_updated: 2026-04-28T13:06:00Z
has_accepted_license: '1'
intvolume: ' 1001'
issue: '2'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: '3I/ATLAS: In search of the witnesses to its voyage'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1001
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21761'
abstract:
- lang: eng
text: Neural tube closure is a critical morphogenetic process in vertebrate development,
and failure to close cranial regions such as the hindbrain neuropore (HNP) leads
to severe congenital malformations. While mechanical forces such as actomyosin
purse-string contraction and directional cell crawling have been implicated in
driving HNP closure, how these forces organize local cell shape and motion to
produce large-scale tissue remodeling remains poorly understood. Using live and
fixed imaging of mouse embryos combined with cell-based biophysical modeling,
we show that these force-generating mechanisms are insufficient to explain the
reproducible patterns of cell elongation and nematic alignment observed at the
HNP border. Instead, we show that local anisotropic stress and cytoskeletal organization
are required to generate these patterns and promote midline cell motion. Our model
captures key features of cell shape dynamics and emergent nematic order, which
we confirm experimentally, including the alignment of actin fibers with cell shape
and enhanced midline cell speed. Comparative analysis with chick embryos, which
lack supracellular purse strings, supports a conserved link between tension generation
and cellular patterning. These findings establish a physical framework connecting
force generation, cell shape anisotropy, and tissue morphodynamics during epithelial
gap closure.
acknowledgement: S.B. acknowledges support from the National Institutes of Health
(NIH R35 GM143042) and the National Science Foundation (NSF MCB-2203601). G.L.G.
acknowledges support from the Wellcome Trust (211112/Z/18/Z), the Royal Society
(RG\R2\232082), and the Leverhulme Trust (RPG-2024-147). E.M. acknowledges support
from European Union’s Horizon 2021 Marie Sklodowska-Curie grant agreement no. 101067028.
F.P.-V. acknowledges support from the NOMIS foundation. The surface subtraction
macro is courtesy of Dr. Dale Moulding and available on GitHub (https://github.com/DaleMoulding/Fiji-Macros).
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Fernanda L
full_name: Perez Verdugo, Fernanda L
id: 4ecec223-9070-11ef-a0a9-bc76077bea8d
last_name: Perez Verdugo
- first_name: Eirini
full_name: Maniou, Eirini
last_name: Maniou
- first_name: Gabriel L.
full_name: Galea, Gabriel L.
last_name: Galea
- first_name: Shiladitya
full_name: Banerjee, Shiladitya
last_name: Banerjee
citation:
ama: Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. Mechanosensitive feedback
organizes cell shape and motion during hindbrain neuropore morphogenesis. Current
Biology. 2026;36(8):1903-1917.e5. doi:10.1016/j.cub.2026.02.068
apa: Perez Verdugo, F. L., Maniou, E., Galea, G. L., & Banerjee, S. (2026).
Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore
morphogenesis. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2026.02.068
chicago: Perez Verdugo, Fernanda L, Eirini Maniou, Gabriel L. Galea, and Shiladitya
Banerjee. “Mechanosensitive Feedback Organizes Cell Shape and Motion during Hindbrain
Neuropore Morphogenesis.” Current Biology. Elsevier, 2026. https://doi.org/10.1016/j.cub.2026.02.068.
ieee: F. L. Perez Verdugo, E. Maniou, G. L. Galea, and S. Banerjee, “Mechanosensitive
feedback organizes cell shape and motion during hindbrain neuropore morphogenesis,”
Current Biology, vol. 36, no. 8. Elsevier, p. 1903–1917.e5, 2026.
ista: Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. 2026. Mechanosensitive feedback
organizes cell shape and motion during hindbrain neuropore morphogenesis. Current
Biology. 36(8), 1903–1917.e5.
mla: Perez Verdugo, Fernanda L., et al. “Mechanosensitive Feedback Organizes Cell
Shape and Motion during Hindbrain Neuropore Morphogenesis.” Current Biology,
vol. 36, no. 8, Elsevier, 2026, p. 1903–1917.e5, doi:10.1016/j.cub.2026.02.068.
short: F.L. Perez Verdugo, E. Maniou, G.L. Galea, S. Banerjee, Current Biology 36
(2026) 1903–1917.e5.
date_created: 2026-04-26T22:01:46Z
date_published: 2026-04-20T00:00:00Z
date_updated: 2026-04-28T13:15:42Z
day: '20'
ddc:
- '570'
department:
- _id: AnSa
doi: 10.1016/j.cub.2026.02.068
external_id:
pmid:
- '41881011'
file:
- access_level: open_access
checksum: 80ae45457b4682c50c84f54de15aa9a8
content_type: application/pdf
creator: dernst
date_created: 2026-04-28T13:13:40Z
date_updated: 2026-04-28T13:13:40Z
file_id: '21774'
file_name: 2026_CurrentBiology_PerezVerdugo.pdf
file_size: 13402043
relation: main_file
success: 1
file_date_updated: 2026-04-28T13:13:40Z
has_accepted_license: '1'
intvolume: ' 36'
issue: '8'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 1903-1917.e5
pmid: 1
publication: Current Biology
publication_identifier:
eissn:
- 1879-0445
issn:
- 0960-9822
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanosensitive feedback organizes cell shape and motion during hindbrain
neuropore morphogenesis
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 36
year: '2026'
...
---
OA_type: closed access
_id: '21762'
abstract:
- lang: eng
text: Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular
organization. The plasmid-encoded ParMRC system forms actin-like filaments that
segregate low–copy number plasmids. In multicellular cyanobacteria such as Anabaena
sp., we found that a chromosomally encoded ParMR system has evolved into a cytoskeletal
system named CorMR with a function in cell shape control rather than DNA segregation.
Live-cell imaging, in vitro reconstitution, and cryo–electron microscopy revealed
that CorM formed dynamically unstable, antiparallel double-stranded filaments
that were recruited to the membrane by CorR through an amphipathic helix conserved
in multicellular cyanobacteria. CorMR filaments were regulated by MinC, which
excluded them from the poles and division plane. Comparative genomics indicated
that the repurposing of ParMR and Min systems coevolved with cyanobacterial multicellularity,
highlighting the evolutionary plasticity of cytoskeletal systems in bacteria.
acknowledged_ssus:
- _id: Bio
- _id: ScienComp
- _id: EM-Fac
- _id: LifeSc
acknowledgement: "We thank all members of the Loose lab at ISTA for helpful discussions;
M. Kojic for critical reading of the manuscript; A. Herrero (Sevilla University)
for sharing her extensive BACTH plasmid library and other plasmids, as well as cyanobacterial
strains; T. Dagan and F. Nies (both Kiel University) for sharing cyanobacterial
strains and plasmids and for valuable discussions; N. Sapay and A. Michon for providing
the Amphipaseek code, which enabled us to perform our large-scale amphipathic helix
screen of cyanobacterial CorR proteins; V.-V. Hodirnau for support in cryo-ET data
collection; and J. Hansen for advice about cryo-EM data processing.\r\nThis work
was supported by the Scientific Service Units (SSU) of ISTA through resources provided
by the Imaging & Optics Facility (IOF), the Scientific Computing (SciComp), the
Electron Microscopy Facility (EMF), and the Lab Support Facility (LSF). This work
was funded by the European Union’s Horizon 2020 research and innovation program
(Marie Skłodowska-Curie grant 101034413 to B.L.S.); the European Research Council
(ERC) of the European Union (grant ActinID 101076260 to F.K.M.S.); the Swiss National
Science Foundation (starting grant TMSGI3_226208 to G.L.W.); and the Jean-Jacques
et Letitia Lopez-Loreta Foundation (G.L.W.)."
article_number: eaea6343
article_processing_charge: No
article_type: original
author:
- first_name: Benjamin L
full_name: Springstein, Benjamin L
id: b4eb62ef-ac72-11ed-9503-ed3b4d66c083
last_name: Springstein
orcid: 0000-0002-3461-5391
- first_name: Manjunath
full_name: Javoor, Manjunath
id: 305ab18b-dc7d-11ea-9b2f-b58195228ea2
last_name: Javoor
orcid: 0000-0003-2311-2112
- first_name: Daniela
full_name: Megrian, Daniela
last_name: Megrian
- first_name: Roman
full_name: Hajdu, Roman
id: ffab949d-133f-11ed-8f02-94de21ace503
last_name: Hajdu
- first_name: Dustin M.
full_name: Hanke, Dustin M.
last_name: Hanke
- first_name: Bettina
full_name: Zens, Bettina
id: 45FD126C-F248-11E8-B48F-1D18A9856A87
last_name: Zens
orcid: 0000-0002-9561-1239
- first_name: Gregor L.
full_name: Weiss, Gregor L.
last_name: Weiss
- first_name: Florian Km
full_name: Schur, Florian Km
id: 48AD8942-F248-11E8-B48F-1D18A9856A87
last_name: Schur
orcid: 0000-0003-4790-8078
- first_name: Martin
full_name: Loose, Martin
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
citation:
ama: Springstein BL, Javoor M, Megrian D, et al. Repurposing of a DNA segregation
machinery into a cytoskeletal system controlling cell shape. Science. 2026;392(6795).
doi:10.1126/science.aea6343
apa: Springstein, B. L., Javoor, M., Megrian, D., Hajdu, R., Hanke, D. M., Zens,
B., … Loose, M. (2026). Repurposing of a DNA segregation machinery into a cytoskeletal
system controlling cell shape. Science. AAAS. https://doi.org/10.1126/science.aea6343
chicago: Springstein, Benjamin L, Manjunath Javoor, Daniela Megrian, Roman Hajdu,
Dustin M. Hanke, Bettina Zens, Gregor L. Weiss, Florian KM Schur, and Martin Loose.
“Repurposing of a DNA Segregation Machinery into a Cytoskeletal System Controlling
Cell Shape.” Science. AAAS, 2026. https://doi.org/10.1126/science.aea6343.
ieee: B. L. Springstein et al., “Repurposing of a DNA segregation machinery
into a cytoskeletal system controlling cell shape,” Science, vol. 392,
no. 6795. AAAS, 2026.
ista: Springstein BL, Javoor M, Megrian D, Hajdu R, Hanke DM, Zens B, Weiss GL,
Schur FK, Loose M. 2026. Repurposing of a DNA segregation machinery into a cytoskeletal
system controlling cell shape. Science. 392(6795), eaea6343.
mla: Springstein, Benjamin L., et al. “Repurposing of a DNA Segregation Machinery
into a Cytoskeletal System Controlling Cell Shape.” Science, vol. 392,
no. 6795, eaea6343, AAAS, 2026, doi:10.1126/science.aea6343.
short: B.L. Springstein, M. Javoor, D. Megrian, R. Hajdu, D.M. Hanke, B. Zens, G.L.
Weiss, F.K. Schur, M. Loose, Science 392 (2026).
corr_author: '1'
date_created: 2026-04-26T22:01:46Z
date_published: 2026-04-16T00:00:00Z
date_updated: 2026-04-28T13:29:05Z
day: '16'
department:
- _id: MaLo
- _id: FlSc
- _id: GradSch
- _id: EM-Fac
doi: 10.1126/science.aea6343
ec_funded: 1
external_id:
pmid:
- '41990175'
intvolume: ' 392'
issue: '6795'
language:
- iso: eng
month: '04'
oa_version: None
pmid: 1
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
- _id: bd980d18-d553-11ed-ba76-ceaa645c97eb
grant_number: '101076260'
name: A molecular atlas of Actin filament IDentities in the cell motility machinery
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: Repurposing of a DNA segregation machinery into a cytoskeletal system controlling
cell shape
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 392
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21755'
abstract:
- lang: eng
text: Tropical shallow clouds are a major source of uncertainty in Earth's climate
sensitivity, especially through their spatial arrangement, which global climate
models do not represent. Efforts to understand their organization have partly
relied on classifying observed scenes, identifying four patterns as archetypal
regimes. Here we analyze geostationary satellite imagery of the western tropical
Atlantic using the L‐function, a tool based on point pattern theory that quantifies
cloud organization across spatial scales. Classical examples of the four patterns
show distinct L‐function fingerprints, revealing their characteristic clustering
and regularity scales and aiding physical interpretation. Yet, when evaluating
many scenes at fixed spatial scales, the L‐function distribution lacks the distinct
modes expected from discrete regimes. This is corroborated by analyses of other
organization indices employing diverse approaches, from inter‐cloud nearest‐neighbor
distances to fractal analysis. Implications for the parameterization of mesoscale
cloud organization in climate models are discussed.
acknowledgement: GB was supported by an ICTP Postdoctoral Research Fellowship Agreement.
GM was supported by the CNRS. AC was supported by the European Union's Horizon 2020
research and innovation programme Marie Sklodowska-Curie Grant agreement No 101034413.
LJF acknowledges funding from the NERC Doctoral Training Partnership in Environmental
Research Grant NE/S007474/1. We thank three anonymous reviewers and Jiawei Bao for
their insightful comments, which greatly improved this manuscript.
article_number: e2025GL119921
article_processing_charge: Yes
article_type: original
author:
- first_name: Giovanni
full_name: Biagioli, Giovanni
last_name: Biagioli
- first_name: Giulio
full_name: Mandorli, Giulio
last_name: Mandorli
- first_name: Lilli Johanna
full_name: Freischem, Lilli Johanna
last_name: Freischem
- first_name: Alejandro
full_name: Casallas Garcia, Alejandro
id: 92081129-2d75-11ef-a48d-b04dd7a2385a
last_name: Casallas Garcia
orcid: 0000-0002-1988-5035
- first_name: Adrian Mark
full_name: Tompkins, Adrian Mark
last_name: Tompkins
citation:
ama: 'Biagioli G, Mandorli G, Freischem LJ, Casallas Garcia A, Tompkins AM. Spatial
patterns of shallow clouds: Challenging the concept of defined regimes. Geophysical
Research Letters. 2026;53(8). doi:10.1029/2025gl119921'
apa: 'Biagioli, G., Mandorli, G., Freischem, L. J., Casallas Garcia, A., & Tompkins,
A. M. (2026). Spatial patterns of shallow clouds: Challenging the concept of defined
regimes. Geophysical Research Letters. Wiley. https://doi.org/10.1029/2025gl119921'
chicago: 'Biagioli, Giovanni, Giulio Mandorli, Lilli Johanna Freischem, Alejandro
Casallas Garcia, and Adrian Mark Tompkins. “Spatial Patterns of Shallow Clouds:
Challenging the Concept of Defined Regimes.” Geophysical Research Letters.
Wiley, 2026. https://doi.org/10.1029/2025gl119921.'
ieee: 'G. Biagioli, G. Mandorli, L. J. Freischem, A. Casallas Garcia, and A. M.
Tompkins, “Spatial patterns of shallow clouds: Challenging the concept of defined
regimes,” Geophysical Research Letters, vol. 53, no. 8. Wiley, 2026.'
ista: 'Biagioli G, Mandorli G, Freischem LJ, Casallas Garcia A, Tompkins AM. 2026.
Spatial patterns of shallow clouds: Challenging the concept of defined regimes.
Geophysical Research Letters. 53(8), e2025GL119921.'
mla: 'Biagioli, Giovanni, et al. “Spatial Patterns of Shallow Clouds: Challenging
the Concept of Defined Regimes.” Geophysical Research Letters, vol. 53,
no. 8, e2025GL119921, Wiley, 2026, doi:10.1029/2025gl119921.'
short: G. Biagioli, G. Mandorli, L.J. Freischem, A. Casallas Garcia, A.M. Tompkins,
Geophysical Research Letters 53 (2026).
date_created: 2026-04-21T06:04:41Z
date_published: 2026-04-28T00:00:00Z
date_updated: 2026-04-28T13:35:53Z
day: '28'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1029/2025gl119921
ec_funded: 1
file:
- access_level: open_access
checksum: 2cd4ae120b14b244f5b2f50eaae0efc1
content_type: application/pdf
creator: acasalla
date_created: 2026-04-21T06:07:22Z
date_updated: 2026-04-21T06:07:22Z
file_id: '21756'
file_name: Gio_Casallas_2026.pdf
file_size: 1544417
relation: main_file
success: 1
file_date_updated: 2026-04-21T06:07:22Z
has_accepted_license: '1'
intvolume: ' 53'
issue: '8'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: Geophysical Research Letters
publication_identifier:
eissn:
- 1944-8007
issn:
- 0094-8276
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Spatial patterns of shallow clouds: Challenging the concept of defined regimes'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 53
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21752'
abstract:
- lang: eng
text: Epithelial tissues function as multicellular communities that preserve tissue
integrity while adapting to diverse environmental stresses by altering cell behaviors.
A striking manifestation of such adaptability is cell plasticity, the ability
of differentiated cells to revert to stem-like states or adopt alternative fates.
Once considered rare and confined to highly regenerative species, cell plasticity
is now recognized across the metazoan tree. In early-branching animals such as
sponges and cnidarians, transdifferentiation and dedifferentiation are integral
to life-cycle transitions and regeneration, whereas in more complex organisms,
these processes typically emerge under stress, including stem cell loss or environmental
perturbations. Here, we examine epithelial cell plasticity through evolutionary,
cellular, and molecular perspectives. Focusing on the intestinal epithelium, we
explore findings from mammalian and Drosophila models showing that progenitors
and even terminally differentiated cells can dedifferentiate in response to external
stimuli that disrupt homeostasis, such as pathogen infection and nutrient fluctuations.
We further discuss conserved mechanisms involving intercellular signaling (e.g.,
Notch, EGFR, and JAK-STAT) and chromatin states primed for reprogramming, modulated
by metabolic cues. Together, these insights position cell plasticity as an ancient
environmental adaptation strategy, shaped by conserved molecular toolkits and
refined by species- and cell lineage-specific innovations.
acknowledgement: This work was supported by JSPS/MEXT KAKENHI (grant numbers JP22J01430
to H.N., JP23H04696, JP23K24025, JP25H02543, JP25K02406 to Y.N.), JST FOREST Program
JPMJFR233E (Y.N.), The Cell Science Research Foundation (Y.N.), and Takeda Science
Foundation (Y.N.).
article_number: '103670'
article_processing_charge: Yes (in subscription journal)
article_type: review
author:
- first_name: Hiroki
full_name: Nagai, Hiroki
id: 608df3e6-e2ab-11ed-8890-c9318cec7da4
last_name: Nagai
orcid: 0000-0003-1671-9434
- first_name: Yu Ichiro
full_name: Nakajima, Yu Ichiro
last_name: Nakajima
citation:
ama: 'NAGAI H, Nakajima YI. Epithelial cell plasticity in metazoans: Evolutionary
insights into roles and mechanisms. Seminars in Cell and Developmental Biology.
2026;179-180. doi:10.1016/j.semcdb.2026.103670'
apa: 'NAGAI, H., & Nakajima, Y. I. (2026). Epithelial cell plasticity in metazoans:
Evolutionary insights into roles and mechanisms. Seminars in Cell and Developmental
Biology. Elsevier. https://doi.org/10.1016/j.semcdb.2026.103670'
chicago: 'NAGAI, HIROKI, and Yu Ichiro Nakajima. “Epithelial Cell Plasticity in
Metazoans: Evolutionary Insights into Roles and Mechanisms.” Seminars in Cell
and Developmental Biology. Elsevier, 2026. https://doi.org/10.1016/j.semcdb.2026.103670.'
ieee: 'H. NAGAI and Y. I. Nakajima, “Epithelial cell plasticity in metazoans: Evolutionary
insights into roles and mechanisms,” Seminars in Cell and Developmental Biology,
vol. 179–180. Elsevier, 2026.'
ista: 'NAGAI H, Nakajima YI. 2026. Epithelial cell plasticity in metazoans: Evolutionary
insights into roles and mechanisms. Seminars in Cell and Developmental Biology.
179–180, 103670.'
mla: 'NAGAI, HIROKI, and Yu Ichiro Nakajima. “Epithelial Cell Plasticity in Metazoans:
Evolutionary Insights into Roles and Mechanisms.” Seminars in Cell and Developmental
Biology, vol. 179–180, 103670, Elsevier, 2026, doi:10.1016/j.semcdb.2026.103670.'
short: H. NAGAI, Y.I. Nakajima, Seminars in Cell and Developmental Biology 179–180
(2026).
corr_author: '1'
date_created: 2026-04-19T22:07:49Z
date_published: 2026-05-01T00:00:00Z
date_updated: 2026-04-28T14:11:13Z
day: '01'
ddc:
- '570'
department:
- _id: XiFe
doi: 10.1016/j.semcdb.2026.103670
file:
- access_level: open_access
checksum: 0a0929a045d0cbd964297768833c14ae
content_type: application/pdf
creator: dernst
date_created: 2026-04-28T13:58:47Z
date_updated: 2026-04-28T13:58:47Z
file_id: '21775'
file_name: 2026_SeminarsCellDevBiology_Nagai.pdf
file_size: 1306613
relation: main_file
success: 1
file_date_updated: 2026-04-28T13:58:47Z
has_accepted_license: '1'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
publication: Seminars in Cell and Developmental Biology
publication_identifier:
eissn:
- 1096-3634
issn:
- 1084-9521
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Epithelial cell plasticity in metazoans: Evolutionary insights into roles
and mechanisms'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 179-180
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21705'
abstract:
- lang: eng
text: "We report the discovery of ATLAS J101342.5−451656.8 (hereafter ATLAS J1013−4516),
an 8.56 minute orbital-period mass-transferring AM Canum Venaticorum (AM CVn)
binary with a mean Gaia magnitude of G = 19.51, identified via periodic variability
in light curves from the Asteroid Terrestrial-impact Last Alert System (ATLAS)
of Gaia white dwarf candidates. Follow-up with the Large Lenslet Array Magellan
Spectrograph shows a helium-dominated accretion disk, and high-speed ULTRACAM
photometry reveals pronounced primary and secondary eclipses. We construct a decade-long
timing baseline leveraging light curves from the ATLAS and Gaia surveys, as well
as the high-speed imagers ULTRACAM on the New Energy Telescope and proto-Lightspeed
on the Magellan Clay telescope. From this timing baseline, we measure an orbital
period derivative of P 1.60 0.07 10 = ± × 12 s s−1. Interpreted in the context
of stable mass transfer, the magnitude and sign of P indicate that the orbital
evolution is governed by the interplay between gravitationalwave-driven angular-momentum
losses and mass transfer, directly probing the donor’s structural response to
mass loss. We constrain the accretor and donor mass based on stable mass-transfer
arguments assuming angularmomentum loss dominated by gravitational-wave emission,
allowing us to infer the characteristic gravitational\r\nwave strain of the binary
for future space-based GW observatories such as the Laser Interferometer Space
Antenna (LISA). We predict a characteristic strain corresponding to a 4 yr LISA
signal-to-noise ratio ≳10, establishing ATLAS J1013−4516 as a strong prospective
LISA source that will probe long-term orbital evolution in the mass-transferring
regime."
acknowledgement: This work has made use of data from the Asteroid Terrestrial-impact
Last Alert System (ATLAS) project. The Asteroid Terrestrial-impact Last Alert System
(ATLAS) project is primarily funded to search for near-Earth asteroids through NASA
grants NN12AR55G, 80NSSC18K0284, and 80NSSC18K1575; byproducts of the NEO search
include images and catalogs from the survey area. This work was partially funded
by Kepler/K2 grant J1944/80NSSC19K0112 and HST GO-15889 and STFC grants ST/T000198/1
and ST/S006109/1. The ATLAS science products have been made possible through the
contributions of the University of Hawaii Institute for Astronomy, the Queen’s University
Belfast, the Space Telescope Science Institute, the South African Astronomical Observatory,
and the Millennium Institute of Astrophysics (MAS), Chile. VSD and ULTRACAM are
supported by STFC grant ST/Z000033/1. J.G.M. gratefully acknowledges support from
the Heising-Simons Foundation and the Pappalardo family through the MIT Pappalardo
Fellowship in Physics.
article_number: '237'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Emma T.
full_name: Chickles, Emma T.
last_name: Chickles
- first_name: Joheen
full_name: Chakraborty, Joheen
last_name: Chakraborty
- first_name: Kevin B.
full_name: Burdge, Kevin B.
last_name: Burdge
- first_name: Vik S.
full_name: Dhillon, Vik S.
last_name: Dhillon
- first_name: Paul
full_name: Draghis, Paul
last_name: Draghis
- first_name: Kareem
full_name: El-Badry, Kareem
last_name: El-Badry
- first_name: Matthew J.
full_name: Green, Matthew J.
last_name: Green
- first_name: Aaron
full_name: Householder, Aaron
last_name: Householder
- first_name: Sarah
full_name: Hughes, Sarah
last_name: Hughes
- first_name: Christopher
full_name: Layden, Christopher
last_name: Layden
- first_name: Stuart P.
full_name: Littlefair, Stuart P.
last_name: Littlefair
- first_name: James
full_name: Munday, James
last_name: Munday
- first_name: Ingrid
full_name: Pelisoli, Ingrid
last_name: Pelisoli
- first_name: Maya S.
full_name: Redden, Maya S.
last_name: Redden
- first_name: John
full_name: Tonry, John
last_name: Tonry
- first_name: Joannes C
full_name: van Roestel, Joannes C
id: 4d122fc8-6083-11f0-87a5-97d68b860333
last_name: van Roestel
- first_name: Francesco Elio
full_name: Angile, Francesco Elio
last_name: Angile
- first_name: Alex J.
full_name: Brown, Alex J.
last_name: Brown
- first_name: Noel Castro
full_name: Segura, Noel Castro
last_name: Segura
- first_name: Jack
full_name: Dinsmore, Jack
last_name: Dinsmore
- first_name: Martin
full_name: Dyer, Martin
last_name: Dyer
- first_name: Gabor
full_name: Furesz, Gabor
last_name: Furesz
- first_name: Michelle
full_name: Gabutti, Michelle
last_name: Gabutti
- first_name: James
full_name: Garbutt, James
last_name: Garbutt
- first_name: Juliana
full_name: García-Mejía, Juliana
last_name: García-Mejía
- first_name: Daniel
full_name: Jarvis, Daniel
last_name: Jarvis
- first_name: Mark R.
full_name: Kennedy, Mark R.
last_name: Kennedy
- first_name: Paul
full_name: Kerry, Paul
last_name: Kerry
- first_name: James
full_name: Mccormac, James
last_name: Mccormac
- first_name: Geoffrey
full_name: Mo, Geoffrey
last_name: Mo
- first_name: Dave
full_name: Osip, Dave
last_name: Osip
- first_name: Steven
full_name: Parsons, Steven
last_name: Parsons
- first_name: Eleanor
full_name: Pike, Eleanor
last_name: Pike
- first_name: John J.
full_name: Piotrowski, John J.
last_name: Piotrowski
- first_name: Roger W.
full_name: Romani, Roger W.
last_name: Romani
- first_name: David
full_name: Sahman, David
last_name: Sahman
- first_name: Rob
full_name: Simcoe, Rob
last_name: Simcoe
citation:
ama: Chickles ET, Chakraborty J, Burdge KB, et al. An eclipsing 8.56 minutes orbital
period mass-transferring binary. The Astrophysical Journal. 2026;1000(2).
doi:10.3847/1538-4357/ae4871
apa: Chickles, E. T., Chakraborty, J., Burdge, K. B., Dhillon, V. S., Draghis, P.,
El-Badry, K., … Simcoe, R. (2026). An eclipsing 8.56 minutes orbital period mass-transferring
binary. The Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ae4871
chicago: Chickles, Emma T., Joheen Chakraborty, Kevin B. Burdge, Vik S. Dhillon,
Paul Draghis, Kareem El-Badry, Matthew J. Green, et al. “An Eclipsing 8.56 Minutes
Orbital Period Mass-Transferring Binary.” The Astrophysical Journal. IOP
Publishing, 2026. https://doi.org/10.3847/1538-4357/ae4871.
ieee: E. T. Chickles et al., “An eclipsing 8.56 minutes orbital period mass-transferring
binary,” The Astrophysical Journal, vol. 1000, no. 2. IOP Publishing, 2026.
ista: Chickles ET, Chakraborty J, Burdge KB, Dhillon VS, Draghis P, El-Badry K,
Green MJ, Householder A, Hughes S, Layden C, Littlefair SP, Munday J, Pelisoli
I, Redden MS, Tonry J, van Roestel JC, Angile FE, Brown AJ, Segura NC, Dinsmore
J, Dyer M, Furesz G, Gabutti M, Garbutt J, García-Mejía J, Jarvis D, Kennedy MR,
Kerry P, Mccormac J, Mo G, Osip D, Parsons S, Pike E, Piotrowski JJ, Romani RW,
Sahman D, Simcoe R. 2026. An eclipsing 8.56 minutes orbital period mass-transferring
binary. The Astrophysical Journal. 1000(2), 237.
mla: Chickles, Emma T., et al. “An Eclipsing 8.56 Minutes Orbital Period Mass-Transferring
Binary.” The Astrophysical Journal, vol. 1000, no. 2, 237, IOP Publishing,
2026, doi:10.3847/1538-4357/ae4871.
short: E.T. Chickles, J. Chakraborty, K.B. Burdge, V.S. Dhillon, P. Draghis, K.
El-Badry, M.J. Green, A. Householder, S. Hughes, C. Layden, S.P. Littlefair, J.
Munday, I. Pelisoli, M.S. Redden, J. Tonry, J.C. van Roestel, F.E. Angile, A.J.
Brown, N.C. Segura, J. Dinsmore, M. Dyer, G. Furesz, M. Gabutti, J. Garbutt, J.
García-Mejía, D. Jarvis, M.R. Kennedy, P. Kerry, J. Mccormac, G. Mo, D. Osip,
S. Parsons, E. Pike, J.J. Piotrowski, R.W. Romani, D. Sahman, R. Simcoe, The Astrophysical
Journal 1000 (2026).
date_created: 2026-04-12T22:01:47Z
date_published: 2026-04-01T00:00:00Z
date_updated: 2026-05-04T06:37:12Z
day: '01'
ddc:
- '520'
department:
- _id: IlCa
doi: 10.3847/1538-4357/ae4871
external_id:
arxiv:
- '2601.07925'
file:
- access_level: open_access
checksum: c8f64a78f36224d8e0ea1f324e43e389
content_type: application/pdf
creator: dernst
date_created: 2026-05-04T06:36:00Z
date_updated: 2026-05-04T06:36:00Z
file_id: '21782'
file_name: 2026_AstrophysicalJournal_Chickles.pdf
file_size: 1225916
relation: main_file
success: 1
file_date_updated: 2026-05-04T06:36:00Z
has_accepted_license: '1'
intvolume: ' 1000'
issue: '2'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: An eclipsing 8.56 minutes orbital period mass-transferring binary
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1000
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21709'
abstract:
- lang: eng
text: 'JWST’s “little red dots” (LRDs) are increasingly interpreted as active galactic
nuclei (AGN) obscured by dense thermalized gas rather than dust as evidenced by
their X-ray weakness, blackbody-like continua, and Balmer line profiles. Key questions
are how LRDs connect to standard UV-luminous AGN, whether transitional phases
exist, and whether they are observable. We present the “X-ray dot” (XRD), a compact
source at z = 3.28 observed by the NIRSpec Wide Guaranteed Time Observation survey.
The XRD exhibits LRD hallmarks: a blackbody-like (Teff ≃ 6400 K) red continuum,
a faint but blue rest-UV excess, falling mid-IR emission, and broad Balmer lines
(FWHM ∼ 2700–3200 km s−1). Unlike LRDs, however, it is remarkably X-ray luminous
(L2−10 keV = 1044.18 erg s−1) and has a continuum inflection that is blueward
of the Balmer limit. We find that the red rest-optical and blue mid-IR continuum
cannot be reproduced by standard dust-attenuated AGN models without invoking extremely
steep extinction curves, nor can the weak mid-IR emission be reconciled with well-established
X-ray–torus scaling relations. We therefore consider an alternative scenario:
the XRD may be an LRD in transition, where the gas envelope dominates the optical
continuum but optically thin sight lines allow X-rays to escape. The XRD may thus
provide a physical link between LRDs and standard AGN, offering direct evidence
that LRDs are powered by supermassive black holes and providing insight into their
accretion properties.'
acknowledgement: "We would like to thank the anonymous reviewer for their constructive
comments, which improved the final manuscript.\r\n\r\nWe thank Bernd Husemann for
his critical contributions to the NIRSpec Wide GTO survey, and in particular his
help in selecting high-priority X-ray-luminous targets.\r\n\r\nR.E.H. acknowledges
support by the German Aerospace Center (DLR) and the Federal Ministry for Economic
Affairs and Energy (BMWi) through program 50OR2403 “RUBIES.” A.d.G. acknowledges
support from a Clay Fellowship awarded by the Smithsonian Astrophysical Observatory.
A.J.B. acknowledges funding from the “FirstGalaxies” Advanced grant from the European
Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
program (grant agreement No. 789056). R.P.N. thanks Neil Pappalardo and Jane Pappalardo
for their generous support of the MIT Pappalardo Fellowships in Physics. Support
for this work was provided by the Brinson Foundation through a Brinson Prize Fellowship
grant. H.Ü. acknowledges funding by the European Union (ERC APEX, 101164796). Views
and opinions expressed are, however, those of the authors only and do not necessarily
reflect those of the European Union or the European Research Council Executive Agency.
Neither the European Union nor the granting authority can be held responsible for
them. G.V. acknowledges support from European Union’s HE ERC Starting grant No.
101040227—WINGS. B.W. acknowledges support provided by NASA through Hubble Fellowship
grant HST-HF2-51592.001 awarded by the Space Telescope Science Institute, which
is operated by the Association of Universities for Research in Astronomy, In., for
NASA, under the contract NAS 5-26555.\r\n\r\nThe data products presented herein
were retrieved from the Dawn JWST Archive (DJA). DJA is an initiative of the Cosmic
Dawn Center (DAWN).\r\n\r\nThis work is based in part on observations made with
the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski
Archive for Space Telescopes at the Space Telescope Science Institute, which is
operated by the Association of Universities for Research in Astronomy, Inc., under
NASA contract NAS 5-03127 for JWST. These observations are associated with programs
Nos. GTO-1213. The data described here may be obtained from the MAST archive at
DOI: 10.17909/qffz-b324.\r\n\r\nThis Letter employs a list of Chandra datasets,
obtained by the Chandra X-ray Observatory, contained in DOI: 10.25574/cdc.540.\r\n\r\nThis
work is based on observations taken by the 3D-HST Treasury Program (GO 12177 and
12328) with the NASA/ESA HST, which is operated by the Association of Universities
for Research in Astronomy, Inc., under NASA contract NAS5-26555.\r\n\r\nThis work
makes use of color palettes created by Martin Krzywinski designed for colorblindness.
The color palettes and more information can be found at http://mkweb.bcgsc.ca/colorblind/.\r\n\r\nFacilities:
CXO - Chandra X-ray Observatory satellite (ACIS), HST - Hubble Space Telescope satellite
(ACS, WFC3) - , CFHT - Canada-France-Hawaii Telescope (WIRCam), JWST - James Webb
Space Telescope (NIRSpec), Spitzer - Spitzer Space Telescope satellite (IRAC, MIPS)
- , JCMT - James Clerk Maxwell Telescope (SCUBA).\r\n\r\nSoftware: Astropy (Astropy
Collaboration et al. 2013, 2018, 2022), dust_attenuation, dust_extinction (K. Gordon
2024), jax (J. Bradbury et al. 2018), LaTeX (L. Lamport 1994), Matplotlib (J. D.
Hunter 2007), NumPy (T. E. Oliphant 2006; S. van der Walt et al. 2011; C. R. Harris
et al. 2020), NumPyro (D. Phan et al. 2019), scipy (P. Virtanen et al. 2020), sedpy
(B. Johnson & J. Leja 2017), specutils (Astropy-Specutils Development Team 2019),
unite (R. E. Hviding 2025)."
article_number: L18
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Raphael E.
full_name: Hviding, Raphael E.
last_name: Hviding
- first_name: Anna
full_name: De Graaff, Anna
last_name: De Graaff
- first_name: Hanpu
full_name: Liu, Hanpu
last_name: Liu
- first_name: Andy D.
full_name: Goulding, Andy D.
last_name: Goulding
- first_name: Yilun
full_name: Ma, Yilun
last_name: Ma
- first_name: Jenny E.
full_name: Greene, Jenny E.
last_name: Greene
- first_name: Leindert A.
full_name: Boogaard, Leindert A.
last_name: Boogaard
- first_name: Andrew J.
full_name: Bunker, Andrew J.
last_name: Bunker
- first_name: Nikko J.
full_name: Cleri, Nikko J.
last_name: Cleri
- first_name: Marijn
full_name: Franx, Marijn
last_name: Franx
- first_name: Michaela
full_name: Hirschmann, Michaela
last_name: Hirschmann
- first_name: Joel
full_name: Leja, Joel
last_name: Leja
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Rohan P.
full_name: Naidu, Rohan P.
last_name: Naidu
- first_name: David J.
full_name: Setton, David J.
last_name: Setton
- first_name: Hannah
full_name: Übler, Hannah
last_name: Übler
- first_name: Giacomo
full_name: Venturi, Giacomo
last_name: Venturi
- first_name: Bingjie
full_name: Wang, Bingjie
last_name: Wang
citation:
ama: 'Hviding RE, De Graaff A, Liu H, et al. The X-ray dot: Exotic dust or a late-stage
Little Red Dot? The Astrophysical Journal Letters. 2026;1000(1). doi:10.3847/2041-8213/ae4c88'
apa: 'Hviding, R. E., De Graaff, A., Liu, H., Goulding, A. D., Ma, Y., Greene, J.
E., … Wang, B. (2026). The X-ray dot: Exotic dust or a late-stage Little Red Dot?
The Astrophysical Journal Letters. IOP Publishing. https://doi.org/10.3847/2041-8213/ae4c88'
chicago: 'Hviding, Raphael E., Anna De Graaff, Hanpu Liu, Andy D. Goulding, Yilun
Ma, Jenny E. Greene, Leindert A. Boogaard, et al. “The X-Ray Dot: Exotic Dust
or a Late-Stage Little Red Dot?” The Astrophysical Journal Letters. IOP
Publishing, 2026. https://doi.org/10.3847/2041-8213/ae4c88.'
ieee: 'R. E. Hviding et al., “The X-ray dot: Exotic dust or a late-stage
Little Red Dot?,” The Astrophysical Journal Letters, vol. 1000, no. 1.
IOP Publishing, 2026.'
ista: 'Hviding RE, De Graaff A, Liu H, Goulding AD, Ma Y, Greene JE, Boogaard LA,
Bunker AJ, Cleri NJ, Franx M, Hirschmann M, Leja J, Matthee JJ, Naidu RP, Setton
DJ, Übler H, Venturi G, Wang B. 2026. The X-ray dot: Exotic dust or a late-stage
Little Red Dot? The Astrophysical Journal Letters. 1000(1), L18.'
mla: 'Hviding, Raphael E., et al. “The X-Ray Dot: Exotic Dust or a Late-Stage Little
Red Dot?” The Astrophysical Journal Letters, vol. 1000, no. 1, L18, IOP
Publishing, 2026, doi:10.3847/2041-8213/ae4c88.'
short: R.E. Hviding, A. De Graaff, H. Liu, A.D. Goulding, Y. Ma, J.E. Greene, L.A.
Boogaard, A.J. Bunker, N.J. Cleri, M. Franx, M. Hirschmann, J. Leja, J.J. Matthee,
R.P. Naidu, D.J. Setton, H. Übler, G. Venturi, B. Wang, The Astrophysical Journal
Letters 1000 (2026).
date_created: 2026-04-12T22:01:48Z
date_published: 2026-03-20T00:00:00Z
date_updated: 2026-05-04T07:13:07Z
day: '20'
ddc:
- '520'
department:
- _id: JoMa
doi: 10.3847/2041-8213/ae4c88
external_id:
arxiv:
- '2601.09778'
file:
- access_level: open_access
checksum: 1be4f361bf59aa08b8c98ed4f475a463
content_type: application/pdf
creator: dernst
date_created: 2026-05-04T07:11:37Z
date_updated: 2026-05-04T07:11:37Z
file_id: '21784'
file_name: 2026_AstrophysicalJourLetters_Hviding.pdf
file_size: 2821786
relation: main_file
success: 1
file_date_updated: 2026-05-04T07:11:37Z
has_accepted_license: '1'
intvolume: ' 1000'
issue: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal Letters
publication_identifier:
eissn:
- 2041-8213
issn:
- 2041-8205
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The X-ray dot: Exotic dust or a late-stage Little Red Dot?'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1000
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21704'
abstract:
- lang: eng
text: How functional protein sequences are distributed in sequence space is fundamentally
important for evolutionary theory and protein design, particularly if a large
diversity of protein functions are hidden in evolutionarily unexplored areas of
the sequence space. However, this question is understudied in part because experimental
and computational studies use extant sequences as a starting point to study sequence
space. Here, we study whether extant sequences are representative of the entire
functional sequence space. Across thousands of protein families from vertebrates
and bacteria we calculate the dimensionality and the volume of sequence space
occupied by extant homologs. We find that the observed dimensionality and volume
of extant sequence space are minuscule, many orders of magnitude smaller than
what we estimated using a model of protein evolution. Simulating sequence evolution
we then quantify the impact of phylogeny, selection, and epistasis on restricting
the evolutionary exploration of sequence space. We find that sequence evolution
from a single common ancestor, or a single point of origin in sequence space,
is by far the largest limiting factor that reduces the dimensionality and volume
of extant sequence space. These results indicate that there are vast areas of
functional sequence space that have not been explored in evolution because of
the excessive restrictions on natural exploration of the protein sequence space
imposed by the point of origin effect. We suggest that protein design methods
that rely on extant sequences may be limited in their ability to discover truly
novel functions.
acknowledgement: We thank Olga Kalinina for feedback on our manuscript, Vsevolod Kuksin
for fruitful discussions and Lev Tsarin for participation in the design of our models.
This work was supported by Japan Science and Technology Agency as part of Adopting
Sustainable Partnerships for Innovative Research Ecosystem, Grant No. JPMJAP24B2
(F.A.K. and L.H.I.), and Fonds Zur Förderung der Wissenschaftlichen Forschung Grant
ESP253-B (O.O.B.)
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Lada H.
full_name: Isakova, Lada H.
last_name: Isakova
- first_name: Elizaveta
full_name: Streltsova, Elizaveta
id: 57a170da-dc96-11ea-b7c8-ab3565071bf7
last_name: Streltsova
- first_name: Olga
full_name: Bochkareva, Olga
id: C4558D3C-6102-11E9-A62E-F418E6697425
last_name: Bochkareva
orcid: 0000-0003-1006-6639
- first_name: Peter K.
full_name: Vlasov, Peter K.
last_name: Vlasov
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
citation:
ama: Isakova LH, Streltsova E, Bochkareva O, Vlasov PK, Kondrashov F. Descent from
a common ancestor restricts exploration of protein sequence space. Proceedings
of the National Academy of Sciences. 2026;123(14):e2532018123. doi:10.1073/pnas.2532018123
apa: Isakova, L. H., Streltsova, E., Bochkareva, O., Vlasov, P. K., & Kondrashov,
F. (2026). Descent from a common ancestor restricts exploration of protein sequence
space. Proceedings of the National Academy of Sciences. National Academy
of Sciences. https://doi.org/10.1073/pnas.2532018123
chicago: Isakova, Lada H., Elizaveta Streltsova, Olga Bochkareva, Peter K. Vlasov,
and Fyodor Kondrashov. “Descent from a Common Ancestor Restricts Exploration of
Protein Sequence Space.” Proceedings of the National Academy of Sciences.
National Academy of Sciences, 2026. https://doi.org/10.1073/pnas.2532018123.
ieee: L. H. Isakova, E. Streltsova, O. Bochkareva, P. K. Vlasov, and F. Kondrashov,
“Descent from a common ancestor restricts exploration of protein sequence space,”
Proceedings of the National Academy of Sciences, vol. 123, no. 14. National
Academy of Sciences, p. e2532018123, 2026.
ista: Isakova LH, Streltsova E, Bochkareva O, Vlasov PK, Kondrashov F. 2026. Descent
from a common ancestor restricts exploration of protein sequence space. Proceedings
of the National Academy of Sciences. 123(14), e2532018123.
mla: Isakova, Lada H., et al. “Descent from a Common Ancestor Restricts Exploration
of Protein Sequence Space.” Proceedings of the National Academy of Sciences,
vol. 123, no. 14, National Academy of Sciences, 2026, p. e2532018123, doi:10.1073/pnas.2532018123.
short: L.H. Isakova, E. Streltsova, O. Bochkareva, P.K. Vlasov, F. Kondrashov, Proceedings
of the National Academy of Sciences 123 (2026) e2532018123.
date_created: 2026-04-12T22:01:47Z
date_published: 2026-04-07T00:00:00Z
date_updated: 2026-05-04T06:57:31Z
day: '07'
ddc:
- '570'
department:
- _id: UlWa
doi: 10.1073/pnas.2532018123
external_id:
pmid:
- '41915737'
file:
- access_level: open_access
checksum: 11b7a13a359e302498b2367906093a6b
content_type: application/pdf
creator: dernst
date_created: 2026-05-04T06:46:31Z
date_updated: 2026-05-04T06:46:31Z
file_id: '21783'
file_name: 2026_PNAS_Isakova.pdf
file_size: 3355016
relation: main_file
success: 1
file_date_updated: 2026-05-04T06:46:31Z
has_accepted_license: '1'
intvolume: ' 123'
issue: '14'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: e2532018123
pmid: 1
publication: Proceedings of the National Academy of Sciences
publication_identifier:
eissn:
- 1091-6490
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Descent from a common ancestor restricts exploration of protein sequence space
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 123
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21708'
abstract:
- lang: eng
text: On October 4, 2023, a proglacial lake named the South Lhonak lake was the
source of a catastrophic Glacier Lake Outburst Flood (GLOF) in the Teesta river
basin area, resulting in 24 fatalities and leaving over 70 persons missing. The
GLOF also destroyed 13 bridges and a major hydropower plant in the Chungthang
region. Over 60,000 individuals in four districts of Sikkim were impacted by this
GLOF event. This study examines the factors that led to the GLOF event. Our study
shows that the cause of this GLOF was initiated by a landslide, that dumped a
substantial amount (~ 38.31 million m3) of debris into the South Lhonak Lake.
Furthermore, the glacier that was connected to the lake, lost a big chunk of ice
mass (~ 7 million m3) due to calving. The combination of these two processes led
to the collapse of the left lateral moraine that consequently generated flood
waves which breached the terminal moraine dam of the lake. We recommend monitoring
land subsidence and calving events for large proglacial lakes to prevent the disastrous
consequences of such GLOFs in the future.
acknowledgement: This work was carried out independently without the support of any
funding agency or sponsors. The authors thank the SARPROZ team for providing an
evaluation license for the MTInSAR processing software.
article_number: '9741'
article_processing_charge: Yes
article_type: original
author:
- first_name: Litan Kumar
full_name: Mohanty, Litan Kumar
last_name: Mohanty
- first_name: Prateek
full_name: Gantayat, Prateek
id: 02734268-3e8d-11ef-80a1-cec4a088d004
last_name: Gantayat
- first_name: Ankur
full_name: Dixit, Ankur
last_name: Dixit
- first_name: Manik
full_name: Das Adhikari, Manik
last_name: Das Adhikari
- first_name: Rahul
full_name: Biswas, Rahul
last_name: Biswas
- first_name: Vivek Kumar
full_name: Singh, Vivek Kumar
last_name: Singh
citation:
ama: Mohanty LK, GANTAYAT P, Dixit A, Das Adhikari M, Biswas R, Singh VK. Sequence
of events that led to the South Lhonak lake outburst flood in Sikkim, India. Scientific
Reports. 2026;16. doi:10.1038/s41598-026-35895-7
apa: Mohanty, L. K., GANTAYAT, P., Dixit, A., Das Adhikari, M., Biswas, R., &
Singh, V. K. (2026). Sequence of events that led to the South Lhonak lake outburst
flood in Sikkim, India. Scientific Reports. Springer Nature. https://doi.org/10.1038/s41598-026-35895-7
chicago: Mohanty, Litan Kumar, PRATEEK GANTAYAT, Ankur Dixit, Manik Das Adhikari,
Rahul Biswas, and Vivek Kumar Singh. “Sequence of Events That Led to the South
Lhonak Lake Outburst Flood in Sikkim, India.” Scientific Reports. Springer
Nature, 2026. https://doi.org/10.1038/s41598-026-35895-7.
ieee: L. K. Mohanty, P. GANTAYAT, A. Dixit, M. Das Adhikari, R. Biswas, and V. K.
Singh, “Sequence of events that led to the South Lhonak lake outburst flood in
Sikkim, India,” Scientific Reports, vol. 16. Springer Nature, 2026.
ista: Mohanty LK, GANTAYAT P, Dixit A, Das Adhikari M, Biswas R, Singh VK. 2026.
Sequence of events that led to the South Lhonak lake outburst flood in Sikkim,
India. Scientific Reports. 16, 9741.
mla: Mohanty, Litan Kumar, et al. “Sequence of Events That Led to the South Lhonak
Lake Outburst Flood in Sikkim, India.” Scientific Reports, vol. 16, 9741,
Springer Nature, 2026, doi:10.1038/s41598-026-35895-7.
short: L.K. Mohanty, P. GANTAYAT, A. Dixit, M. Das Adhikari, R. Biswas, V.K. Singh,
Scientific Reports 16 (2026).
corr_author: '1'
date_created: 2026-04-12T22:01:48Z
date_published: 2026-03-24T00:00:00Z
date_updated: 2026-05-04T07:54:53Z
day: '24'
ddc:
- '550'
department:
- _id: FrPe
doi: 10.1038/s41598-026-35895-7
external_id:
pmid:
- '41876546'
file:
- access_level: open_access
checksum: cf13f61c38609ce6518d74562319c35f
content_type: application/pdf
creator: dernst
date_created: 2026-05-04T07:24:59Z
date_updated: 2026-05-04T07:24:59Z
file_id: '21785'
file_name: 2026_ScienceAdv_Mohanty.pdf
file_size: 17406006
relation: main_file
success: 1
file_date_updated: 2026-05-04T07:24:59Z
has_accepted_license: '1'
intvolume: ' 16'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
publication: Scientific Reports
publication_identifier:
eissn:
- 2045-2322
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sequence of events that led to the South Lhonak lake outburst flood in Sikkim,
India
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21703'
abstract:
- lang: eng
text: Altermagnetism has recently emerged as a distinct class of collinear antiferromagnets
that break time-reversal symmetry, exhibiting a host of novel properties. Applied
strain has attracted particular attention as a key tuning parameter for altermagnets.
Although several experimental studies have demonstrated the preparation of single-domain
states through a combination of applied strain and magnetic field, the route to
such states remains unclear. Here, we use magneto-optical measurements on single
crystals of MnTe under applied strain to show that, in contrast to previous reports,
strain acts primarily to rotate the Néel vector L continuously. Since the orientation
of L determines the magnetic point group symmetry, this continuous rotation effectively
tunes the symmetry and its associated physical properties. Furthermore, we demonstrate
that built-in strain in free-standing crystals is sufficient to pin L into continuous
textures over millimeter length scales. Together, these results provide guidance
for future device design and open the door to leveraging the Néel vector orientation
as a tunable degree of freedom in spintronic applications.
acknowledgement: "This research was primarily funded by the Quantum Materials (KC2202)
program under the U.S. Department of Energy, Office of Science, Office of Basic
Energy Sciences, Materials Sciences and Engineering Division under Contract No.
DE-AC02-05CH11231, which supported the experimental and theoretical work at the
LBNL and UC Berkeley. N.J.G., R. B. R., and I.I.M.\r\nwere supported by Army Research
Office under Cooperative Agreement Number W911NF- 22-2-0173. H.M.L.N. and V.S. acknowledge
funding through the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
through Grant No. TRR288—422213477, Project No. A10. H.M.L.N. acknowledges financial
support from the Max Planck Society. Research in Dresden benefits from the environment
provided by the DFG Cluster of Excellence ctd.qmat (EXC2147, Project ID 390858490)."
article_number: '2604.07653'
article_processing_charge: No
arxiv: 1
author:
- first_name: Alex Liebman-Peláez
full_name: Alex Liebman-Peláez, Alex Liebman-Peláez
last_name: Alex Liebman-Peláez
- first_name: Jon
full_name: Kruppe, Jon
last_name: Kruppe
- first_name: Resham Babu
full_name: Regmi, Resham Babu
last_name: Regmi
- first_name: Nirmal J.
full_name: Ghimire, Nirmal J.
last_name: Ghimire
- first_name: Yue
full_name: Sun, Yue
last_name: Sun
- first_name: Igor I.
full_name: Mazin, Igor I.
last_name: Mazin
- first_name: Hilary M. L.
full_name: Noad, Hilary M. L.
last_name: Noad
- first_name: James
full_name: Analytis, James
last_name: Analytis
- first_name: Veronika
full_name: Sunko, Veronika
id: 23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3
last_name: Sunko
orcid: 0000-0003-2724-3523
- first_name: Joseph
full_name: Orenstein, Joseph
last_name: Orenstein
citation:
ama: Alex Liebman-Peláez AL-P, Kruppe J, Regmi RB, et al. Strain continuously rotates
the Néel vector in altermagnetic MnTe. arXiv. doi:10.48550/arXiv.2604.07653
apa: Alex Liebman-Peláez, A. L.-P., Kruppe, J., Regmi, R. B., Ghimire, N. J., Sun,
Y., Mazin, I. I., … Orenstein, J. (n.d.). Strain continuously rotates the Néel
vector in altermagnetic MnTe. arXiv. https://doi.org/10.48550/arXiv.2604.07653
chicago: Alex Liebman-Peláez, Alex Liebman-Peláez, Jon Kruppe, Resham Babu Regmi,
Nirmal J. Ghimire, Yue Sun, Igor I. Mazin, Hilary M. L. Noad, James Analytis,
Veronika Sunko, and Joseph Orenstein. “Strain Continuously Rotates the Néel Vector
in Altermagnetic MnTe.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2604.07653.
ieee: A. L.-P. Alex Liebman-Peláez et al., “Strain continuously rotates the
Néel vector in altermagnetic MnTe,” arXiv. .
ista: Alex Liebman-Peláez AL-P, Kruppe J, Regmi RB, Ghimire NJ, Sun Y, Mazin II,
Noad HML, Analytis J, Sunko V, Orenstein J. Strain continuously rotates the Néel
vector in altermagnetic MnTe. arXiv, 2604.07653.
mla: Alex Liebman-Peláez, Alex Liebman-Peláez, et al. “Strain Continuously Rotates
the Néel Vector in Altermagnetic MnTe.” ArXiv, 2604.07653, doi:10.48550/arXiv.2604.07653.
short: A.L.-P. Alex Liebman-Peláez, J. Kruppe, R.B. Regmi, N.J. Ghimire, Y. Sun,
I.I. Mazin, H.M.L. Noad, J. Analytis, V. Sunko, J. Orenstein, ArXiv (n.d.).
date_created: 2026-04-10T14:17:21Z
date_published: 2026-04-08T00:00:00Z
date_updated: 2026-05-04T06:27:12Z
day: '08'
department:
- _id: VeSu
doi: 10.48550/arXiv.2604.07653
external_id:
arxiv:
- '2604.07653'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2604.07653
month: '04'
oa: 1
oa_version: Preprint
publication: arXiv
publication_status: submitted
status: public
title: Strain continuously rotates the Néel vector in altermagnetic MnTe
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21711'
abstract:
- lang: eng
text: 'Background: Low-volume trapping columns are essential for sample enrichment,
desalting, and injection profile focusing on nano-LC–MS-based proteomics. They
enable higher sample loading, improve chromatographic performance, and protect
the analytical column by removing salts and contaminants. Recently, monolithic
trap columns with micropillar architecture have emerged as alternatives to conventionally
packed traps. This study compares the performance of a packed and a micropillar
monolithic trap column for the analysis of tryptic peptides. Methods: A tryptic
digest of HeLa cell lysate was analyzed under identical LC–MS conditions using
both trap types. Peptides were detected at 214 nm and analyzed by nano-ESI on
a Q Exactive Plus Orbitrap. Data were searched against the human UniProt database
(February 2023) using FragPipe v20.0, and statistical evaluation of MaxLFQ intensities
was performed in Perseus using Welch’s t-test and clustering analysis. Results:
Over 2500 proteins were identified with both setups. The packed trap column yielded
more total peptides, particularly those with post-translational modifications
and higher hydrophilicity, whereas the monolithic column favored peptides of intermediate
hydrophobicity. Chromatographic profiles confirmed a slight reduction in the trapping
efficiency of hydrophilic peptides by the monolithic trap. Conclusions: Trap column
design significantly influences peptide recovery and proteome coverage.'
acknowledgement: 'The authors thank Gábor Tóth, Uppsala University, Sweden, and Armel
Nicolas, Institute for Science and Technology Austria, for their support. This research
was conducted during a student residency in Vienna under the auspices of OeAD. ZI:
ICM-2016-03196.'
article_number: '10'
article_processing_charge: Yes
article_type: original
author:
- first_name: Jadranka
full_name: Miletić Vukajlović, Jadranka
last_name: Miletić Vukajlović
- first_name: Bojana
full_name: Ilić, Bojana
last_name: Ilić
- first_name: Bella
full_name: Bruszel, Bella
id: 70abbbb3-88ea-11ec-8e0a-e8c939944834
last_name: Bruszel
- first_name: Tanja
full_name: Panić-Janković, Tanja
last_name: Panić-Janković
- first_name: Goran
full_name: Mitulović, Goran
last_name: Mitulović
citation:
ama: Miletić Vukajlović J, Ilić B, Bruszel B, Panić-Janković T, Mitulović G. Comparison
of the trapping efficiency for tryptic peptides on particle-packed and micro-pillar
trap columns for proteomics analyses. Proteomes. 2026;14(1). doi:10.3390/proteomes14010010
apa: Miletić Vukajlović, J., Ilić, B., Bruszel, B., Panić-Janković, T., & Mitulović,
G. (2026). Comparison of the trapping efficiency for tryptic peptides on particle-packed
and micro-pillar trap columns for proteomics analyses. Proteomes. MDPI.
https://doi.org/10.3390/proteomes14010010
chicago: Miletić Vukajlović, Jadranka, Bojana Ilić, Bella Bruszel, Tanja Panić-Janković,
and Goran Mitulović. “Comparison of the Trapping Efficiency for Tryptic Peptides
on Particle-Packed and Micro-Pillar Trap Columns for Proteomics Analyses.” Proteomes.
MDPI, 2026. https://doi.org/10.3390/proteomes14010010.
ieee: J. Miletić Vukajlović, B. Ilić, B. Bruszel, T. Panić-Janković, and G. Mitulović,
“Comparison of the trapping efficiency for tryptic peptides on particle-packed
and micro-pillar trap columns for proteomics analyses,” Proteomes, vol.
14, no. 1. MDPI, 2026.
ista: Miletić Vukajlović J, Ilić B, Bruszel B, Panić-Janković T, Mitulović G. 2026.
Comparison of the trapping efficiency for tryptic peptides on particle-packed
and micro-pillar trap columns for proteomics analyses. Proteomes. 14(1), 10.
mla: Miletić Vukajlović, Jadranka, et al. “Comparison of the Trapping Efficiency
for Tryptic Peptides on Particle-Packed and Micro-Pillar Trap Columns for Proteomics
Analyses.” Proteomes, vol. 14, no. 1, 10, MDPI, 2026, doi:10.3390/proteomes14010010.
short: J. Miletić Vukajlović, B. Ilić, B. Bruszel, T. Panić-Janković, G. Mitulović,
Proteomes 14 (2026).
date_created: 2026-04-12T22:01:49Z
date_published: 2026-03-01T00:00:00Z
date_updated: 2026-05-04T10:36:21Z
day: '01'
ddc:
- '540'
department:
- _id: MassSpec
doi: 10.3390/proteomes14010010
external_id:
pmid:
- '41893725'
file:
- access_level: open_access
checksum: 1e0c66bbf4b6e0be626a8639ea664b63
content_type: application/pdf
creator: dernst
date_created: 2026-05-04T10:31:35Z
date_updated: 2026-05-04T10:31:35Z
file_id: '21790'
file_name: 2026_Proteomes_Vukajlovic.pdf
file_size: 1009723
relation: main_file
success: 1
file_date_updated: 2026-05-04T10:31:35Z
has_accepted_license: '1'
intvolume: ' 14'
issue: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
publication: Proteomes
publication_identifier:
eissn:
- 2227-7382
publication_status: published
publisher: MDPI
quality_controlled: '1'
scopus_import: '1'
status: public
title: Comparison of the trapping efficiency for tryptic peptides on particle-packed
and micro-pillar trap columns for proteomics analyses
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21712'
abstract:
- lang: eng
text: Supermassive black hole binary (SMBHB) systems are expected to form as a consequence
of galaxy mergers. At subparsec separations, SMBHBs can be identified as quasars
with periodic variability, with previous periodicity searches uncovering significant
candidates. However, these searches focused primarily on sinusoidal signals, while
theoretical models and hydrodynamical simulations predict that binaries produce
more complex non-sinusoidal pulse shapes. Here we examine the efficacy of the
Lomb–Scargle periodogram (LSP; one of the most popular tools for periodicity searches
in unevenly sampled lightcurves) to detect periodicities with a sawtooth shape
mimicking results of hydrodynamical simulations. We simulate idealized well-sampled
lightcurves, lightcurves that mimic the data in the Palomar Transient Factory
(PTF) analyzed in M. Charisi et al. (2016), and lightcurves that resemble our
expectations for single-band data in the upcoming Legacy Survey of Space and Time
(LSST) of the Rubin Observatory. We approximate quasar variability with a damped
random walk (DRW) model, inject sinusoidal and sawtooth pulse shapes, and assess
their statistical significance. We find that in the presence of red noise, the
LSP detects a relatively low fraction of the sinusoidal signals (∼45%, ∼24%, and
∼23%, in the PTF-like, idealized, and LSST-like lightcurves, respectively). The
fraction is significantly reduced for sawtooth periodicity (with only ∼9% in PTF-like
and ∼1% in idealized and LSST-like lightcurves). These low recovery rates imply
that previous searches have missed the large majority of binaries. They also have
significant implications for the detection of SMBHBs in upcoming LSST necessitating
the development of advanced tools that go beyond the simple LSP.
acknowledgement: M.C. acknowledges support by the European Union (ERC; MMMonsters,
101117624). This work was also supported in part by NASA grants 80NSSC24K0440 and
80NSSC22K0822. This research used the resources of the Center for Institutional
Research Computing at Washington State University.
article_number: '316'
article_processing_charge: Yes
article_type: original
author:
- first_name: Allison
full_name: Lin, Allison
last_name: Lin
- first_name: Maria
full_name: Charisi, Maria
last_name: Charisi
- first_name: Zoltán
full_name: Haiman, Zoltán
id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
last_name: Haiman
orcid: 0000-0003-3633-5403
citation:
ama: Lin A, Charisi M, Haiman Z. Lomb-scargle periodogram struggles with non-sinusoidal
supermassive Black Hole binary signatures in quasar lightcurves. The Astrophysical
Journal. 2026;997(2). doi:10.3847/1538-4357/ae29a7
apa: Lin, A., Charisi, M., & Haiman, Z. (2026). Lomb-scargle periodogram struggles
with non-sinusoidal supermassive Black Hole binary signatures in quasar lightcurves.
The Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ae29a7
chicago: Lin, Allison, Maria Charisi, and Zoltán Haiman. “Lomb-Scargle Periodogram
Struggles with Non-Sinusoidal Supermassive Black Hole Binary Signatures in Quasar
Lightcurves.” The Astrophysical Journal. IOP Publishing, 2026. https://doi.org/10.3847/1538-4357/ae29a7.
ieee: A. Lin, M. Charisi, and Z. Haiman, “Lomb-scargle periodogram struggles with
non-sinusoidal supermassive Black Hole binary signatures in quasar lightcurves,”
The Astrophysical Journal, vol. 997, no. 2. IOP Publishing, 2026.
ista: Lin A, Charisi M, Haiman Z. 2026. Lomb-scargle periodogram struggles with
non-sinusoidal supermassive Black Hole binary signatures in quasar lightcurves.
The Astrophysical Journal. 997(2), 316.
mla: Lin, Allison, et al. “Lomb-Scargle Periodogram Struggles with Non-Sinusoidal
Supermassive Black Hole Binary Signatures in Quasar Lightcurves.” The Astrophysical
Journal, vol. 997, no. 2, 316, IOP Publishing, 2026, doi:10.3847/1538-4357/ae29a7.
short: A. Lin, M. Charisi, Z. Haiman, The Astrophysical Journal 997 (2026).
date_created: 2026-04-12T22:01:49Z
date_published: 2026-02-01T00:00:00Z
date_updated: 2026-05-04T10:26:59Z
day: '01'
ddc:
- '520'
department:
- _id: ZoHa
doi: 10.3847/1538-4357/ae29a7
file:
- access_level: open_access
checksum: 5162d1539ef7d10927ef73d8b4500017
content_type: application/pdf
creator: dernst
date_created: 2026-05-04T10:24:49Z
date_updated: 2026-05-04T10:24:49Z
file_id: '21789'
file_name: 2026_AstrophysicalJour_Lin.pdf
file_size: 2619679
relation: main_file
success: 1
file_date_updated: 2026-05-04T10:24:49Z
has_accepted_license: '1'
intvolume: ' 997'
issue: '2'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Lomb-scargle periodogram struggles with non-sinusoidal supermassive Black Hole
binary signatures in quasar lightcurves
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 997
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21707'
abstract:
- lang: eng
text: Structural and functional differences between brain hemispheres are a common
feature of animal nervous systems with reduced bilateral asymmetry often linked
to impaired cognitive performance. How neuronal left-right asymmetry is initiated
and integrated into a bilaterally symmetrical ground pattern is poorly understood.
Here, we show that the directional asymmetry of a Drosophila central brain circuit
originates from axonal interactions of two types of bilateral pioneer neurons.
Subsequent recruitment of neighboring neurons into the asymmetric neuropil primordium
results in hemisphere-specific microcircuits. Circuit lateralization requires
dynamic expression of the cell adhesion molecule Fasciclin 2 to maintain structural
plasticity in axonal remodeling. Reduced circuit asymmetry following cell type–specific
Fasciclin 2 manipulation affects adult brain function. These results reveal an
unexpected degree of developmental plasticity of late-born Drosophila neurons
in the formation of a circuit node via the lateralized recruitment of symmetric
circuit components.
acknowledgement: "We thank I. Salecker (Flybow), B. Altenhein (Fas2-Gal4Mz507), A.
Nose (UAS-intra- and extra-Fas2::YFP), and C. S. Goodman (UAS-Fas2PEST+/−), as well
as the Bloomington Stock Center for providing materials and fly stocks. We thank
S. Waddell and the lab, especially B. Senapati, for providing the opportunity to
conduct memory experiments at the CNCB, University of Oxford, and for supervision
and discussions during this period. We also thank W. Kallina, S. Ilgerl, D. Bartel,
A. Grimm, and A. Litin for technical support and the Hummel Lab for stimulating
discussions and critical comments on the manuscript. We acknowledge the early exploratory
work of A. Mattia, S. Trkulja, C. Schönherr, S. Bogner, B. Simpson, L. Tomasek,
H. Roth, H. Vokač, R. Gredler, F. Kapelari, T. Kolarova, C. Ignitsch, Á. Bautista-Soldevila,
and M. Kassem.\r\nThis research was funded by the University of Vienna, the Vienna
Doctoral School Cognition, Behaviour and Neuroscience (uni:docs fellowship) (to
J.W.M.) and by the Austrian Science Fund (FWF) (Cluster of Excellence Neuronal Circuits
in Health and Disease, grant DOI 10.55776/COE16; https://www.fwf.ac.at/en/research-radar/10.55776/COE16)
(to T.H.). For open access purposes, the author has applied a CC BY public copyright
license to any author-accepted manuscript version arising from this submission."
article_number: eaea6020
article_processing_charge: Yes
article_type: original
author:
- first_name: Johann W.
full_name: Markovitsch, Johann W.
last_name: Markovitsch
- first_name: Daniel
full_name: Mitić, Daniel
last_name: Mitić
- first_name: Alisa
full_name: Del Pilar Jiménez García, Alisa
last_name: Del Pilar Jiménez García
- first_name: Alsberga
full_name: Zane, Alsberga
id: 60f7509a-f652-11ea-9d86-b963d6490d7c
last_name: Zane
orcid: 0009-0003-0415-7603
- first_name: Sarah
full_name: Kainz, Sarah
last_name: Kainz
- first_name: Rashmit
full_name: Kaur, Rashmit
last_name: Kaur
- first_name: Thomas
full_name: Hummel, Thomas
last_name: Hummel
citation:
ama: Markovitsch JW, Mitić D, Del Pilar Jiménez García A, et al. Sequential formation
of Drosophila circuit asymmetry via prolonged structural plasticity. Science
Advances. 2026;12(13). doi:10.1126/sciadv.aea6020
apa: Markovitsch, J. W., Mitić, D., Del Pilar Jiménez García, A., Zane, A., Kainz,
S., Kaur, R., & Hummel, T. (2026). Sequential formation of Drosophila circuit
asymmetry via prolonged structural plasticity. Science Advances. American
Association for the Advancement of Science. https://doi.org/10.1126/sciadv.aea6020
chicago: Markovitsch, Johann W., Daniel Mitić, Alisa Del Pilar Jiménez García, Alsberga
Zane, Sarah Kainz, Rashmit Kaur, and Thomas Hummel. “Sequential Formation of Drosophila
Circuit Asymmetry via Prolonged Structural Plasticity.” Science Advances.
American Association for the Advancement of Science, 2026. https://doi.org/10.1126/sciadv.aea6020.
ieee: J. W. Markovitsch et al., “Sequential formation of Drosophila circuit
asymmetry via prolonged structural plasticity,” Science Advances, vol.
12, no. 13. American Association for the Advancement of Science, 2026.
ista: Markovitsch JW, Mitić D, Del Pilar Jiménez García A, Zane A, Kainz S, Kaur
R, Hummel T. 2026. Sequential formation of Drosophila circuit asymmetry via prolonged
structural plasticity. Science Advances. 12(13), eaea6020.
mla: Markovitsch, Johann W., et al. “Sequential Formation of Drosophila Circuit
Asymmetry via Prolonged Structural Plasticity.” Science Advances, vol.
12, no. 13, eaea6020, American Association for the Advancement of Science, 2026,
doi:10.1126/sciadv.aea6020.
short: J.W. Markovitsch, D. Mitić, A. Del Pilar Jiménez García, A. Zane, S. Kainz,
R. Kaur, T. Hummel, Science Advances 12 (2026).
date_created: 2026-04-12T22:01:48Z
date_published: 2026-03-27T00:00:00Z
date_updated: 2026-05-04T09:18:06Z
day: '27'
ddc:
- '570'
department:
- _id: MiSi
- _id: GradSch
doi: 10.1126/sciadv.aea6020
file:
- access_level: open_access
checksum: 3eed470fe73e53d2a8d55d6fba6934e3
content_type: application/pdf
creator: dernst
date_created: 2026-05-04T09:16:36Z
date_updated: 2026-05-04T09:16:36Z
file_id: '21786'
file_name: 2026_ScienceAdv_Markovitsch.pdf
file_size: 11101140
relation: main_file
success: 1
file_date_updated: 2026-05-04T09:16:36Z
has_accepted_license: '1'
intvolume: ' 12'
issue: '13'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sequential formation of Drosophila circuit asymmetry via prolonged structural
plasticity
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21713'
abstract:
- lang: eng
text: GW231123 represents the most massive binary–black hole merger detected to
date, lying firmly within, or even above, the pair-instability mass gap. The component
spins are both exceptionally high (a1 = 0.90 +0.10/-0.19, a2 = 0.80 +0.20/-0.51),
which is difficult to explain with repeated mergers. Here we show that the black
hole spin vectors are closely aligned with each other while significantly tilted
relative to the binary’s orbital angular momentum, pointing to a common accretion-driven
origin. We examine astrophysical formation channels capable of producing near-equal,
high-mass, and mutually aligned spins consistent with GW231123—particularly binaries
embedded in AGN disks and Population III remnants, which grew via coherent misaligned
gas accretion. We further argue that other high-mass, high-spin events, e.g.,
GW190521, may share a similar evolutionary pathway. These findings underscore
the critical role of sustained, coherent accretion in shaping the most extreme
black hole binaries.
acknowledgement: The authors thank Davide Gerosa and Matthew Mould for valuable suggestions.
We are grateful for support by the National Science Foundation under grant No. PHY-2309024
(I.B.) and by NASA under grants 80NSSC22K0822 and 80NSSC24K0440 (Z.H.). We used
OpenAI’s ChatGPT (OpenAI 2025) during the preparation of this manuscript. This material
is based upon work supported by NSF’s LIGO Laboratory, which is a major facility
fully funded by the National Science Foundation.
article_number: L44
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Imre
full_name: Bartos, Imre
last_name: Bartos
- first_name: Zoltán
full_name: Haiman, Zoltán
id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
last_name: Haiman
orcid: 0000-0003-3633-5403
citation:
ama: 'Bartos I, Haiman Z. Accretion is all you need: Black Hole spin alignment in
merger GW231123 indicates accretion pathway. The Astrophysical Journal Letters.
2026;996(2). doi:10.3847/2041-8213/ae2bff'
apa: 'Bartos, I., & Haiman, Z. (2026). Accretion is all you need: Black Hole
spin alignment in merger GW231123 indicates accretion pathway. The Astrophysical
Journal Letters. IOP Publishing. https://doi.org/10.3847/2041-8213/ae2bff'
chicago: 'Bartos, Imre, and Zoltán Haiman. “Accretion Is All You Need: Black Hole
Spin Alignment in Merger GW231123 Indicates Accretion Pathway.” The Astrophysical
Journal Letters. IOP Publishing, 2026. https://doi.org/10.3847/2041-8213/ae2bff.'
ieee: 'I. Bartos and Z. Haiman, “Accretion is all you need: Black Hole spin alignment
in merger GW231123 indicates accretion pathway,” The Astrophysical Journal
Letters, vol. 996, no. 2. IOP Publishing, 2026.'
ista: 'Bartos I, Haiman Z. 2026. Accretion is all you need: Black Hole spin alignment
in merger GW231123 indicates accretion pathway. The Astrophysical Journal Letters.
996(2), L44.'
mla: 'Bartos, Imre, and Zoltán Haiman. “Accretion Is All You Need: Black Hole Spin
Alignment in Merger GW231123 Indicates Accretion Pathway.” The Astrophysical
Journal Letters, vol. 996, no. 2, L44, IOP Publishing, 2026, doi:10.3847/2041-8213/ae2bff.'
short: I. Bartos, Z. Haiman, The Astrophysical Journal Letters 996 (2026).
corr_author: '1'
date_created: 2026-04-12T22:01:49Z
date_published: 2026-01-10T00:00:00Z
date_updated: 2026-05-04T09:54:18Z
day: '10'
ddc:
- '520'
department:
- _id: ZoHa
doi: 10.3847/2041-8213/ae2bff
external_id:
arxiv:
- '2508.08558'
file:
- access_level: open_access
checksum: ac46ba3d13f0150ccbc42665bed3ae47
content_type: application/pdf
creator: dernst
date_created: 2026-05-04T09:49:53Z
date_updated: 2026-05-04T09:49:53Z
file_id: '21788'
file_name: 2026_AstrophysicalJourLetters_Bartos.pdf
file_size: 866725
relation: main_file
success: 1
file_date_updated: 2026-05-04T09:49:53Z
has_accepted_license: '1'
intvolume: ' 996'
issue: '2'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal Letters
publication_identifier:
eissn:
- 2041-8213
issn:
- 2041-8205
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Accretion is all you need: Black Hole spin alignment in merger GW231123 indicates
accretion pathway'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 996
year: '2026'
...
---
OA_place: publisher
OA_type: gold
_id: '21710'
abstract:
- lang: eng
text: "Early results from JWST suggest that Epoch of Reionization (EoR) galaxies
produce copious ionizing photons, which, if they escape efficiently, could cause
reionization to occur too early. We study this problem using JWST imaging and
prism spectroscopy for 412 galaxies at 4.5 < z < 9.0. We fit these data simultaneously
with stellar population and nebular emission models that include a parameter for
the fraction of ionizing photons that escape the galaxy, fesc. We find that the
ionization production efficiency, ξion = Q(H0)/LUV, increases with redshift and
decreasing UV luminosity, but shows significant scatter, (log ion z, MUV) 0.3
dex. The inferred escape fractions averaged over the population are low, ranging
from〈fesc〉 ≃ 2.6% ± 1.4% at 6 < z < 9 to 6.5% ± 2.2% at 4.5 < z < 6, with weak
or no indication of evolution with redshift. This implies that in our models most
of the ionizing photons need to be absorbed to account for the nebular emission.
We compute the impact of our results on reionization, including the distributions
for ξion and fesc, and the evolution and uncertainty of the UV luminosity function.
Considering galaxies brighter than MUV < −16 mag would produce an intergalactic
medium hydrogen-ionized fraction of xe = 0.5 at 5.3 < z < 5.8, possibly too late
compared to constraints from from quasistellar\r\nobject (QSO) sight lines. Including
fainter galaxies, MUV < −14 mag, we obtain xe = 0.5 at 6.0 < z < 8.1, fully consistent
with QSO and cosmic microwave background data. This implies that EoR galaxies
produce plenty of ionizing photons, but that these do not efficiently escape.
This may be a result of high gas column densities combined with burstier star
formation histories, which limit the time massive stars are able to clear channels
through the gas for ionizing photons to escape."
acknowledgement: "We wish to thank our colleagues in the CEERS collaboration for their
hard work and valuable contributions on this project. We extend our sincerest thanks
to the anonymous referee whose critical and constructive report improved the quality
of this manuscript. We also thank the JADES team for providing an excellent dataset
for science. We with to thank colleagues for valuable discussions, feedback, and
suggestions, including John Chisholm, Kevin Huffenberger, Jessica\r\nMeh, Julian
Muñoz, Irene Shivaei, Justin Spilker, Aaron Smith, and Romain Teyssier.\r\nPortions
of this research were conducted with the advanced computing resources provided by
Texas A&M High Performance Research Computing (HPRC, http://hprc.tamu.edu). This
work benefited from support from the George P. and Cynthia Woods Mitchell Institute
for Fundamental Physics and Astronomy at Texas A&M University. CP thanks Marsha
and Ralph Schilling for generous support of this research. This work was partially
support by the Future Investigators in NASA Earth and Space Science and Technology
(FINESST) program grant No. 80NSSC23K1487. R.A. acknowledges support of grant PID2023-147386NB-I00
funded by MICIU/AEI/10.13039/501100011033 and by ERDF/EU, and the Severo Ochoa grant
CEX2021-001131-S funded by MCIN/AEI/10.13039/50110001103. A.C.C. acknowledges support
from a UKRI Frontier Research Guarantee Grant (PI Carnall; grant reference EP/Y037065/1)
This work acknowledges support from the NASA/ESA/CSA James Webb Space Telescope
through the\r\nSpace Telescope Science Institute, which is operated by the Association
of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-03127.
Support for program JWST-ERS-01345.009-A, JWST-GO-02079.013-A, JWST-GO-06368.011-A,
and JWST-GO-01837.030-A, was provided by NASA through a grant from the Space Telescope
Science Institute, which is operated by the Association of Universities for Research
in Astronomy, Inc., under NASA contract NAS 5-03127. This work made use of v2.2
of the Binary Population\r\nand Spectral Synthesis (BPASS) models as described in
E. R. Stanway & J. J. Eldridge (2018)."
article_number: '111'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Casey
full_name: Papovich, Casey
last_name: Papovich
- first_name: Justin W.
full_name: Cole, Justin W.
last_name: Cole
- first_name: Weida
full_name: Hu, Weida
last_name: Hu
- first_name: Steven L.
full_name: Finkelstein, Steven L.
last_name: Finkelstein
- first_name: Lu
full_name: Shen, Lu
last_name: Shen
- first_name: Pablo
full_name: Arrabal Haro, Pablo
last_name: Arrabal Haro
- first_name: Ricardo O.
full_name: Amorín, Ricardo O.
last_name: Amorín
- first_name: Bren E.
full_name: Backhaus, Bren E.
last_name: Backhaus
- first_name: Micaela B.
full_name: Bagley, Micaela B.
last_name: Bagley
- first_name: Rachana
full_name: Bhatawdekar, Rachana
last_name: Bhatawdekar
- first_name: Antonello
full_name: Calabrò, Antonello
last_name: Calabrò
- first_name: Adam C.
full_name: Carnall, Adam C.
last_name: Carnall
- first_name: Nikko J.
full_name: Cleri, Nikko J.
last_name: Cleri
- first_name: Emanuele
full_name: Daddi, Emanuele
last_name: Daddi
- first_name: Mark
full_name: Dickinson, Mark
last_name: Dickinson
- first_name: Norman A.
full_name: Grogin, Norman A.
last_name: Grogin
- first_name: Benne W.
full_name: Holwerda, Benne W.
last_name: Holwerda
- first_name: Anne E.
full_name: Jaskot, Anne E.
last_name: Jaskot
- first_name: Anton M.
full_name: Koekemoer, Anton M.
last_name: Koekemoer
- first_name: Mario
full_name: Llerena, Mario
last_name: Llerena
- first_name: Ray A.
full_name: Lucas, Ray A.
last_name: Lucas
- first_name: Sara
full_name: Mascia, Sara
id: edaf889c-c7cd-11ef-ab1b-bb28c431bd29
last_name: Mascia
- first_name: Fabio
full_name: Pacucci, Fabio
last_name: Pacucci
- first_name: Laura
full_name: Pentericci, Laura
last_name: Pentericci
- first_name: Pablo G.
full_name: Pérez-González, Pablo G.
last_name: Pérez-González
- first_name: Nor
full_name: Pirzkal, Nor
last_name: Pirzkal
- first_name: Srinivasan
full_name: Raghunathan, Srinivasan
last_name: Raghunathan
- first_name: Lise Marie
full_name: Seillé, Lise Marie
last_name: Seillé
- first_name: Rachel S.
full_name: Somerville, Rachel S.
last_name: Somerville
- first_name: L. Y.Aaron
full_name: Yung, L. Y.Aaron
last_name: Yung
citation:
ama: Papovich C, Cole JW, Hu W, et al. Galaxies in the epoch of reionization are
all bark and no bite-plenty of ionizing photons, low escape fractions. The
Astrophysical Journal. 2026;1000(1). doi:10.3847/1538-4357/ae3b25
apa: Papovich, C., Cole, J. W., Hu, W., Finkelstein, S. L., Shen, L., Arrabal Haro,
P., … Yung, L. Y. A. (2026). Galaxies in the epoch of reionization are all bark
and no bite-plenty of ionizing photons, low escape fractions. The Astrophysical
Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ae3b25
chicago: Papovich, Casey, Justin W. Cole, Weida Hu, Steven L. Finkelstein, Lu Shen,
Pablo Arrabal Haro, Ricardo O. Amorín, et al. “Galaxies in the Epoch of Reionization
Are All Bark and No Bite-Plenty of Ionizing Photons, Low Escape Fractions.” The
Astrophysical Journal. IOP Publishing, 2026. https://doi.org/10.3847/1538-4357/ae3b25.
ieee: C. Papovich et al., “Galaxies in the epoch of reionization are all
bark and no bite-plenty of ionizing photons, low escape fractions,” The Astrophysical
Journal, vol. 1000, no. 1. IOP Publishing, 2026.
ista: Papovich C, Cole JW, Hu W, Finkelstein SL, Shen L, Arrabal Haro P, Amorín
RO, Backhaus BE, Bagley MB, Bhatawdekar R, Calabrò A, Carnall AC, Cleri NJ, Daddi
E, Dickinson M, Grogin NA, Holwerda BW, Jaskot AE, Koekemoer AM, Llerena M, Lucas
RA, Mascia S, Pacucci F, Pentericci L, Pérez-González PG, Pirzkal N, Raghunathan
S, Seillé LM, Somerville RS, Yung LYA. 2026. Galaxies in the epoch of reionization
are all bark and no bite-plenty of ionizing photons, low escape fractions. The
Astrophysical Journal. 1000(1), 111.
mla: Papovich, Casey, et al. “Galaxies in the Epoch of Reionization Are All Bark
and No Bite-Plenty of Ionizing Photons, Low Escape Fractions.” The Astrophysical
Journal, vol. 1000, no. 1, 111, IOP Publishing, 2026, doi:10.3847/1538-4357/ae3b25.
short: C. Papovich, J.W. Cole, W. Hu, S.L. Finkelstein, L. Shen, P. Arrabal Haro,
R.O. Amorín, B.E. Backhaus, M.B. Bagley, R. Bhatawdekar, A. Calabrò, A.C. Carnall,
N.J. Cleri, E. Daddi, M. Dickinson, N.A. Grogin, B.W. Holwerda, A.E. Jaskot, A.M.
Koekemoer, M. Llerena, R.A. Lucas, S. Mascia, F. Pacucci, L. Pentericci, P.G.
Pérez-González, N. Pirzkal, S. Raghunathan, L.M. Seillé, R.S. Somerville, L.Y.A.
Yung, The Astrophysical Journal 1000 (2026).
date_created: 2026-04-12T22:01:49Z
date_published: 2026-03-20T00:00:00Z
date_updated: 2026-05-04T10:44:57Z
day: '20'
ddc:
- '520'
department:
- _id: JoMa
doi: 10.3847/1538-4357/ae3b25
external_id:
arxiv:
- '2505.08870'
file:
- access_level: open_access
checksum: 0031a6f197a3fa8c2845de10b6bdc696
content_type: application/pdf
creator: dernst
date_created: 2026-05-04T10:40:07Z
date_updated: 2026-05-04T10:40:07Z
file_id: '21791'
file_name: 2026_AstrophysicalJour_Papovich.pdf
file_size: 6670398
relation: main_file
success: 1
file_date_updated: 2026-05-04T10:40:07Z
has_accepted_license: '1'
intvolume: ' 1000'
issue: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Galaxies in the epoch of reionization are all bark and no bite-plenty of ionizing
photons, low escape fractions
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1000
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21715'
abstract:
- lang: eng
text: New populations of red active galactic nuclei (known as “little red dots”)
discovered by JWST exhibit remarkable spectral energy distributions. Leveraging
X-ray through far-infrared observations of two of the most luminous known little
red dots, we directly measure their bolometric luminosities. We find evidence
that more than half of the bolometric luminosity likely emerges in the rest-frame
optical, with Lbol/L5100 = 5, roughly half the value for “standard” active galactic
nuclei. Meanwhile, the X-ray emitting corona, UV-emitting blackbody, and reprocessed
mid to far-infrared emission are all considerably subdominant, assuming that the
far-infrared luminosity is well below current measured limits. We present new
bolometric corrections that dramatically lower inferred bolometric luminosities
by a factor of 10 compared to published values in the literature. These bolometric
corrections are in accord with expectations from models in which gas absorption
and reprocessing are responsible for the red rest-frame optical colors of little
red dots. We discuss how this lowered luminosity scale suggests a lower mass scale
for the population by at least an order of magnitude (e.g., ∼105–107 M⊙ black
holes, and ∼108 M⊙ galaxies), alleviating tensions with clustering, overmassive
black holes, and the integrated black hole mass density in the Universe.
acknowledgement: "We benefit from the following JWST programs: UNCOVER (JWST/GO #2561;
Labbé & Bezanson); ALT (JWST-GO #3516; Naidu & Matthee); MegaScience (JWST-GO #4111;
Suess); RUBIES (JWST-GO #4233; de Graaff & Brammer); PRIMER (JWST/GO #1837; Dunlop).\r\n\r\nWe
acknowledge funding from NSF/AAG #2306950, JWST-GO-02561, JWST-GO-03516, and JWST-GO-04111,
provided through a grant from the STScI under NASA contract NAS5-03127. I.L. acknowledges
support from Australian Research Council Future Fellowship FT220100798. K.G. and
T.N. acknowledge support from Australian Research Council Laureate Fellowship FL180100060.
A.Z. acknowledges support by grant No. 2020750 from the United States-Israel Binational
Science Foundation (BSF) and grant No. 2109066 from the United States National Science
Foundation (NSF); by the Ministry of Science & Technology, Israel; and by the Israel
Science Foundation grant No. 864/23. J.M. and I.K. are funded by the European Union
(ERC, AGENTS, 101076224). Views and opinions expressed are, however, those of the
author(s) only and do not necessarily reflect those of the European Union or the
European Research Council. Neither the European Union nor the granting authority
can be held responsible for them. Y.F. acknowledges support from JSPS KAKENHI grant
No. JSPS KAKENHI grant Nos. JP22K21349 and JP23K13149. This work has received funding
from the Swiss State Secretariat for Education, Research and Innovation (SERI) under
contract No. MB22.00072, as well as from the Swiss National Science Foundation (SNSF)
through project grant 200020_207349. The Cosmic Dawn Center (DAWN) is funded by
the Danish National Research Foundation under grant DNRF140. Support for this work
for RPN was provided by NASA through the NASA Hubble Fellowship grant HST-HF2-51515.001-A
awarded by the Space Telescope Science Institute, which is operated by the Association
of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-26555.
The work of CCW is supported by NOIRLab, which is managed by the Association of
Universities for Research in Astronomy (AURA) under a cooperative agreement with
the National Science Foundation. J.M. acknowledges funding by the European Union
(ERC, AGENTS, 101076224). R.E.H. acknowledges support by the German Aerospace Center
(DLR) and the Federal Ministry for Economic Affairs and Energy (BMWi) through program
50OR2403 “RUBIES.”"
article_number: '129'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Jenny E.
full_name: Greene, Jenny E.
last_name: Greene
- first_name: David J.
full_name: Setton, David J.
last_name: Setton
- first_name: Lukas J.
full_name: Furtak, Lukas J.
last_name: Furtak
- first_name: Rohan P.
full_name: Naidu, Rohan P.
last_name: Naidu
- first_name: Marta
full_name: Volonteri, Marta
last_name: Volonteri
- first_name: Pratika
full_name: Dayal, Pratika
last_name: Dayal
- first_name: Ivo
full_name: Labbe, Ivo
last_name: Labbe
- first_name: Pieter
full_name: Van Dokkum, Pieter
last_name: Van Dokkum
- first_name: Rachel
full_name: Bezanson, Rachel
last_name: Bezanson
- first_name: Gabriel
full_name: Brammer, Gabriel
last_name: Brammer
- first_name: Sam E.
full_name: Cutler, Sam E.
last_name: Cutler
- first_name: Karl
full_name: Glazebrook, Karl
last_name: Glazebrook
- first_name: Anna
full_name: De Graaff, Anna
last_name: De Graaff
- first_name: Michaela
full_name: Hirschmann, Michaela
last_name: Hirschmann
- first_name: Raphael E.
full_name: Hviding, Raphael E.
last_name: Hviding
- first_name: Vasily
full_name: Kokorev, Vasily
last_name: Kokorev
- first_name: Joel
full_name: Leja, Joel
last_name: Leja
- first_name: Hanpu
full_name: Liu, Hanpu
last_name: Liu
- first_name: Yilun
full_name: Ma, Yilun
last_name: Ma
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Themiya
full_name: Nanayakkara, Themiya
last_name: Nanayakkara
- first_name: Pascal A.
full_name: Oesch, Pascal A.
last_name: Oesch
- first_name: Richard
full_name: Pan, Richard
last_name: Pan
- first_name: Sedona H.
full_name: Price, Sedona H.
last_name: Price
- first_name: Justin S.
full_name: Spilker, Justin S.
last_name: Spilker
- first_name: Bingjie
full_name: Wang, Bingjie
last_name: Wang
- first_name: John R.
full_name: Weaver, John R.
last_name: Weaver
- first_name: Katherine E.
full_name: Whitaker, Katherine E.
last_name: Whitaker
- first_name: Christina C.
full_name: Williams, Christina C.
last_name: Williams
- first_name: Adi
full_name: Zitrin, Adi
last_name: Zitrin
citation:
ama: 'Greene JE, Setton DJ, Furtak LJ, et al. What you see is what you get: Empirically
measured bolometric luminosities of Little Red Dots. The Astrophysical Journal.
2026;996(2). doi:10.3847/1538-4357/ae1836'
apa: 'Greene, J. E., Setton, D. J., Furtak, L. J., Naidu, R. P., Volonteri, M.,
Dayal, P., … Zitrin, A. (2026). What you see is what you get: Empirically measured
bolometric luminosities of Little Red Dots. The Astrophysical Journal.
IOP Publishing. https://doi.org/10.3847/1538-4357/ae1836'
chicago: 'Greene, Jenny E., David J. Setton, Lukas J. Furtak, Rohan P. Naidu, Marta
Volonteri, Pratika Dayal, Ivo Labbe, et al. “What You See Is What You Get: Empirically
Measured Bolometric Luminosities of Little Red Dots.” The Astrophysical Journal.
IOP Publishing, 2026. https://doi.org/10.3847/1538-4357/ae1836.'
ieee: 'J. E. Greene et al., “What you see is what you get: Empirically measured
bolometric luminosities of Little Red Dots,” The Astrophysical Journal,
vol. 996, no. 2. IOP Publishing, 2026.'
ista: 'Greene JE, Setton DJ, Furtak LJ, Naidu RP, Volonteri M, Dayal P, Labbe I,
Van Dokkum P, Bezanson R, Brammer G, Cutler SE, Glazebrook K, De Graaff A, Hirschmann
M, Hviding RE, Kokorev V, Leja J, Liu H, Ma Y, Matthee JJ, Nanayakkara T, Oesch
PA, Pan R, Price SH, Spilker JS, Wang B, Weaver JR, Whitaker KE, Williams CC,
Zitrin A. 2026. What you see is what you get: Empirically measured bolometric
luminosities of Little Red Dots. The Astrophysical Journal. 996(2), 129.'
mla: 'Greene, Jenny E., et al. “What You See Is What You Get: Empirically Measured
Bolometric Luminosities of Little Red Dots.” The Astrophysical Journal,
vol. 996, no. 2, 129, IOP Publishing, 2026, doi:10.3847/1538-4357/ae1836.'
short: J.E. Greene, D.J. Setton, L.J. Furtak, R.P. Naidu, M. Volonteri, P. Dayal,
I. Labbe, P. Van Dokkum, R. Bezanson, G. Brammer, S.E. Cutler, K. Glazebrook,
A. De Graaff, M. Hirschmann, R.E. Hviding, V. Kokorev, J. Leja, H. Liu, Y. Ma,
J.J. Matthee, T. Nanayakkara, P.A. Oesch, R. Pan, S.H. Price, J.S. Spilker, B.
Wang, J.R. Weaver, K.E. Whitaker, C.C. Williams, A. Zitrin, The Astrophysical
Journal 996 (2026).
date_created: 2026-04-12T22:01:50Z
date_published: 2026-01-10T00:00:00Z
date_updated: 2026-05-04T11:20:42Z
day: '10'
ddc:
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department:
- _id: JoMa
doi: 10.3847/1538-4357/ae1836
external_id:
arxiv:
- '2509.05434'
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grant_number: '101076224'
name: Young galaxies as tracers and agents of cosmic reionization
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
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publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
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title: 'What you see is what you get: Empirically measured bolometric luminosities
of Little Red Dots'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 996
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...
---
OA_place: publisher
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abstract:
- lang: eng
text: Male germline development in plants is highly sensitive to heat stress, with
elevated temperatures frequently impairing male fertility and consequently reducing
seed production. Indeed, recent global warming has decreased major crop yields,
emphasizing the urgent need to elucidate the molecular and cellular mechanisms
underlying heat-induced male sterility. This review synthesizes current knowledge
on how heat stress disrupts microsporogenesis and microgametogenesis, and how
plants counteract these stresses through diverse thermotolerance mechanisms. We
emphasize temperature-sensitive processes, including meiotic progression in male
germ cells, programmed cell death of somatic tapetal nurse cells, and post-meiotic
pollen tube development. We further discuss how epigenetic regulators enhance
thermotolerance by reprogramming DNA methylation landscapes and modulating histone
variant distribution. Finally, we propose future directions aimed at understanding
the mechanisms of reproductive thermotolerance from the epigenetic perspective.
acknowledgement: This work was supported by JSPS KAKENHI (grant number JP22J01430)
and the Osamu Hayaishi Memorial Scholarship for Study Abroad for H.N.
article_number: '102881'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Hiroki
full_name: Nagai, Hiroki
id: 608df3e6-e2ab-11ed-8890-c9318cec7da4
last_name: Nagai
orcid: 0000-0003-1671-9434
- first_name: Xiaoqi
full_name: Feng, Xiaoqi
id: e0164712-22ee-11ed-b12a-d80fcdf35958
last_name: Feng
orcid: 0000-0002-4008-1234
citation:
ama: NAGAI H, Feng X. Genetic and epigenetic mechanisms underlying male reproductive
thermotolerance. Current Opinion in Plant Biology. 2026;91(6). doi:10.1016/j.pbi.2026.102881
apa: NAGAI, H., & Feng, X. (2026). Genetic and epigenetic mechanisms underlying
male reproductive thermotolerance. Current Opinion in Plant Biology. Elsevier.
https://doi.org/10.1016/j.pbi.2026.102881
chicago: NAGAI, HIROKI, and Xiaoqi Feng. “Genetic and Epigenetic Mechanisms Underlying
Male Reproductive Thermotolerance.” Current Opinion in Plant Biology. Elsevier,
2026. https://doi.org/10.1016/j.pbi.2026.102881.
ieee: H. NAGAI and X. Feng, “Genetic and epigenetic mechanisms underlying male reproductive
thermotolerance,” Current Opinion in Plant Biology, vol. 91, no. 6. Elsevier,
2026.
ista: NAGAI H, Feng X. 2026. Genetic and epigenetic mechanisms underlying male reproductive
thermotolerance. Current Opinion in Plant Biology. 91(6), 102881.
mla: NAGAI, HIROKI, and Xiaoqi Feng. “Genetic and Epigenetic Mechanisms Underlying
Male Reproductive Thermotolerance.” Current Opinion in Plant Biology, vol.
91, no. 6, 102881, Elsevier, 2026, doi:10.1016/j.pbi.2026.102881.
short: H. NAGAI, X. Feng, Current Opinion in Plant Biology 91 (2026).
corr_author: '1'
date_created: 2026-04-12T22:01:50Z
date_published: 2026-04-01T00:00:00Z
date_updated: 2026-05-04T11:15:57Z
day: '01'
ddc:
- '580'
department:
- _id: XiFe
doi: 10.1016/j.pbi.2026.102881
has_accepted_license: '1'
intvolume: ' 91'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.pbi.2026.102881
month: '04'
oa: 1
oa_version: Published Version
publication: Current Opinion in Plant Biology
publication_identifier:
eissn:
- 1879-0356
issn:
- 1369-5266
publication_status: epub_ahead
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genetic and epigenetic mechanisms underlying male reproductive thermotolerance
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 91
year: '2026'
...