---
_id: '12837'
abstract:
- lang: eng
  text: As developing tissues grow in size and undergo morphogenetic changes, their
    material properties may be altered. Such changes result from tension dynamics
    at cell contacts or cellular jamming. Yet, in many cases, the cellular mechanisms
    controlling the physical state of growing tissues are unclear. We found that at
    early developmental stages, the epithelium in the developing mouse spinal cord
    maintains both high junctional tension and high fluidity. This is achieved via
    a mechanism in which interkinetic nuclear movements generate cell area dynamics
    that drive extensive cell rearrangements. Over time, the cell proliferation rate
    declines, effectively solidifying the tissue. Thus, unlike well-studied jamming
    transitions, the solidification uncovered here resembles a glass transition that
    depends on the dynamical stresses generated by proliferation and differentiation.
    Our finding that the fluidity of developing epithelia is linked to interkinetic
    nuclear movements and the dynamics of growth is likely to be relevant to multiple
    developing tissues.
acknowledgement: 'We thank S. Hippenmeyer for the reagents and C. P. Heisenberg, J.
  Briscoe and K. Page for comments on the manuscript. This work was supported by IST
  Austria; the European Research Council under Horizon 2020 research and innovation
  programme grant no. 680037 and Horizon Europe grant 101044579 (A.K.); Austrian Science
  Fund (FWF): F78 (Stem Cell Modulation) (A.K.); ISTFELLOW postdoctoral program (A.S.);
  Narodowe Centrum Nauki, Poland SONATA, 2017/26/D/NZ2/00454 (M.Z.); and the Polish
  National Agency for Academic Exchange (M.Z.).'
article_processing_charge: No
article_type: original
author:
- first_name: Laura
  full_name: Bocanegra, Laura
  id: 4896F754-F248-11E8-B48F-1D18A9856A87
  last_name: Bocanegra
- first_name: Amrita
  full_name: Singh, Amrita
  id: 76250f9f-3a21-11eb-9a80-a6180a0d7958
  last_name: Singh
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Marcin P
  full_name: Zagórski, Marcin P
  id: 343DA0DC-F248-11E8-B48F-1D18A9856A87
  last_name: Zagórski
  orcid: 0000-0001-7896-7762
- first_name: Anna
  full_name: Kicheva, Anna
  id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
  last_name: Kicheva
  orcid: 0000-0003-4509-4998
citation:
  ama: Bocanegra L, Singh A, Hannezo EB, Zagórski MP, Kicheva A. Cell cycle dynamics
    control fluidity of the developing mouse neuroepithelium. <i>Nature Physics</i>.
    2023;19:1050-1058. doi:<a href="https://doi.org/10.1038/s41567-023-01977-w">10.1038/s41567-023-01977-w</a>
  apa: Bocanegra, L., Singh, A., Hannezo, E. B., Zagórski, M. P., &#38; Kicheva, A.
    (2023). Cell cycle dynamics control fluidity of the developing mouse neuroepithelium.
    <i>Nature Physics</i>. Springer Nature. <a href="https://doi.org/10.1038/s41567-023-01977-w">https://doi.org/10.1038/s41567-023-01977-w</a>
  chicago: Bocanegra, Laura, Amrita Singh, Edouard B Hannezo, Marcin P Zagórski, and
    Anna Kicheva. “Cell Cycle Dynamics Control Fluidity of the Developing Mouse Neuroepithelium.”
    <i>Nature Physics</i>. Springer Nature, 2023. <a href="https://doi.org/10.1038/s41567-023-01977-w">https://doi.org/10.1038/s41567-023-01977-w</a>.
  ieee: L. Bocanegra, A. Singh, E. B. Hannezo, M. P. Zagórski, and A. Kicheva, “Cell
    cycle dynamics control fluidity of the developing mouse neuroepithelium,” <i>Nature
    Physics</i>, vol. 19. Springer Nature, pp. 1050–1058, 2023.
  ista: Bocanegra L, Singh A, Hannezo EB, Zagórski MP, Kicheva A. 2023. Cell cycle
    dynamics control fluidity of the developing mouse neuroepithelium. Nature Physics.
    19, 1050–1058.
  mla: Bocanegra, Laura, et al. “Cell Cycle Dynamics Control Fluidity of the Developing
    Mouse Neuroepithelium.” <i>Nature Physics</i>, vol. 19, Springer Nature, 2023,
    pp. 1050–58, doi:<a href="https://doi.org/10.1038/s41567-023-01977-w">10.1038/s41567-023-01977-w</a>.
  short: L. Bocanegra, A. Singh, E.B. Hannezo, M.P. Zagórski, A. Kicheva, Nature Physics
    19 (2023) 1050–1058.
corr_author: '1'
date_created: 2023-04-16T22:01:09Z
date_published: 2023-07-01T00:00:00Z
date_updated: 2026-05-05T22:31:03Z
day: '01'
ddc:
- '570'
department:
- _id: EdHa
- _id: AnKi
doi: 10.1038/s41567-023-01977-w
ec_funded: 1
external_id:
  isi:
  - '000964029300003'
  pmid:
  - '37456593'
file:
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has_accepted_license: '1'
intvolume: '        19'
isi: 1
language:
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month: '07'
oa: 1
oa_version: Published Version
page: 1050-1058
pmid: 1
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
  call_identifier: H2020
  grant_number: '680037'
  name: Coordination of Patterning And Growth In the Spinal Cord
- _id: bd7e737f-d553-11ed-ba76-d69ffb5ee3aa
  grant_number: '101044579'
  name: Mechanisms of tissue size regulation in spinal cord development
- _id: 059DF620-7A3F-11EA-A408-12923DDC885E
  grant_number: F7802
  name: Stem Cell Modulation in Neural Development and Regeneration/ P02-Morphogen
    control of growth and pattern in the spinal cord
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: Nature Physics
publication_identifier:
  eissn:
  - 1745-2481
  issn:
  - 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
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scopus_import: '1'
status: public
title: Cell cycle dynamics control fluidity of the developing mouse neuroepithelium
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2023'
...
---
OA_place: publisher
_id: '13081'
abstract:
- lang: eng
  text: During development, tissues undergo changes in size and shape to form functional
    organs. Distinct cellular processes such as cell division and cell rearrangements
    underlie tissue morphogenesis. Yet how the distinct processes are controlled and
    coordinated, and how they contribute to morphogenesis is poorly understood. In
    our study, we addressed these questions using the developing mouse neural tube.
    This epithelial organ transforms from a flat epithelial sheet to an epithelial
    tube while increasing in size and undergoing morpho-gen-mediated patterning. The
    extent and mechanism of neural progenitor rearrangement within the developing
    mouse neuroepithelium is unknown. To investigate this, we per-formed high resolution
    lineage tracing analysis to quantify the extent of epithelial rear-rangement at
    different stages of neural tube development. We quantitatively described the relationship
    between apical cell size with cell cycle dependent interkinetic nuclear migra-tions
    (IKNM) and performed high cellular resolution live imaging of the neuroepithelium
    to study the dynamics of junctional remodeling.  Furthermore, developed a vertex
    model of the neuroepithelium to investigate the quantitative contribution of cell
    proliferation, cell differentiation and mechanical properties to the epithelial
    rearrangement dynamics and validated the model predictions through functional
    experiments. Our analysis revealed that at early developmental stages, the apical
    cell area kinetics driven by IKNM induce high lev-els of cell rearrangements in
    a regime of high junctional tension and contractility. After E9.5, there is a
    sharp decline in the extent of cell rearrangements, suggesting that the epi-thelium
    transitions from a fluid-like to a solid-like state. We found that this transition
    is regulated by the growth rate of the tissue, rather than by changes in cell-cell
    adhesion and contractile forces. Overall, our study provides a quantitative description
    of the relationship between tissue growth, cell cycle dynamics, epithelia rearrangements
    and the emergent tissue material properties, and novel insights on how epithelial
    cell dynamics influences tissue morphogenesis.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Laura
  full_name: Bocanegra, Laura
  id: 4896F754-F248-11E8-B48F-1D18A9856A87
  last_name: Bocanegra
citation:
  ama: Bocanegra L. Epithelial dynamics during mouse neural tube development. 2023.
    doi:<a href="https://doi.org/10.15479/at:ista:13081">10.15479/at:ista:13081</a>
  apa: Bocanegra, L. (2023). <i>Epithelial dynamics during mouse neural tube development</i>.
    Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/at:ista:13081">https://doi.org/10.15479/at:ista:13081</a>
  chicago: Bocanegra, Laura. “Epithelial Dynamics during Mouse Neural Tube Development.”
    Institute of Science and Technology Austria, 2023. <a href="https://doi.org/10.15479/at:ista:13081">https://doi.org/10.15479/at:ista:13081</a>.
  ieee: L. Bocanegra, “Epithelial dynamics during mouse neural tube development,”
    Institute of Science and Technology Austria, 2023.
  ista: Bocanegra L. 2023. Epithelial dynamics during mouse neural tube development.
    Institute of Science and Technology Austria.
  mla: Bocanegra, Laura. <i>Epithelial Dynamics during Mouse Neural Tube Development</i>.
    Institute of Science and Technology Austria, 2023, doi:<a href="https://doi.org/10.15479/at:ista:13081">10.15479/at:ista:13081</a>.
  short: L. Bocanegra, Epithelial Dynamics during Mouse Neural Tube Development, Institute
    of Science and Technology Austria, 2023.
corr_author: '1'
date_created: 2023-05-23T19:10:42Z
date_published: 2023-05-23T00:00:00Z
date_updated: 2026-04-14T09:50:54Z
day: '23'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: AnKi
doi: 10.15479/at:ista:13081
file:
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file_date_updated: 2024-06-01T22:30:04Z
has_accepted_license: '1'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: '93'
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '9349'
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    status: public
  - id: '12837'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Anna
  full_name: Kicheva, Anna
  id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
  last_name: Kicheva
  orcid: 0000-0003-4509-4998
title: Epithelial dynamics during mouse neural tube development
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2023'
...
---
_id: '14613'
abstract:
- lang: eng
  text: 'Many insects carry an ancient X chromosome - the Drosophila Muller element
    F - that likely predates their origin. Interestingly, the X has undergone turnover
    in multiple fly species (Diptera) after being conserved for more than 450 MY.
    The long evolutionary distance between Diptera and other sequenced insect clades
    makes it difficult to infer what could have contributed to this sudden increase
    in rate of turnover. Here, we produce the first genome and transcriptome of a
    long overlooked sister-order to Diptera: Mecoptera. We compare the scorpionfly
    Panorpa cognata X-chromosome gene content, expression, and structure, to that
    of several dipteran species as well as more distantly-related insect orders (Orthoptera
    and Blattodea). We find high conservation of gene content between the mecopteran
    X and the dipteran Muller F element, as well as several shared biological features,
    such as the presence of dosage compensation and a low amount of genetic diversity,
    consistent with a low recombination rate. However, the two homologous X chromosomes
    differ strikingly in their size and number of genes they carry. Our results therefore
    support a common ancestry of the mecopteran and ancestral dipteran X chromosomes,
    and suggest that Muller element F shrank in size and gene content after the split
    of Diptera and Mecoptera, which may have contributed to its turnover in dipteran
    insects.'
acknowledged_ssus:
- _id: ScienComp
acknowledgement: "We thank the Vicoso lab for their assistance with specimen collection,
  and Tim Connallon for valuable comments and suggestions on earlier versions of the
  manuscript. Computational resources and support were provided by the Scientific
  Computing unit at the ISTA. This research was supported by grants from the Austrian
  Science Foundation to C.L.\r\n(FWF ESP 39), and to B.V. (FWF SFB F88-10)."
article_number: msad245
article_processing_charge: Yes
article_type: original
author:
- first_name: Clementine
  full_name: Lasne, Clementine
  id: 02225f57-50d2-11eb-9ed8-8c92b9a34237
  last_name: Lasne
  orcid: 0000-0002-1197-8616
- first_name: Marwan N
  full_name: Elkrewi, Marwan N
  id: 0B46FACA-A8E1-11E9-9BD3-79D1E5697425
  last_name: Elkrewi
  orcid: 0000-0002-5328-7231
- first_name: Melissa A
  full_name: Toups, Melissa A
  id: 4E099E4E-F248-11E8-B48F-1D18A9856A87
  last_name: Toups
  orcid: 0000-0002-9752-7380
- first_name: Lorena Alexandra
  full_name: Layana Franco, Lorena Alexandra
  id: 02814589-eb8f-11eb-b029-a70074f3f18f
  last_name: Layana Franco
  orcid: 0000-0002-1253-6297
- first_name: Ariana
  full_name: Macon, Ariana
  id: 2A0848E2-F248-11E8-B48F-1D18A9856A87
  last_name: Macon
- first_name: Beatriz
  full_name: Vicoso, Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
citation:
  ama: Lasne C, Elkrewi MN, Toups MA, Layana Franco LA, Macon A, Vicoso B. The scorpionfly
    (Panorpa cognata) genome highlights conserved and derived features of the peculiar
    dipteran X chromosome. <i>Molecular Biology and Evolution</i>. 2023;40(12). doi:<a
    href="https://doi.org/10.1093/molbev/msad245">10.1093/molbev/msad245</a>
  apa: Lasne, C., Elkrewi, M. N., Toups, M. A., Layana Franco, L. A., Macon, A., &#38;
    Vicoso, B. (2023). The scorpionfly (Panorpa cognata) genome highlights conserved
    and derived features of the peculiar dipteran X chromosome. <i>Molecular Biology
    and Evolution</i>. Oxford University Press. <a href="https://doi.org/10.1093/molbev/msad245">https://doi.org/10.1093/molbev/msad245</a>
  chicago: Lasne, Clementine, Marwan N Elkrewi, Melissa A Toups, Lorena Alexandra
    Layana Franco, Ariana Macon, and Beatriz Vicoso. “The Scorpionfly (Panorpa Cognata)
    Genome Highlights Conserved and Derived Features of the Peculiar Dipteran X Chromosome.”
    <i>Molecular Biology and Evolution</i>. Oxford University Press, 2023. <a href="https://doi.org/10.1093/molbev/msad245">https://doi.org/10.1093/molbev/msad245</a>.
  ieee: C. Lasne, M. N. Elkrewi, M. A. Toups, L. A. Layana Franco, A. Macon, and B.
    Vicoso, “The scorpionfly (Panorpa cognata) genome highlights conserved and derived
    features of the peculiar dipteran X chromosome,” <i>Molecular Biology and Evolution</i>,
    vol. 40, no. 12. Oxford University Press, 2023.
  ista: Lasne C, Elkrewi MN, Toups MA, Layana Franco LA, Macon A, Vicoso B. 2023.
    The scorpionfly (Panorpa cognata) genome highlights conserved and derived features
    of the peculiar dipteran X chromosome. Molecular Biology and Evolution. 40(12),
    msad245.
  mla: Lasne, Clementine, et al. “The Scorpionfly (Panorpa Cognata) Genome Highlights
    Conserved and Derived Features of the Peculiar Dipteran X Chromosome.” <i>Molecular
    Biology and Evolution</i>, vol. 40, no. 12, msad245, Oxford University Press,
    2023, doi:<a href="https://doi.org/10.1093/molbev/msad245">10.1093/molbev/msad245</a>.
  short: C. Lasne, M.N. Elkrewi, M.A. Toups, L.A. Layana Franco, A. Macon, B. Vicoso,
    Molecular Biology and Evolution 40 (2023).
corr_author: '1'
date_created: 2023-11-27T16:14:37Z
date_published: 2023-12-01T00:00:00Z
date_updated: 2026-05-05T22:31:10Z
day: '01'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1093/molbev/msad245
external_id:
  isi:
  - '001122489000003'
  pmid:
  - '37988296'
file:
- access_level: open_access
  checksum: 47c1c72fb499f26ea52d216b242208c8
  content_type: application/pdf
  creator: dernst
  date_created: 2024-01-02T11:39:38Z
  date_updated: 2024-01-02T11:39:38Z
  file_id: '14727'
  file_name: 2023_MolecularBioEvo_Lasne.pdf
  file_size: 8623505
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  success: 1
file_date_updated: 2024-01-02T11:39:38Z
has_accepted_license: '1'
intvolume: '        40'
isi: 1
issue: '12'
keyword:
- Genetics
- Molecular Biology
- Ecology
- Evolution
- Behavior and Systematics
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 34ae1506-11ca-11ed-8bc3-c14f4c474396
  grant_number: F8810
  name: The highjacking of meiosis for asexual reproduction
- _id: ebb230e0-77a9-11ec-83b8-87a37e0241d3
  grant_number: ESP39 49461
  name: Mechanisms and Evolution of Reproductive Plasticity
publication: Molecular Biology and Evolution
publication_identifier:
  eissn:
  - 1537-1719
  issn:
  - 0737-4038
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
related_material:
  link:
  - description: News on ISTA webpage
    relation: press_release
    url: https://ista.ac.at/en/news/on-the-hunt/
  record:
  - id: '14614'
    relation: research_data
    status: public
  - id: '19386'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: The scorpionfly (Panorpa cognata) genome highlights conserved and derived features
  of the peculiar dipteran X chromosome
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 40
year: '2023'
...
---
APC_amount: 6228 EUR
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '13200'
abstract:
- lang: eng
  text: Recent quantum technologies have established precise quantum control of various
    microscopic systems using electromagnetic waves. Interfaces based on cryogenic
    cavity electro-optic systems are particularly promising, due to the direct interaction
    between microwave and optical fields in the quantum regime. Quantum optical control
    of superconducting microwave circuits has been precluded so far due to the weak
    electro-optical coupling as well as quasi-particles induced by the pump laser.
    Here we report the coherent control of a superconducting microwave cavity using
    laser pulses in a multimode electro-optical device at millikelvin temperature
    with near-unity cooperativity. Both the stationary and instantaneous responses
    of the microwave and optical modes comply with the coherent electro-optical interaction,
    and reveal only minuscule amount of excess back-action with an unanticipated time
    delay. Our demonstration enables wide ranges of applications beyond quantum transductions,
    from squeezing and quantum non-demolition measurements of microwave fields, to
    entanglement generation and hybrid quantum networks.
acknowledgement: This work was supported by the European Research Council under grant
  agreement no. 758053 (ERC StG QUNNECT), the European Union’s Horizon 2020 research
  and innovation program under grant agreement no. 899354 (FETopen SuperQuLAN), and
  the Austrian Science Fund (FWF) through BeyondC (F7105). L.Q. acknowledges generous
  support from the ISTFELLOW programme. W.H. is the recipient of an ISTplus postdoctoral
  fellowship with funding from the European Union’s Horizon 2020 research and innovation
  program under the Marie Skłodowska-Curie grant agreement no. 754411. G.A. is the
  recipient of a DOC fellowship of the Austrian Academy of Sciences at IST Austria.
article_number: '3784'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Liu
  full_name: Qiu, Liu
  id: 45e99c0d-1eb1-11eb-9b96-ed8ab2983cac
  last_name: Qiu
  orcid: 0000-0003-4345-4267
- first_name: Rishabh
  full_name: Sahu, Rishabh
  id: 47D26E34-F248-11E8-B48F-1D18A9856A87
  last_name: Sahu
  orcid: 0000-0001-6264-2162
- first_name: William J
  full_name: Hease, William J
  id: 29705398-F248-11E8-B48F-1D18A9856A87
  last_name: Hease
  orcid: 0000-0001-9868-2166
- first_name: Georg M
  full_name: Arnold, Georg M
  id: 3770C838-F248-11E8-B48F-1D18A9856A87
  last_name: Arnold
  orcid: 0000-0003-1397-7876
- first_name: Johannes M
  full_name: Fink, Johannes M
  id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
  last_name: Fink
  orcid: 0000-0001-8112-028X
citation:
  ama: Qiu L, Sahu R, Hease WJ, Arnold GM, Fink JM. Coherent optical control of a
    superconducting microwave cavity via electro-optical dynamical back-action. <i>Nature
    Communications</i>. 2023;14. doi:<a href="https://doi.org/10.1038/s41467-023-39493-3">10.1038/s41467-023-39493-3</a>
  apa: Qiu, L., Sahu, R., Hease, W. J., Arnold, G. M., &#38; Fink, J. M. (2023). Coherent
    optical control of a superconducting microwave cavity via electro-optical dynamical
    back-action. <i>Nature Communications</i>. Nature Research. <a href="https://doi.org/10.1038/s41467-023-39493-3">https://doi.org/10.1038/s41467-023-39493-3</a>
  chicago: Qiu, Liu, Rishabh Sahu, William J Hease, Georg M Arnold, and Johannes M
    Fink. “Coherent Optical Control of a Superconducting Microwave Cavity via Electro-Optical
    Dynamical Back-Action.” <i>Nature Communications</i>. Nature Research, 2023. <a
    href="https://doi.org/10.1038/s41467-023-39493-3">https://doi.org/10.1038/s41467-023-39493-3</a>.
  ieee: L. Qiu, R. Sahu, W. J. Hease, G. M. Arnold, and J. M. Fink, “Coherent optical
    control of a superconducting microwave cavity via electro-optical dynamical back-action,”
    <i>Nature Communications</i>, vol. 14. Nature Research, 2023.
  ista: Qiu L, Sahu R, Hease WJ, Arnold GM, Fink JM. 2023. Coherent optical control
    of a superconducting microwave cavity via electro-optical dynamical back-action.
    Nature Communications. 14, 3784.
  mla: Qiu, Liu, et al. “Coherent Optical Control of a Superconducting Microwave Cavity
    via Electro-Optical Dynamical Back-Action.” <i>Nature Communications</i>, vol.
    14, 3784, Nature Research, 2023, doi:<a href="https://doi.org/10.1038/s41467-023-39493-3">10.1038/s41467-023-39493-3</a>.
  short: L. Qiu, R. Sahu, W.J. Hease, G.M. Arnold, J.M. Fink, Nature Communications
    14 (2023).
corr_author: '1'
date_created: 2023-07-09T22:01:11Z
date_published: 2023-06-24T00:00:00Z
date_updated: 2026-05-05T22:31:11Z
day: '24'
ddc:
- '000'
department:
- _id: JoFi
doi: 10.1038/s41467-023-39493-3
ec_funded: 1
external_id:
  arxiv:
  - '2210.12443'
  isi:
  - '001018100800002'
  pmid:
  - '37355691'
file:
- access_level: open_access
  checksum: ec7ccd2c08f90d59cab302fd0d7776a4
  content_type: application/pdf
  creator: alisjak
  date_created: 2023-07-10T10:10:54Z
  date_updated: 2023-07-10T10:10:54Z
  file_id: '13206'
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  success: 1
file_date_updated: 2023-07-10T10:10:54Z
has_accepted_license: '1'
intvolume: '        14'
isi: 1
language:
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month: '06'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 26336814-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '758053'
  name: A Fiber Optic Transceiver for Superconducting Qubits
- _id: 9B868D20-BA93-11EA-9121-9846C619BF3A
  call_identifier: H2020
  grant_number: '899354'
  name: Quantum Local Area Networks with Superconducting Qubits
- _id: bdb108fd-d553-11ed-ba76-83dc74a9864f
  grant_number: F07105
  name: QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration
    of Superconducting Quantum Circuits
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
- _id: 2671EB66-B435-11E9-9278-68D0E5697425
  name: Coherent on-chip conversion of superconducting qubit signals from microwaves
    to optical frequencies
- _id: 3AC91DDA-15DF-11EA-824D-93A3E7B544D1
  call_identifier: FWF
  name: FWF Open Access Fund
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Nature Research
quality_controlled: '1'
related_material:
  record:
  - id: '18871'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Coherent optical control of a superconducting microwave cavity via electro-optical
  dynamical back-action
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2023'
...
---
OA_place: repository
_id: '18953'
abstract:
- lang: eng
  text: The rapid development of superconducting quantum hardware is expected to run
    into significant I/O restrictions due to the need for large-scale error correction
    in a cryogenic environment. Classical data centers rely on fiber-optic interconnects
    to remove similar networking bottlenecks and to allow for reconfigurable, software-defined
    infrastructures. In the same spirit, ultra-cold electro-optic links have been
    proposed and used to generate qubit control signals, or to replace cryogenic readout
    electronics. So far, the latter suffered from either low efficiency, low bandwidth
    and the need for additional microwave drives, or breaking of Cooper pairs and
    qubit states. In this work we realize electro-optic microwave photonics at millikelvin
    temperatures to implement a radio-over-fiber qubit readout that does not require
    any active or passive cryogenic microwave equipment. We demonstrate all-optical
    single-shot-readout by means of the Jaynes-Cummings nonlinearity in a circulator-free
    readout scheme. Importantly, we do not observe any direct radiation impact on
    the qubit state as verified with high-fidelity quantum-non-demolition measurements
    despite the absence of shielding elements. This compatibility between superconducting
    circuits and telecom wavelength light is not only a prerequisite to establish
    modular quantum networks, it is also relevant for multiplexed readout of superconducting
    photon detectors and classical superconducting logic. Moreover, this experiment
    showcases the potential of electro-optic radiometry in harsh environments - an
    electronics-free sensing principle that extends into the THz regime with applications
    in radio astronomy, planetary missions and earth observation.
acknowledgement: "We thank F. Hassani and M. Zemlicka for assistance\r\nwith qubit
  design and high power readout respectively,\r\nand P. Winkel and I. Pop at KIT for
  providing the JPA.\r\nThis work was supported by the European Research\r\nCouncil
  under grant agreement no. 758053 (ERC StG\r\nQUNNECT) and no. 101089099 (ERC CoG
  cQEO), the\r\nEuropean Union’s Horizon 2020 research and innovation\r\nprogram under
  grant agreement no. 899354 (FETopen\r\nSuperQuLAN) and the Austrian Science Fund
  (FWF)\r\nthrough BeyondC (grant no. F7105). L.Q. acknowledges\r\ngenerous support
  from the ISTFELLOW programme\r\nand G.A. is the recipient of a DOC fellowship of
  the\r\nAustrian Academy of Sciences at IST Austria."
article_processing_charge: No
arxiv: 1
author:
- first_name: Georg M
  full_name: Arnold, Georg M
  id: 3770C838-F248-11E8-B48F-1D18A9856A87
  last_name: Arnold
  orcid: 0000-0003-1397-7876
- first_name: Thomas
  full_name: Werner, Thomas
  id: 1fcd8497-dba3-11ea-a45e-c6fbd715f7c7
  last_name: Werner
  orcid: 0009-0001-2346-5236
- first_name: Rishabh
  full_name: Sahu, Rishabh
  id: 47D26E34-F248-11E8-B48F-1D18A9856A87
  last_name: Sahu
  orcid: 0000-0001-6264-2162
- first_name: Lucky
  full_name: Kapoor, Lucky
  id: 84b9700b-15b2-11ec-abd3-831089e67615
  last_name: Kapoor
  orcid: 0000-0001-8319-2148
- first_name: Liu
  full_name: Qiu, Liu
  id: 45e99c0d-1eb1-11eb-9b96-ed8ab2983cac
  last_name: Qiu
  orcid: 0000-0003-4345-4267
- first_name: Johannes M
  full_name: Fink, Johannes M
  id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
  last_name: Fink
  orcid: 0000-0001-8112-028X
citation:
  ama: Arnold GM, Werner T, Sahu R, Kapoor L, Qiu L, Fink JM. All-optical single-shot
    readout of a superconducting qubit. <i>arXiv</i>. doi:<a href="https://doi.org/10.48550/ARXIV.2310.16817">10.48550/ARXIV.2310.16817</a>
  apa: Arnold, G. M., Werner, T., Sahu, R., Kapoor, L., Qiu, L., &#38; Fink, J. M.
    (n.d.). All-optical single-shot readout of a superconducting qubit. <i>arXiv</i>.
    <a href="https://doi.org/10.48550/ARXIV.2310.16817">https://doi.org/10.48550/ARXIV.2310.16817</a>
  chicago: Arnold, Georg M, Thomas Werner, Rishabh Sahu, Lucky Kapoor, Liu Qiu, and
    Johannes M Fink. “All-Optical Single-Shot Readout of a Superconducting Qubit.”
    <i>ArXiv</i>, n.d. <a href="https://doi.org/10.48550/ARXIV.2310.16817">https://doi.org/10.48550/ARXIV.2310.16817</a>.
  ieee: G. M. Arnold, T. Werner, R. Sahu, L. Kapoor, L. Qiu, and J. M. Fink, “All-optical
    single-shot readout of a superconducting qubit,” <i>arXiv</i>. .
  ista: Arnold GM, Werner T, Sahu R, Kapoor L, Qiu L, Fink JM. All-optical single-shot
    readout of a superconducting qubit. arXiv, <a href="https://doi.org/10.48550/ARXIV.2310.16817">10.48550/ARXIV.2310.16817</a>.
  mla: Arnold, Georg M., et al. “All-Optical Single-Shot Readout of a Superconducting
    Qubit.” <i>ArXiv</i>, doi:<a href="https://doi.org/10.48550/ARXIV.2310.16817">10.48550/ARXIV.2310.16817</a>.
  short: G.M. Arnold, T. Werner, R. Sahu, L. Kapoor, L. Qiu, J.M. Fink, ArXiv (n.d.).
corr_author: '1'
date_created: 2025-01-29T11:11:34Z
date_published: 2023-10-25T00:00:00Z
date_updated: 2026-05-05T22:31:11Z
day: '25'
department:
- _id: JoFi
doi: 10.48550/ARXIV.2310.16817
ec_funded: 1
external_id:
  arxiv:
  - '2310.16817'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2310.16817
month: '10'
oa: 1
oa_version: Preprint
project:
- _id: 26336814-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '758053'
  name: A Fiber Optic Transceiver for Superconducting Qubits
- _id: bdadfa0d-d553-11ed-ba76-fb85edbd456a
  grant_number: '101089099'
  name: 'Cavity Quantum Electro Optics: Microwave photonics with nonclassical states'
- _id: 9B868D20-BA93-11EA-9121-9846C619BF3A
  call_identifier: H2020
  grant_number: '899354'
  name: Quantum Local Area Networks with Superconducting Qubits
- _id: 2671EB66-B435-11E9-9278-68D0E5697425
  name: Coherent on-chip conversion of superconducting qubit signals from microwaves
    to optical frequencies
- _id: bdb108fd-d553-11ed-ba76-83dc74a9864f
  grant_number: F07105
  name: QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration
    of Superconducting Quantum Circuits
publication: arXiv
publication_status: draft
related_material:
  record:
  - id: '19073'
    relation: later_version
    status: public
  - id: '18871'
    relation: dissertation_contains
    status: public
status: public
title: All-optical single-shot readout of a superconducting qubit
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '13117'
abstract:
- lang: eng
  text: The ability to control the direction of scattered light is crucial to provide
    flexibility and scalability for a wide range of on-chip applications, such as
    integrated photonics, quantum information processing, and nonlinear optics. Tunable
    directionality can be achieved by applying external magnetic fields that modify
    optical selection rules, by using nonlinear effects, or interactions with vibrations.
    However, these approaches are less suitable to control microwave photon propagation
    inside integrated superconducting quantum devices. Here, we demonstrate on-demand
    tunable directional scattering based on two periodically modulated transmon qubits
    coupled to a transmission line at a fixed distance. By changing the relative phase
    between the modulation tones, we realize unidirectional forward or backward photon
    scattering. Such an in-situ switchable mirror represents a versatile tool for
    intra- and inter-chip microwave photonic processors. In the future, a lattice
    of qubits can be used to realize topological circuits that exhibit strong nonreciprocity
    or chirality.
acknowledged_ssus:
- _id: M-Shop
- _id: NanoFab
acknowledgement: The authors thank W.D. Oliver for discussions, L. Drmic and P. Zielinski
  for software development, and the MIBA workshop and the IST nanofabrication facility
  for technical support. This work was supported by the Austrian Science Fund (FWF)
  through BeyondC (F7105) and IST Austria. E.R. is the recipient of a DOC fellowship
  of the Austrian Academy of Sciences at IST Austria. J.M.F. and M.Z. acknowledge
  support from the European Research Council under grant agreement No 758053 (ERC
  StG QUNNECT) and a NOMIS foundation research grant. The work of A.N.P. and A.V.P.
  has been supported by the Russian Science Foundation under the grant No 20-12-00194.
article_number: '2998'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Elena
  full_name: Redchenko, Elena
  id: 2C21D6E8-F248-11E8-B48F-1D18A9856A87
  last_name: Redchenko
- first_name: Alexander V.
  full_name: Poshakinskiy, Alexander V.
  last_name: Poshakinskiy
- first_name: Riya
  full_name: Sett, Riya
  id: 2E6D040E-F248-11E8-B48F-1D18A9856A87
  last_name: Sett
  orcid: 0000-0001-7641-8348
- first_name: Martin
  full_name: Zemlicka, Martin
  id: 2DCF8DE6-F248-11E8-B48F-1D18A9856A87
  last_name: Zemlicka
  orcid: 0009-0005-0878-3032
- first_name: Alexander N.
  full_name: Poddubny, Alexander N.
  last_name: Poddubny
- first_name: Johannes M
  full_name: Fink, Johannes M
  id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
  last_name: Fink
  orcid: 0000-0001-8112-028X
citation:
  ama: Redchenko E, Poshakinskiy AV, Sett R, Zemlicka M, Poddubny AN, Fink JM. Tunable
    directional photon scattering from a pair of superconducting qubits. <i>Nature
    Communications</i>. 2023;14. doi:<a href="https://doi.org/10.1038/s41467-023-38761-6">10.1038/s41467-023-38761-6</a>
  apa: Redchenko, E., Poshakinskiy, A. V., Sett, R., Zemlicka, M., Poddubny, A. N.,
    &#38; Fink, J. M. (2023). Tunable directional photon scattering from a pair of
    superconducting qubits. <i>Nature Communications</i>. Springer Nature. <a href="https://doi.org/10.1038/s41467-023-38761-6">https://doi.org/10.1038/s41467-023-38761-6</a>
  chicago: Redchenko, Elena, Alexander V. Poshakinskiy, Riya Sett, Martin Zemlicka,
    Alexander N. Poddubny, and Johannes M Fink. “Tunable Directional Photon Scattering
    from a Pair of Superconducting Qubits.” <i>Nature Communications</i>. Springer
    Nature, 2023. <a href="https://doi.org/10.1038/s41467-023-38761-6">https://doi.org/10.1038/s41467-023-38761-6</a>.
  ieee: E. Redchenko, A. V. Poshakinskiy, R. Sett, M. Zemlicka, A. N. Poddubny, and
    J. M. Fink, “Tunable directional photon scattering from a pair of superconducting
    qubits,” <i>Nature Communications</i>, vol. 14. Springer Nature, 2023.
  ista: Redchenko E, Poshakinskiy AV, Sett R, Zemlicka M, Poddubny AN, Fink JM. 2023.
    Tunable directional photon scattering from a pair of superconducting qubits. Nature
    Communications. 14, 2998.
  mla: Redchenko, Elena, et al. “Tunable Directional Photon Scattering from a Pair
    of Superconducting Qubits.” <i>Nature Communications</i>, vol. 14, 2998, Springer
    Nature, 2023, doi:<a href="https://doi.org/10.1038/s41467-023-38761-6">10.1038/s41467-023-38761-6</a>.
  short: E. Redchenko, A.V. Poshakinskiy, R. Sett, M. Zemlicka, A.N. Poddubny, J.M.
    Fink, Nature Communications 14 (2023).
corr_author: '1'
date_created: 2023-06-04T22:01:02Z
date_published: 2023-05-24T00:00:00Z
date_updated: 2026-05-05T22:31:13Z
day: '24'
ddc:
- '530'
department:
- _id: JoFi
doi: 10.1038/s41467-023-38761-6
ec_funded: 1
external_id:
  arxiv:
  - '2205.03293'
  isi:
  - '001001099700002'
  pmid:
  - '37225689'
file:
- access_level: open_access
  checksum: a857df40f0882859c48a1ff1e2001ec2
  content_type: application/pdf
  creator: dernst
  date_created: 2023-06-06T07:31:20Z
  date_updated: 2023-06-06T07:31:20Z
  file_id: '13123'
  file_name: 2023_NaturePhysics_Redchenko.pdf
  file_size: 1654389
  relation: main_file
  success: 1
file_date_updated: 2023-06-06T07:31:20Z
has_accepted_license: '1'
intvolume: '        14'
isi: 1
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 26336814-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '758053'
  name: A Fiber Optic Transceiver for Superconducting Qubits
- _id: 26B354CA-B435-11E9-9278-68D0E5697425
  name: Controllable Collective States of Superconducting Qubit Ensembles
- _id: eb9b30ac-77a9-11ec-83b8-871f581d53d2
  name: Protected states of quantum matter
- _id: bdb108fd-d553-11ed-ba76-83dc74a9864f
  grant_number: F07105
  name: QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration
    of Superconducting Quantum Circuits
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  record:
  - id: '13124'
    relation: research_data
    status: public
  - id: '19533'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Tunable directional photon scattering from a pair of superconducting qubits
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2023'
...
---
_id: '12159'
abstract:
- lang: eng
  text: The term “haplotype block” is commonly used in the developing field of haplotype-based
    inference methods. We argue that the term should be defined based on the structure
    of the Ancestral Recombination Graph (ARG), which contains complete information
    on the ancestry of a sample. We use simulated examples to demonstrate key features
    of the relationship between haplotype blocks and ancestral structure, emphasizing
    the stochasticity of the processes that generate them. Even the simplest cases
    of neutrality or of a “hard” selective sweep produce a rich structure, often missed
    by commonly used statistics. We highlight a number of novel methods for inferring
    haplotype structure, based on the full ARG, or on a sequence of trees, and illustrate
    how they can be used to define haplotype blocks using an empirical data set. While
    the advent of new, computationally efficient methods makes it possible to apply
    these concepts broadly, they (and additional new methods) could benefit from adding
    features to explore haplotype blocks, as we define them. Understanding and applying
    the concept of the haplotype block will be essential to fully exploit long and
    linked-read sequencing technologies.
acknowledgement: 'We thank the Barton group for useful discussion and feedback during
  the writing of this article. Comments from Roger Butlin, Molly Schumer''s Group,
  the tskit development team, editors and three reviewers greatly improved the manuscript.
  Funding was provided by SCAS (Natural Sciences Programme, Knut and Alice Wallenberg
  Foundation), an FWF Wittgenstein grant (PT1001Z211), an FWF standalone grant (grant
  P 32166), and an ERC Advanced Grant. YFC was supported by the Max Planck Society
  and an ERC Proof of Concept Grant #101069216 (HAPLOTAGGING).'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Daria
  full_name: Shipilina, Daria
  id: 428A94B0-F248-11E8-B48F-1D18A9856A87
  last_name: Shipilina
  orcid: 0000-0002-1145-9226
- first_name: Arka
  full_name: Pal, Arka
  id: 6AAB2240-CA9A-11E9-9C1A-D9D1E5697425
  last_name: Pal
  orcid: 0000-0002-4530-8469
- first_name: Sean
  full_name: Stankowski, Sean
  id: 43161670-5719-11EA-8025-FABC3DDC885E
  last_name: Stankowski
- first_name: Yingguang Frank
  full_name: Chan, Yingguang Frank
  last_name: Chan
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Shipilina D, Pal A, Stankowski S, Chan YF, Barton NH. On the origin and structure
    of haplotype blocks. <i>Molecular Ecology</i>. 2023;32(6):1441-1457. doi:<a href="https://doi.org/10.1111/mec.16793">10.1111/mec.16793</a>
  apa: Shipilina, D., Pal, A., Stankowski, S., Chan, Y. F., &#38; Barton, N. H. (2023).
    On the origin and structure of haplotype blocks. <i>Molecular Ecology</i>. Wiley.
    <a href="https://doi.org/10.1111/mec.16793">https://doi.org/10.1111/mec.16793</a>
  chicago: Shipilina, Daria, Arka Pal, Sean Stankowski, Yingguang Frank Chan, and
    Nicholas H Barton. “On the Origin and Structure of Haplotype Blocks.” <i>Molecular
    Ecology</i>. Wiley, 2023. <a href="https://doi.org/10.1111/mec.16793">https://doi.org/10.1111/mec.16793</a>.
  ieee: D. Shipilina, A. Pal, S. Stankowski, Y. F. Chan, and N. H. Barton, “On the
    origin and structure of haplotype blocks,” <i>Molecular Ecology</i>, vol. 32,
    no. 6. Wiley, pp. 1441–1457, 2023.
  ista: Shipilina D, Pal A, Stankowski S, Chan YF, Barton NH. 2023. On the origin
    and structure of haplotype blocks. Molecular Ecology. 32(6), 1441–1457.
  mla: Shipilina, Daria, et al. “On the Origin and Structure of Haplotype Blocks.”
    <i>Molecular Ecology</i>, vol. 32, no. 6, Wiley, 2023, pp. 1441–57, doi:<a href="https://doi.org/10.1111/mec.16793">10.1111/mec.16793</a>.
  short: D. Shipilina, A. Pal, S. Stankowski, Y.F. Chan, N.H. Barton, Molecular Ecology
    32 (2023) 1441–1457.
corr_author: '1'
date_created: 2023-01-12T12:09:17Z
date_published: 2023-03-01T00:00:00Z
date_updated: 2026-05-05T22:31:12Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1111/mec.16793
external_id:
  isi:
  - '000900762000001'
  pmid:
  - '36433653'
file:
- access_level: open_access
  checksum: b10e0f8fa3dc4d72aaf77a557200978a
  content_type: application/pdf
  creator: dernst
  date_created: 2023-08-16T08:15:41Z
  date_updated: 2023-08-16T08:15:41Z
  file_id: '14062'
  file_name: 2023_MolecularEcology_Shipilina.pdf
  file_size: 7144607
  relation: main_file
  success: 1
file_date_updated: 2023-08-16T08:15:41Z
has_accepted_license: '1'
intvolume: '        32'
isi: 1
issue: '6'
keyword:
- Genetics
- Ecology
- Evolution
- Behavior and Systematics
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 1441-1457
pmid: 1
project:
- _id: 05959E1C-7A3F-11EA-A408-12923DDC885E
  grant_number: P32166
  name: Snapdragon Speciation
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z211
  name: Formal methods for the design and analysis of complex systems
- _id: bd6958e0-d553-11ed-ba76-86eba6a76c00
  grant_number: '101055327'
  name: Understanding the evolution of continuous genomes
publication: Molecular Ecology
publication_identifier:
  eissn:
  - 1365-294X
  issn:
  - 0962-1083
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
  record:
  - id: '20694'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: On the origin and structure of haplotype blocks
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 32
year: '2023'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '11442'
abstract:
- lang: eng
  text: "Enabling additive manufacturing to employ a wide range of novel, functional
    materials can be a major boost to this technology. However, making such materials
    printable requires painstaking trial-and-error by an expert operator,\r\nas they
    typically tend to exhibit peculiar rheological or hysteresis properties. Even
    in the case of successfully finding the process parameters, there is no guarantee
    of print-to-print consistency due to material differences between batches. These
    challenges make closed-loop feedback an attractive option where the process parameters
    are adjusted on-the-fly. There are several challenges for designing an efficient
    controller: the deposition parameters are complex and highly coupled, artifacts
    occur after long time horizons, simulating the deposition is computationally costly,
    and learning on hardware is intractable. In this work, we demonstrate the feasibility
    of learning a closed-loop control policy for additive manufacturing using reinforcement
    learning. We show that approximate, but efficient, numerical simulation is\r\nsufficient
    as long as it allows learning the behavioral patterns of deposition that translate
    to real-world experiences. In combination with reinforcement learning, our model
    can be used to discover control policies that outperform\r\nbaseline controllers.
    Furthermore, the recovered policies have a minimal sim-to-real gap. We showcase
    this by applying our control policy in-vivo on a single-layer, direct ink writing
    printer. "
acknowledgement: "This work is graciously supported by the following grant agencies:
  FWF Lise Meitner (Grant M 3319), SNSF (Grant 200502), ERC Starting Grant (MATERIALIZABLE-715767),
  NSF (Grant IIS-181507).\r\n"
article_number: '112'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Michael
  full_name: Piovarci, Michael
  id: 62E473F4-5C99-11EA-A40E-AF823DDC885E
  last_name: Piovarci
  orcid: 0000-0002-5062-4474
- first_name: Michael
  full_name: Foshey, Michael
  last_name: Foshey
- first_name: Jie
  full_name: Xu, Jie
  last_name: Xu
- first_name: Timothy
  full_name: Erps, Timothy
  last_name: Erps
- first_name: Vahid
  full_name: Babaei, Vahid
  last_name: Babaei
- first_name: Piotr
  full_name: Didyk, Piotr
  last_name: Didyk
- first_name: Szymon
  full_name: Rusinkiewicz, Szymon
  last_name: Rusinkiewicz
- first_name: Wojciech
  full_name: Matusik, Wojciech
  last_name: Matusik
- first_name: Bernd
  full_name: Bickel, Bernd
  id: 49876194-F248-11E8-B48F-1D18A9856A87
  last_name: Bickel
  orcid: 0000-0001-6511-9385
citation:
  ama: Piovarci M, Foshey M, Xu J, et al. Closed-loop control of direct ink writing
    via reinforcement learning. <i>ACM Transactions on Graphics</i>. 2022;41(4). doi:<a
    href="https://doi.org/10.1145/3528223.3530144">10.1145/3528223.3530144</a>
  apa: Piovarci, M., Foshey, M., Xu, J., Erps, T., Babaei, V., Didyk, P., … Bickel,
    B. (2022). Closed-loop control of direct ink writing via reinforcement learning.
    <i>ACM Transactions on Graphics</i>. Association for Computing Machinery. <a href="https://doi.org/10.1145/3528223.3530144">https://doi.org/10.1145/3528223.3530144</a>
  chicago: Piovarci, Michael, Michael Foshey, Jie Xu, Timothy Erps, Vahid Babaei,
    Piotr Didyk, Szymon Rusinkiewicz, Wojciech Matusik, and Bernd Bickel. “Closed-Loop
    Control of Direct Ink Writing via Reinforcement Learning.” <i>ACM Transactions
    on Graphics</i>. Association for Computing Machinery, 2022. <a href="https://doi.org/10.1145/3528223.3530144">https://doi.org/10.1145/3528223.3530144</a>.
  ieee: M. Piovarci <i>et al.</i>, “Closed-loop control of direct ink writing via
    reinforcement learning,” <i>ACM Transactions on Graphics</i>, vol. 41, no. 4.
    Association for Computing Machinery, 2022.
  ista: Piovarci M, Foshey M, Xu J, Erps T, Babaei V, Didyk P, Rusinkiewicz S, Matusik
    W, Bickel B. 2022. Closed-loop control of direct ink writing via reinforcement
    learning. ACM Transactions on Graphics. 41(4), 112.
  mla: Piovarci, Michael, et al. “Closed-Loop Control of Direct Ink Writing via Reinforcement
    Learning.” <i>ACM Transactions on Graphics</i>, vol. 41, no. 4, 112, Association
    for Computing Machinery, 2022, doi:<a href="https://doi.org/10.1145/3528223.3530144">10.1145/3528223.3530144</a>.
  short: M. Piovarci, M. Foshey, J. Xu, T. Erps, V. Babaei, P. Didyk, S. Rusinkiewicz,
    W. Matusik, B. Bickel, ACM Transactions on Graphics 41 (2022).
corr_author: '1'
date_created: 2022-06-10T06:41:47Z
date_published: 2022-06-01T00:00:00Z
date_updated: 2025-09-10T09:36:45Z
day: '01'
ddc:
- '000'
department:
- _id: BeBi
doi: 10.1145/3528223.3530144
ec_funded: 1
external_id:
  arxiv:
  - '2201.11819'
  isi:
  - '000830989200091'
file:
- access_level: open_access
  checksum: 27f6fe41c6ff84d50445cc9b0176d45b
  content_type: application/pdf
  creator: dernst
  date_created: 2022-06-28T08:32:58Z
  date_updated: 2022-06-28T08:32:58Z
  file_id: '11467'
  file_name: 2022_ACM_acceptedversion_Piovarci.pdf
  file_size: 33994829
  relation: main_file
  success: 1
file_date_updated: 2022-06-28T08:32:58Z
has_accepted_license: '1'
intvolume: '        41'
isi: 1
issue: '4'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Submitted Version
project:
- _id: eb901961-77a9-11ec-83b8-f5c883a62027
  grant_number: M03319
  name: Perception-Aware Appearance Fabrication
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '715767'
  name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
    Modeling'
publication: ACM Transactions on Graphics
publication_identifier:
  eissn:
  - 1557-7368
  issn:
  - 0730-0301
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
related_material:
  link:
  - description: News on ISTA website
    relation: press_release
    url: https://ista.ac.at/en/news/machine-learning-3d-printing-fluids/
scopus_import: '1'
status: public
title: Closed-loop control of direct ink writing via reinforcement learning
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 41
year: '2022'
...
---
_id: '11443'
abstract:
- lang: eng
  text: Sometimes, it is possible to represent a complicated polytope as a projection
    of a much simpler polytope. To quantify this phenomenon, the extension complexity
    of a polytope P is defined to be the minimum number of facets of a (possibly higher-dimensional)
    polytope from which P can be obtained as a (linear) projection. This notion is
    motivated by its relevance to combinatorial optimisation, and has been studied
    intensively for various specific polytopes associated with important optimisation
    problems. In this paper we study extension complexity as a parameter of general
    polytopes, more specifically considering various families of low-dimensional polytopes.
    First, we prove that for a fixed dimension d, the extension complexity of a random
    d-dimensional polytope (obtained as the convex hull of random points in a ball
    or on a sphere) is typically on the order of the square root of its number of
    vertices. Second, we prove that any cyclic n-vertex polygon (whose vertices lie
    on a circle) has extension complexity at most 24√n. This bound is tight up to
    the constant factor 24. Finally, we show that there exists an no(1)-dimensional
    polytope with at most n vertices and extension complexity n1−o(1). Our theorems
    are proved with a range of different techniques, which we hope will be of further
    interest.
acknowledgement: "The research of the first author was supported by SNSF Project 178493
  and NSF Award DMS-1953990. The research of the second author supported by NSF Award
  DMS-1953772.\r\nThe research of the third author was supported by NSF Award DMS-1764176,
  NSF CAREER Award DMS-2044606, a Sloan Research Fellowship, and the MIT Solomon Buchsbaum
  Fund. "
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Matthew Alan
  full_name: Kwan, Matthew Alan
  id: 5fca0887-a1db-11eb-95d1-ca9d5e0453b3
  last_name: Kwan
  orcid: 0000-0002-4003-7567
- first_name: Lisa
  full_name: Sauermann, Lisa
  last_name: Sauermann
- first_name: Yufei
  full_name: Zhao, Yufei
  last_name: Zhao
citation:
  ama: Kwan MA, Sauermann L, Zhao Y. Extension complexity of low-dimensional polytopes.
    <i>Transactions of the American Mathematical Society</i>. 2022;375(6):4209-4250.
    doi:<a href="https://doi.org/10.1090/tran/8614">10.1090/tran/8614</a>
  apa: Kwan, M. A., Sauermann, L., &#38; Zhao, Y. (2022). Extension complexity of
    low-dimensional polytopes. <i>Transactions of the American Mathematical Society</i>.
    American Mathematical Society. <a href="https://doi.org/10.1090/tran/8614">https://doi.org/10.1090/tran/8614</a>
  chicago: Kwan, Matthew Alan, Lisa Sauermann, and Yufei Zhao. “Extension Complexity
    of Low-Dimensional Polytopes.” <i>Transactions of the American Mathematical Society</i>.
    American Mathematical Society, 2022. <a href="https://doi.org/10.1090/tran/8614">https://doi.org/10.1090/tran/8614</a>.
  ieee: M. A. Kwan, L. Sauermann, and Y. Zhao, “Extension complexity of low-dimensional
    polytopes,” <i>Transactions of the American Mathematical Society</i>, vol. 375,
    no. 6. American Mathematical Society, pp. 4209–4250, 2022.
  ista: Kwan MA, Sauermann L, Zhao Y. 2022. Extension complexity of low-dimensional
    polytopes. Transactions of the American Mathematical Society. 375(6), 4209–4250.
  mla: Kwan, Matthew Alan, et al. “Extension Complexity of Low-Dimensional Polytopes.”
    <i>Transactions of the American Mathematical Society</i>, vol. 375, no. 6, American
    Mathematical Society, 2022, pp. 4209–50, doi:<a href="https://doi.org/10.1090/tran/8614">10.1090/tran/8614</a>.
  short: M.A. Kwan, L. Sauermann, Y. Zhao, Transactions of the American Mathematical
    Society 375 (2022) 4209–4250.
corr_author: '1'
date_created: 2022-06-12T22:01:45Z
date_published: 2022-06-01T00:00:00Z
date_updated: 2024-10-09T21:02:31Z
day: '01'
department:
- _id: MaKw
doi: 10.1090/tran/8614
external_id:
  arxiv:
  - '2006.08836'
  isi:
  - '000798461500001'
intvolume: '       375'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: ' https://doi.org/10.48550/arXiv.2006.08836'
month: '06'
oa: 1
oa_version: Preprint
page: 4209-4250
publication: Transactions of the American Mathematical Society
publication_identifier:
  eissn:
  - 1088-6850
  issn:
  - 0002-9947
publication_status: published
publisher: American Mathematical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Extension complexity of low-dimensional polytopes
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 375
year: '2022'
...
---
_id: '11444'
abstract:
- lang: eng
  text: "This article investigates library-related documents written by Gerard van
    Swieten (1700–72) during his tenure as Library Prefect in the Imperial Library
    of Vienna (1745–72). Van Swieten’s time as Library Prefect is considered through
    a textual analysis. Handwritten letters were deconstructed in terms of their appearance,
    layout, and tone in order to mine them for meaning. Furthermore, the contents
    were examined for library matters such as censorship, catalogues, and collection
    development. The Imperial Court Library held a prominent role as a repository
    for rare and valuable works, later becoming the National Library of Austria.\r\nGerard
    van Swieten’s work as a librarian tends to be overlooked, perhaps because he is
    better known as the private physician of Maria Theresia, as well as a medical
    reformer. Nevertheless, he was a hard-working chief librarian deeply involved
    in all aspects of librarianship. Van Swieten endorsed modern scientific works,
    which were otherwise banned officially by the censorship commission, for the use
    of scholars in the library, expanded the collection by acquiring books through
    his network of scholars and publishers, and reissued library catalogues. He also
    provided for the comfort of users in the library reading room, at a time when
    such considerations were unusual. In conclusion, a proposal is made that van Swieten
    viewed his role as librarian with some importance and pride."
article_processing_charge: No
article_type: original
author:
- first_name: Clara A
  full_name: Chlebak, Clara A
  id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
  last_name: Chlebak
  orcid: 0000-0002-3385-3865
- first_name: Peter H.
  full_name: Reid, Peter H.
  last_name: Reid
citation:
  ama: 'Chlebak CA, Reid PH. From the prefect’s desk: Gerard van Swieten’s library
    correspondence. <i>Library and Information History</i>. 2022;38(1):23-41. doi:<a
    href="https://doi.org/10.3366/lih.2022.0097">10.3366/lih.2022.0097</a>'
  apa: 'Chlebak, C. A., &#38; Reid, P. H. (2022). From the prefect’s desk: Gerard
    van Swieten’s library correspondence. <i>Library and Information History</i>.
    Edinburgh University Press. <a href="https://doi.org/10.3366/lih.2022.0097">https://doi.org/10.3366/lih.2022.0097</a>'
  chicago: 'Chlebak, Clara A, and Peter H. Reid. “From the Prefect’s Desk: Gerard
    van Swieten’s Library Correspondence.” <i>Library and Information History</i>.
    Edinburgh University Press, 2022. <a href="https://doi.org/10.3366/lih.2022.0097">https://doi.org/10.3366/lih.2022.0097</a>.'
  ieee: 'C. A. Chlebak and P. H. Reid, “From the prefect’s desk: Gerard van Swieten’s
    library correspondence,” <i>Library and Information History</i>, vol. 38, no.
    1. Edinburgh University Press, pp. 23–41, 2022.'
  ista: 'Chlebak CA, Reid PH. 2022. From the prefect’s desk: Gerard van Swieten’s
    library correspondence. Library and Information History. 38(1), 23–41.'
  mla: 'Chlebak, Clara A., and Peter H. Reid. “From the Prefect’s Desk: Gerard van
    Swieten’s Library Correspondence.” <i>Library and Information History</i>, vol.
    38, no. 1, Edinburgh University Press, 2022, pp. 23–41, doi:<a href="https://doi.org/10.3366/lih.2022.0097">10.3366/lih.2022.0097</a>.'
  short: C.A. Chlebak, P.H. Reid, Library and Information History 38 (2022) 23–41.
corr_author: '1'
date_created: 2022-06-12T22:01:45Z
date_published: 2022-04-01T00:00:00Z
date_updated: 2024-10-09T21:02:31Z
day: '01'
department:
- _id: E-Lib
doi: 10.3366/lih.2022.0097
intvolume: '        38'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://rgu-repository.worktribe.com/output/1635939
month: '04'
oa: 1
oa_version: Submitted Version
page: 23-41
publication: Library and Information History
publication_identifier:
  eissn:
  - 1758-3497
  issn:
  - 1758-3489
publication_status: published
publisher: Edinburgh University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'From the prefect’s desk: Gerard van Swieten’s library correspondence'
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 38
year: '2022'
...
---
_id: '11449'
abstract:
- lang: eng
  text: Mutations are acquired frequently, such that each cell's genome inscribes
    its history of cell divisions. Common genomic alterations involve loss of heterozygosity
    (LOH). LOH accumulates throughout the genome, offering large encoding capacity
    for inferring cell lineage. Using only single-cell RNA sequencing (scRNA-seq)
    of mouse brain cells, we found that LOH events spanning multiple genes are revealed
    as tracts of monoallelically expressed, constitutionally heterozygous single-nucleotide
    variants (SNVs). We simultaneously inferred cell lineage and marked developmental
    time points based on X chromosome inactivation and the total number of LOH events
    while identifying cell types from gene expression patterns. Our results are consistent
    with progenitor cells giving rise to multiple cortical cell types through stereotyped
    expansion and distinct waves of neurogenesis. This type of retrospective analysis
    could be incorporated into scRNA-seq pipelines and, compared with experimental
    approaches for determining lineage in model organisms, is applicable where genetic
    engineering is prohibited, such as humans.
acknowledgement: D.J.A. thanks Wayne K. Potts, Alan R. Rogers, Kristen Hawkes, Ryk
  Ward, and Jon Seger for inspiring a young undergraduate to apply evolutionary theory
  to intraorganism development. Supported by the Paul G. Allen Frontiers Group (University
  of Washington); NIH R00HG010152 (Dartmouth); and NÖ Forschung und Bildung n[f+b]
  life science call grant (C13-002) and the European Research Council (ERC) under
  the European Union’s Horizon 2020 research and innovation program 725780 LinPro
  to S.H.
article_processing_charge: No
article_type: original
author:
- first_name: Donovan J.
  full_name: Anderson, Donovan J.
  last_name: Anderson
- first_name: Florian
  full_name: Pauler, Florian
  id: 48EA0138-F248-11E8-B48F-1D18A9856A87
  last_name: Pauler
  orcid: 0000-0002-7462-0048
- first_name: Aaron
  full_name: Mckenna, Aaron
  last_name: Mckenna
- first_name: Jay
  full_name: Shendure, Jay
  last_name: Shendure
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: Marshall S.
  full_name: Horwitz, Marshall S.
  last_name: Horwitz
citation:
  ama: Anderson DJ, Pauler F, Mckenna A, Shendure J, Hippenmeyer S, Horwitz MS. Simultaneous
    brain cell type and lineage determined by scRNA-seq reveals stereotyped cortical
    development. <i>Cell Systems</i>. 2022;13(6):438-453.e5. doi:<a href="https://doi.org/10.1016/j.cels.2022.03.006">10.1016/j.cels.2022.03.006</a>
  apa: Anderson, D. J., Pauler, F., Mckenna, A., Shendure, J., Hippenmeyer, S., &#38;
    Horwitz, M. S. (2022). Simultaneous brain cell type and lineage determined by
    scRNA-seq reveals stereotyped cortical development. <i>Cell Systems</i>. Elsevier.
    <a href="https://doi.org/10.1016/j.cels.2022.03.006">https://doi.org/10.1016/j.cels.2022.03.006</a>
  chicago: Anderson, Donovan J., Florian Pauler, Aaron Mckenna, Jay Shendure, Simon
    Hippenmeyer, and Marshall S. Horwitz. “Simultaneous Brain Cell Type and Lineage
    Determined by ScRNA-Seq Reveals Stereotyped Cortical Development.” <i>Cell Systems</i>.
    Elsevier, 2022. <a href="https://doi.org/10.1016/j.cels.2022.03.006">https://doi.org/10.1016/j.cels.2022.03.006</a>.
  ieee: D. J. Anderson, F. Pauler, A. Mckenna, J. Shendure, S. Hippenmeyer, and M.
    S. Horwitz, “Simultaneous brain cell type and lineage determined by scRNA-seq
    reveals stereotyped cortical development,” <i>Cell Systems</i>, vol. 13, no. 6.
    Elsevier, p. 438–453.e5, 2022.
  ista: Anderson DJ, Pauler F, Mckenna A, Shendure J, Hippenmeyer S, Horwitz MS. 2022.
    Simultaneous brain cell type and lineage determined by scRNA-seq reveals stereotyped
    cortical development. Cell Systems. 13(6), 438–453.e5.
  mla: Anderson, Donovan J., et al. “Simultaneous Brain Cell Type and Lineage Determined
    by ScRNA-Seq Reveals Stereotyped Cortical Development.” <i>Cell Systems</i>, vol.
    13, no. 6, Elsevier, 2022, p. 438–453.e5, doi:<a href="https://doi.org/10.1016/j.cels.2022.03.006">10.1016/j.cels.2022.03.006</a>.
  short: D.J. Anderson, F. Pauler, A. Mckenna, J. Shendure, S. Hippenmeyer, M.S. Horwitz,
    Cell Systems 13 (2022) 438–453.e5.
date_created: 2022-06-19T22:01:57Z
date_published: 2022-06-15T00:00:00Z
date_updated: 2025-04-14T07:43:05Z
day: '15'
department:
- _id: SiHi
doi: 10.1016/j.cels.2022.03.006
ec_funded: 1
external_id:
  isi:
  - '000814124400002'
  pmid:
  - '35452605'
intvolume: '        13'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.cels.2022.03.006
month: '06'
oa: 1
oa_version: Published Version
page: 438-453.e5
pmid: 1
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '725780'
  name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
- _id: 25D92700-B435-11E9-9278-68D0E5697425
  grant_number: LS13-002
  name: Mapping Cell-Type Specificity of the Genomic Imprintome in the Brain
publication: Cell Systems
publication_identifier:
  eissn:
  - 2405-4720
  issn:
  - 2405-4712
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Simultaneous brain cell type and lineage determined by scRNA-seq reveals stereotyped
  cortical development
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13
year: '2022'
...
---
_id: '11451'
abstract:
- lang: eng
  text: The precursor conversion chemistry and surface chemistry of Cu3N and Cu3PdN
    nanocrystals are unknown or contested. Here, we first obtain phase-pure, colloidally
    stable nanocubes. Second, we elucidate the pathway by which copper(II) nitrate
    and oleylamine form Cu3N. We find that oleylamine is both a reductant and a nitrogen
    source. Oleylamine is oxidized by nitrate to a primary aldimine, which reacts
    further with excess oleylamine to a secondary aldimine, eliminating ammonia. Ammonia
    reacts with CuI to form Cu3N. Third, we investigated the surface chemistry and
    find a mixed ligand shell of aliphatic amines and carboxylates (formed in situ).
    While the carboxylates appear tightly bound, the amines are easily desorbed from
    the surface. Finally, we show that doping with palladium decreases the band gap
    and the material becomes semi-metallic. These results bring insight into the chemistry
    of metal nitrides and might help the development of other metal nitride nanocrystals.
acknowledgement: 'J.D.R. and M.P. acknowledge the SNF Eccellenza funding scheme (project
  number: 194172). We acknowledge DESY (Hamburg, Germany), a member of the Helmholtz
  Association HGF, for the provision of experimental facilities. Parts of this research
  were carried out at beamline P21.1, PETRA III. We thank Dr. Soham Banerjee for acquiring
  the PDF data and helpful advice. A.R. acknowledges the support from the Analytical
  Chemistry Trust Fund for her CAMS-UK Fellowship. C.K. acknowledges the support from
  the Department of Chemistry, UCL. The authors acknowledge Dr Stephan Lany from NREL
  for providing the Cu3N DFT calculations. The authors thank Prof. Raymond Schaak
  and Dr. Robert William Lord for helpful advice and suggestions regarding the purification
  procedure. Open access funding provided by Universitat Basel.'
article_number: e202207013
article_processing_charge: No
article_type: original
author:
- first_name: Mahsa
  full_name: Parvizian, Mahsa
  last_name: Parvizian
- first_name: Alejandra
  full_name: Duràn Balsa, Alejandra
  last_name: Duràn Balsa
- first_name: Rohan
  full_name: Pokratath, Rohan
  last_name: Pokratath
- first_name: Curran
  full_name: Kalha, Curran
  last_name: Kalha
- first_name: Seungho
  full_name: Lee, Seungho
  id: BB243B88-D767-11E9-B658-BC13E6697425
  last_name: Lee
  orcid: 0000-0002-6962-8598
- first_name: Dietger
  full_name: Van Den Eynden, Dietger
  last_name: Van Den Eynden
- first_name: Maria
  full_name: Ibáñez, Maria
  id: 43C61214-F248-11E8-B48F-1D18A9856A87
  last_name: Ibáñez
  orcid: 0000-0001-5013-2843
- first_name: Anna
  full_name: Regoutz, Anna
  last_name: Regoutz
- first_name: Jonathan
  full_name: De Roo, Jonathan
  last_name: De Roo
citation:
  ama: Parvizian M, Duràn Balsa A, Pokratath R, et al. The chemistry of Cu₃N and Cu₃PdN
    nanocrystals. <i>Angewandte Chemie - International Edition</i>. 2022;61(31). doi:<a
    href="https://doi.org/10.1002/anie.202207013">10.1002/anie.202207013</a>
  apa: Parvizian, M., Duràn Balsa, A., Pokratath, R., Kalha, C., Lee, S., Van Den
    Eynden, D., … De Roo, J. (2022). The chemistry of Cu₃N and Cu₃PdN nanocrystals.
    <i>Angewandte Chemie - International Edition</i>. Wiley. <a href="https://doi.org/10.1002/anie.202207013">https://doi.org/10.1002/anie.202207013</a>
  chicago: Parvizian, Mahsa, Alejandra Duràn Balsa, Rohan Pokratath, Curran Kalha,
    Seungho Lee, Dietger Van Den Eynden, Maria Ibáñez, Anna Regoutz, and Jonathan
    De Roo. “The Chemistry of Cu₃N and Cu₃PdN Nanocrystals.” <i>Angewandte Chemie
    - International Edition</i>. Wiley, 2022. <a href="https://doi.org/10.1002/anie.202207013">https://doi.org/10.1002/anie.202207013</a>.
  ieee: M. Parvizian <i>et al.</i>, “The chemistry of Cu₃N and Cu₃PdN nanocrystals,”
    <i>Angewandte Chemie - International Edition</i>, vol. 61, no. 31. Wiley, 2022.
  ista: Parvizian M, Duràn Balsa A, Pokratath R, Kalha C, Lee S, Van Den Eynden D,
    Ibáñez M, Regoutz A, De Roo J. 2022. The chemistry of Cu₃N and Cu₃PdN nanocrystals.
    Angewandte Chemie - International Edition. 61(31), e202207013.
  mla: Parvizian, Mahsa, et al. “The Chemistry of Cu₃N and Cu₃PdN Nanocrystals.” <i>Angewandte
    Chemie - International Edition</i>, vol. 61, no. 31, e202207013, Wiley, 2022,
    doi:<a href="https://doi.org/10.1002/anie.202207013">10.1002/anie.202207013</a>.
  short: M. Parvizian, A. Duràn Balsa, R. Pokratath, C. Kalha, S. Lee, D. Van Den
    Eynden, M. Ibáñez, A. Regoutz, J. De Roo, Angewandte Chemie - International Edition
    61 (2022).
date_created: 2022-06-19T22:01:58Z
date_published: 2022-08-01T00:00:00Z
date_updated: 2023-08-03T07:19:12Z
day: '01'
ddc:
- '540'
department:
- _id: MaIb
doi: 10.1002/anie.202207013
external_id:
  isi:
  - '000811084000001'
  pmid:
  - '35612297'
file:
- access_level: open_access
  checksum: 2a3ee0bb59e044b808ebe85cd94ac899
  content_type: application/pdf
  creator: dernst
  date_created: 2022-07-29T09:29:20Z
  date_updated: 2022-07-29T09:29:20Z
  file_id: '11696'
  file_name: 2022_AngewandteChemieInternat_Parvizian.pdf
  file_size: 1303202
  relation: main_file
  success: 1
file_date_updated: 2022-07-29T09:29:20Z
has_accepted_license: '1'
intvolume: '        61'
isi: 1
issue: '31'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Angewandte Chemie - International Edition
publication_identifier:
  eissn:
  - 1521-3773
  issn:
  - 1433-7851
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
  record:
  - id: '11695'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: The chemistry of Cu₃N and Cu₃PdN nanocrystals
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 61
year: '2022'
...
---
_id: '11456'
abstract:
- lang: eng
  text: The proteomes of specialized structures, and the interactomes of proteins
    of interest, provide entry points to elucidate the functions of molecular machines.
    Here, we review a proximity-labeling strategy that uses the improved E. coli biotin
    ligase TurboID to characterize C. elegans protein complexes. Although the focus
    is on C. elegans neurons, the method is applicable regardless of cell type. We
    describe detailed extraction procedures that solubilize the bulk of C. elegans
    proteins and highlight the importance of tagging endogenous genes, to ensure physiological
    expression levels. We review issues associated with non-specific background noise
    and the importance of appropriate controls. As proof of principle, we review our
    analysis of the interactome of a presynaptic active zone protein, ELKS-1. Our
    aim is to provide a detailed protocol for TurboID-based proximity labeling in
    C. elegans and to highlight its potential and its limitations to characterize
    protein complexes and subcellular compartments in this animal.
acknowledgement: We thank de Bono lab members for the helpful comments on the manuscript.
  The biotin-auxotrophic E. coli strain MG1655bioB:kan was a generous gift from J.
  Cronan (University of Illinois) and was kindly sent to us by Jessica Feldman and
  Ariana Sanchez (Stanford University). dg398 pEntryslot2_mNeongreen::3XFLAG::stop
  and dg397 pEntryslot3_mNeongreen::3XFLAG::stop::unc-54 3’UTR entry vector were kindly
  sent by Dr. Dominique Glauser (University of Fribourg). This work was supported
  by an Advanced ERC Grant (269058 ACMO) and a Wellcome Investigator Award (209504/Z/17/Z)
  to MdB and an ISTplus Fellowship to MA (Marie Sklodowska-Curie agreement No 754411).
alternative_title:
- Neuromethods
article_processing_charge: No
author:
- first_name: Murat
  full_name: Artan, Murat
  id: C407B586-6052-11E9-B3AE-7006E6697425
  last_name: Artan
  orcid: 0000-0001-8945-6992
- first_name: Mario
  full_name: de Bono, Mario
  id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
  last_name: de Bono
  orcid: 0000-0001-8347-0443
citation:
  ama: 'Artan M, de Bono M. Proteomic Analysis of C. Elegans Neurons Using TurboID-Based
    Proximity Labeling. In: Yamamoto D, ed. <i>Behavioral Neurogenetics</i>. Vol 181.
    NM. New York: Springer Nature; 2022:277-294. doi:<a href="https://doi.org/10.1007/978-1-0716-2321-3_15">10.1007/978-1-0716-2321-3_15</a>'
  apa: 'Artan, M., &#38; de Bono, M. (2022). Proteomic Analysis of C. Elegans Neurons
    Using TurboID-Based Proximity Labeling. In D. Yamamoto (Ed.), <i>Behavioral Neurogenetics</i>
    (Vol. 181, pp. 277–294). New York: Springer Nature. <a href="https://doi.org/10.1007/978-1-0716-2321-3_15">https://doi.org/10.1007/978-1-0716-2321-3_15</a>'
  chicago: 'Artan, Murat, and Mario de Bono. “Proteomic Analysis of C. Elegans Neurons
    Using TurboID-Based Proximity Labeling.” In <i>Behavioral Neurogenetics</i>, edited
    by Daisuke Yamamoto, 181:277–94. NM. New York: Springer Nature, 2022. <a href="https://doi.org/10.1007/978-1-0716-2321-3_15">https://doi.org/10.1007/978-1-0716-2321-3_15</a>.'
  ieee: 'M. Artan and M. de Bono, “Proteomic Analysis of C. Elegans Neurons Using
    TurboID-Based Proximity Labeling,” in <i>Behavioral Neurogenetics</i>, vol. 181,
    D. Yamamoto, Ed. New York: Springer Nature, 2022, pp. 277–294.'
  ista: 'Artan M, de Bono M. 2022.Proteomic Analysis of C. Elegans Neurons Using TurboID-Based
    Proximity Labeling. In: Behavioral Neurogenetics. Neuromethods, vol. 181, 277–294.'
  mla: Artan, Murat, and Mario de Bono. “Proteomic Analysis of C. Elegans Neurons
    Using TurboID-Based Proximity Labeling.” <i>Behavioral Neurogenetics</i>, edited
    by Daisuke Yamamoto, vol. 181, Springer Nature, 2022, pp. 277–94, doi:<a href="https://doi.org/10.1007/978-1-0716-2321-3_15">10.1007/978-1-0716-2321-3_15</a>.
  short: M. Artan, M. de Bono, in:, D. Yamamoto (Ed.), Behavioral Neurogenetics, Springer
    Nature, New York, 2022, pp. 277–294.
corr_author: '1'
date_created: 2022-06-20T08:10:34Z
date_published: 2022-06-04T00:00:00Z
date_updated: 2025-04-14T07:43:58Z
day: '04'
department:
- _id: MaDe
doi: 10.1007/978-1-0716-2321-3_15
ec_funded: 1
editor:
- first_name: Daisuke
  full_name: Yamamoto, Daisuke
  last_name: Yamamoto
intvolume: '       181'
language:
- iso: eng
month: '06'
oa_version: None
page: 277-294
place: New York
project:
- _id: 23870BE8-32DE-11EA-91FC-C7463DDC885E
  grant_number: 209504/A/17/Z
  name: Molecular mechanisms of neural circuit function
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: Behavioral Neurogenetics
publication_identifier:
  eisbn:
  - '9781071623213'
  eissn:
  - 1940-6045
  isbn:
  - '9781071623206'
  issn:
  - 0893-2336
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
series_title: NM
status: public
title: Proteomic Analysis of C. Elegans Neurons Using TurboID-Based Proximity Labeling
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 181
year: '2022'
...
---
_id: '11459'
abstract:
- lang: eng
  text: 'We present a novel approach to differential cost analysis that, given a program
    revision, attempts to statically bound the difference in resource usage, or cost,
    between the two program versions. Differential cost analysis is particularly interesting
    because of the many compelling applications for it, such as detecting resource-use
    regressions at code-review time or proving the absence of certain side-channel
    vulnerabilities. One prior approach to differential cost analysis is to apply
    relational reasoning that conceptually constructs a product program on which one
    can over-approximate the difference in costs between the two program versions.
    However, a significant challenge in any relational approach is effectively aligning
    the program versions to get precise results. In this paper, our key insight is
    that we can avoid the need for and the limitations of program alignment if, instead,
    we bound the difference of two cost-bound summaries rather than directly bounding
    the concrete cost difference. In particular, our method computes a threshold value
    for the maximal difference in cost between two program versions simultaneously
    using two kinds of cost-bound summaries---a potential function that evaluates
    to an upper bound for the cost incurred in the first program and an anti-potential
    function that evaluates to a lower bound for the cost incurred in the second.
    Our method has a number of desirable properties: it can be fully automated, it
    allows optimizing the threshold value on relative cost, it is suitable for programs
    that are not syntactically similar, and it supports non-determinism. We have evaluated
    an implementation of our approach on a number of program pairs collected from
    the literature, and we find that our method computes tight threshold values on
    relative cost in most examples.'
acknowledgement: "We thank Shaun Willows, Thomas Lugnet, and the Living Room Application
  Vending team for suggesting threshold\r\nbounds as a developer-friendly way to interact
  with a differential cost analyzer, and we thank Jim Christy, Daniel\r\nSchoepe,
  and the Prime Video Automated Reasoning team for their support and helpful suggestions
  throughout the\r\nproject. We also thank Michael Emmi for feedback on an earlier
  version of this paper. And finally, we thank the anonymous reviewers for their useful
  feedback and Aws Albarghouthi for shepherding the final version of the paper. Ðorđe
  Žikelić was also partially supported by ERC CoG 863818 (FoRM-SMArt)."
article_processing_charge: No
arxiv: 1
author:
- first_name: Dorde
  full_name: Zikelic, Dorde
  id: 294AA7A6-F248-11E8-B48F-1D18A9856A87
  last_name: Zikelic
  orcid: 0000-0002-4681-1699
- first_name: Bor-Yuh Evan
  full_name: Chang, Bor-Yuh Evan
  last_name: Chang
- first_name: Pauline
  full_name: Bolignano, Pauline
  last_name: Bolignano
- first_name: Franco
  full_name: Raimondi, Franco
  last_name: Raimondi
citation:
  ama: 'Zikelic D, Chang B-YE, Bolignano P, Raimondi F. Differential cost analysis
    with simultaneous potentials and anti-potentials. In: <i>Proceedings of the 43rd
    ACM SIGPLAN International Conference on Programming Language Design and Implementation</i>.
    Association for Computing Machinery; 2022:442-457. doi:<a href="https://doi.org/10.1145/3519939.3523435">10.1145/3519939.3523435</a>'
  apa: 'Zikelic, D., Chang, B.-Y. E., Bolignano, P., &#38; Raimondi, F. (2022). Differential
    cost analysis with simultaneous potentials and anti-potentials. In <i>Proceedings
    of the 43rd ACM SIGPLAN International Conference on Programming Language Design
    and Implementation</i> (pp. 442–457). San Diego, CA, United States: Association
    for Computing Machinery. <a href="https://doi.org/10.1145/3519939.3523435">https://doi.org/10.1145/3519939.3523435</a>'
  chicago: Zikelic, Dorde, Bor-Yuh Evan Chang, Pauline Bolignano, and Franco Raimondi.
    “Differential Cost Analysis with Simultaneous Potentials and Anti-Potentials.”
    In <i>Proceedings of the 43rd ACM SIGPLAN International Conference on Programming
    Language Design and Implementation</i>, 442–57. Association for Computing Machinery,
    2022. <a href="https://doi.org/10.1145/3519939.3523435">https://doi.org/10.1145/3519939.3523435</a>.
  ieee: D. Zikelic, B.-Y. E. Chang, P. Bolignano, and F. Raimondi, “Differential cost
    analysis with simultaneous potentials and anti-potentials,” in <i>Proceedings
    of the 43rd ACM SIGPLAN International Conference on Programming Language Design
    and Implementation</i>, San Diego, CA, United States, 2022, pp. 442–457.
  ista: 'Zikelic D, Chang B-YE, Bolignano P, Raimondi F. 2022. Differential cost analysis
    with simultaneous potentials and anti-potentials. Proceedings of the 43rd ACM
    SIGPLAN International Conference on Programming Language Design and Implementation.
    PLDI: Programming Language Design and Implementation, 442–457.'
  mla: Zikelic, Dorde, et al. “Differential Cost Analysis with Simultaneous Potentials
    and Anti-Potentials.” <i>Proceedings of the 43rd ACM SIGPLAN International Conference
    on Programming Language Design and Implementation</i>, Association for Computing
    Machinery, 2022, pp. 442–57, doi:<a href="https://doi.org/10.1145/3519939.3523435">10.1145/3519939.3523435</a>.
  short: D. Zikelic, B.-Y.E. Chang, P. Bolignano, F. Raimondi, in:, Proceedings of
    the 43rd ACM SIGPLAN International Conference on Programming Language Design and
    Implementation, Association for Computing Machinery, 2022, pp. 442–457.
conference:
  end_date: 2022-06-17
  location: San Diego, CA, United States
  name: 'PLDI: Programming Language Design and Implementation'
  start_date: 2022-06-13
corr_author: '1'
date_created: 2022-06-21T09:26:15Z
date_published: 2022-06-09T00:00:00Z
date_updated: 2025-04-14T07:52:47Z
day: '09'
ddc:
- '000'
department:
- _id: GradSch
- _id: KrCh
doi: 10.1145/3519939.3523435
ec_funded: 1
external_id:
  arxiv:
  - '2204.00870'
  isi:
  - '000850435600030'
file:
- access_level: open_access
  checksum: 7eb915a2ca5b5ce4729321f33b2e16e1
  content_type: application/pdf
  creator: dernst
  date_created: 2022-06-27T07:38:21Z
  date_updated: 2022-06-27T07:38:21Z
  file_id: '11466'
  file_name: 2022_PLDI_Zikelic.pdf
  file_size: 318697
  relation: main_file
  success: 1
file_date_updated: 2022-06-27T07:38:21Z
has_accepted_license: '1'
isi: 1
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 442-457
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
  call_identifier: H2020
  grant_number: '863818'
  name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
publication: Proceedings of the 43rd ACM SIGPLAN International Conference on Programming
  Language Design and Implementation
publication_identifier:
  isbn:
  - '9781450392655'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential cost analysis with simultaneous potentials and anti-potentials
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
year: '2022'
...
---
_id: '11460'
abstract:
- lang: eng
  text: "Background: Proper cerebral cortical development depends on the tightly orchestrated
    migration of newly born neurons from the inner ventricular and subventricular
    zones to the outer cortical plate. Any disturbance in this process during prenatal
    stages may lead to neuronal migration disorders (NMDs), which can vary in extent
    from focal to global. Furthermore, NMDs show a substantial comorbidity with other
    neurodevelopmental disorders, notably autism spectrum disorders (ASDs). Our previous
    work demonstrated focal neuronal migration defects in mice carrying loss-of-function
    alleles of the recognized autism risk gene WDFY3. However, the cellular origins
    of these defects in Wdfy3 mutant mice remain elusive and uncovering it will provide
    critical insight into WDFY3-dependent disease pathology.\r\nMethods: Here, in
    an effort to untangle the origins of NMDs in Wdfy3lacZ mice, we employed mosaic
    analysis with double markers (MADM). MADM technology enabled us to genetically
    distinctly track and phenotypically analyze mutant and wild-type cells concomitantly
    in vivo using immunofluorescent techniques.\r\nResults: We revealed a cell autonomous
    requirement of WDFY3 for accurate laminar positioning of cortical projection neurons
    and elimination of mispositioned cells during early postnatal life. In addition,
    we identified significant deviations in dendritic arborization, as well as synaptic
    density and morphology between wild type, heterozygous, and homozygous Wdfy3 mutant
    neurons in Wdfy3-MADM reporter mice at postnatal stages.\r\nLimitations: While
    Wdfy3 mutant mice have provided valuable insight into prenatal aspects of ASD
    pathology that remain inaccessible to investigation in humans, like most animal
    models, they do not a perfectly replicate all aspects of human ASD biology. The
    lack of human data makes it indeterminate whether morphological deviations described
    here apply to ASD patients or some of the other neurodevelopmental conditions
    associated with WDFY3 mutation.\r\nConclusions: Our genetic approach revealed
    several cell autonomous requirements of WDFY3 in neuronal development that could
    underlie the pathogenic mechanisms of WDFY3-related neurodevelopmental conditions.
    The results are also consistent with findings in other ASD animal models and patients
    and suggest an important role for WDFY3 in regulating neuronal function and interconnectivity
    in postnatal life."
acknowledgement: "This study was funded by NIMH R21MH115347 to KSZ. KSZ is further
  supported by Shriners Hospitals for Children.\r\nWe would like to thank Angelo Harlan
  de Crescenzo for early contributions to this project."
article_number: '27'
article_processing_charge: No
article_type: original
author:
- first_name: Zachary A.
  full_name: Schaaf, Zachary A.
  last_name: Schaaf
- first_name: Lyvin
  full_name: Tat, Lyvin
  last_name: Tat
- first_name: Noemi
  full_name: Cannizzaro, Noemi
  last_name: Cannizzaro
- first_name: Ralph
  full_name: Green, Ralph
  last_name: Green
- first_name: Thomas
  full_name: Rülicke, Thomas
  last_name: Rülicke
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: Konstantinos S.
  full_name: Zarbalis, Konstantinos S.
  last_name: Zarbalis
citation:
  ama: Schaaf ZA, Tat L, Cannizzaro N, et al. WDFY3 mutation alters laminar position
    and morphology of cortical neurons. <i>Molecular Autism</i>. 2022;13. doi:<a href="https://doi.org/10.1186/s13229-022-00508-3">10.1186/s13229-022-00508-3</a>
  apa: Schaaf, Z. A., Tat, L., Cannizzaro, N., Green, R., Rülicke, T., Hippenmeyer,
    S., &#38; Zarbalis, K. S. (2022). WDFY3 mutation alters laminar position and morphology
    of cortical neurons. <i>Molecular Autism</i>. Springer Nature. <a href="https://doi.org/10.1186/s13229-022-00508-3">https://doi.org/10.1186/s13229-022-00508-3</a>
  chicago: Schaaf, Zachary A., Lyvin Tat, Noemi Cannizzaro, Ralph Green, Thomas Rülicke,
    Simon Hippenmeyer, and Konstantinos S. Zarbalis. “WDFY3 Mutation Alters Laminar
    Position and Morphology of Cortical Neurons.” <i>Molecular Autism</i>. Springer
    Nature, 2022. <a href="https://doi.org/10.1186/s13229-022-00508-3">https://doi.org/10.1186/s13229-022-00508-3</a>.
  ieee: Z. A. Schaaf <i>et al.</i>, “WDFY3 mutation alters laminar position and morphology
    of cortical neurons,” <i>Molecular Autism</i>, vol. 13. Springer Nature, 2022.
  ista: Schaaf ZA, Tat L, Cannizzaro N, Green R, Rülicke T, Hippenmeyer S, Zarbalis
    KS. 2022. WDFY3 mutation alters laminar position and morphology of cortical neurons.
    Molecular Autism. 13, 27.
  mla: Schaaf, Zachary A., et al. “WDFY3 Mutation Alters Laminar Position and Morphology
    of Cortical Neurons.” <i>Molecular Autism</i>, vol. 13, 27, Springer Nature, 2022,
    doi:<a href="https://doi.org/10.1186/s13229-022-00508-3">10.1186/s13229-022-00508-3</a>.
  short: Z.A. Schaaf, L. Tat, N. Cannizzaro, R. Green, T. Rülicke, S. Hippenmeyer,
    K.S. Zarbalis, Molecular Autism 13 (2022).
date_created: 2022-06-23T14:28:55Z
date_published: 2022-06-22T00:00:00Z
date_updated: 2025-06-11T13:34:57Z
day: '22'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1186/s13229-022-00508-3
external_id:
  isi:
  - '000814641400001'
  pmid:
  - '35733184'
file:
- access_level: open_access
  checksum: 525d2618e855139089bbfc3e3d49d1b2
  content_type: application/pdf
  creator: dernst
  date_created: 2022-06-24T08:22:59Z
  date_updated: 2022-06-24T08:22:59Z
  file_id: '11461'
  file_name: 2022_MolecularAutism_Schaaf.pdf
  file_size: 7552298
  relation: main_file
  success: 1
file_date_updated: 2022-06-24T08:22:59Z
has_accepted_license: '1'
intvolume: '        13'
isi: 1
keyword:
- Psychiatry and Mental health
- Developmental Biology
- Developmental Neuroscience
- Molecular Biology
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
publication: Molecular Autism
publication_identifier:
  issn:
  - 2040-2392
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - relation: erratum
    url: https://doi.org/10.1186/s13229-023-00539-4
scopus_import: '1'
status: public
title: WDFY3 mutation alters laminar position and morphology of cortical neurons
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2022'
...
---
_id: '11462'
abstract:
- lang: eng
  text: Nanobodies (VHH) from camelid antibody libraries hold great promise as therapeutic
    agents and components of immunoassay systems. Synthetic antibody libraries that
    could be designed and generated once and for various applications could yield
    binders to virtually any targets, even for non-immunogenic or toxic ones, in a
    short term. One of the most difficult tasks is to obtain antibodies with a high
    affinity and specificity to polyglycosylated proteins. It requires antibody libraries
    with extremely high functional diversity and the use of sophisticated selection
    techniques. Here we report a development of a novel sandwich immunoassay involving
    a combination of the synthetic library-derived VHH-Fc fusion protein as a capture
    antibody and the immune single-chain fragment variable (scFv) as a tracer for
    the detection of pregnancy-associated glycoprotein (PAG) of cattle (Bos taurus).
    We succeeded in the generation of a number of specific scFv antibodies against
    PAG from the mouse immune library. Subsequent selection using the immobilized
    scFv-Fc capture antibody allowed to isolate 1.9 nM VHH binder from the diverse
    synthetic library without any overlapping with the capture antibody binding site.
    The prototype sandwich ELISA based on the synthetic VHH and the immune scFv was
    established. This is the first successful example of the combination of synthetic
    and immune antibody libraries in a single sandwich immunoassay. Thus, our approach
    could be used for the express isolation of antibody pairs and the development
    of sandwich immunoassays for challenging antigens.
acknowledgement: This study was financially supported by the State Committee on Science
  and Technology. We would like to thank Elena Tumar and Elena Kisileva at the Institute
  of Bioorganic Chemistry of NASB for their kind assistance with mouse immunizations.
article_processing_charge: No
article_type: original
author:
- first_name: Dmitri
  full_name: Dormeshkin, Dmitri
  last_name: Dormeshkin
- first_name: Michail
  full_name: Shapira, Michail
  last_name: Shapira
- first_name: Alena
  full_name: Karputs, Alena
  last_name: Karputs
- first_name: Anton
  full_name: Kavaleuski, Anton
  id: 62304f89-eb97-11eb-a6c2-8903dd183976
  last_name: Kavaleuski
  orcid: 0000-0003-2091-526X
- first_name: Ivan
  full_name: Kuzminski, Ivan
  last_name: Kuzminski
- first_name: Elena
  full_name: Stepanova, Elena
  last_name: Stepanova
- first_name: Andrei
  full_name: Gilep, Andrei
  last_name: Gilep
citation:
  ama: Dormeshkin D, Shapira M, Karputs A, et al. Combining of synthetic VHH and immune
    scFv libraries for pregnancy-associated glycoproteins ELISA development. <i>Applied
    Microbiology and Biotechnology</i>. 2022;106:5093-5103. doi:<a href="https://doi.org/10.1007/s00253-022-12022-w">10.1007/s00253-022-12022-w</a>
  apa: Dormeshkin, D., Shapira, M., Karputs, A., Kavaleuski, A., Kuzminski, I., Stepanova,
    E., &#38; Gilep, A. (2022). Combining of synthetic VHH and immune scFv libraries
    for pregnancy-associated glycoproteins ELISA development. <i>Applied Microbiology
    and Biotechnology</i>. Springer Nature. <a href="https://doi.org/10.1007/s00253-022-12022-w">https://doi.org/10.1007/s00253-022-12022-w</a>
  chicago: Dormeshkin, Dmitri, Michail Shapira, Alena Karputs, Anton Kavaleuski, Ivan
    Kuzminski, Elena Stepanova, and Andrei Gilep. “Combining of Synthetic VHH and
    Immune ScFv Libraries for Pregnancy-Associated Glycoproteins ELISA Development.”
    <i>Applied Microbiology and Biotechnology</i>. Springer Nature, 2022. <a href="https://doi.org/10.1007/s00253-022-12022-w">https://doi.org/10.1007/s00253-022-12022-w</a>.
  ieee: D. Dormeshkin <i>et al.</i>, “Combining of synthetic VHH and immune scFv libraries
    for pregnancy-associated glycoproteins ELISA development,” <i>Applied Microbiology
    and Biotechnology</i>, vol. 106. Springer Nature, pp. 5093–5103, 2022.
  ista: Dormeshkin D, Shapira M, Karputs A, Kavaleuski A, Kuzminski I, Stepanova E,
    Gilep A. 2022. Combining of synthetic VHH and immune scFv libraries for pregnancy-associated
    glycoproteins ELISA development. Applied Microbiology and Biotechnology. 106,
    5093–5103.
  mla: Dormeshkin, Dmitri, et al. “Combining of Synthetic VHH and Immune ScFv Libraries
    for Pregnancy-Associated Glycoproteins ELISA Development.” <i>Applied Microbiology
    and Biotechnology</i>, vol. 106, Springer Nature, 2022, pp. 5093–103, doi:<a href="https://doi.org/10.1007/s00253-022-12022-w">10.1007/s00253-022-12022-w</a>.
  short: D. Dormeshkin, M. Shapira, A. Karputs, A. Kavaleuski, I. Kuzminski, E. Stepanova,
    A. Gilep, Applied Microbiology and Biotechnology 106 (2022) 5093–5103.
date_created: 2022-06-26T22:01:34Z
date_published: 2022-08-01T00:00:00Z
date_updated: 2023-10-10T07:15:02Z
day: '01'
department:
- _id: GradSch
- _id: LeSa
doi: 10.1007/s00253-022-12022-w
external_id:
  isi:
  - '000813677500001'
  pmid:
  - '35723693'
intvolume: '       106'
isi: 1
language:
- iso: eng
month: '08'
oa_version: None
page: 5093-5103
pmid: 1
publication: Applied Microbiology and Biotechnology
publication_identifier:
  eissn:
  - 1432-0614
  issn:
  - 0175-7598
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Combining of synthetic VHH and immune scFv libraries for pregnancy-associated
  glycoproteins ELISA development
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 106
year: '2022'
...
---
_id: '11488'
abstract:
- lang: eng
  text: Hydrogen Lyα haloes (LAHs) are commonly used as a tracer of the circumgalactic
    medium (CGM) at high redshifts. In this work, we aim to explore the existence
    of Lyα haloes around individual UV-selected galaxies, rather than around Lyα emitters
    (LAEs), at high redshifts. Our sample was continuum-selected with F775W ≤ 27.5,
    and spectroscopic redshifts were assigned or constrained for all the sources thanks
    to the deepest (100- to 140-h) existing Very Large Telescope (VLT)/Multi-Unit
    Spectroscopic Explorer (MUSE) data with adaptive optics. The final sample includes
    21 galaxies that are purely F775W-magnitude selected within the redshift range
    z ≈ 2.9 − 4.4 and within a UV magnitude range −20 ≤ M1500 ≤ −18, thus avoiding
    any bias toward LAEs. We tested whether galaxy’s Lyα emission is significantly
    more extended than the MUSE PSF-convolved continuum component. We find 17 LAHs
    and four non-LAHs. We report the first individual detections of extended Lyα emission
    around non-LAEs. The Lyα halo fraction is thus as high as 81.0−11.2+10.3%, which
    is close to that for LAEs at z = 3 − 6 in the literature. This implies that UV-selected
    galaxies generally have a large amount of hydrogen in their CGM. We derived the
    mean surface brightness (SB) profile for our LAHs with cosmic dimming corrections
    and find that Lyα emission extends to 5.4 arcsec (≃40 physical kpc at the midpoint
    redshift z = 3.6) above the typical 1σ SB limit. The incidence rate of surrounding
    gas detected in Lyα per one-dimensional line of sight per unit redshift, dn/dz,
    is estimated to be 0.76−0.09+0.09 for galaxies with M1500 ≤ −18 mag at z ≃ 3.7.
    Assuming that Lyα emission and absorption arise in the same gas, this suggests,
    based on abundance matching, that LAHs trace the same gas as damped Lyα systems
    (DLAs) and sub-DLAs.
acknowledgement: 'We thank the anonymous referee for constructive comments and suggestions.
  We would like to express our gratitude to Edmund Christian Herenz, Leindert Boogard,
  Miroslava Dessauges, Moupiya Maji, Valentin Mauerhofer, Charlotte Paola Simmonds
  Wagemann, Masami Ouchi, Kazuhiro Shimasaku, Akio Inoue, and Rieko Momose for giving
  insightful comments and suggestions. H.K. is grateful to Liam McCarney for useful
  suggestions on English writing through the UniGE’s Tandems linguistiques. H.K. acknowledges
  support from Swiss Government Excellence Scholarships and Japan Society for the
  Promotion of Science (JSPS) Overseas Research Fellowship. H.K., F.L., and A.V. are
  supported by the SNF grant PP00P2 176808. A.V. and T.G. are supported by the ERC
  Starting Grant 757258“TRIPLE”. This work was supported by the Programme National
  Cosmology et Galaxies (PNCG) of CNRS/INSU with INP and IN2P3, co-funded by CEA and
  CNES. This work is based on observations taken by VLT, which is operated by European
  Southern Observatory. This research made use of Astropy, which is a community-developed
  core Python package for Astronomy (Astropy Collaboration 2013, 2018), and other
  software and packages: MARZ, MPDAF (Piqueras et al. 2019), PHOTUTILS, Numpy (Harris
  et al. 2020), Scipy (Virtanen et al. 2020), and matplotlib (Hunter 2007).'
article_number: A44
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Haruka
  full_name: Kusakabe, Haruka
  last_name: Kusakabe
- first_name: Anne
  full_name: Verhamme, Anne
  last_name: Verhamme
- first_name: Jérémy
  full_name: Blaizot, Jérémy
  last_name: Blaizot
- first_name: Thibault
  full_name: Garel, Thibault
  last_name: Garel
- first_name: Lutz
  full_name: Wisotzki, Lutz
  last_name: Wisotzki
- first_name: Floriane
  full_name: Leclercq, Floriane
  last_name: Leclercq
- first_name: Roland
  full_name: Bacon, Roland
  last_name: Bacon
- first_name: Joop
  full_name: Schaye, Joop
  last_name: Schaye
- first_name: Sofia G.
  full_name: Gallego, Sofia G.
  last_name: Gallego
- first_name: Josephine
  full_name: Kerutt, Josephine
  last_name: Kerutt
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
- first_name: Michael
  full_name: Maseda, Michael
  last_name: Maseda
- first_name: Themiya
  full_name: Nanayakkara, Themiya
  last_name: Nanayakkara
- first_name: Roser
  full_name: Pelló, Roser
  last_name: Pelló
- first_name: Johan
  full_name: Richard, Johan
  last_name: Richard
- first_name: Laurence
  full_name: Tresse, Laurence
  last_name: Tresse
- first_name: Tanya
  full_name: Urrutia, Tanya
  last_name: Urrutia
- first_name: Eloïse
  full_name: Vitte, Eloïse
  last_name: Vitte
citation:
  ama: 'Kusakabe H, Verhamme A, Blaizot J, et al. The MUSE eXtremely Deep Field: Individual
    detections of Ly<i>α</i> haloes around rest-frame UV-selected galaxies at <i>z</i>
    ≃ 2.9–4.4. <i>Astronomy &#38; Astrophysics</i>. 2022;660. doi:<a href="https://doi.org/10.1051/0004-6361/202142302">10.1051/0004-6361/202142302</a>'
  apa: 'Kusakabe, H., Verhamme, A., Blaizot, J., Garel, T., Wisotzki, L., Leclercq,
    F., … Vitte, E. (2022). The MUSE eXtremely Deep Field: Individual detections of
    Ly<i>α</i> haloes around rest-frame UV-selected galaxies at <i>z</i> ≃ 2.9–4.4.
    <i>Astronomy &#38; Astrophysics</i>. EDP Sciences. <a href="https://doi.org/10.1051/0004-6361/202142302">https://doi.org/10.1051/0004-6361/202142302</a>'
  chicago: 'Kusakabe, Haruka, Anne Verhamme, Jérémy Blaizot, Thibault Garel, Lutz
    Wisotzki, Floriane Leclercq, Roland Bacon, et al. “The MUSE EXtremely Deep Field:
    Individual Detections of Ly<i>α</i> Haloes around Rest-Frame UV-Selected Galaxies
    at <i>z</i> ≃ 2.9–4.4.” <i>Astronomy &#38; Astrophysics</i>. EDP Sciences, 2022.
    <a href="https://doi.org/10.1051/0004-6361/202142302">https://doi.org/10.1051/0004-6361/202142302</a>.'
  ieee: 'H. Kusakabe <i>et al.</i>, “The MUSE eXtremely Deep Field: Individual detections
    of Ly<i>α</i> haloes around rest-frame UV-selected galaxies at <i>z</i> ≃ 2.9–4.4,”
    <i>Astronomy &#38; Astrophysics</i>, vol. 660. EDP Sciences, 2022.'
  ista: 'Kusakabe H, Verhamme A, Blaizot J, Garel T, Wisotzki L, Leclercq F, Bacon
    R, Schaye J, Gallego SG, Kerutt J, Matthee JJ, Maseda M, Nanayakkara T, Pelló
    R, Richard J, Tresse L, Urrutia T, Vitte E. 2022. The MUSE eXtremely Deep Field:
    Individual detections of Ly<i>α</i> haloes around rest-frame UV-selected galaxies
    at <i>z</i> ≃ 2.9–4.4. Astronomy &#38; Astrophysics. 660, A44.'
  mla: 'Kusakabe, Haruka, et al. “The MUSE EXtremely Deep Field: Individual Detections
    of Ly<i>α</i> Haloes around Rest-Frame UV-Selected Galaxies at <i>z</i> ≃ 2.9–4.4.”
    <i>Astronomy &#38; Astrophysics</i>, vol. 660, A44, EDP Sciences, 2022, doi:<a
    href="https://doi.org/10.1051/0004-6361/202142302">10.1051/0004-6361/202142302</a>.'
  short: H. Kusakabe, A. Verhamme, J. Blaizot, T. Garel, L. Wisotzki, F. Leclercq,
    R. Bacon, J. Schaye, S.G. Gallego, J. Kerutt, J.J. Matthee, M. Maseda, T. Nanayakkara,
    R. Pelló, J. Richard, L. Tresse, T. Urrutia, E. Vitte, Astronomy &#38; Astrophysics
    660 (2022).
date_created: 2022-07-05T14:27:26Z
date_published: 2022-04-07T00:00:00Z
date_updated: 2022-07-19T09:33:24Z
day: '07'
doi: 10.1051/0004-6361/202142302
extern: '1'
external_id:
  arxiv:
  - '2201.07257'
intvolume: '       660'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: high-redshift / galaxies: formation / galaxies: evolution / cosmology:
  observations'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2201.07257
month: '04'
oa: 1
oa_version: Published Version
publication: Astronomy & Astrophysics
publication_identifier:
  eissn:
  - 1432-0746
  issn:
  - 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The MUSE eXtremely Deep Field: Individual detections of Ly<i>α</i> haloes
  around rest-frame UV-selected galaxies at <i>z</i> ≃ 2.9–4.4'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 660
year: '2022'
...
---
_id: '11489'
abstract:
- lang: eng
  text: Much of plant development depends on cell-to-cell redistribution of the plant
    hormone auxin, which is facilitated by the plasma membrane (PM) localized PIN
    FORMED (PIN) proteins. Auxin export activity, developmental roles, subcellular
    trafficking, and polarity of PINs have been well studied, but their structure
    remains elusive besides a rough outline that they contain two groups of 5 alpha-helices
    connected by a large hydrophilic loop (HL). Here, we focus on the PIN1 HL as we
    could produce it in sufficient quantities for biochemical investigations to provide
    insights into its secondary structure. Circular dichroism (CD) studies revealed
    its nature as an intrinsically disordered protein (IDP), manifested by the increase
    of structure content upon thermal melting. Consistent with IDPs serving as interaction
    platforms, PIN1 loops homodimerize. PIN1 HL cytoplasmic overexpression in Arabidopsis
    disrupts early endocytic trafficking of PIN1 and PIN2 and causes defects in the
    cotyledon vasculature formation. In summary, we demonstrate that PIN1 HL has an
    intrinsically disordered nature, which must be considered to gain further structural
    insights. Some secondary structures may form transiently during pairing with known
    and yet-to-be-discovered interactors.
acknowledgement: 'We thank Charo del Genio from Coventry University and Richard Napier
  from the University of Warwick for helpful discussion concerning protein modeling
  and inspiration concerning CD spectroscopy, respectively. We thank Jan Hejatko for
  sharing the published AHP2 construct. We also thank Josef Houser from the core facility
  BIC CEITEC for valuable assistance, discussions, and ideas relating to CD. We acknowledge
  the: Core Facility CELLIM of CEITEC supported by the Czech-BioImaging large RI project
  (LM2018129 funded by MEYS CR), part of the Euro-BioImaging (www.eurobioimaging.eu
  accessed on 1 January 2016) ALM and medical imaging Node (Brno, CZ), CF Biomolecular
  Interactions and Crystallization of CIISB, Instruct-CZ Centre, supported by MEYS
  CR (LM2018127) and European Regional Development Fund-Project “UP CIISB“ (No. CZ.02.1.01/0.0/0.0/18_046/0015974)
  for their support with obtaining scientific data presented in this paper; Plant
  Sciences Core Facility of CEITEC Masaryk University for technical support. Open
  Access Funding by the Austrian Science Fund (FWF).'
article_processing_charge: Yes
article_type: original
author:
- first_name: V
  full_name: Bilanovičová, V
  last_name: Bilanovičová
- first_name: N
  full_name: Rýdza, N
  last_name: Rýdza
- first_name: L
  full_name: Koczka, L
  last_name: Koczka
- first_name: M
  full_name: Hess, M
  last_name: Hess
- first_name: E
  full_name: Feraru, E
  last_name: Feraru
- first_name: Jiří
  full_name: Friml, Jiří
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: T
  full_name: Nodzyński, T
  last_name: Nodzyński
citation:
  ama: Bilanovičová V, Rýdza N, Koczka L, et al. The hydrophilic loop of Arabidopsis
    PIN1 auxin efflux carrier harbors hallmarks of an intrinsically disordered protein.
    <i>International Journal of Molecular Sciences</i>. 2022;23(11):6352. doi:<a href="https://doi.org/10.3390/ijms23116352">10.3390/ijms23116352</a>
  apa: Bilanovičová, V., Rýdza, N., Koczka, L., Hess, M., Feraru, E., Friml, J., &#38;
    Nodzyński, T. (2022). The hydrophilic loop of Arabidopsis PIN1 auxin efflux carrier
    harbors hallmarks of an intrinsically disordered protein. <i>International Journal
    of Molecular Sciences</i>. MDPI. <a href="https://doi.org/10.3390/ijms23116352">https://doi.org/10.3390/ijms23116352</a>
  chicago: Bilanovičová, V, N Rýdza, L Koczka, M Hess, E Feraru, Jiří Friml, and T
    Nodzyński. “The Hydrophilic Loop of Arabidopsis PIN1 Auxin Efflux Carrier Harbors
    Hallmarks of an Intrinsically Disordered Protein.” <i>International Journal of
    Molecular Sciences</i>. MDPI, 2022. <a href="https://doi.org/10.3390/ijms23116352">https://doi.org/10.3390/ijms23116352</a>.
  ieee: V. Bilanovičová <i>et al.</i>, “The hydrophilic loop of Arabidopsis PIN1 auxin
    efflux carrier harbors hallmarks of an intrinsically disordered protein,” <i>International
    Journal of Molecular Sciences</i>, vol. 23, no. 11. MDPI, p. 6352, 2022.
  ista: Bilanovičová V, Rýdza N, Koczka L, Hess M, Feraru E, Friml J, Nodzyński T.
    2022. The hydrophilic loop of Arabidopsis PIN1 auxin efflux carrier harbors hallmarks
    of an intrinsically disordered protein. International Journal of Molecular Sciences.
    23(11), 6352.
  mla: Bilanovičová, V., et al. “The Hydrophilic Loop of Arabidopsis PIN1 Auxin Efflux
    Carrier Harbors Hallmarks of an Intrinsically Disordered Protein.” <i>International
    Journal of Molecular Sciences</i>, vol. 23, no. 11, MDPI, 2022, p. 6352, doi:<a
    href="https://doi.org/10.3390/ijms23116352">10.3390/ijms23116352</a>.
  short: V. Bilanovičová, N. Rýdza, L. Koczka, M. Hess, E. Feraru, J. Friml, T. Nodzyński,
    International Journal of Molecular Sciences 23 (2022) 6352.
corr_author: '1'
date_created: 2022-07-05T15:14:34Z
date_published: 2022-06-06T00:00:00Z
date_updated: 2025-04-15T08:12:07Z
day: '06'
ddc:
- '570'
department:
- _id: JiFr
doi: 10.3390/ijms23116352
external_id:
  isi:
  - '000808733300001'
  pmid:
  - '35683031'
file:
- access_level: open_access
  checksum: e997a57a928ec9d51fad8ce824a05935
  content_type: application/pdf
  creator: cchlebak
  date_created: 2022-07-06T07:36:59Z
  date_updated: 2022-07-06T07:36:59Z
  file_id: '11492'
  file_name: 2022_IntJMolSci_Bilanovicova.pdf
  file_size: 2324542
  relation: main_file
  success: 1
file_date_updated: 2022-07-06T07:36:59Z
has_accepted_license: '1'
intvolume: '        23'
isi: 1
issue: '11'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: '6352'
pmid: 1
project:
- _id: 262EF96E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P29988
  name: RNA-directed DNA methylation in plant development
publication: International Journal of Molecular Sciences
publication_identifier:
  issn:
  - 1422-0067
publication_status: published
publisher: MDPI
quality_controlled: '1'
scopus_import: '1'
status: public
title: The hydrophilic loop of Arabidopsis PIN1 auxin efflux carrier harbors hallmarks
  of an intrinsically disordered protein
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2022'
...
---
_id: '11490'
abstract:
- lang: eng
  text: Directly characterising the first generations of stars in distant galaxies
    is a key quest of observational cosmology. We present a case study of ID53 at
    z = 4.77, the UV-brightest (but L⋆) star-forming galaxy at z > 3 in the MUSE eXtremely
    Deep Field with a mass of ≈109 M⊙. In addition to very strong Lyman-α (Lyα) emission,
    we clearly detect the (stellar) continuum and an N V P Cygni feature, interstellar
    absorption, fine-structure emission and nebular C IV emission lines in the 140
    h spectrum. Continuum emission from two spatially resolved components in Hubble
    Space Telescope data are blended in the MUSE data, but we show that the nebular
    C IV emission originates from a subcomponent of the galaxy. The UV spectrum can
    be fit with recent BPASS stellar population models combined with single-burst
    or continuous star formation histories (SFHs), a standard initial mass function,
    and an attenuation law. Models with a young age and low metallicity (log10(age/yr)
    = 6.5–7.6 and [Z/H] = −2.15 to −1.15) are preferred, but the details depend on
    the assumed SFH. The intrinsic Hα luminosity of the best-fit models is an order
    of magnitude higher than the Hα luminosity inferred from Spitzer/IRAC data, which
    either suggests a high escape fraction of ionising photons, a high relative attenuation
    of nebular to stellar dust, or a complex SFH. The metallicity appears lower than
    the metallicity in more massive galaxies at z = 3 − 5, consistent with the scenario
    according to which younger galaxies have lower metallicities. This chemical immaturity
    likely facilitates Lyα escape, explaining why the Lyα equivalent width is anti-correlated
    with stellar metallicity. Finally, we stress that uncertainties in SFHs impose
    a challenge for future inferences of the stellar metallicity of young galaxies.
    This highlights the need for joint (spatially resolved) analyses of stellar spectra
    and photo-ionisation models.
acknowledgement: We thank the referee for thoughtful and constructive comments that
  have improved the quality of this manuscript. Based on observations collected at
  the European Southern Observatory under ESO programme 1101.A-0127. This work made
  use of v2.2.1 of the Binary Population and Spectral Synthesis (BPASS) models as
  described in Eldridge et al. (2017) and Stanway & Eldridge (2018). A.F. acknowledges
  the support from grant PRIN MIUR2017-20173ML3WW_001. T.N. acknowledges support from
  Australian Research Council Laureate Fellowship FL180100060.
article_number: A10
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
- first_name: Anna
  full_name: Feltre, Anna
  last_name: Feltre
- first_name: Michael
  full_name: Maseda, Michael
  last_name: Maseda
- first_name: Themiya
  full_name: Nanayakkara, Themiya
  last_name: Nanayakkara
- first_name: Leindert
  full_name: Boogaard, Leindert
  last_name: Boogaard
- first_name: Roland
  full_name: Bacon, Roland
  last_name: Bacon
- first_name: Anne
  full_name: Verhamme, Anne
  last_name: Verhamme
- first_name: Floriane
  full_name: Leclercq, Floriane
  last_name: Leclercq
- first_name: Haruka
  full_name: Kusakabe, Haruka
  last_name: Kusakabe
- first_name: Tanya
  full_name: Urrutia, Tanya
  last_name: Urrutia
- first_name: Lutz
  full_name: Wisotzki, Lutz
  last_name: Wisotzki
citation:
  ama: 'Matthee JJ, Feltre A, Maseda M, et al. Deciphering stellar metallicities in
    the early universe: Case study of a young galaxy at z = 4.77 in the MUSE eXtremely
    Deep Field. <i>Astronomy &#38; Astrophysics</i>. 2022;660. doi:<a href="https://doi.org/10.1051/0004-6361/202142187">10.1051/0004-6361/202142187</a>'
  apa: 'Matthee, J. J., Feltre, A., Maseda, M., Nanayakkara, T., Boogaard, L., Bacon,
    R., … Wisotzki, L. (2022). Deciphering stellar metallicities in the early universe:
    Case study of a young galaxy at z = 4.77 in the MUSE eXtremely Deep Field. <i>Astronomy
    &#38; Astrophysics</i>. EDP Sciences. <a href="https://doi.org/10.1051/0004-6361/202142187">https://doi.org/10.1051/0004-6361/202142187</a>'
  chicago: 'Matthee, Jorryt J, Anna Feltre, Michael Maseda, Themiya Nanayakkara, Leindert
    Boogaard, Roland Bacon, Anne Verhamme, et al. “Deciphering Stellar Metallicities
    in the Early Universe: Case Study of a Young Galaxy at z = 4.77 in the MUSE EXtremely
    Deep Field.” <i>Astronomy &#38; Astrophysics</i>. EDP Sciences, 2022. <a href="https://doi.org/10.1051/0004-6361/202142187">https://doi.org/10.1051/0004-6361/202142187</a>.'
  ieee: 'J. J. Matthee <i>et al.</i>, “Deciphering stellar metallicities in the early
    universe: Case study of a young galaxy at z = 4.77 in the MUSE eXtremely Deep
    Field,” <i>Astronomy &#38; Astrophysics</i>, vol. 660. EDP Sciences, 2022.'
  ista: 'Matthee JJ, Feltre A, Maseda M, Nanayakkara T, Boogaard L, Bacon R, Verhamme
    A, Leclercq F, Kusakabe H, Urrutia T, Wisotzki L. 2022. Deciphering stellar metallicities
    in the early universe: Case study of a young galaxy at z = 4.77 in the MUSE eXtremely
    Deep Field. Astronomy &#38; Astrophysics. 660, A10.'
  mla: 'Matthee, Jorryt J., et al. “Deciphering Stellar Metallicities in the Early
    Universe: Case Study of a Young Galaxy at z = 4.77 in the MUSE EXtremely Deep
    Field.” <i>Astronomy &#38; Astrophysics</i>, vol. 660, A10, EDP Sciences, 2022,
    doi:<a href="https://doi.org/10.1051/0004-6361/202142187">10.1051/0004-6361/202142187</a>.'
  short: J.J. Matthee, A. Feltre, M. Maseda, T. Nanayakkara, L. Boogaard, R. Bacon,
    A. Verhamme, F. Leclercq, H. Kusakabe, T. Urrutia, L. Wisotzki, Astronomy &#38;
    Astrophysics 660 (2022).
date_created: 2022-07-05T15:25:35Z
date_published: 2022-03-30T00:00:00Z
date_updated: 2024-10-14T11:31:22Z
day: '30'
doi: 10.1051/0004-6361/202142187
extern: '1'
external_id:
  arxiv:
  - '2111.14855'
intvolume: '       660'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: high-redshift / techniques: spectroscopic / galaxies: stellar content
  / galaxies: formation'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2111.14855
month: '03'
oa: 1
oa_version: Published Version
publication: Astronomy & Astrophysics
publication_identifier:
  eissn:
  - 1432-0746
  issn:
  - 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Deciphering stellar metallicities in the early universe: Case study of a young
  galaxy at z = 4.77 in the MUSE eXtremely Deep Field'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 660
year: '2022'
...
---
_id: '11497'
abstract:
- lang: eng
  text: "Context. The hydrogen Lyman α line is often the only measurable feature in
    optical spectra of high-redshift galaxies. Its shape and strength are influenced
    by radiative transfer processes and the properties of the underlying stellar population.
    High equivalent widths of several hundred Å are especially hard to explain by
    models and could point towards unusual stellar populations, for example with low
    metallicities, young stellar ages, and a top-heavy initial mass function. Other
    aspects influencing equivalent widths are the morphology of the galaxy and its
    gas properties.\r\nAims. The aim of this study is to better understand the connection
    between the Lyman α rest-frame equivalent width (EW0) and spectral properties
    as well as ultraviolet (UV) continuum morphology by obtaining reliable EW0 histograms
    for a statistical sample of galaxies and by assessing the fraction of objects
    with large equivalent widths.\r\nMethods. We used integral field spectroscopy
    from the Multi Unit Spectroscopic Explorer (MUSE) combined with broad-band data
    from the Hubble Space Telescope (HST) to measure EW0. We analysed the emission
    lines of 1920 Lyman α emitters (LAEs) detected in the full MUSE-Wide (one hour
    exposure time) and MUSE-Deep (ten hour exposure time) surveys and found UV continuum
    counterparts in archival HST data. We fitted the UV continuum photometric images
    using the Galfit software to gain morphological information on the rest-UV emission
    and fitted the spectra obtained from MUSE to determine the double peak fraction,
    asymmetry, full-width at half maximum, and flux of the Lyman α line.\r\nResults.
    The two surveys show different histograms of Lyman α EW0. In MUSE-Wide, 20% of
    objects have EW0 > 240 Å, while this fraction is only 11% in MUSE-Deep and ≈16%
    for the full sample. This includes objects without HST continuum counterparts
    (one-third of our sample), for which we give lower limits for EW0. The object
    with the highest securely measured EW0 has EW0 = 589 ± 193 Å (the highest lower
    limit being EW0 = 4464 Å). We investigate the connection between EW0 and Lyman
    α spectral or UV continuum morphological properties.\r\nConclusions. The survey
    depth has to be taken into account when studying EW0 distributions. We find that
    in general, high EW0 objects can have a wide range of spectral and UV morphological
    properties, which might reflect that the underlying causes for high EW0 values
    are equally varied."
acknowledgement: We thank the referee for thoughtful and constructive comments that
  have improved the quality of this manuscript. Based on observations collected at
  the European Southern Observatory under ESO programme 1101.A-0127. This work made
  use of v2.2.1 of the Binary Population and Spectral Synthesis (BPASS) models as
  described in Eldridge et al. (2017) and Stanway & Eldridge (2018). A.F. acknowledges
  the support from grant PRIN MIUR2017-20173ML3WW_001. T.N. acknowledges support from
  Australian Research Council Laureate Fellowship FL180100060.
article_number: '183'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: J.
  full_name: Kerutt, J.
  last_name: Kerutt
- first_name: L.
  full_name: Wisotzki, L.
  last_name: Wisotzki
- first_name: A.
  full_name: Verhamme, A.
  last_name: Verhamme
- first_name: K. B.
  full_name: Schmidt, K. B.
  last_name: Schmidt
- first_name: F.
  full_name: Leclercq, F.
  last_name: Leclercq
- first_name: E. C.
  full_name: Herenz, E. C.
  last_name: Herenz
- first_name: T.
  full_name: Urrutia, T.
  last_name: Urrutia
- first_name: T.
  full_name: Garel, T.
  last_name: Garel
- first_name: T.
  full_name: Hashimoto, T.
  last_name: Hashimoto
- first_name: M.
  full_name: Maseda, M.
  last_name: Maseda
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
- first_name: H.
  full_name: Kusakabe, H.
  last_name: Kusakabe
- first_name: J.
  full_name: Schaye, J.
  last_name: Schaye
- first_name: J.
  full_name: Richard, J.
  last_name: Richard
- first_name: B.
  full_name: Guiderdoni, B.
  last_name: Guiderdoni
- first_name: V.
  full_name: Mauerhofer, V.
  last_name: Mauerhofer
- first_name: T.
  full_name: Nanayakkara, T.
  last_name: Nanayakkara
- first_name: E.
  full_name: Vitte, E.
  last_name: Vitte
citation:
  ama: Kerutt J, Wisotzki L, Verhamme A, et al. Equivalent widths of Lyman α emitters
    in MUSE-Wide and MUSE-Deep. <i>Astronomy &#38; Astrophysics</i>. 2022;659. doi:<a
    href="https://doi.org/10.1051/0004-6361/202141900">10.1051/0004-6361/202141900</a>
  apa: Kerutt, J., Wisotzki, L., Verhamme, A., Schmidt, K. B., Leclercq, F., Herenz,
    E. C., … Vitte, E. (2022). Equivalent widths of Lyman α emitters in MUSE-Wide
    and MUSE-Deep. <i>Astronomy &#38; Astrophysics</i>. EDP Sciences. <a href="https://doi.org/10.1051/0004-6361/202141900">https://doi.org/10.1051/0004-6361/202141900</a>
  chicago: Kerutt, J., L. Wisotzki, A. Verhamme, K. B. Schmidt, F. Leclercq, E. C.
    Herenz, T. Urrutia, et al. “Equivalent Widths of Lyman α Emitters in MUSE-Wide
    and MUSE-Deep.” <i>Astronomy &#38; Astrophysics</i>. EDP Sciences, 2022. <a href="https://doi.org/10.1051/0004-6361/202141900">https://doi.org/10.1051/0004-6361/202141900</a>.
  ieee: J. Kerutt <i>et al.</i>, “Equivalent widths of Lyman α emitters in MUSE-Wide
    and MUSE-Deep,” <i>Astronomy &#38; Astrophysics</i>, vol. 659. EDP Sciences, 2022.
  ista: Kerutt J, Wisotzki L, Verhamme A, Schmidt KB, Leclercq F, Herenz EC, Urrutia
    T, Garel T, Hashimoto T, Maseda M, Matthee JJ, Kusakabe H, Schaye J, Richard J,
    Guiderdoni B, Mauerhofer V, Nanayakkara T, Vitte E. 2022. Equivalent widths of
    Lyman α emitters in MUSE-Wide and MUSE-Deep. Astronomy &#38; Astrophysics. 659,
    183.
  mla: Kerutt, J., et al. “Equivalent Widths of Lyman α Emitters in MUSE-Wide and
    MUSE-Deep.” <i>Astronomy &#38; Astrophysics</i>, vol. 659, 183, EDP Sciences,
    2022, doi:<a href="https://doi.org/10.1051/0004-6361/202141900">10.1051/0004-6361/202141900</a>.
  short: J. Kerutt, L. Wisotzki, A. Verhamme, K.B. Schmidt, F. Leclercq, E.C. Herenz,
    T. Urrutia, T. Garel, T. Hashimoto, M. Maseda, J.J. Matthee, H. Kusakabe, J. Schaye,
    J. Richard, B. Guiderdoni, V. Mauerhofer, T. Nanayakkara, E. Vitte, Astronomy
    &#38; Astrophysics 659 (2022).
date_created: 2022-07-06T08:17:27Z
date_published: 2022-03-25T00:00:00Z
date_updated: 2022-07-19T09:47:16Z
day: '25'
doi: 10.1051/0004-6361/202141900
extern: '1'
external_id:
  arxiv:
  - '2202.06642'
intvolume: '       659'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: high-redshift / galaxies: formation / galaxies: evolution / cosmology:
  observations'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2202.06642
month: '03'
oa: 1
oa_version: Published Version
publication: Astronomy & Astrophysics
publication_identifier:
  eissn:
  - 1432-0746
  issn:
  - 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Equivalent widths of Lyman α emitters in MUSE-Wide and MUSE-Deep
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 659
year: '2022'
...
