--- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '21753' abstract: - lang: eng text: The origin(s) of life (OoL), which has puzzled scientists for centuries, remains a major scientific challenge in the 21st century. Understanding the processes relevant to the OoL demands theoretical frameworks that can connect processes across scales, from microscopic dynamics to emergent levels of organization. While experimental studies generate a wealth of data, theoretical and computational approaches provide the structure necessary to interpret and generalize these findings. In Part 1, we examined the most widely used experimental techniques in the field. Here, we focus on the mathematical, physical, and computational techniques used to model phenomena relevant to life’s origin(s). We discuss methods ranging from quantum chemistry and molecular dynamics to chemical reaction networks, autocatalysis, and evolutionary modeling, as well as information-theoretic and phylogenetic approaches that link chemical and biological organization. We further highlight emerging trends such as synthetic biology, omics-based methods, and laboratory automation as novel points of contact for theory-experiment integration. Ultimately, we aim to provide an educational tool that can facilitate more post-disciplinary collaborations in OoL research by helping scientists understand what they can do about the problem of life’s origins, rather than telling them how to think about it. acknowledgement: This work is a collaborative effort of the titled authors as part of the Origin of Life Early Career Network (OoLEN). We chose to add OoLEN as the first author to give a better representation of this team effort, rather than listing any single author as the first author. We hope such a thing can be adopted by others. We indicate that authors 2–9 (S.A., C.B., C. Blanco, D.B., A.C.-R., C.M., O.M., Z.P., and A.V.D.) have made a more distinct contribution. All authors are listed alphabetically by their last names. We would like to acknowledge all current and past members of OoLEN for their contributions to our community. In particular, we would like to acknowledge Evrim Fer, who helped with molecular phylogenetics. We would like to thank the anonymous referees for reviewing Parts 1 and 2 of this manuscript; this work was significantly improved through their feedback. S.A. acknowledges support from NASA through the postdoctoral Program at GSFC. C. Bautista acknowledges support from “la Caixa” Foundation (ID 100010434) under agreement (LCF/BQ/AA16/11580051) and by the Fonds de recherche du Québec Nature et technologies (FRQNT) (#274987). C. Blanco acknowledges support from NASA under award 80NSSC21K0595. D.B. acknowledges support from Centre national d'études spatiales (CNES) and postdoctoral support from LGPM-CentralSupélec and NASA under award 80NSSC23K1477. E. Camprubi acknowledges support from UT System for a STARs award. A.C.-R. acknowledges funding from the Natural Sciences and Engineering Research Council of Canada (grant number RGPIN/05278–2018), the Fonds de recherche Nature et Technologies of Québec (grant number 314488), and the Fondation J. Armand Bombardier Excellence Scholarship. A.C.-R.’s research was supported by an appointment to the NASA Postdoctoral Program from the NASA Astrobiology Program administered by Oak Ridge Associated Universities under contract with NASA. S.F.J. acknowledges support from “la Caixa” Foundation (ID 100010434) and from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska Curie grant agreement no. 847648 (the fellowship code is LCF/BQ/PI21/11830015). T.Z.J. acknowledges support from Japan Society for the Promotion of Science (JSPS) grants-in-aid 18K14354 and 21K14746, a Tokyo Institute of Technology Yoshinori Ohsumi Fund for Fundamental Research, the Mizuho Foundation for the Promotion of Sciences, and by the Temporary Assistant Program by the DE&I Section of Science Tokyo. A.K. acknowledges support from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant agreement no. 101068029. C.M. acknowledges support from NASA through the postdoctoral Fellowship Program. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of NASA. O.M. acknowledges support from The John Templeton Foundation (#62828) and the Foundation for Science and Technology (2023.05971.CEECIND). B.K.D.P. acknowledges support from the NSERC Banting Postdoctoral Fellowship. K.P. acknowledges financial support from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy EXC 2181/1 - 390900948 (the Heidelberg STRUCTURES Excellence Cluster) and is a fellow of the International Max Planck Research School for Astronomy and Cosmic Physics at the University of Heidelberg (IMPRS-HD). article_number: '103211' article_processing_charge: Yes article_type: original author: - first_name: Silke full_name: Asche, Silke last_name: Asche - first_name: Carla full_name: Bautista, Carla last_name: Bautista - first_name: Celia full_name: Blanco, Celia last_name: Blanco - first_name: David full_name: Boulesteix, David last_name: Boulesteix - first_name: Alexandre full_name: Champagne-Ruel, Alexandre last_name: Champagne-Ruel - first_name: Cole full_name: Mathis, Cole last_name: Mathis - first_name: Omer full_name: Markovitch, Omer last_name: Markovitch - first_name: Zhen full_name: Peng, Zhen last_name: Peng - first_name: Avinash Vicholous full_name: Dass, Avinash Vicholous last_name: Dass - first_name: Alyssa full_name: Adams, Alyssa last_name: Adams - first_name: Eloi full_name: Camprubi, Eloi last_name: Camprubi - first_name: Enrico Sandro full_name: Colizzi, Enrico Sandro last_name: Colizzi - first_name: Stephanie full_name: Colón-Santos, Stephanie last_name: Colón-Santos - first_name: Hannah full_name: Dromiack, Hannah last_name: Dromiack - first_name: Valentina full_name: Erastova, Valentina last_name: Erastova - first_name: Amanda full_name: Garcia, Amanda last_name: Garcia - first_name: Ghjuvan full_name: Grimaud, Ghjuvan last_name: Grimaud - first_name: Aaron full_name: Halpern, Aaron last_name: Halpern - first_name: Stuart A. full_name: Harrison, Stuart A. last_name: Harrison - first_name: Seán F. full_name: Jordan, Seán F. last_name: Jordan - first_name: Tony Z. full_name: Jia, Tony Z. last_name: Jia - first_name: Amit full_name: Kahana, Amit last_name: Kahana - first_name: Artemy full_name: Kolchinsky, Artemy last_name: Kolchinsky - first_name: Odin full_name: Moron-Garcia, Odin last_name: Moron-Garcia - first_name: Ryo full_name: Mizuuchi, Ryo last_name: Mizuuchi - first_name: Jingbo full_name: Nan, Jingbo last_name: 'Nan' - first_name: Yuliia full_name: Orlova, Yuliia last_name: Orlova - first_name: Ben K.D. full_name: Pearce, Ben K.D. last_name: Pearce - first_name: Klaus full_name: Paschek, Klaus last_name: Paschek - first_name: Martina full_name: Preiner, Martina last_name: Preiner - first_name: Silvana full_name: Pinna, Silvana last_name: Pinna - first_name: Eduardo full_name: Rodríguez-Román, Eduardo last_name: Rodríguez-Román - first_name: Loraine full_name: Schwander, Loraine last_name: Schwander - first_name: Siddhant full_name: Sharma, Siddhant id: 36996868-4916-11f1-8c9d-c0c901467b61 last_name: Sharma - first_name: Harrison B. full_name: Smith, Harrison B. last_name: Smith - first_name: Andrey full_name: Vieira, Andrey last_name: Vieira - first_name: Joana C. full_name: Xavier, Joana C. last_name: Xavier citation: ama: 'Asche S, Bautista C, Blanco C, et al. What it takes to solve the origins of life: An integrated review. Part 2: Theoretical methods and emerging trends. Cell Reports Physical Science. 2026;7(4). doi:10.1016/j.xcrp.2026.103211' apa: 'Asche, S., Bautista, C., Blanco, C., Boulesteix, D., Champagne-Ruel, A., Mathis, C., … Xavier, J. C. (2026). What it takes to solve the origins of life: An integrated review. Part 2: Theoretical methods and emerging trends. Cell Reports Physical Science. Elsevier. https://doi.org/10.1016/j.xcrp.2026.103211' chicago: 'Asche, Silke, Carla Bautista, Celia Blanco, David Boulesteix, Alexandre Champagne-Ruel, Cole Mathis, Omer Markovitch, et al. “What It Takes to Solve the Origins of Life: An Integrated Review. Part 2: Theoretical Methods and Emerging Trends.” Cell Reports Physical Science. Elsevier, 2026. https://doi.org/10.1016/j.xcrp.2026.103211.' ieee: 'S. Asche et al., “What it takes to solve the origins of life: An integrated review. Part 2: Theoretical methods and emerging trends,” Cell Reports Physical Science, vol. 7, no. 4. Elsevier, 2026.' ista: 'Asche S, Bautista C, Blanco C, Boulesteix D, Champagne-Ruel A, Mathis C, Markovitch O, Peng Z, Dass AV, Adams A, Camprubi E, Colizzi ES, Colón-Santos S, Dromiack H, Erastova V, Garcia A, Grimaud G, Halpern A, Harrison SA, Jordan SF, Jia TZ, Kahana A, Kolchinsky A, Moron-Garcia O, Mizuuchi R, Nan J, Orlova Y, Pearce BKD, Paschek K, Preiner M, Pinna S, Rodríguez-Román E, Schwander L, Sharma S, Smith HB, Vieira A, Xavier JC. 2026. What it takes to solve the origins of life: An integrated review. Part 2: Theoretical methods and emerging trends. Cell Reports Physical Science. 7(4), 103211.' mla: 'Asche, Silke, et al. “What It Takes to Solve the Origins of Life: An Integrated Review. Part 2: Theoretical Methods and Emerging Trends.” Cell Reports Physical Science, vol. 7, no. 4, 103211, Elsevier, 2026, doi:10.1016/j.xcrp.2026.103211.' short: S. Asche, C. Bautista, C. Blanco, D. Boulesteix, A. Champagne-Ruel, C. Mathis, O. Markovitch, Z. Peng, A.V. Dass, A. Adams, E. Camprubi, E.S. Colizzi, S. Colón-Santos, H. Dromiack, V. Erastova, A. Garcia, G. Grimaud, A. Halpern, S.A. Harrison, S.F. Jordan, T.Z. Jia, A. Kahana, A. Kolchinsky, O. Moron-Garcia, R. Mizuuchi, J. Nan, Y. Orlova, B.K.D. Pearce, K. Paschek, M. Preiner, S. Pinna, E. Rodríguez-Román, L. Schwander, S. Sharma, H.B. Smith, A. Vieira, J.C. Xavier, Cell Reports Physical Science 7 (2026). date_created: 2026-04-19T22:07:50Z date_published: 2026-04-15T00:00:00Z date_updated: 2026-05-07T12:13:07Z day: '15' ddc: - '570' doi: 10.1016/j.xcrp.2026.103211 file: - access_level: open_access checksum: d5abe5b5bd4b9ee58aa6f4917f688ad9 content_type: application/pdf creator: dernst date_created: 2026-05-06T06:48:33Z date_updated: 2026-05-06T06:48:33Z file_id: '21804' file_name: 2026_CellReports_OoLEN.pdf file_size: 5265320 relation: main_file success: 1 file_date_updated: 2026-05-06T06:48:33Z has_accepted_license: '1' intvolume: ' 7' issue: '4' language: - iso: eng month: '04' oa: 1 oa_version: Published Version publication: Cell Reports Physical Science publication_identifier: eissn: - 2666-3864 publication_status: published publisher: Elsevier quality_controlled: '1' scopus_import: '1' status: public title: 'What it takes to solve the origins of life: An integrated review. Part 2: Theoretical methods and emerging trends' tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 7 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '21754' abstract: - lang: eng text: The origin(s) of life (OoL), which has puzzled scientists for centuries, remains a major scientific challenge in the 21st century. Research on OoL spans many disciplines, including chemistry, physics, biology, planetary sciences, computer science, and mathematics. The sheer number of different scientific perspectives relevant to the problem has resulted in the coexistence of diverse tools, techniques, data, and software in OoL studies. This has made communication between the disciplines relevant to the OoL extremely difficult because the interpretation of data, analyses, or standards of evidence varies dramatically. Here, we hope to bridge this wide field of study by providing common ground via the consolidation of techniques rather than positing a unifying view on how life emerges. In part 1 of this review, we cover common experimental techniques that have been used significantly in OoL studies in recent years, while in part 2, we review theoretical, computational, and integrative methods. Here, we discuss the use of spectroscopy, spectrometry, chromatography, microscopy, and sequencing methods for characterizing diverse materials. We further discuss the role of data repositories in facilitating the analysis and dissemination of experimental data. This review provides a baseline expectation and understanding of the analytical aspects of origins’ research. Ultimately, we aim to provide an educational tool that can facilitate more post-disciplinary collaborations in OoL research by helping scientists understand what they can do about the problem of life’s origins, rather than telling them how to think about it. acknowledgement: This work is a collaborative effort of the titled authors as part of the Origin of Life Early Career Network (OoLEN). We chose to add OoLEN as the first author to give a better representation of this team effort, rather than listing any single author as the first author. We hope such a thing can be adopted by others. We indicate that authors 2–9 (S.A., C.B., C. Blanco, D.B., A.C.-R., C.M., O.M., Z.P., and A.V.D.) have made a more distinct contribution. All authors are listed alphabetically by their last names. We would like to acknowledge all current and past members of OoLEN for their contributions to our community. In particular, we would like to acknowledge Evrim Fer, who helped with molecular phylogenetics. We would like to thank the anonymous referees for reviewing Parts 1 and 2 of this manuscript; this work was significantly improved through their feedback. S.A. acknowledges support from NASA through the postdoctoral Program at GSFC. C. Bautista acknowledges support from “la Caixa” Foundation (ID 100010434) under agreement (LCF/BQ/AA16/11580051) and by the Fonds de recherche du Québec Nature et technologies (FRQNT) (#274987). C. Blanco acknowledges support from NASA under award 80NSSC21K0595. D.B. acknowledges support from Centre national d'études spatiales (CNES) and postdoctoral support from LGPM-CentralSupélec and NASA under award 80NSSC23K1477. E. Camprubi acknowledges support from UT System for a STARs award. A.C.-R. acknowledges funding from the Natural Sciences and Engineering Research Council of Canada (grant number RGPIN/05278–2018), the Fonds de recherche Nature et Technologies of Québec (grant number 314488), and the Fondation J. Armand Bombardier Excellence Scholarship. A.C.-R.’s research was supported by an appointment to the NASA Postdoctoral Program from the NASA Astrobiology Program administered by Oak Ridge Associated Universities under contract with NASA. S.F.J. acknowledges support from “la Caixa” Foundation (ID 100010434) and from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska Curie grant agreement no. 847648 (the fellowship code is LCF/BQ/PI21/11830015). T.Z.J. acknowledges support from Japan Society for the Promotion of Science (JSPS) grants-in-aid 18K14354 and 21K14746, a Tokyo Institute of Technology Yoshinori Ohsumi Fund for Fundamental Research, the Mizuho Foundation for the Promotion of Sciences, and by the Temporary Assistant Program by the DE&I Section of Science Tokyo. A.K. acknowledges support from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant agreement no. 101068029. C.M. acknowledges support from NASA through the postdoctoral Fellowship Program. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of NASA. O.M. acknowledges support from The John Templeton Foundation (#62828) and the Foundation for Science and Technology (2023.05971.CEECIND). B.K.D.P. acknowledges support from the NSERC Banting Postdoctoral Fellowship. K.P. acknowledges financial support from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy EXC 2181/1 - 390900948 (the Heidelberg STRUCTURES Excellence Cluster) and is a fellow of the International Max Planck Research School for Astronomy and Cosmic Physics at the University of Heidelberg (IMPRS-HD). article_number: '103212' article_processing_charge: Yes article_type: original author: - first_name: Silke full_name: Asche, Silke last_name: Asche - first_name: Carla full_name: Bautista, Carla last_name: Bautista - first_name: Celia full_name: Blanco, Celia last_name: Blanco - first_name: David full_name: Boulesteix, David last_name: Boulesteix - first_name: Alexandre full_name: Champagne-Ruel, Alexandre last_name: Champagne-Ruel - first_name: Cole full_name: Mathis, Cole last_name: Mathis - first_name: Omer full_name: Markovitch, Omer last_name: Markovitch - first_name: Zhen full_name: Peng, Zhen last_name: Peng - first_name: Avinash Vicholous full_name: Dass, Avinash Vicholous last_name: Dass - first_name: Alyssa full_name: Adams, Alyssa last_name: Adams - first_name: Eloi full_name: Camprubi, Eloi last_name: Camprubi - first_name: Enrico Sandro full_name: Colizzi, Enrico Sandro last_name: Colizzi - first_name: Stephanie full_name: Colón-Santos, Stephanie last_name: Colón-Santos - first_name: Hannah full_name: Dromiack, Hannah last_name: Dromiack - first_name: Valentina full_name: Erastova, Valentina last_name: Erastova - first_name: Amanda full_name: Garcia, Amanda last_name: Garcia - first_name: Ghjuvan full_name: Grimaud, Ghjuvan last_name: Grimaud - first_name: Aaron full_name: Halpern, Aaron last_name: Halpern - first_name: Stuart A. full_name: Harrison, Stuart A. last_name: Harrison - first_name: Seán F. full_name: Jordan, Seán F. last_name: Jordan - first_name: Tony Z. full_name: Jia, Tony Z. last_name: Jia - first_name: Amit full_name: Kahana, Amit last_name: Kahana - first_name: Artemy full_name: Kolchinsky, Artemy last_name: Kolchinsky - first_name: Odin full_name: Moron-Garcia, Odin last_name: Moron-Garcia - first_name: Ryo full_name: Mizuuchi, Ryo last_name: Mizuuchi - first_name: Jingbo full_name: Nan, Jingbo last_name: 'Nan' - first_name: Yuliia full_name: Orlova, Yuliia last_name: Orlova - first_name: Ben K.D. full_name: Pearce, Ben K.D. last_name: Pearce - first_name: Klaus full_name: Paschek, Klaus last_name: Paschek - first_name: Martina full_name: Preiner, Martina last_name: Preiner - first_name: Silvana full_name: Pinna, Silvana last_name: Pinna - first_name: Eduardo full_name: Rodríguez-Román, Eduardo last_name: Rodríguez-Román - first_name: Loraine full_name: Schwander, Loraine last_name: Schwander - first_name: Siddhant full_name: Sharma, Siddhant id: 36996868-4916-11f1-8c9d-c0c901467b61 last_name: Sharma - first_name: Harrison B. full_name: Smith, Harrison B. last_name: Smith - first_name: Andrey full_name: Vieira, Andrey last_name: Vieira - first_name: Joana C. full_name: Xavier, Joana C. last_name: Xavier citation: ama: 'Asche S, Bautista C, Blanco C, et al. What it takes to solve the origin of life: An integrated review. Part 1–Experimental methods and data repositories. Cell Reports Physical Science. 2026;7(4). doi:10.1016/j.xcrp.2026.103212' apa: 'Asche, S., Bautista, C., Blanco, C., Boulesteix, D., Champagne-Ruel, A., Mathis, C., … Xavier, J. C. (2026). What it takes to solve the origin of life: An integrated review. Part 1–Experimental methods and data repositories. Cell Reports Physical Science. Elsevier. https://doi.org/10.1016/j.xcrp.2026.103212' chicago: 'Asche, Silke, Carla Bautista, Celia Blanco, David Boulesteix, Alexandre Champagne-Ruel, Cole Mathis, Omer Markovitch, et al. “What It Takes to Solve the Origin of Life: An Integrated Review. Part 1–Experimental Methods and Data Repositories.” Cell Reports Physical Science. Elsevier, 2026. https://doi.org/10.1016/j.xcrp.2026.103212.' ieee: 'S. Asche et al., “What it takes to solve the origin of life: An integrated review. Part 1–Experimental methods and data repositories,” Cell Reports Physical Science, vol. 7, no. 4. Elsevier, 2026.' ista: 'Asche S, Bautista C, Blanco C, Boulesteix D, Champagne-Ruel A, Mathis C, Markovitch O, Peng Z, Dass AV, Adams A, Camprubi E, Colizzi ES, Colón-Santos S, Dromiack H, Erastova V, Garcia A, Grimaud G, Halpern A, Harrison SA, Jordan SF, Jia TZ, Kahana A, Kolchinsky A, Moron-Garcia O, Mizuuchi R, Nan J, Orlova Y, Pearce BKD, Paschek K, Preiner M, Pinna S, Rodríguez-Román E, Schwander L, Sharma S, Smith HB, Vieira A, Xavier JC. 2026. What it takes to solve the origin of life: An integrated review. Part 1–Experimental methods and data repositories. Cell Reports Physical Science. 7(4), 103212.' mla: 'Asche, Silke, et al. “What It Takes to Solve the Origin of Life: An Integrated Review. Part 1–Experimental Methods and Data Repositories.” Cell Reports Physical Science, vol. 7, no. 4, 103212, Elsevier, 2026, doi:10.1016/j.xcrp.2026.103212.' short: S. Asche, C. Bautista, C. Blanco, D. Boulesteix, A. Champagne-Ruel, C. Mathis, O. Markovitch, Z. Peng, A.V. Dass, A. Adams, E. Camprubi, E.S. Colizzi, S. Colón-Santos, H. Dromiack, V. Erastova, A. Garcia, G. Grimaud, A. Halpern, S.A. Harrison, S.F. Jordan, T.Z. Jia, A. Kahana, A. Kolchinsky, O. Moron-Garcia, R. Mizuuchi, J. Nan, Y. Orlova, B.K.D. Pearce, K. Paschek, M. Preiner, S. Pinna, E. Rodríguez-Román, L. Schwander, S. Sharma, H.B. Smith, A. Vieira, J.C. Xavier, Cell Reports Physical Science 7 (2026). date_created: 2026-04-19T22:07:52Z date_published: 2026-04-15T00:00:00Z date_updated: 2026-05-07T12:13:25Z day: '15' ddc: - '570' doi: 10.1016/j.xcrp.2026.103212 file: - access_level: open_access checksum: e580d22c2874c0afcbde2d167db7201b content_type: application/pdf creator: dernst date_created: 2026-05-07T05:48:23Z date_updated: 2026-05-07T05:48:23Z file_id: '21831' file_name: 2026_CellREports_OoLEN1.pdf file_size: 3535247 relation: main_file success: 1 file_date_updated: 2026-05-07T05:48:23Z has_accepted_license: '1' intvolume: ' 7' issue: '4' language: - iso: eng month: '04' oa: 1 oa_version: Published Version publication: Cell Reports Physical Science publication_identifier: eissn: - 2666-3864 publication_status: published publisher: Elsevier quality_controlled: '1' scopus_import: '1' status: public title: 'What it takes to solve the origin of life: An integrated review. Part 1–Experimental methods and data repositories' tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 7 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '21755' abstract: - lang: eng text: Tropical shallow clouds are a major source of uncertainty in Earth's climate sensitivity, especially through their spatial arrangement, which global climate models do not represent. Efforts to understand their organization have partly relied on classifying observed scenes, identifying four patterns as archetypal regimes. Here we analyze geostationary satellite imagery of the western tropical Atlantic using the L‐function, a tool based on point pattern theory that quantifies cloud organization across spatial scales. Classical examples of the four patterns show distinct L‐function fingerprints, revealing their characteristic clustering and regularity scales and aiding physical interpretation. Yet, when evaluating many scenes at fixed spatial scales, the L‐function distribution lacks the distinct modes expected from discrete regimes. This is corroborated by analyses of other organization indices employing diverse approaches, from inter‐cloud nearest‐neighbor distances to fractal analysis. Implications for the parameterization of mesoscale cloud organization in climate models are discussed. acknowledgement: GB was supported by an ICTP Postdoctoral Research Fellowship Agreement. GM was supported by the CNRS. AC was supported by the European Union's Horizon 2020 research and innovation programme Marie Sklodowska-Curie Grant agreement No 101034413. LJF acknowledges funding from the NERC Doctoral Training Partnership in Environmental Research Grant NE/S007474/1. We thank three anonymous reviewers and Jiawei Bao for their insightful comments, which greatly improved this manuscript. article_number: e2025GL119921 article_processing_charge: Yes article_type: original author: - first_name: Giovanni full_name: Biagioli, Giovanni last_name: Biagioli - first_name: Giulio full_name: Mandorli, Giulio last_name: Mandorli - first_name: Lilli Johanna full_name: Freischem, Lilli Johanna last_name: Freischem - first_name: Alejandro full_name: Casallas Garcia, Alejandro id: 92081129-2d75-11ef-a48d-b04dd7a2385a last_name: Casallas Garcia orcid: 0000-0002-1988-5035 - first_name: Adrian Mark full_name: Tompkins, Adrian Mark last_name: Tompkins citation: ama: 'Biagioli G, Mandorli G, Freischem LJ, Casallas Garcia A, Tompkins AM. Spatial patterns of shallow clouds: Challenging the concept of defined regimes. Geophysical Research Letters. 2026;53(8). doi:10.1029/2025gl119921' apa: 'Biagioli, G., Mandorli, G., Freischem, L. J., Casallas Garcia, A., & Tompkins, A. M. (2026). Spatial patterns of shallow clouds: Challenging the concept of defined regimes. Geophysical Research Letters. Wiley. https://doi.org/10.1029/2025gl119921' chicago: 'Biagioli, Giovanni, Giulio Mandorli, Lilli Johanna Freischem, Alejandro Casallas Garcia, and Adrian Mark Tompkins. “Spatial Patterns of Shallow Clouds: Challenging the Concept of Defined Regimes.” Geophysical Research Letters. Wiley, 2026. https://doi.org/10.1029/2025gl119921.' ieee: 'G. Biagioli, G. Mandorli, L. J. Freischem, A. Casallas Garcia, and A. M. Tompkins, “Spatial patterns of shallow clouds: Challenging the concept of defined regimes,” Geophysical Research Letters, vol. 53, no. 8. Wiley, 2026.' ista: 'Biagioli G, Mandorli G, Freischem LJ, Casallas Garcia A, Tompkins AM. 2026. Spatial patterns of shallow clouds: Challenging the concept of defined regimes. Geophysical Research Letters. 53(8), e2025GL119921.' mla: 'Biagioli, Giovanni, et al. “Spatial Patterns of Shallow Clouds: Challenging the Concept of Defined Regimes.” Geophysical Research Letters, vol. 53, no. 8, e2025GL119921, Wiley, 2026, doi:10.1029/2025gl119921.' short: G. Biagioli, G. Mandorli, L.J. Freischem, A. Casallas Garcia, A.M. Tompkins, Geophysical Research Letters 53 (2026). date_created: 2026-04-21T06:04:41Z date_published: 2026-04-28T00:00:00Z date_updated: 2026-04-28T13:35:53Z day: '28' ddc: - '550' department: - _id: CaMu doi: 10.1029/2025gl119921 ec_funded: 1 file: - access_level: open_access checksum: 2cd4ae120b14b244f5b2f50eaae0efc1 content_type: application/pdf creator: acasalla date_created: 2026-04-21T06:07:22Z date_updated: 2026-04-21T06:07:22Z file_id: '21756' file_name: Gio_Casallas_2026.pdf file_size: 1544417 relation: main_file success: 1 file_date_updated: 2026-04-21T06:07:22Z has_accepted_license: '1' intvolume: ' 53' issue: '8' language: - iso: eng month: '04' oa: 1 oa_version: Published Version project: - _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c call_identifier: H2020 grant_number: '101034413' name: 'IST-BRIDGE: International postdoctoral program' publication: Geophysical Research Letters publication_identifier: eissn: - 1944-8007 issn: - 0094-8276 publication_status: published publisher: Wiley quality_controlled: '1' scopus_import: '1' status: public title: 'Spatial patterns of shallow clouds: Challenging the concept of defined regimes' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 53 year: '2026' ... --- OA_place: publisher OA_type: hybrid _id: '21759' abstract: - lang: eng text: 'Promoters and enhancers are cis-regulatory elements (CREs), DNA sequences that bind transcription factor (TF) proteins to up- or down-regulate target genes. Decades-long efforts yielded TF-DNA interaction models that predict how strongly an individual TF binds arbitrary DNA sequences and how individual binding events on the CRE combine to affect gene expression. These insights can be synthesized into a global, biophysically realistic, and quantitative genotype-phenotype (GP) map for gene regulation, a ‘holy grail’ for the application of evolutionary theory. A global map provides a rare opportunity to simulate the long-term evolution of regulatory sequences and pose several fundamental questions: How long does it take to evolve CREs de novo? How many non-trivial regulatory functions exist in sequence space? How connected are they? For which regulatory architecture is CRE evolution most rapid and evolvable? In this article, the second of a two-part series, we review the application of evolutionary concepts — epistasis, robustness, evolvability, tunability, plasticity, and bet-hedging — to the evolution of gene regulatory sequences. We then evaluate the potential for a unifying theory for the evolution of regulatory sequences and identify key open challenges.' acknowledgement: "We thank Calin Guet and Santiago Herrera-Álvarez for essential contributions to this manuscript.\r\nE.M. acknowledges support from the APART-USA fellowship, jointly funded by the Austrian Academy of Sciences (ÖAW) and the Institute of Science and Technology Austria (ISTA). N.B. acknowledges funding from the ERC Advanced Grant 101055327 “HaplotypeStructure”.\r\nThis study was also supported by the European Molecular Biology Laboratory (N.O.B., J.C.)." article_number: '102472' article_processing_charge: Yes (via OA deal) article_type: review author: - first_name: Elia full_name: Mascolo, Elia id: 776a6ed0-a053-11f0-8635-80b95e0e0d53 last_name: Mascolo orcid: 0000-0003-2977-7844 - first_name: Reka E full_name: Körei, Reka E id: 50FDE43E-AA30-11E9-A72B-8A12E6697425 last_name: Körei - first_name: Noa O. full_name: Borst, Noa O. last_name: Borst - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 - first_name: Justin full_name: Crocker, Justin last_name: Crocker - first_name: Gašper full_name: Tkačik, Gašper id: 3D494DCA-F248-11E8-B48F-1D18A9856A87 last_name: Tkačik orcid: 0000-0002-6699-1455 citation: ama: 'Mascolo E, Körei RE, Borst NO, Barton NH, Crocker J, Tkačik G. Long-term evolution of regulatory DNA sequences. Part 2: Theory and future challenges. Current Opinion in Genetics and Development. 2026;98. doi:10.1016/j.gde.2026.102472' apa: 'Mascolo, E., Körei, R. E., Borst, N. O., Barton, N. H., Crocker, J., & Tkačik, G. (2026). Long-term evolution of regulatory DNA sequences. Part 2: Theory and future challenges. Current Opinion in Genetics and Development. Elsevier. https://doi.org/10.1016/j.gde.2026.102472' chicago: 'Mascolo, Elia, Reka E Körei, Noa O. Borst, Nicholas H Barton, Justin Crocker, and Gašper Tkačik. “Long-Term Evolution of Regulatory DNA Sequences. Part 2: Theory and Future Challenges.” Current Opinion in Genetics and Development. Elsevier, 2026. https://doi.org/10.1016/j.gde.2026.102472.' ieee: 'E. Mascolo, R. E. Körei, N. O. Borst, N. H. Barton, J. Crocker, and G. Tkačik, “Long-term evolution of regulatory DNA sequences. Part 2: Theory and future challenges,” Current Opinion in Genetics and Development, vol. 98. Elsevier, 2026.' ista: 'Mascolo E, Körei RE, Borst NO, Barton NH, Crocker J, Tkačik G. 2026. Long-term evolution of regulatory DNA sequences. Part 2: Theory and future challenges. Current Opinion in Genetics and Development. 98, 102472.' mla: 'Mascolo, Elia, et al. “Long-Term Evolution of Regulatory DNA Sequences. Part 2: Theory and Future Challenges.” Current Opinion in Genetics and Development, vol. 98, 102472, Elsevier, 2026, doi:10.1016/j.gde.2026.102472.' short: E. Mascolo, R.E. Körei, N.O. Borst, N.H. Barton, J. Crocker, G. Tkačik, Current Opinion in Genetics and Development 98 (2026). corr_author: '1' date_created: 2026-04-26T22:01:46Z date_published: 2026-04-15T00:00:00Z date_updated: 2026-06-18T08:34:09Z day: '15' ddc: - '570' department: - _id: GaTk - _id: NiBa doi: 10.1016/j.gde.2026.102472 intvolume: ' 98' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1016/j.gde.2026.102472 month: '04' oa: 1 oa_version: Published Version project: - _id: bd6958e0-d553-11ed-ba76-86eba6a76c00 grant_number: '101055327' name: Understanding the evolution of continuous genomes publication: Current Opinion in Genetics and Development publication_identifier: eissn: - 1879-0380 issn: - 0959-437X publication_status: epub_ahead publisher: Elsevier quality_controlled: '1' scopus_import: '1' status: public title: 'Long-term evolution of regulatory DNA sequences. Part 2: Theory and future challenges' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 98 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '21760' abstract: - lang: eng text: 3I/ATLAS is the third interstellar object discovered to date, following 1I/‘Oumuamua and 2I/Borisov. Its unusually high excess velocity and active cometary nature make it a key probe of the Galactic population of icy planetesimals. Understanding its origin requires its past trajectory through the Galaxy to be traced and the possible role of stellar encounters to be assessed, both as a potential origin and a perturber to its orbit. We integrated the orbit of 3I/ATLAS backward in time for 10 Myr, together with a sample of Gaia DR3 stars with high-quality astrometry and radial velocities, to identify close passages within 2 pc. We identify 93 nominal encounters, 62 of which are significant at the 2σ level. However, none of these encounters produced any meaningful perturbation. The strongest perturber Gaia DR3 6863591389529611264 at 0.30 pc and with a relative velocity of 35 km s−1, imparted only a velocity change of ∣Δv∣ ≃ 5 × 10−4 km s−1 to the orbit of 3I/ATLAS. Our results indicate that no stellar flybys within the past 10 Myr and 500 pc contained in Gaia DR3 can account for the present trajectory of 3I/ATLAS or be associated with its origin. We further show that 3I/ATLAS is kinematically consistent with a thin-disk population, despite its large peculiar velocity. acknowledgement: We thank the anonymous referee for a careful reading of the manuscript and for constructive comments that improved the paper. X.P.C. and S.T. thank J.L. Gragera-Más and Ylva Götberg for their valuable feedback and comments. X.P.C. acknowledges financial support from the Spanish National Programme for the Promotion of Talent and its Employability grant PRE2022-104959 cofunded by the European Social Fund. S.T. acknowledges the funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 101034413. E.V. acknowledges support from the DISCOBOLO project funded by the Spanish Ministerio de Ciencia, Innovación y Universidades under grant PID2021-127289NB-I00. A.J.M. acknowledges support from the Swedish National Space Agency (Career grant 2023-00146). X.P.C. and M.M. acknowledge support from the Spanish Ministerio de Ciencia, Innovaciòn y Universidades under grants PID2021122842OB-C22 and PID2024-157964OB-C22; from the Xunta de Galicia and the European Union (FEDER Galicia 2021-2027 Program) Ref. ED431B 2024/21, ED431B 2024/02, and CITIC ED431G 2023/01. This work has made use of data from the European Space Agency (ESA) Gaia mission and processed by the Gaia Data Processing and Analysis Consortium (DPAC). Funding for the DPAC has been provided by national institutions, particularly the institutions participating in the Gaia Multilateral Agreement. article_number: '146' article_processing_charge: Yes article_type: original arxiv: 1 author: - first_name: X. full_name: Pérez-Couto, X. last_name: Pérez-Couto - first_name: Santiago full_name: Torres Rodriguez, Santiago id: a8df4360-4328-11ee-8f1a-e502d0c83fc2 last_name: Torres Rodriguez orcid: 0000-0002-3150-8988 - first_name: E. full_name: Villaver, E. last_name: Villaver - first_name: A. J. full_name: Mustill, A. J. last_name: Mustill - first_name: M. full_name: Manteiga, M. last_name: Manteiga citation: ama: 'Pérez-Couto X, Torres Rodriguez S, Villaver E, Mustill AJ, Manteiga M. 3I/ATLAS: In search of the witnesses to its voyage. The Astrophysical Journal. 2026;1001(2). doi:10.3847/1538-4357/ae56ff' apa: 'Pérez-Couto, X., Torres Rodriguez, S., Villaver, E., Mustill, A. J., & Manteiga, M. (2026). 3I/ATLAS: In search of the witnesses to its voyage. The Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ae56ff' chicago: 'Pérez-Couto, X., Santiago Torres Rodriguez, E. Villaver, A. J. Mustill, and M. Manteiga. “3I/ATLAS: In Search of the Witnesses to Its Voyage.” The Astrophysical Journal. IOP Publishing, 2026. https://doi.org/10.3847/1538-4357/ae56ff.' ieee: 'X. Pérez-Couto, S. Torres Rodriguez, E. Villaver, A. J. Mustill, and M. Manteiga, “3I/ATLAS: In search of the witnesses to its voyage,” The Astrophysical Journal, vol. 1001, no. 2. IOP Publishing, 2026.' ista: 'Pérez-Couto X, Torres Rodriguez S, Villaver E, Mustill AJ, Manteiga M. 2026. 3I/ATLAS: In search of the witnesses to its voyage. The Astrophysical Journal. 1001(2), 146.' mla: 'Pérez-Couto, X., et al. “3I/ATLAS: In Search of the Witnesses to Its Voyage.” The Astrophysical Journal, vol. 1001, no. 2, 146, IOP Publishing, 2026, doi:10.3847/1538-4357/ae56ff.' short: X. Pérez-Couto, S. Torres Rodriguez, E. Villaver, A.J. Mustill, M. Manteiga, The Astrophysical Journal 1001 (2026). date_created: 2026-04-26T22:01:46Z date_published: 2026-04-20T00:00:00Z date_updated: 2026-04-28T13:08:39Z day: '20' ddc: - '520' department: - _id: LiBu doi: 10.3847/1538-4357/ae56ff ec_funded: 1 external_id: arxiv: - '2509.07678' file: - access_level: open_access checksum: c3daf49261a9933c079854c38eec316f content_type: application/pdf creator: dernst date_created: 2026-04-28T13:06:00Z date_updated: 2026-04-28T13:06:00Z file_id: '21773' file_name: 2026_AstrophysicalJournal_PerezCouto.pdf file_size: 2905627 relation: main_file success: 1 file_date_updated: 2026-04-28T13:06:00Z has_accepted_license: '1' intvolume: ' 1001' issue: '2' language: - iso: eng month: '04' oa: 1 oa_version: Published Version project: - _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c call_identifier: H2020 grant_number: '101034413' name: 'IST-BRIDGE: International postdoctoral program' publication: The Astrophysical Journal publication_identifier: eissn: - 1538-4357 issn: - 0004-637X publication_status: published publisher: IOP Publishing quality_controlled: '1' scopus_import: '1' status: public title: '3I/ATLAS: In search of the witnesses to its voyage' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 1001 year: '2026' ... --- OA_place: publisher OA_type: hybrid _id: '21761' abstract: - lang: eng text: Neural tube closure is a critical morphogenetic process in vertebrate development, and failure to close cranial regions such as the hindbrain neuropore (HNP) leads to severe congenital malformations. While mechanical forces such as actomyosin purse-string contraction and directional cell crawling have been implicated in driving HNP closure, how these forces organize local cell shape and motion to produce large-scale tissue remodeling remains poorly understood. Using live and fixed imaging of mouse embryos combined with cell-based biophysical modeling, we show that these force-generating mechanisms are insufficient to explain the reproducible patterns of cell elongation and nematic alignment observed at the HNP border. Instead, we show that local anisotropic stress and cytoskeletal organization are required to generate these patterns and promote midline cell motion. Our model captures key features of cell shape dynamics and emergent nematic order, which we confirm experimentally, including the alignment of actin fibers with cell shape and enhanced midline cell speed. Comparative analysis with chick embryos, which lack supracellular purse strings, supports a conserved link between tension generation and cellular patterning. These findings establish a physical framework connecting force generation, cell shape anisotropy, and tissue morphodynamics during epithelial gap closure. acknowledgement: S.B. acknowledges support from the National Institutes of Health (NIH R35 GM143042) and the National Science Foundation (NSF MCB-2203601). G.L.G. acknowledges support from the Wellcome Trust (211112/Z/18/Z), the Royal Society (RG\R2\232082), and the Leverhulme Trust (RPG-2024-147). E.M. acknowledges support from European Union’s Horizon 2021 Marie Sklodowska-Curie grant agreement no. 101067028. F.P.-V. acknowledges support from the NOMIS foundation. The surface subtraction macro is courtesy of Dr. Dale Moulding and available on GitHub (https://github.com/DaleMoulding/Fiji-Macros). article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Fernanda L full_name: Perez Verdugo, Fernanda L id: 4ecec223-9070-11ef-a0a9-bc76077bea8d last_name: Perez Verdugo - first_name: Eirini full_name: Maniou, Eirini last_name: Maniou - first_name: Gabriel L. full_name: Galea, Gabriel L. last_name: Galea - first_name: Shiladitya full_name: Banerjee, Shiladitya last_name: Banerjee citation: ama: Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis. Current Biology. 2026;36(8):1903-1917.e5. doi:10.1016/j.cub.2026.02.068 apa: Perez Verdugo, F. L., Maniou, E., Galea, G. L., & Banerjee, S. (2026). Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2026.02.068 chicago: Perez Verdugo, Fernanda L, Eirini Maniou, Gabriel L. Galea, and Shiladitya Banerjee. “Mechanosensitive Feedback Organizes Cell Shape and Motion during Hindbrain Neuropore Morphogenesis.” Current Biology. Elsevier, 2026. https://doi.org/10.1016/j.cub.2026.02.068. ieee: F. L. Perez Verdugo, E. Maniou, G. L. Galea, and S. Banerjee, “Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis,” Current Biology, vol. 36, no. 8. Elsevier, p. 1903–1917.e5, 2026. ista: Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. 2026. Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis. Current Biology. 36(8), 1903–1917.e5. mla: Perez Verdugo, Fernanda L., et al. “Mechanosensitive Feedback Organizes Cell Shape and Motion during Hindbrain Neuropore Morphogenesis.” Current Biology, vol. 36, no. 8, Elsevier, 2026, p. 1903–1917.e5, doi:10.1016/j.cub.2026.02.068. short: F.L. Perez Verdugo, E. Maniou, G.L. Galea, S. Banerjee, Current Biology 36 (2026) 1903–1917.e5. date_created: 2026-04-26T22:01:46Z date_published: 2026-04-20T00:00:00Z date_updated: 2026-04-28T13:15:42Z day: '20' ddc: - '570' department: - _id: AnSa doi: 10.1016/j.cub.2026.02.068 external_id: pmid: - '41881011' file: - access_level: open_access checksum: 80ae45457b4682c50c84f54de15aa9a8 content_type: application/pdf creator: dernst date_created: 2026-04-28T13:13:40Z date_updated: 2026-04-28T13:13:40Z file_id: '21774' file_name: 2026_CurrentBiology_PerezVerdugo.pdf file_size: 13402043 relation: main_file success: 1 file_date_updated: 2026-04-28T13:13:40Z has_accepted_license: '1' intvolume: ' 36' issue: '8' language: - iso: eng month: '04' oa: 1 oa_version: Published Version page: 1903-1917.e5 pmid: 1 publication: Current Biology publication_identifier: eissn: - 1879-0445 issn: - 0960-9822 publication_status: published publisher: Elsevier quality_controlled: '1' scopus_import: '1' status: public title: Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 36 year: '2026' ... --- OA_type: closed access _id: '21762' abstract: - lang: eng text: Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular organization. The plasmid-encoded ParMRC system forms actin-like filaments that segregate low–copy number plasmids. In multicellular cyanobacteria such as Anabaena sp., we found that a chromosomally encoded ParMR system has evolved into a cytoskeletal system named CorMR with a function in cell shape control rather than DNA segregation. Live-cell imaging, in vitro reconstitution, and cryo–electron microscopy revealed that CorM formed dynamically unstable, antiparallel double-stranded filaments that were recruited to the membrane by CorR through an amphipathic helix conserved in multicellular cyanobacteria. CorMR filaments were regulated by MinC, which excluded them from the poles and division plane. Comparative genomics indicated that the repurposing of ParMR and Min systems coevolved with cyanobacterial multicellularity, highlighting the evolutionary plasticity of cytoskeletal systems in bacteria. acknowledged_ssus: - _id: Bio - _id: ScienComp - _id: EM-Fac - _id: LifeSc acknowledgement: "We thank all members of the Loose lab at ISTA for helpful discussions; M. Kojic for critical reading of the manuscript; A. Herrero (Sevilla University) for sharing her extensive BACTH plasmid library and other plasmids, as well as cyanobacterial strains; T. Dagan and F. Nies (both Kiel University) for sharing cyanobacterial strains and plasmids and for valuable discussions; N. Sapay and A. Michon for providing the Amphipaseek code, which enabled us to perform our large-scale amphipathic helix screen of cyanobacterial CorR proteins; V.-V. Hodirnau for support in cryo-ET data collection; and J. Hansen for advice about cryo-EM data processing.\r\nThis work was supported by the Scientific Service Units (SSU) of ISTA through resources provided by the Imaging & Optics Facility (IOF), the Scientific Computing (SciComp), the Electron Microscopy Facility (EMF), and the Lab Support Facility (LSF). This work was funded by the European Union’s Horizon 2020 research and innovation program (Marie Skłodowska-Curie grant 101034413 to B.L.S.); the European Research Council (ERC) of the European Union (grant ActinID 101076260 to F.K.M.S.); the Swiss National Science Foundation (starting grant TMSGI3_226208 to G.L.W.); and the Jean-Jacques et Letitia Lopez-Loreta Foundation (G.L.W.)." article_number: eaea6343 article_processing_charge: No article_type: original author: - first_name: Benjamin L full_name: Springstein, Benjamin L id: b4eb62ef-ac72-11ed-9503-ed3b4d66c083 last_name: Springstein orcid: 0000-0002-3461-5391 - first_name: Manjunath full_name: Javoor, Manjunath id: 305ab18b-dc7d-11ea-9b2f-b58195228ea2 last_name: Javoor orcid: 0000-0003-2311-2112 - first_name: Daniela full_name: Megrian, Daniela last_name: Megrian - first_name: Roman full_name: Hajdu, Roman id: ffab949d-133f-11ed-8f02-94de21ace503 last_name: Hajdu - first_name: Dustin M. full_name: Hanke, Dustin M. last_name: Hanke - first_name: Bettina full_name: Zens, Bettina id: 45FD126C-F248-11E8-B48F-1D18A9856A87 last_name: Zens orcid: 0000-0002-9561-1239 - first_name: Gregor L. full_name: Weiss, Gregor L. last_name: Weiss - first_name: Florian Km full_name: Schur, Florian Km id: 48AD8942-F248-11E8-B48F-1D18A9856A87 last_name: Schur orcid: 0000-0003-4790-8078 - first_name: Martin full_name: Loose, Martin id: 462D4284-F248-11E8-B48F-1D18A9856A87 last_name: Loose orcid: 0000-0001-7309-9724 citation: ama: Springstein BL, Javoor M, Megrian D, et al. Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. Science. 2026;392(6795). doi:10.1126/science.aea6343 apa: Springstein, B. L., Javoor, M., Megrian, D., Hajdu, R., Hanke, D. M., Zens, B., … Loose, M. (2026). Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. Science. AAAS. https://doi.org/10.1126/science.aea6343 chicago: Springstein, Benjamin L, Manjunath Javoor, Daniela Megrian, Roman Hajdu, Dustin M. Hanke, Bettina Zens, Gregor L. Weiss, Florian KM Schur, and Martin Loose. “Repurposing of a DNA Segregation Machinery into a Cytoskeletal System Controlling Cell Shape.” Science. AAAS, 2026. https://doi.org/10.1126/science.aea6343. ieee: B. L. Springstein et al., “Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape,” Science, vol. 392, no. 6795. AAAS, 2026. ista: Springstein BL, Javoor M, Megrian D, Hajdu R, Hanke DM, Zens B, Weiss GL, Schur FK, Loose M. 2026. Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. Science. 392(6795), eaea6343. mla: Springstein, Benjamin L., et al. “Repurposing of a DNA Segregation Machinery into a Cytoskeletal System Controlling Cell Shape.” Science, vol. 392, no. 6795, eaea6343, AAAS, 2026, doi:10.1126/science.aea6343. short: B.L. Springstein, M. Javoor, D. Megrian, R. Hajdu, D.M. Hanke, B. Zens, G.L. Weiss, F.K. Schur, M. Loose, Science 392 (2026). corr_author: '1' date_created: 2026-04-26T22:01:46Z date_published: 2026-04-16T00:00:00Z date_updated: 2026-04-28T13:29:05Z day: '16' department: - _id: MaLo - _id: FlSc - _id: GradSch - _id: EM-Fac doi: 10.1126/science.aea6343 ec_funded: 1 external_id: pmid: - '41990175' intvolume: ' 392' issue: '6795' language: - iso: eng month: '04' oa_version: None pmid: 1 project: - _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c call_identifier: H2020 grant_number: '101034413' name: 'IST-BRIDGE: International postdoctoral program' - _id: bd980d18-d553-11ed-ba76-ceaa645c97eb grant_number: '101076260' name: A molecular atlas of Actin filament IDentities in the cell motility machinery publication: Science publication_identifier: eissn: - 1095-9203 issn: - 0036-8075 publication_status: published publisher: AAAS quality_controlled: '1' scopus_import: '1' status: public title: Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 392 year: '2026' ... --- OA_place: repository OA_type: green _id: '21763' abstract: - lang: eng text: Reactive oxygen species (ROS) have been implicated in multiple signaling processes in plants, but the underlying mechanisms and roles remain enigmatic. In this study, we developed a method of live imaging of apoplastic ROS at the root surface. Distinct signals, including auxin, extracellular adenosine triphosphate, and rapid alkalinization factor 1 peptide, induce cytosolic calcium transients and apoplastic ROS bursts. Genetic and optogenetic manipulations of Arabidopsis identified calcium transients as necessary and sufficient for ROS bursts through activation of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidases RBOHC and RBOHF. Apoplastic ROS bursts are not required, but they do limit gravity-induced root bending. Root bending is sensed by the stretch-activated calcium channel MCA1, leading to NADPH oxidase activation. The resulting ROS production stiffens cell walls to facilitate soil penetration. Apoplastic ROS thus provides a means to balance tissue flexibility and stiffness to navigate soil. acknowledged_ssus: - _id: LifeSc - _id: Bio acknowledgement: "We gratefully acknowledge the Lab Support Facility (LSF) and the Imaging and Optics Facility (IOF) (both of ISTA) and the Hounsfield CT Facility (University of Nottingham) for support with imaging and the Growth Facility (IPMB) for plant cultivation. We thank M. Fendrych and his team for help with the microfluidics upgrades and J. Atkinson at the University of Nottingham MakerSpace for 3D printing of Arabidopsis mini-soil columns.\r\nThis project received funding from the European Research Council (ERC; 101142681 CYNIPS) and the Austrian Science Fund (FWF; P 37051-B). I.K. was cofunded by the European Union, Horizon Europe, project MOLIPEC, ID 101087030 and CSF project 25-16449S. L.V. and B.K.P. acknowledge funding from UK Research and Innovation (UKRI) Frontiers Research (EP/Y036697/1). M.J.B. acknowledges funding from ERC SYNERGY (grant 101118769 HYDROSENSING). The study was partially supported by the Université Paris Cité, Idex ANR-18-IDEX-0001, funded by the French Government through its “Investments for the Future” program and also by the projects “Mecha-Nuc” ANR-20-CE13-0025-03 and “scEm-bryoMech” ANR-21-CE13-0046. P.D. acknowledges support by Human Frontier Science Program Organization grant 2022-RG107. P.V. acknowledges support provided by “Programme blanc” of the Graduate School BIOSPHERA, Université Paris-Saclay. Phytohormonal analysis was performed using the service laboratory funded by Toward Next GENeration Crops, reg. no. CZ.02.01.01/00/22_008/0004581 of the European Regional Development Fund (ERDF) program Johannes Amos Comenius. This research was funded in whole or in part by the Austrian Science Fund (P 37051-B) and UK Research and Innovation (EP/Y036697/1), cOAlition S organizations, and by the European Research Council (101142681 CYNIPS, 101118769 HYDROSENSING); as required, the author will make the Author Accepted Manuscript (AAM) version available under a CC BY public copyright license." article_processing_charge: No article_type: original author: - first_name: Ivan full_name: Kulich, Ivan id: 57a1567c-8314-11eb-9063-c9ddc3451a54 last_name: Kulich - first_name: Dmitrii full_name: Vladimirtsev, Dmitrii id: 60466724-5355-11ee-ae5a-fa55e8f99c3d last_name: Vladimirtsev - first_name: Marek full_name: Randuch, Marek id: 6ac4636d-15b2-11ec-abd3-fb8df79972ae last_name: Randuch - first_name: Shiqiang full_name: Gao, Shiqiang last_name: Gao - first_name: Matteo full_name: Citterico, Matteo last_name: Citterico - first_name: Kai R. full_name: Konrad, Kai R. last_name: Konrad - first_name: Georg full_name: Nagel, Georg last_name: Nagel - first_name: Michael full_name: Wrzaczek, Michael last_name: Wrzaczek - first_name: Léa full_name: Cascaro, Léa last_name: Cascaro - first_name: Pauline full_name: Vinet, Pauline last_name: Vinet - first_name: Pauline full_name: Durand, Pauline last_name: Durand - first_name: Atef full_name: Asnacios, Atef last_name: Asnacios - first_name: Lokesh full_name: Verma, Lokesh last_name: Verma - first_name: Malcolm J. full_name: Bennett, Malcolm J. last_name: Bennett - first_name: Bipin K. full_name: Pandey, Bipin K. last_name: Pandey - first_name: Jiří full_name: Friml, Jiří id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 citation: ama: Kulich I, Vladimirtsev D, Randuch M, et al. Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation. Science. 2026;392(6795):296-300. doi:10.1126/science.adu8197 apa: Kulich, I., Vladimirtsev, D., Randuch, M., Gao, S., Citterico, M., Konrad, K. R., … Friml, J. (2026). Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation. Science. AAAS. https://doi.org/10.1126/science.adu8197 chicago: Kulich, Ivan, Dmitrii Vladimirtsev, Marek Randuch, Shiqiang Gao, Matteo Citterico, Kai R. Konrad, Georg Nagel, et al. “Calcium-Triggered Apoplastic ROS Bursts Balance Gravity and Mechanical Signals for Soil Navigation.” Science. AAAS, 2026. https://doi.org/10.1126/science.adu8197. ieee: I. Kulich et al., “Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation,” Science, vol. 392, no. 6795. AAAS, pp. 296–300, 2026. ista: Kulich I, Vladimirtsev D, Randuch M, Gao S, Citterico M, Konrad KR, Nagel G, Wrzaczek M, Cascaro L, Vinet P, Durand P, Asnacios A, Verma L, Bennett MJ, Pandey BK, Friml J. 2026. Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation. Science. 392(6795), 296–300. mla: Kulich, Ivan, et al. “Calcium-Triggered Apoplastic ROS Bursts Balance Gravity and Mechanical Signals for Soil Navigation.” Science, vol. 392, no. 6795, AAAS, 2026, pp. 296–300, doi:10.1126/science.adu8197. short: I. Kulich, D. Vladimirtsev, M. Randuch, S. Gao, M. Citterico, K.R. Konrad, G. Nagel, M. Wrzaczek, L. Cascaro, P. Vinet, P. Durand, A. Asnacios, L. Verma, M.J. Bennett, B.K. Pandey, J. Friml, Science 392 (2026) 296–300. corr_author: '1' date_created: 2026-04-26T22:01:47Z date_published: 2026-04-16T00:00:00Z date_updated: 2026-05-07T06:20:07Z day: '16' ddc: - '580' department: - _id: JiFr - _id: GradSch doi: 10.1126/science.adu8197 external_id: pmid: - '41990180' file: - access_level: open_access checksum: eb5b29247832ecdc53c8146da0509bbe content_type: application/pdf creator: dernst date_created: 2026-05-07T05:54:43Z date_updated: 2026-05-07T05:54:43Z file_id: '21832' file_name: 2026_Science_Kulich_accepted.pdf file_size: 6150733 relation: main_file success: 1 file_date_updated: 2026-05-07T05:54:43Z has_accepted_license: '1' intvolume: ' 392' issue: '6795' language: - iso: eng month: '04' oa: 1 oa_version: Accepted Version page: 296-300 pmid: 1 project: - _id: 8f347782-16d5-11f0-9cad-8c19706ee739 grant_number: '101142681' name: Cyclic nucleotides as second messengers in plants - _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6 grant_number: P37051 name: Guanylate cyclase activity of TIR1/AFBs auxin receptors publication: Science publication_identifier: eissn: - 1095-9203 issn: - 0036-8075 publication_status: published publisher: AAAS quality_controlled: '1' scopus_import: '1' status: public title: Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 392 year: '2026' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '21764' abstract: - lang: eng text: "Colloidal fluids can exhibit complex phase behavior and determining phase diagrams via experiments or computer simulations can be laborious. We demonstrate that the dispersion relation ω(k), obtained from dynamical density functional theory for the uniform density system, is a highly versatile tool for predicting where in the phase diagram complex crystals form. The sign of ω(k) determines whether density modes with wave number k grow or decay over time. We demonstrate the predictive power by investigating the complex phase behavior of particles interacting via core-shoulder pair potentials. With complementary Monte Carlo simulations, we show that regions of the phase diagram where ωðkÞ has one or several unstable (growing) wave numbers are also where crystalline phases occur. Going further, by tuning these\r\nunstable wave numbers via the interaction-potential and state-point parameters, we design systems with quasicrystals in the phase diagram. We identify a system with a certain shoulder range exhibiting at least ten different phases. Our general approach accelerates considerably the mapping of complex phase diagrams, crucial for the design of new materials." acknowledgement: "The authors thank Ms. Katrin Muck for her guidance related to the use of HPC. The MC\r\ncomputer simulation results presented here were enabled via a generous share of CPU time, offered by the Vienna Scientific Cluster (VSC) under Project No. 71263. A. J. A. gratefully acknowledges support from the EPSRC under Grant No. EP/P015689/1. This research was funded in part by the Austrian Science Fund (FWF) [Grant DOI: 10.55776/PIN8759524], gratefully acknowledged by G. K ." article_number: '148203' article_processing_charge: Yes (in subscription journal) article_type: original arxiv: 1 author: - first_name: Michael full_name: Wassermair, Michael id: 23d132c4-4e98-11ef-b275-9e8d4cd8c917 last_name: Wassermair orcid: 0009-0003-6339-4051 - first_name: Gerhard full_name: Kahl, Gerhard last_name: Kahl - first_name: Roland full_name: Roth, Roland last_name: Roth - first_name: Andrew J. full_name: Archer, Andrew J. last_name: Archer citation: ama: Wassermair M, Kahl G, Roth R, Archer AJ. Navigating complex phase diagrams in soft matter systems. Physical Review Letters. 2026;136(14). doi:10.1103/nbvt-fgjy apa: Wassermair, M., Kahl, G., Roth, R., & Archer, A. J. (2026). Navigating complex phase diagrams in soft matter systems. Physical Review Letters. American Physical Society. https://doi.org/10.1103/nbvt-fgjy chicago: Wassermair, Michael, Gerhard Kahl, Roland Roth, and Andrew J. Archer. “Navigating Complex Phase Diagrams in Soft Matter Systems.” Physical Review Letters. American Physical Society, 2026. https://doi.org/10.1103/nbvt-fgjy. ieee: M. Wassermair, G. Kahl, R. Roth, and A. J. Archer, “Navigating complex phase diagrams in soft matter systems,” Physical Review Letters, vol. 136, no. 14. American Physical Society, 2026. ista: Wassermair M, Kahl G, Roth R, Archer AJ. 2026. Navigating complex phase diagrams in soft matter systems. Physical Review Letters. 136(14), 148203. mla: Wassermair, Michael, et al. “Navigating Complex Phase Diagrams in Soft Matter Systems.” Physical Review Letters, vol. 136, no. 14, 148203, American Physical Society, 2026, doi:10.1103/nbvt-fgjy. short: M. Wassermair, G. Kahl, R. Roth, A.J. Archer, Physical Review Letters 136 (2026). date_created: 2026-04-26T22:01:47Z date_published: 2026-04-10T00:00:00Z date_updated: 2026-04-28T07:03:48Z day: '10' ddc: - '530' department: - _id: AnSa - _id: GradSch doi: 10.1103/nbvt-fgjy external_id: arxiv: - '2603.18918' file: - access_level: open_access checksum: 8ffb139122a185fcddbe6a9c901a287c content_type: application/pdf creator: dernst date_created: 2026-04-28T06:58:40Z date_updated: 2026-04-28T06:58:40Z file_id: '21769' file_name: 2026_PhysicalReviewLetters_Wassermair.pdf file_size: 4336488 relation: main_file success: 1 file_date_updated: 2026-04-28T06:58:40Z has_accepted_license: '1' intvolume: ' 136' issue: '14' language: - iso: eng month: '04' oa: 1 oa_version: Published Version publication: Physical Review Letters publication_identifier: eissn: - 1079-7114 issn: - 0031-9007 publication_status: published publisher: American Physical Society quality_controlled: '1' scopus_import: '1' status: public title: Navigating complex phase diagrams in soft matter systems tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 136 year: '2026' ... --- OA_type: closed access _id: '21765' abstract: - lang: eng text: "Dielectric particles of the same material exchange electrical charge during collisions or sliding contacts, yet the underlying charge-exchange mechanism is still not understood. The fact that particles can become highly charged as a result of this effect has significant consequences for many settings, both in nature and industry, such as thunderstorms, volcanic eruptions, particle aggregation during meteorite and planet formation, and the clogging of industrial granular systems. Toward understanding these systems, great efforts have been made to develop precise in situ measurements for particle charge, e.g., to determine ensemble charge distributions or measure exchange during individual contacts. Here, we present experimental results concerning the particle size scaling of the stationary-state charge distributions of oxide particles in the sub-millimeter range. We measure the charge distributions for large ensembles of monodisperse ZrO2:SiO2 composite spheres, ranging from 172 to 545µ⁢m in diameter. These distributions are non-Gaussian and collapse to a single master curve when plotted as functions of the surface charge density Σ=\U0001D45E/4⁢\U0001D70B⁢\U0001D4452. X-ray fluorescence and atomic force microscopy measurements show that the differences in the measured charge distributions are not due to variations in chemical composition or surface roughness, but rather to size alone. Our findings provide constraints on microscopic models for charge exchange, namely that they should lead to steady-state distributions that are non-Gaussian and scale in a specific way with particle size." acknowledgement: This research was supported by ANID Grants QUIMAL No. 160001, FONDECYT No. 1221597, and FONDEQUIP No. EQM190177. The authors thank Rodrigo Espinoza for the EDS-SEM measurements and Domingo Jullian for fruitful discussions. We also acknowledge the technical assistance of Ricardo Silva and Andrés Espinosa at DFI, FCFM, Universidad de Chile. article_number: '045604' article_processing_charge: No article_type: original author: - first_name: Macarena full_name: Lara, Macarena last_name: Lara - first_name: Marcos full_name: Flores, Marcos last_name: Flores - first_name: Gustavo full_name: Castillo, Gustavo last_name: Castillo - first_name: Santiago full_name: Tassara, Santiago last_name: Tassara - first_name: Scott R full_name: Waitukaitis, Scott R id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87 last_name: Waitukaitis orcid: 0000-0002-2299-3176 - first_name: Nicolás full_name: Mujica, Nicolás last_name: Mujica citation: ama: Lara M, Flores M, Castillo G, Tassara S, Waitukaitis SR, Mujica N. Particle size scaling of non-Gaussian granular charge distributions. Physical Review Materials. 2026;10(4). doi:10.1103/qw6t-xqdw apa: Lara, M., Flores, M., Castillo, G., Tassara, S., Waitukaitis, S. R., & Mujica, N. (2026). Particle size scaling of non-Gaussian granular charge distributions. Physical Review Materials. American Physical Society. https://doi.org/10.1103/qw6t-xqdw chicago: Lara, Macarena, Marcos Flores, Gustavo Castillo, Santiago Tassara, Scott R Waitukaitis, and Nicolás Mujica. “Particle Size Scaling of Non-Gaussian Granular Charge Distributions.” Physical Review Materials. American Physical Society, 2026. https://doi.org/10.1103/qw6t-xqdw. ieee: M. Lara, M. Flores, G. Castillo, S. Tassara, S. R. Waitukaitis, and N. Mujica, “Particle size scaling of non-Gaussian granular charge distributions,” Physical Review Materials, vol. 10, no. 4. American Physical Society, 2026. ista: Lara M, Flores M, Castillo G, Tassara S, Waitukaitis SR, Mujica N. 2026. Particle size scaling of non-Gaussian granular charge distributions. Physical Review Materials. 10(4), 045604. mla: Lara, Macarena, et al. “Particle Size Scaling of Non-Gaussian Granular Charge Distributions.” Physical Review Materials, vol. 10, no. 4, 045604, American Physical Society, 2026, doi:10.1103/qw6t-xqdw. short: M. Lara, M. Flores, G. Castillo, S. Tassara, S.R. Waitukaitis, N. Mujica, Physical Review Materials 10 (2026). date_created: 2026-04-26T22:01:47Z date_published: 2026-04-01T00:00:00Z date_updated: 2026-04-28T07:13:56Z day: '01' department: - _id: ScWa doi: 10.1103/qw6t-xqdw intvolume: ' 10' issue: '4' language: - iso: eng month: '04' oa_version: None publication: Physical Review Materials publication_identifier: eissn: - 2475-9953 publication_status: published publisher: American Physical Society quality_controlled: '1' scopus_import: '1' status: public title: Particle size scaling of non-Gaussian granular charge distributions type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 10 year: '2026' ... --- OA_place: publisher OA_type: hybrid _id: '21766' abstract: - lang: eng text: We provide a new characterisation of the decades old open problem of extending bilipschitz mappings given on a Euclidean separated net. In particular, this allows for the complete positive solution of the open problem in dimension two. Along the way, we develop a set of tools for bilipschitz extensions of mappings between subsets of Euclidean spaces. acknowledgement: "The present work developed from a research visit of M.D. to V.K. at IST Austria, funded by\r\na London Mathematical Society Research in Pairs grant. This work was done while V.K. was fully funded by the Austria Science Fund (FWF) [M 3100-N]." article_processing_charge: Yes (in subscription journal) article_type: original arxiv: 1 author: - first_name: Michael full_name: Dymond, Michael last_name: Dymond - first_name: Vojtech full_name: Kaluza, Vojtech id: 21AE5134-9EAC-11EA-BEA2-D7BD3DDC885E last_name: Kaluza orcid: 0000-0002-2512-8698 citation: ama: Dymond M, Kaluza V. Extending bilipschitz mappings between separated nets. Annales Fennici Mathematici. 2026;51(1):237-260. doi:10.54330/afm.181562 apa: Dymond, M., & Kaluza, V. (2026). Extending bilipschitz mappings between separated nets. Annales Fennici Mathematici. Finnish Mathematical Society. https://doi.org/10.54330/afm.181562 chicago: Dymond, Michael, and Vojtech Kaluza. “Extending Bilipschitz Mappings between Separated Nets.” Annales Fennici Mathematici. Finnish Mathematical Society, 2026. https://doi.org/10.54330/afm.181562. ieee: M. Dymond and V. Kaluza, “Extending bilipschitz mappings between separated nets,” Annales Fennici Mathematici, vol. 51, no. 1. Finnish Mathematical Society, pp. 237–260, 2026. ista: Dymond M, Kaluza V. 2026. Extending bilipschitz mappings between separated nets. Annales Fennici Mathematici. 51(1), 237–260. mla: Dymond, Michael, and Vojtech Kaluza. “Extending Bilipschitz Mappings between Separated Nets.” Annales Fennici Mathematici, vol. 51, no. 1, Finnish Mathematical Society, 2026, pp. 237–60, doi:10.54330/afm.181562. short: M. Dymond, V. Kaluza, Annales Fennici Mathematici 51 (2026) 237–260. corr_author: '1' date_created: 2026-04-26T22:01:47Z date_published: 2026-04-17T00:00:00Z date_updated: 2026-04-28T12:06:00Z day: '17' ddc: - '510' department: - _id: UlWa doi: 10.54330/afm.181562 external_id: arxiv: - '2507.22007' file: - access_level: open_access checksum: 442023926a3803d5d6ca8db8dbc4af1c content_type: application/pdf creator: dernst date_created: 2026-04-28T12:03:13Z date_updated: 2026-04-28T12:03:13Z file_id: '21772' file_name: 2026_AnnalesFenniciMath_Dymond.pdf file_size: 342082 relation: main_file success: 1 file_date_updated: 2026-04-28T12:03:13Z has_accepted_license: '1' intvolume: ' 51' issue: '1' keyword: - Lipschitz - bilipschitz - extension - separated net. language: - iso: eng month: '04' oa: 1 oa_version: Published Version page: 237-260 project: - _id: fc35eaa2-9c52-11eb-aca3-88501ab155e9 grant_number: M03100 name: Spectra and topology of graphs and of simplicial complexes publication: Annales Fennici Mathematici publication_identifier: eissn: - 2737-114X issn: - 2737-0690 publication_status: published publisher: Finnish Mathematical Society quality_controlled: '1' scopus_import: '1' status: public title: Extending bilipschitz mappings between separated nets tmp: image: /images/cc_by_nc.png legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) short: CC BY-NC (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 51 year: '2026' ... --- OA_place: publisher OA_type: hybrid _id: '21767' abstract: - lang: eng text: 'The involvement of non-scientific staff in discussions about animal welfare and scientific quality is essential for biomedical research progress. In this study, we developed a survey to collect the self-perception of animal care staff (ACS) and laboratory technicians about their involvement in scientific planning and conduct. Participants were contacted to complete an anonymous online questionnaire. We obtained 850 responses, mainly from Europe: 564 from ACS and 286 from laboratory technicians. Job satisfaction was assessed as positive by ACS and laboratory technicians despite the low frequency of culture of care activities and mental health meetings. Both groups expressed their desire to be trained in research planning and conduct; however, regular training was not reported. In addition, the inability to act on animal welfare concerns owing to experimental reasons was reported by both groups. Over half of the participants felt valued and appreciated by the lead scientists or animal facility manager; however, it is not clear how they are acknowledged, as their names on the authors list or in the manuscript acknowledgments are barely included. Our results indicated that involvement of ACS and laboratory technicians in planning and conducting studies would improve their understanding of how experiments are done, and therefore communication processes, work satisfaction, animal welfare, and scientific quality. Finally, we provided recommendations to improve the engagement of ACS and laboratory technicians in discussions about animal research planning and conduct.' - lang: fre text: 'La participation de personnel non-scientifique aux discussions sur le bien-être animal et la qualité scientifique est essentielle aux progrès la recherche biomédicale. Dans cette étude, nous avons développé une enquête pour recueillir l''auto-perception du personnel chargé des soins prodigués aux animaux (PCSA) et des techniciens de laboratoire (TL) sur leur implication dans la planification et la conduite scientifiques. Les participants ont été contactés pour remplir un questionnaire anonyme en ligne. Nous avons obtenu 850 réponses, principalement en Europe : 564 provenant de PCSA et 286 de TL. La satisfaction au travail a été évaluée comme positive par le PCSA et les TL malgré la faible fréquence d’activités sur la culture des soins et de réunions concernant la santé mentale. Bien que les deux groupes aient exprimé leur désir d''être formés à la planification et à la conduite de la recherche, aucune formation réelle régulière n''a été signalée. De plus, l''incapacité d''agir sur les préoccupations relatives au bien-être animal pour des raisons expérimentales a été signalée par les deux groupes. Plus de la moitié des participants se sont sentis valorisés et appréciés par les scientifiques principaux ou le gestionnaire de l’installation animale mais on ne sait pas clairement comment ils sont reconnus, car leurs noms sur la liste des auteurs ou dans les remerciements sont à peine inclus dans la documentation. Nos résultats ont indiqué que la participation du PCSA et des TL à la planification et à la conduite des études améliorerait leur compréhension de la façon dont les expériences sont effectuées et, par conséquent, les processus de communication, leur satisfaction au travail ainsi que le bien-être animal et la qualité scientifique. Enfin, nous avons formulé des recommandations pour améliorer la participation du PCSA et des TL aux discussions sur la planification et la conduite de la recherche animale.' - lang: ger text: 'Die Einbeziehung von nichtwissenschaftlichem Personal in Diskussionen über Tierschutz und wissenschaftliche Qualität ist für Fortschritte in biomedizinischer Forschung von entscheidender Bedeutung. In dieser Studie haben wir eine Umfrage entwickelt, um die Selbsteinschätzung von Tierpflegern (ACS) und Labortechnikern (LT) hinsichtlich ihrer Beteiligung an der wissenschaftlichen Planung und Durchführung zu erfassen. Die Teilnehmer wurden gebeten, einen anonymen Online-Fragebogen auszufüllen. Wir erhielten 850 Rückmeldungen, hauptsächlich aus Europa: 564 von ACS und 286 von LT. Die Arbeitszufriedenheit wurde von ACS und LT trotz der geringen Häufigkeit von Pflegeaktivitäten und Treffen zum Thema psychische Gesundheit als positiv bewertet. Beide Gruppen äußerten den Wunsch, in der Forschungsplanung und -durchführung geschult zu werden, doch regelmäßig stattfindende Schulungen wurden nicht berichtet. Außerdem wurde von beiden Gruppen vermeldet, dass sie aus versuchstechnischen Gründen nicht in der Lage waren, auf Tierschutzbedenken zu reagieren. Über die Hälfte der Teilnehmer fühlte sich von den leitenden Wissenschaftlern oder dem Leiter der Tierhaltungseinrichtung geschätzt und anerkannt; es ist jedoch unklar, inwiefern sie wirklich gewürdigt werden, da ihre Namen kaum in der Autorenliste oder in den Danksagungen des Manuskripts aufgeführt sind. Unsere Ergebnisse deuteten darauf hin, dass die Einbeziehung von ACS und LT in die Planung und Durchführung von Studien ihr Verständnis für die Durchführung von Experimenten verbessern würde – und damit auch Kommunikationsprozesse, Arbeitszufriedenheit, Tierwohl und wissenschaftliche Qualität. Abschließend gaben wir Empfehlungen zur Verbesserung der Einbeziehung von ACS und LT in Diskussionen über die Planung und Durchführung von Tierversuchen.' - lang: spa text: 'La participación del personal no científico en los debates sobre el bienestar animal y la calidad científica es fundamental para el avance de la investigación biomédica. En este estudio, desarrollamos una encuesta para recoger la autopercepción del personal encargado del cuidado de los animales (ACS) y de los técnicos de laboratorio (LT) sobre su implicación en la planificación y la realización científicas. Se contactó con los participantes para que cumplimentaran un cuestionario anónimo en línea. Obtuvimos 850 respuestas, principalmente de Europa: 564 de ACS y 286 de LT. La satisfacción laboral fue evaluada como positiva por ACS y técnicos de laboratorio a pesar de la baja frecuencia de actividades de cultura del cuidado y reuniones sobre bienestar mental. Ambos grupos expresaron su deseo de recibir formación en planificación y realización de investigaciones, sin embargo, no se informó sobre una formación regular. Asimismo, ambos grupos señalaron la incapacidad de actuar ante las preocupaciones sobre el bienestar animal por motivos experimentales. Más de la mitad de los participantes se sintieron valorados y apreciados por los científicos principales o el responsable de las instalaciones de animales; sin embargo, no está claro cómo se les reconoce, ya que apenas se incluyen sus nombres en la lista de autores o en los agradecimientos del manuscrito. Nuestros resultados indicaron que la participación de los ACS y los LT en la planificación y realización de los estudios mejoraría su comprensión de cómo se hacen los experimentos y, por tanto, los procesos de comunicación, la satisfacción laboral, el bienestar animal y la calidad científica. Finalmente, proporcionamos recomendaciones para mejorar el compromiso de la AEC y la LT en los debates sobre la planificación y la realización de investigaciones con animales.' acknowledgement: "We deeply acknowledge all the animal care staff and laboratory technicians who participated in this study! We acknowledge Working Groups 1 and 4 from COST Action IMPROVE (“3Rs concepts to improve the quality of biomedical science”), CA21139, supported by COST (European Cooperation in Science and Technology) for their feedback and support. We also acknowledge Aoife Milford for her comments and contributions to the final draft of the manuscript.\r\nThis publication was based on work from the COST Action IMPROVE (“3Rs concepts to improve the quality of biomedical science”), CA21139, supported by COST (European Cooperation in Science and Technology)." article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Fernando full_name: Gonzalez-Uarquin, Fernando last_name: Gonzalez-Uarquin - first_name: Paulin full_name: Jirkof, Paulin last_name: Jirkof - first_name: Bettina full_name: Bert, Bettina last_name: Bert - first_name: Penny full_name: Hawkins, Penny last_name: Hawkins - first_name: Ljupco full_name: Angelovski, Ljupco last_name: Angelovski - first_name: Jan full_name: Baumgart, Jan last_name: Baumgart - first_name: Nadine full_name: Baumgart, Nadine last_name: Baumgart - first_name: Özge S. full_name: Cevik, Özge S. last_name: Cevik - first_name: Nuno H. full_name: Franco, Nuno H. last_name: Franco - first_name: Erdal full_name: Horata, Erdal last_name: Horata - first_name: Rohish full_name: Kaura, Rohish last_name: Kaura - first_name: Winfried full_name: Neuhaus, Winfried last_name: Neuhaus - first_name: Brigida full_name: Riso, Brigida last_name: Riso - first_name: Adrian J. full_name: Smith, Adrian J. last_name: Smith - first_name: Athanassia full_name: Sotiropoulos, Athanassia last_name: Sotiropoulos - first_name: Augusto full_name: Vitale, Augusto last_name: Vitale - first_name: Sophie full_name: Schober, Sophie id: 80b0a0ef-4b9f-11ec-b119-8d9d94c4a1d8 last_name: Schober citation: ama: 'Gonzalez-Uarquin F, Jirkof P, Bert B, et al. Building bridges: Involvement of animal care staff and laboratory technicians in experimental planning and conduct of animal studies for better job satisfaction and science. Laboratory Animals. 2026. doi:10.1177/00236772251400976' apa: 'Gonzalez-Uarquin, F., Jirkof, P., Bert, B., Hawkins, P., Angelovski, L., Baumgart, J., … Schober, S. (2026). Building bridges: Involvement of animal care staff and laboratory technicians in experimental planning and conduct of animal studies for better job satisfaction and science. Laboratory Animals. SAGE Publications. https://doi.org/10.1177/00236772251400976' chicago: 'Gonzalez-Uarquin, Fernando, Paulin Jirkof, Bettina Bert, Penny Hawkins, Ljupco Angelovski, Jan Baumgart, Nadine Baumgart, et al. “Building Bridges: Involvement of Animal Care Staff and Laboratory Technicians in Experimental Planning and Conduct of Animal Studies for Better Job Satisfaction and Science.” Laboratory Animals. SAGE Publications, 2026. https://doi.org/10.1177/00236772251400976.' ieee: 'F. Gonzalez-Uarquin et al., “Building bridges: Involvement of animal care staff and laboratory technicians in experimental planning and conduct of animal studies for better job satisfaction and science,” Laboratory Animals. SAGE Publications, 2026.' ista: 'Gonzalez-Uarquin F, Jirkof P, Bert B, Hawkins P, Angelovski L, Baumgart J, Baumgart N, Cevik ÖS, Franco NH, Horata E, Kaura R, Neuhaus W, Riso B, Smith AJ, Sotiropoulos A, Vitale A, Schober S. 2026. Building bridges: Involvement of animal care staff and laboratory technicians in experimental planning and conduct of animal studies for better job satisfaction and science. Laboratory Animals.' mla: 'Gonzalez-Uarquin, Fernando, et al. “Building Bridges: Involvement of Animal Care Staff and Laboratory Technicians in Experimental Planning and Conduct of Animal Studies for Better Job Satisfaction and Science.” Laboratory Animals, SAGE Publications, 2026, doi:10.1177/00236772251400976.' short: F. Gonzalez-Uarquin, P. Jirkof, B. Bert, P. Hawkins, L. Angelovski, J. Baumgart, N. Baumgart, Ö.S. Cevik, N.H. Franco, E. Horata, R. Kaura, W. Neuhaus, B. Riso, A.J. Smith, A. Sotiropoulos, A. Vitale, S. Schober, Laboratory Animals (2026). date_created: 2026-04-26T22:01:47Z date_published: 2026-04-14T00:00:00Z date_updated: 2026-06-18T08:33:36Z day: '14' ddc: - '570' department: - _id: PreCl doi: 10.1177/00236772251400976 language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1177/00236772251400976 month: '04' oa: 1 oa_version: Published Version publication: Laboratory Animals publication_identifier: eissn: - 1758-1117 issn: - 0023-6772 publication_status: epub_ahead publisher: SAGE Publications quality_controlled: '1' scopus_import: '1' status: public title: 'Building bridges: Involvement of animal care staff and laboratory technicians in experimental planning and conduct of animal studies for better job satisfaction and science' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2026' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '21776' abstract: - lang: eng text: Pyridyl motifs equipped with N-substituents can be powerful ligands for catalysis, yet their broader adoption is limited by the lack of a practical method to prepare these scaffolds. We report a modular, robust, and versatile Buchwald–Hartwig amination protocol that enables the rapid synthesis of bipyridine, phenanthroline, terpyridine, and pybox ligands bearing dialkylamine, diarylamine, and heteroaromatic N-substituents. These conditions streamline ligand library synthesis and will facilitate systematic studies in catalysis and related applications. acknowledged_ssus: - _id: LifeSc - _id: MassSpec - _id: NMR - _id: M-Shop acknowledgement: We gratefully acknowledge ISTA for generous financial support. B.P. acknowledges the Austrian Science Fund (PAT 1250924) and the ACS GCI Pharmaceutical Roundtable for funding; T.P.Y acknowledges the NSF(CHE-2349003) for financial support. This research was supported by the Scientific Service Units (SSU) of ISTA through resources provided by the Lab Support Facility, Mass Spec Facility, NMR facility, and the Miba Machine Shop. We specifically thank Aikaterina Paraskevopoulou for HRMS measurements and Jan Pecak for support with ICP-OES experi-ments. NMR facilities at UW−Madison were supported by the NSF(CHE-1048642) and a generous gift from Paul J. and Margaret M. Bender. Open Access funding provided by Institute of Science and Technology Austria/KEMÖ. This study was supported by Austrian Science Fund (PAT 1250924), ACSGCI Pharmaceutical Roundtable, and National Science Foundation(CHE-2349003) and (CHE-1048642). article_number: e70417 article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Adam full_name: Petrik, Adam id: e273d403-329f-11ee-a353-8c34c056f8ed last_name: Petrik - first_name: Aleksander full_name: Bena, Aleksander id: 4197c39e-e8ec-11ed-86cb-afed934cd664 last_name: Bena - first_name: Haralds full_name: Baunis, Haralds id: 2eea55ec-e8ec-11ed-86cb-d9c76787acfe last_name: Baunis - first_name: Riley M. full_name: Kelch, Riley M. last_name: Kelch - first_name: Tehshik P. full_name: Yoon, Tehshik P. last_name: Yoon - first_name: Bartholomäus full_name: Pieber, Bartholomäus id: 93e5e5b2-0da6-11ed-8a41-af589a024726 last_name: Pieber orcid: 0000-0001-8689-388X citation: ama: Petrik A, Bena A, Baunis H, Kelch RM, Yoon TP, Pieber B. Facile access to N-substituted pyridyl ligands. Advanced Synthesis & Catalysis. 2026;368(9). doi:10.1002/adsc.70417 apa: Petrik, A., Bena, A., Baunis, H., Kelch, R. M., Yoon, T. P., & Pieber, B. (2026). Facile access to N-substituted pyridyl ligands. Advanced Synthesis & Catalysis. Wiley. https://doi.org/10.1002/adsc.70417 chicago: Petrik, Adam, Aleksander Bena, Haralds Baunis, Riley M. Kelch, Tehshik P. Yoon, and Bartholomäus Pieber. “Facile Access to N-Substituted Pyridyl Ligands.” Advanced Synthesis & Catalysis. Wiley, 2026. https://doi.org/10.1002/adsc.70417. ieee: A. Petrik, A. Bena, H. Baunis, R. M. Kelch, T. P. Yoon, and B. Pieber, “Facile access to N-substituted pyridyl ligands,” Advanced Synthesis & Catalysis, vol. 368, no. 9. Wiley, 2026. ista: Petrik A, Bena A, Baunis H, Kelch RM, Yoon TP, Pieber B. 2026. Facile access to N-substituted pyridyl ligands. Advanced Synthesis & Catalysis. 368(9), e70417. mla: Petrik, Adam, et al. “Facile Access to N-Substituted Pyridyl Ligands.” Advanced Synthesis & Catalysis, vol. 368, no. 9, e70417, Wiley, 2026, doi:10.1002/adsc.70417. short: A. Petrik, A. Bena, H. Baunis, R.M. Kelch, T.P. Yoon, B. Pieber, Advanced Synthesis & Catalysis 368 (2026). corr_author: '1' date_created: 2026-05-03T22:01:36Z date_published: 2026-05-05T00:00:00Z date_updated: 2026-05-07T07:33:33Z day: '05' ddc: - '540' department: - _id: BaPi - _id: GradSch doi: 10.1002/adsc.70417 file: - access_level: open_access checksum: afe9752977898642c903abdc70b4a283 content_type: application/pdf creator: dernst date_created: 2026-05-07T07:29:24Z date_updated: 2026-05-07T07:29:24Z file_id: '21833' file_name: 2026_AdvSynthCatal_Petrik.pdf file_size: 437184 relation: main_file success: 1 file_date_updated: 2026-05-07T07:29:24Z has_accepted_license: '1' intvolume: ' 368' issue: '9' language: - iso: eng month: '05' oa: 1 oa_version: Published Version project: - _id: 8f1d607d-16d5-11f0-9cad-ab453295ba5e grant_number: PAT 1250924 name: Photoactive ligands for transformative nickel catalysis publication: Advanced Synthesis & Catalysis publication_identifier: eissn: - 1615-4169 issn: - 1615-4150 publication_status: published publisher: Wiley quality_controlled: '1' scopus_import: '1' status: public title: Facile access to N-substituted pyridyl ligands tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 368 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '21777' abstract: - lang: eng text: The advantageous characteristics attributed to the 19F nucleus have made it a popular target for nuclear magnetic resonance (NMR) once again in recent years. Aside from solution NMR, an increasing number of studies have been conducted applying solid-state magic-angle spinning (MAS) NMR to fluorine-labelled samples. Here, the high chemical shift anisotropy and strong dipolar couplings can be utilised to get structural insights into proteins and measure long distances. Despite increasing popularity and promising benefits, the sensitivity of biomolecular 19F MAS NMR often suffers from slow longitudinal T1 relaxation and therefore long recycle delays. In this work, we expand paramagnetic doping, an approach commonly used to reduce proton T1 relaxation times, to 19F-labelled biological samples. We study the effect of Gd(DTPA) and Gd(DTPA-BMA) on 19F T1 and T2, and 13C T1 and T2 relaxation in a [5-19F13C]-tryptophan-labelled protein via 19F-detected MAS NMR experiments. The observed paramagnetic relaxation enhancement substantially reduces measurement times of 19F MAS NMR experiments without compromising resolution. Additionally, we report the chemical shift assignments of all four fluorotryptophan signals in the 12×39 kDa-large protein TET2 using a mutagenesis approach. acknowledged_ssus: - _id: NMR - _id: LifeSc acknowledgement: We thank Ben P. Tatman for insightful discussions. This research was supported by the Scientific Service Units (SSUs) of ISTA through resources provided by the Nuclear Magnetic Resonance Facility and the Lab Support Facility. We thank Prof. Tobias Madl (Medical University Graz) for a sample of Omniscan. Lea M. Becker is the recipient of a DOC fellowship of the Austrian Academy of Sciences at the Institute of Science and Technology Austria (grant no. PR10660EAW01). article_processing_charge: Yes article_type: original author: - first_name: Lea Marie full_name: Becker, Lea Marie id: 36336939-eb97-11eb-a6c2-c83f1214ca79 last_name: Becker orcid: 0000-0002-6401-5151 - first_name: Giorgia full_name: Toscano, Giorgia id: 334a5e40-8747-11f0-b671-ba1f5154b4b4 last_name: Toscano - first_name: Anna full_name: Kapitonova, Anna id: 9fb2a840-89e1-11ee-a8b7-cc5c7ba62471 last_name: Kapitonova - first_name: Rajkumar full_name: Singh, Rajkumar id: a3089acd-6806-11ee-bacc-f0c7d500ad20 last_name: Singh - first_name: Undina full_name: Guillerm, Undina id: bb74f472-ae54-11eb-9835-bc9c22fb1183 last_name: Guillerm - first_name: Roman J. full_name: Lichtenecker, Roman J. last_name: Lichtenecker - first_name: Paul full_name: Schanda, Paul id: 7B541462-FAF6-11E9-A490-E8DFE5697425 last_name: Schanda orcid: 0000-0002-9350-7606 citation: ama: Becker LM, Toscano G, Kapitonova A, et al. Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants. Magnetic Resonance. 2026;7(1):29-37. doi:10.5194/mr-7-29-2026 apa: Becker, L. M., Toscano, G., Kapitonova, A., Singh, R., Guillerm, U., Lichtenecker, R. J., & Schanda, P. (2026). Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants. Magnetic Resonance. Copernicus Publications. https://doi.org/10.5194/mr-7-29-2026 chicago: Becker, Lea Marie, Giorgia Toscano, Anna Kapitonova, Rajkumar Singh, Undina Guillerm, Roman J. Lichtenecker, and Paul Schanda. “Accelerated 19F Biomolecular Magic-Angle Spinning NMR with Paramagnetic Dopants.” Magnetic Resonance. Copernicus Publications, 2026. https://doi.org/10.5194/mr-7-29-2026. ieee: L. M. Becker et al., “Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants,” Magnetic Resonance, vol. 7, no. 1. Copernicus Publications, pp. 29–37, 2026. ista: Becker LM, Toscano G, Kapitonova A, Singh R, Guillerm U, Lichtenecker RJ, Schanda P. 2026. Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants. Magnetic Resonance. 7(1), 29–37. mla: Becker, Lea Marie, et al. “Accelerated 19F Biomolecular Magic-Angle Spinning NMR with Paramagnetic Dopants.” Magnetic Resonance, vol. 7, no. 1, Copernicus Publications, 2026, pp. 29–37, doi:10.5194/mr-7-29-2026. short: L.M. Becker, G. Toscano, A. Kapitonova, R. Singh, U. Guillerm, R.J. Lichtenecker, P. Schanda, Magnetic Resonance 7 (2026) 29–37. corr_author: '1' date_created: 2026-05-03T22:01:36Z date_published: 2026-04-16T00:00:00Z date_updated: 2026-05-07T06:49:59Z day: '16' ddc: - '540' department: - _id: PaSc - _id: GradSch doi: 10.5194/mr-7-29-2026 external_id: pmid: - '42057802' has_accepted_license: '1' intvolume: ' 7' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.5194/mr-7-29-2026 month: '04' oa: 1 oa_version: Published Version page: 29-37 pmid: 1 project: - _id: B67AFEDC-15C9-11EA-A837-991A96BB2854 name: IST Austria Open Access Fund - _id: 7be609c4-9f16-11ee-852c-85015ce2b9b0 grant_number: '26777' name: Exploring protein dynamics by solid-state MAS NMR through specific labeling approaches publication: Magnetic Resonance publication_identifier: eissn: - 2699-0016 publication_status: published publisher: Copernicus Publications quality_controlled: '1' scopus_import: '1' status: public title: Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 7 year: '2026' ... --- OA_place: publisher OA_type: hybrid _id: '21778' abstract: - lang: eng text: "We prove that every \U0001D43F-bilipschitz mapping ℤ 2 → ℝ2 canbe extended to a \U0001D436(\U0001D43F)-bilipschitz mapping ℝ2 → ℝ2,and we provide a polynomial upper bound for \U0001D436(\U0001D43F).Moreover, we extend the result to every separated netin ℝ2 instead of ℤ 2, with the upper bound gaininga polynomial dependence on the separation and netconstants associated to the given separated net. Thisanswers an Oberwolfach question of Navas from 2015and is also a positive solution of the two-dimensionalform of a decades old open (in all dimensions at leasttwo) problem due to Alestalo Trotsenko and Väisälä." acknowledgement: The authors wish to thank Professor Leonid Kovalev for a valuable observation on the first versionof this work, which led to improved estimates and cleaner proofs in Section 6. The present workdeveloped from a research visit of Michael Dymond to Vojtěch Kaluža at IST Austria, funded by aLondon Mathematical Society Research in Pairs grant. This work was done whilst Vojtěch Kalužawas fully funded by the Austria Science Fund (FWF) [M 3100-N]. article_number: e70540 article_processing_charge: Yes (in subscription journal) article_type: original arxiv: 1 author: - first_name: Michael full_name: Dymond, Michael last_name: Dymond - first_name: Vojtech full_name: Kaluza, Vojtech id: 21AE5134-9EAC-11EA-BEA2-D7BD3DDC885E last_name: Kaluza orcid: 0000-0002-2512-8698 citation: ama: Dymond M, Kaluza V. Planar bilipschitz extension from separated nets. Journal of the London Mathematical Society. 2026;113(4). doi:10.1112/jlms.70540 apa: Dymond, M., & Kaluza, V. (2026). Planar bilipschitz extension from separated nets. Journal of the London Mathematical Society. Wiley. https://doi.org/10.1112/jlms.70540 chicago: Dymond, Michael, and Vojtech Kaluza. “Planar Bilipschitz Extension from Separated Nets.” Journal of the London Mathematical Society. Wiley, 2026. https://doi.org/10.1112/jlms.70540. ieee: M. Dymond and V. Kaluza, “Planar bilipschitz extension from separated nets,” Journal of the London Mathematical Society, vol. 113, no. 4. Wiley, 2026. ista: Dymond M, Kaluza V. 2026. Planar bilipschitz extension from separated nets. Journal of the London Mathematical Society. 113(4), e70540. mla: Dymond, Michael, and Vojtech Kaluza. “Planar Bilipschitz Extension from Separated Nets.” Journal of the London Mathematical Society, vol. 113, no. 4, e70540, Wiley, 2026, doi:10.1112/jlms.70540. short: M. Dymond, V. Kaluza, Journal of the London Mathematical Society 113 (2026). date_created: 2026-05-03T22:01:37Z date_published: 2026-04-01T00:00:00Z date_updated: 2026-05-07T08:29:18Z day: '01' ddc: - '510' department: - _id: UlWa doi: 10.1112/jlms.70540 external_id: arxiv: - '2410.22294' file: - access_level: open_access checksum: 6dbfc7134f732d17c5c8467843a73e90 content_type: application/pdf creator: dernst date_created: 2026-05-07T08:27:43Z date_updated: 2026-05-07T08:27:43Z file_id: '21836' file_name: 2026_JourLondonMathSoc_Dymond.pdf file_size: 617569 relation: main_file success: 1 file_date_updated: 2026-05-07T08:27:43Z has_accepted_license: '1' intvolume: ' 113' issue: '4' language: - iso: eng month: '04' oa: 1 oa_version: Published Version project: - _id: fc35eaa2-9c52-11eb-aca3-88501ab155e9 grant_number: M03100 name: Spectra and topology of graphs and of simplicial complexes publication: Journal of the London Mathematical Society publication_identifier: eissn: - 1469-7750 issn: - 0024-6107 publication_status: published publisher: Wiley quality_controlled: '1' scopus_import: '1' status: public title: Planar bilipschitz extension from separated nets tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 113 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '21779' abstract: - lang: eng text: Acidomycin is an anti-mycobacterial antibiotic with a unique mode of action, targeting the biotin biosynthesis pathway. Despite being highly active against mycobacteria in vitro, its development as an anti-tubercular agent has been hindered due to suboptimal pharmacokinetics. Engineering of the acidomycin biosynthesis may yield new analogues with improved pharmacological properties. Here, we describe the identification of the acidomycin biosynthetic gene cluster (BGC) in a Streptomyces bacterium isolated from the rhizosphere of Edelweiss. Notably, the acidomycin BGC is located in proximity to the genes for the biosynthesis of stravidins, secondary metabolites targeting a different enzyme in the biotin biosynthesis pathway, and two genes for streptavidins, proteins that strongly bind and sequester biotin. The identity of the acidomycin BGC was confirmed via both gene knock-out and heterologous expression, which suggested that the fatty acid required for the formation of acidomycin's acyl chain is most likely scavenged from the biotin biosynthesis pathway. CRISPR/Cas9-assisted knock-out of the cytochrome P450-encoding gene in the acidomycin BGC resulted in a significant decrease in its yield but did not abrogate the biosynthesis completely. acknowledgement: This work was supported by the University of Vienna. The authors thank Anna Fabisikova from the Mass Spectrometry Centre and the team of the NMR Centre (both of the Faculty of Chemistry, University of Vienna and members of the Vienna Life Science Instruments) for assistance with data acquisition. Open Access funding provided by Universitat Wien. This work was supported by Universität Wien. article_number: e70357 article_processing_charge: Yes article_type: original author: - first_name: Anna full_name: Vignolle, Anna last_name: Vignolle - first_name: Martin full_name: Zehl, Martin id: 8e016d5b-5d77-11f0-86d2-96cdb3922a55 last_name: Zehl orcid: 0000-0001-9685-0373 - first_name: Jaime Felipe Guerrero full_name: Garzón, Jaime Felipe Guerrero last_name: Garzón - first_name: Olha full_name: Schneider, Olha last_name: Schneider - first_name: Johannes full_name: Gafriller, Johannes last_name: Gafriller - first_name: Ulrike full_name: Grienke, Ulrike last_name: Grienke - first_name: Rasmus H. full_name: Kirkegaard, Rasmus H. last_name: Kirkegaard - first_name: Sergey B. full_name: Zotchev, Sergey B. last_name: Zotchev citation: ama: Vignolle A, Zehl M, Garzón JFG, et al. Identification and characterisation of the gene cluster governing biosynthesis of the anti-mycobacterial antibiotic acidomycin. Microbial Biotechnology. 2026;19(4). doi:10.1111/1751-7915.70357 apa: Vignolle, A., Zehl, M., Garzón, J. F. G., Schneider, O., Gafriller, J., Grienke, U., … Zotchev, S. B. (2026). Identification and characterisation of the gene cluster governing biosynthesis of the anti-mycobacterial antibiotic acidomycin. Microbial Biotechnology. Wiley. https://doi.org/10.1111/1751-7915.70357 chicago: Vignolle, Anna, Martin Zehl, Jaime Felipe Guerrero Garzón, Olha Schneider, Johannes Gafriller, Ulrike Grienke, Rasmus H. Kirkegaard, and Sergey B. Zotchev. “Identification and Characterisation of the Gene Cluster Governing Biosynthesis of the Anti-Mycobacterial Antibiotic Acidomycin.” Microbial Biotechnology. Wiley, 2026. https://doi.org/10.1111/1751-7915.70357. ieee: A. Vignolle et al., “Identification and characterisation of the gene cluster governing biosynthesis of the anti-mycobacterial antibiotic acidomycin,” Microbial Biotechnology, vol. 19, no. 4. Wiley, 2026. ista: Vignolle A, Zehl M, Garzón JFG, Schneider O, Gafriller J, Grienke U, Kirkegaard RH, Zotchev SB. 2026. Identification and characterisation of the gene cluster governing biosynthesis of the anti-mycobacterial antibiotic acidomycin. Microbial Biotechnology. 19(4), e70357. mla: Vignolle, Anna, et al. “Identification and Characterisation of the Gene Cluster Governing Biosynthesis of the Anti-Mycobacterial Antibiotic Acidomycin.” Microbial Biotechnology, vol. 19, no. 4, e70357, Wiley, 2026, doi:10.1111/1751-7915.70357. short: A. Vignolle, M. Zehl, J.F.G. Garzón, O. Schneider, J. Gafriller, U. Grienke, R.H. Kirkegaard, S.B. Zotchev, Microbial Biotechnology 19 (2026). date_created: 2026-05-03T22:01:37Z date_published: 2026-04-01T00:00:00Z date_updated: 2026-05-07T08:22:41Z day: '01' ddc: - '570' department: - _id: MassSpec doi: 10.1111/1751-7915.70357 external_id: pmid: - '42036976' file: - access_level: open_access checksum: 8c8aa660cef5394167e06f187adbabf0 content_type: application/pdf creator: dernst date_created: 2026-05-07T08:21:06Z date_updated: 2026-05-07T08:21:06Z file_id: '21835' file_name: 2026_MicrobialBiotechnology_Vignolle.pdf file_size: 575492 relation: main_file success: 1 file_date_updated: 2026-05-07T08:21:06Z has_accepted_license: '1' intvolume: ' 19' issue: '4' language: - iso: eng month: '04' oa: 1 oa_version: Published Version pmid: 1 publication: Microbial Biotechnology publication_identifier: eissn: - 1751-7915 publication_status: published publisher: Wiley quality_controlled: '1' scopus_import: '1' status: public title: Identification and characterisation of the gene cluster governing biosynthesis of the anti-mycobacterial antibiotic acidomycin tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 19 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '21780' abstract: - lang: eng text: It is predicted that half or more of all cataclysmic variables (CVs) should have evolved past the period minimum and now exist as so-called period bouncers where a white dwarf should be accreting from a Roche lobe filling substellar companion. However, this prediction stands in stark contrast to observations, where only a few per cent of CVs are found in this evolutionary phase. A potential solution to this discrepancy is that a magnetic field emerges from within the white dwarf after the system has reached the period minimum. The transfer of angular momentum from the spin of the white dwarf into the orbit then pushes the two stars apart, detaching them for potentially billions of years. Here we present the discovery of ZTF J021804.16+071152.93, a detached 0.69 +- 0.01 M⁠, 19 MG magnetic white dwarf plus 37 +- 5MJup brown dwarf binary with an orbital period of 1.7 h. The kinematics of the system indicate that it is a high probability member of the Galactic thick disc. However, this strongly disagrees with the much younger age of the system obtained from the white dwarf parameters, implying that the system may have been accreting in the past. This system is therefore consistent with having detached as a result of the emergence of the magnetic field of the white dwarf when the system was still mass transferring, and may represent the ultimate fate for many (perhaps even most) CVs. acknowledgement: "The results presented in this paper are based on observations collected at the European Southern Observatory under programme IDs 113.D-0277 and 114.D-0066 and on observations made with the Gran Telescopio Canarias (programme ID GTC119-23B), installed in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias, on the island of La Palma.\r\n\r\nSGP acknowledges support by the Science and Technology Facilities Council (grant ST/B001174/1). ARM acknowledges support from MINECO under the PID2023-148661NB-I00 grant and by the AGAUR/Generalitat de Catalunya grant SGR-386/2021. RMO was funded by INTA through grant PRE-OBSERVATORIO and acknowledges support from project PID2023-146210NB-I00 funded by MICIU/AEI/10.13039/501100011033 and by ERDF/EU. MZ acknowledges support from FONDECYT (grants 1250525 and 1221059). VSD and HiPERCAM were funded by the Science and Technology Facilities Council (grant ST/Z000033/1). MRS thanks for support from FONDECYT (grant No. 1221059). This project received funding from the European Research Council under the European Union’s Horizon 2020 research and innovation programme (Grant agreement numbers 101002408-MOS100PC)." article_number: stag521 article_processing_charge: Yes article_type: original arxiv: 1 author: - first_name: S. G. full_name: Parsons, S. G. last_name: Parsons - first_name: A. J. full_name: Brown, A. J. last_name: Brown - first_name: S. L. full_name: Casewell, S. L. last_name: Casewell - first_name: S. P. full_name: Littlefair, S. P. last_name: Littlefair - first_name: Joannes C full_name: van Roestel, Joannes C id: 4d122fc8-6083-11f0-87a5-97d68b860333 last_name: van Roestel - first_name: A. full_name: Rebassa-Mansergas, A. last_name: Rebassa-Mansergas - first_name: R. full_name: Murillo-Ojeda, R. last_name: Murillo-Ojeda - first_name: M. full_name: Zorotovic, M. last_name: Zorotovic - first_name: M. R. full_name: Schreiber, M. R. last_name: Schreiber - first_name: S. full_name: Bagnulo, S. last_name: Bagnulo - first_name: M. A. full_name: Stroet, M. A. last_name: Stroet - first_name: N. full_name: Castro Segura, N. last_name: Castro Segura - first_name: V. S. full_name: Dhillon, V. S. last_name: Dhillon - first_name: M. J. full_name: Dyer, M. J. last_name: Dyer - first_name: J. A. full_name: Garbutt, J. A. last_name: Garbutt - first_name: M. J. full_name: Green, M. J. last_name: Green - first_name: D. full_name: Jarvis, D. last_name: Jarvis - first_name: M. R. full_name: Kennedy, M. R. last_name: Kennedy - first_name: P. full_name: Kerry, P. last_name: Kerry - first_name: J. full_name: Mccormac, J. last_name: Mccormac - first_name: J. full_name: Munday, J. last_name: Munday - first_name: I. full_name: Pelisoli, I. last_name: Pelisoli - first_name: E. full_name: Pike, E. last_name: Pike - first_name: D. I. full_name: Sahman, D. I. last_name: Sahman - first_name: A. full_name: Yates, A. last_name: Yates citation: ama: 'Parsons SG, Brown AJ, Casewell SL, et al. ZTF J021804.16+071152.93: A dead cataclysmic variable and potential solution to the missing period bouncer cataclysmic variables. Monthly Notices of the Royal Astronomical Society. 2026;547(4). doi:10.1093/mnras/stag521' apa: 'Parsons, S. G., Brown, A. J., Casewell, S. L., Littlefair, S. P., van Roestel, J. C., Rebassa-Mansergas, A., … Yates, A. (2026). ZTF J021804.16+071152.93: A dead cataclysmic variable and potential solution to the missing period bouncer cataclysmic variables. Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/stag521' chicago: 'Parsons, S. G., A. J. Brown, S. L. Casewell, S. P. Littlefair, Joannes C van Roestel, A. Rebassa-Mansergas, R. Murillo-Ojeda, et al. “ZTF J021804.16+071152.93: A Dead Cataclysmic Variable and Potential Solution to the Missing Period Bouncer Cataclysmic Variables.” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2026. https://doi.org/10.1093/mnras/stag521.' ieee: 'S. G. Parsons et al., “ZTF J021804.16+071152.93: A dead cataclysmic variable and potential solution to the missing period bouncer cataclysmic variables,” Monthly Notices of the Royal Astronomical Society, vol. 547, no. 4. Oxford University Press, 2026.' ista: 'Parsons SG, Brown AJ, Casewell SL, Littlefair SP, van Roestel JC, Rebassa-Mansergas A, Murillo-Ojeda R, Zorotovic M, Schreiber MR, Bagnulo S, Stroet MA, Castro Segura N, Dhillon VS, Dyer MJ, Garbutt JA, Green MJ, Jarvis D, Kennedy MR, Kerry P, Mccormac J, Munday J, Pelisoli I, Pike E, Sahman DI, Yates A. 2026. ZTF J021804.16+071152.93: A dead cataclysmic variable and potential solution to the missing period bouncer cataclysmic variables. Monthly Notices of the Royal Astronomical Society. 547(4), stag521.' mla: 'Parsons, S. G., et al. “ZTF J021804.16+071152.93: A Dead Cataclysmic Variable and Potential Solution to the Missing Period Bouncer Cataclysmic Variables.” Monthly Notices of the Royal Astronomical Society, vol. 547, no. 4, stag521, Oxford University Press, 2026, doi:10.1093/mnras/stag521.' short: S.G. Parsons, A.J. Brown, S.L. Casewell, S.P. Littlefair, J.C. van Roestel, A. Rebassa-Mansergas, R. Murillo-Ojeda, M. Zorotovic, M.R. Schreiber, S. Bagnulo, M.A. Stroet, N. Castro Segura, V.S. Dhillon, M.J. Dyer, J.A. Garbutt, M.J. Green, D. Jarvis, M.R. Kennedy, P. Kerry, J. Mccormac, J. Munday, I. Pelisoli, E. Pike, D.I. Sahman, A. Yates, Monthly Notices of the Royal Astronomical Society 547 (2026). date_created: 2026-05-03T22:01:37Z date_published: 2026-04-01T00:00:00Z date_updated: 2026-05-07T07:51:58Z day: '01' ddc: - '520' department: - _id: IlCa doi: 10.1093/mnras/stag521 external_id: arxiv: - '2603.12888' file: - access_level: open_access checksum: a64094199db4dedb12fc121b7c65fe97 content_type: application/pdf creator: dernst date_created: 2026-05-07T07:51:06Z date_updated: 2026-05-07T07:51:06Z file_id: '21834' file_name: 2026_MNRAS_Parsons.pdf file_size: 5955512 relation: main_file success: 1 file_date_updated: 2026-05-07T07:51:06Z has_accepted_license: '1' intvolume: ' 547' issue: '4' language: - iso: eng month: '04' oa: 1 oa_version: Published Version publication: Monthly Notices of the Royal Astronomical Society publication_identifier: eissn: - 1365-2966 issn: - 0035-8711 publication_status: published publisher: Oxford University Press quality_controlled: '1' scopus_import: '1' status: public title: 'ZTF J021804.16+071152.93: A dead cataclysmic variable and potential solution to the missing period bouncer cataclysmic variables' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 547 year: '2026' ... --- OA_place: repository OA_type: green _id: '21781' abstract: - lang: eng text: "Given a set A of n points (vertices) in general position in the plane, the complete geometric graph \r\nKn[A] consists of all (n2) segments (edges) between the elements of A. It is known that the edge set of every complete geometric graph on n vertices can be partitioned into O(n3∕2) crossing-free paths (or matchings). We strengthen this result under various additional assumptions on the point set. In particular, we prove that for a set A of n randomly selected points, uniformly distributed in [0,1]2, with probability tending to 1 as n→∞, the edge set of Kn[A] can be covered by O(nlogn) crossing-free paths and by O(n√logn) crossing-free matchings. On the other hand, we construct n-element point sets such that covering the edge set of Kn[A] requires a quadratic number of monotone paths." acknowledgement: "Research partially supported by ERC Advanced Grant \"GeoScape\", no. 882971 and\r\nHungarian NKFIH grant no. K-131529. Work by the third author is supported by EPSRC grant\r\nEP/X013642/1. Work by the third author is partially supported by the European Research Council (ERC), grant no. 788183, and by the Wittgenstein Prize, Austrian Science Fund (FWF), grant no. Z 342-N31." article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Adrian full_name: Dumitrescu, Adrian last_name: Dumitrescu - first_name: János full_name: Pach, János last_name: Pach - first_name: Morteza full_name: Saghafian, Morteza id: f86f7148-b140-11ec-9577-95435b8df824 last_name: Saghafian - first_name: Alex full_name: Scott, Alex last_name: Scott citation: ama: Dumitrescu A, Pach J, Saghafian M, Scott A. Covering complete geometric graphs by monotone paths. Combinatorics and Number Theory. 2026;15(1):73-82. doi:10.2140/cnt.2026.15.73 apa: Dumitrescu, A., Pach, J., Saghafian, M., & Scott, A. (2026). Covering complete geometric graphs by monotone paths. Combinatorics and Number Theory. Mathematical Sciences Publishers. https://doi.org/10.2140/cnt.2026.15.73 chicago: Dumitrescu, Adrian, János Pach, Morteza Saghafian, and Alex Scott. “Covering Complete Geometric Graphs by Monotone Paths.” Combinatorics and Number Theory. Mathematical Sciences Publishers, 2026. https://doi.org/10.2140/cnt.2026.15.73. ieee: A. Dumitrescu, J. Pach, M. Saghafian, and A. Scott, “Covering complete geometric graphs by monotone paths,” Combinatorics and Number Theory, vol. 15, no. 1. Mathematical Sciences Publishers, pp. 73–82, 2026. ista: Dumitrescu A, Pach J, Saghafian M, Scott A. 2026. Covering complete geometric graphs by monotone paths. Combinatorics and Number Theory. 15(1), 73–82. mla: Dumitrescu, Adrian, et al. “Covering Complete Geometric Graphs by Monotone Paths.” Combinatorics and Number Theory, vol. 15, no. 1, Mathematical Sciences Publishers, 2026, pp. 73–82, doi:10.2140/cnt.2026.15.73. short: A. Dumitrescu, J. Pach, M. Saghafian, A. Scott, Combinatorics and Number Theory 15 (2026) 73–82. date_created: 2026-05-03T22:01:37Z date_published: 2026-04-17T00:00:00Z date_updated: 2026-05-07T07:45:24Z day: '17' department: - _id: HeEd doi: 10.2140/cnt.2026.15.73 ec_funded: 1 external_id: arxiv: - '2507.10840' intvolume: ' 15' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2507.10840 month: '04' oa: 1 oa_version: Preprint page: 73-82 project: - _id: 266A2E9E-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '788183' name: Alpha Shape Theory Extended - _id: 268116B8-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: Z00342 name: Mathematics, Computer Science publication: Combinatorics and Number Theory publication_identifier: eissn: - 2996-220X issn: - 2996-2196 publication_status: published publisher: Mathematical Sciences Publishers quality_controlled: '1' scopus_import: '1' status: public title: Covering complete geometric graphs by monotone paths type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 15 year: '2026' ... --- OA_place: repository OA_type: green _id: '21798' abstract: - lang: eng text: 'Phase singularities—points carrying quantized topological charge—are universal features found across diverse wave systems from superfluids and superconductors to acoustic and optical fields1,2,3,4. Ensembles of these singularities exhibit distance correlations resembling particles in liquids5,6,7,8, extensively studied for their role in exotic material phases9,10,11. By contrast, the full correlations in phase space that govern the system evolution have remained unexplored and experimentally inaccessible. Here we directly measure the ultrafast dynamics of optical singularity ensembles, capturing their full phase-space correlations, presenting the joint distance–velocity distribution. Our observations show a breakdown of the particle-singularity analogy12: phase singularities accelerate towards formally divergent velocities in the moment before annihilation7,13,14, indicated by measurements of velocities exceeding the speed of light. These apparent superluminal velocities are paradoxically amplified by the slow group velocity of hyperbolic phonon polaritons in our material platform, hexagonal boron nitride membranes15,16,17,18,19. We demonstrate these phenomena using combined hardware and algorithmic advances in ultrafast electron microscopy18,20,21,22,23,24,25, achieving spatial and temporal resolutions, each an order of magnitude below the polaritonic wavelength and cycle period. Our findings deepen our understanding of phase singularities and their universality, enabling to probe topological defect dynamics at previously unattainable timescales.' article_processing_charge: No article_type: original arxiv: 1 author: - first_name: T. full_name: Bucher, T. last_name: Bucher - first_name: A. full_name: Gorlach, A. last_name: Gorlach - first_name: A. full_name: Niedermayr, A. last_name: Niedermayr - first_name: Q. full_name: Yan, Q. last_name: Yan - first_name: H. full_name: Nahari, H. last_name: Nahari - first_name: K. full_name: Wang, K. last_name: Wang - first_name: R. full_name: Ruimy, R. last_name: Ruimy - first_name: Y. full_name: Adiv, Y. last_name: Adiv - first_name: M. full_name: Yannai, M. last_name: Yannai - first_name: T. L. full_name: Abudi, T. L. last_name: Abudi - first_name: E. full_name: Janzen, E. last_name: Janzen - first_name: C. full_name: Spaegele, C. last_name: Spaegele - first_name: Charles full_name: Roques-Carmes, Charles id: e2e68fc9-6505-11ef-a541-eb4e72cc3e82 last_name: Roques-Carmes - first_name: J. H. full_name: Edgar, J. H. last_name: Edgar - first_name: F. H. L. full_name: Koppens, F. H. L. last_name: Koppens - first_name: G. M. full_name: Vanacore, G. M. last_name: Vanacore - first_name: H. full_name: H. Sheinfux, H. last_name: H. Sheinfux - first_name: S. full_name: Tsesses, S. last_name: Tsesses - first_name: I. full_name: Kaminer, I. last_name: Kaminer citation: ama: Bucher T, Gorlach A, Niedermayr A, et al. Superluminal correlations in ensembles of optical phase singularities. Nature. 2026;651(8107):920-926. doi:10.1038/s41586-026-10209-z apa: Bucher, T., Gorlach, A., Niedermayr, A., Yan, Q., Nahari, H., Wang, K., … Kaminer, I. (2026). Superluminal correlations in ensembles of optical phase singularities. Nature. Springer Nature. https://doi.org/10.1038/s41586-026-10209-z chicago: Bucher, T., A. Gorlach, A. Niedermayr, Q. Yan, H. Nahari, K. Wang, R. Ruimy, et al. “Superluminal Correlations in Ensembles of Optical Phase Singularities.” Nature. Springer Nature, 2026. https://doi.org/10.1038/s41586-026-10209-z. ieee: T. Bucher et al., “Superluminal correlations in ensembles of optical phase singularities,” Nature, vol. 651, no. 8107. Springer Nature, pp. 920–926, 2026. ista: Bucher T, Gorlach A, Niedermayr A, Yan Q, Nahari H, Wang K, Ruimy R, Adiv Y, Yannai M, Abudi TL, Janzen E, Spaegele C, Roques-Carmes C, Edgar JH, Koppens FHL, Vanacore GM, H. Sheinfux H, Tsesses S, Kaminer I. 2026. Superluminal correlations in ensembles of optical phase singularities. Nature. 651(8107), 920–926. mla: Bucher, T., et al. “Superluminal Correlations in Ensembles of Optical Phase Singularities.” Nature, vol. 651, no. 8107, Springer Nature, 2026, pp. 920–26, doi:10.1038/s41586-026-10209-z. short: T. Bucher, A. Gorlach, A. Niedermayr, Q. Yan, H. Nahari, K. Wang, R. Ruimy, Y. Adiv, M. Yannai, T.L. Abudi, E. Janzen, C. Spaegele, C. Roques-Carmes, J.H. Edgar, F.H.L. Koppens, G.M. Vanacore, H. H. Sheinfux, S. Tsesses, I. Kaminer, Nature 651 (2026) 920–926. date_created: 2026-05-05T11:05:31Z date_published: 2026-03-25T00:00:00Z date_updated: 2026-05-05T11:10:07Z day: '25' doi: 10.1038/s41586-026-10209-z extern: '1' external_id: arxiv: - '2509.17675' intvolume: ' 651' issue: '8107' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2509.17675 month: '03' oa: 1 oa_version: Preprint page: 920-926 publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: Superluminal correlations in ensembles of optical phase singularities type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 651 year: '2026' ... --- OA_place: repository OA_type: green _id: '21800' abstract: - lang: eng text: 'LAMMPS input scripts to simulate toroidal vesicles composed of pure bolalipid membranes and archaeal mixture membranes for the following publication: "Cracking donuts and sorting lipids: geometry controls archaeal membrane stability and lipid organization" by Felix Frey, Miguel Amaral, and Andela Saric.' article_processing_charge: No author: - first_name: Felix F full_name: Frey, Felix F id: a0270b37-8f1a-11ec-95c7-8e710c59a4f3 last_name: Frey orcid: 0000-0001-8501-6017 - first_name: Miguel full_name: Santana de Freitas Amaral, Miguel id: 4f2d02dd-47a9-11ec-ad10-82820ed3f501 last_name: Santana de Freitas Amaral - first_name: Anđela full_name: Šarić, Anđela id: bf63d406-f056-11eb-b41d-f263a6566d8b last_name: Šarić orcid: 0000-0002-7854-2139 citation: ama: 'Frey FF, Santana de Freitas Amaral M, Šarić A. Cracking donuts and sorting lipids: Geometry controls archaeal membrane stability and lipid organization. 2026. doi:10.5281/ZENODO.18772086' apa: 'Frey, F. F., Santana de Freitas Amaral, M., & Šarić, A. (2026). Cracking donuts and sorting lipids: Geometry controls archaeal membrane stability and lipid organization. Zenodo. https://doi.org/10.5281/ZENODO.18772086' chicago: 'Frey, Felix F, Miguel Santana de Freitas Amaral, and Anđela Šarić. “Cracking Donuts and Sorting Lipids: Geometry Controls Archaeal Membrane Stability and Lipid Organization.” Zenodo, 2026. https://doi.org/10.5281/ZENODO.18772086.' ieee: 'F. F. Frey, M. Santana de Freitas Amaral, and A. Šarić, “Cracking donuts and sorting lipids: Geometry controls archaeal membrane stability and lipid organization.” Zenodo, 2026.' ista: 'Frey FF, Santana de Freitas Amaral M, Šarić A. 2026. Cracking donuts and sorting lipids: Geometry controls archaeal membrane stability and lipid organization, Zenodo, 10.5281/ZENODO.18772086.' mla: 'Frey, Felix F., et al. Cracking Donuts and Sorting Lipids: Geometry Controls Archaeal Membrane Stability and Lipid Organization. Zenodo, 2026, doi:10.5281/ZENODO.18772086.' short: F.F. Frey, M. Santana de Freitas Amaral, A. Šarić, (2026). corr_author: '1' date_created: 2026-05-05T12:11:52Z date_published: 2026-02-25T00:00:00Z date_updated: 2026-05-05T12:40:41Z day: '25' ddc: - '540' department: - _id: AnSa doi: 10.5281/ZENODO.18772086 main_file_link: - open_access: '1' url: https://doi.org/10.5281/ZENODO.18772086 month: '02' oa: 1 oa_version: Published Version publisher: Zenodo related_material: record: - id: '21748' relation: used_in_publication status: public status: public title: 'Cracking donuts and sorting lipids: Geometry controls archaeal membrane stability and lipid organization' type: research_data_reference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2026' ...