---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21753'
abstract:
- lang: eng
text: The origin(s) of life (OoL), which has puzzled scientists for centuries, remains
a major scientific challenge in the 21st century. Understanding the processes
relevant to the OoL demands theoretical frameworks that can connect processes
across scales, from microscopic dynamics to emergent levels of organization. While
experimental studies generate a wealth of data, theoretical and computational
approaches provide the structure necessary to interpret and generalize these findings.
In Part 1, we examined the most widely used experimental techniques in the field.
Here, we focus on the mathematical, physical, and computational techniques used
to model phenomena relevant to life’s origin(s). We discuss methods ranging from
quantum chemistry and molecular dynamics to chemical reaction networks, autocatalysis,
and evolutionary modeling, as well as information-theoretic and phylogenetic approaches
that link chemical and biological organization. We further highlight emerging
trends such as synthetic biology, omics-based methods, and laboratory automation
as novel points of contact for theory-experiment integration. Ultimately, we aim
to provide an educational tool that can facilitate more post-disciplinary collaborations
in OoL research by helping scientists understand what they can do about the problem
of life’s origins, rather than telling them how to think about it.
acknowledgement: This work is a collaborative effort of the titled authors as part
of the Origin of Life Early Career Network (OoLEN). We chose to add OoLEN as the
first author to give a better representation of this team effort, rather than listing
any single author as the first author. We hope such a thing can be adopted by others.
We indicate that authors 2–9 (S.A., C.B., C. Blanco, D.B., A.C.-R., C.M., O.M.,
Z.P., and A.V.D.) have made a more distinct contribution. All authors are listed
alphabetically by their last names. We would like to acknowledge all current and
past members of OoLEN for their contributions to our community. In particular, we
would like to acknowledge Evrim Fer, who helped with molecular phylogenetics. We
would like to thank the anonymous referees for reviewing Parts 1 and 2 of this manuscript;
this work was significantly improved through their feedback. S.A. acknowledges support
from NASA through the postdoctoral Program at GSFC. C. Bautista acknowledges support
from “la Caixa” Foundation (ID 100010434) under agreement (LCF/BQ/AA16/11580051)
and by the Fonds de recherche du Québec Nature et technologies (FRQNT) (#274987).
C. Blanco acknowledges support from NASA under award 80NSSC21K0595. D.B. acknowledges
support from Centre national d'études spatiales (CNES) and postdoctoral support
from LGPM-CentralSupélec and NASA under award 80NSSC23K1477. E. Camprubi acknowledges
support from UT System for a STARs award. A.C.-R. acknowledges funding from the
Natural Sciences and Engineering Research Council of Canada (grant number RGPIN/05278–2018),
the Fonds de recherche Nature et Technologies of Québec (grant number 314488), and
the Fondation J. Armand Bombardier Excellence Scholarship. A.C.-R.’s research was
supported by an appointment to the NASA Postdoctoral Program from the NASA Astrobiology
Program administered by Oak Ridge Associated Universities under contract with NASA.
S.F.J. acknowledges support from “la Caixa” Foundation (ID 100010434) and from the
European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska
Curie grant agreement no. 847648 (the fellowship code is LCF/BQ/PI21/11830015).
T.Z.J. acknowledges support from Japan Society for the Promotion of Science (JSPS)
grants-in-aid 18K14354 and 21K14746, a Tokyo Institute of Technology Yoshinori Ohsumi
Fund for Fundamental Research, the Mizuho Foundation for the Promotion of Sciences,
and by the Temporary Assistant Program by the DE&I Section of Science Tokyo. A.K.
acknowledges support from the European Union’s Horizon 2020 research and innovation
program under the Marie Skłodowska-Curie Grant agreement no. 101068029. C.M. acknowledges
support from NASA through the postdoctoral Fellowship Program. The views and conclusions
contained in this document are those of the authors and should not be interpreted
as representing the official policies, either expressed or implied, of NASA. O.M.
acknowledges support from The John Templeton Foundation (#62828) and the Foundation
for Science and Technology (2023.05971.CEECIND). B.K.D.P. acknowledges support from
the NSERC Banting Postdoctoral Fellowship. K.P. acknowledges financial support from
the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s
Excellence Strategy EXC 2181/1 - 390900948 (the Heidelberg STRUCTURES Excellence
Cluster) and is a fellow of the International Max Planck Research School for Astronomy
and Cosmic Physics at the University of Heidelberg (IMPRS-HD).
article_number: '103211'
article_processing_charge: Yes
article_type: original
author:
- first_name: Silke
full_name: Asche, Silke
last_name: Asche
- first_name: Carla
full_name: Bautista, Carla
last_name: Bautista
- first_name: Celia
full_name: Blanco, Celia
last_name: Blanco
- first_name: David
full_name: Boulesteix, David
last_name: Boulesteix
- first_name: Alexandre
full_name: Champagne-Ruel, Alexandre
last_name: Champagne-Ruel
- first_name: Cole
full_name: Mathis, Cole
last_name: Mathis
- first_name: Omer
full_name: Markovitch, Omer
last_name: Markovitch
- first_name: Zhen
full_name: Peng, Zhen
last_name: Peng
- first_name: Avinash Vicholous
full_name: Dass, Avinash Vicholous
last_name: Dass
- first_name: Alyssa
full_name: Adams, Alyssa
last_name: Adams
- first_name: Eloi
full_name: Camprubi, Eloi
last_name: Camprubi
- first_name: Enrico Sandro
full_name: Colizzi, Enrico Sandro
last_name: Colizzi
- first_name: Stephanie
full_name: Colón-Santos, Stephanie
last_name: Colón-Santos
- first_name: Hannah
full_name: Dromiack, Hannah
last_name: Dromiack
- first_name: Valentina
full_name: Erastova, Valentina
last_name: Erastova
- first_name: Amanda
full_name: Garcia, Amanda
last_name: Garcia
- first_name: Ghjuvan
full_name: Grimaud, Ghjuvan
last_name: Grimaud
- first_name: Aaron
full_name: Halpern, Aaron
last_name: Halpern
- first_name: Stuart A.
full_name: Harrison, Stuart A.
last_name: Harrison
- first_name: Seán F.
full_name: Jordan, Seán F.
last_name: Jordan
- first_name: Tony Z.
full_name: Jia, Tony Z.
last_name: Jia
- first_name: Amit
full_name: Kahana, Amit
last_name: Kahana
- first_name: Artemy
full_name: Kolchinsky, Artemy
last_name: Kolchinsky
- first_name: Odin
full_name: Moron-Garcia, Odin
last_name: Moron-Garcia
- first_name: Ryo
full_name: Mizuuchi, Ryo
last_name: Mizuuchi
- first_name: Jingbo
full_name: Nan, Jingbo
last_name: 'Nan'
- first_name: Yuliia
full_name: Orlova, Yuliia
last_name: Orlova
- first_name: Ben K.D.
full_name: Pearce, Ben K.D.
last_name: Pearce
- first_name: Klaus
full_name: Paschek, Klaus
last_name: Paschek
- first_name: Martina
full_name: Preiner, Martina
last_name: Preiner
- first_name: Silvana
full_name: Pinna, Silvana
last_name: Pinna
- first_name: Eduardo
full_name: Rodríguez-Román, Eduardo
last_name: Rodríguez-Román
- first_name: Loraine
full_name: Schwander, Loraine
last_name: Schwander
- first_name: Siddhant
full_name: Sharma, Siddhant
id: 36996868-4916-11f1-8c9d-c0c901467b61
last_name: Sharma
- first_name: Harrison B.
full_name: Smith, Harrison B.
last_name: Smith
- first_name: Andrey
full_name: Vieira, Andrey
last_name: Vieira
- first_name: Joana C.
full_name: Xavier, Joana C.
last_name: Xavier
citation:
ama: 'Asche S, Bautista C, Blanco C, et al. What it takes to solve the origins of
life: An integrated review. Part 2: Theoretical methods and emerging trends. Cell
Reports Physical Science. 2026;7(4). doi:10.1016/j.xcrp.2026.103211'
apa: 'Asche, S., Bautista, C., Blanco, C., Boulesteix, D., Champagne-Ruel, A., Mathis,
C., … Xavier, J. C. (2026). What it takes to solve the origins of life: An integrated
review. Part 2: Theoretical methods and emerging trends. Cell Reports Physical
Science. Elsevier. https://doi.org/10.1016/j.xcrp.2026.103211'
chicago: 'Asche, Silke, Carla Bautista, Celia Blanco, David Boulesteix, Alexandre
Champagne-Ruel, Cole Mathis, Omer Markovitch, et al. “What It Takes to Solve the
Origins of Life: An Integrated Review. Part 2: Theoretical Methods and Emerging
Trends.” Cell Reports Physical Science. Elsevier, 2026. https://doi.org/10.1016/j.xcrp.2026.103211.'
ieee: 'S. Asche et al., “What it takes to solve the origins of life: An integrated
review. Part 2: Theoretical methods and emerging trends,” Cell Reports Physical
Science, vol. 7, no. 4. Elsevier, 2026.'
ista: 'Asche S, Bautista C, Blanco C, Boulesteix D, Champagne-Ruel A, Mathis C,
Markovitch O, Peng Z, Dass AV, Adams A, Camprubi E, Colizzi ES, Colón-Santos S,
Dromiack H, Erastova V, Garcia A, Grimaud G, Halpern A, Harrison SA, Jordan SF,
Jia TZ, Kahana A, Kolchinsky A, Moron-Garcia O, Mizuuchi R, Nan J, Orlova Y, Pearce
BKD, Paschek K, Preiner M, Pinna S, Rodríguez-Román E, Schwander L, Sharma S,
Smith HB, Vieira A, Xavier JC. 2026. What it takes to solve the origins of life:
An integrated review. Part 2: Theoretical methods and emerging trends. Cell Reports
Physical Science. 7(4), 103211.'
mla: 'Asche, Silke, et al. “What It Takes to Solve the Origins of Life: An Integrated
Review. Part 2: Theoretical Methods and Emerging Trends.” Cell Reports Physical
Science, vol. 7, no. 4, 103211, Elsevier, 2026, doi:10.1016/j.xcrp.2026.103211.'
short: S. Asche, C. Bautista, C. Blanco, D. Boulesteix, A. Champagne-Ruel, C. Mathis,
O. Markovitch, Z. Peng, A.V. Dass, A. Adams, E. Camprubi, E.S. Colizzi, S. Colón-Santos,
H. Dromiack, V. Erastova, A. Garcia, G. Grimaud, A. Halpern, S.A. Harrison, S.F.
Jordan, T.Z. Jia, A. Kahana, A. Kolchinsky, O. Moron-Garcia, R. Mizuuchi, J. Nan,
Y. Orlova, B.K.D. Pearce, K. Paschek, M. Preiner, S. Pinna, E. Rodríguez-Román,
L. Schwander, S. Sharma, H.B. Smith, A. Vieira, J.C. Xavier, Cell Reports Physical
Science 7 (2026).
date_created: 2026-04-19T22:07:50Z
date_published: 2026-04-15T00:00:00Z
date_updated: 2026-05-07T12:13:07Z
day: '15'
ddc:
- '570'
doi: 10.1016/j.xcrp.2026.103211
file:
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checksum: d5abe5b5bd4b9ee58aa6f4917f688ad9
content_type: application/pdf
creator: dernst
date_created: 2026-05-06T06:48:33Z
date_updated: 2026-05-06T06:48:33Z
file_id: '21804'
file_name: 2026_CellReports_OoLEN.pdf
file_size: 5265320
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license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '04'
oa: 1
oa_version: Published Version
publication: Cell Reports Physical Science
publication_identifier:
eissn:
- 2666-3864
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'What it takes to solve the origins of life: An integrated review. Part 2:
Theoretical methods and emerging trends'
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21778'
abstract:
- lang: eng
text: "We prove that every \U0001D43F-bilipschitz mapping ℤ 2 → ℝ2 canbe extended
to a \U0001D436(\U0001D43F)-bilipschitz mapping ℝ2 → ℝ2,and we provide a polynomial
upper bound for \U0001D436(\U0001D43F).Moreover, we extend the result to every
separated netin ℝ2 instead of ℤ 2, with the upper bound gaininga polynomial dependence
on the separation and netconstants associated to the given separated net. Thisanswers
an Oberwolfach question of Navas from 2015and is also a positive solution of the
two-dimensionalform of a decades old open (in all dimensions at leasttwo) problem
due to Alestalo Trotsenko and Väisälä."
acknowledgement: The authors wish to thank Professor Leonid Kovalev for a valuable
observation on the first versionof this work, which led to improved estimates and
cleaner proofs in Section 6. The present workdeveloped from a research visit of
Michael Dymond to Vojtěch Kaluža at IST Austria, funded by aLondon Mathematical
Society Research in Pairs grant. This work was done whilst Vojtěch Kalužawas fully
funded by the Austria Science Fund (FWF) [M 3100-N].
article_number: e70540
article_processing_charge: Yes (in subscription journal)
article_type: original
arxiv: 1
author:
- first_name: Michael
full_name: Dymond, Michael
last_name: Dymond
- first_name: Vojtech
full_name: Kaluza, Vojtech
id: 21AE5134-9EAC-11EA-BEA2-D7BD3DDC885E
last_name: Kaluza
orcid: 0000-0002-2512-8698
citation:
ama: Dymond M, Kaluza V. Planar bilipschitz extension from separated nets. Journal
of the London Mathematical Society. 2026;113(4). doi:10.1112/jlms.70540
apa: Dymond, M., & Kaluza, V. (2026). Planar bilipschitz extension from separated
nets. Journal of the London Mathematical Society. Wiley. https://doi.org/10.1112/jlms.70540
chicago: Dymond, Michael, and Vojtech Kaluza. “Planar Bilipschitz Extension from
Separated Nets.” Journal of the London Mathematical Society. Wiley, 2026.
https://doi.org/10.1112/jlms.70540.
ieee: M. Dymond and V. Kaluza, “Planar bilipschitz extension from separated nets,”
Journal of the London Mathematical Society, vol. 113, no. 4. Wiley, 2026.
ista: Dymond M, Kaluza V. 2026. Planar bilipschitz extension from separated nets.
Journal of the London Mathematical Society. 113(4), e70540.
mla: Dymond, Michael, and Vojtech Kaluza. “Planar Bilipschitz Extension from Separated
Nets.” Journal of the London Mathematical Society, vol. 113, no. 4, e70540,
Wiley, 2026, doi:10.1112/jlms.70540.
short: M. Dymond, V. Kaluza, Journal of the London Mathematical Society 113 (2026).
date_created: 2026-05-03T22:01:37Z
date_published: 2026-04-01T00:00:00Z
date_updated: 2026-05-07T08:29:18Z
day: '01'
ddc:
- '510'
department:
- _id: UlWa
doi: 10.1112/jlms.70540
external_id:
arxiv:
- '2410.22294'
file:
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creator: dernst
date_created: 2026-05-07T08:27:43Z
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file_size: 617569
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intvolume: ' 113'
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language:
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license: https://creativecommons.org/licenses/by/4.0/
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: fc35eaa2-9c52-11eb-aca3-88501ab155e9
grant_number: M03100
name: Spectra and topology of graphs and of simplicial complexes
publication: Journal of the London Mathematical Society
publication_identifier:
eissn:
- 1469-7750
issn:
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publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Planar bilipschitz extension from separated nets
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 113
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21754'
abstract:
- lang: eng
text: The origin(s) of life (OoL), which has puzzled scientists for centuries, remains
a major scientific challenge in the 21st century. Research on OoL spans many disciplines,
including chemistry, physics, biology, planetary sciences, computer science, and
mathematics. The sheer number of different scientific perspectives relevant to
the problem has resulted in the coexistence of diverse tools, techniques, data,
and software in OoL studies. This has made communication between the disciplines
relevant to the OoL extremely difficult because the interpretation of data, analyses,
or standards of evidence varies dramatically. Here, we hope to bridge this wide
field of study by providing common ground via the consolidation of techniques
rather than positing a unifying view on how life emerges. In part 1 of this review,
we cover common experimental techniques that have been used significantly in OoL
studies in recent years, while in part 2, we review theoretical, computational,
and integrative methods. Here, we discuss the use of spectroscopy, spectrometry,
chromatography, microscopy, and sequencing methods for characterizing diverse
materials. We further discuss the role of data repositories in facilitating the
analysis and dissemination of experimental data. This review provides a baseline
expectation and understanding of the analytical aspects of origins’ research.
Ultimately, we aim to provide an educational tool that can facilitate more post-disciplinary
collaborations in OoL research by helping scientists understand what they can
do about the problem of life’s origins, rather than telling them how to think
about it.
acknowledgement: This work is a collaborative effort of the titled authors as part
of the Origin of Life Early Career Network (OoLEN). We chose to add OoLEN as the
first author to give a better representation of this team effort, rather than listing
any single author as the first author. We hope such a thing can be adopted by others.
We indicate that authors 2–9 (S.A., C.B., C. Blanco, D.B., A.C.-R., C.M., O.M.,
Z.P., and A.V.D.) have made a more distinct contribution. All authors are listed
alphabetically by their last names. We would like to acknowledge all current and
past members of OoLEN for their contributions to our community. In particular, we
would like to acknowledge Evrim Fer, who helped with molecular phylogenetics. We
would like to thank the anonymous referees for reviewing Parts 1 and 2 of this manuscript;
this work was significantly improved through their feedback. S.A. acknowledges support
from NASA through the postdoctoral Program at GSFC. C. Bautista acknowledges support
from “la Caixa” Foundation (ID 100010434) under agreement (LCF/BQ/AA16/11580051)
and by the Fonds de recherche du Québec Nature et technologies (FRQNT) (#274987).
C. Blanco acknowledges support from NASA under award 80NSSC21K0595. D.B. acknowledges
support from Centre national d'études spatiales (CNES) and postdoctoral support
from LGPM-CentralSupélec and NASA under award 80NSSC23K1477. E. Camprubi acknowledges
support from UT System for a STARs award. A.C.-R. acknowledges funding from the
Natural Sciences and Engineering Research Council of Canada (grant number RGPIN/05278–2018),
the Fonds de recherche Nature et Technologies of Québec (grant number 314488), and
the Fondation J. Armand Bombardier Excellence Scholarship. A.C.-R.’s research was
supported by an appointment to the NASA Postdoctoral Program from the NASA Astrobiology
Program administered by Oak Ridge Associated Universities under contract with NASA.
S.F.J. acknowledges support from “la Caixa” Foundation (ID 100010434) and from the
European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska
Curie grant agreement no. 847648 (the fellowship code is LCF/BQ/PI21/11830015).
T.Z.J. acknowledges support from Japan Society for the Promotion of Science (JSPS)
grants-in-aid 18K14354 and 21K14746, a Tokyo Institute of Technology Yoshinori Ohsumi
Fund for Fundamental Research, the Mizuho Foundation for the Promotion of Sciences,
and by the Temporary Assistant Program by the DE&I Section of Science Tokyo. A.K.
acknowledges support from the European Union’s Horizon 2020 research and innovation
program under the Marie Skłodowska-Curie Grant agreement no. 101068029. C.M. acknowledges
support from NASA through the postdoctoral Fellowship Program. The views and conclusions
contained in this document are those of the authors and should not be interpreted
as representing the official policies, either expressed or implied, of NASA. O.M.
acknowledges support from The John Templeton Foundation (#62828) and the Foundation
for Science and Technology (2023.05971.CEECIND). B.K.D.P. acknowledges support from
the NSERC Banting Postdoctoral Fellowship. K.P. acknowledges financial support from
the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s
Excellence Strategy EXC 2181/1 - 390900948 (the Heidelberg STRUCTURES Excellence
Cluster) and is a fellow of the International Max Planck Research School for Astronomy
and Cosmic Physics at the University of Heidelberg (IMPRS-HD).
article_number: '103212'
article_processing_charge: Yes
article_type: original
author:
- first_name: Silke
full_name: Asche, Silke
last_name: Asche
- first_name: Carla
full_name: Bautista, Carla
last_name: Bautista
- first_name: Celia
full_name: Blanco, Celia
last_name: Blanco
- first_name: David
full_name: Boulesteix, David
last_name: Boulesteix
- first_name: Alexandre
full_name: Champagne-Ruel, Alexandre
last_name: Champagne-Ruel
- first_name: Cole
full_name: Mathis, Cole
last_name: Mathis
- first_name: Omer
full_name: Markovitch, Omer
last_name: Markovitch
- first_name: Zhen
full_name: Peng, Zhen
last_name: Peng
- first_name: Avinash Vicholous
full_name: Dass, Avinash Vicholous
last_name: Dass
- first_name: Alyssa
full_name: Adams, Alyssa
last_name: Adams
- first_name: Eloi
full_name: Camprubi, Eloi
last_name: Camprubi
- first_name: Enrico Sandro
full_name: Colizzi, Enrico Sandro
last_name: Colizzi
- first_name: Stephanie
full_name: Colón-Santos, Stephanie
last_name: Colón-Santos
- first_name: Hannah
full_name: Dromiack, Hannah
last_name: Dromiack
- first_name: Valentina
full_name: Erastova, Valentina
last_name: Erastova
- first_name: Amanda
full_name: Garcia, Amanda
last_name: Garcia
- first_name: Ghjuvan
full_name: Grimaud, Ghjuvan
last_name: Grimaud
- first_name: Aaron
full_name: Halpern, Aaron
last_name: Halpern
- first_name: Stuart A.
full_name: Harrison, Stuart A.
last_name: Harrison
- first_name: Seán F.
full_name: Jordan, Seán F.
last_name: Jordan
- first_name: Tony Z.
full_name: Jia, Tony Z.
last_name: Jia
- first_name: Amit
full_name: Kahana, Amit
last_name: Kahana
- first_name: Artemy
full_name: Kolchinsky, Artemy
last_name: Kolchinsky
- first_name: Odin
full_name: Moron-Garcia, Odin
last_name: Moron-Garcia
- first_name: Ryo
full_name: Mizuuchi, Ryo
last_name: Mizuuchi
- first_name: Jingbo
full_name: Nan, Jingbo
last_name: 'Nan'
- first_name: Yuliia
full_name: Orlova, Yuliia
last_name: Orlova
- first_name: Ben K.D.
full_name: Pearce, Ben K.D.
last_name: Pearce
- first_name: Klaus
full_name: Paschek, Klaus
last_name: Paschek
- first_name: Martina
full_name: Preiner, Martina
last_name: Preiner
- first_name: Silvana
full_name: Pinna, Silvana
last_name: Pinna
- first_name: Eduardo
full_name: Rodríguez-Román, Eduardo
last_name: Rodríguez-Román
- first_name: Loraine
full_name: Schwander, Loraine
last_name: Schwander
- first_name: Siddhant
full_name: Sharma, Siddhant
id: 36996868-4916-11f1-8c9d-c0c901467b61
last_name: Sharma
- first_name: Harrison B.
full_name: Smith, Harrison B.
last_name: Smith
- first_name: Andrey
full_name: Vieira, Andrey
last_name: Vieira
- first_name: Joana C.
full_name: Xavier, Joana C.
last_name: Xavier
citation:
ama: 'Asche S, Bautista C, Blanco C, et al. What it takes to solve the origin of
life: An integrated review. Part 1–Experimental methods and data repositories.
Cell Reports Physical Science. 2026;7(4). doi:10.1016/j.xcrp.2026.103212'
apa: 'Asche, S., Bautista, C., Blanco, C., Boulesteix, D., Champagne-Ruel, A., Mathis,
C., … Xavier, J. C. (2026). What it takes to solve the origin of life: An integrated
review. Part 1–Experimental methods and data repositories. Cell Reports Physical
Science. Elsevier. https://doi.org/10.1016/j.xcrp.2026.103212'
chicago: 'Asche, Silke, Carla Bautista, Celia Blanco, David Boulesteix, Alexandre
Champagne-Ruel, Cole Mathis, Omer Markovitch, et al. “What It Takes to Solve the
Origin of Life: An Integrated Review. Part 1–Experimental Methods and Data Repositories.”
Cell Reports Physical Science. Elsevier, 2026. https://doi.org/10.1016/j.xcrp.2026.103212.'
ieee: 'S. Asche et al., “What it takes to solve the origin of life: An integrated
review. Part 1–Experimental methods and data repositories,” Cell Reports Physical
Science, vol. 7, no. 4. Elsevier, 2026.'
ista: 'Asche S, Bautista C, Blanco C, Boulesteix D, Champagne-Ruel A, Mathis C,
Markovitch O, Peng Z, Dass AV, Adams A, Camprubi E, Colizzi ES, Colón-Santos S,
Dromiack H, Erastova V, Garcia A, Grimaud G, Halpern A, Harrison SA, Jordan SF,
Jia TZ, Kahana A, Kolchinsky A, Moron-Garcia O, Mizuuchi R, Nan J, Orlova Y, Pearce
BKD, Paschek K, Preiner M, Pinna S, Rodríguez-Román E, Schwander L, Sharma S,
Smith HB, Vieira A, Xavier JC. 2026. What it takes to solve the origin of life:
An integrated review. Part 1–Experimental methods and data repositories. Cell
Reports Physical Science. 7(4), 103212.'
mla: 'Asche, Silke, et al. “What It Takes to Solve the Origin of Life: An Integrated
Review. Part 1–Experimental Methods and Data Repositories.” Cell Reports Physical
Science, vol. 7, no. 4, 103212, Elsevier, 2026, doi:10.1016/j.xcrp.2026.103212.'
short: S. Asche, C. Bautista, C. Blanco, D. Boulesteix, A. Champagne-Ruel, C. Mathis,
O. Markovitch, Z. Peng, A.V. Dass, A. Adams, E. Camprubi, E.S. Colizzi, S. Colón-Santos,
H. Dromiack, V. Erastova, A. Garcia, G. Grimaud, A. Halpern, S.A. Harrison, S.F.
Jordan, T.Z. Jia, A. Kahana, A. Kolchinsky, O. Moron-Garcia, R. Mizuuchi, J. Nan,
Y. Orlova, B.K.D. Pearce, K. Paschek, M. Preiner, S. Pinna, E. Rodríguez-Román,
L. Schwander, S. Sharma, H.B. Smith, A. Vieira, J.C. Xavier, Cell Reports Physical
Science 7 (2026).
date_created: 2026-04-19T22:07:52Z
date_published: 2026-04-15T00:00:00Z
date_updated: 2026-05-07T12:13:25Z
day: '15'
ddc:
- '570'
doi: 10.1016/j.xcrp.2026.103212
file:
- access_level: open_access
checksum: e580d22c2874c0afcbde2d167db7201b
content_type: application/pdf
creator: dernst
date_created: 2026-05-07T05:48:23Z
date_updated: 2026-05-07T05:48:23Z
file_id: '21831'
file_name: 2026_CellREports_OoLEN1.pdf
file_size: 3535247
relation: main_file
success: 1
file_date_updated: 2026-05-07T05:48:23Z
has_accepted_license: '1'
intvolume: ' 7'
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
publication: Cell Reports Physical Science
publication_identifier:
eissn:
- 2666-3864
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'What it takes to solve the origin of life: An integrated review. Part 1–Experimental
methods and data repositories'
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21846'
abstract:
- lang: eng
text: 'We compile a sample of 83 little red dots (LRDs) with JWST imaging and find
that a substantial fraction (∼43%, rising to ≳80% for the most luminous LRDs)
host one or more spatially offset, UV-bright companions at projected separations
of 0.5 kpc ≲ d ≲ 5 kpc, with median 〈d〉 = 1.0 kpc. This fraction is even higher
when smaller spatial scales are probed at high signal-to-noise ratio: the two
most strongly lensed LRDs, A383-LRD1 and the newly discovered A68-LRD1, both have
UV-bright companions at separations of only d ∼ 0.3 kpc, below the resolution
limit of most unlensed JWST samples. We explore whether these ubiquitous red/blue
configurations may be physically linked to the formation of LRDs, in analogy with
the “synchronized pair” scenario originally proposed for direct-collapse black
hole formation. In this picture, UV radiation from the companions, with typically
modest stellar masses (M∗ ∼ 108−109 M⊙), suppresses molecular hydrogen cooling
in nearby gas, allowing nearly isothermal collapse and the formation of extremely
compact objects, such as massive black holes, supermassive stars, or quasi-stars.
Using component-resolved photometry and spectral energy distribution modeling,
we infer Lyman–Werner radiation fields of J21,LW ∼ 102.5–105 at the locations
of the red components, comparable to those required in direct-collapse models,
suggesting that the necessary photodissociation conditions are realized in many
LRD systems. This framework provides a simple and self-consistent explanation
for the extreme compactness and distinctive spectral properties of LRDs and links
long-standing theoretical models for early compact object formation directly to
a population now observed with JWST in the early Universe.'
acknowledgement: 'We thank Earl Bellinger, Fabio Pacucci, Andrea Ferrara, and Dale
Kocevski for useful discussions. This work is based on observations made with the
NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski
Archive for Space Telescopes at the Space Telescope Science Institute, which is
operated by the Association of Universities for Research in Astronomy, Inc., under
NASA contract NAS 5-03127 for JWST. These imaging observations are associated with
programs 1345, 1180, 1181, 1243, 6882, 2561, 1324, 4111, and 1895. The compiled
dataset can be accessed at doi:10.17909/1m8f-9c47. The Cosmic Dawn Center (DAWN)
is funded by the Danish National Research Foundation under grant DNRF140. J.M. and
A.T. acknowledge funding by the European Union (ERC, AGENTS, 101076224). This work
was performed in part at Aspen Center for Physics, which is supported by National
Science Foundation grant PHY-2210452. This work used the following Python packages:
Matplotlib (J. D. Hunter 2007), SciPy (P. Virtanen et al. 2020), NumPy (S. van der
Walt et al. 2011), AstroPy (Astropy Collaboration et al. 2022), colossus (B. Diemer
2018), and photutils (L. Bradley et al. 2025).'
article_number: L4
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Josephine F.W.
full_name: Baggen, Josephine F.W.
last_name: Baggen
- first_name: Matthew T.
full_name: Scoggins, Matthew T.
last_name: Scoggins
- first_name: Pieter
full_name: Van Dokkum, Pieter
last_name: Van Dokkum
- first_name: Zoltán
full_name: Haiman, Zoltán
id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
last_name: Haiman
orcid: 0000-0003-3633-5403
- first_name: Alberto
full_name: Torralba Torregrosa, Alberto
id: 018f0249-0e87-11f0-b167-cbce08fbd541
last_name: Torralba Torregrosa
orcid: 0000-0001-5586-6950
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
citation:
ama: 'Baggen JFW, Scoggins MT, Van Dokkum P, Haiman Z, Torralba Torregrosa A, Matthee
JJ. Connecting the dots: UV-bright companions of Little Red Dots as Lyman–Werner
sources enabling direct-collapse Black Hole formation. The Astrophysical Journal
Letters. 2026;1002(1). doi:10.3847/2041-8213/ae58a5'
apa: 'Baggen, J. F. W., Scoggins, M. T., Van Dokkum, P., Haiman, Z., Torralba Torregrosa,
A., & Matthee, J. J. (2026). Connecting the dots: UV-bright companions of
Little Red Dots as Lyman–Werner sources enabling direct-collapse Black Hole formation.
The Astrophysical Journal Letters. IOP Publishing. https://doi.org/10.3847/2041-8213/ae58a5'
chicago: 'Baggen, Josephine F.W., Matthew T. Scoggins, Pieter Van Dokkum, Zoltán
Haiman, Alberto Torralba Torregrosa, and Jorryt J Matthee. “Connecting the Dots:
UV-Bright Companions of Little Red Dots as Lyman–Werner Sources Enabling Direct-Collapse
Black Hole Formation.” The Astrophysical Journal Letters. IOP Publishing,
2026. https://doi.org/10.3847/2041-8213/ae58a5.'
ieee: 'J. F. W. Baggen, M. T. Scoggins, P. Van Dokkum, Z. Haiman, A. Torralba Torregrosa,
and J. J. Matthee, “Connecting the dots: UV-bright companions of Little Red Dots
as Lyman–Werner sources enabling direct-collapse Black Hole formation,” The
Astrophysical Journal Letters, vol. 1002, no. 1. IOP Publishing, 2026.'
ista: 'Baggen JFW, Scoggins MT, Van Dokkum P, Haiman Z, Torralba Torregrosa A, Matthee
JJ. 2026. Connecting the dots: UV-bright companions of Little Red Dots as Lyman–Werner
sources enabling direct-collapse Black Hole formation. The Astrophysical Journal
Letters. 1002(1), L4.'
mla: 'Baggen, Josephine F. W., et al. “Connecting the Dots: UV-Bright Companions
of Little Red Dots as Lyman–Werner Sources Enabling Direct-Collapse Black Hole
Formation.” The Astrophysical Journal Letters, vol. 1002, no. 1, L4, IOP
Publishing, 2026, doi:10.3847/2041-8213/ae58a5.'
short: J.F.W. Baggen, M.T. Scoggins, P. Van Dokkum, Z. Haiman, A. Torralba Torregrosa,
J.J. Matthee, The Astrophysical Journal Letters 1002 (2026).
date_created: 2026-05-10T22:02:15Z
date_published: 2026-04-10T00:00:00Z
date_updated: 2026-05-11T06:48:33Z
day: '10'
ddc:
- '520'
department:
- _id: ZoHa
- _id: JoMa
doi: 10.3847/2041-8213/ae58a5
external_id:
arxiv:
- '2602.02702'
file:
- access_level: open_access
checksum: 8c31d8603cd6ad39c772a72d136dc3f8
content_type: application/pdf
creator: dernst
date_created: 2026-05-11T06:44:37Z
date_updated: 2026-05-11T06:44:37Z
file_id: '21851'
file_name: 2026_AstrophysicalJourLetters_Baggen.pdf
file_size: 13359642
relation: main_file
success: 1
file_date_updated: 2026-05-11T06:44:37Z
has_accepted_license: '1'
intvolume: ' 1002'
issue: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: bd9b2118-d553-11ed-ba76-db24564edfea
grant_number: '101076224'
name: Young galaxies as tracers and agents of cosmic reionization
publication: The Astrophysical Journal Letters
publication_identifier:
eissn:
- 2041-8213
issn:
- 2041-8205
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Connecting the dots: UV-bright companions of Little Red Dots as Lyman–Werner
sources enabling direct-collapse Black Hole formation'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1002
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21845'
abstract:
- lang: eng
text: UTe2 exhibits the remarkable phenomenon of re-entrant superconductivity, whereby
the zero-resistance state reappears above 40 tesla after being suppressed with
a field of around 10 tesla. One potential pairing mechanism, invoked in the related
re-entrant superconductors UCoGe and URhGe, involves transverse fluctuations of
a ferromagnetic order parameter. However, the requisite ferromagnetic order—present
in both UCoGe and URhGe—is absent in UTe2, and neutron scattering shows instead
that the magnetic susceptibility is peaked at an antiferromagnetic wavevector.
Here, we measure the magnetotropic susceptibility of UTe2 across two field-angle
planes. This quantity is sensitive to the magnetic susceptibility in a direction
transverse to the applied magnetic field—a quantity that is not accessed in conventional
magnetization measurements. We observe a very large decrease in the magnetotropic
susceptibility over a broad range of field orientations, indicating a large increase
in the transverse magnetic susceptibility. Because our technique probes the magnetic
susceptibility in the long wavelength (q = 0) limit, this suggests that the strong
transverse susceptibility arises from ferromagnetic spin fluctuations. These ferromagnetic
fluctuations are likely important for understanding the pairing mechanism in UTe2,
as all three superconducting phases of UTe2 surround this region of enhanced susceptibility
in the field-angle phase diagram.
acknowledged_ssus:
- _id: NanoFab
acknowledgement: We appreciate technical support from Salvatore Bagiante, Evgeniia
Volobueva, Lubuna Shafeek, Ali Bangura, and Zoltán Köllö, and scientific discussions
with Daniel Agterberg, Johnpierre Paglione, Qimiao Si, Josephine Yu and Yue Yu.
V.Z., A.N., M.N., and K.A.M. acknowledge funding received from the European Research
Council (ERC) under the European Union’s Horizon 2020 research and innovation programme
(TROPIC-101078696). V.Z., A.N., M.N., and K.A.M. thank the ISTA Nanofabrication
Facility for technical support. B.J.R. acknowledges funding from the Office of Basic
Energy Sciences of the United States Department of Energy under award number DE-SC0020143
for data analysis and writing. The National High Magnetic Field Laboratory is supported
by the National Science Foundation through NSF/DMR-2128556*, the State of Florida,
and the U.S. Department of Energy. A.S. acknowledges support from the DOE/BES “Science
of 100 T” grant. A.S. thanks Downtown Subscription in Santa Fe, NM, for their patience
in hosting him. Sample preparation and characterization were supported by the NSF
through DMR-2105191.
article_number: '3742'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Valeska
full_name: Zambra, Valeska
id: 467ed36b-dc96-11ea-b7c8-b043a380b282
last_name: Zambra
orcid: 0000-0002-8806-5719
- first_name: Amit
full_name: Nathwani, Amit
id: 1a362536-4d02-11f1-8543-8351136efc50
last_name: Nathwani
- first_name: Muhammad
full_name: Nauman, Muhammad
id: 32c21954-2022-11eb-9d5f-af9f93c24e71
last_name: Nauman
orcid: 0000-0002-2111-4846
- first_name: Sylvia K.
full_name: Lewin, Sylvia K.
last_name: Lewin
- first_name: Corey E.
full_name: Frank, Corey E.
last_name: Frank
- first_name: Nicholas P.
full_name: Butch, Nicholas P.
last_name: Butch
- first_name: Arkady
full_name: Shekhter, Arkady
last_name: Shekhter
- first_name: B. J.
full_name: Ramshaw, B. J.
last_name: Ramshaw
- first_name: Kimberly A
full_name: Modic, Kimberly A
id: 13C26AC0-EB69-11E9-87C6-5F3BE6697425
last_name: Modic
orcid: 0000-0001-9760-3147
citation:
ama: Zambra V, Nathwani A, Nauman M, et al. Giant transverse magnetic fluctuations
at the edge of re-entrant superconductivity in UTe2. Nature Communications.
2026;17. doi:10.1038/s41467-026-71899-7
apa: Zambra, V., Nathwani, A., Nauman, M., Lewin, S. K., Frank, C. E., Butch, N.
P., … Modic, K. A. (2026). Giant transverse magnetic fluctuations at the edge
of re-entrant superconductivity in UTe2. Nature Communications. Springer
Nature. https://doi.org/10.1038/s41467-026-71899-7
chicago: Zambra, Valeska, Amit Nathwani, Muhammad Nauman, Sylvia K. Lewin, Corey
E. Frank, Nicholas P. Butch, Arkady Shekhter, B. J. Ramshaw, and Kimberly A Modic.
“Giant Transverse Magnetic Fluctuations at the Edge of Re-Entrant Superconductivity
in UTe2.” Nature Communications. Springer Nature, 2026. https://doi.org/10.1038/s41467-026-71899-7.
ieee: V. Zambra et al., “Giant transverse magnetic fluctuations at the edge
of re-entrant superconductivity in UTe2,” Nature Communications, vol. 17.
Springer Nature, 2026.
ista: Zambra V, Nathwani A, Nauman M, Lewin SK, Frank CE, Butch NP, Shekhter A,
Ramshaw BJ, Modic KA. 2026. Giant transverse magnetic fluctuations at the edge
of re-entrant superconductivity in UTe2. Nature Communications. 17, 3742.
mla: Zambra, Valeska, et al. “Giant Transverse Magnetic Fluctuations at the Edge
of Re-Entrant Superconductivity in UTe2.” Nature Communications, vol. 17,
3742, Springer Nature, 2026, doi:10.1038/s41467-026-71899-7.
short: V. Zambra, A. Nathwani, M. Nauman, S.K. Lewin, C.E. Frank, N.P. Butch, A.
Shekhter, B.J. Ramshaw, K.A. Modic, Nature Communications 17 (2026).
corr_author: '1'
date_created: 2026-05-10T22:02:15Z
date_published: 2026-04-29T00:00:00Z
date_updated: 2026-05-11T06:36:00Z
day: '29'
ddc:
- '530'
department:
- _id: KiMo
- _id: GradSch
doi: 10.1038/s41467-026-71899-7
external_id:
arxiv:
- '2506.08984'
file:
- access_level: open_access
checksum: 8cb95b033ad2a1a7a8181f6f078c05b5
content_type: application/pdf
creator: dernst
date_created: 2026-05-11T06:32:12Z
date_updated: 2026-05-11T06:32:12Z
file_id: '21850'
file_name: 2026_NatureComm_Zambra.pdf
file_size: 1784917
relation: main_file
success: 1
file_date_updated: 2026-05-11T06:32:12Z
has_accepted_license: '1'
intvolume: ' 17'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: bd968c70-d553-11ed-ba76-cde40b0aba64
grant_number: '101078696'
name: Gaining leverage with spin liquids and superconductors
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '21174'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Giant transverse magnetic fluctuations at the edge of re-entrant superconductivity
in UTe2
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21847'
abstract:
- lang: eng
text: Analog quantum simulators provide access to many-body dynamics beyond the
reach of classical computation. However, extracting physical insights from experimental
data is often hindered by measurement noise, limited observables, and incomplete
knowledge of the underlying microscopic model. Here, we develop a machine learning
approach based on a variational autoencoder (VAE) to analyze interference measurements
of tunnel-coupled one-dimensional Bose gases, which realize the sine-Gordon quantum
field theory. Trained in an unsupervised manner, the VAE learns a minimal latent
representation that strongly correlates with the equilibrium control parameter
of the system. Applied to nonequilibrium protocols, the latent space uncovers
signatures of frozen-in solitons following rapid cooling, and reveals anomalous
postquench dynamics not captured by conventional correlation-based methods. These
results demonstrate that generative models can extract physically interpretable
variables directly from noisy and sparse experimental data, providing complementary
probes of equilibrium and nonequilibrium physics in quantum simulators. More broadly,
our work highlights how machine learning can supplement established field-theoretical
techniques, paving the way for scalable, data-driven discovery in quantum many-body
systems.
acknowledgement: "We thank Sebastian Erne and Igor Mazets for helpful discussions
and sharing codes for the transfer matrix sampling. This research was funded in
part by the European Research Council: ERC Advanced Grant “Emergence in Quantum
Physics” (EmQ) under Grant Agreement No. 101097858 and ERC Advanced Grant “Artificial
agency and learning in quantum environments” (QuantAI) under Grant Agreement No.
101055129. This work was also supported by the Austrian Science Fund (FWF) (SFB
BeyondC F7102, 10.55776/F71). G.F.-F. acknowledges the European Research Council
AdG NOQIA; MCIN/AEI [PGC2018-0910.13039/501100011033, CEX2019-000910-S/10.13039/501100011033,
Plan National FIDEUA PID2019-106901GB-I00, Plan National STAMEENA PID2022-139099NB,
I00, project funded by MCIN/AEI/10.13039/501100011033 and by the “European Union
NextGenerationEU/PRTR” (PRTR-C17.I1), FPI]; QUANTERA DYNAMITE PCI2022-132919 under
Grant Agreement No. 101017733; Ministry for Digital Transformation and of Civil
Service of the Spanish Government through the QUANTUM ENIA project call—Quantum
Spain project, and by the European Union through the Recovery, Transformation and
Resilience Plan—NextGenerationEU within the framework of the Digital Spain 2026
Agenda; Fundació Cellex; Fundació Mir-Puig; Generalitat de Catalunya (European Social
Fund FEDER and CERCA program); Barcelona Supercomputing Center MareNostrum (FI-2023-3-0024);
(HORIZON-CL4-2022-QUANTUM-02-SGA PASQuanS2.1, 101113690, EU Horizon 2020 FET-OPEN
OPTOlogic, Grant No. 899794, QU-ATTO, 101168628), EU Horizon Europe Program (This
project has received funding from the European Union's Horizon Europe research and
innovation program under Grant Agreement No. 101080086 NeQST); ICFO Internal “QuantumGaudi”
project. This research was funded in whole or in part by the Austrian Science Fund
(FWF) [10.55776/COE1] through the Cluster of Excellence quantA (Quantum Science
Austria).\r\n\r\nThe views and opinions expressed in this article are however those
of the author(s) only and do not necessarily reflect those of the European Union
or the European Research Council—neither the European Union nor the granting authority
can be held responsible for them."
article_number: '023094'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Frederik Skovbo
full_name: Moller, Frederik Skovbo
id: 43cbcc83-0564-11f0-a935-e37325525859
last_name: Moller
- first_name: Gabriel
full_name: Fernández-Fernández, Gabriel
last_name: Fernández-Fernández
- first_name: Thomas
full_name: Schweigler, Thomas
last_name: Schweigler
- first_name: Paulin
full_name: De Schoulepnikoff, Paulin
last_name: De Schoulepnikoff
- first_name: Jörg
full_name: Schmiedmayer, Jörg
last_name: Schmiedmayer
- first_name: Gorka
full_name: Muñoz-Gil, Gorka
last_name: Muñoz-Gil
citation:
ama: Moller FS, Fernández-Fernández G, Schweigler T, De Schoulepnikoff P, Schmiedmayer
J, Muñoz-Gil G. Learning minimal representations of many-body physics from snapshots
of a quantum simulator. Physical Review Research. 2026;8(2). doi:10.1103/r7pj-gl7r
apa: Moller, F. S., Fernández-Fernández, G., Schweigler, T., De Schoulepnikoff,
P., Schmiedmayer, J., & Muñoz-Gil, G. (2026). Learning minimal representations
of many-body physics from snapshots of a quantum simulator. Physical Review
Research. American Physical Society. https://doi.org/10.1103/r7pj-gl7r
chicago: Moller, Frederik Skovbo, Gabriel Fernández-Fernández, Thomas Schweigler,
Paulin De Schoulepnikoff, Jörg Schmiedmayer, and Gorka Muñoz-Gil. “Learning Minimal
Representations of Many-Body Physics from Snapshots of a Quantum Simulator.” Physical
Review Research. American Physical Society, 2026. https://doi.org/10.1103/r7pj-gl7r.
ieee: F. S. Moller, G. Fernández-Fernández, T. Schweigler, P. De Schoulepnikoff,
J. Schmiedmayer, and G. Muñoz-Gil, “Learning minimal representations of many-body
physics from snapshots of a quantum simulator,” Physical Review Research,
vol. 8, no. 2. American Physical Society, 2026.
ista: Moller FS, Fernández-Fernández G, Schweigler T, De Schoulepnikoff P, Schmiedmayer
J, Muñoz-Gil G. 2026. Learning minimal representations of many-body physics from
snapshots of a quantum simulator. Physical Review Research. 8(2), 023094.
mla: Moller, Frederik Skovbo, et al. “Learning Minimal Representations of Many-Body
Physics from Snapshots of a Quantum Simulator.” Physical Review Research,
vol. 8, no. 2, 023094, American Physical Society, 2026, doi:10.1103/r7pj-gl7r.
short: F.S. Moller, G. Fernández-Fernández, T. Schweigler, P. De Schoulepnikoff,
J. Schmiedmayer, G. Muñoz-Gil, Physical Review Research 8 (2026).
date_created: 2026-05-10T22:02:15Z
date_published: 2026-04-29T00:00:00Z
date_updated: 2026-05-11T06:58:56Z
day: '29'
ddc:
- '530'
department:
- _id: EdHa
doi: 10.1103/r7pj-gl7r
external_id:
arxiv:
- '2509.13821'
file:
- access_level: open_access
checksum: dbfc58e1e176f7b63e0d274eb0d1bffa
content_type: application/pdf
creator: dernst
date_created: 2026-05-11T06:56:58Z
date_updated: 2026-05-11T06:56:58Z
file_id: '21852'
file_name: 2026_PhysicalReviewResearch_Moller.pdf
file_size: 1829628
relation: main_file
success: 1
file_date_updated: 2026-05-11T06:56:58Z
has_accepted_license: '1'
intvolume: ' 8'
issue: '2'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
publication: Physical Review Research
publication_identifier:
eissn:
- 2643-1564
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Learning minimal representations of many-body physics from snapshots of a quantum
simulator
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2026'
...
---
OA_place: repository
OA_type: free access
_id: '21174'
abstract:
- lang: eng
text: UTe2 exhibits the remarkable phenomenon of re-entrant superconductivity, whereby
the zero-resistance state reappears above 40 tesla after being suppressed with
a field of around 10 tesla. One potential pairing mechanism, invoked in the related
re-entrant superconductors UCoGe and URhGe, involves transverse fluctuations of
a ferromagnetic order parameter. However, the requisite ferromagnetic order -
present in both UCoGe and URhGe - is absent in UTe2, and magnetization measurements
show no sign of strong fluctuations. Here, we measure the magnetotropic susceptibility
of UTe2 across two field-angle planes. This quantity is sensitive to the magnetic
susceptibility in a direction transverse to the applied magnetic field - a quantity
that is not accessed in conventional magnetization measurements. We observe a
very large decrease in the magnetotropic susceptibility over a broad range of
field orientations, indicating a large increase in the transverse magnetic susceptibility.
The three superconducting phases of UTe2, including the high-field re-entrant
phase, surround this region of enhanced susceptibility in the field-angle phase
diagram. The strongest transverse susceptibility is found near the critical end
point of the high-field metamagnetic transition, suggesting that quantum critical
fluctuations of a field-induced magnetic order parameter may be responsible for
the large transverse susceptibility, and may provide a pairing mechanism for field-induced
superconductivity in UTe2.
acknowledged_ssus:
- _id: NanoFab
acknowledgement: Thanks to Salvatore Bagiante, Evgeniia Volobueva, Lubuna Shafeek,
Ali Bangura and Zoltan Kollo.
article_processing_charge: Yes
author:
- first_name: Kimberly A
full_name: Modic, Kimberly A
id: 13C26AC0-EB69-11E9-87C6-5F3BE6697425
last_name: Modic
orcid: 0000-0001-9760-3147
citation:
ama: Modic KA. Research data for “Giant transverse magnetic fluctuations at the
edge of re-entrant superconductivity in UTe2.” 2026. doi:10.15479/AT-ISTA-21174
apa: Modic, K. A. (2026). Research data for “Giant transverse magnetic fluctuations
at the edge of re-entrant superconductivity in UTe2.” Institute of Science and
Technology Austria. https://doi.org/10.15479/AT-ISTA-21174
chicago: Modic, Kimberly A. “Research Data for ‘Giant Transverse Magnetic Fluctuations
at the Edge of Re-Entrant Superconductivity in UTe2.’” Institute of Science and
Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21174.
ieee: K. A. Modic, “Research data for ‘Giant transverse magnetic fluctuations at
the edge of re-entrant superconductivity in UTe2.’” Institute of Science and Technology
Austria, 2026.
ista: Modic KA. 2026. Research data for ‘Giant transverse magnetic fluctuations
at the edge of re-entrant superconductivity in UTe2’, Institute of Science and
Technology Austria, 10.15479/AT-ISTA-21174.
mla: Modic, Kimberly A. Research Data for “Giant Transverse Magnetic Fluctuations
at the Edge of Re-Entrant Superconductivity in UTe2.” Institute of Science
and Technology Austria, 2026, doi:10.15479/AT-ISTA-21174.
short: K.A. Modic, (2026).
contributor:
- contributor_type: project_member
first_name: Valeska
id: 467ed36b-dc96-11ea-b7c8-b043a380b282
last_name: Zambra
orcid: 0000-0002-8806-5719
corr_author: '1'
date_created: 2026-02-09T12:04:20Z
date_published: 2026-02-19T00:00:00Z
date_updated: 2026-05-11T06:35:59Z
day: '19'
ddc:
- '530'
department:
- _id: KiMo
doi: 10.15479/AT-ISTA-21174
file:
- access_level: open_access
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content_type: text/plain
creator: kmodic
date_created: 2026-02-19T07:38:15Z
date_updated: 2026-02-19T07:38:15Z
file_id: '21332'
file_name: README.txt
file_size: 1347
relation: main_file
success: 1
- access_level: open_access
checksum: b2c8ca5620ee9c181a42082068d3d73c
content_type: application/zip
creator: kmodic
date_created: 2026-02-19T07:39:03Z
date_updated: 2026-02-19T07:39:03Z
file_id: '21333'
file_name: processed_data_bc_plane_Fig2d.zip
file_size: 534853
relation: main_file
success: 1
- access_level: open_access
checksum: 976bf113da4b1133313f0b292e71289f
content_type: application/zip
creator: kmodic
date_created: 2026-02-19T07:39:07Z
date_updated: 2026-02-19T07:39:07Z
file_id: '21334'
file_name: processed_data_ac_plane_Fig2c.zip
file_size: 427144
relation: main_file
success: 1
file_date_updated: 2026-02-19T07:39:07Z
has_accepted_license: '1'
keyword:
- transverse magnetic susceptibility
- magnetotropic
- superconductivity
- magnetic fluctuations
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: bd968c70-d553-11ed-ba76-cde40b0aba64
grant_number: '101078696'
name: Gaining leverage with spin liquids and superconductors
publisher: Institute of Science and Technology Austria
related_material:
link:
- relation: preprint
url: https://arxiv.org/pdf/2506.08984
record:
- id: '21845'
relation: used_in_publication
status: public
status: public
title: Research data for "Giant transverse magnetic fluctuations at the edge of re-entrant
superconductivity in UTe2"
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data
user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21849'
abstract:
- lang: eng
text: The development of complex tissues relies on the precise assignment of cell
identity. At the molecular scale, this process depends on the deposition of epigenetic
modifications—such as methylation—that are regulated by complex biochemical networks
and occur at specific regions on the DNA and chromatin. Here we show that despite
the complexity of epigenetic regulation, dynamical scaling and self-similarity
of DNA methylation marks emerge in embryonic development. Drawing on single-cell
multi-omics experiments, super-resolution microscopy and statistical physics,
we demonstrate that these phenomena originate in dynamical feedback between DNA
methylation and the formation of nanoscale dynamic chromatin aggregates. These
nanoscale processes lead to genome-wide increase in DNA methylation marks following
a power law and self-similar correlation functions. Using this framework, we identify
methylation patterns that precede gene expression changes in embryonic symmetry
breaking. Our work identifies linear sequencing measurements as a laboratory to
study mesoscopic biophysical processes in vivo.
acknowledgement: We thank all members of the W.R. and S.R. laboratories, F. Piazza,
B. D. Simons, and F. Jülicher for helpful discussions. We thank M. Ciarchi for providing
annotations for the chromatin compartments. S.R. is a member of the Center for Nano
Science (CeNS). This project has received funding from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme
(grant agreement number 950349). Research in W.R.’s laboratory was supported by
the Biotechnology and Biological Sciences Research Council (BB/K010867/1), Wellcome
(095645/Z/11/Z) and the European Research Council (ERC) under the European Union’s
Horizon 2020 research and innovation programme (EpiCell lineage 882798). F.O. received
funding from the European Union’s Horizon 2020 research and innovation programme
under the Marie Skłodowska-Curie grant agreement number 101034413. Open access funding
provided by Max Planck Society.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Fabrizio
full_name: Olmeda, Fabrizio
id: 69dbf5fb-8a76-11ed-866b-fb486d8b5689
last_name: Olmeda
- first_name: Tim
full_name: Lohoff, Tim
last_name: Lohoff
- first_name: Ioannis
full_name: Kafetzopoulos, Ioannis
last_name: Kafetzopoulos
- first_name: Stephen J.
full_name: Clark, Stephen J.
last_name: Clark
- first_name: Laura
full_name: Benson, Laura
last_name: Benson
- first_name: Fatima
full_name: Santos, Fatima
last_name: Santos
- first_name: Felix
full_name: Krueger, Felix
last_name: Krueger
- first_name: Simon
full_name: Walker, Simon
last_name: Walker
- first_name: Wolf
full_name: Reik, Wolf
last_name: Reik
- first_name: Steffen
full_name: Rulands, Steffen
last_name: Rulands
citation:
ama: Olmeda F, Lohoff T, Kafetzopoulos I, et al. Scaling and self-similarity in
the formation of the embryonic epigenome. Nature Physics. 2026. doi:10.1038/s41567-026-03263-x
apa: Olmeda, F., Lohoff, T., Kafetzopoulos, I., Clark, S. J., Benson, L., Santos,
F., … Rulands, S. (2026). Scaling and self-similarity in the formation of the
embryonic epigenome. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-026-03263-x
chicago: Olmeda, Fabrizio, Tim Lohoff, Ioannis Kafetzopoulos, Stephen J. Clark,
Laura Benson, Fatima Santos, Felix Krueger, Simon Walker, Wolf Reik, and Steffen
Rulands. “Scaling and Self-Similarity in the Formation of the Embryonic Epigenome.”
Nature Physics. Springer Nature, 2026. https://doi.org/10.1038/s41567-026-03263-x.
ieee: F. Olmeda et al., “Scaling and self-similarity in the formation of
the embryonic epigenome,” Nature Physics. Springer Nature, 2026.
ista: Olmeda F, Lohoff T, Kafetzopoulos I, Clark SJ, Benson L, Santos F, Krueger
F, Walker S, Reik W, Rulands S. 2026. Scaling and self-similarity in the formation
of the embryonic epigenome. Nature Physics.
mla: Olmeda, Fabrizio, et al. “Scaling and Self-Similarity in the Formation of the
Embryonic Epigenome.” Nature Physics, Springer Nature, 2026, doi:10.1038/s41567-026-03263-x.
short: F. Olmeda, T. Lohoff, I. Kafetzopoulos, S.J. Clark, L. Benson, F. Santos,
F. Krueger, S. Walker, W. Reik, S. Rulands, Nature Physics (2026).
date_created: 2026-05-10T22:02:16Z
date_published: 2026-04-29T00:00:00Z
date_updated: 2026-05-11T06:22:47Z
day: '29'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1038/s41567-026-03263-x
ec_funded: 1
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41567-026-03263-x
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Scaling and self-similarity in the formation of the embryonic epigenome
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21848'
abstract:
- lang: eng
text: 'Despite the success of mRNA therapeutics, challenges remain in optimizing
immune responses and minimizing side effects. Cell-specific antigen delivery may
help reduce required doses and improve vaccine efficacy. In this study, we report
on a targeted delivery system for mRNA to a specific subset of skin-resident antigen-presenting
cells: Langerhans cells. By functionalizing lipid nanoparticles with a langerin-specific
glycomimetic ligand, we achieve selective mRNA delivery to both murine and human
primary Langerhans cells with minimal off-target uptake, at the same time resulting
in significantly increased mRNA translation. This targeted mRNA delivery not only
enhances antigen presentation and T-cell responses but also enables dose-sparing
and superior antitumor immunity compared with conventional immunization in a B16-OVA
tumor model. Importantly, our platform’s high compatibility with various lipid
nanoparticle formulations offers a flexible and precise tool for skin-directed
mRNA delivery.'
acknowledged_ssus:
- _id: PreCl
acknowledgement: We thank Mareike Rentzsch for her intellectual contributions during
the course of our discussions. We thank Michael Schunn from the Preclinical Facility
of the Institute of Science and Technology Austria for his continuous technical
support. Guarantor of the work is FS. This project was supported by “Seedfinancing”
(P2282679) of the Austrian Federal Ministry of Digital and Economic Affairs and
the Ministry of Climate Action and Energy, handled by the Austrian Wirtschaftsservice,
as well as by...
article_processing_charge: No
article_type: original
author:
- first_name: Klara
full_name: Klein, Klara
last_name: Klein
- first_name: Litty
full_name: Johnson, Litty
last_name: Johnson
- first_name: Ramona
full_name: Rîca, Ramona
last_name: Rîca
- first_name: Mirza
full_name: Sarcevic, Mirza
last_name: Sarcevic
- first_name: Gabriele
full_name: Carta, Gabriele
last_name: Carta
- first_name: Saskia
full_name: Seiser, Saskia
last_name: Seiser
- first_name: Adelheid
full_name: Elbe-Bürger, Adelheid
last_name: Elbe-Bürger
- first_name: Freyja
full_name: Langer, Freyja
id: 3C1BE782-F248-11E8-B48F-1D18A9856A87
last_name: Langer
- first_name: Nowras
full_name: Rahhal, Nowras
last_name: Rahhal
- first_name: Christoph
full_name: Rademacher, Christoph
last_name: Rademacher
- first_name: Robert
full_name: Wawrzinek, Robert
last_name: Wawrzinek
- first_name: Federica
full_name: Quattrone, Federica
last_name: Quattrone
- first_name: Florian
full_name: Sparber, Florian
last_name: Sparber
citation:
ama: 'Klein K, Johnson L, Rîca R, et al. Langerhans cell–targeted mRNA delivery:
A strategy for dose-sparing and enhanced antitumor immunity. Journal of Investigative
Dermatology. doi:10.1016/j.jid.2026.03.026'
apa: 'Klein, K., Johnson, L., Rîca, R., Sarcevic, M., Carta, G., Seiser, S., … Sparber,
F. (n.d.). Langerhans cell–targeted mRNA delivery: A strategy for dose-sparing
and enhanced antitumor immunity. Journal of Investigative Dermatology.
Elsevier. https://doi.org/10.1016/j.jid.2026.03.026'
chicago: 'Klein, Klara, Litty Johnson, Ramona Rîca, Mirza Sarcevic, Gabriele Carta,
Saskia Seiser, Adelheid Elbe-Bürger, et al. “Langerhans Cell–Targeted MRNA Delivery:
A Strategy for Dose-Sparing and Enhanced Antitumor Immunity.” Journal of Investigative
Dermatology. Elsevier, n.d. https://doi.org/10.1016/j.jid.2026.03.026.'
ieee: 'K. Klein et al., “Langerhans cell–targeted mRNA delivery: A strategy
for dose-sparing and enhanced antitumor immunity,” Journal of Investigative
Dermatology. Elsevier.'
ista: 'Klein K, Johnson L, Rîca R, Sarcevic M, Carta G, Seiser S, Elbe-Bürger A,
Langer F, Rahhal N, Rademacher C, Wawrzinek R, Quattrone F, Sparber F. Langerhans
cell–targeted mRNA delivery: A strategy for dose-sparing and enhanced antitumor
immunity. Journal of Investigative Dermatology.'
mla: 'Klein, Klara, et al. “Langerhans Cell–Targeted MRNA Delivery: A Strategy for
Dose-Sparing and Enhanced Antitumor Immunity.” Journal of Investigative Dermatology,
Elsevier, doi:10.1016/j.jid.2026.03.026.'
short: K. Klein, L. Johnson, R. Rîca, M. Sarcevic, G. Carta, S. Seiser, A. Elbe-Bürger,
F. Langer, N. Rahhal, C. Rademacher, R. Wawrzinek, F. Quattrone, F. Sparber, Journal
of Investigative Dermatology (n.d.).
date_created: 2026-05-10T22:02:16Z
date_published: 2026-04-07T00:00:00Z
date_updated: 2026-05-11T06:07:32Z
day: '07'
department:
- _id: PreCl
doi: 10.1016/j.jid.2026.03.026
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2025.06.25.661517
month: '04'
oa: 1
oa_version: Preprint
publication: Journal of Investigative Dermatology
publication_identifier:
eissn:
- 1523-1747
issn:
- 0022-202X
publication_status: inpress
publisher: Elsevier
scopus_import: '1'
status: public
title: 'Langerhans cell–targeted mRNA delivery: A strategy for dose-sparing and enhanced
antitumor immunity'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21844'
abstract:
- lang: eng
text: Little red dots (LRDs) are a newly identified class of broad-line active galactic
nuclei (AGNs) with a distinctive V-shaped spectrum characterized by red optical
and blue UV continuum emission. Their high abundance at redshifts of z ∼ 6–8 and
decline at lower redshifts suggest a transient origin. We propose that the spectral
shape of LRDs originates from compact binary black hole systems, in which each
black hole is surrounded by a mini-disk and embedded within a larger circumbinary
disk. With a binary separation of ≲103 Schwarzschild radii, the Wien tail of a
T ≃ 5000 K blackbody spectrum at the inner edge of the circumbinary disk produces
the red optical emission, while the mini-disks power the UV continuum. Binary
torques carve out a gap between the circumbinary disk and the mini-disks, setting
the turnover wavelength of the V-shaped spectrum around the Balmer limit. This
scenario naturally reproduces LRD spectra requiring only modest dust attenuation
(AV ≲ 1 mag), resolving overestimated luminosities for LRDs in previous studies
and alleviating a tension with the so-called Sołtan argument. This model predicts
distinct spectral evolution as the binary orbit decays through binary disk interactions
and gravitational-wave (GW) emission, linking early-stage “proto-LRD” binaries
to the broader AGN population and late-stage “LRD descendants” to coalescing binaries
detectable in GW experiments.
acknowledgement: We greatly thank Kenta Hotokezaka and Hanpu Liu for constructive
discussions. K.I., J.S., X.C., and L.C.H. acknowledge support from National Natural
Science Foundation of China (grant Nos. 12573015, 1251101148, 12233001, and 12473037),
the Beijing Natural Science Foundation (grant No. IS25003), and the China Manned
Space Program (grant No. CMS-CSST-2025-A09). J.S. is also supported by “The Fundamental
Research Funds for the Central Universities, Peking University” (grant No. 7100604896).
Z.H. acknowledges support by US NSF grant AST-2006176 and by NASA grant Nos. 80NSSC24K0440
and 80NSSC22K0822.
article_number: '25'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Kohei
full_name: Inayoshi, Kohei
last_name: Inayoshi
- first_name: Jinyi
full_name: Shangguan, Jinyi
last_name: Shangguan
- first_name: Xian
full_name: Chen, Xian
last_name: Chen
- first_name: Luis C.
full_name: Ho, Luis C.
last_name: Ho
- first_name: Zoltán
full_name: Haiman, Zoltán
id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
last_name: Haiman
orcid: 0000-0003-3633-5403
citation:
ama: Inayoshi K, Shangguan J, Chen X, Ho LC, Haiman Z. The emergence of Little Red
Dots from binary massive black holes. The Astrophysical Journal. 2026;1002(1).
doi:10.3847/1538-4357/ae548d
apa: Inayoshi, K., Shangguan, J., Chen, X., Ho, L. C., & Haiman, Z. (2026).
The emergence of Little Red Dots from binary massive black holes. The Astrophysical
Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ae548d
chicago: Inayoshi, Kohei, Jinyi Shangguan, Xian Chen, Luis C. Ho, and Zoltán Haiman.
“The Emergence of Little Red Dots from Binary Massive Black Holes.” The Astrophysical
Journal. IOP Publishing, 2026. https://doi.org/10.3847/1538-4357/ae548d.
ieee: K. Inayoshi, J. Shangguan, X. Chen, L. C. Ho, and Z. Haiman, “The emergence
of Little Red Dots from binary massive black holes,” The Astrophysical Journal,
vol. 1002, no. 1. IOP Publishing, 2026.
ista: Inayoshi K, Shangguan J, Chen X, Ho LC, Haiman Z. 2026. The emergence of Little
Red Dots from binary massive black holes. The Astrophysical Journal. 1002(1),
25.
mla: Inayoshi, Kohei, et al. “The Emergence of Little Red Dots from Binary Massive
Black Holes.” The Astrophysical Journal, vol. 1002, no. 1, 25, IOP Publishing,
2026, doi:10.3847/1538-4357/ae548d.
short: K. Inayoshi, J. Shangguan, X. Chen, L.C. Ho, Z. Haiman, The Astrophysical
Journal 1002 (2026).
date_created: 2026-05-10T22:02:14Z
date_published: 2026-05-01T00:00:00Z
date_updated: 2026-05-11T07:09:12Z
day: '01'
ddc:
- '520'
department:
- _id: ZoHa
doi: 10.3847/1538-4357/ae548d
external_id:
arxiv:
- '2505.05322'
file:
- access_level: open_access
checksum: b4506dfef3dd6da335775071d8f2a0a6
content_type: application/pdf
creator: dernst
date_created: 2026-05-11T07:07:22Z
date_updated: 2026-05-11T07:07:22Z
file_id: '21853'
file_name: 2026_AstrophysicalJour_Inayoshi.pdf
file_size: 3041897
relation: main_file
success: 1
file_date_updated: 2026-05-11T07:07:22Z
has_accepted_license: '1'
intvolume: ' 1002'
issue: '1'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: The emergence of Little Red Dots from binary massive black holes
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1002
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21860'
abstract:
- lang: eng
text: Glutamate excitotoxicity is a cell death mechanism triggered by accumulation
of glutamate in the extracellular space. The α-ketoglutarate dehydrogenase complex
(αKGDHC), an enzyme of the tricarboxylic acid cycle, represents a branching point
controlling glutamate formation and its consumption as a fuel. Hence, modulation
of the activity of αKGDHC might alter the amount of glutamate available for excitotoxic
effects. To address this hypothesis, hippocampal neurons in primary co-culture
with glial cells were exposed to zero-Mg2 buffer to elicit excitotoxicity through
N-methyl-D-aspartic acid (NMDA) receptor disinhibition. Pretreatment of the cultures
with succinyl phosphonate, to inhibit αKGDHC, enhanced excitotoxity, whereas promotion
of αKGDHC activity by pretreatment with thiamine caused an opposite action. Moreover,
NMDA receptor currents – but not those mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic
acid (AMPA) receptors – were potentiated in neurons with impaired αKGDHC activity
and diminished in neurons with boosted αKGDHC activity. The sensitization of NMDA
receptors involved mGluR1 activation and was accompanied by enhanced neuronal
discharge activity, elevated basal cytosolic Ca2+ levels, and augmented Ca2+ responses
evoked by glutamate application. These results suggest that mGluR1-mediated potentiation
of NMDA receptors contributes to a mechanism by which inhibition of αKGDHC might
exacerbate glutamate excitotoxicity.
acknowledgement: The technical assistance by Tanja Wagner and Elena Lilliu is gratefully
acknowledged. This research was funded in whole or in part by the Austrian Science
Fund (FWF) (P36145 to H.K., PAT8605623 to M.H. and P33799 to A.V.K.]. Open Access
funding provided by Medical University of Vienna and the Austrian Science Fund (FWF).
Deposited in PMC for immediate release.
article_number: jcs264420
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Vanessa
full_name: Goeschl, Vanessa
last_name: Goeschl
- first_name: Matej
full_name: Hotka, Matej
last_name: Hotka
- first_name: Bernhard
full_name: Hochreiter, Bernhard
id: e6cab3de-17f6-11ed-9210-c1e42e045e9d
last_name: Hochreiter
- first_name: Karlheinz
full_name: Hilber, Karlheinz
last_name: Hilber
- first_name: Stefan
full_name: Boehm, Stefan
last_name: Boehm
- first_name: Andrey V.
full_name: Kozlov, Andrey V.
last_name: Kozlov
- first_name: Helmut
full_name: Kubista, Helmut
last_name: Kubista
citation:
ama: Goeschl V, Hotka M, Hochreiter B, et al. α-ketoglutarate dehydrogenase complex
activity modulates glutamate excitotoxicity via metabotropic regulation of NMDA
receptors in primary cultures. Journal of Cell Science. 2026;139(8). doi:10.1242/jcs.264420
apa: Goeschl, V., Hotka, M., Hochreiter, B., Hilber, K., Boehm, S., Kozlov, A. V.,
& Kubista, H. (2026). α-ketoglutarate dehydrogenase complex activity modulates
glutamate excitotoxicity via metabotropic regulation of NMDA receptors in primary
cultures. Journal of Cell Science. The Company of Biologists. https://doi.org/10.1242/jcs.264420
chicago: Goeschl, Vanessa, Matej Hotka, Bernhard Hochreiter, Karlheinz Hilber, Stefan
Boehm, Andrey V. Kozlov, and Helmut Kubista. “α-Ketoglutarate Dehydrogenase Complex
Activity Modulates Glutamate Excitotoxicity via Metabotropic Regulation of NMDA
Receptors in Primary Cultures.” Journal of Cell Science. The Company of
Biologists, 2026. https://doi.org/10.1242/jcs.264420.
ieee: V. Goeschl et al., “α-ketoglutarate dehydrogenase complex activity
modulates glutamate excitotoxicity via metabotropic regulation of NMDA receptors
in primary cultures,” Journal of Cell Science, vol. 139, no. 8. The Company
of Biologists, 2026.
ista: Goeschl V, Hotka M, Hochreiter B, Hilber K, Boehm S, Kozlov AV, Kubista H.
2026. α-ketoglutarate dehydrogenase complex activity modulates glutamate excitotoxicity
via metabotropic regulation of NMDA receptors in primary cultures. Journal of
Cell Science. 139(8), jcs264420.
mla: Goeschl, Vanessa, et al. “α-Ketoglutarate Dehydrogenase Complex Activity Modulates
Glutamate Excitotoxicity via Metabotropic Regulation of NMDA Receptors in Primary
Cultures.” Journal of Cell Science, vol. 139, no. 8, jcs264420, The Company
of Biologists, 2026, doi:10.1242/jcs.264420.
short: V. Goeschl, M. Hotka, B. Hochreiter, K. Hilber, S. Boehm, A.V. Kozlov, H.
Kubista, Journal of Cell Science 139 (2026).
date_created: 2026-05-11T10:52:27Z
date_published: 2026-04-27T00:00:00Z
date_updated: 2026-05-12T06:40:18Z
day: '27'
ddc:
- '570'
department:
- _id: Bio
doi: 10.1242/jcs.264420
external_id:
pmid:
- '41834724'
file:
- access_level: open_access
checksum: 8db35c97588c2f6ef88c7e8d5924cf8c
content_type: application/pdf
creator: dernst
date_created: 2026-05-12T06:27:54Z
date_updated: 2026-05-12T06:27:54Z
file_id: '21861'
file_name: 2026_JourCellScience_Goeschl.pdf
file_size: 1957057
relation: main_file
success: 1
file_date_updated: 2026-05-12T06:27:54Z
has_accepted_license: '1'
intvolume: ' 139'
issue: '8'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
publication: Journal of Cell Science
publication_identifier:
eissn:
- 1477-9137
issn:
- 0021-9533
publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
scopus_import: '1'
status: public
title: α-ketoglutarate dehydrogenase complex activity modulates glutamate excitotoxicity
via metabotropic regulation of NMDA receptors in primary cultures
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 139
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21842'
abstract:
- lang: eng
text: "AM CVn stars are ultra-compact semi-detached binaries consisting of a white
dwarf primary and a hydrogen-depleted secondary. In this\r\npaper, we present
spectroscopic and photometric results of 15 transient sources pre-classified as
AM CVn candidates. Our analysis confirms\r\n9 systems of the type AM CVn, 3 hydrogen-rich
cataclysmic variables (accreting white dwarfs with near-main-sequence stars for
donors),\r\nand 3 systems that could be evolved cataclysmic variables. Eight of
the AM CVn stars are analysed spectroscopically for the first time,\r\nwhich increases
the number of spectroscopically confirmed AM CVns by about 10%. TESS data revealed
the orbital period of the AM CVn\r\nstar ASASSN-20pv to be Porb =27.282 min, which
helps to constrain the possible values of its mass ratio. TESS also helped to
determine\r\nthe superhump periods of one AM CVn star (ASASSN-19ct, Psh =30.94
min) and two cataclysmic variables we classify as WZ Sge stars\r\n(Psh =90.77
min for ZTF18aaaasnn and Psh =91.6min for ASASSN-15na).We identified very different
abundances in the spectra of theAM\r\nCVns binaries ASASSN-15kf and ASASSN-20pv
(both Porb ∼27.5min), suggesting different type of donors. Six of the studied
AMCVns are\r\nX-ray sources, which helped to determine their mass accretion rates.
Photometry shows that the duration of all the superoutbursts detected\r\nin the
AM CVns is consistent with expectations from the disc instability model. Finally,
we provide refined criteria for the identification of\r\nnew systems using all-sky
surveys such as LSST."
acknowledgement: "We are grateful to the anonymous referee for providing\r\nus with
useful comments and suggestions that improved our manuscript.\r\nJK and LRS acknowledge
support from NASA grants NNH22ZDA001N-6152\r\nand 80NSSC24K0638. MPM is partially
supported by the Swiss National\r\nScience Foundation IZSTZ0_216537 and by UNAM
PAPIIT-IG101224. Based\r\non observations obtained at the international Gemini Observatory,
a program\r\nof NSF NOIRLab, which is managed by the Association of Universities
for\r\nResearch in Astronomy (AURA) under a cooperative agreement with the U.S.\r\nNational
Science Foundation on behalf of the Gemini Observatory partnership:\r\nthe U.S.
National Science Foundation (United States), National Research\r\nCouncil (Canada),
Agencia Nacional de Investigación y Desarrollo (Chile), Ministerio de Ciencia, Tecnología
e Innovación (Argentina), Ministério\r\nda Ciência, Tecnologia, Inovações e Comunicações
(Brazil), and Korea\r\nAstronomy and Space Science Institute (Republic of Korea).
The Gemini\r\ndata were obtained from programs GN-2023B-Q-310 and GS-2024A-Q-311\r\n(PI:
Rivera Sandoval) and processed using DRAGONS (Data Reduction for\r\nAstronomy from
Gemini Observatory North and South) The Digitized Sky\r\nSurveys were produced at
the Space Telescope Science Institute under U.S.\r\nGovernment grant NAG W-2166.
The images of these surveys are based on\r\nphotographic data obtained using the
Oschin Schmidt Telescope on Palomar\r\nMountain and the UK Schmidt Telescope. The
plates were processed into the\r\npresent compressed digital form with the permission
of these institutions.\r\nThe National Geographic Society – Palomar Observatory
Sky Atlas (POSS-I)\r\nwas made by the California Institute of Technology with grants
from the\r\nNational Geographic Society. The Second Palomar Observatory Sky Survey\r\n(POSS-II)
was made by the California Institute of Technology with funds\r\nfrom the National
Science Foundation, the National Geographic Society, the\r\nSloan Foundation, the
Samuel Oschin Foundation, and the Eastman Kodak\r\nCorporation. The Oschin Schmidt
Telescope is operated by the California\r\nInstitute of Technology and Palomar Observatory.
The UK Schmidt Telescope\r\nwas operated by the Royal Observatory Edinburgh, with
funding from the\r\nUK Science and Engineering Research Council (later the UK Particle
Physics\r\nand Astronomy Research Council), until 1988 June, and thereafter by the\r\nAnglo-Australian
Observatory. The blue plates of the southern Sky Atlas\r\nand its Equatorial Extension
(together known as the SERC-J), as well as the\r\nEquatorial Red (ER), and the Second
Epoch [red] Survey (SES) were all taken\r\nwith the UK Schmidt. Supplemental funding
for sky-survey work at the ST\r\nScI is provided by the European Southern Observatory.
Based on observations\r\nobtained with the Samuel Oschin Telescope 48-inch and the
60-inch Telescope\r\nat the Palomar Observatory as part of the Zwicky Transient
Facility project.\r\nZTF is supported by the National Science Foundation under Grants
No. AST-\r\n1440341 and AST-2034437 and a collaboration including current partners\r\nCaltech,
IPAC, the Oskar Klein Center at Stockholm University, the University\r\nof Maryland,
University of California, Berkeley, the University of Wisconsin\r\nat Milwaukee,
University of Warwick, Ruhr University, Cornell University,\r\nNorthwestern University,
and Drexel University. Operations are conducted\r\nby COO, IPAC, and UW. This work
has used data from the European\r\nSpace Agency (ESA) mission Gaia (https://www.cosmos.esa.int/gaia),\r\nprocessed
by the Gaia Data Processing and Analysis Consortium (DPAC,\r\nhttps://www.cosmos.esa.int/web/gaia/dpac/consortium).
Funding for the\r\nDPAC has been provided by national institutions, in particular,
the institutions\r\nparticipating in the Gaia Multilateral Agreement. We acknowledge
with\r\nthanks the variable star observations from the AAVSO International Database\r\ncontributed
by observers worldwide and used in this research. This paper\r\nincludes data collected
by the TESS mission. Funding for the TESS mission\r\nis provided by the NASA Science
Mission Directorate. Some of the data\r\npresented in this paper were obtained from
the B. Mikulski Archive for Space\r\nTelescopes (MAST). This research has made use
of the SIMBAD database,\r\noperated at CDS, Strasbourg, France. This research has
made use of ‘Aladin\r\nsky atlas’ developed at CDS, Strasbourg Observatory, France.
This research\r\nhas made use of the VizieR catalogue access tool, CDS, Strasbourg,
France."
article_number: e052
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Jan
full_name: Kára, Jan
last_name: Kára
- first_name: Liliana
full_name: Rivera Sandoval, Liliana
last_name: Rivera Sandoval
- first_name: Wendy
full_name: Mendoza, Wendy
last_name: Mendoza
- first_name: Thomas
full_name: Maccarone, Thomas
last_name: Maccarone
- first_name: Manuel
full_name: Pichardo Marcano, Manuel
last_name: Pichardo Marcano
- first_name: Luis E.
full_name: Salazar Manzano, Luis E.
last_name: Salazar Manzano
- first_name: Ryan J.
full_name: Oelkers, Ryan J.
last_name: Oelkers
- first_name: Joannes C
full_name: van Roestel, Joannes C
id: 4d122fc8-6083-11f0-87a5-97d68b860333
last_name: van Roestel
citation:
ama: Kára J, Rivera Sandoval L, Mendoza W, et al. A study of transients from ground-based
surveys reveals new ultra-compact accreting white dwarf binaries. Publications
of the Astronomical Society of Australia. 2026;43. doi:10.1017/pasa.2026.10184
apa: Kára, J., Rivera Sandoval, L., Mendoza, W., Maccarone, T., Pichardo Marcano,
M., Salazar Manzano, L. E., … van Roestel, J. C. (2026). A study of transients
from ground-based surveys reveals new ultra-compact accreting white dwarf binaries.
Publications of the Astronomical Society of Australia. Cambridge University
Press. https://doi.org/10.1017/pasa.2026.10184
chicago: Kára, Jan, Liliana Rivera Sandoval, Wendy Mendoza, Thomas Maccarone, Manuel
Pichardo Marcano, Luis E. Salazar Manzano, Ryan J. Oelkers, and Joannes C van
Roestel. “A Study of Transients from Ground-Based Surveys Reveals New Ultra-Compact
Accreting White Dwarf Binaries.” Publications of the Astronomical Society of
Australia. Cambridge University Press, 2026. https://doi.org/10.1017/pasa.2026.10184.
ieee: J. Kára et al., “A study of transients from ground-based surveys reveals
new ultra-compact accreting white dwarf binaries,” Publications of the Astronomical
Society of Australia, vol. 43. Cambridge University Press, 2026.
ista: Kára J, Rivera Sandoval L, Mendoza W, Maccarone T, Pichardo Marcano M, Salazar
Manzano LE, Oelkers RJ, van Roestel JC. 2026. A study of transients from ground-based
surveys reveals new ultra-compact accreting white dwarf binaries. Publications
of the Astronomical Society of Australia. 43, e052.
mla: Kára, Jan, et al. “A Study of Transients from Ground-Based Surveys Reveals
New Ultra-Compact Accreting White Dwarf Binaries.” Publications of the Astronomical
Society of Australia, vol. 43, e052, Cambridge University Press, 2026, doi:10.1017/pasa.2026.10184.
short: J. Kára, L. Rivera Sandoval, W. Mendoza, T. Maccarone, M. Pichardo Marcano,
L.E. Salazar Manzano, R.J. Oelkers, J.C. van Roestel, Publications of the Astronomical
Society of Australia 43 (2026).
date_created: 2026-05-07T08:55:00Z
date_published: 2026-03-27T00:00:00Z
date_updated: 2026-05-12T06:57:40Z
day: '27'
ddc:
- '520'
department:
- _id: IlCa
doi: 10.1017/pasa.2026.10184
file:
- access_level: open_access
checksum: f8f3cd3765948e8b276176c71c9d4e02
content_type: application/pdf
creator: dernst
date_created: 2026-05-12T06:54:10Z
date_updated: 2026-05-12T06:54:10Z
file_id: '21862'
file_name: 2026_PublAstronomicalSocAustralia_Kara.pdf
file_size: 3681016
relation: main_file
success: 1
file_date_updated: 2026-05-12T06:54:10Z
has_accepted_license: '1'
intvolume: ' 43'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: Publications of the Astronomical Society of Australia
publication_identifier:
eissn:
- 1448-6083
issn:
- 1323-3580
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: A study of transients from ground-based surveys reveals new ultra-compact accreting
white dwarf binaries
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 43
year: '2026'
...
---
_id: '21864'
alternative_title:
- ISTA Technical Report
article_processing_charge: No
author:
- first_name: '1'
full_name: Anonymous, 1
last_name: Anonymous
- first_name: '2'
full_name: Anonymous, 2
last_name: Anonymous
- first_name: '3'
full_name: Anonymous, 3
last_name: Anonymous
citation:
ama: Anonymous 1, Anonymous 2, Anonymous 3. Mechanism of Tissue Tension Homeostasis
during Embryogenesis. Institute of Science and Technology Austria
apa: Anonymous, 1, Anonymous, 2, & Anonymous, 3. (n.d.). Mechanism of tissue
tension homeostasis during embryogenesis. Institute of Science and Technology
Austria.
chicago: Anonymous, 1, 2 Anonymous, and 3 Anonymous. Mechanism of Tissue Tension
Homeostasis during Embryogenesis. Institute of Science and Technology Austria,
n.d.
ieee: 1 Anonymous, 2 Anonymous, and 3 Anonymous, Mechanism of tissue tension
homeostasis during embryogenesis. Institute of Science and Technology Austria.
ista: Anonymous 1, Anonymous 2, Anonymous 3. Mechanism of tissue tension homeostasis
during embryogenesis, Institute of Science and Technology Austria, 32p.
mla: Anonymous, 1, et al. Mechanism of Tissue Tension Homeostasis during Embryogenesis.
Institute of Science and Technology Austria.
short: 1 Anonymous, 2 Anonymous, 3 Anonymous, Mechanism of Tissue Tension Homeostasis
during Embryogenesis, Institute of Science and Technology Austria, n.d.
date_created: 2026-05-12T12:52:44Z
date_published: 2026-05-13T00:00:00Z
date_updated: 2026-05-13T06:26:39Z
day: '13'
ddc:
- '570'
file:
- access_level: open_access
checksum: 1512170d78f9f31025c87b3a03c62f0c
content_type: application/pdf
creator: nhino
date_created: 2026-05-12T12:43:32Z
date_updated: 2026-05-12T12:43:32Z
file_id: '21865'
file_name: Main_text_and_figures.pdf
file_size: 10079104
relation: main_file
success: 1
- access_level: open_access
checksum: bee92c26b42433e4ff5ca3f17e3f0640
content_type: application/pdf
creator: nhino
date_created: 2026-05-12T12:44:02Z
date_updated: 2026-05-12T12:44:02Z
file_id: '21866'
file_name: Supplementary_figures.pdf
file_size: 1820979
relation: main_file
success: 1
- access_level: open_access
checksum: 9d9ab89c372142f2ffb6c8c625334d7f
content_type: video/mp4
creator: nhino
date_created: 2026-05-12T12:44:09Z
date_updated: 2026-05-12T12:44:09Z
file_id: '21867'
file_name: Supplementary_Video1.mp4
file_size: 10349451
relation: main_file
success: 1
- access_level: closed
checksum: 3e220d1cc8f883bef02eaf5d810cd911
content_type: text/plain
creator: dernst
date_created: 2026-05-13T06:11:26Z
date_updated: 2026-05-13T06:11:26Z
file_id: '21874'
file_name: authors.txt
file_size: 91
relation: main_file
file_date_updated: 2026-05-13T06:11:26Z
has_accepted_license: '1'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Preprint
page: '32'
publication_identifier:
eissn:
- 2664-1690
publication_status: draft
publisher: Institute of Science and Technology Austria
status: public
title: Mechanism of tissue tension homeostasis during embryogenesis
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21837'
abstract:
- lang: eng
text: 'In a warming world of glacier changes, the scientific community has dedicated
increasing attention to debris-covered glaciers and their response to climate.
A variety of models with distinct complexity and data requirements have been developed
and widely used to simulate melt under debris at different sites and scales, but
their skills have never been compared. As part of the activities of the International
Association of Cryospheric Sciences (IACS) Debris Covered Glacier Working Group,
we present an intercomparison exercise aimed at advancing our understanding of
model skills in simulating ice melt under a debris layer. We compare 15 models
with different complexity at nine sites in the European Alps, Caucasus, Chilean
Andes, Nepalese Himalaya and the Southern Alps of New Zealand, over one melt season.
We run the models with measured meteorological data from automatic weather stations
and estimated or measured debris properties. We consider four main model categories:
(i) energy balance models that calculate melt by solving the physics of heat transfer
to the debris layer, but require a high amount of input data; (ii) a simplified
energy balance model; (iii) enhanced temperature-index models; and (iv) simple
empirical temperature-index models that have been extensively used given their
low data requirement but require calibration of their empirical parameters. Model
performance is evaluated using on-site measurements of sub-debris melt (for all
models) and surface temperature (for models based on the surface energy balance).
Our results show that physically-based energy balance models and empirical temperature-index
models perform in a distinct manner. At one end of the spectrum, simple temperature-index
models are accurate when recalibrated or when using site-specific literature parameters,
and show poor results when parameters are uncalibrated. At the other end, energy
balance models show a range of performance: the most accurate energy balance models
are those with the highest degree of complexity at the atmosphere-debris interface.
An important data gap emerged from our experiment: the poor performance of all
models at three sites was related to the poor knowledge of debris properties,
and specifically of thermal conductivity. Future work should focus on both: (i) consistent
data acquisition to evaluate existing models and support new model developments;
(ii) advancing models by accounting for processes such as debris-snow interactions,
moisture in the debris and refreezing. We suggest that a systematic effort of
model development using a common model framework could be carried out in phase
II of the Working Group.'
acknowledgement: "This project has received funding from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme
grant agreement No\r\n772751, RAVEN, “Rapid mass losses of debris covered glaciers
in\r\nHigh Mountain Asia”. It was also supported by the SNSF RENOIR\r\nproject “Resolving
the thickness of debris on Earth’s glaciers and\r\nits rate of change (RENOIR)”,
project number 204322.\r\nDavid Rounce received support from NASA-ROSES program\r\ngrants
NNX17AB27G and 80NSSC17K0566. Walter Immerzeel\r\nand Jakob Steiner acknowledge
support from the European Research Council (ERC) under the European Union’s Horizon
2020\r\nresearch and innovation program (grant agreement no. 676819).\r\nBen Brock
acknowledges support from the EU/FP7 ACQWA\r\n(Assessing Climate impacts on the
Quantity and quality of WAter) project, NERC grant NE/C514282/1, the British Council-Italian\r\nMinistry
of University and Research Partnership programme and\r\nthe Carnegie Trust for the
Universities of Scotland.\r\nThe authors acknowledge the International Association
of\r\nCryospheric Sciences (IACS) for supporting the creation of the\r\nDebris-Covered
Glaciers Working Group (DCG-WG) which enabled this model intercomparison experiment.\r\nThe
authors thank Martin Heynen for producing Figs. 3 and 4.\r\nThe authors thank Duncan
Quincey and Richard Essery for their\r\nconstructive feedback and comments.\r\n"
article_processing_charge: Yes
article_type: original
author:
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
orcid: 0000-0002-5554-8087
- first_name: Adrià
full_name: Fontrodona-Bach, Adrià
id: f06891fd-9f42-11ee-8632-a20971c43046
last_name: Fontrodona-Bach
- first_name: David R.
full_name: Rounce, David R.
last_name: Rounce
- first_name: Catriona Louise
full_name: Fyffe, Catriona Louise
id: 001b0422-8d15-11ed-bc51-cab6c037a228
last_name: Fyffe
- first_name: Leif S.
full_name: Anderson, Leif S.
last_name: Anderson
- first_name: Álvaro
full_name: Ayala, Álvaro
last_name: Ayala
- first_name: Ben W.
full_name: Brock, Ben W.
last_name: Brock
- first_name: Pascal
full_name: Buri, Pascal
last_name: Buri
- first_name: Stefan
full_name: Fugger, Stefan
last_name: Fugger
- first_name: Koji
full_name: Fujita, Koji
last_name: Fujita
- first_name: PRATEEK
full_name: GANTAYAT, PRATEEK
id: 02734268-3e8d-11ef-80a1-cec4a088d004
last_name: GANTAYAT
- first_name: Alexander R.
full_name: Groos, Alexander R.
last_name: Groos
- first_name: Walter
full_name: Immerzeel, Walter
last_name: Immerzeel
- first_name: Marin
full_name: Kneib, Marin
last_name: Kneib
- first_name: Christoph
full_name: Mayer, Christoph
last_name: Mayer
- first_name: Shelley
full_name: MacDonell, Shelley
last_name: MacDonell
- first_name: Michael
full_name: McCarthy, Michael
id: 22a2674a-61ce-11ee-94b5-d18813baf16f
last_name: McCarthy
- first_name: James
full_name: McPhee, James
last_name: McPhee
- first_name: Evan
full_name: Miles, Evan
last_name: Miles
- first_name: Heather
full_name: Purdie, Heather
last_name: Purdie
- first_name: Ekaterina
full_name: Rets, Ekaterina
last_name: Rets
- first_name: Akiko
full_name: Sakai, Akiko
last_name: Sakai
- first_name: Thomas
full_name: Shaw, Thomas
id: 3caa3f91-1f03-11ee-96ce-e0e553054d6e
last_name: Shaw
orcid: 0000-0001-7640-6152
- first_name: Jakob
full_name: Steiner, Jakob
last_name: Steiner
- first_name: Patrick
full_name: Wagnon, Patrick
last_name: Wagnon
- first_name: Alex
full_name: Winter-Billington, Alex
last_name: Winter-Billington
citation:
ama: 'Pellicciotti F, Fontrodona-Bach A, Rounce DR, et al. DCG-MIP: The debris-covered
glacier melt model intercomparison experiment. The Cryosphere. 2026;20(3):1895-1928.
doi:10.5194/tc-20-1895-2026'
apa: 'Pellicciotti, F., Fontrodona-Bach, A., Rounce, D. R., Fyffe, C. L., Anderson,
L. S., Ayala, Á., … Winter-Billington, A. (2026). DCG-MIP: The debris-covered
glacier melt model intercomparison experiment. The Cryosphere. Copernicus
Publications. https://doi.org/10.5194/tc-20-1895-2026'
chicago: 'Pellicciotti, Francesca, Adrià Fontrodona-Bach, David R. Rounce, Catriona
Louise Fyffe, Leif S. Anderson, Álvaro Ayala, Ben W. Brock, et al. “DCG-MIP: The
Debris-Covered Glacier Melt Model Intercomparison Experiment.” The Cryosphere.
Copernicus Publications, 2026. https://doi.org/10.5194/tc-20-1895-2026.'
ieee: 'F. Pellicciotti et al., “DCG-MIP: The debris-covered glacier melt
model intercomparison experiment,” The Cryosphere, vol. 20, no. 3. Copernicus
Publications, pp. 1895–1928, 2026.'
ista: 'Pellicciotti F, Fontrodona-Bach A, Rounce DR, Fyffe CL, Anderson LS, Ayala
Á, Brock BW, Buri P, Fugger S, Fujita K, GANTAYAT P, Groos AR, Immerzeel W, Kneib
M, Mayer C, MacDonell S, McCarthy M, McPhee J, Miles E, Purdie H, Rets E, Sakai
A, Shaw T, Steiner J, Wagnon P, Winter-Billington A. 2026. DCG-MIP: The debris-covered
glacier melt model intercomparison experiment. The Cryosphere. 20(3), 1895–1928.'
mla: 'Pellicciotti, Francesca, et al. “DCG-MIP: The Debris-Covered Glacier Melt
Model Intercomparison Experiment.” The Cryosphere, vol. 20, no. 3, Copernicus
Publications, 2026, pp. 1895–928, doi:10.5194/tc-20-1895-2026.'
short: F. Pellicciotti, A. Fontrodona-Bach, D.R. Rounce, C.L. Fyffe, L.S. Anderson,
Á. Ayala, B.W. Brock, P. Buri, S. Fugger, K. Fujita, P. GANTAYAT, A.R. Groos,
W. Immerzeel, M. Kneib, C. Mayer, S. MacDonell, M. McCarthy, J. McPhee, E. Miles,
H. Purdie, E. Rets, A. Sakai, T. Shaw, J. Steiner, P. Wagnon, A. Winter-Billington,
The Cryosphere 20 (2026) 1895–1928.
corr_author: '1'
date_created: 2026-05-07T08:48:38Z
date_published: 2026-04-02T00:00:00Z
date_updated: 2026-05-18T06:12:56Z
day: '02'
ddc:
- '550'
department:
- _id: FrPe
doi: 10.5194/tc-20-1895-2026
file:
- access_level: open_access
checksum: f15abad4ee360d41a3e8794f068711fc
content_type: application/pdf
creator: dernst
date_created: 2026-05-18T06:07:53Z
date_updated: 2026-05-18T06:07:53Z
file_id: '21886'
file_name: 2026_Cryosphere_Pellicciotti.pdf
file_size: 3168394
relation: main_file
success: 1
file_date_updated: 2026-05-18T06:07:53Z
has_accepted_license: '1'
intvolume: ' 20'
issue: '3'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 1895-1928
publication: The Cryosphere
publication_identifier:
eissn:
- 1994-0424
publication_status: published
publisher: Copernicus Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'DCG-MIP: The debris-covered glacier melt model intercomparison experiment'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21839'
abstract:
- lang: eng
text: "Background & Aims: To develop and validate a CT-based radiomics model to
assess HVPG and predict a composite endpoint of liver-related events (LRE: decompensation
and liver-related death) in patients with cirrhosis.\r\n\r\nMethods: This retrospective
study included 357 cirrhosis patients, who received invasive HVPG measurements,
120 liver-healthy controls (training cohort) and 85 and 100 cirrhosis patients
(internal and external validation cohorts, respectively), and contrast-enhanced
abdominal CTs. After volumetric segmentation of the liver and spleen on CT, Bayesian
parameter optimization was used for selection of extracted features and hyperparameter
tuning in random forest or elastic net models. Prediction accuracy was evaluated
using Pearson correlation coefficients of predicted (’radio-HVPG’) and invasive
HVPG. Discrimination between relevant HVPG cut-offs was determined by receiver
operating characteristic (ROC) analysis. The predictive value of radio-HVPG and
invasive-HVPG for LRE was compared using Cox regression models.\r\n\r\nResults:
Radio-HVPG, predicted by an optimized random forest model based on 74 selected
CT features, correlated with invasive-HVPG and detected clinically significant
portal hypertension (CSPH: HVPG ≥ 10 mmHg) on the internal (Pearson r = 0.63,
AUC 0.89 [95% CI: 0.81–0.96]) and external (Pearson r = 0.62, AUC 0.80 [95% CI:
0.64–0.91]) validation cohorts. Radio-HVPG predicted LRE when adjusting for MELD
and albumin (adjusted HR: 1.14 [95% CI: 1.04–1.25], p = 0.005) and performed similarly
to invasive-HVPG.\r\n\r\nConclusions: Radiomic features accurately predict HVPG
in patients with cirrhosis and allow risk stratification for LRE in a radiomics-clinical
signature."
acknowledgement: "The computational results presented were partly obtained using the
CLIP cluster (https://clip.science/). The authors thank Clemens Watzenboeck from
the Medical University of Vienna for the assistance in code upload and repository
maintenance. The authors dedicate this work to the memory of Martin Watzenboeck,
who served as first author and whose vision and scientific rigor were fundamental
to the conception and completion of this study. Open Access funding provided by
Medizinische Universitat Wien/KEMÖ. This work was supported by the Vienna Science
and Technology Fund (WWTF) through projects VRG15-005 and NXT 19-008 granted to
J.M and the Clinical Research Group MOTION, Medical University of Vienna, Vienna,
Austria – a Clinical Research Group Programme project funded by the Ludwig Boltzmann
Gesellschaft (Grant Nr LBG_KFG_22_32) with funds from the Fonds Zukunft Österreich.\r\n\r\nP-E.R.'s
research laboratory is supported by the Fondation pour la Recherche Médicale (FRM
EQU202303016287), “Institut National de la Santé et de la Recherche Médicale” (ATIP
AVENIR), the “Agence Nationale de la Recherche” (ANR-18-CE14-0006-01, RHU QUID-NASH,
ANR-18-IDEX-0001, ANR-22-CE14-0002) by « Émergence, Ville de Paris », by Fondation
ARC, by the European Union's Horizon 2020 research and innovation programme under
grant agreement No 847949 and by France 2030 RHU LIVER-TRACK."
article_number: e70633
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Celine
full_name: Sin, Celine
last_name: Sin
- first_name: Martin Luther
full_name: Watzenboeck, Martin Luther
last_name: Watzenboeck
- first_name: Eugenia B
full_name: Iofinova, Eugenia B
id: f9a17499-f6e0-11ea-865d-fdf9a3f77117
last_name: Iofinova
orcid: 0000-0002-7778-3221
- first_name: Lorenz
full_name: Balcar, Lorenz
last_name: Balcar
- first_name: Georg
full_name: Semmler, Georg
last_name: Semmler
- first_name: Bernhard
full_name: Scheiner, Bernhard
last_name: Scheiner
- first_name: Katharina
full_name: Lampichler, Katharina
last_name: Lampichler
- first_name: Mattias
full_name: Mandorfer, Mattias
last_name: Mandorfer
- first_name: Lucile
full_name: Moga, Lucile
last_name: Moga
- first_name: Pierre‐Emmanuel
full_name: Rautou, Pierre‐Emmanuel
last_name: Rautou
- first_name: Maxime
full_name: Ronot, Maxime
last_name: Ronot
- first_name: Jörg
full_name: Menche, Jörg
last_name: Menche
- first_name: Thomas
full_name: Reiberger, Thomas
last_name: Reiberger
- first_name: Martina
full_name: Scharitzer, Martina
last_name: Scharitzer
citation:
ama: Sin C, Watzenboeck ML, Iofinova EB, et al. Radiomics‐based assessment of portal
hypertension severity and risk stratification of cirrhotic patients using routine
CT scans. Liver International. 2026;46(5). doi:10.1111/liv.70633
apa: Sin, C., Watzenboeck, M. L., Iofinova, E. B., Balcar, L., Semmler, G., Scheiner,
B., … Scharitzer, M. (2026). Radiomics‐based assessment of portal hypertension
severity and risk stratification of cirrhotic patients using routine CT scans.
Liver International. Wiley. https://doi.org/10.1111/liv.70633
chicago: Sin, Celine, Martin Luther Watzenboeck, Eugenia B Iofinova, Lorenz Balcar,
Georg Semmler, Bernhard Scheiner, Katharina Lampichler, et al. “Radiomics‐based
Assessment of Portal Hypertension Severity and Risk Stratification of Cirrhotic
Patients Using Routine CT Scans.” Liver International. Wiley, 2026. https://doi.org/10.1111/liv.70633.
ieee: C. Sin et al., “Radiomics‐based assessment of portal hypertension severity
and risk stratification of cirrhotic patients using routine CT scans,” Liver
International, vol. 46, no. 5. Wiley, 2026.
ista: Sin C, Watzenboeck ML, Iofinova EB, Balcar L, Semmler G, Scheiner B, Lampichler
K, Mandorfer M, Moga L, Rautou P, Ronot M, Menche J, Reiberger T, Scharitzer M.
2026. Radiomics‐based assessment of portal hypertension severity and risk stratification
of cirrhotic patients using routine CT scans. Liver International. 46(5), e70633.
mla: Sin, Celine, et al. “Radiomics‐based Assessment of Portal Hypertension Severity
and Risk Stratification of Cirrhotic Patients Using Routine CT Scans.” Liver
International, vol. 46, no. 5, e70633, Wiley, 2026, doi:10.1111/liv.70633.
short: C. Sin, M.L. Watzenboeck, E.B. Iofinova, L. Balcar, G. Semmler, B. Scheiner,
K. Lampichler, M. Mandorfer, L. Moga, P. Rautou, M. Ronot, J. Menche, T. Reiberger,
M. Scharitzer, Liver International 46 (2026).
date_created: 2026-05-07T08:51:47Z
date_published: 2026-05-01T00:00:00Z
date_updated: 2026-05-18T07:20:20Z
day: '01'
ddc:
- '570'
doi: 10.1111/liv.70633
external_id:
pmid:
- '41943460'
file:
- access_level: open_access
checksum: fafcc0b88b8e8caed85849627305d9ba
content_type: application/pdf
creator: dernst
date_created: 2026-05-18T07:10:31Z
date_updated: 2026-05-18T07:10:31Z
file_id: '21888'
file_name: 2026_LiverInternational_Sin.pdf
file_size: 3550462
relation: main_file
success: 1
file_date_updated: 2026-05-18T07:10:31Z
has_accepted_license: '1'
intvolume: ' 46'
issue: '5'
keyword:
- computed tomography
- liver
- portal hypertension
- radiomics
- spleen
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
publication: Liver International
publication_identifier:
eissn:
- 1478-3231
issn:
- 1478-3223
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Radiomics‐based assessment of portal hypertension severity and risk stratification
of cirrhotic patients using routine CT scans
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 46
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21840'
abstract:
- lang: eng
text: The transport properties of nanofluidic channels are usually studied under
constant (DC) voltage or pressure driving. However, the frequency response under
sinusoidal (AC) drivings offers rich insights into the time-dependent transport
mechanisms. Inspired by recent electrochemical approaches, we investigate the
couplings between ionic and electronic transport under AC driving. We show that
conduction electrons of the channel walls participate in ionic current via capacitive
electrochemical coupling, defining a critical frequency and length scale where
electron-dominated conductivity emerges. We further analyze how electron–ion coupling
modifies electro-osmotic flows and demonstrate that fluctuation-induced momentum
transfer between the electrolyte and wall electrons produces distinct AC transport
signatures, depending on the charge carrier polarity. Altogether, we establish
a frequency-dependent transport matrix that couples ionic, electronic, and hydrodynamic
flows. These findings establish AC nanofluidic transport as a powerful probe of
interfacial phenomena under confinement and suggest new directions for engineering
nanofluidic functionalities through electron–electrolyte coupling.
acknowledgement: The authors thank Nicolas Chapuis for fruitful discussions. L.B.
acknowledges support from the ERC project n-AQUA under Grant Agreement No. 101071937.
B.C. acknowledges support from the CFM Foundation and the NOMIS Foundation. N.K.
acknowledges support from the Swiss National Science Foundation (SNSF) under Grant
No. CRSK-2_237930.
article_number: '134704'
article_processing_charge: Yes (in subscription journal)
article_type: original
arxiv: 1
author:
- first_name: Baptiste
full_name: Coquinot, Baptiste
id: f8417bd4-f599-11ee-a482-b927e3ed1e8e
last_name: Coquinot
orcid: 0000-0001-5524-596X
- first_name: Mathieu
full_name: Lizée, Mathieu
last_name: Lizée
- first_name: Lydéric
full_name: Bocquet, Lydéric
last_name: Bocquet
- first_name: Nikita
full_name: Kavokine, Nikita
last_name: Kavokine
citation:
ama: Coquinot B, Lizée M, Bocquet L, Kavokine N. Electron–electrolyte coupling in
AC transport through nanofluidic channels. The Journal of Chemical Physics.
2026;164(13). doi:10.1063/5.0313352
apa: Coquinot, B., Lizée, M., Bocquet, L., & Kavokine, N. (2026). Electron–electrolyte
coupling in AC transport through nanofluidic channels. The Journal of Chemical
Physics. AIP Publishing. https://doi.org/10.1063/5.0313352
chicago: Coquinot, Baptiste, Mathieu Lizée, Lydéric Bocquet, and Nikita Kavokine.
“Electron–Electrolyte Coupling in AC Transport through Nanofluidic Channels.”
The Journal of Chemical Physics. AIP Publishing, 2026. https://doi.org/10.1063/5.0313352.
ieee: B. Coquinot, M. Lizée, L. Bocquet, and N. Kavokine, “Electron–electrolyte
coupling in AC transport through nanofluidic channels,” The Journal of Chemical
Physics, vol. 164, no. 13. AIP Publishing, 2026.
ista: Coquinot B, Lizée M, Bocquet L, Kavokine N. 2026. Electron–electrolyte coupling
in AC transport through nanofluidic channels. The Journal of Chemical Physics.
164(13), 134704.
mla: Coquinot, Baptiste, et al. “Electron–Electrolyte Coupling in AC Transport through
Nanofluidic Channels.” The Journal of Chemical Physics, vol. 164, no. 13,
134704, AIP Publishing, 2026, doi:10.1063/5.0313352.
short: B. Coquinot, M. Lizée, L. Bocquet, N. Kavokine, The Journal of Chemical Physics
164 (2026).
date_created: 2026-05-07T08:53:03Z
date_published: 2026-04-07T00:00:00Z
date_updated: 2026-05-18T07:34:57Z
day: '07'
ddc:
- '530'
department:
- _id: MiLe
doi: 10.1063/5.0313352
external_id:
arxiv:
- '2505.02478'
file:
- access_level: open_access
checksum: a896969c829be2a79859bd277f87b44c
content_type: application/pdf
creator: dernst
date_created: 2026-05-18T07:31:23Z
date_updated: 2026-05-18T07:31:23Z
file_id: '21889'
file_name: 2026_JourChemPhysics_Coquinot.pdf
file_size: 5497515
relation: main_file
success: 1
file_date_updated: 2026-05-18T07:31:23Z
has_accepted_license: '1'
intvolume: ' 164'
issue: '13'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
publication: The Journal of Chemical Physics
publication_identifier:
eissn:
- 1089-7690
issn:
- 0021-9606
publication_status: published
publisher: AIP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Electron–electrolyte coupling in AC transport through nanofluidic channels
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 164
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21838'
abstract:
- lang: eng
text: We explore the use of a photoacid in a chemical reaction cycle, which allows
for the controlled sol‐to‐gel transition of a saccharide aldehyde‐based self‐assembling
system. The modulation of the pH with light enables to generate chemical fuels
in situ, thus triggering monomer activation and gelation. Our efforts represent
a promising step toward dissipative self‐assembled systems with a higher degree
of spatiotemporal control.
acknowledgement: J.S.V. and T.M.H. acknowledge funding from ERC-2017-STG “Life-Cycle”
(757910) and ERC-2022-CoG “Suprabot” (101087514). A.L-A. acknowledges the European
Union's Horizon 2020 Research and Innovation Program under the Marie Skłodowska-Curie
grant agreement no. 812868 for Ph.D. funding. R.K. acknowledges support through
the Award for Research Cooperation and High Excellence in Science (ARCHES) from
the Federal German Ministry and Research.
article_number: e70037
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Alvaro
full_name: Lopez‐Acosta, Alvaro
last_name: Lopez‐Acosta
- first_name: Jorge S.
full_name: Valera, Jorge S.
last_name: Valera
- first_name: Rafal
full_name: Klajn, Rafal
id: 8e84690e-1e48-11ed-a02b-a1e6fb8bb53b
last_name: Klajn
- first_name: Thomas M.
full_name: Hermans, Thomas M.
last_name: Hermans
citation:
ama: Lopez‐Acosta A, Valera JS, Klajn R, Hermans TM. Photoacid‐mediated controllable
gelation in a chemical reaction cycle. ChemSystemsChem. 2026;8(3). doi:10.1002/syst.70037
apa: Lopez‐Acosta, A., Valera, J. S., Klajn, R., & Hermans, T. M. (2026). Photoacid‐mediated
controllable gelation in a chemical reaction cycle. ChemSystemsChem. Wiley.
https://doi.org/10.1002/syst.70037
chicago: Lopez‐Acosta, Alvaro, Jorge S. Valera, Rafal Klajn, and Thomas M. Hermans.
“Photoacid‐mediated Controllable Gelation in a Chemical Reaction Cycle.” ChemSystemsChem.
Wiley, 2026. https://doi.org/10.1002/syst.70037.
ieee: A. Lopez‐Acosta, J. S. Valera, R. Klajn, and T. M. Hermans, “Photoacid‐mediated
controllable gelation in a chemical reaction cycle,” ChemSystemsChem, vol.
8, no. 3. Wiley, 2026.
ista: Lopez‐Acosta A, Valera JS, Klajn R, Hermans TM. 2026. Photoacid‐mediated controllable
gelation in a chemical reaction cycle. ChemSystemsChem. 8(3), e70037.
mla: Lopez‐Acosta, Alvaro, et al. “Photoacid‐mediated Controllable Gelation in a
Chemical Reaction Cycle.” ChemSystemsChem, vol. 8, no. 3, e70037, Wiley,
2026, doi:10.1002/syst.70037.
short: A. Lopez‐Acosta, J.S. Valera, R. Klajn, T.M. Hermans, ChemSystemsChem 8 (2026).
date_created: 2026-05-07T08:51:01Z
date_published: 2026-04-06T00:00:00Z
date_updated: 2026-05-18T06:59:10Z
day: '06'
ddc:
- '540'
department:
- _id: RaKl
doi: 10.1002/syst.70037
file:
- access_level: open_access
checksum: c51e985ac2f2cefb273fdf2cc6ab87e4
content_type: application/pdf
creator: dernst
date_created: 2026-05-18T06:29:57Z
date_updated: 2026-05-18T06:29:57Z
file_id: '21887'
file_name: 2026_ChemSystemsChem_LopezAcosta.pdf
file_size: 1118636
relation: main_file
success: 1
file_date_updated: 2026-05-18T06:29:57Z
has_accepted_license: '1'
intvolume: ' 8'
issue: '3'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '04'
oa: 1
oa_version: Published Version
publication: ChemSystemsChem
publication_identifier:
eissn:
- 2570-4206
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Photoacid‐mediated controllable gelation in a chemical reaction cycle
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21841'
abstract:
- lang: eng
text: The long-standing notion that genotypes map to phenotypes through simple one
gene–one trait relationships continues to shape both research in the life sciences
and public understanding, with implications for policy and funding priorities.
Yet this paradigm is increasingly recognized as inadequate for explaining continuous
phenotypic variation and the complex genetic architectures of the genotype–phenotype
map. Modern genetics emerged from the early 20th-century synthesis of Mendelian
and biometric schools of heredity, with R.A. Fisher demonstrating early on how
multiple discrete loci could collectively produce continuous variation. Despite
this fundamental insight, Mendelism—with its focus on single genes and standardized
genetic backgrounds—became the dominant framework, shaping current genetics research
and molecular biology as well as science education. The advent of large-scale
genomic data has revealed yet again the limitations of this reductionist approach.
Evidence from quantitative genetics now shows that most phenotypes arise from
complex networks of many interdependent genes and their dynamic responses to environmental
perturbations. Here we trace the historical roots of how Mendelian classical genetics
departed from the biometric school to create the current predominant paradigm
in genetics, despite fundamentally unresolved issues. Moving on from this one-sided
paradigm will require systematic development of integrative, evolutionarily grounded
experimental approaches that better capture the multigenic and context-dependent
nature of inheritance. Achieving such an extended perspective will require methodological
innovation, including advances in large-scale (e.g. automated) phenotyping. Dedicated
research programs will be necessary to advance a new era of genetic research into
the complex mechanisms underlying phenotypic variation.
acknowledgement: We thank a variety of further colleagues for the many inspiring discussions
on the nature of heredity, especially the workshops in Berlin. Special thanks also
to the Stellenbosch Institute for Advanced Studies (STIAS) to provide DT the leisure
and freedom to write up the first version of this perspective. Thanks also to three
reviewers who have helped to improve the manuscript. Two dedicated symposia on the
topic were funded by the Max-Planck Society.
article_number: iyag024
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Diethard
full_name: Tautz, Diethard
last_name: Tautz
- first_name: Luisa F
full_name: Pallares, Luisa F
last_name: Pallares
- first_name: Leif
full_name: Andersson, Leif
last_name: Andersson
- first_name: Neda
full_name: Barghi, Neda
last_name: Barghi
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Rachael
full_name: Bay, Rachael
last_name: Bay
- first_name: Yingguang Frank
full_name: Chan, Yingguang Frank
last_name: Chan
- first_name: Angela
full_name: Hancock, Angela
last_name: Hancock
- first_name: Tobias S
full_name: Kaiser, Tobias S
last_name: Kaiser
- first_name: Daniel
full_name: Koenig, Daniel
last_name: Koenig
- first_name: Zacharias
full_name: Kontarakis, Zacharias
last_name: Kontarakis
- first_name: Miriam
full_name: Liedvogel, Miriam
last_name: Liedvogel
- first_name: Juliette
full_name: de Meaux, Juliette
last_name: de Meaux
- first_name: Magnus
full_name: Nordborg, Magnus
last_name: Nordborg
- first_name: Abraham A
full_name: Palmer, Abraham A
last_name: Palmer
- first_name: Michael
full_name: Purugganan, Michael
last_name: Purugganan
- first_name: Christian
full_name: Schlötterer, Christian
last_name: Schlötterer
- first_name: Karl
full_name: Schmid, Karl
last_name: Schmid
- first_name: Didier Y R
full_name: Stainier, Didier Y R
last_name: Stainier
- first_name: Detlef
full_name: Weigel, Detlef
last_name: Weigel
- first_name: Jochen B W
full_name: Wolf, Jochen B W
last_name: Wolf
- first_name: Dieter
full_name: Ebert, Dieter
last_name: Ebert
- first_name: Greg
full_name: Gibson, Greg
last_name: Gibson
citation:
ama: 'Tautz D, Pallares LF, Andersson L, et al. Beyond Mendel: A call to revisit
the genotype–phenotype map through new experimental paradigms. Genetics.
2026;232(4). doi:10.1093/genetics/iyag024'
apa: 'Tautz, D., Pallares, L. F., Andersson, L., Barghi, N., Barton, N. H., Bay,
R., … Gibson, G. (2026). Beyond Mendel: A call to revisit the genotype–phenotype
map through new experimental paradigms. Genetics. Oxford University Press.
https://doi.org/10.1093/genetics/iyag024'
chicago: 'Tautz, Diethard, Luisa F Pallares, Leif Andersson, Neda Barghi, Nicholas
H Barton, Rachael Bay, Yingguang Frank Chan, et al. “Beyond Mendel: A Call to
Revisit the Genotype–Phenotype Map through New Experimental Paradigms.” Genetics.
Oxford University Press, 2026. https://doi.org/10.1093/genetics/iyag024.'
ieee: 'D. Tautz et al., “Beyond Mendel: A call to revisit the genotype–phenotype
map through new experimental paradigms,” Genetics, vol. 232, no. 4. Oxford
University Press, 2026.'
ista: 'Tautz D, Pallares LF, Andersson L, Barghi N, Barton NH, Bay R, Chan YF, Hancock
A, Kaiser TS, Koenig D, Kontarakis Z, Liedvogel M, de Meaux J, Nordborg M, Palmer
AA, Purugganan M, Schlötterer C, Schmid K, Stainier DYR, Weigel D, Wolf JBW, Ebert
D, Gibson G. 2026. Beyond Mendel: A call to revisit the genotype–phenotype map
through new experimental paradigms. Genetics. 232(4), iyag024.'
mla: 'Tautz, Diethard, et al. “Beyond Mendel: A Call to Revisit the Genotype–Phenotype
Map through New Experimental Paradigms.” Genetics, vol. 232, no. 4, iyag024,
Oxford University Press, 2026, doi:10.1093/genetics/iyag024.'
short: D. Tautz, L.F. Pallares, L. Andersson, N. Barghi, N.H. Barton, R. Bay, Y.F.
Chan, A. Hancock, T.S. Kaiser, D. Koenig, Z. Kontarakis, M. Liedvogel, J. de Meaux,
M. Nordborg, A.A. Palmer, M. Purugganan, C. Schlötterer, K. Schmid, D.Y.R. Stainier,
D. Weigel, J.B.W. Wolf, D. Ebert, G. Gibson, Genetics 232 (2026).
date_created: 2026-05-07T08:53:40Z
date_published: 2026-04-01T00:00:00Z
date_updated: 2026-05-18T07:51:26Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1093/genetics/iyag024
external_id:
pmid:
- '41701356'
file:
- access_level: open_access
checksum: 5a862c539f9dec4511277ad8927c549c
content_type: application/pdf
creator: dernst
date_created: 2026-05-18T07:48:45Z
date_updated: 2026-05-18T07:48:45Z
file_id: '21890'
file_name: 2026_Genetics_Tautz.pdf
file_size: 542844
relation: main_file
success: 1
file_date_updated: 2026-05-18T07:48:45Z
has_accepted_license: '1'
intvolume: ' 232'
issue: '4'
keyword:
- classic genetics
- quantitative genetics
- genotype–phenotype map
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
publication: Genetics
publication_identifier:
eissn:
- 1943-2631
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Beyond Mendel: A call to revisit the genotype–phenotype map through new experimental
paradigms'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 232
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21882'
abstract:
- lang: eng
text: The nature of little red dots (LRDs) has largely been investigated through
their continuum emission, with lines assumed to arise from a broad-line region.
In this paper, we instead use recombination lines to infer the intrinsic properties
of the central engine. Our analysis first reveals a tension between the ionizing
properties implied from Hα and He ii λ4686. The high Hα EWs require copious H-ionizing
photons, more than the bluest active galactic nucleus (AGN) ionizing spectra can
provide. In contrast, He ii emission is marginally detected, and its low EW is,
at most, consistent with the softest AGN spectra. The low He ii/Hβ (∼10−2, <20× local
AGN median) further points to an unusually soft ionizing spectrum. We extend our
analysis to dense gas envelopes (quasi-star/black-hole star) and find that hydrogen
recombination lines become optically thick and lose diagnostic power, but He ii
remains optically thin and a robust tracer. Photoionization modeling with Cloudy
rules out standard AGN accretion disk spectra. Alternative explanations include
exotic AGN with red rest-optical emission, high average optical depth (>10) from
gas/dust, and soft ionizing spectra with abundant H-ionizing photons, consistent
with, e.g., a cold accretion disk or a composite of AGN and stars. The latter
is an intriguing scenario since high hydrogen densities are highly conducive for
star formation, and nuclear star clusters are found in the vicinity of local massive
black holes. While previous studies have mostly focused on features dominated
by the absorbing hydrogen cloud, the He ii-based diagnostic proposed here represents
a crucial step toward understanding the central engine of LRDs.
acknowledgement: "B.W. thanks Michael Eracleous for valuable discussions. B.W. and
J.L. acknowledge support from JWST-GO-04233.009. B.W. also acknowledges support
provided by NASA through Hubble Fellowship grant HST-HF2-51592.001 awarded by the
Space Telescope Science Institute, which is operated by the Association of Universities
for Research in Astronomy, Inc., for NASA, under the contract NAS 5-26555. K.I.
acknowledges support from the National Natural Science Foundation of China (12573015,
W2532003), the Beijing Natural Science Foundation (IS25003), and the China Manned
Space Program (CMS-CSST-2025-A09). R.E.H. acknowledges support by the German Aerospace
Center (DLR) and the Federal Ministry for Economic Affairs and Energy (BMWi) through
program 50OR2403 “RUBIES.”\r\n\r\nThis work is based on observations made with the
NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski
Archive for Space Telescopes at the Space Telescope Science Institute, which is
operated by the Association of Universities for Research in Astronomy, Inc., under
NASA contract NAS 5-03127 for JWST. These observations are associated with program
# 1433, 2561, 4106, 4233, 5224, 6585. The specific observations analyzed can be
accessed via DOI: 10.17909/9hpc-nc45. Computations for this research were performed
on the Pennsylvania State University’s Institute for Computational and Data Sciences’
Roar supercomputer; and on computational resources managed and supported by Princeton
Research Computing, a consortium of groups including the Princeton Institute for
Computational Science and Engineering (PICSciE) and Research Computing at Princeton
University. Some of the stellar spectra are retrieved from the POLLUX database (pollux.oreme.org)
operated at LUPM (Université de Montpellier—CNRS, France) with the support of the
PNPS and INSU. This publication made use of the NASA Astrophysical Data System for
bibliographic information."
article_number: '10'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Bingjie
full_name: Wang, Bingjie
last_name: Wang
- first_name: Joel
full_name: Leja, Joel
last_name: Leja
- first_name: Harley
full_name: Katz, Harley
last_name: Katz
- first_name: Kohei
full_name: Inayoshi, Kohei
last_name: Inayoshi
- first_name: Nikko J.
full_name: Cleri, Nikko J.
last_name: Cleri
- first_name: Anna
full_name: De Graaff, Anna
last_name: De Graaff
- first_name: Raphael E.
full_name: Hviding, Raphael E.
last_name: Hviding
- first_name: Pieter
full_name: Van Dokkum, Pieter
last_name: Van Dokkum
- first_name: Jenny E.
full_name: Greene, Jenny E.
last_name: Greene
- first_name: Ivo
full_name: Labbé, Ivo
last_name: Labbé
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Ian
full_name: Mcconachie, Ian
last_name: Mcconachie
- first_name: Rohan P.
full_name: Naidu, Rohan P.
last_name: Naidu
- first_name: Erica J.
full_name: Nelson, Erica J.
last_name: Nelson
citation:
ama: 'Wang B, Leja J, Katz H, et al. The missing hard photons of Little Red Dots:
Their incident ionizing spectra resemble massive stars. The Astrophysical Journal.
2026;1003(1). doi:10.3847/1538-4357/ae5bab'
apa: 'Wang, B., Leja, J., Katz, H., Inayoshi, K., Cleri, N. J., De Graaff, A., …
Nelson, E. J. (2026). The missing hard photons of Little Red Dots: Their incident
ionizing spectra resemble massive stars. The Astrophysical Journal. IOP
Publishing. https://doi.org/10.3847/1538-4357/ae5bab'
chicago: 'Wang, Bingjie, Joel Leja, Harley Katz, Kohei Inayoshi, Nikko J. Cleri,
Anna De Graaff, Raphael E. Hviding, et al. “The Missing Hard Photons of Little
Red Dots: Their Incident Ionizing Spectra Resemble Massive Stars.” The Astrophysical
Journal. IOP Publishing, 2026. https://doi.org/10.3847/1538-4357/ae5bab.'
ieee: 'B. Wang et al., “The missing hard photons of Little Red Dots: Their
incident ionizing spectra resemble massive stars,” The Astrophysical Journal,
vol. 1003, no. 1. IOP Publishing, 2026.'
ista: 'Wang B, Leja J, Katz H, Inayoshi K, Cleri NJ, De Graaff A, Hviding RE, Van
Dokkum P, Greene JE, Labbé I, Matthee JJ, Mcconachie I, Naidu RP, Nelson EJ. 2026.
The missing hard photons of Little Red Dots: Their incident ionizing spectra resemble
massive stars. The Astrophysical Journal. 1003(1), 10.'
mla: 'Wang, Bingjie, et al. “The Missing Hard Photons of Little Red Dots: Their
Incident Ionizing Spectra Resemble Massive Stars.” The Astrophysical Journal,
vol. 1003, no. 1, 10, IOP Publishing, 2026, doi:10.3847/1538-4357/ae5bab.'
short: B. Wang, J. Leja, H. Katz, K. Inayoshi, N.J. Cleri, A. De Graaff, R.E. Hviding,
P. Van Dokkum, J.E. Greene, I. Labbé, J.J. Matthee, I. Mcconachie, R.P. Naidu,
E.J. Nelson, The Astrophysical Journal 1003 (2026).
date_created: 2026-05-17T22:02:10Z
date_published: 2026-05-01T00:00:00Z
date_updated: 2026-05-18T08:18:39Z
day: '01'
ddc:
- '520'
department:
- _id: JoMa
doi: 10.3847/1538-4357/ae5bab
external_id:
arxiv:
- '2508.18358'
file:
- access_level: open_access
checksum: ee9ebc8ae2304fec04f24b82ebaac8bc
content_type: application/pdf
creator: dernst
date_created: 2026-05-18T08:17:26Z
date_updated: 2026-05-18T08:17:26Z
file_id: '21891'
file_name: 2026_AstrophysicalJourn_Wang.pdf
file_size: 2584417
relation: main_file
success: 1
file_date_updated: 2026-05-18T08:17:26Z
has_accepted_license: '1'
intvolume: ' 1003'
issue: '1'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The missing hard photons of Little Red Dots: Their incident ionizing spectra
resemble massive stars'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1003
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21884'
abstract:
- lang: eng
text: "We show that a randomly perturbed digraph, where we start with a dense digraph
Dα and add a small number of random edges to it, will typically contain a fixed
orientation of a bounded-degree spanning tree. This answers a question posed by
Araujo, Balogh, Krueger, Piga and Treglown and generalizes the corresponding result
for randomly perturbed graphs by Krivelevich, Kwan and Sudakov. More specifically,
we prove that there exists a constant c=c(α,Δ) such that if \r\nT is an oriented
tree with maximum degree Δ and Dα is an n-vertex digraph with minimum semidegree
αn, then the graph obtained by adding cn uniformly random edges to Dα will contain
T with high probability."
acknowledgement: "We thank the anonymous referees for many helpful comments on an
earlier version of this\r\narticle. Kalina Petrova was supported by grant no. CRSII5
173721 of the Swiss National\r\nScience Foundation, and by the European Union’s
Horizon 2020 research and innovation\r\nprogramme under the Marie Sk lodowska-Curie
grant agreement No. 101034413"
article_number: P2.24
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Patryk
full_name: Morawski, Patryk
last_name: Morawski
- first_name: Kalina H
full_name: Petrova, Kalina H
id: 554ff4e4-f325-11ee-b0c4-a10dbd523381
last_name: Petrova
citation:
ama: Morawski P, Petrova KH. Randomly perturbed digraphs also have bounded-degree
spanning trees. Electronic Journal of Combinatorics. 2026;33(2). doi:10.37236/13316
apa: Morawski, P., & Petrova, K. H. (2026). Randomly perturbed digraphs also
have bounded-degree spanning trees. Electronic Journal of Combinatorics.
Electronic Journal of Combinatorics. https://doi.org/10.37236/13316
chicago: Morawski, Patryk, and Kalina H Petrova. “Randomly Perturbed Digraphs Also
Have Bounded-Degree Spanning Trees.” Electronic Journal of Combinatorics.
Electronic Journal of Combinatorics, 2026. https://doi.org/10.37236/13316.
ieee: P. Morawski and K. H. Petrova, “Randomly perturbed digraphs also have bounded-degree
spanning trees,” Electronic Journal of Combinatorics, vol. 33, no. 2. Electronic
Journal of Combinatorics, 2026.
ista: Morawski P, Petrova KH. 2026. Randomly perturbed digraphs also have bounded-degree
spanning trees. Electronic Journal of Combinatorics. 33(2), P2.24.
mla: Morawski, Patryk, and Kalina H. Petrova. “Randomly Perturbed Digraphs Also
Have Bounded-Degree Spanning Trees.” Electronic Journal of Combinatorics,
vol. 33, no. 2, P2.24, Electronic Journal of Combinatorics, 2026, doi:10.37236/13316.
short: P. Morawski, K.H. Petrova, Electronic Journal of Combinatorics 33 (2026).
corr_author: '1'
date_created: 2026-05-17T22:02:11Z
date_published: 2026-05-08T00:00:00Z
date_updated: 2026-05-18T08:50:18Z
day: '08'
ddc:
- '510'
department:
- _id: MaKw
doi: 10.37236/13316
ec_funded: 1
external_id:
arxiv:
- '2306.14648'
file:
- access_level: open_access
checksum: 9e8402cb2e8870ba7ded9ae7b308201a
content_type: application/pdf
creator: dernst
date_created: 2026-05-18T08:46:26Z
date_updated: 2026-05-18T08:46:26Z
file_id: '21893'
file_name: 2026_ElectrJournCombinatorics_Morawski.pdf
file_size: 399969
relation: main_file
success: 1
file_date_updated: 2026-05-18T08:46:26Z
has_accepted_license: '1'
intvolume: ' 33'
issue: '2'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nd/4.0/
month: '05'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: Electronic Journal of Combinatorics
publication_identifier:
eissn:
- 1077-8926
publication_status: published
publisher: Electronic Journal of Combinatorics
quality_controlled: '1'
scopus_import: '1'
status: public
title: Randomly perturbed digraphs also have bounded-degree spanning trees
tmp:
image: /image/cc_by_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nd/4.0/legalcode
name: Creative Commons Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0)
short: CC BY-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '2026'
...