--- OA_place: repository OA_type: green _id: '19063' abstract: - lang: eng text: "Instruction-tuned Large Language Models (LLMs) show impressive results in numerous practical applications, but they lack essential safety features that are common in other areas of computer science, particularly an explicit separation of instructions and data. This makes them vulnerable to manipulations such as indirect prompt injections and generally unsuitable for safety-critical tasks. Surprisingly, there is currently no established definition or benchmark to quantify this phenomenon. In this work, we close this gap by introducing a formal measure for instruction-data separation and an empirical variant that is calculable from a model's outputs. We also present a new dataset, SEP, that allows estimating the measure for real-world models. Our results on various LLMs show that the problem of instruction-data separation is real: all models fail to achieve high separation, and canonical mitigation techniques, such as prompt engineering and fine-tuning, either fail to substantially improve separation or reduce model utility. The source code and SEP dataset are openly accessible at https://github.com/egozverev/Shold-It-Be-Executed-Or-Processed.\r\n" acknowledged_ssus: - _id: ScienComp acknowledgement: The authors would like to sincerely thank Juan Rocamonde for valuable feedback to our manuscript. We acknowledge the support from the Scientific Service Units (SSU) of ISTA through resources provided by Scientific Computing (SciComp). We thank Dan Alistarh for providing us with computational resources. This work was partially funded by the German Federal Ministry of Education and Research (BMBF) under the grant AIgenCY (16KIS2012) and ELSA – European Lighthouse on Secure and Safe AI funded by the European Union under grant agreement No. 101070617. Views and opinions expressed are however those of the authors only and do not necessarily reflect those of the European Union or European Commission. Neither the European Union nor the European Commission can be held responsible for them. article_number: '2403.06833' article_processing_charge: No arxiv: 1 author: - first_name: Egor full_name: Zverev, Egor id: 05162b19-1340-11ed-8f02-fa94e0e8c3bc last_name: Zverev - first_name: Sahar full_name: Abdelnabi, Sahar last_name: Abdelnabi - first_name: Soroush full_name: Tabesh, Soroush id: 06000900-6068-11ef-8d61-c2472ef2e752 last_name: Tabesh orcid: 0009-0003-4119-6281 - first_name: Mario full_name: Fritz, Mario last_name: Fritz - first_name: Christoph full_name: Lampert, Christoph id: 40C20FD2-F248-11E8-B48F-1D18A9856A87 last_name: Lampert orcid: 0000-0001-8622-7887 citation: ama: Zverev E, Abdelnabi S, Tabesh S, Fritz M, Lampert C. Can LLMs separate instructions from data? And what do we even mean by that? arXiv. doi:10.48550/arXiv.2403.06833 apa: Zverev, E., Abdelnabi, S., Tabesh, S., Fritz, M., & Lampert, C. (n.d.). Can LLMs separate instructions from data? And what do we even mean by that? arXiv. https://doi.org/10.48550/arXiv.2403.06833 chicago: Zverev, Egor, Sahar Abdelnabi, Soroush Tabesh, Mario Fritz, and Christoph Lampert. “Can LLMs Separate Instructions from Data? And What Do We Even Mean by That?” ArXiv, n.d. https://doi.org/10.48550/arXiv.2403.06833. ieee: E. Zverev, S. Abdelnabi, S. Tabesh, M. Fritz, and C. Lampert, “Can LLMs separate instructions from data? And what do we even mean by that?,” arXiv. . ista: Zverev E, Abdelnabi S, Tabesh S, Fritz M, Lampert C. Can LLMs separate instructions from data? And what do we even mean by that? arXiv, 2403.06833. mla: Zverev, Egor, et al. “Can LLMs Separate Instructions from Data? And What Do We Even Mean by That?” ArXiv, 2403.06833, doi:10.48550/arXiv.2403.06833. short: E. Zverev, S. Abdelnabi, S. Tabesh, M. Fritz, C. Lampert, ArXiv (n.d.). corr_author: '1' date_created: 2025-02-20T10:13:42Z date_published: 2024-03-01T00:00:00Z date_updated: 2026-08-13T07:26:54Z day: '01' ddc: - '000' department: - _id: GradSch - _id: ChLa doi: 10.48550/arXiv.2403.06833 external_id: arxiv: - '2403.06833' file: - access_level: open_access checksum: 35eb43968684b87be59144603ef10af0 content_type: application/pdf creator: ezverev date_created: 2025-02-20T10:11:45Z date_updated: 2025-02-20T10:11:45Z file_id: '19064' file_name: 2403.06833v3.pdf file_size: 530972 relation: main_file success: 1 file_date_updated: 2025-02-20T10:11:45Z fulldoi: https://doi.org/10.48550/arXiv.2403.06833 has_accepted_license: '1' language: - iso: eng license: https://creativecommons.org/licenses/by/4.0/ month: '03' oa: 1 oa_version: Preprint publication: arXiv publication_status: submitted related_material: link: - relation: software url: ' https://github.com/egozverev/Shold-It-Be-Executed-Or-Processed' status: public title: Can LLMs separate instructions from data? And what do we even mean by that? tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: preprint user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2024' ... --- _id: '17161' abstract: - lang: eng text: Dynamic processes in molecules can occur on a wide range of timescales, and it is important to understand which timescales of motion contribute to different parameters used in dynamics measurements. For spin relaxation, this can easily be understood from the sampling frequencies of the spectral-density function by different relaxation-rate constants. In addition to data from relaxation measurements, determining dynamically averaged anisotropic interactions in magic-angle spinning (MAS) solid-state NMR allows for better quantification of the amplitude of molecular motion. For partially averaged anisotropic interactions, the relevant timescales of motion are not so clearly defined. Whether the averaging depends on the experimental methods (e.g., pulse sequences) or conditions (e.g., MAS frequency, magnitude of anisotropic interaction, radio-frequency field amplitudes) is not fully understood. To investigate these questions, we performed numerical simulations of dynamic systems based on the stochastic Liouville equation using several experiments for recoupling the dipolar coupling, chemical-shift anisotropy or quadrupolar coupling. As described in the literature, the transition between slow motion, where parameters characterizing the anisotropic interaction are not averaged, and fast motion, where the tensors are averaged leading to a scaled anisotropic quantity, occurs over a window of motional rate constants that depends mainly on the strength of the interaction. This transition region can span 2 orders of magnitude in exchange-rate constants (typically in the microsecond range) but depends only marginally on the employed recoupling scheme or sample spinning frequency. The transition region often coincides with a fast relaxation of coherences, making precise quantitative measurements difficult. Residual couplings in off-magic-angle experiments, however, average over longer timescales of motion. While in principle one may gain information on the timescales of motion from the transition area, extracting such information is hampered by low signal-to-noise ratio in experimental spectra due to fast relaxation that occurs in the same region. acknowledgement: "We would like to thank Kay Saalwächter for pointing out important aspects of the intermediate regime during the open review process. Lea Marie Becker is recipient of a DOC fellowship of the Austrian Academy of Sciences at the Institute of Science and Technology Austria.\r\nThis research has been supported by the Österreichischen Akademie der Wissenschaften (grant no. PR10660EAW01) and the Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (grant nos. 200020_188988 and 200020_219375)." article_processing_charge: Yes article_type: original author: - first_name: Kathrin full_name: Aebischer, Kathrin last_name: Aebischer - first_name: Lea Marie full_name: Becker, Lea Marie id: 36336939-eb97-11eb-a6c2-c83f1214ca79 last_name: Becker orcid: 0000-0002-6401-5151 - first_name: Paul full_name: Schanda, Paul id: 7B541462-FAF6-11E9-A490-E8DFE5697425 last_name: Schanda orcid: 0000-0002-9350-7606 - first_name: Matthias full_name: Ernst, Matthias last_name: Ernst citation: ama: Aebischer K, Becker LM, Schanda P, Ernst M. Evaluating the motional timescales contributing to averaged anisotropic interactions in MAS solid-state NMR. Magnetic Resonance. 2024;5(1):69-86. doi:10.5194/mr-5-69-2024 apa: Aebischer, K., Becker, L. M., Schanda, P., & Ernst, M. (2024). Evaluating the motional timescales contributing to averaged anisotropic interactions in MAS solid-state NMR. Magnetic Resonance. Copernicus Publications. https://doi.org/10.5194/mr-5-69-2024 chicago: Aebischer, Kathrin, Lea Marie Becker, Paul Schanda, and Matthias Ernst. “Evaluating the Motional Timescales Contributing to Averaged Anisotropic Interactions in MAS Solid-State NMR.” Magnetic Resonance. Copernicus Publications, 2024. https://doi.org/10.5194/mr-5-69-2024. ieee: K. Aebischer, L. M. Becker, P. Schanda, and M. Ernst, “Evaluating the motional timescales contributing to averaged anisotropic interactions in MAS solid-state NMR,” Magnetic Resonance, vol. 5, no. 1. Copernicus Publications, pp. 69–86, 2024. ista: Aebischer K, Becker LM, Schanda P, Ernst M. 2024. Evaluating the motional timescales contributing to averaged anisotropic interactions in MAS solid-state NMR. Magnetic Resonance. 5(1), 69–86. mla: Aebischer, Kathrin, et al. “Evaluating the Motional Timescales Contributing to Averaged Anisotropic Interactions in MAS Solid-State NMR.” Magnetic Resonance, vol. 5, no. 1, Copernicus Publications, 2024, pp. 69–86, doi:10.5194/mr-5-69-2024. short: K. Aebischer, L.M. Becker, P. Schanda, M. Ernst, Magnetic Resonance 5 (2024) 69–86. date_created: 2024-06-23T22:01:02Z date_published: 2024-06-11T00:00:00Z date_updated: 2026-09-11T08:49:55Z day: '11' ddc: - '530' department: - _id: PaSc doi: 10.5194/mr-5-69-2024 external_id: pmid: - '40384772' file: - access_level: open_access checksum: d01074f6919387fcaf8c9ebed320ccae content_type: application/pdf creator: dernst date_created: 2024-06-27T06:42:55Z date_updated: 2024-06-27T06:42:55Z file_id: '17181' file_name: 2024_MagneticResonance_Aebischer.pdf file_size: 6736194 relation: main_file success: 1 file_date_updated: 2024-06-27T06:42:55Z fulldoi: https://doi.org/10.5194/mr-5-69-2024 has_accepted_license: '1' intvolume: ' 5' issue: '1' language: - iso: eng month: '06' oa: 1 oa_version: Published Version page: 69-86 pmid: 1 project: - _id: 7be609c4-9f16-11ee-852c-85015ce2b9b0 grant_number: '26777' name: Exploring protein dynamics by solid-state MAS NMR through specific labeling approaches publication: Magnetic Resonance publication_identifier: eissn: - 2699-0016 publication_status: published publisher: Copernicus Publications quality_controlled: '1' related_material: record: - id: '22906' relation: research_data status: public scopus_import: '1' status: public title: Evaluating the motional timescales contributing to averaged anisotropic interactions in MAS solid-state NMR tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 5 year: '2024' ... --- OA_place: repository OA_type: green _id: '22906' article_processing_charge: No author: - first_name: Kathrin full_name: Aebischer, Kathrin last_name: Aebischer citation: ama: Aebischer K. Evaluating the motional time scales contributing to averaged anisotropic interactions in MAS solid-state NMR. 2024. doi:10.3929/ethz-b-000666765 apa: Aebischer, K. (2024). Evaluating the motional time scales contributing to averaged anisotropic interactions in MAS solid-state NMR. Repository. https://doi.org/10.3929/ethz-b-000666765 chicago: Aebischer, Kathrin. “Evaluating the Motional Time Scales Contributing to Averaged Anisotropic Interactions in MAS Solid-State NMR.” Repository, 2024. https://doi.org/10.3929/ethz-b-000666765. ieee: K. Aebischer, “Evaluating the motional time scales contributing to averaged anisotropic interactions in MAS solid-state NMR.” Repository, 2024. ista: Aebischer K. 2024. Evaluating the motional time scales contributing to averaged anisotropic interactions in MAS solid-state NMR, Repository, 10.3929/ethz-b-000666765. mla: Aebischer, Kathrin. Evaluating the Motional Time Scales Contributing to Averaged Anisotropic Interactions in MAS Solid-State NMR. Repository, 2024, doi:10.3929/ethz-b-000666765. short: K. Aebischer, (2024). contributor: - contributor_type: contact_person first_name: Matthias last_name: Ernst - contributor_type: data_collector first_name: Kathrin last_name: Aebischer - contributor_type: data_collector first_name: Matthias last_name: Ernst - contributor_type: data_collector first_name: Paul last_name: Schanda - contributor_type: data_collector first_name: Lea Marie last_name: Becker - contributor_type: producer first_name: Matthias last_name: ' Ernst' - contributor_type: producer first_name: Kathrin last_name: ' Aebischer' - contributor_type: producer first_name: 'Paul ' last_name: Schanda - contributor_type: producer first_name: Lea Marie last_name: Becker date_created: 2026-09-11T08:49:48Z date_published: 2024-04-03T00:00:00Z date_updated: 2026-09-11T08:49:55Z day: '03' ddc: - '530' department: - _id: PaSc doi: 10.3929/ethz-b-000666765 fulldoi: https://doi.org/10.3929/ethz-b-000666765 main_file_link: - open_access: '1' url: https://doi.org/10.3929/ethz-b-000666765 month: '04' oa: 1 oa_version: None publisher: Repository related_material: record: - id: '17161' relation: used_in_publication status: public status: public title: Evaluating the motional time scales contributing to averaged anisotropic interactions in MAS solid-state NMR type: research_data_reference user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 year: '2024' ... --- APC_amount: 6248,82 EUR DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '18603' abstract: - lang: eng text: It is widely believed that information storage in neuronal circuits involves nanoscopic structural changes at synapses, resulting in the formation of synaptic engrams. However, direct evidence for this hypothesis is lacking. To test this conjecture, we combined chemical potentiation, functional analysis by paired pre-postsynaptic recordings, and structural analysis by electron microscopy (EM) and freeze-fracture replica labeling (FRL) at the rodent hippocampal mossy fiber synapse, a key synapse in the trisynaptic circuit of the hippocampus. Biophysical analysis of synaptic transmission revealed that forskolin-induced chemical potentiation increased the readily releasable vesicle pool size and vesicular release probability by 146% and 49%, respectively. Structural analysis of mossy fiber synapses by EM and FRL demonstrated an increase in the number of vesicles close to the plasma membrane and the number of clusters of the priming protein Munc13-1, indicating an increase in the number of both docked and primed vesicles. Furthermore, FRL analysis revealed a significant reduction of the distance between Munc13-1 and CaV2.1 Ca2+ channels, suggesting reconfiguration of the channel-vesicle coupling nanotopography. Our results indicate that presynaptic plasticity is associated with structural reorganization of active zones. We propose that changes in potential nanoscopic organization at synaptic vesicle release sites may be correlates of learning and memory at a plastic central synapse. acknowledged_ssus: - _id: EM-Fac - _id: PreCl acknowledgement: "We thank Carolina Borges-Merjane, Jing-Jing Chen, Katharina Lichter, and Samuel Young for critically reading the manuscript; the Electron Microscopy Facility of ISTA, in particular Vanessa Zheden, for extensive support, advice, and experimental assistance; the Preclinical Facility of ISTA, in particular Victoria Wimmer and Michael Schunn, for experimental assistance; Florian Marr and Christina Altmutter for technical support; Alois Schlögl for help with analysis; and Eleftheria Kralli-Beller for manuscript editing. We also thank Cordelia Imig for providing Munc13-1cKO-Munc13-2/3(−/−) mutant mice. Part of the work has been published in O.K.’s thesis in partial fulfillment of the requirements for the degree of Doctor of Philosophy.\r\nThis project received funding from the European Research Council and European Union’s Horizon 2020 research and innovation programme (ERC 692692 to P.J.; https://cordis.europa.eu/project/id/692692/de) and from the Fond zur Förderung der Wissenschaftlichen Forschung (Z312-B27 Wittgenstein award to P.J., https://www.fwf.ac.at/en/funding/portfolio/projects/fwf-wittgenstein-award; W1205-B09 and P36232-B to P.J., https://www.fwf.ac.at/en/funding; I6166-B to R.S.; https://www.fwf.ac.at/en/funding). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript." article_number: e3002879 article_processing_charge: Yes article_type: original author: - first_name: Olena full_name: Kim, Olena id: 3F8ABDDA-F248-11E8-B48F-1D18A9856A87 last_name: Kim orcid: 0000-0003-2344-1039 - first_name: Yuji full_name: Okamoto, Yuji id: 3337E116-F248-11E8-B48F-1D18A9856A87 last_name: Okamoto orcid: 0000-0003-0408-6094 - first_name: Walter full_name: Kaufmann, Walter id: 3F99E422-F248-11E8-B48F-1D18A9856A87 last_name: Kaufmann orcid: 0000-0001-9735-5315 - first_name: Nils full_name: Brose, Nils last_name: Brose - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 citation: ama: Kim O, Okamoto Y, Kaufmann W, Brose N, Shigemoto R, Jonas PM. Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons. PLoS Biology. 2024;22(11). doi:10.1371/journal.pbio.3002879 apa: Kim, O., Okamoto, Y., Kaufmann, W., Brose, N., Shigemoto, R., & Jonas, P. M. (2024). Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons. PLoS Biology. Public Library of Science. https://doi.org/10.1371/journal.pbio.3002879 chicago: Kim, Olena, Yuji Okamoto, Walter Kaufmann, Nils Brose, Ryuichi Shigemoto, and Peter M Jonas. “Presynaptic CAMP-PKA-Mediated Potentiation Induces Reconfiguration of Synaptic Vesicle Pools and Channel-Vesicle Coupling at Hippocampal Mossy Fiber Boutons.” PLoS Biology. Public Library of Science, 2024. https://doi.org/10.1371/journal.pbio.3002879. ieee: O. Kim, Y. Okamoto, W. Kaufmann, N. Brose, R. Shigemoto, and P. M. Jonas, “Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons,” PLoS Biology, vol. 22, no. 11. Public Library of Science, 2024. ista: Kim O, Okamoto Y, Kaufmann W, Brose N, Shigemoto R, Jonas PM. 2024. Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons. PLoS Biology. 22(11), e3002879. mla: Kim, Olena, et al. “Presynaptic CAMP-PKA-Mediated Potentiation Induces Reconfiguration of Synaptic Vesicle Pools and Channel-Vesicle Coupling at Hippocampal Mossy Fiber Boutons.” PLoS Biology, vol. 22, no. 11, e3002879, Public Library of Science, 2024, doi:10.1371/journal.pbio.3002879. short: O. Kim, Y. Okamoto, W. Kaufmann, N. Brose, R. Shigemoto, P.M. Jonas, PLoS Biology 22 (2024). corr_author: '1' date_created: 2024-12-01T23:01:54Z date_published: 2024-11-18T00:00:00Z date_updated: 2026-04-16T12:20:34Z day: '18' ddc: - '570' department: - _id: PeJo - _id: EM-Fac - _id: RySh doi: 10.1371/journal.pbio.3002879 ec_funded: 1 external_id: isi: - '001358568700003' pmid: - '39556620' file: - access_level: open_access checksum: 7de2dcb50deb65dde05c80082bb85a82 content_type: application/pdf creator: dernst date_created: 2024-12-03T08:56:53Z date_updated: 2024-12-03T08:56:53Z file_id: '18608' file_name: 2024_PloSBio_Kim.pdf file_size: 3057631 relation: main_file success: 1 file_date_updated: 2024-12-03T08:56:53Z fulldoi: https://doi.org/10.1371/journal.pbio.3002879 has_accepted_license: '1' intvolume: ' 22' isi: 1 issue: '11' language: - iso: eng month: '11' oa: 1 oa_version: Published Version pmid: 1 project: - _id: 25B7EB9E-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '692692' name: Biophysics and circuit function of a giant cortical glutamatergic synapse - _id: 25C5A090-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: Z00312 name: Synaptic communication in neuronal microcircuits - _id: bd88be38-d553-11ed-ba76-81d5a70a6ef5 grant_number: P36232 name: Mechanisms of GABA release in hippocampal circuits - _id: b1b85715-d554-11ed-a5ad-84a07fc9f18e grant_number: I06166 name: Structural & functional basis of presynaptic plasticity - _id: 25C3DBB6-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: W01205 name: Zellkommunikation in Gesundheit und Krankheit - _id: 3AC91DDA-15DF-11EA-824D-93A3E7B544D1 call_identifier: FWF name: FWF Open Access Fund publication: PLoS Biology publication_identifier: eissn: - 1545-7885 issn: - 1544-9173 publication_status: published publisher: Public Library of Science quality_controlled: '1' related_material: record: - id: '18296' relation: research_data status: public scopus_import: '1' status: public title: Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 22 year: '2024' ... --- _id: '18296' abstract: - lang: eng text: It is widely believed that information storage in neuronal circuits involves nanoscopic structural changes at synapses, resulting in the formation of synaptic engrams. However, direct evidence for this hypothesis is lacking. To test this conjecture, we combined chemical potentiation, functional analysis by paired pre-postsynaptic recordings, and structural analysis by electron microscopy (EM) and freeze-fracture replica labeling (FRL) at the murine hippocampal mossy fiber synapse, a key synapse in the trisynaptic circuit of the hippocampus. Biophysical analysis of synaptic transmission revealed that forskolin-induced chemical potentiation increased the readily releasable vesicle pool size and vesicular release probability by 146% and 49%, respectively. Structural analysis of mossy fiber synapses by EM and FRL demonstrated an increase in the number of vesicles close to the plasma membrane and the number of clusters of the priming protein Munc13-1, indicating an increase in the number of both docked and primed vesicles. Furthermore, FRL analysis revealed a significant reduction of the distance between Munc13-1 and CaV2.1 Ca2+ channels, suggesting reconfiguration of the channel-vesicle coupling nanotopography. Our results indicate that presynaptic plasticity is associated with structural reorganization of active zones. We propose that changes in potential nanoscopic organization at synaptic vesicle release sites may be correlates of learning and memory at a plastic central synapse. article_processing_charge: No author: - first_name: Olena full_name: Kim, Olena id: 3F8ABDDA-F248-11E8-B48F-1D18A9856A87 last_name: Kim orcid: 0000-0003-2344-1039 citation: ama: Kim O. Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons. 2024. doi:10.15479/AT:ISTA:18296 apa: Kim, O. (2024). Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:18296 chicago: Kim, Olena. “Presynaptic CAMP-PKA-Mediated Potentiation Induces Reconfiguration of Synaptic Vesicle Pools and Channel-Vesicle Coupling at Hippocampal Mossy Fiber Boutons.” Institute of Science and Technology Austria, 2024. https://doi.org/10.15479/AT:ISTA:18296. ieee: O. Kim, “Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons.” Institute of Science and Technology Austria, 2024. ista: Kim O. 2024. Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons, Institute of Science and Technology Austria, 10.15479/AT:ISTA:18296. mla: Kim, Olena. Presynaptic CAMP-PKA-Mediated Potentiation Induces Reconfiguration of Synaptic Vesicle Pools and Channel-Vesicle Coupling at Hippocampal Mossy Fiber Boutons. Institute of Science and Technology Austria, 2024, doi:10.15479/AT:ISTA:18296. short: O. Kim, (2024). contributor: - contributor_type: researcher first_name: Olena id: 3F8ABDDA-F248-11E8-B48F-1D18A9856A87 last_name: Kim - contributor_type: researcher first_name: Yuji id: 3337E116-F248-11E8-B48F-1D18A9856A87 last_name: Okamoto orcid: 0000-0003-0408-6094 - contributor_type: researcher first_name: Walter id: 3F99E422-F248-11E8-B48F-1D18A9856A87 last_name: Kaufmann orcid: 0000-0001-9735-5315 - contributor_type: researcher first_name: 'Nils ' last_name: Brose - contributor_type: researcher first_name: Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - contributor_type: supervisor first_name: Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 corr_author: '1' date_created: 2024-10-11T10:12:17Z date_published: 2024-10-11T00:00:00Z date_updated: 2026-09-14T08:48:01Z day: '11' ddc: - '570' department: - _id: PeJo - _id: RySh - _id: EM-Fac doi: 10.15479/AT:ISTA:18296 ec_funded: 1 file: - access_level: open_access checksum: 0a977e7df54c418251b10dfd3f8a015c content_type: application/zip creator: okim date_created: 2024-10-11T10:04:19Z date_updated: 2024-10-11T10:04:19Z file_id: '18297' file_name: Kim_et_al_2024_PlosBio_Source_data.zip file_size: 164382 relation: main_file success: 1 - access_level: open_access checksum: 5b9343d6b2035ac3185e390fad4d3830 content_type: text/plain creator: okim date_created: 2024-10-11T10:04:23Z date_updated: 2024-10-11T10:04:23Z file_id: '18298' file_name: info.txt file_size: 654 relation: main_file success: 1 file_date_updated: 2024-10-11T10:04:23Z fulldoi: https://doi.org/10.15479/AT:ISTA:18296 has_accepted_license: '1' keyword: - Hippocampal mossy fiber synapses - short-term potentiation - long-term potentiation - presynaptic plasticity - electron microscopy - freeze-fracture replica labeling - paired recordings - forskolin - cyclic adenosine monophosphate (cAMP) - protein kinase A (PKA) - neuromodulation - synaptic vesicle pools - presynaptic Ca2+ channels - Munc13 - docking - priming - active zone month: '10' oa: 1 oa_version: Submitted Version project: - _id: 25B7EB9E-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '692692' name: Biophysics and circuit function of a giant cortical glutamatergic synapse publisher: Institute of Science and Technology Austria related_material: record: - id: '18603' relation: used_in_publication status: public status: public title: Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: research_data user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d year: '2024' ... --- OA_place: publisher OA_type: hybrid _id: '18492' abstract: - lang: eng text: 'Surveys in the Milky Way and Large Magellanic Cloud have revealed that the majority of massive stars will interact with companions during their lives. However, knowledge of the binary properties of massive stars at low metallicity, and therefore in conditions approaching those of the Early Universe, remain sparse. We present the Binarity at LOw Metallicity (BLOeM) campaign, an ESO large programme designed to obtain 25 epochs of spectroscopy for 929 massive stars in the Small Magellanic Cloud, allowing us to probe multiplicity in the lowest-metallicity conditions to date (Z = 0.2 Z⊙). BLOeM will provide (i) the binary fraction, (ii) the orbital configurations of systems with periods of P ≲ 3 yr, (iii) dormant black-hole binary candidates (OB+BH), and (iv) a legacy database of physical parameters of massive stars at low metallicity. Main sequence (OB-type) and evolved (OBAF-type) massive stars are observed with the LR02 setup of the GIRAFFE instrument of the Very Large Telescope (3960–4570 Å resolving power R = 6200; typical signal-to-noise ratio(S/N) ≈70–100). This paper utilises the first nine epochs obtained over a three-month time period. We describe the survey and data reduction, perform a spectral classification of the stacked spectra, and construct a Hertzsprung-Russell diagram of the sample via spectral-type and photometric calibrations. Our detailed classification reveals that the sample covers spectral types from O4 to F5, spanning the effective temperature and luminosity ranges 6.5 ≲ Teff/kK ≲ 45 and 3.7 < log L/L⊙ < 6.1 and initial masses of 8 ≲ Mini ≲ 80 M⊙. The sample comprises 159 O-type stars, 331 early B-type (B0–3) dwarfs and giants (luminosity classes V–III), 303 early B-type supergiants (II–I), and 136 late-type BAF supergiants. At least 82 stars are OBe stars: 20 O-type and 62 B-type (13% and 11% of the respective samples). In addition, the sample includes 4 high-mass X-ray binaries, 3 stars resembling luminous blue variables, 2 bloated stripped-star candidates, 2 candidate magnetic stars, and 74 eclipsing binaries.' acknowledgement: 'The research leading to these results has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement numbers 772225: MULTIPLES). PAC and JMB are supported by the Science and Technology Facilities Council research grant ST/V000853/1 (PI. V. Dhillon). DMB gratefully acknowledges support from UK Research and Innovation (UKRI) in the form of a Frontier Research grant under the UK government’s ERC Horizon Europe funding guarantee (SYMPHONY; PI Bowman; grant number: EP/Y031059/1), and a Royal Society University Research Fellowship (PI Bowman; grant number: URF\R1\231631). ZK acknowledges support from JSPS Kakenhi Grant-in-Aid for Scientific Research (23K19071). IM acknowledges support from the Australian Research Council (ARC) Centre of Excellence for Gravitational Wave Discovery (OzGrav), through project number CE230100016. AACS, VR, RRL, and MBP are funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) in the form of an Emmy Noether Research Group – Project-ID 445674056 (SA4064/1-1, PI Sander). GGT and JJ are supported by the German Deutsche Forschungsgemeinschaft (DFG) under Project-ID 496854903 (SA4064/2-1, PI Sander) VR, GGT, and AACS further acknowledge support from the Federal Ministry of Education and Research (BMBF) and the Baden-Württemberg Ministry of Science as part of the Excellence Strategy of the German Federal and State Governments. ECS acknowledges financial support by the Federal Ministry for Economic Affairs and Climate Action (BMWK) via the German Aerospace Center (Deutsches Zentrum für Luft- und Raumfahrt, DLR) grant 50 OR 2306 (PI: Ramachandran/Sander). This work has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 945806) and is supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy EXC 2181/1-390900948 (the Heidelberg STRUCTURES Excellence Cluster). LMO is thankful for the funding provided by the DFG grant 443790621. This paper benefited from discussions at the International Space Science Institute (ISSI) in Bern through ISSI International Team project 512 (Multiwavelength View on Massive Stars in the Era of Multimessenger Astronomy). DP acknowledges financial support by the Deutsches Zentrum für Luft und Raumfahrt (DLR) grant FKZ 50OR2005. JIV acknowledges the European Research Council for support from the ERC Advanced grant ERC-2021-ADG101054731. JSV is supported by STFC (Science and Technology Facilities Council) funding under grant number ST/V000233/1. GH, SS-D, SRB and AH acknowledge support from the State Research Agency (AEI) of the Spanish Ministry of Science and Innovation (MICIN) and the European Regional Development Fund, FEDER under grants PID2021-122397NB-C21 and CEX2019-000920-S. SRB also acknowledges financial support by NextGeneration EU/PRTR and MIU (UNI/551/2021) through grant Margarita Salas-ULL. DFR is thankful for the support of the CAPES-Br and FAPERJ/DSC-10 (SEI-260003/001630/2023). F.N., and L.R.P. acknowledge support by grants PID2019-105552RB-C41 and PID2022-137779OB-C41 funded by MCIN/AEI/10.13039/501100011033 by “ERDF A way of making Europe”. MG acknowledges financial support from the grants PID2021-125485NB-C22, CEX2019-000918-M funded by MCIN/AEI/10.13039/501100011033 (State Agency for Research of the Spanish Ministry of Science and Innovation) and SGR-2021-01069 (AGAUR). GM acknowledges funding support from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 772086). JMA acknowledges support from the Spanish Government Ministerio de Ciencia e Innovación and Agencia Estatal de Investigación (10.13 039/501 100 011 033) through grant PID2022-136640 NB-C22 and from the Consejo Superior de Investigaciones Científicas (CSIC) through grant 2022-AEP 005. MP is supported by the BEKKER fellowship BPN/BEK/2022/1/00106 from the Polish National Agency for Academic Exchange. KS is funded by the National Science Center (NCN), Poland, under grant number OPUS 2021/41/B/ST9/00757. JM acknowledges support from a Royal Society-Science Foundation Ireland University Research Fellowship. SJ acknowledges support from the FWO PhD fellowship under project 11E1721N. FB acknowledges the support of the European Research Council (ERC) Horizon Europe under grant agreement number 101044048.' article_number: A289 article_processing_charge: Yes (in subscription journal) article_type: original arxiv: 1 author: - first_name: T. full_name: Shenar, T. last_name: Shenar - first_name: J. full_name: Bodensteiner, J. last_name: Bodensteiner - first_name: H. full_name: Sana, H. last_name: Sana - first_name: P. A. full_name: Crowther, P. A. last_name: Crowther - first_name: D. J. full_name: Lennon, D. J. last_name: Lennon - first_name: M. full_name: Abdul-Masih, M. last_name: Abdul-Masih - first_name: L. A. full_name: Almeida, L. A. last_name: Almeida - first_name: F. full_name: Backs, F. last_name: Backs - first_name: S. R. full_name: Berlanas, S. R. last_name: Berlanas - first_name: M. full_name: Bernini-Peron, M. last_name: Bernini-Peron - first_name: J. M. full_name: Bestenlehner, J. M. last_name: Bestenlehner - first_name: D. M. full_name: Bowman, D. M. last_name: Bowman - first_name: V. A. full_name: Bronner, V. A. last_name: Bronner - first_name: N. full_name: Britavskiy, N. last_name: Britavskiy - first_name: A. full_name: De Koter, A. last_name: De Koter - first_name: S. E. full_name: De Mink, S. E. last_name: De Mink - first_name: K. full_name: Deshmukh, K. last_name: Deshmukh - first_name: C. J. full_name: Evans, C. J. last_name: Evans - first_name: M. full_name: Fabry, M. last_name: Fabry - first_name: M. full_name: Gieles, M. last_name: Gieles - first_name: A. full_name: Gilkis, A. last_name: Gilkis - first_name: G. full_name: González-Torà, G. last_name: González-Torà - first_name: G. full_name: Gräfener, G. last_name: Gräfener - first_name: Ylva Louise Linsdotter full_name: Götberg, Ylva Louise Linsdotter id: d0648d0c-0f64-11ee-a2e0-dd0faa2e4f7d last_name: Götberg orcid: 0000-0002-6960-6911 - first_name: C. full_name: Hawcroft, C. last_name: Hawcroft - first_name: V. full_name: Hénault-Brunet, V. last_name: Hénault-Brunet - first_name: A. full_name: Herrero, A. last_name: Herrero - first_name: G. full_name: Holgado, G. last_name: Holgado - first_name: S. full_name: Janssens, S. last_name: Janssens - first_name: C. full_name: Johnston, C. last_name: Johnston - first_name: J. full_name: Josiek, J. last_name: Josiek - first_name: S. full_name: Justham, S. last_name: Justham - first_name: V. M. full_name: Kalari, V. M. last_name: Kalari - first_name: Z. Z. full_name: Katabi, Z. Z. last_name: Katabi - first_name: Z. full_name: Keszthelyi, Z. last_name: Keszthelyi - first_name: J. full_name: Klencki, J. last_name: Klencki - first_name: J. full_name: Kubát, J. last_name: Kubát - first_name: B. full_name: Kubátová, B. last_name: Kubátová - first_name: N. full_name: Langer, N. last_name: Langer - first_name: R. R. full_name: Lefever, R. R. last_name: Lefever - first_name: B. full_name: Ludwig, B. last_name: Ludwig - first_name: J. full_name: Mackey, J. last_name: Mackey - first_name: L. full_name: Mahy, L. last_name: Mahy - first_name: J. full_name: Maíz Apellániz, J. last_name: Maíz Apellániz - first_name: I. full_name: Mandel, I. last_name: Mandel - first_name: G. full_name: Maravelias, G. last_name: Maravelias - first_name: P. full_name: Marchant, P. last_name: Marchant - first_name: A. full_name: Menon, A. last_name: Menon - first_name: F. full_name: Najarro, F. last_name: Najarro - first_name: L. M. full_name: Oskinova, L. M. last_name: Oskinova - first_name: A. J.G. full_name: O'Grady, A. J.G. last_name: O'Grady - first_name: R. full_name: Ovadia, R. last_name: Ovadia - first_name: L. R. full_name: Patrick, L. R. last_name: Patrick - first_name: D. full_name: Pauli, D. last_name: Pauli - first_name: M. full_name: Pawlak, M. last_name: Pawlak - first_name: V. full_name: Ramachandran, V. last_name: Ramachandran - first_name: M. full_name: Renzo, M. last_name: Renzo - first_name: D. F. full_name: Rocha, D. F. last_name: Rocha - first_name: A. A.C. full_name: Sander, A. A.C. last_name: Sander - first_name: T. full_name: Sayada, T. last_name: Sayada - first_name: F. R.N. full_name: Schneider, F. R.N. last_name: Schneider - first_name: A. full_name: Schootemeijer, A. last_name: Schootemeijer - first_name: E. C. full_name: Schösser, E. C. last_name: Schösser - first_name: C. full_name: Schürmann, C. last_name: Schürmann - first_name: K. full_name: Sen, K. last_name: Sen - first_name: S. full_name: Shahaf, S. last_name: Shahaf - first_name: S. full_name: Simón-Díaz, S. last_name: Simón-Díaz - first_name: M. full_name: Stoop, M. last_name: Stoop - first_name: S. full_name: Toonen, S. last_name: Toonen - first_name: F. full_name: Tramper, F. last_name: Tramper - first_name: J. Th full_name: Van Loon, J. Th last_name: Van Loon - first_name: R. full_name: Valli, R. last_name: Valli - first_name: L. A.C. full_name: Van Son, L. A.C. last_name: Van Son - first_name: A. full_name: Vigna-Gómez, A. last_name: Vigna-Gómez - first_name: J. I. full_name: Villaseñor, J. I. last_name: Villaseñor - first_name: J. S. full_name: Vink, J. S. last_name: Vink - first_name: C. full_name: Wang, C. last_name: Wang - first_name: R. full_name: Willcox, R. last_name: Willcox citation: ama: 'Shenar T, Bodensteiner J, Sana H, et al. Binarity at LOw Metallicity (BLOeM): A spectroscopic VLT monitoring survey of massive stars in the SMC. Astronomy & Astrophysics. 2024;690. doi:10.1051/0004-6361/202451586' apa: 'Shenar, T., Bodensteiner, J., Sana, H., Crowther, P. A., Lennon, D. J., Abdul-Masih, M., … Willcox, R. (2024). Binarity at LOw Metallicity (BLOeM): A spectroscopic VLT monitoring survey of massive stars in the SMC. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202451586' chicago: 'Shenar, T., J. Bodensteiner, H. Sana, P. A. Crowther, D. J. Lennon, M. Abdul-Masih, L. A. Almeida, et al. “Binarity at LOw Metallicity (BLOeM): A Spectroscopic VLT Monitoring Survey of Massive Stars in the SMC.” Astronomy & Astrophysics. EDP Sciences, 2024. https://doi.org/10.1051/0004-6361/202451586.' ieee: 'T. Shenar et al., “Binarity at LOw Metallicity (BLOeM): A spectroscopic VLT monitoring survey of massive stars in the SMC,” Astronomy & Astrophysics, vol. 690. EDP Sciences, 2024.' ista: 'Shenar T, Bodensteiner J, Sana H, Crowther PA, Lennon DJ, Abdul-Masih M, Almeida LA, Backs F, Berlanas SR, Bernini-Peron M, Bestenlehner JM, Bowman DM, Bronner VA, Britavskiy N, De Koter A, De Mink SE, Deshmukh K, Evans CJ, Fabry M, Gieles M, Gilkis A, González-Torà G, Gräfener G, Götberg YLL, Hawcroft C, Hénault-Brunet V, Herrero A, Holgado G, Janssens S, Johnston C, Josiek J, Justham S, Kalari VM, Katabi ZZ, Keszthelyi Z, Klencki J, Kubát J, Kubátová B, Langer N, Lefever RR, Ludwig B, Mackey J, Mahy L, Maíz Apellániz J, Mandel I, Maravelias G, Marchant P, Menon A, Najarro F, Oskinova LM, O’Grady AJG, Ovadia R, Patrick LR, Pauli D, Pawlak M, Ramachandran V, Renzo M, Rocha DF, Sander AAC, Sayada T, Schneider FRN, Schootemeijer A, Schösser EC, Schürmann C, Sen K, Shahaf S, Simón-Díaz S, Stoop M, Toonen S, Tramper F, Van Loon JT, Valli R, Van Son LAC, Vigna-Gómez A, Villaseñor JI, Vink JS, Wang C, Willcox R. 2024. Binarity at LOw Metallicity (BLOeM): A spectroscopic VLT monitoring survey of massive stars in the SMC. Astronomy & Astrophysics. 690, A289.' mla: 'Shenar, T., et al. “Binarity at LOw Metallicity (BLOeM): A Spectroscopic VLT Monitoring Survey of Massive Stars in the SMC.” Astronomy & Astrophysics, vol. 690, A289, EDP Sciences, 2024, doi:10.1051/0004-6361/202451586.' short: T. Shenar, J. Bodensteiner, H. Sana, P.A. Crowther, D.J. Lennon, M. Abdul-Masih, L.A. Almeida, F. Backs, S.R. Berlanas, M. Bernini-Peron, J.M. Bestenlehner, D.M. Bowman, V.A. Bronner, N. Britavskiy, A. De Koter, S.E. De Mink, K. Deshmukh, C.J. Evans, M. Fabry, M. Gieles, A. Gilkis, G. González-Torà, G. Gräfener, Y.L.L. Götberg, C. Hawcroft, V. Hénault-Brunet, A. Herrero, G. Holgado, S. Janssens, C. Johnston, J. Josiek, S. Justham, V.M. Kalari, Z.Z. Katabi, Z. Keszthelyi, J. Klencki, J. Kubát, B. Kubátová, N. Langer, R.R. Lefever, B. Ludwig, J. Mackey, L. Mahy, J. Maíz Apellániz, I. Mandel, G. Maravelias, P. Marchant, A. Menon, F. Najarro, L.M. Oskinova, A.J.G. O’Grady, R. Ovadia, L.R. Patrick, D. Pauli, M. Pawlak, V. Ramachandran, M. Renzo, D.F. Rocha, A.A.C. Sander, T. Sayada, F.R.N. Schneider, A. Schootemeijer, E.C. Schösser, C. Schürmann, K. Sen, S. Shahaf, S. Simón-Díaz, M. Stoop, S. Toonen, F. Tramper, J.T. Van Loon, R. Valli, L.A.C. Van Son, A. Vigna-Gómez, J.I. Villaseñor, J.S. Vink, C. Wang, R. Willcox, Astronomy & Astrophysics 690 (2024). das_tickbox: '1' date_created: 2024-11-03T23:01:44Z date_published: 2024-10-01T00:00:00Z date_updated: 2026-09-16T10:50:17Z day: '01' ddc: - '520' department: - _id: YlGo doi: 10.1051/0004-6361/202451586 external_id: arxiv: - '2407.14593' isi: - '001336770600014' file: - access_level: open_access checksum: b378b36726591f3479a927d924ab8e77 content_type: application/pdf creator: dernst date_created: 2024-11-04T09:52:26Z date_updated: 2024-11-04T09:52:26Z file_id: '18500' file_name: 2024_AstronomyAstrophysics_Shenar.pdf file_size: 4267349 relation: main_file success: 1 file_date_updated: 2024-11-04T09:52:26Z fulldoi: https://doi.org/10.1051/0004-6361/202451586 has_accepted_license: '1' intvolume: ' 690' isi: 1 language: - iso: eng month: '10' oa: 1 oa_version: Published Version publication: Astronomy & Astrophysics publication_identifier: eissn: - 1432-0746 issn: - 0004-6361 publication_status: published publisher: EDP Sciences quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: no title: 'Binarity at LOw Metallicity (BLOeM): A spectroscopic VLT monitoring survey of massive stars in the SMC' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 690 year: '2024' ... --- APC_amount: 2933,65 EUR DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '14980' abstract: - lang: eng text: Precision sensing and manipulation of milligram-scale mechanical oscillators has attracted growing interest in the fields of table-top explorations of gravity and tests of quantum mechanics at macroscopic scales. Torsional oscillators present an opportunity in this regard due to their remarked isolation from environmental noise. For torsional motion, an effective employment of optical cavities to enhance optomechanical interactions—as already established for linear oscillators—so far faced certain challenges. Here, we propose a concept for sensing and manipulating torsional motion, where exclusively the torsional rotations of a pendulum are mapped onto the path length of a single two-mirror optical cavity. The concept inherently alleviates many limitations of previous approaches. A proof-of-principle experiment is conducted with a rigidly controlled pendulum to explore the sensing aspects of the concept and to identify practical limitations in a potential state-of-the art setup. Based on this study, we anticipate development of precision torque sensors utilizing torsional pendulums that can support sensitivities below 10−19Nm/√Hz, while the motion of the pendulums are dominated by quantum radiation pressure noise at sub-microwatts of incoming laser power. These developments will provide horizons for experiments at the interface of quantum mechanics and gravity. acknowledgement: "We thank Pere Rosselló for his contributions to the initial modeling of the presented sensing technique. This work was supported by Institute of Science and Technology Austria, and\r\nthe European Research Council under Grant No. 101087907 (ERC CoG QuHAMP)." article_number: '013141' article_processing_charge: Yes article_type: original arxiv: 1 author: - first_name: Sofya full_name: Agafonova, Sofya id: 09501ff6-dca7-11ea-a8ae-b3e0b9166e80 last_name: Agafonova orcid: 0000-0003-0582-2946 - first_name: Umang full_name: Mishra, Umang id: 4328fa4c-f128-11eb-9611-c107b0fe4d51 last_name: Mishra - first_name: Fritz R full_name: Diorico, Fritz R id: 2E054C4C-F248-11E8-B48F-1D18A9856A87 last_name: Diorico orcid: 0000-0002-4947-8924 - first_name: Onur full_name: Hosten, Onur id: 4C02D85E-F248-11E8-B48F-1D18A9856A87 last_name: Hosten orcid: 0000-0002-2031-204X citation: ama: Agafonova S, Mishra U, Diorico FR, Hosten O. Zigzag optical cavity for sensing and controlling torsional motion. Physical Review Research. 2024;6(1). doi:10.1103/physrevresearch.6.013141 apa: Agafonova, S., Mishra, U., Diorico, F. R., & Hosten, O. (2024). Zigzag optical cavity for sensing and controlling torsional motion. Physical Review Research. American Physical Society. https://doi.org/10.1103/physrevresearch.6.013141 chicago: Agafonova, Sofia, Umang Mishra, Fritz R Diorico, and Onur Hosten. “Zigzag Optical Cavity for Sensing and Controlling Torsional Motion.” Physical Review Research. American Physical Society, 2024. https://doi.org/10.1103/physrevresearch.6.013141. ieee: S. Agafonova, U. Mishra, F. R. Diorico, and O. Hosten, “Zigzag optical cavity for sensing and controlling torsional motion,” Physical Review Research, vol. 6, no. 1. American Physical Society, 2024. ista: Agafonova S, Mishra U, Diorico FR, Hosten O. 2024. Zigzag optical cavity for sensing and controlling torsional motion. Physical Review Research. 6(1), 013141. mla: Agafonova, Sofia, et al. “Zigzag Optical Cavity for Sensing and Controlling Torsional Motion.” Physical Review Research, vol. 6, no. 1, 013141, American Physical Society, 2024, doi:10.1103/physrevresearch.6.013141. short: S. Agafonova, U. Mishra, F.R. Diorico, O. Hosten, Physical Review Research 6 (2024). corr_author: '1' das_tickbox: '0' date_created: 2024-02-12T11:42:18Z date_published: 2024-02-05T00:00:00Z date_updated: 2026-09-17T09:13:08Z day: '05' ddc: - '530' department: - _id: OnHo doi: 10.1103/physrevresearch.6.013141 external_id: arxiv: - '2306.12804' file: - access_level: open_access checksum: 3a39ebffb24c1cc1dd0b547a726dc52d content_type: application/pdf creator: dernst date_created: 2024-02-12T11:46:50Z date_updated: 2024-02-12T11:46:50Z file_id: '14981' file_name: 2024_PhysicalRevResearch_Agafonova.pdf file_size: 1437167 relation: main_file success: 1 file_date_updated: 2024-02-12T11:46:50Z fulldoi: https://doi.org/10.1103/physrevresearch.6.013141 has_accepted_license: '1' intvolume: ' 6' issue: '1' language: - iso: eng month: '02' oa: 1 oa_version: Published Version project: - _id: bdb2a702-d553-11ed-ba76-f12e3e5a3bc6 grant_number: '101087907' name: 'A quantum hybrid of atoms and milligram-scale pendulums: towards gravitational quantum mechanics' publication: Physical Review Research publication_identifier: eissn: - 2643-1564 publication_status: published publisher: American Physical Society quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: no title: Zigzag optical cavity for sensing and controlling torsional motion tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 6 year: '2024' ... --- OA_place: publisher OA_type: hybrid _id: '18910' abstract: - lang: eng text: Proteins often undergo large-scale conformational transitions, in which secondary and tertiary structure elements (loops, helices, and domains) change their structures or their positions with respect to each other. Simple considerations suggest that such dynamics should be relatively fast, but the functional cycles of many proteins are often relatively slow. Sophisticated experimental methods are starting to tackle this dichotomy and shed light on the contribution of large-scale conformational dynamics to protein function. In this review, we focus on the contribution of single-molecule Förster resonance energy transfer and nuclear magnetic resonance (NMR) spectroscopies to the study of conformational dynamics. We briefly describe the state of the art in each of these techniques and then point out their similarities and differences, as well as the relative strengths and weaknesses of each. Several case studies, in which the connection between fast conformational dynamics and slower function has been demonstrated, are then introduced and discussed. These examples include both enzymes and large protein machines, some of which have been studied by both NMR and fluorescence spectroscopies. acknowledgement: G.H. is the incumbent of the Hilda Pomeraniec Memorial Professorial Chair. He has been partially funded by the European Research Council under the European Union's Horizon 2020 research and innovation program (grant 742637, SMALLOSTERY), by National Science Foundation–US-Israel Binational Science Foundation grant 2021700, and by an Israel Science Foundation Breakthrough grant (1924/22). P.S. acknowledges funding from the Austrian Science Fund (project “AlloSpace,” I05812) and intramural funding from the Institute of Science and Technology Austria. article_processing_charge: No article_type: original author: - first_name: Paul full_name: Schanda, Paul id: 7B541462-FAF6-11E9-A490-E8DFE5697425 last_name: Schanda orcid: 0000-0002-9350-7606 - first_name: Gilad full_name: Haran, Gilad last_name: Haran citation: ama: Schanda P, Haran G. NMR and single-molecule FRET insights into fast protein motions and their relation to function. Annual Review of Biophysics. 2024;53:247-273. doi:10.1146/annurev-biophys-070323-022428 apa: Schanda, P., & Haran, G. (2024). NMR and single-molecule FRET insights into fast protein motions and their relation to function. Annual Review of Biophysics. Annual Reviews. https://doi.org/10.1146/annurev-biophys-070323-022428 chicago: Schanda, Paul, and Gilad Haran. “NMR and Single-Molecule FRET Insights into Fast Protein Motions and Their Relation to Function.” Annual Review of Biophysics. Annual Reviews, 2024. https://doi.org/10.1146/annurev-biophys-070323-022428. ieee: P. Schanda and G. Haran, “NMR and single-molecule FRET insights into fast protein motions and their relation to function,” Annual Review of Biophysics, vol. 53. Annual Reviews, pp. 247–273, 2024. ista: Schanda P, Haran G. 2024. NMR and single-molecule FRET insights into fast protein motions and their relation to function. Annual Review of Biophysics. 53, 247–273. mla: Schanda, Paul, and Gilad Haran. “NMR and Single-Molecule FRET Insights into Fast Protein Motions and Their Relation to Function.” Annual Review of Biophysics, vol. 53, Annual Reviews, 2024, pp. 247–73, doi:10.1146/annurev-biophys-070323-022428. short: P. Schanda, G. Haran, Annual Review of Biophysics 53 (2024) 247–273. corr_author: '1' das_tickbox: '0' date_created: 2025-01-27T13:40:34Z date_published: 2024-07-01T00:00:00Z date_updated: 2026-09-17T09:44:33Z day: '01' ddc: - '570' department: - _id: PaSc doi: 10.1146/annurev-biophys-070323-022428 external_id: isi: - '001278237500012' pmid: - '38346243' file: - access_level: open_access checksum: c90861542ae3f9147939030d5bafed3c content_type: application/pdf creator: dernst date_created: 2025-01-27T13:44:59Z date_updated: 2025-01-27T13:44:59Z file_id: '18911' file_name: 2024_AnnualReviews_Schanda.pdf file_size: 3025589 relation: main_file success: 1 file_date_updated: 2025-01-27T13:44:59Z fulldoi: https://doi.org/10.1146/annurev-biophys-070323-022428 has_accepted_license: '1' intvolume: ' 53' isi: 1 language: - iso: eng month: '07' oa: 1 oa_version: Published Version page: 247-273 pmid: 1 project: - _id: eb9c82eb-77a9-11ec-83b8-aadd536561cf grant_number: I05812 name: AlloSpace. The emergence and mechanisms of allostery publication: Annual Review of Biophysics publication_identifier: eissn: - 1936-1238 issn: - 1936-122X publication_status: published publisher: Annual Reviews quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: no title: NMR and single-molecule FRET insights into fast protein motions and their relation to function tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 53 year: '2024' ... --- _id: '15117' abstract: - lang: eng text: 'The hippocampal mossy fiber synapse, formed between axons of dentate gyrus granule cells and dendrites of CA3 pyramidal neurons, is a key synapse in the trisynaptic circuitry of the hippocampus. Because of its comparatively large size, this synapse is accessible to direct presynaptic recording, allowing a rigorous investigation of the biophysical mechanisms of synaptic transmission and plasticity. Furthermore, because of its placement in the very center of the hippocampal memory circuit, this synapse seems to be critically involved in several higher network functions, such as learning, memory, pattern separation, and pattern completion. Recent work based on new technologies in both nanoanatomy and nanophysiology, including presynaptic patch-clamp recording, paired recording, super-resolution light microscopy, and freeze-fracture and “flash-and-freeze” electron microscopy, has provided new insights into the structure, biophysics, and network function of this intriguing synapse. This brings us one step closer to answering a fundamental question in neuroscience: how basic synaptic properties shape higher network computations.' acknowledgement: "We thank previous students, postdocs, and collaborators, particularly J. Geiger, and (in alphabetical order) H. Alle, J. Bischofberger, C. Borges-Merjane, D. Engel, M. Frotscher, S. Hallermann, M. Heckmann, S. Jamrichova, O. Kim, L. Li, K. Lichter, P. Lin, J. Lübke, Y. Okamoto, C. Pawlu, C. Schmidt-Hieber, N. Spruston, and N. Vyleta for their outstanding experimental contributions. We also thank P. Castillo, J. Geiger, T. Sakaba, S. Siegert, T. Vogels, and J. Watson for critically reading the manuscript, E. Kralli-Beller for text editing, and J. Malikovic and L. Slomianka for useful discussions. We apologize that, due to space constraints, not all relevant papers could be cited.\r\nThis project was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement 692692, AdG “GIANTSYN”) and the Fonds zur Förderung der Wissenschaftlichen Forschung (Z 312-B27, Wittgenstein Award; P 36232-B, stand-alone grant), both to P.J." article_processing_charge: No article_type: review author: - first_name: David H full_name: Vandael, David H id: 3AE48E0A-F248-11E8-B48F-1D18A9856A87 last_name: Vandael orcid: 0000-0001-7577-1676 - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 citation: ama: Vandael DH, Jonas PM. Structure, biophysics, and circuit function of a “giant” cortical presynaptic terminal. Science. 2024;383(6687):eadg6757. doi:10.1126/science.adg6757 apa: Vandael, D. H., & Jonas, P. M. (2024). Structure, biophysics, and circuit function of a “giant” cortical presynaptic terminal. Science. AAAS. https://doi.org/10.1126/science.adg6757 chicago: Vandael, David H, and Peter M Jonas. “Structure, Biophysics, and Circuit Function of a ‘Giant’ Cortical Presynaptic Terminal.” Science. AAAS, 2024. https://doi.org/10.1126/science.adg6757. ieee: D. H. Vandael and P. M. Jonas, “Structure, biophysics, and circuit function of a ‘giant’ cortical presynaptic terminal,” Science, vol. 383, no. 6687. AAAS, p. eadg6757, 2024. ista: Vandael DH, Jonas PM. 2024. Structure, biophysics, and circuit function of a ‘giant’ cortical presynaptic terminal. Science. 383(6687), eadg6757. mla: Vandael, David H., and Peter M. Jonas. “Structure, Biophysics, and Circuit Function of a ‘Giant’ Cortical Presynaptic Terminal.” Science, vol. 383, no. 6687, AAAS, 2024, p. eadg6757, doi:10.1126/science.adg6757. short: D.H. Vandael, P.M. Jonas, Science 383 (2024) eadg6757. corr_author: '1' das_tickbox: '0' date_created: 2024-03-17T23:00:57Z date_published: 2024-03-08T00:00:00Z date_updated: 2026-09-17T09:49:03Z day: '08' department: - _id: PeJo doi: 10.1126/science.adg6757 ec_funded: 1 external_id: isi: - '001216996700015' pmid: - '38452088' fulldoi: https://doi.org/10.1126/science.adg6757 intvolume: ' 383' isi: 1 issue: '6687' language: - iso: eng month: '03' oa_version: None page: eadg6757 pmid: 1 project: - _id: 25B7EB9E-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '692692' name: Biophysics and circuit function of a giant cortical glutamatergic synapse - _id: 25C5A090-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: Z00312 name: Synaptic communication in neuronal microcircuits - _id: bd88be38-d553-11ed-ba76-81d5a70a6ef5 grant_number: P36232 name: Mechanisms of GABA release in hippocampal circuits publication: Science publication_identifier: eissn: - 1095-9203 publication_status: published publisher: AAAS quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: no title: Structure, biophysics, and circuit function of a "giant" cortical presynaptic terminal type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 383 year: '2024' ... --- _id: '18058' abstract: - lang: eng text: DNA cloning is a core technique in biomedical and biotechnological research and is used to assemble and modify DNA fragments at will. While DNA cloning has traditionally relied on restriction enzymes, recent homology-based methods offer improved protocols together with seamless and directional assembly of desired products, overcoming the main disadvantages of restriction enzyme DNA cloning. This chapter provides a historical perspective on DNA cloning, presents a detailed discussion on state-of-the-art in vitro and in vivo homology-based methodologies, covering the basics of how to perform all major plasmid modifications (sub-cloning, site-directed mutagenesis, insertions, and deletions), and gives examples of how to apply these techniques for complex DNA cloning projects. article_processing_charge: No author: - first_name: Jake full_name: Watson, Jake id: 63836096-4690-11EA-BD4E-32803DDC885E last_name: Watson orcid: 0000-0002-8698-3823 - first_name: Sandra full_name: Arroyo-Urea, Sandra last_name: Arroyo-Urea - first_name: Javier full_name: García-Nafría, Javier last_name: García-Nafría citation: ama: 'Watson J, Arroyo-Urea S, García-Nafría J. DNA Cloning. In: Liu D, ed. Handbook of Molecular Biotechnology. 1st ed. Boca Raton: CRC Press; 2024:66-72. doi:10.1201/9781003055211-8' apa: 'Watson, J., Arroyo-Urea, S., & García-Nafría, J. (2024). DNA Cloning. In D. Liu (Ed.), Handbook of Molecular Biotechnology (1st ed., pp. 66–72). Boca Raton: CRC Press. https://doi.org/10.1201/9781003055211-8' chicago: 'Watson, Jake, Sandra Arroyo-Urea, and Javier García-Nafría. “DNA Cloning.” In Handbook of Molecular Biotechnology, edited by Dongyou Liu, 1st ed., 66–72. Boca Raton: CRC Press, 2024. https://doi.org/10.1201/9781003055211-8.' ieee: 'J. Watson, S. Arroyo-Urea, and J. García-Nafría, “DNA Cloning,” in Handbook of Molecular Biotechnology, 1st ed., D. Liu, Ed. Boca Raton: CRC Press, 2024, pp. 66–72.' ista: 'Watson J, Arroyo-Urea S, García-Nafría J. 2024.DNA Cloning. In: Handbook of Molecular Biotechnology. , 66–72.' mla: Watson, Jake, et al. “DNA Cloning.” Handbook of Molecular Biotechnology, edited by Dongyou Liu, 1st ed., CRC Press, 2024, pp. 66–72, doi:10.1201/9781003055211-8. short: J. Watson, S. Arroyo-Urea, J. García-Nafría, in:, D. Liu (Ed.), Handbook of Molecular Biotechnology, 1st ed., CRC Press, Boca Raton, 2024, pp. 66–72. das_tickbox: '0' date_created: 2024-09-11T10:40:36Z date_published: 2024-09-05T00:00:00Z date_updated: 2026-09-17T09:58:21Z day: '05' department: - _id: PeJo doi: 10.1201/9781003055211-8 edition: '1' editor: - first_name: Dongyou full_name: Liu, Dongyou last_name: Liu fulldoi: https://doi.org/10.1201/9781003055211-8 language: - iso: eng month: '09' oa_version: None page: 66-72 place: Boca Raton publication: Handbook of Molecular Biotechnology publication_identifier: eisbn: - '9781003055211' publication_status: published publisher: CRC Press quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: no title: DNA Cloning type: book_chapter user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 year: '2024' ... --- OA_place: publisher OA_type: hybrid _id: '18587' abstract: - lang: eng text: Many scientific breakthroughs have depended on animal research, yet the ethical concerns surrounding the use of animals in experimentation have long prompted discussions about humane treatment and responsible scientific practice. First articulated by Russell and Burch, the 3Rs Principles of Replacement, Reduction, and Refinement have gained widespread recognition as basic guidelines for animal research. Over time, the 3Rs have transcended the research community, influencing policy decisions, animal welfare advocacy and public perception of animal experimentation. Despite their broad acceptance, interpretations of the 3Rs vary substantially, shaping statutory frameworks at various levels, with both technical and practical impacts. acknowledgement: This publication is based upon work from the Ethics Crossover Group within the COST Action IMPROVE (“3Rs concepts to improve the quality of biomedical science”), CA21139, supported by COST (European Cooperation in Science and Technology). We acknowledge the input and advice from Dr. Susanna Louhimies. article_processing_charge: No article_type: letter_note author: - first_name: Jan full_name: Lauwereyns, Jan last_name: Lauwereyns - first_name: Jeffrey full_name: Bajramovic, Jeffrey last_name: Bajramovic - first_name: Bettina full_name: Bert, Bettina last_name: Bert - first_name: Samuel full_name: Camenzind, Samuel last_name: Camenzind - first_name: Joery full_name: De Kock, Joery last_name: De Kock - first_name: Alisa full_name: Elezović, Alisa last_name: Elezović - first_name: Sevilay full_name: Erden, Sevilay last_name: Erden - first_name: Fernando full_name: Gonzalez-Uarquin, Fernando last_name: Gonzalez-Uarquin - first_name: Yesim Isil full_name: Ulman, Yesim Isil last_name: Ulman - first_name: Orsolya Ivett full_name: Hoffmann, Orsolya Ivett last_name: Hoffmann - first_name: Maria full_name: Kitsara, Maria last_name: Kitsara - first_name: Nikolaos full_name: Kostomitsopoulos, Nikolaos last_name: Kostomitsopoulos - first_name: Winfried full_name: Neuhaus, Winfried last_name: Neuhaus - first_name: Benoit full_name: Petit-Demouliere, Benoit last_name: Petit-Demouliere - first_name: Simone full_name: Pollo, Simone last_name: Pollo - first_name: Brígida full_name: Riso, Brígida last_name: Riso - first_name: Sophie full_name: Schober, Sophie id: 80b0a0ef-4b9f-11ec-b119-8d9d94c4a1d8 last_name: Schober - first_name: Athanassia full_name: Sotiropoulos, Athanassia last_name: Sotiropoulos - first_name: Aurélie full_name: Thomas, Aurélie last_name: Thomas - first_name: Augusto full_name: Vitale, Augusto last_name: Vitale - first_name: Doris full_name: Wilflingseder, Doris last_name: Wilflingseder - first_name: Arti full_name: Ahluwalia, Arti last_name: Ahluwalia citation: ama: Lauwereyns J, Bajramovic J, Bert B, et al. Toward a common interpretation of the 3Rs principles in animal research. Lab Animal. 2024;53:347-350. doi:10.1038/s41684-024-01476-2 apa: Lauwereyns, J., Bajramovic, J., Bert, B., Camenzind, S., De Kock, J., Elezović, A., … Ahluwalia, A. (2024). Toward a common interpretation of the 3Rs principles in animal research. Lab Animal. Springer Nature. https://doi.org/10.1038/s41684-024-01476-2 chicago: Lauwereyns, Jan, Jeffrey Bajramovic, Bettina Bert, Samuel Camenzind, Joery De Kock, Alisa Elezović, Sevilay Erden, et al. “Toward a Common Interpretation of the 3Rs Principles in Animal Research.” Lab Animal. Springer Nature, 2024. https://doi.org/10.1038/s41684-024-01476-2. ieee: J. Lauwereyns et al., “Toward a common interpretation of the 3Rs principles in animal research,” Lab Animal, vol. 53. Springer Nature, pp. 347–350, 2024. ista: Lauwereyns J, Bajramovic J, Bert B, Camenzind S, De Kock J, Elezović A, Erden S, Gonzalez-Uarquin F, Ulman YI, Hoffmann OI, Kitsara M, Kostomitsopoulos N, Neuhaus W, Petit-Demouliere B, Pollo S, Riso B, Schober S, Sotiropoulos A, Thomas A, Vitale A, Wilflingseder D, Ahluwalia A. 2024. Toward a common interpretation of the 3Rs principles in animal research. Lab Animal. 53, 347–350. mla: Lauwereyns, Jan, et al. “Toward a Common Interpretation of the 3Rs Principles in Animal Research.” Lab Animal, vol. 53, Springer Nature, 2024, pp. 347–50, doi:10.1038/s41684-024-01476-2. short: J. Lauwereyns, J. Bajramovic, B. Bert, S. Camenzind, J. De Kock, A. Elezović, S. Erden, F. Gonzalez-Uarquin, Y.I. Ulman, O.I. Hoffmann, M. Kitsara, N. Kostomitsopoulos, W. Neuhaus, B. Petit-Demouliere, S. Pollo, B. Riso, S. Schober, A. Sotiropoulos, A. Thomas, A. Vitale, D. Wilflingseder, A. Ahluwalia, Lab Animal 53 (2024) 347–350. das_tickbox: '0' date_created: 2024-11-24T23:01:49Z date_published: 2024-12-01T00:00:00Z date_updated: 2026-09-17T10:29:32Z day: '01' ddc: - '570' department: - _id: PreCl doi: 10.1038/s41684-024-01476-2 external_id: isi: - '001355264100001' pmid: - '39548348' file: - access_level: open_access checksum: 67fc140f761581a291591f075e49b88d content_type: application/pdf creator: dernst date_created: 2024-12-03T14:07:04Z date_updated: 2024-12-03T14:07:04Z file_id: '18614' file_name: 2024_LabAnimal_Lauwereyns.pdf file_size: 967252 relation: main_file success: 1 file_date_updated: 2024-12-03T14:07:04Z fulldoi: https://doi.org/10.1038/s41684-024-01476-2 has_accepted_license: '1' intvolume: ' 53' isi: 1 language: - iso: eng month: '12' oa: 1 oa_version: Published Version page: 347-350 pmid: 1 publication: Lab Animal publication_identifier: eissn: - 1548-4475 issn: - 0093-7355 publication_status: published publisher: Springer Nature quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: no title: Toward a common interpretation of the 3Rs principles in animal research tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 53 year: '2024' ... --- DOAJ_listed: '1' _id: '17409' abstract: - lang: eng text: Light-driven rotary molecular motors are among the most promising classes of responsive molecular machines and take advantage of their intrinsic chirality which governs unidirectional rotation. As a consequence of their dynamic function, they receive considerable interest in the areas of supramolecular chemistry, asymmetric catalysis and responsive materials. Among the emerging classes of responsive photochromic molecules, multistate first-generation molecular motors driven by benign visible light remain unexplored, which limits the exploitation of the full potential of these mechanical light-powered systems. Herein, we describe a series of all-visible-light-driven first-generation molecular motors based on the salicylidene Schiff base functionality. Remarkable redshifts up to 100 nm in absorption are achieved compared to conventional first-generation motor structures. Taking advantage of all-visible-light-driven multistate motor scaffolds, adaptive behaviour is found as well, and potential application in multistate photoluminescence is demonstrated. These functional visible-light-responsive motors will likely stimulate the design and synthesis of more sophisticated nanomachinery with a myriad of future applications in powering dynamic systems. acknowledgement: Financial support from the Netherlands Organization for Scientific Research (NWO-CW), the Dutch Ministry of Education, Culture and Science (Gravitation program No.024.001.035), the China Scholarship Council (CSC PhD Fellowship No.201808330459 to J. S.). We thank Dr. Youxin Fu, Dr. Alexander Ryabchun, Dr. Wojciech Danowski, Dr. Jianyu Zhang and Yahan Shan from University of Groningen for their help to this project and fruitful discussions. article_number: '6461' article_processing_charge: Yes article_type: original author: - first_name: Sven full_name: Van Vliet, Sven last_name: Van Vliet - first_name: Jinyu full_name: Sheng, Jinyu id: 639f0526-27c9-11ee-95a6-966cd7f102d8 last_name: Sheng - first_name: Charlotte N. full_name: Stindt, Charlotte N. last_name: Stindt - first_name: Ben L. full_name: Feringa, Ben L. last_name: Feringa citation: ama: Van Vliet S, Sheng J, Stindt CN, Feringa BL. All-visible-light-driven salicylidene schiff-base-functionalized artificial molecular motors. Nature Communications. 2024;15. doi:10.1038/s41467-024-50587-4 apa: Van Vliet, S., Sheng, J., Stindt, C. N., & Feringa, B. L. (2024). All-visible-light-driven salicylidene schiff-base-functionalized artificial molecular motors. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-024-50587-4 chicago: Van Vliet, Sven, Jinyu Sheng, Charlotte N. Stindt, and Ben L. Feringa. “All-Visible-Light-Driven Salicylidene Schiff-Base-Functionalized Artificial Molecular Motors.” Nature Communications. Springer Nature, 2024. https://doi.org/10.1038/s41467-024-50587-4. ieee: S. Van Vliet, J. Sheng, C. N. Stindt, and B. L. Feringa, “All-visible-light-driven salicylidene schiff-base-functionalized artificial molecular motors,” Nature Communications, vol. 15. Springer Nature, 2024. ista: Van Vliet S, Sheng J, Stindt CN, Feringa BL. 2024. All-visible-light-driven salicylidene schiff-base-functionalized artificial molecular motors. Nature Communications. 15, 6461. mla: Van Vliet, Sven, et al. “All-Visible-Light-Driven Salicylidene Schiff-Base-Functionalized Artificial Molecular Motors.” Nature Communications, vol. 15, 6461, Springer Nature, 2024, doi:10.1038/s41467-024-50587-4. short: S. Van Vliet, J. Sheng, C.N. Stindt, B.L. Feringa, Nature Communications 15 (2024). das_tickbox: '1' dataavailabilitystatement: Data that support the findings of this study are available within the Supplementary Information. All data are available from the corresponding author upon request. The XYZ coordinates of the DFT-optimized structures are available as source data. Source data are provided with this paper. date_created: 2024-08-11T22:01:11Z date_published: 2024-07-31T00:00:00Z date_updated: 2026-09-17T10:46:04Z day: '31' ddc: - '540' department: - _id: RaKl doi: 10.1038/s41467-024-50587-4 external_id: isi: - '001282384300020' pmid: - '39085193' file: - access_level: open_access checksum: 4aca2ea30fe529947cb2f4c7fc2af2df content_type: application/pdf creator: dernst date_created: 2024-08-12T08:23:10Z date_updated: 2024-08-12T08:23:10Z file_id: '17418' file_name: 2024_NatureComm_vanVliet.pdf file_size: 1355696 relation: main_file success: 1 file_date_updated: 2024-08-12T08:23:10Z fulldoi: https://doi.org/10.1038/s41467-024-50587-4 has_accepted_license: '1' intvolume: ' 15' isi: 1 language: - iso: eng month: '07' oa: 1 oa_version: Published Version pmid: 1 publication: Nature Communications publication_identifier: eissn: - 2041-1723 publication_status: published publisher: Springer Nature quality_controlled: '1' researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: yes title: All-visible-light-driven salicylidene schiff-base-functionalized artificial molecular motors tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 15 year: '2024' ... --- _id: '17105' abstract: - lang: eng text: The development of photoresponsive systems with non-invasive orthogonal control by distinct wavelengths of light is still in its infancy. In particular, the design of photochemically triggered-orthogonal systems integrated into solid materials that enable multiple dynamic control over their properties remains a longstanding challenge. Here, we report the orthogonal and reversible control of two types of photoswitches in an integrated solid porous framework, that is, visible-light responsive o-fluoroazobenzene and nitro-spiropyran motifs. The properties of the constructed material can be selectively controlled by different wavelengths of light thus generating four distinct states providing a basis for dynamic multifunctional materials. Solid-state NMR spectroscopy demonstrated the selective transformation of the azobenzene switch in the bulk, which in turn modulates N2 and CO2 adsorption. acknowledgement: 'This work was supported from the following sources: China Scholarship Council (CSC PhD Fellowship No. 201808330459 to J.S.), the Ministry of Education, Culture and Science of the Netherlands (Gravitation Program No. 024.001.035 to BLF), Financial support from The Netherlands Organization for Scientific Research (NWO-CW), the European Research Council (ERC; advanced Grant No. 694345 to B.L.F.). PRIN (SHERPA 2020 No. H45F21003430001) and PRIN (HySTAR 2022 No. H53D23004720006) and Lombardy Region for “Enhancing Photosynthesis” grant (2021-2023 No. H45F21002830007). W.D. is grateful for financial support from Marie Skłodowska-Curie Actions (Individual Fellowship No. 101027639). P.C. is grateful for the financial support provided by the PRELUDIUM grant from the National Science Center Poland (Reg. No: 2023/49/N/ST5/01864).' article_number: e202404878 article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Jinyu full_name: Sheng, Jinyu id: 639f0526-27c9-11ee-95a6-966cd7f102d8 last_name: Sheng - first_name: Jacopo full_name: Perego, Jacopo last_name: Perego - first_name: Silvia full_name: Bracco, Silvia last_name: Bracco - first_name: Piotr full_name: Cieciórski, Piotr last_name: Cieciórski - first_name: Wojciech full_name: Danowski, Wojciech last_name: Danowski - first_name: Angiolina full_name: Comotti, Angiolina last_name: Comotti - first_name: Ben L. full_name: Feringa, Ben L. last_name: Feringa citation: ama: Sheng J, Perego J, Bracco S, et al. Orthogonal photoswitching in a porous organic framework. Angewandte Chemie International Edition. 2024;63(23). doi:10.1002/anie.202404878 apa: Sheng, J., Perego, J., Bracco, S., Cieciórski, P., Danowski, W., Comotti, A., & Feringa, B. L. (2024). Orthogonal photoswitching in a porous organic framework. Angewandte Chemie International Edition. Wiley. https://doi.org/10.1002/anie.202404878 chicago: Sheng, Jinyu, Jacopo Perego, Silvia Bracco, Piotr Cieciórski, Wojciech Danowski, Angiolina Comotti, and Ben L. Feringa. “Orthogonal Photoswitching in a Porous Organic Framework.” Angewandte Chemie International Edition. Wiley, 2024. https://doi.org/10.1002/anie.202404878. ieee: J. Sheng et al., “Orthogonal photoswitching in a porous organic framework,” Angewandte Chemie International Edition, vol. 63, no. 23. Wiley, 2024. ista: Sheng J, Perego J, Bracco S, Cieciórski P, Danowski W, Comotti A, Feringa BL. 2024. Orthogonal photoswitching in a porous organic framework. Angewandte Chemie International Edition. 63(23), e202404878. mla: Sheng, Jinyu, et al. “Orthogonal Photoswitching in a Porous Organic Framework.” Angewandte Chemie International Edition, vol. 63, no. 23, e202404878, Wiley, 2024, doi:10.1002/anie.202404878. short: J. Sheng, J. Perego, S. Bracco, P. Cieciórski, W. Danowski, A. Comotti, B.L. Feringa, Angewandte Chemie International Edition 63 (2024). das_tickbox: '1' dataavailabilitystatement: The data that support the findings of this study are available in the supplementary material of this article. date_created: 2024-06-03T09:00:01Z date_published: 2024-03-26T00:00:00Z date_updated: 2026-09-17T10:32:51Z day: '26' ddc: - '540' department: - _id: RaKl doi: 10.1002/anie.202404878 external_id: pmid: - '38530132' file: - access_level: open_access checksum: 7ecb0892051f6ed8f6a6f25baa47543a content_type: application/pdf creator: dernst date_created: 2024-06-03T10:33:17Z date_updated: 2024-06-03T10:33:17Z file_id: '17107' file_name: 2024_AngChemieInt_Sheng.pdf file_size: 2363206 relation: main_file success: 1 file_date_updated: 2024-06-03T10:33:17Z fulldoi: https://doi.org/10.1002/anie.202404878 has_accepted_license: '1' intvolume: ' 63' issue: '23' language: - iso: eng month: '03' oa: 1 oa_version: Published Version pmid: 1 publication: Angewandte Chemie International Edition publication_identifier: eissn: - 1521-3773 issn: - 1433-7851 publication_status: published publisher: Wiley quality_controlled: '1' researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: yes title: Orthogonal photoswitching in a porous organic framework tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 63 year: '2024' ... --- OA_place: publisher OA_type: gold _id: '17054' abstract: - lang: eng text: Photoisomerization and photoluminescence are two distinct energy dissipation pathways in light-driven molecular motors. The photoisomerization properties of discrete molecular motors have been well established in solution, but their photoluminescent properties have been rarely reported—especially in aggregates. Here, it is shown that an overcrowded alkene-based molecular motor exhibits distinct dynamic properties in solution and aggregate states, for example, gel and solid states. Despite the poor emissive properties of molecular motors in solution, a bright emission is observed in the aggregate states, including in gel and the crystalline solid. The emission wavelength is highly dependent on the nature of the supramolecular packing and order in the aggregates. As a result, the fluorescent color can be readily tuned reversibly via mechanical grinding and vapor fuming, which provides a new platform for developing multi-stimuli functional materials. acknowledgement: This work was supported by the National Natural Science Foundation of China (grant nos. 22220102004, 22025503), Shanghai Municipal Science and Technology Major Project (grant no. 2018SHZDZX03), the Innovation Program of Shanghai Municipal Education Commission (2023ZKZD40), the Fundamental Research Funds for the Central Universities, the Program of Introducing Talents of Discipline to Universities (grant no. B16017), Science and Technology Commission of Shanghai Municipality (grant no. 21JC1401700), and the Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study (grant no. SN-ZJU-SIAS-006), China Scholarship Council (CSC PhD Fellowship No. 202006745016 to Yahan Shan). The authors gratefully acknowledge financial support from the Dutch Ministry of Education, Culture and Science (gravitation program no. 024.001.035 to Ben L. Feringa). The authors thank Dr. Youxin Fu and Dr. Alexander Ryabchun for the help with fluorescence quantum yield measurement, Cristina Nitu for the help with photoisomerzation quantum yield measurement, Prof. Wesley R. Browne for the help with fluorescence lifetime measurement, and Dr. Jianyu Zhang for fruitful discussion and revising the manuscript. article_number: e584 article_processing_charge: Yes article_type: original author: - first_name: Yahan full_name: Shan, Yahan last_name: Shan - first_name: Jinyu full_name: Sheng, Jinyu id: 639f0526-27c9-11ee-95a6-966cd7f102d8 last_name: Sheng - first_name: Qi full_name: Zhang, Qi last_name: Zhang - first_name: Marc C.A. full_name: Stuart, Marc C.A. last_name: Stuart - first_name: Da Hui full_name: Qu, Da Hui last_name: Qu - first_name: Ben L. full_name: Feringa, Ben L. last_name: Feringa citation: ama: Shan Y, Sheng J, Zhang Q, Stuart MCA, Qu DH, Feringa BL. Multi-state photoluminescent properties of an overcrowded alkene-based molecular motor in aggregates. Aggregate. 2024;5(5). doi:10.1002/agt2.584 apa: Shan, Y., Sheng, J., Zhang, Q., Stuart, M. C. A., Qu, D. H., & Feringa, B. L. (2024). Multi-state photoluminescent properties of an overcrowded alkene-based molecular motor in aggregates. Aggregate. Wiley. https://doi.org/10.1002/agt2.584 chicago: Shan, Yahan, Jinyu Sheng, Qi Zhang, Marc C.A. Stuart, Da Hui Qu, and Ben L. Feringa. “Multi-State Photoluminescent Properties of an Overcrowded Alkene-Based Molecular Motor in Aggregates.” Aggregate. Wiley, 2024. https://doi.org/10.1002/agt2.584. ieee: Y. Shan, J. Sheng, Q. Zhang, M. C. A. Stuart, D. H. Qu, and B. L. Feringa, “Multi-state photoluminescent properties of an overcrowded alkene-based molecular motor in aggregates,” Aggregate, vol. 5, no. 5. Wiley, 2024. ista: Shan Y, Sheng J, Zhang Q, Stuart MCA, Qu DH, Feringa BL. 2024. Multi-state photoluminescent properties of an overcrowded alkene-based molecular motor in aggregates. Aggregate. 5(5), e584. mla: Shan, Yahan, et al. “Multi-State Photoluminescent Properties of an Overcrowded Alkene-Based Molecular Motor in Aggregates.” Aggregate, vol. 5, no. 5, e584, Wiley, 2024, doi:10.1002/agt2.584. short: Y. Shan, J. Sheng, Q. Zhang, M.C.A. Stuart, D.H. Qu, B.L. Feringa, Aggregate 5 (2024). das_tickbox: '0' date_created: 2024-05-26T22:00:58Z date_published: 2024-10-01T00:00:00Z date_updated: 2026-09-17T11:01:40Z day: '01' ddc: - '540' department: - _id: RaKl doi: 10.1002/agt2.584 file: - access_level: open_access checksum: 1e79dc81d0edf0b441ef661a1890bbf5 content_type: application/pdf creator: dernst date_created: 2025-01-09T09:38:51Z date_updated: 2025-01-09T09:38:51Z file_id: '18804' file_name: 2024_Aggregate_Shan.pdf file_size: 2299084 relation: main_file success: 1 file_date_updated: 2025-01-09T09:38:51Z fulldoi: https://doi.org/10.1002/agt2.584 has_accepted_license: '1' intvolume: ' 5' issue: '5' language: - iso: eng month: '10' oa: 1 oa_version: Published Version publication: Aggregate publication_identifier: eissn: - 2692-4560 issn: - 2766-8541 publication_status: published publisher: Wiley quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: yes title: Multi-state photoluminescent properties of an overcrowded alkene-based molecular motor in aggregates tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 5 year: '2024' ... --- OA_type: closed access _id: '18310' article_processing_charge: No article_type: original author: - first_name: Maria full_name: Kitsara, Maria last_name: Kitsara - first_name: Merima full_name: Smajlhodžić-Deljo, Merima last_name: Smajlhodžić-Deljo - first_name: Lejla full_name: Gurbeta Pokvic, Lejla last_name: Gurbeta Pokvic - first_name: Bettina full_name: Bert, Bettina last_name: Bert - first_name: Nataliia full_name: Bubalo, Nataliia last_name: Bubalo - first_name: Sevilay full_name: Erden, Sevilay last_name: Erden - first_name: Nuno Henrique full_name: Franco, Nuno Henrique last_name: Franco - first_name: Giuseppe full_name: Chirico, Giuseppe last_name: Chirico - first_name: Jonathan full_name: Gómez Raja, Jonathan last_name: Gómez Raja - first_name: Fernando full_name: Gonzalez-Uarquin, Fernando last_name: Gonzalez-Uarquin - first_name: Annemarie full_name: Lang, Annemarie last_name: Lang - first_name: Nicole full_name: Linklater, Nicole last_name: Linklater - first_name: Sandra full_name: Mojsova, Sandra last_name: Mojsova - first_name: I. Anna S. full_name: Olsson, I. Anna S. last_name: Olsson - first_name: Ioanna full_name: Sandvig, Ioanna last_name: Sandvig - first_name: Alexandra full_name: Schaffert, Alexandra last_name: Schaffert - first_name: Marthe full_name: Schmit, Marthe last_name: Schmit - first_name: Sophie full_name: Schober, Sophie id: 80b0a0ef-4b9f-11ec-b119-8d9d94c4a1d8 last_name: Schober - first_name: Bogdan full_name: Sevastre, Bogdan last_name: Sevastre - first_name: Doris full_name: Wilflingseder, Doris last_name: Wilflingseder - first_name: Arti full_name: Ahluwalia, Arti last_name: Ahluwalia - first_name: Winfried full_name: Neuhaus, Winfried last_name: Neuhaus citation: ama: Kitsara M, Smajlhodžić-Deljo M, Gurbeta Pokvic L, et al. Introducing the COST action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE). Alternatives to Laboratory Animals. 2024;52(6):326-333. doi:10.1177/02611929241286024 apa: Kitsara, M., Smajlhodžić-Deljo, M., Gurbeta Pokvic, L., Bert, B., Bubalo, N., Erden, S., … Neuhaus, W. (2024). Introducing the COST action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE). Alternatives to Laboratory Animals. SAGE Publications. https://doi.org/10.1177/02611929241286024 chicago: Kitsara, Maria, Merima Smajlhodžić-Deljo, Lejla Gurbeta Pokvic, Bettina Bert, Nataliia Bubalo, Sevilay Erden, Nuno Henrique Franco, et al. “Introducing the COST Action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE).” Alternatives to Laboratory Animals. SAGE Publications, 2024. https://doi.org/10.1177/02611929241286024. ieee: M. Kitsara et al., “Introducing the COST action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE),” Alternatives to Laboratory Animals, vol. 52, no. 6. SAGE Publications, pp. 326–333, 2024. ista: Kitsara M, Smajlhodžić-Deljo M, Gurbeta Pokvic L, Bert B, Bubalo N, Erden S, Franco NH, Chirico G, Gómez Raja J, Gonzalez-Uarquin F, Lang A, Linklater N, Mojsova S, Olsson IAS, Sandvig I, Schaffert A, Schmit M, Schober S, Sevastre B, Wilflingseder D, Ahluwalia A, Neuhaus W. 2024. Introducing the COST action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE). Alternatives to Laboratory Animals. 52(6), 326–333. mla: Kitsara, Maria, et al. “Introducing the COST Action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE).” Alternatives to Laboratory Animals, vol. 52, no. 6, SAGE Publications, 2024, pp. 326–33, doi:10.1177/02611929241286024. short: M. Kitsara, M. Smajlhodžić-Deljo, L. Gurbeta Pokvic, B. Bert, N. Bubalo, S. Erden, N.H. Franco, G. Chirico, J. Gómez Raja, F. Gonzalez-Uarquin, A. Lang, N. Linklater, S. Mojsova, I.A.S. Olsson, I. Sandvig, A. Schaffert, M. Schmit, S. Schober, B. Sevastre, D. Wilflingseder, A. Ahluwalia, W. Neuhaus, Alternatives to Laboratory Animals 52 (2024) 326–333. das_tickbox: '0' date_created: 2024-10-13T22:01:51Z date_published: 2024-11-01T00:00:00Z date_updated: 2026-09-17T10:30:08Z day: '01' department: - _id: PreCl doi: 10.1177/02611929241286024 external_id: isi: - '001348633700007' pmid: - '39333027' fulldoi: https://doi.org/10.1177/02611929241286024 intvolume: ' 52' isi: 1 issue: '6' language: - iso: eng month: '11' oa_version: None page: 326-333 pmid: 1 publication: Alternatives to Laboratory Animals publication_identifier: eissn: - 2632-3559 issn: - 0261-1929 publication_status: published publisher: SAGE Publications quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: no title: Introducing the COST action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 52 year: '2024' ... --- _id: '15318' abstract: - lang: eng text: We consider a gas of N weakly interacting bosons in the ground state. Such gases exhibit Bose–Einstein condensation. The binding energy is defined as the energy it takes to remove one particle from the gas. In this article, we prove an asymptotic expansion for the binding energy, and compute the first orders explicitly for the homogeneous gas. Our result addresses in particular a conjecture by Nam (Lett Math Phys 108(1):141–159, 2018), and provides an asymptotic expansion of the ionization energy of bosonic atoms. acknowledgement: "It is a pleasure to thank Phan Thành Nam for helpful discussions on bosonic atoms. L.B. was supported by the German Research Foundation within the Munich Center of Quantum Science and Technology (EXC 2111). N.L. gratefully acknowledges support from the Swiss National Science Foundation through the NCCR SwissMap and funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant agreement No 101024712. S.P. acknowledges funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)—Project number 512258249.\r\nOpen Access funding enabled and organized by Projekt DEAL." article_number: '48' article_processing_charge: Yes (via OA deal) article_type: original arxiv: 1 author: - first_name: Lea full_name: Bossmann, Lea id: A2E3BCBE-5FCC-11E9-AA4B-76F3E5697425 last_name: Bossmann orcid: 0000-0002-6854-1343 - first_name: Nikolai K full_name: Leopold, Nikolai K id: 4BC40BEC-F248-11E8-B48F-1D18A9856A87 last_name: Leopold orcid: 0000-0002-0495-6822 - first_name: David Johannes full_name: Mitrouskas, David Johannes id: cbddacee-2b11-11eb-a02e-a2e14d04e52d last_name: Mitrouskas - first_name: Sören P full_name: Petrat, Sören P id: 40AC02DC-F248-11E8-B48F-1D18A9856A87 last_name: Petrat orcid: 0000-0002-9166-5889 citation: ama: Bossmann L, Leopold NK, Mitrouskas DJ, Petrat SP. A note on the binding energy for Bosons in the mean-field limit. Journal of Statistical Physics. 2024;191(4). doi:10.1007/s10955-024-03260-5 apa: Bossmann, L., Leopold, N. K., Mitrouskas, D. J., & Petrat, S. P. (2024). A note on the binding energy for Bosons in the mean-field limit. Journal of Statistical Physics. Springer Nature. https://doi.org/10.1007/s10955-024-03260-5 chicago: Bossmann, Lea, Nikolai K Leopold, David Johannes Mitrouskas, and Sören P Petrat. “A Note on the Binding Energy for Bosons in the Mean-Field Limit.” Journal of Statistical Physics. Springer Nature, 2024. https://doi.org/10.1007/s10955-024-03260-5. ieee: L. Bossmann, N. K. Leopold, D. J. Mitrouskas, and S. P. Petrat, “A note on the binding energy for Bosons in the mean-field limit,” Journal of Statistical Physics, vol. 191, no. 4. Springer Nature, 2024. ista: Bossmann L, Leopold NK, Mitrouskas DJ, Petrat SP. 2024. A note on the binding energy for Bosons in the mean-field limit. Journal of Statistical Physics. 191(4), 48. mla: Bossmann, Lea, et al. “A Note on the Binding Energy for Bosons in the Mean-Field Limit.” Journal of Statistical Physics, vol. 191, no. 4, 48, Springer Nature, 2024, doi:10.1007/s10955-024-03260-5. short: L. Bossmann, N.K. Leopold, D.J. Mitrouskas, S.P. Petrat, Journal of Statistical Physics 191 (2024). das_tickbox: '1' dataavailabilitystatement: Data sharing not applicable to this article as no datasets were generated or analyzed during the current study. date_created: 2024-04-14T22:01:02Z date_published: 2024-04-06T00:00:00Z date_updated: 2026-09-17T11:05:18Z day: '06' ddc: - '510' department: - _id: RoSe doi: 10.1007/s10955-024-03260-5 external_id: arxiv: - '2307.13115' isi: - '001197663100002' file: - access_level: open_access checksum: 839242a9ec1c01158112de25f196e60d content_type: application/pdf creator: dernst date_created: 2024-04-16T11:09:37Z date_updated: 2024-04-16T11:09:37Z file_id: '15325' file_name: 2024_JourStatPhysics_Bossmann.pdf file_size: 398665 relation: main_file success: 1 file_date_updated: 2024-04-16T11:09:37Z fulldoi: https://doi.org/10.1007/s10955-024-03260-5 has_accepted_license: '1' intvolume: ' 191' isi: 1 issue: '4' language: - iso: eng month: '04' oa: 1 oa_version: Published Version publication: Journal of Statistical Physics publication_identifier: eissn: - 1572-9613 issn: - 0022-4715 publication_status: published publisher: Springer Nature quality_controlled: '1' researchdata_availability: not applicable scopus_import: '1' status: public supplementarymaterial: no title: A note on the binding energy for Bosons in the mean-field limit tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 191 year: '2024' ... --- OA_place: publisher OA_type: hybrid _id: '17478' abstract: - lang: eng text: "We study the Fröhlich polaron model in R3, and prove a lower bound on its ground state energy as a function of the total momentum. The bound is asymptotically sharp at large coupling. In combination with a corresponding upper bound proved earlier (Mitrouskas et al. in Forum Math. Sigma 11:1–52, 2023), it shows that the energy is approximately parabolic below the continuum threshold, and that the polaron’s effective mass (defined as the semi-latus rectum of the\r\nparabola) is given by the celebrated Landau–Pekar formula. In particular, it diverges as α4 for large coupling constant α." article_processing_charge: Yes (in subscription journal) article_type: original arxiv: 1 author: - first_name: Morris full_name: Brooks, Morris id: B7ECF9FC-AA38-11E9-AC9A-0930E6697425 last_name: Brooks orcid: 0000-0002-6249-0928 - first_name: Robert full_name: Seiringer, Robert id: 4AFD0470-F248-11E8-B48F-1D18A9856A87 last_name: Seiringer orcid: 0000-0002-6781-0521 citation: ama: 'Brooks M, Seiringer R. The Fröhlich polaron at strong coupling: Part II — Energy-momentum relation and effective mass. Publications Mathematiques de l’Institut des Hautes Etudes Scientifiques. 2024;140:271-309. doi:10.1007/s10240-024-00150-0' apa: 'Brooks, M., & Seiringer, R. (2024). The Fröhlich polaron at strong coupling: Part II — Energy-momentum relation and effective mass. Publications Mathematiques de l’Institut Des Hautes Etudes Scientifiques. Springer Nature. https://doi.org/10.1007/s10240-024-00150-0' chicago: 'Brooks, Morris, and Robert Seiringer. “The Fröhlich Polaron at Strong Coupling: Part II — Energy-Momentum Relation and Effective Mass.” Publications Mathematiques de l’Institut Des Hautes Etudes Scientifiques. Springer Nature, 2024. https://doi.org/10.1007/s10240-024-00150-0.' ieee: 'M. Brooks and R. Seiringer, “The Fröhlich polaron at strong coupling: Part II — Energy-momentum relation and effective mass,” Publications Mathematiques de l’Institut des Hautes Etudes Scientifiques, vol. 140. Springer Nature, pp. 271–309, 2024.' ista: 'Brooks M, Seiringer R. 2024. The Fröhlich polaron at strong coupling: Part II — Energy-momentum relation and effective mass. Publications Mathematiques de l’Institut des Hautes Etudes Scientifiques. 140, 271–309.' mla: 'Brooks, Morris, and Robert Seiringer. “The Fröhlich Polaron at Strong Coupling: Part II — Energy-Momentum Relation and Effective Mass.” Publications Mathematiques de l’Institut Des Hautes Etudes Scientifiques, vol. 140, Springer Nature, 2024, pp. 271–309, doi:10.1007/s10240-024-00150-0.' short: M. Brooks, R. Seiringer, Publications Mathematiques de l’Institut Des Hautes Etudes Scientifiques 140 (2024) 271–309. corr_author: '1' das_tickbox: '0' date_created: 2024-09-01T22:01:08Z date_published: 2024-12-01T00:00:00Z date_updated: 2026-09-17T11:07:19Z day: '01' ddc: - '510' department: - _id: RoSe doi: 10.1007/s10240-024-00150-0 external_id: arxiv: - '2211.03353' isi: - '001297785000001' file: - access_level: open_access checksum: af3becc50f7534c9409d3ff8b5c47ed6 content_type: application/pdf creator: dernst date_created: 2025-01-13T08:13:42Z date_updated: 2025-01-13T08:13:42Z file_id: '18824' file_name: 2024_PublicMathIHES_Brooks.pdf file_size: 924342 relation: main_file success: 1 file_date_updated: 2025-01-13T08:13:42Z fulldoi: https://doi.org/10.1007/s10240-024-00150-0 has_accepted_license: '1' intvolume: ' 140' isi: 1 language: - iso: eng month: '12' oa: 1 oa_version: Published Version page: 271-309 publication: Publications Mathematiques de l'Institut des Hautes Etudes Scientifiques publication_identifier: eissn: - 1618-1913 issn: - 0073-8301 publication_status: published publisher: Springer Nature quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: yes title: 'The Fröhlich polaron at strong coupling: Part II — Energy-momentum relation and effective mass' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 140 year: '2024' ... --- OA_place: repository OA_type: green _id: '18948' abstract: - lang: eng text: We consider a gas of N bosons with interactions in the mean-field scaling regime. We review a recent proof of the asymptotic expansion of its spectrum and eigenstates and two applications of this result, namely the derivation of an Edgeworth expansion for fluctuations of one-body operators and the computation of the binding energy of an inhomogeneous Bose gas to any order. Finally, we collect related results for the dynamics of the weakly interacting Bose gas and for the regularized Nelson model. acknowledgement: It is our pleasure to thank Marco Falconi, Nataša Pavlović, Peter Pickl, Robert Seiringer and Avy Soffer for the collaboration on the works [11, 13, 14, 21, 33, 39]. L.B. was supported by the German Research Foundation within the Munich Center of Quantum Science and Technology (EXC 2111). N.L. acknowledges support from the Swiss National Science Foundation through the NCCR SwissMap and funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101024712. S.P. acknowledges funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - project number 512258249. alternative_title: - Fundamental Theories of Physics article_processing_charge: No arxiv: 1 author: - first_name: Lea full_name: Bossmann, Lea id: A2E3BCBE-5FCC-11E9-AA4B-76F3E5697425 last_name: Bossmann orcid: 0000-0002-6854-1343 - first_name: Nikolai full_name: Leopold, Nikolai last_name: Leopold - first_name: David Johannes full_name: Mitrouskas, David Johannes id: cbddacee-2b11-11eb-a02e-a2e14d04e52d last_name: Mitrouskas - first_name: Sören full_name: Petrat, Sören last_name: Petrat citation: ama: 'Bossmann L, Leopold N, Mitrouskas DJ, Petrat S. Asymptotic Analysis of the Weakly Interacting Bose Gas: A Collection of Recent Results and Applications. In: Bassi A, Goldstein S, Tumulka R, Zanghi N, eds. Physics and the Nature of Reality. Vol 215. FTPH. Cham: Springer Nature; 2024:307-321. doi:10.1007/978-3-031-45434-9_22' apa: 'Bossmann, L., Leopold, N., Mitrouskas, D. J., & Petrat, S. (2024). Asymptotic Analysis of the Weakly Interacting Bose Gas: A Collection of Recent Results and Applications. In A. Bassi, S. Goldstein, R. Tumulka, & N. Zanghi (Eds.), Physics and the Nature of Reality (Vol. 215, pp. 307–321). Cham: Springer Nature. https://doi.org/10.1007/978-3-031-45434-9_22' chicago: 'Bossmann, Lea, Nikolai Leopold, David Johannes Mitrouskas, and Sören Petrat. “Asymptotic Analysis of the Weakly Interacting Bose Gas: A Collection of Recent Results and Applications.” In Physics and the Nature of Reality, edited by Angelo Bassi, Sheldon Goldstein, Roderich Tumulka, and Nino Zanghi, 215:307–21. FTPH. Cham: Springer Nature, 2024. https://doi.org/10.1007/978-3-031-45434-9_22.' ieee: 'L. Bossmann, N. Leopold, D. J. Mitrouskas, and S. Petrat, “Asymptotic Analysis of the Weakly Interacting Bose Gas: A Collection of Recent Results and Applications,” in Physics and the Nature of Reality, vol. 215, A. Bassi, S. Goldstein, R. Tumulka, and N. Zanghi, Eds. Cham: Springer Nature, 2024, pp. 307–321.' ista: 'Bossmann L, Leopold N, Mitrouskas DJ, Petrat S. 2024.Asymptotic Analysis of the Weakly Interacting Bose Gas: A Collection of Recent Results and Applications. In: Physics and the Nature of Reality. Fundamental Theories of Physics, vol. 215, 307–321.' mla: 'Bossmann, Lea, et al. “Asymptotic Analysis of the Weakly Interacting Bose Gas: A Collection of Recent Results and Applications.” Physics and the Nature of Reality, edited by Angelo Bassi et al., vol. 215, Springer Nature, 2024, pp. 307–21, doi:10.1007/978-3-031-45434-9_22.' short: L. Bossmann, N. Leopold, D.J. Mitrouskas, S. Petrat, in:, A. Bassi, S. Goldstein, R. Tumulka, N. Zanghi (Eds.), Physics and the Nature of Reality, Springer Nature, Cham, 2024, pp. 307–321. das_tickbox: '0' date_created: 2025-01-29T10:30:08Z date_published: 2024-02-04T00:00:00Z date_updated: 2026-09-17T11:08:01Z day: '04' department: - _id: RoSe doi: 10.1007/978-3-031-45434-9_22 editor: - first_name: Angelo full_name: Bassi, Angelo last_name: Bassi - first_name: Sheldon full_name: Goldstein, Sheldon last_name: Goldstein - first_name: Roderich full_name: Tumulka, Roderich last_name: Tumulka - first_name: Nino full_name: Zanghi, Nino last_name: Zanghi external_id: arxiv: - '2304.12910' fulldoi: https://doi.org/10.1007/978-3-031-45434-9_22 intvolume: ' 215' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2304.12910 month: '02' oa: 1 oa_version: Preprint page: 307-321 place: Cham publication: Physics and the Nature of Reality publication_identifier: eisbn: - '9783031454349' eissn: - 2365-6425 isbn: - '9783031454332' issn: - 0168-1222 publication_status: published publisher: Springer Nature quality_controlled: '1' researchdata_availability: no scopus_import: '1' series_title: FTPH status: public supplementarymaterial: no title: 'Asymptotic Analysis of the Weakly Interacting Bose Gas: A Collection of Recent Results and Applications' type: book_chapter user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 215 year: '2024' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '17457' abstract: - lang: eng text: "Autoantibodies against the protein leucine-rich glioma inactivated 1 (LGI1) cause the most\r\ncommon subtype of autoimmune encephalitis with predominant involvement of the limbic\r\nsystem, associated with seizures and memory deficits. LGI1 and its receptor ADAM22 are part\r\nof a transsynaptic protein complex that includes several proteins involved in presynaptic\r\nneurotransmitter release and postsynaptic glutamate sensing. Autoantibodies against LGI1\r\nincrease excitatory synaptic strength, but studies that genetically disrupt the LGI1-ADAM22\r\ncomplex report a reduction in postsynaptic glutamate receptor-mediated responses. Thus, the\r\nmechanisms underlying the increased synaptic strength induced by LGI1 autoantibodies remain elusive, and the contributions of presynaptic molecules to the LGI1-transsynaptic complex remain unclear. We therefore investigated the presynaptic mechanisms that mediate\r\nautoantibody-induced synaptic strengthening." acknowledged_ssus: - _id: Bio - _id: EM-Fac acknowledgement: 'The authors thank Claudia Sommer for expert technical assistance, the Electron Microscopy Facility of IST-Austria for resources, and Tereza Belinova in the Imaging and Optics Facility of IST-Austria for 3D reconstruction. ' article_processing_charge: Yes article_type: original author: - first_name: Andreas full_name: Ritzau-Jost, Andreas last_name: Ritzau-Jost - first_name: Felix full_name: Gsell, Felix last_name: Gsell - first_name: Josefine full_name: Sell, Josefine last_name: Sell - first_name: Stefan full_name: Sachs, Stefan last_name: Sachs - first_name: Jacqueline-Claire full_name: Montanaro-Punzengruber, Jacqueline-Claire id: 3786AB44-F248-11E8-B48F-1D18A9856A87 last_name: Montanaro-Punzengruber - first_name: Toni full_name: Kirmann, Toni last_name: Kirmann - first_name: Sebastian full_name: Maaß, Sebastian last_name: Maaß - first_name: Sarosh R. full_name: Irani, Sarosh R. last_name: Irani - first_name: Christian full_name: Werner, Christian last_name: Werner - first_name: Christian full_name: Geis, Christian last_name: Geis - first_name: Markus full_name: Sauer, Markus last_name: Sauer - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Stefan full_name: Hallermann, Stefan last_name: Hallermann citation: ama: Ritzau-Jost A, Gsell F, Sell J, et al. LGI1 autoantibodies enhance synaptic transmission by presynaptic Kv1 loss and increased action potential broadening. Neurology, Neuroimmunology & Neuroinflammation. 2024;11(5):e200284. doi:10.1212/NXI.0000000000200284 apa: Ritzau-Jost, A., Gsell, F., Sell, J., Sachs, S., Montanaro-Punzengruber, J.-C., Kirmann, T., … Hallermann, S. (2024). LGI1 autoantibodies enhance synaptic transmission by presynaptic Kv1 loss and increased action potential broadening. Neurology, Neuroimmunology & Neuroinflammation. Wolters Kluwer. https://doi.org/10.1212/NXI.0000000000200284 chicago: Ritzau-Jost, Andreas, Felix Gsell, Josefine Sell, Stefan Sachs, Jacqueline-Claire Montanaro-Punzengruber, Toni Kirmann, Sebastian Maaß, et al. “LGI1 Autoantibodies Enhance Synaptic Transmission by Presynaptic Kv1 Loss and Increased Action Potential Broadening.” Neurology, Neuroimmunology & Neuroinflammation. Wolters Kluwer, 2024. https://doi.org/10.1212/NXI.0000000000200284. ieee: A. Ritzau-Jost et al., “LGI1 autoantibodies enhance synaptic transmission by presynaptic Kv1 loss and increased action potential broadening,” Neurology, Neuroimmunology & Neuroinflammation, vol. 11, no. 5. Wolters Kluwer, p. e200284, 2024. ista: Ritzau-Jost A, Gsell F, Sell J, Sachs S, Montanaro-Punzengruber J-C, Kirmann T, Maaß S, Irani SR, Werner C, Geis C, Sauer M, Shigemoto R, Hallermann S. 2024. LGI1 autoantibodies enhance synaptic transmission by presynaptic Kv1 loss and increased action potential broadening. Neurology, Neuroimmunology & Neuroinflammation. 11(5), e200284. mla: Ritzau-Jost, Andreas, et al. “LGI1 Autoantibodies Enhance Synaptic Transmission by Presynaptic Kv1 Loss and Increased Action Potential Broadening.” Neurology, Neuroimmunology & Neuroinflammation, vol. 11, no. 5, Wolters Kluwer, 2024, p. e200284, doi:10.1212/NXI.0000000000200284. short: A. Ritzau-Jost, F. Gsell, J. Sell, S. Sachs, J.-C. Montanaro-Punzengruber, T. Kirmann, S. Maaß, S.R. Irani, C. Werner, C. Geis, M. Sauer, R. Shigemoto, S. Hallermann, Neurology, Neuroimmunology & Neuroinflammation 11 (2024) e200284. das_tickbox: '1' dataavailabilitystatement: Data that support the findings of this study are available from the corresponding author on reasonable request. date_created: 2024-08-25T22:01:07Z date_published: 2024-09-01T00:00:00Z date_updated: 2026-09-17T11:27:41Z day: '01' ddc: - '570' department: - _id: RySh doi: 10.1212/NXI.0000000000200284 external_id: isi: - '001291908600001' pmid: - '39141878' file: - access_level: open_access checksum: 1e6d1230e0387f72752e3268f5330c9e content_type: application/pdf creator: dernst date_created: 2025-01-09T13:42:42Z date_updated: 2025-01-09T13:42:42Z file_id: '18815' file_name: 2024_NeurologyNeuroimmNeuroinflamm_RitzauJost.pdf file_size: 855818 relation: main_file success: 1 file_date_updated: 2025-01-09T13:42:42Z fulldoi: https://doi.org/10.1212/NXI.0000000000200284 has_accepted_license: '1' intvolume: ' 11' isi: 1 issue: '5' language: - iso: eng month: '09' oa: 1 oa_version: Published Version page: e200284 pmid: 1 project: - _id: 05970B30-7A3F-11EA-A408-12923DDC885E grant_number: I04638 name: LGI1 antibody-induced pathophysiology in synapses publication: Neurology, Neuroimmunology & Neuroinflammation publication_identifier: eissn: - 2332-7812 publication_status: published publisher: Wolters Kluwer quality_controlled: '1' related_material: link: - relation: earlier_version url: https://doi.org/10.1101/2023.10.04.560631 researchdata_availability: upon request scopus_import: '1' status: public supplementarymaterial: yes title: LGI1 autoantibodies enhance synaptic transmission by presynaptic Kv1 loss and increased action potential broadening tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 11 year: '2024' ... --- _id: '18958' abstract: - lang: eng text: This workshop brought together experts on the analysis of quantum many-body problems and quantum statistical mechanics, with the goal of discussing the state-of-the-art of the field, recent developments as well as challenges for the future. The main topics of discussion concerned the equilibrium and dynamical behavior of (bosonic or fermionic) quantum gases, quantum spin systems, as well as quantum field theory models like the Nelson or Fröhlich model. acknowledgement: The MFO and the workshop organizers would like to thank the National Science Foundation for supporting the participation of junior researchers in the workshop by the grant DMS-2230648, “US Junior Oberwolfach Fellows”. article_processing_charge: No article_type: original author: - first_name: Christian full_name: Hainzl, Christian last_name: Hainzl - first_name: Benjamin full_name: Schlein, Benjamin last_name: Schlein - first_name: Robert full_name: Seiringer, Robert id: 4AFD0470-F248-11E8-B48F-1D18A9856A87 last_name: Seiringer orcid: 0000-0002-6781-0521 - first_name: Simone full_name: Warzel, Simone last_name: Warzel citation: ama: Hainzl C, Schlein B, Seiringer R, Warzel S. Many-body quantum systems. Oberwolfach Reports. 2024;20(3):2247-2302. doi:10.4171/owr/2023/39 apa: Hainzl, C., Schlein, B., Seiringer, R., & Warzel, S. (2024). Many-body quantum systems. Oberwolfach Reports. EMS Press. https://doi.org/10.4171/owr/2023/39 chicago: Hainzl, Christian, Benjamin Schlein, Robert Seiringer, and Simone Warzel. “Many-Body Quantum Systems.” Oberwolfach Reports. EMS Press, 2024. https://doi.org/10.4171/owr/2023/39. ieee: C. Hainzl, B. Schlein, R. Seiringer, and S. Warzel, “Many-body quantum systems,” Oberwolfach Reports, vol. 20, no. 3. EMS Press, pp. 2247–2302, 2024. ista: Hainzl C, Schlein B, Seiringer R, Warzel S. 2024. Many-body quantum systems. Oberwolfach Reports. 20(3), 2247–2302. mla: Hainzl, Christian, et al. “Many-Body Quantum Systems.” Oberwolfach Reports, vol. 20, no. 3, EMS Press, 2024, pp. 2247–302, doi:10.4171/owr/2023/39. short: C. Hainzl, B. Schlein, R. Seiringer, S. Warzel, Oberwolfach Reports 20 (2024) 2247–2302. das_tickbox: '0' date_created: 2025-01-29T13:09:28Z date_published: 2024-04-18T00:00:00Z date_updated: 2026-09-17T11:09:16Z day: '18' department: - _id: RoSe doi: 10.4171/owr/2023/39 fulldoi: https://doi.org/10.4171/owr/2023/39 intvolume: ' 20' issue: '3' language: - iso: eng month: '04' oa_version: None page: 2247-2302 publication: Oberwolfach Reports publication_identifier: eissn: - 1660-8941 issn: - 1660-8933 publication_status: published publisher: EMS Press quality_controlled: '1' researchdata_availability: no status: public supplementarymaterial: no title: Many-body quantum systems type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 20 year: '2024' ...