---
_id: '14617'
abstract:
- lang: eng
text: Sex chromosomes have evolved independently multiple times, but why some are
conserved for more than 100 million years whereas others turnover rapidly remains
an open question. Here, we examine the homology of sex chromosomes across nine
orders of insects, plus the outgroup springtails. We find that the X chromosome
is likely homologous across insects and springtails; the only exception is in
the Lepidoptera, which has lost the X and now has a ZZ/ZW sex chromosome system.
These results suggest the ancestral insect X chromosome has persisted for more
than 450 million years – the oldest known sex chromosome to date. Further, we
propose that the shrinking of gene content of the Dipteran X chromosome has allowed
for a burst of sex-chromosome turnover that is absent from other speciose insect
orders.
article_processing_charge: No
author:
- first_name: Melissa A
full_name: Toups, Melissa A
id: 4E099E4E-F248-11E8-B48F-1D18A9856A87
last_name: Toups
orcid: 0000-0002-9752-7380
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
citation:
ama: Toups MA, Vicoso B. The X chromosome of insects likely predates the origin
of Class Insecta. 2023. doi:10.5281/ZENODO.8138705
apa: Toups, M. A., & Vicoso, B. (2023). The X chromosome of insects likely predates
the origin of Class Insecta. Zenodo. https://doi.org/10.5281/ZENODO.8138705
chicago: Toups, Melissa A, and Beatriz Vicoso. “The X Chromosome of Insects Likely
Predates the Origin of Class Insecta.” Zenodo, 2023. https://doi.org/10.5281/ZENODO.8138705.
ieee: M. A. Toups and B. Vicoso, “The X chromosome of insects likely predates the
origin of Class Insecta.” Zenodo, 2023.
ista: Toups MA, Vicoso B. 2023. The X chromosome of insects likely predates the
origin of Class Insecta, Zenodo, 10.5281/ZENODO.8138705.
mla: Toups, Melissa A., and Beatriz Vicoso. The X Chromosome of Insects Likely
Predates the Origin of Class Insecta. Zenodo, 2023, doi:10.5281/ZENODO.8138705.
short: M.A. Toups, B. Vicoso, (2023).
date_created: 2023-11-28T08:04:03Z
date_published: 2023-09-15T00:00:00Z
date_updated: 2025-09-09T13:32:05Z
day: '15'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.5281/ZENODO.8138705
has_accepted_license: '1'
main_file_link:
- open_access: '1'
url: https://doi.org/10.5281/zenodo.8138705
month: '09'
oa: 1
oa_version: Published Version
other_data_license: MIT License
publisher: Zenodo
related_material:
record:
- id: '14604'
relation: used_in_publication
status: public
status: public
title: The X chromosome of insects likely predates the origin of Class Insecta
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '14619'
abstract:
- lang: eng
text: Data underlying the publication "A streamlined molecular-dynamics workflow
for computing solubilities of molecular and ionic crystals" (DOI https://doi.org/10.1063/5.0173341).
article_processing_charge: No
author:
- first_name: Bingqing
full_name: Cheng, Bingqing
id: cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9
last_name: Cheng
orcid: 0000-0002-3584-9632
citation:
ama: 'Cheng B. BingqingCheng/solubility: V1.0. 2023. doi:10.5281/ZENODO.8398094'
apa: 'Cheng, B. (2023). BingqingCheng/solubility: V1.0. Zenodo. https://doi.org/10.5281/ZENODO.8398094'
chicago: 'Cheng, Bingqing. “BingqingCheng/Solubility: V1.0.” Zenodo, 2023. https://doi.org/10.5281/ZENODO.8398094.'
ieee: 'B. Cheng, “BingqingCheng/solubility: V1.0.” Zenodo, 2023.'
ista: 'Cheng B. 2023. BingqingCheng/solubility: V1.0, Zenodo, 10.5281/ZENODO.8398094.'
mla: 'Cheng, Bingqing. BingqingCheng/Solubility: V1.0. Zenodo, 2023, doi:10.5281/ZENODO.8398094.'
short: B. Cheng, (2023).
corr_author: '1'
date_created: 2023-11-28T08:32:18Z
date_published: 2023-10-02T00:00:00Z
date_updated: 2025-09-09T13:32:46Z
day: '02'
ddc:
- '530'
department:
- _id: BiCh
doi: 10.5281/ZENODO.8398094
has_accepted_license: '1'
main_file_link:
- open_access: '1'
url: https://doi.org/10.5281/zenodo.8398094
month: '10'
oa: 1
oa_version: Published Version
publisher: Zenodo
related_material:
record:
- id: '14603'
relation: used_in_publication
status: public
status: public
title: 'BingqingCheng/solubility: V1.0'
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
OA_place: publisher
_id: '14622'
abstract:
- lang: eng
text: "This Ph.D. thesis presents a detailed investigation into Variational Quantum
Algorithms\r\n(VQAs), a promising class of quantum algorithms that are well suited
for near-term quantum\r\ncomputation due to their moderate hardware requirements
and resilience to noise. Our\r\nprimary focus lies on two particular types of
VQAs: the Quantum Approximate Optimization\r\nAlgorithm (QAOA), used for solving
binary optimization problems, and the Variational Quantum\r\nEigensolver (VQE),
utilized for finding ground states of quantum many-body systems.\r\nIn the first
part of the thesis, we examine the issue of effective parameter initialization
for\r\nthe QAOA. The work demonstrates that random initialization of the QAOA
often leads to\r\nconvergence in local minima with sub-optimal performance. To
mitigate this issue, we propose\r\nan initialization of QAOA parameters based
on the Trotterized Quantum Annealing (TQA).\r\nWe show that TQA initialization
leads to the same performance as the best of an exponentially\r\nscaling number
of random initializations.\r\nThe second study introduces Transition States (TS),
stationary points with a single direction\r\nof descent, as a tool for systematically
exploring the QAOA optimization landscape. This\r\nleads us to propose a novel
greedy parameter initialization strategy that guarantees for the\r\nenergy to
decrease with increasing number of circuit layers.\r\nIn the third section, we
extend the QAOA to qudit systems, which are higher-dimensional\r\ngeneralizations
of qubits. This chapter provides theoretical insights and practical strategies
for\r\nleveraging the increased computational power of qudits in the context of
quantum optimization\r\nalgorithms and suggests a quantum circuit for implementing
the algorithm on an ion trap\r\nquantum computer.\r\nFinally, we propose an algorithm
to avoid “barren plateaus”, regions in parameter space with\r\nvanishing gradients
that obstruct efficient parameter optimization. This novel approach relies\r\non
defining a notion of weak barren plateaus based on the entropies of local reduced
density\r\nmatrices and showcases how these can be efficiently quantified using
shadow tomography.\r\nTo illustrate the approach we employ the strategy in the
VQE and show that it allows to\r\nsuccessfully avoid barren plateaus in the initialization
and throughout the optimization.\r\nTaken together, this thesis greatly enhances
our understanding of parameter initialization and\r\noptimization in VQAs, expands
the scope of QAOA to higher-dimensional quantum systems,\r\nand presents a method
to address the challenge of barren plateaus using the VQE. These\r\ninsights are
instrumental in advancing the field of near-term quantum computation."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Stefan
full_name: Sack, Stefan
id: dd622248-f6e0-11ea-865d-ce382a1c81a5
last_name: Sack
orcid: 0000-0001-5400-8508
citation:
ama: 'Sack S. Improving variational quantum algorithms : Innovative initialization
techniques and extensions to qudit systems. 2023. doi:10.15479/at:ista:14622'
apa: 'Sack, S. (2023). Improving variational quantum algorithms : Innovative
initialization techniques and extensions to qudit systems. Institute of Science
and Technology Austria. https://doi.org/10.15479/at:ista:14622'
chicago: 'Sack, Stefan. “Improving Variational Quantum Algorithms : Innovative Initialization
Techniques and Extensions to Qudit Systems.” Institute of Science and Technology
Austria, 2023. https://doi.org/10.15479/at:ista:14622.'
ieee: 'S. Sack, “Improving variational quantum algorithms : Innovative initialization
techniques and extensions to qudit systems,” Institute of Science and Technology
Austria, 2023.'
ista: 'Sack S. 2023. Improving variational quantum algorithms : Innovative initialization
techniques and extensions to qudit systems. Institute of Science and Technology
Austria.'
mla: 'Sack, Stefan. Improving Variational Quantum Algorithms : Innovative Initialization
Techniques and Extensions to Qudit Systems. Institute of Science and Technology
Austria, 2023, doi:10.15479/at:ista:14622.'
short: 'S. Sack, Improving Variational Quantum Algorithms : Innovative Initialization
Techniques and Extensions to Qudit Systems, Institute of Science and Technology
Austria, 2023.'
corr_author: '1'
date_created: 2023-11-28T10:58:13Z
date_published: 2023-11-30T00:00:00Z
date_updated: 2026-04-07T13:53:47Z
day: '30'
ddc:
- '530'
degree_awarded: PhD
department:
- _id: GradSch
- _id: MaSe
doi: 10.15479/at:ista:14622
ec_funded: 1
file:
- access_level: open_access
checksum: 068fd3570506ec42b2faa390de784bc4
content_type: application/pdf
creator: ssack
date_created: 2023-11-30T15:53:10Z
date_updated: 2024-11-30T23:30:03Z
embargo: 2024-11-30
file_id: '14635'
file_name: PhD_Thesis.pdf
file_size: 11947523
relation: main_file
- access_level: closed
checksum: 0fa3bc0d108aed0ac59d2c6beef2220a
content_type: application/zip
creator: ssack
date_created: 2023-11-30T15:54:11Z
date_updated: 2024-11-30T23:30:03Z
embargo_to: open_access
file_id: '14636'
file_name: PhD Thesis (1).zip
file_size: 18422964
relation: source_file
file_date_updated: 2024-11-30T23:30:03Z
has_accepted_license: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '11'
oa: 1
oa_version: Published Version
page: '142'
project:
- _id: bd660c93-d553-11ed-ba76-fb0fb6f49c0d
name: IMB PhD Nomination Fellowship - Stefan Sack
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '850899'
name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '13125'
relation: part_of_dissertation
status: public
- id: '11471'
relation: part_of_dissertation
status: public
- id: '9760'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
title: 'Improving variational quantum algorithms : Innovative initialization techniques
and extensions to qudit systems'
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2023'
...
---
_id: '14628'
abstract:
- lang: eng
text: We introduce a compact, intuitive procedural graph representation for cellular
metamaterials, which are small-scale, tileable structures that can be architected
to exhibit many useful material properties. Because the structures’ “architectures”
vary widely—with elements such as beams, thin shells, and solid bulks—it is difficult
to explore them using existing representations. Generic approaches like voxel
grids are versatile, but it is cumbersome to represent and edit individual structures;
architecture-specific approaches address these issues, but are incompatible with
one another. By contrast, our procedural graph succinctly represents the construction
process for any structure using a simple skeleton annotated with spatially varying
thickness. To express the highly constrained triply periodic minimal surfaces
(TPMS) in this manner, we present the first fully automated version of the conjugate
surface construction method, which allows novices to create complex TPMS from
intuitive input. We demonstrate our representation’s expressiveness, accuracy,
and compactness by constructing a wide range of established structures and hundreds
of novel structures with diverse architectures and material properties. We also
conduct a user study to verify our representation’s ease-of-use and ability to
expand engineers’ capacity for exploration.
acknowledgement: "The authors thank Mina Konaković Luković and Michael Foshey for
their early contributions to this project, David Palmer and Paul Zhang for their
insightful discussions about minimal surfaces and the CSCM, Julian Panetta for providing
the Elastic Textures code, and Hannes Hergeth for his feedback and support. We also
thank our user study participants and anonymous reviewers.\r\nThis material is based
upon work supported by the National Science Foundation\r\n(NSF) Graduate Research
Fellowship under Grant No. 2141064; the MIT Morningside\r\nAcademy for Design Fellowship;
the Defense Advanced Research Projects Agency\r\n(DARPA) Grant No. FA8750-20-C-0075;
the ERC Consolidator Grant No. 101045083,\r\n“CoDiNA: Computational Discovery of
Numerical Algorithms for Animation and Simulation of Natural Phenomena”; and the
NewSat project, which is co-funded by the Operational Program for Competitiveness
and Internationalisation (COMPETE2020), Portugal 2020, the European Regional Development
Fund (ERDF), and the Portuguese Foundation for Science and Technology (FTC) under
the MIT Portugal program."
article_number: '168'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Liane
full_name: Makatura, Liane
last_name: Makatura
- first_name: Bohan
full_name: Wang, Bohan
last_name: Wang
- first_name: Yi-Lu
full_name: Chen, Yi-Lu
id: 0b467602-dbcd-11ea-9d1d-ed480aa46b70
last_name: Chen
- first_name: Bolei
full_name: Deng, Bolei
last_name: Deng
- first_name: Christopher J
full_name: Wojtan, Christopher J
id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
last_name: Wojtan
orcid: 0000-0001-6646-5546
- first_name: Bernd
full_name: Bickel, Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
- first_name: Wojciech
full_name: Matusik, Wojciech
last_name: Matusik
citation:
ama: 'Makatura L, Wang B, Chen Y-L, et al. Procedural metamaterials: A unified procedural
graph for metamaterial design. ACM Transactions on Graphics. 2023;42(5).
doi:10.1145/3605389'
apa: 'Makatura, L., Wang, B., Chen, Y.-L., Deng, B., Wojtan, C., Bickel, B., &
Matusik, W. (2023). Procedural metamaterials: A unified procedural graph for metamaterial
design. ACM Transactions on Graphics. Association for Computing Machinery.
https://doi.org/10.1145/3605389'
chicago: 'Makatura, Liane, Bohan Wang, Yi-Lu Chen, Bolei Deng, Chris Wojtan, Bernd
Bickel, and Wojciech Matusik. “Procedural Metamaterials: A Unified Procedural
Graph for Metamaterial Design.” ACM Transactions on Graphics. Association
for Computing Machinery, 2023. https://doi.org/10.1145/3605389.'
ieee: 'L. Makatura et al., “Procedural metamaterials: A unified procedural
graph for metamaterial design,” ACM Transactions on Graphics, vol. 42,
no. 5. Association for Computing Machinery, 2023.'
ista: 'Makatura L, Wang B, Chen Y-L, Deng B, Wojtan C, Bickel B, Matusik W. 2023.
Procedural metamaterials: A unified procedural graph for metamaterial design.
ACM Transactions on Graphics. 42(5), 168.'
mla: 'Makatura, Liane, et al. “Procedural Metamaterials: A Unified Procedural Graph
for Metamaterial Design.” ACM Transactions on Graphics, vol. 42, no. 5,
168, Association for Computing Machinery, 2023, doi:10.1145/3605389.'
short: L. Makatura, B. Wang, Y.-L. Chen, B. Deng, C. Wojtan, B. Bickel, W. Matusik,
ACM Transactions on Graphics 42 (2023).
date_created: 2023-11-29T15:02:03Z
date_published: 2023-10-01T00:00:00Z
date_updated: 2025-09-09T13:33:58Z
day: '01'
ddc:
- '531'
- '006'
department:
- _id: GradSch
- _id: ChWo
- _id: BeBi
doi: 10.1145/3605389
external_id:
isi:
- '001086833300007'
file:
- access_level: open_access
checksum: 0192f597d7a2ceaf89baddfd6190d4c8
content_type: application/zip
creator: yichen
date_created: 2023-11-29T15:16:01Z
date_updated: 2023-11-29T15:16:01Z
file_id: '14630'
file_name: tog-22-0089-File004.zip
file_size: 95467870
relation: main_file
success: 1
- access_level: open_access
checksum: 7fb024963be81933494f38de191e4710
content_type: application/zip
creator: yichen
date_created: 2023-11-29T15:16:01Z
date_updated: 2023-11-29T15:16:01Z
file_id: '14631'
file_name: tog-22-0089-File005.zip
file_size: 103731880
relation: main_file
success: 1
- access_level: open_access
checksum: b7d6829ce396e21cac9fae0ec7130a6b
content_type: application/pdf
creator: dernst
date_created: 2023-12-04T08:04:14Z
date_updated: 2023-12-04T08:04:14Z
file_id: '14638'
file_name: 2023_ACMToG_Makatura.pdf
file_size: 57067476
relation: main_file
success: 1
file_date_updated: 2023-12-04T08:04:14Z
has_accepted_license: '1'
intvolume: ' 42'
isi: 1
issue: '5'
keyword:
- Computer Graphics and Computer-Aided Design
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 34bc2376-11ca-11ed-8bc3-9a3b3961a088
grant_number: '101045083'
name: Computational Discovery of Numerical Algorithms for Animation and Simulation
of Natural Phenomena
publication: ACM Transactions on Graphics
publication_identifier:
eissn:
- 1557-7368
issn:
- 0730-0301
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Procedural metamaterials: A unified procedural graph for metamaterial design'
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 42
year: '2023'
...
---
_id: '14639'
abstract:
- lang: eng
text: "Background: Biallelic variants in OGDHL, encoding part of the α-ketoglutarate
dehydrogenase complex, have been associated with highly heterogeneous neurological
and neurodevelopmental disorders. However, the validity of this association remains
to be confirmed. A second OGDHL patient cohort was recruited to carefully assess
the gene-disease relationship.\r\nMethods: Using an unbiased genotype-first approach,
we screened large, multiethnic aggregated sequencing datasets worldwide for biallelic
OGDHL variants. We used CRISPR/Cas9 to generate zebrafish knockouts of ogdhl,
ogdh paralogs, and dhtkd1 to investigate functional relationships and impact during
development. Functional complementation with patient variant transcripts was conducted
to systematically assess protein functionality as a readout for pathogenicity.\r\nResults:
A cohort of 14 individuals from 12 unrelated families exhibited highly variable
clinical phenotypes, with the majority of them presenting at least one additional
variant, potentially accounting for a blended phenotype and complicating phenotypic
understanding. We also uncovered extreme clinical heterogeneity and high allele
frequencies, occasionally incompatible with a fully penetrant recessive disorder.
Human cDNA of previously described and new variants were tested in an ogdhl zebrafish
knockout model, adding functional evidence for variant reclassification. We disclosed
evidence of hypomorphic alleles as well as a loss-of-function variant without
deleterious effects in zebrafish variant testing also showing discordant familial
segregation, challenging the relationship of OGDHL as a conventional Mendelian
gene. Going further, we uncovered evidence for a complex compensatory relationship
among OGDH, OGDHL, and DHTKD1 isoenzymes that are associated with neurodevelopmental
disorders and exhibit complex transcriptional compensation patterns with partial
functional redundancy.\r\nConclusions: Based on the results of genetic, clinical,
and functional studies, we formed three hypotheses in which to frame observations:
biallelic OGDHL variants lead to a highly variable monogenic disorder, variants
in OGDHL are following a complex pattern of inheritance, or they may not be causative
at all. Our study further highlights the continuing challenges of assessing the
validity of reported disease-gene associations and effects of variants identified
in these genes. This is particularly more complicated in making genetic diagnoses
based on identification of variants in genes presenting a highly heterogenous
phenotype such as “OGDHL-related disorders”."
article_number: '102'
article_processing_charge: Yes
article_type: original
author:
- first_name: Sheng-Jia
full_name: Lin, Sheng-Jia
last_name: Lin
- first_name: Barbara
full_name: Vona, Barbara
last_name: Vona
- first_name: Tracy
full_name: Lau, Tracy
last_name: Lau
- first_name: Kevin
full_name: Huang, Kevin
id: 3b3d2888-1ff6-11ee-9fa6-8f209ca91fe3
last_name: Huang
orcid: 0000-0002-2512-7812
- first_name: Maha S.
full_name: Zaki, Maha S.
last_name: Zaki
- first_name: Huda Shujaa
full_name: Aldeen, Huda Shujaa
last_name: Aldeen
- first_name: Ehsan Ghayoor
full_name: Karimiani, Ehsan Ghayoor
last_name: Karimiani
- first_name: Clarissa
full_name: Rocca, Clarissa
last_name: Rocca
- first_name: Mahmoud M.
full_name: Noureldeen, Mahmoud M.
last_name: Noureldeen
- first_name: Ahmed K.
full_name: Saad, Ahmed K.
last_name: Saad
- first_name: Cassidy
full_name: Petree, Cassidy
last_name: Petree
- first_name: Tobias
full_name: Bartolomaeus, Tobias
last_name: Bartolomaeus
- first_name: Rami
full_name: Abou Jamra, Rami
last_name: Abou Jamra
- first_name: Giovanni
full_name: Zifarelli, Giovanni
last_name: Zifarelli
- first_name: Aditi
full_name: Gotkhindikar, Aditi
last_name: Gotkhindikar
- first_name: Ingrid M.
full_name: Wentzensen, Ingrid M.
last_name: Wentzensen
- first_name: Mingjuan
full_name: Liao, Mingjuan
last_name: Liao
- first_name: Emalyn Elise
full_name: Cork, Emalyn Elise
last_name: Cork
- first_name: Pratishtha
full_name: Varshney, Pratishtha
last_name: Varshney
- first_name: Narges
full_name: Hashemi, Narges
last_name: Hashemi
- first_name: Mohammad Hasan
full_name: Mohammadi, Mohammad Hasan
last_name: Mohammadi
- first_name: Aboulfazl
full_name: Rad, Aboulfazl
last_name: Rad
- first_name: Juanita
full_name: Neira, Juanita
last_name: Neira
- first_name: Mehran Beiraghi
full_name: Toosi, Mehran Beiraghi
last_name: Toosi
- first_name: Cordula
full_name: Knopp, Cordula
last_name: Knopp
- first_name: Ingo
full_name: Kurth, Ingo
last_name: Kurth
- first_name: Thomas D.
full_name: Challman, Thomas D.
last_name: Challman
- first_name: Rebecca
full_name: Smith, Rebecca
last_name: Smith
- first_name: Asmahan
full_name: Abdalla, Asmahan
last_name: Abdalla
- first_name: Thomas
full_name: Haaf, Thomas
last_name: Haaf
- first_name: Mohnish
full_name: Suri, Mohnish
last_name: Suri
- first_name: Manali
full_name: Joshi, Manali
last_name: Joshi
- first_name: Wendy K.
full_name: Chung, Wendy K.
last_name: Chung
- first_name: Andres
full_name: Moreno-De-Luca, Andres
last_name: Moreno-De-Luca
- first_name: Henry
full_name: Houlden, Henry
last_name: Houlden
- first_name: Reza
full_name: Maroofian, Reza
last_name: Maroofian
- first_name: Gaurav K.
full_name: Varshney, Gaurav K.
last_name: Varshney
citation:
ama: Lin S-J, Vona B, Lau T, et al. Evaluating the association of biallelic OGDHL
variants with significant phenotypic heterogeneity. Genome Medicine. 2023;15.
doi:10.1186/s13073-023-01258-4
apa: Lin, S.-J., Vona, B., Lau, T., Huang, K., Zaki, M. S., Aldeen, H. S., … Varshney,
G. K. (2023). Evaluating the association of biallelic OGDHL variants with significant
phenotypic heterogeneity. Genome Medicine. Springer Nature. https://doi.org/10.1186/s13073-023-01258-4
chicago: Lin, Sheng-Jia, Barbara Vona, Tracy Lau, Kevin Huang, Maha S. Zaki, Huda
Shujaa Aldeen, Ehsan Ghayoor Karimiani, et al. “Evaluating the Association of
Biallelic OGDHL Variants with Significant Phenotypic Heterogeneity.” Genome
Medicine. Springer Nature, 2023. https://doi.org/10.1186/s13073-023-01258-4.
ieee: S.-J. Lin et al., “Evaluating the association of biallelic OGDHL variants
with significant phenotypic heterogeneity,” Genome Medicine, vol. 15. Springer
Nature, 2023.
ista: Lin S-J, Vona B, Lau T, Huang K, Zaki MS, Aldeen HS, Karimiani EG, Rocca C,
Noureldeen MM, Saad AK, Petree C, Bartolomaeus T, Abou Jamra R, Zifarelli G, Gotkhindikar
A, Wentzensen IM, Liao M, Cork EE, Varshney P, Hashemi N, Mohammadi MH, Rad A,
Neira J, Toosi MB, Knopp C, Kurth I, Challman TD, Smith R, Abdalla A, Haaf T,
Suri M, Joshi M, Chung WK, Moreno-De-Luca A, Houlden H, Maroofian R, Varshney
GK. 2023. Evaluating the association of biallelic OGDHL variants with significant
phenotypic heterogeneity. Genome Medicine. 15, 102.
mla: Lin, Sheng-Jia, et al. “Evaluating the Association of Biallelic OGDHL Variants
with Significant Phenotypic Heterogeneity.” Genome Medicine, vol. 15, 102,
Springer Nature, 2023, doi:10.1186/s13073-023-01258-4.
short: S.-J. Lin, B. Vona, T. Lau, K. Huang, M.S. Zaki, H.S. Aldeen, E.G. Karimiani,
C. Rocca, M.M. Noureldeen, A.K. Saad, C. Petree, T. Bartolomaeus, R. Abou Jamra,
G. Zifarelli, A. Gotkhindikar, I.M. Wentzensen, M. Liao, E.E. Cork, P. Varshney,
N. Hashemi, M.H. Mohammadi, A. Rad, J. Neira, M.B. Toosi, C. Knopp, I. Kurth,
T.D. Challman, R. Smith, A. Abdalla, T. Haaf, M. Suri, M. Joshi, W.K. Chung, A.
Moreno-De-Luca, H. Houlden, R. Maroofian, G.K. Varshney, Genome Medicine 15 (2023).
date_created: 2023-12-04T08:10:55Z
date_published: 2023-11-23T00:00:00Z
date_updated: 2023-12-04T08:17:22Z
day: '23'
ddc:
- '570'
doi: 10.1186/s13073-023-01258-4
extern: '1'
file:
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checksum: 279efd212005549aba817a487d56d363
content_type: application/pdf
creator: dernst
date_created: 2023-12-04T08:15:43Z
date_updated: 2023-12-04T08:15:43Z
file_id: '14640'
file_name: 2023_GenomeMed_Lin.pdf
file_size: 14791081
relation: main_file
success: 1
file_date_updated: 2023-12-04T08:15:43Z
has_accepted_license: '1'
intvolume: ' 15'
keyword:
- Genetics (clinical)
- Genetics
- Molecular Biology
- Molecular Medicine
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '11'
oa: 1
oa_version: Published Version
publication: Genome Medicine
publication_identifier:
issn:
- 1756-994X
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Evaluating the association of biallelic OGDHL variants with significant phenotypic
heterogeneity
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2023'
...
---
OA_place: publisher
_id: '14641'
abstract:
- lang: eng
text: "Mutation rates represent the net result of complex interactions among various\r\ncellular
processes and can dramatically influence the evolutionary fate of\r\nmicrobial
populations. However, many popular techniques used to study\r\nmutations are subject
to the confounding effects of heredity and the subtleties\r\nof adaptation to
selection, all of which make it difficult to observe any dynamic\r\nresponses
of mutation rates to fitness challenges. Furthermore, in spite of the\r\nubiquity
of quorum sensing systems across the bacterial domain and relevance\r\nfor many
physiological behaviors, the effects of such mechanisms on mutation\r\nrate and
adaptation remain poorly understood. In the following work, I\r\npresent the development
of a microfluidic droplet-based method to measure\r\nsingle base-pair mutation
rates in growing populations of the bacterium\r\nEscherichia coli. I use this
method to observe a stress-induced increase in\r\nmutation rate that is mediated
by luxS, a highly conserved bacterial quorum\r\nsensing component. I also show
that the aforementioned increase in mutation\r\nrate, and its associated control
by luxS, corresponds to a higher degree of\r\nadaptability under competitive environments."
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
- _id: CampIT
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Mike
full_name: Hennessey-Wesen, Mike
id: 3F338C72-F248-11E8-B48F-1D18A9856A87
last_name: Hennessey-Wesen
citation:
ama: Hennessey-Wesen M. Adaptive mutation in E. coli modulated by luxS. 2023. doi:10.15479/at:ista:14641
apa: Hennessey-Wesen, M. (2023). Adaptive mutation in E. coli modulated by luxS.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:14641
chicago: Hennessey-Wesen, Mike. “Adaptive Mutation in E. Coli Modulated by LuxS.”
Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:14641.
ieee: M. Hennessey-Wesen, “Adaptive mutation in E. coli modulated by luxS,” Institute
of Science and Technology Austria, 2023.
ista: Hennessey-Wesen M. 2023. Adaptive mutation in E. coli modulated by luxS. Institute
of Science and Technology Austria.
mla: Hennessey-Wesen, Mike. Adaptive Mutation in E. Coli Modulated by LuxS.
Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:14641.
short: M. Hennessey-Wesen, Adaptive Mutation in E. Coli Modulated by LuxS, Institute
of Science and Technology Austria, 2023.
corr_author: '1'
date_created: 2023-12-04T13:17:37Z
date_published: 2023-11-30T00:00:00Z
date_updated: 2026-04-07T13:29:59Z
day: '30'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: BjHo
doi: 10.15479/at:ista:14641
ec_funded: 1
file:
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content_type: application/pdf
creator: mhenness
date_created: 2023-12-06T13:14:15Z
date_updated: 2025-07-17T11:20:25Z
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file_size: 21282155
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checksum: 902102d26d30e74dbd6cdd70a65820c3
content_type: application/pdf
creator: cchlebak
date_created: 2025-05-20T12:59:12Z
date_updated: 2025-05-20T22:31:34Z
description: for printing purposes only
embargo_to: open_access
file_id: '19720'
file_name: 2023_Hennessey_Michael_Thesis_print.pdf
file_size: 45847968
relation: other
title: Print version
file_date_updated: 2025-07-17T11:20:25Z
has_accepted_license: '1'
keyword:
- microfluidics
- miceobiology
- mutations
- quorum sensing
language:
- iso: eng
month: '11'
oa_version: Published Version
page: '104'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
title: Adaptive mutation in E. coli modulated by luxS
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2023'
...
---
_id: '14644'
abstract:
- lang: eng
text: Transcription by RNA polymerase II (Pol II) can be repressed by noncoding
RNA, including the human RNA Alu. However, the mechanism by which endogenous RNAs
repress transcription remains unclear. Here we present cryo-electron microscopy
structures of Pol II bound to Alu RNA, which reveal that Alu RNA mimics how DNA
and RNA bind to Pol II during transcription elongation. Further, we show how domains
of the general transcription factor TFIIF affect complex dynamics and control
repressive activity. Together, we reveal how a non-coding RNA can regulate mammalian
gene expression.
acknowledged_ssus:
- _id: LifeSc
- _id: EM-Fac
- _id: PreCl
acknowledgement: "We thank B. Kaczmarek and other members of the Bernecky lab for
helpful discussions. We thank V.-V. Hodirnau for SerialEM data collection and support
with EPU data collection. We thank D. Slade for the wild type TFIIF expression\r\nplasmid.
We thank N. Thompson and R. Burgess for the 8WG16 hybridoma cell line. We thank
C. Plaschka and M. Loose for critical reading of the manuscript. This work was supported
by Austrian Science Fund (FWF) grant P34185. This research was further supported
by the Scientific Service Units (SSU) of IST Austria through resources provided
by the Lab Support Facility (LSF), Electron Microscopy Facility (EMF), Scientific
Computing (SciComp), and the Preclinical Facility (PCF)."
article_processing_charge: No
author:
- first_name: Katarina
full_name: Tluckova, Katarina
id: 4AC7D980-F248-11E8-B48F-1D18A9856A87
last_name: Tluckova
- first_name: Anita P
full_name: Testa Salmazo, Anita P
id: 41F1F098-F248-11E8-B48F-1D18A9856A87
last_name: Testa Salmazo
- first_name: Carrie A
full_name: Bernecky, Carrie A
id: 2CB9DFE2-F248-11E8-B48F-1D18A9856A87
last_name: Bernecky
orcid: 0000-0003-0893-7036
citation:
ama: Tluckova K, Testa Salmazo AP, Bernecky C. Mechanism of mammalian transcriptional
repression by noncoding RNA. doi:10.15479/AT:ISTA:14644
apa: Tluckova, K., Testa Salmazo, A. P., & Bernecky, C. (n.d.). Mechanism of
mammalian transcriptional repression by noncoding RNA. Institute of Science and
Technology Austria. https://doi.org/10.15479/AT:ISTA:14644
chicago: Tluckova, Katarina, Anita P Testa Salmazo, and Carrie Bernecky. “Mechanism
of Mammalian Transcriptional Repression by Noncoding RNA.” Institute of Science
and Technology Austria, n.d. https://doi.org/10.15479/AT:ISTA:14644.
ieee: K. Tluckova, A. P. Testa Salmazo, and C. Bernecky, “Mechanism of mammalian
transcriptional repression by noncoding RNA.” Institute of Science and Technology
Austria.
ista: Tluckova K, Testa Salmazo AP, Bernecky C. Mechanism of mammalian transcriptional
repression by noncoding RNA. 10.15479/AT:ISTA:14644.
mla: Tluckova, Katarina, et al. Mechanism of Mammalian Transcriptional Repression
by Noncoding RNA. Institute of Science and Technology Austria, doi:10.15479/AT:ISTA:14644.
short: K. Tluckova, A.P. Testa Salmazo, C. Bernecky, (n.d.).
corr_author: '1'
date_created: 2023-12-04T14:51:00Z
date_published: 2023-12-05T00:00:00Z
date_updated: 2025-11-20T10:28:37Z
day: '05'
ddc:
- '572'
doi: 10.15479/AT:ISTA:14644
file:
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checksum: c45608cb97ee36d7b50ba518db8e07b0
content_type: application/pdf
creator: dernst
date_created: 2023-12-05T10:37:02Z
date_updated: 2023-12-05T10:37:02Z
file_id: '14646'
file_name: 2023_Tluckova_etal_REx.pdf
file_size: 4892920
relation: main_file
success: 1
file_date_updated: 2023-12-05T10:37:02Z
has_accepted_license: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '12'
oa: 1
oa_version: Submitted Version
project:
- _id: c08a6700-5a5b-11eb-8a69-82a722b2bc30
grant_number: P34185
name: Regulation of mammalian transcription by noncoding RNA
publication_status: draft
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '18778'
relation: later_version
status: public
status: public
title: Mechanism of mammalian transcriptional repression by noncoding RNA
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '14650'
abstract:
- lang: eng
text: We study the out-of-equilibrium quantum dynamics of dipolar polarons, i.e.,
impurities immersed in a dipolar Bose-Einstein condensate, after a quench of the
impurity-boson interaction. We show that the dipolar nature of the condensate
and of the impurity results in anisotropic relaxation dynamics, in particular,
anisotropic dressing of the polaron. More relevantly for cold-atom setups, quench
dynamics is strongly affected by the interplay between dipolar anisotropy and
trap geometry. Our findings pave the way for simulating impurities in anisotropic
media utilizing experiments with dipolar mixtures.
acknowledgement: "We thank Lauriane Chomaz for useful discussions and comments on
the manuscript. We also\r\nthank Ragheed Al Hyder for comments on the manuscript.\r\nG.B.
acknowledges support from the Austrian Science Fund (FWF),\r\nunder Project No.
M2641-N27. This work is supported by the Deutsche Forschungsgemeinschaft (DFG, German
Research Foundation) under Germany’s Excellence Strategy EXC2181/1-\r\n390900948
(the Heidelberg STRUCTURES Excellence Cluster). A. G. V. acknowledges support from
the European Union’s Horizon 2020 research and innovation programme under the\r\nMarie
Skłodowska-Curie Grant Agreement No. 754411. L.A.P.A acknowledges by the PNRR\r\nMUR
project PE0000023 - NQSTI and the Deutsche Forschungsgemeinschaft (DFG, German\r\nResearch
Foundation) under Germany’s Excellence Strategy - EXC - 2123 Quantum Frontiers390837967
and FOR2247."
article_number: '232'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Artem
full_name: Volosniev, Artem
id: 37D278BC-F248-11E8-B48F-1D18A9856A87
last_name: Volosniev
orcid: 0000-0003-0393-5525
- first_name: Giacomo
full_name: Bighin, Giacomo
id: 4CA96FD4-F248-11E8-B48F-1D18A9856A87
last_name: Bighin
orcid: 0000-0001-8823-9777
- first_name: Luis
full_name: Santos, Luis
last_name: Santos
- first_name: Luisllu A.
full_name: Peña Ardila, Luisllu A.
last_name: Peña Ardila
citation:
ama: Volosniev A, Bighin G, Santos L, Peña Ardila LA. Non-equilibrium dynamics of
dipolar polarons. SciPost Physics. 2023;15(6). doi:10.21468/scipostphys.15.6.232
apa: Volosniev, A., Bighin, G., Santos, L., & Peña Ardila, L. A. (2023). Non-equilibrium
dynamics of dipolar polarons. SciPost Physics. SciPost Foundation. https://doi.org/10.21468/scipostphys.15.6.232
chicago: Volosniev, Artem, Giacomo Bighin, Luis Santos, and Luisllu A. Peña Ardila.
“Non-Equilibrium Dynamics of Dipolar Polarons.” SciPost Physics. SciPost
Foundation, 2023. https://doi.org/10.21468/scipostphys.15.6.232.
ieee: A. Volosniev, G. Bighin, L. Santos, and L. A. Peña Ardila, “Non-equilibrium
dynamics of dipolar polarons,” SciPost Physics, vol. 15, no. 6. SciPost
Foundation, 2023.
ista: Volosniev A, Bighin G, Santos L, Peña Ardila LA. 2023. Non-equilibrium dynamics
of dipolar polarons. SciPost Physics. 15(6), 232.
mla: Volosniev, Artem, et al. “Non-Equilibrium Dynamics of Dipolar Polarons.” SciPost
Physics, vol. 15, no. 6, 232, SciPost Foundation, 2023, doi:10.21468/scipostphys.15.6.232.
short: A. Volosniev, G. Bighin, L. Santos, L.A. Peña Ardila, SciPost Physics 15
(2023).
corr_author: '1'
date_created: 2023-12-10T13:03:07Z
date_published: 2023-12-07T00:00:00Z
date_updated: 2025-09-09T13:34:34Z
day: '07'
ddc:
- '530'
department:
- _id: MiLe
doi: 10.21468/scipostphys.15.6.232
ec_funded: 1
external_id:
arxiv:
- '2305.17969'
isi:
- '001121864100003'
file:
- access_level: open_access
checksum: e664372a1fe9d628a9bb1d135ebab7d8
content_type: application/pdf
creator: dernst
date_created: 2023-12-11T07:42:04Z
date_updated: 2023-12-11T07:42:04Z
file_id: '14669'
file_name: 2023_SciPostPhysics_Volosniev.pdf
file_size: 3543541
relation: main_file
success: 1
file_date_updated: 2023-12-11T07:42:04Z
has_accepted_license: '1'
intvolume: ' 15'
isi: 1
issue: '6'
keyword:
- General Physics and Astronomy
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 26986C82-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02641
name: A path-integral approach to composite impurities
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: SciPost Physics
publication_identifier:
issn:
- 2542-4653
publication_status: published
publisher: SciPost Foundation
quality_controlled: '1'
scopus_import: '1'
status: public
title: Non-equilibrium dynamics of dipolar polarons
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 15
year: '2023'
...
---
OA_place: publisher
_id: '14651'
abstract:
- lang: eng
text: 'For self-incompatibility (SI) to be stable in a population, theory predicts
that sufficient inbreeding depression (ID) is required: the fitness of offspring
from self-mated individuals must be low enough to prevent the spread of self-compatibility
(SC). Reviews of natural plant populations have supported this theory, with SI
species generally showing high levels of ID. However, there is thought to be an
under-sampling of self-incompatible taxa in the current literature. In this thesis,
I study inbreeding depression in the SI plant species Antirrhinum majus using
both greenhouse crosses and a large collected field dataset. Additionally, the
gametophytic S-locus of A. majus is highly heterozygous and polymorphic, thus
making assembly and discovery of S-alleles very difficult. Here, 206 new alleles
of the male component SLFs are presented, along with a phylogeny showing the high
conservation with alleles from another Antirrhinum species. Lastly, selected sites
within the protein structure of SLFs are investigated, with one site in particular
highlighted as potentially being involved in the SI recognition mechanism.'
acknowledged_ssus:
- _id: ScienComp
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Louise S
full_name: Arathoon, Louise S
id: 2CFCFF98-F248-11E8-B48F-1D18A9856A87
last_name: Arathoon
orcid: 0000-0003-1771-714X
citation:
ama: Arathoon LS. Investigating inbreeding depression and the self-incompatibility
locus of Antirrhinum majus. 2023. doi:10.15479/at:ista:14651
apa: Arathoon, L. S. (2023). Investigating inbreeding depression and the self-incompatibility
locus of Antirrhinum majus. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:14651
chicago: Arathoon, Louise S. “Investigating Inbreeding Depression and the Self-Incompatibility
Locus of Antirrhinum Majus.” Institute of Science and Technology Austria, 2023.
https://doi.org/10.15479/at:ista:14651.
ieee: L. S. Arathoon, “Investigating inbreeding depression and the self-incompatibility
locus of Antirrhinum majus,” Institute of Science and Technology Austria, 2023.
ista: Arathoon LS. 2023. Investigating inbreeding depression and the self-incompatibility
locus of Antirrhinum majus. Institute of Science and Technology Austria.
mla: Arathoon, Louise S. Investigating Inbreeding Depression and the Self-Incompatibility
Locus of Antirrhinum Majus. Institute of Science and Technology Austria, 2023,
doi:10.15479/at:ista:14651.
short: L.S. Arathoon, Investigating Inbreeding Depression and the Self-Incompatibility
Locus of Antirrhinum Majus, Institute of Science and Technology Austria, 2023.
corr_author: '1'
date_created: 2023-12-11T19:30:37Z
date_published: 2023-12-12T00:00:00Z
date_updated: 2026-04-07T13:28:30Z
day: '12'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: NiBa
doi: 10.15479/at:ista:14651
ec_funded: 1
file:
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content_type: application/pdf
creator: larathoo
date_created: 2023-12-13T15:37:55Z
date_updated: 2023-12-13T15:37:55Z
file_id: '14684'
file_name: Phd_Thesis_LA.pdf
file_size: 34101468
relation: main_file
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checksum: d8e59afd0817c98fba2564a264508e5c
content_type: application/zip
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date_updated: 2023-12-14T08:58:18Z
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content_type: application/zip
creator: larathoo
date_created: 2023-12-11T19:24:59Z
date_updated: 2023-12-14T08:58:18Z
file_id: '14681'
file_name: Supplementary_Materials.zip
file_size: 10713896
relation: supplementary_material
file_date_updated: 2023-12-14T08:58:18Z
has_accepted_license: '1'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: '96'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '11411'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
title: Investigating inbreeding depression and the self-incompatibility locus of Antirrhinum
majus
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2023'
...
---
_id: '14654'
abstract:
- lang: eng
text: Two assumptions commonly applied in convection schemes—the diagnostic and
quasi-equilibrium assumptions—imply that convective activity (e.g., convective
precipitation) is controlled only by the large-scale (macrostate) environment
at the time. In contrast, numerical experiments indicate a “memory” or dependence
of convection also on its own previous activity whereby subgrid-scale (microstate)
structures boost but are also boosted by convection. In this study we investigated
this memory by comparing single-column model behavior in two idealized tests previously
executed by a cloud-resolving model (CRM). Conventional convection schemes that
employ the diagnostic assumption fail to reproduce the CRM behavior. The memory-capable
org and Laboratoire de Météorologie Dynamique Zoom cold pool schemes partially
capture the behavior, but fail to fully exhibit the strong reinforcing feedbacks
implied by the CRM. Analysis of this failure suggests that it is because the CRM
supports a linear (or superlinear) dependence of the subgrid structure growth
rate on the precipitation rate, while the org scheme assumes a sublinear dependence.
Among varying versions of the org scheme, the growth rate of the org variable
representing subgrid structure is strongly associated with memory strength. These
results demonstrate the importance of parameterizing convective memory, and the
ability of idealized tests to reveal shortcomings of convection schemes and constrain
model structural assumptions.
acknowledgement: YLH is supported by funding from the European Union's Horizon 2020
research and innovation programme under the Marie Skłodowska-Curie Grant Agreement
No. 101034413. CJM gratefully acknowledges funding from the European Research Council
under the European Union's Horizon 2020 research and innovation program (Project
CLUSTER, Grant Agreement No. 805041). YLH and SCS were supported by the Australian
Research Council (FL150100035). The authors thank Brian Mapes, David Fuchs and Siwon
Song for stimulating and helpful discussions. MC warmly thanks the LMD team in Paris
for their assistance with the LMDZ model. We thank the two anonymous reviewers for
their constructive comments that greatly improved this manuscript.
article_number: e2023MS003726
article_processing_charge: Yes
article_type: original
author:
- first_name: Yi-Ling
full_name: Hwong, Yi-Ling
id: 1217aa61-4dd1-11ec-9ac3-f2ba3f17ee22
last_name: Hwong
orcid: 0000-0001-9281-3479
- first_name: M.
full_name: Colin, M.
last_name: Colin
- first_name: Philipp
full_name: Aglas, Philipp
id: 02eace56-97fc-11ee-b81a-f0939ca85a77
last_name: Aglas
- first_name: Caroline J
full_name: Muller, Caroline J
id: f978ccb0-3f7f-11eb-b193-b0e2bd13182b
last_name: Muller
orcid: 0000-0001-5836-5350
- first_name: S. C.
full_name: Sherwood, S. C.
last_name: Sherwood
citation:
ama: Hwong Y-L, Colin M, Aglas P, Muller CJ, Sherwood SC. Assessing memory in convection
schemes using idealized tests. Journal of Advances in Modeling Earth Systems.
2023;15(12). doi:10.1029/2023MS003726
apa: Hwong, Y.-L., Colin, M., Aglas, P., Muller, C. J., & Sherwood, S. C. (2023).
Assessing memory in convection schemes using idealized tests. Journal of Advances
in Modeling Earth Systems. Wiley. https://doi.org/10.1029/2023MS003726
chicago: Hwong, Yi-Ling, M. Colin, Philipp Aglas, Caroline J Muller, and S. C. Sherwood.
“Assessing Memory in Convection Schemes Using Idealized Tests.” Journal of
Advances in Modeling Earth Systems. Wiley, 2023. https://doi.org/10.1029/2023MS003726.
ieee: Y.-L. Hwong, M. Colin, P. Aglas, C. J. Muller, and S. C. Sherwood, “Assessing
memory in convection schemes using idealized tests,” Journal of Advances in
Modeling Earth Systems, vol. 15, no. 12. Wiley, 2023.
ista: Hwong Y-L, Colin M, Aglas P, Muller CJ, Sherwood SC. 2023. Assessing memory
in convection schemes using idealized tests. Journal of Advances in Modeling Earth
Systems. 15(12), e2023MS003726.
mla: Hwong, Yi-Ling, et al. “Assessing Memory in Convection Schemes Using Idealized
Tests.” Journal of Advances in Modeling Earth Systems, vol. 15, no. 12,
e2023MS003726, Wiley, 2023, doi:10.1029/2023MS003726.
short: Y.-L. Hwong, M. Colin, P. Aglas, C.J. Muller, S.C. Sherwood, Journal of Advances
in Modeling Earth Systems 15 (2023).
corr_author: '1'
date_created: 2023-12-10T23:00:57Z
date_published: 2023-12-01T00:00:00Z
date_updated: 2025-09-09T13:35:40Z
day: '01'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1029/2023MS003726
ec_funded: 1
external_id:
isi:
- '001110801100001'
file:
- access_level: open_access
checksum: 4d060b293da3d203de8769e398edf711
content_type: application/pdf
creator: dernst
date_created: 2023-12-11T08:08:44Z
date_updated: 2023-12-11T08:08:44Z
file_id: '14670'
file_name: 2023_JAMES_Hwong.pdf
file_size: 2783677
relation: main_file
success: 1
file_date_updated: 2023-12-11T08:08:44Z
has_accepted_license: '1'
intvolume: ' 15'
isi: 1
issue: '12'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 629205d8-2b32-11ec-9570-e1356ff73576
call_identifier: H2020
grant_number: '805041'
name: Organization of CLoUdS, and implications of Tropical cyclones and for the
Energetics of the tropics, in current and waRming climate
publication: Journal of Advances in Modeling Earth Systems
publication_identifier:
eissn:
- 1942-2466
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '14991'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Assessing memory in convection schemes using idealized tests
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 15
year: '2023'
...
---
_id: '14655'
abstract:
- lang: eng
text: The kinetics of the assembly of semiflexible filaments through end-to-end
annealing is key to the structure of the cytoskeleton, but is not understood.
We analyze this problem through scaling theory and simulations, and uncover a
regime where filaments’ ends find each other through bending fluctuations without
the need for the whole filament to diffuse. This results in a very substantial
speedup of assembly in physiological regimes, and could help with understanding
the dynamics of actin and intermediate filaments in biological processes such
as wound healing and cell division.
acknowledgement: The authors thank C´ecile Leduc and Duc-Quang Tran for invaluable
help with understanding the experimental behavior of intermediate filaments, and
Raphael Voituriez, Nicolas Levernier, and Alexander Grosberg for fruitful discussion
on the theoretical model. V. S. also thanks Davide Michieletto, Maria Panoukidou,
and Lorenzo Rovigatti for very helpful suggestions on the simulation model. M. L.
was supported by Marie Curie Integration Grant No. PCIG12-GA-2012-334053, “Investissements
d’Avenir” LabEx PALM (ANR-10-LABX- 0039-PALM), ANR Grants No. ANR-15-CE13-0004-03,
No. ANR-21-CE11-0004-02 and No. ANR-22-CE30-0024, as well as ERC Starting Grant
No. 677532. M.L.’s group belongs to the CNRS consortium AQV. Part of this work was
performed using HPC resources from GENCI–IDRIS (Grants No. 2020-A0090712066 and
No. 2021-A0110712066).
article_number: '228401'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Valerio
full_name: Sorichetti, Valerio
id: ef8a92cb-c7b6-11ec-8bea-e1fd5847bc5b
last_name: Sorichetti
orcid: 0000-0002-9645-6576
- first_name: Martin
full_name: Lenz, Martin
last_name: Lenz
citation:
ama: Sorichetti V, Lenz M. Transverse fluctuations control the assembly of semiflexible
filaments. Physical Review Letters. 2023;131(22). doi:10.1103/PhysRevLett.131.228401
apa: Sorichetti, V., & Lenz, M. (2023). Transverse fluctuations control the
assembly of semiflexible filaments. Physical Review Letters. American Physical
Society. https://doi.org/10.1103/PhysRevLett.131.228401
chicago: Sorichetti, Valerio, and Martin Lenz. “Transverse Fluctuations Control
the Assembly of Semiflexible Filaments.” Physical Review Letters. American
Physical Society, 2023. https://doi.org/10.1103/PhysRevLett.131.228401.
ieee: V. Sorichetti and M. Lenz, “Transverse fluctuations control the assembly of
semiflexible filaments,” Physical Review Letters, vol. 131, no. 22. American
Physical Society, 2023.
ista: Sorichetti V, Lenz M. 2023. Transverse fluctuations control the assembly of
semiflexible filaments. Physical Review Letters. 131(22), 228401.
mla: Sorichetti, Valerio, and Martin Lenz. “Transverse Fluctuations Control the
Assembly of Semiflexible Filaments.” Physical Review Letters, vol. 131,
no. 22, 228401, American Physical Society, 2023, doi:10.1103/PhysRevLett.131.228401.
short: V. Sorichetti, M. Lenz, Physical Review Letters 131 (2023).
corr_author: '1'
date_created: 2023-12-10T23:00:57Z
date_published: 2023-12-01T00:00:00Z
date_updated: 2025-09-09T13:35:06Z
day: '01'
department:
- _id: AnSa
doi: 10.1103/PhysRevLett.131.228401
external_id:
arxiv:
- '2303.03088'
isi:
- '001163810200008'
pmid:
- '38101392'
intvolume: ' 131'
isi: 1
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2303.03088
month: '12'
oa: 1
oa_version: Preprint
pmid: 1
publication: Physical Review Letters
publication_identifier:
eissn:
- 1079-7114
issn:
- 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Transverse fluctuations control the assembly of semiflexible filaments
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 131
year: '2023'
...
---
_id: '14656'
abstract:
- lang: eng
text: Although much is known about how single neurons in the hippocampus represent
an animal's position, how circuit interactions contribute to spatial coding is
less well understood. Using a novel statistical estimator and theoretical modeling,
both developed in the framework of maximum entropy models, we reveal highly structured
CA1 cell-cell interactions in male rats during open field exploration. The statistics
of these interactions depend on whether the animal is in a familiar or novel environment.
In both conditions the circuit interactions optimize the encoding of spatial information,
but for regimes that differ in the informativeness of their spatial inputs. This
structure facilitates linear decodability, making the information easy to read
out by downstream circuits. Overall, our findings suggest that the efficient coding
hypothesis is not only applicable to individual neuron properties in the sensory
periphery, but also to neural interactions in the central brain.
acknowledgement: M.N. was supported by the European Union Horizon 2020 Grant 665385.
J.C. was supported by the European Research Council Consolidator Grant 281511. G.T.
was supported by the Austrian Science Fund (FWF) Grant P34015. C.S. was supported
by an Institute of Science and Technology fellow award and by the National Science
Foundation (NSF) Award No. 1922658. We thank Peter Baracskay, Karola Kaefer, and
Hugo Malagon-Vina for the acquisition of the data. We also thank Federico Stella,
Wiktor Młynarski, Dori Derdikman, Colin Bredenberg, Roman Huszar, Heloisa Chiossi,
Lorenzo Posani, and Mohamady El-Gaby for comments on an earlier version of the manuscript.
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Michele
full_name: Nardin, Michele
id: 30BD0376-F248-11E8-B48F-1D18A9856A87
last_name: Nardin
orcid: 0000-0001-8849-6570
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
- first_name: Cristina
full_name: Savin, Cristina
id: 3933349E-F248-11E8-B48F-1D18A9856A87
last_name: Savin
citation:
ama: Nardin M, Csicsvari JL, Tkačik G, Savin C. The structure of hippocampal CA1
interactions optimizes spatial coding across experience. The Journal of Neuroscience.
2023;43(48):8140-8156. doi:10.1523/JNEUROSCI.0194-23.2023
apa: Nardin, M., Csicsvari, J. L., Tkačik, G., & Savin, C. (2023). The structure
of hippocampal CA1 interactions optimizes spatial coding across experience. The
Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.0194-23.2023
chicago: Nardin, Michele, Jozsef L Csicsvari, Gašper Tkačik, and Cristina Savin.
“The Structure of Hippocampal CA1 Interactions Optimizes Spatial Coding across
Experience.” The Journal of Neuroscience. Society for Neuroscience, 2023.
https://doi.org/10.1523/JNEUROSCI.0194-23.2023.
ieee: M. Nardin, J. L. Csicsvari, G. Tkačik, and C. Savin, “The structure of hippocampal
CA1 interactions optimizes spatial coding across experience,” The Journal of
Neuroscience, vol. 43, no. 48. Society for Neuroscience, pp. 8140–8156, 2023.
ista: Nardin M, Csicsvari JL, Tkačik G, Savin C. 2023. The structure of hippocampal
CA1 interactions optimizes spatial coding across experience. The Journal of Neuroscience.
43(48), 8140–8156.
mla: Nardin, Michele, et al. “The Structure of Hippocampal CA1 Interactions Optimizes
Spatial Coding across Experience.” The Journal of Neuroscience, vol. 43,
no. 48, Society for Neuroscience, 2023, pp. 8140–56, doi:10.1523/JNEUROSCI.0194-23.2023.
short: M. Nardin, J.L. Csicsvari, G. Tkačik, C. Savin, The Journal of Neuroscience
43 (2023) 8140–8156.
date_created: 2023-12-10T23:00:58Z
date_published: 2023-11-29T00:00:00Z
date_updated: 2025-09-09T13:37:51Z
day: '29'
ddc:
- '570'
department:
- _id: JoCs
- _id: GaTk
doi: 10.1523/JNEUROSCI.0194-23.2023
ec_funded: 1
external_id:
isi:
- '001148071000005'
pmid:
- '37758476'
file:
- access_level: open_access
checksum: e2503c8f84be1050e28f64320f1d5bd2
content_type: application/pdf
creator: dernst
date_created: 2023-12-11T11:30:37Z
date_updated: 2024-06-02T22:30:03Z
embargo: 2024-06-01
file_id: '14674'
file_name: 2023_JourNeuroscience_Nardin.pdf
file_size: 2280632
relation: main_file
file_date_updated: 2024-06-02T22:30:03Z
has_accepted_license: '1'
intvolume: ' 43'
isi: 1
issue: '48'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 8140-8156
pmid: 1
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
- _id: 626c45b5-2b32-11ec-9570-e509828c1ba6
grant_number: P34015
name: Efficient coding with biophysical realism
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: The Journal of Neuroscience
publication_identifier:
eissn:
- 1529-2401
publication_status: published
publisher: Society for Neuroscience
quality_controlled: '1'
related_material:
record:
- id: '10077'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: The structure of hippocampal CA1 interactions optimizes spatial coding across
experience
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 43
year: '2023'
...
---
_id: '14657'
abstract:
- lang: eng
text: 'Natural selection is usually studied between mutants that differ in reproductive
rate, but are subject to the same population structure. Here we explore how natural
selection acts on mutants that have the same reproductive rate, but different
population structures. In our framework, population structure is given by a graph
that specifies where offspring can disperse. The invading mutant disperses offspring
on a different graph than the resident wild-type. We find that more densely connected
dispersal graphs tend to increase the invader’s fixation probability, but the
exact relationship between structure and fixation probability is subtle. We present
three main results. First, we prove that if both invader and resident are on complete
dispersal graphs, then removing a single edge in the invader’s dispersal graph
reduces its fixation probability. Second, we show that for certain island models
higher invader’s connectivity increases its fixation probability, but the magnitude
of the effect depends on the exact layout of the connections. Third, we show that
for lattices the effect of different connectivity is comparable to that of different
fitness: for large population size, the invader’s fixation probability is either
constant or exponentially small, depending on whether it is more or less connected
than the resident.'
acknowledgement: K.C. acknowledges support from the ERC CoG 863818(ForM-SMArt). J.T.
is supported by Center for Foundations ofModern Computer Science (Charles Univ.
project UNCE/SCI/004).
article_number: '20230355'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Josef
full_name: Tkadlec, Josef
id: 3F24CCC8-F248-11E8-B48F-1D18A9856A87
last_name: Tkadlec
orcid: 0000-0002-1097-9684
- first_name: Kamran
full_name: Kaveh, Kamran
last_name: Kaveh
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin A.
full_name: Nowak, Martin A.
last_name: Nowak
citation:
ama: Tkadlec J, Kaveh K, Chatterjee K, Nowak MA. Evolutionary dynamics of mutants
that modify population structure. Journal of the Royal Society, Interface.
2023;20(208). doi:10.1098/rsif.2023.0355
apa: Tkadlec, J., Kaveh, K., Chatterjee, K., & Nowak, M. A. (2023). Evolutionary
dynamics of mutants that modify population structure. Journal of the Royal
Society, Interface. The Royal Society. https://doi.org/10.1098/rsif.2023.0355
chicago: Tkadlec, Josef, Kamran Kaveh, Krishnendu Chatterjee, and Martin A. Nowak.
“Evolutionary Dynamics of Mutants That Modify Population Structure.” Journal
of the Royal Society, Interface. The Royal Society, 2023. https://doi.org/10.1098/rsif.2023.0355.
ieee: J. Tkadlec, K. Kaveh, K. Chatterjee, and M. A. Nowak, “Evolutionary dynamics
of mutants that modify population structure,” Journal of the Royal Society,
Interface, vol. 20, no. 208. The Royal Society, 2023.
ista: Tkadlec J, Kaveh K, Chatterjee K, Nowak MA. 2023. Evolutionary dynamics of
mutants that modify population structure. Journal of the Royal Society, Interface.
20(208), 20230355.
mla: Tkadlec, Josef, et al. “Evolutionary Dynamics of Mutants That Modify Population
Structure.” Journal of the Royal Society, Interface, vol. 20, no. 208,
20230355, The Royal Society, 2023, doi:10.1098/rsif.2023.0355.
short: J. Tkadlec, K. Kaveh, K. Chatterjee, M.A. Nowak, Journal of the Royal Society,
Interface 20 (2023).
date_created: 2023-12-10T23:00:58Z
date_published: 2023-11-29T00:00:00Z
date_updated: 2025-09-09T13:37:01Z
day: '29'
ddc:
- '000'
- '570'
department:
- _id: KrCh
doi: 10.1098/rsif.2023.0355
ec_funded: 1
external_id:
isi:
- '001124419300002'
pmid:
- '38016637'
file:
- access_level: open_access
checksum: 2eefab13127c7786dbd33303c482a004
content_type: application/pdf
creator: dernst
date_created: 2023-12-11T11:10:32Z
date_updated: 2023-12-11T11:10:32Z
file_id: '14673'
file_name: 2023_RoyalInterface_Tkadlec.pdf
file_size: 1720243
relation: main_file
success: 1
file_date_updated: 2023-12-11T11:10:32Z
has_accepted_license: '1'
intvolume: ' 20'
isi: 1
issue: '208'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '863818'
name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
publication: Journal of the Royal Society, Interface
publication_identifier:
eissn:
- 1742-5662
publication_status: published
publisher: The Royal Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Evolutionary dynamics of mutants that modify population structure
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 20
year: '2023'
...
---
_id: '14658'
abstract:
- lang: eng
text: "We investigate spin-charge separation of a spin-\r\n1\r\n2\r\n Fermi system
confined in a triple well where multiple bands are occupied. We assume that our
finite fermionic system is close to fully spin polarized while being doped by
a hole and an impurity fermion with opposite spin. Our setup involves ferromagnetic
couplings among the particles in different bands, leading to the development of
strong spin-transport correlations in an intermediate interaction regime. Interactions
are then strong enough to lift the degeneracy among singlet and triplet spin configurations
in the well of the spin impurity but not strong enough to prohibit hole-induced
magnetic excitations to the singlet state. Despite the strong spin-hole correlations,
the system exhibits spin-charge deconfinement allowing for long-range entanglement
of the spatial and spin degrees of freedom."
acknowledgement: This work has been funded by the Cluster of Excellence “Advanced
Imaging of Matter” of the Deutsche Forschungsgemeinschaft (DFG)-EXC 2056-Project
ID No. 390715994. G.M.K. gratefully acknowledges funding from the European Union’s
Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie
Grant Agreement No. 101034413.
article_number: '043039'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: J. M.
full_name: Becker, J. M.
last_name: Becker
- first_name: Georgios
full_name: Koutentakis, Georgios
id: d7b23d3a-9e21-11ec-b482-f76739596b95
last_name: Koutentakis
- first_name: P.
full_name: Schmelcher, P.
last_name: Schmelcher
citation:
ama: Becker JM, Koutentakis G, Schmelcher P. Spin-charge correlations in finite
one-dimensional multiband Fermi systems. Physical Review Research. 2023;5(4).
doi:10.1103/PhysRevResearch.5.043039
apa: Becker, J. M., Koutentakis, G., & Schmelcher, P. (2023). Spin-charge correlations
in finite one-dimensional multiband Fermi systems. Physical Review Research.
American Physical Society. https://doi.org/10.1103/PhysRevResearch.5.043039
chicago: Becker, J. M., Georgios Koutentakis, and P. Schmelcher. “Spin-Charge Correlations
in Finite One-Dimensional Multiband Fermi Systems.” Physical Review Research.
American Physical Society, 2023. https://doi.org/10.1103/PhysRevResearch.5.043039.
ieee: J. M. Becker, G. Koutentakis, and P. Schmelcher, “Spin-charge correlations
in finite one-dimensional multiband Fermi systems,” Physical Review Research,
vol. 5, no. 4. American Physical Society, 2023.
ista: Becker JM, Koutentakis G, Schmelcher P. 2023. Spin-charge correlations in
finite one-dimensional multiband Fermi systems. Physical Review Research. 5(4),
043039.
mla: Becker, J. M., et al. “Spin-Charge Correlations in Finite One-Dimensional Multiband
Fermi Systems.” Physical Review Research, vol. 5, no. 4, 043039, American
Physical Society, 2023, doi:10.1103/PhysRevResearch.5.043039.
short: J.M. Becker, G. Koutentakis, P. Schmelcher, Physical Review Research 5 (2023).
corr_author: '1'
date_created: 2023-12-10T23:00:58Z
date_published: 2023-10-12T00:00:00Z
date_updated: 2025-04-14T07:54:54Z
day: '12'
ddc:
- '530'
department:
- _id: MiLe
doi: 10.1103/PhysRevResearch.5.043039
ec_funded: 1
external_id:
arxiv:
- '2305.09529'
file:
- access_level: open_access
checksum: ee31c0d0de5d1b65591990ae6705a601
content_type: application/pdf
creator: dernst
date_created: 2023-12-11T10:49:07Z
date_updated: 2023-12-11T10:49:07Z
file_id: '14672'
file_name: 2023_PhysReviewResearch_Becker.pdf
file_size: 2362158
relation: main_file
success: 1
file_date_updated: 2023-12-11T10:49:07Z
has_accepted_license: '1'
intvolume: ' 5'
issue: '4'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: Physical Review Research
publication_identifier:
issn:
- 2643-1564
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Spin-charge correlations in finite one-dimensional multiband Fermi systems
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2023'
...
---
APC_amount: 4800 EUR
OA_place: publisher
OA_type: hybrid
_id: '14659'
abstract:
- lang: eng
text: Understanding the response of Himalayan glaciers to global warming is vital
because of their role as a water source for the Asian subcontinent. However, great
uncertainties still exist on the climate drivers of past and present glacier changes
across scales. Here, we analyse continuous hourly climate station data from a
glacierized elevation (Pyramid station, Mount Everest) since 1994 together with
other ground observations and climate reanalysis. We show that a decrease in maximum
air temperature and precipitation occurred during the last three decades at Pyramid
in response to global warming. Reanalysis data suggest a broader occurrence of
this effect in the glacierized areas of the Himalaya. We hypothesize that the
counterintuitive cooling is caused by enhanced sensible heat exchange and the
associated increase in glacier katabatic wind, which draws cool air downward from
higher elevations. The stronger katabatic winds have also lowered the elevation
of local wind convergence, thereby diminishing precipitation in glacial areas
and negatively affecting glacier mass balance. This local cooling may have partially
preserved glaciers from melting and could help protect the periglacial environment.
acknowledgement: This work was carried out within the framework of the EV-K2-CNR and
Nepal Academy of Science and Technology. K.Y. was supported by the Second Tibetan
Plateau Scientific Expedition and Research Program (grant no. 2019QZKK0206). N.C.
was supported by the project NODES, which has received funding from the MUR–M4C2
1.5 of PNRR funded by the European Union - NextGeneration EU (Grant agreement no.
ECS00000036). T.E.S. has received funding from the European Union’s Horizon 2020
research and innovation programme under the Marie Sklodowska-Curie grant no. 101026058.
F.P. has received funding from the European Research Council under the European
Union’s Horizon 2020 research and innovation programme grant no. 772751, RAVEN,
‘Rapid mass losses of debris-covered glaciers in High Mountain Asia’ and has been
supported by the SNSF grant ‘High-elevation precipitation in High Mountain Asia’
(grant no. 183633). A.A. was supported by the European Union’s Horizon 2020 research
and innovation program under grant agreement no. 101004156 (CONFESS project) and
by the European Union’s Horizon Europe research and innovation program under grant
agreement no. 101081193 (OptimESM project). We thank H. Wehrli for valuable comments
and suggestions and J. Giannitrapani for the graphic support. We thank A. Da Polenza
and K. Bista of EV-K2-CNR for believing that studying the high elevations is relevant
for the whole globe.
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Franco
full_name: Salerno, Franco
last_name: Salerno
- first_name: Nicolas
full_name: Guyennon, Nicolas
last_name: Guyennon
- first_name: Kun
full_name: Yang, Kun
last_name: Yang
- first_name: Thomas
full_name: Shaw, Thomas
id: 3caa3f91-1f03-11ee-96ce-e0e553054d6e
last_name: Shaw
orcid: 0000-0001-7640-6152
- first_name: Changgui
full_name: Lin, Changgui
last_name: Lin
- first_name: Nicola
full_name: Colombo, Nicola
last_name: Colombo
- first_name: Emanuele
full_name: Romano, Emanuele
last_name: Romano
- first_name: Stephan
full_name: Gruber, Stephan
last_name: Gruber
- first_name: Tobias
full_name: Bolch, Tobias
last_name: Bolch
- first_name: Andrea
full_name: Alessandri, Andrea
last_name: Alessandri
- first_name: Paolo
full_name: Cristofanelli, Paolo
last_name: Cristofanelli
- first_name: Davide
full_name: Putero, Davide
last_name: Putero
- first_name: Guglielmina
full_name: Diolaiuti, Guglielmina
last_name: Diolaiuti
- first_name: Gianni
full_name: Tartari, Gianni
last_name: Tartari
- first_name: Gianpietro
full_name: Verza, Gianpietro
last_name: Verza
- first_name: Sudeep
full_name: Thakuri, Sudeep
last_name: Thakuri
- first_name: Gianpaolo
full_name: Balsamo, Gianpaolo
last_name: Balsamo
- first_name: Evan S.
full_name: Miles, Evan S.
last_name: Miles
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
orcid: 0000-0002-5554-8087
citation:
ama: Salerno F, Guyennon N, Yang K, et al. Local cooling and drying induced by Himalayan
glaciers under global warming. Nature Geoscience. 2023;16:1120-1127. doi:10.1038/s41561-023-01331-y
apa: Salerno, F., Guyennon, N., Yang, K., Shaw, T., Lin, C., Colombo, N., … Pellicciotti,
F. (2023). Local cooling and drying induced by Himalayan glaciers under global
warming. Nature Geoscience. Springer Nature. https://doi.org/10.1038/s41561-023-01331-y
chicago: Salerno, Franco, Nicolas Guyennon, Kun Yang, Thomas Shaw, Changgui Lin,
Nicola Colombo, Emanuele Romano, et al. “Local Cooling and Drying Induced by Himalayan
Glaciers under Global Warming.” Nature Geoscience. Springer Nature, 2023.
https://doi.org/10.1038/s41561-023-01331-y.
ieee: F. Salerno et al., “Local cooling and drying induced by Himalayan glaciers
under global warming,” Nature Geoscience, vol. 16. Springer Nature, pp.
1120–1127, 2023.
ista: Salerno F, Guyennon N, Yang K, Shaw T, Lin C, Colombo N, Romano E, Gruber
S, Bolch T, Alessandri A, Cristofanelli P, Putero D, Diolaiuti G, Tartari G, Verza
G, Thakuri S, Balsamo G, Miles ES, Pellicciotti F. 2023. Local cooling and drying
induced by Himalayan glaciers under global warming. Nature Geoscience. 16, 1120–1127.
mla: Salerno, Franco, et al. “Local Cooling and Drying Induced by Himalayan Glaciers
under Global Warming.” Nature Geoscience, vol. 16, Springer Nature, 2023,
pp. 1120–27, doi:10.1038/s41561-023-01331-y.
short: F. Salerno, N. Guyennon, K. Yang, T. Shaw, C. Lin, N. Colombo, E. Romano,
S. Gruber, T. Bolch, A. Alessandri, P. Cristofanelli, D. Putero, G. Diolaiuti,
G. Tartari, G. Verza, S. Thakuri, G. Balsamo, E.S. Miles, F. Pellicciotti, Nature
Geoscience 16 (2023) 1120–1127.
date_created: 2023-12-10T23:00:58Z
date_published: 2023-12-04T00:00:00Z
date_updated: 2025-09-09T13:36:16Z
day: '04'
ddc:
- '550'
department:
- _id: FrPe
doi: 10.1038/s41561-023-01331-y
external_id:
isi:
- '001112839700003'
file:
- access_level: open_access
checksum: d5ae0d17069eebc6f454c8608cf83e21
content_type: application/pdf
creator: dernst
date_created: 2023-12-11T10:11:19Z
date_updated: 2023-12-11T10:11:19Z
file_id: '14671'
file_name: 2023_NatureGeoscience_Salerno.pdf
file_size: 6072603
relation: main_file
success: 1
file_date_updated: 2023-12-11T10:11:19Z
has_accepted_license: '1'
intvolume: ' 16'
isi: 1
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 1120-1127
publication: Nature Geoscience
publication_identifier:
eissn:
- 1752-0908
issn:
- 1752-0894
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/wind-of-climate-change/
scopus_import: '1'
status: public
title: Local cooling and drying induced by Himalayan glaciers under global warming
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 16
year: '2023'
...
---
_id: '14661'
abstract:
- lang: eng
text: 'This paper is concerned with equilibrium configurations of one-dimensional
particle systems with non-convex nearest-neighbour and next-to-nearest-neighbour
interactions and its passage to the continuum. The goal is to derive compactness
results for a Γ-development of the energy with the novelty that external forces
are allowed. In particular, the forces may depend on Lagrangian or Eulerian coordinates
and thus may model dead as well as live loads. Our result is based on a new technique
for deriving compactness results which are required for calculating the first-order
Γ-limit in the presence of external forces: instead of comparing a configuration
of n atoms to a global minimizer of the Γ-limit, we compare the configuration
to a minimizer in some subclass of functions which in some sense are "close to"
the configuration. The paper is complemented with the study of the minimizers
of the Γ-limit.'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Marcello
full_name: Carioni, Marcello
last_name: Carioni
- first_name: Julian L
full_name: Fischer, Julian L
id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
last_name: Fischer
orcid: 0000-0002-0479-558X
- first_name: Anja
full_name: Schlömerkemper, Anja
last_name: Schlömerkemper
citation:
ama: 'Carioni M, Fischer JL, Schlömerkemper A. External forces in the continuum
limit of discrete systems with non-convex interaction potentials: Compactness
for a Γ-development. Journal of Convex Analysis. 2023;30(1):217-247.'
apa: 'Carioni, M., Fischer, J. L., & Schlömerkemper, A. (2023). External forces
in the continuum limit of discrete systems with non-convex interaction potentials:
Compactness for a Γ-development. Journal of Convex Analysis. Heldermann
Verlag.'
chicago: 'Carioni, Marcello, Julian L Fischer, and Anja Schlömerkemper. “External
Forces in the Continuum Limit of Discrete Systems with Non-Convex Interaction
Potentials: Compactness for a Γ-Development.” Journal of Convex Analysis.
Heldermann Verlag, 2023.'
ieee: 'M. Carioni, J. L. Fischer, and A. Schlömerkemper, “External forces in the
continuum limit of discrete systems with non-convex interaction potentials: Compactness
for a Γ-development,” Journal of Convex Analysis, vol. 30, no. 1. Heldermann
Verlag, pp. 217–247, 2023.'
ista: 'Carioni M, Fischer JL, Schlömerkemper A. 2023. External forces in the continuum
limit of discrete systems with non-convex interaction potentials: Compactness
for a Γ-development. Journal of Convex Analysis. 30(1), 217–247.'
mla: 'Carioni, Marcello, et al. “External Forces in the Continuum Limit of Discrete
Systems with Non-Convex Interaction Potentials: Compactness for a Γ-Development.”
Journal of Convex Analysis, vol. 30, no. 1, Heldermann Verlag, 2023, pp.
217–47.'
short: M. Carioni, J.L. Fischer, A. Schlömerkemper, Journal of Convex Analysis 30
(2023) 217–247.
corr_author: '1'
date_created: 2023-12-10T23:00:59Z
date_published: 2023-01-01T00:00:00Z
date_updated: 2024-10-09T21:07:35Z
day: '01'
department:
- _id: JuFi
external_id:
arxiv:
- '1811.09857'
isi:
- '001115503400013'
intvolume: ' 30'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1811.09857
month: '01'
oa: 1
oa_version: Preprint
page: 217-247
publication: Journal of Convex Analysis
publication_identifier:
eissn:
- 2363-6394
issn:
- 0944-6532
publication_status: published
publisher: Heldermann Verlag
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'External forces in the continuum limit of discrete systems with non-convex
interaction potentials: Compactness for a Γ-development'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 30
year: '2023'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: diamond
_id: '14662'
abstract:
- lang: eng
text: We consider a class of polaron models, including the Fröhlich model, at zero
total momentum, and show that at sufficiently weak coupling there are no excited
eigenvalues below the essential spectrum.
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Seiringer R. Absence of excited eigenvalues for Fröhlich type polaron models
at weak coupling. Journal of Spectral Theory. 2023;13(3):1045-1055. doi:10.4171/JST/469
apa: Seiringer, R. (2023). Absence of excited eigenvalues for Fröhlich type polaron
models at weak coupling. Journal of Spectral Theory. EMS Press. https://doi.org/10.4171/JST/469
chicago: Seiringer, Robert. “Absence of Excited Eigenvalues for Fröhlich Type Polaron
Models at Weak Coupling.” Journal of Spectral Theory. EMS Press, 2023.
https://doi.org/10.4171/JST/469.
ieee: R. Seiringer, “Absence of excited eigenvalues for Fröhlich type polaron models
at weak coupling,” Journal of Spectral Theory, vol. 13, no. 3. EMS Press,
pp. 1045–1055, 2023.
ista: Seiringer R. 2023. Absence of excited eigenvalues for Fröhlich type polaron
models at weak coupling. Journal of Spectral Theory. 13(3), 1045–1055.
mla: Seiringer, Robert. “Absence of Excited Eigenvalues for Fröhlich Type Polaron
Models at Weak Coupling.” Journal of Spectral Theory, vol. 13, no. 3, EMS
Press, 2023, pp. 1045–55, doi:10.4171/JST/469.
short: R. Seiringer, Journal of Spectral Theory 13 (2023) 1045–1055.
corr_author: '1'
date_created: 2023-12-10T23:00:59Z
date_published: 2023-11-25T00:00:00Z
date_updated: 2025-09-09T13:40:33Z
day: '25'
ddc:
- '510'
department:
- _id: RoSe
doi: 10.4171/JST/469
external_id:
arxiv:
- '2210.17123'
isi:
- '001127467700008'
file:
- access_level: open_access
checksum: 9ce96ca87d56ea9a70d2eb9a32839f8d
content_type: application/pdf
creator: dernst
date_created: 2023-12-11T12:03:12Z
date_updated: 2023-12-11T12:03:12Z
file_id: '14677'
file_name: 2023_JST_Seiringer.pdf
file_size: 201513
relation: main_file
success: 1
file_date_updated: 2023-12-11T12:03:12Z
has_accepted_license: '1'
intvolume: ' 13'
isi: 1
issue: '3'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 1045-1055
publication: Journal of Spectral Theory
publication_identifier:
eissn:
- 1664-0403
issn:
- 1664-039X
publication_status: published
publisher: EMS Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Absence of excited eigenvalues for Fröhlich type polaron models at weak coupling
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 13
year: '2023'
...
---
_id: '14663'
abstract:
- lang: eng
text: As a bottleneck in the direct synthesis of hydrogen peroxide, the development
of an efficient palladium-based catalyst has garnered great attention. However,
elusive active centers and reaction mechanism issues inhibit further optimization
of its performance. In this work, advanced microkinetic modeling with the adsorbate–adsorbate
interaction and nanoparticle size effect based on first-principles calculations
is developed. A full mechanism uncovering the significance of adsorbate–adsorbate
interaction is determined on Pd nanoparticles. We demonstrate unambiguously that
Pd(100) with main coverage species of O2 and H is beneficial to H2O2 production,
being consistent with experimental operando observation, while H2O forms on Pd(111)
covered by O species and Pd(211) covered by O and OH species. Kinetic analyses
further enable quantitative estimation of the influence of temperature, pressure,
and particle size. Large-size Pd nanoparticles are found to achieve a high H2O2
reaction rate when the operating conditions are moderate temperature and higher
oxygen partial pressure. We reveal that specific facets of the Pd nanoparticles
are crucial factors for their selectivity and activity. Consistent with the experiment,
the production of H2O2 is discovered to be more favorable on Pd nanoparticles
containing Pd(100) facets. The ratio of H2/O2 induces substantial variations in
the coverage of intermediates of O2 and H on Pd(100), resulting in a change in
product selectivity.
acknowledgement: The authors acknowledge the financial support from the National Natural
Science Foundation of China (22008211, 92045303, U21A20298), the National Key Research
and Development Project of China (2021YFA1500900, 2022YFE0113800), and Zhejiang
Innovation Team (2017R5203).
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Jinyan
full_name: Zhao, Jinyan
last_name: Zhao
- first_name: Zihao
full_name: Yao, Zihao
last_name: Yao
- first_name: Rhys
full_name: Bunting, Rhys
id: 91deeae8-1207-11ec-b130-c194ad5b50c6
last_name: Bunting
orcid: 0000-0001-6928-074X
- first_name: P.
full_name: Hu, P.
last_name: Hu
- first_name: Jianguo
full_name: Wang, Jianguo
last_name: Wang
citation:
ama: Zhao J, Yao Z, Bunting R, Hu P, Wang J. Microkinetic modeling with size-dependent
and adsorbate-adsorbate interactions for the direct synthesis of H₂O₂ over Pd
nanoparticles. ACS Catalysis. 2023;13(22):15054-15073. doi:10.1021/acscatal.3c03893
apa: Zhao, J., Yao, Z., Bunting, R., Hu, P., & Wang, J. (2023). Microkinetic
modeling with size-dependent and adsorbate-adsorbate interactions for the direct
synthesis of H₂O₂ over Pd nanoparticles. ACS Catalysis. American Chemical
Society. https://doi.org/10.1021/acscatal.3c03893
chicago: Zhao, Jinyan, Zihao Yao, Rhys Bunting, P. Hu, and Jianguo Wang. “Microkinetic
Modeling with Size-Dependent and Adsorbate-Adsorbate Interactions for the Direct
Synthesis of H₂O₂ over Pd Nanoparticles.” ACS Catalysis. American Chemical
Society, 2023. https://doi.org/10.1021/acscatal.3c03893.
ieee: J. Zhao, Z. Yao, R. Bunting, P. Hu, and J. Wang, “Microkinetic modeling with
size-dependent and adsorbate-adsorbate interactions for the direct synthesis of
H₂O₂ over Pd nanoparticles,” ACS Catalysis, vol. 13, no. 22. American Chemical
Society, pp. 15054–15073, 2023.
ista: Zhao J, Yao Z, Bunting R, Hu P, Wang J. 2023. Microkinetic modeling with size-dependent
and adsorbate-adsorbate interactions for the direct synthesis of H₂O₂ over Pd
nanoparticles. ACS Catalysis. 13(22), 15054–15073.
mla: Zhao, Jinyan, et al. “Microkinetic Modeling with Size-Dependent and Adsorbate-Adsorbate
Interactions for the Direct Synthesis of H₂O₂ over Pd Nanoparticles.” ACS Catalysis,
vol. 13, no. 22, American Chemical Society, 2023, pp. 15054–73, doi:10.1021/acscatal.3c03893.
short: J. Zhao, Z. Yao, R. Bunting, P. Hu, J. Wang, ACS Catalysis 13 (2023) 15054–15073.
corr_author: '1'
date_created: 2023-12-10T23:00:59Z
date_published: 2023-11-06T00:00:00Z
date_updated: 2025-09-09T13:39:57Z
day: '06'
ddc:
- '540'
department:
- _id: MaIb
doi: 10.1021/acscatal.3c03893
external_id:
isi:
- '001140495600001'
file:
- access_level: open_access
checksum: a97c771077af71ddfb2249e34530895c
content_type: application/pdf
creator: dernst
date_created: 2023-12-11T11:55:09Z
date_updated: 2023-12-11T11:55:09Z
file_id: '14676'
file_name: 2023_ACSCatalysis_.pdf
file_size: 14813812
relation: main_file
success: 1
file_date_updated: 2023-12-11T11:55:09Z
has_accepted_license: '1'
intvolume: ' 13'
isi: 1
issue: '22'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 15054-15073
publication: ACS Catalysis
publication_identifier:
eissn:
- 2155-5435
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Microkinetic modeling with size-dependent and adsorbate-adsorbate interactions
for the direct synthesis of H₂O₂ over Pd nanoparticles
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 13
year: '2023'
...
---
_id: '14664'
abstract:
- lang: eng
text: The architecture of self-assembled host molecules can profoundly affect the
properties of the encapsulated guests. For example, a rigid cage with small windows
can efficiently protect its contents from the environment; in contrast, tube-shaped,
flexible hosts with large openings and an easily accessible cavity are ideally
suited for catalysis. Here, we report a “Janus” nature of a Pd6L4 coordination
host previously reported to exist exclusively as a tube isomer (T). We show that
upon encapsulating various tetrahedrally shaped guests, T can reconfigure into
a cage-shaped host (C) in quantitative yield. Extracting the guest affords empty
C, which is metastable and spontaneously relaxes to T, and the T⇄C interconversion
can be repeated for multiple cycles. Reversible toggling between two vastly different
isomers paves the way toward controlling functional properties of coordination
hosts “on demand”.
acknowledgement: We acknowledge funding from the European Union’s Horizon 2020 Research
and Innovation Program under the European Research Council (grant agreement 820008).We
also thank the Deutsche Forschungsgemeinschaft (DFG) for support through priority
program SPP1807(CL489/3-2) and RESOLV Cluster of Excellence EXC2033 (project number
390677874). A.B.G. acknowledges funding from the Zuckerman STEM Leadership Program.
DFT calculations were carried out using resources provided by the Wrocław Center
for Networking and Supercomputing, grant 329.
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Kuntrapakam
full_name: Hema, Kuntrapakam
last_name: Hema
- first_name: Angela B.
full_name: Grommet, Angela B.
last_name: Grommet
- first_name: Michał J.
full_name: Białek, Michał J.
last_name: Białek
- first_name: Jinhua
full_name: Wang, Jinhua
last_name: Wang
- first_name: Laura
full_name: Schneider, Laura
last_name: Schneider
- first_name: Christoph
full_name: Drechsler, Christoph
last_name: Drechsler
- first_name: Oksana
full_name: Yanshyna, Oksana
last_name: Yanshyna
- first_name: Yael
full_name: Diskin-Posner, Yael
last_name: Diskin-Posner
- first_name: Guido H.
full_name: Clever, Guido H.
last_name: Clever
- first_name: Rafal
full_name: Klajn, Rafal
id: 8e84690e-1e48-11ed-a02b-a1e6fb8bb53b
last_name: Klajn
citation:
ama: Hema K, Grommet AB, Białek MJ, et al. Guest encapsulation alters the thermodynamic
landscape of a coordination host. Journal of the American Chemical Society.
2023;145(45):24755-24764. doi:10.1021/jacs.3c08666
apa: Hema, K., Grommet, A. B., Białek, M. J., Wang, J., Schneider, L., Drechsler,
C., … Klajn, R. (2023). Guest encapsulation alters the thermodynamic landscape
of a coordination host. Journal of the American Chemical Society. American
Chemical Society. https://doi.org/10.1021/jacs.3c08666
chicago: Hema, Kuntrapakam, Angela B. Grommet, Michał J. Białek, Jinhua Wang, Laura
Schneider, Christoph Drechsler, Oksana Yanshyna, Yael Diskin-Posner, Guido H.
Clever, and Rafal Klajn. “Guest Encapsulation Alters the Thermodynamic Landscape
of a Coordination Host.” Journal of the American Chemical Society. American
Chemical Society, 2023. https://doi.org/10.1021/jacs.3c08666.
ieee: K. Hema et al., “Guest encapsulation alters the thermodynamic landscape
of a coordination host,” Journal of the American Chemical Society, vol.
145, no. 45. American Chemical Society, pp. 24755–24764, 2023.
ista: Hema K, Grommet AB, Białek MJ, Wang J, Schneider L, Drechsler C, Yanshyna
O, Diskin-Posner Y, Clever GH, Klajn R. 2023. Guest encapsulation alters the thermodynamic
landscape of a coordination host. Journal of the American Chemical Society. 145(45),
24755–24764.
mla: Hema, Kuntrapakam, et al. “Guest Encapsulation Alters the Thermodynamic Landscape
of a Coordination Host.” Journal of the American Chemical Society, vol.
145, no. 45, American Chemical Society, 2023, pp. 24755–64, doi:10.1021/jacs.3c08666.
short: K. Hema, A.B. Grommet, M.J. Białek, J. Wang, L. Schneider, C. Drechsler,
O. Yanshyna, Y. Diskin-Posner, G.H. Clever, R. Klajn, Journal of the American
Chemical Society 145 (2023) 24755–24764.
corr_author: '1'
date_created: 2023-12-10T23:00:59Z
date_published: 2023-11-02T00:00:00Z
date_updated: 2025-09-09T13:39:03Z
day: '02'
ddc:
- '540'
department:
- _id: RaKl
doi: 10.1021/jacs.3c08666
external_id:
isi:
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publication: Journal of the American Chemical Society
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quality_controlled: '1'
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title: Guest encapsulation alters the thermodynamic landscape of a coordination host
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abstract:
- lang: eng
text: So-called spontaneous activity is a central hallmark of most nervous systems.
Such non-causal firing is contrary to the tenet of spikes as a means of communication,
and its purpose remains unclear. We propose that self-initiated firing can serve
as a release valve to protect neurons from the toxic conditions arising in mitochondria
from lower-than-baseline energy consumption. To demonstrate the viability of our
hypothesis, we built a set of models that incorporate recent experimental results
indicating homeostatic control of metabolic products—Adenosine triphosphate (ATP),
adenosine diphosphate (ADP), and reactive oxygen species (ROS)—by changes in firing.
We explore the relationship of metabolic cost of spiking with its effect on the
temporal patterning of spikes and reproduce experimentally observed changes in
intrinsic firing in the fruitfly dorsal fan-shaped body neuron in a model with
ROS-modulated potassium channels. We also show that metabolic spiking homeostasis
can produce indefinitely sustained avalanche dynamics in cortical circuits. Our
theory can account for key features of neuronal activity observed in many studies
ranging from ion channel function all the way to resting state dynamics. We finish
with a set of experimental predictions that would confirm an integrated, crucial
role for metabolically regulated spiking and firmly link metabolic homeostasis
and neuronal function.
acknowledgement: We thank Prof. C. Nazaret and Prof. J.-P. Mazat for sharing the code
of their mitochondrial model. We also thank G. Miesenböck, E. Marder, L. Abbott,
A. Kempf, P. Hasenhuetl, W. Podlaski, F. Zenke, E. Agnes, P. Bozelos, J. Watson,
B. Confavreux, and G. Christodoulou, and the rest of the Vogels Lab for their feedback.
This work was funded by Wellcome Trust and Royal Society Sir Henry Dale Research
Fellowship (WT100000), a Wellcome Trust Senior Research Fellowship (214316/Z/18/Z),
and a UK Research and Innovation, Biotechnology and Biological Sciences Research
Council grant (UKRI-BBSRC BB/N019512/1).
article_number: e2306525120
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Chaitanya
full_name: Chintaluri, Chaitanya
id: E4EDB536-3485-11EA-98D2-20AF3DDC885E
last_name: Chintaluri
- first_name: Tim P
full_name: Vogels, Tim P
id: CB6FF8D2-008F-11EA-8E08-2637E6697425
last_name: Vogels
orcid: 0000-0003-3295-6181
citation:
ama: Chintaluri C, Vogels TP. Metabolically regulated spiking could serve neuronal
energy homeostasis and protect from reactive oxygen species. Proceedings of
the National Academy of Sciences of the United States of America. 2023;120(48).
doi:10.1073/pnas.2306525120
apa: Chintaluri, C., & Vogels, T. P. (2023). Metabolically regulated spiking
could serve neuronal energy homeostasis and protect from reactive oxygen species.
Proceedings of the National Academy of Sciences of the United States of America.
National Academy of Sciences. https://doi.org/10.1073/pnas.2306525120
chicago: Chintaluri, Chaitanya, and Tim P Vogels. “Metabolically Regulated Spiking
Could Serve Neuronal Energy Homeostasis and Protect from Reactive Oxygen Species.”
Proceedings of the National Academy of Sciences of the United States of America.
National Academy of Sciences, 2023. https://doi.org/10.1073/pnas.2306525120.
ieee: C. Chintaluri and T. P. Vogels, “Metabolically regulated spiking could serve
neuronal energy homeostasis and protect from reactive oxygen species,” Proceedings
of the National Academy of Sciences of the United States of America, vol.
120, no. 48. National Academy of Sciences, 2023.
ista: Chintaluri C, Vogels TP. 2023. Metabolically regulated spiking could serve
neuronal energy homeostasis and protect from reactive oxygen species. Proceedings
of the National Academy of Sciences of the United States of America. 120(48),
e2306525120.
mla: Chintaluri, Chaitanya, and Tim P. Vogels. “Metabolically Regulated Spiking
Could Serve Neuronal Energy Homeostasis and Protect from Reactive Oxygen Species.”
Proceedings of the National Academy of Sciences of the United States of America,
vol. 120, no. 48, e2306525120, National Academy of Sciences, 2023, doi:10.1073/pnas.2306525120.
short: C. Chintaluri, T.P. Vogels, Proceedings of the National Academy of Sciences
of the United States of America 120 (2023).
corr_author: '1'
date_created: 2023-12-10T23:01:00Z
date_published: 2023-11-21T00:00:00Z
date_updated: 2025-09-24T11:16:56Z
day: '21'
ddc:
- '570'
department:
- _id: TiVo
doi: 10.1073/pnas.2306525120
external_id:
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pmid:
- '37988463'
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creator: dernst
date_created: 2023-12-11T12:45:12Z
date_updated: 2023-12-11T12:45:12Z
file_id: '14678'
file_name: 2023_PNAS_Chintaluri.pdf
file_size: 16891602
relation: main_file
success: 1
file_date_updated: 2023-12-11T12:45:12Z
has_accepted_license: '1'
intvolume: ' 120'
isi: 1
issue: '48'
language:
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month: '11'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: c084a126-5a5b-11eb-8a69-d75314a70a87
grant_number: 214316/Z/18/Z
name: What’s in a memory? Spatiotemporal dynamics in strongly coupled recurrent
neuronal networks.
publication: Proceedings of the National Academy of Sciences of the United States
of America
publication_identifier:
eissn:
- 1091-6490
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
related_material:
link:
- relation: software
url: https://github.com/ccluri/metabolic_spiking
scopus_import: '1'
status: public
title: Metabolically regulated spiking could serve neuronal energy homeostasis and
protect from reactive oxygen species
tmp:
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type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 120
year: '2023'
...