---
DOAJ_listed: '1'
OA_place: repository
OA_type: gold
_id: '18655'
abstract:
- lang: eng
  text: "Let Qd be the d-dimensional binary hypercube. We say that P={v1,…,vk} is
    an increasing path of length k−1 in Qd, if for every i∈[k−1] the edge vivi+1 is
    obtained by switching some zero coordinate in vi to a one coordinate in vi+1.\r\nForm
    a random subgraph Qdp by retaining each edge in E(Qd) independently with probability
    p. We show that there is a phase transition with respect to the length of a longest
    increasing path around p=ed. Let α be a constant and let p=αd. When α<e, then
    there exists a δ∈[0,1) such that whp a longest increasing path in Qdp is of length
    at most δd. On the other hand, when α>e, whp there is a path of length d−2 in
    Qdp, and in fact, whether it is of length d−2,d−1, or d depends on whether the
    all-zero and all-one vertices percolate or not."
acknowledgement: "Research supported by the European Union’s Horizon 2020 research
  and innovation programme under the Marie Skłodowska-Curie grant agreement No. 101034413.\r\nThe
  authors wish to thank Ross Pinsky for his comments on an earlier version of the
  paper, and for bringing reference [12] to our attention. The authors are grateful
  to the anonymous referees for their helpful comments and suggestions."
article_number: '70'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Michael
  full_name: Anastos, Michael
  id: 0b2a4358-bb35-11ec-b7b9-e3279b593dbb
  last_name: Anastos
- first_name: Sahar
  full_name: Diskin, Sahar
  last_name: Diskin
- first_name: Dor
  full_name: Elboim, Dor
  last_name: Elboim
- first_name: Michael
  full_name: Krivelevich, Michael
  last_name: Krivelevich
citation:
  ama: Anastos M, Diskin S, Elboim D, Krivelevich M. Climbing up a random subgraph
    of the hypercube. <i>Electronic Communications in Probability</i>. 2024;29. doi:<a
    href="https://doi.org/10.1214/24-ECP639">10.1214/24-ECP639</a>
  apa: Anastos, M., Diskin, S., Elboim, D., &#38; Krivelevich, M. (2024). Climbing
    up a random subgraph of the hypercube. <i>Electronic Communications in Probability</i>.
    Duke University Press. <a href="https://doi.org/10.1214/24-ECP639">https://doi.org/10.1214/24-ECP639</a>
  chicago: Anastos, Michael, Sahar Diskin, Dor Elboim, and Michael Krivelevich. “Climbing
    up a Random Subgraph of the Hypercube.” <i>Electronic Communications in Probability</i>.
    Duke University Press, 2024. <a href="https://doi.org/10.1214/24-ECP639">https://doi.org/10.1214/24-ECP639</a>.
  ieee: M. Anastos, S. Diskin, D. Elboim, and M. Krivelevich, “Climbing up a random
    subgraph of the hypercube,” <i>Electronic Communications in Probability</i>, vol.
    29. Duke University Press, 2024.
  ista: Anastos M, Diskin S, Elboim D, Krivelevich M. 2024. Climbing up a random subgraph
    of the hypercube. Electronic Communications in Probability. 29, 70.
  mla: Anastos, Michael, et al. “Climbing up a Random Subgraph of the Hypercube.”
    <i>Electronic Communications in Probability</i>, vol. 29, 70, Duke University
    Press, 2024, doi:<a href="https://doi.org/10.1214/24-ECP639">10.1214/24-ECP639</a>.
  short: M. Anastos, S. Diskin, D. Elboim, M. Krivelevich, Electronic Communications
    in Probability 29 (2024).
corr_author: '1'
das_tickbox: '0'
date_created: 2024-12-15T23:01:51Z
date_published: 2024-11-24T00:00:00Z
date_updated: 2026-10-16T10:13:13Z
day: '24'
ddc:
- '510'
department:
- _id: MaKw
doi: 10.1214/24-ECP639
ec_funded: 1
external_id:
  arxiv:
  - '2311.16631'
  isi:
  - '001356019700001'
file:
- access_level: open_access
  checksum: 307a9d049325e6ca9bfe8b4a1f275983
  content_type: application/pdf
  creator: dernst
  date_created: 2024-12-16T07:33:34Z
  date_updated: 2024-12-16T07:33:34Z
  file_id: '18657'
  file_name: 2024_ElectrCommProbability_Anastos.pdf
  file_size: 530169
  relation: main_file
  success: 1
file_date_updated: 2024-12-16T07:33:34Z
fulldoi: https://doi.org/10.1214/24-ECP639
has_accepted_license: '1'
intvolume: '        29'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2311.16631
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
publication: Electronic Communications in Probability
publication_identifier:
  eissn:
  - 1083-589X
publication_status: published
publisher: Duke University Press
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Climbing up a random subgraph of the hypercube
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 29
year: '2024'
...
---
DOAJ_listed: '1'
OA_place: repository
OA_type: gold
_id: '18951'
abstract:
- lang: eng
  text: "We consider local dynamics of the dimer model (perfect matchings) on hypercubic
    boxes [n] \r\nd . These consist of successively switching the dimers along alternating
    cycles of prescribed (small) lengths. We study the connectivity properties of
    the dimer configuration space equipped with these transitions. Answering a question
    of Freire, Klivans, Milet, and Saldanha, we show that in three dimensions any
    configuration admits an alternating cycle of length at most 6. We further establish
    that any configuration on [n] d  features order n d−2  alternating cycles of length
    at most 4d−2. We also prove that the dynamics of dimer configurations on the unit
    hypercube of dimension d is ergodic when switching alternating cycles of length
    at most 4d−4. Finally, in the planar but non-bipartite case, we show that parallelogram-shaped
    boxes in the triangular lattice are ergodic for switching alternating cycles of
    lengths 4 and 6 only, thus improving a result of Kenyon and Rémila, which also
    uses 8-cycles. None of our proofs make reference to height functions."
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Ivailo
  full_name: Hartarsky, Ivailo
  last_name: Hartarsky
- first_name: Lyuben
  full_name: Lichev, Lyuben
  id: 9aa8388e-d003-11ee-8458-c4c1d7447977
  last_name: Lichev
- first_name: Fabio Lucio
  full_name: Toninelli, Fabio Lucio
  last_name: Toninelli
citation:
  ama: Hartarsky I, Lichev L, Toninelli FL. Local dimer dynamics in higher dimensions.
    <i>Annales de l’Institut Henri Poincaré D, Combinatorics, Physics and their Interactions</i>.
    2024. doi:<a href="https://doi.org/10.4171/aihpd/200">10.4171/aihpd/200</a>
  apa: Hartarsky, I., Lichev, L., &#38; Toninelli, F. L. (2024). Local dimer dynamics
    in higher dimensions. <i>Annales de l’Institut Henri Poincaré D, Combinatorics,
    Physics and Their Interactions</i>. EMS Press. <a href="https://doi.org/10.4171/aihpd/200">https://doi.org/10.4171/aihpd/200</a>
  chicago: Hartarsky, Ivailo, Lyuben Lichev, and Fabio Lucio Toninelli. “Local Dimer
    Dynamics in Higher Dimensions.” <i>Annales de l’Institut Henri Poincaré D, Combinatorics,
    Physics and Their Interactions</i>. EMS Press, 2024. <a href="https://doi.org/10.4171/aihpd/200">https://doi.org/10.4171/aihpd/200</a>.
  ieee: I. Hartarsky, L. Lichev, and F. L. Toninelli, “Local dimer dynamics in higher
    dimensions,” <i>Annales de l’Institut Henri Poincaré D, Combinatorics, Physics
    and their Interactions</i>. EMS Press, 2024.
  ista: Hartarsky I, Lichev L, Toninelli FL. 2024. Local dimer dynamics in higher
    dimensions. Annales de l’Institut Henri Poincaré D, Combinatorics, Physics and
    their Interactions.
  mla: Hartarsky, Ivailo, et al. “Local Dimer Dynamics in Higher Dimensions.” <i>Annales
    de l’Institut Henri Poincaré D, Combinatorics, Physics and Their Interactions</i>,
    EMS Press, 2024, doi:<a href="https://doi.org/10.4171/aihpd/200">10.4171/aihpd/200</a>.
  short: I. Hartarsky, L. Lichev, F.L. Toninelli, Annales de l’Institut Henri Poincaré
    D, Combinatorics, Physics and Their Interactions (2024).
das_tickbox: '1'
date_created: 2025-01-29T10:57:09Z
date_published: 2024-08-26T00:00:00Z
date_updated: 2026-10-16T10:14:21Z
day: '26'
department:
- _id: MaKw
doi: 10.4171/aihpd/200
external_id:
  arxiv:
  - '2304.10930'
fulldoi: https://doi.org/10.4171/aihpd/200
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2304.10930
mathsc:
- 05B50
- 05C70
- 82C20
month: '08'
oa: 1
oa_version: Preprint
publication: Annales de l’Institut Henri Poincaré D, Combinatorics, Physics and their
  Interactions
publication_identifier:
  eissn:
  - 2308-5835
  issn:
  - 2308-5827
publication_status: epub_ahead
publisher: EMS Press
quality_controlled: '1'
researchdata_availability: unclear
scopus_import: '1'
status: public
supplementarymaterial: unclear
title: Local dimer dynamics in higher dimensions
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '18559'
abstract:
- lang: eng
  text: We prove a 1973 conjecture due to Erdős on the existence of Steiner triple
    systems with arbitrarily high girth.
acknowledgement: Sah and Sawhney were supported by NSF Graduate Research Fellowship
  Program DGE1745302. Sah was supported by the PD Soros Fellowship. Simkin was supported
  by the Center of Mathematical Sciences and Applications at Harvard University.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Matthew Alan
  full_name: Kwan, Matthew Alan
  id: 5fca0887-a1db-11eb-95d1-ca9d5e0453b3
  last_name: Kwan
  orcid: 0000-0002-4003-7567
- first_name: Ashwin
  full_name: Sah, Ashwin
  last_name: Sah
- first_name: Mehtaab
  full_name: Sawhney, Mehtaab
  last_name: Sawhney
- first_name: Michael
  full_name: Simkin, Michael
  last_name: Simkin
citation:
  ama: Kwan MA, Sah A, Sawhney M, Simkin M. High-girth Steiner triple systems. <i>Annals
    of Mathematics</i>. 2024;200(3):1059-1156. doi:<a href="https://doi.org/10.4007/annals.2024.200.3.4">10.4007/annals.2024.200.3.4</a>
  apa: Kwan, M. A., Sah, A., Sawhney, M., &#38; Simkin, M. (2024). High-girth Steiner
    triple systems. <i>Annals of Mathematics</i>. Princeton University. <a href="https://doi.org/10.4007/annals.2024.200.3.4">https://doi.org/10.4007/annals.2024.200.3.4</a>
  chicago: Kwan, Matthew Alan, Ashwin Sah, Mehtaab Sawhney, and Michael Simkin. “High-Girth
    Steiner Triple Systems.” <i>Annals of Mathematics</i>. Princeton University, 2024.
    <a href="https://doi.org/10.4007/annals.2024.200.3.4">https://doi.org/10.4007/annals.2024.200.3.4</a>.
  ieee: M. A. Kwan, A. Sah, M. Sawhney, and M. Simkin, “High-girth Steiner triple
    systems,” <i>Annals of Mathematics</i>, vol. 200, no. 3. Princeton University,
    pp. 1059–1156, 2024.
  ista: Kwan MA, Sah A, Sawhney M, Simkin M. 2024. High-girth Steiner triple systems.
    Annals of Mathematics. 200(3), 1059–1156.
  mla: Kwan, Matthew Alan, et al. “High-Girth Steiner Triple Systems.” <i>Annals of
    Mathematics</i>, vol. 200, no. 3, Princeton University, 2024, pp. 1059–156, doi:<a
    href="https://doi.org/10.4007/annals.2024.200.3.4">10.4007/annals.2024.200.3.4</a>.
  short: M.A. Kwan, A. Sah, M. Sawhney, M. Simkin, Annals of Mathematics 200 (2024)
    1059–1156.
corr_author: '1'
das_tickbox: '0'
date_created: 2024-11-17T23:01:48Z
date_published: 2024-11-01T00:00:00Z
date_updated: 2026-10-16T10:12:22Z
day: '01'
department:
- _id: MaKw
doi: 10.4007/annals.2024.200.3.4
external_id:
  arxiv:
  - '2201.04554'
  isi:
  - '001366233800004'
fulldoi: https://doi.org/10.4007/annals.2024.200.3.4
intvolume: '       200'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2201.04554
month: '11'
oa: 1
oa_version: Preprint
page: 1059-1156
publication: Annals of Mathematics
publication_identifier:
  eissn:
  - 1939-8980
  issn:
  - 0003-486X
publication_status: published
publisher: Princeton University
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: High-girth Steiner triple systems
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 200
year: '2024'
...
---
OA_place: publisher
OA_type: hybrid
_id: '18938'
abstract:
- lang: eng
  text: The synthesis of proteins as encoded in the genome depends critically on translational
    fidelity. Nevertheless, errors inevitably occur, and those that result in reading
    frame shifts are particularly consequential because the resulting polypeptides
    are typically nonfunctional. Despite the generally maladaptive impact of such
    errors, the proper decoding of certain mRNAs, including many viral mRNAs, depends
    on a process known as programmed ribosomal frameshifting. The fact that these
    programmed events, commonly involving a shift to the –1 frame, occur at specific
    evolutionarily optimized “slippery” sites has facilitated mechanistic investigation.
    By contrast, less is known about the scope and nature of error (i.e., nonprogrammed)
    frameshifting. Here, we examine error frameshifting by monitoring spontaneous
    frameshift events that suppress the effects of single base pair deletions affecting
    two unrelated test proteins. To map the precise sites of frameshifting, we developed
    a targeted mass spectrometry–based method called “translational tiling proteomics”
    for interrogating the full set of possible –1 slippage events that could produce
    the observed frameshift suppression. Surprisingly, such events occur at many sites
    along the transcripts, involving up to one half of the available codons. Only
    a subset of these resembled canonical “slippery” sites, implicating alternative
    mechanisms potentially involving noncognate mispairing events. Additionally, the
    aggregate frequency of these events (ranging from 1 to 10% in our test cases)
    was higher than we might have anticipated. Our findings point to an unexpected
    degree of mechanistic diversity among ribosomal frameshifting events and suggest
    that frameshifted products may contribute more significantly to the proteome than
    generally assumed.
acknowledgement: We thank S. L. Dove for valuable discussion and comments on the manuscript
  and R. Hellmiss for artwork. This work was supported by NIH grants GM136247 to A.H.,
  AG011085 to J.W.H., and GM132129 to J.A.P.
article_number: e2317453121
article_processing_charge: No
article_type: original
author:
- first_name: Benjamin L
  full_name: Springstein, Benjamin L
  id: b4eb62ef-ac72-11ed-9503-ed3b4d66c083
  last_name: Springstein
  orcid: 0000-0002-3461-5391
- first_name: Joao A.
  full_name: Paulo, Joao A.
  last_name: Paulo
- first_name: Hankum
  full_name: Park, Hankum
  last_name: Park
- first_name: Kemardo
  full_name: Henry, Kemardo
  last_name: Henry
- first_name: Eleanor
  full_name: Fleming, Eleanor
  last_name: Fleming
- first_name: Zoë
  full_name: Feder, Zoë
  last_name: Feder
- first_name: J. Wade
  full_name: Harper, J. Wade
  last_name: Harper
- first_name: Ann
  full_name: Hochschild, Ann
  last_name: Hochschild
citation:
  ama: Springstein BL, Paulo JA, Park H, et al. Systematic analysis of nonprogrammed
    frameshift suppression in E.coli via translational tiling proteomics. <i>Proceedings
    of the National Academy of Sciences of the United States of America</i>. 2024;121(6).
    doi:<a href="https://doi.org/10.1073/pnas.2317453121">10.1073/pnas.2317453121</a>
  apa: Springstein, B. L., Paulo, J. A., Park, H., Henry, K., Fleming, E., Feder,
    Z., … Hochschild, A. (2024). Systematic analysis of nonprogrammed frameshift suppression
    in E.coli via translational tiling proteomics. <i>Proceedings of the National
    Academy of Sciences of the United States of America</i>. National Academy of Sciences.
    <a href="https://doi.org/10.1073/pnas.2317453121">https://doi.org/10.1073/pnas.2317453121</a>
  chicago: Springstein, Benjamin L, Joao A. Paulo, Hankum Park, Kemardo Henry, Eleanor
    Fleming, Zoë Feder, J. Wade Harper, and Ann Hochschild. “Systematic Analysis of
    Nonprogrammed Frameshift Suppression in E.Coli via Translational Tiling Proteomics.”
    <i>Proceedings of the National Academy of Sciences of the United States of America</i>.
    National Academy of Sciences, 2024. <a href="https://doi.org/10.1073/pnas.2317453121">https://doi.org/10.1073/pnas.2317453121</a>.
  ieee: B. L. Springstein <i>et al.</i>, “Systematic analysis of nonprogrammed frameshift
    suppression in E.coli via translational tiling proteomics,” <i>Proceedings of
    the National Academy of Sciences of the United States of America</i>, vol. 121,
    no. 6. National Academy of Sciences, 2024.
  ista: Springstein BL, Paulo JA, Park H, Henry K, Fleming E, Feder Z, Harper JW,
    Hochschild A. 2024. Systematic analysis of nonprogrammed frameshift suppression
    in E.coli via translational tiling proteomics. Proceedings of the National Academy
    of Sciences of the United States of America. 121(6), e2317453121.
  mla: Springstein, Benjamin L., et al. “Systematic Analysis of Nonprogrammed Frameshift
    Suppression in E.Coli via Translational Tiling Proteomics.” <i>Proceedings of
    the National Academy of Sciences of the United States of America</i>, vol. 121,
    no. 6, e2317453121, National Academy of Sciences, 2024, doi:<a href="https://doi.org/10.1073/pnas.2317453121">10.1073/pnas.2317453121</a>.
  short: B.L. Springstein, J.A. Paulo, H. Park, K. Henry, E. Fleming, Z. Feder, J.W.
    Harper, A. Hochschild, Proceedings of the National Academy of Sciences of the
    United States of America 121 (2024).
das_tickbox: '1'
dataavailabilitystatement: Key plasmids developed in this work will be deposited with
  Addgene; all other plasmids developed in this work will be made available upon request
  with no restrictions. Proteomic data (.RAW files) and SDRF (sample and data relationship
  format) files are available via ProteomeXchange with identifier PXD047675
date_created: 2025-01-29T08:39:27Z
date_published: 2024-02-06T00:00:00Z
date_updated: 2026-10-16T10:37:18Z
day: '06'
ddc:
- '570'
department:
- _id: MaLo
doi: 10.1073/pnas.2317453121
external_id:
  pmid:
  - '38289956'
file:
- access_level: open_access
  checksum: 5bd62c7cb4287e3706a1d45d6ef61fd1
  content_type: application/pdf
  creator: dernst
  date_created: 2025-01-29T08:43:16Z
  date_updated: 2025-01-29T08:43:16Z
  file_id: '18939'
  file_name: 2024_PNAS_Springstein.pdf
  file_size: 720902
  relation: main_file
  success: 1
file_date_updated: 2025-01-29T08:43:16Z
fulldoi: https://doi.org/10.1073/pnas.2317453121
has_accepted_license: '1'
intvolume: '       121'
issue: '6'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: Proceedings of the National Academy of Sciences of the United States
  of America
publication_identifier:
  eissn:
  - 1091-6490
  issn:
  - 0027-8424
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Systematic analysis of nonprogrammed frameshift suppression in E.coli via translational
  tiling proteomics
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 121
year: '2024'
...
---
OA_place: publisher
OA_type: gold
_id: '18073'
abstract:
- lang: eng
  text: Conserved signaling cascades monitor protein-folding homeostasis to ensure
    proper cellular function. One of the evolutionary conserved key players is IRE1,
    which maintains endoplasmic reticulum (ER) homeostasis through the unfolded protein
    response (UPR). Upon accumulation of misfolded proteins in the ER, IRE1 forms
    clusters on the ER membrane to initiate UPR signaling. What regulates IRE1 cluster
    formation is not fully understood. Here, we show that the ER lumenal domain (LD)
    of human IRE1α forms biomolecular condensates in vitro. IRE1α LD condensates were
    stabilized both by binding to unfolded polypeptides as well as by tethering to
    model membranes, suggesting their role in assembling IRE1α into signaling-competent
    stable clusters. Molecular dynamics simulations indicated that weak multivalent
    interactions drive IRE1α LD clustering. Mutagenesis experiments identified disordered
    regions in IRE1α LD to control its clustering in vitro and in cells. Importantly,
    dysregulated clustering of IRE1α mutants led to defects in IRE1α signaling. Our
    results revealed that disordered regions in IRE1α LD control its clustering and
    suggest their role as a common strategy in regulating protein assembly on membranes.
acknowledgement: We thank late Thomas Peterbauer at the Max Perutz Labs Biooptics
  Light Microscopy Facility for his help and support. We are grateful to Kitti Csalyi
  and Thomas Sauer at Max Perutz Labs Biooptics FACS facility for their help. We thank
  Grzegorz Scibisz and Sertan Atilla for their support with the expression and purification
  of mCherry-IRE1α LD-10His. We are grateful to Aleksandra S Anisimova with her help
  in the generation of stable cell lines and the statistical analyses of the data.
  We thank Venja Vieweger for her help with the characterization of the WLLI and D123P
  IRE1 mutants in cells. We are thankful to Monika Kubickova for the help with the
  AUC experiments. We acknowledge CF BIC of CIISB, Instruct-CZ Centre, supported by
  MEYS CR (LM2023042)) and European Regional Development Fund-Project, UP CIISB“ (No.
  CZ.02.1.01/0.0/0.0/18_046/0015974). We thank the members of the Karagöz lab for
  the critical reading and editing of the manuscript. We are thankful to our colleagues
  Diego Acosta-Alvear, Vladislav Belyy, Jirka Peschek, Yasin Dagdas, Javier Martinez,
  Sascha Martens and Alwin Köhler for their invaluable input on the manuscript. We
  are grateful to Life Science Editors, especially Katrina Woolcock for her useful
  edits and comments on the manuscript. We acknowledge funding from Austrian Science
  Fund (FWF-SFB F79 and FWF-W 1261) to GEK. PK acknowledges the support of the Max
  Perutz PhD fellowship. GAV is funded by Stand-Alone grants (P30231-B, P30415-B,
  P36572), Special Research Grant (SFB grant F79), and Doctoral School grant (DK grant
  W1261) from the Austrian Science Fund (FWF). ES and RC acknowledge support and funding
  by the Frankfurt Institute of Advanced Studies, the LOEWE Center for Multiscale
  Modelling in Life Sciences of the state of Hesse, the Collaborative Research Center
  1507 “Membrane-associated Protein Assemblies, Machineries, and Supercomplexes” (Project
  ID 450648163), and the International Max Planck Research School on Cellular Biophysics
  (to RC), the Center for Scientific Computing of the Goethe University and the Jülich
  Supercomputing Centre for computational resources and support.
article_processing_charge: Yes
article_type: original
author:
- first_name: Paulina
  full_name: Kettel, Paulina
  last_name: Kettel
- first_name: Laura
  full_name: Marosits, Laura
  last_name: Marosits
- first_name: Elena
  full_name: Spinetti, Elena
  last_name: Spinetti
- first_name: Michael
  full_name: Rechberger, Michael
  last_name: Rechberger
- first_name: Caterina
  full_name: Giannini, Caterina
  id: e3fdddd5-f6e0-11ea-865d-ca99ee6367f4
  last_name: Giannini
- first_name: Philipp
  full_name: Radler, Philipp
  id: 40136C2A-F248-11E8-B48F-1D18A9856A87
  last_name: Radler
  orcid: '0000-0001-9198-2182 '
- first_name: Isabell
  full_name: Niedermoser, Isabell
  last_name: Niedermoser
- first_name: Irmgard
  full_name: Fischer, Irmgard
  last_name: Fischer
- first_name: Gijs A.
  full_name: Versteeg, Gijs A.
  last_name: Versteeg
- first_name: Martin
  full_name: Loose, Martin
  id: 462D4284-F248-11E8-B48F-1D18A9856A87
  last_name: Loose
  orcid: 0000-0001-7309-9724
- first_name: Roberto
  full_name: Covino, Roberto
  last_name: Covino
- first_name: G. Elif
  full_name: Karagöz, G. Elif
  last_name: Karagöz
citation:
  ama: Kettel P, Marosits L, Spinetti E, et al. Disordered regions in the IRE1α ER
    lumenal domain mediate its stress-induced clustering. <i>EMBO Journal</i>. 2024;43(20):4668-4698.
    doi:<a href="https://doi.org/10.1038/s44318-024-00207-0">10.1038/s44318-024-00207-0</a>
  apa: Kettel, P., Marosits, L., Spinetti, E., Rechberger, M., Giannini, C., Radler,
    P., … Karagöz, G. E. (2024). Disordered regions in the IRE1α ER lumenal domain
    mediate its stress-induced clustering. <i>EMBO Journal</i>. Embo Press. <a href="https://doi.org/10.1038/s44318-024-00207-0">https://doi.org/10.1038/s44318-024-00207-0</a>
  chicago: Kettel, Paulina, Laura Marosits, Elena Spinetti, Michael Rechberger, Caterina
    Giannini, Philipp Radler, Isabell Niedermoser, et al. “Disordered Regions in the
    IRE1α ER Lumenal Domain Mediate Its Stress-Induced Clustering.” <i>EMBO Journal</i>.
    Embo Press, 2024. <a href="https://doi.org/10.1038/s44318-024-00207-0">https://doi.org/10.1038/s44318-024-00207-0</a>.
  ieee: P. Kettel <i>et al.</i>, “Disordered regions in the IRE1α ER lumenal domain
    mediate its stress-induced clustering,” <i>EMBO Journal</i>, vol. 43, no. 20.
    Embo Press, pp. 4668–4698, 2024.
  ista: Kettel P, Marosits L, Spinetti E, Rechberger M, Giannini C, Radler P, Niedermoser
    I, Fischer I, Versteeg GA, Loose M, Covino R, Karagöz GE. 2024. Disordered regions
    in the IRE1α ER lumenal domain mediate its stress-induced clustering. EMBO Journal.
    43(20), 4668–4698.
  mla: Kettel, Paulina, et al. “Disordered Regions in the IRE1α ER Lumenal Domain
    Mediate Its Stress-Induced Clustering.” <i>EMBO Journal</i>, vol. 43, no. 20,
    Embo Press, 2024, pp. 4668–98, doi:<a href="https://doi.org/10.1038/s44318-024-00207-0">10.1038/s44318-024-00207-0</a>.
  short: P. Kettel, L. Marosits, E. Spinetti, M. Rechberger, C. Giannini, P. Radler,
    I. Niedermoser, I. Fischer, G.A. Versteeg, M. Loose, R. Covino, G.E. Karagöz,
    EMBO Journal 43 (2024) 4668–4698.
das_tickbox: '1'
dataavailabilitystatement: 'All the raw data in this work has been deposited to Biostudies
  with the accession number: S-BIAD1023. One can access the data through the link
  below: https://www.ebi.ac.uk/biostudies/bioimages/studies/S-BIAD1023?key=426953ee-3da4-4cf4-a496-e607ce240aff.  The
  source data of this paper are collected in the following database record: biostudies:S-SCDT-10_1038-S44318-024-00207-0.'
date_created: 2024-09-15T22:01:42Z
date_published: 2024-10-15T00:00:00Z
date_updated: 2026-10-16T10:37:47Z
day: '15'
ddc:
- '570'
department:
- _id: MaLo
- _id: JiFr
doi: 10.1038/s44318-024-00207-0
external_id:
  isi:
  - '001306286100002'
  pmid:
  - '39232130'
file:
- access_level: open_access
  checksum: 04f4df1a561083f2846676442fc4eb3c
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  creator: dernst
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  file_name: 2024_Embo_Kettel.pdf
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has_accepted_license: '1'
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isi: 1
issue: '20'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 4668-4698
pmid: 1
publication: EMBO Journal
publication_identifier:
  eissn:
  - 1460-2075
  issn:
  - 0261-4189
publication_status: published
publisher: Embo Press
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Disordered regions in the IRE1α ER lumenal domain mediate its stress-induced
  clustering
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 43
year: '2024'
...
---
_id: '14834'
abstract:
- lang: eng
  text: Bacteria divide by binary fission. The protein machine responsible for this
    process is the divisome, a transient assembly of more than 30 proteins in and
    on the surface of the cytoplasmic membrane. Together, they constrict the cell
    envelope and remodel the peptidoglycan layer to eventually split the cell into
    two. For Escherichia coli, most molecular players involved in this process have
    probably been identified, but obtaining the quantitative information needed for
    a mechanistic understanding can often not be achieved from experiments in vivo
    alone. Since the discovery of the Z-ring more than 30 years ago, in vitro reconstitution
    experiments have been crucial to shed light on molecular processes normally hidden
    in the complex environment of the living cell. In this review, we summarize how
    rebuilding the divisome from purified components – or at least parts of it - have
    been instrumental to obtain the detailed mechanistic understanding of the bacterial
    cell division machinery that we have today.
acknowledgement: We acknowledge members of the Loose laboratory at ISTA for helpful
  discussions—in particular M. Kojic for his insightful comments. This work was supported
  by the Austrian Science Fund (FWF P34607) to M.L.
article_number: '151380'
article_processing_charge: Yes
article_type: review
author:
- first_name: Philipp
  full_name: Radler, Philipp
  id: 40136C2A-F248-11E8-B48F-1D18A9856A87
  last_name: Radler
  orcid: '0000-0001-9198-2182 '
- first_name: Martin
  full_name: Loose, Martin
  id: 462D4284-F248-11E8-B48F-1D18A9856A87
  last_name: Loose
  orcid: 0000-0001-7309-9724
citation:
  ama: 'Radler P, Loose M. A dynamic duo: Understanding the roles of FtsZ and FtsA
    for Escherichia coli cell division through in vitro approaches. <i>European Journal
    of Cell Biology</i>. 2024;103(1). doi:<a href="https://doi.org/10.1016/j.ejcb.2023.151380">10.1016/j.ejcb.2023.151380</a>'
  apa: 'Radler, P., &#38; Loose, M. (2024). A dynamic duo: Understanding the roles
    of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches.
    <i>European Journal of Cell Biology</i>. Elsevier. <a href="https://doi.org/10.1016/j.ejcb.2023.151380">https://doi.org/10.1016/j.ejcb.2023.151380</a>'
  chicago: 'Radler, Philipp, and Martin Loose. “A Dynamic Duo: Understanding the Roles
    of FtsZ and FtsA for Escherichia Coli Cell Division through in Vitro Approaches.”
    <i>European Journal of Cell Biology</i>. Elsevier, 2024. <a href="https://doi.org/10.1016/j.ejcb.2023.151380">https://doi.org/10.1016/j.ejcb.2023.151380</a>.'
  ieee: 'P. Radler and M. Loose, “A dynamic duo: Understanding the roles of FtsZ and
    FtsA for Escherichia coli cell division through in vitro approaches,” <i>European
    Journal of Cell Biology</i>, vol. 103, no. 1. Elsevier, 2024.'
  ista: 'Radler P, Loose M. 2024. A dynamic duo: Understanding the roles of FtsZ and
    FtsA for Escherichia coli cell division through in vitro approaches. European
    Journal of Cell Biology. 103(1), 151380.'
  mla: 'Radler, Philipp, and Martin Loose. “A Dynamic Duo: Understanding the Roles
    of FtsZ and FtsA for Escherichia Coli Cell Division through in Vitro Approaches.”
    <i>European Journal of Cell Biology</i>, vol. 103, no. 1, 151380, Elsevier, 2024,
    doi:<a href="https://doi.org/10.1016/j.ejcb.2023.151380">10.1016/j.ejcb.2023.151380</a>.'
  short: P. Radler, M. Loose, European Journal of Cell Biology 103 (2024).
corr_author: '1'
das_tickbox: '0'
date_created: 2024-01-18T08:16:43Z
date_published: 2024-03-01T00:00:00Z
date_updated: 2026-10-16T10:15:15Z
day: '01'
ddc:
- '570'
department:
- _id: MaLo
doi: 10.1016/j.ejcb.2023.151380
external_id:
  isi:
  - '001166216800001'
  pmid:
  - '38218128'
file:
- access_level: open_access
  checksum: 5d170abbc87585205c010657e4552360
  content_type: application/pdf
  creator: dernst
  date_created: 2024-07-16T12:07:20Z
  date_updated: 2024-07-16T12:07:20Z
  file_id: '17265'
  file_name: 2024_EJCB_Radler.pdf
  file_size: 9995304
  relation: main_file
  success: 1
file_date_updated: 2024-07-16T12:07:20Z
fulldoi: https://doi.org/10.1016/j.ejcb.2023.151380
has_accepted_license: '1'
intvolume: '       103'
isi: 1
issue: '1'
keyword:
- Cell Biology
- General Medicine
- Histology
- Pathology and Forensic Medicine
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: fc38323b-9c52-11eb-aca3-ff8afb4a011d
  grant_number: P34607
  name: In vitro reconstitution of bacterial cell division
publication: European Journal of Cell Biology
publication_identifier:
  issn:
  - 0171-9335
publication_status: published
publisher: Elsevier
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: 'A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli
  cell division through in vitro approaches'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 103
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '18702'
abstract:
- lang: eng
  text: 'In this work we prove lower bounds on the (communication) cost of maintaining
    a shared key among a dynamic group of users. Being “dynamic” means one can add
    and remove users from the group. This captures important protocols like multicast
    encryption (ME) and continuous group-key agreement (CGKA), which is the primitive
    underlying many group messaging applications. We prove our bounds in a combinatorial
    setting where the state of the protocol progresses in rounds. The state of the
    protocol in each round is captured by a set system, with each of its elements
    specifying a set of users who share a secret key. We show this combinatorial model
    implies bounds in symbolic models for ME and CGKA that capture, as building blocks,
    PRGs, PRFs, dual PRFs, secret sharing, and symmetric encryption in the setting
    of ME, and PRGs, PRFs, dual PRFs, secret sharing, public-key encryption, and key-updatable
    public-key encryption in the setting of CGKA. The models are related to the ones
    used by Micciancio and Panjwani (Eurocrypt’04) and Bienstock et al. (TCC’20) to
    analyze ME and CGKA, respectively. We prove – using the Bollobás’ Set Pairs Inequality
    – that the cost (number of uploaded ciphertexts) for replacing a set of d users
    in a group of size n is Ω(dln(n/d)). Our lower bound is asymptotically tight and
    both improves on a bound of Ω(d) by Bienstock et al. (TCC’20), and generalizes
    a result by Micciancio and Panjwani (Eurocrypt’04), who proved a lower bound of
    Ω(log(n)) for d=1. '
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Michael
  full_name: Anastos, Michael
  id: 0b2a4358-bb35-11ec-b7b9-e3279b593dbb
  last_name: Anastos
- first_name: Benedikt
  full_name: Auerbach, Benedikt
  id: D33D2B18-E445-11E9-ABB7-15F4E5697425
  last_name: Auerbach
  orcid: 0000-0002-7553-6606
- first_name: Mirza Ahad
  full_name: Baig, Mirza Ahad
  id: 3EDE6DE4-AA5A-11E9-986D-341CE6697425
  last_name: Baig
- first_name: Miguel
  full_name: Cueto Noval, Miguel
  id: ffc563a3-f6e0-11ea-865d-e3cce03d17cc
  last_name: Cueto Noval
  orcid: 0000-0002-2505-4246
- first_name: Matthew Alan
  full_name: Kwan, Matthew Alan
  id: 5fca0887-a1db-11eb-95d1-ca9d5e0453b3
  last_name: Kwan
  orcid: 0000-0002-4003-7567
- first_name: Guillermo
  full_name: Pascual Perez, Guillermo
  id: 2D7ABD02-F248-11E8-B48F-1D18A9856A87
  last_name: Pascual Perez
  orcid: 0000-0001-8630-415X
- first_name: Krzysztof Z
  full_name: Pietrzak, Krzysztof Z
  id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
  last_name: Pietrzak
  orcid: 0000-0002-9139-1654
citation:
  ama: 'Anastos M, Auerbach B, Baig MA, et al. The cost of maintaining keys in dynamic
    groups with applications to multicast encryption and group messaging. In: <i>22nd
    International Conference on Theory of Cryptography</i>. Vol 15364. Springer Nature;
    2024:413-443. doi:<a href="https://doi.org/10.1007/978-3-031-78011-0_14">10.1007/978-3-031-78011-0_14</a>'
  apa: 'Anastos, M., Auerbach, B., Baig, M. A., Cueto Noval, M., Kwan, M. A., Pascual
    Perez, G., &#38; Pietrzak, K. Z. (2024). The cost of maintaining keys in dynamic
    groups with applications to multicast encryption and group messaging. In <i>22nd
    International Conference on Theory of Cryptography</i> (Vol. 15364, pp. 413–443).
    Milan, Italy: Springer Nature. <a href="https://doi.org/10.1007/978-3-031-78011-0_14">https://doi.org/10.1007/978-3-031-78011-0_14</a>'
  chicago: Anastos, Michael, Benedikt Auerbach, Mirza Ahad Baig, Miguel Cueto Noval,
    Matthew Alan Kwan, Guillermo Pascual Perez, and Krzysztof Z Pietrzak. “The Cost
    of Maintaining Keys in Dynamic Groups with Applications to Multicast Encryption
    and Group Messaging.” In <i>22nd International Conference on Theory of Cryptography</i>,
    15364:413–43. Springer Nature, 2024. <a href="https://doi.org/10.1007/978-3-031-78011-0_14">https://doi.org/10.1007/978-3-031-78011-0_14</a>.
  ieee: M. Anastos <i>et al.</i>, “The cost of maintaining keys in dynamic groups
    with applications to multicast encryption and group messaging,” in <i>22nd International
    Conference on Theory of Cryptography</i>, Milan, Italy, 2024, vol. 15364, pp.
    413–443.
  ista: 'Anastos M, Auerbach B, Baig MA, Cueto Noval M, Kwan MA, Pascual Perez G,
    Pietrzak KZ. 2024. The cost of maintaining keys in dynamic groups with applications
    to multicast encryption and group messaging. 22nd International Conference on
    Theory of Cryptography. TCC: Theory of Cryptography, LNCS, vol. 15364, 413–443.'
  mla: Anastos, Michael, et al. “The Cost of Maintaining Keys in Dynamic Groups with Applications
    to Multicast Encryption and Group Messaging.” <i>22nd International Conference
    on Theory of Cryptography</i>, vol. 15364, Springer Nature, 2024, pp. 413–43,
    doi:<a href="https://doi.org/10.1007/978-3-031-78011-0_14">10.1007/978-3-031-78011-0_14</a>.
  short: M. Anastos, B. Auerbach, M.A. Baig, M. Cueto Noval, M.A. Kwan, G. Pascual
    Perez, K.Z. Pietrzak, in:, 22nd International Conference on Theory of Cryptography,
    Springer Nature, 2024, pp. 413–443.
conference:
  end_date: 2024-12-06
  location: Milan, Italy
  name: 'TCC: Theory of Cryptography'
  start_date: 2024-12-02
corr_author: '1'
das_tickbox: '0'
date_created: 2024-12-22T23:01:47Z
date_published: 2024-12-02T00:00:00Z
date_updated: 2026-10-16T10:14:41Z
day: '02'
department:
- _id: MaKw
- _id: KrPi
doi: 10.1007/978-3-031-78011-0_14
external_id:
  isi:
  - '001545628900014'
fulldoi: https://doi.org/10.1007/978-3-031-78011-0_14
intvolume: '     15364'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://eprint.iacr.org/2024/1097
month: '12'
oa: 1
oa_version: Preprint
page: 413-443
publication: 22nd International Conference on Theory of Cryptography
publication_identifier:
  eissn:
  - 1611-3349
  isbn:
  - '9783031780103'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
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  - id: '22664'
    relation: dissertation_contains
    status: public
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: The cost of maintaining keys in dynamic groups with applications to multicast
  encryption and group messaging
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 15364
year: '2024'
...
---
_id: '17475'
abstract:
- lang: eng
  text: "As a discrete analogue of Kac’s celebrated question on ‘hearing the shape
    of a drum’ and towards a practical\r\ngraph isomorphism test, it is of interest
    to understand which graphs are determined up to isomorphism by\r\ntheir spectrum
    (of their adjacency matrix). A striking conjecture in this area, due to van Dam
    and Haemers,\r\nis that ‘almost all graphs are determined by their spectrum’,
    meaning that the fraction of unlabelled n-vertex\r\ngraphs which are determined
    by their spectrum converges to 1 as n → ∞.\r\nIn this paper, we make a step towards
    this conjecture, showing that there are exponentially many n-vertex\r\ngraphs
    which are determined by their spectrum. This improves on previous bounds (of shape
    e\r\nc\r\n√\r\nn\r\n). We also\r\npropose a number of further directions of research.\r\n"
acknowledgement: Matthew Kwan was supported by ERC Starting Grant ‘RANDSTRUCT’ No.
  101076777.
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Illya
  full_name: Koval, Illya
  id: 2eed1f3b-896a-11ed-bdf8-93c7c4bf159e
  last_name: Koval
- first_name: Matthew Alan
  full_name: Kwan, Matthew Alan
  id: 5fca0887-a1db-11eb-95d1-ca9d5e0453b3
  last_name: Kwan
  orcid: 0000-0002-4003-7567
citation:
  ama: Koval I, Kwan MA. Exponentially many graphs are determined by their spectrum.
    <i>Quarterly Journal of Mathematics</i>. 2024;75(3):869-899. doi:<a href="https://doi.org/10.1093/qmath/haae030">10.1093/qmath/haae030</a>
  apa: Koval, I., &#38; Kwan, M. A. (2024). Exponentially many graphs are determined
    by their spectrum. <i>Quarterly Journal of Mathematics</i>. Oxford University
    Press. <a href="https://doi.org/10.1093/qmath/haae030">https://doi.org/10.1093/qmath/haae030</a>
  chicago: Koval, Illya, and Matthew Alan Kwan. “Exponentially Many Graphs Are Determined
    by Their Spectrum.” <i>Quarterly Journal of Mathematics</i>. Oxford University
    Press, 2024. <a href="https://doi.org/10.1093/qmath/haae030">https://doi.org/10.1093/qmath/haae030</a>.
  ieee: I. Koval and M. A. Kwan, “Exponentially many graphs are determined by their
    spectrum,” <i>Quarterly Journal of Mathematics</i>, vol. 75, no. 3. Oxford University
    Press, pp. 869–899, 2024.
  ista: Koval I, Kwan MA. 2024. Exponentially many graphs are determined by their
    spectrum. Quarterly Journal of Mathematics. 75(3), 869–899.
  mla: Koval, Illya, and Matthew Alan Kwan. “Exponentially Many Graphs Are Determined
    by Their Spectrum.” <i>Quarterly Journal of Mathematics</i>, vol. 75, no. 3, Oxford
    University Press, 2024, pp. 869–99, doi:<a href="https://doi.org/10.1093/qmath/haae030">10.1093/qmath/haae030</a>.
  short: I. Koval, M.A. Kwan, Quarterly Journal of Mathematics 75 (2024) 869–899.
corr_author: '1'
das_tickbox: '0'
date_created: 2024-09-01T22:01:07Z
date_published: 2024-06-19T00:00:00Z
date_updated: 2026-10-16T10:14:59Z
day: '19'
ddc:
- '500'
department:
- _id: MaKw
- _id: VaKa
doi: 10.1093/qmath/haae030
external_id:
  arxiv:
  - '2309.09788'
  isi:
  - '001249741500001'
file:
- access_level: open_access
  checksum: abf200d37ad69e6f2c0750a30296ad97
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  creator: cchlebak
  date_created: 2024-09-06T12:23:57Z
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  file_id: '17851'
  file_name: 2024_QuJofMath_Koval.pdf
  file_size: 946411
  relation: main_file
  success: 1
file_date_updated: 2024-09-06T12:23:57Z
fulldoi: https://doi.org/10.1093/qmath/haae030
has_accepted_license: '1'
intvolume: '        75'
isi: 1
issue: '3'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 869-899
project:
- _id: bd95085b-d553-11ed-ba76-e55d3349be45
  grant_number: '101076777'
  name: Randomness and structure in combinatorics
publication: Quarterly Journal of Mathematics
publication_identifier:
  eissn:
  - 1464-3847
  issn:
  - 0033-5606
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Exponentially many graphs are determined by their spectrum
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 75
year: '2024'
...
---
_id: '15118'
abstract:
- lang: eng
  text: Cell division in all domains of life requires the orchestration of many proteins,
    but in Archaea most of the machinery remains poorly characterized. Here we investigate
    the FtsZ-based cell division mechanism in Haloferax volcanii and find proteins
    containing photosynthetic reaction centre (PRC) barrel domains that play an essential
    role in archaeal cell division. We rename these proteins cell division protein
    B 1 (CdpB1) and CdpB2. Depletions and deletions in their respective genes cause
    severe cell division defects, generating drastically enlarged cells. Fluorescence
    microscopy of tagged FtsZ1, FtsZ2 and SepF in CdpB1 and CdpB2 mutant strains revealed
    an unusually disordered divisome that is not organized into a distinct ring-like
    structure. Biochemical analysis shows that SepF forms a tripartite complex with
    CdpB1/2 and crystal structures suggest that these two proteins might form filaments,
    possibly aligning SepF and the FtsZ2 ring during cell division. Overall our results
    indicate that PRC-domain proteins play essential roles in FtsZ-based cell division
    in Archaea.
acknowledged_ssus:
- _id: LifeSc
acknowledgement: We thank X. Ye (ISTA) for providing the His–SUMO expression plasmid
  pSVA13429. pCDB302 was a gift from C. Bahl (Addgene plasmid number 113673; http://n2t.net/addgene:113673;
  RRID Addgene_113673). We thank B. Ahsan, G. Sharov, G. Cannone and S. Chen from
  the Medical Research Council (MRC) LMB Electron Microscopy Facility for help and
  support. We thank Scientific Computing at the MRC LMB for their support. We thank
  L. Trübestein and N. Krasnici of the protein service unit of the ISTA Lab Support
  Facility for help with the SEC coupled with multi-angle light scattering experiments.
  We thank D. Grohmann and R. Reichelt from the Archaea Centre at the University of
  Regensburg for providing the P. furiosus cell material. P.N. and S.-V.A. were supported
  by a Momentum grant from the Volkswagen (VW) Foundation (grant number 94933). D.K.-C.
  and D.B. were supported by the VW Stiftung ‘Life?’ programme (to J.L.; grant number
  Az 96727) and by the MRC, as part of UK Research and Innovation (UKRI), MRC file
  reference number U105184326 (to J.L.). N.T. and S.G. acknowledge support from the
  French Government’s Investissement d’Avenir program, Laboratoire d’Excellence ‘Integrative
  Biology of Emerging Infectious Diseases’ (grant number ANR-10-LABX-62-IBEID), and
  the computational and storage services (Maestro cluster) provided by the IT department
  at Institut Pasteur. M.K. and M.L. were supported by the Austrian Science Fund (FWF)
  Stand-Alone P34607. For the purpose of open access, the MRC Laboratory of Molecular
  Biology has applied a CC BY public copyright licence to any author accepted manuscript
  version arising.
article_processing_charge: No
article_type: original
author:
- first_name: Phillip
  full_name: Nußbaum, Phillip
  last_name: Nußbaum
- first_name: Danguole
  full_name: Kureisaite-Ciziene, Danguole
  last_name: Kureisaite-Ciziene
- first_name: Dom
  full_name: Bellini, Dom
  last_name: Bellini
- first_name: Chris
  full_name: Van Der Does, Chris
  last_name: Van Der Does
- first_name: Marko
  full_name: Kojic, Marko
  id: 73e7ecd4-dc85-11ea-9058-88a16394b160
  last_name: Kojic
  orcid: 0000-0001-7244-8128
- first_name: Najwa
  full_name: Taib, Najwa
  last_name: Taib
- first_name: Anna
  full_name: Yeates, Anna
  last_name: Yeates
- first_name: Maxime
  full_name: Tourte, Maxime
  last_name: Tourte
- first_name: Simonetta
  full_name: Gribaldo, Simonetta
  last_name: Gribaldo
- first_name: Martin
  full_name: Loose, Martin
  id: 462D4284-F248-11E8-B48F-1D18A9856A87
  last_name: Loose
  orcid: 0000-0001-7309-9724
- first_name: Jan
  full_name: Löwe, Jan
  last_name: Löwe
- first_name: Sonja Verena
  full_name: Albers, Sonja Verena
  last_name: Albers
citation:
  ama: Nußbaum P, Kureisaite-Ciziene D, Bellini D, et al. Proteins containing photosynthetic
    reaction centre domains modulate FtsZ-based archaeal cell division. <i>Nature
    Microbiology</i>. 2024;9(3):698-711. doi:<a href="https://doi.org/10.1038/s41564-024-01600-5">10.1038/s41564-024-01600-5</a>
  apa: Nußbaum, P., Kureisaite-Ciziene, D., Bellini, D., Van Der Does, C., Kojic,
    M., Taib, N., … Albers, S. V. (2024). Proteins containing photosynthetic reaction
    centre domains modulate FtsZ-based archaeal cell division. <i>Nature Microbiology</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41564-024-01600-5">https://doi.org/10.1038/s41564-024-01600-5</a>
  chicago: Nußbaum, Phillip, Danguole Kureisaite-Ciziene, Dom Bellini, Chris Van Der
    Does, Marko Kojic, Najwa Taib, Anna Yeates, et al. “Proteins Containing Photosynthetic
    Reaction Centre Domains Modulate FtsZ-Based Archaeal Cell Division.” <i>Nature
    Microbiology</i>. Springer Nature, 2024. <a href="https://doi.org/10.1038/s41564-024-01600-5">https://doi.org/10.1038/s41564-024-01600-5</a>.
  ieee: P. Nußbaum <i>et al.</i>, “Proteins containing photosynthetic reaction centre
    domains modulate FtsZ-based archaeal cell division,” <i>Nature Microbiology</i>,
    vol. 9, no. 3. Springer Nature, pp. 698–711, 2024.
  ista: Nußbaum P, Kureisaite-Ciziene D, Bellini D, Van Der Does C, Kojic M, Taib
    N, Yeates A, Tourte M, Gribaldo S, Loose M, Löwe J, Albers SV. 2024. Proteins
    containing photosynthetic reaction centre domains modulate FtsZ-based archaeal
    cell division. Nature Microbiology. 9(3), 698–711.
  mla: Nußbaum, Phillip, et al. “Proteins Containing Photosynthetic Reaction Centre
    Domains Modulate FtsZ-Based Archaeal Cell Division.” <i>Nature Microbiology</i>,
    vol. 9, no. 3, Springer Nature, 2024, pp. 698–711, doi:<a href="https://doi.org/10.1038/s41564-024-01600-5">10.1038/s41564-024-01600-5</a>.
  short: P. Nußbaum, D. Kureisaite-Ciziene, D. Bellini, C. Van Der Does, M. Kojic,
    N. Taib, A. Yeates, M. Tourte, S. Gribaldo, M. Loose, J. Löwe, S.V. Albers, Nature
    Microbiology 9 (2024) 698–711.
das_tickbox: '1'
dataavailabilitystatement: The data that support the findings of this study are available
  in the Source Data. Source data are provided with this paper. Coordinates have been
  submitted to the Protein Data Bank (PDB) with accession code 8QZO.
date_created: 2024-03-17T23:00:58Z
date_published: 2024-03-04T00:00:00Z
date_updated: 2026-10-16T10:35:48Z
day: '04'
department:
- _id: MaLo
doi: 10.1038/s41564-024-01600-5
external_id:
  isi:
  - '001183270800021'
  pmid:
  - '38443575'
fulldoi: https://doi.org/10.1038/s41564-024-01600-5
intvolume: '         9'
isi: 1
issue: '3'
language:
- iso: eng
month: '03'
oa_version: None
page: 698-711
pmid: 1
project:
- _id: fc38323b-9c52-11eb-aca3-ff8afb4a011d
  grant_number: P34607
  name: In vitro reconstitution of bacterial cell division
publication: Nature Microbiology
publication_identifier:
  eissn:
  - 2058-5276
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
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    status: public
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Proteins containing photosynthetic reaction centre domains modulate FtsZ-based
  archaeal cell division
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 9
year: '2024'
...
---
OA_place: publisher
OA_type: hybrid
_id: '15330'
abstract:
- lang: eng
  text: Clathrin-mediated endocytosis (CME) is vital for the regulation of plant growth
    and development by controlling plasma membrane protein composition and cargo uptake.
    CME relies on the precise recruitment of regulators for vesicle maturation and
    release. Homologues of components of mammalian vesicle scission are strong candidates
    to be part of the scission machinery in plants, but the precise roles of these
    proteins in this process are not fully understood. Here, we characterised the
    roles of Plant Dynamin-Related Proteins 2 (DRP2s) and SH3-domain containing protein
    2 (SH3P2), the plant homologue to Dynamins’ recruiters, like Endophilin and Amphiphysin,
    in the CME by combining high-resolution imaging of endocytic events in vivo and
    characterisation of the purified proteins in vitro. Although DRP2s and SH3P2 arrive
    similarly late during CME and physically interact, genetic analysis of the sh3p123
    triple-mutant and complementation assays with non-SH3P2-interacting DRP2 variants
    suggests that SH3P2 does not directly recruit DRP2s to the site of endocytosis.
    These observations imply that despite the presence of many well-conserved endocytic
    components, plants have acquired a distinct mechanism for CME.
acknowledged_ssus:
- _id: EM-Fac
- _id: LifeSc
- _id: Bio
acknowledgement: "Nataliia Gnyliukh was partially funded by the European Union’s Horizon
  2020 research and\r\ninnovation program (2018-2020) under the Marie Sklodowska-Curie
  Grant (agreement no.\r\n665385). Taif University Researchers Supporting Project:
  TURSP-HC2022/02. and Austrian\r\nScience Fund (FWF): I 6123-B.We thank Prof. Eileen
  Lafer and Liping Wang for their suggestions regarding the optimisation of protein
  expression and purification. We thank Prof. Sebastian Y. Bednarek for the useful
  comments and constructive criticism of the project. We thank Maciek Adamowski for
  providing genetic material. This research was supported by the Scientific Service
  Units (SSU) of IST-Austria through resources provided by the Electron microscopy
  (EMF), Lab Support Facility (LSF) (particularly Dorota Jaworska) and the Bioimaging
  Facility (BIF)."
article_number: jcs.261720
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Nataliia
  full_name: Gnyliukh, Nataliia
  id: 390C1120-F248-11E8-B48F-1D18A9856A87
  last_name: Gnyliukh
  orcid: 0000-0002-2198-0509
- first_name: Alexander J
  full_name: Johnson, Alexander J
  id: 46A62C3A-F248-11E8-B48F-1D18A9856A87
  last_name: Johnson
  orcid: 0000-0002-2739-8843
- first_name: MK
  full_name: Nagel, MK
  last_name: Nagel
- first_name: Aline
  full_name: Monzer, Aline
  id: 2DB5D88C-D7B3-11E9-B8FD-7907E6697425
  last_name: Monzer
- first_name: David
  full_name: Babic, David
  id: db566d23-f6e0-11ea-865d-e6f270e968e7
  last_name: Babic
- first_name: Annamaria
  full_name: Hlavata, Annamaria
  id: 36062FEC-F248-11E8-B48F-1D18A9856A87
  last_name: Hlavata
- first_name: SS
  full_name: Alotaibi, SS
  last_name: Alotaibi
- first_name: E
  full_name: Isono, E
  last_name: Isono
- first_name: Martin
  full_name: Loose, Martin
  id: 462D4284-F248-11E8-B48F-1D18A9856A87
  last_name: Loose
  orcid: 0000-0001-7309-9724
- first_name: Jiří
  full_name: Friml, Jiří
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
citation:
  ama: Gnyliukh N, Johnson AJ, Nagel M, et al. Role of dynamin-related proteins 2
    and SH3P2 in clathrin-mediated endocytosis in Arabidopsis thaliana. <i>Journal
    of Cell Science</i>. 2024;137(8). doi:<a href="https://doi.org/10.1242/jcs.261720">10.1242/jcs.261720</a>
  apa: Gnyliukh, N., Johnson, A. J., Nagel, M., Monzer, A., Babic, D., Hlavata, A.,
    … Friml, J. (2024). Role of dynamin-related proteins 2 and SH3P2 in clathrin-mediated
    endocytosis in Arabidopsis thaliana. <i>Journal of Cell Science</i>. The Company
    of Biologists. <a href="https://doi.org/10.1242/jcs.261720">https://doi.org/10.1242/jcs.261720</a>
  chicago: Gnyliukh, Nataliia, Alexander J Johnson, MK Nagel, Aline Monzer, David
    Babic, Annamaria Hlavata, SS Alotaibi, E Isono, Martin Loose, and Jiří Friml.
    “Role of Dynamin-Related Proteins 2 and SH3P2 in Clathrin-Mediated Endocytosis
    in Arabidopsis Thaliana.” <i>Journal of Cell Science</i>. The Company of Biologists,
    2024. <a href="https://doi.org/10.1242/jcs.261720">https://doi.org/10.1242/jcs.261720</a>.
  ieee: N. Gnyliukh <i>et al.</i>, “Role of dynamin-related proteins 2 and SH3P2 in
    clathrin-mediated endocytosis in Arabidopsis thaliana,” <i>Journal of Cell Science</i>,
    vol. 137, no. 8. The Company of Biologists, 2024.
  ista: Gnyliukh N, Johnson AJ, Nagel M, Monzer A, Babic D, Hlavata A, Alotaibi S,
    Isono E, Loose M, Friml J. 2024. Role of dynamin-related proteins 2 and SH3P2
    in clathrin-mediated endocytosis in Arabidopsis thaliana. Journal of Cell Science.
    137(8), jcs. 261720.
  mla: Gnyliukh, Nataliia, et al. “Role of Dynamin-Related Proteins 2 and SH3P2 in
    Clathrin-Mediated Endocytosis in Arabidopsis Thaliana.” <i>Journal of Cell Science</i>,
    vol. 137, no. 8, jcs. 261720, The Company of Biologists, 2024, doi:<a href="https://doi.org/10.1242/jcs.261720">10.1242/jcs.261720</a>.
  short: N. Gnyliukh, A.J. Johnson, M. Nagel, A. Monzer, D. Babic, A. Hlavata, S.
    Alotaibi, E. Isono, M. Loose, J. Friml, Journal of Cell Science 137 (2024).
corr_author: '1'
das_tickbox: '0'
date_created: 2024-04-19T09:54:59Z
date_published: 2024-04-01T00:00:00Z
date_updated: 2026-10-16T10:38:13Z
day: '01'
ddc:
- '570'
department:
- _id: MaLo
- _id: JiFr
- _id: CaBe
doi: 10.1242/jcs.261720
ec_funded: 1
external_id:
  isi:
  - '001266917100005'
  pmid:
  - '38506228'
file:
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  file_size: 25845948
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file_date_updated: 2025-01-09T08:41:16Z
fulldoi: https://doi.org/10.1242/jcs.261720
has_accepted_license: '1'
intvolume: '       137'
isi: 1
issue: '8'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
- _id: bd76d395-d553-11ed-ba76-f678c14f9033
  grant_number: I06123
  name: Peptide receptors for auxin canalization in Arabidopsis
publication: Journal of Cell Science
publication_identifier:
  eissn:
  - 1477-9137
  issn:
  - 0021-9533
publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
related_material:
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  - id: '14591'
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    status: public
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Role of dynamin-related proteins 2 and SH3P2 in clathrin-mediated endocytosis
  in Arabidopsis thaliana
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 137
year: '2024'
...
---
_id: '15172'
abstract:
- lang: eng
  text: 'We propose a novel approach to concentration for non-independent random variables.
    The main idea is to “pretend” that the random variables are independent and pay
    a multiplicative price measuring how far they are from actually being independent.
    This price is encapsulated in the Hellinger integral between the joint and the
    product of the marginals, which is then upper bounded leveraging tensorisation
    properties. Our bounds represent a natural generalisation of concentration inequalities
    in the presence of dependence: we recover exactly the classical bounds (McDiarmid’s
    inequality) when the random variables are independent. Furthermore, in a “large
    deviations” regime, we obtain the same decay in the probability as for the independent
    case, even when the random variables display non-trivial dependencies. To show
    this, we consider a number of applications of interest. First, we provide a bound
    for Markov chains with finite state space. Then, we consider the Simple Symmetric
    Random Walk, which is a non-contracting Markov chain, and a non-Markovian setting
    in which the stochastic process depends on its entire past. To conclude, we propose
    an application to Markov Chain Monte Carlo methods, where our approach leads to
    an improved lower bound on the minimum burn-in period required to reach a certain
    accuracy. In all of these settings, we provide a regime of parameters in which
    our bound fares better than what the state of the art can provide.'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Amedeo Roberto
  full_name: Esposito, Amedeo Roberto
  id: 9583e921-e1ad-11ec-9862-cef099626dc9
  last_name: Esposito
- first_name: Marco
  full_name: Mondelli, Marco
  id: 27EB676C-8706-11E9-9510-7717E6697425
  last_name: Mondelli
  orcid: 0000-0002-3242-7020
citation:
  ama: Esposito AR, Mondelli M. Concentration without independence via information
    measures. <i>IEEE Transactions on Information Theory</i>. 2024;70(6):3823-3839.
    doi:<a href="https://doi.org/10.1109/TIT.2024.3367767">10.1109/TIT.2024.3367767</a>
  apa: Esposito, A. R., &#38; Mondelli, M. (2024). Concentration without independence
    via information measures. <i>IEEE Transactions on Information Theory</i>. IEEE.
    <a href="https://doi.org/10.1109/TIT.2024.3367767">https://doi.org/10.1109/TIT.2024.3367767</a>
  chicago: Esposito, Amedeo Roberto, and Marco Mondelli. “Concentration without Independence
    via Information Measures.” <i>IEEE Transactions on Information Theory</i>. IEEE,
    2024. <a href="https://doi.org/10.1109/TIT.2024.3367767">https://doi.org/10.1109/TIT.2024.3367767</a>.
  ieee: A. R. Esposito and M. Mondelli, “Concentration without independence via information
    measures,” <i>IEEE Transactions on Information Theory</i>, vol. 70, no. 6. IEEE,
    pp. 3823–3839, 2024.
  ista: Esposito AR, Mondelli M. 2024. Concentration without independence via information
    measures. IEEE Transactions on Information Theory. 70(6), 3823–3839.
  mla: Esposito, Amedeo Roberto, and Marco Mondelli. “Concentration without Independence
    via Information Measures.” <i>IEEE Transactions on Information Theory</i>, vol.
    70, no. 6, IEEE, 2024, pp. 3823–39, doi:<a href="https://doi.org/10.1109/TIT.2024.3367767">10.1109/TIT.2024.3367767</a>.
  short: A.R. Esposito, M. Mondelli, IEEE Transactions on Information Theory 70 (2024)
    3823–3839.
corr_author: '1'
das_tickbox: '0'
date_created: 2024-03-24T23:01:00Z
date_published: 2024-06-01T00:00:00Z
date_updated: 2026-10-16T10:39:43Z
day: '01'
department:
- _id: MaMo
doi: 10.1109/TIT.2024.3367767
external_id:
  arxiv:
  - '2303.07245'
  isi:
  - '001230181100001'
fulldoi: https://doi.org/10.1109/TIT.2024.3367767
intvolume: '        70'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2303.07245
month: '06'
oa: 1
oa_version: Preprint
page: 3823-3839
project:
- _id: 059876FA-7A3F-11EA-A408-12923DDC885E
  name: Prix Lopez-Loretta 2019 - Marco Mondelli
publication: IEEE Transactions on Information Theory
publication_identifier:
  eissn:
  - 1557-9654
  issn:
  - 0018-9448
publication_status: published
publisher: IEEE
quality_controlled: '1'
related_material:
  record:
  - id: '14922'
    relation: earlier_version
    status: public
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Concentration without independence via information measures
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 70
year: '2024'
...
---
_id: '17893'
abstract:
- lang: eng
  text: Strong data processing inequalities (SDPI) are an important object of study
    in Information Theory and have been well studied for f -divergences. Universal
    upper and lower bounds have been provided along with several applications, connecting
    them to impossibility (converse) results, concentration of measure, hypercontractivity,
    and so on. In this paper, we study Renyi divergence and the corresponding SDPI
    constant whose behavior seems to deviate from that of ordinary <1>-divergences.
    In particular, one can find examples showing that the universal upper bound relating
    its SDPI constant to the one of Total Variation does not hold in general. In this
    work, we prove, however, that the universal lower bound involving the SDPI constant
    of the Chi-square divergence does indeed hold. Furthermore, we also provide a
    characterization of the distribution that achieves the supremum when is equal
    to 2 and consequently compute the SDPI constant for Renyi divergence of the general
    binary channel.
acknowledgement: "The work in this paper was supported in part by the Swiss National
  Science Foundation under Grant 200364.\r\n"
article_processing_charge: No
arxiv: 1
author:
- first_name: Lifu
  full_name: Jin, Lifu
  last_name: Jin
- first_name: Amedeo Roberto
  full_name: Esposito, Amedeo Roberto
  id: 9583e921-e1ad-11ec-9862-cef099626dc9
  last_name: Esposito
- first_name: Michael
  full_name: Gastpar, Michael
  last_name: Gastpar
citation:
  ama: 'Jin L, Esposito AR, Gastpar M. Properties of the strong data processing constant
    for Rényi divergence. In: <i>Proceedings of the 2024 IEEE International Symposium
    on Information Theory</i>. IEEE; 2024:3178-3183. doi:<a href="https://doi.org/10.1109/ISIT57864.2024.10619367">10.1109/ISIT57864.2024.10619367</a>'
  apa: 'Jin, L., Esposito, A. R., &#38; Gastpar, M. (2024). Properties of the strong
    data processing constant for Rényi divergence. In <i>Proceedings of the 2024 IEEE
    International Symposium on Information Theory</i> (pp. 3178–3183). Athens, Greece:
    IEEE. <a href="https://doi.org/10.1109/ISIT57864.2024.10619367">https://doi.org/10.1109/ISIT57864.2024.10619367</a>'
  chicago: Jin, Lifu, Amedeo Roberto Esposito, and Michael Gastpar. “Properties of
    the Strong Data Processing Constant for Rényi Divergence.” In <i>Proceedings of
    the 2024 IEEE International Symposium on Information Theory</i>, 3178–83. IEEE,
    2024. <a href="https://doi.org/10.1109/ISIT57864.2024.10619367">https://doi.org/10.1109/ISIT57864.2024.10619367</a>.
  ieee: L. Jin, A. R. Esposito, and M. Gastpar, “Properties of the strong data processing
    constant for Rényi divergence,” in <i>Proceedings of the 2024 IEEE International
    Symposium on Information Theory</i>, Athens, Greece, 2024, pp. 3178–3183.
  ista: 'Jin L, Esposito AR, Gastpar M. 2024. Properties of the strong data processing
    constant for Rényi divergence. Proceedings of the 2024 IEEE International Symposium
    on Information Theory. ISIT: International Symposium on Information Theory, 3178–3183.'
  mla: Jin, Lifu, et al. “Properties of the Strong Data Processing Constant for Rényi
    Divergence.” <i>Proceedings of the 2024 IEEE International Symposium on Information
    Theory</i>, IEEE, 2024, pp. 3178–83, doi:<a href="https://doi.org/10.1109/ISIT57864.2024.10619367">10.1109/ISIT57864.2024.10619367</a>.
  short: L. Jin, A.R. Esposito, M. Gastpar, in:, Proceedings of the 2024 IEEE International
    Symposium on Information Theory, IEEE, 2024, pp. 3178–3183.
conference:
  end_date: 2024-07-12
  location: Athens, Greece
  name: 'ISIT: International Symposium on Information Theory'
  start_date: 2024-07-07
corr_author: '1'
das_tickbox: '0'
date_created: 2024-09-08T22:01:12Z
date_published: 2024-08-19T00:00:00Z
date_updated: 2026-10-16T10:38:29Z
day: '19'
department:
- _id: MaMo
doi: 10.1109/ISIT57864.2024.10619367
external_id:
  arxiv:
  - '2403.10656'
  isi:
  - '001304426903055'
fulldoi: https://doi.org/10.1109/ISIT57864.2024.10619367
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: 'https://doi.org/10.48550/arXiv.2403.10656 '
month: '08'
oa: 1
oa_version: Preprint
page: 3178-3183
publication: Proceedings of the 2024 IEEE International Symposium on Information Theory
publication_identifier:
  isbn:
  - '9798350382846'
  issn:
  - 2157-8095
publication_status: published
publisher: IEEE
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Properties of the strong data processing constant for Rényi divergence
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
year: '2024'
...
---
_id: '14665'
abstract:
- lang: eng
  text: We derive lower bounds on the maximal rates for multiple packings in high-dimensional
    Euclidean spaces. For any N > 0 and L ∈ Z ≥2 , a multiple packing is a set C of
    points in R n such that any point in R n lies in the intersection of at most L
    - 1 balls of radius √ nN around points in C . This is a natural generalization
    of the sphere packing problem. We study the multiple packing problem for both
    bounded point sets whose points have norm at most √ nP for some constant P > 0,
    and unbounded point sets whose points are allowed to be anywhere in R n . Given
    a well-known connection with coding theory, multiple packings can be viewed as
    the Euclidean analog of list-decodable codes, which are well-studied over finite
    fields. We derive the best known lower bounds on the optimal multiple packing
    density. This is accomplished by establishing an inequality which relates the
    list-decoding error exponent for additive white Gaussian noise channels, a quantity
    of average-case nature, to the list-decoding radius, a quantity of worst-case
    nature. We also derive novel bounds on the list-decoding error exponent for infinite
    constellations and closed-form expressions for the list-decoding error exponents
    for the power-constrained AWGN channel, which may be of independent interest beyond
    multiple packing.
acknowledgement: "The work of Yihan Zhang was supported by the European Union’s Horizon
  2020 Research and Innovation Programme under Grant 682203-ERC-[Inf-Speed-Tradeoff].
  The work of Shashank Vatedka was supported in part by the Core Research Grant from
  the Science and\r\nEngineering Research Board, India, under Grant CRG/2022/004464;
  and in\r\npart by the Department of Science and Technology (DST), India, under Grant\r\nDST/INT/RUS/RSF/P-41/2020
  (TPN No. 65025)."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Yihan
  full_name: Zhang, Yihan
  id: 2ce5da42-b2ea-11eb-bba5-9f264e9d002c
  last_name: Zhang
  orcid: 0000-0002-6465-6258
- first_name: Shashank
  full_name: Vatedka, Shashank
  last_name: Vatedka
citation:
  ama: 'Zhang Y, Vatedka S. Multiple packing: Lower bounds via error exponents. <i>IEEE
    Transactions on Information Theory</i>. 2024;70(2):1008-1039. doi:<a href="https://doi.org/10.1109/TIT.2023.3334032">10.1109/TIT.2023.3334032</a>'
  apa: 'Zhang, Y., &#38; Vatedka, S. (2024). Multiple packing: Lower bounds via error
    exponents. <i>IEEE Transactions on Information Theory</i>. IEEE. <a href="https://doi.org/10.1109/TIT.2023.3334032">https://doi.org/10.1109/TIT.2023.3334032</a>'
  chicago: 'Zhang, Yihan, and Shashank Vatedka. “Multiple Packing: Lower Bounds via
    Error Exponents.” <i>IEEE Transactions on Information Theory</i>. IEEE, 2024.
    <a href="https://doi.org/10.1109/TIT.2023.3334032">https://doi.org/10.1109/TIT.2023.3334032</a>.'
  ieee: 'Y. Zhang and S. Vatedka, “Multiple packing: Lower bounds via error exponents,”
    <i>IEEE Transactions on Information Theory</i>, vol. 70, no. 2. IEEE, pp. 1008–1039,
    2024.'
  ista: 'Zhang Y, Vatedka S. 2024. Multiple packing: Lower bounds via error exponents.
    IEEE Transactions on Information Theory. 70(2), 1008–1039.'
  mla: 'Zhang, Yihan, and Shashank Vatedka. “Multiple Packing: Lower Bounds via Error
    Exponents.” <i>IEEE Transactions on Information Theory</i>, vol. 70, no. 2, IEEE,
    2024, pp. 1008–39, doi:<a href="https://doi.org/10.1109/TIT.2023.3334032">10.1109/TIT.2023.3334032</a>.'
  short: Y. Zhang, S. Vatedka, IEEE Transactions on Information Theory 70 (2024) 1008–1039.
corr_author: '1'
das_tickbox: '0'
date_created: 2023-12-10T23:01:00Z
date_published: 2024-02-01T00:00:00Z
date_updated: 2026-10-16T10:39:20Z
day: '01'
department:
- _id: MaMo
doi: 10.1109/TIT.2023.3334032
external_id:
  arxiv:
  - '2211.04408'
  isi:
  - '001166812100008'
fulldoi: https://doi.org/10.1109/TIT.2023.3334032
intvolume: '        70'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2211.04408
month: '02'
oa: 1
oa_version: Preprint
page: 1008-1039
publication: IEEE Transactions on Information Theory
publication_identifier:
  eissn:
  - 1557-9654
  issn:
  - 0018-9448
publication_status: published
publisher: IEEE
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: 'Multiple packing: Lower bounds via error exponents'
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 70
year: '2024'
...
---
_id: '17895'
abstract:
- lang: eng
  text: We propose a concatenated code construction for a class of discrete-alphabet
    oblivious arbitrarily varying channels (AVCs) with cost constraints. The code
    has time and space complexity polynomial in the blocklength n . It uses a Reed-Solomon
    outer code, logarithmic blocklength random inner codes, and stochastic encoding
    by permuting the codeword before transmission. When the channel satisfies a condition
    called strong DS-nonsymmetrizability (a modified version of nonsymmetrizability
    originally due to Dobrushin and Stambler), we show that the code achieves a rate
    that for a variety of oblivious AVCs (such as classically studied error/erasure
    channels) match the known capacities.
acknowledgement: "The work of M. Langberg and A. D. Sarwate was supported in part
  by the US NSF under awards CCF-1909451 and CCF1909468. B. K. Dey was supported in
  part by the Bharti Centre\r\nfor Communication in IIT Bombay. "
article_processing_charge: No
author:
- first_name: B. K.
  full_name: Dey, B. K.
  last_name: Dey
- first_name: S.
  full_name: Jaggi, S.
  last_name: Jaggi
- first_name: M.
  full_name: Langberg, M.
  last_name: Langberg
- first_name: A. D.
  full_name: Sarwate, A. D.
  last_name: Sarwate
- first_name: Yihan
  full_name: Zhang, Yihan
  id: 2ce5da42-b2ea-11eb-bba5-9f264e9d002c
  last_name: Zhang
  orcid: 0000-0002-6465-6258
citation:
  ama: 'Dey BK, Jaggi S, Langberg M, Sarwate AD, Zhang Y. Computationally efficient
    codes for strongly Dobrushin-Stambler nonsymmetrizable oblivious AVCs. In: <i>Proceedings
    of the 2024 IEEE International Symposium on Information Theory </i>. IEEE; 2024:1586-1591.
    doi:<a href="https://doi.org/10.1109/ISIT57864.2024.10619362">10.1109/ISIT57864.2024.10619362</a>'
  apa: 'Dey, B. K., Jaggi, S., Langberg, M., Sarwate, A. D., &#38; Zhang, Y. (2024).
    Computationally efficient codes for strongly Dobrushin-Stambler nonsymmetrizable
    oblivious AVCs. In <i>Proceedings of the 2024 IEEE International Symposium on
    Information Theory </i> (pp. 1586–1591). Athens, Greece: IEEE. <a href="https://doi.org/10.1109/ISIT57864.2024.10619362">https://doi.org/10.1109/ISIT57864.2024.10619362</a>'
  chicago: Dey, B. K., S. Jaggi, M. Langberg, A. D. Sarwate, and Yihan Zhang. “Computationally
    Efficient Codes for Strongly Dobrushin-Stambler Nonsymmetrizable Oblivious AVCs.”
    In <i>Proceedings of the 2024 IEEE International Symposium on Information Theory
    </i>, 1586–91. IEEE, 2024. <a href="https://doi.org/10.1109/ISIT57864.2024.10619362">https://doi.org/10.1109/ISIT57864.2024.10619362</a>.
  ieee: B. K. Dey, S. Jaggi, M. Langberg, A. D. Sarwate, and Y. Zhang, “Computationally
    efficient codes for strongly Dobrushin-Stambler nonsymmetrizable oblivious AVCs,”
    in <i>Proceedings of the 2024 IEEE International Symposium on Information Theory
    </i>, Athens, Greece, 2024, pp. 1586–1591.
  ista: 'Dey BK, Jaggi S, Langberg M, Sarwate AD, Zhang Y. 2024. Computationally efficient
    codes for strongly Dobrushin-Stambler nonsymmetrizable oblivious AVCs. Proceedings
    of the 2024 IEEE International Symposium on Information Theory . ISIT: International
    Symposium on Information Theory, 1586–1591.'
  mla: Dey, B. K., et al. “Computationally Efficient Codes for Strongly Dobrushin-Stambler
    Nonsymmetrizable Oblivious AVCs.” <i>Proceedings of the 2024 IEEE International
    Symposium on Information Theory </i>, IEEE, 2024, pp. 1586–91, doi:<a href="https://doi.org/10.1109/ISIT57864.2024.10619362">10.1109/ISIT57864.2024.10619362</a>.
  short: B.K. Dey, S. Jaggi, M. Langberg, A.D. Sarwate, Y. Zhang, in:, Proceedings
    of the 2024 IEEE International Symposium on Information Theory , IEEE, 2024, pp.
    1586–1591.
conference:
  end_date: 2024-07-12
  location: Athens, Greece
  name: 'ISIT: International Symposium on Information Theory'
  start_date: 2024-07-07
das_tickbox: '0'
date_created: 2024-09-08T22:01:12Z
date_published: 2024-08-19T00:00:00Z
date_updated: 2026-10-16T10:39:03Z
day: '19'
department:
- _id: MaMo
doi: 10.1109/ISIT57864.2024.10619362
external_id:
  isi:
  - '001304426901091'
fulldoi: https://doi.org/10.1109/ISIT57864.2024.10619362
isi: 1
language:
- iso: eng
month: '08'
oa_version: None
page: 1586-1591
publication: 'Proceedings of the 2024 IEEE International Symposium on Information
  Theory '
publication_identifier:
  isbn:
  - '9798350382846'
  issn:
  - 2157-8095
publication_status: published
publisher: IEEE
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Computationally efficient codes for strongly Dobrushin-Stambler nonsymmetrizable
  oblivious AVCs
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
year: '2024'
...
---
_id: '17894'
abstract:
- lang: eng
  text: 'Sibson''s α -mutual information has received renewed attention recently in
    several contexts: concentration of measure under dependence, statistical learning,
    hypothesis testing, and estimation theory. In this work, we introduce several
    variational representations of Sibson''s α -mutual information: 1) as a supremum
    over joint distributions of (a combination of) KL divergences; and 2) as a supremum
    over functions of opportune expected values. Leveraging them, we produce a variety
    of novel and known results, including a generalization of transportation-cost
    inequalities and Fano''s inequality.'
acknowledgement: The work in this paper was supported in part by the Swiss National
  Science Foundation under Grant 200364.
article_processing_charge: No
author:
- first_name: Amedeo Roberto
  full_name: Esposito, Amedeo Roberto
  id: 9583e921-e1ad-11ec-9862-cef099626dc9
  last_name: Esposito
- first_name: Michael
  full_name: Gastpar, Michael
  last_name: Gastpar
- first_name: Ibrahim
  full_name: Issa, Ibrahim
  last_name: Issa
citation:
  ama: 'Esposito AR, Gastpar M, Issa I. Variational characterizations of Sibson’s
    α-mutual information. In: <i>Proceedings of the 2024 IEEE International Symposium
    on Information Theory </i>. IEEE; 2024:2110-2115. doi:<a href="https://doi.org/10.1109/ISIT57864.2024.10619378">10.1109/ISIT57864.2024.10619378</a>'
  apa: 'Esposito, A. R., Gastpar, M., &#38; Issa, I. (2024). Variational characterizations
    of Sibson’s α-mutual information. In <i>Proceedings of the 2024 IEEE International
    Symposium on Information Theory </i> (pp. 2110–2115). Athens, Greece: IEEE. <a
    href="https://doi.org/10.1109/ISIT57864.2024.10619378">https://doi.org/10.1109/ISIT57864.2024.10619378</a>'
  chicago: Esposito, Amedeo Roberto, Michael Gastpar, and Ibrahim Issa. “Variational
    Characterizations of Sibson’s α-Mutual Information.” In <i>Proceedings of the
    2024 IEEE International Symposium on Information Theory </i>, 2110–15. IEEE, 2024.
    <a href="https://doi.org/10.1109/ISIT57864.2024.10619378">https://doi.org/10.1109/ISIT57864.2024.10619378</a>.
  ieee: A. R. Esposito, M. Gastpar, and I. Issa, “Variational characterizations of
    Sibson’s α-mutual information,” in <i>Proceedings of the 2024 IEEE International
    Symposium on Information Theory </i>, Athens, Greece, 2024, pp. 2110–2115.
  ista: 'Esposito AR, Gastpar M, Issa I. 2024. Variational characterizations of Sibson’s
    α-mutual information. Proceedings of the 2024 IEEE International Symposium on
    Information Theory . ISIT: International Symposium on Information Theory, 2110–2115.'
  mla: Esposito, Amedeo Roberto, et al. “Variational Characterizations of Sibson’s
    α-Mutual Information.” <i>Proceedings of the 2024 IEEE International Symposium
    on Information Theory </i>, IEEE, 2024, pp. 2110–15, doi:<a href="https://doi.org/10.1109/ISIT57864.2024.10619378">10.1109/ISIT57864.2024.10619378</a>.
  short: A.R. Esposito, M. Gastpar, I. Issa, in:, Proceedings of the 2024 IEEE International
    Symposium on Information Theory , IEEE, 2024, pp. 2110–2115.
conference:
  end_date: 2024-07-12
  location: Athens, Greece
  name: 'ISIT: International Symposium on Information Theory'
  start_date: 2024-07-07
corr_author: '1'
das_tickbox: '0'
date_created: 2024-09-08T22:01:12Z
date_published: 2024-08-19T00:00:00Z
date_updated: 2026-10-16T10:38:46Z
day: '19'
department:
- _id: MaMo
doi: 10.1109/ISIT57864.2024.10619378
external_id:
  isi:
  - '001304426902023'
fulldoi: https://doi.org/10.1109/ISIT57864.2024.10619378
isi: 1
language:
- iso: eng
month: '08'
oa_version: None
page: 2110-2115
publication: 'Proceedings of the 2024 IEEE International Symposium on Information
  Theory '
publication_identifier:
  isbn:
  - '9798350382846'
  issn:
  - 2157-8095
publication_status: published
publisher: IEEE
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Variational characterizations of Sibson's α-mutual information
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
year: '2024'
...
---
_id: '14932'
abstract:
- lang: eng
  text: The huge antlers of the extinct Irish elk have invited evolutionary speculation
    since Darwin. In the 1970s, Stephen Jay Gould presented the first extensive data
    on antler size in the Irish elk and combined these with comparative data from
    other deer to test the hypothesis that the gigantic antlers were the outcome of
    a positive allometry that constrained large-bodied deer to have proportionally
    even larger antlers. He concluded that the Irish elk had antlers as predicted
    for its size and interpreted this within his emerging framework of developmental
    constraints as an explanatory factor in evolution. Here we reanalyze antler allometry
    based on new morphometric data for 57 taxa of the family Cervidae. We also present
    a new phylogeny for the Cervidae, which we use for comparative analyses. In contrast
    to Gould, we find that the antlers of Irish elk were larger than predicted from
    the allometry within the true deer, Cervini, as analyzed by Gould, but follow
    the allometry across Cervidae as a whole. After dissecting the discrepancy, we
    reject the allometric-constraint hypothesis because, contrary to Gould, we find
    no similarity between static and evolutionary allometries, and because we document
    extensive non-allometric evolution of antler size across the Cervidae.
acknowledgement: "Open access funding provided by University of Oslo (incl Oslo University
  Hospital).\r\nWe thank Adrian Lister, Louis Tomsett, Roberto Portela Miguez and
  Roula Pappa (NHMUK), Brian O'Toole and Eileen Westwig (AMNH), Daniela Kalthoff (NHRM),
  Alexander Bibl and Zachos Frank (NHMW), Darrin Lunde and John Ososky (NMNH), Matthew
  Parkes and Nigel Monaghan (NMI), Elizabetta Cioppi and Luca Bellucci (IGF), and
  Yoshihiro Tanaka and Hiroyuki Taruno (OMNH), who helped us in obtaining the museum
  data, and a special thanks to Jørgen Sikkeland (NTNU NHM) for assistance in obtaining
  the ontogenetic data for the red deer. We thank Olja Toljagic and Kjetil L. Voje
  for discussions, Ayumu Tsuboi for assistance with data collection, and Jean-Michel
  Gaillard and the anonymous reviewers for comments on the manuscript. We thank the
  Centre of Advanced Study (CAS) at the Norwegian Academy of Sciences and Letters
  for hosting us during the academic year of 2019/2020 when much of the analysis and
  writing were done. MT was funded by JSPS Research Fellowship for Young Scientists
  (201603238)."
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Masahito
  full_name: Tsuboi, Masahito
  last_name: Tsuboi
- first_name: Bjørn Tore
  full_name: Kopperud, Bjørn Tore
  last_name: Kopperud
- first_name: Michael
  full_name: Matschiner, Michael
  last_name: Matschiner
- first_name: Mark
  full_name: Grabowski, Mark
  last_name: Grabowski
- first_name: Chrsitine
  full_name: Syrowatka, Chrsitine
  id: 205ffb76-7fe7-11eb-aa17-958bd11b99ad
  last_name: Syrowatka
- first_name: Christophe
  full_name: Pélabon, Christophe
  last_name: Pélabon
- first_name: Thomas F.
  full_name: Hansen, Thomas F.
  last_name: Hansen
citation:
  ama: Tsuboi M, Kopperud BT, Matschiner M, et al. Antler allometry, the Irish elk
    and Gould revisited. <i>Evolutionary Biology</i>. 2024;51:149-165. doi:<a href="https://doi.org/10.1007/s11692-023-09624-1">10.1007/s11692-023-09624-1</a>
  apa: Tsuboi, M., Kopperud, B. T., Matschiner, M., Grabowski, M., Syrowatka, C.,
    Pélabon, C., &#38; Hansen, T. F. (2024). Antler allometry, the Irish elk and Gould
    revisited. <i>Evolutionary Biology</i>. Springer Nature. <a href="https://doi.org/10.1007/s11692-023-09624-1">https://doi.org/10.1007/s11692-023-09624-1</a>
  chicago: Tsuboi, Masahito, Bjørn Tore Kopperud, Michael Matschiner, Mark Grabowski,
    Chrsitine Syrowatka, Christophe Pélabon, and Thomas F. Hansen. “Antler Allometry,
    the Irish Elk and Gould Revisited.” <i>Evolutionary Biology</i>. Springer Nature,
    2024. <a href="https://doi.org/10.1007/s11692-023-09624-1">https://doi.org/10.1007/s11692-023-09624-1</a>.
  ieee: M. Tsuboi <i>et al.</i>, “Antler allometry, the Irish elk and Gould revisited,”
    <i>Evolutionary Biology</i>, vol. 51. Springer Nature, pp. 149–165, 2024.
  ista: Tsuboi M, Kopperud BT, Matschiner M, Grabowski M, Syrowatka C, Pélabon C,
    Hansen TF. 2024. Antler allometry, the Irish elk and Gould revisited. Evolutionary
    Biology. 51, 149–165.
  mla: Tsuboi, Masahito, et al. “Antler Allometry, the Irish Elk and Gould Revisited.”
    <i>Evolutionary Biology</i>, vol. 51, Springer Nature, 2024, pp. 149–65, doi:<a
    href="https://doi.org/10.1007/s11692-023-09624-1">10.1007/s11692-023-09624-1</a>.
  short: M. Tsuboi, B.T. Kopperud, M. Matschiner, M. Grabowski, C. Syrowatka, C. Pélabon,
    T.F. Hansen, Evolutionary Biology 51 (2024) 149–165.
das_tickbox: '1'
dataavailabilitystatement: All data used in this paper are available from the authors
  on request.
date_created: 2024-02-04T23:00:53Z
date_published: 2024-03-01T00:00:00Z
date_updated: 2026-10-16T10:43:26Z
day: '01'
ddc:
- '570'
department:
- _id: MaRo
doi: 10.1007/s11692-023-09624-1
external_id:
  isi:
  - '001151285200001'
file:
- access_level: open_access
  checksum: 416ab4dac751c443b9de51fb58278ff2
  content_type: application/pdf
  creator: dernst
  date_created: 2024-07-22T11:53:43Z
  date_updated: 2024-07-22T11:53:43Z
  file_id: '17311'
  file_name: 2024_EvolutionaryBio_Tsuboi.pdf
  file_size: 1705974
  relation: main_file
  success: 1
file_date_updated: 2024-07-22T11:53:43Z
fulldoi: https://doi.org/10.1007/s11692-023-09624-1
has_accepted_license: '1'
intvolume: '        51'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 149-165
publication: Evolutionary Biology
publication_identifier:
  eissn:
  - 1934-2845
  issn:
  - 0071-3260
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: upon request
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Antler allometry, the Irish elk and Gould revisited
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 51
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '17147'
abstract:
- lang: eng
  text: Efficient utilization of large-scale biobank data is crucial for inferring
    the genetic basis of disease and predicting health outcomes from the DNA. Yet
    we lack efficient, accurate methods that scale to data where electronic health
    records are linked to whole genome sequence information. To address this issue,
    our paper develops a new algorithmic paradigm based on Approximate Message Passing
    (AMP), which is specifically tailored for genomic prediction and association testing.
    Our method yields comparable out-of-sample prediction accuracy to the state of
    the art on UK Biobank traits, whilst dramatically improving computational complexity,
    with a 8x-speed up in the run time. In addition, AMP theory provides a joint association
    testing framework, which outperforms the currently used REGENIE method, in roughly
    a third of the compute time. This first, truly large-scale application of the
    AMP framework lays the foundations for a far wider range of statistical analyses
    for hundreds of millions of variables measured on millions of people.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: "This work was supported by a Lopez-Loreta Prize to MM, an SNSF Eccellenza
  Grant to MRR (PCEGP3-181181), and core funding from ISTA. The authors thank Philip
  Schniter, Matthew Stephens and Pragya Sur for valuable suggestions on an early version
  of the work. The authors acknowledge the participants and investigators of the UK
  Biobank study. High-performance\r\ncomputing was supported by the Scientific Service
  Units (SSU) of IST Austria through resources provided by Scientific Computing (SciComp)."
article_processing_charge: No
author:
- first_name: Al
  full_name: Depope, Al
  id: 0b77531d-dbcd-11ea-9d1d-a8eee0bf3830
  last_name: Depope
- first_name: Marco
  full_name: Mondelli, Marco
  id: 27EB676C-8706-11E9-9510-7717E6697425
  last_name: Mondelli
  orcid: 0000-0002-3242-7020
- first_name: Matthew Richard
  full_name: Robinson, Matthew Richard
  id: E5D42276-F5DA-11E9-8E24-6303E6697425
  last_name: Robinson
  orcid: 0000-0001-8982-8813
citation:
  ama: 'Depope A, Mondelli M, Robinson MR. Inference of genetic effects via approximate
    message passing. In: <i>2024 IEEE International Conference on Acoustics, Speech,
    and Signal Processing</i>. IEEE; 2024:13151-13155. doi:<a href="https://doi.org/10.1109/ICASSP48485.2024.10447198">10.1109/ICASSP48485.2024.10447198</a>'
  apa: 'Depope, A., Mondelli, M., &#38; Robinson, M. R. (2024). Inference of genetic
    effects via approximate message passing. In <i>2024 IEEE International Conference
    on Acoustics, Speech, and Signal Processing</i> (pp. 13151–13155). Seoul, Korea:
    IEEE. <a href="https://doi.org/10.1109/ICASSP48485.2024.10447198">https://doi.org/10.1109/ICASSP48485.2024.10447198</a>'
  chicago: Depope, Al, Marco Mondelli, and Matthew Richard Robinson. “Inference of
    Genetic Effects via Approximate Message Passing.” In <i>2024 IEEE International
    Conference on Acoustics, Speech, and Signal Processing</i>, 13151–55. IEEE, 2024.
    <a href="https://doi.org/10.1109/ICASSP48485.2024.10447198">https://doi.org/10.1109/ICASSP48485.2024.10447198</a>.
  ieee: A. Depope, M. Mondelli, and M. R. Robinson, “Inference of genetic effects
    via approximate message passing,” in <i>2024 IEEE International Conference on
    Acoustics, Speech, and Signal Processing</i>, Seoul, Korea, 2024, pp. 13151–13155.
  ista: 'Depope A, Mondelli M, Robinson MR. 2024. Inference of genetic effects via
    approximate message passing. 2024 IEEE International Conference on Acoustics,
    Speech, and Signal Processing. ICASSP: International Conference on Acoustics,
    Speech and Signal Processing, 13151–13155.'
  mla: Depope, Al, et al. “Inference of Genetic Effects via Approximate Message Passing.”
    <i>2024 IEEE International Conference on Acoustics, Speech, and Signal Processing</i>,
    IEEE, 2024, pp. 13151–55, doi:<a href="https://doi.org/10.1109/ICASSP48485.2024.10447198">10.1109/ICASSP48485.2024.10447198</a>.
  short: A. Depope, M. Mondelli, M.R. Robinson, in:, 2024 IEEE International Conference
    on Acoustics, Speech, and Signal Processing, IEEE, 2024, pp. 13151–13155.
conference:
  end_date: 2024-04-19
  location: Seoul, Korea
  name: 'ICASSP: International Conference on Acoustics, Speech and Signal Processing'
  start_date: 2024-04-14
corr_author: '1'
das_tickbox: '0'
date_created: 2024-06-16T22:01:07Z
date_published: 2024-04-19T00:00:00Z
date_updated: 2026-10-16T10:42:55Z
day: '19'
department:
- _id: MaMo
- _id: MaRo
doi: 10.1109/ICASSP48485.2024.10447198
external_id:
  isi:
  - '001396233806078'
fulldoi: https://doi.org/10.1109/ICASSP48485.2024.10447198
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://openreview.net/forum?id=aQYCDxfZV0
month: '04'
oa: 1
oa_version: Submitted Version
page: 13151-13155
project:
- _id: 059876FA-7A3F-11EA-A408-12923DDC885E
  name: Prix Lopez-Loretta 2019 - Marco Mondelli
- _id: 9B8D11D6-BA93-11EA-9121-9846C619BF3A
  grant_number: PCEGP3_181181
  name: Improving estimation and prediction of common complex disease risk
publication: 2024 IEEE International Conference on Acoustics, Speech, and Signal Processing
publication_identifier:
  isbn:
  - '9798350344851'
  issn:
  - 1520-6149
publication_status: published
publisher: IEEE
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Inference of genetic effects via approximate message passing
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '18973'
abstract:
- lang: eng
  text: 'Understanding the reasons behind the exceptional success of transformers
    requires a better analysis of why attention layers are suitable for NLP tasks.
    In particular, such tasks require predictive models to capture contextual meaning
    which often depends on one or few words, even if the sentence is long. Our work
    studies this key property, dubbed word sensitivity (WS), in the prototypical setting
    of random features. We show that attention layers enjoy high WS, namely, there
    exists a vector in the space of embeddings that largely perturbs the random attention
    features map. The argument critically exploits the role of the softmax in the
    attention layer, highlighting its benefit compared to other activations (e.g.,
    ReLU). In contrast, the WS of standard random features is of order 1/n−−√, n being
    the number of words in the textual sample, and thus it decays with the length
    of the context. We then translate these results on the word sensitivity into generalization
    bounds: due to their low WS, random features provably cannot learn to distinguish
    between two sentences that differ only in a single word; in contrast, due to their
    high WS, random attention features have higher generalization capabilities. We
    validate our theoretical results with experimental evidence over the BERT-Base
    word embeddings of the imdb review dataset.'
acknowledgement: The authors were partially supported by the 2019 LopezLoreta prize,
  and they would like to thank Mohammad Hossein Amani, Lorenzo Beretta, and Clement
  Rebuffel for helpful discussions.
alternative_title:
- PMLR
article_processing_charge: No
arxiv: 1
author:
- first_name: Simone
  full_name: Bombari, Simone
  id: ca726dda-de17-11ea-bc14-f9da834f63aa
  last_name: Bombari
- first_name: Marco
  full_name: Mondelli, Marco
  id: 27EB676C-8706-11E9-9510-7717E6697425
  last_name: Mondelli
  orcid: 0000-0002-3242-7020
citation:
  ama: 'Bombari S, Mondelli M. Towards understanding the word sensitivity of attention
    layers: A study via random features. In: <i>41st International Conference on Machine
    Learning</i>. Vol 235. ML Research Press; 2024:4300-4328.'
  apa: 'Bombari, S., &#38; Mondelli, M. (2024). Towards understanding the word sensitivity
    of attention layers: A study via random features. In <i>41st International Conference
    on Machine Learning</i> (Vol. 235, pp. 4300–4328). Vienna, Austria: ML Research
    Press.'
  chicago: 'Bombari, Simone, and Marco Mondelli. “Towards Understanding the Word Sensitivity
    of Attention Layers: A Study via Random Features.” In <i>41st International Conference
    on Machine Learning</i>, 235:4300–4328. ML Research Press, 2024.'
  ieee: 'S. Bombari and M. Mondelli, “Towards understanding the word sensitivity of
    attention layers: A study via random features,” in <i>41st International Conference
    on Machine Learning</i>, Vienna, Austria, 2024, vol. 235, pp. 4300–4328.'
  ista: 'Bombari S, Mondelli M. 2024. Towards understanding the word sensitivity of
    attention layers: A study via random features. 41st International Conference on
    Machine Learning. ICML: International Conference on Machine Learning, PMLR, vol.
    235, 4300–4328.'
  mla: 'Bombari, Simone, and Marco Mondelli. “Towards Understanding the Word Sensitivity
    of Attention Layers: A Study via Random Features.” <i>41st International Conference
    on Machine Learning</i>, vol. 235, ML Research Press, 2024, pp. 4300–28.'
  short: S. Bombari, M. Mondelli, in:, 41st International Conference on Machine Learning,
    ML Research Press, 2024, pp. 4300–4328.
conference:
  end_date: 2024-07-27
  location: Vienna, Austria
  name: 'ICML: International Conference on Machine Learning'
  start_date: 2024-07-21
corr_author: '1'
das_tickbox: '0'
date_created: 2025-01-30T07:35:49Z
date_published: 2024-07-30T00:00:00Z
date_updated: 2026-10-16T10:42:17Z
day: '30'
department:
- _id: MaMo
external_id:
  arxiv:
  - '2402.02969'
intvolume: '       235'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2402.02969
month: '07'
oa: 1
oa_version: Preprint
page: 4300-4328
project:
- _id: 059876FA-7A3F-11EA-A408-12923DDC885E
  name: Prix Lopez-Loretta 2019 - Marco Mondelli
publication: 41st International Conference on Machine Learning
publication_identifier:
  eissn:
  - 2640-3498
publication_status: published
publisher: ML Research Press
quality_controlled: '1'
related_material:
  record:
  - id: '22857'
    relation: dissertation_contains
    status: public
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: 'Towards understanding the word sensitivity of attention layers: A study via
  random features'
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 235
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '18972'
abstract:
- lang: eng
  text: 'Deep learning models are known to overfit and memorize spurious features
    in the training dataset. While numerous empirical studies have aimed at understanding
    this phenomenon, a rigorous theoretical framework to quantify it is still missing.
    In this paper, we consider spurious features that are uncorrelated with the learning
    task, and we provide a precise characterization of how they are memorized via
    two separate terms: (i) the stability of the model with respect to individual
    training samples, and (ii) the feature alignment between the spurious pattern
    and the full sample. While the first term is well established in learning theory
    and it is connected to the generalization error in classical work, the second
    one is, to the best of our knowledge, novel. Our key technical result gives a
    precise characterization of the feature alignment for the two prototypical settings
    of random features (RF) and neural tangent kernel (NTK) regression. We prove that
    the memorization of spurious features weakens as the generalization capability
    increases and, through the analysis of the feature alignment, we unveil the role
    of the model and of its activation function. Numerical experiments show the predictive
    power of our theory on standard datasets (MNIST, CIFAR-10).'
acknowledgement: "The authors were partially supported by the 2019 LopezLoreta prize,
  and they would like to thank (in alphabetical order) Grigorios Chrysos, Simone Maria
  Giancola, Mahyar\r\nJafari Nodeh, Christoph Lampert, Marco Miani, GuanWen Qiu, and
  Peter Sukenık for helpful discussions."
alternative_title:
- PMLR
article_processing_charge: No
arxiv: 1
author:
- first_name: Simone
  full_name: Bombari, Simone
  id: ca726dda-de17-11ea-bc14-f9da834f63aa
  last_name: Bombari
- first_name: Marco
  full_name: Mondelli, Marco
  id: 27EB676C-8706-11E9-9510-7717E6697425
  last_name: Mondelli
  orcid: 0000-0002-3242-7020
citation:
  ama: 'Bombari S, Mondelli M. How spurious features are memorized: Precise analysis
    for random and NTK features. In: <i>41st International Conference on Machine Learning</i>.
    Vol 235. ML Research Press; 2024:4267-4299.'
  apa: 'Bombari, S., &#38; Mondelli, M. (2024). How spurious features are memorized:
    Precise analysis for random and NTK features. In <i>41st International Conference
    on Machine Learning</i> (Vol. 235, pp. 4267–4299). Vienna, Austria: ML Research
    Press.'
  chicago: 'Bombari, Simone, and Marco Mondelli. “How Spurious Features Are Memorized:
    Precise Analysis for Random and NTK Features.” In <i>41st International Conference
    on Machine Learning</i>, 235:4267–99. ML Research Press, 2024.'
  ieee: 'S. Bombari and M. Mondelli, “How spurious features are memorized: Precise
    analysis for random and NTK features,” in <i>41st International Conference on
    Machine Learning</i>, Vienna, Austria, 2024, vol. 235, pp. 4267–4299.'
  ista: 'Bombari S, Mondelli M. 2024. How spurious features are memorized: Precise
    analysis for random and NTK features. 41st International Conference on Machine
    Learning. ICML: International Conference on Machine Learning, PMLR, vol. 235,
    4267–4299.'
  mla: 'Bombari, Simone, and Marco Mondelli. “How Spurious Features Are Memorized:
    Precise Analysis for Random and NTK Features.” <i>41st International Conference
    on Machine Learning</i>, vol. 235, ML Research Press, 2024, pp. 4267–99.'
  short: S. Bombari, M. Mondelli, in:, 41st International Conference on Machine Learning,
    ML Research Press, 2024, pp. 4267–4299.
conference:
  end_date: 2024-07-27
  location: Vienna, Austria
  name: 'ICML: International Conference on Machine Learning'
  start_date: 2024-07-21
corr_author: '1'
das_tickbox: '0'
date_created: 2025-01-30T07:29:47Z
date_published: 2024-07-30T00:00:00Z
date_updated: 2026-10-16T10:42:37Z
day: '30'
department:
- _id: MaMo
external_id:
  arxiv:
  - '2305.12100'
intvolume: '       235'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2305.12100
month: '07'
oa: 1
oa_version: Preprint
page: 4267-4299
project:
- _id: 059876FA-7A3F-11EA-A408-12923DDC885E
  name: Prix Lopez-Loretta 2019 - Marco Mondelli
publication: 41st International Conference on Machine Learning
publication_identifier:
  eissn:
  - 2640-3498
publication_status: published
publisher: ML Research Press
quality_controlled: '1'
related_material:
  record:
  - id: '22857'
    relation: dissertation_contains
    status: public
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: 'How spurious features are memorized: Precise analysis for random and NTK features'
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 235
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '17330'
abstract:
- lang: eng
  text: In this work we consider the list-decodability and list-recoverability of
    arbitrary q -ary codes, for all integer values of q ⩾ 2. A code is called ( p
    , L ) q -list-decodable if every radius pn Hamming ball contains less than L codewords;
    ( p , ℓ, L ) q -recoverability is a generalization where we place radius pn Hamming
    balls on every point of a combinatorial rectangle with side length ℓ and again
    stipulate that there be less than L codewords. Our main contribution is to precisely
    calculate the maximum value of p for which there exist infinite families of positive
    rate ( p , ℓ, L ) q -list-recoverable codes, the quantity we call the zero-rate
    threshold . Denoting this value by p *, we in fact show that codes correcting
    a p * + ε fraction of errors must have size O ε (1), i.e., independent of n .
    Such a result is typically referred to as a “Plotkin bound.” To complement this,
    a standard random code with expurgation construction shows that there exist positive
    rate codes correcting a p * − ε fraction of errors. We also follow a classical
    proof template (typically attributed to Elias and Bassalygo) to derive from the
    zero-rate threshold other tradeoffs between rate and decoding radius for list-decoding
    and list-recovery. Technically, proving the Plotkin bound boils down to demon-strating
    the Schur convexity of a certain function defined on the q -simplex as well as
    the convexity of a univariate function derived from it. We remark that an earlier
    argument claimed similar results for q -ary list-decoding; however, we point out
    that this earlier proof is flawed.
acknowledgement: Part of this work was done while Nicolas Resch was affiliated with
  the Centrum Wiskunde & Informatica and supported in part by ERC H2020 grant No.74079
  (ALGSTRONGCRYPTO). Chen Yuan is supported in part by the National Key Research and
  Development Projects under Grant 2022YFA1004900 and Grant 2021YFE0109900, the National
  Natural Science Foundation of China under Grant 12101403 and Grant 12031011.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Nicolas
  full_name: Resch, Nicolas
  last_name: Resch
- first_name: Chen
  full_name: Yuan, Chen
  last_name: Yuan
- first_name: Yihan
  full_name: Zhang, Yihan
  id: 2ce5da42-b2ea-11eb-bba5-9f264e9d002c
  last_name: Zhang
  orcid: 0000-0002-6465-6258
citation:
  ama: Resch N, Yuan C, Zhang Y. Zero-rate thresholds and new capacity bounds for
    list-decoding and list-recovery. <i>IEEE Transactions on Information Theory</i>.
    2024;70(9):6211-6238. doi:<a href="https://doi.org/10.1109/TIT.2024.3430842">10.1109/TIT.2024.3430842</a>
  apa: Resch, N., Yuan, C., &#38; Zhang, Y. (2024). Zero-rate thresholds and new capacity
    bounds for list-decoding and list-recovery. <i>IEEE Transactions on Information
    Theory</i>. IEEE. <a href="https://doi.org/10.1109/TIT.2024.3430842">https://doi.org/10.1109/TIT.2024.3430842</a>
  chicago: Resch, Nicolas, Chen Yuan, and Yihan Zhang. “Zero-Rate Thresholds and New
    Capacity Bounds for List-Decoding and List-Recovery.” <i>IEEE Transactions on
    Information Theory</i>. IEEE, 2024. <a href="https://doi.org/10.1109/TIT.2024.3430842">https://doi.org/10.1109/TIT.2024.3430842</a>.
  ieee: N. Resch, C. Yuan, and Y. Zhang, “Zero-rate thresholds and new capacity bounds
    for list-decoding and list-recovery,” <i>IEEE Transactions on Information Theory</i>,
    vol. 70, no. 9. IEEE, pp. 6211–6238, 2024.
  ista: Resch N, Yuan C, Zhang Y. 2024. Zero-rate thresholds and new capacity bounds
    for list-decoding and list-recovery. IEEE Transactions on Information Theory.
    70(9), 6211–6238.
  mla: Resch, Nicolas, et al. “Zero-Rate Thresholds and New Capacity Bounds for List-Decoding
    and List-Recovery.” <i>IEEE Transactions on Information Theory</i>, vol. 70, no.
    9, IEEE, 2024, pp. 6211–38, doi:<a href="https://doi.org/10.1109/TIT.2024.3430842">10.1109/TIT.2024.3430842</a>.
  short: N. Resch, C. Yuan, Y. Zhang, IEEE Transactions on Information Theory 70 (2024)
    6211–6238.
corr_author: '1'
das_tickbox: '0'
date_created: 2024-07-28T22:01:10Z
date_published: 2024-09-01T00:00:00Z
date_updated: 2026-10-16T10:41:59Z
day: '01'
department:
- _id: MaMo
doi: 10.1109/TIT.2024.3430842
external_id:
  arxiv:
  - '2210.07754'
  isi:
  - '001299623600019'
fulldoi: https://doi.org/10.1109/TIT.2024.3430842
intvolume: '        70'
isi: 1
issue: '9'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2210.07754
month: '09'
oa: 1
oa_version: Preprint
page: 6211-6238
publication: IEEE Transactions on Information Theory
publication_identifier:
  eissn:
  - 1557-9654
  issn:
  - 0018-9448
publication_status: published
publisher: IEEE
quality_controlled: '1'
related_material:
  record:
  - id: '14083'
    relation: earlier_version
    status: public
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Zero-rate thresholds and new capacity bounds for list-decoding and list-recovery
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 70
year: '2024'
...
