---
OA_place: publisher
OA_type: hybrid
_id: '22511'
abstract:
- lang: eng
  text: Wildfires are increasing in frequency, intensity, and extent globally due
    to climate change and they can alter forest composition, structure, and function.
    The destruction and subsequent regrowth of young vegetation can modify the ecosystem
    evapotranspiration and downstream water availability. However, the response of
    forest recovery on hydrology is not well known with even the sign of evapotranspiration
    and water yield changes following forest fires being uncertain across the globe.
    Here, we quantify the effects of forest regrowth after catastrophic wildfires
    on evapotranspiration and runoff in the world's tallest angiosperm forest (Eucalyptus
    regnans) in Australia. We combine eddy covariance measurements including pre-
    and post-fire periods, mechanistic ecohydrological modeling and then extend the
    analysis spatially to multiple fires in eucalypt-dominated forests in south-eastern
    Australia by utilizing remote sensing. We find a fast recovery of evapotranspiration
    which reaches and exceeds pre-fire values within 2 years after the bushfire, a
    result confirmed by eddy covariance data, remote sensing, and modeling. Such a
    fast evapotranspiration recovery is likely generalizable to tall eucalypt forests
    in south-eastern Australia as shown by remote sensing. Once climate variability
    is discounted, ecohydrological modeling shows evapotranspiration rates from the
    recovering forest which reach peak values of +20% evapotranspiration 3 years post-fire.
    As a result, modeled runoff decreases substantially. Contrary to previous research,
    we find that the increase in modeled evapotranspiration is largely caused by the
    aerodynamic effects of a much shorter forest height leading to higher surface
    temperature, higher humidity gradients and therefore increased transpiration.
    However, increases in evapotranspiration as well as decreases in runoff caused
    by the young forest are constrained by energy and water limitations. Our result
    of an increase in evapotranspiration due to aerodynamic warming in a shorter forest
    after wildfires could occur in many parts of the world experiencing forest disturbances.
article_number: e16995
article_processing_charge: No
article_type: original
author:
- first_name: Naika
  full_name: Meili, Naika
  last_name: Meili
- first_name: Jason
  full_name: Beringer, Jason
  last_name: Beringer
- first_name: Jiacheng
  full_name: Zhao, Jiacheng
  last_name: Zhao
- first_name: Simone
  full_name: Fatichi, Simone
  id: cf8e546b-a9b0-11f0-a43b-aa89ed1b56d6
  last_name: Fatichi
citation:
  ama: Meili N, Beringer J, Zhao J, Fatichi S. Aerodynamic effects cause higher forest
    evapotranspiration and water yield reductions after wildfires in tall forests.
    <i>Global Change Biology</i>. 2024;30(1). doi:<a href="https://doi.org/10.1111/gcb.16995">10.1111/gcb.16995</a>
  apa: Meili, N., Beringer, J., Zhao, J., &#38; Fatichi, S. (2024). Aerodynamic effects
    cause higher forest evapotranspiration and water yield reductions after wildfires
    in tall forests. <i>Global Change Biology</i>. Wiley. <a href="https://doi.org/10.1111/gcb.16995">https://doi.org/10.1111/gcb.16995</a>
  chicago: Meili, Naika, Jason Beringer, Jiacheng Zhao, and Simone Fatichi. “Aerodynamic
    Effects Cause Higher Forest Evapotranspiration and Water Yield Reductions after
    Wildfires in Tall Forests.” <i>Global Change Biology</i>. Wiley, 2024. <a href="https://doi.org/10.1111/gcb.16995">https://doi.org/10.1111/gcb.16995</a>.
  ieee: N. Meili, J. Beringer, J. Zhao, and S. Fatichi, “Aerodynamic effects cause
    higher forest evapotranspiration and water yield reductions after wildfires in
    tall forests,” <i>Global Change Biology</i>, vol. 30, no. 1. Wiley, 2024.
  ista: Meili N, Beringer J, Zhao J, Fatichi S. 2024. Aerodynamic effects cause higher
    forest evapotranspiration and water yield reductions after wildfires in tall forests.
    Global Change Biology. 30(1), e16995.
  mla: Meili, Naika, et al. “Aerodynamic Effects Cause Higher Forest Evapotranspiration
    and Water Yield Reductions after Wildfires in Tall Forests.” <i>Global Change
    Biology</i>, vol. 30, no. 1, e16995, Wiley, 2024, doi:<a href="https://doi.org/10.1111/gcb.16995">10.1111/gcb.16995</a>.
  short: N. Meili, J. Beringer, J. Zhao, S. Fatichi, Global Change Biology 30 (2024).
das_tickbox: '1'
date_created: 2026-07-27T12:30:24Z
date_published: 2024-01-01T00:00:00Z
date_updated: 2026-08-11T05:51:07Z
day: '01'
doi: 10.1111/gcb.16995
extern: '1'
external_id:
  pmid:
  - '37916642'
fulldoi: https://doi.org/10.1111/gcb.16995
intvolume: '        30'
issue: '1'
keyword:
- Aerodynamic effects
- Bushfires Australia
- Ecohydrological modeling
- Eddy covariancemeasurements
- Eucalyptus regnans
- Forest evapotranspiration
- Forest recovery
- Mountain Ash
- TERN OzFlux
- Wildfires
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1111/gcb.16995
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
publication: Global Change Biology
publication_identifier:
  eissn:
  - 1365-2486
  issn:
  - 1354-1013
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Aerodynamic effects cause higher forest evapotranspiration and water yield
  reductions after wildfires in tall forests
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 30
year: '2024'
...
---
OA_place: publisher
OA_type: hybrid
_id: '22563'
abstract:
- lang: eng
  text: The ascent of water from the soil to the leaves of vascular plants, described
    by the study of plant hydraulics, regulates ecosystem responses to environmental
    forcing and recovery from stress periods. Several approaches to model plant hydraulics
    have been proposed. In this study, we introduce four different versions of plant
    hydraulics representations in the terrestrial biosphere model T&C to understand
    the significance of plant hydraulics to ecosystem functioning. We tested representations
    of plant hydraulics, investigating plant water capacitance, and long-term xylem
    damages following drought. The four models we tested were a combination of representations
    including or neglecting capacitance and including or neglecting xylem damage legacies.
    Using the models at six case studies spanning semiarid to tropical ecosystems,
    we quantify how plant xylem flow, plant water storage and long-term xylem damage
    can modulate overall water and carbon dynamics across multiple time scales. We
    show that as drought develops, models with plant hydraulics predict a slower onset
    of plant water stress, and a diurnal variability of water and carbon fluxes closer
    to observations. Plant water storage was found to be particularly important for
    the diurnal dynamics of water and carbon fluxes, with models that include plant
    water capacitance yielding better results. Models including permanent damage to
    conducting plant tissues show an additional significant drought legacy effect,
    limiting plant productivity during the recovery phase following major droughts.
    However, when considering ecosystem responses to the observed climate variability,
    plant hydraulic modules alone cannot significantly improve the overall model performance,
    even though they reproduce more realistic water and carbon dynamics. This opens
    new avenues for model development, explicitly linking plant hydraulics with additional
    ecosystem processes, such as plant phenology and improved carbon allocation algorithms.
article_number: e17022
article_processing_charge: No
article_type: original
author:
- first_name: Athanasios
  full_name: Paschalis, Athanasios
  last_name: Paschalis
- first_name: Martin G.
  full_name: De Kauwe, Martin G.
  last_name: De Kauwe
- first_name: Manon
  full_name: Sabot, Manon
  last_name: Sabot
- first_name: Simone
  full_name: Fatichi, Simone
  id: cf8e546b-a9b0-11f0-a43b-aa89ed1b56d6
  last_name: Fatichi
citation:
  ama: Paschalis A, De Kauwe MG, Sabot M, Fatichi S. When do plant hydraulics matter
    in terrestrial biosphere modelling? <i>Global Change Biology</i>. 2024;30(1).
    doi:<a href="https://doi.org/10.1111/gcb.17022">10.1111/gcb.17022</a>
  apa: Paschalis, A., De Kauwe, M. G., Sabot, M., &#38; Fatichi, S. (2024). When do
    plant hydraulics matter in terrestrial biosphere modelling? <i>Global Change Biology</i>.
    Wiley. <a href="https://doi.org/10.1111/gcb.17022">https://doi.org/10.1111/gcb.17022</a>
  chicago: Paschalis, Athanasios, Martin G. De Kauwe, Manon Sabot, and Simone Fatichi.
    “When Do Plant Hydraulics Matter in Terrestrial Biosphere Modelling?” <i>Global
    Change Biology</i>. Wiley, 2024. <a href="https://doi.org/10.1111/gcb.17022">https://doi.org/10.1111/gcb.17022</a>.
  ieee: A. Paschalis, M. G. De Kauwe, M. Sabot, and S. Fatichi, “When do plant hydraulics
    matter in terrestrial biosphere modelling?,” <i>Global Change Biology</i>, vol.
    30, no. 1. Wiley, 2024.
  ista: Paschalis A, De Kauwe MG, Sabot M, Fatichi S. 2024. When do plant hydraulics
    matter in terrestrial biosphere modelling? Global Change Biology. 30(1), e17022.
  mla: Paschalis, Athanasios, et al. “When Do Plant Hydraulics Matter in Terrestrial
    Biosphere Modelling?” <i>Global Change Biology</i>, vol. 30, no. 1, e17022, Wiley,
    2024, doi:<a href="https://doi.org/10.1111/gcb.17022">10.1111/gcb.17022</a>.
  short: A. Paschalis, M.G. De Kauwe, M. Sabot, S. Fatichi, Global Change Biology
    30 (2024).
das_tickbox: '1'
date_created: 2026-07-27T12:30:24Z
date_published: 2024-01-01T00:00:00Z
date_updated: 2026-08-12T08:44:53Z
day: '01'
doi: 10.1111/gcb.17022
extern: '1'
external_id:
  pmid:
  - '37962234 '
fulldoi: https://doi.org/10.1111/gcb.17022
intvolume: '        30'
issue: '1'
keyword:
- Ecosystem recovery
- Ecosystem responses
- Plant hydraulics
- Terrestrial biosphere model
- Water stress
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: ' https://doi.org/10.1111/gcb.17022'
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
publication: Global Change Biology
publication_identifier:
  eissn:
  - 1365-2486
  issn:
  - 1354-1013
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: When do plant hydraulics matter in terrestrial biosphere modelling?
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 30
year: '2024'
...
---
OA_place: publisher
OA_type: hybrid
_id: '22583'
abstract:
- lang: eng
  text: Accurately predicting weather and climate in cities is critical for safeguarding
    human health and strengthening urban resilience. Multimodel evaluations can lead
    to model improvements; however, there have been no major intercomparisons of urban-focussed
    land surface models in over a decade. Here, in Phase 1 of the Urban-PLUMBER project,
    we evaluate the ability of 30 land surface models to simulate surface energy fluxes
    critical to atmospheric meteorological and air quality simulations. We establish
    minimum and upper performance expectations for participating models using simple
    information-limited models as benchmarks. Compared with the last major model intercomparison
    at the same site, we find broad improvement in the current cohort's predictions
    of short-wave radiation, sensible and latent heat fluxes, but little or no improvement
    in long-wave radiation and momentum fluxes. Models with a simple urban representation
    (e.g., ‘slab’ schemes) generally perform well, particularly when combined with
    sophisticated hydrological/vegetation models. Some mid-complexity models (e.g.,
    ‘canyon’ schemes) also perform well, indicating efforts to integrate vegetation
    and hydrology processes have paid dividends. The most complex models that resolve
    three-dimensional interactions between buildings in general did not perform as
    well as other categories. However, these models also tended to have the simplest
    representations of hydrology and vegetation. Models without any urban representation
    (i.e., vegetation-only land surface models) performed poorly for latent heat fluxes,
    and reasonably for other energy fluxes at this suburban site. Our analysis identified
    widespread human errors in initial submissions that substantially affected model
    performances. Although significant efforts are applied to correct these errors,
    we conclude that human factors are likely to influence results in this (or any)
    model intercomparison, particularly where participating scientists have varying
    experience and first languages. These initial results are for one suburban site,
    and future phases of Urban-PLUMBER will evaluate models across 20 sites in different
    urban and regional climate zones.
article_processing_charge: No
article_type: original
author:
- first_name: Mathew J.
  full_name: Lipson, Mathew J.
  last_name: Lipson
- first_name: Sue
  full_name: Grimmond, Sue
  last_name: Grimmond
- first_name: Martin
  full_name: Best, Martin
  last_name: Best
- first_name: Gab
  full_name: Abramowitz, Gab
  last_name: Abramowitz
- first_name: Andrew
  full_name: Coutts, Andrew
  last_name: Coutts
- first_name: Nigel
  full_name: Tapper, Nigel
  last_name: Tapper
- first_name: Jong‐Jin
  full_name: Baik, Jong‐Jin
  last_name: Baik
- first_name: Meiring
  full_name: Beyers, Meiring
  last_name: Beyers
- first_name: Lewis
  full_name: Blunn, Lewis
  last_name: Blunn
- first_name: Souhail
  full_name: Boussetta, Souhail
  last_name: Boussetta
- first_name: Elie
  full_name: Bou‐Zeid, Elie
  last_name: Bou‐Zeid
- first_name: Martin G.
  full_name: De Kauwe, Martin G.
  last_name: De Kauwe
- first_name: Cécile
  full_name: de Munck, Cécile
  last_name: de Munck
- first_name: Matthias
  full_name: Demuzere, Matthias
  last_name: Demuzere
- first_name: Simone
  full_name: Fatichi, Simone
  id: cf8e546b-a9b0-11f0-a43b-aa89ed1b56d6
  last_name: Fatichi
- first_name: Krzysztof
  full_name: Fortuniak, Krzysztof
  last_name: Fortuniak
- first_name: Beom‐Soon
  full_name: Han, Beom‐Soon
  last_name: Han
- first_name: Margaret A.
  full_name: Hendry, Margaret A.
  last_name: Hendry
- first_name: Yukihiro
  full_name: Kikegawa, Yukihiro
  last_name: Kikegawa
- first_name: Hiroaki
  full_name: Kondo, Hiroaki
  last_name: Kondo
- first_name: Doo‐Il
  full_name: Lee, Doo‐Il
  last_name: Lee
- first_name: Sang‐Hyun
  full_name: Lee, Sang‐Hyun
  last_name: Lee
- first_name: Aude
  full_name: Lemonsu, Aude
  last_name: Lemonsu
- first_name: Tiago
  full_name: Machado, Tiago
  last_name: Machado
- first_name: Gabriele
  full_name: Manoli, Gabriele
  last_name: Manoli
- first_name: Alberto
  full_name: Martilli, Alberto
  last_name: Martilli
- first_name: Valéry
  full_name: Masson, Valéry
  last_name: Masson
- first_name: Joe
  full_name: McNorton, Joe
  last_name: McNorton
- first_name: Naika
  full_name: Meili, Naika
  last_name: Meili
- first_name: David
  full_name: Meyer, David
  last_name: Meyer
- first_name: Kerry A.
  full_name: Nice, Kerry A.
  last_name: Nice
- first_name: Keith W.
  full_name: Oleson, Keith W.
  last_name: Oleson
- first_name: Seung‐Bu
  full_name: Park, Seung‐Bu
  last_name: Park
- first_name: Michael
  full_name: Roth, Michael
  last_name: Roth
- first_name: Robert
  full_name: Schoetter, Robert
  last_name: Schoetter
- first_name: Andrés
  full_name: Simón‐Moral, Andrés
  last_name: Simón‐Moral
- first_name: Gert‐Jan
  full_name: Steeneveld, Gert‐Jan
  last_name: Steeneveld
- first_name: Ting
  full_name: Sun, Ting
  last_name: Sun
- first_name: Yuya
  full_name: Takane, Yuya
  last_name: Takane
- first_name: Marcus
  full_name: Thatcher, Marcus
  last_name: Thatcher
- first_name: Aristofanis
  full_name: Tsiringakis, Aristofanis
  last_name: Tsiringakis
- first_name: Mikhail
  full_name: Varentsov, Mikhail
  last_name: Varentsov
- first_name: Chenghao
  full_name: Wang, Chenghao
  last_name: Wang
- first_name: Zhi‐Hua
  full_name: Wang, Zhi‐Hua
  last_name: Wang
- first_name: Andy J.
  full_name: Pitman, Andy J.
  last_name: Pitman
citation:
  ama: 'Lipson MJ, Grimmond S, Best M, et al. Evaluation of 30 urban land surface
    models in the Urban-PLUMBER project: Phase 1 results. <i>Quarterly Journal of
    the Royal Meteorological Society</i>. 2024;150(758):126-169. doi:<a href="https://doi.org/10.1002/qj.4589">10.1002/qj.4589</a>'
  apa: 'Lipson, M. J., Grimmond, S., Best, M., Abramowitz, G., Coutts, A., Tapper,
    N., … Pitman, A. J. (2024). Evaluation of 30 urban land surface models in the
    Urban-PLUMBER project: Phase 1 results. <i>Quarterly Journal of the Royal Meteorological
    Society</i>. Wiley. <a href="https://doi.org/10.1002/qj.4589">https://doi.org/10.1002/qj.4589</a>'
  chicago: 'Lipson, Mathew J., Sue Grimmond, Martin Best, Gab Abramowitz, Andrew Coutts,
    Nigel Tapper, Jong‐Jin Baik, et al. “Evaluation of 30 Urban Land Surface Models
    in the Urban-PLUMBER Project: Phase 1 Results.” <i>Quarterly Journal of the Royal
    Meteorological Society</i>. Wiley, 2024. <a href="https://doi.org/10.1002/qj.4589">https://doi.org/10.1002/qj.4589</a>.'
  ieee: 'M. J. Lipson <i>et al.</i>, “Evaluation of 30 urban land surface models in
    the Urban-PLUMBER project: Phase 1 results,” <i>Quarterly Journal of the Royal
    Meteorological Society</i>, vol. 150, no. 758. Wiley, pp. 126–169, 2024.'
  ista: 'Lipson MJ, Grimmond S, Best M, Abramowitz G, Coutts A, Tapper N, Baik J,
    Beyers M, Blunn L, Boussetta S, Bou‐Zeid E, De Kauwe MG, de Munck C, Demuzere
    M, Fatichi S, Fortuniak K, Han B, Hendry MA, Kikegawa Y, Kondo H, Lee D, Lee S,
    Lemonsu A, Machado T, Manoli G, Martilli A, Masson V, McNorton J, Meili N, Meyer
    D, Nice KA, Oleson KW, Park S, Roth M, Schoetter R, Simón‐Moral A, Steeneveld
    G, Sun T, Takane Y, Thatcher M, Tsiringakis A, Varentsov M, Wang C, Wang Z, Pitman
    AJ. 2024. Evaluation of 30 urban land surface models in the Urban-PLUMBER project:
    Phase 1 results. Quarterly Journal of the Royal Meteorological Society. 150(758),
    126–169.'
  mla: 'Lipson, Mathew J., et al. “Evaluation of 30 Urban Land Surface Models in the
    Urban-PLUMBER Project: Phase 1 Results.” <i>Quarterly Journal of the Royal Meteorological
    Society</i>, vol. 150, no. 758, Wiley, 2024, pp. 126–69, doi:<a href="https://doi.org/10.1002/qj.4589">10.1002/qj.4589</a>.'
  short: M.J. Lipson, S. Grimmond, M. Best, G. Abramowitz, A. Coutts, N. Tapper, J.
    Baik, M. Beyers, L. Blunn, S. Boussetta, E. Bou‐Zeid, M.G. De Kauwe, C. de Munck,
    M. Demuzere, S. Fatichi, K. Fortuniak, B. Han, M.A. Hendry, Y. Kikegawa, H. Kondo,
    D. Lee, S. Lee, A. Lemonsu, T. Machado, G. Manoli, A. Martilli, V. Masson, J.
    McNorton, N. Meili, D. Meyer, K.A. Nice, K.W. Oleson, S. Park, M. Roth, R. Schoetter,
    A. Simón‐Moral, G. Steeneveld, T. Sun, Y. Takane, M. Thatcher, A. Tsiringakis,
    M. Varentsov, C. Wang, Z. Wang, A.J. Pitman, Quarterly Journal of the Royal Meteorological
    Society 150 (2024) 126–169.
das_tickbox: '1'
date_created: 2026-07-27T12:30:25Z
date_published: 2024-01-01T00:00:00Z
date_updated: 2026-08-12T08:53:18Z
day: '01'
doi: 10.1002/qj.4589
extern: '1'
fulldoi: https://doi.org/10.1002/qj.4589
intvolume: '       150'
issue: '758'
keyword:
- Benchmark
- Energy balance
- Intercomparison
- Model evaluation
- Urban climate
- Urban meteorology
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1002/qj.4589
month: '01'
oa: 1
oa_version: Published Version
page: 126-169
publication: Quarterly Journal of the Royal Meteorological Society
publication_identifier:
  eissn:
  - 1477-870X
  issn:
  - 0035-9009
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Evaluation of 30 urban land surface models in the Urban-PLUMBER project: Phase
  1 results'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 150
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '22234'
abstract:
- lang: eng
  text: Lists of nontrivial integral points on some (families of) cubic surfaces.
    (2024-07-18)
article_processing_charge: No
author:
- first_name: Timothy D
  full_name: Browning, Timothy D
  id: 35827D50-F248-11E8-B48F-1D18A9856A87
  last_name: Browning
  orcid: 0000-0002-8314-0177
- first_name: Andrew
  full_name: Sutherland, Andrew
  last_name: Sutherland
citation:
  ama: 'Browning TD, Sutherland A. Data and code for: Integral points on cubic surfaces:
    heuristics and numerics. 2024. doi:<a href="https://doi.org/10.25625/4FLFH8">10.25625/4FLFH8</a>'
  apa: 'Browning, T. D., &#38; Sutherland, A. (2024). Data and code for: Integral
    points on cubic surfaces: heuristics and numerics. Göttingen Research Online Data.
    <a href="https://doi.org/10.25625/4FLFH8">https://doi.org/10.25625/4FLFH8</a>'
  chicago: 'Browning, Timothy D, and Andrew Sutherland. “Data and Code for: Integral
    Points on Cubic Surfaces: Heuristics and Numerics.” Göttingen Research Online
    Data, 2024. <a href="https://doi.org/10.25625/4FLFH8">https://doi.org/10.25625/4FLFH8</a>.'
  ieee: 'T. D. Browning and A. Sutherland, “Data and code for: Integral points on
    cubic surfaces: heuristics and numerics.” Göttingen Research Online Data, 2024.'
  ista: 'Browning TD, Sutherland A. 2024. Data and code for: Integral points on cubic
    surfaces: heuristics and numerics, Göttingen Research Online Data, <a href="https://doi.org/10.25625/4FLFH8">10.25625/4FLFH8</a>.'
  mla: 'Browning, Timothy D., and Andrew Sutherland. <i>Data and Code for: Integral
    Points on Cubic Surfaces: Heuristics and Numerics</i>. Göttingen Research Online
    Data, 2024, doi:<a href="https://doi.org/10.25625/4FLFH8">10.25625/4FLFH8</a>.'
  short: T.D. Browning, A. Sutherland, (2024).
contributor:
- first_name: Florian Alexander
  id: 560601DA-8D36-11E9-A136-7AC1E5697425
  last_name: Wilsch
  orcid: 0000-0001-7302-8256
corr_author: '1'
date_created: 2026-07-02T10:38:53Z
date_published: 2024-07-22T00:00:00Z
date_updated: 2026-08-12T12:15:33Z
day: '22'
ddc:
- '500'
department:
- _id: TiBr
doi: 10.25625/4FLFH8
fulldoi: https://doi.org/10.25625/4FLFH8
has_accepted_license: '1'
main_file_link:
- open_access: '1'
  url: https://doi.org/10.25625/4FLFH8
month: '07'
oa: 1
oa_version: Published Version
publisher: Göttingen Research Online Data
related_material:
  record:
  - id: '20249'
    relation: used_in_publication
    status: public
status: public
title: 'Data and code for: Integral points on cubic surfaces: heuristics and numerics'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '19063'
abstract:
- lang: eng
  text: "Instruction-tuned Large Language Models (LLMs) show impressive results in
    numerous practical applications, but they lack essential safety features that
    are common in other areas of computer science, particularly an explicit separation
    of instructions and data. This makes them vulnerable to manipulations such as
    indirect prompt injections and generally unsuitable for safety-critical tasks.
    Surprisingly, there is currently no established definition or benchmark to quantify
    this phenomenon. In this work, we close this gap by introducing a formal measure
    for instruction-data separation and an empirical variant that is calculable from
    a model's outputs. We also present a new dataset, SEP, that allows estimating
    the measure for real-world models. Our results on various LLMs show that the problem
    of instruction-data separation is real: all models fail to achieve high separation,
    and canonical mitigation techniques, such as prompt engineering and fine-tuning,
    either fail to substantially improve separation or reduce model utility. The source
    code and SEP dataset are openly accessible at https://github.com/egozverev/Shold-It-Be-Executed-Or-Processed.\r\n"
acknowledged_ssus:
- _id: ScienComp
acknowledgement: The authors would like to sincerely thank Juan Rocamonde for valuable
  feedback to our manuscript. We acknowledge the support from the Scientific Service
  Units (SSU) of ISTA through resources provided by Scientific Computing (SciComp).
  We thank Dan Alistarh for providing us with computational resources. This work was
  partially funded by the German Federal Ministry of Education and Research (BMBF)
  under the grant AIgenCY (16KIS2012) and ELSA – European Lighthouse on Secure and
  Safe AI funded by the European Union under grant agreement No. 101070617. Views
  and opinions expressed are however those of the authors only and do not necessarily
  reflect those of the European Union or European Commission. Neither the European
  Union nor the European Commission can be held responsible for them.
article_number: '2403.06833'
article_processing_charge: No
arxiv: 1
author:
- first_name: Egor
  full_name: Zverev, Egor
  id: 05162b19-1340-11ed-8f02-fa94e0e8c3bc
  last_name: Zverev
- first_name: Sahar
  full_name: Abdelnabi, Sahar
  last_name: Abdelnabi
- first_name: Soroush
  full_name: Tabesh, Soroush
  id: 06000900-6068-11ef-8d61-c2472ef2e752
  last_name: Tabesh
  orcid: 0009-0003-4119-6281
- first_name: Mario
  full_name: Fritz, Mario
  last_name: Fritz
- first_name: Christoph
  full_name: Lampert, Christoph
  id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
  last_name: Lampert
  orcid: 0000-0001-8622-7887
citation:
  ama: Zverev E, Abdelnabi S, Tabesh S, Fritz M, Lampert C. Can LLMs separate instructions
    from data? And what do we even mean by that? <i>arXiv</i>. doi:<a href="https://doi.org/10.48550/arXiv.2403.06833">10.48550/arXiv.2403.06833</a>
  apa: Zverev, E., Abdelnabi, S., Tabesh, S., Fritz, M., &#38; Lampert, C. (n.d.).
    Can LLMs separate instructions from data? And what do we even mean by that? <i>arXiv</i>.
    <a href="https://doi.org/10.48550/arXiv.2403.06833">https://doi.org/10.48550/arXiv.2403.06833</a>
  chicago: Zverev, Egor, Sahar Abdelnabi, Soroush Tabesh, Mario Fritz, and Christoph
    Lampert. “Can LLMs Separate Instructions from Data? And What Do We Even Mean by
    That?” <i>ArXiv</i>, n.d. <a href="https://doi.org/10.48550/arXiv.2403.06833">https://doi.org/10.48550/arXiv.2403.06833</a>.
  ieee: E. Zverev, S. Abdelnabi, S. Tabesh, M. Fritz, and C. Lampert, “Can LLMs separate
    instructions from data? And what do we even mean by that?,” <i>arXiv</i>. .
  ista: Zverev E, Abdelnabi S, Tabesh S, Fritz M, Lampert C. Can LLMs separate instructions
    from data? And what do we even mean by that? arXiv, 2403.06833.
  mla: Zverev, Egor, et al. “Can LLMs Separate Instructions from Data? And What Do
    We Even Mean by That?” <i>ArXiv</i>, 2403.06833, doi:<a href="https://doi.org/10.48550/arXiv.2403.06833">10.48550/arXiv.2403.06833</a>.
  short: E. Zverev, S. Abdelnabi, S. Tabesh, M. Fritz, C. Lampert, ArXiv (n.d.).
corr_author: '1'
date_created: 2025-02-20T10:13:42Z
date_published: 2024-03-01T00:00:00Z
date_updated: 2026-08-13T07:26:54Z
day: '01'
ddc:
- '000'
department:
- _id: GradSch
- _id: ChLa
doi: 10.48550/arXiv.2403.06833
external_id:
  arxiv:
  - '2403.06833'
file:
- access_level: open_access
  checksum: 35eb43968684b87be59144603ef10af0
  content_type: application/pdf
  creator: ezverev
  date_created: 2025-02-20T10:11:45Z
  date_updated: 2025-02-20T10:11:45Z
  file_id: '19064'
  file_name: 2403.06833v3.pdf
  file_size: 530972
  relation: main_file
  success: 1
file_date_updated: 2025-02-20T10:11:45Z
fulldoi: https://doi.org/10.48550/arXiv.2403.06833
has_accepted_license: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Preprint
publication: arXiv
publication_status: submitted
related_material:
  link:
  - relation: software
    url: ' https://github.com/egozverev/Shold-It-Be-Executed-Or-Processed'
status: public
title: Can LLMs separate instructions from data? And what do we even mean by that?
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2024'
...
---
_id: '17161'
abstract:
- lang: eng
  text: Dynamic processes in molecules can occur on a wide range of timescales, and
    it is important to understand which timescales of motion contribute to different
    parameters used in dynamics measurements. For spin relaxation, this can easily
    be understood from the sampling frequencies of the spectral-density function by
    different relaxation-rate constants. In addition to data from relaxation measurements,
    determining dynamically averaged anisotropic interactions in magic-angle spinning
    (MAS) solid-state NMR allows for better quantification of the amplitude of molecular
    motion. For partially averaged anisotropic interactions, the relevant timescales
    of motion are not so clearly defined. Whether the averaging depends on the experimental
    methods (e.g., pulse sequences) or conditions (e.g., MAS frequency, magnitude
    of anisotropic interaction, radio-frequency field amplitudes) is not fully understood.
    To investigate these questions, we performed numerical simulations of dynamic
    systems based on the stochastic Liouville equation using several experiments for
    recoupling the dipolar coupling, chemical-shift anisotropy or quadrupolar coupling.
    As described in the literature, the transition between slow motion, where parameters
    characterizing the anisotropic interaction are not averaged, and fast motion,
    where the tensors are averaged leading to a scaled anisotropic quantity, occurs
    over a window of motional rate constants that depends mainly on the strength of
    the interaction. This transition region can span 2 orders of magnitude in exchange-rate
    constants (typically in the microsecond range) but depends only marginally on
    the employed recoupling scheme or sample spinning frequency. The transition region
    often coincides with a fast relaxation of coherences, making precise quantitative
    measurements difficult. Residual couplings in off-magic-angle experiments, however,
    average over longer timescales of motion. While in principle one may gain information
    on the timescales of motion from the transition area, extracting such information
    is hampered by low signal-to-noise ratio in experimental spectra due to fast relaxation
    that occurs in the same region.
acknowledgement: "We would like to thank Kay Saalwächter for pointing out important
  aspects of the intermediate regime during the open review process. Lea Marie Becker
  is recipient of a DOC fellowship of the Austrian Academy of Sciences at the Institute
  of Science and Technology Austria.\r\nThis research has been supported by the Österreichischen
  Akademie der Wissenschaften (grant no. PR10660EAW01) and the Schweizerischer Nationalfonds
  zur Förderung der Wissenschaftlichen Forschung (grant nos. 200020_188988 and 200020_219375)."
article_processing_charge: Yes
article_type: original
author:
- first_name: Kathrin
  full_name: Aebischer, Kathrin
  last_name: Aebischer
- first_name: Lea Marie
  full_name: Becker, Lea Marie
  id: 36336939-eb97-11eb-a6c2-c83f1214ca79
  last_name: Becker
  orcid: 0000-0002-6401-5151
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
- first_name: Matthias
  full_name: Ernst, Matthias
  last_name: Ernst
citation:
  ama: Aebischer K, Becker LM, Schanda P, Ernst M. Evaluating the motional timescales
    contributing to averaged anisotropic interactions in MAS solid-state NMR. <i>Magnetic
    Resonance</i>. 2024;5(1):69-86. doi:<a href="https://doi.org/10.5194/mr-5-69-2024">10.5194/mr-5-69-2024</a>
  apa: Aebischer, K., Becker, L. M., Schanda, P., &#38; Ernst, M. (2024). Evaluating
    the motional timescales contributing to averaged anisotropic interactions in MAS
    solid-state NMR. <i>Magnetic Resonance</i>. Copernicus Publications. <a href="https://doi.org/10.5194/mr-5-69-2024">https://doi.org/10.5194/mr-5-69-2024</a>
  chicago: Aebischer, Kathrin, Lea Marie Becker, Paul Schanda, and Matthias Ernst.
    “Evaluating the Motional Timescales Contributing to Averaged Anisotropic Interactions
    in MAS Solid-State NMR.” <i>Magnetic Resonance</i>. Copernicus Publications, 2024.
    <a href="https://doi.org/10.5194/mr-5-69-2024">https://doi.org/10.5194/mr-5-69-2024</a>.
  ieee: K. Aebischer, L. M. Becker, P. Schanda, and M. Ernst, “Evaluating the motional
    timescales contributing to averaged anisotropic interactions in MAS solid-state
    NMR,” <i>Magnetic Resonance</i>, vol. 5, no. 1. Copernicus Publications, pp. 69–86,
    2024.
  ista: Aebischer K, Becker LM, Schanda P, Ernst M. 2024. Evaluating the motional
    timescales contributing to averaged anisotropic interactions in MAS solid-state
    NMR. Magnetic Resonance. 5(1), 69–86.
  mla: Aebischer, Kathrin, et al. “Evaluating the Motional Timescales Contributing
    to Averaged Anisotropic Interactions in MAS Solid-State NMR.” <i>Magnetic Resonance</i>,
    vol. 5, no. 1, Copernicus Publications, 2024, pp. 69–86, doi:<a href="https://doi.org/10.5194/mr-5-69-2024">10.5194/mr-5-69-2024</a>.
  short: K. Aebischer, L.M. Becker, P. Schanda, M. Ernst, Magnetic Resonance 5 (2024)
    69–86.
date_created: 2024-06-23T22:01:02Z
date_published: 2024-06-11T00:00:00Z
date_updated: 2026-09-11T08:49:55Z
day: '11'
ddc:
- '530'
department:
- _id: PaSc
doi: 10.5194/mr-5-69-2024
external_id:
  pmid:
  - '40384772'
file:
- access_level: open_access
  checksum: d01074f6919387fcaf8c9ebed320ccae
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  creator: dernst
  date_created: 2024-06-27T06:42:55Z
  date_updated: 2024-06-27T06:42:55Z
  file_id: '17181'
  file_name: 2024_MagneticResonance_Aebischer.pdf
  file_size: 6736194
  relation: main_file
  success: 1
file_date_updated: 2024-06-27T06:42:55Z
fulldoi: https://doi.org/10.5194/mr-5-69-2024
has_accepted_license: '1'
intvolume: '         5'
issue: '1'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 69-86
pmid: 1
project:
- _id: 7be609c4-9f16-11ee-852c-85015ce2b9b0
  grant_number: '26777'
  name: Exploring protein dynamics by solid-state MAS NMR through specific labeling
    approaches
publication: Magnetic Resonance
publication_identifier:
  eissn:
  - 2699-0016
publication_status: published
publisher: Copernicus Publications
quality_controlled: '1'
related_material:
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  - id: '22906'
    relation: research_data
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scopus_import: '1'
status: public
title: Evaluating the motional timescales contributing to averaged anisotropic interactions
  in MAS solid-state NMR
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '22906'
article_processing_charge: No
author:
- first_name: Kathrin
  full_name: Aebischer, Kathrin
  last_name: Aebischer
citation:
  ama: Aebischer K. Evaluating the motional time scales contributing to averaged anisotropic
    interactions in MAS solid-state NMR. 2024. doi:<a href="https://doi.org/10.3929/ethz-b-000666765">10.3929/ethz-b-000666765</a>
  apa: Aebischer, K. (2024). Evaluating the motional time scales contributing to averaged
    anisotropic interactions in MAS solid-state NMR. Repository. <a href="https://doi.org/10.3929/ethz-b-000666765">https://doi.org/10.3929/ethz-b-000666765</a>
  chicago: Aebischer, Kathrin. “Evaluating the Motional Time Scales Contributing to
    Averaged Anisotropic Interactions in MAS Solid-State NMR.” Repository, 2024. <a
    href="https://doi.org/10.3929/ethz-b-000666765">https://doi.org/10.3929/ethz-b-000666765</a>.
  ieee: K. Aebischer, “Evaluating the motional time scales contributing to averaged
    anisotropic interactions in MAS solid-state NMR.” Repository, 2024.
  ista: Aebischer K. 2024. Evaluating the motional time scales contributing to averaged
    anisotropic interactions in MAS solid-state NMR, Repository, <a href="https://doi.org/10.3929/ethz-b-000666765">10.3929/ethz-b-000666765</a>.
  mla: Aebischer, Kathrin. <i>Evaluating the Motional Time Scales Contributing to
    Averaged Anisotropic Interactions in MAS Solid-State NMR</i>. Repository, 2024,
    doi:<a href="https://doi.org/10.3929/ethz-b-000666765">10.3929/ethz-b-000666765</a>.
  short: K. Aebischer, (2024).
contributor:
- contributor_type: contact_person
  first_name: Matthias
  last_name: Ernst
- contributor_type: data_collector
  first_name: Kathrin
  last_name: Aebischer
- contributor_type: data_collector
  first_name: Matthias
  last_name: Ernst
- contributor_type: data_collector
  first_name: Paul
  last_name: Schanda
- contributor_type: data_collector
  first_name: Lea Marie
  last_name: Becker
- contributor_type: producer
  first_name: Matthias
  last_name: ' Ernst'
- contributor_type: producer
  first_name: Kathrin
  last_name: ' Aebischer'
- contributor_type: producer
  first_name: 'Paul '
  last_name: Schanda
- contributor_type: producer
  first_name: Lea Marie
  last_name: Becker
date_created: 2026-09-11T08:49:48Z
date_published: 2024-04-03T00:00:00Z
date_updated: 2026-09-11T08:49:55Z
day: '03'
ddc:
- '530'
department:
- _id: PaSc
doi: 10.3929/ethz-b-000666765
fulldoi: https://doi.org/10.3929/ethz-b-000666765
main_file_link:
- open_access: '1'
  url: https://doi.org/10.3929/ethz-b-000666765
month: '04'
oa: 1
oa_version: None
publisher: Repository
related_material:
  record:
  - id: '17161'
    relation: used_in_publication
    status: public
status: public
title: Evaluating the motional time scales contributing to averaged anisotropic interactions
  in MAS solid-state NMR
type: research_data_reference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
year: '2024'
...
---
APC_amount: 6248,82 EUR
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '18603'
abstract:
- lang: eng
  text: It is widely believed that information storage in neuronal circuits involves
    nanoscopic structural changes at synapses, resulting in the formation of synaptic
    engrams. However, direct evidence for this hypothesis is lacking. To test this
    conjecture, we combined chemical potentiation, functional analysis by paired pre-postsynaptic
    recordings, and structural analysis by electron microscopy (EM) and freeze-fracture
    replica labeling (FRL) at the rodent hippocampal mossy fiber synapse, a key synapse
    in the trisynaptic circuit of the hippocampus. Biophysical analysis of synaptic
    transmission revealed that forskolin-induced chemical potentiation increased the
    readily releasable vesicle pool size and vesicular release probability by 146%
    and 49%, respectively. Structural analysis of mossy fiber synapses by EM and FRL
    demonstrated an increase in the number of vesicles close to the plasma membrane
    and the number of clusters of the priming protein Munc13-1, indicating an increase
    in the number of both docked and primed vesicles. Furthermore, FRL analysis revealed
    a significant reduction of the distance between Munc13-1 and CaV2.1 Ca2+ channels,
    suggesting reconfiguration of the channel-vesicle coupling nanotopography. Our
    results indicate that presynaptic plasticity is associated with structural reorganization
    of active zones. We propose that changes in potential nanoscopic organization
    at synaptic vesicle release sites may be correlates of learning and memory at
    a plastic central synapse.
acknowledged_ssus:
- _id: EM-Fac
- _id: PreCl
acknowledgement: "We thank Carolina Borges-Merjane, Jing-Jing Chen, Katharina Lichter,
  and Samuel Young for critically reading the manuscript; the Electron Microscopy
  Facility of ISTA, in particular Vanessa Zheden, for extensive support, advice, and
  experimental assistance; the Preclinical Facility of ISTA, in particular Victoria
  Wimmer and Michael Schunn, for experimental assistance; Florian Marr and Christina
  Altmutter for technical support; Alois Schlögl for help with analysis; and Eleftheria
  Kralli-Beller for manuscript editing. We also thank Cordelia Imig for providing
  Munc13-1cKO-Munc13-2/3(−/−) mutant mice. Part of the work has been published in
  O.K.’s thesis in partial fulfillment of the requirements for the degree of Doctor
  of Philosophy.\r\nThis project received funding from the European Research Council
  and European Union’s Horizon 2020 research and innovation programme (ERC 692692
  to P.J.; https://cordis.europa.eu/project/id/692692/de) and from the Fond zur Förderung
  der Wissenschaftlichen Forschung (Z312-B27 Wittgenstein award to P.J., https://www.fwf.ac.at/en/funding/portfolio/projects/fwf-wittgenstein-award;
  W1205-B09 and P36232-B to P.J., https://www.fwf.ac.at/en/funding; I6166-B to R.S.;
  https://www.fwf.ac.at/en/funding). The funders had no role in study design, data
  collection and analysis, decision to publish, or preparation of the manuscript."
article_number: e3002879
article_processing_charge: Yes
article_type: original
author:
- first_name: Olena
  full_name: Kim, Olena
  id: 3F8ABDDA-F248-11E8-B48F-1D18A9856A87
  last_name: Kim
  orcid: 0000-0003-2344-1039
- first_name: Yuji
  full_name: Okamoto, Yuji
  id: 3337E116-F248-11E8-B48F-1D18A9856A87
  last_name: Okamoto
  orcid: 0000-0003-0408-6094
- first_name: Walter
  full_name: Kaufmann, Walter
  id: 3F99E422-F248-11E8-B48F-1D18A9856A87
  last_name: Kaufmann
  orcid: 0000-0001-9735-5315
- first_name: Nils
  full_name: Brose, Nils
  last_name: Brose
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Kim O, Okamoto Y, Kaufmann W, Brose N, Shigemoto R, Jonas PM. Presynaptic cAMP-PKA-mediated
    potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle
    coupling at hippocampal mossy fiber boutons. <i>PLoS Biology</i>. 2024;22(11).
    doi:<a href="https://doi.org/10.1371/journal.pbio.3002879">10.1371/journal.pbio.3002879</a>
  apa: Kim, O., Okamoto, Y., Kaufmann, W., Brose, N., Shigemoto, R., &#38; Jonas,
    P. M. (2024). Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration
    of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber
    boutons. <i>PLoS Biology</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pbio.3002879">https://doi.org/10.1371/journal.pbio.3002879</a>
  chicago: Kim, Olena, Yuji Okamoto, Walter Kaufmann, Nils Brose, Ryuichi Shigemoto,
    and Peter M Jonas. “Presynaptic CAMP-PKA-Mediated Potentiation Induces Reconfiguration
    of Synaptic Vesicle Pools and Channel-Vesicle Coupling at Hippocampal Mossy Fiber
    Boutons.” <i>PLoS Biology</i>. Public Library of Science, 2024. <a href="https://doi.org/10.1371/journal.pbio.3002879">https://doi.org/10.1371/journal.pbio.3002879</a>.
  ieee: O. Kim, Y. Okamoto, W. Kaufmann, N. Brose, R. Shigemoto, and P. M. Jonas,
    “Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic
    vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons,”
    <i>PLoS Biology</i>, vol. 22, no. 11. Public Library of Science, 2024.
  ista: Kim O, Okamoto Y, Kaufmann W, Brose N, Shigemoto R, Jonas PM. 2024. Presynaptic
    cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools
    and channel-vesicle coupling at hippocampal mossy fiber boutons. PLoS Biology.
    22(11), e3002879.
  mla: Kim, Olena, et al. “Presynaptic CAMP-PKA-Mediated Potentiation Induces Reconfiguration
    of Synaptic Vesicle Pools and Channel-Vesicle Coupling at Hippocampal Mossy Fiber
    Boutons.” <i>PLoS Biology</i>, vol. 22, no. 11, e3002879, Public Library of Science,
    2024, doi:<a href="https://doi.org/10.1371/journal.pbio.3002879">10.1371/journal.pbio.3002879</a>.
  short: O. Kim, Y. Okamoto, W. Kaufmann, N. Brose, R. Shigemoto, P.M. Jonas, PLoS
    Biology 22 (2024).
corr_author: '1'
date_created: 2024-12-01T23:01:54Z
date_published: 2024-11-18T00:00:00Z
date_updated: 2026-04-16T12:20:34Z
day: '18'
ddc:
- '570'
department:
- _id: PeJo
- _id: EM-Fac
- _id: RySh
doi: 10.1371/journal.pbio.3002879
ec_funded: 1
external_id:
  isi:
  - '001358568700003'
  pmid:
  - '39556620'
file:
- access_level: open_access
  checksum: 7de2dcb50deb65dde05c80082bb85a82
  content_type: application/pdf
  creator: dernst
  date_created: 2024-12-03T08:56:53Z
  date_updated: 2024-12-03T08:56:53Z
  file_id: '18608'
  file_name: 2024_PloSBio_Kim.pdf
  file_size: 3057631
  relation: main_file
  success: 1
file_date_updated: 2024-12-03T08:56:53Z
fulldoi: https://doi.org/10.1371/journal.pbio.3002879
has_accepted_license: '1'
intvolume: '        22'
isi: 1
issue: '11'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '692692'
  name: Biophysics and circuit function of a giant cortical glutamatergic synapse
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z00312
  name: Synaptic communication in neuronal microcircuits
- _id: bd88be38-d553-11ed-ba76-81d5a70a6ef5
  grant_number: P36232
  name: Mechanisms of GABA release in hippocampal circuits
- _id: b1b85715-d554-11ed-a5ad-84a07fc9f18e
  grant_number: I06166
  name: Structural & functional basis of presynaptic plasticity
- _id: 25C3DBB6-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: W01205
  name: Zellkommunikation in Gesundheit und Krankheit
- _id: 3AC91DDA-15DF-11EA-824D-93A3E7B544D1
  call_identifier: FWF
  name: FWF Open Access Fund
publication: PLoS Biology
publication_identifier:
  eissn:
  - 1545-7885
  issn:
  - 1544-9173
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
related_material:
  record:
  - id: '18296'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic
  vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 22
year: '2024'
...
---
_id: '18296'
abstract:
- lang: eng
  text: It is widely believed that information storage in neuronal circuits involves
    nanoscopic structural changes at synapses, resulting in the formation of synaptic
    engrams. However, direct evidence for this hypothesis is lacking. To test this
    conjecture, we combined chemical potentiation, functional analysis by paired pre-postsynaptic
    recordings, and structural analysis by electron microscopy (EM) and freeze-fracture
    replica labeling (FRL) at the murine hippocampal mossy fiber synapse, a key synapse
    in the trisynaptic circuit of the hippocampus. Biophysical analysis of synaptic
    transmission revealed that forskolin-induced chemical potentiation increased the
    readily releasable vesicle pool size and vesicular release probability by 146%
    and 49%, respectively. Structural analysis of mossy fiber synapses by EM and FRL
    demonstrated an increase in the number of vesicles close to the plasma membrane
    and the number of clusters of the priming protein Munc13-1, indicating an increase
    in the number of both docked and primed vesicles. Furthermore, FRL analysis revealed
    a significant reduction of the distance between Munc13-1 and CaV2.1 Ca2+ channels,
    suggesting reconfiguration of the channel-vesicle coupling nanotopography. Our
    results indicate that presynaptic plasticity is associated with structural reorganization
    of active zones. We propose that changes in potential nanoscopic organization
    at synaptic vesicle release sites may be correlates of learning and memory at
    a plastic central synapse.
article_processing_charge: No
author:
- first_name: Olena
  full_name: Kim, Olena
  id: 3F8ABDDA-F248-11E8-B48F-1D18A9856A87
  last_name: Kim
  orcid: 0000-0003-2344-1039
citation:
  ama: Kim O. Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of
    synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber
    boutons. 2024. doi:<a href="https://doi.org/10.15479/AT:ISTA:18296">10.15479/AT:ISTA:18296</a>
  apa: Kim, O. (2024). Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration
    of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber
    boutons. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:18296">https://doi.org/10.15479/AT:ISTA:18296</a>
  chicago: Kim, Olena. “Presynaptic CAMP-PKA-Mediated Potentiation Induces Reconfiguration
    of Synaptic Vesicle Pools and Channel-Vesicle Coupling at Hippocampal Mossy Fiber
    Boutons.” Institute of Science and Technology Austria, 2024. <a href="https://doi.org/10.15479/AT:ISTA:18296">https://doi.org/10.15479/AT:ISTA:18296</a>.
  ieee: O. Kim, “Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration
    of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber
    boutons.” Institute of Science and Technology Austria, 2024.
  ista: Kim O. 2024. Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration
    of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber
    boutons, Institute of Science and Technology Austria, <a href="https://doi.org/10.15479/AT:ISTA:18296">10.15479/AT:ISTA:18296</a>.
  mla: Kim, Olena. <i>Presynaptic CAMP-PKA-Mediated Potentiation Induces Reconfiguration
    of Synaptic Vesicle Pools and Channel-Vesicle Coupling at Hippocampal Mossy Fiber
    Boutons</i>. Institute of Science and Technology Austria, 2024, doi:<a href="https://doi.org/10.15479/AT:ISTA:18296">10.15479/AT:ISTA:18296</a>.
  short: O. Kim, (2024).
contributor:
- contributor_type: researcher
  first_name: Olena
  id: 3F8ABDDA-F248-11E8-B48F-1D18A9856A87
  last_name: Kim
- contributor_type: researcher
  first_name: Yuji
  id: 3337E116-F248-11E8-B48F-1D18A9856A87
  last_name: Okamoto
  orcid: 0000-0003-0408-6094
- contributor_type: researcher
  first_name: Walter
  id: 3F99E422-F248-11E8-B48F-1D18A9856A87
  last_name: Kaufmann
  orcid: 0000-0001-9735-5315
- contributor_type: researcher
  first_name: 'Nils '
  last_name: Brose
- contributor_type: researcher
  first_name: Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- contributor_type: supervisor
  first_name: Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
corr_author: '1'
date_created: 2024-10-11T10:12:17Z
date_published: 2024-10-11T00:00:00Z
date_updated: 2026-09-14T08:48:01Z
day: '11'
ddc:
- '570'
department:
- _id: PeJo
- _id: RySh
- _id: EM-Fac
doi: 10.15479/AT:ISTA:18296
ec_funded: 1
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  checksum: 0a977e7df54c418251b10dfd3f8a015c
  content_type: application/zip
  creator: okim
  date_created: 2024-10-11T10:04:19Z
  date_updated: 2024-10-11T10:04:19Z
  file_id: '18297'
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  file_size: 164382
  relation: main_file
  success: 1
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  date_created: 2024-10-11T10:04:23Z
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  file_id: '18298'
  file_name: info.txt
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file_date_updated: 2024-10-11T10:04:23Z
fulldoi: https://doi.org/10.15479/AT:ISTA:18296
has_accepted_license: '1'
keyword:
- Hippocampal mossy fiber synapses
- short-term potentiation
- long-term potentiation
- presynaptic plasticity
- electron microscopy
- freeze-fracture replica labeling
- paired recordings
- forskolin
- cyclic adenosine monophosphate (cAMP)
- protein kinase A (PKA)
- neuromodulation
- synaptic vesicle pools
- presynaptic Ca2+ channels
- Munc13
- docking
- priming
- active zone
month: '10'
oa: 1
oa_version: Submitted Version
project:
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '692692'
  name: Biophysics and circuit function of a giant cortical glutamatergic synapse
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '18603'
    relation: used_in_publication
    status: public
status: public
title: Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic
  vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: research_data
user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d
year: '2024'
...
---
OA_place: publisher
OA_type: hybrid
_id: '18492'
abstract:
- lang: eng
  text: 'Surveys in the Milky Way and Large Magellanic Cloud have revealed that the
    majority of massive stars will interact with companions during their lives. However,
    knowledge of the binary properties of massive stars at low metallicity, and therefore
    in conditions approaching those of the Early Universe, remain sparse. We present
    the Binarity at LOw Metallicity (BLOeM) campaign, an ESO large programme designed
    to obtain 25 epochs of spectroscopy for 929 massive stars in the Small Magellanic
    Cloud, allowing us to probe multiplicity in the lowest-metallicity conditions
    to date (Z = 0.2 Z⊙). BLOeM will provide (i) the binary fraction, (ii) the orbital
    configurations of systems with periods of P ≲ 3 yr, (iii) dormant black-hole binary
    candidates (OB+BH), and (iv) a legacy database of physical parameters of massive
    stars at low metallicity. Main sequence (OB-type) and evolved (OBAF-type) massive
    stars are observed with the LR02 setup of the GIRAFFE instrument of the Very Large
    Telescope (3960–4570 Å resolving power R = 6200; typical signal-to-noise ratio(S/N)
    ≈70–100). This paper utilises the first nine epochs obtained over a three-month
    time period. We describe the survey and data reduction, perform a spectral classification
    of the stacked spectra, and construct a Hertzsprung-Russell diagram of the sample
    via spectral-type and photometric calibrations. Our detailed classification reveals
    that the sample covers spectral types from O4 to F5, spanning the effective temperature
    and luminosity ranges 6.5 ≲ Teff/kK ≲ 45 and 3.7 < log L/L⊙ < 6.1 and initial
    masses of 8 ≲ Mini ≲ 80 M⊙. The sample comprises 159 O-type stars, 331 early B-type
    (B0–3) dwarfs and giants (luminosity classes V–III), 303 early B-type supergiants
    (II–I), and 136 late-type BAF supergiants. At least 82 stars are OBe stars: 20
    O-type and 62 B-type (13% and 11% of the respective samples). In addition, the
    sample includes 4 high-mass X-ray binaries, 3 stars resembling luminous blue variables,
    2 bloated stripped-star candidates, 2 candidate magnetic stars, and 74 eclipsing
    binaries.'
acknowledgement: 'The research leading to these results has received funding from
  the European Research Council (ERC) under the European Union’s Horizon 2020 research
  and innovation programme (grant agreement numbers 772225: MULTIPLES). PAC and JMB
  are supported by the Science and Technology Facilities Council research grant ST/V000853/1
  (PI. V. Dhillon). DMB gratefully acknowledges support from UK Research and Innovation
  (UKRI) in the form of a Frontier Research grant under the UK government’s ERC Horizon
  Europe funding guarantee (SYMPHONY; PI Bowman; grant number: EP/Y031059/1), and
  a Royal Society University Research Fellowship (PI Bowman; grant number: URF\R1\231631).
  ZK acknowledges support from JSPS Kakenhi Grant-in-Aid for Scientific Research (23K19071).
  IM acknowledges support from the Australian Research Council (ARC) Centre of Excellence
  for Gravitational Wave Discovery (OzGrav), through project number CE230100016. AACS,
  VR, RRL, and MBP are funded by the Deutsche Forschungsgemeinschaft (DFG, German
  Research Foundation) in the form of an Emmy Noether Research Group – Project-ID
  445674056 (SA4064/1-1, PI Sander). GGT and JJ are supported by the German Deutsche
  Forschungsgemeinschaft (DFG) under Project-ID 496854903 (SA4064/2-1, PI Sander)
  VR, GGT, and AACS further acknowledge support from the Federal Ministry of Education
  and Research (BMBF) and the Baden-Württemberg Ministry of Science as part of the
  Excellence Strategy of the German Federal and State Governments. ECS acknowledges
  financial support by the Federal Ministry for Economic Affairs and Climate Action
  (BMWK) via the German Aerospace Center (Deutsches Zentrum für Luft- und Raumfahrt,
  DLR) grant 50 OR 2306 (PI: Ramachandran/Sander). This work has received funding
  from the European Research Council (ERC) under the European Union’s Horizon 2020
  research and innovation programme (Grant agreement No. 945806) and is supported
  by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s
  Excellence Strategy EXC 2181/1-390900948 (the Heidelberg STRUCTURES Excellence Cluster).
  LMO is thankful for the funding provided by the DFG grant 443790621. This paper
  benefited from discussions at the International Space Science Institute (ISSI) in
  Bern through ISSI International Team project 512 (Multiwavelength View on Massive
  Stars in the Era of Multimessenger Astronomy). DP acknowledges financial support
  by the Deutsches Zentrum für Luft und Raumfahrt (DLR) grant FKZ 50OR2005. JIV acknowledges
  the European Research Council for support from the ERC Advanced grant ERC-2021-ADG101054731.
  JSV is supported by STFC (Science and Technology Facilities Council) funding under
  grant number ST/V000233/1. GH, SS-D, SRB and AH acknowledge support from the State
  Research Agency (AEI) of the Spanish Ministry of Science and Innovation (MICIN)
  and the European Regional Development Fund, FEDER under grants PID2021-122397NB-C21
  and CEX2019-000920-S. SRB also acknowledges financial support by NextGeneration
  EU/PRTR and MIU (UNI/551/2021) through grant Margarita Salas-ULL. DFR is thankful
  for the support of the CAPES-Br and FAPERJ/DSC-10 (SEI-260003/001630/2023). F.N.,
  and L.R.P. acknowledge support by grants PID2019-105552RB-C41 and PID2022-137779OB-C41
  funded by MCIN/AEI/10.13039/501100011033 by “ERDF A way of making Europe”. MG acknowledges
  financial support from the grants PID2021-125485NB-C22, CEX2019-000918-M funded
  by MCIN/AEI/10.13039/501100011033 (State Agency for Research of the Spanish Ministry
  of Science and Innovation) and SGR-2021-01069 (AGAUR). GM acknowledges funding support
  from the European Research Council (ERC) under the European Union’s Horizon 2020
  research and innovation programme (Grant agreement No. 772086). JMA acknowledges
  support from the Spanish Government Ministerio de Ciencia e Innovación and Agencia
  Estatal de Investigación (10.13 039/501 100 011 033) through grant PID2022-136640
  NB-C22 and from the Consejo Superior de Investigaciones Científicas (CSIC) through
  grant 2022-AEP 005. MP is supported by the BEKKER fellowship BPN/BEK/2022/1/00106
  from the Polish National Agency for Academic Exchange. KS is funded by the National
  Science Center (NCN), Poland, under grant number OPUS 2021/41/B/ST9/00757. JM acknowledges
  support from a Royal Society-Science Foundation Ireland University Research Fellowship.
  SJ acknowledges support from the FWO PhD fellowship under project 11E1721N. FB acknowledges
  the support of the European Research Council (ERC) Horizon Europe under grant agreement
  number 101044048.'
article_number: A289
article_processing_charge: Yes (in subscription journal)
article_type: original
arxiv: 1
author:
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- first_name: P. A.
  full_name: Crowther, P. A.
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- first_name: D. J.
  full_name: Lennon, D. J.
  last_name: Lennon
- first_name: M.
  full_name: Abdul-Masih, M.
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- first_name: L. A.
  full_name: Almeida, L. A.
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- first_name: F.
  full_name: Backs, F.
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  full_name: Berlanas, S. R.
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  full_name: Bernini-Peron, M.
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- first_name: J. M.
  full_name: Bestenlehner, J. M.
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- first_name: D. M.
  full_name: Bowman, D. M.
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- first_name: V. A.
  full_name: Bronner, V. A.
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  id: d0648d0c-0f64-11ee-a2e0-dd0faa2e4f7d
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  orcid: 0000-0002-6960-6911
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citation:
  ama: 'Shenar T, Bodensteiner J, Sana H, et al. Binarity at LOw Metallicity (BLOeM):
    A spectroscopic VLT monitoring survey of massive stars in the SMC. <i>Astronomy
    &#38; Astrophysics</i>. 2024;690. doi:<a href="https://doi.org/10.1051/0004-6361/202451586">10.1051/0004-6361/202451586</a>'
  apa: 'Shenar, T., Bodensteiner, J., Sana, H., Crowther, P. A., Lennon, D. J., Abdul-Masih,
    M., … Willcox, R. (2024). Binarity at LOw Metallicity (BLOeM): A spectroscopic
    VLT monitoring survey of massive stars in the SMC. <i>Astronomy &#38; Astrophysics</i>.
    EDP Sciences. <a href="https://doi.org/10.1051/0004-6361/202451586">https://doi.org/10.1051/0004-6361/202451586</a>'
  chicago: 'Shenar, T., J. Bodensteiner, H. Sana, P. A. Crowther, D. J. Lennon, M.
    Abdul-Masih, L. A. Almeida, et al. “Binarity at LOw Metallicity (BLOeM): A Spectroscopic
    VLT Monitoring Survey of Massive Stars in the SMC.” <i>Astronomy &#38; Astrophysics</i>.
    EDP Sciences, 2024. <a href="https://doi.org/10.1051/0004-6361/202451586">https://doi.org/10.1051/0004-6361/202451586</a>.'
  ieee: 'T. Shenar <i>et al.</i>, “Binarity at LOw Metallicity (BLOeM): A spectroscopic
    VLT monitoring survey of massive stars in the SMC,” <i>Astronomy &#38; Astrophysics</i>,
    vol. 690. EDP Sciences, 2024.'
  ista: 'Shenar T, Bodensteiner J, Sana H, Crowther PA, Lennon DJ, Abdul-Masih M,
    Almeida LA, Backs F, Berlanas SR, Bernini-Peron M, Bestenlehner JM, Bowman DM,
    Bronner VA, Britavskiy N, De Koter A, De Mink SE, Deshmukh K, Evans CJ, Fabry
    M, Gieles M, Gilkis A, González-Torà G, Gräfener G, Götberg YLL, Hawcroft C, Hénault-Brunet
    V, Herrero A, Holgado G, Janssens S, Johnston C, Josiek J, Justham S, Kalari VM,
    Katabi ZZ, Keszthelyi Z, Klencki J, Kubát J, Kubátová B, Langer N, Lefever RR,
    Ludwig B, Mackey J, Mahy L, Maíz Apellániz J, Mandel I, Maravelias G, Marchant
    P, Menon A, Najarro F, Oskinova LM, O’Grady AJG, Ovadia R, Patrick LR, Pauli D,
    Pawlak M, Ramachandran V, Renzo M, Rocha DF, Sander AAC, Sayada T, Schneider FRN,
    Schootemeijer A, Schösser EC, Schürmann C, Sen K, Shahaf S, Simón-Díaz S, Stoop
    M, Toonen S, Tramper F, Van Loon JT, Valli R, Van Son LAC, Vigna-Gómez A, Villaseñor
    JI, Vink JS, Wang C, Willcox R. 2024. Binarity at LOw Metallicity (BLOeM): A spectroscopic
    VLT monitoring survey of massive stars in the SMC. Astronomy &#38; Astrophysics.
    690, A289.'
  mla: 'Shenar, T., et al. “Binarity at LOw Metallicity (BLOeM): A Spectroscopic VLT
    Monitoring Survey of Massive Stars in the SMC.” <i>Astronomy &#38; Astrophysics</i>,
    vol. 690, A289, EDP Sciences, 2024, doi:<a href="https://doi.org/10.1051/0004-6361/202451586">10.1051/0004-6361/202451586</a>.'
  short: T. Shenar, J. Bodensteiner, H. Sana, P.A. Crowther, D.J. Lennon, M. Abdul-Masih,
    L.A. Almeida, F. Backs, S.R. Berlanas, M. Bernini-Peron, J.M. Bestenlehner, D.M.
    Bowman, V.A. Bronner, N. Britavskiy, A. De Koter, S.E. De Mink, K. Deshmukh, C.J.
    Evans, M. Fabry, M. Gieles, A. Gilkis, G. González-Torà, G. Gräfener, Y.L.L. Götberg,
    C. Hawcroft, V. Hénault-Brunet, A. Herrero, G. Holgado, S. Janssens, C. Johnston,
    J. Josiek, S. Justham, V.M. Kalari, Z.Z. Katabi, Z. Keszthelyi, J. Klencki, J.
    Kubát, B. Kubátová, N. Langer, R.R. Lefever, B. Ludwig, J. Mackey, L. Mahy, J.
    Maíz Apellániz, I. Mandel, G. Maravelias, P. Marchant, A. Menon, F. Najarro, L.M.
    Oskinova, A.J.G. O’Grady, R. Ovadia, L.R. Patrick, D. Pauli, M. Pawlak, V. Ramachandran,
    M. Renzo, D.F. Rocha, A.A.C. Sander, T. Sayada, F.R.N. Schneider, A. Schootemeijer,
    E.C. Schösser, C. Schürmann, K. Sen, S. Shahaf, S. Simón-Díaz, M. Stoop, S. Toonen,
    F. Tramper, J.T. Van Loon, R. Valli, L.A.C. Van Son, A. Vigna-Gómez, J.I. Villaseñor,
    J.S. Vink, C. Wang, R. Willcox, Astronomy &#38; Astrophysics 690 (2024).
das_tickbox: '1'
date_created: 2024-11-03T23:01:44Z
date_published: 2024-10-01T00:00:00Z
date_updated: 2026-09-16T10:50:17Z
day: '01'
ddc:
- '520'
department:
- _id: YlGo
doi: 10.1051/0004-6361/202451586
external_id:
  arxiv:
  - '2407.14593'
  isi:
  - '001336770600014'
file:
- access_level: open_access
  checksum: b378b36726591f3479a927d924ab8e77
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  creator: dernst
  date_created: 2024-11-04T09:52:26Z
  date_updated: 2024-11-04T09:52:26Z
  file_id: '18500'
  file_name: 2024_AstronomyAstrophysics_Shenar.pdf
  file_size: 4267349
  relation: main_file
  success: 1
file_date_updated: 2024-11-04T09:52:26Z
fulldoi: https://doi.org/10.1051/0004-6361/202451586
has_accepted_license: '1'
intvolume: '       690'
isi: 1
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
publication: Astronomy & Astrophysics
publication_identifier:
  eissn:
  - 1432-0746
  issn:
  - 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: 'Binarity at LOw Metallicity (BLOeM): A spectroscopic VLT monitoring survey
  of massive stars in the SMC'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 690
year: '2024'
...
---
APC_amount: 2933,65 EUR
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '14980'
abstract:
- lang: eng
  text: Precision sensing and manipulation of milligram-scale mechanical oscillators
    has attracted growing interest in the fields of table-top explorations of gravity
    and tests of quantum mechanics at macroscopic scales. Torsional oscillators present
    an opportunity in this regard due to their remarked isolation from environmental
    noise. For torsional motion, an effective employment of optical cavities to enhance
    optomechanical interactions—as already established for linear oscillators—so far
    faced certain challenges. Here, we propose a concept for sensing and manipulating
    torsional motion, where exclusively the torsional rotations of a pendulum are
    mapped onto the path length of a single two-mirror optical cavity. The concept
    inherently alleviates many limitations of previous approaches. A proof-of-principle
    experiment is conducted with a rigidly controlled pendulum to explore the sensing
    aspects of the concept and to identify practical limitations in a potential state-of-the
    art setup. Based on this study, we anticipate development of precision torque
    sensors utilizing torsional pendulums that can support sensitivities below 10−19Nm/√Hz,
    while the motion of the pendulums are dominated by quantum radiation pressure
    noise at sub-microwatts of incoming laser power. These developments will provide
    horizons for experiments at the interface of quantum mechanics and gravity.
acknowledgement: "We thank Pere Rosselló for his contributions to the initial modeling
  of the presented sensing technique. This work was supported by Institute of Science
  and Technology Austria, and\r\nthe European Research Council under Grant No. 101087907
  (ERC CoG QuHAMP)."
article_number: '013141'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Sofya
  full_name: Agafonova, Sofya
  id: 09501ff6-dca7-11ea-a8ae-b3e0b9166e80
  last_name: Agafonova
  orcid: 0000-0003-0582-2946
- first_name: Umang
  full_name: Mishra, Umang
  id: 4328fa4c-f128-11eb-9611-c107b0fe4d51
  last_name: Mishra
- first_name: Fritz R
  full_name: Diorico, Fritz R
  id: 2E054C4C-F248-11E8-B48F-1D18A9856A87
  last_name: Diorico
  orcid: 0000-0002-4947-8924
- first_name: Onur
  full_name: Hosten, Onur
  id: 4C02D85E-F248-11E8-B48F-1D18A9856A87
  last_name: Hosten
  orcid: 0000-0002-2031-204X
citation:
  ama: Agafonova S, Mishra U, Diorico FR, Hosten O. Zigzag optical cavity for sensing
    and controlling torsional motion. <i>Physical Review Research</i>. 2024;6(1).
    doi:<a href="https://doi.org/10.1103/physrevresearch.6.013141">10.1103/physrevresearch.6.013141</a>
  apa: Agafonova, S., Mishra, U., Diorico, F. R., &#38; Hosten, O. (2024). Zigzag
    optical cavity for sensing and controlling torsional motion. <i>Physical Review
    Research</i>. American Physical Society. <a href="https://doi.org/10.1103/physrevresearch.6.013141">https://doi.org/10.1103/physrevresearch.6.013141</a>
  chicago: Agafonova, Sofia, Umang Mishra, Fritz R Diorico, and Onur Hosten. “Zigzag
    Optical Cavity for Sensing and Controlling Torsional Motion.” <i>Physical Review
    Research</i>. American Physical Society, 2024. <a href="https://doi.org/10.1103/physrevresearch.6.013141">https://doi.org/10.1103/physrevresearch.6.013141</a>.
  ieee: S. Agafonova, U. Mishra, F. R. Diorico, and O. Hosten, “Zigzag optical cavity
    for sensing and controlling torsional motion,” <i>Physical Review Research</i>,
    vol. 6, no. 1. American Physical Society, 2024.
  ista: Agafonova S, Mishra U, Diorico FR, Hosten O. 2024. Zigzag optical cavity for
    sensing and controlling torsional motion. Physical Review Research. 6(1), 013141.
  mla: Agafonova, Sofia, et al. “Zigzag Optical Cavity for Sensing and Controlling
    Torsional Motion.” <i>Physical Review Research</i>, vol. 6, no. 1, 013141, American
    Physical Society, 2024, doi:<a href="https://doi.org/10.1103/physrevresearch.6.013141">10.1103/physrevresearch.6.013141</a>.
  short: S. Agafonova, U. Mishra, F.R. Diorico, O. Hosten, Physical Review Research
    6 (2024).
corr_author: '1'
das_tickbox: '0'
date_created: 2024-02-12T11:42:18Z
date_published: 2024-02-05T00:00:00Z
date_updated: 2026-09-17T09:13:08Z
day: '05'
ddc:
- '530'
department:
- _id: OnHo
doi: 10.1103/physrevresearch.6.013141
external_id:
  arxiv:
  - '2306.12804'
file:
- access_level: open_access
  checksum: 3a39ebffb24c1cc1dd0b547a726dc52d
  content_type: application/pdf
  creator: dernst
  date_created: 2024-02-12T11:46:50Z
  date_updated: 2024-02-12T11:46:50Z
  file_id: '14981'
  file_name: 2024_PhysicalRevResearch_Agafonova.pdf
  file_size: 1437167
  relation: main_file
  success: 1
file_date_updated: 2024-02-12T11:46:50Z
fulldoi: https://doi.org/10.1103/physrevresearch.6.013141
has_accepted_license: '1'
intvolume: '         6'
issue: '1'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: bdb2a702-d553-11ed-ba76-f12e3e5a3bc6
  grant_number: '101087907'
  name: 'A quantum hybrid of atoms and milligram-scale pendulums: towards gravitational
    quantum mechanics'
publication: Physical Review Research
publication_identifier:
  eissn:
  - 2643-1564
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Zigzag optical cavity for sensing and controlling torsional motion
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 6
year: '2024'
...
---
OA_place: publisher
OA_type: hybrid
_id: '18910'
abstract:
- lang: eng
  text: Proteins often undergo large-scale conformational transitions, in which secondary
    and tertiary structure elements (loops, helices, and domains) change their structures
    or their positions with respect to each other. Simple considerations suggest that
    such dynamics should be relatively fast, but the functional cycles of many proteins
    are often relatively slow. Sophisticated experimental methods are starting to
    tackle this dichotomy and shed light on the contribution of large-scale conformational
    dynamics to protein function. In this review, we focus on the contribution of
    single-molecule Förster resonance energy transfer and nuclear magnetic resonance
    (NMR) spectroscopies to the study of conformational dynamics. We briefly describe
    the state of the art in each of these techniques and then point out their similarities
    and differences, as well as the relative strengths and weaknesses of each. Several
    case studies, in which the connection between fast conformational dynamics and
    slower function has been demonstrated, are then introduced and discussed. These
    examples include both enzymes and large protein machines, some of which have been
    studied by both NMR and fluorescence spectroscopies.
acknowledgement: G.H. is the incumbent of the Hilda Pomeraniec Memorial Professorial
  Chair. He has been partially funded by the European Research Council under the European
  Union's Horizon 2020 research and innovation program (grant 742637, SMALLOSTERY),
  by National Science Foundation–US-Israel Binational Science Foundation grant 2021700,
  and by an Israel Science Foundation Breakthrough grant (1924/22). P.S. acknowledges
  funding from the Austrian Science Fund (project “AlloSpace,” I05812) and intramural
  funding from the Institute of Science and Technology Austria.
article_processing_charge: No
article_type: original
author:
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
- first_name: Gilad
  full_name: Haran, Gilad
  last_name: Haran
citation:
  ama: Schanda P, Haran G. NMR and single-molecule FRET insights into fast protein
    motions and their relation to function. <i>Annual Review of Biophysics</i>. 2024;53:247-273.
    doi:<a href="https://doi.org/10.1146/annurev-biophys-070323-022428">10.1146/annurev-biophys-070323-022428</a>
  apa: Schanda, P., &#38; Haran, G. (2024). NMR and single-molecule FRET insights
    into fast protein motions and their relation to function. <i>Annual Review of
    Biophysics</i>. Annual Reviews. <a href="https://doi.org/10.1146/annurev-biophys-070323-022428">https://doi.org/10.1146/annurev-biophys-070323-022428</a>
  chicago: Schanda, Paul, and Gilad Haran. “NMR and Single-Molecule FRET Insights
    into Fast Protein Motions and Their Relation to Function.” <i>Annual Review of
    Biophysics</i>. Annual Reviews, 2024. <a href="https://doi.org/10.1146/annurev-biophys-070323-022428">https://doi.org/10.1146/annurev-biophys-070323-022428</a>.
  ieee: P. Schanda and G. Haran, “NMR and single-molecule FRET insights into fast
    protein motions and their relation to function,” <i>Annual Review of Biophysics</i>,
    vol. 53. Annual Reviews, pp. 247–273, 2024.
  ista: Schanda P, Haran G. 2024. NMR and single-molecule FRET insights into fast
    protein motions and their relation to function. Annual Review of Biophysics. 53,
    247–273.
  mla: Schanda, Paul, and Gilad Haran. “NMR and Single-Molecule FRET Insights into
    Fast Protein Motions and Their Relation to Function.” <i>Annual Review of Biophysics</i>,
    vol. 53, Annual Reviews, 2024, pp. 247–73, doi:<a href="https://doi.org/10.1146/annurev-biophys-070323-022428">10.1146/annurev-biophys-070323-022428</a>.
  short: P. Schanda, G. Haran, Annual Review of Biophysics 53 (2024) 247–273.
corr_author: '1'
das_tickbox: '0'
date_created: 2025-01-27T13:40:34Z
date_published: 2024-07-01T00:00:00Z
date_updated: 2026-09-17T09:44:33Z
day: '01'
ddc:
- '570'
department:
- _id: PaSc
doi: 10.1146/annurev-biophys-070323-022428
external_id:
  isi:
  - '001278237500012'
  pmid:
  - '38346243'
file:
- access_level: open_access
  checksum: c90861542ae3f9147939030d5bafed3c
  content_type: application/pdf
  creator: dernst
  date_created: 2025-01-27T13:44:59Z
  date_updated: 2025-01-27T13:44:59Z
  file_id: '18911'
  file_name: 2024_AnnualReviews_Schanda.pdf
  file_size: 3025589
  relation: main_file
  success: 1
file_date_updated: 2025-01-27T13:44:59Z
fulldoi: https://doi.org/10.1146/annurev-biophys-070323-022428
has_accepted_license: '1'
intvolume: '        53'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 247-273
pmid: 1
project:
- _id: eb9c82eb-77a9-11ec-83b8-aadd536561cf
  grant_number: I05812
  name: AlloSpace. The emergence and mechanisms of allostery
publication: Annual Review of Biophysics
publication_identifier:
  eissn:
  - 1936-1238
  issn:
  - 1936-122X
publication_status: published
publisher: Annual Reviews
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: NMR and single-molecule FRET insights into fast protein motions and their relation
  to function
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 53
year: '2024'
...
---
_id: '15117'
abstract:
- lang: eng
  text: 'The hippocampal mossy fiber synapse, formed between axons of dentate gyrus
    granule cells and dendrites of CA3 pyramidal neurons, is a key synapse in the
    trisynaptic circuitry of the hippocampus. Because of its comparatively large size,
    this synapse is accessible to direct presynaptic recording, allowing a rigorous
    investigation of the biophysical mechanisms of synaptic transmission and plasticity.
    Furthermore, because of its placement in the very center of the hippocampal memory
    circuit, this synapse seems to be critically involved in several higher network
    functions, such as learning, memory, pattern separation, and pattern completion.
    Recent work based on new technologies in both nanoanatomy and nanophysiology,
    including presynaptic patch-clamp recording, paired recording, super-resolution
    light microscopy, and freeze-fracture and “flash-and-freeze” electron microscopy,
    has provided new insights into the structure, biophysics, and network function
    of this intriguing synapse. This brings us one step closer to answering a fundamental
    question in neuroscience: how basic synaptic properties shape higher network computations.'
acknowledgement: "We thank previous students, postdocs, and collaborators, particularly
  J. Geiger, and (in alphabetical order) H. Alle, J. Bischofberger, C. Borges-Merjane,
  D. Engel, M. Frotscher, S. Hallermann, M. Heckmann, S. Jamrichova, O. Kim, L. Li,
  K. Lichter, P. Lin, J. Lübke, Y. Okamoto, C. Pawlu, C. Schmidt-Hieber, N. Spruston,
  and N. Vyleta for their outstanding experimental contributions. We also thank P.
  Castillo, J. Geiger, T. Sakaba, S. Siegert, T. Vogels, and J. Watson for critically
  reading the manuscript, E. Kralli-Beller for text editing, and J. Malikovic and
  L. Slomianka for useful discussions. We apologize that, due to space constraints,
  not all relevant papers could be cited.\r\nThis project was supported by the European
  Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
  program (grant agreement 692692, AdG “GIANTSYN”) and the Fonds zur Förderung der
  Wissenschaftlichen Forschung (Z 312-B27, Wittgenstein Award; P 36232-B, stand-alone
  grant), both to P.J."
article_processing_charge: No
article_type: review
author:
- first_name: David H
  full_name: Vandael, David H
  id: 3AE48E0A-F248-11E8-B48F-1D18A9856A87
  last_name: Vandael
  orcid: 0000-0001-7577-1676
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Vandael DH, Jonas PM. Structure, biophysics, and circuit function of a “giant”
    cortical presynaptic terminal. <i>Science</i>. 2024;383(6687):eadg6757. doi:<a
    href="https://doi.org/10.1126/science.adg6757">10.1126/science.adg6757</a>
  apa: Vandael, D. H., &#38; Jonas, P. M. (2024). Structure, biophysics, and circuit
    function of a “giant” cortical presynaptic terminal. <i>Science</i>. AAAS. <a
    href="https://doi.org/10.1126/science.adg6757">https://doi.org/10.1126/science.adg6757</a>
  chicago: Vandael, David H, and Peter M Jonas. “Structure, Biophysics, and Circuit
    Function of a ‘Giant’ Cortical Presynaptic Terminal.” <i>Science</i>. AAAS, 2024.
    <a href="https://doi.org/10.1126/science.adg6757">https://doi.org/10.1126/science.adg6757</a>.
  ieee: D. H. Vandael and P. M. Jonas, “Structure, biophysics, and circuit function
    of a ‘giant’ cortical presynaptic terminal,” <i>Science</i>, vol. 383, no. 6687.
    AAAS, p. eadg6757, 2024.
  ista: Vandael DH, Jonas PM. 2024. Structure, biophysics, and circuit function of
    a ‘giant’ cortical presynaptic terminal. Science. 383(6687), eadg6757.
  mla: Vandael, David H., and Peter M. Jonas. “Structure, Biophysics, and Circuit
    Function of a ‘Giant’ Cortical Presynaptic Terminal.” <i>Science</i>, vol. 383,
    no. 6687, AAAS, 2024, p. eadg6757, doi:<a href="https://doi.org/10.1126/science.adg6757">10.1126/science.adg6757</a>.
  short: D.H. Vandael, P.M. Jonas, Science 383 (2024) eadg6757.
corr_author: '1'
das_tickbox: '0'
date_created: 2024-03-17T23:00:57Z
date_published: 2024-03-08T00:00:00Z
date_updated: 2026-09-17T09:49:03Z
day: '08'
department:
- _id: PeJo
doi: 10.1126/science.adg6757
ec_funded: 1
external_id:
  isi:
  - '001216996700015'
  pmid:
  - '38452088'
fulldoi: https://doi.org/10.1126/science.adg6757
intvolume: '       383'
isi: 1
issue: '6687'
language:
- iso: eng
month: '03'
oa_version: None
page: eadg6757
pmid: 1
project:
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '692692'
  name: Biophysics and circuit function of a giant cortical glutamatergic synapse
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z00312
  name: Synaptic communication in neuronal microcircuits
- _id: bd88be38-d553-11ed-ba76-81d5a70a6ef5
  grant_number: P36232
  name: Mechanisms of GABA release in hippocampal circuits
publication: Science
publication_identifier:
  eissn:
  - 1095-9203
publication_status: published
publisher: AAAS
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Structure, biophysics, and circuit function of a "giant" cortical presynaptic
  terminal
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 383
year: '2024'
...
---
_id: '18058'
abstract:
- lang: eng
  text: DNA cloning is a core technique in biomedical and biotechnological research
    and is used to assemble and modify DNA fragments at will. While DNA cloning has
    traditionally relied on restriction enzymes, recent homology-based methods offer
    improved protocols together with seamless and directional assembly of desired
    products, overcoming the main disadvantages of restriction enzyme DNA cloning.
    This chapter provides a historical perspective on DNA cloning, presents a detailed
    discussion on state-of-the-art in vitro and in vivo homology-based methodologies,
    covering the basics of how to perform all major plasmid modifications (sub-cloning,
    site-directed mutagenesis, insertions, and deletions), and gives examples of how
    to apply these techniques for complex DNA cloning projects.
article_processing_charge: No
author:
- first_name: Jake
  full_name: Watson, Jake
  id: 63836096-4690-11EA-BD4E-32803DDC885E
  last_name: Watson
  orcid: 0000-0002-8698-3823
- first_name: Sandra
  full_name: Arroyo-Urea, Sandra
  last_name: Arroyo-Urea
- first_name: Javier
  full_name: García-Nafría, Javier
  last_name: García-Nafría
citation:
  ama: 'Watson J, Arroyo-Urea S, García-Nafría J. DNA Cloning. In: Liu D, ed. <i>Handbook
    of Molecular Biotechnology</i>. 1st ed. Boca Raton: CRC Press; 2024:66-72. doi:<a
    href="https://doi.org/10.1201/9781003055211-8">10.1201/9781003055211-8</a>'
  apa: 'Watson, J., Arroyo-Urea, S., &#38; García-Nafría, J. (2024). DNA Cloning.
    In D. Liu (Ed.), <i>Handbook of Molecular Biotechnology</i> (1st ed., pp. 66–72).
    Boca Raton: CRC Press. <a href="https://doi.org/10.1201/9781003055211-8">https://doi.org/10.1201/9781003055211-8</a>'
  chicago: 'Watson, Jake, Sandra Arroyo-Urea, and Javier García-Nafría. “DNA Cloning.”
    In <i>Handbook of Molecular Biotechnology</i>, edited by Dongyou Liu, 1st ed.,
    66–72. Boca Raton: CRC Press, 2024. <a href="https://doi.org/10.1201/9781003055211-8">https://doi.org/10.1201/9781003055211-8</a>.'
  ieee: 'J. Watson, S. Arroyo-Urea, and J. García-Nafría, “DNA Cloning,” in <i>Handbook
    of Molecular Biotechnology</i>, 1st ed., D. Liu, Ed. Boca Raton: CRC Press, 2024,
    pp. 66–72.'
  ista: 'Watson J, Arroyo-Urea S, García-Nafría J. 2024.DNA Cloning. In: Handbook
    of Molecular Biotechnology. , 66–72.'
  mla: Watson, Jake, et al. “DNA Cloning.” <i>Handbook of Molecular Biotechnology</i>,
    edited by Dongyou Liu, 1st ed., CRC Press, 2024, pp. 66–72, doi:<a href="https://doi.org/10.1201/9781003055211-8">10.1201/9781003055211-8</a>.
  short: J. Watson, S. Arroyo-Urea, J. García-Nafría, in:, D. Liu (Ed.), Handbook
    of Molecular Biotechnology, 1st ed., CRC Press, Boca Raton, 2024, pp. 66–72.
das_tickbox: '0'
date_created: 2024-09-11T10:40:36Z
date_published: 2024-09-05T00:00:00Z
date_updated: 2026-09-17T09:58:21Z
day: '05'
department:
- _id: PeJo
doi: 10.1201/9781003055211-8
edition: '1'
editor:
- first_name: Dongyou
  full_name: Liu, Dongyou
  last_name: Liu
fulldoi: https://doi.org/10.1201/9781003055211-8
language:
- iso: eng
month: '09'
oa_version: None
page: 66-72
place: Boca Raton
publication: Handbook of Molecular Biotechnology
publication_identifier:
  eisbn:
  - '9781003055211'
publication_status: published
publisher: CRC Press
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: DNA Cloning
type: book_chapter
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
year: '2024'
...
---
OA_place: publisher
OA_type: hybrid
_id: '18587'
abstract:
- lang: eng
  text: Many scientific breakthroughs have depended on animal research, yet the ethical
    concerns surrounding the use of animals in experimentation have long prompted
    discussions about humane treatment and responsible scientific practice. First
    articulated by Russell and Burch, the 3Rs Principles of Replacement, Reduction,
    and Refinement have gained widespread recognition as basic guidelines for animal
    research. Over time, the 3Rs have transcended the research community, influencing
    policy decisions, animal welfare advocacy and public perception of animal experimentation.
    Despite their broad acceptance, interpretations of the 3Rs vary substantially,
    shaping statutory frameworks at various levels, with both technical and practical
    impacts.
acknowledgement: This publication is based upon work from the Ethics Crossover Group
  within the COST Action IMPROVE (“3Rs concepts to improve the quality of biomedical
  science”), CA21139, supported by COST (European Cooperation in Science and Technology).
  We acknowledge the input and advice from Dr. Susanna Louhimies.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Jan
  full_name: Lauwereyns, Jan
  last_name: Lauwereyns
- first_name: Jeffrey
  full_name: Bajramovic, Jeffrey
  last_name: Bajramovic
- first_name: Bettina
  full_name: Bert, Bettina
  last_name: Bert
- first_name: Samuel
  full_name: Camenzind, Samuel
  last_name: Camenzind
- first_name: Joery
  full_name: De Kock, Joery
  last_name: De Kock
- first_name: Alisa
  full_name: Elezović, Alisa
  last_name: Elezović
- first_name: Sevilay
  full_name: Erden, Sevilay
  last_name: Erden
- first_name: Fernando
  full_name: Gonzalez-Uarquin, Fernando
  last_name: Gonzalez-Uarquin
- first_name: Yesim Isil
  full_name: Ulman, Yesim Isil
  last_name: Ulman
- first_name: Orsolya Ivett
  full_name: Hoffmann, Orsolya Ivett
  last_name: Hoffmann
- first_name: Maria
  full_name: Kitsara, Maria
  last_name: Kitsara
- first_name: Nikolaos
  full_name: Kostomitsopoulos, Nikolaos
  last_name: Kostomitsopoulos
- first_name: Winfried
  full_name: Neuhaus, Winfried
  last_name: Neuhaus
- first_name: Benoit
  full_name: Petit-Demouliere, Benoit
  last_name: Petit-Demouliere
- first_name: Simone
  full_name: Pollo, Simone
  last_name: Pollo
- first_name: Brígida
  full_name: Riso, Brígida
  last_name: Riso
- first_name: Sophie
  full_name: Schober, Sophie
  id: 80b0a0ef-4b9f-11ec-b119-8d9d94c4a1d8
  last_name: Schober
- first_name: Athanassia
  full_name: Sotiropoulos, Athanassia
  last_name: Sotiropoulos
- first_name: Aurélie
  full_name: Thomas, Aurélie
  last_name: Thomas
- first_name: Augusto
  full_name: Vitale, Augusto
  last_name: Vitale
- first_name: Doris
  full_name: Wilflingseder, Doris
  last_name: Wilflingseder
- first_name: Arti
  full_name: Ahluwalia, Arti
  last_name: Ahluwalia
citation:
  ama: Lauwereyns J, Bajramovic J, Bert B, et al. Toward a common interpretation of
    the 3Rs principles in animal research. <i>Lab Animal</i>. 2024;53:347-350. doi:<a
    href="https://doi.org/10.1038/s41684-024-01476-2">10.1038/s41684-024-01476-2</a>
  apa: Lauwereyns, J., Bajramovic, J., Bert, B., Camenzind, S., De Kock, J., Elezović,
    A., … Ahluwalia, A. (2024). Toward a common interpretation of the 3Rs principles
    in animal research. <i>Lab Animal</i>. Springer Nature. <a href="https://doi.org/10.1038/s41684-024-01476-2">https://doi.org/10.1038/s41684-024-01476-2</a>
  chicago: Lauwereyns, Jan, Jeffrey Bajramovic, Bettina Bert, Samuel Camenzind, Joery
    De Kock, Alisa Elezović, Sevilay Erden, et al. “Toward a Common Interpretation
    of the 3Rs Principles in Animal Research.” <i>Lab Animal</i>. Springer Nature,
    2024. <a href="https://doi.org/10.1038/s41684-024-01476-2">https://doi.org/10.1038/s41684-024-01476-2</a>.
  ieee: J. Lauwereyns <i>et al.</i>, “Toward a common interpretation of the 3Rs principles
    in animal research,” <i>Lab Animal</i>, vol. 53. Springer Nature, pp. 347–350,
    2024.
  ista: Lauwereyns J, Bajramovic J, Bert B, Camenzind S, De Kock J, Elezović A, Erden
    S, Gonzalez-Uarquin F, Ulman YI, Hoffmann OI, Kitsara M, Kostomitsopoulos N, Neuhaus
    W, Petit-Demouliere B, Pollo S, Riso B, Schober S, Sotiropoulos A, Thomas A, Vitale
    A, Wilflingseder D, Ahluwalia A. 2024. Toward a common interpretation of the 3Rs
    principles in animal research. Lab Animal. 53, 347–350.
  mla: Lauwereyns, Jan, et al. “Toward a Common Interpretation of the 3Rs Principles
    in Animal Research.” <i>Lab Animal</i>, vol. 53, Springer Nature, 2024, pp. 347–50,
    doi:<a href="https://doi.org/10.1038/s41684-024-01476-2">10.1038/s41684-024-01476-2</a>.
  short: J. Lauwereyns, J. Bajramovic, B. Bert, S. Camenzind, J. De Kock, A. Elezović,
    S. Erden, F. Gonzalez-Uarquin, Y.I. Ulman, O.I. Hoffmann, M. Kitsara, N. Kostomitsopoulos,
    W. Neuhaus, B. Petit-Demouliere, S. Pollo, B. Riso, S. Schober, A. Sotiropoulos,
    A. Thomas, A. Vitale, D. Wilflingseder, A. Ahluwalia, Lab Animal 53 (2024) 347–350.
das_tickbox: '0'
date_created: 2024-11-24T23:01:49Z
date_published: 2024-12-01T00:00:00Z
date_updated: 2026-09-17T10:29:32Z
day: '01'
ddc:
- '570'
department:
- _id: PreCl
doi: 10.1038/s41684-024-01476-2
external_id:
  isi:
  - '001355264100001'
  pmid:
  - '39548348'
file:
- access_level: open_access
  checksum: 67fc140f761581a291591f075e49b88d
  content_type: application/pdf
  creator: dernst
  date_created: 2024-12-03T14:07:04Z
  date_updated: 2024-12-03T14:07:04Z
  file_id: '18614'
  file_name: 2024_LabAnimal_Lauwereyns.pdf
  file_size: 967252
  relation: main_file
  success: 1
file_date_updated: 2024-12-03T14:07:04Z
fulldoi: https://doi.org/10.1038/s41684-024-01476-2
has_accepted_license: '1'
intvolume: '        53'
isi: 1
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 347-350
pmid: 1
publication: Lab Animal
publication_identifier:
  eissn:
  - 1548-4475
  issn:
  - 0093-7355
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Toward a common interpretation of the 3Rs principles in animal research
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 53
year: '2024'
...
---
DOAJ_listed: '1'
_id: '17409'
abstract:
- lang: eng
  text: Light-driven rotary molecular motors are among the most promising classes
    of responsive molecular machines and take advantage of their intrinsic chirality
    which governs unidirectional rotation. As a consequence of their dynamic function,
    they receive considerable interest in the areas of supramolecular chemistry, asymmetric
    catalysis and responsive materials. Among the emerging classes of responsive photochromic
    molecules, multistate first-generation molecular motors driven by benign visible
    light remain unexplored, which limits the exploitation of the full potential of
    these mechanical light-powered systems. Herein, we describe a series of all-visible-light-driven
    first-generation molecular motors based on the salicylidene Schiff base functionality.
    Remarkable redshifts up to 100 nm in absorption are achieved compared to conventional
    first-generation motor structures. Taking advantage of all-visible-light-driven
    multistate motor scaffolds, adaptive behaviour is found as well, and potential
    application in multistate photoluminescence is demonstrated. These functional
    visible-light-responsive motors will likely stimulate the design and synthesis
    of more sophisticated nanomachinery with a myriad of future applications in powering
    dynamic systems.
acknowledgement: Financial support from the Netherlands Organization for Scientific
  Research (NWO-CW), the Dutch Ministry of Education, Culture and Science (Gravitation
  program No.024.001.035), the China Scholarship Council (CSC PhD Fellowship No.201808330459
  to J. S.). We thank Dr. Youxin Fu, Dr. Alexander Ryabchun, Dr. Wojciech Danowski,
  Dr. Jianyu Zhang and Yahan Shan from University of Groningen for their help to this
  project and fruitful discussions.
article_number: '6461'
article_processing_charge: Yes
article_type: original
author:
- first_name: Sven
  full_name: Van Vliet, Sven
  last_name: Van Vliet
- first_name: Jinyu
  full_name: Sheng, Jinyu
  id: 639f0526-27c9-11ee-95a6-966cd7f102d8
  last_name: Sheng
- first_name: Charlotte N.
  full_name: Stindt, Charlotte N.
  last_name: Stindt
- first_name: Ben L.
  full_name: Feringa, Ben L.
  last_name: Feringa
citation:
  ama: Van Vliet S, Sheng J, Stindt CN, Feringa BL. All-visible-light-driven salicylidene
    schiff-base-functionalized artificial molecular motors. <i>Nature Communications</i>.
    2024;15. doi:<a href="https://doi.org/10.1038/s41467-024-50587-4">10.1038/s41467-024-50587-4</a>
  apa: Van Vliet, S., Sheng, J., Stindt, C. N., &#38; Feringa, B. L. (2024). All-visible-light-driven
    salicylidene schiff-base-functionalized artificial molecular motors. <i>Nature
    Communications</i>. Springer Nature. <a href="https://doi.org/10.1038/s41467-024-50587-4">https://doi.org/10.1038/s41467-024-50587-4</a>
  chicago: Van Vliet, Sven, Jinyu Sheng, Charlotte N. Stindt, and Ben L. Feringa.
    “All-Visible-Light-Driven Salicylidene Schiff-Base-Functionalized Artificial Molecular
    Motors.” <i>Nature Communications</i>. Springer Nature, 2024. <a href="https://doi.org/10.1038/s41467-024-50587-4">https://doi.org/10.1038/s41467-024-50587-4</a>.
  ieee: S. Van Vliet, J. Sheng, C. N. Stindt, and B. L. Feringa, “All-visible-light-driven
    salicylidene schiff-base-functionalized artificial molecular motors,” <i>Nature
    Communications</i>, vol. 15. Springer Nature, 2024.
  ista: Van Vliet S, Sheng J, Stindt CN, Feringa BL. 2024. All-visible-light-driven
    salicylidene schiff-base-functionalized artificial molecular motors. Nature Communications.
    15, 6461.
  mla: Van Vliet, Sven, et al. “All-Visible-Light-Driven Salicylidene Schiff-Base-Functionalized
    Artificial Molecular Motors.” <i>Nature Communications</i>, vol. 15, 6461, Springer
    Nature, 2024, doi:<a href="https://doi.org/10.1038/s41467-024-50587-4">10.1038/s41467-024-50587-4</a>.
  short: S. Van Vliet, J. Sheng, C.N. Stindt, B.L. Feringa, Nature Communications
    15 (2024).
das_tickbox: '1'
dataavailabilitystatement: Data that support the findings of this study are available
  within the Supplementary Information. All data are available from the corresponding
  author upon request. The XYZ coordinates of the DFT-optimized structures are available
  as source data. Source data are provided with this paper.
date_created: 2024-08-11T22:01:11Z
date_published: 2024-07-31T00:00:00Z
date_updated: 2026-09-17T10:46:04Z
day: '31'
ddc:
- '540'
department:
- _id: RaKl
doi: 10.1038/s41467-024-50587-4
external_id:
  isi:
  - '001282384300020'
  pmid:
  - '39085193'
file:
- access_level: open_access
  checksum: 4aca2ea30fe529947cb2f4c7fc2af2df
  content_type: application/pdf
  creator: dernst
  date_created: 2024-08-12T08:23:10Z
  date_updated: 2024-08-12T08:23:10Z
  file_id: '17418'
  file_name: 2024_NatureComm_vanVliet.pdf
  file_size: 1355696
  relation: main_file
  success: 1
file_date_updated: 2024-08-12T08:23:10Z
fulldoi: https://doi.org/10.1038/s41467-024-50587-4
has_accepted_license: '1'
intvolume: '        15'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: All-visible-light-driven salicylidene schiff-base-functionalized artificial
  molecular motors
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 15
year: '2024'
...
---
_id: '17105'
abstract:
- lang: eng
  text: The development of photoresponsive systems with non-invasive orthogonal control
    by distinct wavelengths of light is still in its infancy. In particular, the design
    of photochemically triggered-orthogonal systems integrated into solid materials
    that enable multiple dynamic control over their properties remains a longstanding
    challenge. Here, we report the orthogonal and reversible control of two types
    of photoswitches in an integrated solid porous framework, that is, visible-light
    responsive o-fluoroazobenzene and nitro-spiropyran motifs. The properties of the
    constructed material can be selectively controlled by different wavelengths of
    light thus generating four distinct states providing a basis for dynamic multifunctional
    materials. Solid-state NMR spectroscopy demonstrated the selective transformation
    of the azobenzene switch in the bulk, which in turn modulates N2 and CO2 adsorption.
acknowledgement: 'This work was supported from the following sources: China Scholarship
  Council (CSC PhD Fellowship No. 201808330459 to J.S.), the Ministry of Education,
  Culture and Science of the Netherlands (Gravitation Program No. 024.001.035 to BLF),
  Financial support from The Netherlands Organization for Scientific Research (NWO-CW),
  the European Research Council (ERC; advanced Grant No. 694345 to B.L.F.). PRIN (SHERPA
  2020 No. H45F21003430001) and PRIN (HySTAR 2022 No. H53D23004720006) and Lombardy
  Region for “Enhancing Photosynthesis” grant (2021-2023 No. H45F21002830007). W.D.
  is grateful for financial support from Marie Skłodowska-Curie Actions (Individual
  Fellowship No. 101027639). P.C. is grateful for the financial support provided by
  the PRELUDIUM grant from the National Science Center Poland (Reg. No: 2023/49/N/ST5/01864).'
article_number: e202404878
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Jinyu
  full_name: Sheng, Jinyu
  id: 639f0526-27c9-11ee-95a6-966cd7f102d8
  last_name: Sheng
- first_name: Jacopo
  full_name: Perego, Jacopo
  last_name: Perego
- first_name: Silvia
  full_name: Bracco, Silvia
  last_name: Bracco
- first_name: Piotr
  full_name: Cieciórski, Piotr
  last_name: Cieciórski
- first_name: Wojciech
  full_name: Danowski, Wojciech
  last_name: Danowski
- first_name: Angiolina
  full_name: Comotti, Angiolina
  last_name: Comotti
- first_name: Ben L.
  full_name: Feringa, Ben L.
  last_name: Feringa
citation:
  ama: Sheng J, Perego J, Bracco S, et al. Orthogonal photoswitching in a porous organic
    framework. <i>Angewandte Chemie International Edition</i>. 2024;63(23). doi:<a
    href="https://doi.org/10.1002/anie.202404878">10.1002/anie.202404878</a>
  apa: Sheng, J., Perego, J., Bracco, S., Cieciórski, P., Danowski, W., Comotti, A.,
    &#38; Feringa, B. L. (2024). Orthogonal photoswitching in a porous organic framework.
    <i>Angewandte Chemie International Edition</i>. Wiley. <a href="https://doi.org/10.1002/anie.202404878">https://doi.org/10.1002/anie.202404878</a>
  chicago: Sheng, Jinyu, Jacopo Perego, Silvia Bracco, Piotr Cieciórski, Wojciech
    Danowski, Angiolina Comotti, and Ben L. Feringa. “Orthogonal Photoswitching in
    a Porous Organic Framework.” <i>Angewandte Chemie International Edition</i>. Wiley,
    2024. <a href="https://doi.org/10.1002/anie.202404878">https://doi.org/10.1002/anie.202404878</a>.
  ieee: J. Sheng <i>et al.</i>, “Orthogonal photoswitching in a porous organic framework,”
    <i>Angewandte Chemie International Edition</i>, vol. 63, no. 23. Wiley, 2024.
  ista: Sheng J, Perego J, Bracco S, Cieciórski P, Danowski W, Comotti A, Feringa
    BL. 2024. Orthogonal photoswitching in a porous organic framework. Angewandte
    Chemie International Edition. 63(23), e202404878.
  mla: Sheng, Jinyu, et al. “Orthogonal Photoswitching in a Porous Organic Framework.”
    <i>Angewandte Chemie International Edition</i>, vol. 63, no. 23, e202404878, Wiley,
    2024, doi:<a href="https://doi.org/10.1002/anie.202404878">10.1002/anie.202404878</a>.
  short: J. Sheng, J. Perego, S. Bracco, P. Cieciórski, W. Danowski, A. Comotti, B.L.
    Feringa, Angewandte Chemie International Edition 63 (2024).
das_tickbox: '1'
dataavailabilitystatement: The data that support the findings of this study are available
  in the supplementary material of this article.
date_created: 2024-06-03T09:00:01Z
date_published: 2024-03-26T00:00:00Z
date_updated: 2026-09-17T10:32:51Z
day: '26'
ddc:
- '540'
department:
- _id: RaKl
doi: 10.1002/anie.202404878
external_id:
  pmid:
  - '38530132'
file:
- access_level: open_access
  checksum: 7ecb0892051f6ed8f6a6f25baa47543a
  content_type: application/pdf
  creator: dernst
  date_created: 2024-06-03T10:33:17Z
  date_updated: 2024-06-03T10:33:17Z
  file_id: '17107'
  file_name: 2024_AngChemieInt_Sheng.pdf
  file_size: 2363206
  relation: main_file
  success: 1
file_date_updated: 2024-06-03T10:33:17Z
fulldoi: https://doi.org/10.1002/anie.202404878
has_accepted_license: '1'
intvolume: '        63'
issue: '23'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
publication: Angewandte Chemie International Edition
publication_identifier:
  eissn:
  - 1521-3773
  issn:
  - 1433-7851
publication_status: published
publisher: Wiley
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Orthogonal photoswitching in a porous organic framework
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 63
year: '2024'
...
---
OA_place: publisher
OA_type: gold
_id: '17054'
abstract:
- lang: eng
  text: Photoisomerization and photoluminescence are two distinct energy dissipation
    pathways in light-driven molecular motors. The photoisomerization properties of
    discrete molecular motors have been well established in solution, but their photoluminescent
    properties have been rarely reported—especially in aggregates. Here, it is shown
    that an overcrowded alkene-based molecular motor exhibits distinct dynamic properties
    in solution and aggregate states, for example, gel and solid states. Despite the
    poor emissive properties of molecular motors in solution, a bright emission is
    observed in the aggregate states, including in gel and the crystalline solid.
    The emission wavelength is highly dependent on the nature of the supramolecular
    packing and order in the aggregates. As a result, the fluorescent color can be
    readily tuned reversibly via mechanical grinding and vapor fuming, which provides
    a new platform for developing multi-stimuli functional materials.
acknowledgement: This work was supported by the National Natural Science Foundation
  of China (grant nos. 22220102004, 22025503), Shanghai Municipal Science and Technology
  Major Project (grant no. 2018SHZDZX03), the Innovation Program of Shanghai Municipal
  Education Commission (2023ZKZD40), the Fundamental Research Funds for the Central
  Universities, the Program of Introducing Talents of Discipline to Universities (grant
  no. B16017), Science and Technology Commission of Shanghai Municipality (grant no.
  21JC1401700), and the Starry Night Science Fund of Zhejiang University Shanghai
  Institute for Advanced Study (grant no. SN-ZJU-SIAS-006), China Scholarship Council
  (CSC PhD Fellowship No. 202006745016 to Yahan Shan). The authors gratefully acknowledge
  financial support from the Dutch Ministry of Education, Culture and Science (gravitation
  program no. 024.001.035 to Ben L. Feringa). The authors thank Dr. Youxin Fu and
  Dr. Alexander Ryabchun for the help with fluorescence quantum yield measurement,
  Cristina Nitu for the help with photoisomerzation quantum yield measurement, Prof.
  Wesley R. Browne for the help with fluorescence lifetime measurement, and Dr. Jianyu
  Zhang for fruitful discussion and revising the manuscript.
article_number: e584
article_processing_charge: Yes
article_type: original
author:
- first_name: Yahan
  full_name: Shan, Yahan
  last_name: Shan
- first_name: Jinyu
  full_name: Sheng, Jinyu
  id: 639f0526-27c9-11ee-95a6-966cd7f102d8
  last_name: Sheng
- first_name: Qi
  full_name: Zhang, Qi
  last_name: Zhang
- first_name: Marc C.A.
  full_name: Stuart, Marc C.A.
  last_name: Stuart
- first_name: Da Hui
  full_name: Qu, Da Hui
  last_name: Qu
- first_name: Ben L.
  full_name: Feringa, Ben L.
  last_name: Feringa
citation:
  ama: Shan Y, Sheng J, Zhang Q, Stuart MCA, Qu DH, Feringa BL. Multi-state photoluminescent
    properties of an overcrowded alkene-based molecular motor in aggregates. <i>Aggregate</i>.
    2024;5(5). doi:<a href="https://doi.org/10.1002/agt2.584">10.1002/agt2.584</a>
  apa: Shan, Y., Sheng, J., Zhang, Q., Stuart, M. C. A., Qu, D. H., &#38; Feringa,
    B. L. (2024). Multi-state photoluminescent properties of an overcrowded alkene-based
    molecular motor in aggregates. <i>Aggregate</i>. Wiley. <a href="https://doi.org/10.1002/agt2.584">https://doi.org/10.1002/agt2.584</a>
  chicago: Shan, Yahan, Jinyu Sheng, Qi Zhang, Marc C.A. Stuart, Da Hui Qu, and Ben
    L. Feringa. “Multi-State Photoluminescent Properties of an Overcrowded Alkene-Based
    Molecular Motor in Aggregates.” <i>Aggregate</i>. Wiley, 2024. <a href="https://doi.org/10.1002/agt2.584">https://doi.org/10.1002/agt2.584</a>.
  ieee: Y. Shan, J. Sheng, Q. Zhang, M. C. A. Stuart, D. H. Qu, and B. L. Feringa,
    “Multi-state photoluminescent properties of an overcrowded alkene-based molecular
    motor in aggregates,” <i>Aggregate</i>, vol. 5, no. 5. Wiley, 2024.
  ista: Shan Y, Sheng J, Zhang Q, Stuart MCA, Qu DH, Feringa BL. 2024. Multi-state
    photoluminescent properties of an overcrowded alkene-based molecular motor in
    aggregates. Aggregate. 5(5), e584.
  mla: Shan, Yahan, et al. “Multi-State Photoluminescent Properties of an Overcrowded
    Alkene-Based Molecular Motor in Aggregates.” <i>Aggregate</i>, vol. 5, no. 5,
    e584, Wiley, 2024, doi:<a href="https://doi.org/10.1002/agt2.584">10.1002/agt2.584</a>.
  short: Y. Shan, J. Sheng, Q. Zhang, M.C.A. Stuart, D.H. Qu, B.L. Feringa, Aggregate
    5 (2024).
das_tickbox: '0'
date_created: 2024-05-26T22:00:58Z
date_published: 2024-10-01T00:00:00Z
date_updated: 2026-09-17T11:01:40Z
day: '01'
ddc:
- '540'
department:
- _id: RaKl
doi: 10.1002/agt2.584
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quality_controlled: '1'
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title: Multi-state photoluminescent properties of an overcrowded alkene-based molecular
  motor in aggregates
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- first_name: Merima
  full_name: Smajlhodžić-Deljo, Merima
  last_name: Smajlhodžić-Deljo
- first_name: Lejla
  full_name: Gurbeta Pokvic, Lejla
  last_name: Gurbeta Pokvic
- first_name: Bettina
  full_name: Bert, Bettina
  last_name: Bert
- first_name: Nataliia
  full_name: Bubalo, Nataliia
  last_name: Bubalo
- first_name: Sevilay
  full_name: Erden, Sevilay
  last_name: Erden
- first_name: Nuno Henrique
  full_name: Franco, Nuno Henrique
  last_name: Franco
- first_name: Giuseppe
  full_name: Chirico, Giuseppe
  last_name: Chirico
- first_name: Jonathan
  full_name: Gómez Raja, Jonathan
  last_name: Gómez Raja
- first_name: Fernando
  full_name: Gonzalez-Uarquin, Fernando
  last_name: Gonzalez-Uarquin
- first_name: Annemarie
  full_name: Lang, Annemarie
  last_name: Lang
- first_name: Nicole
  full_name: Linklater, Nicole
  last_name: Linklater
- first_name: Sandra
  full_name: Mojsova, Sandra
  last_name: Mojsova
- first_name: I. Anna S.
  full_name: Olsson, I. Anna S.
  last_name: Olsson
- first_name: Ioanna
  full_name: Sandvig, Ioanna
  last_name: Sandvig
- first_name: Alexandra
  full_name: Schaffert, Alexandra
  last_name: Schaffert
- first_name: Marthe
  full_name: Schmit, Marthe
  last_name: Schmit
- first_name: Sophie
  full_name: Schober, Sophie
  id: 80b0a0ef-4b9f-11ec-b119-8d9d94c4a1d8
  last_name: Schober
- first_name: Bogdan
  full_name: Sevastre, Bogdan
  last_name: Sevastre
- first_name: Doris
  full_name: Wilflingseder, Doris
  last_name: Wilflingseder
- first_name: Arti
  full_name: Ahluwalia, Arti
  last_name: Ahluwalia
- first_name: Winfried
  full_name: Neuhaus, Winfried
  last_name: Neuhaus
citation:
  ama: Kitsara M, Smajlhodžić-Deljo M, Gurbeta Pokvic L, et al. Introducing the COST
    action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE).
    <i>Alternatives to Laboratory Animals</i>. 2024;52(6):326-333. doi:<a href="https://doi.org/10.1177/02611929241286024">10.1177/02611929241286024</a>
  apa: Kitsara, M., Smajlhodžić-Deljo, M., Gurbeta Pokvic, L., Bert, B., Bubalo, N.,
    Erden, S., … Neuhaus, W. (2024). Introducing the COST action ‘Improving the Quality
    of Biomedical Science with 3Rs Concepts’ (IMPROVE). <i>Alternatives to Laboratory
    Animals</i>. SAGE Publications. <a href="https://doi.org/10.1177/02611929241286024">https://doi.org/10.1177/02611929241286024</a>
  chicago: Kitsara, Maria, Merima Smajlhodžić-Deljo, Lejla Gurbeta Pokvic, Bettina
    Bert, Nataliia Bubalo, Sevilay Erden, Nuno Henrique Franco, et al. “Introducing
    the COST Action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’
    (IMPROVE).” <i>Alternatives to Laboratory Animals</i>. SAGE Publications, 2024.
    <a href="https://doi.org/10.1177/02611929241286024">https://doi.org/10.1177/02611929241286024</a>.
  ieee: M. Kitsara <i>et al.</i>, “Introducing the COST action ‘Improving the Quality
    of Biomedical Science with 3Rs Concepts’ (IMPROVE),” <i>Alternatives to Laboratory
    Animals</i>, vol. 52, no. 6. SAGE Publications, pp. 326–333, 2024.
  ista: Kitsara M, Smajlhodžić-Deljo M, Gurbeta Pokvic L, Bert B, Bubalo N, Erden
    S, Franco NH, Chirico G, Gómez Raja J, Gonzalez-Uarquin F, Lang A, Linklater N,
    Mojsova S, Olsson IAS, Sandvig I, Schaffert A, Schmit M, Schober S, Sevastre B,
    Wilflingseder D, Ahluwalia A, Neuhaus W. 2024. Introducing the COST action ‘Improving
    the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE). Alternatives to
    Laboratory Animals. 52(6), 326–333.
  mla: Kitsara, Maria, et al. “Introducing the COST Action ‘Improving the Quality
    of Biomedical Science with 3Rs Concepts’ (IMPROVE).” <i>Alternatives to Laboratory
    Animals</i>, vol. 52, no. 6, SAGE Publications, 2024, pp. 326–33, doi:<a href="https://doi.org/10.1177/02611929241286024">10.1177/02611929241286024</a>.
  short: M. Kitsara, M. Smajlhodžić-Deljo, L. Gurbeta Pokvic, B. Bert, N. Bubalo,
    S. Erden, N.H. Franco, G. Chirico, J. Gómez Raja, F. Gonzalez-Uarquin, A. Lang,
    N. Linklater, S. Mojsova, I.A.S. Olsson, I. Sandvig, A. Schaffert, M. Schmit,
    S. Schober, B. Sevastre, D. Wilflingseder, A. Ahluwalia, W. Neuhaus, Alternatives
    to Laboratory Animals 52 (2024) 326–333.
das_tickbox: '0'
date_created: 2024-10-13T22:01:51Z
date_published: 2024-11-01T00:00:00Z
date_updated: 2026-09-17T10:30:08Z
day: '01'
department:
- _id: PreCl
doi: 10.1177/02611929241286024
external_id:
  isi:
  - '001348633700007'
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  - '39333027'
fulldoi: https://doi.org/10.1177/02611929241286024
intvolume: '        52'
isi: 1
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language:
- iso: eng
month: '11'
oa_version: None
page: 326-333
pmid: 1
publication: Alternatives to Laboratory Animals
publication_identifier:
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  issn:
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publication_status: published
publisher: SAGE Publications
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Introducing the COST action ‘Improving the Quality of Biomedical Science with
  3Rs Concepts’ (IMPROVE)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 52
year: '2024'
...
---
_id: '15318'
abstract:
- lang: eng
  text: We consider a gas of N weakly interacting bosons in the ground state. Such
    gases exhibit Bose–Einstein condensation. The binding energy is defined as the
    energy it takes to remove one particle from the gas. In this article, we prove
    an asymptotic expansion for the binding energy, and compute the first orders explicitly
    for the homogeneous gas. Our result addresses in particular a conjecture by Nam
    (Lett Math Phys 108(1):141–159, 2018), and provides an asymptotic expansion of
    the ionization energy of bosonic atoms.
acknowledgement: "It is a pleasure to thank Phan Thành Nam for helpful discussions
  on bosonic atoms. L.B. was supported by the German Research Foundation within the
  Munich Center of Quantum Science and Technology (EXC 2111). N.L. gratefully acknowledges
  support from the Swiss National Science Foundation through the NCCR SwissMap and
  funding from the European Union’s Horizon 2020 research and innovation programme
  under the Marie Skłodowska-Curie Grant agreement No 101024712. S.P. acknowledges
  funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)—Project
  number 512258249.\r\nOpen Access funding enabled and organized by Projekt DEAL."
article_number: '48'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Lea
  full_name: Bossmann, Lea
  id: A2E3BCBE-5FCC-11E9-AA4B-76F3E5697425
  last_name: Bossmann
  orcid: 0000-0002-6854-1343
- first_name: Nikolai K
  full_name: Leopold, Nikolai K
  id: 4BC40BEC-F248-11E8-B48F-1D18A9856A87
  last_name: Leopold
  orcid: 0000-0002-0495-6822
- first_name: David Johannes
  full_name: Mitrouskas, David Johannes
  id: cbddacee-2b11-11eb-a02e-a2e14d04e52d
  last_name: Mitrouskas
- first_name: Sören P
  full_name: Petrat, Sören P
  id: 40AC02DC-F248-11E8-B48F-1D18A9856A87
  last_name: Petrat
  orcid: 0000-0002-9166-5889
citation:
  ama: Bossmann L, Leopold NK, Mitrouskas DJ, Petrat SP. A note on the binding energy
    for Bosons in the mean-field limit. <i>Journal of Statistical Physics</i>. 2024;191(4).
    doi:<a href="https://doi.org/10.1007/s10955-024-03260-5">10.1007/s10955-024-03260-5</a>
  apa: Bossmann, L., Leopold, N. K., Mitrouskas, D. J., &#38; Petrat, S. P. (2024).
    A note on the binding energy for Bosons in the mean-field limit. <i>Journal of
    Statistical Physics</i>. Springer Nature. <a href="https://doi.org/10.1007/s10955-024-03260-5">https://doi.org/10.1007/s10955-024-03260-5</a>
  chicago: Bossmann, Lea, Nikolai K Leopold, David Johannes Mitrouskas, and Sören
    P Petrat. “A Note on the Binding Energy for Bosons in the Mean-Field Limit.” <i>Journal
    of Statistical Physics</i>. Springer Nature, 2024. <a href="https://doi.org/10.1007/s10955-024-03260-5">https://doi.org/10.1007/s10955-024-03260-5</a>.
  ieee: L. Bossmann, N. K. Leopold, D. J. Mitrouskas, and S. P. Petrat, “A note on
    the binding energy for Bosons in the mean-field limit,” <i>Journal of Statistical
    Physics</i>, vol. 191, no. 4. Springer Nature, 2024.
  ista: Bossmann L, Leopold NK, Mitrouskas DJ, Petrat SP. 2024. A note on the binding
    energy for Bosons in the mean-field limit. Journal of Statistical Physics. 191(4),
    48.
  mla: Bossmann, Lea, et al. “A Note on the Binding Energy for Bosons in the Mean-Field
    Limit.” <i>Journal of Statistical Physics</i>, vol. 191, no. 4, 48, Springer Nature,
    2024, doi:<a href="https://doi.org/10.1007/s10955-024-03260-5">10.1007/s10955-024-03260-5</a>.
  short: L. Bossmann, N.K. Leopold, D.J. Mitrouskas, S.P. Petrat, Journal of Statistical
    Physics 191 (2024).
das_tickbox: '1'
dataavailabilitystatement: Data sharing not applicable to this article as no datasets
  were generated or analyzed during the current study.
date_created: 2024-04-14T22:01:02Z
date_published: 2024-04-06T00:00:00Z
date_updated: 2026-09-17T11:05:18Z
day: '06'
ddc:
- '510'
department:
- _id: RoSe
doi: 10.1007/s10955-024-03260-5
external_id:
  arxiv:
  - '2307.13115'
  isi:
  - '001197663100002'
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isi: 1
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language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
publication: Journal of Statistical Physics
publication_identifier:
  eissn:
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  issn:
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publication_status: published
publisher: Springer Nature
quality_controlled: '1'
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status: public
supplementarymaterial: no
title: A note on the binding energy for Bosons in the mean-field limit
tmp:
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  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 191
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...
