---
_id: '10825'
abstract:
- lang: eng
text: In development, lineage segregation is coordinated in time and space. An important
example is the mammalian inner cell mass, in which the primitive endoderm (PrE,
founder of the yolk sac) physically segregates from the epiblast (EPI, founder
of the fetus). While the molecular requirements have been well studied, the physical
mechanisms determining spatial segregation between EPI and PrE remain elusive.
Here, we investigate the mechanical basis of EPI and PrE sorting. We find that
rather than the differences in static cell surface mechanical parameters as in
classical sorting models, it is the differences in surface fluctuations that robustly
ensure physical lineage sorting. These differential surface fluctuations systematically
correlate with differential cellular fluidity, which we propose together constitute
a non-equilibrium sorting mechanism for EPI and PrE lineages. By combining experiments
and modeling, we identify cell surface dynamics as a key factor orchestrating
the correct spatial segregation of the founder embryonic lineages.
acknowledgement: We are grateful to H. Niwa for Dox regulatable PB vector; G. Charras
for EzrinT567D cDNA; K. Jones for tdTomato ESCs, R26-Confetti ESCs, and laboratory
assistance; M. Kinoshita for pPB-CAG-H2B-BFP plasmid; P. Humphreys and D. Clements
for imaging support; G. Chu, P. Attlesey, and staff for animal husbandry; S. Pallett
for laboratory assistance; C. Mulas for critical feedback on the project; T. Boroviak
for single-cell RNA-seq; the EMBL Genomics Core Facility for sequencing; and M.
Merkel for developing and sharing the original version of the 3D Voronoi code. This
work was financially supported by BBSRC ( BB/Moo4023/1 and BB/T007044/1 to K.J.C.
and J.N., Alert16 grant BB/R000042 to E.K.P.), Leverhulme Trust ( RPG-2014-080 to
K.J.C. and J.N.), European Research Council ( 772798 -CellFateTech to K.J.C., 311637
-MorphoCorDiv and 820188 -NanoMechShape to E.K.P., Starting Grant 851288 to E.H.,
and 772426 -MeChemGui to K.F.), the Isaac Newton Trust (to E.K.P.), Medical Research
Council UK (MRC program award MC_UU_00012/5 to E.K.P.), the European Union’s Horizon
2020 research and innovation program under the Marie Sklodowska-Curie grant agreement
no. 641639 ( ITN Biopol , H.D.B. and E.K.P.), the Alexander von Humboldt Foundation
(Alexander von Humboldt Professorship to K.F.), EMBO ALTF 522-2021 (to P.S.), Centre
for Trophoblast Research (Next Generation fellowship to S.A.), and JSPS Overseas
Research Fellowships (to A.Y.). The Wellcome-MRC Cambridge Stem Cell Institute receives
core funding from Wellcome Trust ( 203151/Z/16/Z ) and MRC ( MC_PC_17230 ). For
the purpose of open access, the author has applied a CC BY public copyright licence
to any Author Accepted Manuscript version arising from this submission.
article_processing_charge: No
article_type: original
author:
- first_name: Ayaka
full_name: Yanagida, Ayaka
last_name: Yanagida
- first_name: Elena
full_name: Corujo-Simon, Elena
last_name: Corujo-Simon
- first_name: Christopher K.
full_name: Revell, Christopher K.
last_name: Revell
- first_name: Preeti
full_name: Sahu, Preeti
id: 55BA52EE-A185-11EA-88FD-18AD3DDC885E
last_name: Sahu
- first_name: Giuliano G.
full_name: Stirparo, Giuliano G.
last_name: Stirparo
- first_name: Irene M.
full_name: Aspalter, Irene M.
last_name: Aspalter
- first_name: Alex K.
full_name: Winkel, Alex K.
last_name: Winkel
- first_name: Ruby
full_name: Peters, Ruby
last_name: Peters
- first_name: Henry
full_name: De Belly, Henry
last_name: De Belly
- first_name: Davide A.D.
full_name: Cassani, Davide A.D.
last_name: Cassani
- first_name: Sarra
full_name: Achouri, Sarra
last_name: Achouri
- first_name: Raphael
full_name: Blumenfeld, Raphael
last_name: Blumenfeld
- first_name: Kristian
full_name: Franze, Kristian
last_name: Franze
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Ewa K.
full_name: Paluch, Ewa K.
last_name: Paluch
- first_name: Jennifer
full_name: Nichols, Jennifer
last_name: Nichols
- first_name: Kevin J.
full_name: Chalut, Kevin J.
last_name: Chalut
citation:
ama: Yanagida A, Corujo-Simon E, Revell CK, et al. Cell surface fluctuations regulate
early embryonic lineage sorting. Cell. 2022;185(5):777-793.e20. doi:10.1016/j.cell.2022.01.022
apa: Yanagida, A., Corujo-Simon, E., Revell, C. K., Sahu, P., Stirparo, G. G., Aspalter,
I. M., … Chalut, K. J. (2022). Cell surface fluctuations regulate early embryonic
lineage sorting. Cell. Cell Press. https://doi.org/10.1016/j.cell.2022.01.022
chicago: Yanagida, Ayaka, Elena Corujo-Simon, Christopher K. Revell, Preeti Sahu,
Giuliano G. Stirparo, Irene M. Aspalter, Alex K. Winkel, et al. “Cell Surface
Fluctuations Regulate Early Embryonic Lineage Sorting.” Cell. Cell Press,
2022. https://doi.org/10.1016/j.cell.2022.01.022.
ieee: A. Yanagida et al., “Cell surface fluctuations regulate early embryonic
lineage sorting,” Cell, vol. 185, no. 5. Cell Press, p. 777–793.e20, 2022.
ista: Yanagida A, Corujo-Simon E, Revell CK, Sahu P, Stirparo GG, Aspalter IM, Winkel
AK, Peters R, De Belly H, Cassani DAD, Achouri S, Blumenfeld R, Franze K, Hannezo
EB, Paluch EK, Nichols J, Chalut KJ. 2022. Cell surface fluctuations regulate
early embryonic lineage sorting. Cell. 185(5), 777–793.e20.
mla: Yanagida, Ayaka, et al. “Cell Surface Fluctuations Regulate Early Embryonic
Lineage Sorting.” Cell, vol. 185, no. 5, Cell Press, 2022, p. 777–793.e20,
doi:10.1016/j.cell.2022.01.022.
short: A. Yanagida, E. Corujo-Simon, C.K. Revell, P. Sahu, G.G. Stirparo, I.M. Aspalter,
A.K. Winkel, R. Peters, H. De Belly, D.A.D. Cassani, S. Achouri, R. Blumenfeld,
K. Franze, E.B. Hannezo, E.K. Paluch, J. Nichols, K.J. Chalut, Cell 185 (2022)
777–793.e20.
date_created: 2022-03-06T23:01:52Z
date_published: 2022-02-22T00:00:00Z
date_updated: 2025-07-10T11:50:00Z
day: '22'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1016/j.cell.2022.01.022
ec_funded: 1
external_id:
isi:
- '000796293700007'
pmid:
- '35196500'
file:
- access_level: open_access
checksum: ae305060e8031297771b89dae9e36a29
content_type: application/pdf
creator: dernst
date_created: 2022-03-07T07:55:23Z
date_updated: 2022-03-07T07:55:23Z
file_id: '10831'
file_name: 2022_Cell_Yanagida.pdf
file_size: 8478995
relation: main_file
success: 1
file_date_updated: 2022-03-07T07:55:23Z
has_accepted_license: '1'
intvolume: ' 185'
isi: 1
issue: '5'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '02'
oa: 1
oa_version: Published Version
page: 777-793.e20
pmid: 1
project:
- _id: 05943252-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '851288'
name: Design Principles of Branching Morphogenesis
publication: Cell
publication_identifier:
eissn:
- 1097-4172
issn:
- 0092-8674
publication_status: published
publisher: Cell Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cell surface fluctuations regulate early embryonic lineage sorting
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 185
year: '2022'
...
---
_id: '10841'
abstract:
- lang: eng
text: In eukaryotes, clathrin-coated vesicles (CCVs) facilitate the internalization
of material from the cell surface as well as the movement of cargo in post-Golgi
trafficking pathways. This diversity of functions is partially provided by multiple
monomeric and multimeric clathrin adaptor complexes that provide compartment and
cargo selectivity. The adaptor-protein assembly polypeptide-1 (AP-1) complex operates
as part of the secretory pathway at the trans-Golgi network (TGN), while the AP-2
complex and the TPLATE complex jointly operate at the plasma membrane to execute
clathrin-mediated endocytosis. Key to our further understanding of clathrin-mediated
trafficking in plants will be the comprehensive identification and characterization
of the network of evolutionarily conserved and plant-specific core and accessory
machinery involved in the formation and targeting of CCVs. To facilitate these
studies, we have analyzed the proteome of enriched TGN/early endosome-derived
and endocytic CCVs isolated from dividing and expanding suspension-cultured Arabidopsis
(Arabidopsis thaliana) cells. Tandem mass spectrometry analysis results were validated
by differential chemical labeling experiments to identify proteins co-enriching
with CCVs. Proteins enriched in CCVs included previously characterized CCV components
and cargos such as the vacuolar sorting receptors in addition to conserved and
plant-specific components whose function in clathrin-mediated trafficking has
not been previously defined. Notably, in addition to AP-1 and AP-2, all subunits
of the AP-4 complex, but not AP-3 or AP-5, were found to be in high abundance
in the CCV proteome. The association of AP-4 with suspension-cultured Arabidopsis
CCVs is further supported via additional biochemical data.
acknowledged_ssus:
- _id: EM-Fac
acknowledgement: 'The authors would like to acknowledge the VIB Proteomics Core Facility
(VIB-UGent Center for Medical Biotechnology in Ghent, Belgium) and the Research
Technology Support Facility Proteomics Core (Michigan State University in East Lansing,
Michigan) for sample analysis, as well as the University of Wisconsin Biotechnology
Center Mass Spectrometry Core Facility (Madison, WI) for help with data processing.
Additionally, we are grateful to Sue Weintraub (UT Health San Antonio) and Sydney
Thomas (UW- Madison) for assistance with data analysis. This research was supported
by grants to S.Y.B. from the National Science Foundation (Nos. 1121998 and 1614915)
and a Vilas Associate Award (University of Wisconsin, Madison, Graduate School);
to J.P. from the National Natural Science Foundation of China (Nos. 91754104, 31820103008,
and 31670283); to I.H. from the National Research Foundation of Korea (No. 2019R1A2B5B03099982).
This research was also supported by the Scientific Service Units (SSU) of IST Austria
through resources provided by the Electron microscopy Facility (EMF). A.J. is supported
by funding from the Austrian Science Fund (FWF): I3630B25 to J.F. A.H. is supported
by funding from the National Science Foundation (NSF IOS Nos. 1025837 and 1147032).'
article_processing_charge: No
article_type: original
author:
- first_name: DA
full_name: Dahhan, DA
last_name: Dahhan
- first_name: GD
full_name: Reynolds, GD
last_name: Reynolds
- first_name: JJ
full_name: Cárdenas, JJ
last_name: Cárdenas
- first_name: D
full_name: Eeckhout, D
last_name: Eeckhout
- first_name: Alexander J
full_name: Johnson, Alexander J
id: 46A62C3A-F248-11E8-B48F-1D18A9856A87
last_name: Johnson
orcid: 0000-0002-2739-8843
- first_name: K
full_name: Yperman, K
last_name: Yperman
- first_name: Walter
full_name: Kaufmann, Walter
id: 3F99E422-F248-11E8-B48F-1D18A9856A87
last_name: Kaufmann
orcid: 0000-0001-9735-5315
- first_name: N
full_name: Vang, N
last_name: Vang
- first_name: X
full_name: Yan, X
last_name: Yan
- first_name: I
full_name: Hwang, I
last_name: Hwang
- first_name: A
full_name: Heese, A
last_name: Heese
- first_name: G
full_name: De Jaeger, G
last_name: De Jaeger
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: D
full_name: Van Damme, D
last_name: Van Damme
- first_name: J
full_name: Pan, J
last_name: Pan
- first_name: SY
full_name: Bednarek, SY
last_name: Bednarek
citation:
ama: Dahhan D, Reynolds G, Cárdenas J, et al. Proteomic characterization of isolated
Arabidopsis clathrin-coated vesicles reveals evolutionarily conserved and plant-specific
components. Plant Cell. 2022;34(6):2150-2173. doi:10.1093/plcell/koac071
apa: Dahhan, D., Reynolds, G., Cárdenas, J., Eeckhout, D., Johnson, A. J., Yperman,
K., … Bednarek, S. (2022). Proteomic characterization of isolated Arabidopsis
clathrin-coated vesicles reveals evolutionarily conserved and plant-specific components.
Plant Cell. Oxford University Press. https://doi.org/10.1093/plcell/koac071
chicago: Dahhan, DA, GD Reynolds, JJ Cárdenas, D Eeckhout, Alexander J Johnson,
K Yperman, Walter Kaufmann, et al. “Proteomic Characterization of Isolated Arabidopsis
Clathrin-Coated Vesicles Reveals Evolutionarily Conserved and Plant-Specific Components.”
Plant Cell. Oxford University Press, 2022. https://doi.org/10.1093/plcell/koac071.
ieee: D. Dahhan et al., “Proteomic characterization of isolated Arabidopsis
clathrin-coated vesicles reveals evolutionarily conserved and plant-specific components,”
Plant Cell, vol. 34, no. 6. Oxford University Press, pp. 2150–2173, 2022.
ista: Dahhan D, Reynolds G, Cárdenas J, Eeckhout D, Johnson AJ, Yperman K, Kaufmann
W, Vang N, Yan X, Hwang I, Heese A, De Jaeger G, Friml J, Van Damme D, Pan J,
Bednarek S. 2022. Proteomic characterization of isolated Arabidopsis clathrin-coated
vesicles reveals evolutionarily conserved and plant-specific components. Plant
Cell. 34(6), 2150–2173.
mla: Dahhan, DA, et al. “Proteomic Characterization of Isolated Arabidopsis Clathrin-Coated
Vesicles Reveals Evolutionarily Conserved and Plant-Specific Components.” Plant
Cell, vol. 34, no. 6, Oxford University Press, 2022, pp. 2150–73, doi:10.1093/plcell/koac071.
short: D. Dahhan, G. Reynolds, J. Cárdenas, D. Eeckhout, A.J. Johnson, K. Yperman,
W. Kaufmann, N. Vang, X. Yan, I. Hwang, A. Heese, G. De Jaeger, J. Friml, D. Van
Damme, J. Pan, S. Bednarek, Plant Cell 34 (2022) 2150–2173.
date_created: 2022-03-08T13:47:51Z
date_published: 2022-06-01T00:00:00Z
date_updated: 2025-05-14T11:06:15Z
day: '01'
department:
- _id: JiFr
- _id: EM-Fac
doi: 10.1093/plcell/koac071
external_id:
isi:
- '000767438800001'
pmid:
- '35218346'
intvolume: ' 34'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2021.09.16.460678
month: '06'
oa: 1
oa_version: Preprint
page: 2150-2173
pmid: 1
project:
- _id: 26538374-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03630
name: Molecular mechanisms of endocytic cargo recognition in plants
publication: Plant Cell
publication_identifier:
eissn:
- 1532-298x
issn:
- 1040-4651
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Proteomic characterization of isolated Arabidopsis clathrin-coated vesicles
reveals evolutionarily conserved and plant-specific components
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 34
year: '2022'
...
---
_id: '10842'
abstract:
- lang: eng
text: We determine the unique factorization of some polynomials over a finite local
commutative ring with identity explicitly. This solves and generalizes the main
conjecture of Qian, Shi and Solé in [13]. We also give some applications to enumeration
of certain generalized double circulant self-dual and linear complementary dual
(LCD) codes over some finite rings together with an application in asymptotic
coding theory.
acknowledgement: The authors would like to thank Prof. Dr. Minjia Shi for bringing
[13, Conjecture 3.5] to our attention. We would also like to thank the associate
editor and anonymous reviewers for their valuable comments and suggestions which
improved and clarified the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Seyda
full_name: Köse, Seyda
id: 8ba3170d-dc85-11ea-9058-c4251c96a6eb
last_name: Köse
- first_name: Ferruh
full_name: Özbudak, Ferruh
last_name: Özbudak
citation:
ama: Köse S, Özbudak F. Factorization of some polynomials over finite local commutative
rings and applications to certain self-dual and LCD codes. Cryptography and
Communications. 2022;14(4):933-948. doi:10.1007/s12095-022-00557-8
apa: Köse, S., & Özbudak, F. (2022). Factorization of some polynomials over
finite local commutative rings and applications to certain self-dual and LCD codes.
Cryptography and Communications. Springer Nature. https://doi.org/10.1007/s12095-022-00557-8
chicago: Köse, Seyda, and Ferruh Özbudak. “Factorization of Some Polynomials over
Finite Local Commutative Rings and Applications to Certain Self-Dual and LCD Codes.”
Cryptography and Communications. Springer Nature, 2022. https://doi.org/10.1007/s12095-022-00557-8.
ieee: S. Köse and F. Özbudak, “Factorization of some polynomials over finite local
commutative rings and applications to certain self-dual and LCD codes,” Cryptography
and Communications, vol. 14, no. 4. Springer Nature, pp. 933–948, 2022.
ista: Köse S, Özbudak F. 2022. Factorization of some polynomials over finite local
commutative rings and applications to certain self-dual and LCD codes. Cryptography
and Communications. 14(4), 933–948.
mla: Köse, Seyda, and Ferruh Özbudak. “Factorization of Some Polynomials over Finite
Local Commutative Rings and Applications to Certain Self-Dual and LCD Codes.”
Cryptography and Communications, vol. 14, no. 4, Springer Nature, 2022,
pp. 933–48, doi:10.1007/s12095-022-00557-8.
short: S. Köse, F. Özbudak, Cryptography and Communications 14 (2022) 933–948.
date_created: 2022-03-10T12:16:19Z
date_published: 2022-07-01T00:00:00Z
date_updated: 2023-09-05T15:35:55Z
day: '01'
department:
- _id: GradSch
doi: 10.1007/s12095-022-00557-8
external_id:
isi:
- '000766422000002'
intvolume: ' 14'
isi: 1
issue: '4'
keyword:
- Applied Mathematics
- Computational Theory and Mathematics
- Computer Networks and Communications
language:
- iso: eng
month: '07'
oa_version: None
page: 933-948
publication: Cryptography and Communications
publication_identifier:
eissn:
- 1936-2455
issn:
- 1936-2447
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Factorization of some polynomials over finite local commutative rings and applications
to certain self-dual and LCD codes
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 14
year: '2022'
...
---
_id: '10846'
abstract:
- lang: eng
text: The Golgi apparatus regulates the process of modification and subcellular
localization of macromolecules, including proteins and lipids. Aberrant protein
sorting caused by defects in the Golgi leads to various diseases in mammals. However,
the role of the Golgi apparatus in organismal longevity remained largely unknown.
By employing a quantitative proteomic approach, we demonstrated that MON-2, an
evolutionarily conserved Arf-GEF protein implicated in Golgi-to-endosome trafficking,
promotes longevity via upregulating macroautophagy/autophagy in C. elegans. Our
data using cultured mammalian cells indicate that MON2 translocates from the Golgi
to the endosome under starvation conditions, subsequently increasing autophagic
flux by binding LGG-1/GABARAPL2. Thus, Golgi-to-endosome trafficking appears to
be an evolutionarily conserved process for the upregulation of autophagy, which
contributes to organismal longevity.
acknowledgement: This work is funded by National Research Foundation of Korea (NRF)
grants NRF-2019R1A3B2067745 from the Korean Government (Ministry of Science and
Information and Communications Technology (S-J.V.L.). NRF-2017R1A5A1015366 (S.Y.P,
S-J.V.L). Korea Institute of Science and Technology (KIST) intramural grant (C.L).
article_processing_charge: No
article_type: original
author:
- first_name: Murat
full_name: Artan, Murat
id: C407B586-6052-11E9-B3AE-7006E6697425
last_name: Artan
orcid: 0000-0001-8945-6992
- first_name: Jooyeon
full_name: Sohn, Jooyeon
last_name: Sohn
- first_name: Cheolju
full_name: Lee, Cheolju
last_name: Lee
- first_name: Seung Yeol
full_name: Park, Seung Yeol
last_name: Park
- first_name: Seung Jae V.
full_name: Lee, Seung Jae V.
last_name: Lee
citation:
ama: Artan M, Sohn J, Lee C, Park SY, Lee SJV. MON-2, a Golgi protein, promotes
longevity by upregulating autophagy through mediating inter-organelle communications.
Autophagy. 2022;18(5):1208-1210. doi:10.1080/15548627.2022.2039523
apa: Artan, M., Sohn, J., Lee, C., Park, S. Y., & Lee, S. J. V. (2022). MON-2,
a Golgi protein, promotes longevity by upregulating autophagy through mediating
inter-organelle communications. Autophagy. Taylor & Francis. https://doi.org/10.1080/15548627.2022.2039523
chicago: Artan, Murat, Jooyeon Sohn, Cheolju Lee, Seung Yeol Park, and Seung Jae
V. Lee. “MON-2, a Golgi Protein, Promotes Longevity by Upregulating Autophagy
through Mediating Inter-Organelle Communications.” Autophagy. Taylor &
Francis, 2022. https://doi.org/10.1080/15548627.2022.2039523.
ieee: M. Artan, J. Sohn, C. Lee, S. Y. Park, and S. J. V. Lee, “MON-2, a Golgi protein,
promotes longevity by upregulating autophagy through mediating inter-organelle
communications,” Autophagy, vol. 18, no. 5. Taylor & Francis, pp. 1208–1210,
2022.
ista: Artan M, Sohn J, Lee C, Park SY, Lee SJV. 2022. MON-2, a Golgi protein, promotes
longevity by upregulating autophagy through mediating inter-organelle communications.
Autophagy. 18(5), 1208–1210.
mla: Artan, Murat, et al. “MON-2, a Golgi Protein, Promotes Longevity by Upregulating
Autophagy through Mediating Inter-Organelle Communications.” Autophagy,
vol. 18, no. 5, Taylor & Francis, 2022, pp. 1208–10, doi:10.1080/15548627.2022.2039523.
short: M. Artan, J. Sohn, C. Lee, S.Y. Park, S.J.V. Lee, Autophagy 18 (2022) 1208–1210.
date_created: 2022-03-13T23:01:47Z
date_published: 2022-02-19T00:00:00Z
date_updated: 2023-10-03T10:54:54Z
day: '19'
department:
- _id: MaDe
doi: 10.1080/15548627.2022.2039523
external_id:
isi:
- '000758859600001'
pmid:
- '35188063'
intvolume: ' 18'
isi: 1
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1080/15548627.2022.2039523
month: '02'
oa: 1
oa_version: Published Version
page: 1208-1210
pmid: 1
publication: Autophagy
publication_identifier:
eissn:
- 1554-8635
issn:
- 1554-8627
publication_status: published
publisher: Taylor & Francis
quality_controlled: '1'
scopus_import: '1'
status: public
title: MON-2, a Golgi protein, promotes longevity by upregulating autophagy through
mediating inter-organelle communications
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 18
year: '2022'
...
---
_id: '10863'
abstract:
- lang: eng
text: 'Nonlinear optical responses are commonly used as a probe for studying the
electronic properties of materials. For topological materials, studies thus far
focused on photogalvanic electric currents, which are forbidden in centrosymmetric
materials because they require broken inversion symmetry. In this Letter, we propose
a class of symmetry-allowed responses for inversion-symmetric topological insulators
with two doubly degenerate bands. We consider a specific example of such a response,
the orbital current, and show that the sign of the response reflects the Z2 topological
index, i.e., the orbital current changes sign at the transition between trivial
and topological insulator phases. This is illustrated in two models of topological
insulators: the Bernevig-Hughes-Zhang model and the 1T′ phase of transition metal
dichalcogenides.'
acknowledgement: "We are grateful to Takahiro Morimoto and Zhanybek Alpichshev for
fruitful discussions. MD was supported by Austrian Agency for International Cooperation
in Education and Research (OeAD-GmbH) and by the John Seo Fellowship at MIT. HI
was supported by JSPS KAKENHI Grant Numbers JP19K14649 and JP18H03676, and by UTokyo
Global Activity Support Program for\r\nYoung Researchers."
article_number: L121407
article_processing_charge: No
article_type: letter_note
arxiv: 1
author:
- first_name: Margarita
full_name: Davydova, Margarita
last_name: Davydova
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
- first_name: Hiroaki
full_name: Ishizuka, Hiroaki
last_name: Ishizuka
citation:
ama: Davydova M, Serbyn M, Ishizuka H. Symmetry-allowed nonlinear orbital response
across the topological phase transition in centrosymmetric materials. Physical
Review B. 2022;105. doi:10.1103/PhysRevB.105.L121407
apa: Davydova, M., Serbyn, M., & Ishizuka, H. (2022). Symmetry-allowed nonlinear
orbital response across the topological phase transition in centrosymmetric materials.
Physical Review B. American Physical Society. https://doi.org/10.1103/PhysRevB.105.L121407
chicago: Davydova, Margarita, Maksym Serbyn, and Hiroaki Ishizuka. “Symmetry-Allowed
Nonlinear Orbital Response across the Topological Phase Transition in Centrosymmetric
Materials.” Physical Review B. American Physical Society, 2022. https://doi.org/10.1103/PhysRevB.105.L121407.
ieee: M. Davydova, M. Serbyn, and H. Ishizuka, “Symmetry-allowed nonlinear orbital
response across the topological phase transition in centrosymmetric materials,”
Physical Review B, vol. 105. American Physical Society, 2022.
ista: Davydova M, Serbyn M, Ishizuka H. 2022. Symmetry-allowed nonlinear orbital
response across the topological phase transition in centrosymmetric materials.
Physical Review B. 105, L121407.
mla: Davydova, Margarita, et al. “Symmetry-Allowed Nonlinear Orbital Response across
the Topological Phase Transition in Centrosymmetric Materials.” Physical Review
B, vol. 105, L121407, American Physical Society, 2022, doi:10.1103/PhysRevB.105.L121407.
short: M. Davydova, M. Serbyn, H. Ishizuka, Physical Review B 105 (2022).
date_created: 2022-03-18T10:20:46Z
date_published: 2022-03-17T00:00:00Z
date_updated: 2023-08-03T06:09:56Z
day: '17'
department:
- _id: MaSe
doi: 10.1103/PhysRevB.105.L121407
external_id:
arxiv:
- '2101.08277'
isi:
- '000800752500001'
intvolume: ' 105'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2101.08277
month: '03'
oa: 1
oa_version: Preprint
publication: Physical Review B
publication_identifier:
issn:
- 2469-9969
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Symmetry-allowed nonlinear orbital response across the topological phase transition
in centrosymmetric materials
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 105
year: '2022'
...
---
_id: '10887'
abstract:
- lang: eng
text: "We introduce a new way of representing logarithmically concave functions
on Rd. It allows us to extend the notion of the largest volume ellipsoid contained
in a convex body to the setting of logarithmically concave functions as follows.
For every s>0, we define a class of non-negative functions on Rd derived from
ellipsoids in Rd+1. For any log-concave function f on Rd , and any fixed s>0,
we consider functions belonging to this class, and find the one with the largest
integral under the condition that it is pointwise less than or equal to f, and
we call it the John s-function of f. After establishing existence and uniqueness,
we give a characterization of this function similar to the one given by John in
his fundamental theorem. We find that John s-functions converge to characteristic
functions of ellipsoids as s tends to zero and to Gaussian densities as s tends
to infinity.\r\nAs an application, we prove a quantitative Helly type result:
the integral of the pointwise minimum of any family of log-concave functions is
at least a constant cd multiple of the integral of the pointwise minimum of a
properly chosen subfamily of size 3d+2, where cd depends only on d."
acknowledgement: 'G.I. was supported by the Ministry of Education and Science of the
Russian Federation in the framework of MegaGrant no 075-15-2019-1926. M.N. was supported
by the National Research, Development and Innovation Fund (NRDI) grants K119670
and KKP-133864 as well as the Bolyai Scholarship of the Hungarian Academy of Sciences
and the New National Excellence Programme and the TKP2020-NKA-06 program provided
by the NRDI. '
article_number: '109441'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Grigory
full_name: Ivanov, Grigory
id: 87744F66-5C6F-11EA-AFE0-D16B3DDC885E
last_name: Ivanov
- first_name: Márton
full_name: Naszódi, Márton
last_name: Naszódi
citation:
ama: Ivanov G, Naszódi M. Functional John ellipsoids. Journal of Functional Analysis.
2022;282(11). doi:10.1016/j.jfa.2022.109441
apa: Ivanov, G., & Naszódi, M. (2022). Functional John ellipsoids. Journal
of Functional Analysis. Elsevier. https://doi.org/10.1016/j.jfa.2022.109441
chicago: Ivanov, Grigory, and Márton Naszódi. “Functional John Ellipsoids.” Journal
of Functional Analysis. Elsevier, 2022. https://doi.org/10.1016/j.jfa.2022.109441.
ieee: G. Ivanov and M. Naszódi, “Functional John ellipsoids,” Journal of Functional
Analysis, vol. 282, no. 11. Elsevier, 2022.
ista: Ivanov G, Naszódi M. 2022. Functional John ellipsoids. Journal of Functional
Analysis. 282(11), 109441.
mla: Ivanov, Grigory, and Márton Naszódi. “Functional John Ellipsoids.” Journal
of Functional Analysis, vol. 282, no. 11, 109441, Elsevier, 2022, doi:10.1016/j.jfa.2022.109441.
short: G. Ivanov, M. Naszódi, Journal of Functional Analysis 282 (2022).
corr_author: '1'
date_created: 2022-03-20T23:01:38Z
date_published: 2022-06-01T00:00:00Z
date_updated: 2024-10-09T21:01:51Z
day: '01'
ddc:
- '510'
department:
- _id: UlWa
doi: 10.1016/j.jfa.2022.109441
external_id:
arxiv:
- '2006.09934'
isi:
- '000781371300008'
file:
- access_level: open_access
checksum: 1cf185e264e04c87cb1ce67a00db88ab
content_type: application/pdf
creator: dernst
date_created: 2022-08-02T10:40:48Z
date_updated: 2022-08-02T10:40:48Z
file_id: '11721'
file_name: 2022_JourFunctionalAnalysis_Ivanov.pdf
file_size: 734482
relation: main_file
success: 1
file_date_updated: 2022-08-02T10:40:48Z
has_accepted_license: '1'
intvolume: ' 282'
isi: 1
issue: '11'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
publication: Journal of Functional Analysis
publication_identifier:
eissn:
- 1096-0783
issn:
- 0022-1236
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Functional John ellipsoids
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 282
year: '2022'
...
---
_id: '10888'
abstract:
- lang: eng
text: Despite the growing interest in using chemical genetics in plant research,
small molecule target identification remains a major challenge. The cellular thermal
shift assay coupled with high-resolution mass spectrometry (CETSA MS) that monitors
changes in the thermal stability of proteins caused by their interactions with
small molecules, other proteins, or posttranslational modifications, allows the
discovery of drug targets or the study of protein–metabolite and protein–protein
interactions mainly in mammalian cells. To showcase the applicability of this
method in plants, we applied CETSA MS to intact Arabidopsis thaliana cells and
identified the thermal proteome of the plant-specific glycogen synthase kinase
3 (GSK3) inhibitor, bikinin. A comparison between the thermal and the phosphoproteomes
of bikinin revealed the auxin efflux carrier PIN-FORMED1 (PIN1) as a substrate
of the Arabidopsis GSK3s that negatively regulate the brassinosteroid signaling.
We established that PIN1 phosphorylation by the GSK3s is essential for maintaining
its intracellular polarity that is required for auxin-mediated regulation of vascular
patterning in the leaf, thus revealing cross-talk between brassinosteroid and
auxin signaling.
acknowledgement: "We thank Yanhai Yin for providing the anti-BES1 antibody, Johan
Winne and Brenda Callebaut for synthesizing bikinin, Yuki Kondo and Hiroo Fukuda
for published materials, Tomasz Nodzy\x03nski for useful advice, and Martine De
Cock for help in preparing the manuscript. This\r\nwork was supported by the China
Scholarship Council for predoctoral (Q.L. and X.X.) and postdoctoral (Y.Z.) fellowships;
the Agency for Innovation by Science and Technology for a predoctoral fellowship
(W.D.); the Research Foundation-Flanders, Projects G009018N and G002121N (E.R.);
and the VIB TechWatch Fund (E.R.)."
article_number: e2118220119
article_processing_charge: No
article_type: original
author:
- first_name: Qing
full_name: Lu, Qing
last_name: Lu
- first_name: Yonghong
full_name: Zhang, Yonghong
last_name: Zhang
- first_name: Joakim
full_name: Hellner, Joakim
last_name: Hellner
- first_name: Caterina
full_name: Giannini, Caterina
id: e3fdddd5-f6e0-11ea-865d-ca99ee6367f4
last_name: Giannini
- first_name: Xiangyu
full_name: Xu, Xiangyu
last_name: Xu
- first_name: Jarne
full_name: Pauwels, Jarne
last_name: Pauwels
- first_name: Qian
full_name: Ma, Qian
last_name: Ma
- first_name: Wim
full_name: Dejonghe, Wim
last_name: Dejonghe
- first_name: Huibin
full_name: Han, Huibin
id: 31435098-F248-11E8-B48F-1D18A9856A87
last_name: Han
- first_name: Brigitte
full_name: Van De Cotte, Brigitte
last_name: Van De Cotte
- first_name: Francis
full_name: Impens, Francis
last_name: Impens
- first_name: Kris
full_name: Gevaert, Kris
last_name: Gevaert
- first_name: Ive
full_name: De Smet, Ive
last_name: De Smet
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Daniel Martinez
full_name: Molina, Daniel Martinez
last_name: Molina
- first_name: Eugenia
full_name: Russinova, Eugenia
last_name: Russinova
citation:
ama: Lu Q, Zhang Y, Hellner J, et al. Proteome-wide cellular thermal shift assay
reveals unexpected cross-talk between brassinosteroid and auxin signaling. Proceedings
of the National Academy of Sciences of the United States of America. 2022;119(11).
doi:10.1073/pnas.2118220119
apa: Lu, Q., Zhang, Y., Hellner, J., Giannini, C., Xu, X., Pauwels, J., … Russinova,
E. (2022). Proteome-wide cellular thermal shift assay reveals unexpected cross-talk
between brassinosteroid and auxin signaling. Proceedings of the National Academy
of Sciences of the United States of America. National Academy of Sciences.
https://doi.org/10.1073/pnas.2118220119
chicago: Lu, Qing, Yonghong Zhang, Joakim Hellner, Caterina Giannini, Xiangyu Xu,
Jarne Pauwels, Qian Ma, et al. “Proteome-Wide Cellular Thermal Shift Assay Reveals Unexpected
Cross-Talk between Brassinosteroid and Auxin Signaling.” Proceedings of the
National Academy of Sciences of the United States of America. National Academy
of Sciences, 2022. https://doi.org/10.1073/pnas.2118220119.
ieee: Q. Lu et al., “Proteome-wide cellular thermal shift assay reveals unexpected
cross-talk between brassinosteroid and auxin signaling,” Proceedings of the
National Academy of Sciences of the United States of America, vol. 119, no.
11. National Academy of Sciences, 2022.
ista: Lu Q, Zhang Y, Hellner J, Giannini C, Xu X, Pauwels J, Ma Q, Dejonghe W, Han
H, Van De Cotte B, Impens F, Gevaert K, De Smet I, Friml J, Molina DM, Russinova
E. 2022. Proteome-wide cellular thermal shift assay reveals unexpected cross-talk
between brassinosteroid and auxin signaling. Proceedings of the National Academy
of Sciences of the United States of America. 119(11), e2118220119.
mla: Lu, Qing, et al. “Proteome-Wide Cellular Thermal Shift Assay Reveals Unexpected
Cross-Talk between Brassinosteroid and Auxin Signaling.” Proceedings of the
National Academy of Sciences of the United States of America, vol. 119, no.
11, e2118220119, National Academy of Sciences, 2022, doi:10.1073/pnas.2118220119.
short: Q. Lu, Y. Zhang, J. Hellner, C. Giannini, X. Xu, J. Pauwels, Q. Ma, W. Dejonghe,
H. Han, B. Van De Cotte, F. Impens, K. Gevaert, I. De Smet, J. Friml, D.M. Molina,
E. Russinova, Proceedings of the National Academy of Sciences of the United States
of America 119 (2022).
date_created: 2022-03-20T23:01:39Z
date_published: 2022-03-07T00:00:00Z
date_updated: 2025-05-14T11:01:45Z
day: '07'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1073/pnas.2118220119
external_id:
isi:
- '000771756300008'
pmid:
- '35254915'
file:
- access_level: open_access
checksum: 83e0fea7919570d0b519b41193342571
content_type: application/pdf
creator: dernst
date_created: 2022-03-21T09:19:47Z
date_updated: 2022-03-21T09:19:47Z
file_id: '10910'
file_name: 2022_PNAS_Lu.pdf
file_size: 2169534
relation: main_file
success: 1
file_date_updated: 2022-03-21T09:19:47Z
has_accepted_license: '1'
intvolume: ' 119'
isi: 1
issue: '11'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
publication: Proceedings of the National Academy of Sciences of the United States
of America
publication_identifier:
eissn:
- 1091-6490
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Proteome-wide cellular thermal shift assay reveals unexpected cross-talk between
brassinosteroid and auxin signaling
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 119
year: '2022'
...
---
_id: '10889'
abstract:
- lang: eng
text: Genetically encoded tags have introduced extensive lines of application from
purification of tagged proteins to their visualization at the single molecular,
cellular, histological and whole-body levels. Combined with other rapidly developing
technologies such as clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) system, proteomics, super-resolution microscopy and proximity
labeling, a large variety of genetically encoded tags have been developed in the
last two decades. In this review, I focus on the current status of tag development
for electron microscopic (EM) visualization of proteins with metal particle labeling.
Compared with conventional immunoelectron microscopy using gold particles, tag-mediated
metal particle labeling has several advantages that could potentially improve
the sensitivity, spatial and temporal resolution, and applicability to a wide
range of proteins of interest (POIs). It may enable researchers to detect single
molecules in situ, allowing the quantitative measurement of absolute numbers and
exact localization patterns of POI in the ultrastructural context. Thus, genetically
encoded tags for EM could revolutionize the field as green fluorescence protein
did for light microscopy, although we still have many challenges to overcome before
reaching this goal.
acknowledgement: European Research Council Advanced Grant (694539 to R.S.).
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: Shigemoto R. Electron microscopic visualization of single molecules by tag-mediated
metal particle labeling. Microscopy. 2022;71(Supplement_1):i72-i80. doi:10.1093/jmicro/dfab048
apa: Shigemoto, R. (2022). Electron microscopic visualization of single molecules
by tag-mediated metal particle labeling. Microscopy. Oxford University
Press. https://doi.org/10.1093/jmicro/dfab048
chicago: Shigemoto, Ryuichi. “Electron Microscopic Visualization of Single Molecules
by Tag-Mediated Metal Particle Labeling.” Microscopy. Oxford University
Press, 2022. https://doi.org/10.1093/jmicro/dfab048.
ieee: R. Shigemoto, “Electron microscopic visualization of single molecules by tag-mediated
metal particle labeling,” Microscopy, vol. 71, no. Supplement_1. Oxford
University Press, pp. i72–i80, 2022.
ista: Shigemoto R. 2022. Electron microscopic visualization of single molecules
by tag-mediated metal particle labeling. Microscopy. 71(Supplement_1), i72–i80.
mla: Shigemoto, Ryuichi. “Electron Microscopic Visualization of Single Molecules
by Tag-Mediated Metal Particle Labeling.” Microscopy, vol. 71, no. Supplement_1,
Oxford University Press, 2022, pp. i72–80, doi:10.1093/jmicro/dfab048.
short: R. Shigemoto, Microscopy 71 (2022) i72–i80.
corr_author: '1'
date_created: 2022-03-20T23:01:39Z
date_published: 2022-03-01T00:00:00Z
date_updated: 2025-05-14T11:05:40Z
day: '01'
department:
- _id: RySh
doi: 10.1093/jmicro/dfab048
ec_funded: 1
external_id:
isi:
- '000768384100011'
pmid:
- '35275179'
intvolume: ' 71'
isi: 1
issue: Supplement_1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1093/jmicro/dfab048
month: '03'
oa: 1
oa_version: Published Version
page: i72-i80
pmid: 1
project:
- _id: 25CA28EA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694539'
name: 'In situ analysis of single channel subunit composition in neurons: physiological
implication in synaptic plasticity and behaviour'
publication: Microscopy
publication_identifier:
eissn:
- 2050-5701
issn:
- 2050-5698
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Electron microscopic visualization of single molecules by tag-mediated metal
particle labeling
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 71
year: '2022'
...
---
_id: '10890'
abstract:
- lang: eng
text: Upon the arrival of action potentials at nerve terminals, neurotransmitters
are released from synaptic vesicles (SVs) by exocytosis. CaV2.1, 2.2, and 2.3
are the major subunits of the voltage-gated calcium channel (VGCC) responsible
for increasing intraterminal calcium levels and triggering SV exocytosis in the
central nervous system (CNS) synapses. The two-dimensional analysis of CaV2 distributions
using sodium dodecyl sulfate (SDS)-digested freeze-fracture replica labeling (SDS-FRL)
has revealed their numbers, densities, and nanoscale clustering patterns in individual
presynaptic active zones. The variation in these properties affects the coupling
of VGCCs with calcium sensors on SVs, synaptic efficacy, and temporal precision
of transmission. In this study, we summarize how the morphological parameters
of CaV2 distribution obtained using SDS-FRL differ depending on the different
types of synapses and could correspond to functional properties in synaptic transmission.
acknowledgement: "This work was supported by the European Research Council advanced
grant No. 694539 and the joint German-Austrian DFG and FWF project SYNABS (FWF:
I-4638-B) to RS.\r\nThe authors thank Walter Kaufmann for his critical comments
on the manuscript."
article_number: '846615'
article_processing_charge: No
article_type: original
author:
- first_name: Kohgaku
full_name: Eguchi, Kohgaku
id: 2B7846DC-F248-11E8-B48F-1D18A9856A87
last_name: Eguchi
orcid: 0000-0002-6170-2546
- first_name: Jacqueline-Claire
full_name: Montanaro-Punzengruber, Jacqueline-Claire
id: 3786AB44-F248-11E8-B48F-1D18A9856A87
last_name: Montanaro-Punzengruber
- first_name: Elodie
full_name: Le Monnier, Elodie
id: 3B59276A-F248-11E8-B48F-1D18A9856A87
last_name: Le Monnier
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: Eguchi K, Montanaro-Punzengruber J-C, Le Monnier E, Shigemoto R. The number
and distinct clustering patterns of voltage-gated Calcium channels in nerve terminals.
Frontiers in Neuroanatomy. 2022;16. doi:10.3389/fnana.2022.846615
apa: Eguchi, K., Montanaro-Punzengruber, J.-C., Le Monnier, E., & Shigemoto,
R. (2022). The number and distinct clustering patterns of voltage-gated Calcium
channels in nerve terminals. Frontiers in Neuroanatomy. Frontiers. https://doi.org/10.3389/fnana.2022.846615
chicago: Eguchi, Kohgaku, Jacqueline-Claire Montanaro-Punzengruber, Elodie Le Monnier,
and Ryuichi Shigemoto. “The Number and Distinct Clustering Patterns of Voltage-Gated
Calcium Channels in Nerve Terminals.” Frontiers in Neuroanatomy. Frontiers,
2022. https://doi.org/10.3389/fnana.2022.846615.
ieee: K. Eguchi, J.-C. Montanaro-Punzengruber, E. Le Monnier, and R. Shigemoto,
“The number and distinct clustering patterns of voltage-gated Calcium channels
in nerve terminals,” Frontiers in Neuroanatomy, vol. 16. Frontiers, 2022.
ista: Eguchi K, Montanaro-Punzengruber J-C, Le Monnier E, Shigemoto R. 2022. The
number and distinct clustering patterns of voltage-gated Calcium channels in nerve
terminals. Frontiers in Neuroanatomy. 16, 846615.
mla: Eguchi, Kohgaku, et al. “The Number and Distinct Clustering Patterns of Voltage-Gated
Calcium Channels in Nerve Terminals.” Frontiers in Neuroanatomy, vol. 16,
846615, Frontiers, 2022, doi:10.3389/fnana.2022.846615.
short: K. Eguchi, J.-C. Montanaro-Punzengruber, E. Le Monnier, R. Shigemoto, Frontiers
in Neuroanatomy 16 (2022).
corr_author: '1'
date_created: 2022-03-20T23:01:39Z
date_published: 2022-02-24T00:00:00Z
date_updated: 2025-04-14T07:27:15Z
day: '24'
ddc:
- '570'
department:
- _id: RySh
doi: 10.3389/fnana.2022.846615
ec_funded: 1
external_id:
isi:
- '000766662700001'
pmid:
- '35280978'
file:
- access_level: open_access
checksum: 51ec9b90e7da919e22c01a15489eaacd
content_type: application/pdf
creator: dernst
date_created: 2022-03-21T09:41:19Z
date_updated: 2022-03-21T09:41:19Z
file_id: '10911'
file_name: 2022_FrontiersNeuroanatomy_Eguchi.pdf
file_size: 2416395
relation: main_file
success: 1
file_date_updated: 2022-03-21T09:41:19Z
has_accepted_license: '1'
intvolume: ' 16'
isi: 1
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 25CA28EA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694539'
name: 'In situ analysis of single channel subunit composition in neurons: physiological
implication in synaptic plasticity and behaviour'
- _id: 05970B30-7A3F-11EA-A408-12923DDC885E
grant_number: I04638
name: LGI1 antibody-induced pathophysiology in synapses
publication: Frontiers in Neuroanatomy
publication_identifier:
eissn:
- '16625129'
publication_status: published
publisher: Frontiers
quality_controlled: '1'
scopus_import: '1'
status: public
title: The number and distinct clustering patterns of voltage-gated Calcium channels
in nerve terminals
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 16
year: '2022'
...
---
_id: '10891'
abstract:
- lang: eng
text: We present a formal framework for the online black-box monitoring of software
using monitors with quantitative verdict functions. Quantitative verdict functions
have several advantages. First, quantitative monitors can be approximate, i.e.,
the value of the verdict function does not need to correspond exactly to the value
of the property under observation. Second, quantitative monitors can be quantified
universally, i.e., for every possible observed behavior, the monitor tries to
make the best effort to estimate the value of the property under observation.
Third, quantitative monitors can watch boolean as well as quantitative properties,
such as average response time. Fourth, quantitative monitors can use non-finite-state
resources, such as counters. As a consequence, quantitative monitors can be compared
according to how many resources they use (e.g., the number of counters) and how
precisely they approximate the property under observation. This allows for a rich
spectrum of cost-precision trade-offs in monitoring software.
acknowledgement: The formal framework for quantitative monitoring which is presented
in this invited talk was defined jointly with N. Ege Saraç at LICS 2021. This work
was supported in part by the Wittgenstein Award Z211-N23 of the Austrian Science
Fund.
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
citation:
ama: 'Henzinger TA. Quantitative monitoring of software. In: Software Verification.
Vol 13124. LNCS. Springer Nature; 2022:3-6. doi:10.1007/978-3-030-95561-8_1'
apa: 'Henzinger, T. A. (2022). Quantitative monitoring of software. In Software
Verification (Vol. 13124, pp. 3–6). New Haven, CT, United States: Springer
Nature. https://doi.org/10.1007/978-3-030-95561-8_1'
chicago: Henzinger, Thomas A. “Quantitative Monitoring of Software.” In Software
Verification, 13124:3–6. LNCS. Springer Nature, 2022. https://doi.org/10.1007/978-3-030-95561-8_1.
ieee: T. A. Henzinger, “Quantitative monitoring of software,” in Software Verification,
New Haven, CT, United States, 2022, vol. 13124, pp. 3–6.
ista: 'Henzinger TA. 2022. Quantitative monitoring of software. Software Verification.
NSV: Numerical Software VerificationLNCS vol. 13124, 3–6.'
mla: Henzinger, Thomas A. “Quantitative Monitoring of Software.” Software Verification,
vol. 13124, Springer Nature, 2022, pp. 3–6, doi:10.1007/978-3-030-95561-8_1.
short: T.A. Henzinger, in:, Software Verification, Springer Nature, 2022, pp. 3–6.
conference:
end_date: 2021-10-19
location: New Haven, CT, United States
name: 'NSV: Numerical Software Verification'
start_date: 2021-10-18
corr_author: '1'
date_created: 2022-03-20T23:01:40Z
date_published: 2022-02-22T00:00:00Z
date_updated: 2025-04-15T06:25:58Z
day: '22'
department:
- _id: ToHe
doi: 10.1007/978-3-030-95561-8_1
external_id:
isi:
- '000771713200001'
intvolume: ' 13124'
isi: 1
language:
- iso: eng
month: '02'
oa_version: None
page: 3-6
project:
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: Formal methods for the design and analysis of complex systems
publication: Software Verification
publication_identifier:
eissn:
- 1611-3349
isbn:
- '9783030955601'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
series_title: LNCS
status: public
title: Quantitative monitoring of software
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13124
year: '2022'
...
---
_id: '10918'
abstract:
- lang: eng
text: Cellular metabolism must adapt to changing demands to enable homeostasis.
During immune responses or cancer metastasis, cells leading migration into challenging
environments require an energy boost, but what controls this capacity is unclear.
Here, we study a previously uncharacterized nuclear protein, Atossa (encoded by
CG9005), which supports macrophage invasion into the germband of Drosophila by
controlling cellular metabolism. First, nuclear Atossa increases mRNA levels of
Porthos, a DEAD-box protein, and of two metabolic enzymes, lysine-α-ketoglutarate
reductase (LKR/SDH) and NADPH glyoxylate reductase (GR/HPR), thus enhancing mitochondrial
bioenergetics. Then Porthos supports ribosome assembly and thereby raises the
translational efficiency of a subset of mRNAs, including those affecting mitochondrial
functions, the electron transport chain, and metabolism. Mitochondrial respiration
measurements, metabolomics, and live imaging indicate that Atossa and Porthos
power up OxPhos and energy production to promote the forging of a path into tissues
by leading macrophages. Since many crucial physiological responses require increases
in mitochondrial energy output, this previously undescribed genetic program may
modulate a wide range of cellular behaviors.
acknowledged_ssus:
- _id: Bio
acknowledgement: "We thank the DGRC (NIH grant 2P40OD010949-10A1) for plasmids, the
BDSC (NIH grant P40OD018537) and the VDRC for fly stocks, FlyBase for essential
genomic information, the BDGP in situ database for data (Tomancak et al, 2007),
the IST Austria Bioimaging facility for support, the VBC Core Facilities for RNA
sequencing and analysis, and C. Guet, C. Navarro, C. Desplan, T. Lecuit, I. Miguel-Aliaga,
and Siekhaus group members for comments on the manuscript. The VBCF Metabolomics
Facility is funded by the City of Vienna through the Vienna Business Agency. This
work was supported by the Marie Curie CIG 334077/IRTIM (DES), Austrian Science Fund
(FWF) Lise Meitner Fellowship M2379-B28 (MA and DES), Austrian Science Fund (FWF)
grant ASI_FWF01_P29638S (DES), NIH/NIGMS (R01GM111779-06 (PR), RO1GM135628-01 (PR),
European Research Council (ERC) grant no. 677006 “CMIL” (AB), and Natural Sciences
and Engineering Research Council of Canada\r\n(RGPIN-2019-06766) (TRH). "
article_number: e109049
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Shamsi
full_name: Emtenani, Shamsi
id: 49D32318-F248-11E8-B48F-1D18A9856A87
last_name: Emtenani
orcid: 0000-0001-6981-6938
- first_name: Elliot T
full_name: Martin, Elliot T
last_name: Martin
- first_name: Attila
full_name: György, Attila
id: 3BCEDBE0-F248-11E8-B48F-1D18A9856A87
last_name: György
orcid: 0000-0002-1819-198X
- first_name: Julia
full_name: Bicher, Julia
id: 3CCBB46E-F248-11E8-B48F-1D18A9856A87
last_name: Bicher
- first_name: Jakob-Wendelin
full_name: Genger, Jakob-Wendelin
last_name: Genger
- first_name: Thomas
full_name: Köcher, Thomas
last_name: Köcher
- first_name: Maria
full_name: Akhmanova, Maria
id: 3425EC26-F248-11E8-B48F-1D18A9856A87
last_name: Akhmanova
orcid: 0000-0003-1522-3162
- first_name: Mariana
full_name: Pereira Guarda, Mariana
id: 6de81d9d-e2f2-11eb-945a-af8bc2a60b26
last_name: Pereira Guarda
orcid: 0000-0001-8238-480X
- first_name: Marko
full_name: Roblek, Marko
id: 3047D808-F248-11E8-B48F-1D18A9856A87
last_name: Roblek
orcid: 0000-0001-9588-1389
- first_name: Andreas
full_name: Bergthaler, Andreas
last_name: Bergthaler
- first_name: Thomas R
full_name: Hurd, Thomas R
last_name: Hurd
- first_name: Prashanth
full_name: Rangan, Prashanth
last_name: Rangan
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
citation:
ama: Emtenani S, Martin ET, György A, et al. Macrophage mitochondrial bioenergetics
and tissue invasion are boosted by an Atossa-Porthos axis in Drosophila. The
Embo Journal. 2022;41. doi:10.15252/embj.2021109049
apa: Emtenani, S., Martin, E. T., György, A., Bicher, J., Genger, J.-W., Köcher,
T., … Siekhaus, D. E. (2022). Macrophage mitochondrial bioenergetics and tissue
invasion are boosted by an Atossa-Porthos axis in Drosophila. The Embo Journal.
Embo Press. https://doi.org/10.15252/embj.2021109049
chicago: Emtenani, Shamsi, Elliot T Martin, Attila György, Julia Bicher, Jakob-Wendelin
Genger, Thomas Köcher, Maria Akhmanova, et al. “Macrophage Mitochondrial Bioenergetics
and Tissue Invasion Are Boosted by an Atossa-Porthos Axis in Drosophila.” The
Embo Journal. Embo Press, 2022. https://doi.org/10.15252/embj.2021109049.
ieee: S. Emtenani et al., “Macrophage mitochondrial bioenergetics and tissue
invasion are boosted by an Atossa-Porthos axis in Drosophila,” The Embo Journal,
vol. 41. Embo Press, 2022.
ista: Emtenani S, Martin ET, György A, Bicher J, Genger J-W, Köcher T, Akhmanova
M, Pereira Guarda M, Roblek M, Bergthaler A, Hurd TR, Rangan P, Siekhaus DE. 2022.
Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa-Porthos
axis in Drosophila. The Embo Journal. 41, e109049.
mla: Emtenani, Shamsi, et al. “Macrophage Mitochondrial Bioenergetics and Tissue
Invasion Are Boosted by an Atossa-Porthos Axis in Drosophila.” The Embo Journal,
vol. 41, e109049, Embo Press, 2022, doi:10.15252/embj.2021109049.
short: S. Emtenani, E.T. Martin, A. György, J. Bicher, J.-W. Genger, T. Köcher,
M. Akhmanova, M. Pereira Guarda, M. Roblek, A. Bergthaler, T.R. Hurd, P. Rangan,
D.E. Siekhaus, The Embo Journal 41 (2022).
corr_author: '1'
date_created: 2022-03-24T13:23:09Z
date_published: 2022-03-23T00:00:00Z
date_updated: 2025-06-12T06:20:16Z
day: '23'
ddc:
- '570'
department:
- _id: DaSi
- _id: LoSw
doi: 10.15252/embj.2021109049
ec_funded: 1
external_id:
isi:
- '000771957000001'
pmid:
- '35319107'
file:
- access_level: open_access
checksum: dba48580fe0fefaa4c63078d1d2a35df
content_type: application/pdf
creator: siekhaus
date_created: 2022-03-24T13:22:41Z
date_updated: 2022-03-24T13:22:41Z
file_id: '10919'
file_name: Macrophage mitochondrial bioenergetics and tissue invasion are boosted
by an Atossa-Porthos axis in Drosopila.pdf
file_size: 4344585
relation: main_file
file_date_updated: 2022-03-24T13:22:41Z
has_accepted_license: '1'
intvolume: ' 41'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 2536F660-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '334077'
name: Investigating the role of transporters in invasive migration through junctions
- _id: 264CBBAC-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02379
name: Modeling epithelial tissue mechanics during cell invasion
- _id: 253B6E48-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P29638
name: The role of Drosophila TNF alpha in immune cell invasion
publication: The Embo Journal
publication_identifier:
eissn:
- 1460-2075
publication_status: published
publisher: Embo Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an
Atossa-Porthos axis in Drosophila
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 41
year: '2022'
...
---
_id: '10920'
abstract:
- lang: eng
text: The spin-orbit interaction permits to control the state of a spin qubit via
electric fields. For holes it is particularly strong, allowing for fast all electrical
qubit manipulation, and yet an in-depth understanding of this interaction in hole
systems is missing. Here we investigate, experimentally and theoretically, the
effect of the cubic Rashba spin-orbit interaction on the mixing of the spin states
by studying singlet-triplet oscillations in a planar Ge hole double quantum dot.
Landau-Zener sweeps at different magnetic field directions allow us to disentangle
the effects of the spin-orbit induced spin-flip term from those caused by strongly
site-dependent and anisotropic quantum dot g tensors. Our work, therefore, provides
new insights into the hole spin-orbit interaction, necessary for optimizing future
qubit experiments.
acknowledged_ssus:
- _id: M-Shop
- _id: NanoFab
acknowledgement: "This research was supported by the Scientific Service Units of ISTA
through resources provided by the MIBA Machine Shop and the nanofabrication facility.
This project has received funding from the European Union’s Horizon 2020 research
and innovation program under the Marie\r\nSkłodowska-Curie Grant Agreement No. 844511,
No. 75441, and by the FWF-P 30207, I05060, and M3032-N projects. A. B. acknowledges
support from the EU Horizon-2020 FET project microSPIRE, ID: 766955. P.M. M. and
G. B. acknowledge funding by the Deutsche Forschungsgemeinschaft (DFG—German Research
Foundation) under Project No. 450396347. This work was supported by the Royal Society
(URF\\R1\\191150) and the European Research Council (Grant Agreement No. 948932),
N. A. acknowledges the use of the University of Oxford Advanced Research Computing
(ARC) facility."
article_number: '126803'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Daniel
full_name: Jirovec, Daniel
id: 4C473F58-F248-11E8-B48F-1D18A9856A87
last_name: Jirovec
orcid: 0000-0002-7197-4801
- first_name: Philipp M.
full_name: Mutter, Philipp M.
last_name: Mutter
- first_name: Andrea C
full_name: Hofmann, Andrea C
id: 340F461A-F248-11E8-B48F-1D18A9856A87
last_name: Hofmann
- first_name: Alessandro
full_name: Crippa, Alessandro
id: 1F2B21A2-F6E7-11E9-9B82-F7DBE5697425
last_name: Crippa
orcid: 0000-0002-2968-611X
- first_name: Marek
full_name: Rychetsky, Marek
last_name: Rychetsky
- first_name: David L.
full_name: Craig, David L.
last_name: Craig
- first_name: Josip
full_name: Kukucka, Josip
id: 3F5D8856-F248-11E8-B48F-1D18A9856A87
last_name: Kukucka
- first_name: Frederico
full_name: Martins, Frederico
id: 38F80F9A-1CB8-11EA-BC76-B49B3DDC885E
last_name: Martins
orcid: 0000-0003-2668-2401
- first_name: Andrea
full_name: Ballabio, Andrea
last_name: Ballabio
- first_name: Natalia
full_name: Ares, Natalia
last_name: Ares
- first_name: Daniel
full_name: Chrastina, Daniel
last_name: Chrastina
- first_name: Giovanni
full_name: Isella, Giovanni
last_name: Isella
- first_name: 'Guido '
full_name: 'Burkard, Guido '
last_name: Burkard
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
citation:
ama: Jirovec D, Mutter PM, Hofmann AC, et al. Dynamics of hole singlet-triplet qubits
with large g-factor differences. Physical Review Letters. 2022;128(12).
doi:10.1103/PhysRevLett.128.126803
apa: Jirovec, D., Mutter, P. M., Hofmann, A. C., Crippa, A., Rychetsky, M., Craig,
D. L., … Katsaros, G. (2022). Dynamics of hole singlet-triplet qubits with large
g-factor differences. Physical Review Letters. American Physical Society.
https://doi.org/10.1103/PhysRevLett.128.126803
chicago: Jirovec, Daniel, Philipp M. Mutter, Andrea C Hofmann, Alessandro Crippa,
Marek Rychetsky, David L. Craig, Josip Kukucka, et al. “Dynamics of Hole Singlet-Triplet
Qubits with Large g-Factor Differences.” Physical Review Letters. American
Physical Society, 2022. https://doi.org/10.1103/PhysRevLett.128.126803.
ieee: D. Jirovec et al., “Dynamics of hole singlet-triplet qubits with large
g-factor differences,” Physical Review Letters, vol. 128, no. 12. American
Physical Society, 2022.
ista: Jirovec D, Mutter PM, Hofmann AC, Crippa A, Rychetsky M, Craig DL, Kukucka
J, Martins F, Ballabio A, Ares N, Chrastina D, Isella G, Burkard G, Katsaros G.
2022. Dynamics of hole singlet-triplet qubits with large g-factor differences.
Physical Review Letters. 128(12), 126803.
mla: Jirovec, Daniel, et al. “Dynamics of Hole Singlet-Triplet Qubits with Large
g-Factor Differences.” Physical Review Letters, vol. 128, no. 12, 126803,
American Physical Society, 2022, doi:10.1103/PhysRevLett.128.126803.
short: D. Jirovec, P.M. Mutter, A.C. Hofmann, A. Crippa, M. Rychetsky, D.L. Craig,
J. Kukucka, F. Martins, A. Ballabio, N. Ares, D. Chrastina, G. Isella, G. Burkard,
G. Katsaros, Physical Review Letters 128 (2022).
corr_author: '1'
date_created: 2022-03-24T15:51:11Z
date_published: 2022-03-24T00:00:00Z
date_updated: 2025-04-14T07:44:07Z
day: '24'
ddc:
- '530'
department:
- _id: GradSch
- _id: GeKa
doi: 10.1103/PhysRevLett.128.126803
ec_funded: 1
external_id:
arxiv:
- '2111.05130'
isi:
- '000786542500004'
pmid:
- '35394319'
file:
- access_level: open_access
checksum: 6e66ad548d18db9c131f304acbd5a1f4
content_type: application/pdf
creator: dernst
date_created: 2022-03-28T06:53:39Z
date_updated: 2022-03-28T06:53:39Z
file_id: '10928'
file_name: 2022_PhysRevLetters_Jirovec.pdf
file_size: 1266515
relation: main_file
success: 1
file_date_updated: 2022-03-28T06:53:39Z
has_accepted_license: '1'
intvolume: ' 128'
isi: 1
issue: '12'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 26A151DA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '844511'
name: Majorana bound states in Ge/SiGe heterostructures
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: 2641CE5E-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P30207
name: Hole spin orbit qubits in Ge quantum wells
- _id: c0977eea-5a5b-11eb-8a69-a862db0cf4d1
grant_number: I05060
name: High impedance circuit quantum electrodynamics with hole spins
- _id: c08c05c4-5a5b-11eb-8a69-dc6ce49d7973
grant_number: M03032
name: Long-range spin exchange for 2D qubits architectures
publication: Physical Review Letters
publication_identifier:
eissn:
- 1079-7114
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
record:
- id: '18291'
relation: popular_science
status: public
scopus_import: '1'
status: public
title: Dynamics of hole singlet-triplet qubits with large g-factor differences
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 128
year: '2022'
...
---
_id: '10922'
abstract:
- lang: eng
text: We study structural rigidity for assemblies with mechanical joints. Existing
methods identify whether an assembly is structurally rigid by assuming parts are
perfectly rigid. Yet, an assembly identified as rigid may not be that “rigid”
in practice, and existing methods cannot quantify how rigid an assembly is. We
address this limitation by developing a new measure, worst-case rigidity, to quantify
the rigidity of an assembly as the largest possible deformation that the assembly
undergoes for arbitrary external loads of fixed magnitude. Computing worst-case
rigidity is non-trivial due to non-rigid parts and different joint types. We thus
formulate a new computational approach by encoding parts and their connections
into a stiffness matrix, in which parts are modeled as deformable objects and
joints as soft constraints. Based on this, we formulate worst-case rigidity analysis
as an optimization that seeks the worst-case deformation of an assembly for arbitrary
external loads, and solve the optimization problem via an eigenanalysis. Furthermore,
we present methods to optimize the geometry and topology of various assemblies
to enhance their rigidity, as guided by our rigidity measure. In the end, we validate
our method on a variety of assembly structures with physical experiments and demonstrate
its effectiveness by designing and fabricating several structurally rigid assemblies.
acknowledged_ssus:
- _id: M-Shop
acknowledgement: "This work was supported by the Research Grants Council of the Hong
Kong Special Administrative Region, China [Project No.: CUHK 14201921] and the European
Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
programme (grant agreement No 715767 – MATERIALIZABLE). We thank the anonymous reviewers
for their insightful feedback; Christian Hafner for proofreading and discussions;
Ziqi Wang,\r\nHaisen Zhao, and Martin Hafskjold Thoresen for the helpful discussions;
and the Miba Machine Shop at IST Austria for 3D printing the BUNNY and BOOMERANG
models."
article_processing_charge: No
article_type: original
author:
- first_name: Zhenyuan
full_name: Liu, Zhenyuan
id: 70f0d7cf-ae65-11ec-a14f-89dfc5505b19
last_name: Liu
orcid: 0000-0001-9200-5690
- first_name: Jingyu
full_name: Hu, Jingyu
last_name: Hu
- first_name: Hao
full_name: Xu, Hao
last_name: Xu
- first_name: Peng
full_name: Song, Peng
last_name: Song
- first_name: Ran
full_name: Zhang, Ran
last_name: Zhang
- first_name: Bernd
full_name: Bickel, Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
- first_name: Chi-Wing
full_name: Fu, Chi-Wing
last_name: Fu
citation:
ama: Liu Z, Hu J, Xu H, et al. Worst-case rigidity analysis and optimization for
assemblies with mechanical joints. Computer Graphics Forum. 2022;41(2):507-519.
doi:10.1111/cgf.14490
apa: Liu, Z., Hu, J., Xu, H., Song, P., Zhang, R., Bickel, B., & Fu, C.-W. (2022).
Worst-case rigidity analysis and optimization for assemblies with mechanical joints.
Computer Graphics Forum. Wiley. https://doi.org/10.1111/cgf.14490
chicago: Liu, Zhenyuan, Jingyu Hu, Hao Xu, Peng Song, Ran Zhang, Bernd Bickel, and
Chi-Wing Fu. “Worst-Case Rigidity Analysis and Optimization for Assemblies with
Mechanical Joints.” Computer Graphics Forum. Wiley, 2022. https://doi.org/10.1111/cgf.14490.
ieee: Z. Liu et al., “Worst-case rigidity analysis and optimization for assemblies
with mechanical joints,” Computer Graphics Forum, vol. 41, no. 2. Wiley,
pp. 507–519, 2022.
ista: Liu Z, Hu J, Xu H, Song P, Zhang R, Bickel B, Fu C-W. 2022. Worst-case rigidity
analysis and optimization for assemblies with mechanical joints. Computer Graphics
Forum. 41(2), 507–519.
mla: Liu, Zhenyuan, et al. “Worst-Case Rigidity Analysis and Optimization for Assemblies
with Mechanical Joints.” Computer Graphics Forum, vol. 41, no. 2, Wiley,
2022, pp. 507–19, doi:10.1111/cgf.14490.
short: Z. Liu, J. Hu, H. Xu, P. Song, R. Zhang, B. Bickel, C.-W. Fu, Computer Graphics
Forum 41 (2022) 507–519.
date_created: 2022-03-27T17:34:17Z
date_published: 2022-05-01T00:00:00Z
date_updated: 2025-04-14T07:28:57Z
day: '01'
ddc:
- '000'
department:
- _id: BeBi
doi: 10.1111/cgf.14490
ec_funded: 1
external_id:
isi:
- '000802723900039'
file:
- access_level: open_access
checksum: b62188b07f5c000f1638c782ec92da41
content_type: application/pdf
creator: bbickel
date_created: 2022-03-27T17:34:11Z
date_updated: 2022-03-27T17:34:11Z
file_id: '10923'
file_name: paper.pdf
file_size: 19601689
relation: main_file
file_date_updated: 2022-03-27T17:34:11Z
has_accepted_license: '1'
intvolume: ' 41'
isi: 1
issue: '2'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Submitted Version
page: 507-519
project:
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715767'
name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
Modeling'
publication: Computer Graphics Forum
publication_identifier:
eissn:
- 1467-8659
issn:
- 0167-7055
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Worst-case rigidity analysis and optimization for assemblies with mechanical
joints
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 41
year: '2022'
...
---
_id: '10925'
abstract:
- lang: eng
text: Direct numerical simulations (DNS) of turbulent channel flows up to Reτ≈1000 are
conducted to investigate the three-dimensional (consisting of streamwise wavenumber,
spanwise wavenumber and frequency) spectrum of wall pressure fluctuations. To
develop a predictive model of the wavenumber–frequency spectrum from the wavenumber
spectrum, the time decorrelation mechanisms of wall pressure fluctuations are
investigated. It is discovered that the energy-containing part of the wavenumber–frequency
spectrum of wall pressure fluctuations can be well predicted using a similar random
sweeping model for streamwise velocity fluctuations. To refine the investigation,
we further decompose the spectrum of the total wall pressure fluctuations into
the autospectra of rapid and slow pressure fluctuations, and the cross-spectrum
between them. We focus on evaluating the assumption applied in many predictive
models, that is, the magnitude of the cross-spectrum is negligibly small. The
present DNS shows that neglecting the cross-spectrum causes a maximum error up
to 4.7 dB in the subconvective region for all Reynolds numbers under test. Our
analyses indicate that the approximation of neglecting the cross-spectrum needs
to be applied carefully in the investigations of acoustics at low Mach numbers,
in which the subconvective components of wall pressure fluctuations make important
contributions to the radiated acoustic power.
acknowledgement: This research is supported by the NSFC Basic Science Center Program
for ‘Multiscale Problems in Nonlinear Mechanics’ (no. 11988102), National Key Project
(GJXM92579) and the Strategic Priority Research Program (XDB22040104).
article_number: A39
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Bowen
full_name: Yang, Bowen
id: 71b6ff4b-15b2-11ec-abd3-aef6b028cf7e
last_name: Yang
orcid: 0000-0002-4843-6853
- first_name: Zixuan
full_name: Yang, Zixuan
last_name: Yang
citation:
ama: Yang B, Yang Z. On the wavenumber-frequency spectrum of the wall pressure fluctuations
in turbulent channel flow. Journal of Fluid Mechanics. 2022;937. doi:10.1017/jfm.2022.137
apa: Yang, B., & Yang, Z. (2022). On the wavenumber-frequency spectrum of the
wall pressure fluctuations in turbulent channel flow. Journal of Fluid Mechanics.
Cambridge University Press. https://doi.org/10.1017/jfm.2022.137
chicago: Yang, Bowen, and Zixuan Yang. “On the Wavenumber-Frequency Spectrum of
the Wall Pressure Fluctuations in Turbulent Channel Flow.” Journal of Fluid
Mechanics. Cambridge University Press, 2022. https://doi.org/10.1017/jfm.2022.137.
ieee: B. Yang and Z. Yang, “On the wavenumber-frequency spectrum of the wall pressure
fluctuations in turbulent channel flow,” Journal of Fluid Mechanics, vol.
937. Cambridge University Press, 2022.
ista: Yang B, Yang Z. 2022. On the wavenumber-frequency spectrum of the wall pressure
fluctuations in turbulent channel flow. Journal of Fluid Mechanics. 937, A39.
mla: Yang, Bowen, and Zixuan Yang. “On the Wavenumber-Frequency Spectrum of the
Wall Pressure Fluctuations in Turbulent Channel Flow.” Journal of Fluid Mechanics,
vol. 937, A39, Cambridge University Press, 2022, doi:10.1017/jfm.2022.137.
short: B. Yang, Z. Yang, Journal of Fluid Mechanics 937 (2022).
date_created: 2022-03-27T22:01:45Z
date_published: 2022-04-25T00:00:00Z
date_updated: 2023-08-03T06:20:26Z
day: '25'
department:
- _id: GradSch
doi: 10.1017/jfm.2022.137
external_id:
arxiv:
- '2201.04702'
isi:
- '000763547000001'
intvolume: ' 937'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1017/jfm.2022.137
month: '04'
oa: 1
oa_version: Published Version
publication: Journal of Fluid Mechanics
publication_identifier:
eissn:
- 1469-7645
issn:
- 0022-1120
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the wavenumber-frequency spectrum of the wall pressure fluctuations in turbulent
channel flow
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 937
year: '2022'
...
---
_id: '10926'
abstract:
- lang: eng
text: Conflict over reproduction between females and males exists because of anisogamy
and promiscuity. Together they generate differences in fitness optima between
the sexes and result in antagonistic coevolution of female and male reproductive
traits. Mounting duration is likely to be a compromise between male and female
interests whose outcome depends on the intensity of sexual selection. The timing
of sperm transfer during mounting is critical. For example, mountings may be interrupted
before sperm is transferred as a consequence of female or male choice, or they
may be prolonged to function as mate guarding. In the highly promiscuous intertidal
snail Littorina saxatilis, mountings vary substantially in duration, from less
than a minute to more than an hour, and it has been assumed that mountings of
a few minutes do not result in any sperm being transferred. Here, we examined
the timing of sperm transfer, a reproductive trait that is likely affected by
sexual conflict. We performed time-controlled mounting trials using L. saxatilis
males and virgin females, aiming to examine indirectly when the transfer of sperm
starts. We observed the relationship between mounting duration and the proportion
of developing embryos out of all eggs and embryos in the brood pouch. Developing
embryos were observed in similar proportions in all treatments (i.e. 1, 5 and
10 or more minutes at which mountings were artificially interrupted), suggesting
that sperm transfer begins rapidly (within 1 min) in L. saxatilis and very short
matings do not result in sperm shortage in the females. We discuss how the observed
pattern can be influenced by predation risk, population density, and female status
and receptivity.
article_number: eyab049
article_processing_charge: No
article_type: original
author:
- first_name: Samuel
full_name: Perini, Samuel
last_name: Perini
- first_name: Rogerk
full_name: Butlin, Rogerk
last_name: Butlin
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
citation:
ama: Perini S, Butlin R, Westram AM, Johannesson K. Very short mountings are enough
for sperm transfer in Littorina saxatilis. Journal of Molluscan Studies.
2022;88(1). doi:10.1093/mollus/eyab049
apa: Perini, S., Butlin, R., Westram, A. M., & Johannesson, K. (2022). Very
short mountings are enough for sperm transfer in Littorina saxatilis. Journal
of Molluscan Studies. Oxford University Press. https://doi.org/10.1093/mollus/eyab049
chicago: Perini, Samuel, Rogerk Butlin, Anja M Westram, and Kerstin Johannesson.
“Very Short Mountings Are Enough for Sperm Transfer in Littorina Saxatilis.” Journal
of Molluscan Studies. Oxford University Press, 2022. https://doi.org/10.1093/mollus/eyab049.
ieee: S. Perini, R. Butlin, A. M. Westram, and K. Johannesson, “Very short mountings
are enough for sperm transfer in Littorina saxatilis,” Journal of Molluscan
Studies, vol. 88, no. 1. Oxford University Press, 2022.
ista: Perini S, Butlin R, Westram AM, Johannesson K. 2022. Very short mountings
are enough for sperm transfer in Littorina saxatilis. Journal of Molluscan Studies.
88(1), eyab049.
mla: Perini, Samuel, et al. “Very Short Mountings Are Enough for Sperm Transfer
in Littorina Saxatilis.” Journal of Molluscan Studies, vol. 88, no. 1,
eyab049, Oxford University Press, 2022, doi:10.1093/mollus/eyab049.
short: S. Perini, R. Butlin, A.M. Westram, K. Johannesson, Journal of Molluscan
Studies 88 (2022).
date_created: 2022-03-27T22:01:46Z
date_published: 2022-03-01T00:00:00Z
date_updated: 2025-05-14T11:05:28Z
day: '01'
department:
- _id: BeVi
doi: 10.1093/mollus/eyab049
external_id:
isi:
- '000759081600002'
intvolume: ' 88'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://eprints.whiterose.ac.uk/187332/
month: '03'
oa: 1
oa_version: Submitted Version
publication: Journal of Molluscan Studies
publication_identifier:
eissn:
- 1464-3766
issn:
- 0260-1230
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Very short mountings are enough for sperm transfer in Littorina saxatilis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 88
year: '2022'
...
---
_id: '10927'
abstract:
- lang: eng
text: "Motivation\r\nHigh plasticity of bacterial genomes is provided by numerous
mechanisms including horizontal gene transfer and recombination via numerous flanking
repeats. Genome rearrangements such as inversions, deletions, insertions and duplications
may independently occur in different strains, providing parallel adaptation or
phenotypic diversity. Specifically, such rearrangements might be responsible for
virulence, antibiotic resistance and antigenic variation. However, identification
of such events requires laborious manual inspection and verification of phyletic
pattern consistency.\r\nResults\r\nHere, we define the term ‘parallel rearrangements’
as events that occur independently in phylogenetically distant bacterial strains
and present a formalization of the problem of parallel rearrangements calling.
We implement an algorithmic solution for the identification of parallel rearrangements
in bacterial populations as a tool PaReBrick. The tool takes a collection of strains
represented as a sequence of oriented synteny blocks and a phylogenetic tree as
input data. It identifies rearrangements, tests them for consistency with a tree,
and sorts the events by their parallelism score. The tool provides diagrams of
the neighbors for each block of interest, allowing the detection of horizontally
transferred blocks or their extra copies and the inversions in which copied blocks
are involved. We demonstrated PaReBrick’s efficiency and accuracy and showed its
potential to detect genome rearrangements responsible for pathogenicity and adaptation
in bacterial genomes."
acknowledgement: "The authors thank the 2020 student class of the Bioinformatics Institute,
who\r\nused the first versions of the tool and provided many valuable suggestions
to\r\nimprove usability. They also thank Louisa Gonzalez Somermeyer for manuscript
proofreading\r\nThis work was supported by the National Center for Cognitive Research
of\r\nITMO University and JetBrains Research [to A.Z and N.A.]; and the European\r\nUnion’s
Horizon 2020 Research and Innovation Programme under the Marie\r\nSkłodowska-Curie
[754411 to O.B.].\r\nPaReBrick is written in Python and is available on GitHub:
https://github.com/ctlab/parallel-rearrangements."
article_processing_charge: No
article_type: original
author:
- first_name: Alexey
full_name: Zabelkin, Alexey
last_name: Zabelkin
- first_name: Yulia
full_name: Yakovleva, Yulia
last_name: Yakovleva
- first_name: Olga
full_name: Bochkareva, Olga
id: C4558D3C-6102-11E9-A62E-F418E6697425
last_name: Bochkareva
orcid: 0000-0003-1006-6639
- first_name: Nikita
full_name: Alexeev, Nikita
last_name: Alexeev
citation:
ama: 'Zabelkin A, Yakovleva Y, Bochkareva O, Alexeev N. PaReBrick: PArallel REarrangements
and BReaks identification toolkit. Bioinformatics. 2022;38(2):357-363.
doi:10.1093/bioinformatics/btab691'
apa: 'Zabelkin, A., Yakovleva, Y., Bochkareva, O., & Alexeev, N. (2022). PaReBrick:
PArallel REarrangements and BReaks identification toolkit. Bioinformatics.
Oxford University Press. https://doi.org/10.1093/bioinformatics/btab691'
chicago: 'Zabelkin, Alexey, Yulia Yakovleva, Olga Bochkareva, and Nikita Alexeev.
“PaReBrick: PArallel REarrangements and BReaks Identification Toolkit.” Bioinformatics.
Oxford University Press, 2022. https://doi.org/10.1093/bioinformatics/btab691.'
ieee: 'A. Zabelkin, Y. Yakovleva, O. Bochkareva, and N. Alexeev, “PaReBrick: PArallel
REarrangements and BReaks identification toolkit,” Bioinformatics, vol.
38, no. 2. Oxford University Press, pp. 357–363, 2022.'
ista: 'Zabelkin A, Yakovleva Y, Bochkareva O, Alexeev N. 2022. PaReBrick: PArallel
REarrangements and BReaks identification toolkit. Bioinformatics. 38(2), 357–363.'
mla: 'Zabelkin, Alexey, et al. “PaReBrick: PArallel REarrangements and BReaks Identification
Toolkit.” Bioinformatics, vol. 38, no. 2, Oxford University Press, 2022,
pp. 357–63, doi:10.1093/bioinformatics/btab691.'
short: A. Zabelkin, Y. Yakovleva, O. Bochkareva, N. Alexeev, Bioinformatics 38 (2022)
357–363.
corr_author: '1'
date_created: 2022-03-27T22:01:46Z
date_published: 2022-01-15T00:00:00Z
date_updated: 2025-05-14T11:05:09Z
day: '15'
ddc:
- '000'
department:
- _id: FyKo
doi: 10.1093/bioinformatics/btab691
ec_funded: 1
external_id:
isi:
- '000743380100008'
file:
- access_level: open_access
checksum: 4b5688ff9ac86180ccdf7f82fa33d926
content_type: application/pdf
creator: dernst
date_created: 2022-03-28T08:07:46Z
date_updated: 2022-03-28T08:07:46Z
file_id: '10930'
file_name: 2022_Bioinformatics_Zabelkin.pdf
file_size: 3425744
relation: main_file
success: 1
file_date_updated: 2022-03-28T08:07:46Z
has_accepted_license: '1'
intvolume: ' 38'
isi: 1
issue: '2'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 357-363
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Bioinformatics
publication_identifier:
eissn:
- 1460-2059
issn:
- 1367-4803
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
related_material:
link:
- relation: software
url: https://github.com/ctlab/parallel-rearrangements
scopus_import: '1'
status: public
title: 'PaReBrick: PArallel REarrangements and BReaks identification toolkit'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 38
year: '2022'
...
---
_id: '10939'
abstract:
- lang: eng
text: Understanding and characterising biochemical processes inside single cells
requires experimental platforms that allow one to perturb and observe the dynamics
of such processes as well as computational methods to build and parameterise models
from the collected data. Recent progress with experimental platforms and optogenetics
has made it possible to expose each cell in an experiment to an individualised
input and automatically record cellular responses over days with fine time resolution.
However, methods to infer parameters of stochastic kinetic models from single-cell
longitudinal data have generally been developed under the assumption that experimental
data is sparse and that responses of cells to at most a few different input perturbations
can be observed. Here, we investigate and compare different approaches for calculating
parameter likelihoods of single-cell longitudinal data based on approximations
of the chemical master equation (CME) with a particular focus on coupling the
linear noise approximation (LNA) or moment closure methods to a Kalman filter.
We show that, as long as cells are measured sufficiently frequently, coupling
the LNA to a Kalman filter allows one to accurately approximate likelihoods and
to infer model parameters from data even in cases where the LNA provides poor
approximations of the CME. Furthermore, the computational cost of filtering-based
iterative likelihood evaluation scales advantageously in the number of measurement
times and different input perturbations and is thus ideally suited for data obtained
from modern experimental platforms. To demonstrate the practical usefulness of
these results, we perform an experiment in which single cells, equipped with an
optogenetic gene expression system, are exposed to various different light-input
sequences and measured at several hundred time points and use parameter inference
based on iterative likelihood evaluation to parameterise a stochastic model of
the system.
acknowledgement: We thank Virgile Andreani for useful discussions about the model
and parameter inference. We thank Johan Paulsson and Jeffrey J Tabor for kind gifts
of plasmids. R was supported by the ANR grant CyberCircuits (ANR-18-CE91-0002).
The funders had no role in study design, data collection and analysis, decision
to publish, or preparation of the manuscript.
article_number: e1009950
article_processing_charge: No
article_type: original
author:
- first_name: Anđela
full_name: Davidović, Anđela
last_name: Davidović
- first_name: Remy P
full_name: Chait, Remy P
id: 3464AE84-F248-11E8-B48F-1D18A9856A87
last_name: Chait
orcid: 0000-0003-0876-3187
- first_name: Gregory
full_name: Batt, Gregory
last_name: Batt
- first_name: Jakob
full_name: Ruess, Jakob
id: 4A245D00-F248-11E8-B48F-1D18A9856A87
last_name: Ruess
orcid: 0000-0003-1615-3282
citation:
ama: Davidović A, Chait RP, Batt G, Ruess J. Parameter inference for stochastic
biochemical models from perturbation experiments parallelised at the single cell
level. PLoS Computational Biology. 2022;18(3). doi:10.1371/journal.pcbi.1009950
apa: Davidović, A., Chait, R. P., Batt, G., & Ruess, J. (2022). Parameter inference
for stochastic biochemical models from perturbation experiments parallelised at
the single cell level. PLoS Computational Biology. Public Library of Science.
https://doi.org/10.1371/journal.pcbi.1009950
chicago: Davidović, Anđela, Remy P Chait, Gregory Batt, and Jakob Ruess. “Parameter
Inference for Stochastic Biochemical Models from Perturbation Experiments Parallelised
at the Single Cell Level.” PLoS Computational Biology. Public Library of
Science, 2022. https://doi.org/10.1371/journal.pcbi.1009950.
ieee: A. Davidović, R. P. Chait, G. Batt, and J. Ruess, “Parameter inference for
stochastic biochemical models from perturbation experiments parallelised at the
single cell level,” PLoS Computational Biology, vol. 18, no. 3. Public
Library of Science, 2022.
ista: Davidović A, Chait RP, Batt G, Ruess J. 2022. Parameter inference for stochastic
biochemical models from perturbation experiments parallelised at the single cell
level. PLoS Computational Biology. 18(3), e1009950.
mla: Davidović, Anđela, et al. “Parameter Inference for Stochastic Biochemical Models
from Perturbation Experiments Parallelised at the Single Cell Level.” PLoS
Computational Biology, vol. 18, no. 3, e1009950, Public Library of Science,
2022, doi:10.1371/journal.pcbi.1009950.
short: A. Davidović, R.P. Chait, G. Batt, J. Ruess, PLoS Computational Biology 18
(2022).
date_created: 2022-04-03T22:01:42Z
date_published: 2022-03-18T00:00:00Z
date_updated: 2025-09-09T14:29:53Z
day: '18'
ddc:
- '570'
- '000'
department:
- _id: CaGu
doi: 10.1371/journal.pcbi.1009950
external_id:
isi:
- '001044208400004'
pmid:
- '35303737'
file:
- access_level: open_access
checksum: 458ef542761fb714ced214f240daf6b2
content_type: application/pdf
creator: dernst
date_created: 2022-04-04T10:14:39Z
date_updated: 2022-04-04T10:14:39Z
file_id: '10947'
file_name: 2022_PLoSCompBio_Davidovic.pdf
file_size: 2958642
relation: main_file
success: 1
file_date_updated: 2022-04-04T10:14:39Z
has_accepted_license: '1'
intvolume: ' 18'
isi: 1
issue: '3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
publication: PLoS Computational Biology
publication_identifier:
eissn:
- 1553-7358
issn:
- 1553-734X
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
related_material:
link:
- relation: software
url: https://gitlab.pasteur.fr/adavidov/inferencelnakf
scopus_import: '1'
status: public
title: Parameter inference for stochastic biochemical models from perturbation experiments
parallelised at the single cell level
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 18
year: '2022'
...
---
_id: '10940'
abstract:
- lang: eng
text: 'Magnetic-field-resilient superconducting circuits enable sensing applications
and hybrid quantum computing architectures involving spin or topological qubits
and electromechanical elements, as well as studying flux noise and quasiparticle
loss. We investigate the effect of in-plane magnetic fields up to 1 T on the spectrum
and coherence times of thin-film three-dimensional aluminum transmons. Using a
copper cavity, unaffected by strong magnetic fields, we can probe solely the effect
of magnetic fields on the transmons. We present data on a single-junction and
a superconducting-quantum-interference-device (SQUID) transmon that are cooled
down in the same cavity. As expected, the transmon frequencies decrease with increasing
field, due to suppression of the superconducting gap and a geometric Fraunhofer-like
contribution. Nevertheless, the thin-film transmons show strong magnetic field
resilience: both transmons display microsecond coherence up to at least 0.65 T,
and T1 remains above 1μs over the entire measurable range. SQUID spectroscopy
is feasible up to 1 T, the limit of our magnet. We conclude that thin-film aluminum
Josephson junctions are suitable hardware for superconducting circuits in the
high-magnetic-field regime.'
acknowledgement: "We would like to thank Ida Milow for her internship in the laboratory
and contributions to our code base. We thank T. Zent and L. Hamdan for technical
assistance, and D. Fan for help with setting up the aluminum evaporator. We thank
A. Salari, M. Rößler, S. Barzanjeh, M. Zemlicka, F. Hassani, and M. Peruzzo for
contributions in the early stages of the experiments. This project has received
funding from the European Research Council (ERC) under the European Union’s Horizon
2020 research and innovation program (Grant Agreement No. 741121) and was also funded
by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under CRC
1238 – 277146847 (Subproject B01), as well as under Germany’s Excellence Strategy
– Cluster of Excellence Matter and Light for Quantum Computing (ML4Q), EXC 2004/1\r\n–
390534769."
article_number: '034032'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: J.
full_name: Krause, J.
last_name: Krause
- first_name: C.
full_name: Dickel, C.
last_name: Dickel
- first_name: E.
full_name: Vaal, E.
last_name: Vaal
- first_name: M.
full_name: Vielmetter, M.
last_name: Vielmetter
- first_name: J.
full_name: Feng, J.
last_name: Feng
- first_name: R.
full_name: Bounds, R.
last_name: Bounds
- first_name: G.
full_name: Catelani, G.
last_name: Catelani
- first_name: Johannes M
full_name: Fink, Johannes M
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
- first_name: Yoichi
full_name: Ando, Yoichi
last_name: Ando
citation:
ama: Krause J, Dickel C, Vaal E, et al. Magnetic field resilience of three-dimensional
transmons with thin-film Al/AlOx/Al Josephson junctions approaching 1 T. Physical
Review Applied. 2022;17(3). doi:10.1103/PhysRevApplied.17.034032
apa: Krause, J., Dickel, C., Vaal, E., Vielmetter, M., Feng, J., Bounds, R., … Ando,
Y. (2022). Magnetic field resilience of three-dimensional transmons with thin-film
Al/AlOx/Al Josephson junctions approaching 1 T. Physical Review Applied.
American Physical Society. https://doi.org/10.1103/PhysRevApplied.17.034032
chicago: Krause, J., C. Dickel, E. Vaal, M. Vielmetter, J. Feng, R. Bounds, G. Catelani,
Johannes M Fink, and Yoichi Ando. “Magnetic Field Resilience of Three-Dimensional
Transmons with Thin-Film Al/AlOx/Al Josephson Junctions Approaching 1 T.” Physical
Review Applied. American Physical Society, 2022. https://doi.org/10.1103/PhysRevApplied.17.034032.
ieee: J. Krause et al., “Magnetic field resilience of three-dimensional transmons
with thin-film Al/AlOx/Al Josephson junctions approaching 1 T,” Physical Review
Applied, vol. 17, no. 3. American Physical Society, 2022.
ista: Krause J, Dickel C, Vaal E, Vielmetter M, Feng J, Bounds R, Catelani G, Fink
JM, Ando Y. 2022. Magnetic field resilience of three-dimensional transmons with
thin-film Al/AlOx/Al Josephson junctions approaching 1 T. Physical Review Applied.
17(3), 034032.
mla: Krause, J., et al. “Magnetic Field Resilience of Three-Dimensional Transmons
with Thin-Film Al/AlOx/Al Josephson Junctions Approaching 1 T.” Physical Review
Applied, vol. 17, no. 3, 034032, American Physical Society, 2022, doi:10.1103/PhysRevApplied.17.034032.
short: J. Krause, C. Dickel, E. Vaal, M. Vielmetter, J. Feng, R. Bounds, G. Catelani,
J.M. Fink, Y. Ando, Physical Review Applied 17 (2022).
date_created: 2022-04-03T22:01:43Z
date_published: 2022-03-11T00:00:00Z
date_updated: 2023-08-03T06:23:58Z
day: '11'
department:
- _id: JoFi
doi: 10.1103/PhysRevApplied.17.034032
external_id:
arxiv:
- '2111.01115'
isi:
- '000770371400003'
intvolume: ' 17'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2111.01115
month: '03'
oa: 1
oa_version: Preprint
publication: Physical Review Applied
publication_identifier:
eissn:
- 2331-7019
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Magnetic field resilience of three-dimensional transmons with thin-film Al/AlOx/Al
Josephson junctions approaching 1 T
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 17
year: '2022'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '10945'
abstract:
- lang: eng
text: Mica-titania pearlescent pigments (MTs) were previously coated with organic
molecules to obtain combination pigments (CPs) for achieving certain improvements
or functionalities. Anthocyanins (ACNs) are molecules that can be extracted from
natural resources and exhibit color changes via pH modifications of the enclosing
medium. The purpose of the study was to produce a new series of CPs by depositing
ACNs on MTs at different pH values, to observe the changes in color, and to associate
these changes to thermogravimetrically determined deposition efficiencies in light
of spectral differences. The extraction and deposition methods were based on aqueous
chemistry and were straightforward. The ACN deposition generally increased with
increasing pH and correlated with the consistency between the charges of the MT
surfaces and the dominant ACN species at a specific pH value. The fluorescence
of the CPs was inversely correlated with the deposition quantities invoking the
possibility of a quenching effect.
acknowledgement: "This research was partly funded by Hacettepe University (Bilimsel
Ara¸stırma Projeleri\r\nKoordinasyon Birimi), grant number FHD-2015-8094.The authors
are indebted to Ahmet Önal for his supports in acquiring the fluorescence spectra
and the decision of excitation wavelengths. The authors also acknowledge use of
the services and facilities of UNAM-National Nanotechnology Research Center at Bilkent
University and mica donation from Sabuncular Mining Co."
article_processing_charge: Yes
article_type: original
author:
- first_name: Mehmet Orkun
full_name: Çoruh, Mehmet Orkun
id: d25163e5-8d53-11eb-a251-e6dd8ea1b8ef
last_name: Çoruh
orcid: 0000-0002-3219-2022
- first_name: Güngör
full_name: Gündüz, Güngör
last_name: Gündüz
- first_name: Üner
full_name: Çolak, Üner
last_name: Çolak
- first_name: Bora
full_name: Maviş, Bora
last_name: Maviş
citation:
ama: Çoruh MO, Gündüz G, Çolak Ü, Maviş B. pH-dependent coloring of combination
effect pigments with anthocyanins from Brassica oleracea var. capitata F. rubra.
Colorants. 2022;1(2):149-164. doi:10.3390/colorants1020010
apa: Çoruh, M. O., Gündüz, G., Çolak, Ü., & Maviş, B. (2022). pH-dependent coloring
of combination effect pigments with anthocyanins from Brassica oleracea var. capitata
F. rubra. Colorants. MDPI. https://doi.org/10.3390/colorants1020010
chicago: Çoruh, Mehmet Orkun, Güngör Gündüz, Üner Çolak, and Bora Maviş. “PH-Dependent
Coloring of Combination Effect Pigments with Anthocyanins from Brassica Oleracea
Var. Capitata F. Rubra.” Colorants. MDPI, 2022. https://doi.org/10.3390/colorants1020010.
ieee: M. O. Çoruh, G. Gündüz, Ü. Çolak, and B. Maviş, “pH-dependent coloring of
combination effect pigments with anthocyanins from Brassica oleracea var. capitata
F. rubra,” Colorants, vol. 1, no. 2. MDPI, pp. 149–164, 2022.
ista: Çoruh MO, Gündüz G, Çolak Ü, Maviş B. 2022. pH-dependent coloring of combination
effect pigments with anthocyanins from Brassica oleracea var. capitata F. rubra.
Colorants. 1(2), 149–164.
mla: Çoruh, Mehmet Orkun, et al. “PH-Dependent Coloring of Combination Effect Pigments
with Anthocyanins from Brassica Oleracea Var. Capitata F. Rubra.” Colorants,
vol. 1, no. 2, MDPI, 2022, pp. 149–64, doi:10.3390/colorants1020010.
short: M.O. Çoruh, G. Gündüz, Ü. Çolak, B. Maviş, Colorants 1 (2022) 149–164.
date_created: 2022-04-04T09:03:54Z
date_published: 2022-04-01T00:00:00Z
date_updated: 2024-10-14T13:52:09Z
day: '01'
ddc:
- '570'
department:
- _id: LeSa
doi: 10.3390/colorants1020010
file:
- access_level: open_access
checksum: 2c15c8d3041ebc36bc64870247081758
content_type: application/pdf
creator: dernst
date_created: 2022-04-04T10:39:24Z
date_updated: 2022-04-04T10:39:24Z
file_id: '10949'
file_name: 2022_Colorants_Coruh.pdf
file_size: 2437988
relation: main_file
success: 1
file_date_updated: 2022-04-04T10:39:24Z
has_accepted_license: '1'
intvolume: ' 1'
issue: '2'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 149-164
publication: Colorants
publication_identifier:
issn:
- 2079-6447
publication_status: published
publisher: MDPI
quality_controlled: '1'
status: public
title: pH-dependent coloring of combination effect pigments with anthocyanins from
Brassica oleracea var. capitata F. rubra
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 0043cee0-e5fc-11ee-9736-f83bc23afbf0
volume: 1
year: '2022'
...
---
_id: '11051'
abstract:
- lang: eng
text: Nuclear pore complexes (NPCs) bridge the nucleus and the cytoplasm and are
indispensable for crucial cellular activities, such as bidirectional molecular
trafficking and gene transcription regulation. The discovery of long-lived proteins
(LLPs) in NPCs from postmitotic cells raises the exciting possibility that the
maintenance of NPC integrity might play an inherent role in lifelong cell function.
Age-dependent deterioration of NPCs and loss of nuclear integrity have been linked
to age-related decline in postmitotic cell function and degenerative diseases.
In this review, we discuss our current understanding of NPC maintenance in proliferating
and postmitotic cells, and how malfunction of nucleoporins (Nups) might contribute
to the pathogenesis of various neurodegenerative and cardiovascular diseases.
article_processing_charge: No
article_type: review
author:
- first_name: Jinqiang
full_name: Liu, Jinqiang
last_name: Liu
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Liu J, Hetzer M. Nuclear pore complex maintenance and implications for age-related
diseases. Trends in Cell Biology. 2022;32(3):P216-227. doi:10.1016/j.tcb.2021.10.001
apa: Liu, J., & Hetzer, M. (2022). Nuclear pore complex maintenance and implications
for age-related diseases. Trends in Cell Biology. Elsevier. https://doi.org/10.1016/j.tcb.2021.10.001
chicago: Liu, Jinqiang, and Martin Hetzer. “Nuclear Pore Complex Maintenance and
Implications for Age-Related Diseases.” Trends in Cell Biology. Elsevier,
2022. https://doi.org/10.1016/j.tcb.2021.10.001.
ieee: J. Liu and M. Hetzer, “Nuclear pore complex maintenance and implications for
age-related diseases,” Trends in Cell Biology, vol. 32, no. 3. Elsevier,
pp. P216-227, 2022.
ista: Liu J, Hetzer M. 2022. Nuclear pore complex maintenance and implications for
age-related diseases. Trends in Cell Biology. 32(3), P216-227.
mla: Liu, Jinqiang, and Martin Hetzer. “Nuclear Pore Complex Maintenance and Implications
for Age-Related Diseases.” Trends in Cell Biology, vol. 32, no. 3, Elsevier,
2022, pp. P216-227, doi:10.1016/j.tcb.2021.10.001.
short: J. Liu, M. Hetzer, Trends in Cell Biology 32 (2022) P216-227.
date_created: 2022-04-07T07:43:01Z
date_published: 2022-03-01T00:00:00Z
date_updated: 2024-10-14T11:14:57Z
day: '01'
doi: 10.1016/j.tcb.2021.10.001
extern: '1'
external_id:
pmid:
- '34782239'
intvolume: ' 32'
issue: '3'
keyword:
- Cell Biology
language:
- iso: eng
month: '03'
oa_version: None
page: P216-227
pmid: 1
publication: Trends in Cell Biology
publication_identifier:
issn:
- 0962-8924
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nuclear pore complex maintenance and implications for age-related diseases
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 32
year: '2022'
...