---
_id: '14559'
abstract:
- lang: eng
  text: We consider the problem of learning control policies in discrete-time stochastic
    systems which guarantee that the system stabilizes within some specified stabilization
    region with probability 1. Our approach is based on the novel notion of stabilizing
    ranking supermartingales (sRSMs) that we introduce in this work. Our sRSMs overcome
    the limitation of methods proposed in previous works whose applicability is restricted
    to systems in which the stabilizing region cannot be left once entered under any
    control policy. We present a learning procedure that learns a control policy together
    with an sRSM that formally certifies probability 1 stability, both learned as
    neural networks. We show that this procedure can also be adapted to formally verifying
    that, under a given Lipschitz continuous control policy, the stochastic system
    stabilizes within some stabilizing region with probability 1. Our experimental
    evaluation shows that our learning procedure can successfully learn provably stabilizing
    policies in practice.
acknowledgement: This work was supported in part by the ERC-2020-AdG 101020093, ERC
  CoG 863818 (FoRM-SMArt) and the European Union’s Horizon 2020 research and innovation
  programme under the Marie Skłodowska-Curie Grant Agreement No. 665385.
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Matin
  full_name: Ansaripour, Matin
  last_name: Ansaripour
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000-0002-2985-7724
- first_name: Mathias
  full_name: Lechner, Mathias
  id: 3DC22916-F248-11E8-B48F-1D18A9856A87
  last_name: Lechner
- first_name: Dorde
  full_name: Zikelic, Dorde
  id: 294AA7A6-F248-11E8-B48F-1D18A9856A87
  last_name: Zikelic
  orcid: 0000-0002-4681-1699
citation:
  ama: 'Ansaripour M, Chatterjee K, Henzinger TA, Lechner M, Zikelic D. Learning provably
    stabilizing neural controllers for discrete-time stochastic systems. In: <i>21st
    International Symposium on Automated Technology for Verification and Analysis</i>.
    Vol 14215. Springer Nature; 2023:357-379. doi:<a href="https://doi.org/10.1007/978-3-031-45329-8_17">10.1007/978-3-031-45329-8_17</a>'
  apa: 'Ansaripour, M., Chatterjee, K., Henzinger, T. A., Lechner, M., &#38; Zikelic,
    D. (2023). Learning provably stabilizing neural controllers for discrete-time
    stochastic systems. In <i>21st International Symposium on Automated Technology
    for Verification and Analysis</i> (Vol. 14215, pp. 357–379). Singapore, Singapore:
    Springer Nature. <a href="https://doi.org/10.1007/978-3-031-45329-8_17">https://doi.org/10.1007/978-3-031-45329-8_17</a>'
  chicago: Ansaripour, Matin, Krishnendu Chatterjee, Thomas A Henzinger, Mathias Lechner,
    and Dorde Zikelic. “Learning Provably Stabilizing Neural Controllers for Discrete-Time
    Stochastic Systems.” In <i>21st International Symposium on Automated Technology
    for Verification and Analysis</i>, 14215:357–79. Springer Nature, 2023. <a href="https://doi.org/10.1007/978-3-031-45329-8_17">https://doi.org/10.1007/978-3-031-45329-8_17</a>.
  ieee: M. Ansaripour, K. Chatterjee, T. A. Henzinger, M. Lechner, and D. Zikelic,
    “Learning provably stabilizing neural controllers for discrete-time stochastic
    systems,” in <i>21st International Symposium on Automated Technology for Verification
    and Analysis</i>, Singapore, Singapore, 2023, vol. 14215, pp. 357–379.
  ista: 'Ansaripour M, Chatterjee K, Henzinger TA, Lechner M, Zikelic D. 2023. Learning
    provably stabilizing neural controllers for discrete-time stochastic systems.
    21st International Symposium on Automated Technology for Verification and Analysis.
    ATVA: Automated Technology for Verification and Analysis, LNCS, vol. 14215, 357–379.'
  mla: Ansaripour, Matin, et al. “Learning Provably Stabilizing Neural Controllers
    for Discrete-Time Stochastic Systems.” <i>21st International Symposium on Automated
    Technology for Verification and Analysis</i>, vol. 14215, Springer Nature, 2023,
    pp. 357–79, doi:<a href="https://doi.org/10.1007/978-3-031-45329-8_17">10.1007/978-3-031-45329-8_17</a>.
  short: M. Ansaripour, K. Chatterjee, T.A. Henzinger, M. Lechner, D. Zikelic, in:,
    21st International Symposium on Automated Technology for Verification and Analysis,
    Springer Nature, 2023, pp. 357–379.
conference:
  end_date: 2023-10-27
  location: Singapore, Singapore
  name: 'ATVA: Automated Technology for Verification and Analysis'
  start_date: 2023-10-24
corr_author: '1'
date_created: 2023-11-19T23:00:56Z
date_published: 2023-10-22T00:00:00Z
date_updated: 2025-09-09T13:20:26Z
day: '22'
department:
- _id: ToHe
- _id: KrCh
doi: 10.1007/978-3-031-45329-8_17
ec_funded: 1
external_id:
  arxiv:
  - '2210.05304'
  isi:
  - '001456127300017'
fulldoi: https://doi.org/10.1007/978-3-031-45329-8_17
intvolume: '     14215'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: ' https://doi.org/10.48550/arXiv.2210.05304'
month: '10'
oa: 1
oa_version: Preprint
page: 357-379
project:
- _id: 62781420-2b32-11ec-9570-8d9b63373d4d
  call_identifier: H2020
  grant_number: '101020093'
  name: Vigilant Algorithmic Monitoring of Software
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
  call_identifier: H2020
  grant_number: '863818'
  name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication: 21st International Symposium on Automated Technology for Verification
  and Analysis
publication_identifier:
  eissn:
  - 1611-3349
  isbn:
  - '9783031453281'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Learning provably stabilizing neural controllers for discrete-time stochastic
  systems
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 14215
year: '2023'
...
---
_id: '14562'
abstract:
- lang: eng
  text: "Regulation of the Arp2/3 complex is required for productive nucleation of
    branched actin networks. An emerging aspect of regulation is the incorporation
    of subunit isoforms into the Arp2/3 complex. Specifically, both ArpC5 subunit
    isoforms, ArpC5 and ArpC5L, have been reported to fine-tune nucleation activity
    and branch junction stability. We have combined reverse genetics and cellular
    structural biology to describe how ArpC5 and ArpC5L differentially affect cell
    migration. Both define the structural stability of ArpC1 in branch junctions and,
    in turn, by determining protrusion characteristics, affect protein dynamics and
    actin network ultrastructure. ArpC5 isoforms also affect the positioning of members
    of the Ena/Vasodilator-stimulated phosphoprotein (VASP) family of actin filament
    elongators, which mediate ArpC5 isoform–specific effects on the actin assembly
    level. Our results suggest that ArpC5 and Ena/VASP proteins are part of a signaling
    pathway enhancing cell migration.\r\n"
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
- _id: ScienComp
- _id: EM-Fac
acknowledgement: "We would like to thank K. von Peinen and B. Denker (Helmholtz Centre
  for Infection Research, Braunschweig, Germany) for experimental and technical assistance,
  respectively.\r\nFunding: This research was supported by the Scientific Service
  Units (SSUs) of ISTA through resources provided by Scientific Computing (SciComp),
  the Life Science Facility (LSF), the Imaging and Optics facility (IOF), and the
  Electron Microscopy Facility (EMF). We acknowledge support from ISTA and from the
  Austrian Science Fund (FWF) (P33367) to F.K.M.S., from the Research Training Group
  GRK2223 and the Helmholtz Society to K.R,. and from the Deutsche Forschungsgemeinschaft
  (DFG) to J.F. and K.R."
article_processing_charge: No
author:
- first_name: Florian KM
  full_name: Schur, Florian KM
  id: 48AD8942-F248-11E8-B48F-1D18A9856A87
  last_name: Schur
  orcid: 0000-0003-4790-8078
citation:
  ama: Schur FK. Research data of the publication “ArpC5 isoforms regulate Arp2/3
    complex-dependent protrusion through differential Ena/VASP positioning.” 2023.
    doi:<a href="https://doi.org/10.15479/AT:ISTA:14562">10.15479/AT:ISTA:14562</a>
  apa: Schur, F. K. (2023). Research data of the publication “ArpC5 isoforms regulate
    Arp2/3 complex-dependent protrusion through differential Ena/VASP positioning.”
    Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:14562">https://doi.org/10.15479/AT:ISTA:14562</a>
  chicago: Schur, Florian KM. “Research Data of the Publication ‘ArpC5 Isoforms Regulate
    Arp2/3 Complex-Dependent Protrusion through Differential Ena/VASP Positioning.’”
    Institute of Science and Technology Austria, 2023. <a href="https://doi.org/10.15479/AT:ISTA:14562">https://doi.org/10.15479/AT:ISTA:14562</a>.
  ieee: F. K. Schur, “Research data of the publication ‘ArpC5 isoforms regulate Arp2/3
    complex-dependent protrusion through differential Ena/VASP positioning.’” Institute
    of Science and Technology Austria, 2023.
  ista: Schur FK. 2023. Research data of the publication ‘ArpC5 isoforms regulate
    Arp2/3 complex-dependent protrusion through differential Ena/VASP positioning’,
    Institute of Science and Technology Austria, <a href="https://doi.org/10.15479/AT:ISTA:14562">10.15479/AT:ISTA:14562</a>.
  mla: Schur, Florian KM. <i>Research Data of the Publication “ArpC5 Isoforms Regulate
    Arp2/3 Complex-Dependent Protrusion through Differential Ena/VASP Positioning.”</i>
    Institute of Science and Technology Austria, 2023, doi:<a href="https://doi.org/10.15479/AT:ISTA:14562">10.15479/AT:ISTA:14562</a>.
  short: F.K. Schur, (2023).
contributor:
- contributor_type: researcher
  first_name: Florian
  id: 404F5528-F248-11E8-B48F-1D18A9856A87
  last_name: Fäßler
  orcid: 0000-0001-7149-769X
- contributor_type: researcher
  first_name: Manjunath
  id: 305ab18b-dc7d-11ea-9b2f-b58195228ea2
  last_name: Javoor
- contributor_type: researcher
  first_name: Julia
  id: 3B12E2E6-F248-11E8-B48F-1D18A9856A87
  last_name: Datler
  orcid: 0000-0002-3616-8580
- contributor_type: researcher
  first_name: Hermann
  last_name: Döring
- contributor_type: researcher
  first_name: Florian
  id: b9d234ba-9e33-11ed-95b6-cd561df280e6
  last_name: Hofer
- contributor_type: researcher
  first_name: Georgi A
  id: 38C393BE-F248-11E8-B48F-1D18A9856A87
  last_name: Dimchev
  orcid: 0000-0001-8370-6161
- contributor_type: researcher
  first_name: Victor-Valentin
  id: 3661B498-F248-11E8-B48F-1D18A9856A87
  last_name: Hodirnau
- contributor_type: researcher
  first_name: Jan
  last_name: Faix
- contributor_type: researcher
  first_name: Klemens
  last_name: Rottner
- contributor_type: researcher
  first_name: Florian KM
  id: 48AD8942-F248-11E8-B48F-1D18A9856A87
  last_name: Schur
  orcid: 0000-0003-4790-8078
corr_author: '1'
date_created: 2023-11-20T09:22:33Z
date_published: 2023-11-21T00:00:00Z
date_updated: 2025-04-23T08:46:21Z
day: '21'
ddc:
- '570'
department:
- _id: FlSc
doi: 10.15479/AT:ISTA:14562
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fulldoi: https://doi.org/10.15479/AT:ISTA:14562
has_accepted_license: '1'
license: https://creativecommons.org/licenses/by-sa/4.0/
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 9B954C5C-BA93-11EA-9121-9846C619BF3A
  grant_number: P33367
  name: Structure and isoform diversity of the Arp2/3 complex
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '12334'
    relation: used_in_publication
    status: public
status: public
title: Research data of the publication "ArpC5 isoforms regulate Arp2/3 complex-dependent
  protrusion through differential Ena/VASP positioning"
tmp:
  image: /images/cc_by_sa.png
  legal_code_url: https://creativecommons.org/licenses/by-sa/4.0/legalcode
  name: Creative Commons Attribution-ShareAlike 4.0 International Public License (CC
    BY-SA 4.0)
  short: CC BY-SA (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '14564'
abstract:
- lang: eng
  text: Cumulus parameterization (CP) in state‐of‐the‐art global climate models is
    based on the quasi‐equilibrium assumption (QEA), which views convection as the
    action of an ensemble of cumulus clouds, in a state of equilibrium with respect
    to a slowly varying atmospheric state. This view is not compatible with the organization
    and dynamical interactions across multiple scales of cloud systems in the tropics
    and progress in this research area was slow over decades despite the widely recognized
    major shortcomings. Novel ideas on how to represent key physical processes of
    moist convection‐large‐scale interaction to overcome the QEA have surged recently.
    The stochastic multicloud model (SMCM) CP in particular mimics the dynamical interactions
    of multiple cloud types that characterize organized tropical convection. Here,
    the SMCM is used to modify the Zhang‐McFarlane (ZM) CP by changing the way in
    which the bulk mass flux and bulk entrainment and detrainment rates are calculated.
    This is done by introducing a stochastic ensemble of plumes characterized by randomly
    varying detrainment level distributions based on the cloud area fraction of the
    SMCM. The SMCM is here extended to include shallow cumulus clouds resulting in
    a unified shallow‐deep CP. The new stochastic multicloud plume CP is validated
    against the control ZM scheme in the context of the single column Community Climate
    Model of the National Center for Atmospheric Research using data from both tropical
    ocean and midlatitude land convection. Some key features of the SMCM CP such as
    it capability to represent the tri‐modal nature of organized convection are emphasized.
acknowledgement: The research of B.K. is supported in part by a Discovery Grant from
  the Natural Sciences and Engineering Research Council of Canada (RGPIN-04246-2020).
  This research was conducted during the visits of P.M. Krishna to the Center for
  Prototype Climate Models at NYU Abu Dhabi and University of Victoria from November
  2018 to June 2019 and July 2019 and October 2019, respectively. The authors are
  very grateful to the three anonymous reviewers who provided very thoughtful and
  constructive comments during the review process that helped greatly improve and
  shape the final version of the manuscript.
article_number: e2022MS003391
article_processing_charge: Yes
article_type: original
author:
- first_name: B.
  full_name: Khouider, B.
  last_name: Khouider
- first_name: BIDYUT B
  full_name: GOSWAMI, BIDYUT B
  id: 3a4ac09c-6d61-11ec-bf66-884cde66b64b
  last_name: GOSWAMI
  orcid: 0000-0001-8602-3083
- first_name: R.
  full_name: Phani, R.
  last_name: Phani
- first_name: A. J.
  full_name: Majda, A. J.
  last_name: Majda
citation:
  ama: Khouider B, GOSWAMI BB, Phani R, Majda AJ. A shallow‐deep unified stochastic
    mass flux cumulus parameterization in the single column community climate model.
    <i>Journal of Advances in Modeling Earth Systems</i>. 2023;15(11). doi:<a href="https://doi.org/10.1029/2022ms003391">10.1029/2022ms003391</a>
  apa: Khouider, B., GOSWAMI, B. B., Phani, R., &#38; Majda, A. J. (2023). A shallow‐deep
    unified stochastic mass flux cumulus parameterization in the single column community
    climate model. <i>Journal of Advances in Modeling Earth Systems</i>. American
    Geophysical Union. <a href="https://doi.org/10.1029/2022ms003391">https://doi.org/10.1029/2022ms003391</a>
  chicago: Khouider, B., BIDYUT B GOSWAMI, R. Phani, and A. J. Majda. “A Shallow‐deep
    Unified Stochastic Mass Flux Cumulus Parameterization in the Single Column Community
    Climate Model.” <i>Journal of Advances in Modeling Earth Systems</i>. American
    Geophysical Union, 2023. <a href="https://doi.org/10.1029/2022ms003391">https://doi.org/10.1029/2022ms003391</a>.
  ieee: B. Khouider, B. B. GOSWAMI, R. Phani, and A. J. Majda, “A shallow‐deep unified
    stochastic mass flux cumulus parameterization in the single column community climate
    model,” <i>Journal of Advances in Modeling Earth Systems</i>, vol. 15, no. 11.
    American Geophysical Union, 2023.
  ista: Khouider B, GOSWAMI BB, Phani R, Majda AJ. 2023. A shallow‐deep unified stochastic
    mass flux cumulus parameterization in the single column community climate model.
    Journal of Advances in Modeling Earth Systems. 15(11), e2022MS003391.
  mla: Khouider, B., et al. “A Shallow‐deep Unified Stochastic Mass Flux Cumulus Parameterization
    in the Single Column Community Climate Model.” <i>Journal of Advances in Modeling
    Earth Systems</i>, vol. 15, no. 11, e2022MS003391, American Geophysical Union,
    2023, doi:<a href="https://doi.org/10.1029/2022ms003391">10.1029/2022ms003391</a>.
  short: B. Khouider, B.B. GOSWAMI, R. Phani, A.J. Majda, Journal of Advances in Modeling
    Earth Systems 15 (2023).
date_created: 2023-11-20T09:18:21Z
date_published: 2023-11-01T00:00:00Z
date_updated: 2025-09-09T13:29:45Z
day: '01'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1029/2022ms003391
external_id:
  isi:
  - '001106311000001'
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  success: 1
file_date_updated: 2023-11-20T11:29:16Z
fulldoi: https://doi.org/10.1029/2022ms003391
has_accepted_license: '1'
intvolume: '        15'
isi: 1
issue: '11'
keyword:
- General Earth and Planetary Sciences
- Environmental Chemistry
- Global and Planetary Change
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '11'
oa: 1
oa_version: Published Version
publication: Journal of Advances in Modeling Earth Systems
publication_identifier:
  eissn:
  - 1942-2466
publication_status: published
publisher: American Geophysical Union
quality_controlled: '1'
scopus_import: '1'
status: public
title: A shallow‐deep unified stochastic mass flux cumulus parameterization in the
  single column community climate model
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 15
year: '2023'
...
---
_id: '14579'
abstract:
- lang: eng
  text: "This is associated with our paper \"Plant size, latitude, and phylogeny explain
    within-population variability in herbivory\" published in Science.\r\n"
article_processing_charge: No
author:
- first_name: William
  full_name: Wetzel, William
  last_name: Wetzel
citation:
  ama: 'Wetzel W. HerbVar-Network/HV-Large-Patterns-MS-public: v1.0.0. 2023. doi:<a
    href="https://doi.org/10.5281/ZENODO.8133117">10.5281/ZENODO.8133117</a>'
  apa: 'Wetzel, W. (2023). HerbVar-Network/HV-Large-Patterns-MS-public: v1.0.0. Zenodo.
    <a href="https://doi.org/10.5281/ZENODO.8133117">https://doi.org/10.5281/ZENODO.8133117</a>'
  chicago: 'Wetzel, William. “HerbVar-Network/HV-Large-Patterns-MS-Public: V1.0.0.”
    Zenodo, 2023. <a href="https://doi.org/10.5281/ZENODO.8133117">https://doi.org/10.5281/ZENODO.8133117</a>.'
  ieee: 'W. Wetzel, “HerbVar-Network/HV-Large-Patterns-MS-public: v1.0.0.” Zenodo,
    2023.'
  ista: 'Wetzel W. 2023. HerbVar-Network/HV-Large-Patterns-MS-public: v1.0.0, Zenodo,
    <a href="https://doi.org/10.5281/ZENODO.8133117">10.5281/ZENODO.8133117</a>.'
  mla: 'Wetzel, William. <i>HerbVar-Network/HV-Large-Patterns-MS-Public: V1.0.0</i>.
    Zenodo, 2023, doi:<a href="https://doi.org/10.5281/ZENODO.8133117">10.5281/ZENODO.8133117</a>.'
  short: W. Wetzel, (2023).
date_created: 2023-11-20T11:07:45Z
date_published: 2023-07-11T00:00:00Z
date_updated: 2025-09-09T13:23:55Z
day: '11'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.5281/ZENODO.8133117
fulldoi: https://doi.org/10.5281/ZENODO.8133117
main_file_link:
- open_access: '1'
  url: https://doi.org/10.5281/zenodo.8133118
month: '07'
oa: 1
oa_version: Published Version
publisher: Zenodo
related_material:
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  - id: '14552'
    relation: used_in_publication
    status: public
status: public
title: 'HerbVar-Network/HV-Large-Patterns-MS-public: v1.0.0'
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
OA_place: publisher
_id: '14587'
abstract:
- lang: eng
  text: "This thesis concerns the application of variational methods to the study
    of evolution problems arising in fluid mechanics and in material sciences. The
    main focus is on weak-strong stability properties of some curvature driven interface
    evolution problems, such as the two-phase Navier–Stokes flow with surface tension
    and multiphase mean curvature flow, and on the phase-field approximation of the
    latter. Furthermore, we discuss a variational approach to the study of a class
    of doubly nonlinear wave equations.\r\nFirst, we consider the two-phase Navier–Stokes
    flow with surface tension within a bounded domain. The two fluids are immiscible
    and separated by a sharp interface, which intersects the boundary of the domain
    at a constant contact angle of ninety degree. We devise a suitable concept of
    varifolds solutions for the associated interface evolution problem and we establish
    a weak-strong uniqueness principle in case of a two dimensional ambient space.
    In order to focus on the boundary effects and on the singular geometry of the
    evolving domains, we work for simplicity in the regime of same viscosities for
    the two fluids.\r\nThe core of the thesis consists in the rigorous proof of the
    convergence of the vectorial Allen-Cahn equation towards multiphase mean curvature
    flow for a suitable class of multi- well potentials and for well-prepared initial
    data. We even establish a rate of convergence. Our relative energy approach relies
    on the concept of gradient-flow calibration for branching singularities in multiphase
    mean curvature flow and thus enables us to overcome the limitations of other approaches.
    To the best of the author’s knowledge, our result is the first quantitative and
    unconditional one available in the literature for the vectorial/multiphase setting.\r\nThis
    thesis also contains a first study of weak-strong stability for planar multiphase
    mean curvature flow beyond the singularity resulting from a topology change. Previous
    weak-strong results are indeed limited to time horizons before the first topology
    change of the strong solution. We consider circular topology changes and we prove
    weak-strong stability for BV solutions to planar multiphase mean curvature flow
    beyond the associated singular times by dynamically adapting the strong solutions
    to the weak one by means of a space-time shift.\r\nIn the context of interface
    evolution problems, our proofs for the main results of this thesis are based on
    the relative energy technique, relying on novel suitable notions of relative energy
    functionals, which in particular measure the interface error. Our statements follow
    from the resulting stability estimates for the relative energy associated to the
    problem.\r\nAt last, we introduce a variational approach to the study of nonlinear
    evolution problems. This approach hinges on the minimization of a parameter dependent
    family of convex functionals over entire trajectories, known as Weighted Inertia-Dissipation-Energy
    (WIDE) functionals. We consider a class of doubly nonlinear wave equations and
    establish the convergence, up to subsequences, of the associated WIDE minimizers
    to a solution of the target problem as the parameter goes to zero."
acknowledgement: The research projects contained in this thesis have received funding
  from the European Research Council (ERC) under the European Union’s Horizon 2020
  research and innovation programme (grant agreement No 948819).
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Alice
  full_name: Marveggio, Alice
  id: 25647992-AA84-11E9-9D75-8427E6697425
  last_name: Marveggio
citation:
  ama: Marveggio A. Weak-strong stability and phase-field approximation of interface
    evolution problems in fluid mechanics and in material sciences. 2023. doi:<a href="https://doi.org/10.15479/at:ista:14587">10.15479/at:ista:14587</a>
  apa: Marveggio, A. (2023). <i>Weak-strong stability and phase-field approximation
    of interface evolution problems in fluid mechanics and in material sciences</i>.
    Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/at:ista:14587">https://doi.org/10.15479/at:ista:14587</a>
  chicago: Marveggio, Alice. “Weak-Strong Stability and Phase-Field Approximation
    of Interface Evolution Problems in Fluid Mechanics and in Material Sciences.”
    Institute of Science and Technology Austria, 2023. <a href="https://doi.org/10.15479/at:ista:14587">https://doi.org/10.15479/at:ista:14587</a>.
  ieee: A. Marveggio, “Weak-strong stability and phase-field approximation of interface
    evolution problems in fluid mechanics and in material sciences,” Institute of
    Science and Technology Austria, 2023.
  ista: Marveggio A. 2023. Weak-strong stability and phase-field approximation of
    interface evolution problems in fluid mechanics and in material sciences. Institute
    of Science and Technology Austria.
  mla: Marveggio, Alice. <i>Weak-Strong Stability and Phase-Field Approximation of
    Interface Evolution Problems in Fluid Mechanics and in Material Sciences</i>.
    Institute of Science and Technology Austria, 2023, doi:<a href="https://doi.org/10.15479/at:ista:14587">10.15479/at:ista:14587</a>.
  short: A. Marveggio, Weak-Strong Stability and Phase-Field Approximation of Interface
    Evolution Problems in Fluid Mechanics and in Material Sciences, Institute of Science
    and Technology Austria, 2023.
corr_author: '1'
date_created: 2023-11-21T11:41:05Z
date_published: 2023-11-21T00:00:00Z
date_updated: 2026-04-07T13:28:13Z
day: '21'
ddc:
- '515'
degree_awarded: PhD
department:
- _id: GradSch
- _id: JuFi
doi: 10.15479/at:ista:14587
ec_funded: 1
file:
- access_level: open_access
  checksum: 6c7db4cc86da6cdc79f7f358dc7755d4
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  file_size: 2881100
  relation: main_file
  success: 1
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  file_id: '14627'
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file_date_updated: 2024-03-20T12:28:32Z
fulldoi: https://doi.org/10.15479/at:ista:14587
has_accepted_license: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '11'
oa: 1
oa_version: Published Version
page: '228'
project:
- _id: 0aa76401-070f-11eb-9043-b5bb049fa26d
  call_identifier: H2020
  grant_number: '948819'
  name: Bridging Scales in Random Materials
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '11842'
    relation: part_of_dissertation
    status: public
  - id: '14597'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Julian L
  full_name: Fischer, Julian L
  id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
  last_name: Fischer
  orcid: 0000-0002-0479-558X
title: Weak-strong stability and phase-field approximation of interface evolution
  problems in fluid mechanics and in material sciences
tmp:
  image: /images/cc_by_nc_sa.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
    BY-NC-SA 4.0)
  short: CC BY-NC-SA (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2023'
...
---
_id: '14604'
abstract:
- lang: eng
  text: Sex chromosomes have evolved independently multiple times, but why some are
    conserved for more than 100 million years whereas others turnover rapidly remains
    an open question. Here, we examine the homology of sex chromosomes across nine
    orders of insects, plus the outgroup springtails. We find that the X chromosome
    is likely homologous across insects and springtails; the only exception is in
    the Lepidoptera, which has lost the X and now has a ZZ/ZW sex-chromosome system.
    These results suggest the ancestral insect X chromosome has persisted for more
    than 450 million years—the oldest known sex chromosome to date. Further, we propose
    that the shrinking of gene content the dipteran X chromosome has allowed for a
    burst of sex-chromosome turnover that is absent from other speciose insect orders.
acknowledgement: All computational analyses were performed on the server at Institute
  of Science and Technology Austria. We thank Marwan Elkrewi and Vincent Bett for
  analytical advice, and Tanja Schwander and Vincent Merel for useful discussions.
  We also thank Matthew Hahn for comments on an earlier version of the manuscript.
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Melissa A
  full_name: Toups, Melissa A
  id: 4E099E4E-F248-11E8-B48F-1D18A9856A87
  last_name: Toups
  orcid: 0000-0002-9752-7380
- first_name: Beatriz
  full_name: Vicoso, Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
citation:
  ama: Toups MA, Vicoso B. The X chromosome of insects likely predates the origin
    of class Insecta. <i>Evolution</i>. 2023;77(11):2504-2511. doi:<a href="https://doi.org/10.1093/evolut/qpad169">10.1093/evolut/qpad169</a>
  apa: Toups, M. A., &#38; Vicoso, B. (2023). The X chromosome of insects likely predates
    the origin of class Insecta. <i>Evolution</i>. Oxford University Press. <a href="https://doi.org/10.1093/evolut/qpad169">https://doi.org/10.1093/evolut/qpad169</a>
  chicago: Toups, Melissa A, and Beatriz Vicoso. “The X Chromosome of Insects Likely
    Predates the Origin of Class Insecta.” <i>Evolution</i>. Oxford University Press,
    2023. <a href="https://doi.org/10.1093/evolut/qpad169">https://doi.org/10.1093/evolut/qpad169</a>.
  ieee: M. A. Toups and B. Vicoso, “The X chromosome of insects likely predates the
    origin of class Insecta,” <i>Evolution</i>, vol. 77, no. 11. Oxford University
    Press, pp. 2504–2511, 2023.
  ista: Toups MA, Vicoso B. 2023. The X chromosome of insects likely predates the
    origin of class Insecta. Evolution. 77(11), 2504–2511.
  mla: Toups, Melissa A., and Beatriz Vicoso. “The X Chromosome of Insects Likely
    Predates the Origin of Class Insecta.” <i>Evolution</i>, vol. 77, no. 11, Oxford
    University Press, 2023, pp. 2504–11, doi:<a href="https://doi.org/10.1093/evolut/qpad169">10.1093/evolut/qpad169</a>.
  short: M.A. Toups, B. Vicoso, Evolution 77 (2023) 2504–2511.
date_created: 2023-11-26T23:00:54Z
date_published: 2023-11-02T00:00:00Z
date_updated: 2025-09-09T13:32:06Z
day: '02'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1093/evolut/qpad169
external_id:
  isi:
  - '001170341900014'
  pmid:
  - '37738212'
file:
- access_level: open_access
  checksum: b66dc10edae92d38918d534e64dda77c
  content_type: application/pdf
  creator: dernst
  date_created: 2023-11-28T08:12:15Z
  date_updated: 2023-11-28T08:12:15Z
  file_id: '14618'
  file_name: 2023_Evolution_Toups.pdf
  file_size: 1399102
  relation: main_file
  success: 1
file_date_updated: 2023-11-28T08:12:15Z
fulldoi: https://doi.org/10.1093/evolut/qpad169
has_accepted_license: '1'
intvolume: '        77'
isi: 1
issue: '11'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '11'
oa: 1
oa_version: Published Version
page: 2504-2511
pmid: 1
publication: Evolution
publication_identifier:
  eissn:
  - 1558-5646
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
related_material:
  link:
  - relation: software
    url: https://git.ista.ac.at/bvicoso/veryoldx
  record:
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    relation: research_data
    status: public
  - id: '14617'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: The X chromosome of insects likely predates the origin of class Insecta
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 77
year: '2023'
...
---
_id: '14610'
abstract:
- lang: eng
  text: Endomembrane damage represents a form of stress that is detrimental for eukaryotic
    cells<jats:sup>1,2</jats:sup>. To cope with this threat, cells possess mechanisms
    that repair the damage and restore cellular homeostasis<jats:sup>3–7</jats:sup>.
    Endomembrane damage also results in organelle instability and the mechanisms by
    which cells stabilize damaged endomembranes to enable membrane repair remains
    unknown. Here, by combining in vitro and in cellulo studies with computational
    modelling we uncover a biological function for stress granules whereby these biomolecular
    condensates form rapidly at endomembrane damage sites and act as a plug that stabilizes
    the ruptured membrane. Functionally, we demonstrate that stress granule formation
    and membrane stabilization enable efficient repair of damaged endolysosomes, through
    both ESCRT (endosomal sorting complex required for transport)-dependent and independent
    mechanisms. We also show that blocking stress granule formation in human macrophages
    creates a permissive environment for <jats:italic>Mycobacterium tuberculosis</jats:italic>,
    a human pathogen that exploits endomembrane damage to survive within the host.
acknowledgement: "We thank the Human Embryonic Stem Cell Unit, Advanced Light Microscopy
  and High-throughput Screening facilities at the Crick for their support in various
  aspects of the work. We thank the laboratory of P. Anderson for providing the G3BP-DKO
  U2OS cells. The authors thank N. Chen for providing the purified glycinin protein;
  Z. Zhao for providing the microfluidic chip wafers; and M. Amaral and F. Frey for
  helpful discussions and valuable input regarding analysis methods. This work was
  supported by the Francis Crick Institute (to M.G.G.), which receives its core funding
  from Cancer Research UK (FC001092), the UK Medical Research Council (FC001092) and
  the Wellcome Trust (FC001092). This project has received funding from the European
  Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
  programme (grant agreement no. 772022 to M.G.G.). C.B. has received funding from
  the European Respiratory Society and the European Union’s H2020 research and innovation
  programme under the Marie Sklodowska-Curie grant agreement no. 713406. A.M. acknowledges
  support from Alexander von Humboldt Foundation and C.V.-C. acknowledges funding
  by the Royal Society and the European Research Council under the European Union’s
  Horizon 2020 Research and Innovation Programme (grant no. 802960 to A.S.). All simulations
  were carried out on the high-performance computing cluster at the Institute of Science
  and Technology Austria. For the purpose of Open Access, the author has applied a
  CC BY public copyright licence to any Author Accepted Manuscript version arising
  from this submission.\r\nOpen Access funding provided by The Francis Crick Institute."
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Claudio
  full_name: Bussi, Claudio
  last_name: Bussi
- first_name: Agustín
  full_name: Mangiarotti, Agustín
  last_name: Mangiarotti
- first_name: Christian Eduardo
  full_name: Vanhille-Campos, Christian Eduardo
  id: 3adeca52-9313-11ed-b1ac-c170b2505714
  last_name: Vanhille-Campos
- first_name: Beren
  full_name: Aylan, Beren
  last_name: Aylan
- first_name: Enrica
  full_name: Pellegrino, Enrica
  last_name: Pellegrino
- first_name: Natalia
  full_name: Athanasiadi, Natalia
  last_name: Athanasiadi
- first_name: Antony
  full_name: Fearns, Antony
  last_name: Fearns
- first_name: Angela
  full_name: Rodgers, Angela
  last_name: Rodgers
- first_name: Titus M.
  full_name: Franzmann, Titus M.
  last_name: Franzmann
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
- first_name: Rumiana
  full_name: Dimova, Rumiana
  last_name: Dimova
- first_name: Maximiliano G.
  full_name: Gutierrez, Maximiliano G.
  last_name: Gutierrez
citation:
  ama: Bussi C, Mangiarotti A, Vanhille-Campos CE, et al. Stress granules plug and
    stabilize damaged endolysosomal membranes. <i>Nature</i>. 2023;623:1062-1069.
    doi:<a href="https://doi.org/10.1038/s41586-023-06726-w">10.1038/s41586-023-06726-w</a>
  apa: Bussi, C., Mangiarotti, A., Vanhille-Campos, C. E., Aylan, B., Pellegrino,
    E., Athanasiadi, N., … Gutierrez, M. G. (2023). Stress granules plug and stabilize
    damaged endolysosomal membranes. <i>Nature</i>. Springer Nature. <a href="https://doi.org/10.1038/s41586-023-06726-w">https://doi.org/10.1038/s41586-023-06726-w</a>
  chicago: Bussi, Claudio, Agustín Mangiarotti, Christian Eduardo Vanhille-Campos,
    Beren Aylan, Enrica Pellegrino, Natalia Athanasiadi, Antony Fearns, et al. “Stress
    Granules Plug and Stabilize Damaged Endolysosomal Membranes.” <i>Nature</i>. Springer
    Nature, 2023. <a href="https://doi.org/10.1038/s41586-023-06726-w">https://doi.org/10.1038/s41586-023-06726-w</a>.
  ieee: C. Bussi <i>et al.</i>, “Stress granules plug and stabilize damaged endolysosomal
    membranes,” <i>Nature</i>, vol. 623. Springer Nature, pp. 1062–1069, 2023.
  ista: Bussi C, Mangiarotti A, Vanhille-Campos CE, Aylan B, Pellegrino E, Athanasiadi
    N, Fearns A, Rodgers A, Franzmann TM, Šarić A, Dimova R, Gutierrez MG. 2023. Stress
    granules plug and stabilize damaged endolysosomal membranes. Nature. 623, 1062–1069.
  mla: Bussi, Claudio, et al. “Stress Granules Plug and Stabilize Damaged Endolysosomal
    Membranes.” <i>Nature</i>, vol. 623, Springer Nature, 2023, pp. 1062–69, doi:<a
    href="https://doi.org/10.1038/s41586-023-06726-w">10.1038/s41586-023-06726-w</a>.
  short: C. Bussi, A. Mangiarotti, C.E. Vanhille-Campos, B. Aylan, E. Pellegrino,
    N. Athanasiadi, A. Fearns, A. Rodgers, T.M. Franzmann, A. Šarić, R. Dimova, M.G.
    Gutierrez, Nature 623 (2023) 1062–1069.
date_created: 2023-11-27T07:56:37Z
date_published: 2023-11-30T00:00:00Z
date_updated: 2025-09-09T13:30:34Z
day: '30'
ddc:
- '570'
department:
- _id: AnSa
doi: 10.1038/s41586-023-06726-w
external_id:
  isi:
  - '001105882300018'
  pmid:
  - '37968398'
file:
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  date_updated: 2024-07-16T07:41:39Z
  file_id: '17248'
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file_date_updated: 2024-07-16T07:41:39Z
fulldoi: https://doi.org/10.1038/s41586-023-06726-w
has_accepted_license: '1'
intvolume: '       623'
isi: 1
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 1062-1069
pmid: 1
publication: Nature
publication_identifier:
  eissn:
  - 1476-4687
  issn:
  - 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - relation: erratum
    url: https://doi.org/10.1038/s41586-023-06882-z
  record:
  - id: '14472'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Stress granules plug and stabilize damaged endolysosomal membranes
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 623
year: '2023'
...
---
_id: '14614'
abstract:
- lang: eng
  text: 'Many insects carry an ancient X chromosome—the Drosophila Muller element
    F—that likely predates their origin. Interestingly, the X has undergone turnover
    in multiple fly species (Diptera) after being conserved for more than 450 My.
    The long evolutionary distance between Diptera and other sequenced insect clades
    makes it difficult to infer what could have contributed to this sudden increase
    in rate of turnover. Here, we produce the first genome and transcriptome of scorpionflies
    (genus Panorpa), an insect belonging to a long overlooked sister-order to Diptera:
    Mecoptera. Combining our genome assembly with genomic short-read data, we obtain
    genome coverage and identify X-linked super-scaffolds. We further perform a gene
    homology analysis between the Panorpa X and a closely related Diptera species,
    and we assess the conservation of the Panorpa X-linked gene content with that
    of more distantly related insect species. We explored the structure of the Panorpa
    X by determining its repeat content, GC content, and nucleotide diversity. Finally,
    we used RNAseq data to detect the presence of dosage compensation in somatic tissues,
    as well as to explore gene expression tissue-specificity, and sex-bias in gene
    expression. We find high conservation of gene content between the mecopteran X
    and the dipteran Muller F element, as well as several shared biological features,
    such as the presence of dosage compensation and a low amount of genetic diversity,
    consistent with a low recombination rate. However, the 2 homologous X chromosomes
    differ strikingly in their size and number of genes they carry. Our results therefore
    support a common ancestry of the mecopteran and ancestral dipteran X chromosomes,
    and suggest that Muller element F shrank in size and gene content after the split
    of Diptera and Mecoptera, which may have contributed to its turnover in dipteran
    insects.'
article_processing_charge: No
author:
- first_name: Clementine
  full_name: Lasne, Clementine
  id: 02225f57-50d2-11eb-9ed8-8c92b9a34237
  last_name: Lasne
  orcid: 0000-0002-1197-8616
- first_name: Marwan N
  full_name: Elkrewi, Marwan N
  id: 0B46FACA-A8E1-11E9-9BD3-79D1E5697425
  last_name: Elkrewi
  orcid: 0000-0002-5328-7231
citation:
  ama: Lasne C, Elkrewi MN. The scorpionfly (Panorpa cognata) genome highlights conserved
    and derived features of the peculiar dipteran X chromosome. 2023. doi:<a href="https://doi.org/10.15479/AT:ISTA:14614">10.15479/AT:ISTA:14614</a>
  apa: Lasne, C., &#38; Elkrewi, M. N. (2023). The scorpionfly (Panorpa cognata) genome
    highlights conserved and derived features of the peculiar dipteran X chromosome.
    Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:14614">https://doi.org/10.15479/AT:ISTA:14614</a>
  chicago: Lasne, Clementine, and Marwan N Elkrewi. “The Scorpionfly (Panorpa Cognata)
    Genome Highlights Conserved and Derived Features of the Peculiar Dipteran X Chromosome.”
    Institute of Science and Technology Austria, 2023. <a href="https://doi.org/10.15479/AT:ISTA:14614">https://doi.org/10.15479/AT:ISTA:14614</a>.
  ieee: C. Lasne and M. N. Elkrewi, “The scorpionfly (Panorpa cognata) genome highlights
    conserved and derived features of the peculiar dipteran X chromosome.” Institute
    of Science and Technology Austria, 2023.
  ista: Lasne C, Elkrewi MN. 2023. The scorpionfly (Panorpa cognata) genome highlights
    conserved and derived features of the peculiar dipteran X chromosome, Institute
    of Science and Technology Austria, <a href="https://doi.org/10.15479/AT:ISTA:14614">10.15479/AT:ISTA:14614</a>.
  mla: Lasne, Clementine, and Marwan N. Elkrewi. <i>The Scorpionfly (Panorpa Cognata)
    Genome Highlights Conserved and Derived Features of the Peculiar Dipteran X Chromosome</i>.
    Institute of Science and Technology Austria, 2023, doi:<a href="https://doi.org/10.15479/AT:ISTA:14614">10.15479/AT:ISTA:14614</a>.
  short: C. Lasne, M.N. Elkrewi, (2023).
contributor:
- contributor_type: researcher
  first_name: Marwan N
  id: 0B46FACA-A8E1-11E9-9BD3-79D1E5697425
  last_name: Elkrewi
  orcid: 0000-0002-5328-7231
corr_author: '1'
date_created: 2023-11-27T16:39:19Z
date_published: 2023-12-01T00:00:00Z
date_updated: 2025-09-09T13:33:22Z
day: '01'
ddc:
- '576'
department:
- _id: BeVi
doi: 10.15479/AT:ISTA:14614
file:
- access_level: open_access
  checksum: cd0f13322b5156819ecaebd2bc8e7d12
  content_type: application/zip
  creator: clasne
  date_created: 2023-11-28T13:15:26Z
  date_updated: 2023-11-28T13:15:26Z
  file_id: '14625'
  file_name: panorpaX.zip
  file_size: 404968272
  relation: main_file
  success: 1
- access_level: open_access
  checksum: 9ff600416577687a737cb3c96dfcb26c
  content_type: text/plain
  creator: clasne
  date_created: 2023-11-30T14:16:59Z
  date_updated: 2023-11-30T14:16:59Z
  file_id: '14634'
  file_name: panorpa_readme.txt
  file_size: 2625
  relation: main_file
  success: 1
file_date_updated: 2023-11-30T14:16:59Z
fulldoi: https://doi.org/10.15479/AT:ISTA:14614
has_accepted_license: '1'
keyword:
- Panorpa
- scorpionfly
- genome
- transcriptome
month: '12'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '14613'
    relation: used_in_publication
    status: public
status: public
title: The scorpionfly (Panorpa cognata) genome highlights conserved and derived features
  of the peculiar dipteran X chromosome
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '14616'
abstract:
- lang: eng
  text: Sex chromosomes have evolved independently multiple times, but why some are
    conserved for more than 100 million years whereas others turnover rapidly remains
    an open question. Here, we examine the homology of sex chromosomes across nine
    orders of insects, plus the outgroup springtails. We find that the X chromosome
    is likely homologous across insects and springtails; the only exception is in
    the Lepidoptera, which has lost the X and now has a ZZ/ZW sex chromosome system.
    These results suggest the ancestral insect X chromosome has persisted for more
    than 450 million years – the oldest known sex chromosome to date. Further, we
    propose that the shrinking of gene content of the Dipteran X chromosome has allowed
    for a burst of sex-chromosome turnover that is absent from other speciose insect
    orders.
article_processing_charge: No
author:
- first_name: Melissa A
  full_name: Toups, Melissa A
  id: 4E099E4E-F248-11E8-B48F-1D18A9856A87
  last_name: Toups
  orcid: 0000-0002-9752-7380
- first_name: Beatriz
  full_name: Vicoso, Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
citation:
  ama: Toups MA, Vicoso B. The X chromosome of insects likely predates the origin
    of Class Insecta. 2023. doi:<a href="https://doi.org/10.5061/DRYAD.HX3FFBGKT">10.5061/DRYAD.HX3FFBGKT</a>
  apa: Toups, M. A., &#38; Vicoso, B. (2023). The X chromosome of insects likely predates
    the origin of Class Insecta. Dryad. <a href="https://doi.org/10.5061/DRYAD.HX3FFBGKT">https://doi.org/10.5061/DRYAD.HX3FFBGKT</a>
  chicago: Toups, Melissa A, and Beatriz Vicoso. “The X Chromosome of Insects Likely
    Predates the Origin of Class Insecta.” Dryad, 2023. <a href="https://doi.org/10.5061/DRYAD.HX3FFBGKT">https://doi.org/10.5061/DRYAD.HX3FFBGKT</a>.
  ieee: M. A. Toups and B. Vicoso, “The X chromosome of insects likely predates the
    origin of Class Insecta.” Dryad, 2023.
  ista: Toups MA, Vicoso B. 2023. The X chromosome of insects likely predates the
    origin of Class Insecta, Dryad, <a href="https://doi.org/10.5061/DRYAD.HX3FFBGKT">10.5061/DRYAD.HX3FFBGKT</a>.
  mla: Toups, Melissa A., and Beatriz Vicoso. <i>The X Chromosome of Insects Likely
    Predates the Origin of Class Insecta</i>. Dryad, 2023, doi:<a href="https://doi.org/10.5061/DRYAD.HX3FFBGKT">10.5061/DRYAD.HX3FFBGKT</a>.
  short: M.A. Toups, B. Vicoso, (2023).
date_created: 2023-11-28T08:01:53Z
date_published: 2023-09-15T00:00:00Z
date_updated: 2025-09-09T13:32:05Z
day: '15'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.5061/DRYAD.HX3FFBGKT
fulldoi: https://doi.org/10.5061/DRYAD.HX3FFBGKT
has_accepted_license: '1'
license: https://creativecommons.org/publicdomain/zero/1.0/
main_file_link:
- open_access: '1'
  url: https://doi.org/10.5061/dryad.hx3ffbgkt
month: '09'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
  record:
  - id: '14604'
    relation: used_in_publication
    status: public
status: public
title: The X chromosome of insects likely predates the origin of Class Insecta
tmp:
  image: /images/cc_0.png
  legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
  name: Creative Commons Public Domain Dedication (CC0 1.0)
  short: CC0 (1.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '14617'
abstract:
- lang: eng
  text: Sex chromosomes have evolved independently multiple times, but why some are
    conserved for more than 100 million years whereas others turnover rapidly remains
    an open question. Here, we examine the homology of sex chromosomes across nine
    orders of insects, plus the outgroup springtails. We find that the X chromosome
    is likely homologous across insects and springtails; the only exception is in
    the Lepidoptera, which has lost the X and now has a ZZ/ZW sex chromosome system.
    These results suggest the ancestral insect X chromosome has persisted for more
    than 450 million years – the oldest known sex chromosome to date. Further, we
    propose that the shrinking of gene content of the Dipteran X chromosome has allowed
    for a burst of sex-chromosome turnover that is absent from other speciose insect
    orders.
article_processing_charge: No
author:
- first_name: Melissa A
  full_name: Toups, Melissa A
  id: 4E099E4E-F248-11E8-B48F-1D18A9856A87
  last_name: Toups
  orcid: 0000-0002-9752-7380
- first_name: Beatriz
  full_name: Vicoso, Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
citation:
  ama: Toups MA, Vicoso B. The X chromosome of insects likely predates the origin
    of Class Insecta. 2023. doi:<a href="https://doi.org/10.5281/ZENODO.8138705">10.5281/ZENODO.8138705</a>
  apa: Toups, M. A., &#38; Vicoso, B. (2023). The X chromosome of insects likely predates
    the origin of Class Insecta. Zenodo. <a href="https://doi.org/10.5281/ZENODO.8138705">https://doi.org/10.5281/ZENODO.8138705</a>
  chicago: Toups, Melissa A, and Beatriz Vicoso. “The X Chromosome of Insects Likely
    Predates the Origin of Class Insecta.” Zenodo, 2023. <a href="https://doi.org/10.5281/ZENODO.8138705">https://doi.org/10.5281/ZENODO.8138705</a>.
  ieee: M. A. Toups and B. Vicoso, “The X chromosome of insects likely predates the
    origin of Class Insecta.” Zenodo, 2023.
  ista: Toups MA, Vicoso B. 2023. The X chromosome of insects likely predates the
    origin of Class Insecta, Zenodo, <a href="https://doi.org/10.5281/ZENODO.8138705">10.5281/ZENODO.8138705</a>.
  mla: Toups, Melissa A., and Beatriz Vicoso. <i>The X Chromosome of Insects Likely
    Predates the Origin of Class Insecta</i>. Zenodo, 2023, doi:<a href="https://doi.org/10.5281/ZENODO.8138705">10.5281/ZENODO.8138705</a>.
  short: M.A. Toups, B. Vicoso, (2023).
date_created: 2023-11-28T08:04:03Z
date_published: 2023-09-15T00:00:00Z
date_updated: 2025-09-09T13:32:05Z
day: '15'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.5281/ZENODO.8138705
fulldoi: https://doi.org/10.5281/ZENODO.8138705
has_accepted_license: '1'
main_file_link:
- open_access: '1'
  url: https://doi.org/10.5281/zenodo.8138705
month: '09'
oa: 1
oa_version: Published Version
other_data_license: MIT License
publisher: Zenodo
related_material:
  record:
  - id: '14604'
    relation: used_in_publication
    status: public
status: public
title: The X chromosome of insects likely predates the origin of Class Insecta
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '14628'
abstract:
- lang: eng
  text: We introduce a compact, intuitive procedural graph representation for cellular
    metamaterials, which are small-scale, tileable structures that can be architected
    to exhibit many useful material properties. Because the structures’ “architectures”
    vary widely—with elements such as beams, thin shells, and solid bulks—it is difficult
    to explore them using existing representations. Generic approaches like voxel
    grids are versatile, but it is cumbersome to represent and edit individual structures;
    architecture-specific approaches address these issues, but are incompatible with
    one another. By contrast, our procedural graph succinctly represents the construction
    process for any structure using a simple skeleton annotated with spatially varying
    thickness. To express the highly constrained triply periodic minimal surfaces
    (TPMS) in this manner, we present the first fully automated version of the conjugate
    surface construction method, which allows novices to create complex TPMS from
    intuitive input. We demonstrate our representation’s expressiveness, accuracy,
    and compactness by constructing a wide range of established structures and hundreds
    of novel structures with diverse architectures and material properties. We also
    conduct a user study to verify our representation’s ease-of-use and ability to
    expand engineers’ capacity for exploration.
acknowledgement: "The authors thank Mina Konaković Luković and Michael Foshey for
  their early contributions to this project, David Palmer and Paul Zhang for their
  insightful discussions about minimal surfaces and the CSCM, Julian Panetta for providing
  the Elastic Textures code, and Hannes Hergeth for his feedback and support. We also
  thank our user study participants and anonymous reviewers.\r\nThis material is based
  upon work supported by the National Science Foundation\r\n(NSF) Graduate Research
  Fellowship under Grant No. 2141064; the MIT Morningside\r\nAcademy for Design Fellowship;
  the Defense Advanced Research Projects Agency\r\n(DARPA) Grant No. FA8750-20-C-0075;
  the ERC Consolidator Grant No. 101045083,\r\n“CoDiNA: Computational Discovery of
  Numerical Algorithms for Animation and Simulation of Natural Phenomena”; and the
  NewSat project, which is co-funded by the Operational Program for Competitiveness
  and Internationalisation (COMPETE2020), Portugal 2020, the European Regional Development
  Fund (ERDF), and the Portuguese Foundation for Science and Technology (FTC) under
  the MIT Portugal program."
article_number: '168'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Liane
  full_name: Makatura, Liane
  last_name: Makatura
- first_name: Bohan
  full_name: Wang, Bohan
  last_name: Wang
- first_name: Yi-Lu
  full_name: Chen, Yi-Lu
  id: 0b467602-dbcd-11ea-9d1d-ed480aa46b70
  last_name: Chen
- first_name: Bolei
  full_name: Deng, Bolei
  last_name: Deng
- first_name: Christopher J
  full_name: Wojtan, Christopher J
  id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
  last_name: Wojtan
  orcid: 0000-0001-6646-5546
- first_name: Bernd
  full_name: Bickel, Bernd
  id: 49876194-F248-11E8-B48F-1D18A9856A87
  last_name: Bickel
  orcid: 0000-0001-6511-9385
- first_name: Wojciech
  full_name: Matusik, Wojciech
  last_name: Matusik
citation:
  ama: 'Makatura L, Wang B, Chen Y-L, et al. Procedural metamaterials: A unified procedural
    graph for metamaterial design. <i>ACM Transactions on Graphics</i>. 2023;42(5).
    doi:<a href="https://doi.org/10.1145/3605389">10.1145/3605389</a>'
  apa: 'Makatura, L., Wang, B., Chen, Y.-L., Deng, B., Wojtan, C., Bickel, B., &#38;
    Matusik, W. (2023). Procedural metamaterials: A unified procedural graph for metamaterial
    design. <i>ACM Transactions on Graphics</i>. Association for Computing Machinery.
    <a href="https://doi.org/10.1145/3605389">https://doi.org/10.1145/3605389</a>'
  chicago: 'Makatura, Liane, Bohan Wang, Yi-Lu Chen, Bolei Deng, Chris Wojtan, Bernd
    Bickel, and Wojciech Matusik. “Procedural Metamaterials: A Unified Procedural
    Graph for Metamaterial Design.” <i>ACM Transactions on Graphics</i>. Association
    for Computing Machinery, 2023. <a href="https://doi.org/10.1145/3605389">https://doi.org/10.1145/3605389</a>.'
  ieee: 'L. Makatura <i>et al.</i>, “Procedural metamaterials: A unified procedural
    graph for metamaterial design,” <i>ACM Transactions on Graphics</i>, vol. 42,
    no. 5. Association for Computing Machinery, 2023.'
  ista: 'Makatura L, Wang B, Chen Y-L, Deng B, Wojtan C, Bickel B, Matusik W. 2023.
    Procedural metamaterials: A unified procedural graph for metamaterial design.
    ACM Transactions on Graphics. 42(5), 168.'
  mla: 'Makatura, Liane, et al. “Procedural Metamaterials: A Unified Procedural Graph
    for Metamaterial Design.” <i>ACM Transactions on Graphics</i>, vol. 42, no. 5,
    168, Association for Computing Machinery, 2023, doi:<a href="https://doi.org/10.1145/3605389">10.1145/3605389</a>.'
  short: L. Makatura, B. Wang, Y.-L. Chen, B. Deng, C. Wojtan, B. Bickel, W. Matusik,
    ACM Transactions on Graphics 42 (2023).
date_created: 2023-11-29T15:02:03Z
date_published: 2023-10-01T00:00:00Z
date_updated: 2025-09-09T13:33:58Z
day: '01'
ddc:
- '531'
- '006'
department:
- _id: GradSch
- _id: ChWo
- _id: BeBi
doi: 10.1145/3605389
external_id:
  isi:
  - '001086833300007'
file:
- access_level: open_access
  checksum: 0192f597d7a2ceaf89baddfd6190d4c8
  content_type: application/zip
  creator: yichen
  date_created: 2023-11-29T15:16:01Z
  date_updated: 2023-11-29T15:16:01Z
  file_id: '14630'
  file_name: tog-22-0089-File004.zip
  file_size: 95467870
  relation: main_file
  success: 1
- access_level: open_access
  checksum: 7fb024963be81933494f38de191e4710
  content_type: application/zip
  creator: yichen
  date_created: 2023-11-29T15:16:01Z
  date_updated: 2023-11-29T15:16:01Z
  file_id: '14631'
  file_name: tog-22-0089-File005.zip
  file_size: 103731880
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  success: 1
- access_level: open_access
  checksum: b7d6829ce396e21cac9fae0ec7130a6b
  content_type: application/pdf
  creator: dernst
  date_created: 2023-12-04T08:04:14Z
  date_updated: 2023-12-04T08:04:14Z
  file_id: '14638'
  file_name: 2023_ACMToG_Makatura.pdf
  file_size: 57067476
  relation: main_file
  success: 1
file_date_updated: 2023-12-04T08:04:14Z
fulldoi: https://doi.org/10.1145/3605389
has_accepted_license: '1'
intvolume: '        42'
isi: 1
issue: '5'
keyword:
- Computer Graphics and Computer-Aided Design
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 34bc2376-11ca-11ed-8bc3-9a3b3961a088
  grant_number: '101045083'
  name: Computational Discovery of Numerical Algorithms for Animation and Simulation
    of Natural Phenomena
publication: ACM Transactions on Graphics
publication_identifier:
  eissn:
  - 1557-7368
  issn:
  - 0730-0301
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Procedural metamaterials: A unified procedural graph for metamaterial design'
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 42
year: '2023'
...
---
_id: '14639'
abstract:
- lang: eng
  text: "Background: Biallelic variants in OGDHL, encoding part of the α-ketoglutarate
    dehydrogenase complex, have been associated with highly heterogeneous neurological
    and neurodevelopmental disorders. However, the validity of this association remains
    to be confirmed. A second OGDHL patient cohort was recruited to carefully assess
    the gene-disease relationship.\r\nMethods: Using an unbiased genotype-first approach,
    we screened large, multiethnic aggregated sequencing datasets worldwide for biallelic
    OGDHL variants. We used CRISPR/Cas9 to generate zebrafish knockouts of ogdhl,
    ogdh paralogs, and dhtkd1 to investigate functional relationships and impact during
    development. Functional complementation with patient variant transcripts was conducted
    to systematically assess protein functionality as a readout for pathogenicity.\r\nResults:
    A cohort of 14 individuals from 12 unrelated families exhibited highly variable
    clinical phenotypes, with the majority of them presenting at least one additional
    variant, potentially accounting for a blended phenotype and complicating phenotypic
    understanding. We also uncovered extreme clinical heterogeneity and high allele
    frequencies, occasionally incompatible with a fully penetrant recessive disorder.
    Human cDNA of previously described and new variants were tested in an ogdhl zebrafish
    knockout model, adding functional evidence for variant reclassification. We disclosed
    evidence of hypomorphic alleles as well as a loss-of-function variant without
    deleterious effects in zebrafish variant testing also showing discordant familial
    segregation, challenging the relationship of OGDHL as a conventional Mendelian
    gene. Going further, we uncovered evidence for a complex compensatory relationship
    among OGDH, OGDHL, and DHTKD1 isoenzymes that are associated with neurodevelopmental
    disorders and exhibit complex transcriptional compensation patterns with partial
    functional redundancy.\r\nConclusions: Based on the results of genetic, clinical,
    and functional studies, we formed three hypotheses in which to frame observations:
    biallelic OGDHL variants lead to a highly variable monogenic disorder, variants
    in OGDHL are following a complex pattern of inheritance, or they may not be causative
    at all. Our study further highlights the continuing challenges of assessing the
    validity of reported disease-gene associations and effects of variants identified
    in these genes. This is particularly more complicated in making genetic diagnoses
    based on identification of variants in genes presenting a highly heterogenous
    phenotype such as “OGDHL-related disorders”."
article_number: '102'
article_processing_charge: Yes
article_type: original
author:
- first_name: Sheng-Jia
  full_name: Lin, Sheng-Jia
  last_name: Lin
- first_name: Barbara
  full_name: Vona, Barbara
  last_name: Vona
- first_name: Tracy
  full_name: Lau, Tracy
  last_name: Lau
- first_name: Kevin
  full_name: Huang, Kevin
  id: 3b3d2888-1ff6-11ee-9fa6-8f209ca91fe3
  last_name: Huang
  orcid: 0000-0002-2512-7812
- first_name: Maha S.
  full_name: Zaki, Maha S.
  last_name: Zaki
- first_name: Huda Shujaa
  full_name: Aldeen, Huda Shujaa
  last_name: Aldeen
- first_name: Ehsan Ghayoor
  full_name: Karimiani, Ehsan Ghayoor
  last_name: Karimiani
- first_name: Clarissa
  full_name: Rocca, Clarissa
  last_name: Rocca
- first_name: Mahmoud M.
  full_name: Noureldeen, Mahmoud M.
  last_name: Noureldeen
- first_name: Ahmed K.
  full_name: Saad, Ahmed K.
  last_name: Saad
- first_name: Cassidy
  full_name: Petree, Cassidy
  last_name: Petree
- first_name: Tobias
  full_name: Bartolomaeus, Tobias
  last_name: Bartolomaeus
- first_name: Rami
  full_name: Abou Jamra, Rami
  last_name: Abou Jamra
- first_name: Giovanni
  full_name: Zifarelli, Giovanni
  last_name: Zifarelli
- first_name: Aditi
  full_name: Gotkhindikar, Aditi
  last_name: Gotkhindikar
- first_name: Ingrid M.
  full_name: Wentzensen, Ingrid M.
  last_name: Wentzensen
- first_name: Mingjuan
  full_name: Liao, Mingjuan
  last_name: Liao
- first_name: Emalyn Elise
  full_name: Cork, Emalyn Elise
  last_name: Cork
- first_name: Pratishtha
  full_name: Varshney, Pratishtha
  last_name: Varshney
- first_name: Narges
  full_name: Hashemi, Narges
  last_name: Hashemi
- first_name: Mohammad Hasan
  full_name: Mohammadi, Mohammad Hasan
  last_name: Mohammadi
- first_name: Aboulfazl
  full_name: Rad, Aboulfazl
  last_name: Rad
- first_name: Juanita
  full_name: Neira, Juanita
  last_name: Neira
- first_name: Mehran Beiraghi
  full_name: Toosi, Mehran Beiraghi
  last_name: Toosi
- first_name: Cordula
  full_name: Knopp, Cordula
  last_name: Knopp
- first_name: Ingo
  full_name: Kurth, Ingo
  last_name: Kurth
- first_name: Thomas D.
  full_name: Challman, Thomas D.
  last_name: Challman
- first_name: Rebecca
  full_name: Smith, Rebecca
  last_name: Smith
- first_name: Asmahan
  full_name: Abdalla, Asmahan
  last_name: Abdalla
- first_name: Thomas
  full_name: Haaf, Thomas
  last_name: Haaf
- first_name: Mohnish
  full_name: Suri, Mohnish
  last_name: Suri
- first_name: Manali
  full_name: Joshi, Manali
  last_name: Joshi
- first_name: Wendy K.
  full_name: Chung, Wendy K.
  last_name: Chung
- first_name: Andres
  full_name: Moreno-De-Luca, Andres
  last_name: Moreno-De-Luca
- first_name: Henry
  full_name: Houlden, Henry
  last_name: Houlden
- first_name: Reza
  full_name: Maroofian, Reza
  last_name: Maroofian
- first_name: Gaurav K.
  full_name: Varshney, Gaurav K.
  last_name: Varshney
citation:
  ama: Lin S-J, Vona B, Lau T, et al. Evaluating the association of biallelic OGDHL
    variants with significant phenotypic heterogeneity. <i>Genome Medicine</i>. 2023;15.
    doi:<a href="https://doi.org/10.1186/s13073-023-01258-4">10.1186/s13073-023-01258-4</a>
  apa: Lin, S.-J., Vona, B., Lau, T., Huang, K., Zaki, M. S., Aldeen, H. S., … Varshney,
    G. K. (2023). Evaluating the association of biallelic OGDHL variants with significant
    phenotypic heterogeneity. <i>Genome Medicine</i>. Springer Nature. <a href="https://doi.org/10.1186/s13073-023-01258-4">https://doi.org/10.1186/s13073-023-01258-4</a>
  chicago: Lin, Sheng-Jia, Barbara Vona, Tracy Lau, Kevin Huang, Maha S. Zaki, Huda
    Shujaa Aldeen, Ehsan Ghayoor Karimiani, et al. “Evaluating the Association of
    Biallelic OGDHL Variants with Significant Phenotypic Heterogeneity.” <i>Genome
    Medicine</i>. Springer Nature, 2023. <a href="https://doi.org/10.1186/s13073-023-01258-4">https://doi.org/10.1186/s13073-023-01258-4</a>.
  ieee: S.-J. Lin <i>et al.</i>, “Evaluating the association of biallelic OGDHL variants
    with significant phenotypic heterogeneity,” <i>Genome Medicine</i>, vol. 15. Springer
    Nature, 2023.
  ista: Lin S-J, Vona B, Lau T, Huang K, Zaki MS, Aldeen HS, Karimiani EG, Rocca C,
    Noureldeen MM, Saad AK, Petree C, Bartolomaeus T, Abou Jamra R, Zifarelli G, Gotkhindikar
    A, Wentzensen IM, Liao M, Cork EE, Varshney P, Hashemi N, Mohammadi MH, Rad A,
    Neira J, Toosi MB, Knopp C, Kurth I, Challman TD, Smith R, Abdalla A, Haaf T,
    Suri M, Joshi M, Chung WK, Moreno-De-Luca A, Houlden H, Maroofian R, Varshney
    GK. 2023. Evaluating the association of biallelic OGDHL variants with significant
    phenotypic heterogeneity. Genome Medicine. 15, 102.
  mla: Lin, Sheng-Jia, et al. “Evaluating the Association of Biallelic OGDHL Variants
    with Significant Phenotypic Heterogeneity.” <i>Genome Medicine</i>, vol. 15, 102,
    Springer Nature, 2023, doi:<a href="https://doi.org/10.1186/s13073-023-01258-4">10.1186/s13073-023-01258-4</a>.
  short: S.-J. Lin, B. Vona, T. Lau, K. Huang, M.S. Zaki, H.S. Aldeen, E.G. Karimiani,
    C. Rocca, M.M. Noureldeen, A.K. Saad, C. Petree, T. Bartolomaeus, R. Abou Jamra,
    G. Zifarelli, A. Gotkhindikar, I.M. Wentzensen, M. Liao, E.E. Cork, P. Varshney,
    N. Hashemi, M.H. Mohammadi, A. Rad, J. Neira, M.B. Toosi, C. Knopp, I. Kurth,
    T.D. Challman, R. Smith, A. Abdalla, T. Haaf, M. Suri, M. Joshi, W.K. Chung, A.
    Moreno-De-Luca, H. Houlden, R. Maroofian, G.K. Varshney, Genome Medicine 15 (2023).
date_created: 2023-12-04T08:10:55Z
date_published: 2023-11-23T00:00:00Z
date_updated: 2023-12-04T08:17:22Z
day: '23'
ddc:
- '570'
doi: 10.1186/s13073-023-01258-4
extern: '1'
file:
- access_level: open_access
  checksum: 279efd212005549aba817a487d56d363
  content_type: application/pdf
  creator: dernst
  date_created: 2023-12-04T08:15:43Z
  date_updated: 2023-12-04T08:15:43Z
  file_id: '14640'
  file_name: 2023_GenomeMed_Lin.pdf
  file_size: 14791081
  relation: main_file
  success: 1
file_date_updated: 2023-12-04T08:15:43Z
fulldoi: https://doi.org/10.1186/s13073-023-01258-4
has_accepted_license: '1'
intvolume: '        15'
keyword:
- Genetics (clinical)
- Genetics
- Molecular Biology
- Molecular Medicine
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: Genome Medicine
publication_identifier:
  issn:
  - 1756-994X
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Evaluating the association of biallelic OGDHL variants with significant phenotypic
  heterogeneity
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2023'
...
---
_id: '14644'
abstract:
- lang: eng
  text: Transcription by RNA polymerase II (Pol II) can be repressed by noncoding
    RNA, including the human RNA Alu. However, the mechanism by which endogenous RNAs
    repress transcription remains unclear. Here we present cryo-electron microscopy
    structures of Pol II bound to Alu RNA, which reveal that Alu RNA mimics how DNA
    and RNA bind to Pol II during transcription elongation. Further, we show how domains
    of the general transcription factor TFIIF affect complex dynamics and control
    repressive activity. Together, we reveal how a non-coding RNA can regulate mammalian
    gene expression.
acknowledged_ssus:
- _id: LifeSc
- _id: EM-Fac
- _id: PreCl
acknowledgement: "We thank B. Kaczmarek and other members of the Bernecky lab for
  helpful discussions. We thank V.-V. Hodirnau for SerialEM data collection and support
  with EPU data collection. We thank D. Slade for the wild type TFIIF expression\r\nplasmid.
  We thank N. Thompson and R. Burgess for the 8WG16 hybridoma cell line. We thank
  C. Plaschka and M. Loose for critical reading of the manuscript. This work was supported
  by Austrian Science Fund (FWF) grant P34185. This research was further supported
  by the Scientific Service Units (SSU) of IST Austria through resources provided
  by the Lab Support Facility (LSF), Electron Microscopy Facility (EMF), Scientific
  Computing (SciComp), and the Preclinical Facility (PCF)."
article_processing_charge: No
author:
- first_name: Katarina
  full_name: Tluckova, Katarina
  id: 4AC7D980-F248-11E8-B48F-1D18A9856A87
  last_name: Tluckova
- first_name: Anita P
  full_name: Testa Salmazo, Anita P
  id: 41F1F098-F248-11E8-B48F-1D18A9856A87
  last_name: Testa Salmazo
- first_name: Carrie A
  full_name: Bernecky, Carrie A
  id: 2CB9DFE2-F248-11E8-B48F-1D18A9856A87
  last_name: Bernecky
  orcid: 0000-0003-0893-7036
citation:
  ama: Tluckova K, Testa Salmazo AP, Bernecky C. Mechanism of mammalian transcriptional
    repression by noncoding RNA. doi:<a href="https://doi.org/10.15479/AT:ISTA:14644">10.15479/AT:ISTA:14644</a>
  apa: Tluckova, K., Testa Salmazo, A. P., &#38; Bernecky, C. (n.d.). Mechanism of
    mammalian transcriptional repression by noncoding RNA. Institute of Science and
    Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:14644">https://doi.org/10.15479/AT:ISTA:14644</a>
  chicago: Tluckova, Katarina, Anita P Testa Salmazo, and Carrie Bernecky. “Mechanism
    of Mammalian Transcriptional Repression by Noncoding RNA.” Institute of Science
    and Technology Austria, n.d. <a href="https://doi.org/10.15479/AT:ISTA:14644">https://doi.org/10.15479/AT:ISTA:14644</a>.
  ieee: K. Tluckova, A. P. Testa Salmazo, and C. Bernecky, “Mechanism of mammalian
    transcriptional repression by noncoding RNA.” Institute of Science and Technology
    Austria.
  ista: Tluckova K, Testa Salmazo AP, Bernecky C. Mechanism of mammalian transcriptional
    repression by noncoding RNA. <a href="https://doi.org/10.15479/AT:ISTA:14644">10.15479/AT:ISTA:14644</a>.
  mla: Tluckova, Katarina, et al. <i>Mechanism of Mammalian Transcriptional Repression
    by Noncoding RNA</i>. Institute of Science and Technology Austria, doi:<a href="https://doi.org/10.15479/AT:ISTA:14644">10.15479/AT:ISTA:14644</a>.
  short: K. Tluckova, A.P. Testa Salmazo, C. Bernecky, (n.d.).
corr_author: '1'
date_created: 2023-12-04T14:51:00Z
date_published: 2023-12-05T00:00:00Z
date_updated: 2025-11-20T10:28:37Z
day: '05'
ddc:
- '572'
doi: 10.15479/AT:ISTA:14644
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file_date_updated: 2023-12-05T10:37:02Z
fulldoi: https://doi.org/10.15479/AT:ISTA:14644
has_accepted_license: '1'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Submitted Version
project:
- _id: c08a6700-5a5b-11eb-8a69-82a722b2bc30
  grant_number: P34185
  name: Regulation of mammalian transcription by noncoding RNA
publication_status: draft
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '18778'
    relation: later_version
    status: public
status: public
title: Mechanism of mammalian transcriptional repression by noncoding RNA
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '14650'
abstract:
- lang: eng
  text: We study the out-of-equilibrium quantum dynamics of dipolar polarons, i.e.,
    impurities immersed in a dipolar Bose-Einstein condensate, after a quench of the
    impurity-boson interaction. We show that the dipolar nature of the condensate
    and of the impurity results in anisotropic relaxation dynamics, in particular,
    anisotropic dressing of the polaron. More relevantly for cold-atom setups, quench
    dynamics is strongly affected by the interplay between dipolar anisotropy and
    trap geometry. Our findings pave the way for simulating impurities in anisotropic
    media utilizing experiments with dipolar mixtures.
acknowledgement: "We thank Lauriane Chomaz for useful discussions and comments on
  the manuscript. We also\r\nthank Ragheed Al Hyder for comments on the manuscript.\r\nG.B.
  acknowledges support from the Austrian Science Fund (FWF),\r\nunder Project No.
  M2641-N27. This work is supported by the Deutsche Forschungsgemeinschaft (DFG, German
  Research Foundation) under Germany’s Excellence Strategy EXC2181/1-\r\n390900948
  (the Heidelberg STRUCTURES Excellence Cluster). A. G. V. acknowledges support from
  the European Union’s Horizon 2020 research and innovation programme under the\r\nMarie
  Skłodowska-Curie Grant Agreement No. 754411. L.A.P.A acknowledges by the PNRR\r\nMUR
  project PE0000023 - NQSTI and the Deutsche Forschungsgemeinschaft (DFG, German\r\nResearch
  Foundation) under Germany’s Excellence Strategy - EXC - 2123 Quantum Frontiers390837967
  and FOR2247."
article_number: '232'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Artem
  full_name: Volosniev, Artem
  id: 37D278BC-F248-11E8-B48F-1D18A9856A87
  last_name: Volosniev
  orcid: 0000-0003-0393-5525
- first_name: Giacomo
  full_name: Bighin, Giacomo
  id: 4CA96FD4-F248-11E8-B48F-1D18A9856A87
  last_name: Bighin
  orcid: 0000-0001-8823-9777
- first_name: Luis
  full_name: Santos, Luis
  last_name: Santos
- first_name: Luisllu A.
  full_name: Peña Ardila, Luisllu A.
  last_name: Peña Ardila
citation:
  ama: Volosniev A, Bighin G, Santos L, Peña Ardila LA. Non-equilibrium dynamics of
    dipolar polarons. <i>SciPost Physics</i>. 2023;15(6). doi:<a href="https://doi.org/10.21468/scipostphys.15.6.232">10.21468/scipostphys.15.6.232</a>
  apa: Volosniev, A., Bighin, G., Santos, L., &#38; Peña Ardila, L. A. (2023). Non-equilibrium
    dynamics of dipolar polarons. <i>SciPost Physics</i>. SciPost Foundation. <a href="https://doi.org/10.21468/scipostphys.15.6.232">https://doi.org/10.21468/scipostphys.15.6.232</a>
  chicago: Volosniev, Artem, Giacomo Bighin, Luis Santos, and Luisllu A. Peña Ardila.
    “Non-Equilibrium Dynamics of Dipolar Polarons.” <i>SciPost Physics</i>. SciPost
    Foundation, 2023. <a href="https://doi.org/10.21468/scipostphys.15.6.232">https://doi.org/10.21468/scipostphys.15.6.232</a>.
  ieee: A. Volosniev, G. Bighin, L. Santos, and L. A. Peña Ardila, “Non-equilibrium
    dynamics of dipolar polarons,” <i>SciPost Physics</i>, vol. 15, no. 6. SciPost
    Foundation, 2023.
  ista: Volosniev A, Bighin G, Santos L, Peña Ardila LA. 2023. Non-equilibrium dynamics
    of dipolar polarons. SciPost Physics. 15(6), 232.
  mla: Volosniev, Artem, et al. “Non-Equilibrium Dynamics of Dipolar Polarons.” <i>SciPost
    Physics</i>, vol. 15, no. 6, 232, SciPost Foundation, 2023, doi:<a href="https://doi.org/10.21468/scipostphys.15.6.232">10.21468/scipostphys.15.6.232</a>.
  short: A. Volosniev, G. Bighin, L. Santos, L.A. Peña Ardila, SciPost Physics 15
    (2023).
corr_author: '1'
date_created: 2023-12-10T13:03:07Z
date_published: 2023-12-07T00:00:00Z
date_updated: 2025-09-09T13:34:34Z
day: '07'
ddc:
- '530'
department:
- _id: MiLe
doi: 10.21468/scipostphys.15.6.232
ec_funded: 1
external_id:
  arxiv:
  - '2305.17969'
  isi:
  - '001121864100003'
file:
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  date_created: 2023-12-11T07:42:04Z
  date_updated: 2023-12-11T07:42:04Z
  file_id: '14669'
  file_name: 2023_SciPostPhysics_Volosniev.pdf
  file_size: 3543541
  relation: main_file
  success: 1
file_date_updated: 2023-12-11T07:42:04Z
fulldoi: https://doi.org/10.21468/scipostphys.15.6.232
has_accepted_license: '1'
intvolume: '        15'
isi: 1
issue: '6'
keyword:
- General Physics and Astronomy
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 26986C82-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: M02641
  name: A path-integral approach to composite impurities
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: SciPost Physics
publication_identifier:
  issn:
  - 2542-4653
publication_status: published
publisher: SciPost Foundation
quality_controlled: '1'
scopus_import: '1'
status: public
title: Non-equilibrium dynamics of dipolar polarons
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 15
year: '2023'
...
---
OA_place: publisher
_id: '14651'
abstract:
- lang: eng
  text: 'For self-incompatibility (SI) to be stable in a population, theory predicts
    that sufficient inbreeding depression (ID) is required: the fitness of offspring
    from self-mated individuals must be low enough to prevent the spread of self-compatibility
    (SC). Reviews of natural plant populations have supported this theory, with SI
    species generally showing high levels of ID. However, there is thought to be an
    under-sampling of self-incompatible taxa in the current literature. In this thesis,
    I study inbreeding depression in the SI plant species Antirrhinum majus using
    both greenhouse crosses and a large collected field dataset. Additionally, the
    gametophytic S-locus of A. majus is highly heterozygous and polymorphic, thus
    making assembly and discovery of S-alleles very difficult. Here, 206 new alleles
    of the male component SLFs are presented, along with a phylogeny showing the high
    conservation with alleles from another Antirrhinum species. Lastly, selected sites
    within the protein structure of SLFs are investigated, with one site in particular
    highlighted as potentially being involved in the SI recognition mechanism.'
acknowledged_ssus:
- _id: ScienComp
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Louise S
  full_name: Arathoon, Louise S
  id: 2CFCFF98-F248-11E8-B48F-1D18A9856A87
  last_name: Arathoon
  orcid: 0000-0003-1771-714X
citation:
  ama: Arathoon LS. Investigating inbreeding depression and the self-incompatibility
    locus of Antirrhinum majus. 2023. doi:<a href="https://doi.org/10.15479/at:ista:14651">10.15479/at:ista:14651</a>
  apa: Arathoon, L. S. (2023). <i>Investigating inbreeding depression and the self-incompatibility
    locus of Antirrhinum majus</i>. Institute of Science and Technology Austria. <a
    href="https://doi.org/10.15479/at:ista:14651">https://doi.org/10.15479/at:ista:14651</a>
  chicago: Arathoon, Louise S. “Investigating Inbreeding Depression and the Self-Incompatibility
    Locus of Antirrhinum Majus.” Institute of Science and Technology Austria, 2023.
    <a href="https://doi.org/10.15479/at:ista:14651">https://doi.org/10.15479/at:ista:14651</a>.
  ieee: L. S. Arathoon, “Investigating inbreeding depression and the self-incompatibility
    locus of Antirrhinum majus,” Institute of Science and Technology Austria, 2023.
  ista: Arathoon LS. 2023. Investigating inbreeding depression and the self-incompatibility
    locus of Antirrhinum majus. Institute of Science and Technology Austria.
  mla: Arathoon, Louise S. <i>Investigating Inbreeding Depression and the Self-Incompatibility
    Locus of Antirrhinum Majus</i>. Institute of Science and Technology Austria, 2023,
    doi:<a href="https://doi.org/10.15479/at:ista:14651">10.15479/at:ista:14651</a>.
  short: L.S. Arathoon, Investigating Inbreeding Depression and the Self-Incompatibility
    Locus of Antirrhinum Majus, Institute of Science and Technology Austria, 2023.
corr_author: '1'
date_created: 2023-12-11T19:30:37Z
date_published: 2023-12-12T00:00:00Z
date_updated: 2026-04-07T13:28:30Z
day: '12'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: NiBa
doi: 10.15479/at:ista:14651
ec_funded: 1
file:
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  date_created: 2023-12-13T15:37:55Z
  date_updated: 2023-12-13T15:37:55Z
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  file_name: Phd_Thesis_LA.pdf
  file_size: 34101468
  relation: main_file
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  content_type: application/zip
  creator: larathoo
  date_created: 2023-12-11T19:24:59Z
  date_updated: 2023-12-14T08:58:18Z
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  file_size: 10713896
  relation: supplementary_material
file_date_updated: 2023-12-14T08:58:18Z
fulldoi: https://doi.org/10.15479/at:ista:14651
has_accepted_license: '1'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: '96'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '11411'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
title: Investigating inbreeding depression and the self-incompatibility locus of Antirrhinum
  majus
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2023'
...
---
_id: '14654'
abstract:
- lang: eng
  text: Two assumptions commonly applied in convection schemes—the diagnostic and
    quasi-equilibrium assumptions—imply that convective activity (e.g., convective
    precipitation) is controlled only by the large-scale (macrostate) environment
    at the time. In contrast, numerical experiments indicate a “memory” or dependence
    of convection also on its own previous activity whereby subgrid-scale (microstate)
    structures boost but are also boosted by convection. In this study we investigated
    this memory by comparing single-column model behavior in two idealized tests previously
    executed by a cloud-resolving model (CRM). Conventional convection schemes that
    employ the diagnostic assumption fail to reproduce the CRM behavior. The memory-capable
    org and Laboratoire de Météorologie Dynamique Zoom cold pool schemes partially
    capture the behavior, but fail to fully exhibit the strong reinforcing feedbacks
    implied by the CRM. Analysis of this failure suggests that it is because the CRM
    supports a linear (or superlinear) dependence of the subgrid structure growth
    rate on the precipitation rate, while the org scheme assumes a sublinear dependence.
    Among varying versions of the org scheme, the growth rate of the org variable
    representing subgrid structure is strongly associated with memory strength. These
    results demonstrate the importance of parameterizing convective memory, and the
    ability of idealized tests to reveal shortcomings of convection schemes and constrain
    model structural assumptions.
acknowledgement: YLH is supported by funding from the European Union's Horizon 2020
  research and innovation programme under the Marie Skłodowska-Curie Grant Agreement
  No. 101034413. CJM gratefully acknowledges funding from the European Research Council
  under the European Union's Horizon 2020 research and innovation program (Project
  CLUSTER, Grant Agreement No. 805041). YLH and SCS were supported by the Australian
  Research Council (FL150100035). The authors thank Brian Mapes, David Fuchs and Siwon
  Song for stimulating and helpful discussions. MC warmly thanks the LMD team in Paris
  for their assistance with the LMDZ model. We thank the two anonymous reviewers for
  their constructive comments that greatly improved this manuscript.
article_number: e2023MS003726
article_processing_charge: Yes
article_type: original
author:
- first_name: Yi-Ling
  full_name: Hwong, Yi-Ling
  id: 1217aa61-4dd1-11ec-9ac3-f2ba3f17ee22
  last_name: Hwong
  orcid: 0000-0001-9281-3479
- first_name: M.
  full_name: Colin, M.
  last_name: Colin
- first_name: Philipp
  full_name: Aglas, Philipp
  id: 02eace56-97fc-11ee-b81a-f0939ca85a77
  last_name: Aglas
- first_name: Caroline J
  full_name: Muller, Caroline J
  id: f978ccb0-3f7f-11eb-b193-b0e2bd13182b
  last_name: Muller
  orcid: 0000-0001-5836-5350
- first_name: S. C.
  full_name: Sherwood, S. C.
  last_name: Sherwood
citation:
  ama: Hwong Y-L, Colin M, Aglas P, Muller CJ, Sherwood SC. Assessing memory in convection
    schemes using idealized tests. <i>Journal of Advances in Modeling Earth Systems</i>.
    2023;15(12). doi:<a href="https://doi.org/10.1029/2023MS003726">10.1029/2023MS003726</a>
  apa: Hwong, Y.-L., Colin, M., Aglas, P., Muller, C. J., &#38; Sherwood, S. C. (2023).
    Assessing memory in convection schemes using idealized tests. <i>Journal of Advances
    in Modeling Earth Systems</i>. Wiley. <a href="https://doi.org/10.1029/2023MS003726">https://doi.org/10.1029/2023MS003726</a>
  chicago: Hwong, Yi-Ling, M. Colin, Philipp Aglas, Caroline J Muller, and S. C. Sherwood.
    “Assessing Memory in Convection Schemes Using Idealized Tests.” <i>Journal of
    Advances in Modeling Earth Systems</i>. Wiley, 2023. <a href="https://doi.org/10.1029/2023MS003726">https://doi.org/10.1029/2023MS003726</a>.
  ieee: Y.-L. Hwong, M. Colin, P. Aglas, C. J. Muller, and S. C. Sherwood, “Assessing
    memory in convection schemes using idealized tests,” <i>Journal of Advances in
    Modeling Earth Systems</i>, vol. 15, no. 12. Wiley, 2023.
  ista: Hwong Y-L, Colin M, Aglas P, Muller CJ, Sherwood SC. 2023. Assessing memory
    in convection schemes using idealized tests. Journal of Advances in Modeling Earth
    Systems. 15(12), e2023MS003726.
  mla: Hwong, Yi-Ling, et al. “Assessing Memory in Convection Schemes Using Idealized
    Tests.” <i>Journal of Advances in Modeling Earth Systems</i>, vol. 15, no. 12,
    e2023MS003726, Wiley, 2023, doi:<a href="https://doi.org/10.1029/2023MS003726">10.1029/2023MS003726</a>.
  short: Y.-L. Hwong, M. Colin, P. Aglas, C.J. Muller, S.C. Sherwood, Journal of Advances
    in Modeling Earth Systems 15 (2023).
corr_author: '1'
date_created: 2023-12-10T23:00:57Z
date_published: 2023-12-01T00:00:00Z
date_updated: 2025-09-09T13:35:40Z
day: '01'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1029/2023MS003726
ec_funded: 1
external_id:
  isi:
  - '001110801100001'
file:
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  checksum: 4d060b293da3d203de8769e398edf711
  content_type: application/pdf
  creator: dernst
  date_created: 2023-12-11T08:08:44Z
  date_updated: 2023-12-11T08:08:44Z
  file_id: '14670'
  file_name: 2023_JAMES_Hwong.pdf
  file_size: 2783677
  relation: main_file
  success: 1
file_date_updated: 2023-12-11T08:08:44Z
fulldoi: https://doi.org/10.1029/2023MS003726
has_accepted_license: '1'
intvolume: '        15'
isi: 1
issue: '12'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 629205d8-2b32-11ec-9570-e1356ff73576
  call_identifier: H2020
  grant_number: '805041'
  name: Organization of CLoUdS, and implications of Tropical  cyclones and for the
    Energetics of the tropics, in current and waRming climate
publication: Journal of Advances in Modeling Earth Systems
publication_identifier:
  eissn:
  - 1942-2466
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
  record:
  - id: '14991'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Assessing memory in convection schemes using idealized tests
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 15
year: '2023'
...
---
_id: '14655'
abstract:
- lang: eng
  text: The kinetics of the assembly of semiflexible filaments through end-to-end
    annealing is key to the structure of the cytoskeleton, but is not understood.
    We analyze this problem through scaling theory and simulations, and uncover a
    regime where filaments’ ends find each other through bending fluctuations without
    the need for the whole filament to diffuse. This results in a very substantial
    speedup of assembly in physiological regimes, and could help with understanding
    the dynamics of actin and intermediate filaments in biological processes such
    as wound healing and cell division.
acknowledgement: The authors thank C´ecile Leduc and Duc-Quang Tran for invaluable
  help with understanding the experimental behavior of intermediate filaments, and
  Raphael Voituriez, Nicolas Levernier, and Alexander Grosberg for fruitful discussion
  on the theoretical model. V. S. also thanks Davide Michieletto, Maria Panoukidou,
  and Lorenzo Rovigatti for very helpful suggestions on the simulation model. M. L.
  was supported by Marie Curie Integration Grant No. PCIG12-GA-2012-334053, “Investissements
  d’Avenir” LabEx PALM (ANR-10-LABX- 0039-PALM), ANR Grants No. ANR-15-CE13-0004-03,
  No. ANR-21-CE11-0004-02 and No. ANR-22-CE30-0024, as well as ERC Starting Grant
  No. 677532. M.L.’s group belongs to the CNRS consortium AQV. Part of this work was
  performed using HPC resources from GENCI–IDRIS (Grants No. 2020-A0090712066 and
  No. 2021-A0110712066).
article_number: '228401'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Valerio
  full_name: Sorichetti, Valerio
  id: ef8a92cb-c7b6-11ec-8bea-e1fd5847bc5b
  last_name: Sorichetti
  orcid: 0000-0002-9645-6576
- first_name: Martin
  full_name: Lenz, Martin
  last_name: Lenz
citation:
  ama: Sorichetti V, Lenz M. Transverse fluctuations control the assembly of semiflexible
    filaments. <i>Physical Review Letters</i>. 2023;131(22). doi:<a href="https://doi.org/10.1103/PhysRevLett.131.228401">10.1103/PhysRevLett.131.228401</a>
  apa: Sorichetti, V., &#38; Lenz, M. (2023). Transverse fluctuations control the
    assembly of semiflexible filaments. <i>Physical Review Letters</i>. American Physical
    Society. <a href="https://doi.org/10.1103/PhysRevLett.131.228401">https://doi.org/10.1103/PhysRevLett.131.228401</a>
  chicago: Sorichetti, Valerio, and Martin Lenz. “Transverse Fluctuations Control
    the Assembly of Semiflexible Filaments.” <i>Physical Review Letters</i>. American
    Physical Society, 2023. <a href="https://doi.org/10.1103/PhysRevLett.131.228401">https://doi.org/10.1103/PhysRevLett.131.228401</a>.
  ieee: V. Sorichetti and M. Lenz, “Transverse fluctuations control the assembly of
    semiflexible filaments,” <i>Physical Review Letters</i>, vol. 131, no. 22. American
    Physical Society, 2023.
  ista: Sorichetti V, Lenz M. 2023. Transverse fluctuations control the assembly of
    semiflexible filaments. Physical Review Letters. 131(22), 228401.
  mla: Sorichetti, Valerio, and Martin Lenz. “Transverse Fluctuations Control the
    Assembly of Semiflexible Filaments.” <i>Physical Review Letters</i>, vol. 131,
    no. 22, 228401, American Physical Society, 2023, doi:<a href="https://doi.org/10.1103/PhysRevLett.131.228401">10.1103/PhysRevLett.131.228401</a>.
  short: V. Sorichetti, M. Lenz, Physical Review Letters 131 (2023).
corr_author: '1'
date_created: 2023-12-10T23:00:57Z
date_published: 2023-12-01T00:00:00Z
date_updated: 2025-09-09T13:35:06Z
day: '01'
department:
- _id: AnSa
doi: 10.1103/PhysRevLett.131.228401
external_id:
  arxiv:
  - '2303.03088'
  isi:
  - '001163810200008'
  pmid:
  - '38101392'
fulldoi: https://doi.org/10.1103/PhysRevLett.131.228401
intvolume: '       131'
isi: 1
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2303.03088
month: '12'
oa: 1
oa_version: Preprint
pmid: 1
publication: Physical Review Letters
publication_identifier:
  eissn:
  - 1079-7114
  issn:
  - 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Transverse fluctuations control the assembly of semiflexible filaments
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 131
year: '2023'
...
---
_id: '14658'
abstract:
- lang: eng
  text: "We investigate spin-charge separation of a spin-\r\n1\r\n2\r\n Fermi system
    confined in a triple well where multiple bands are occupied. We assume that our
    finite fermionic system is close to fully spin polarized while being doped by
    a hole and an impurity fermion with opposite spin. Our setup involves ferromagnetic
    couplings among the particles in different bands, leading to the development of
    strong spin-transport correlations in an intermediate interaction regime. Interactions
    are then strong enough to lift the degeneracy among singlet and triplet spin configurations
    in the well of the spin impurity but not strong enough to prohibit hole-induced
    magnetic excitations to the singlet state. Despite the strong spin-hole correlations,
    the system exhibits spin-charge deconfinement allowing for long-range entanglement
    of the spatial and spin degrees of freedom."
acknowledgement: This work has been funded by the Cluster of Excellence “Advanced
  Imaging of Matter” of the Deutsche Forschungsgemeinschaft (DFG)-EXC 2056-Project
  ID No. 390715994. G.M.K. gratefully acknowledges funding from the European Union’s
  Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie
  Grant Agreement No. 101034413.
article_number: '043039'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: J. M.
  full_name: Becker, J. M.
  last_name: Becker
- first_name: Georgios
  full_name: Koutentakis, Georgios
  id: d7b23d3a-9e21-11ec-b482-f76739596b95
  last_name: Koutentakis
- first_name: P.
  full_name: Schmelcher, P.
  last_name: Schmelcher
citation:
  ama: Becker JM, Koutentakis G, Schmelcher P. Spin-charge correlations in finite
    one-dimensional multiband Fermi systems. <i>Physical Review Research</i>. 2023;5(4).
    doi:<a href="https://doi.org/10.1103/PhysRevResearch.5.043039">10.1103/PhysRevResearch.5.043039</a>
  apa: Becker, J. M., Koutentakis, G., &#38; Schmelcher, P. (2023). Spin-charge correlations
    in finite one-dimensional multiband Fermi systems. <i>Physical Review Research</i>.
    American Physical Society. <a href="https://doi.org/10.1103/PhysRevResearch.5.043039">https://doi.org/10.1103/PhysRevResearch.5.043039</a>
  chicago: Becker, J. M., Georgios Koutentakis, and P. Schmelcher. “Spin-Charge Correlations
    in Finite One-Dimensional Multiband Fermi Systems.” <i>Physical Review Research</i>.
    American Physical Society, 2023. <a href="https://doi.org/10.1103/PhysRevResearch.5.043039">https://doi.org/10.1103/PhysRevResearch.5.043039</a>.
  ieee: J. M. Becker, G. Koutentakis, and P. Schmelcher, “Spin-charge correlations
    in finite one-dimensional multiband Fermi systems,” <i>Physical Review Research</i>,
    vol. 5, no. 4. American Physical Society, 2023.
  ista: Becker JM, Koutentakis G, Schmelcher P. 2023. Spin-charge correlations in
    finite one-dimensional multiband Fermi systems. Physical Review Research. 5(4),
    043039.
  mla: Becker, J. M., et al. “Spin-Charge Correlations in Finite One-Dimensional Multiband
    Fermi Systems.” <i>Physical Review Research</i>, vol. 5, no. 4, 043039, American
    Physical Society, 2023, doi:<a href="https://doi.org/10.1103/PhysRevResearch.5.043039">10.1103/PhysRevResearch.5.043039</a>.
  short: J.M. Becker, G. Koutentakis, P. Schmelcher, Physical Review Research 5 (2023).
corr_author: '1'
date_created: 2023-12-10T23:00:58Z
date_published: 2023-10-12T00:00:00Z
date_updated: 2025-04-14T07:54:54Z
day: '12'
ddc:
- '530'
department:
- _id: MiLe
doi: 10.1103/PhysRevResearch.5.043039
ec_funded: 1
external_id:
  arxiv:
  - '2305.09529'
file:
- access_level: open_access
  checksum: ee31c0d0de5d1b65591990ae6705a601
  content_type: application/pdf
  creator: dernst
  date_created: 2023-12-11T10:49:07Z
  date_updated: 2023-12-11T10:49:07Z
  file_id: '14672'
  file_name: 2023_PhysReviewResearch_Becker.pdf
  file_size: 2362158
  relation: main_file
  success: 1
file_date_updated: 2023-12-11T10:49:07Z
fulldoi: https://doi.org/10.1103/PhysRevResearch.5.043039
has_accepted_license: '1'
intvolume: '         5'
issue: '4'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
publication: Physical Review Research
publication_identifier:
  issn:
  - 2643-1564
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Spin-charge correlations in finite one-dimensional multiband Fermi systems
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2023'
...
---
APC_amount: 4800 EUR
OA_place: publisher
OA_type: hybrid
_id: '14659'
abstract:
- lang: eng
  text: Understanding the response of Himalayan glaciers to global warming is vital
    because of their role as a water source for the Asian subcontinent. However, great
    uncertainties still exist on the climate drivers of past and present glacier changes
    across scales. Here, we analyse continuous hourly climate station data from a
    glacierized elevation (Pyramid station, Mount Everest) since 1994 together with
    other ground observations and climate reanalysis. We show that a decrease in maximum
    air temperature and precipitation occurred during the last three decades at Pyramid
    in response to global warming. Reanalysis data suggest a broader occurrence of
    this effect in the glacierized areas of the Himalaya. We hypothesize that the
    counterintuitive cooling is caused by enhanced sensible heat exchange and the
    associated increase in glacier katabatic wind, which draws cool air downward from
    higher elevations. The stronger katabatic winds have also lowered the elevation
    of local wind convergence, thereby diminishing precipitation in glacial areas
    and negatively affecting glacier mass balance. This local cooling may have partially
    preserved glaciers from melting and could help protect the periglacial environment.
acknowledgement: This work was carried out within the framework of the EV-K2-CNR and
  Nepal Academy of Science and Technology. K.Y. was supported by the Second Tibetan
  Plateau Scientific Expedition and Research Program (grant no. 2019QZKK0206). N.C.
  was supported by the project NODES, which has received funding from the MUR–M4C2
  1.5 of PNRR funded by the European Union - NextGeneration EU (Grant agreement no.
  ECS00000036). T.E.S. has received funding from the European Union’s Horizon 2020
  research and innovation programme under the Marie Sklodowska-Curie grant no. 101026058.
  F.P. has received funding from the European Research Council under the European
  Union’s Horizon 2020 research and innovation programme grant no. 772751, RAVEN,
  ‘Rapid mass losses of debris-covered glaciers in High Mountain Asia’ and has been
  supported by the SNSF grant ‘High-elevation precipitation in High Mountain Asia’
  (grant no. 183633). A.A. was supported by the European Union’s Horizon 2020 research
  and innovation program under grant agreement no. 101004156 (CONFESS project) and
  by the European Union’s Horizon Europe research and innovation program under grant
  agreement no. 101081193 (OptimESM project). We thank H. Wehrli for valuable comments
  and suggestions and J. Giannitrapani for the graphic support. We thank A. Da Polenza
  and K. Bista of EV-K2-CNR for believing that studying the high elevations is relevant
  for the whole globe.
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Franco
  full_name: Salerno, Franco
  last_name: Salerno
- first_name: Nicolas
  full_name: Guyennon, Nicolas
  last_name: Guyennon
- first_name: Kun
  full_name: Yang, Kun
  last_name: Yang
- first_name: Thomas
  full_name: Shaw, Thomas
  id: 3caa3f91-1f03-11ee-96ce-e0e553054d6e
  last_name: Shaw
  orcid: 0000-0001-7640-6152
- first_name: Changgui
  full_name: Lin, Changgui
  last_name: Lin
- first_name: Nicola
  full_name: Colombo, Nicola
  last_name: Colombo
- first_name: Emanuele
  full_name: Romano, Emanuele
  last_name: Romano
- first_name: Stephan
  full_name: Gruber, Stephan
  last_name: Gruber
- first_name: Tobias
  full_name: Bolch, Tobias
  last_name: Bolch
- first_name: Andrea
  full_name: Alessandri, Andrea
  last_name: Alessandri
- first_name: Paolo
  full_name: Cristofanelli, Paolo
  last_name: Cristofanelli
- first_name: Davide
  full_name: Putero, Davide
  last_name: Putero
- first_name: Guglielmina
  full_name: Diolaiuti, Guglielmina
  last_name: Diolaiuti
- first_name: Gianni
  full_name: Tartari, Gianni
  last_name: Tartari
- first_name: Gianpietro
  full_name: Verza, Gianpietro
  last_name: Verza
- first_name: Sudeep
  full_name: Thakuri, Sudeep
  last_name: Thakuri
- first_name: Gianpaolo
  full_name: Balsamo, Gianpaolo
  last_name: Balsamo
- first_name: Evan S.
  full_name: Miles, Evan S.
  last_name: Miles
- first_name: Francesca
  full_name: Pellicciotti, Francesca
  id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
  last_name: Pellicciotti
  orcid: 0000-0002-5554-8087
citation:
  ama: Salerno F, Guyennon N, Yang K, et al. Local cooling and drying induced by Himalayan
    glaciers under global warming. <i>Nature Geoscience</i>. 2023;16:1120-1127. doi:<a
    href="https://doi.org/10.1038/s41561-023-01331-y">10.1038/s41561-023-01331-y</a>
  apa: Salerno, F., Guyennon, N., Yang, K., Shaw, T., Lin, C., Colombo, N., … Pellicciotti,
    F. (2023). Local cooling and drying induced by Himalayan glaciers under global
    warming. <i>Nature Geoscience</i>. Springer Nature. <a href="https://doi.org/10.1038/s41561-023-01331-y">https://doi.org/10.1038/s41561-023-01331-y</a>
  chicago: Salerno, Franco, Nicolas Guyennon, Kun Yang, Thomas Shaw, Changgui Lin,
    Nicola Colombo, Emanuele Romano, et al. “Local Cooling and Drying Induced by Himalayan
    Glaciers under Global Warming.” <i>Nature Geoscience</i>. Springer Nature, 2023.
    <a href="https://doi.org/10.1038/s41561-023-01331-y">https://doi.org/10.1038/s41561-023-01331-y</a>.
  ieee: F. Salerno <i>et al.</i>, “Local cooling and drying induced by Himalayan glaciers
    under global warming,” <i>Nature Geoscience</i>, vol. 16. Springer Nature, pp.
    1120–1127, 2023.
  ista: Salerno F, Guyennon N, Yang K, Shaw T, Lin C, Colombo N, Romano E, Gruber
    S, Bolch T, Alessandri A, Cristofanelli P, Putero D, Diolaiuti G, Tartari G, Verza
    G, Thakuri S, Balsamo G, Miles ES, Pellicciotti F. 2023. Local cooling and drying
    induced by Himalayan glaciers under global warming. Nature Geoscience. 16, 1120–1127.
  mla: Salerno, Franco, et al. “Local Cooling and Drying Induced by Himalayan Glaciers
    under Global Warming.” <i>Nature Geoscience</i>, vol. 16, Springer Nature, 2023,
    pp. 1120–27, doi:<a href="https://doi.org/10.1038/s41561-023-01331-y">10.1038/s41561-023-01331-y</a>.
  short: F. Salerno, N. Guyennon, K. Yang, T. Shaw, C. Lin, N. Colombo, E. Romano,
    S. Gruber, T. Bolch, A. Alessandri, P. Cristofanelli, D. Putero, G. Diolaiuti,
    G. Tartari, G. Verza, S. Thakuri, G. Balsamo, E.S. Miles, F. Pellicciotti, Nature
    Geoscience 16 (2023) 1120–1127.
date_created: 2023-12-10T23:00:58Z
date_published: 2023-12-04T00:00:00Z
date_updated: 2025-09-09T13:36:16Z
day: '04'
ddc:
- '550'
department:
- _id: FrPe
doi: 10.1038/s41561-023-01331-y
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  isi:
  - '001112839700003'
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fulldoi: https://doi.org/10.1038/s41561-023-01331-y
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intvolume: '        16'
isi: 1
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 1120-1127
publication: Nature Geoscience
publication_identifier:
  eissn:
  - 1752-0908
  issn:
  - 1752-0894
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - description: News on ISTA website
    relation: press_release
    url: https://ista.ac.at/en/news/wind-of-climate-change/
scopus_import: '1'
status: public
title: Local cooling and drying induced by Himalayan glaciers under global warming
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 16
year: '2023'
...
---
_id: '14661'
abstract:
- lang: eng
  text: 'This paper is concerned with equilibrium configurations of one-dimensional
    particle systems with non-convex nearest-neighbour and next-to-nearest-neighbour
    interactions and its passage to the continuum. The goal is to derive compactness
    results for a Γ-development of the energy with the novelty that external forces
    are allowed. In particular, the forces may depend on Lagrangian or Eulerian coordinates
    and thus may model dead as well as live loads. Our result is based on a new technique
    for deriving compactness results which are required for calculating the first-order
    Γ-limit in the presence of external forces: instead of comparing a configuration
    of n atoms to a global minimizer of the Γ-limit, we compare the configuration
    to a minimizer in some subclass of functions which in some sense are "close to"
    the configuration. The paper is complemented with the study of the minimizers
    of the Γ-limit.'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Marcello
  full_name: Carioni, Marcello
  last_name: Carioni
- first_name: Julian L
  full_name: Fischer, Julian L
  id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
  last_name: Fischer
  orcid: 0000-0002-0479-558X
- first_name: Anja
  full_name: Schlömerkemper, Anja
  last_name: Schlömerkemper
citation:
  ama: 'Carioni M, Fischer JL, Schlömerkemper A. External forces in the continuum
    limit of discrete systems with non-convex interaction potentials: Compactness
    for a Γ-development. <i>Journal of Convex Analysis</i>. 2023;30(1):217-247.'
  apa: 'Carioni, M., Fischer, J. L., &#38; Schlömerkemper, A. (2023). External forces
    in the continuum limit of discrete systems with non-convex interaction potentials:
    Compactness for a Γ-development. <i>Journal of Convex Analysis</i>. Heldermann
    Verlag.'
  chicago: 'Carioni, Marcello, Julian L Fischer, and Anja Schlömerkemper. “External
    Forces in the Continuum Limit of Discrete Systems with Non-Convex Interaction
    Potentials: Compactness for a Γ-Development.” <i>Journal of Convex Analysis</i>.
    Heldermann Verlag, 2023.'
  ieee: 'M. Carioni, J. L. Fischer, and A. Schlömerkemper, “External forces in the
    continuum limit of discrete systems with non-convex interaction potentials: Compactness
    for a Γ-development,” <i>Journal of Convex Analysis</i>, vol. 30, no. 1. Heldermann
    Verlag, pp. 217–247, 2023.'
  ista: 'Carioni M, Fischer JL, Schlömerkemper A. 2023. External forces in the continuum
    limit of discrete systems with non-convex interaction potentials: Compactness
    for a Γ-development. Journal of Convex Analysis. 30(1), 217–247.'
  mla: 'Carioni, Marcello, et al. “External Forces in the Continuum Limit of Discrete
    Systems with Non-Convex Interaction Potentials: Compactness for a Γ-Development.”
    <i>Journal of Convex Analysis</i>, vol. 30, no. 1, Heldermann Verlag, 2023, pp.
    217–47.'
  short: M. Carioni, J.L. Fischer, A. Schlömerkemper, Journal of Convex Analysis 30
    (2023) 217–247.
corr_author: '1'
date_created: 2023-12-10T23:00:59Z
date_published: 2023-01-01T00:00:00Z
date_updated: 2024-10-09T21:07:35Z
day: '01'
department:
- _id: JuFi
external_id:
  arxiv:
  - '1811.09857'
  isi:
  - '001115503400013'
intvolume: '        30'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1811.09857
month: '01'
oa: 1
oa_version: Preprint
page: 217-247
publication: Journal of Convex Analysis
publication_identifier:
  eissn:
  - 2363-6394
  issn:
  - 0944-6532
publication_status: published
publisher: Heldermann Verlag
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'External forces in the continuum limit of discrete systems with non-convex
  interaction potentials: Compactness for a Γ-development'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 30
year: '2023'
...
