---
_id: '12145'
abstract:
- lang: eng
text: In the class of strictly convex smooth boundaries each of which has no strip
around its boundary foliated by invariant curves, we prove that the Taylor coefficients
of the “normalized” Mather’s β-function are invariant under C∞-conjugacies. In
contrast, we prove that any two elliptic billiard maps are C0-conjugate near their
respective boundaries, and C∞-conjugate, near the boundary and away from a line
passing through the center of the underlying ellipse. We also prove that, if the
billiard maps corresponding to two ellipses are topologically conjugate, then
the two ellipses are similar.
acknowledgement: "We are grateful to the anonymous referees for their careful reading
and valuable remarks and\r\ncomments which helped to improve the paper significantly.
We gratefully acknowledge support from the European Research Council (ERC) through
the Advanced Grant “SPERIG” (#885707)."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Edmond
full_name: Koudjinan, Edmond
id: 52DF3E68-AEFA-11EA-95A4-124A3DDC885E
last_name: Koudjinan
orcid: 0000-0003-2640-4049
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
citation:
ama: Koudjinan E, Kaloshin V. On some invariants of Birkhoff billiards under conjugacy.
Regular and Chaotic Dynamics. 2022;27(6):525-537. doi:10.1134/S1560354722050021
apa: Koudjinan, E., & Kaloshin, V. (2022). On some invariants of Birkhoff billiards
under conjugacy. Regular and Chaotic Dynamics. Springer Nature. https://doi.org/10.1134/S1560354722050021
chicago: Koudjinan, Edmond, and Vadim Kaloshin. “On Some Invariants of Birkhoff
Billiards under Conjugacy.” Regular and Chaotic Dynamics. Springer Nature,
2022. https://doi.org/10.1134/S1560354722050021.
ieee: E. Koudjinan and V. Kaloshin, “On some invariants of Birkhoff billiards under
conjugacy,” Regular and Chaotic Dynamics, vol. 27, no. 6. Springer Nature,
pp. 525–537, 2022.
ista: Koudjinan E, Kaloshin V. 2022. On some invariants of Birkhoff billiards under
conjugacy. Regular and Chaotic Dynamics. 27(6), 525–537.
mla: Koudjinan, Edmond, and Vadim Kaloshin. “On Some Invariants of Birkhoff Billiards
under Conjugacy.” Regular and Chaotic Dynamics, vol. 27, no. 6, Springer
Nature, 2022, pp. 525–37, doi:10.1134/S1560354722050021.
short: E. Koudjinan, V. Kaloshin, Regular and Chaotic Dynamics 27 (2022) 525–537.
corr_author: '1'
date_created: 2023-01-12T12:06:49Z
date_published: 2022-10-03T00:00:00Z
date_updated: 2025-04-14T07:53:45Z
day: '03'
department:
- _id: VaKa
doi: 10.1134/S1560354722050021
ec_funded: 1
external_id:
arxiv:
- '2105.14640'
isi:
- '000865267300002'
intvolume: ' 27'
isi: 1
issue: '6'
keyword:
- Mechanical Engineering
- Applied Mathematics
- Mathematical Physics
- Modeling and Simulation
- Statistical and Nonlinear Physics
- Mathematics (miscellaneous)
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2105.14640
month: '10'
oa: 1
oa_version: Preprint
page: 525-537
project:
- _id: 9B8B92DE-BA93-11EA-9121-9846C619BF3A
call_identifier: H2020
grant_number: '885707'
name: Spectral rigidity and integrability for billiards and geodesic flows
publication: Regular and Chaotic Dynamics
publication_identifier:
eissn:
- 1468-4845
issn:
- 1560-3547
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1134/s1560354722060107
scopus_import: '1'
status: public
title: On some invariants of Birkhoff billiards under conjugacy
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 27
year: '2022'
...
---
_id: '12146'
abstract:
- lang: eng
text: 'In this paper, we explore the stability and dynamical relevance of a wide
variety of steady, time-periodic, quasiperiodic, and chaotic flows arising between
orthogonally stretching parallel plates. We first explore the stability of all
the steady flow solution families formerly identified by Ayats et al. [“Flows
between orthogonally stretching parallel plates,” Phys. Fluids 33, 024103 (2021)],
concluding that only the one that originates from the Stokesian approximation
is actually stable. When both plates are shrinking at identical or nearly the
same deceleration rates, this Stokesian flow exhibits a Hopf bifurcation that
leads to stable time-periodic regimes. The resulting time-periodic orbits or flows
are tracked for different Reynolds numbers and stretching rates while monitoring
their Floquet exponents to identify secondary instabilities. It is found that
these time-periodic flows also exhibit Neimark–Sacker bifurcations, generating
stable quasiperiodic flows (tori) that may sometimes give rise to chaotic dynamics
through a Ruelle–Takens–Newhouse scenario. However, chaotic dynamics is unusually
observed, as the quasiperiodic flows generally become phase-locked through a resonance
mechanism before a strange attractor may arise, thus restoring the time-periodicity
of the flow. In this work, we have identified and tracked four different resonance
regions, also known as Arnold tongues or horns. In particular, the 1 : 4 strong
resonance region is explored in great detail, where the identified scenarios are
in very good agreement with normal form theory. '
acknowledgement: "This work was supported by the Spanish MINECO under Grant Nos. FIS2017-85794-P
and PRX18/00179, the Spanish MICINN through Grant No. PID2020-114043GB-I00, and
the\r\nGeneralitat de Catalunya under Grant No. 2017-SGR-785. B.W.’s research was
also supported by the Chinese Scholarship Council through Grant CSC No. 201806440152."
article_number: '114111'
article_processing_charge: No
article_type: original
author:
- first_name: B.
full_name: Wang, B.
last_name: Wang
- first_name: Roger
full_name: Ayats López, Roger
id: ab77522d-073b-11ed-8aff-e71b39258362
last_name: Ayats López
orcid: 0000-0001-6572-0621
- first_name: A.
full_name: Meseguer, A.
last_name: Meseguer
- first_name: F.
full_name: Marques, F.
last_name: Marques
citation:
ama: Wang B, Ayats López R, Meseguer A, Marques F. Phase-locking flows between orthogonally
stretching parallel plates. Physics of Fluids. 2022;34(11). doi:10.1063/5.0124152
apa: Wang, B., Ayats López, R., Meseguer, A., & Marques, F. (2022). Phase-locking
flows between orthogonally stretching parallel plates. Physics of Fluids.
AIP Publishing. https://doi.org/10.1063/5.0124152
chicago: Wang, B., Roger Ayats López, A. Meseguer, and F. Marques. “Phase-Locking
Flows between Orthogonally Stretching Parallel Plates.” Physics of Fluids.
AIP Publishing, 2022. https://doi.org/10.1063/5.0124152.
ieee: B. Wang, R. Ayats López, A. Meseguer, and F. Marques, “Phase-locking flows
between orthogonally stretching parallel plates,” Physics of Fluids, vol.
34, no. 11. AIP Publishing, 2022.
ista: Wang B, Ayats López R, Meseguer A, Marques F. 2022. Phase-locking flows between
orthogonally stretching parallel plates. Physics of Fluids. 34(11), 114111.
mla: Wang, B., et al. “Phase-Locking Flows between Orthogonally Stretching Parallel
Plates.” Physics of Fluids, vol. 34, no. 11, 114111, AIP Publishing, 2022,
doi:10.1063/5.0124152.
short: B. Wang, R. Ayats López, A. Meseguer, F. Marques, Physics of Fluids 34 (2022).
date_created: 2023-01-12T12:06:58Z
date_published: 2022-11-04T00:00:00Z
date_updated: 2023-10-03T11:07:58Z
day: '04'
department:
- _id: BjHo
doi: 10.1063/5.0124152
external_id:
isi:
- '000880665300024'
intvolume: ' 34'
isi: 1
issue: '11'
keyword:
- Condensed Matter Physics
- Fluid Flow and Transfer Processes
- Mechanics of Materials
- Computational Mechanics
- Mechanical Engineering
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://upcommons.upc.edu/handle/2117/385635
month: '11'
oa: 1
oa_version: Submitted Version
publication: Physics of Fluids
publication_identifier:
eissn:
- 1089-7666
issn:
- 1070-6631
publication_status: published
publisher: AIP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Phase-locking flows between orthogonally stretching parallel plates
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 34
year: '2022'
...
---
_id: '12147'
abstract:
- lang: eng
text: Continuous-time neural networks are a class of machine learning systems that
can tackle representation learning on spatiotemporal decision-making tasks. These
models are typically represented by continuous differential equations. However,
their expressive power when they are deployed on computers is bottlenecked by
numerical differential equation solvers. This limitation has notably slowed down
the scaling and understanding of numerous natural physical phenomena such as the
dynamics of nervous systems. Ideally, we would circumvent this bottleneck by solving
the given dynamical system in closed form. This is known to be intractable in
general. Here, we show that it is possible to closely approximate the interaction
between neurons and synapses—the building blocks of natural and artificial neural
networks—constructed by liquid time-constant networks efficiently in closed form.
To this end, we compute a tightly bounded approximation of the solution of an
integral appearing in liquid time-constant dynamics that has had no known closed-form
solution so far. This closed-form solution impacts the design of continuous-time
and continuous-depth neural models. For instance, since time appears explicitly
in closed form, the formulation relaxes the need for complex numerical solvers.
Consequently, we obtain models that are between one and five orders of magnitude
faster in training and inference compared with differential equation-based counterparts.
More importantly, in contrast to ordinary differential equation-based continuous
networks, closed-form networks can scale remarkably well compared with other deep
learning instances. Lastly, as these models are derived from liquid networks,
they show good performance in time-series modelling compared with advanced recurrent
neural network models.
acknowledgement: This research was supported in part by the AI2050 program at Schmidt
Futures (grant G-22-63172), the Boeing Company, and the United States Air Force
Research Laboratory and the United States Air Force Artificial Intelligence Accelerator
and was accomplished under cooperative agreement number FA8750-19-2-1000. The views
and conclusions contained in this document are those of the authors and should not
be interpreted as representing the official policies, either expressed or implied,
of the United States Air Force or the U.S. Government. The U.S. Government is authorized
to reproduce and distribute reprints for Government purposes, notwithstanding any
copyright notation herein. This work was further supported by The Boeing Company
and Office of Naval Research grant N00014-18-1-2830. M.T. is supported by the Poul
Due Jensen Foundation, grant 883901. M.L. was supported in part by the Austrian
Science Fund under grant Z211-N23 (Wittgenstein Award). A.A. was supported by the
National Science Foundation Graduate Research Fellowship Program. We thank T.-H.
Wang, P. Kao, M. Chahine, W. Xiao, X. Li, L. Yin and Y. Ben for useful suggestions
and for testing of CfC models to confirm the results across other domains.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Ramin
full_name: Hasani, Ramin
last_name: Hasani
- first_name: Mathias
full_name: Lechner, Mathias
id: 3DC22916-F248-11E8-B48F-1D18A9856A87
last_name: Lechner
- first_name: Alexander
full_name: Amini, Alexander
last_name: Amini
- first_name: Lucas
full_name: Liebenwein, Lucas
last_name: Liebenwein
- first_name: Aaron
full_name: Ray, Aaron
last_name: Ray
- first_name: Max
full_name: Tschaikowski, Max
last_name: Tschaikowski
- first_name: Gerald
full_name: Teschl, Gerald
last_name: Teschl
- first_name: Daniela
full_name: Rus, Daniela
last_name: Rus
citation:
ama: Hasani R, Lechner M, Amini A, et al. Closed-form continuous-time neural networks.
Nature Machine Intelligence. 2022;4(11):992-1003. doi:10.1038/s42256-022-00556-7
apa: Hasani, R., Lechner, M., Amini, A., Liebenwein, L., Ray, A., Tschaikowski,
M., … Rus, D. (2022). Closed-form continuous-time neural networks. Nature Machine
Intelligence. Springer Nature. https://doi.org/10.1038/s42256-022-00556-7
chicago: Hasani, Ramin, Mathias Lechner, Alexander Amini, Lucas Liebenwein, Aaron
Ray, Max Tschaikowski, Gerald Teschl, and Daniela Rus. “Closed-Form Continuous-Time
Neural Networks.” Nature Machine Intelligence. Springer Nature, 2022. https://doi.org/10.1038/s42256-022-00556-7.
ieee: R. Hasani et al., “Closed-form continuous-time neural networks,” Nature
Machine Intelligence, vol. 4, no. 11. Springer Nature, pp. 992–1003, 2022.
ista: Hasani R, Lechner M, Amini A, Liebenwein L, Ray A, Tschaikowski M, Teschl
G, Rus D. 2022. Closed-form continuous-time neural networks. Nature Machine Intelligence.
4(11), 992–1003.
mla: Hasani, Ramin, et al. “Closed-Form Continuous-Time Neural Networks.” Nature
Machine Intelligence, vol. 4, no. 11, Springer Nature, 2022, pp. 992–1003,
doi:10.1038/s42256-022-00556-7.
short: R. Hasani, M. Lechner, A. Amini, L. Liebenwein, A. Ray, M. Tschaikowski,
G. Teschl, D. Rus, Nature Machine Intelligence 4 (2022) 992–1003.
date_created: 2023-01-12T12:07:21Z
date_published: 2022-11-15T00:00:00Z
date_updated: 2025-04-15T06:26:02Z
day: '15'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1038/s42256-022-00556-7
external_id:
arxiv:
- '2106.13898'
isi:
- '000884215600003'
file:
- access_level: open_access
checksum: b4789122ce04bfb4ac042390f59aaa8b
content_type: application/pdf
creator: dernst
date_created: 2023-01-24T09:49:44Z
date_updated: 2023-01-24T09:49:44Z
file_id: '12355'
file_name: 2022_NatureMachineIntelligence_Hasani.pdf
file_size: 3259553
relation: main_file
success: 1
file_date_updated: 2023-01-24T09:49:44Z
has_accepted_license: '1'
intvolume: ' 4'
isi: 1
issue: '11'
keyword:
- Artificial Intelligence
- Computer Networks and Communications
- Computer Vision and Pattern Recognition
- Human-Computer Interaction
- Software
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 992-1003
project:
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: Formal methods for the design and analysis of complex systems
publication: Nature Machine Intelligence
publication_identifier:
issn:
- 2522-5839
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1038/s42256-022-00597-y
scopus_import: '1'
status: public
title: Closed-form continuous-time neural networks
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 4
year: '2022'
...
---
_id: '12148'
abstract:
- lang: eng
text: 'We prove a general local law for Wigner matrices that optimally handles observables
of arbitrary rank and thus unifies the well-known averaged and isotropic local
laws. As an application, we prove a central limit theorem in quantum unique ergodicity
(QUE): that is, we show that the quadratic forms of a general deterministic matrix
A on the bulk eigenvectors of a Wigner matrix have approximately Gaussian fluctuation.
For the bulk spectrum, we thus generalise our previous result [17] as valid for
test matrices A of large rank as well as the result of Benigni and Lopatto [7]
as valid for specific small-rank observables.'
acknowledgement: L.E. acknowledges support by ERC Advanced Grant ‘RMTBeyond’ No. 101020331.
D.S. acknowledges the support of Dr. Max Rössler, the Walter Haefner Foundation
and the ETH Zürich Foundation.
article_number: e96
article_processing_charge: No
article_type: original
author:
- first_name: Giorgio
full_name: Cipolloni, Giorgio
id: 42198EFA-F248-11E8-B48F-1D18A9856A87
last_name: Cipolloni
orcid: 0000-0002-4901-7992
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Dominik J
full_name: Schröder, Dominik J
id: 408ED176-F248-11E8-B48F-1D18A9856A87
last_name: Schröder
orcid: 0000-0002-2904-1856
citation:
ama: Cipolloni G, Erdös L, Schröder DJ. Rank-uniform local law for Wigner matrices.
Forum of Mathematics, Sigma. 2022;10. doi:10.1017/fms.2022.86
apa: Cipolloni, G., Erdös, L., & Schröder, D. J. (2022). Rank-uniform local
law for Wigner matrices. Forum of Mathematics, Sigma. Cambridge University
Press. https://doi.org/10.1017/fms.2022.86
chicago: Cipolloni, Giorgio, László Erdös, and Dominik J Schröder. “Rank-Uniform
Local Law for Wigner Matrices.” Forum of Mathematics, Sigma. Cambridge
University Press, 2022. https://doi.org/10.1017/fms.2022.86.
ieee: G. Cipolloni, L. Erdös, and D. J. Schröder, “Rank-uniform local law for Wigner
matrices,” Forum of Mathematics, Sigma, vol. 10. Cambridge University Press,
2022.
ista: Cipolloni G, Erdös L, Schröder DJ. 2022. Rank-uniform local law for Wigner
matrices. Forum of Mathematics, Sigma. 10, e96.
mla: Cipolloni, Giorgio, et al. “Rank-Uniform Local Law for Wigner Matrices.” Forum
of Mathematics, Sigma, vol. 10, e96, Cambridge University Press, 2022, doi:10.1017/fms.2022.86.
short: G. Cipolloni, L. Erdös, D.J. Schröder, Forum of Mathematics, Sigma 10 (2022).
corr_author: '1'
date_created: 2023-01-12T12:07:30Z
date_published: 2022-10-27T00:00:00Z
date_updated: 2025-04-14T07:57:18Z
day: '27'
ddc:
- '510'
department:
- _id: LaEr
doi: 10.1017/fms.2022.86
ec_funded: 1
external_id:
isi:
- '000873719200001'
file:
- access_level: open_access
checksum: 94a049aeb1eea5497aa097712a73c400
content_type: application/pdf
creator: dernst
date_created: 2023-01-24T10:02:40Z
date_updated: 2023-01-24T10:02:40Z
file_id: '12356'
file_name: 2022_ForumMath_Cipolloni.pdf
file_size: 817089
relation: main_file
success: 1
file_date_updated: 2023-01-24T10:02:40Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
keyword:
- Computational Mathematics
- Discrete Mathematics and Combinatorics
- Geometry and Topology
- Mathematical Physics
- Statistics and Probability
- Algebra and Number Theory
- Theoretical Computer Science
- Analysis
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
call_identifier: H2020
grant_number: '101020331'
name: Random matrices beyond Wigner-Dyson-Mehta
publication: Forum of Mathematics, Sigma
publication_identifier:
issn:
- 2050-5094
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Rank-uniform local law for Wigner matrices
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2022'
...
---
_id: '12149'
abstract:
- lang: eng
text: Editorial on the Research Topic
acknowledgement: This work was supported by a DFG grant ZA990/1 to DZ. This work was
supported by the MSCA EU proposal 841301 - DREAM, European Commission; Horizon 2020
- Research and Innovation Framework Programme to JFRV.
article_number: '1028154'
article_processing_charge: No
article_type: letter_note
author:
- first_name: Giuditta
full_name: Gambino, Giuditta
last_name: Gambino
- first_name: Rebecca
full_name: Bhik-Ghanie, Rebecca
last_name: Bhik-Ghanie
- first_name: Giuseppe
full_name: Giglia, Giuseppe
last_name: Giglia
- first_name: M. Victoria
full_name: Puig, M. Victoria
last_name: Puig
- first_name: Juan F
full_name: Ramirez Villegas, Juan F
id: 44B06F76-F248-11E8-B48F-1D18A9856A87
last_name: Ramirez Villegas
- first_name: Daniel
full_name: Zaldivar, Daniel
last_name: Zaldivar
citation:
ama: 'Gambino G, Bhik-Ghanie R, Giglia G, Puig MV, Ramirez Villegas JF, Zaldivar
D. Editorial: Neuromodulatory ascending systems: Their influence at the microscopic
and macroscopic levels. Frontiers in Neural Circuits. 2022;16. doi:10.3389/fncir.2022.1028154'
apa: 'Gambino, G., Bhik-Ghanie, R., Giglia, G., Puig, M. V., Ramirez Villegas, J.
F., & Zaldivar, D. (2022). Editorial: Neuromodulatory ascending systems: Their
influence at the microscopic and macroscopic levels. Frontiers in Neural Circuits.
Frontiers Media. https://doi.org/10.3389/fncir.2022.1028154'
chicago: 'Gambino, Giuditta, Rebecca Bhik-Ghanie, Giuseppe Giglia, M. Victoria Puig,
Juan F Ramirez Villegas, and Daniel Zaldivar. “Editorial: Neuromodulatory Ascending
Systems: Their Influence at the Microscopic and Macroscopic Levels.” Frontiers
in Neural Circuits. Frontiers Media, 2022. https://doi.org/10.3389/fncir.2022.1028154.'
ieee: 'G. Gambino, R. Bhik-Ghanie, G. Giglia, M. V. Puig, J. F. Ramirez Villegas,
and D. Zaldivar, “Editorial: Neuromodulatory ascending systems: Their influence
at the microscopic and macroscopic levels,” Frontiers in Neural Circuits,
vol. 16. Frontiers Media, 2022.'
ista: 'Gambino G, Bhik-Ghanie R, Giglia G, Puig MV, Ramirez Villegas JF, Zaldivar
D. 2022. Editorial: Neuromodulatory ascending systems: Their influence at the
microscopic and macroscopic levels. Frontiers in Neural Circuits. 16, 1028154.'
mla: 'Gambino, Giuditta, et al. “Editorial: Neuromodulatory Ascending Systems: Their
Influence at the Microscopic and Macroscopic Levels.” Frontiers in Neural Circuits,
vol. 16, 1028154, Frontiers Media, 2022, doi:10.3389/fncir.2022.1028154.'
short: G. Gambino, R. Bhik-Ghanie, G. Giglia, M.V. Puig, J.F. Ramirez Villegas,
D. Zaldivar, Frontiers in Neural Circuits 16 (2022).
date_created: 2023-01-12T12:07:39Z
date_published: 2022-10-26T00:00:00Z
date_updated: 2025-06-12T06:19:09Z
day: '26'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.3389/fncir.2022.1028154
ec_funded: 1
external_id:
isi:
- '000886671400001'
pmid:
- '36405671'
file:
- access_level: open_access
checksum: 457aa00e1800847abb340853058531de
content_type: application/pdf
creator: dernst
date_created: 2023-01-24T10:10:43Z
date_updated: 2023-01-24T10:10:43Z
file_id: '12357'
file_name: 2022_FrontiersNeuralCircuits_Gambino.pdf
file_size: 110031
relation: main_file
success: 1
file_date_updated: 2023-01-24T10:10:43Z
has_accepted_license: '1'
intvolume: ' 16'
isi: 1
keyword:
- Cellular and Molecular Neuroscience
- Cognitive Neuroscience
- Sensory Systems
- Neuroscience (miscellaneous)
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 26BAE2E4-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '841301'
name: 'The Brainstem-Hippocampus Network Uncovered: Dynamics, Reactivation and Memory
Consolidation'
publication: Frontiers in Neural Circuits
publication_identifier:
issn:
- 1662-5110
publication_status: published
publisher: Frontiers Media
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Editorial: Neuromodulatory ascending systems: Their influence at the microscopic
and macroscopic levels'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2022'
...
---
_id: '12150'
abstract:
- lang: eng
text: Methods inspired from machine learning have recently attracted great interest
in the computational study of quantum many-particle systems. So far, however,
it has proven challenging to deal with microscopic models in which the total number
of particles is not conserved. To address this issue, we propose a variant of
neural network states, which we term neural coherent states. Taking the Fröhlich
impurity model as a case study, we show that neural coherent states can learn
the ground state of nonadditive systems very well. In particular, we recover exact
diagonalization in all regimes tested and observe substantial improvement over
the standard coherent state estimates in the most challenging intermediate-coupling
regime. Our approach is generic and does not assume specific details of the system,
suggesting wide applications.
acknowledgement: 'We acknowledge fruitful discussions with G. Bighin, G. Fabiani,
A. Ghazaryan, C. Lampert, and A. Volosniev at various stages of this work. W.R.
acknowledges support through a DOC Fellowship of the Austrian Academy of Sciences
and has received funding from the EU Horizon 2020 programme under the Marie Skłodowska-Curie
Grant Agreement No. 665385. M.L. and J.H.M. acknowledge support by the European
Research Council (ERC) Starting Grant No. 801770 (ANGULON) and Synergy Grant No.
856538 (3D-MAGiC), respectively. This work is part of the Shell-NWO/FOMinitiative
“Computational sciences for energy research” of Shell and Chemical Sciences, Earth
and Life Sciences, Physical Sciences, FOM and STW. '
article_number: '155127'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Wojciech
full_name: Rzadkowski, Wojciech
id: 48C55298-F248-11E8-B48F-1D18A9856A87
last_name: Rzadkowski
orcid: 0000-0002-1106-4419
- first_name: Mikhail
full_name: Lemeshko, Mikhail
id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
last_name: Lemeshko
orcid: 0000-0002-6990-7802
- first_name: Johan H.
full_name: Mentink, Johan H.
last_name: Mentink
citation:
ama: Rzadkowski W, Lemeshko M, Mentink JH. Artificial neural network states for
nonadditive systems. Physical Review B. 2022;106(15). doi:10.1103/physrevb.106.155127
apa: Rzadkowski, W., Lemeshko, M., & Mentink, J. H. (2022). Artificial neural
network states for nonadditive systems. Physical Review B. American Physical
Society. https://doi.org/10.1103/physrevb.106.155127
chicago: Rzadkowski, Wojciech, Mikhail Lemeshko, and Johan H. Mentink. “Artificial
Neural Network States for Nonadditive Systems.” Physical Review B. American
Physical Society, 2022. https://doi.org/10.1103/physrevb.106.155127.
ieee: W. Rzadkowski, M. Lemeshko, and J. H. Mentink, “Artificial neural network
states for nonadditive systems,” Physical Review B, vol. 106, no. 15. American
Physical Society, 2022.
ista: Rzadkowski W, Lemeshko M, Mentink JH. 2022. Artificial neural network states
for nonadditive systems. Physical Review B. 106(15), 155127.
mla: Rzadkowski, Wojciech, et al. “Artificial Neural Network States for Nonadditive
Systems.” Physical Review B, vol. 106, no. 15, 155127, American Physical
Society, 2022, doi:10.1103/physrevb.106.155127.
short: W. Rzadkowski, M. Lemeshko, J.H. Mentink, Physical Review B 106 (2022).
date_created: 2023-01-12T12:07:49Z
date_published: 2022-10-15T00:00:00Z
date_updated: 2025-03-31T16:01:11Z
day: '15'
department:
- _id: MiLe
doi: 10.1103/physrevb.106.155127
ec_funded: 1
external_id:
arxiv:
- '2105.15193'
isi:
- '000875189100005'
intvolume: ' 106'
isi: 1
issue: '15'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.48550/arXiv.2105.15193'
month: '10'
oa: 1
oa_version: Preprint
project:
- _id: 05A235A0-7A3F-11EA-A408-12923DDC885E
grant_number: '25681'
name: Analytic and machine learning approaches to composite quantum impurities
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 2688CF98-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '801770'
name: 'Angulon: physics and applications of a new quasiparticle'
publication: Physical Review B
publication_identifier:
eissn:
- 2469-9969
issn:
- 2469-9950
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Artificial neural network states for nonadditive systems
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 106
year: '2022'
...
---
_id: '12151'
abstract:
- lang: eng
text: The k-sample G(k,W) from a graphon W:[0,1]2→[0,1] is the random graph on {1,…,k},
where we sample x1,…,xk∈[0,1] uniformly at random and make each pair {i,j}⊆{1,…,k}
an edge with probability W(xi,xj), with all these choices being mutually independent.
Let the random variable Xk(W) be the number of edges in G(k,W). Vera T. Sós asked
in 2012 whether two graphons U, W are necessarily weakly isomorphic if the random
variables Xk(U) and Xk(W) have the same distribution for every integer k≥2. This
question when one of the graphons W is a constant function was answered positively
by Endre Csóka and independently by Jacob Fox, Tomasz Łuczak and Vera T. Sós.
Here we investigate the question when W is a 2-step graphon and prove that the
answer is positive for a 3-dimensional family of such graphons. We also present
some related results.
acknowledgement: "Supported by Austrian Science Fund (FWF) Grant I3747. Supported
by ERC Advanced Grant 101020255 and Leverhulme Research Project Grant RPG-2018-424.\r\nAn
extended abstract of this paper appeared in the Proceedings of the European Conference\r\non
Combinatorics, Graph Theory and Applications (EuroComb 2021), CRM Research Perspectives,
Springer."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Oliver
full_name: Cooley, Oliver
id: 43f4ddd0-a46b-11ec-8df6-ef3703bd721d
last_name: Cooley
- first_name: M.
full_name: Kang, M.
last_name: Kang
- first_name: O.
full_name: Pikhurko, O.
last_name: Pikhurko
citation:
ama: Cooley O, Kang M, Pikhurko O. On a question of Vera T. Sós about size forcing
of graphons. Acta Mathematica Hungarica. 2022;168:1-26. doi:10.1007/s10474-022-01265-8
apa: Cooley, O., Kang, M., & Pikhurko, O. (2022). On a question of Vera T. Sós
about size forcing of graphons. Acta Mathematica Hungarica. Springer Nature.
https://doi.org/10.1007/s10474-022-01265-8
chicago: Cooley, Oliver, M. Kang, and O. Pikhurko. “On a Question of Vera T. Sós
about Size Forcing of Graphons.” Acta Mathematica Hungarica. Springer Nature,
2022. https://doi.org/10.1007/s10474-022-01265-8.
ieee: O. Cooley, M. Kang, and O. Pikhurko, “On a question of Vera T. Sós about size
forcing of graphons,” Acta Mathematica Hungarica, vol. 168. Springer Nature,
pp. 1–26, 2022.
ista: Cooley O, Kang M, Pikhurko O. 2022. On a question of Vera T. Sós about size
forcing of graphons. Acta Mathematica Hungarica. 168, 1–26.
mla: Cooley, Oliver, et al. “On a Question of Vera T. Sós about Size Forcing of
Graphons.” Acta Mathematica Hungarica, vol. 168, Springer Nature, 2022,
pp. 1–26, doi:10.1007/s10474-022-01265-8.
short: O. Cooley, M. Kang, O. Pikhurko, Acta Mathematica Hungarica 168 (2022) 1–26.
corr_author: '1'
date_created: 2023-01-12T12:07:59Z
date_published: 2022-11-23T00:00:00Z
date_updated: 2024-10-09T21:03:37Z
day: '23'
department:
- _id: MaKw
doi: 10.1007/s10474-022-01265-8
external_id:
arxiv:
- '2103.09114'
isi:
- '000886839900006'
intvolume: ' 168'
isi: 1
keyword:
- graphon
- k-sample
- graphon forcing
- graph container
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.48550/arXiv.2103.09114'
month: '11'
oa: 1
oa_version: Preprint
page: 1-26
publication: Acta Mathematica Hungarica
publication_identifier:
eissn:
- 1588-2632
issn:
- 0236-5294
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: On a question of Vera T. Sós about size forcing of graphons
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 168
year: '2022'
...
---
_id: '12152'
abstract:
- lang: eng
text: ESCRT-III filaments are composite cytoskeletal polymers that can constrict
and cut cell membranes from the inside of the membrane neck. Membrane-bound ESCRT-III
filaments undergo a series of dramatic composition and geometry changes in the
presence of an ATP-consuming Vps4 enzyme, which causes stepwise changes in the
membrane morphology. We set out to understand the physical mechanisms involved
in translating the changes in ESCRT-III polymer composition into membrane deformation.
We have built a coarse-grained model in which ESCRT-III polymers of different
geometries and mechanical properties are allowed to copolymerise and bind to a
deformable membrane. By modelling ATP-driven stepwise depolymerisation of specific
polymers, we identify mechanical regimes in which changes in filament composition
trigger the associated membrane transition from a flat to a buckled state, and
then to a tubule state that eventually undergoes scission to release a small cargo-loaded
vesicle. We then characterise how the location and kinetics of polymer loss affects
the extent of membrane deformation and the efficiency of membrane neck scission.
Our results identify the near-minimal mechanical conditions for the operation
of shape-shifting composite polymers that sever membrane necks.
acknowledgement: "A.S . received an award from European Research Council (https://erc.europa.eu,
“NEPA\"\r\n802960), and an award from the Royal Society (https://royalsociety.org,
UF160266). L. H.-K.\r\nreceived an award from the Biotechnology and Biological Sciences
Research Council (https://\r\nwww.ukri.org/councils/bbsrc/). E. L. received an award
from the University College London (https://www.ucl.ac.uk/biophysics/news/2022/feb/applications-biop-brian-duff-and-ipls-summerundergraduate-studentships-now-open,
Brian Duff Undergraduate Summer Research Studentship). B.B. and A.S. received an
award from Volkswagen Foundation https://www.volkswagenstiftung.de/en/foundation,
Az 96727), and an award from Medical Research Council (https://www.ukri.org/councils/mrc,
MC_CF1226). A. R. received an\r\naward from the Swiss National Fund for Research
(https://www.snf.ch/en, 31003A_130520,\r\n31003A_149975, and 31003A_173087) and
an award from the European Research Council\r\nConsolidator (https://erc.europa.eu,
311536). The funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript."
article_number: e1010586
article_processing_charge: No
article_type: original
author:
- first_name: Xiuyun
full_name: Jiang, Xiuyun
last_name: Jiang
- first_name: Lena
full_name: Harker-Kirschneck, Lena
last_name: Harker-Kirschneck
- first_name: Christian Eduardo
full_name: Vanhille-Campos, Christian Eduardo
id: 3adeca52-9313-11ed-b1ac-c170b2505714
last_name: Vanhille-Campos
- first_name: Anna-Katharina
full_name: Pfitzner, Anna-Katharina
last_name: Pfitzner
- first_name: Elene
full_name: Lominadze, Elene
last_name: Lominadze
- first_name: Aurélien
full_name: Roux, Aurélien
last_name: Roux
- first_name: Buzz
full_name: Baum, Buzz
last_name: Baum
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
citation:
ama: Jiang X, Harker-Kirschneck L, Vanhille-Campos CE, et al. Modelling membrane
reshaping by staged polymerization of ESCRT-III filaments. PLOS Computational
Biology. 2022;18(10). doi:10.1371/journal.pcbi.1010586
apa: Jiang, X., Harker-Kirschneck, L., Vanhille-Campos, C. E., Pfitzner, A.-K.,
Lominadze, E., Roux, A., … Šarić, A. (2022). Modelling membrane reshaping by staged
polymerization of ESCRT-III filaments. PLOS Computational Biology. Public
Library of Science. https://doi.org/10.1371/journal.pcbi.1010586
chicago: Jiang, Xiuyun, Lena Harker-Kirschneck, Christian Eduardo Vanhille-Campos,
Anna-Katharina Pfitzner, Elene Lominadze, Aurélien Roux, Buzz Baum, and Anđela
Šarić. “Modelling Membrane Reshaping by Staged Polymerization of ESCRT-III Filaments.”
PLOS Computational Biology. Public Library of Science, 2022. https://doi.org/10.1371/journal.pcbi.1010586.
ieee: X. Jiang et al., “Modelling membrane reshaping by staged polymerization
of ESCRT-III filaments,” PLOS Computational Biology, vol. 18, no. 10. Public
Library of Science, 2022.
ista: Jiang X, Harker-Kirschneck L, Vanhille-Campos CE, Pfitzner A-K, Lominadze
E, Roux A, Baum B, Šarić A. 2022. Modelling membrane reshaping by staged polymerization
of ESCRT-III filaments. PLOS Computational Biology. 18(10), e1010586.
mla: Jiang, Xiuyun, et al. “Modelling Membrane Reshaping by Staged Polymerization
of ESCRT-III Filaments.” PLOS Computational Biology, vol. 18, no. 10, e1010586,
Public Library of Science, 2022, doi:10.1371/journal.pcbi.1010586.
short: X. Jiang, L. Harker-Kirschneck, C.E. Vanhille-Campos, A.-K. Pfitzner, E.
Lominadze, A. Roux, B. Baum, A. Šarić, PLOS Computational Biology 18 (2022).
corr_author: '1'
date_created: 2023-01-12T12:08:10Z
date_published: 2022-10-17T00:00:00Z
date_updated: 2025-06-12T06:19:28Z
day: '17'
ddc:
- '570'
department:
- _id: AnSa
doi: 10.1371/journal.pcbi.1010586
ec_funded: 1
external_id:
isi:
- '000924885500005'
pmid:
- '36251703'
file:
- access_level: open_access
checksum: bada6a7865e470cf42bbdfa67dd471d2
content_type: application/pdf
creator: dernst
date_created: 2023-01-24T10:45:01Z
date_updated: 2023-01-24T10:45:01Z
file_id: '12359'
file_name: 2022_PLoSCompBio_Jiang.pdf
file_size: 2641067
relation: main_file
success: 1
file_date_updated: 2023-01-24T10:45:01Z
has_accepted_license: '1'
intvolume: ' 18'
isi: 1
issue: '10'
keyword:
- Computational Theory and Mathematics
- Cellular and Molecular Neuroscience
- Genetics
- Molecular Biology
- Ecology
- Modeling and Simulation
- Ecology
- Evolution
- Behavior and Systematics
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
call_identifier: H2020
grant_number: '802960'
name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
- _id: eba0f67c-77a9-11ec-83b8-cc8501b3e222
grant_number: '96752'
name: 'The evolution of trafficking: from archaea to eukaryotes'
publication: PLOS Computational Biology
publication_identifier:
issn:
- 1553-7358
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
related_material:
link:
- relation: software
url: https://github.com/sharonJXY/3-filament-model
scopus_import: '1'
status: public
title: Modelling membrane reshaping by staged polymerization of ESCRT-III filaments
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 18
year: '2022'
...
---
_id: '12154'
abstract:
- lang: eng
text: We review our theoretical results of the sound propagation in two-dimensional
(2D) systems of ultracold fermionic and bosonic atoms. In the superfluid phase,
characterized by the spontaneous symmetry breaking of the U(1) symmetry, there
is the coexistence of first and second sound. In the case of weakly-interacting
repulsive bosons, we model the recent measurements of the sound velocities of
39K atoms in 2D obtained in the weakly-interacting regime and around the Berezinskii–Kosterlitz–Thouless
(BKT) superfluid-to-normal transition temperature. In particular, we perform a
quite accurate computation of the superfluid density and show that it is reasonably
consistent with the experimental results. For superfluid attractive fermions,
we calculate the first and second sound velocities across the whole BCS-BEC crossover.
In the low-temperature regime, we reproduce the recent measurements of first-sound
speed with 6Li atoms. We also predict that there is mixing between sound modes
only in the finite-temperature BEC regime.
acknowledgement: "This research is partially supported by University of Padova, BIRD
grant “Ultracold atoms\r\nin curved geometries”. KF is supported by Fondazione CARIPARO
with a PhD fellowship. AT is\r\npartially supported by French National Research
Agency ANR Grant Droplets N. ANR-19-CE30-0003-02. LS thanks Herwig Ott and Sandro
Wimberger for their kind invitation to the\r\nInternational Workshop “Quantum Transport
with ultracold atoms” (2022)."
article_number: '2182'
article_processing_charge: Yes
article_type: original
author:
- first_name: Luca
full_name: Salasnich, Luca
last_name: Salasnich
- first_name: Alberto
full_name: Cappellaro, Alberto
id: 9d13b3cb-30a2-11eb-80dc-f772505e8660
last_name: Cappellaro
orcid: 0000-0001-6110-2359
- first_name: Koichiro
full_name: Furutani, Koichiro
last_name: Furutani
- first_name: Andrea
full_name: Tononi, Andrea
last_name: Tononi
- first_name: Giacomo
full_name: Bighin, Giacomo
id: 4CA96FD4-F248-11E8-B48F-1D18A9856A87
last_name: Bighin
orcid: 0000-0001-8823-9777
citation:
ama: Salasnich L, Cappellaro A, Furutani K, Tononi A, Bighin G. First and second
sound in two-dimensional bosonic and fermionic superfluids. Symmetry. 2022;14(10).
doi:10.3390/sym14102182
apa: Salasnich, L., Cappellaro, A., Furutani, K., Tononi, A., & Bighin, G. (2022).
First and second sound in two-dimensional bosonic and fermionic superfluids. Symmetry.
MDPI. https://doi.org/10.3390/sym14102182
chicago: Salasnich, Luca, Alberto Cappellaro, Koichiro Furutani, Andrea Tononi,
and Giacomo Bighin. “First and Second Sound in Two-Dimensional Bosonic and Fermionic
Superfluids.” Symmetry. MDPI, 2022. https://doi.org/10.3390/sym14102182.
ieee: L. Salasnich, A. Cappellaro, K. Furutani, A. Tononi, and G. Bighin, “First
and second sound in two-dimensional bosonic and fermionic superfluids,” Symmetry,
vol. 14, no. 10. MDPI, 2022.
ista: Salasnich L, Cappellaro A, Furutani K, Tononi A, Bighin G. 2022. First and
second sound in two-dimensional bosonic and fermionic superfluids. Symmetry. 14(10),
2182.
mla: Salasnich, Luca, et al. “First and Second Sound in Two-Dimensional Bosonic
and Fermionic Superfluids.” Symmetry, vol. 14, no. 10, 2182, MDPI, 2022,
doi:10.3390/sym14102182.
short: L. Salasnich, A. Cappellaro, K. Furutani, A. Tononi, G. Bighin, Symmetry
14 (2022).
date_created: 2023-01-12T12:08:31Z
date_published: 2022-10-17T00:00:00Z
date_updated: 2023-08-09T10:13:17Z
day: '17'
ddc:
- '530'
department:
- _id: MiLe
doi: 10.3390/sym14102182
external_id:
isi:
- '000875039200001'
file:
- access_level: open_access
checksum: 9b6bd0e484834dd76d7b26e3c5fba8bd
content_type: application/pdf
creator: dernst
date_created: 2023-01-24T10:56:12Z
date_updated: 2023-01-24T10:56:12Z
file_id: '12361'
file_name: 2022_Symmetry_Salsnich.pdf
file_size: 843723
relation: main_file
success: 1
file_date_updated: 2023-01-24T10:56:12Z
has_accepted_license: '1'
intvolume: ' 14'
isi: 1
issue: '10'
keyword:
- Physics and Astronomy (miscellaneous)
- General Mathematics
- Chemistry (miscellaneous)
- Computer Science (miscellaneous)
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
publication: Symmetry
publication_identifier:
issn:
- 2073-8994
publication_status: published
publisher: MDPI
quality_controlled: '1'
scopus_import: '1'
status: public
title: First and second sound in two-dimensional bosonic and fermionic superfluids
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2022'
...
---
_id: '12155'
abstract:
- lang: eng
text: The growing demand of thermal management in various fields such as miniaturized
5G chips has motivated researchers to develop new and high-performance solid-state
refrigeration technologies, typically including multicaloric and thermoelectric
(TE) cooling. Among them, TE cooling has attracted huge attention owing to its
advantages of rapid response, large cooling temperature difference, high stability,
and tunable device size. Bi2Te3-based alloys have long been the only commercialized
TE cooling materials, while novel systems SnSe and Mg3(Bi,Sb)2 have recently been
discovered as potential candidates. However, challenges and problems still require
to be summarized and further resolved for realizing better cooling performance.
In this review, we systematically investigate TE cooling from its internal mechanism,
crucial parameters, to device design and applications. Furthermore, we summarize
the current optimization strategies for existing TE cooling materials, and finally
provide some personal prospects especially the material-planification concept
on future research on establishing better TE cooling.
acknowledgement: We acknowledge support from the National Key Research and Development
Program of China (2018YFA0702100), the National Natural Science Foundation of China
(51571007, 51772012, 52002011 and 52002042), the Basic Science Center Project of
National Natural Science Foundation of China (51788104), Beijing Natural Science
Foundation (JQ18004), 111 Project (B17002), and the National Science Fund for Distinguished
Young Scholars (51925101).
article_processing_charge: No
article_type: original
author:
- first_name: Yongxin
full_name: Qin, Yongxin
last_name: Qin
- first_name: Bingchao
full_name: Qin, Bingchao
last_name: Qin
- first_name: Dongyang
full_name: Wang, Dongyang
last_name: Wang
- first_name: Cheng
full_name: Chang, Cheng
id: 9E331C2E-9F27-11E9-AE48-5033E6697425
last_name: Chang
orcid: 0000-0002-9515-4277
- first_name: Li-Dong
full_name: Zhao, Li-Dong
last_name: Zhao
citation:
ama: 'Qin Y, Qin B, Wang D, Chang C, Zhao L-D. Solid-state cooling: Thermoelectrics.
Energy & Environmental Science. 2022;15(11):4527-4541. doi:10.1039/d2ee02408j'
apa: 'Qin, Y., Qin, B., Wang, D., Chang, C., & Zhao, L.-D. (2022). Solid-state
cooling: Thermoelectrics. Energy & Environmental Science. Royal Society
of Chemistry. https://doi.org/10.1039/d2ee02408j'
chicago: 'Qin, Yongxin, Bingchao Qin, Dongyang Wang, Cheng Chang, and Li-Dong Zhao.
“Solid-State Cooling: Thermoelectrics.” Energy & Environmental Science.
Royal Society of Chemistry, 2022. https://doi.org/10.1039/d2ee02408j.'
ieee: 'Y. Qin, B. Qin, D. Wang, C. Chang, and L.-D. Zhao, “Solid-state cooling:
Thermoelectrics,” Energy & Environmental Science, vol. 15, no. 11.
Royal Society of Chemistry, pp. 4527–4541, 2022.'
ista: 'Qin Y, Qin B, Wang D, Chang C, Zhao L-D. 2022. Solid-state cooling: Thermoelectrics.
Energy & Environmental Science. 15(11), 4527–4541.'
mla: 'Qin, Yongxin, et al. “Solid-State Cooling: Thermoelectrics.” Energy &
Environmental Science, vol. 15, no. 11, Royal Society of Chemistry, 2022,
pp. 4527–41, doi:10.1039/d2ee02408j.'
short: Y. Qin, B. Qin, D. Wang, C. Chang, L.-D. Zhao, Energy & Environmental
Science 15 (2022) 4527–4541.
date_created: 2023-01-12T12:08:41Z
date_published: 2022-11-01T00:00:00Z
date_updated: 2024-01-22T08:13:43Z
day: '01'
department:
- _id: MaIb
doi: 10.1039/d2ee02408j
external_id:
isi:
- '000863642400001'
intvolume: ' 15'
isi: 1
issue: '11'
keyword:
- Pollution
- Nuclear Energy and Engineering
- Renewable Energy
- Sustainability and the Environment
- Environmental Chemistry
language:
- iso: eng
month: '11'
oa_version: None
page: 4527-4541
publication: Energy & Environmental Science
publication_identifier:
eissn:
- 1754-5706
issn:
- 1754-5692
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1039/d3ee90067c
scopus_import: '1'
status: public
title: 'Solid-state cooling: Thermoelectrics'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2022'
...
---
_id: '12156'
abstract:
- lang: eng
text: Models of transcriptional regulation that assume equilibrium binding of transcription
factors have been less successful at predicting gene expression from sequence
in eukaryotes than in bacteria. This could be due to the non-equilibrium nature
of eukaryotic regulation. Unfortunately, the space of possible non-equilibrium
mechanisms is vast and predominantly uninteresting. The key question is therefore
how this space can be navigated efficiently, to focus on mechanisms and models
that are biologically relevant. In this review, we advocate for the normative
role of theory—theory that prescribes rather than just describes—in providing
such a focus. Theory should expand its remit beyond inferring mechanistic models
from data, towards identifying non-equilibrium gene regulatory schemes that may
have been evolutionarily selected, despite their energy consumption, because they
are precise, reliable, fast, or otherwise outperform regulation at equilibrium.
We illustrate our reasoning by toy examples for which we provide simulation code.
acknowledgement: 'This work was supported through the Center for the Physics of Biological
Function (PHYe1734030) and by National Institutes of Health Grants R01GM097275 and
U01DK127429 (TG). GT acknowledges the support of the Austrian Science Fund grant
FWF P28844 and the Human Frontiers Science Program. '
article_number: '100435'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Benjamin
full_name: Zoller, Benjamin
last_name: Zoller
- first_name: Thomas
full_name: Gregor, Thomas
last_name: Gregor
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: '1'
citation:
ama: Zoller B, Gregor T, Tkačik G. Eukaryotic gene regulation at equilibrium, or
non? Current Opinion in Systems Biology. 2022;31(9). doi:10.1016/j.coisb.2022.100435
apa: Zoller, B., Gregor, T., & Tkačik, G. (2022). Eukaryotic gene regulation
at equilibrium, or non? Current Opinion in Systems Biology. Elsevier. https://doi.org/10.1016/j.coisb.2022.100435
chicago: Zoller, Benjamin, Thomas Gregor, and Gašper Tkačik. “Eukaryotic Gene Regulation
at Equilibrium, or Non?” Current Opinion in Systems Biology. Elsevier,
2022. https://doi.org/10.1016/j.coisb.2022.100435.
ieee: B. Zoller, T. Gregor, and G. Tkačik, “Eukaryotic gene regulation at equilibrium,
or non?,” Current Opinion in Systems Biology, vol. 31, no. 9. Elsevier,
2022.
ista: Zoller B, Gregor T, Tkačik G. 2022. Eukaryotic gene regulation at equilibrium,
or non? Current Opinion in Systems Biology. 31(9), 100435.
mla: Zoller, Benjamin, et al. “Eukaryotic Gene Regulation at Equilibrium, or Non?”
Current Opinion in Systems Biology, vol. 31, no. 9, 100435, Elsevier, 2022,
doi:10.1016/j.coisb.2022.100435.
short: B. Zoller, T. Gregor, G. Tkačik, Current Opinion in Systems Biology 31 (2022).
corr_author: '1'
date_created: 2023-01-12T12:08:51Z
date_published: 2022-09-01T00:00:00Z
date_updated: 2025-06-11T13:47:43Z
day: '01'
ddc:
- '570'
department:
- _id: GaTk
doi: 10.1016/j.coisb.2022.100435
external_id:
pmid:
- '36590072'
file:
- access_level: open_access
checksum: 97ef01e0cc60cdc84f45640a0f248fb0
content_type: application/pdf
creator: dernst
date_created: 2023-01-24T12:14:10Z
date_updated: 2023-01-24T12:14:10Z
file_id: '12362'
file_name: 2022_CurrentBiology_Zoller.pdf
file_size: 2214944
relation: main_file
success: 1
file_date_updated: 2023-01-24T12:14:10Z
has_accepted_license: '1'
intvolume: ' 31'
issue: '9'
keyword:
- Applied Mathematics
- Computer Science Applications
- Drug Discovery
- General Biochemistry
- Genetics and Molecular Biology
- Modeling and Simulation
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 254E9036-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P28844-B27
name: Biophysics of information processing in gene regulation
publication: Current Opinion in Systems Biology
publication_identifier:
issn:
- 2452-3100
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Eukaryotic gene regulation at equilibrium, or non?
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 31
year: '2022'
...
---
_id: '12157'
abstract:
- lang: eng
text: 'Polygenic adaptation is thought to be ubiquitous, yet remains poorly understood.
Here, we model this process analytically, in the plausible setting of a highly
polygenic, quantitative trait that experiences a sudden shift in the fitness optimum.
We show how the mean phenotype changes over time, depending on the effect sizes
of loci that contribute to variance in the trait, and characterize the allele
dynamics at these loci. Notably, we describe the two phases of the allele dynamics:
The first is a rapid phase, in which directional selection introduces small frequency
differences between alleles whose effects are aligned with or opposed to the shift,
ultimately leading to small differences in their probability of fixation during
a second, longer phase, governed by stabilizing selection. As we discuss, key
results should hold in more general settings and have important implications for
efforts to identify the genetic basis of adaptation in humans and other species.'
acknowledgement: "We thank Guy Amster, Jeremy Berg, Nick Barton, Yuval Simons and
Molly Przeworski for many helpful discussions, and Jeremy Berg, Graham Coop, Joachim
Hermisson, Guillaume Martin, Will Milligan, Peter Ralph, Yuval Simons, Leo Speidel
and Molly Przeworski for comments on the manuscript.\r\nNational Institutes of Health
GM115889 Laura Katharine Hayward Guy Sella \r\nNational Institutes of Health GM121372
Laura Katharine Hayward"
article_number: '66697'
article_processing_charge: No
article_type: original
author:
- first_name: Laura
full_name: Hayward, Laura
id: fc885ee5-24bf-11eb-ad7b-bcc5104c0c1b
last_name: Hayward
- first_name: Guy
full_name: Sella, Guy
last_name: Sella
citation:
ama: Hayward L, Sella G. Polygenic adaptation after a sudden change in environment.
eLife. 2022;11. doi:10.7554/elife.66697
apa: Hayward, L., & Sella, G. (2022). Polygenic adaptation after a sudden change
in environment. ELife. eLife Sciences Publications. https://doi.org/10.7554/elife.66697
chicago: Hayward, Laura, and Guy Sella. “Polygenic Adaptation after a Sudden Change
in Environment.” ELife. eLife Sciences Publications, 2022. https://doi.org/10.7554/elife.66697.
ieee: L. Hayward and G. Sella, “Polygenic adaptation after a sudden change in environment,”
eLife, vol. 11. eLife Sciences Publications, 2022.
ista: Hayward L, Sella G. 2022. Polygenic adaptation after a sudden change in environment.
eLife. 11, 66697.
mla: Hayward, Laura, and Guy Sella. “Polygenic Adaptation after a Sudden Change
in Environment.” ELife, vol. 11, 66697, eLife Sciences Publications, 2022,
doi:10.7554/elife.66697.
short: L. Hayward, G. Sella, ELife 11 (2022).
corr_author: '1'
date_created: 2023-01-12T12:09:00Z
date_published: 2022-09-26T00:00:00Z
date_updated: 2024-10-09T21:03:38Z
day: '26'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.7554/elife.66697
external_id:
isi:
- '000890735600001'
file:
- access_level: open_access
checksum: 28de155b231ac1c8d4501c98b2fb359a
content_type: application/pdf
creator: dernst
date_created: 2023-01-24T12:21:32Z
date_updated: 2023-01-24T12:21:32Z
file_id: '12363'
file_name: 2022_eLife_Hayward.pdf
file_size: 18935612
relation: main_file
success: 1
file_date_updated: 2023-01-24T12:21:32Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
keyword:
- General Immunology and Microbiology
- General Biochemistry
- Genetics and Molecular Biology
- General Medicine
- General Neuroscience
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
publication: eLife
publication_identifier:
eissn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Polygenic adaptation after a sudden change in environment
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11
year: '2022'
...
---
_id: '12160'
abstract:
- lang: eng
text: We present the Filecoin Hierarchical Consensus framework, which aims to overcome
the throughput challenges of blockchain consensus by horizontally scaling the
network. Unlike traditional sharding designs, based on partitioning the state
of the network, our solution centers on the concept of subnets -which are organized
hierarchically- and can be spawned on-demand to manage new state. Child sub nets
are firewalled from parent subnets, have their own specific policies, and run
a different consensus algorithm, increasing the network capacity and enabling
new applications. Moreover, they benefit from the security of parent subnets by
periodically checkpointing state. In this paper, we introduce the overall system
architecture, our detailed designs for cross-net transaction handling, and the
open questions that we are still exploring.
article_processing_charge: No
author:
- first_name: Alfonso
full_name: De la Rocha, Alfonso
last_name: De la Rocha
- first_name: Eleftherios
full_name: Kokoris Kogias, Eleftherios
id: f5983044-d7ef-11ea-ac6d-fd1430a26d30
last_name: Kokoris Kogias
- first_name: Jorge M.
full_name: Soares, Jorge M.
last_name: Soares
- first_name: Marko
full_name: Vukolic, Marko
last_name: Vukolic
citation:
ama: 'De la Rocha A, Kokoris Kogias E, Soares JM, Vukolic M. Hierarchical consensus:
A horizontal scaling framework for blockchains. In: 42nd International Conference
on Distributed Computing Systems Workshops. Vol 2022. Institute of Electrical
and Electronics Engineers; 2022:45-52. doi:10.1109/icdcsw56584.2022.00018'
apa: 'De la Rocha, A., Kokoris Kogias, E., Soares, J. M., & Vukolic, M. (2022).
Hierarchical consensus: A horizontal scaling framework for blockchains. In 42nd
International Conference on Distributed Computing Systems Workshops (Vol.
2022, pp. 45–52). Bologna, Italy: Institute of Electrical and Electronics Engineers.
https://doi.org/10.1109/icdcsw56584.2022.00018'
chicago: 'De la Rocha, Alfonso, Eleftherios Kokoris Kogias, Jorge M. Soares, and
Marko Vukolic. “Hierarchical Consensus: A Horizontal Scaling Framework for Blockchains.”
In 42nd International Conference on Distributed Computing Systems Workshops,
2022:45–52. Institute of Electrical and Electronics Engineers, 2022. https://doi.org/10.1109/icdcsw56584.2022.00018.'
ieee: 'A. De la Rocha, E. Kokoris Kogias, J. M. Soares, and M. Vukolic, “Hierarchical
consensus: A horizontal scaling framework for blockchains,” in 42nd International
Conference on Distributed Computing Systems Workshops, Bologna, Italy, 2022,
vol. 2022, pp. 45–52.'
ista: 'De la Rocha A, Kokoris Kogias E, Soares JM, Vukolic M. 2022. Hierarchical
consensus: A horizontal scaling framework for blockchains. 42nd International
Conference on Distributed Computing Systems Workshops. ICDCSW: International Conference
on Distributed Computing Systems Workshop vol. 2022, 45–52.'
mla: 'De la Rocha, Alfonso, et al. “Hierarchical Consensus: A Horizontal Scaling
Framework for Blockchains.” 42nd International Conference on Distributed Computing
Systems Workshops, vol. 2022, Institute of Electrical and Electronics Engineers,
2022, pp. 45–52, doi:10.1109/icdcsw56584.2022.00018.'
short: A. De la Rocha, E. Kokoris Kogias, J.M. Soares, M. Vukolic, in:, 42nd International
Conference on Distributed Computing Systems Workshops, Institute of Electrical
and Electronics Engineers, 2022, pp. 45–52.
conference:
end_date: 2022-07-10
location: Bologna, Italy
name: 'ICDCSW: International Conference on Distributed Computing Systems Workshop'
start_date: 2022-07-10
date_created: 2023-01-12T12:09:28Z
date_published: 2022-11-29T00:00:00Z
date_updated: 2023-08-04T09:06:02Z
day: '29'
department:
- _id: ElKo
doi: 10.1109/icdcsw56584.2022.00018
external_id:
isi:
- '000895984800009'
intvolume: ' 2022'
isi: 1
language:
- iso: eng
month: '11'
oa_version: None
page: 45-52
publication: 42nd International Conference on Distributed Computing Systems Workshops
publication_identifier:
eisbn:
- '9781665488792'
eissn:
- 2332-5666
publication_status: published
publisher: Institute of Electrical and Electronics Engineers
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Hierarchical consensus: A horizontal scaling framework for blockchains'
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 2022
year: '2022'
...
---
_id: '12161'
abstract:
- lang: eng
text: 'We introduce LIMES, a new method for learning with non-stationary streaming
data, inspired by the recent success of meta-learning. The main idea is not to
attempt to learn a single classifier that would have to work well across all occurring
data distributions, nor many separate classifiers, but to exploit a hybrid strategy:
we learn a single set of model parameters from which a specific classifier for
any specific data distribution is derived via classifier adaptation. Assuming
a multiclass classification setting with class-prior shift, the adaptation step
can be performed analytically with only the classifier’s bias terms being affected.
Another contribution of our work is an extrapolation step that predicts suitable
adaptation parameters for future time steps based on the previous data. In combination,
we obtain a lightweight procedure for learning from streaming data with varying
class distribution that adds no trainable parameters and almost no memory or computational
overhead compared to training a single model. Experiments on a set of exemplary
tasks using Twitter data show that LIMES achieves higher accuracy than alternative
approaches, especially with respect to the relevant real-world metric of lowest
within-day accuracy.'
article_processing_charge: No
arxiv: 1
author:
- first_name: Paulina
full_name: Tomaszewska, Paulina
last_name: Tomaszewska
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
citation:
ama: 'Tomaszewska P, Lampert C. Lightweight conditional model extrapolation for
streaming data under class-prior shift. In: 26th International Conference on
Pattern Recognition. Vol 2022. Institute of Electrical and Electronics Engineers;
2022:2128-2134. doi:10.1109/icpr56361.2022.9956195'
apa: 'Tomaszewska, P., & Lampert, C. (2022). Lightweight conditional model extrapolation
for streaming data under class-prior shift. In 26th International Conference
on Pattern Recognition (Vol. 2022, pp. 2128–2134). Montreal, Canada: Institute
of Electrical and Electronics Engineers. https://doi.org/10.1109/icpr56361.2022.9956195'
chicago: Tomaszewska, Paulina, and Christoph Lampert. “Lightweight Conditional Model
Extrapolation for Streaming Data under Class-Prior Shift.” In 26th International
Conference on Pattern Recognition, 2022:2128–34. Institute of Electrical and
Electronics Engineers, 2022. https://doi.org/10.1109/icpr56361.2022.9956195.
ieee: P. Tomaszewska and C. Lampert, “Lightweight conditional model extrapolation
for streaming data under class-prior shift,” in 26th International Conference
on Pattern Recognition, Montreal, Canada, 2022, vol. 2022, pp. 2128–2134.
ista: 'Tomaszewska P, Lampert C. 2022. Lightweight conditional model extrapolation
for streaming data under class-prior shift. 26th International Conference on Pattern
Recognition. ICPR: International Conference on Pattern Recognition vol. 2022,
2128–2134.'
mla: Tomaszewska, Paulina, and Christoph Lampert. “Lightweight Conditional Model
Extrapolation for Streaming Data under Class-Prior Shift.” 26th International
Conference on Pattern Recognition, vol. 2022, Institute of Electrical and
Electronics Engineers, 2022, pp. 2128–34, doi:10.1109/icpr56361.2022.9956195.
short: P. Tomaszewska, C. Lampert, in:, 26th International Conference on Pattern
Recognition, Institute of Electrical and Electronics Engineers, 2022, pp. 2128–2134.
conference:
end_date: 2022-08-25
location: Montreal, Canada
name: 'ICPR: International Conference on Pattern Recognition'
start_date: 2022-08-21
corr_author: '1'
date_created: 2023-01-12T12:09:38Z
date_published: 2022-11-29T00:00:00Z
date_updated: 2024-10-09T21:03:41Z
day: '29'
department:
- _id: ChLa
doi: 10.1109/icpr56361.2022.9956195
external_id:
arxiv:
- '2206.05181'
isi:
- '000897707602018'
intvolume: ' 2022'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2206.05181
month: '11'
oa: 1
oa_version: Preprint
page: 2128-2134
publication: 26th International Conference on Pattern Recognition
publication_identifier:
eisbn:
- '9781665490627'
eissn:
- 2831-7475
publication_status: published
publisher: Institute of Electrical and Electronics Engineers
quality_controlled: '1'
scopus_import: '1'
status: public
title: Lightweight conditional model extrapolation for streaming data under class-prior
shift
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 2022
year: '2022'
...
---
_id: '12167'
abstract:
- lang: eng
text: "Payment channels effectively move the transaction load off-chain thereby
successfully addressing the inherent scalability problem most cryptocurrencies
face. A major drawback of payment channels is the need to “top up” funds on-chain
when a channel is depleted. Rebalancing was proposed to alleviate this issue,
where parties with depleting channels move their funds along a cycle to replenish
their channels off-chain. Protocols for rebalancing so far either introduce local
solutions or compromise privacy.\r\nIn this work, we present an opt-in rebalancing
protocol that is both private and globally optimal, meaning our protocol maximizes
the total amount of rebalanced funds. We study rebalancing from the framework
of linear programming. To obtain full privacy guarantees, we leverage multi-party
computation in solving the linear program, which is executed by selected participants
to maintain efficiency. Finally, we efficiently decompose the rebalancing solution
into incentive-compatible cycles which conserve user balances when executed atomically."
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Georgia
full_name: Avarikioti, Georgia
id: c20482a0-3b89-11eb-9862-88cf6404b88c
last_name: Avarikioti
- first_name: Krzysztof Z
full_name: Pietrzak, Krzysztof Z
id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
last_name: Pietrzak
orcid: 0000-0002-9139-1654
- first_name: Iosif
full_name: Salem, Iosif
last_name: Salem
- first_name: Stefan
full_name: Schmid, Stefan
last_name: Schmid
- first_name: Samarth
full_name: Tiwari, Samarth
last_name: Tiwari
- first_name: Michelle X
full_name: Yeo, Michelle X
id: 2D82B818-F248-11E8-B48F-1D18A9856A87
last_name: Yeo
orcid: 0009-0001-3676-4809
citation:
ama: 'Avarikioti G, Pietrzak KZ, Salem I, Schmid S, Tiwari S, Yeo MX. Hide &
Seek: Privacy-preserving rebalancing on payment channel networks. In: Financial
Cryptography and Data Security. Vol 13411. Springer Nature; 2022:358-373.
doi:10.1007/978-3-031-18283-9_17'
apa: 'Avarikioti, G., Pietrzak, K. Z., Salem, I., Schmid, S., Tiwari, S., &
Yeo, M. X. (2022). Hide & Seek: Privacy-preserving rebalancing on payment
channel networks. In Financial Cryptography and Data Security (Vol. 13411,
pp. 358–373). Grenada: Springer Nature. https://doi.org/10.1007/978-3-031-18283-9_17'
chicago: 'Avarikioti, Georgia, Krzysztof Z Pietrzak, Iosif Salem, Stefan Schmid,
Samarth Tiwari, and Michelle X Yeo. “Hide & Seek: Privacy-Preserving Rebalancing
on Payment Channel Networks.” In Financial Cryptography and Data Security,
13411:358–73. Springer Nature, 2022. https://doi.org/10.1007/978-3-031-18283-9_17.'
ieee: 'G. Avarikioti, K. Z. Pietrzak, I. Salem, S. Schmid, S. Tiwari, and M. X.
Yeo, “Hide & Seek: Privacy-preserving rebalancing on payment channel networks,”
in Financial Cryptography and Data Security, Grenada, 2022, vol. 13411,
pp. 358–373.'
ista: 'Avarikioti G, Pietrzak KZ, Salem I, Schmid S, Tiwari S, Yeo MX. 2022. Hide
& Seek: Privacy-preserving rebalancing on payment channel networks. Financial
Cryptography and Data Security. FC: Financial Cryptography and Data Security,
LNCS, vol. 13411, 358–373.'
mla: 'Avarikioti, Georgia, et al. “Hide & Seek: Privacy-Preserving Rebalancing
on Payment Channel Networks.” Financial Cryptography and Data Security,
vol. 13411, Springer Nature, 2022, pp. 358–73, doi:10.1007/978-3-031-18283-9_17.'
short: G. Avarikioti, K.Z. Pietrzak, I. Salem, S. Schmid, S. Tiwari, M.X. Yeo, in:,
Financial Cryptography and Data Security, Springer Nature, 2022, pp. 358–373.
conference:
end_date: 2022-05-06
location: Grenada
name: 'FC: Financial Cryptography and Data Security'
start_date: 2022-05-02
date_created: 2023-01-12T12:10:38Z
date_published: 2022-10-22T00:00:00Z
date_updated: 2025-09-10T09:48:15Z
day: '22'
department:
- _id: KrPi
doi: 10.1007/978-3-031-18283-9_17
external_id:
arxiv:
- '2110.08848'
isi:
- '001423640200017'
intvolume: ' 13411'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2110.08848
month: '10'
oa: 1
oa_version: Preprint
page: 358-373
publication: Financial Cryptography and Data Security
publication_identifier:
eisbn:
- '9783031182839'
eissn:
- 1611-3349
isbn:
- '9783031182822'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Hide & Seek: Privacy-preserving rebalancing on payment channel networks'
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 13411
year: '2022'
...
---
OA_place: repository
OA_type: green
_id: '12168'
abstract:
- lang: eng
text: "Advances in blockchains have influenced the State-Machine-Replication (SMR)
world and many state-of-the-art blockchain-SMR solutions are based on two pillars:
Chaining and Leader-rotation. A predetermined round-robin mechanism used for Leader-rotation,
however, has an undesirable behavior: crashed parties become designated leaders
infinitely often, slowing down overall system performance. In this paper, we provide
a new Leader-Aware SMR framework that, among other desirable properties, formalizes
a Leader-utilization requirement that bounds the number of rounds whose leaders
are faulty in crash-only executions.\r\nWe introduce Carousel, a novel, reputation-based
Leader-rotation solution to achieve Leader-Aware SMR. The challenge in adaptive
Leader-rotation is that it cannot rely on consensus to determine a leader, since
consensus itself needs a leader. Carousel uses the available on-chain information
to determine a leader locally and achieves Liveness despite this difficulty. A
HotStuff implementation fitted with Carousel demonstrates drastic performance
improvements: it increases throughput over 2x in faultless settings and provided
a 20x throughput increase and 5x latency reduction in the presence of faults."
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Shir
full_name: Cohen, Shir
last_name: Cohen
- first_name: Rati
full_name: Gelashvili, Rati
last_name: Gelashvili
- first_name: Eleftherios
full_name: Kokoris Kogias, Eleftherios
id: f5983044-d7ef-11ea-ac6d-fd1430a26d30
last_name: Kokoris Kogias
- first_name: Zekun
full_name: Li, Zekun
last_name: Li
- first_name: Dahlia
full_name: Malkhi, Dahlia
last_name: Malkhi
- first_name: Alberto
full_name: Sonnino, Alberto
last_name: Sonnino
- first_name: Alexander
full_name: Spiegelman, Alexander
last_name: Spiegelman
citation:
ama: 'Cohen S, Gelashvili R, Kokoris Kogias E, et al. Be aware of your leaders.
In: International Conference on Financial Cryptography and Data Security.
Vol 13411. Springer Nature; 2022:279-295. doi:10.1007/978-3-031-18283-9_13'
apa: 'Cohen, S., Gelashvili, R., Kokoris Kogias, E., Li, Z., Malkhi, D., Sonnino,
A., & Spiegelman, A. (2022). Be aware of your leaders. In International
Conference on Financial Cryptography and Data Security (Vol. 13411, pp. 279–295).
Grenada: Springer Nature. https://doi.org/10.1007/978-3-031-18283-9_13'
chicago: Cohen, Shir, Rati Gelashvili, Eleftherios Kokoris Kogias, Zekun Li, Dahlia
Malkhi, Alberto Sonnino, and Alexander Spiegelman. “Be Aware of Your Leaders.”
In International Conference on Financial Cryptography and Data Security,
13411:279–95. Springer Nature, 2022. https://doi.org/10.1007/978-3-031-18283-9_13.
ieee: S. Cohen et al., “Be aware of your leaders,” in International Conference
on Financial Cryptography and Data Security, Grenada, 2022, vol. 13411, pp.
279–295.
ista: 'Cohen S, Gelashvili R, Kokoris Kogias E, Li Z, Malkhi D, Sonnino A, Spiegelman
A. 2022. Be aware of your leaders. International Conference on Financial Cryptography
and Data Security. FC: Financial Cryptography and Data Security, LNCS, vol. 13411,
279–295.'
mla: Cohen, Shir, et al. “Be Aware of Your Leaders.” International Conference
on Financial Cryptography and Data Security, vol. 13411, Springer Nature,
2022, pp. 279–95, doi:10.1007/978-3-031-18283-9_13.
short: S. Cohen, R. Gelashvili, E. Kokoris Kogias, Z. Li, D. Malkhi, A. Sonnino,
A. Spiegelman, in:, International Conference on Financial Cryptography and Data
Security, Springer Nature, 2022, pp. 279–295.
conference:
end_date: 2022-05-06
location: Grenada
name: 'FC: Financial Cryptography and Data Security'
start_date: 2022-05-02
date_created: 2023-01-12T12:10:49Z
date_published: 2022-10-22T00:00:00Z
date_updated: 2025-09-10T09:48:54Z
day: '22'
department:
- _id: ElKo
doi: 10.1007/978-3-031-18283-9_13
external_id:
arxiv:
- '2110.00960'
isi:
- '001423640200013'
intvolume: ' 13411'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2110.00960
month: '10'
oa: 1
oa_version: Preprint
page: 279-295
publication: International Conference on Financial Cryptography and Data Security
publication_identifier:
eisbn:
- '9783031182839'
eissn:
- 1611-3349
isbn:
- '9783031182822'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Be aware of your leaders
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 13411
year: '2022'
...
---
_id: '12170'
abstract:
- lang: eng
text: We present PET, a specialized and highly optimized framework for partial exploration
on probabilistic systems. Over the last decade, several significant advances in
the analysis of Markov decision processes employed partial exploration. In a nutshell,
this idea allows to focus computation on specific parts of the system, guided
by heuristics, while maintaining correctness. In particular, only relevant parts
of the system are constructed on demand, which in turn potentially allows to omit
constructing large parts of the system. Depending on the model, this leads to
dramatic speed-ups, in extreme cases even up to an arbitrary factor. PET unifies
several previous implementations and provides a flexible framework to easily implement
partial exploration for many further problems. Our experimental evaluation shows
significant improvements compared to the previous implementations while vastly
reducing the overhead required to add support for additional properties.
acknowledgement: We thank Pranav Ashok and Maximilian Weininger for their contributions
to spiritual predecessors of PET as well as motivating the initial development of
this tool.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Tobias
full_name: Meggendorfer, Tobias
id: b21b0c15-30a2-11eb-80dc-f13ca25802e1
last_name: Meggendorfer
orcid: 0000-0002-1712-2165
citation:
ama: 'Meggendorfer T. PET – A partial exploration tool for probabilistic verification.
In: 20th International Symposium on Automated Technology for Verification and
Analysis. Vol 13505. Springer Nature; 2022:320-326. doi:10.1007/978-3-031-19992-9_20'
apa: 'Meggendorfer, T. (2022). PET – A partial exploration tool for probabilistic
verification. In 20th International Symposium on Automated Technology for Verification
and Analysis (Vol. 13505, pp. 320–326). Virtual: Springer Nature. https://doi.org/10.1007/978-3-031-19992-9_20'
chicago: Meggendorfer, Tobias. “PET – A Partial Exploration Tool for Probabilistic
Verification.” In 20th International Symposium on Automated Technology for
Verification and Analysis, 13505:320–26. Springer Nature, 2022. https://doi.org/10.1007/978-3-031-19992-9_20.
ieee: T. Meggendorfer, “PET – A partial exploration tool for probabilistic verification,”
in 20th International Symposium on Automated Technology for Verification and
Analysis, Virtual, 2022, vol. 13505, pp. 320–326.
ista: 'Meggendorfer T. 2022. PET – A partial exploration tool for probabilistic
verification. 20th International Symposium on Automated Technology for Verification
and Analysis. ATVA: Automated Technology for Verification and Analysis, LNCS,
vol. 13505, 320–326.'
mla: Meggendorfer, Tobias. “PET – A Partial Exploration Tool for Probabilistic Verification.”
20th International Symposium on Automated Technology for Verification and Analysis,
vol. 13505, Springer Nature, 2022, pp. 320–26, doi:10.1007/978-3-031-19992-9_20.
short: T. Meggendorfer, in:, 20th International Symposium on Automated Technology
for Verification and Analysis, Springer Nature, 2022, pp. 320–326.
conference:
end_date: 2022-10-28
location: Virtual
name: 'ATVA: Automated Technology for Verification and Analysis'
start_date: 2022-10-25
corr_author: '1'
date_created: 2023-01-12T12:11:07Z
date_published: 2022-10-21T00:00:00Z
date_updated: 2025-09-10T09:49:29Z
day: '21'
department:
- _id: KrCh
doi: 10.1007/978-3-031-19992-9_20
external_id:
isi:
- '001456146500020'
intvolume: ' 13505'
isi: 1
language:
- iso: eng
month: '10'
oa_version: None
page: 320-326
publication: 20th International Symposium on Automated Technology for Verification
and Analysis
publication_identifier:
eisbn:
- '9783031199929'
eissn:
- 1611-3349
isbn:
- '9783031199912'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: PET – A partial exploration tool for probabilistic verification
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 13505
year: '2022'
...
---
_id: '12171'
abstract:
- lang: eng
text: 'We propose an algorithmic approach for synthesizing linear hybrid automata
from time-series data. Unlike existing approaches, our approach provides a whole
family of models with the same discrete structure but different dynamics. Each
model in the family is guaranteed to capture the input data up to a precision
error ε, in the following sense: For each time series, the model contains an execution
that is ε-close to the data points. Our construction allows to effectively choose
a model from this family with minimal precision error ε. We demonstrate the algorithm’s
efficiency and its ability to find precise models in two case studies.'
acknowledgement: This work was supported in part by the European Union’s Horizon 2020
research and innovation programme under the Marie Skłodowska-Curie grant agreement
no. 847635, by the ERC-2020-AdG 101020093, by DIREC - Digital Research Centre Denmark,
and by the Villum Investigator Grant S4OS.
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Miriam
full_name: Garcia Soto, Miriam
id: 4B3207F6-F248-11E8-B48F-1D18A9856A87
last_name: Garcia Soto
orcid: 0000-0003-2936-5719
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
- first_name: Christian
full_name: Schilling, Christian
id: 3A2F4DCE-F248-11E8-B48F-1D18A9856A87
last_name: Schilling
orcid: 0000-0003-3658-1065
citation:
ama: 'Garcia Soto M, Henzinger TA, Schilling C. Synthesis of parametric hybrid automata
from time series. In: 20th International Symposium on Automated Technology
for Verification and Analysis. Vol 13505. Springer Nature; 2022:337-353. doi:10.1007/978-3-031-19992-9_22'
apa: 'Garcia Soto, M., Henzinger, T. A., & Schilling, C. (2022). Synthesis of parametric
hybrid automata from time series. In 20th International Symposium on Automated
Technology for Verification and Analysis (Vol. 13505, pp. 337–353). Virtual:
Springer Nature. https://doi.org/10.1007/978-3-031-19992-9_22'
chicago: Garcia Soto, Miriam, Thomas A Henzinger, and Christian Schilling. “Synthesis
of Parametric Hybrid Automata from Time Series.” In 20th International Symposium
on Automated Technology for Verification and Analysis, 13505:337–53. Springer
Nature, 2022. https://doi.org/10.1007/978-3-031-19992-9_22.
ieee: M. Garcia Soto, T. A. Henzinger, and C. Schilling, “Synthesis of parametric
hybrid automata from time series,” in 20th International Symposium on Automated
Technology for Verification and Analysis, Virtual, 2022, vol. 13505, pp. 337–353.
ista: 'Garcia Soto M, Henzinger TA, Schilling C. 2022. Synthesis of parametric hybrid
automata from time series. 20th International Symposium on Automated Technology
for Verification and Analysis. ATVA: Automated Technology for Verification and
Analysis, LNCS, vol. 13505, 337–353.'
mla: Garcia Soto, Miriam, et al. “Synthesis of Parametric Hybrid Automata from Time
Series.” 20th International Symposium on Automated Technology for Verification
and Analysis, vol. 13505, Springer Nature, 2022, pp. 337–53, doi:10.1007/978-3-031-19992-9_22.
short: M. Garcia Soto, T.A. Henzinger, C. Schilling, in:, 20th International Symposium
on Automated Technology for Verification and Analysis, Springer Nature, 2022,
pp. 337–353.
conference:
end_date: 2022-10-28
location: Virtual
name: 'ATVA: Automated Technology for Verification and Analysis'
start_date: 2022-10-25
corr_author: '1'
date_created: 2023-01-12T12:11:16Z
date_published: 2022-10-21T00:00:00Z
date_updated: 2025-09-10T09:50:08Z
day: '21'
department:
- _id: ToHe
doi: 10.1007/978-3-031-19992-9_22
ec_funded: 1
external_id:
arxiv:
- '2208.06383'
isi:
- '001456146500022'
intvolume: ' 13505'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2208.06383
month: '10'
oa: 1
oa_version: Preprint
page: 337-353
project:
- _id: 62781420-2b32-11ec-9570-8d9b63373d4d
call_identifier: H2020
grant_number: '101020093'
name: Vigilant Algorithmic Monitoring of Software
publication: 20th International Symposium on Automated Technology for Verification
and Analysis
publication_identifier:
eisbn:
- '9783031199929'
eissn:
- 1611-3349
isbn:
- '9783031199912'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Synthesis of parametric hybrid automata from time series
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 13505
year: '2022'
...
---
_id: '12173'
abstract:
- lang: eng
text: With increasing urbanization and industrialization, the prevalence of inflammatory
bowel diseases (IBDs) has steadily been rising over the past two decades. IBD
involves flares of gastrointestinal (GI) inflammation accompanied by microbiota
perturbations. However, microbial mechanisms that trigger such flares remain elusive.
Here, we analyzed the association of the emerging pathogen atypical enteropathogenic
E. coli (aEPEC) with IBD disease activity. The presence of diarrheagenic E. coli
was assessed in stool samples from 630 IBD patients and 234 age- and sex-matched
controls without GI symptoms. Microbiota was analyzed with 16S ribosomal RNA gene
amplicon sequencing, and 57 clinical aEPEC isolates were subjected to whole-genome
sequencing and in vitro pathogenicity experiments including biofilm formation,
epithelial barrier function and the ability to induce pro-inflammatory signaling.
The presence of aEPEC correlated with laboratory, clinical and endoscopic disease
activity in ulcerative colitis (UC), as well as microbiota dysbiosis. In vitro,
aEPEC strains induce epithelial p21-activated kinases, disrupt the epithelial
barrier and display potent biofilm formation. The effector proteins espV and espG2
distinguish aEPEC cultured from UC and Crohn’s disease patients, respectively.
EspV-positive aEPEC harbor more virulence factors and have a higher pro-inflammatory
potential, which is counteracted by 5-ASA. aEPEC may tip a fragile immune–microbiota
homeostasis and thereby contribute to flares in UC. aEPEC isolates from UC patients
display properties to disrupt the epithelial barrier and to induce pro-inflammatory
signaling in vitro.
acknowledgement: "We would like to acknowledge Anita Krnjic, Christina Gmainer, Marion
Nehr, Helga Mock, and Sena Ecin for technical support in conducting the experiments.\r\nThis
study was supported by the Austrian Science Fund (P 32302) and the Vienna Science
and Technology Fund (LS18- 053; Austrian Science Fund (FWF)) [P 32302]."
article_number: e2143218
article_processing_charge: No
article_type: original
author:
- first_name: Maximilian
full_name: Baumgartner, Maximilian
last_name: Baumgartner
- first_name: Rebecca
full_name: Zirnbauer, Rebecca
last_name: Zirnbauer
- first_name: Sabine
full_name: Schlager, Sabine
last_name: Schlager
- first_name: Daniel
full_name: Mertens, Daniel
last_name: Mertens
- first_name: Nikolaus
full_name: Gasche, Nikolaus
last_name: Gasche
- first_name: Barbara
full_name: Sladek, Barbara
last_name: Sladek
- first_name: Craig
full_name: Herbold, Craig
last_name: Herbold
- first_name: Olga
full_name: Bochkareva, Olga
last_name: Bochkareva
- first_name: Vera
full_name: Emelianenko, Vera
id: 20152b9d-927a-11ed-8107-be36d740812d
last_name: Emelianenko
- first_name: Harald
full_name: Vogelsang, Harald
last_name: Vogelsang
- first_name: Michaela
full_name: Lang, Michaela
last_name: Lang
- first_name: Anton
full_name: Klotz, Anton
last_name: Klotz
- first_name: Birgit
full_name: Moik, Birgit
last_name: Moik
- first_name: Athanasios
full_name: Makristathis, Athanasios
last_name: Makristathis
- first_name: David
full_name: Berry, David
last_name: Berry
- first_name: Stefanie
full_name: Dabsch, Stefanie
last_name: Dabsch
- first_name: Vineeta
full_name: Khare, Vineeta
last_name: Khare
- first_name: Christoph
full_name: Gasche, Christoph
last_name: Gasche
citation:
ama: Baumgartner M, Zirnbauer R, Schlager S, et al. Atypical enteropathogenic E.
coli are associated with disease activity in ulcerative colitis. Gut Microbes.
2022;14(1). doi:10.1080/19490976.2022.2143218
apa: Baumgartner, M., Zirnbauer, R., Schlager, S., Mertens, D., Gasche, N., Sladek,
B., … Gasche, C. (2022). Atypical enteropathogenic E. coli are associated with
disease activity in ulcerative colitis. Gut Microbes. Taylor & Francis.
https://doi.org/10.1080/19490976.2022.2143218
chicago: Baumgartner, Maximilian, Rebecca Zirnbauer, Sabine Schlager, Daniel Mertens,
Nikolaus Gasche, Barbara Sladek, Craig Herbold, et al. “Atypical Enteropathogenic
E. Coli Are Associated with Disease Activity in Ulcerative Colitis.” Gut Microbes.
Taylor & Francis, 2022. https://doi.org/10.1080/19490976.2022.2143218.
ieee: M. Baumgartner et al., “Atypical enteropathogenic E. coli are associated
with disease activity in ulcerative colitis,” Gut Microbes, vol. 14, no.
1. Taylor & Francis, 2022.
ista: Baumgartner M, Zirnbauer R, Schlager S, Mertens D, Gasche N, Sladek B, Herbold
C, Bochkareva O, Emelianenko V, Vogelsang H, Lang M, Klotz A, Moik B, Makristathis
A, Berry D, Dabsch S, Khare V, Gasche C. 2022. Atypical enteropathogenic E. coli
are associated with disease activity in ulcerative colitis. Gut Microbes. 14(1),
e2143218.
mla: Baumgartner, Maximilian, et al. “Atypical Enteropathogenic E. Coli Are Associated
with Disease Activity in Ulcerative Colitis.” Gut Microbes, vol. 14, no.
1, e2143218, Taylor & Francis, 2022, doi:10.1080/19490976.2022.2143218.
short: M. Baumgartner, R. Zirnbauer, S. Schlager, D. Mertens, N. Gasche, B. Sladek,
C. Herbold, O. Bochkareva, V. Emelianenko, H. Vogelsang, M. Lang, A. Klotz, B.
Moik, A. Makristathis, D. Berry, S. Dabsch, V. Khare, C. Gasche, Gut Microbes
14 (2022).
date_created: 2023-01-12T12:11:36Z
date_published: 2022-11-22T00:00:00Z
date_updated: 2025-06-11T13:39:40Z
day: '22'
ddc:
- '570'
department:
- _id: FyKo
doi: 10.1080/19490976.2022.2143218
external_id:
isi:
- '000889180100001'
pmid:
- '36415023'
file:
- access_level: open_access
checksum: ee7681a17ae27645e9b5c1df61c15429
content_type: application/pdf
creator: dernst
date_created: 2023-01-26T10:56:51Z
date_updated: 2023-01-26T10:56:51Z
file_id: '12400'
file_name: 2022_GutMicrobes_Baumgartner.pdf
file_size: 4075251
relation: main_file
success: 1
file_date_updated: 2023-01-26T10:56:51Z
has_accepted_license: '1'
intvolume: ' 14'
isi: 1
issue: '1'
keyword:
- Infectious Diseases
- Microbiology (medical)
- Gastroenterology
- Microbiology
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Gut Microbes
publication_identifier:
eissn:
- 1949-0984
issn:
- 1949-0976
publication_status: published
publisher: Taylor & Francis
quality_controlled: '1'
scopus_import: '1'
status: public
title: Atypical enteropathogenic E. coli are associated with disease activity in ulcerative
colitis
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2022'
...
---
_id: '12174'
abstract:
- lang: eng
text: "Vacuolar-type H+-ATPase (V-ATPase) is a multimeric complex present in a variety
of cellular membranes that acts as an ATP-dependent proton pump and plays a key
role in pH homeostasis and intracellular signalling pathways. In humans, 22 autosomal
genes encode for a redundant set of subunits allowing the composition of diverse
V-ATPase complexes with specific properties and expression. Sixteen subunits have
been linked to human disease.\r\nHere we describe 26 patients harbouring 20 distinct
pathogenic de novo missense ATP6V1A variants, mainly clustering within the ATP
synthase α/β family-nucleotide-binding domain. At a mean age of 7 years (extremes:
6 weeks, youngest deceased patient to 22 years, oldest patient) clinical pictures
included early lethal encephalopathies with rapidly progressive massive brain
atrophy, severe developmental epileptic encephalopathies and static intellectual
disability with epilepsy. The first clinical manifestation was early hypotonia,
in 70%; 81% developed epilepsy, manifested as developmental epileptic encephalopathies
in 58% of the cohort and with infantile spasms in 62%; 63% of developmental epileptic
encephalopathies failed to achieve any developmental, communicative or motor skills.
Less severe outcomes were observed in 23% of patients who, at a mean age of 10
years and 6 months, exhibited moderate intellectual disability, with independent
walking and variable epilepsy. None of the patients developed communicative language.
Microcephaly (38%) and amelogenesis imperfecta/enamel dysplasia (42%) were additional
clinical features. Brain MRI demonstrated hypomyelination and generalized atrophy
in 68%. Atrophy was progressive in all eight individuals undergoing repeated MRIs.\r\n
\ Fibroblasts of two patients with developmental epileptic
encephalopathies showed decreased LAMP1 expression, Lysotracker staining and increased
organelle pH, consistent with lysosomal impairment and loss of V-ATPase function.
Fibroblasts of two patients with milder disease, exhibited a different phenotype
with increased Lysotracker staining, decreased organelle pH and no significant
modification in LAMP1 expression. Quantification of substrates for lysosomal enzymes
in cellular extracts from four patients revealed discrete accumulation. Transmission
electron microscopy of fibroblasts of four patients with variable severity and
of induced pluripotent stem cell-derived neurons from two patients with developmental
epileptic encephalopathies showed electron-dense inclusions, lipid droplets, osmiophilic
material and lamellated membrane structures resembling phospholipids. Quantitative
assessment in induced pluripotent stem cell-derived neurons identified significantly
smaller lysosomes.\r\nATP6V1A-related encephalopathy represents a new paradigm
among lysosomal disorders. It results from a dysfunctional endo-lysosomal membrane
protein causing altered pH homeostasis. Its pathophysiology implies intracellular
accumulation of substrates whose composition remains unclear, and a combination
of developmental brain abnormalities and neurodegenerative changes established
during prenatal and early postanal development, whose severity is variably determined
by specific pathogenic variants."
acknowledged_ssus:
- _id: EM-Fac
- _id: LifeSc
acknowledgement: "We thank all patients and family members for their participation
in this study. We thank Melanie Pieraks and Eva Reinthaler (Neurolentech, Austria)
for generating the human iPSC lines and\r\nfor performing quality checks. We thank
Vanessa Zheden and Daniel Gütl for their excellent technical support in the specimen
preparation for transmission electron microscopy and Flavia Leite for preparing
the lentiviruses. The support from Electron Microscopy Facility and Molecular Biology
Services at IST Austria is greatly acknowledged. We would like to thank Doctors
Jane Hurst and Richard Scott for their help in retrieving the detailed clinical
information of Patient 17. The research team acknowledges the support of the National
Institute for Health Research, through the Comprehensive Clinical Research Network.
See Supplementary Material for Undiagnosed Disease Network consortium details. Genetic
information on Patient 23 was made available through access to the data and findings
generated by the 100 000 Genomes\r\nProject; www.genomicsengland.co.uk (to K.L.).
\r\nThis work was supported by the EU 7th Framework Programme (FP7) under the project
DESIRE grant N602531 (to R.G.); the Regione Toscana under the Call for Health 2018
(grant\r\nDECODE-EE) (to R.G.); the ‘Brain Project’ by Fondazione Cassa di Risparmio
di Firenze (to R.G.); IRCCS Ospedale Policlinico San Martino 5×1000 and Ricerca
Corrente (to A.F. and F.B.). The European Reference Network (ERN) for rare and complex
epilepsies (EpiCARE) provided financial support for meetings organization. The DDD
study presents independent research commissioned by the Health Innovation Challenge
Fund (grant number HICF-1009-003), a parallel funding partnership between Wellcome
and the Department of Health, and the Wellcome Sanger Institute (grant number WT098051).
The views expressed in this publication\r\nare those of the author(s) and not necessarily
those of Wellcome or the Department of Health. The study has UK Research Ethics
Committee approval (10/H0305/83, granted by the Cambridge South REC, and GEN/284/12
granted by the Republic of Ireland REC). This study makes use of DECIPHER (https://www.deciphergenomics.org),
which is funded by Wellcome. K.K.-S. was supported by the ISTplus fellowship. "
article_processing_charge: No
article_type: original
author:
- first_name: Renzo
full_name: Guerrini, Renzo
last_name: Guerrini
- first_name: Davide
full_name: Mei, Davide
last_name: Mei
- first_name: Margit Katalin
full_name: Szigeti, Margit Katalin
id: 44F4BDC0-F248-11E8-B48F-1D18A9856A87
last_name: Szigeti
orcid: 0000-0001-9500-8758
- first_name: Sara
full_name: Pepe, Sara
last_name: Pepe
- first_name: Mary Kay
full_name: Koenig, Mary Kay
last_name: Koenig
- first_name: Gretchen
full_name: Von Allmen, Gretchen
last_name: Von Allmen
- first_name: Megan T
full_name: Cho, Megan T
last_name: Cho
- first_name: Kimberly
full_name: McDonald, Kimberly
last_name: McDonald
- first_name: Janice
full_name: Baker, Janice
last_name: Baker
- first_name: Vikas
full_name: Bhambhani, Vikas
last_name: Bhambhani
- first_name: Zöe
full_name: Powis, Zöe
last_name: Powis
- first_name: Lance
full_name: Rodan, Lance
last_name: Rodan
- first_name: Rima
full_name: Nabbout, Rima
last_name: Nabbout
- first_name: Giulia
full_name: Barcia, Giulia
last_name: Barcia
- first_name: Jill A
full_name: Rosenfeld, Jill A
last_name: Rosenfeld
- first_name: Carlos A
full_name: Bacino, Carlos A
last_name: Bacino
- first_name: Cyril
full_name: Mignot, Cyril
last_name: Mignot
- first_name: Lillian H
full_name: Power, Lillian H
last_name: Power
- first_name: Catharine J
full_name: Harris, Catharine J
last_name: Harris
- first_name: Dragan
full_name: Marjanovic, Dragan
last_name: Marjanovic
- first_name: Rikke S
full_name: Møller, Rikke S
last_name: Møller
- first_name: Trine B
full_name: Hammer, Trine B
last_name: Hammer
- first_name: Riikka
full_name: Keski Filppula, Riikka
last_name: Keski Filppula
- first_name: Päivi
full_name: Vieira, Päivi
last_name: Vieira
- first_name: Clara
full_name: Hildebrandt, Clara
last_name: Hildebrandt
- first_name: Stephanie
full_name: Sacharow, Stephanie
last_name: Sacharow
- first_name: Luca
full_name: Maragliano, Luca
last_name: Maragliano
- first_name: Fabio
full_name: Benfenati, Fabio
last_name: Benfenati
- first_name: Katherine
full_name: Lachlan, Katherine
last_name: Lachlan
- first_name: Andreas
full_name: Benneche, Andreas
last_name: Benneche
- first_name: Florence
full_name: Petit, Florence
last_name: Petit
- first_name: Jean Madeleine
full_name: de Sainte Agathe, Jean Madeleine
last_name: de Sainte Agathe
- first_name: Barbara
full_name: Hallinan, Barbara
last_name: Hallinan
- first_name: Yue
full_name: Si, Yue
last_name: Si
- first_name: Ingrid M
full_name: Wentzensen, Ingrid M
last_name: Wentzensen
- first_name: Fanggeng
full_name: Zou, Fanggeng
last_name: Zou
- first_name: Vinodh
full_name: Narayanan, Vinodh
last_name: Narayanan
- first_name: Naomichi
full_name: Matsumoto, Naomichi
last_name: Matsumoto
- first_name: Alessandra
full_name: Boncristiano, Alessandra
last_name: Boncristiano
- first_name: Giancarlo
full_name: la Marca, Giancarlo
last_name: la Marca
- first_name: Mitsuhiro
full_name: Kato, Mitsuhiro
last_name: Kato
- first_name: Kristin
full_name: Anderson, Kristin
last_name: Anderson
- first_name: Carmen
full_name: Barba, Carmen
last_name: Barba
- first_name: Luisa
full_name: Sturiale, Luisa
last_name: Sturiale
- first_name: Domenico
full_name: Garozzo, Domenico
last_name: Garozzo
- first_name: Roberto
full_name: Bei, Roberto
last_name: Bei
- first_name: Laura
full_name: Masuelli, Laura
last_name: Masuelli
- first_name: Valerio
full_name: Conti, Valerio
last_name: Conti
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
- first_name: Anna
full_name: Fassio, Anna
last_name: Fassio
citation:
ama: 'Guerrini R, Mei D, Szigeti MK, et al. Phenotypic and genetic spectrum of ATP6V1A
encephalopathy: A disorder of lysosomal homeostasis. Brain. 2022;145(8):2687-2703.
doi:10.1093/brain/awac145'
apa: 'Guerrini, R., Mei, D., Szigeti, M. K., Pepe, S., Koenig, M. K., Von Allmen,
G., … Fassio, A. (2022). Phenotypic and genetic spectrum of ATP6V1A encephalopathy:
A disorder of lysosomal homeostasis. Brain. Oxford University Press. https://doi.org/10.1093/brain/awac145'
chicago: 'Guerrini, Renzo, Davide Mei, Margit Katalin Szigeti, Sara Pepe, Mary Kay
Koenig, Gretchen Von Allmen, Megan T Cho, et al. “Phenotypic and Genetic Spectrum
of ATP6V1A Encephalopathy: A Disorder of Lysosomal Homeostasis.” Brain.
Oxford University Press, 2022. https://doi.org/10.1093/brain/awac145.'
ieee: 'R. Guerrini et al., “Phenotypic and genetic spectrum of ATP6V1A encephalopathy:
A disorder of lysosomal homeostasis,” Brain, vol. 145, no. 8. Oxford University
Press, pp. 2687–2703, 2022.'
ista: 'Guerrini R, Mei D, Szigeti MK, Pepe S, Koenig MK, Von Allmen G, Cho MT, McDonald
K, Baker J, Bhambhani V, Powis Z, Rodan L, Nabbout R, Barcia G, Rosenfeld JA,
Bacino CA, Mignot C, Power LH, Harris CJ, Marjanovic D, Møller RS, Hammer TB,
Keski Filppula R, Vieira P, Hildebrandt C, Sacharow S, Maragliano L, Benfenati
F, Lachlan K, Benneche A, Petit F, de Sainte Agathe JM, Hallinan B, Si Y, Wentzensen
IM, Zou F, Narayanan V, Matsumoto N, Boncristiano A, la Marca G, Kato M, Anderson
K, Barba C, Sturiale L, Garozzo D, Bei R, Masuelli L, Conti V, Novarino G, Fassio
A. 2022. Phenotypic and genetic spectrum of ATP6V1A encephalopathy: A disorder
of lysosomal homeostasis. Brain. 145(8), 2687–2703.'
mla: 'Guerrini, Renzo, et al. “Phenotypic and Genetic Spectrum of ATP6V1A Encephalopathy:
A Disorder of Lysosomal Homeostasis.” Brain, vol. 145, no. 8, Oxford University
Press, 2022, pp. 2687–703, doi:10.1093/brain/awac145.'
short: R. Guerrini, D. Mei, M.K. Szigeti, S. Pepe, M.K. Koenig, G. Von Allmen, M.T.
Cho, K. McDonald, J. Baker, V. Bhambhani, Z. Powis, L. Rodan, R. Nabbout, G. Barcia,
J.A. Rosenfeld, C.A. Bacino, C. Mignot, L.H. Power, C.J. Harris, D. Marjanovic,
R.S. Møller, T.B. Hammer, R. Keski Filppula, P. Vieira, C. Hildebrandt, S. Sacharow,
L. Maragliano, F. Benfenati, K. Lachlan, A. Benneche, F. Petit, J.M. de Sainte
Agathe, B. Hallinan, Y. Si, I.M. Wentzensen, F. Zou, V. Narayanan, N. Matsumoto,
A. Boncristiano, G. la Marca, M. Kato, K. Anderson, C. Barba, L. Sturiale, D.
Garozzo, R. Bei, L. Masuelli, V. Conti, G. Novarino, A. Fassio, Brain 145 (2022)
2687–2703.
date_created: 2023-01-12T12:11:45Z
date_published: 2022-08-01T00:00:00Z
date_updated: 2025-06-11T13:56:33Z
day: '01'
department:
- _id: GaNo
doi: 10.1093/brain/awac145
ec_funded: 1
external_id:
isi:
- '000807770000001'
pmid:
- '35675510'
intvolume: ' 145'
isi: 1
issue: '8'
keyword:
- Neurology (clinical)
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1093/brain/awac145
month: '08'
oa: 1
oa_version: Published Version
page: 2687-2703
pmid: 1
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Brain
publication_identifier:
eissn:
- 1460-2156
issn:
- 0006-8950
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Phenotypic and genetic spectrum of ATP6V1A encephalopathy: A disorder of lysosomal
homeostasis'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 145
year: '2022'
...