--- APC_amount: 3197,23 EUR DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '18481' abstract: - lang: eng text: A tight regulation of morphogen production is key for morphogen gradient formation and thereby for reproducible and organised organ development. Although many genetic interactions involved in the establishment of morphogen production domains are known, the biophysical mechanisms of morphogen source formation are poorly understood. Here we addressed this by focusing on the morphogen Sonic hedgehog (Shh) in the vertebrate neural tube. Shh is produced by the adjacently located notochord and by the floor plate of the neural tube. Using a data-constrained computational screen, we identified different possible mechanisms by which floor plate formation can occur, only one of which is consistent with experimental data. In this mechanism, the floor plate is established rapidly in response to Shh from the notochord and the dynamics of regulatory interactions within the neural tube. In this process, uniform activators and Shh-dependent repressors are key for establishing the floor plate size. Subsequently, the floor plate becomes insensitive to Shh and increases in size due to tissue growth, leading to scaling of the floor plate with neural tube size. In turn, this results in scaling of the Shh amplitude with tissue growth. Thus, this mechanism ensures a separation of time scales in floor plate formation, so that the floor plate domain becomes growth-dependent after an initial rapid establishment phase. Our study raises the possibility that the time scale separation between specification and growth might be a common strategy for scaling the morphogen gradient amplitude in growing organs. The model that we developed provides a new opportunity for quantitative studies of morphogen source formation in growing tissues. acknowledgement: "We thank Martina Greunz-Schindler for technical support, and Thomas Minchington and James Briscoe for comments on the manuscript.\r\nRDJGH, MM and MZ were supported by a grant from the Priority Research Area DigiWorld\r\nunder the Strategic Programme Excellence Initiative at Jagiellonian University. The research\r\nwas supported by the Polish National Agency for Academic Exchange, PN/PPO/2018/1/00011/U/00001 which paid the salary of MM and MZ up to Feb 2023. The research received support from National Science Center, Poland, 2021/42/E/NZ2/00188 which paid salary of MZ. Work in the AK labis supported by ISTA to KK and AK, the European\r\nResearch Council under Horizon Europe: grant 101044579 to AK, and Austrian Science Fund\r\n(FWF): Grant DOI 10.55776/F78 to AK. The salaries of AK and KK were paid by ISTA. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript." article_number: e1012508 article_processing_charge: No article_type: original author: - first_name: Richard D.J.G. full_name: Ho, Richard D.J.G. last_name: Ho - first_name: Kasumi full_name: Kishi, Kasumi id: 3065DFC4-F248-11E8-B48F-1D18A9856A87 last_name: Kishi orcid: 0000-0001-6060-4795 - first_name: Maciej full_name: Majka, Maciej last_name: Majka - first_name: Anna full_name: Kicheva, Anna id: 3959A2A0-F248-11E8-B48F-1D18A9856A87 last_name: Kicheva orcid: 0000-0003-4509-4998 - first_name: Marcin P full_name: Zagórski, Marcin P id: 343DA0DC-F248-11E8-B48F-1D18A9856A87 last_name: Zagórski orcid: 0000-0001-7896-7762 citation: ama: Ho RDJG, Kishi K, Majka M, Kicheva A, Zagórski MP. Dynamics of morphogen source formation in a growing tissue. PLoS Computational Biology. 2024;20. doi:10.1371/journal.pcbi.1012508 apa: Ho, R. D. J. G., Kishi, K., Majka, M., Kicheva, A., & Zagórski, M. P. (2024). Dynamics of morphogen source formation in a growing tissue. PLoS Computational Biology. Public Library of Science. https://doi.org/10.1371/journal.pcbi.1012508 chicago: Ho, Richard D.J.G., Kasumi Kishi, Maciej Majka, Anna Kicheva, and Marcin P Zagórski. “Dynamics of Morphogen Source Formation in a Growing Tissue.” PLoS Computational Biology. Public Library of Science, 2024. https://doi.org/10.1371/journal.pcbi.1012508. ieee: R. D. J. G. Ho, K. Kishi, M. Majka, A. Kicheva, and M. P. Zagórski, “Dynamics of morphogen source formation in a growing tissue,” PLoS Computational Biology, vol. 20. Public Library of Science, 2024. ista: Ho RDJG, Kishi K, Majka M, Kicheva A, Zagórski MP. 2024. Dynamics of morphogen source formation in a growing tissue. PLoS Computational Biology. 20, e1012508. mla: Ho, Richard D. J. G., et al. “Dynamics of Morphogen Source Formation in a Growing Tissue.” PLoS Computational Biology, vol. 20, e1012508, Public Library of Science, 2024, doi:10.1371/journal.pcbi.1012508. short: R.D.J.G. Ho, K. Kishi, M. Majka, A. Kicheva, M.P. Zagórski, PLoS Computational Biology 20 (2024). corr_author: '1' das_tickbox: '1' dataavailabilitystatement: Custom software in C++ used to run the computational screen is available as S1 Simulation code. Custom script in Python used to analyze Shh profiles is available as S1 Script code. All data are in the manuscript and/or supporting information files date_created: 2024-10-27T23:01:45Z date_published: 2024-10-14T00:00:00Z date_updated: 2026-10-16T08:31:15Z day: '14' ddc: - '570' department: - _id: AnKi doi: 10.1371/journal.pcbi.1012508 external_id: isi: - '001331700300003' pmid: - '39401260' file: - access_level: open_access checksum: 42fa714459943cb3961b40fab8fd82c8 content_type: application/pdf creator: dernst date_created: 2024-10-29T11:59:09Z date_updated: 2024-10-29T11:59:09Z file_id: '18487' file_name: 2024_PloSComBio_Ho.pdf file_size: 3732443 relation: main_file success: 1 file_date_updated: 2024-10-29T11:59:09Z fulldoi: https://doi.org/10.1371/journal.pcbi.1012508 has_accepted_license: '1' intvolume: ' 20' isi: 1 language: - iso: eng month: '10' oa: 1 oa_version: Published Version pmid: 1 project: - _id: bd7e737f-d553-11ed-ba76-d69ffb5ee3aa grant_number: '101044579' name: Mechanisms of tissue size regulation in spinal cord development - _id: 059DF620-7A3F-11EA-A408-12923DDC885E grant_number: F7802 name: Stem Cell Modulation in Neural Development and Regeneration/ P02-Morphogen control of growth and pattern in the spinal cord publication: PLoS Computational Biology publication_identifier: eissn: - 1553-7358 issn: - 1553-734X publication_status: published publisher: Public Library of Science quality_controlled: '1' related_material: record: - id: '20393' relation: dissertation_contains status: public researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: yes title: Dynamics of morphogen source formation in a growing tissue tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 20 year: '2024' ... --- OA_place: publisher OA_type: hybrid _id: '18554' abstract: - lang: eng text: We prove the Eigenstate Thermalization Hypothesis for general Wigner-type matrices in the bulk of the self-consistent spectrum, with optimal control on the fluctuations for obs ervables of arbitrary rank. As the main technical ingredient, we prove rank-uniform optimal local laws for one and two resolvents of a Wigner-type matrix with regular observables. Our results hold under very general conditions on the variance profile, even allowing many vanishing entries, demonstrating that Eigenstate Thermalization occurs robustly across a diverse class of random matrix ensembles, for which the underlying quantum system has a non-trivial spatial structure. acknowledgement: Open access funding provided by Institute of Science and Technology (IST Austria). article_number: '282' article_processing_charge: Yes (via OA deal) article_type: original arxiv: 1 author: - first_name: László full_name: Erdös, László id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 - first_name: Volodymyr full_name: Riabov, Volodymyr id: 1949f904-edfb-11eb-afb5-e2dfddabb93b last_name: Riabov citation: ama: Erdös L, Riabov V. Eigenstate Thermalization Hypothesis for Wigner-type matrices. Communications in Mathematical Physics. 2024;405(12). doi:10.1007/s00220-024-05143-y apa: Erdös, L., & Riabov, V. (2024). Eigenstate Thermalization Hypothesis for Wigner-type matrices. Communications in Mathematical Physics. Springer Nature. https://doi.org/10.1007/s00220-024-05143-y chicago: Erdös, László, and Volodymyr Riabov. “Eigenstate Thermalization Hypothesis for Wigner-Type Matrices.” Communications in Mathematical Physics. Springer Nature, 2024. https://doi.org/10.1007/s00220-024-05143-y. ieee: L. Erdös and V. Riabov, “Eigenstate Thermalization Hypothesis for Wigner-type matrices,” Communications in Mathematical Physics, vol. 405, no. 12. Springer Nature, 2024. ista: Erdös L, Riabov V. 2024. Eigenstate Thermalization Hypothesis for Wigner-type matrices. Communications in Mathematical Physics. 405(12), 282. mla: Erdös, László, and Volodymyr Riabov. “Eigenstate Thermalization Hypothesis for Wigner-Type Matrices.” Communications in Mathematical Physics, vol. 405, no. 12, 282, Springer Nature, 2024, doi:10.1007/s00220-024-05143-y. short: L. Erdös, V. Riabov, Communications in Mathematical Physics 405 (2024). corr_author: '1' das_tickbox: '1' dataavailabilitystatement: There is no data associated to this work. date_created: 2024-11-17T23:01:46Z date_published: 2024-12-01T00:00:00Z date_updated: 2026-10-16T08:34:30Z day: '01' ddc: - '510' department: - _id: LaEr doi: 10.1007/s00220-024-05143-y external_id: arxiv: - '2403.10359' isi: - '001348943900004' pmid: - '39526190' file: - access_level: open_access checksum: c9ae0ea195bd39b8b3a630d492fb00dc content_type: application/pdf creator: dernst date_created: 2024-11-18T08:15:07Z date_updated: 2024-11-18T08:15:07Z file_id: '18562' file_name: 2024_CommMathPhysics_Erdoes.pdf file_size: 1426046 relation: main_file success: 1 file_date_updated: 2024-11-18T08:15:07Z fulldoi: https://doi.org/10.1007/s00220-024-05143-y has_accepted_license: '1' intvolume: ' 405' isi: 1 issue: '12' language: - iso: eng month: '12' oa: 1 oa_version: Published Version pmid: 1 publication: Communications in Mathematical Physics publication_identifier: eissn: - 1432-0916 issn: - 0010-3616 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: record: - id: '20575' relation: dissertation_contains status: public researchdata_availability: not applicable scopus_import: '1' status: public supplementarymaterial: yes title: Eigenstate Thermalization Hypothesis for Wigner-type matrices tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 405 year: '2024' ... --- _id: '13975' abstract: - lang: eng text: "We consider the spectrum of random Laplacian matrices of the form Ln=An−Dn where An\r\n is a real symmetric random matrix and Dn is a diagonal matrix whose entries are equal to the corresponding row sums of An. If An is a Wigner matrix with entries in the domain of attraction of a Gaussian distribution, the empirical spectral measure of Ln is known to converge to the free convolution of a semicircle distribution and a standard real Gaussian distribution. We consider real symmetric random matrices An with independent entries (up to symmetry) whose row sums converge to a purely non-Gaussian infinitely divisible distribution, which fall into the class of Lévy–Khintchine random matrices first introduced by Jung [Trans Am Math Soc, 370, (2018)]. Our main result shows that the empirical spectral measure of Ln converges almost surely to a deterministic limit. A key step in the proof is to use the purely non-Gaussian nature of the row sums to build a random operator to which Ln converges in an appropriate sense. This operator leads to a recursive distributional equation uniquely describing the Stieltjes transform of the limiting empirical spectral measure." acknowledgement: "The first author thanks Yizhe Zhu for pointing out reference [30]. We thank David Renfrew for comments on an earlier draft. We thank the anonymous referee for a careful reading and helpful comments.\r\nOpen access funding provided by Institute of Science and Technology (IST Austria)." article_processing_charge: Yes (via OA deal) article_type: original arxiv: 1 author: - first_name: Andrew J full_name: Campbell, Andrew J id: 582b06a9-1f1c-11ee-b076-82ffce00dde4 last_name: Campbell - first_name: Sean full_name: O’Rourke, Sean last_name: O’Rourke citation: ama: Campbell AJ, O’Rourke S. Spectrum of Lévy–Khintchine random laplacian matrices. Journal of Theoretical Probability. 2024;37:933-973. doi:10.1007/s10959-023-01275-4 apa: Campbell, A. J., & O’Rourke, S. (2024). Spectrum of Lévy–Khintchine random laplacian matrices. Journal of Theoretical Probability. Springer Nature. https://doi.org/10.1007/s10959-023-01275-4 chicago: Campbell, Andrew J, and Sean O’Rourke. “Spectrum of Lévy–Khintchine Random Laplacian Matrices.” Journal of Theoretical Probability. Springer Nature, 2024. https://doi.org/10.1007/s10959-023-01275-4. ieee: A. J. Campbell and S. O’Rourke, “Spectrum of Lévy–Khintchine random laplacian matrices,” Journal of Theoretical Probability, vol. 37. Springer Nature, pp. 933–973, 2024. ista: Campbell AJ, O’Rourke S. 2024. Spectrum of Lévy–Khintchine random laplacian matrices. Journal of Theoretical Probability. 37, 933–973. mla: Campbell, Andrew J., and Sean O’Rourke. “Spectrum of Lévy–Khintchine Random Laplacian Matrices.” Journal of Theoretical Probability, vol. 37, Springer Nature, 2024, pp. 933–73, doi:10.1007/s10959-023-01275-4. short: A.J. Campbell, S. O’Rourke, Journal of Theoretical Probability 37 (2024) 933–973. corr_author: '1' das_tickbox: '1' dataavailabilitystatement: All data generated or analyzed during this study are included in this published article. date_created: 2023-08-06T22:01:13Z date_published: 2024-03-01T00:00:00Z date_updated: 2026-10-16T08:30:34Z day: '01' ddc: - '510' department: - _id: LaEr doi: 10.1007/s10959-023-01275-4 external_id: arxiv: - '2210.07927' isi: - '001038341000001' file: - access_level: open_access checksum: f7793d313104c70422140c5e6494c779 content_type: application/pdf creator: dernst date_created: 2024-07-22T09:41:21Z date_updated: 2024-07-22T09:41:21Z file_id: '17300' file_name: 2024_JourTheorProbab_Campbell.pdf file_size: 555070 relation: main_file success: 1 file_date_updated: 2024-07-22T09:41:21Z fulldoi: https://doi.org/10.1007/s10959-023-01275-4 has_accepted_license: '1' intvolume: ' 37' isi: 1 language: - iso: eng month: '03' oa: 1 oa_version: Published Version page: 933-973 publication: Journal of Theoretical Probability publication_identifier: eissn: - 1572-9230 issn: - 0894-9840 publication_status: published publisher: Springer Nature quality_controlled: '1' researchdata_availability: yes (supplementary data) scopus_import: '1' status: public supplementarymaterial: yes title: Spectrum of Lévy–Khintchine random laplacian matrices tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 37 year: '2024' ... --- _id: '17281' abstract: - lang: eng text: We extend the free convolution of Brown measures of R-diagonal elements introduced by Kösters and Tikhomirov [ 28] to fractional powers. We then show how this fractional free convolution arises naturally when studying the roots of random polynomials with independent coefficients under repeated differentiation. When the proportion of derivatives to the degree approaches one, we establish central limit theorem-type behavior and discuss stable distributions. acknowledgement: This work was supported by the National Science Foundation [Grant No. DMS-2143142 to S.O.]; and the European Research Council [Grant No. 101020331].The third author acknowledges the support of the University of Colorado Boulder, where a portion of this work was completed. The authors thank Martin Auer, Vadim Gorin, Brian Hall, and Noah Williams for comments, corrections, and references. The authors also wish to thank the anonymous referees for useful feedback and corrections. article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Andrew J full_name: Campbell, Andrew J id: 582b06a9-1f1c-11ee-b076-82ffce00dde4 last_name: Campbell - first_name: Sean full_name: O'Rourke, Sean last_name: O'Rourke - first_name: David T full_name: Renfrew, David T id: 4845BF6A-F248-11E8-B48F-1D18A9856A87 last_name: Renfrew orcid: 0000-0003-3493-121X citation: ama: Campbell AJ, O’Rourke S, Renfrew DT. The fractional free convolution of R-diagonal elements and random polynomials under repeated differentiation. International Mathematics Research Notices. 2024;2024(13):10189-10218. doi:10.1093/imrn/rnae062 apa: Campbell, A. J., O’Rourke, S., & Renfrew, D. T. (2024). The fractional free convolution of R-diagonal elements and random polynomials under repeated differentiation. International Mathematics Research Notices. Oxford University Press. https://doi.org/10.1093/imrn/rnae062 chicago: Campbell, Andrew J, Sean O’Rourke, and David T Renfrew. “The Fractional Free Convolution of R-Diagonal Elements and Random Polynomials under Repeated Differentiation.” International Mathematics Research Notices. Oxford University Press, 2024. https://doi.org/10.1093/imrn/rnae062. ieee: A. J. Campbell, S. O’Rourke, and D. T. Renfrew, “The fractional free convolution of R-diagonal elements and random polynomials under repeated differentiation,” International Mathematics Research Notices, vol. 2024, no. 13. Oxford University Press, pp. 10189–10218, 2024. ista: Campbell AJ, O’Rourke S, Renfrew DT. 2024. The fractional free convolution of R-diagonal elements and random polynomials under repeated differentiation. International Mathematics Research Notices. 2024(13), 10189–10218. mla: Campbell, Andrew J., et al. “The Fractional Free Convolution of R-Diagonal Elements and Random Polynomials under Repeated Differentiation.” International Mathematics Research Notices, vol. 2024, no. 13, Oxford University Press, 2024, pp. 10189–218, doi:10.1093/imrn/rnae062. short: A.J. Campbell, S. O’Rourke, D.T. Renfrew, International Mathematics Research Notices 2024 (2024) 10189–10218. corr_author: '1' das_tickbox: '0' date_created: 2024-07-21T22:01:01Z date_published: 2024-07-01T00:00:00Z date_updated: 2026-10-16T08:32:45Z day: '01' ddc: - '510' department: - _id: LaEr doi: 10.1093/imrn/rnae062 external_id: isi: - '001198019500001' file: - access_level: open_access checksum: f36a7dbf53f23d5833db711052e69b49 content_type: application/pdf creator: dernst date_created: 2024-07-22T06:40:19Z date_updated: 2024-07-22T06:40:19Z file_id: '17288' file_name: 2024_IMRN_Campbell.pdf file_size: 1233508 relation: main_file success: 1 file_date_updated: 2024-07-22T06:40:19Z fulldoi: https://doi.org/10.1093/imrn/rnae062 has_accepted_license: '1' intvolume: ' 2024' isi: 1 issue: '13' language: - iso: eng month: '07' oa: 1 oa_version: Published Version page: 10189-10218 publication: International Mathematics Research Notices publication_identifier: eissn: - 1687-0247 issn: - 1073-7928 publication_status: published publisher: Oxford University Press quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: yes title: The fractional free convolution of R-diagonal elements and random polynomials under repeated differentiation tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 2024 year: '2024' ... --- _id: '14408' abstract: - lang: eng text: "We prove that the mesoscopic linear statistics ∑if(na(σi−z0)) of the eigenvalues {σi}i of large n×n non-Hermitian random matrices with complex centred i.i.d. entries are asymptotically Gaussian for any H20-functions f around any point z0 in the bulk of the spectrum on any mesoscopic scale 0Probability Theory and Related Fields. 2024;188:1131-1182. doi:10.1007/s00440-023-01229-1 apa: Cipolloni, G., Erdös, L., & Schröder, D. J. (2024). Mesoscopic central limit theorem for non-Hermitian random matrices. Probability Theory and Related Fields. Springer Nature. https://doi.org/10.1007/s00440-023-01229-1 chicago: Cipolloni, Giorgio, László Erdös, and Dominik J Schröder. “Mesoscopic Central Limit Theorem for Non-Hermitian Random Matrices.” Probability Theory and Related Fields. Springer Nature, 2024. https://doi.org/10.1007/s00440-023-01229-1. ieee: G. Cipolloni, L. Erdös, and D. J. Schröder, “Mesoscopic central limit theorem for non-Hermitian random matrices,” Probability Theory and Related Fields, vol. 188. Springer Nature, pp. 1131–1182, 2024. ista: Cipolloni G, Erdös L, Schröder DJ. 2024. Mesoscopic central limit theorem for non-Hermitian random matrices. Probability Theory and Related Fields. 188, 1131–1182. mla: Cipolloni, Giorgio, et al. “Mesoscopic Central Limit Theorem for Non-Hermitian Random Matrices.” Probability Theory and Related Fields, vol. 188, Springer Nature, 2024, pp. 1131–82, doi:10.1007/s00440-023-01229-1. short: G. Cipolloni, L. Erdös, D.J. Schröder, Probability Theory and Related Fields 188 (2024) 1131–1182. das_tickbox: '0' date_created: 2023-10-08T22:01:17Z date_published: 2024-04-01T00:00:00Z date_updated: 2026-10-16T08:31:03Z day: '01' department: - _id: LaEr doi: 10.1007/s00440-023-01229-1 ec_funded: 1 external_id: arxiv: - '2210.12060' isi: - '001118972500001' fulldoi: https://doi.org/10.1007/s00440-023-01229-1 intvolume: ' 188' isi: 1 language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2210.12060 month: '04' oa: 1 oa_version: Preprint page: 1131-1182 project: - _id: 62796744-2b32-11ec-9570-940b20777f1d call_identifier: H2020 grant_number: '101020331' name: Random matrices beyond Wigner-Dyson-Mehta publication: Probability Theory and Related Fields publication_identifier: eissn: - 1432-2064 issn: - 0178-8051 publication_status: published publisher: Springer Nature quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: yes title: Mesoscopic central limit theorem for non-Hermitian random matrices type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 188 year: '2024' ... --- _id: '17375' abstract: - lang: eng text: We consider the spectral radius of a large random matrix X with independent, identically distributed entries. We show that its typical size is given by a precise three-term asymptotics with an optimal error term beyond the radius of the celebrated circular law. The coefficients in this asymptotics are universal but they differ from a similar asymptotics recently proved for the rightmost eigenvalue of X in Cipolloni et al., Ann. Probab. 51(6), 2192–2242 (2023). To access the more complicated spectral radius, we need to establish a new decorrelation mechanism for the low-lying singular values of X − z for different complex shift parameters z using the Dyson Brownian Motion. acknowledgement: L.E. and Y.X. were supported by the ERC Advanced Grant “RMTBeyond” Grant No. 101020331. article_number: '063302' article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Giorgio full_name: Cipolloni, Giorgio id: 42198EFA-F248-11E8-B48F-1D18A9856A87 last_name: Cipolloni orcid: 0000-0002-4901-7992 - first_name: László full_name: Erdös, László id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 - first_name: Yuanyuan full_name: Xu, Yuanyuan id: 7902bdb1-a2a4-11eb-a164-c9216f71aea3 last_name: Xu orcid: 0000-0003-1559-1205 citation: ama: Cipolloni G, Erdös L, Xu Y. Precise asymptotics for the spectral radius of a large random matrix. Journal of Mathematical Physics. 2024;65(6). doi:10.1063/5.0209705 apa: Cipolloni, G., Erdös, L., & Xu, Y. (2024). Precise asymptotics for the spectral radius of a large random matrix. Journal of Mathematical Physics. AIP Publishing. https://doi.org/10.1063/5.0209705 chicago: Cipolloni, Giorgio, László Erdös, and Yuanyuan Xu. “Precise Asymptotics for the Spectral Radius of a Large Random Matrix.” Journal of Mathematical Physics. AIP Publishing, 2024. https://doi.org/10.1063/5.0209705. ieee: G. Cipolloni, L. Erdös, and Y. Xu, “Precise asymptotics for the spectral radius of a large random matrix,” Journal of Mathematical Physics, vol. 65, no. 6. AIP Publishing, 2024. ista: Cipolloni G, Erdös L, Xu Y. 2024. Precise asymptotics for the spectral radius of a large random matrix. Journal of Mathematical Physics. 65(6), 063302. mla: Cipolloni, Giorgio, et al. “Precise Asymptotics for the Spectral Radius of a Large Random Matrix.” Journal of Mathematical Physics, vol. 65, no. 6, 063302, AIP Publishing, 2024, doi:10.1063/5.0209705. short: G. Cipolloni, L. Erdös, Y. Xu, Journal of Mathematical Physics 65 (2024). corr_author: '1' das_tickbox: '1' dataavailabilitystatement: "Data sharing is not applicable to this article as no new data were created or analyzed in this study.\r\n\r\n" date_created: 2024-08-04T22:01:22Z date_published: 2024-06-01T00:00:00Z date_updated: 2026-10-16T08:33:32Z day: '01' department: - _id: LaEr doi: 10.1063/5.0209705 ec_funded: 1 external_id: arxiv: - '2210.15643' isi: - '001252240700002' fulldoi: https://doi.org/10.1063/5.0209705 intvolume: ' 65' isi: 1 issue: '6' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2210.15643 month: '06' oa: 1 oa_version: Preprint project: - _id: 62796744-2b32-11ec-9570-940b20777f1d call_identifier: H2020 grant_number: '101020331' name: Random matrices beyond Wigner-Dyson-Mehta publication: Journal of Mathematical Physics publication_identifier: issn: - 0022-2488 publication_status: published publisher: AIP Publishing quality_controlled: '1' researchdata_availability: not applicable scopus_import: '1' status: public supplementarymaterial: yes title: Precise asymptotics for the spectral radius of a large random matrix type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 65 year: '2024' ... --- _id: '15025' abstract: - lang: eng text: We consider quadratic forms of deterministic matrices A evaluated at the random eigenvectors of a large N×N GOE or GUE matrix, or equivalently evaluated at the columns of a Haar-orthogonal or Haar-unitary random matrix. We prove that, as long as the deterministic matrix has rank much smaller than √N, the distributions of the extrema of these quadratic forms are asymptotically the same as if the eigenvectors were independent Gaussians. This reduces the problem to Gaussian computations, which we carry out in several cases to illustrate our result, finding Gumbel or Weibull limiting distributions depending on the signature of A. Our result also naturally applies to the eigenvectors of any invariant ensemble. acknowledgement: The first author was supported by the ERC Advanced Grant “RMTBeyond” No. 101020331. The second author was supported by Fulbright Austria and the Austrian Marshall Plan Foundation. article_processing_charge: No article_type: original arxiv: 1 author: - first_name: László full_name: Erdös, László id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 - first_name: Benjamin full_name: McKenna, Benjamin id: b0cc634c-d549-11ee-96c8-87338c7ad808 last_name: McKenna orcid: 0000-0003-2625-495X citation: ama: Erdös L, McKenna B. Extremal statistics of quadratic forms of GOE/GUE eigenvectors. Annals of Applied Probability. 2024;34(1B):1623-1662. doi:10.1214/23-AAP2000 apa: Erdös, L., & McKenna, B. (2024). Extremal statistics of quadratic forms of GOE/GUE eigenvectors. Annals of Applied Probability. Institute of Mathematical Statistics. https://doi.org/10.1214/23-AAP2000 chicago: Erdös, László, and Benjamin McKenna. “Extremal Statistics of Quadratic Forms of GOE/GUE Eigenvectors.” Annals of Applied Probability. Institute of Mathematical Statistics, 2024. https://doi.org/10.1214/23-AAP2000. ieee: L. Erdös and B. McKenna, “Extremal statistics of quadratic forms of GOE/GUE eigenvectors,” Annals of Applied Probability, vol. 34, no. 1B. Institute of Mathematical Statistics, pp. 1623–1662, 2024. ista: Erdös L, McKenna B. 2024. Extremal statistics of quadratic forms of GOE/GUE eigenvectors. Annals of Applied Probability. 34(1B), 1623–1662. mla: Erdös, László, and Benjamin McKenna. “Extremal Statistics of Quadratic Forms of GOE/GUE Eigenvectors.” Annals of Applied Probability, vol. 34, no. 1B, Institute of Mathematical Statistics, 2024, pp. 1623–62, doi:10.1214/23-AAP2000. short: L. Erdös, B. McKenna, Annals of Applied Probability 34 (2024) 1623–1662. corr_author: '1' das_tickbox: '0' date_created: 2024-02-25T23:00:56Z date_published: 2024-02-01T00:00:00Z date_updated: 2026-10-16T08:33:55Z day: '01' department: - _id: LaEr doi: 10.1214/23-AAP2000 ec_funded: 1 external_id: arxiv: - '2208.12206' isi: - '001163006100021' fulldoi: https://doi.org/10.1214/23-AAP2000 intvolume: ' 34' isi: 1 issue: 1B language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2208.12206 month: '02' oa: 1 oa_version: Preprint page: 1623-1662 project: - _id: 62796744-2b32-11ec-9570-940b20777f1d call_identifier: H2020 grant_number: '101020331' name: Random matrices beyond Wigner-Dyson-Mehta publication: Annals of Applied Probability publication_identifier: issn: - 1050-5164 publication_status: published publisher: Institute of Mathematical Statistics quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: yes title: Extremal statistics of quadratic forms of GOE/GUE eigenvectors type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 34 year: '2024' ... --- OA_place: publisher _id: '17164' abstract: - lang: eng text: "This thesis is structured into two parts. In the first part, we consider the random\r\nvariable X := Tr(f1(W)A1 . . . fk(W)Ak) where W is an N × N Hermitian Wigner matrix, k ∈ N, and we choose (possibly N-dependent) regular functions f1, . . . , fk as well as\r\nbounded deterministic matrices A1, . . . , Ak. In this context, we prove a functional central\r\nlimit theorem on macroscopic and mesoscopic scales, showing that the fluctuations of X\r\naround its expectation are Gaussian and that the limiting covariance structure is given\r\nby a deterministic recursion. We further give explicit error bounds in terms of the scaling\r\nof f1, . . . , fk and the number of traceless matrices among A1, . . . , Ak, thus extending\r\nthe results of Cipolloni, Erdős and Schröder [40] to products of arbitrary length k ≥ 2.\r\nAnalyzing the underlying combinatorics leads to a non-recursive formula for the variance\r\nof X as well as the covariance of X and Y := Tr(fk+1(W)Ak+1 . . . fk+ℓ(W)Ak+ℓ) of similar\r\nbuild. When restricted to polynomials, these formulas reproduce recent results of Male,\r\nMingo, Peché, and Speicher [107], showing that the underlying combinatorics of noncrossing partitions and annular non-crossing permutations continue to stay valid beyond\r\nthe setting of second-order free probability theory. As an application, we consider the\r\nfluctuation of Tr(eitW A1e\r\n−itW A2)/N around its thermal value Tr(A1) Tr(A2)/N2 when t\r\nis large and give an explicit formula for the variance.\r\nThe second part of the thesis collects three smaller projects focusing on different random\r\nmatrix models. In the first project, we show that a class of weakly perturbed Hamiltonians\r\nof the form Hλ = H0 + λW, where W is a Wigner matrix, exhibits prethermalization.\r\nThat is, the time evolution generated by Hλ relaxes to its ultimate thermal state via an\r\nintermediate prethermal state with a lifetime of order λ\r\n−2\r\n. As the main result, we obtain\r\na general relaxation formula, expressing the perturbed dynamics via the unperturbed\r\ndynamics and the ultimate thermal state. The proof relies on a two-resolvent global law\r\nfor the deformed Wigner matrix Hλ.\r\nThe second project focuses on correlated random matrices, more precisely on a correlated N × N Hermitian random matrix with a polynomially decaying metric correlation\r\nstructure. A trivial a priori bound shows that the operator norm of this model is stochastically dominated by √\r\nN. However, by calculating the trace of the moments of the matrix\r\nand using the summable decay of the cumulants, the norm estimate can be improved to a\r\nbound of order one.\r\nIn the third project, we consider a multiplicative perturbation of the form UA(t) where U\r\nis a unitary random matrix and A = diag(t, 1, ..., 1). This so-called UA model was\r\nfirst introduced by Fyodorov [73] for its applications in scattering theory. We give a\r\ngeneral description of the eigenvalue trajectories obtained by varying the parameter t and\r\nintroduce a flow of deterministic domains that separates the outlier resulting from the\r\nrank-one perturbation from the typical eigenvalues for all sub-critical timescales. The\r\nresults are obtained under generic assumptions on U that hold for various unitary random\r\nmatrices, including the circular unitary ensemble (CUE) in the original formulation of\r\nthe model." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Jana full_name: Reker, Jana id: e796e4f9-dc8d-11ea-abe3-97e26a0323e9 last_name: Reker citation: ama: 'Reker J. Central limit theorems for random matrices: From resolvents to free probability. 2024. doi:10.15479/at:ista:17164' apa: 'Reker, J. (2024). Central limit theorems for random matrices: From resolvents to free probability. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:17164' chicago: 'Reker, Jana. “Central Limit Theorems for Random Matrices: From Resolvents to Free Probability.” Institute of Science and Technology Austria, 2024. https://doi.org/10.15479/at:ista:17164.' ieee: 'J. Reker, “Central limit theorems for random matrices: From resolvents to free probability,” Institute of Science and Technology Austria, 2024.' ista: 'Reker J. 2024. Central limit theorems for random matrices: From resolvents to free probability. Institute of Science and Technology Austria.' mla: 'Reker, Jana. Central Limit Theorems for Random Matrices: From Resolvents to Free Probability. Institute of Science and Technology Austria, 2024, doi:10.15479/at:ista:17164.' short: 'J. Reker, Central Limit Theorems for Random Matrices: From Resolvents to Free Probability, Institute of Science and Technology Austria, 2024.' corr_author: '1' das_tickbox: '0' date_created: 2024-06-24T11:23:29Z date_published: 2024-06-26T00:00:00Z date_updated: 2026-10-16T08:35:03Z day: '26' ddc: - '519' degree_awarded: PhD department: - _id: GradSch - _id: LaEr doi: 10.15479/at:ista:17164 doi_confirm: '1' ec_funded: 1 file: - access_level: open_access checksum: fb16d86e1f2753dc3a9e14d2bdfd84cd content_type: application/pdf creator: jreker date_created: 2024-06-26T12:39:36Z date_updated: 2024-06-26T12:44:53Z file_id: '17176' file_name: ISTA_Thesis_JReker.pdf file_size: 2783027 relation: main_file - access_level: closed checksum: cb1e54009d47c1dcf5b866c4566fa27f content_type: application/zip creator: jreker date_created: 2024-06-26T12:39:42Z date_updated: 2024-06-26T12:44:53Z file_id: '17177' file_name: ISTA_Thesis_JReker_SourceFiles.zip file_size: 3054878 relation: source_file file_date_updated: 2024-06-26T12:44:53Z fulldoi: https://doi.org/10.15479/at:ista:17164 has_accepted_license: '1' keyword: - Random Matrices - Spectrum - Central Limit Theorem - Resolvent - Free Probability language: - iso: eng license: https://creativecommons.org/licenses/by-nc-sa/4.0/ month: '06' oa: 1 oa_version: Published Version page: '206' project: - _id: 62796744-2b32-11ec-9570-940b20777f1d call_identifier: H2020 grant_number: '101020331' name: Random matrices beyond Wigner-Dyson-Mehta publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '17173' relation: part_of_dissertation status: public - id: '11135' relation: part_of_dissertation status: public - id: '17174' relation: part_of_dissertation status: public - id: '17047' relation: part_of_dissertation status: public - id: '17154' relation: part_of_dissertation status: public researchdata_availability: no status: public supervisor: - first_name: László full_name: Erdös, László id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 supplementarymaterial: no title: 'Central limit theorems for random matrices: From resolvents to free probability' tmp: image: /images/cc_by_nc_sa.png legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) short: CC BY-NC-SA (4.0) type: dissertation user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 year: '2024' ... --- OA_place: publisher OA_type: hybrid _id: '17049' abstract: - lang: eng text: We consider large non-Hermitian NxN matrices with an additive independent, identically distributed (i.i.d.) noise for each matrix elements. We show that already a small noise of variance 1/N completely thermalises the bulk singular vectors, in particular they satisfy the strong form of Quantum Unique Ergodicity (QUE) with an optimal speed of convergence. In physics terms, we thus extend the Eigenstate Thermalisation Hypothesis, formulated originally by Deutsch [34] and proven for Wigner matrices in [23], to arbitrary non-Hermitian matrices with an i.i.d. noise. As a consequence we obtain an optimal lower bound on the diagonal overlaps of the corresponding non-Hermitian eigenvectors. This quantity, also known as the (square of the) eigenvalue condition number measuring the sensitivity of the eigenvalue to small perturbations, has notoriously escaped rigorous treatment beyond the explicitly computable Ginibre ensemble apart from the very recent upper bounds given in [7] and [45]. As a key tool, we develop a new systematic decomposition of general observables in random matrix theory that governs the size of products of resolvents with deterministic matrices in between. acknowledgement: "Supported by ERC Advanced Grant “RMTBeyond” No. 101020331.\r\nSupported by the SNSF Ambizione Grant PZ00P2_209089." article_number: '110495' article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Giorgio full_name: Cipolloni, Giorgio id: 42198EFA-F248-11E8-B48F-1D18A9856A87 last_name: Cipolloni orcid: 0000-0002-4901-7992 - first_name: László full_name: Erdös, László id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 - first_name: Sven Joscha full_name: Henheik, Sven Joscha id: 31d731d7-d235-11ea-ad11-b50331c8d7fb last_name: Henheik orcid: 0000-0003-1106-327X - first_name: Dominik J full_name: Schröder, Dominik J id: 408ED176-F248-11E8-B48F-1D18A9856A87 last_name: Schröder orcid: 0000-0002-2904-1856 citation: ama: Cipolloni G, Erdös L, Henheik SJ, Schröder DJ. Optimal lower bound on eigenvector overlaps for non-Hermitian random matrices. Journal of Functional Analysis. 2024;287(4). doi:10.1016/j.jfa.2024.110495 apa: Cipolloni, G., Erdös, L., Henheik, S. J., & Schröder, D. J. (2024). Optimal lower bound on eigenvector overlaps for non-Hermitian random matrices. Journal of Functional Analysis. Elsevier. https://doi.org/10.1016/j.jfa.2024.110495 chicago: Cipolloni, Giorgio, László Erdös, Sven Joscha Henheik, and Dominik J Schröder. “Optimal Lower Bound on Eigenvector Overlaps for Non-Hermitian Random Matrices.” Journal of Functional Analysis. Elsevier, 2024. https://doi.org/10.1016/j.jfa.2024.110495. ieee: G. Cipolloni, L. Erdös, S. J. Henheik, and D. J. Schröder, “Optimal lower bound on eigenvector overlaps for non-Hermitian random matrices,” Journal of Functional Analysis, vol. 287, no. 4. Elsevier, 2024. ista: Cipolloni G, Erdös L, Henheik SJ, Schröder DJ. 2024. Optimal lower bound on eigenvector overlaps for non-Hermitian random matrices. Journal of Functional Analysis. 287(4), 110495. mla: Cipolloni, Giorgio, et al. “Optimal Lower Bound on Eigenvector Overlaps for Non-Hermitian Random Matrices.” Journal of Functional Analysis, vol. 287, no. 4, 110495, Elsevier, 2024, doi:10.1016/j.jfa.2024.110495. short: G. Cipolloni, L. Erdös, S.J. Henheik, D.J. Schröder, Journal of Functional Analysis 287 (2024). corr_author: '1' das_tickbox: '1' dataavailabilitystatement: No data was used for the research described in the article. date_created: 2024-05-26T22:00:57Z date_published: 2024-08-15T00:00:00Z date_updated: 2026-10-16T08:36:18Z day: '15' ddc: - '510' department: - _id: LaEr doi: 10.1016/j.jfa.2024.110495 ec_funded: 1 external_id: isi: - '001325502400001' file: - access_level: open_access checksum: 07d3f73e0c56e68eb110851842c22ee0 content_type: application/pdf creator: dernst date_created: 2025-06-24T13:14:21Z date_updated: 2025-06-24T13:14:21Z file_id: '19891' file_name: 2025_JourFunctionalAnalysis_Cipolloni.pdf file_size: 1374854 relation: main_file success: 1 file_date_updated: 2025-06-24T13:14:21Z fulldoi: https://doi.org/10.1016/j.jfa.2024.110495 has_accepted_license: '1' intvolume: ' 287' isi: 1 issue: '4' language: - iso: eng month: '08' oa: 1 oa_version: Published Version project: - _id: 62796744-2b32-11ec-9570-940b20777f1d call_identifier: H2020 grant_number: '101020331' name: Random matrices beyond Wigner-Dyson-Mehta publication: Journal of Functional Analysis publication_identifier: eissn: - 1096-0783 issn: - 0022-1236 publication_status: published publisher: Elsevier quality_controlled: '1' related_material: record: - id: '19540' relation: dissertation_contains status: public researchdata_availability: not applicable scopus_import: '1' status: public supplementarymaterial: yes title: Optimal lower bound on eigenvector overlaps for non-Hermitian random matrices tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 287 year: '2024' ... --- OA_place: publisher OA_type: hybrid _id: '15378' abstract: - lang: eng text: We consider N×N non-Hermitian random matrices of the form X+A, where A is a general deterministic matrix and N−−√X consists of independent entries with zero mean, unit variance, and bounded densities. For this ensemble, we prove (i) a Wegner estimate, i.e. that the local density of eigenvalues is bounded by N1+o(1) and (ii) that the expected condition number of any bulk eigenvalue is bounded by N1+o(1); both results are optimal up to the factor No(1). The latter result complements the very recent matching lower bound obtained in [15] (arXiv:2301.03549) and improves the N-dependence of the upper bounds in [5,6,32] (arXiv:1906.11819, arXiv:2005.08930, arXiv:2005.08908). Our main ingredient, a near-optimal lower tail estimate for the small singular values of X+A−z, is of independent interest. acknowledgement: László Erdős is partially supported by ERC Advanced Grant “RMTBeyond” No. 101020331. Hong Chang Ji is supported by ERC Advanced Grant “RMTBeyond” No. 101020331. article_processing_charge: Yes (via OA deal) article_type: original arxiv: 1 author: - first_name: László full_name: Erdös, László id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 - first_name: Hong Chang full_name: Ji, Hong Chang id: dd216c0a-c1f9-11eb-beaf-e9ea9d2de76d last_name: Ji citation: ama: Erdös L, Ji HC. Wegner estimate and upper bound on the eigenvalue condition number of non-Hermitian random matrices. Communications on Pure and Applied Mathematics. 2024;77(9):3785-3840. doi:10.1002/cpa.22201 apa: Erdös, L., & Ji, H. C. (2024). Wegner estimate and upper bound on the eigenvalue condition number of non-Hermitian random matrices. Communications on Pure and Applied Mathematics. Wiley. https://doi.org/10.1002/cpa.22201 chicago: Erdös, László, and Hong Chang Ji. “Wegner Estimate and Upper Bound on the Eigenvalue Condition Number of Non-Hermitian Random Matrices.” Communications on Pure and Applied Mathematics. Wiley, 2024. https://doi.org/10.1002/cpa.22201. ieee: L. Erdös and H. C. Ji, “Wegner estimate and upper bound on the eigenvalue condition number of non-Hermitian random matrices,” Communications on Pure and Applied Mathematics, vol. 77, no. 9. Wiley, pp. 3785–3840, 2024. ista: Erdös L, Ji HC. 2024. Wegner estimate and upper bound on the eigenvalue condition number of non-Hermitian random matrices. Communications on Pure and Applied Mathematics. 77(9), 3785–3840. mla: Erdös, László, and Hong Chang Ji. “Wegner Estimate and Upper Bound on the Eigenvalue Condition Number of Non-Hermitian Random Matrices.” Communications on Pure and Applied Mathematics, vol. 77, no. 9, Wiley, 2024, pp. 3785–840, doi:10.1002/cpa.22201. short: L. Erdös, H.C. Ji, Communications on Pure and Applied Mathematics 77 (2024) 3785–3840. corr_author: '1' das_tickbox: '0' date_created: 2024-05-12T22:01:02Z date_published: 2024-09-01T00:00:00Z date_updated: 2026-10-16T08:35:46Z day: '01' ddc: - '510' department: - _id: LaEr doi: 10.1002/cpa.22201 ec_funded: 1 external_id: arxiv: - '2301.04981' isi: - '001217139900001' file: - access_level: open_access checksum: fbcc9cc7bf274f024e4f4afc9c208f96 content_type: application/pdf creator: dernst date_created: 2025-01-09T09:36:41Z date_updated: 2025-01-09T09:36:41Z file_id: '18803' file_name: 2024_CommPureApplMath_Erdoes.pdf file_size: 566963 relation: main_file success: 1 file_date_updated: 2025-01-09T09:36:41Z fulldoi: https://doi.org/10.1002/cpa.22201 has_accepted_license: '1' intvolume: ' 77' isi: 1 issue: '9' language: - iso: eng month: '09' oa: 1 oa_version: Published Version page: 3785-3840 project: - _id: 62796744-2b32-11ec-9570-940b20777f1d call_identifier: H2020 grant_number: '101020331' name: Random matrices beyond Wigner-Dyson-Mehta publication: Communications on Pure and Applied Mathematics publication_identifier: eissn: - 1097-0312 issn: - 0010-3640 publication_status: published publisher: Wiley quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: yes title: Wegner estimate and upper bound on the eigenvalue condition number of non-Hermitian random matrices tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 77 year: '2024' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '18762' abstract: - lang: eng text: Consider the random variable $\mathrm{Tr}( f_1(W)A_1\dots f_k(W)A_k)$ where $W$ is an $N\times N$ Hermitian Wigner matrix, $k\in\mathbb{N}$, and choose (possibly $N$-dependent) regular functions $f_1,\dots, f_k$ as well as bounded deterministic matrices $A_1,\dots,A_k$. We give a functional central limit theorem showing that the fluctuations around the expectation are Gaussian. Moreover, we determine the limiting covariance structure and give explicit error bounds in terms of the scaling of $f_1,\dots,f_k$ and the number of traceless matrices among $A_1,\dots,A_k$, thus extending the results of [Cipolloni, Erdős, Schröder 2023] to products of arbitrary length $k\geq2$. As an application, we consider the fluctuation of $\mathrm{Tr}(\mathrm{e}^{\mathrm{i} tW}A_1\mathrm{e}^{-\mathrm{i} tW}A_2)$ around its thermal value $\mathrm{Tr}(A_1)\mathrm{Tr}(A_2)$ when $t$ is large and give an explicit formula for the variance. acknowledgement: "I am very grateful to László Erdős for suggesting the topic and many valuable discussions during my work on the project. I would also like to thank the two anonymous referees for their careful reading of the manuscript and detailed feedback.\r\nPartially supported by ERC Advanced Grants “RMTBeyond” No. 101020331 and “LDRaM” No. 884584." article_number: '191' article_processing_charge: Yes article_type: original arxiv: 1 author: - first_name: Jana full_name: Reker, Jana id: e796e4f9-dc8d-11ea-abe3-97e26a0323e9 last_name: Reker citation: ama: Reker J. Multi-point functional central limit theorem for Wigner matrices. Electronic Journal of Probability. 2024;29. doi:10.1214/24-EJP1247 apa: Reker, J. (2024). Multi-point functional central limit theorem for Wigner matrices. Electronic Journal of Probability. Institute of Mathematical Statistics. https://doi.org/10.1214/24-EJP1247 chicago: Reker, Jana. “Multi-Point Functional Central Limit Theorem for Wigner Matrices.” Electronic Journal of Probability. Institute of Mathematical Statistics, 2024. https://doi.org/10.1214/24-EJP1247. ieee: J. Reker, “Multi-point functional central limit theorem for Wigner matrices,” Electronic Journal of Probability, vol. 29. Institute of Mathematical Statistics, 2024. ista: Reker J. 2024. Multi-point functional central limit theorem for Wigner matrices. Electronic Journal of Probability. 29, 191. mla: Reker, Jana. “Multi-Point Functional Central Limit Theorem for Wigner Matrices.” Electronic Journal of Probability, vol. 29, 191, Institute of Mathematical Statistics, 2024, doi:10.1214/24-EJP1247. short: J. Reker, Electronic Journal of Probability 29 (2024). corr_author: '1' das_tickbox: '0' date_created: 2025-01-05T23:01:58Z date_published: 2024-12-20T00:00:00Z date_updated: 2026-10-16T08:38:43Z day: '20' ddc: - '510' department: - _id: LaEr doi: 10.1214/24-EJP1247 ec_funded: 1 external_id: arxiv: - '2307.11028' isi: - '001381599200001' file: - access_level: open_access checksum: 67178feaa8630a332599d3037a3fe70e content_type: application/pdf creator: dernst date_created: 2025-01-08T08:44:03Z date_updated: 2025-01-08T08:44:03Z file_id: '18773' file_name: 2024_ElectrJournProbability_Reker.pdf file_size: 812428 relation: main_file success: 1 file_date_updated: 2025-01-08T08:44:03Z fulldoi: https://doi.org/10.1214/24-EJP1247 has_accepted_license: '1' intvolume: ' 29' isi: 1 language: - iso: eng month: '12' oa: 1 oa_version: Published Version project: - _id: 62796744-2b32-11ec-9570-940b20777f1d call_identifier: H2020 grant_number: '101020331' name: Random matrices beyond Wigner-Dyson-Mehta publication: Electronic Journal of Probability publication_identifier: eissn: - 1083-6489 publication_status: published publisher: Institute of Mathematical Statistics quality_controlled: '1' related_material: record: - id: '17173' relation: earlier_version status: public researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: no title: Multi-point functional central limit theorem for Wigner matrices tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 29 year: '2024' ... --- _id: '17154' abstract: - lang: eng text: We compute the deterministic approximation for mixed fluctuation moments of products of deterministic matrices and general Sobolev functions of Wigner matrices. Restricting to polynomials, our formulas reproduce recent results of Male et al. (Random Matrices Theory Appl. 11(2):2250015, 2022), showing that the underlying combinatorics of non-crossing partitions and annular non-crossing permutations continue to stay valid beyond the setting of second-order free probability theory. The formulas obtained further characterize the variance in the functional central limit theorem given in the recent companion paper (Reker in Preprint, arXiv:2204.03419, 2023). and thus allow identifying the fluctuation around the thermal value in certain thermalization problems. article_number: '10' article_processing_charge: Yes (via OA deal) article_type: original arxiv: 1 author: - first_name: Jana full_name: Reker, Jana id: e796e4f9-dc8d-11ea-abe3-97e26a0323e9 last_name: Reker citation: ama: Reker J. Fluctuation moments for regular functions of Wigner Matrices. Mathematical Physics, Analysis and Geometry. 2024;27(3). doi:10.1007/s11040-024-09483-y apa: Reker, J. (2024). Fluctuation moments for regular functions of Wigner Matrices. Mathematical Physics, Analysis and Geometry. Springer Nature. https://doi.org/10.1007/s11040-024-09483-y chicago: Reker, Jana. “Fluctuation Moments for Regular Functions of Wigner Matrices.” Mathematical Physics, Analysis and Geometry. Springer Nature, 2024. https://doi.org/10.1007/s11040-024-09483-y. ieee: J. Reker, “Fluctuation moments for regular functions of Wigner Matrices,” Mathematical Physics, Analysis and Geometry, vol. 27, no. 3. Springer Nature, 2024. ista: Reker J. 2024. Fluctuation moments for regular functions of Wigner Matrices. Mathematical Physics, Analysis and Geometry. 27(3), 10. mla: Reker, Jana. “Fluctuation Moments for Regular Functions of Wigner Matrices.” Mathematical Physics, Analysis and Geometry, vol. 27, no. 3, 10, Springer Nature, 2024, doi:10.1007/s11040-024-09483-y. short: J. Reker, Mathematical Physics, Analysis and Geometry 27 (2024). das_tickbox: '1' dataavailabilitystatement: Data sharing not applicable to this article as no datasets were generated or analysed during the current study. date_created: 2024-06-21T09:31:17Z date_published: 2024-06-20T00:00:00Z date_updated: 2026-10-16T08:35:04Z day: '20' ddc: - '519' department: - _id: LaEr doi: 10.1007/s11040-024-09483-y ec_funded: 1 external_id: arxiv: - '2307.11029' isi: - '001251464300001' file: - access_level: open_access checksum: 7d04318d66f765621bdcb648378d458e content_type: application/pdf creator: cchlebak date_created: 2024-06-26T11:26:42Z date_updated: 2024-06-26T11:26:42Z file_id: '17175' file_name: 2024_MathPhysAnaGeo_Reker.pdf file_size: 1327596 relation: main_file success: 1 file_date_updated: 2024-06-26T11:26:42Z fulldoi: https://doi.org/10.1007/s11040-024-09483-y has_accepted_license: '1' intvolume: ' 27' isi: 1 issue: '3' language: - iso: eng month: '06' oa: 1 oa_version: Published Version project: - _id: B67AFEDC-15C9-11EA-A837-991A96BB2854 name: IST Austria Open Access Fund - _id: 62796744-2b32-11ec-9570-940b20777f1d call_identifier: H2020 grant_number: '101020331' name: Random matrices beyond Wigner-Dyson-Mehta publication: Mathematical Physics, Analysis and Geometry publication_identifier: eissn: - 1572-9656 issn: - 1385-0172 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: record: - id: '17164' relation: dissertation_contains status: public researchdata_availability: not applicable scopus_import: '1' status: public supplementarymaterial: yes title: Fluctuation moments for regular functions of Wigner Matrices tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 27 year: '2024' ... --- OA_place: repository OA_type: green _id: '18656' abstract: - lang: eng text: "We consider the time evolution of the out-of-time-ordered correlator (OTOC) of two general observables \r\n and \r\n in a mean field chaotic quantum system described by a random Wigner matrix as its Hamiltonian. We rigorously identify three time regimes separated by the physically relevant scrambling and relaxation times. The main feature of our analysis is that we express the error terms in the optimal Schatten (tracial) norms of the observables, allowing us to track the exact dependence of the errors on their rank. In particular, for significantly overlapping observables with low rank the OTOC is shown to exhibit a significant local maximum at the scrambling time, a feature that may not have been noticed in the physics literature before. Our main tool is a novel multi-resolvent local law with Schatten norms that unifies and improves previous local laws involving either the much cruder operator norm (cf. [10]) or the Hilbert-Schmidt norm (cf. [11])." acknowledgement: LE and JH were supported by the ERC Advanced Grant łRMTBeyondž No. 101020331 article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Giorgio full_name: Cipolloni, Giorgio id: 42198EFA-F248-11E8-B48F-1D18A9856A87 last_name: Cipolloni orcid: 0000-0002-4901-7992 - first_name: László full_name: Erdös, László id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 - first_name: Sven Joscha full_name: Henheik, Sven Joscha id: 31d731d7-d235-11ea-ad11-b50331c8d7fb last_name: Henheik orcid: 0000-0003-1106-327X citation: ama: Cipolloni G, Erdös L, Henheik SJ. Out-of-time-ordered correlators for Wigner matrices. Advances in Theoretical and Mathematical Physics. 2024;28(6):2025-2083. doi:10.4310/ATMP.241031013250 apa: Cipolloni, G., Erdös, L., & Henheik, S. J. (2024). Out-of-time-ordered correlators for Wigner matrices. Advances in Theoretical and Mathematical Physics. International Press of Boston. https://doi.org/10.4310/ATMP.241031013250 chicago: Cipolloni, Giorgio, László Erdös, and Sven Joscha Henheik. “Out-of-Time-Ordered Correlators for Wigner Matrices.” Advances in Theoretical and Mathematical Physics. International Press of Boston, 2024. https://doi.org/10.4310/ATMP.241031013250. ieee: G. Cipolloni, L. Erdös, and S. J. Henheik, “Out-of-time-ordered correlators for Wigner matrices,” Advances in Theoretical and Mathematical Physics, vol. 28, no. 6. International Press of Boston, pp. 2025–2083, 2024. ista: Cipolloni G, Erdös L, Henheik SJ. 2024. Out-of-time-ordered correlators for Wigner matrices. Advances in Theoretical and Mathematical Physics. 28(6), 2025–2083. mla: Cipolloni, Giorgio, et al. “Out-of-Time-Ordered Correlators for Wigner Matrices.” Advances in Theoretical and Mathematical Physics, vol. 28, no. 6, International Press of Boston, 2024, pp. 2025–83, doi:10.4310/ATMP.241031013250. short: G. Cipolloni, L. Erdös, S.J. Henheik, Advances in Theoretical and Mathematical Physics 28 (2024) 2025–2083. corr_author: '1' das_tickbox: '1' date_created: 2024-12-15T23:01:51Z date_published: 2024-10-30T00:00:00Z date_updated: 2026-10-16T08:35:25Z day: '30' department: - _id: LaEr doi: 10.4310/ATMP.241031013250 ec_funded: 1 external_id: arxiv: - '2402.17609' fulldoi: https://doi.org/10.4310/ATMP.241031013250 intvolume: ' 28' issue: '6' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2402.17609 month: '10' oa: 1 oa_version: Preprint page: 2025-2083 project: - _id: 62796744-2b32-11ec-9570-940b20777f1d call_identifier: H2020 grant_number: '101020331' name: Random matrices beyond Wigner-Dyson-Mehta publication: Advances in Theoretical and Mathematical Physics publication_identifier: eissn: - 1095-0753 issn: - 1095-0761 publication_status: published publisher: International Press of Boston quality_controlled: '1' related_material: record: - id: '19540' relation: dissertation_contains status: public researchdata_availability: unclear scopus_import: '1' status: public supplementarymaterial: unclear title: Out-of-time-ordered correlators for Wigner matrices type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 28 year: '2024' ... --- OA_place: publisher _id: '17319' abstract: - lang: eng text: "This thesis comprises two distinct projects, each offering unique insights into fundamental\r\ncellular processes. While distinct in their focus, these different perspectives have a common\r\ntheme: chemiosmotic theory and utilisation of the proton gradient for driving the essential\r\nprocesses like auxin efflux and ATP synthesis, effectively bridging the membrane protein\r\nstructure and function from the realms of plant biology and cellular bioenergetics.\r\nThe first project of this thesis centres on the characterisation of PIN proteins, a class of\r\ntransmembrane transporters pivotal in the regulation of auxin transport and distribution in\r\nplants. PINs form a conserved and phylogenetically abundant group of transporters present in\r\nland plants and certain algae. Despite their great importance, they were one of the few elusive\r\nproteins essential for plant development not to be structurally and mechanistically\r\ncharacterised since their discovery almost 30 years ago. This work aimed to uncover the\r\nstructural and functional dynamics of the PIN protein-mediated auxin transport using an array\r\nof experimental techniques, including protein purification, biochemical assays and structural\r\nanalysis. Through an exhaustive screening process that took several years and included testing\r\ndifferent PIN homologues, expression systems, constructs, and purification conditions, we\r\ndeveloped a robust protocol for isolating the pure, stable, and monodisperse PIN8 protein.\r\nMoreover, utilising biophysical methods and buffer screening, we demonstrated that PIN8\r\nexhibits detergent and pH-dependent stability, with mild detergents and lower pH (5.0 and 6.0)\r\nbeing optimal for the stability of the protein. Using SEC-MALS and crosslinking, we\r\ndetermined that PIN8 forms dimers, which was confirmed by our structural studies. We\r\nobtained a cryo-EM map of PIN8 at pH 6.0, and, compared to recently published structures,\r\nour map implies major pH-dependent conformational changes and possibly utilisation of the\r\nproton gradient in the transport mechanism.\r\nThe subject of the second project was F1Fo-ATP synthase, an enzyme complex fundamental\r\nto cellular energy metabolism. Through an approach integrating biochemical assays and\r\nstructural analysis, this research aimed to unveil the molecular mechanism of inhibition of ATP\r\nsynthase by yaku´amide, a bioactive compound with potential therapeutic implications. Using\r\nsubmitochondrial particles and purified F1Fo-ATP synthase, we demonstrated that, contrary to\r\npublished data, yaku´amide inhibits both ATP hydrolysis and ATP synthesis reactions.\r\nMoreover, we found that yaku´amide inhibitory activity is proton motive force (pmf)\r\ndependent, with lower inhibition in a more coupled system. Utilising cryo-EM, we obtained\r\nmaps and models for the three main rotational states of murine ATP synthase (State 1 at 3.0 Å,\r\n8\r\nState 2 at 3.1 Å, and State 3 at 3.2 Å, overall). We observed several new features in our maps;\r\nhowever, we cannot definitively determine the exact mechanism of yaku amide’s inhibition on\r\nthe protein due to either resolution limits or suboptimal binding of the inhibitor." acknowledged_ssus: - _id: EM-Fac - _id: LifeSc alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Kristina full_name: Lukic, Kristina id: 2B04DB84-F248-11E8-B48F-1D18A9856A87 last_name: Lukic orcid: 0000-0003-1581-881X citation: ama: 'Lukic K. Membrane proteins in plant physiology and bioenergetics : Investigating auxin efflux transporter PIN8 and ATP synthase inhibition by the novel inhibitor Yaku’amide B. 2024. doi:10.15479/at:ista:17319' apa: 'Lukic, K. (2024). Membrane proteins in plant physiology and bioenergetics : Investigating auxin efflux transporter PIN8 and ATP synthase inhibition by the novel inhibitor Yaku’amide B. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:17319' chicago: 'Lukic, Kristina. “Membrane Proteins in Plant Physiology and Bioenergetics : Investigating Auxin Efflux Transporter PIN8 and ATP Synthase Inhibition by the Novel Inhibitor Yaku’amide B.” Institute of Science and Technology Austria, 2024. https://doi.org/10.15479/at:ista:17319.' ieee: 'K. Lukic, “Membrane proteins in plant physiology and bioenergetics : Investigating auxin efflux transporter PIN8 and ATP synthase inhibition by the novel inhibitor Yaku’amide B,” Institute of Science and Technology Austria, 2024.' ista: 'Lukic K. 2024. Membrane proteins in plant physiology and bioenergetics : Investigating auxin efflux transporter PIN8 and ATP synthase inhibition by the novel inhibitor Yaku’amide B. Institute of Science and Technology Austria.' mla: 'Lukic, Kristina. Membrane Proteins in Plant Physiology and Bioenergetics : Investigating Auxin Efflux Transporter PIN8 and ATP Synthase Inhibition by the Novel Inhibitor Yaku’amide B. Institute of Science and Technology Austria, 2024, doi:10.15479/at:ista:17319.' short: 'K. Lukic, Membrane Proteins in Plant Physiology and Bioenergetics : Investigating Auxin Efflux Transporter PIN8 and ATP Synthase Inhibition by the Novel Inhibitor Yaku’amide B, Institute of Science and Technology Austria, 2024.' corr_author: '1' das_tickbox: '0' date_created: 2024-07-26T09:05:55Z date_published: 2024-07-26T00:00:00Z date_updated: 2026-10-16T08:50:36Z day: '26' ddc: - '580' degree_awarded: PhD department: - _id: LeSa - _id: GradSch doi: 10.15479/at:ista:17319 doi_confirm: '1' file: - access_level: open_access checksum: 95517e697ea6a87e267e649cad560989 content_type: application/pdf creator: cchlebak date_created: 2024-07-26T13:14:24Z date_updated: 2025-01-26T23:30:04Z embargo: 2025-01-26 file_id: '17320' file_name: Thesis_Kristina_Lukic.pdf file_size: 24639084 relation: main_file - access_level: closed checksum: 74325746a9a05078fb9935dbf2aef752 content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: cchlebak date_created: 2024-07-26T13:14:50Z date_updated: 2025-01-26T23:30:04Z embargo_to: open_access file_id: '17321' file_name: Thesis_Kristina_Lukic.docx file_size: 96334272 relation: source_file file_date_updated: 2025-01-26T23:30:04Z fulldoi: https://doi.org/10.15479/at:ista:17319 has_accepted_license: '1' language: - iso: eng month: '07' oa: 1 oa_version: Published Version page: '224' publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria researchdata_availability: no status: public supervisor: - first_name: Leonid A full_name: Sazanov, Leonid A id: 338D39FE-F248-11E8-B48F-1D18A9856A87 last_name: Sazanov orcid: 0000-0002-0977-7989 supplementarymaterial: no title: 'Membrane proteins in plant physiology and bioenergetics : Investigating auxin efflux transporter PIN8 and ATP synthase inhibition by the novel inhibitor Yaku''amide B' type: dissertation user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 year: '2024' ... --- DOAJ_listed: '1' _id: '17326' abstract: - lang: eng text: Magnetic fields in the stellar interiors are key candidates to explain observed core rotation rates inside solar-like stars along their evolution. Recently, asteroseismic estimates of radial magnetic field amplitudes near the hydrogen-burning shell (H-shell) inside about 24 red giants (RGs) have been obtained by measuring frequency splittings from their power spectra. Using general Lorentz-stress (magnetic) kernels, we investigated the potential for detectability of near-surface magnetism in a 1.3 M⊙ star of supersolar metallicity as it evolves from a mid subgiant to a late subgiant into an RG. Based on these sensitivity kernels, we decompose an RG into three zones—deep core, H-shell, and near-surface. The subgiants instead required decomposition into an inner core, an outer core, and a near-surface layer. Additionally, we find that for a low-frequency g-dominated dipolar mode in the presence of a typical stable magnetic field, ∼25% of the frequency shift comes from the H-shell and the remaining from deeper layers. The ratio of the subsurface tangential field to the radial field in the H-burning shell decides if subsurface fields may be potentially detectable. For p-dominated dipole modes close to vmax, this ratio is around two orders of magnitude smaller in subgiant phases than the corresponding RG. Further, with the availability of magnetic kernels, we propose lower limits of field strengths in crucial layers in our stellar model during its evolutionary phases. The theoretical prescription outlined here provides the first formal way to devise inverse problems for stellar magnetism and can be seamlessly employed for slow rotators. acknowledgement: "This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 101034413. S.\r\nB.D. acknowledges Prof. Jeroen Tromp at Princeton University for supporting a part of this work. S.M.H., S.B., and S.P. acknowledge support from the Department of Atomic Energy,\r\nGovernment of India, under Project Identification No. RTI 4002. The authors would like to thank the reviewer(s) and data editor for their constructive comments and suggestions. The\r\ngeneration of the stellar models was done using the Modules for Experiments in Stellar Astrophysics (MESA Paxton et al. 2011, 2013, 2015, 2018, 2019; we have used MESA version\r\nr22.05.1 for RG and r23.05.1 for SG models, MESA-SDK version x86_64-linux-22.6.1). The eigenfrequencies and eigenfunctions for this model were calculated using the GYRE\r\n(Townsend & Teitler 2013) code. The code to calculate the kernels and the splittings has been written completely in Python 3.8.16." article_number: '42' article_processing_charge: Yes article_type: original arxiv: 1 author: - first_name: Shatanik full_name: Bhattacharya, Shatanik last_name: Bhattacharya - first_name: Srijan B full_name: Das, Srijan B id: 9ce7c423-dacf-11ed-8942-e09c6cb27149 last_name: Das orcid: 0000-0003-0896-7972 - first_name: Lisa Annabelle full_name: Bugnet, Lisa Annabelle id: d9edb345-f866-11ec-9b37-d119b5234501 last_name: Bugnet orcid: 0000-0003-0142-4000 - first_name: Subrata full_name: Panda, Subrata last_name: Panda - first_name: Shravan M. full_name: Hanasoge, Shravan M. last_name: Hanasoge citation: ama: Bhattacharya S, Das SB, Bugnet LA, Panda S, Hanasoge SM. Detectability of axisymmetric magnetic fields from the core to the surface of oscillating post-main-sequence stars. Astrophysical Journal. 2024;970(1). doi:10.3847/1538-4357/ad4708 apa: Bhattacharya, S., Das, S. B., Bugnet, L. A., Panda, S., & Hanasoge, S. M. (2024). Detectability of axisymmetric magnetic fields from the core to the surface of oscillating post-main-sequence stars. Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ad4708 chicago: Bhattacharya, Shatanik, Srijan B Das, Lisa Annabelle Bugnet, Subrata Panda, and Shravan M. Hanasoge. “Detectability of Axisymmetric Magnetic Fields from the Core to the Surface of Oscillating Post-Main-Sequence Stars.” Astrophysical Journal. IOP Publishing, 2024. https://doi.org/10.3847/1538-4357/ad4708. ieee: S. Bhattacharya, S. B. Das, L. A. Bugnet, S. Panda, and S. M. Hanasoge, “Detectability of axisymmetric magnetic fields from the core to the surface of oscillating post-main-sequence stars,” Astrophysical Journal, vol. 970, no. 1. IOP Publishing, 2024. ista: Bhattacharya S, Das SB, Bugnet LA, Panda S, Hanasoge SM. 2024. Detectability of axisymmetric magnetic fields from the core to the surface of oscillating post-main-sequence stars. Astrophysical Journal. 970(1), 42. mla: Bhattacharya, Shatanik, et al. “Detectability of Axisymmetric Magnetic Fields from the Core to the Surface of Oscillating Post-Main-Sequence Stars.” Astrophysical Journal, vol. 970, no. 1, 42, IOP Publishing, 2024, doi:10.3847/1538-4357/ad4708. short: S. Bhattacharya, S.B. Das, L.A. Bugnet, S. Panda, S.M. Hanasoge, Astrophysical Journal 970 (2024). das_tickbox: '0' date_created: 2024-07-28T22:01:09Z date_published: 2024-07-15T00:00:00Z date_updated: 2026-10-16T08:51:03Z day: '15' ddc: - '520' department: - _id: LiBu doi: 10.3847/1538-4357/ad4708 ec_funded: 1 external_id: arxiv: - '2404.17167' isi: - '001270972500001' file: - access_level: open_access checksum: acb42a87deecbc9228fbbe6a48a37ec6 content_type: application/pdf creator: dernst date_created: 2024-07-29T11:02:48Z date_updated: 2024-07-29T11:02:48Z file_id: '17340' file_name: 2024_AstrophysicalJourn_Bhattacharya.pdf file_size: 3912290 relation: main_file success: 1 file_date_updated: 2024-07-29T11:02:48Z fulldoi: https://doi.org/10.3847/1538-4357/ad4708 has_accepted_license: '1' intvolume: ' 970' isi: 1 issue: '1' language: - iso: eng month: '07' oa: 1 oa_version: Published Version project: - _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c call_identifier: H2020 grant_number: '101034413' name: 'IST-BRIDGE: International postdoctoral program' publication: Astrophysical Journal publication_identifier: eissn: - 1538-4357 issn: - 0004-637X publication_status: published publisher: IOP Publishing quality_controlled: '1' researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: yes title: Detectability of axisymmetric magnetic fields from the core to the surface of oscillating post-main-sequence stars tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 970 year: '2024' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '18172' abstract: - lang: eng text: Red Giant stars host solar-like oscillations which have mixed character, being sensitive to conditions both in the outer convection zone and deep within the interior. The properties of these modes are sensitive to both core rotation and magnetic fields. While asteroseismic studies of the former have been done on a large scale, studies of the latter are currently limited to tens of stars. We aim to produce the first large catalogue of both magnetic and rotational perturbations. We jointly constrain these parameters by devising an automated method for fitting the power spectra directly. We successfully apply the method to 302 low-luminosity red giants. We find a clear bimodality in core rotation rate. The primary peak is at δνrot = 0.32 μHz, and the secondary at δνrot = 0.47 μHz. Combining our results with literature values, we find that the percentage of stars rotating much more rapidly than the population average increases with evolutionary state. We measure magnetic splittings of 2σ significance in 23 stars. While the most extreme magnetic splitting values appear in stars with masses > 1.1M⊙, implying they formerly hosted a convective core, a small but statistically significant magnetic splitting is measured at lower masses. Asymmetry between the frequencies of a rotationally split multiplet has previously been used to diagnose the presence of a magnetic perturbation. We find that of the stars with a significant detection of magnetic perturbation, 43\% do not show strong asymmetry. We find no strong evidence of correlation between the rotation and magnetic parameters. acknowledgement: EJH, WJC, and GRD acknowledge the support of Science and Technology Facilities Council. MBN acknowledges support from the UK Space Agency. JMJO acknowledges support from NASA through the NASA Hubble Fellowship grant HST-HF2-51517.001, awarded by STScI (Space Telescope Science Institute), which is operated by the Association of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-26555. The authors acknowledge use of the Blue-BEAR HPC service at the University of Birmingham. This paper includes data collected by the Kepler mission and obtained from the MAST data archive at the Space Telescope Science Institute (STScI). Funding for the Kepler mission was provided by the NASA Science Mission Directorate. This work has made use of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/web/gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos.esa.int/web/gaia/dpac/consortium). Funding for the DPAC was provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. This paper received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (CartographY GA. 804752). SD and JB acknowledge support from the Centre National d’Etudes Spatiales (CNES). article_processing_charge: Yes article_type: original arxiv: 1 author: - first_name: Emily J. full_name: Hatt, Emily J. last_name: Hatt - first_name: J. M.Joel full_name: Ong, J. M.Joel last_name: Ong - first_name: Martin B. full_name: Nielsen, Martin B. last_name: Nielsen - first_name: William J. full_name: Chaplin, William J. last_name: Chaplin - first_name: Guy R. full_name: Davies, Guy R. last_name: Davies - first_name: Sébastien full_name: Deheuvels, Sébastien last_name: Deheuvels - first_name: Jérôme full_name: Ballot, Jérôme last_name: Ballot - first_name: Gang full_name: Li, Gang last_name: Li - first_name: Lisa Annabelle full_name: Bugnet, Lisa Annabelle id: d9edb345-f866-11ec-9b37-d119b5234501 last_name: Bugnet orcid: 0000-0003-0142-4000 citation: ama: Hatt EJ, Ong JMJ, Nielsen MB, et al. Asteroseismic signatures of core magnetism and rotation in hundreds of low-luminosity red giants. Monthly Notices of the Royal Astronomical Society. 2024;534(2):1060-1076. doi:10.1093/mnras/stae2053 apa: Hatt, E. J., Ong, J. M. J., Nielsen, M. B., Chaplin, W. J., Davies, G. R., Deheuvels, S., … Bugnet, L. A. (2024). Asteroseismic signatures of core magnetism and rotation in hundreds of low-luminosity red giants. Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/stae2053 chicago: Hatt, Emily J., J. M.Joel Ong, Martin B. Nielsen, William J. Chaplin, Guy R. Davies, Sébastien Deheuvels, Jérôme Ballot, Gang Li, and Lisa Annabelle Bugnet. “Asteroseismic Signatures of Core Magnetism and Rotation in Hundreds of Low-Luminosity Red Giants.” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2024. https://doi.org/10.1093/mnras/stae2053. ieee: E. J. Hatt et al., “Asteroseismic signatures of core magnetism and rotation in hundreds of low-luminosity red giants,” Monthly Notices of the Royal Astronomical Society, vol. 534, no. 2. Oxford University Press, pp. 1060–1076, 2024. ista: Hatt EJ, Ong JMJ, Nielsen MB, Chaplin WJ, Davies GR, Deheuvels S, Ballot J, Li G, Bugnet LA. 2024. Asteroseismic signatures of core magnetism and rotation in hundreds of low-luminosity red giants. Monthly Notices of the Royal Astronomical Society. 534(2), 1060–1076. mla: Hatt, Emily J., et al. “Asteroseismic Signatures of Core Magnetism and Rotation in Hundreds of Low-Luminosity Red Giants.” Monthly Notices of the Royal Astronomical Society, vol. 534, no. 2, Oxford University Press, 2024, pp. 1060–76, doi:10.1093/mnras/stae2053. short: E.J. Hatt, J.M.J. Ong, M.B. Nielsen, W.J. Chaplin, G.R. Davies, S. Deheuvels, J. Ballot, G. Li, L.A. Bugnet, Monthly Notices of the Royal Astronomical Society 534 (2024) 1060–1076. das_tickbox: '1' dataavailabilitystatement: Table 1 is available at the CDS. Light curves used in this work are available at Mikulski Archive for Space Telescopes at the Space Telescope Science Institute (MAST)1. Other intermediate data products will be made available upon reasonable request. date_created: 2024-10-06T22:01:11Z date_published: 2024-10-01T00:00:00Z date_updated: 2026-10-16T08:52:08Z day: '01' ddc: - '520' department: - _id: LiBu doi: 10.1093/mnras/stae2053 external_id: arxiv: - '2409.01157' isi: - '001320536900011' file: - access_level: open_access checksum: b79f3c6a5991516abbcc8d34fa4bfb5f content_type: application/pdf creator: dernst date_created: 2024-10-07T09:14:03Z date_updated: 2024-10-07T09:14:03Z file_id: '18182' file_name: 2024_MonthlyNRoyalAstronSoc_Hatt.pdf file_size: 2813008 relation: main_file success: 1 file_date_updated: 2024-10-07T09:14:03Z fulldoi: https://doi.org/10.1093/mnras/stae2053 has_accepted_license: '1' intvolume: ' 534' isi: 1 issue: '2' language: - iso: eng month: '10' oa: 1 oa_version: Published Version page: 1060-1076 publication: Monthly Notices of the Royal Astronomical Society publication_identifier: eissn: - 1365-2966 issn: - 0035-8711 publication_status: published publisher: Oxford University Press quality_controlled: '1' researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: yes title: Asteroseismic signatures of core magnetism and rotation in hundreds of low-luminosity red giants tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 534 year: '2024' ... --- _id: '15323' abstract: - lang: eng text: Supercomplexes of the respiratory chain are established constituents of the oxidative phosphorylation system, but their role in mammalian metabolism has been hotly debated. Although recent studies have shown that different tissues/organs are equipped with specific sets of supercomplexes, depending on their metabolic needs, the notion that supercomplexes have a role in the regulation of metabolism has been challenged. However, irrespective of the mechanistic conclusions, the composition of various high molecular weight supercomplexes remains uncertain. Here, using cryogenic electron microscopy, we demonstrate that mammalian (mouse) tissues contain three defined types of ‘respirasome’, supercomplexes made of CI, CIII2 and CIV. The stoichiometry and position of CIV differs in the three respirasomes, of which only one contains the supercomplex-associated factor SCAF1, whose involvement in respirasome formation has long been contended. Our structures confirm that the ‘canonical’ respirasome (the C-respirasome, CICIII2CIV) does not contain SCAF1, which is instead associated to a different respirasome (the CS-respirasome), containing a second copy of CIV. We also identify an alternative respirasome (A-respirasome), with CIV bound to the ‘back’ of CI, instead of the ‘toe’. This structural characterization of mouse mitochondrial supercomplexes allows us to hypothesize a mechanistic basis for their specific role in different metabolic conditions. acknowledged_ssus: - _id: EM-Fac - _id: LifeSc - _id: PreCl - _id: ScienComp acknowledgement: Supercomplexes of the respiratory chain are established constituents of the oxidative phosphorylation system, but their role in mammalian metabolism has been hotly debated. Although recent studies have shown that different tissues/organs are equipped with specific sets of supercomplexes, depending on their metabolic needs, the notion that supercomplexes have a role in the regulation of metabolism has been challenged. However, irrespective of the mechanistic conclusions, the composition of various high molecular weight supercomplexes remains uncertain. Here, using cryogenic electron microscopy, we demonstrate that mammalian (mouse) tissues contain three defined types of ‘respirasome’, supercomplexes made of CI, CIII2 and CIV. The stoichiometry and position of CIV differs in the three respirasomes, of which only one contains the supercomplex-associated factor SCAF1, whose involvement in respirasome formation has long been contended. Our structures confirm that the ‘canonical’ respirasome (the C-respirasome, CICIII2CIV) does not contain SCAF1, which is instead associated to a different respirasome (the CS-respirasome), containing a second copy of CIV. We also identify an alternative respirasome (A-respirasome), with CIV bound to the ‘back’ of CI, instead of the ‘toe’. This structural characterization of mouse mitochondrial supercomplexes allows us to hypothesize a mechanistic basis for their specific role in different metabolic conditions. article_processing_charge: No article_type: original author: - first_name: Irene full_name: Vercellino, Irene id: 3ED6AF16-F248-11E8-B48F-1D18A9856A87 last_name: Vercellino orcid: 0000-0001-5618-3449 - first_name: Leonid A full_name: Sazanov, Leonid A id: 338D39FE-F248-11E8-B48F-1D18A9856A87 last_name: Sazanov orcid: 0000-0002-0977-7989 citation: ama: Vercellino I, Sazanov LA. SCAF1 drives the compositional diversity of mammalian respirasomes. Nature Structural and Molecular Biology. 2024;31:1061-1071. doi:10.1038/s41594-024-01255-0 apa: Vercellino, I., & Sazanov, L. A. (2024). SCAF1 drives the compositional diversity of mammalian respirasomes. Nature Structural and Molecular Biology. Springer Nature. https://doi.org/10.1038/s41594-024-01255-0 chicago: Vercellino, Irene, and Leonid A Sazanov. “SCAF1 Drives the Compositional Diversity of Mammalian Respirasomes.” Nature Structural and Molecular Biology. Springer Nature, 2024. https://doi.org/10.1038/s41594-024-01255-0. ieee: I. Vercellino and L. A. Sazanov, “SCAF1 drives the compositional diversity of mammalian respirasomes,” Nature Structural and Molecular Biology, vol. 31. Springer Nature, pp. 1061–1071, 2024. ista: Vercellino I, Sazanov LA. 2024. SCAF1 drives the compositional diversity of mammalian respirasomes. Nature Structural and Molecular Biology. 31, 1061–1071. mla: Vercellino, Irene, and Leonid A. Sazanov. “SCAF1 Drives the Compositional Diversity of Mammalian Respirasomes.” Nature Structural and Molecular Biology, vol. 31, Springer Nature, 2024, pp. 1061–71, doi:10.1038/s41594-024-01255-0. short: I. Vercellino, L.A. Sazanov, Nature Structural and Molecular Biology 31 (2024) 1061–1071. corr_author: '1' das_tickbox: '1' dataavailabilitystatement: 'Structures of the three SCs were deposited in PDB (accessions 8PW5, 8PW6 and 8PW7) with corresponding cryo-EM density maps in EMDB (IDs 17989, 17990 and 17991). As the models were built on composite maps, the consensus and focused maps for all components of the three SCs have also been deposited on EMDB (18023, 18022, 18025, 18024, 18027, 18026, 18017, 18018, 18019, 18021, 18020, 18015, 18011, 18012, 18013 and 18014). Similarly, structures of complex I were deposited in PDB (accessions 8RGR, 8RGQ, 8RGP and 8RGT) with corresponding composite cryo-EM density maps (19147, 19146, 19145 and 19148) and consensus/focused maps (19085, 19086, 19087, 19091, 19092, 19093, 19088, 19089, 19090, 19105, 19106 and 19107) in EMDB. The following previously deposited models (PDB codes) have been used in the manuscript: 5gup, 5xth, 5iy5, 1ooc, 5z62, 3cx5, 7o3c, 5j4z, 5j7y, 7o37 and 6g2j. Uncropped gels and western blot, as well as the raw data for the activity assays summarized in Extended Data Fig. 8h, have been provided as Source data in this publication. Source data are provided with this paper.' date_created: 2024-04-14T22:01:03Z date_published: 2024-07-01T00:00:00Z date_updated: 2026-10-16T08:43:37Z day: '01' ddc: - '572' department: - _id: LeSa doi: 10.1038/s41594-024-01255-0 ec_funded: 1 external_id: isi: - '001196897300001' pmid: - '38575788' file: - access_level: open_access checksum: 21f05d188762acd7f49a97f3d09c8d9f content_type: application/pdf creator: lsazanov date_created: 2024-05-14T11:57:56Z date_updated: 2025-01-01T23:30:03Z embargo: 2025-01-01 file_id: '15392' file_name: megacomplex_submit_NSMB_withFigures.pdf file_size: 24424729 relation: main_file file_date_updated: 2025-01-01T23:30:03Z fulldoi: https://doi.org/10.1038/s41594-024-01255-0 has_accepted_license: '1' intvolume: ' 31' isi: 1 language: - iso: eng month: '07' oa: 1 oa_version: Submitted Version page: 1061-1071 pmid: 1 project: - _id: 627abdeb-2b32-11ec-9570-ec31a97243d3 call_identifier: H2020 grant_number: '101020697' name: Structure and mechanism of respiratory chain molecular machines publication: Nature Structural and Molecular Biology publication_identifier: eissn: - 1545-9985 issn: - 1545-9993 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: link: - relation: erratum url: https://doi.org/10.1038/s41594-025-01721-3 researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: yes title: SCAF1 drives the compositional diversity of mammalian respirasomes tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 31 year: '2024' ... --- OA_place: publisher OA_type: hybrid _id: '18967' abstract: - lang: eng text: "Background: We identified small molecule tricyclic pyrone compound CP2 as a mild mitochondrial complex I (MCI) inhibitor that induces neuroprotection in multiple mouse models of AD. One of the major concerns while targeting mitochondria is the production of reactive oxygen species (ROS). CP2 consists of two diastereoisomers, D1 and D2, with distinct activity and toxicity profiles. This study was designed to understand how structure of D1 and D2 affects their binding to MCI and the consequential impact on ROS production.\r\n\r\nMethod: The X-ray crystallography and cryo-electron microscopy (cryo-EM) at global resolution of 3.25-3.27Å were employed to identify the molecular structure of D1 and D2 and the D1 binding to the isolated ovine MCI. The assessment of the MCI inhibition and the extent of ROS generation were done in isolated MCI and human neuroblastoma MC65 cells using flow cytometry, a Seahorse extracellular flux analyzer, and the kinetic studies.\r\n\r\nResult: In the closed conformation of MCI, D1 selectively binds to the deep Quinone-site (Qd) but not to the shallow Q-site (Qs), sharing the same binding pocket as rotenone. In the open MCI state, D1 exclusively binds to the Qs in contrast to rotenone, which binds Qd and Qs in both closed and open states. At the same concentrations, D1 inhibits respiration to a greater extent compared to D2 (5:1 ratio) and produces higher level of ROS.\r\n\r\nConclusion:Cryo-EM unambiguously identified binding of D1 to both the Qd and Qs sites, contingent upon the conformational state of MCI. In contrast to rotenone, D1 binds Qd only in the closed conformation during catalytic cycle, leading to mild inhibition. Superimposing X-ray crystallography data of D1 and D2 onto cryo-EM data suggests that the orientation of the methyl group in D2 induces a flatter conformation, resulting in lower binding affinity to MCI, which correlates with lower inhibition and toxicity compared to D1. At physiologically relevant concentrations, CP2 (D1:D2 = 1:1) demonstrates low MCI inhibition yielding negligible ROS levels. This observation provides new insight into the absence of toxicity associated with CP2 treatment in vivo, further highlighting feasibility for the development of safe and efficacious MCI inhibitors." article_number: e085971 article_processing_charge: Yes (in subscription journal) author: - first_name: Olga full_name: Petrova, Olga id: 5D8C9660-5D49-11EA-8188-567B3DDC885E last_name: Petrova - first_name: Sergey A full_name: Trushin, Sergey A last_name: Trushin - first_name: Thi Kim Oanh full_name: Nguyen, Thi Kim Oanh last_name: Nguyen - first_name: Mark full_name: Ostroot, Mark last_name: Ostroot - first_name: Matthew full_name: Schellenberg, Matthew last_name: Schellenberg - first_name: Graham full_name: Johnson, Graham last_name: Johnson - first_name: Eugenia full_name: Trushina, Eugenia last_name: Trushina - first_name: Leonid A full_name: Sazanov, Leonid A id: 338D39FE-F248-11E8-B48F-1D18A9856A87 last_name: Sazanov orcid: 0000-0002-0977-7989 citation: ama: Petrova O, Trushin SA, Nguyen TKO, et al. Structure‐activity Relationship Study of Neuroprotective Complex I Inhibitor CP2. Vol 20. Wiley; 2024. doi:10.1002/alz.085971 apa: Petrova, O., Trushin, S. A., Nguyen, T. K. O., Ostroot, M., Schellenberg, M., Johnson, G., … Sazanov, L. A. (2024). Structure‐activity relationship study of neuroprotective complex I inhibitor CP2. Alzheimer’s & Dementia (Vol. 20). Wiley. https://doi.org/10.1002/alz.085971 chicago: Petrova, Olga, Sergey A Trushin, Thi Kim Oanh Nguyen, Mark Ostroot, Matthew Schellenberg, Graham Johnson, Eugenia Trushina, and Leonid A Sazanov. Structure‐activity Relationship Study of Neuroprotective Complex I Inhibitor CP2. Alzheimer’s & Dementia. Vol. 20. Wiley, 2024. https://doi.org/10.1002/alz.085971. ieee: O. Petrova et al., Structure‐activity relationship study of neuroprotective complex I inhibitor CP2, vol. 20, no. S6. Wiley, 2024. ista: Petrova O, Trushin SA, Nguyen TKO, Ostroot M, Schellenberg M, Johnson G, Trushina E, Sazanov LA. 2024. Structure‐activity relationship study of neuroprotective complex I inhibitor CP2, Wiley,p. mla: Petrova, Olga, et al. “Structure‐activity Relationship Study of Neuroprotective Complex I Inhibitor CP2.” Alzheimer’s & Dementia, vol. 20, no. S6, e085971, Wiley, 2024, doi:10.1002/alz.085971. short: O. Petrova, S.A. Trushin, T.K.O. Nguyen, M. Ostroot, M. Schellenberg, G. Johnson, E. Trushina, L.A. Sazanov, Structure‐activity Relationship Study of Neuroprotective Complex I Inhibitor CP2, Wiley, 2024. das_tickbox: '0' date_created: 2025-01-29T15:21:40Z date_published: 2024-12-01T00:00:00Z date_updated: 2026-10-16T08:42:53Z day: '01' ddc: - '570' department: - _id: LeSa doi: 10.1002/alz.085971 file: - access_level: open_access checksum: e914bd5f3a701659ab79d497a122811f content_type: application/pdf creator: dernst date_created: 2025-01-29T15:24:50Z date_updated: 2025-01-29T15:24:50Z file_id: '18968' file_name: 2024_AlzheimerDementia_Petrova.pdf file_size: 70870 relation: main_file success: 1 file_date_updated: 2025-01-29T15:24:50Z fulldoi: https://doi.org/10.1002/alz.085971 has_accepted_license: '1' intvolume: ' 20' issue: S6 language: - iso: eng month: '12' oa: 1 oa_version: Published Version publication: Alzheimer's & Dementia publication_identifier: eissn: - 1552-5279 issn: - 1552-5260 publication_status: published publisher: Wiley quality_controlled: '1' researchdata_availability: no status: public supplementarymaterial: no title: Structure‐activity relationship study of neuroprotective complex I inhibitor CP2 tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: other_academic_publication user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 20 year: '2024' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '18581' abstract: - lang: eng text: "Background: Human induced pluripotent stem cells represent a scalable source of youthful tissue progenitors and secretomes for regenerative therapies. The aim of our study was to investigate the potential of conditioned medium (CM) from hiPSC-mesenchymal progenitors (hiPSC-MPs) to stimulate osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells (MSCs). We also investigated whether prolonged cultivation or osteogenic pre-differentiation of hiPSC-MPs could enhance the stimulatory activity of CM.\r\nMethods: MSCs were isolated from 13 donors (age 20–90 years). CM derived from hiPSC-MPs was added to the MSC cultures and the effects on proliferation and osteogenic differentiation were examined after 14 days and 6 weeks. The stimulatory activity of hiPSC-MP-CM was compared with the activity of MSC-derived CM and with the activity of CM prepared from hiPSC-MPs pre-cultured in growth or osteogenic medium for 14 days. Comparative proteomic analysis of CM was performed to gain insight into the molecular components responsible for the stimulatory activity.\r\nResults: Primary bone marrow-derived MSC exhibited variability, with a tendency towards lower proliferation and tri-lineage differentiation in older donors. hiPSC-MP-CM increased the proliferation and alkaline phosphatase activity of MSC from several adult/aged donors after 14 days of continuous supplementation under osteogenic conditions. However, CM supplementation failed to improve the mineralization of MSC pellets after 6 weeks under osteogenic conditions. hiPSC-MP-CM showed greater enhancement of proliferation and ALP activity than CM derived from bone marrow-derived MSCs. Moreover, 14-day cultivation but not osteogenic pre-differentiation of hiPSC-MPs strongly enhanced CM stimulatory activity. Quantitative proteomic analysis of d14-CM revealed a distinct profile of components that formed a highly interconnected associations network with two clusters, one functionally associated with binding and organization of actin/cytoskeletal components and the other with structural constituents of the extracellular matrix, collagen, and growth factor binding. Several hub proteins were identified that were reported to have functions in cell-extracellular matrix interaction, osteogenic differentiation and development.\r\nConclusions: Our data show that hiPSC-MP-CM enhances early osteogenic differentiation of human bone marrow-derived MSCs and that prolonged cultivation of hiPSC-MPs enhances CM-stimulatory activity. Proteomic analysis of the upregulated protein components provides the basis for further optimization of hiPSC-MP-CM for bone regenerative therapies." acknowledgement: "We thank the personnel of the Lorenz-Böhler-Unfallkrankenhaus for providing the human tissue waste for primary cell isolation and the New York Stem Cell Foundation Research Institute for providing the human induced pluripotent stem cell line 1013 A and its mesenchymal progenitors. We also thank all our colleagues at the Ludwig Boltzmann Institute for Traumatology for their suggestions and ongoing support of the project. InstaText writing tool (https://instatext.io) was used to edit the English language of the final manuscript.\r\nThis work has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie actions (grant agreement No. 657716) and the Transforming European Industry call H2020-NMBP-TRIND-2020 (grant agreement No. 953134), as well as by the FFG Industrienahe Dissertation program (grant agreement No. 867803 and 853056), the FEMtech Praktika program (grant agreement No. 852154, 868917 and 877951) and the Production of the Future program (grant agreement No. 877452)." article_number: '434' article_processing_charge: Yes article_type: original author: - first_name: Darja full_name: Marolt Presen, Darja last_name: Marolt Presen - first_name: Vanessa full_name: Goeschl, Vanessa last_name: Goeschl - first_name: Dominik full_name: Hanetseder, Dominik last_name: Hanetseder - first_name: Laura full_name: Ogrin, Laura last_name: Ogrin - first_name: Alexandra Larissa full_name: Stetco, Alexandra Larissa last_name: Stetco - first_name: Anja full_name: Tansek, Anja last_name: Tansek - first_name: Laura full_name: Pozenel, Laura last_name: Pozenel - first_name: Bella full_name: Bruszel, Bella id: 70abbbb3-88ea-11ec-8e0a-e8c939944834 last_name: Bruszel - first_name: Goran full_name: Mitulovic, Goran last_name: Mitulovic - first_name: Johannes full_name: Oesterreicher, Johannes last_name: Oesterreicher - first_name: Johannes full_name: Zipperle, Johannes last_name: Zipperle - first_name: Barbara full_name: Schaedl, Barbara last_name: Schaedl - first_name: Wolfgang full_name: Holnthoner, Wolfgang last_name: Holnthoner - first_name: Johannes full_name: Grillari, Johannes last_name: Grillari - first_name: Heinz full_name: Redl, Heinz last_name: Redl citation: ama: Marolt Presen D, Goeschl V, Hanetseder D, et al. Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium. Stem Cell Research and Therapy. 2024;15. doi:10.1186/s13287-024-03960-5 apa: Marolt Presen, D., Goeschl, V., Hanetseder, D., Ogrin, L., Stetco, A. L., Tansek, A., … Redl, H. (2024). Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium. Stem Cell Research and Therapy. Springer Nature. https://doi.org/10.1186/s13287-024-03960-5 chicago: Marolt Presen, Darja, Vanessa Goeschl, Dominik Hanetseder, Laura Ogrin, Alexandra Larissa Stetco, Anja Tansek, Laura Pozenel, et al. “Prolonged Cultivation Enhances the Stimulatory Activity of HiPSC Mesenchymal Progenitor-Derived Conditioned Medium.” Stem Cell Research and Therapy. Springer Nature, 2024. https://doi.org/10.1186/s13287-024-03960-5. ieee: D. Marolt Presen et al., “Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium,” Stem Cell Research and Therapy, vol. 15. Springer Nature, 2024. ista: Marolt Presen D, Goeschl V, Hanetseder D, Ogrin L, Stetco AL, Tansek A, Pozenel L, Bruszel B, Mitulovic G, Oesterreicher J, Zipperle J, Schaedl B, Holnthoner W, Grillari J, Redl H. 2024. Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium. Stem Cell Research and Therapy. 15, 434. mla: Marolt Presen, Darja, et al. “Prolonged Cultivation Enhances the Stimulatory Activity of HiPSC Mesenchymal Progenitor-Derived Conditioned Medium.” Stem Cell Research and Therapy, vol. 15, 434, Springer Nature, 2024, doi:10.1186/s13287-024-03960-5. short: D. Marolt Presen, V. Goeschl, D. Hanetseder, L. Ogrin, A.L. Stetco, A. Tansek, L. Pozenel, B. Bruszel, G. Mitulovic, J. Oesterreicher, J. Zipperle, B. Schaedl, W. Holnthoner, J. Grillari, H. Redl, Stem Cell Research and Therapy 15 (2024). das_tickbox: '1' dataavailabilitystatement: All data generated and analysed during this study are included in this published article and its supplementary information files. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD052766 (access details are provided in Suppl. Data File 1). The raw datasets used and/or analysed during the current study are available from the corresponding author on reasonable request. date_created: 2024-11-24T23:01:47Z date_published: 2024-12-01T00:00:00Z date_updated: 2026-10-16T08:56:29Z day: '01' ddc: - '570' department: - _id: LifeSc doi: 10.1186/s13287-024-03960-5 external_id: isi: - '001356479400001' pmid: - '39551765' file: - access_level: open_access checksum: 91edba8edde30d781dce89fdd5cadc39 content_type: application/pdf creator: dernst date_created: 2024-12-10T08:28:17Z date_updated: 2024-12-10T08:28:17Z file_id: '18641' file_name: 2024_StemCellResearch_Presen.pdf file_size: 6690494 relation: main_file success: 1 file_date_updated: 2024-12-10T08:28:17Z fulldoi: https://doi.org/10.1186/s13287-024-03960-5 has_accepted_license: '1' intvolume: ' 15' isi: 1 language: - iso: eng month: '12' oa: 1 oa_version: Published Version pmid: 1 publication: Stem Cell Research and Therapy publication_identifier: eissn: - 1757-6512 publication_status: published publisher: Springer Nature quality_controlled: '1' researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: yes title: Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 15 year: '2024' ... --- OA_place: publisher OA_type: hybrid _id: '18904' abstract: - lang: eng text: The Planetary Transits and Oscillations of stars mission (PLATO) will allow us to measure surface rotation and monitor photometric activity of tens of thousands of main sequence solar-type and subgiant stars. This paper is the first of a series dedicated to the preparation of the analysis of stellar surface rotation and photospheric activity with the near-future PLATO data. We describe in this work the strategy that will be implemented in the PLATO pipeline to measure stellar surface rotation, photometric activity, and long-term modulations. The algorithms are applied on both noise-free and noisy simulations of solar-type stars, which include activity cycles, latitudinal differential rotation, and spot evolution. PLATO simulated systematics are included in the noisy light curves. We show that surface rotation periods can be recovered with confidence for most of the stars with only six months of observations and that the recovery rate of the analysis significantly improves as additional observations are collected. This means that the first PLATO data release will already provide a substantial set of measurements for this quantity, with a significant refinement on their quality as the instrument obtains longer light curves. Measuring the Schwabe-like magnetic activity cycle during the mission will require that the same field be observed over a significant timescale (more than four years). Nevertheless, PLATO will provide a vast and robust sample of solar-type stars with constraints on the activity-cycle length. Such a sample is lacking from previous missions dedicated to space photometry. acknowledgement: 'This work presents results from the European Space Agency (ESA) space mission PLATO. The PLATO payload, the PLATO Ground Segment and PLATO data processing are joint developments of ESA and the PLATO Mission Consortium (PMC). Funding for the PMC is provided at national levels, in particular by countries participating in the PLATO Multilateral Agreement (Austria, Belgium, Czech Republic, Denmark, France, Germany, Italy, Netherlands, Portugal, Spain, Sweden, Switzerland, Norway, and United Kingdom) and institutions from Brazil. Members of the PLATO Consortium can be found at https://platomission.com. The ESA PLATO mission website is https://www.cosmos.esa.int/plato. The authors thank the teams working for PLATO for all their work. They acknowledge the critical reading and the constructive comments from the anonymous referee that significantly allowed improving the original version of this paper. They finally thank R. Samadi for helpful advice and suggestions concerning the PSLS abilities. S.N.B, A.F.L, S.Me, I.P and E.C acknowledge support from PLATO ASI-INAF agreement no. 2022-28-HH.0 “PLATO Fase D”. S.N.B, L.A, A.S.B, Q.N, and A.S acknowledge financial support by ERC Whole Sun Synergy grant #810218. S.N.B, R.A.G, L.A, A.S.B, Q.N., D.B.P, E.P, and A.S acknowledge the support from PLATO CNES grant. R.A.G, D.B.P, and E.P acknowledge the support from SoHO/GOLF CNES grant. A.S.B, Q.N, and A.S acknowledge the support from INSU/PNST grant and Solar Orbiter CNES grant. A.S acknowledges funding from from the European Union’s Horizon-2020 research and innovation program (grant agreement no. 776403 ExoplANETS-A) and the Programme National de Planétologie (PNP). A.R.G.S acknowledges the support from the FCT through national funds and FEDER through COMPETE2020 (UIDB/04434/2020, UIDP/04434/2020, 2022.03993.PTDC) and the support from the FCT through the work contract No. 2020.02480.CEECIND/CP1631/CT0001. S.Ma acknowledges support from the Spanish Ministry of Science and Innovation (MICINN) with the Ramón y Cajal fellowship no. RYC-2015-17697 and through AEI under the Severo Ochoa Centres of Excellence Programme 2020–2023 (CEX2019-000920-S). S.Ma acknowledges support from the Spanish Ministry of Science and Innovation (MICINN) with the grant no. PID2019-107187GB-I00. M.J.G., K.B., R.M.O, J.P, O.R., C.R. acknowledge support from CNES. The computations were performed with the IRFU/CEA Saclay server facilities, funded by ERC Synergy grant WholeSun No.810218, the P2IO Labex emergence project FlarePredict, and CNES PLATO funds. Software:star-privateer (this work), pyspot (Aigrain et al. 2015), PSLS (Samadi et al. 2019), numpy (Harris et al. 2020), matplotlib (Hunter 2007), scipy (Virtanen et al. 2020), astropy (Astropy Collaboration 2022), pandas (Wes McKinney 2010; The pandas development team 2020), scikit-learn (Pedregosa et al. 2011).' article_number: A229 article_processing_charge: No article_type: original arxiv: 1 author: - first_name: S. N. full_name: Breton, S. N. last_name: Breton - first_name: A. F. full_name: Lanza, A. F. last_name: Lanza - first_name: S. full_name: Messina, S. last_name: Messina - first_name: I. full_name: Pagano, I. last_name: Pagano - first_name: Lisa Annabelle full_name: Bugnet, Lisa Annabelle id: d9edb345-f866-11ec-9b37-d119b5234501 last_name: Bugnet orcid: 0000-0003-0142-4000 - first_name: E. full_name: Corsaro, E. last_name: Corsaro - first_name: R. A. full_name: García, R. A. last_name: García - first_name: S. full_name: Mathur, S. last_name: Mathur - first_name: A. R. G. full_name: Santos, A. R. G. last_name: Santos - first_name: S. full_name: Aigrain, S. last_name: Aigrain - first_name: L. full_name: Amard, L. last_name: Amard - first_name: A. S. full_name: Brun, A. S. last_name: Brun - first_name: L. full_name: Degott, L. last_name: Degott - first_name: Q. full_name: Noraz, Q. last_name: Noraz - first_name: D. B. full_name: Palakkatharappil, D. B. last_name: Palakkatharappil - first_name: E. full_name: Panetier, E. last_name: Panetier - first_name: A. full_name: Strugarek, A. last_name: Strugarek - first_name: K. full_name: Belkacem, K. last_name: Belkacem - first_name: M.-J full_name: Goupil, M.-J last_name: Goupil - first_name: R. M. full_name: Ouazzani, R. M. last_name: Ouazzani - first_name: J. full_name: Philidet, J. last_name: Philidet - first_name: C. full_name: Renié, C. last_name: Renié - first_name: O. full_name: Roth, O. last_name: Roth citation: ama: Breton SN, Lanza AF, Messina S, et al. Measuring stellar surface rotation and activity with the PLATO mission. I. Strategy and application to simulated light curves. Astronomy & Astrophysics. 2024;689. doi:10.1051/0004-6361/202449893 apa: Breton, S. N., Lanza, A. F., Messina, S., Pagano, I., Bugnet, L. A., Corsaro, E., … Roth, O. (2024). Measuring stellar surface rotation and activity with the PLATO mission. I. Strategy and application to simulated light curves. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202449893 chicago: Breton, S. N., A. F. Lanza, S. Messina, I. Pagano, Lisa Annabelle Bugnet, E. Corsaro, R. A. García, et al. “Measuring Stellar Surface Rotation and Activity with the PLATO Mission. I. Strategy and Application to Simulated Light Curves.” Astronomy & Astrophysics. EDP Sciences, 2024. https://doi.org/10.1051/0004-6361/202449893. ieee: S. N. Breton et al., “Measuring stellar surface rotation and activity with the PLATO mission. I. Strategy and application to simulated light curves,” Astronomy & Astrophysics, vol. 689. EDP Sciences, 2024. ista: Breton SN, Lanza AF, Messina S, Pagano I, Bugnet LA, Corsaro E, García RA, Mathur S, Santos ARG, Aigrain S, Amard L, Brun AS, Degott L, Noraz Q, Palakkatharappil DB, Panetier E, Strugarek A, Belkacem K, Goupil M-J, Ouazzani RM, Philidet J, Renié C, Roth O. 2024. Measuring stellar surface rotation and activity with the PLATO mission. I. Strategy and application to simulated light curves. Astronomy & Astrophysics. 689, A229. mla: Breton, S. N., et al. “Measuring Stellar Surface Rotation and Activity with the PLATO Mission. I. Strategy and Application to Simulated Light Curves.” Astronomy & Astrophysics, vol. 689, A229, EDP Sciences, 2024, doi:10.1051/0004-6361/202449893. short: S.N. Breton, A.F. Lanza, S. Messina, I. Pagano, L.A. Bugnet, E. Corsaro, R.A. García, S. Mathur, A.R.G. Santos, S. Aigrain, L. Amard, A.S. Brun, L. Degott, Q. Noraz, D.B. Palakkatharappil, E. Panetier, A. Strugarek, K. Belkacem, M.-J. Goupil, R.M. Ouazzani, J. Philidet, C. Renié, O. Roth, Astronomy & Astrophysics 689 (2024). das_tickbox: '0' date_created: 2025-01-27T13:12:44Z date_published: 2024-09-01T00:00:00Z date_updated: 2026-10-16T08:55:46Z day: '01' ddc: - '520' department: - _id: LiBu doi: 10.1051/0004-6361/202449893 external_id: arxiv: - '2407.03709' isi: - '001366206400007' file: - access_level: open_access checksum: 5c871ba7370a507ed6ea9fb2304d8263 content_type: application/pdf creator: dernst date_created: 2025-01-27T13:18:41Z date_updated: 2025-01-27T13:18:41Z file_id: '18905' file_name: 2024_AstronomyAstrophysics_Breton.pdf file_size: 6212007 relation: main_file success: 1 file_date_updated: 2025-01-27T13:18:41Z fulldoi: https://doi.org/10.1051/0004-6361/202449893 has_accepted_license: '1' intvolume: ' 689' isi: 1 language: - iso: eng month: '09' oa: 1 oa_version: Published Version publication: Astronomy & Astrophysics publication_identifier: eissn: - 1432-0746 issn: - 0004-6361 publication_status: published publisher: EDP Sciences quality_controlled: '1' researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: yes title: Measuring stellar surface rotation and activity with the PLATO mission. I. Strategy and application to simulated light curves tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 689 year: '2024' ...