---
OA_place: repository
OA_type: green
_id: '21242'
abstract:
- lang: eng
text: We obtain an asymptotic formula for the number of integral solutions to a
system of diagonal equations. We obtain an asymptotic formula for the number of
solutions with variables restricted to smooth numbers as well. We improve the
required number of variables compared to previous results by incorporating recent
progress on Waring’s problem and the resolution of the main conjecture in Vinogradov’s
mean value theorem.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Nick
full_name: Rome, Nick
last_name: Rome
- first_name: Shuntaro
full_name: Yamagishi, Shuntaro
id: 0c3fbc5c-f7a6-11ec-8d70-9485e75b416b
last_name: Yamagishi
citation:
ama: Rome N, Yamagishi S. Integral solutions to systems of diagonal equations. Pacific
Journal of Mathematics. 2026;340(1):179-198. doi:10.2140/pjm.2026.340.179
apa: Rome, N., & Yamagishi, S. (2026). Integral solutions to systems of diagonal
equations. Pacific Journal of Mathematics. Mathematical Sciences Publishers.
https://doi.org/10.2140/pjm.2026.340.179
chicago: Rome, Nick, and Shuntaro Yamagishi. “Integral Solutions to Systems of Diagonal
Equations.” Pacific Journal of Mathematics. Mathematical Sciences Publishers,
2026. https://doi.org/10.2140/pjm.2026.340.179.
ieee: N. Rome and S. Yamagishi, “Integral solutions to systems of diagonal equations,”
Pacific Journal of Mathematics, vol. 340, no. 1. Mathematical Sciences
Publishers, pp. 179–198, 2026.
ista: Rome N, Yamagishi S. 2026. Integral solutions to systems of diagonal equations.
Pacific Journal of Mathematics. 340(1), 179–198.
mla: Rome, Nick, and Shuntaro Yamagishi. “Integral Solutions to Systems of Diagonal
Equations.” Pacific Journal of Mathematics, vol. 340, no. 1, Mathematical
Sciences Publishers, 2026, pp. 179–98, doi:10.2140/pjm.2026.340.179.
short: N. Rome, S. Yamagishi, Pacific Journal of Mathematics 340 (2026) 179–198.
das_tickbox: '0'
date_created: 2026-02-16T15:17:27Z
date_published: 2026-01-01T00:00:00Z
date_updated: 2026-07-16T08:36:20Z
day: '01'
department:
- _id: TiBr
doi: 10.2140/pjm.2026.340.179
external_id:
arxiv:
- '2406.09256'
intvolume: ' 340'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2406.09256
month: '01'
oa: 1
oa_version: Preprint
page: 179-198
publication: Pacific Journal of Mathematics
publication_identifier:
eissn:
- 1945-5844
issn:
- 0030-8730
publication_status: published
publisher: Mathematical Sciences Publishers
quality_controlled: '1'
researchdata_availability: no
status: public
supplementarymaterial: no
title: Integral solutions to systems of diagonal equations
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 340
year: '2026'
...
---
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '22318'
abstract:
- lang: eng
text: "Many intended uses of differential privacy involve a continual mechanism
that is set up to run continuously\r\nover a long period of time, making more
statistical releases as either queries come in or the dataset is updated.\r\nIn
this paper, we give the first general treatment of privacy against adaptive adversaries
for mechanisms that\r\nsupport dataset updates and a variety of queries, all arbitrarily
interleaved. It also models a very general notion\r\nof neighboring, that includes
both event-level and user-level privacy. We prove several concurrent composition\r\ntheorems
for continual mechanisms, which ensure privacy even when an adversary can interleave
its queries\r\nand dataset updates to the different composed mechanisms. Previous
concurrent composition theorems for\r\ndifferential privacy were only for the
case when the dataset is static, with no adaptive updates. We also give\r\nthe
first interactive and continual generalizations of the “parallel composition theorem”
for noninteractive\r\ndifferential privacy. Specifically, we show that the analogue
of the noninteractive parallel composition theorem\r\nholds if either there are
no adaptive dataset updates or each of the composed mechanisms satisfies pure\r\ndifferential
privacy, but it fails to hold for composing approximately differentially private
mechanisms with\r\ndataset updates. Thus, we prove a tight new composition theorem
for this case. In addition, we prove concurrent\r\nfilter compositions theorems
for the scenarios in which the privacy parameters are adaptively chosen. We\r\nextend
these results to other measures of differential privacy, including Rényi DP and
\U0001D453 -DP.\r\nWe then formalize a set of general conditions on a continual
mechanism M that runs multiple continual submechanisms such that the privacy guarantees
of M follow directly using the above concurrent composition\r\ntheorems on the
sub-mechanisms, without further privacy loss. This enables us to give a simpler
and modular\r\nprivacy analysis of a recent continual histogram mechanism of Henzinger,
Sricharan, and Steiner. In the\r\ncase of approximate DP, ours is the first proof
that shows that its privacy holds against adaptive adversaries.\r\nWe also provide
a framework that simplifies the analysis of local differential privacy when the
protocol\r\nincludes multi-round server-user interactions. Using this result,
we simplify the privacy analysis of the core\r\ndecomposition protocol of Dhulipala,
Henzinger, Li, Liu, Sricharan, and Zhu [5]."
acknowledgement: "1Salil Vadhan was supported by NSF grant BCS-2218803, a grant from
the Sloan Foundation, and\r\na Simons Investigator Award. Work began while a Visiting
Researcher at the Bocconi University\r\nDepartment of Computing Sciences, supported
by Luca Trevisan’s ERC Project GA-834861.\r\n2Monika Henzinger and Roodabeh Safavi
were supported by the European Research Council (ERC)\r\nunder the European Union’s
Horizon 2020 research and innovation programme (Grant agreement\r\nNo. 101019564),
and the Austrian Science Fund (FWF) under grants DOI 10.55776/Z422, DOI\r\n10.55776/I5982,
and DOI 10.55776/P33775. For open access purposes, the author has applied a CC BY\r\npublic
copyright license to any author-accepted manuscript version arising from this submission.\r\nViews
and opinions expressed are however those of the author(s)\r\nonly and do not necessarily
reflect those of the European Union\r\nor the European Research Council Executive
Agency. Neither the\r\nEuropean Union nor the granting authority can be held responsible
for them."
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Roodabeh
full_name: Safavi Hemami, Roodabeh
id: 72ed2640-8972-11ed-ae7b-f9c81ec75154
last_name: Safavi Hemami
- first_name: Salil
full_name: Vadhan, Salil
last_name: Vadhan
citation:
ama: Henzinger M, Safavi Hemami R, Vadhan S. Concurrent composition for differentially
private continual mechanisms. Proceedings of the ACM on Management of Data.
2026;4(2):1-26. doi:10.1145/3801895
apa: Henzinger, M., Safavi Hemami, R., & Vadhan, S. (2026). Concurrent composition
for differentially private continual mechanisms. Proceedings of the ACM on
Management of Data. Association for Computing Machinery. https://doi.org/10.1145/3801895
chicago: Henzinger, Monika, Roodabeh Safavi Hemami, and Salil Vadhan. “Concurrent
Composition for Differentially Private Continual Mechanisms.” Proceedings of
the ACM on Management of Data. Association for Computing Machinery, 2026.
https://doi.org/10.1145/3801895.
ieee: M. Henzinger, R. Safavi Hemami, and S. Vadhan, “Concurrent composition for
differentially private continual mechanisms,” Proceedings of the ACM on Management
of Data, vol. 4, no. 2. Association for Computing Machinery, pp. 1–26, 2026.
ista: Henzinger M, Safavi Hemami R, Vadhan S. 2026. Concurrent composition for differentially
private continual mechanisms. Proceedings of the ACM on Management of Data. 4(2),
1–26.
mla: Henzinger, Monika, et al. “Concurrent Composition for Differentially Private
Continual Mechanisms.” Proceedings of the ACM on Management of Data, vol.
4, no. 2, Association for Computing Machinery, 2026, pp. 1–26, doi:10.1145/3801895.
short: M. Henzinger, R. Safavi Hemami, S. Vadhan, Proceedings of the ACM on Management
of Data 4 (2026) 1–26.
corr_author: '1'
das_tickbox: '0'
date_created: 2026-07-13T14:59:14Z
date_published: 2026-06-01T00:00:00Z
date_updated: 2026-07-16T09:14:49Z
day: '01'
ddc:
- '000'
department:
- _id: MoHe
doi: 10.1145/3801895
ec_funded: 1
external_id:
arxiv:
- '2411.03299'
file:
- access_level: open_access
checksum: c6c5e256d02b90682c0690c3bee94040
content_type: application/pdf
creator: dernst
date_created: 2026-07-16T09:09:53Z
date_updated: 2026-07-16T09:09:53Z
file_id: '22345'
file_name: 2026_ACMMgmtData_Henzinger.pdf
file_size: 655405
relation: main_file
success: 1
file_date_updated: 2026-07-16T09:09:53Z
has_accepted_license: '1'
intvolume: ' 4'
issue: '2'
keyword:
- differential privacy
- concurrent composition
- continual release
- continual observation
- data streaming
- continual mechanisms
- concurrent parallel composition
- concurrent filter composition
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 1-26
project:
- _id: bd9ca328-d553-11ed-ba76-dc4f890cfe62
call_identifier: H2020
grant_number: '101019564'
name: The design and evaluation of modern fully dynamic data structures
- _id: bda196b2-d553-11ed-ba76-8e8ee6c21103
grant_number: I05982
name: Static and Dynamic Hierarchical Graph Decompositions
- _id: bd9e3a2e-d553-11ed-ba76-8aa684ce17fe
grant_number: P33775
name: Fast Algorithms for a Reactive Network Layer
- _id: 34def286-11ca-11ed-8bc3-da5948e1613c
grant_number: Z00422
name: Efficient algorithms
publication: Proceedings of the ACM on Management of Data
publication_identifier:
issn:
- 2836-6573
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Concurrent composition for differentially private continual mechanisms
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '22294'
abstract:
- lang: eng
text: 'Modern computer systems store vast amounts of personal data, enabling advances
in AI and ML but risking user privacy and trust. For privacy reasons, it is sometimes
desired for an ML model to forget part of the data it was trained on. In this
paper, we introduce a novel unlearning approach based on Forgetting Neural Networks
(FNNs), a neuroscience-inspired architecture that explicitly encodes forgetting
through multiplicative decay factors. While FNNs had previously been studied as
a theoretical construct, we provide the first concrete implementation and demonstrate
their effectiveness for targeted unlearning. We propose several variants with
per-neuron forgetting factors, including rank-based assignments guided by activation
levels, and evaluate them on MNIST and Fashion-MNIST benchmarks. Our method systematically
removes information associated with forget sets while preserving performance on
retained data. Membership inference attacks confirm the effectiveness of FNN-based
unlearning in erasing information about the training data from the neural network.
These results establish FNNs as a promising foundation for efficient and interpretable
unlearning. '
article_processing_charge: No
arxiv: 1
author:
- first_name: Amartya
full_name: Hatua, Amartya
last_name: Hatua
- first_name: Trung
full_name: Nguyen, Trung
last_name: Nguyen
- first_name: Filip
full_name: Cano Cordoba, Filip
id: 708cad98-e86a-11ef-8098-bdae2d7c6af1
last_name: Cano Cordoba
orcid: 0000-0002-0783-904X
- first_name: Andrew
full_name: Sung, Andrew
last_name: Sung
citation:
ama: 'Hatua A, Nguyen T, Cano Cordoba F, Sung A. Machine unlearning using forgetting
neural networks. In: Proceedings of the 18th International Conference on Agents
and Artificial Intelligence. Vol 2. SciTePress; 2026:1536-1546. doi:10.5220/0014326500004052'
apa: 'Hatua, A., Nguyen, T., Cano Cordoba, F., & Sung, A. (2026). Machine unlearning
using forgetting neural networks. In Proceedings of the 18th International
Conference on Agents and Artificial Intelligence (Vol. 2, pp. 1536–1546).
Marbella, Spain: SciTePress. https://doi.org/10.5220/0014326500004052'
chicago: Hatua, Amartya, Trung Nguyen, Filip Cano Cordoba, and Andrew Sung. “Machine
Unlearning Using Forgetting Neural Networks.” In Proceedings of the 18th International
Conference on Agents and Artificial Intelligence, 2:1536–46. SciTePress, 2026.
https://doi.org/10.5220/0014326500004052.
ieee: A. Hatua, T. Nguyen, F. Cano Cordoba, and A. Sung, “Machine unlearning using
forgetting neural networks,” in Proceedings of the 18th International Conference
on Agents and Artificial Intelligence, Marbella, Spain, 2026, vol. 2, pp.
1536–1546.
ista: 'Hatua A, Nguyen T, Cano Cordoba F, Sung A. 2026. Machine unlearning using
forgetting neural networks. Proceedings of the 18th International Conference on
Agents and Artificial Intelligence. ICAART: International Conference on Agents
and Artificial Intelligence vol. 2, 1536–1546.'
mla: Hatua, Amartya, et al. “Machine Unlearning Using Forgetting Neural Networks.”
Proceedings of the 18th International Conference on Agents and Artificial Intelligence,
vol. 2, SciTePress, 2026, pp. 1536–46, doi:10.5220/0014326500004052.
short: A. Hatua, T. Nguyen, F. Cano Cordoba, A. Sung, in:, Proceedings of the 18th
International Conference on Agents and Artificial Intelligence, SciTePress, 2026,
pp. 1536–1546.
conference:
end_date: 2026-03-08
location: Marbella, Spain
name: 'ICAART: International Conference on Agents and Artificial Intelligence'
start_date: 2026-03-05
das_tickbox: '1'
date_created: 2026-07-13T09:46:46Z
date_published: 2026-06-30T00:00:00Z
date_updated: 2026-07-16T09:02:53Z
day: '30'
department:
- _id: ToHe
doi: 10.5220/0014326500004052
external_id:
arxiv:
- '2410.22374'
intvolume: ' 2'
keyword:
- Machine Unlearning
- Neuroscience-Inspired Machine Learning
- Membership Inference Attacks
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2410.22374
month: '06'
oa: 1
oa_version: Preprint
page: 1536-1546
publication: Proceedings of the 18th International Conference on Agents and Artificial
Intelligence
publication_identifier:
eissn:
- 2184-433X
isbn:
- '9789897587962'
publication_status: published
publisher: SciTePress
quality_controlled: '1'
scopus_import: '1'
status: public
title: Machine unlearning using forgetting neural networks
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2
year: '2026'
...
---
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '22322'
abstract:
- lang: eng
text: "We study the problem of continually releasing statistics of an evolving dataset
under differential privacy. In the event-level setting, we show the first polynomial
lower bounds on the additive error for insertions-only graph problems such as
maximum matching, degree histogram and k-core number computation. These results
represent an exponential improvement on the polylogarithmic lower bounds of Fichtenberger,
Henzinger and Ost [ESA 2021] for the former two problems, and are the first lower
bounds in the continual release setting for the latter problem. Our results run
counter to the intuition that the difference between insertions-only vs fully
dynamic updates causes the gap between polylogarithmic and polynomial additive
error. Indeed, we show that for estimating the size of the maximum matching or
k-core number of a vertex, allowing small multiplicative approximations is what
brings the additive error down to polylogarithmic. We complement these results
with improved upper bounds on the additive error when no multiplicative approximation
is allowed.\r\nBeyond graphs, our techniques also show that polynomial additive
error is unavoidable for the Simultaneous Norm Estimation problem in the insertions-only
setting. When multiplicative approximations are allowed, we circumvent this lower
bound by giving the first continual mechanism with polylogarithmic additive error
under (1 + ζ) multiplicative approximations, for any ζ > 0, for estimating all
monotone symmetric norms simultaneously.\r\nIn the item-level setting, we show
polynomial lower bounds on the product of the multiplicative and the additive
error of continual mechanisms for a large range of graph problems. To the best
of our knowledge, these are the first lower bounds shown for any differentially
private mechanism under continual release with multiplicative error. To obtain
these results, we prove a new lower bound on the product of multiplicative and
additive error for the 1-Way-Marginals problem, and give reductions from 1-Way-Marginals
to our desired graph problems. This generalizes the prior results of Hardt and
Talwar [STOC 2010] and Bun, Ullman and Vadhan [STOC 2014, SIAM J. Comput. 2018],
who gave lower bounds on the additive error for the special case of mechanisms
with no multiplicative error."
acknowledgement: "Bardiya Aryanfard and Monika Henzinger were supported by the European
Research Council (ERC)\r\nunder the European Union’s Horizon 2020 research and innovation
programme (Grant agreement\r\nNo. 101019564). For open access purposes, the author
has applied a CC BY public copyright\r\nlicense to any author-accepted manuscript
version arising from this submission. Funded by the\r\nEuropean union. Views and
opinions expressed are however those of the author(s) only and do\r\nnot necessarily
reflect those of the European Union or the European Research Council Executive\r\nAgency.
Neither the European Union nor the granting authority can be held responsible for
them"
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Bardiya
full_name: Aryanfard, Bardiya
id: 1e8f4084-31df-11ee-b195-f706b4b77091
last_name: Aryanfard
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: David
full_name: Saulpic, David
id: f8e48cf0-b0ff-11ed-b0e9-b4c35598f964
last_name: Saulpic
- first_name: A. R.
full_name: Sricharan, A. R.
last_name: Sricharan
citation:
ama: Aryanfard B, Henzinger M, Saulpic D, Sricharan AR. Improved lower bounds for
privacy under continual release. Proceedings of the ACM on Management of Data.
2026;4(2):1-27. doi:10.1145/3801903
apa: Aryanfard, B., Henzinger, M., Saulpic, D., & Sricharan, A. R. (2026). Improved
lower bounds for privacy under continual release. Proceedings of the ACM on
Management of Data. Association for Computing Machinery. https://doi.org/10.1145/3801903
chicago: Aryanfard, Bardiya, Monika Henzinger, David Saulpic, and A. R. Sricharan.
“Improved Lower Bounds for Privacy under Continual Release.” Proceedings of
the ACM on Management of Data. Association for Computing Machinery, 2026.
https://doi.org/10.1145/3801903.
ieee: B. Aryanfard, M. Henzinger, D. Saulpic, and A. R. Sricharan, “Improved lower
bounds for privacy under continual release,” Proceedings of the ACM on Management
of Data, vol. 4, no. 2. Association for Computing Machinery, pp. 1–27, 2026.
ista: Aryanfard B, Henzinger M, Saulpic D, Sricharan AR. 2026. Improved lower bounds
for privacy under continual release. Proceedings of the ACM on Management of Data.
4(2), 1–27.
mla: Aryanfard, Bardiya, et al. “Improved Lower Bounds for Privacy under Continual
Release.” Proceedings of the ACM on Management of Data, vol. 4, no. 2,
Association for Computing Machinery, 2026, pp. 1–27, doi:10.1145/3801903.
short: B. Aryanfard, M. Henzinger, D. Saulpic, A.R. Sricharan, Proceedings of the
ACM on Management of Data 4 (2026) 1–27.
corr_author: '1'
das_tickbox: '0'
date_created: 2026-07-14T05:33:58Z
date_published: 2026-06-01T00:00:00Z
date_updated: 2026-07-16T09:30:31Z
day: '01'
ddc:
- '000'
department:
- _id: MoHe
- _id: GradSch
doi: 10.1145/3801903
ec_funded: 1
external_id:
arxiv:
- '2512.15981'
file:
- access_level: open_access
checksum: 21a48a620e415a31a3874077c55bc6c3
content_type: application/pdf
creator: dernst
date_created: 2026-07-16T09:29:08Z
date_updated: 2026-07-16T09:29:08Z
file_id: '22349'
file_name: 2026_ACMMgmtData_Aryanfard.pdf
file_size: 934963
relation: main_file
success: 1
file_date_updated: 2026-07-16T09:29:08Z
has_accepted_license: '1'
intvolume: ' 4'
issue: '2'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 1-27
project:
- _id: bd9ca328-d553-11ed-ba76-dc4f890cfe62
call_identifier: H2020
grant_number: '101019564'
name: The design and evaluation of modern fully dynamic data structures
publication: Proceedings of the ACM on Management of Data
publication_identifier:
issn:
- 2836-6573
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Improved lower bounds for privacy under continual release
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22326'
abstract:
- lang: eng
text: In many developmental systems, cells differentiate into a tissue by reading
out morphogen concentration fields, a process fundamentally limited by noise.
How much can the precision of this process be improved by nonlocal information,
e.g., via cell-cell communication? Using a Bayes-optimal framework, we show that
positional inference depends crucially on morphogen spatial correlations and on
the "structural prior" that encodes the geometry of the cellular lattice performing
the readout, thereby determining what a cell can reliably assume about the position
of its neighbors when interpreting nonlocal morphogen signals. We derive upper
bounds on positional information gain due to nonlocal readout and identify signal
processing algorithms that approximate optimal positional inference, as well as
simple chemical reaction schemes which implement such algorithms. Our theory suggests
that correlational information can be exploited to significantly enhance developmental
precision.
acknowledgement: "This work was supported in part\r\nby European Research Council
No. ERC-2023-SyG\r\n“DynaTrans” Grant No. 101118866 (G. T.). We thank\r\nPieter
Rein ten Wolde and Vahe Galstyan for stimulating\r\ndiscussions."
article_number: '038401'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Chen Y
full_name: Zhang, Chen Y
id: 81b43fb8-c9d5-11ef-bf68-ade532a1f204
last_name: Zhang
- first_name: Pablo
full_name: Mateu Hoyos, Pablo
id: 50b236c7-50c1-11ef-bb9a-a2375694f8b5
last_name: Mateu Hoyos
- first_name: David
full_name: Brückner, David
id: e1e86031-6537-11eb-953a-f7ab92be508d
last_name: Brückner
orcid: 0000-0001-7205-2975
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
citation:
ama: Zhang CY, Mateu Hoyos P, Brückner D, Tkačik G. Nonlocal decoding of positional
and correlational information during development. Physical Review Letters.
2026;137. doi:10.1103/mbjk-v4ym
apa: Zhang, C. Y., Mateu Hoyos, P., Brückner, D., & Tkačik, G. (2026). Nonlocal
decoding of positional and correlational information during development. Physical
Review Letters. American Physical Society. https://doi.org/10.1103/mbjk-v4ym
chicago: Zhang, Chen Y, Pablo Mateu Hoyos, David Brückner, and Gašper Tkačik. “Nonlocal
Decoding of Positional and Correlational Information during Development.” Physical
Review Letters. American Physical Society, 2026. https://doi.org/10.1103/mbjk-v4ym.
ieee: C. Y. Zhang, P. Mateu Hoyos, D. Brückner, and G. Tkačik, “Nonlocal decoding
of positional and correlational information during development,” Physical Review
Letters, vol. 137. American Physical Society, 2026.
ista: Zhang CY, Mateu Hoyos P, Brückner D, Tkačik G. 2026. Nonlocal decoding of
positional and correlational information during development. Physical Review Letters.
137, 038401.
mla: Zhang, Chen Y., et al. “Nonlocal Decoding of Positional and Correlational Information
during Development.” Physical Review Letters, vol. 137, 038401, American
Physical Society, 2026, doi:10.1103/mbjk-v4ym.
short: C.Y. Zhang, P. Mateu Hoyos, D. Brückner, G. Tkačik, Physical Review Letters
137 (2026).
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: "Code to evaluate PI, to run algorithmic implementations
of ALP and RLP decoding, and to\r\nperform simulations is publicly available at
https://github.com/alex-chenyi-zhang/nonlocdec_pici."
date_created: 2026-07-14T05:38:28Z
date_published: 2026-07-15T00:00:00Z
date_updated: 2026-07-16T09:58:04Z
day: '15'
ddc:
- '530'
department:
- _id: GaTk
- _id: EdHa
- _id: GradSch
doi: 10.1103/mbjk-v4ym
file:
- access_level: open_access
checksum: 28861d31d0f6cf541aaca04faaed1767
content_type: application/pdf
creator: dernst
date_created: 2026-07-16T09:54:55Z
date_updated: 2026-07-16T09:54:55Z
file_id: '22352'
file_name: 2026_PhysicalReviewLetters_Zhang.pdf
file_size: 2550345
relation: main_file
success: 1
file_date_updated: 2026-07-16T09:54:55Z
has_accepted_license: '1'
intvolume: ' 137'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 7bfe6a29-9f16-11ee-852c-c0da5e2045d9
grant_number: '101118866'
name: 'Transcription in 4D: the dynamic interplay between chromatin architecture
and gene expression in developing pseudo-embryos'
publication: Physical Review Letters
publication_identifier:
eissn:
- ' 1079-7114'
issn:
- 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Nonlocal decoding of positional and correlational information during development
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 137
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '22333'
abstract:
- lang: eng
text: RNA polymerase II (Pol II) must be assembled in the cytoplasm before it enters
the nucleus, where it transcribes protein-coding genes. Although transcription
by Pol II is intensively studied, how this central multi-subunit enzyme is made
and the role of dedicated assembly factors remains unclear. Here, we report the
integrative structural analysis of a native human Pol II from the cytoplasm captured
near the end of biogenesis. The complex contains Gdown1 and three biogenesis factors
– RPAP2 and the critical small GTPases GPN1 and GPN3. Cryo-EM analysis of the
complex reveals how Gdown1 and RPAP2 associate with Pol II and prevent the premature
association of transcription factors. Further biochemical and cryo-EM analysis
reveals how RPAP2 tethers GPN1–GPN3 to the complex and how the assembly of the
RPAP2–GPN1–GPN3 complex is controlled by GTP hydrolysis. The combined results
uncover a network of interactions that chaperone cytoplasmic Pol II to prevent
aberrant interactions, reveal a molecular switch regulating biogenesis factor
association, and suggest a general mechanism for the action of GPN-loop GTPase
family of enzymes.
acknowledged_ssus:
- _id: LifeSc
- _id: EM-Fac
- _id: ScienComp
- _id: PreCl
acknowledgement: We thank A. Salmazo for assistance with Pol II purification. We thank
staff at the Vienna BioCenter Core Facilities (VBCF) Proteomics facility for immunoprecipitation-mass
spectrometry analysis, and J.A. Stopp for assistance with IP-MS data visualization.
This research was further supported by the Scientific Service Units (SSUs) of ISTA
through resources provided by the Lab Support Facility (LSF), Electron Microscopy
Facility (EMF), Scientific Computing (SciComp), and the Preclinical Facility (PCF).
F.H. was funded by the Endowed Professorship of the Lower Austria Research Funding
Agency (GFF NÖ) and by the Austrian Research Promotion Agency (FFG) through the
COIN Establishment Grant n.o. 45624401.
article_processing_charge: Yes
article_type: original
author:
- first_name: Annamaria
full_name: Hlavata, Annamaria
id: 36062FEC-F248-11E8-B48F-1D18A9856A87
last_name: Hlavata
- first_name: Benjamin
full_name: Neuditschko, Benjamin
last_name: Neuditschko
- first_name: Ulla
full_name: Schellhaas, Ulla
last_name: Schellhaas
- first_name: Clemens
full_name: Plaschka, Clemens
last_name: Plaschka
- first_name: Franz
full_name: Herzog, Franz
last_name: Herzog
- first_name: Carrie A
full_name: Bernecky, Carrie A
id: 2CB9DFE2-F248-11E8-B48F-1D18A9856A87
last_name: Bernecky
orcid: 0000-0003-0893-7036
biorxivid: 1
citation:
ama: Hlavata A, Neuditschko B, Schellhaas U, Plaschka C, Herzog F, Bernecky C. Structure
of cytoplasmic RNA polymerase II. Nature Communications. 2026. doi:10.1038/s41467-026-75416-8
apa: Hlavata, A., Neuditschko, B., Schellhaas, U., Plaschka, C., Herzog, F., &
Bernecky, C. (2026). Structure of cytoplasmic RNA polymerase II. Nature Communications.
Springer Nature. https://doi.org/10.1038/s41467-026-75416-8
chicago: Hlavata, Annamaria, Benjamin Neuditschko, Ulla Schellhaas, Clemens Plaschka,
Franz Herzog, and Carrie Bernecky. “Structure of Cytoplasmic RNA Polymerase II.”
Nature Communications. Springer Nature, 2026. https://doi.org/10.1038/s41467-026-75416-8.
ieee: A. Hlavata, B. Neuditschko, U. Schellhaas, C. Plaschka, F. Herzog, and C.
Bernecky, “Structure of cytoplasmic RNA polymerase II,” Nature Communications.
Springer Nature, 2026.
ista: Hlavata A, Neuditschko B, Schellhaas U, Plaschka C, Herzog F, Bernecky C.
2026. Structure of cytoplasmic RNA polymerase II. Nature Communications.
mla: Hlavata, Annamaria, et al. “Structure of Cytoplasmic RNA Polymerase II.” Nature
Communications, Springer Nature, 2026, doi:10.1038/s41467-026-75416-8.
short: A. Hlavata, B. Neuditschko, U. Schellhaas, C. Plaschka, F. Herzog, C. Bernecky,
Nature Communications (2026).
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: "The\r\nc ryo EM maps generated in this study were deposited
to the EM Data Bank under the\r\naccession codes: EMD 55583 [https://www.ebi.ac.uk/pdbe/entry/emdb/EMD
55583\r\n(Pol II Gdown1 RPAP2 composite map), EMD 55578\r\n[https://www.ebi.ac.uk/pdbe/entry/emdb/EMD
55578 Pol II Gdown1 RPAP2 Pol II core\r\nmap EMD 55579 [https://www.ebi.ac.uk/pdbe/entry/emdb/EMD
55579 Pol II\r\nGdown1 RPAP2 Pol II stalk map EMD 55580\r\n[https://www.ebi.ac.uk/pdbe/entry/emdb/EMD
55580 Pol II Gdown1 RPAP2 RPAP2\r\nmap EMD 55581 [https://www.ebi.ac.uk/pdbe/entry/emdb/EMD
55 581 Pol II\r\nGdown1 RPAP2 Gdown1 N terminus map EMD 55582\r\n[https://www.ebi.ac.uk/pdbe/entry/emdb/EMD
55582 Pol II Gdown1 RPAP2 Gdown1\r\nC terminus map and EMD 55585 [https://www.ebi.ac.uk/pdbe/entry/emdb/EMD\r\n55585
RPAP2 GPN1 GPN3 map Model coordi nates were deposited to the PDBe under\r\nthe accession
codes: 9T5H [http://doi.org/10.2210/pdb 9T5H / (Pol II Gdown1\r\nRPAP2 complex structure)
and 9T5J [http://doi.org/10.2210/pdb 9T5H / (GPN1\r\nGPN3 RPAP2 structure). Immunoprecipitation
mass spectrometry and crosslinking mass\r\nspectrometry proteomics data have been
deposited to the ProteomeXchange Consortium\r\nvia the PRIDE partner repository
with the dataset identifiers PXD071638\r\n[http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD
071638 and\r\nP XD070852\r\n[http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD
070852\r\nAlphaFold3 structure predictions have been deposited to the Zenodo repository\r\nhttps://doi.org/10.5281/zenodo.20687910
P reviously published model coordinates\r\nwere utilized and are available at the
PDB under the accession codes 8QEP\r\n[http://doi.org/10.2210/pdb 8QEP / 9BZ 0 [http://doi.org/10.2210/pdb
9BZ 0 /\r\nand 7B7U [http://doi.org/10.2210/pdb 7B7U / Source Data are provided
with this\r\npaper."
date_created: 2026-07-14T07:27:59Z
date_published: 2026-07-13T00:00:00Z
date_updated: 2026-07-16T11:29:31Z
day: '13'
ddc:
- '570'
department:
- _id: CaBe
doi: 10.1038/s41467-026-75416-8
external_id:
biorxivid:
- 10.64898/2025.12.10.692585
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41467-026-75416-8
month: '07'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Structure of cytoplasmic RNA polymerase II
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21777'
abstract:
- lang: eng
text: The advantageous characteristics attributed to the 19F nucleus have made it
a popular target for nuclear magnetic resonance (NMR) once again in recent years.
Aside from solution NMR, an increasing number of studies have been conducted applying
solid-state magic-angle spinning (MAS) NMR to fluorine-labelled samples. Here,
the high chemical shift anisotropy and strong dipolar couplings can be utilised
to get structural insights into proteins and measure long distances. Despite increasing
popularity and promising benefits, the sensitivity of biomolecular 19F MAS NMR
often suffers from slow longitudinal T1 relaxation and therefore long recycle
delays. In this work, we expand paramagnetic doping, an approach commonly used
to reduce proton T1 relaxation times, to 19F-labelled biological samples. We study
the effect of Gd(DTPA) and Gd(DTPA-BMA) on 19F T1 and T2, and 13C T1 and T2 relaxation
in a [5-19F13C]-tryptophan-labelled protein via 19F-detected MAS NMR experiments.
The observed paramagnetic relaxation enhancement substantially reduces measurement
times of 19F MAS NMR experiments without compromising resolution. Additionally,
we report the chemical shift assignments of all four fluorotryptophan signals
in the 12×39 kDa-large protein TET2 using a mutagenesis approach.
acknowledged_ssus:
- _id: NMR
- _id: LifeSc
acknowledgement: We thank Ben P. Tatman for insightful discussions. This research
was supported by the Scientific Service Units (SSUs) of ISTA through resources provided
by the Nuclear Magnetic Resonance Facility and the Lab Support Facility. We thank
Prof. Tobias Madl (Medical University Graz) for a sample of Omniscan. Lea M. Becker
is the recipient of a DOC fellowship of the Austrian Academy of Sciences at the
Institute of Science and Technology Austria (grant no. PR10660EAW01).
article_processing_charge: Yes
article_type: original
author:
- first_name: Lea Marie
full_name: Becker, Lea Marie
id: 36336939-eb97-11eb-a6c2-c83f1214ca79
last_name: Becker
orcid: 0000-0002-6401-5151
- first_name: Giorgia
full_name: Toscano, Giorgia
id: 334a5e40-8747-11f0-b671-ba1f5154b4b4
last_name: Toscano
- first_name: Anna
full_name: Kapitonova, Anna
id: 9fb2a840-89e1-11ee-a8b7-cc5c7ba62471
last_name: Kapitonova
- first_name: Rajkumar
full_name: Singh, Rajkumar
id: a3089acd-6806-11ee-bacc-f0c7d500ad20
last_name: Singh
- first_name: Undina
full_name: Guillerm, Undina
id: bb74f472-ae54-11eb-9835-bc9c22fb1183
last_name: Guillerm
- first_name: Roman J.
full_name: Lichtenecker, Roman J.
last_name: Lichtenecker
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
citation:
ama: Becker LM, Toscano G, Kapitonova A, et al. Accelerated 19F biomolecular magic-angle
spinning NMR with paramagnetic dopants. Magnetic Resonance. 2026;7(1):29-37.
doi:10.5194/mr-7-29-2026
apa: Becker, L. M., Toscano, G., Kapitonova, A., Singh, R., Guillerm, U., Lichtenecker,
R. J., & Schanda, P. (2026). Accelerated 19F biomolecular magic-angle spinning
NMR with paramagnetic dopants. Magnetic Resonance. Copernicus Publications.
https://doi.org/10.5194/mr-7-29-2026
chicago: Becker, Lea Marie, Giorgia Toscano, Anna Kapitonova, Rajkumar Singh, Undina
Guillerm, Roman J. Lichtenecker, and Paul Schanda. “Accelerated 19F Biomolecular
Magic-Angle Spinning NMR with Paramagnetic Dopants.” Magnetic Resonance.
Copernicus Publications, 2026. https://doi.org/10.5194/mr-7-29-2026.
ieee: L. M. Becker et al., “Accelerated 19F biomolecular magic-angle spinning
NMR with paramagnetic dopants,” Magnetic Resonance, vol. 7, no. 1. Copernicus
Publications, pp. 29–37, 2026.
ista: Becker LM, Toscano G, Kapitonova A, Singh R, Guillerm U, Lichtenecker RJ,
Schanda P. 2026. Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic
dopants. Magnetic Resonance. 7(1), 29–37.
mla: Becker, Lea Marie, et al. “Accelerated 19F Biomolecular Magic-Angle Spinning
NMR with Paramagnetic Dopants.” Magnetic Resonance, vol. 7, no. 1, Copernicus
Publications, 2026, pp. 29–37, doi:10.5194/mr-7-29-2026.
short: L.M. Becker, G. Toscano, A. Kapitonova, R. Singh, U. Guillerm, R.J. Lichtenecker,
P. Schanda, Magnetic Resonance 7 (2026) 29–37.
corr_author: '1'
date_created: 2026-05-03T22:01:36Z
date_published: 2026-04-16T00:00:00Z
date_updated: 2026-07-20T09:49:12Z
day: '16'
ddc:
- '540'
department:
- _id: PaSc
- _id: GradSch
doi: 10.5194/mr-7-29-2026
external_id:
pmid:
- '42057802'
has_accepted_license: '1'
intvolume: ' 7'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.5194/mr-7-29-2026
month: '04'
oa: 1
oa_version: Published Version
page: 29-37
pmid: 1
project:
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
- _id: 7be609c4-9f16-11ee-852c-85015ce2b9b0
grant_number: '26777'
name: Exploring protein dynamics by solid-state MAS NMR through specific labeling
approaches
publication: Magnetic Resonance
publication_identifier:
eissn:
- 2699-0016
publication_status: published
publisher: Copernicus Publications
quality_controlled: '1'
related_material:
record:
- id: '22334'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '22359'
abstract:
- lang: eng
text: We prove a mesoscopic central limit theorem for linear eigenvalue statistics
of correlated Hermitian random matrices. The class considered here includes Wigner
and Wigner-type matrices, as well as models whose entry correlations decay polynomially
in the distance between index pairs. The proof combines a multivariate cumulant
expansion with multi-resolvent local laws and a detailed analysis of the resulting
variance kernel on the operator-level.
acknowledgement: Supported by ERC Advanced Grant “RMTBeyond” No. 101020331
article_number: '2607.05848'
article_processing_charge: No
arxiv: 1
author:
- first_name: Jaehun
full_name: Lee, Jaehun
id: 96155047-f36a-11ef-b766-8b5ae7cecd49
last_name: Lee
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: Lee J, Erdös L. Mesoscopic eigenvalue statistics for correlated random matrices.
doi:10.48550/arXiv.2607.05848
apa: Lee, J., & Erdös, L. (n.d.). Mesoscopic eigenvalue statistics for correlated
random matrices. https://doi.org/10.48550/arXiv.2607.05848
chicago: Lee, Jaehun, and László Erdös. “Mesoscopic Eigenvalue Statistics for Correlated
Random Matrices,” n.d. https://doi.org/10.48550/arXiv.2607.05848.
ieee: J. Lee and L. Erdös, “Mesoscopic eigenvalue statistics for correlated random
matrices.” .
ista: Lee J, Erdös L. Mesoscopic eigenvalue statistics for correlated random matrices.
2607.05848.
mla: Lee, Jaehun, and László Erdös. Mesoscopic Eigenvalue Statistics for Correlated
Random Matrices. 2607.05848, doi:10.48550/arXiv.2607.05848.
short: J. Lee, L. Erdös, (n.d.).
corr_author: '1'
das_tickbox: '1'
date_created: 2026-07-18T08:59:02Z
date_published: 2026-07-07T00:00:00Z
date_updated: 2026-07-20T10:55:10Z
day: '07'
department:
- _id: LaEr
doi: 10.48550/arXiv.2607.05848
ec_funded: 1
external_id:
arxiv:
- '2607.05848'
keyword:
- Central limit theorem
- universality
- matrix Dyson equation
- multi-resolvent local law
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2607.05848
month: '07'
oa: 1
oa_version: Preprint
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
call_identifier: H2020
grant_number: '101020331'
name: Random matrices beyond Wigner-Dyson-Mehta
publication_status: submitted
status: public
title: Mesoscopic eigenvalue statistics for correlated random matrices
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '22360'
abstract:
- lang: eng
text: "In this paper, we consider the rectangular random matrix\r\nX =(xij ) ∈ RN×n
whose entries are iid with tail P(|xij | >\r\nt) ∼ t−α for some α> 0. We consider
the regime N(n)/n →\r\na > 1 as n tends to infinity. Our main interest lies in
the right\r\nsingular vector corresponding to the smallest singular value,\r\nwhich
we will refer to as the ``bottom singular vector'', denoted\r\nby \U0001D532.
In this paper, we prove the following phase transition\r\nregarding the localization
length of \U0001D532: when α< 2 the\r\nlocalization length is O(n/ log n); when
α> 2 the localization\r\nlength is of order n. Similar results hold for all right
singular\r\nvectors around the smallest singular value. The variational\r\ndefinition
of the bottom singular vector suggests that the\r\nmechanism for this localization-delocalization
transition when\r\nα goes across 2 is intrinsically different from the one for
the\r\ntop singular vector when α goes across 4"
article_number: '111266'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Zhigang
full_name: Bao, Zhigang
last_name: Bao
- first_name: Jaehun
full_name: Lee, Jaehun
id: 96155047-f36a-11ef-b766-8b5ae7cecd49
last_name: Lee
- first_name: Xiaocong
full_name: Xu, Xiaocong
last_name: Xu
citation:
ama: Bao Z, Lee J, Xu X. Phase transition for the bottom singular vector of rectangular
random matrices. Journal of Functional Analysis. 2026;290(4). doi:10.1016/j.jfa.2025.111266
apa: Bao, Z., Lee, J., & Xu, X. (2026). Phase transition for the bottom singular
vector of rectangular random matrices. Journal of Functional Analysis.
Elsevier. https://doi.org/10.1016/j.jfa.2025.111266
chicago: Bao, Zhigang, Jaehun Lee, and Xiaocong Xu. “Phase Transition for the Bottom
Singular Vector of Rectangular Random Matrices.” Journal of Functional Analysis.
Elsevier, 2026. https://doi.org/10.1016/j.jfa.2025.111266.
ieee: Z. Bao, J. Lee, and X. Xu, “Phase transition for the bottom singular vector
of rectangular random matrices,” Journal of Functional Analysis, vol. 290,
no. 4. Elsevier, 2026.
ista: Bao Z, Lee J, Xu X. 2026. Phase transition for the bottom singular vector
of rectangular random matrices. Journal of Functional Analysis. 290(4), 111266.
mla: Bao, Zhigang, et al. “Phase Transition for the Bottom Singular Vector of Rectangular
Random Matrices.” Journal of Functional Analysis, vol. 290, no. 4, 111266,
Elsevier, 2026, doi:10.1016/j.jfa.2025.111266.
short: Z. Bao, J. Lee, X. Xu, Journal of Functional Analysis 290 (2026).
date_created: 2026-07-18T10:32:41Z
date_published: 2026-02-15T00:00:00Z
date_updated: 2026-07-20T11:01:15Z
day: '15'
doi: 10.1016/j.jfa.2025.111266
extern: '1'
external_id:
arxiv:
- '2409.01819'
intvolume: ' 290'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2409.01819
month: '02'
oa: 1
oa_version: Preprint
publication: Journal of Functional Analysis
publication_identifier:
eissn:
- 1096-0783
issn:
- 0022-1236
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Phase transition for the bottom singular vector of rectangular random matrices
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 290
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '22362'
abstract:
- lang: eng
text: "We present a systematic study of the environments of 25 luminous quasars
at z > 6.5 from the ASPIRE program.\r\nUsing JWST/NIRCam wide-field slitless spectroscopy
data, we identified 487 galaxies at 5.3 ≲ z ≲ 7.0 exhibiting\r\n[O III] emission.
Among these, 122 [O III] emitters lie within |Δvlos| < 1000 km s\r\n−1 of the
quasars, corresponding\r\nto a ∼9.4-fold enhancement relative to the average galaxy
density at other redshifts. Furthermore, we identified 16\r\n[C II]-emitting galaxies
at the quasar redshifts from Atacama Large Millimeter/submillimeter Array (ALMA)
mosaic observations. A cross-correlation function analysis between quasars and
[O III]+[C II] emitters yields a\r\ncross-correlation length of r 8.68 h cMpc
0\r\nQG\r\n0.55 = +0.51 1\r\nand an autocorrelation of r 15.76 h cMpc 0\r\nQQ\r\n2.70
= +2.48 1 ,\r\nindicating that z ∼ 7 quasars reside in dark matter halos with\r\nMhalo
1012.27 0.26 M 0.21\r\n= +\r\nand have a quasar lifetime of\r\ntQ 10 yr 7.05 1.01\r\n0.95\r\n=
+\r\n. Notably, the number of [O III]-emitting galaxies at quasar redshifts varies
significantly from\r\nfield to field, ranging from 0 to 20, highlighting a diverse
quasar environment. Remarkably, seven quasars trace\r\nsignificant galaxy overdensities
(i.e., protoclusters), with δgal > 5 within a volume of V ∼ 500 cMpc3\r\n. We
also\r\nfind that |Δvlos| increases rapidly toward smaller galaxy–quasar separations
in protocluster fields, consistent with\r\ngalaxy kinematics around extremely
massive halos in cosmological simulations. By combining JWST and ALMA\r\ndata,
we reveal the complex and diverse environments of these early quasars, providing
robust evidence that the\r\nearliest luminous quasars are effective tracers of
galaxy overdensities, albeit with substantial field-to-field\r\nvariation."
acknowledgement: "F.W. acknowledges support from NSF award AST-2513040. J.B.C. acknowledges
funding from the JWST Arizona/Steward Postdoc in Early galaxies and Reionization
(JASPER) Scholar contract at the University of Arizona. M.H. acknowledges support
from the Swiss SNSF Starting Grant (grant no. 218032). S.E.I.B. is supported by
the Deutsche Forschungsgemeinschaft (DFG) under Emmy Noether grant No. BO 5771/1-1.
J.-T.S. is supported by the Deutsche Forschungsgemeinschaft (DFG, German Research
Foundation)—project No. 518006966. A.L. acknowledges support from PRIN MUR 2022935STW.
C.M. acknowledges support from Fondecyt Iniciacion grant 11240336 and the ANID BASAL
project FB210003. R.A.M. acknowledges support from the Swiss National Science Foundation
(SNSF) through project grant 200020_207349. B.T. acknowledges support from the European
Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
program (grant agreement No. 950533) and from the Excellence Cluster ORIGINS, which
is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
under Germany’s Excellence Strategy—EXC 2094—390783311. M.V. gratefully acknowledges
financial support from the Independent Research Fund Denmark via grant Nos. DFF
8021-00130 and 3103-00146 and from the Carlsberg Foundation (grant CF23-0417).\r\n\r\nThis
work is based on observations made with the NASA/ESA/CSA James Webb Space Telescope.
The data were obtained from the Mikulski Archive for Space Telescopes at the Space
Telescope Science Institute, which is operated by the Association of Universities
for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These
observations are associated with program #2078 and can be accessed via doi:10.17909/vt74-kd84.
Support for program #2078 was provided by NASA through a grant from the Space Telescope
Science Institute, which is operated by the Association of Universities for Research
in Astronomy, Inc., under NASA contract NAS 5-03127. We acknowledge the strong support
provided by the program coordinator Weston Eck and instrument reviewers Norbert
Pirzkal and Stephanie La Massa."
article_number: '39'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Feige
full_name: Wang, Feige
last_name: Wang
- first_name: Jaclyn B.
full_name: Champagne, Jaclyn B.
last_name: Champagne
- first_name: Jiamu
full_name: Huang, Jiamu
last_name: Huang
- first_name: Jinyi
full_name: Yang, Jinyi
last_name: Yang
- first_name: Joseph F.
full_name: Hennawi, Joseph F.
last_name: Hennawi
- first_name: Xiaohui
full_name: Fan, Xiaohui
last_name: Fan
- first_name: Haowen
full_name: Zhang, Haowen
last_name: Zhang
- first_name: Tiago
full_name: Costa, Tiago
last_name: Costa
- first_name: Roberto
full_name: Decarli, Roberto
last_name: Decarli
- first_name: Melanie
full_name: Habouzit, Melanie
last_name: Habouzit
- first_name: Fengwu
full_name: Sun, Fengwu
last_name: Sun
- first_name: Eduardo
full_name: Bañados, Eduardo
last_name: Bañados
- first_name: Xiangyu
full_name: Jin, Xiangyu
last_name: Jin
- first_name: Koki
full_name: Kakiichi, Koki
last_name: Kakiichi
- first_name: Romain A.
full_name: Meyer, Romain A.
last_name: Meyer
- first_name: Yunjing
full_name: Wu, Yunjing
last_name: Wu
- first_name: Silvia
full_name: Belladitta, Silvia
last_name: Belladitta
- first_name: Laura
full_name: Blecha, Laura
last_name: Blecha
- first_name: Sarah E.I.
full_name: Bosman, Sarah E.I.
last_name: Bosman
- first_name: Zheng
full_name: Cai, Zheng
last_name: Cai
- first_name: Thomas
full_name: Connor, Thomas
last_name: Connor
- first_name: Frederick B.
full_name: Davies, Frederick B.
last_name: Davies
- first_name: Anna Christina
full_name: Eilers, Anna Christina
last_name: Eilers
- first_name: Zoltán
full_name: Haiman, Zoltán
id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
last_name: Haiman
orcid: 0000-0003-3633-5403
- first_name: Hyunsung D.
full_name: Jun, Hyunsung D.
last_name: Jun
- first_name: Mingyu
full_name: Li, Mingyu
last_name: Li
- first_name: Zihao
full_name: Li, Zihao
last_name: Li
- first_name: Weizhe
full_name: Liu, Weizhe
last_name: Liu
- first_name: Alessandro
full_name: Lupi, Alessandro
last_name: Lupi
- first_name: Jianwei
full_name: Lyu, Jianwei
last_name: Lyu
- first_name: Chiara
full_name: Mazzucchelli, Chiara
last_name: Mazzucchelli
- first_name: Masafusa
full_name: Onoue, Masafusa
last_name: Onoue
- first_name: Elia
full_name: Pizzati, Elia
last_name: Pizzati
- first_name: Maria
full_name: Pudoka, Maria
last_name: Pudoka
- first_name: Sofía
full_name: Rojas-Ruiz, Sofía
last_name: Rojas-Ruiz
- first_name: Jan Torge
full_name: Schindler, Jan Torge
last_name: Schindler
- first_name: Yue
full_name: Shen, Yue
last_name: Shen
- first_name: Wei Leong
full_name: Tee, Wei Leong
last_name: Tee
- first_name: Benny
full_name: Trakhtenbrot, Benny
last_name: Trakhtenbrot
- first_name: Maxime
full_name: Trebitsch, Maxime
last_name: Trebitsch
- first_name: Marianne
full_name: Vestergaard, Marianne
last_name: Vestergaard
- first_name: Marta
full_name: Volonteri, Marta
last_name: Volonteri
- first_name: Fabian
full_name: Walter, Fabian
last_name: Walter
- first_name: Huanian
full_name: Zhang, Huanian
last_name: Zhang
- first_name: Siwei
full_name: Zou, Siwei
last_name: Zou
citation:
ama: 'Wang F, Champagne JB, Huang J, et al. ASPIRE: The environments and dark matter
halos of luminous quasars in the epoch of reionization. Astrophysical Journal.
2026;1006(1). doi:10.3847/1538-4357/ae7bfa'
apa: 'Wang, F., Champagne, J. B., Huang, J., Yang, J., Hennawi, J. F., Fan, X.,
… Zou, S. (2026). ASPIRE: The environments and dark matter halos of luminous quasars
in the epoch of reionization. Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ae7bfa'
chicago: 'Wang, Feige, Jaclyn B. Champagne, Jiamu Huang, Jinyi Yang, Joseph F. Hennawi,
Xiaohui Fan, Haowen Zhang, et al. “ASPIRE: The Environments and Dark Matter Halos
of Luminous Quasars in the Epoch of Reionization.” Astrophysical Journal.
IOP Publishing, 2026. https://doi.org/10.3847/1538-4357/ae7bfa.'
ieee: 'F. Wang et al., “ASPIRE: The environments and dark matter halos of
luminous quasars in the epoch of reionization,” Astrophysical Journal,
vol. 1006, no. 1. IOP Publishing, 2026.'
ista: 'Wang F, Champagne JB, Huang J, Yang J, Hennawi JF, Fan X, Zhang H, Costa
T, Decarli R, Habouzit M, Sun F, Bañados E, Jin X, Kakiichi K, Meyer RA, Wu Y,
Belladitta S, Blecha L, Bosman SEI, Cai Z, Connor T, Davies FB, Eilers AC, Haiman
Z, Jun HD, Li M, Li Z, Liu W, Lupi A, Lyu J, Mazzucchelli C, Onoue M, Pizzati
E, Pudoka M, Rojas-Ruiz S, Schindler JT, Shen Y, Tee WL, Trakhtenbrot B, Trebitsch
M, Vestergaard M, Volonteri M, Walter F, Zhang H, Zou S. 2026. ASPIRE: The environments
and dark matter halos of luminous quasars in the epoch of reionization. Astrophysical
Journal. 1006(1), 39.'
mla: 'Wang, Feige, et al. “ASPIRE: The Environments and Dark Matter Halos of Luminous
Quasars in the Epoch of Reionization.” Astrophysical Journal, vol. 1006,
no. 1, 39, IOP Publishing, 2026, doi:10.3847/1538-4357/ae7bfa.'
short: F. Wang, J.B. Champagne, J. Huang, J. Yang, J.F. Hennawi, X. Fan, H. Zhang,
T. Costa, R. Decarli, M. Habouzit, F. Sun, E. Bañados, X. Jin, K. Kakiichi, R.A.
Meyer, Y. Wu, S. Belladitta, L. Blecha, S.E.I. Bosman, Z. Cai, T. Connor, F.B.
Davies, A.C. Eilers, Z. Haiman, H.D. Jun, M. Li, Z. Li, W. Liu, A. Lupi, J. Lyu,
C. Mazzucchelli, M. Onoue, E. Pizzati, M. Pudoka, S. Rojas-Ruiz, J.T. Schindler,
Y. Shen, W.L. Tee, B. Trakhtenbrot, M. Trebitsch, M. Vestergaard, M. Volonteri,
F. Walter, H. Zhang, S. Zou, Astrophysical Journal 1006 (2026).
das_tickbox: '1'
dataavailabilitystatement: "This paper makes use of the following ALMA data: ADS/JAO.ALMA#2022.1.01077.L.
ALMA is a partnership of ESO (representing its member states), NSF (USA) and NINS
(Japan), together with NRC (Canada), MOST and ASIAA (Taiwan), and KASI (Republic
of Korea), in cooperation with the Republic of Chile. The Joint ALMA Observatory
is operated by ESO, AUI/NRAO and NAOJ. The National Radio Astronomy Observatory
is a facility of the National Science Foundation operated under cooperative agreement
by Associated Universities, Inc.\r\n\r\nFacility: JWST - James Webb Space Telescope
(NIRCam).\r\n\r\nSoftware: astropy (Astropy Collaboration et al. 2018), Matplotlib
(J. D. Hunter 2007), Numpy (C. R. Harris et al. 2020), Photutils (L. Bradley et
al. 2022), Scipy (P. Virtanen et al. 2020), Source Extractor (E. Bertin & S. Arnouts
1996)."
date_created: 2026-07-19T22:01:46Z
date_published: 2026-07-20T00:00:00Z
date_updated: 2026-07-20T13:31:18Z
day: '20'
ddc:
- '520'
department:
- _id: ZoHa
doi: 10.3847/1538-4357/ae7bfa
external_id:
arxiv:
- '2602.04979'
file:
- access_level: open_access
checksum: dd561fc00841217c227687e42d499ff0
content_type: application/pdf
creator: dernst
date_created: 2026-07-20T13:19:42Z
date_updated: 2026-07-20T13:19:42Z
file_id: '22377'
file_name: 2026_AstrophysicalJour_Wang.pdf
file_size: 6884305
relation: main_file
success: 1
file_date_updated: 2026-07-20T13:19:42Z
has_accepted_license: '1'
intvolume: ' 1006'
issue: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
publication: Astrophysical Journal
publication_identifier:
eissn:
- '15384357'
issn:
- 0004637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: 'ASPIRE: The environments and dark matter halos of luminous quasars in the
epoch of reionization'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1006
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '22364'
abstract:
- lang: eng
text: Finding the first generation of (Population III or Pop III) stars is one of
the most ambitious and exciting challenges of astrophysics. JWST opened concrete
prospects for their detection during the Epoch of Reionization, where increasing
evidence suggests that residual Pop III formation may persist, even within pristine
pockets of high-mass halos, due to inhomogeneous enrichment. However, the identification
of Pop III stars within globally enriched environments will be challenging. We
investigate the detectability of a subdominant Pop III component in/around massive
(M⋆ ≳ 10^9 M⊙) galaxies at z ≈ 6.5–9 from the dustyGadget cosmological simulation
suite, and the confusion arising from second-generation (Pop II) stars in their
surroundings. We find that young (≲1 Myr), massive (MIII ∼ 6 × 10^5 M⊙) Pop III
clusters forming within these galaxy environments are responsible for strong HeII1640
line emission (LHeII1640 ≳ 10^41 erg ^s−1), which would be detectable with ≈10(50)
hr of medium-resolution observations with NIRSpec/IFU at z ≈ 6(10). These bright
luminosities cannot be produced by standard Pop II populations alone. On the other
hand, the dominant Pop II component within massive “hybrid” Pop III hosts powers
strong metal line emission (L[OIII]5007 ≳ 10^42 erg s^−1), indicating that the
detection of metal lines alone cannot exclude the presence of Pop IIIs in high-z
galaxy environments. We further discuss candidate selection strategies based on
Lyα, Hα, and Hβ emission, and how spatially resolved observations may enable the
detection of isolated, pristine pockets in the outskirts of massive halos.
acknowledgement: We thank Elka Rusta and Stefania Salvadori for providing predictions
of the He II line luminosities from the NEFERTITI model. A.V. acknowledges funding
from the Cosmic Frontier Center and the University of Texas at Austin’s College
of Natural Sciences. A.V., L.G., and R.S. acknowledge support from the PRIN 2022
MUR project 2022CB3PJ3—First Light And Galaxy aSsembly (FLAGS) funded by the European
Union—Next Generation EU. J.B.M. was supported by NSF Grants AST-2307354 and AST-2408637,
and by the NSF-Simons AI Institute for Cosmic Origins. This research was also supported
in part by grant NSF PHY-2309135 to the Kavli Institute for Theoretical Physics
(KITP). R.V. acknowledges support from PRIN MUR “2022935STW” funded by European
Union-Next Generation EU, Missione 4 Componente 2 CUP C53D23000950006 and from Bando
Ricerca Fondamentale INAF 2023, Theory Grant “Theoretical models for Black Holes
Archaeology." C.D.C. acknowledges support from the European Union (ERC, AGENTS,
101076224).
article_number: '226'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Alessandra
full_name: Venditti, Alessandra
last_name: Venditti
- first_name: Luca
full_name: Graziani, Luca
last_name: Graziani
- first_name: Raffaella
full_name: Schneider, Raffaella
last_name: Schneider
- first_name: Volker
full_name: Bromm, Volker
last_name: Bromm
- first_name: Julian B.
full_name: Muñoz, Julian B.
last_name: Muñoz
- first_name: Claudia
full_name: Di Cesare, Claudia
id: 2d002343-372f-11ef-98ec-a164d20427cb
last_name: Di Cesare
- first_name: Rosa
full_name: Valiante, Rosa
last_name: Valiante
- first_name: Antonello
full_name: Calabrò, Antonello
last_name: Calabrò
- first_name: Roberto
full_name: Maiolino, Roberto
last_name: Maiolino
- first_name: Steven L.
full_name: Finkelstein, Steven L.
last_name: Finkelstein
- first_name: Massimiliano
full_name: Parente, Massimiliano
last_name: Parente
- first_name: Matteo
full_name: Saggini, Matteo
last_name: Saggini
- first_name: John
full_name: Chisholm, John
last_name: Chisholm
citation:
ama: 'Venditti A, Graziani L, Schneider R, et al. Catching the nebular needle in
a polluted haystack: Line-emission signatures from population III-forming pockets
around massive galaxies at the end of reionization. The Astrophysical Journal.
2026;1005(2). doi:10.3847/1538-4357/ae7b2c'
apa: 'Venditti, A., Graziani, L., Schneider, R., Bromm, V., Muñoz, J. B., Di Cesare,
C., … Chisholm, J. (2026). Catching the nebular needle in a polluted haystack:
Line-emission signatures from population III-forming pockets around massive galaxies
at the end of reionization. The Astrophysical Journal. IOP Publishing.
https://doi.org/10.3847/1538-4357/ae7b2c'
chicago: 'Venditti, Alessandra, Luca Graziani, Raffaella Schneider, Volker Bromm,
Julian B. Muñoz, Claudia Di Cesare, Rosa Valiante, et al. “Catching the Nebular
Needle in a Polluted Haystack: Line-Emission Signatures from Population III-Forming
Pockets around Massive Galaxies at the End of Reionization.” The Astrophysical
Journal. IOP Publishing, 2026. https://doi.org/10.3847/1538-4357/ae7b2c.'
ieee: 'A. Venditti et al., “Catching the nebular needle in a polluted haystack:
Line-emission signatures from population III-forming pockets around massive galaxies
at the end of reionization,” The Astrophysical Journal, vol. 1005, no.
2. IOP Publishing, 2026.'
ista: 'Venditti A, Graziani L, Schneider R, Bromm V, Muñoz JB, Di Cesare C, Valiante
R, Calabrò A, Maiolino R, Finkelstein SL, Parente M, Saggini M, Chisholm J. 2026.
Catching the nebular needle in a polluted haystack: Line-emission signatures from
population III-forming pockets around massive galaxies at the end of reionization.
The Astrophysical Journal. 1005(2), 226.'
mla: 'Venditti, Alessandra, et al. “Catching the Nebular Needle in a Polluted Haystack:
Line-Emission Signatures from Population III-Forming Pockets around Massive Galaxies
at the End of Reionization.” The Astrophysical Journal, vol. 1005, no.
2, 226, IOP Publishing, 2026, doi:10.3847/1538-4357/ae7b2c.'
short: A. Venditti, L. Graziani, R. Schneider, V. Bromm, J.B. Muñoz, C. Di Cesare,
R. Valiante, A. Calabrò, R. Maiolino, S.L. Finkelstein, M. Parente, M. Saggini,
J. Chisholm, The Astrophysical Journal 1005 (2026).
das_tickbox: '1'
dataavailabilitystatement: 'Software: dustyGadget (L. Graziani et al. 2020), BPASSv2.2.134
(J. J. Eldridge et al. 2017; E. R. Stanway & J. J. Eldridge 2018), Yggdrasil35 (E.
Zackrisson et al. 2011), Cloudy22.0136 (G. J. Ferland et al. 2017), NumPy37 (S.
van der Walt et al. 2011; C. R. Harris et al. 2020), matplotlib38 (J. D. Hunter
2007), SciPy39 (Jones et al. 2001; P. Virtanen et al. 2020).'
date_created: 2026-07-19T22:01:46Z
date_published: 2026-07-10T00:00:00Z
date_updated: 2026-07-20T13:07:08Z
day: '10'
ddc:
- '520'
department:
- _id: JoMa
doi: 10.3847/1538-4357/ae7b2c
external_id:
arxiv:
- '2603.27582'
file:
- access_level: open_access
checksum: e783c9c10cf773482ac2f3b340ad130b
content_type: application/pdf
creator: dernst
date_created: 2026-07-20T13:05:27Z
date_updated: 2026-07-20T13:05:27Z
file_id: '22375'
file_name: 2026_AstrophysicalJour_Venditti.pdf
file_size: 2267572
relation: main_file
success: 1
file_date_updated: 2026-07-20T13:05:27Z
has_accepted_license: '1'
intvolume: ' 1005'
issue: '2'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: bd9b2118-d553-11ed-ba76-db24564edfea
grant_number: '101076224'
name: Young galaxies as tracers and agents of cosmic reionization
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: 'Catching the nebular needle in a polluted haystack: Line-emission signatures
from population III-forming pockets around massive galaxies at the end of reionization'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1005
year: '2026'
...
---
OA_place: publisher
OA_type: diamond
PlanS_conform: '1'
_id: '22369'
abstract:
- lang: eng
text: The high-redshift progenitors of present-day galaxy clusters are believed
to substantially contribute to the global star formation rate density and drive
the large-scale reionisation of the Universe. Here we present a blind and unbiased
search for and characterisation of galaxy overdensities during the reionisation
epoch at redshifts z ∼ 5.5 − 7 based on rest-frame optical JWST/NIRCam grism spectroscopy
of the Abell 2744 lensing field as part of the JWST All the Little Things (ALT)
survey. Using a physically motivated, cosmological inference friends-of-friends
(FoF) algorithm, we identified six galaxy overdensities, including five robust
systems at z = 5.66–6.77. They are all characterised by total halo masses of Mhalo ≳ 1011 M⊙,
inferred from a range of proxies. We find that the galaxy members in these overdense
environments are on average less massive though equally metal-rich, and generally
comprised of younger stellar populations, as indicated by their bluer spectral
slopes and less prominent Balmer breaks compared to field galaxies at similar
redshifts. Further, we use this novel rest-frame optical selection of galaxy proto-clusters
to infer the fraction and 3D distribution of strong Lyman-α emitters (LAEs) and
damped Lyman-α absorbers (DLAs) in the overdensity environments. We find that
two out of the six galaxy overdensities have excess H I absorption compared to
the field average, while the other four are consistent within their large scatter
in density. These results present the first direct observational constraints on
the tomography of the dense, neutral gas reservoirs in large-scale galaxy overdensities
at z > 5 and highlight the limitations of pre-JWST searches for reionisation-era
galaxy overdensities relying on the detection of strong LAEs alone.
acknowledgement: 'We would like to thank the anonymous referee for their positive
and constructive report and all the observers world-wide for their substantial effort
in securing all the public JWST data that were essential for this work. The Cosmic
Dawn Center (DAWN) is funded by the Danish National Research Foundation under grant
DNRF140. KEH acknowledges support from the Independent Research Fund Denmark (DFF)
under grant 5251-00009B and co-funding by the European Union (ERC, HEAVYMETAL, 101071865).
Views and opinions expressed are, however, those of the authors only and do not
necessarily reflect those of the European Union or the European Research Council.
Neither the European Union nor the granting authority can be held responsible for
them. This work is based in part on observations made with the NASA/ESA/CSA James
Webb Space Telescope. The data were obtained from the Mikulski Archive for Space
Telescopes (MAST) at the Space Telescope Science Institute, which is operated by
the Association of Universities for Research in Astronomy, Inc., under NASA contract
NAS 5-03127 for JWST. We used the following software for this work: Python, and
the scientific Python ecosystem, in particular NumPy (Harris et al. 2020), SciPy
(including cKDTree) (Virtanen et al. 2021), Matplotlib (Hunter 2007), and Astropy
(Astropy Collaboration 2013, 2018, 2022).'
article_number: A290
article_processing_charge: No
article_type: original
author:
- first_name: Chamilla
full_name: Terp, Chamilla
last_name: Terp
- first_name: Kasper E.
full_name: Heintz, Kasper E.
last_name: Heintz
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Rohan P.
full_name: Naidu, Rohan P.
last_name: Naidu
- first_name: Pascal A.
full_name: Oesch, Pascal A.
last_name: Oesch
- first_name: Callum
full_name: Witten, Callum
last_name: Witten
- first_name: Daichi
full_name: Kashino, Daichi
last_name: Kashino
- first_name: Clara L.
full_name: Pollock, Clara L.
last_name: Pollock
- first_name: Claudia
full_name: Di Cesare, Claudia
id: 2d002343-372f-11ef-98ec-a164d20427cb
last_name: Di Cesare
- first_name: Alberto
full_name: Torralba Torregrosa, Alberto
id: 018f0249-0e87-11f0-b167-cbce08fbd541
last_name: Torralba Torregrosa
orcid: 0000-0001-5586-6950
citation:
ama: 'Terp C, Heintz KE, Matthee JJ, et al. All the massive galaxy overdensities
during reionisation: JWST rest-frame optical selection reveals young, chemically
evolved galaxies embedded in dense, neutral gas at z > 5. Astronomy &
Astrophysics. 2026;710. doi:10.1051/0004-6361/202659436'
apa: 'Terp, C., Heintz, K. E., Matthee, J. J., Naidu, R. P., Oesch, P. A., Witten,
C., … Torralba Torregrosa, A. (2026). All the massive galaxy overdensities during
reionisation: JWST rest-frame optical selection reveals young, chemically evolved
galaxies embedded in dense, neutral gas at z > 5. Astronomy & Astrophysics.
EDP Sciences. https://doi.org/10.1051/0004-6361/202659436'
chicago: 'Terp, Chamilla, Kasper E. Heintz, Jorryt J Matthee, Rohan P. Naidu, Pascal
A. Oesch, Callum Witten, Daichi Kashino, Clara L. Pollock, Claudia Di Cesare,
and Alberto Torralba Torregrosa. “All the Massive Galaxy Overdensities during
Reionisation: JWST Rest-Frame Optical Selection Reveals Young, Chemically Evolved
Galaxies Embedded in Dense, Neutral Gas at z > 5.” Astronomy & Astrophysics.
EDP Sciences, 2026. https://doi.org/10.1051/0004-6361/202659436.'
ieee: 'C. Terp et al., “All the massive galaxy overdensities during reionisation:
JWST rest-frame optical selection reveals young, chemically evolved galaxies embedded
in dense, neutral gas at z > 5,” Astronomy & Astrophysics, vol.
710. EDP Sciences, 2026.'
ista: 'Terp C, Heintz KE, Matthee JJ, Naidu RP, Oesch PA, Witten C, Kashino D, Pollock
CL, Di Cesare C, Torralba Torregrosa A. 2026. All the massive galaxy overdensities
during reionisation: JWST rest-frame optical selection reveals young, chemically
evolved galaxies embedded in dense, neutral gas at z > 5. Astronomy &
Astrophysics. 710, A290.'
mla: 'Terp, Chamilla, et al. “All the Massive Galaxy Overdensities during Reionisation:
JWST Rest-Frame Optical Selection Reveals Young, Chemically Evolved Galaxies Embedded
in Dense, Neutral Gas at z > 5.” Astronomy & Astrophysics, vol.
710, A290, EDP Sciences, 2026, doi:10.1051/0004-6361/202659436.'
short: C. Terp, K.E. Heintz, J.J. Matthee, R.P. Naidu, P.A. Oesch, C. Witten, D.
Kashino, C.L. Pollock, C. Di Cesare, A. Torralba Torregrosa, Astronomy & Astrophysics
710 (2026).
das_tickbox: '1'
dataavailabilitystatement: The specific observations analysed in this work can be
accessed via https://doi.org/10.5281/zenodo.13871850
date_created: 2026-07-19T22:01:47Z
date_published: 2026-06-01T00:00:00Z
date_updated: 2026-07-20T13:42:20Z
day: '01'
ddc:
- '520'
department:
- _id: JoMa
doi: 10.1051/0004-6361/202659436
file:
- access_level: open_access
checksum: 0a63db666cfac8e4e6271b75419a26f2
content_type: application/pdf
creator: dernst
date_created: 2026-07-20T13:41:19Z
date_updated: 2026-07-20T13:41:19Z
file_id: '22378'
file_name: 2026_AstronomyAstrophysics_Terp.pdf
file_size: 6156048
relation: main_file
success: 1
file_date_updated: 2026-07-20T13:41:19Z
has_accepted_license: '1'
intvolume: ' 710'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
publication: Astronomy & Astrophysics
publication_identifier:
eissn:
- 1432-0746
issn:
- 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: 'All the massive galaxy overdensities during reionisation: JWST rest-frame
optical selection reveals young, chemically evolved galaxies embedded in dense,
neutral gas at z > 5'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 710
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22361'
abstract:
- lang: eng
text: Causal optimal transport and adapted Wasserstein distance have applications
in different fields from optimization to mathematical finance and machine learning.
The goal of this article is to provide equivalent formulations of these concepts
in classic probabilistic language. In particular, we prove a Skorokhod representation
theorem for adapted weak convergence, reformulate the equivalence of stochastic
processes using Markovian lifts, and give an expression for the adapted Wasserstein
distance based on representing processes on a common stochastic basis.
acknowledgement: 'This research was funded in whole or in part by the Austrian Science
Fund (FWF) [doi: 10.55776/P34743, 10.55776/Y782, 10.55776/P35197 and 10.55776/J4981].
For open access purposes, the author has applied a CC BY public copyright license
to any author accepted manuscript version arising from this submission.'
article_number: '105032'
article_processing_charge: Yes (in subscription journal)
article_type: original
arxiv: 1
author:
- first_name: Mathias
full_name: Beiglböck, Mathias
last_name: Beiglböck
- first_name: Susanne
full_name: Pflügl, Susanne
id: 8da18bd3-8437-11f1-a311-c814b8b76424
last_name: Pflügl
- first_name: Stefan
full_name: Schrott, Stefan
last_name: Schrott
citation:
ama: Beiglböck M, Pflügl S, Schrott S. A probabilistic view on the adapted Wasserstein
distance. Stochastic Processes and their Applications. 2026;201. doi:10.1016/j.spa.2026.105032
apa: Beiglböck, M., Pflügl, S., & Schrott, S. (2026). A probabilistic view on
the adapted Wasserstein distance. Stochastic Processes and Their Applications.
Elsevier. https://doi.org/10.1016/j.spa.2026.105032
chicago: Beiglböck, Mathias, Susanne Pflügl, and Stefan Schrott. “A Probabilistic
View on the Adapted Wasserstein Distance.” Stochastic Processes and Their Applications.
Elsevier, 2026. https://doi.org/10.1016/j.spa.2026.105032.
ieee: M. Beiglböck, S. Pflügl, and S. Schrott, “A probabilistic view on the adapted
Wasserstein distance,” Stochastic Processes and their Applications, vol.
201. Elsevier, 2026.
ista: Beiglböck M, Pflügl S, Schrott S. 2026. A probabilistic view on the adapted
Wasserstein distance. Stochastic Processes and their Applications. 201, 105032.
mla: Beiglböck, Mathias, et al. “A Probabilistic View on the Adapted Wasserstein
Distance.” Stochastic Processes and Their Applications, vol. 201, 105032,
Elsevier, 2026, doi:10.1016/j.spa.2026.105032.
short: M. Beiglböck, S. Pflügl, S. Schrott, Stochastic Processes and Their Applications
201 (2026).
das_tickbox: '1'
date_created: 2026-07-19T22:01:45Z
date_published: 2026-07-10T00:00:00Z
date_updated: 2026-07-20T12:46:53Z
day: '10'
ddc:
- '500'
department:
- _id: JaMa
doi: 10.1016/j.spa.2026.105032
external_id:
arxiv:
- '2406.19810'
has_accepted_license: '1'
intvolume: ' 201'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.spa.2026.105032
month: '07'
oa: 1
oa_version: Published Version
publication: Stochastic Processes and their Applications
publication_identifier:
issn:
- 0304-4149
publication_status: epub_ahead
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: A probabilistic view on the adapted Wasserstein distance
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 201
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22372'
abstract:
- lang: eng
text: Neurons acquire polarity by specifying one neurite as the axon, whereas the
others become dendrites. But how this fundamental asymmetry is established remains
unclear1. Neuronal polarization has been thought to rely primarily on growth cones
that sense external cues2. Here we show that growth cones alone do not direct
this process and that the soma acts as a central organizer of neuronal polarization.
Using live imaging and genetic loss-of-function approaches in vivo, combined with
optogenetic control and local cytoskeletal perturbations in cultured neurons,
we uncover a soma-initiated oscillatory program that primes axon selection. Periodic
actin branching that depends on the actin-related protein 2/3 (ARP2/3) complex
at the soma remodels a global actomyosin network, thereby generating an actin
wave that retracts neurites before propagating into a single neurite tip. Exposure
to this wave relaxes local actomyosin contractility, which drives a transient
microtubule-based protrusion and biases this neurite towards axon fate. As the
cell exits this oscillatory stage, this neurite can overcome global inhibition
and extend independently of ARP2/3, whereas actomyosin activity suppresses axon
formation in the remaining neurites so that they subsequently become dendrites.
This soma-driven mechanism ensures the emergence of a single axon independent
of environmental cues and underpins the unidirectional information flow in neuronal
circuits.
acknowledgement: 'We thank O. Gruss, E. Handley, H. Herzel, A. Kania, A. Koseska,
E. Kiermaier, D. Manstein, C. Niessen, K. Rottner, J. Schiweck, G. Tavosanis, D. Wachten,
R. Wedlich-Söldner and W. Witke for critically reading and discussing the manuscript;
C. Günter and V. Štimac for feedback on data presentation; B. Randel, J. Benner,
L. Meyn and A.-T. Pham for technical assistance; L. M. Neußer, K. Herz, K. Van-De-Kamp
and M. Diwo for their support on mice maintenance; H. Fried, I. Koenig, S. Filser
and Y. Fu for their technical support on experimental setup; and M. Aghabeig for
writing the Fiji macro scripts. C.H.C. was a Human Frontier Science Program Long-term
Postdoctoral Fellow (LT000100/2013). F.B. is supported by the Deutsches Zentrum
für Neurodegenerative Erkrankungen (DZNE), the International Foundation for Research
in Paraplegia, Wings for Life, ERANET AXON REPAIR, ERANET RATER SCI and the Chan–Zuckerberg
Initiative (CZI). F.B. is also funded by the Deutsche Forschungsgemeinschaft (DFG,
German Research Foundation)–Project-ID 227953431–SFB 1089, SFB 1690 as well as SFB
1158 and SPP 2395. F.B. is a member of the excellence cluster ImmunoSensation2 (EXC2151–390873048)
and the iBehave NRW network. F.B. is a recipient of the Roger de Spoelberch Prize.
F.K.M.S. acknowledges support from Austrian Science Fund (FWF): P33367. A.N. is
supported by JSPS KAKENHI (grant numbers 18H02410 and 21H02440). Open access funding
provided by Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) in
der Helmholtz-Gemeinschaft.'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Tien Chen
full_name: Lin, Tien Chen
last_name: Lin
- first_name: Charlotte H.
full_name: Coles, Charlotte H.
last_name: Coles
- first_name: Eissa
full_name: Alfadil, Eissa
last_name: Alfadil
- first_name: Florian
full_name: Fäßler, Florian
id: 404F5528-F248-11E8-B48F-1D18A9856A87
last_name: Fäßler
orcid: 0000-0001-7149-769X
- first_name: Andreas
full_name: Husch, Andreas
last_name: Husch
- first_name: Sebastian
full_name: Dupraz, Sebastian
last_name: Dupraz
- first_name: Thorben
full_name: Pietralla, Thorben
last_name: Pietralla
- first_name: Akihiro
full_name: Narita, Akihiro
last_name: Narita
- first_name: Max
full_name: Schelski, Max
last_name: Schelski
- first_name: Kevin C.
full_name: Flynn, Kevin C.
last_name: Flynn
- first_name: Sina
full_name: Stern, Sina
last_name: Stern
- first_name: Christoph
full_name: Möhl, Christoph
last_name: Möhl
- first_name: Brett J.
full_name: Hilton, Brett J.
last_name: Hilton
- first_name: Franz
full_name: Vauti, Franz
last_name: Vauti
- first_name: Hans Henning
full_name: Arnold, Hans Henning
last_name: Arnold
- first_name: Florian Km
full_name: Schur, Florian Km
id: 48AD8942-F248-11E8-B48F-1D18A9856A87
last_name: Schur
orcid: 0000-0003-4790-8078
- first_name: Frank
full_name: Bradke, Frank
last_name: Bradke
citation:
ama: Lin TC, Coles CH, Alfadil E, et al. An intrinsic cytoskeletal oscillator establishes
neuronal polarity. Nature. 2026. doi:10.1038/s41586-026-10755-6
apa: Lin, T. C., Coles, C. H., Alfadil, E., Fäßler, F., Husch, A., Dupraz, S., …
Bradke, F. (2026). An intrinsic cytoskeletal oscillator establishes neuronal polarity.
Nature. Springer Nature. https://doi.org/10.1038/s41586-026-10755-6
chicago: Lin, Tien Chen, Charlotte H. Coles, Eissa Alfadil, Florian Fäßler, Andreas
Husch, Sebastian Dupraz, Thorben Pietralla, et al. “An Intrinsic Cytoskeletal
Oscillator Establishes Neuronal Polarity.” Nature. Springer Nature, 2026.
https://doi.org/10.1038/s41586-026-10755-6.
ieee: T. C. Lin et al., “An intrinsic cytoskeletal oscillator establishes
neuronal polarity,” Nature. Springer Nature, 2026.
ista: Lin TC, Coles CH, Alfadil E, Fäßler F, Husch A, Dupraz S, Pietralla T, Narita
A, Schelski M, Flynn KC, Stern S, Möhl C, Hilton BJ, Vauti F, Arnold HH, Schur
FK, Bradke F. 2026. An intrinsic cytoskeletal oscillator establishes neuronal
polarity. Nature.
mla: Lin, Tien Chen, et al. “An Intrinsic Cytoskeletal Oscillator Establishes Neuronal
Polarity.” Nature, Springer Nature, 2026, doi:10.1038/s41586-026-10755-6.
short: T.C. Lin, C.H. Coles, E. Alfadil, F. Fäßler, A. Husch, S. Dupraz, T. Pietralla,
A. Narita, M. Schelski, K.C. Flynn, S. Stern, C. Möhl, B.J. Hilton, F. Vauti,
H.H. Arnold, F.K. Schur, F. Bradke, Nature (2026).
das_tickbox: '1'
dataavailabilitystatement: The raw data of the representative images have been deposited
into Zenodo (https://doi.org/10.5281/zenodo.20118606)99. Owing to the large file
size of the raw image data and the processed data used in the analyses that generated
the graphs, we archived the image files in the read-only file archive at the DZNE
institute. We provide raw data files upon request. The request can be directed to
and will be fulfilled by the lead contact F.B. Source data are provided with this
paper. The custom ImageJ macro used for generating kymographs, extracting neurite
tip positions and protein intensities is available at GitHub (https://github.com/darkbreaker0/IJ_NeuriteGrowthScript)
and Zenodo (https://doi.org/10.5281/zenodo.20118606)99. The custom R and Python
scripts used in the study are available at GitHub (https://github.com/darkbreaker0/Arp3_neuronal_polarization_2026)
and Zenodo (https://doi.org/10.5281/zenodo.20118606)99. The code used for polarity
determination of the actin filament in tomograms is available at Zenodo (https://doi.org/10.5281/zenodo.20081075)93.
date_created: 2026-07-19T22:01:48Z
date_published: 2026-07-08T00:00:00Z
date_updated: 2026-07-20T14:18:10Z
day: '08'
ddc:
- '570'
department:
- _id: FlSc
doi: 10.1038/s41586-026-10755-6
external_id:
pmid:
- '42420447'
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41586-026-10755-6
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 9B954C5C-BA93-11EA-9121-9846C619BF3A
grant_number: P33367
name: Structure and isoform diversity of the Arp2/3 complex
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: An intrinsic cytoskeletal oscillator establishes neuronal polarity
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
_id: '22255'
abstract:
- lang: eng
text: "This thesis studies spectral rigidity and nonrigidity phenomena in dynamical
systems. The central question is whether a dynamical system can be determined,
up to a natural conjugacy, from its spectrum. We consider three related spectra:
the length spectrum, the action spectrum, and the Lyapunov spectrum.\r\n\r\nThe
first part of the thesis concerns Liouville metrics on the two-dimensional torus.
It is a long-standing folklore conjecture that Liouville metrics are the only
integrable metrics on the torus. We prove a length-spectral rigidity result for
linear conformal deformations of Liouville metrics by exploiting the dynamical
properties of the rational tori -- analogues of the resonant convex caustics in
billiards. We also establish a complementary classification result showing that
marked-length-isospectral Liouville metrics are characterized by rearrangements
of the one-dimensional functions appearing in their conformal factors, generalizing
a theorem of Abbondandolo-Mazzucchelli. In particular, the second result gives
nonrigidity examples within the class of Liouville metrics.\r\n\r\nThe second
part of the thesis studies the standard map from the viewpoint of action and Lyapunov
spectra. We construct nontrivial deformations of the standard map which preserve
the symplectic actions (respectively, the Lyapunov exponents) of infinitely many
periodic orbits accumulating on an invariant curve. The proof combines a resonant
normal form construction with Picard iteration schemes to obtain a sequence of
periodic orbits accumulating on an invariant curve with a Liouville rotation number.
Within the resonant normal forms we capture the dependence of these periodic orbits
on the resonant Fourier coefficients of the dynamics on the invariant curve and,
using the contraction mapping principle, obtain a suitable deformation achieving
the prescribed spectral data associated with this sequence of orbits. The result
can be viewed as a symplectic twist-map analogue of a length-spectral nonrigidity
phenomenon for Riemannian manifolds and convex billiards, and it motivates the
existence problem for similar 'partially length-isospectral' deformations of strictly
convex billiard tables.\r\n"
acknowledged_ssus:
- _id: E-Lib
- _id: CampIT
acknowledgement: "The financial support of the ERC grant SPERIG #885707 is gratefully
acknowledged.\r\n"
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Yunzhe
full_name: Li, Yunzhe
id: 41cb05d3-f128-11eb-9611-e4e2b3cfba31
last_name: Li
citation:
ama: Li Y. Spectral rigidity and nonrigidity of dynamical systems. 2026. doi:10.15479/AT-ISTA-22255
apa: Li, Y. (2026). Spectral rigidity and nonrigidity of dynamical systems.
Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-22255
chicago: Li, Yunzhe. “Spectral Rigidity and Nonrigidity of Dynamical Systems.” Institute
of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-22255.
ieee: Y. Li, “Spectral rigidity and nonrigidity of dynamical systems,” Institute
of Science and Technology Austria, 2026.
ista: Li Y. 2026. Spectral rigidity and nonrigidity of dynamical systems. Institute
of Science and Technology Austria.
mla: Li, Yunzhe. Spectral Rigidity and Nonrigidity of Dynamical Systems.
Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-22255.
short: Y. Li, Spectral Rigidity and Nonrigidity of Dynamical Systems, Institute
of Science and Technology Austria, 2026.
corr_author: '1'
date_created: 2026-07-08T12:44:31Z
date_published: 2026-07-11T00:00:00Z
date_updated: 2026-07-20T14:58:23Z
day: '11'
ddc:
- '515'
degree_awarded: PhD
department:
- _id: GradSch
- _id: VaKa
doi: 10.15479/AT-ISTA-22255
doi_confirm: '1'
ec_funded: 1
file:
- access_level: open_access
checksum: 8201cb5a427656a41828ecde8a85c04b
content_type: application/pdf
creator: yli
date_created: 2026-07-14T10:48:45Z
date_updated: 2026-07-14T10:48:45Z
file_id: '22337'
file_name: 2026_Li_Yunzhe_Thesis.pdf
file_size: 1260717
relation: main_file
- access_level: closed
checksum: 19ee8461ed77f5b7980fc9461f778b6f
content_type: application/x-zip-compressed
creator: yli
date_created: 2026-07-14T11:07:18Z
date_updated: 2026-07-20T14:00:33Z
file_id: '22339'
file_name: 2026_Li_Yunzhe_Thesis.zip
file_size: 418752
relation: source_file
file_date_updated: 2026-07-20T14:00:33Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '131'
project:
- _id: 9B8B92DE-BA93-11EA-9121-9846C619BF3A
call_identifier: H2020
grant_number: '885707'
name: Spectral rigidity and integrability for billiards and geodesic flows
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '22340'
relation: part_of_dissertation
status: public
- id: '22341'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
title: Spectral rigidity and nonrigidity of dynamical systems
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '22371'
abstract:
- lang: eng
text: Amoeboid cell migration is key to efficient T cell immunity. Spatial polarization
of organelles within cells, including endo-lysosomes, is a prerequisite of migration.
However, how ultrastructural polarization is linked to the signaling requirements
governing T cell migration remains unknown. Here we show that signaling molecules
generated by endo-lysosome-localized kinases regulate velocity of amoeboid migration.
Specifically, imaging of T cells identifies accumulation of endo-lysosomes decorated
with the lipid kinases VPS34–PIKfyve at the uropod of polarized cells. Activity
of VPS34 and PIKfyve regulates speed, but not directedness, of migrating T cells.
Mechanistically, PI(3,5)P2 generated by the sequential action of VPS34 and PIKfyve,
mediates Ca2+ efflux from lysosomes via the mucolipin TRP cation channel 1 (TRPML1),
thus controlling activity of myosin IIA and hence the generation of propulsive
force through retrograde actin flow. The VPS34–PIKfyve kinases also regulate velocity
of myeloid cells, as well as of the amoeba Dictyostelium discoideum – establishing
the axis as an evolutionarily conserved speed control system of amoeboid cell
migration.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: We thank the microscopy core facility of the Department of Biomedicine
at the University and University Hospital of Basel for their technical support.
This research was technically supported by the Scientific Service Units (SSU) of
ISTA through resources provided by the Imaging & Optics Facility (IOF) and the Lab
Support Facility (LSF). CH was supported by the Swiss National Science Foundation
(SNSF) (310030B_201277; 310030_192677; FZEB-0-180487), the ZBF Program Award 2025
(Hans Zäslin Bustany Foundation), and the Novartis Foundation for Medical-Biological
Research (NFMBR) (#23A070). PD was supported by the Swiss Academy for Medical Sciences
(SAMW) and SNSF (183980, 225441), the NFMBR (#23A070), AlumniMedizin Basel, and
the Freiwillige Akademische Gesellschaft Basel. DFL was supported by the SNSF (220205).
Open access funding provided by University of Basel.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Philippe G
full_name: Dehio, Philippe G
id: b769738e-a003-11ee-b1b8-9030316e0d59
last_name: Dehio
- first_name: Céline
full_name: Michard, Céline
last_name: Michard
- first_name: Juan Carlos
full_name: Yam-Puc, Juan Carlos
last_name: Yam-Puc
- first_name: Adrià Arnau
full_name: Martí I Líndez, Adrià Arnau
last_name: Martí I Líndez
- first_name: Anett
full_name: Jandke, Anett
last_name: Jandke
- first_name: Gunhild
full_name: Unterstab, Gunhild
last_name: Unterstab
- first_name: Lucien
full_name: Fabre, Lucien
last_name: Fabre
- first_name: Loïc
full_name: Sauteur, Loïc
last_name: Sauteur
- first_name: Marc
full_name: Artinger, Marc
last_name: Artinger
- first_name: Daniel F.
full_name: Legler, Daniel F.
last_name: Legler
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Thorsten
full_name: Schaefer, Thorsten
last_name: Schaefer
- first_name: Matthias P.
full_name: Wymann, Matthias P.
last_name: Wymann
- first_name: Klaus
full_name: Okkenhaug, Klaus
last_name: Okkenhaug
- first_name: Thierry
full_name: Soldati, Thierry
last_name: Soldati
- first_name: Matthias
full_name: Mehling, Matthias
id: 3C23B994-F248-11E8-B48F-1D18A9856A87
last_name: Mehling
orcid: 0000-0001-8599-1226
- first_name: Christoph
full_name: Hess, Christoph
last_name: Hess
citation:
ama: Dehio PG, Michard C, Yam-Puc JC, et al. A conserved VPS34-PIKfyve-TRPML1-myosin
II axis regulates the speed of amoeboid cell migration. EMBO Reports. 2026.
doi:10.1038/s44319-026-00861-x
apa: Dehio, P. G., Michard, C., Yam-Puc, J. C., Martí I Líndez, A. A., Jandke, A.,
Unterstab, G., … Hess, C. (2026). A conserved VPS34-PIKfyve-TRPML1-myosin II axis
regulates the speed of amoeboid cell migration. EMBO Reports. Springer
Nature. https://doi.org/10.1038/s44319-026-00861-x
chicago: Dehio, Philippe G, Céline Michard, Juan Carlos Yam-Puc, Adrià Arnau Martí
I Líndez, Anett Jandke, Gunhild Unterstab, Lucien Fabre, et al. “A Conserved VPS34-PIKfyve-TRPML1-Myosin
II Axis Regulates the Speed of Amoeboid Cell Migration.” EMBO Reports.
Springer Nature, 2026. https://doi.org/10.1038/s44319-026-00861-x.
ieee: P. G. Dehio et al., “A conserved VPS34-PIKfyve-TRPML1-myosin II axis
regulates the speed of amoeboid cell migration,” EMBO Reports. Springer
Nature, 2026.
ista: Dehio PG, Michard C, Yam-Puc JC, Martí I Líndez AA, Jandke A, Unterstab G,
Fabre L, Sauteur L, Artinger M, Legler DF, Sixt MK, Schaefer T, Wymann MP, Okkenhaug
K, Soldati T, Mehling M, Hess C. 2026. A conserved VPS34-PIKfyve-TRPML1-myosin
II axis regulates the speed of amoeboid cell migration. EMBO Reports.
mla: Dehio, Philippe G., et al. “A Conserved VPS34-PIKfyve-TRPML1-Myosin II Axis
Regulates the Speed of Amoeboid Cell Migration.” EMBO Reports, Springer
Nature, 2026, doi:10.1038/s44319-026-00861-x.
short: P.G. Dehio, C. Michard, J.C. Yam-Puc, A.A. Martí I Líndez, A. Jandke, G.
Unterstab, L. Fabre, L. Sauteur, M. Artinger, D.F. Legler, M.K. Sixt, T. Schaefer,
M.P. Wymann, K. Okkenhaug, T. Soldati, M. Mehling, C. Hess, EMBO Reports (2026).
das_tickbox: '1'
dataavailabilitystatement: "The analysis workflow to quantify vesicle localization
can be accessed on GitHub (https://github.com/loicsauteur/vesicle-analysis, version
0.1.1).\r\n\r\nThe source data of this paper are collected in the following database
record: biostudies:S-SCDT-10_1038-S44319-026-00861-x."
date_created: 2026-07-19T22:01:48Z
date_published: 2026-07-07T00:00:00Z
date_updated: 2026-07-20T14:28:59Z
day: '07'
department:
- _id: MiSi
doi: 10.1038/s44319-026-00861-x
external_id:
pmid:
- '42414599'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s44319-026-00861-x
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
publication: EMBO Reports
publication_identifier:
eissn:
- 1469-3178
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: A conserved VPS34-PIKfyve-TRPML1-myosin II axis regulates the speed of amoeboid
cell migration
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_type: closed access
_id: '22366'
abstract:
- lang: eng
text: Gravitropism is a fundamental adaptive response in plants that enables directional
growth to optimize resource acquisition. In this study, we employed forward genetic
screening to identify Arabidopsis mutants with defective hypocotyl gravitropism
and isolated the short and agravitropic hypocotyl in dark1 (sad1) mutant, which
carries a point mutation (G110E) in the SAC1 gene encoding a phosphoinositide
phosphatase. Deficiency of SAC1 disrupted gravity-induced polar localization of
PIN3 in endodermal cells, impairing auxin redistribution and leading to hypocotyl
gravitropism defects. Subcellular localization analysis revealed that SAC1 is
partially localized to the PVC/tonoplast and participates in late endosomal trafficking.
The sac1 mutation leads to abnormal vacuolar morphology, which is associated with
defects in amyloplast sedimentation during the gravitropic response in Arabidopsis
shoots. We further revealed that SAC1 interacts with GRV2, a key regulator of
the late endocytic pathway, and that both proteins cooperatively regulate shoot
gravitropism. In summary, this study identified SAC1 as a regulator of shoot gravitropism,
revealing its important role in modulating vacuolar homeostasis, amyloplast sedimentation,
PIN3 trafficking, and auxin distribution. These findings provide insights into
the molecular mechanisms linking membrane transport to environmental adaptation
in plants.
acknowledgement: We acknowledge Prof. Dolf Weijers (Wageningen University), Prof.Karin
Schumacher (Heidelberg University), Prof. Yohann Boutt ´e(Universit ´e de Bordeaux),
and Prof. Jinbo Shen (Zhejiang A&FUniversity) for providing published plasmids and
Arabidopsislines. We thank Dr. Gergely Moln ´ar (ISTA) for help with NGS dataanalysis,
and Prof. Jianru Zuo (IGDB, CAS), Prof. Chengbin Xiang(USTC), and Prof. Zhong Zhao
(USTC) for critical comments onthe manuscript. We thank the staff members of the
Mass Spec-trometry System at the National Facility for Protein Science inShanghai
(NFPS), Zhangjiang Lab, China for providing technicalsupport and assistance in data
collection and analysis. This workwas supported by grants from the National Natural
Science Foun-dation of China (32570366, and 32321001 to ST), the Natural Sci-ence
Foundation of Anhui Province (2508085QC070 to MK), theFundamental Research Funds
for the Central Universities(WK9100250095 to MK, and WK9100000021 to ST), the ForestryBureau
of Anhui Province (AHLYJBGS-2024-01 to ST), the Centerfor Advanced Interdisciplinary
Science and Biomedicine of IHM,Division of Life Sciences and Medicine, University
of Science andTechnology of China (QYPY20220012 to ST), the USTC ResearchFunds of
the Double First-Class Initiative (YD9100002016 to ST),and start-up funding from
the University of Science and Technol-ogy of China and the Chinese Academy of Sciences(GG9100007007,
KY9100000026, KY9100000051, XKTS-202591014,XKTS-2026910122, and KJ2070000079 to
ST).
article_number: e71042
article_processing_charge: No
article_type: original
author:
- first_name: Lianghanxiao
full_name: Sun, Lianghanxiao
last_name: Sun
- first_name: Wenxin
full_name: Jia, Wenxin
last_name: Jia
- first_name: Yanbo
full_name: Mao, Yanbo
last_name: Mao
- first_name: Xin
full_name: Li, Xin
last_name: Li
- first_name: Mengjuan
full_name: Kong, Mengjuan
last_name: Kong
- first_name: Ji
full_name: She, Ji
last_name: She
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Shutang
full_name: Tan, Shutang
id: 2DE75584-F248-11E8-B48F-1D18A9856A87
last_name: Tan
orcid: 0000-0002-0471-8285
citation:
ama: Sun L, Jia W, Mao Y, et al. Regulation of shoot gravitropism and branching
angle by the GRV2-SAC1 axis in Arabidopsis. The Plant Journal. 2026;127(1).
doi:10.1111/tpj.71042
apa: Sun, L., Jia, W., Mao, Y., Li, X., Kong, M., She, J., … Tan, S. (2026). Regulation
of shoot gravitropism and branching angle by the GRV2-SAC1 axis in Arabidopsis.
The Plant Journal. Wiley. https://doi.org/10.1111/tpj.71042
chicago: Sun, Lianghanxiao, Wenxin Jia, Yanbo Mao, Xin Li, Mengjuan Kong, Ji She,
Jiří Friml, and Shutang Tan. “Regulation of Shoot Gravitropism and Branching Angle
by the GRV2-SAC1 Axis in Arabidopsis.” The Plant Journal. Wiley, 2026.
https://doi.org/10.1111/tpj.71042.
ieee: L. Sun et al., “Regulation of shoot gravitropism and branching angle
by the GRV2-SAC1 axis in Arabidopsis,” The Plant Journal, vol. 127, no.
1. Wiley, 2026.
ista: Sun L, Jia W, Mao Y, Li X, Kong M, She J, Friml J, Tan S. 2026. Regulation
of shoot gravitropism and branching angle by the GRV2-SAC1 axis in Arabidopsis.
The Plant Journal. 127(1), e71042.
mla: Sun, Lianghanxiao, et al. “Regulation of Shoot Gravitropism and Branching Angle
by the GRV2-SAC1 Axis in Arabidopsis.” The Plant Journal, vol. 127, no.
1, e71042, Wiley, 2026, doi:10.1111/tpj.71042.
short: L. Sun, W. Jia, Y. Mao, X. Li, M. Kong, J. She, J. Friml, S. Tan, The Plant
Journal 127 (2026).
das_tickbox: '1'
dataavailabilitystatement: Biological materials (seeds, plasmids) are available upon
request from ST (sttan@ustc.edu.cn). The data that support the findings of this study
are available on request from the corresponding author. The data are not publicly
available due to privacy or ethical restrictions.
date_created: 2026-07-19T22:01:47Z
date_published: 2026-07-01T00:00:00Z
date_updated: 2026-07-20T13:53:44Z
day: '01'
department:
- _id: JiFr
doi: 10.1111/tpj.71042
external_id:
pmid:
- '42438075'
intvolume: ' 127'
issue: '1'
keyword:
- auxin
- SAC1
- GRV2
- PIN3
- vacuole
- gravitropism
- Arabidopsis
language:
- iso: eng
month: '07'
oa_version: None
pmid: 1
publication: The Plant Journal
publication_identifier:
eissn:
- 1365-313X
issn:
- 0960-7412
publication_status: published
publisher: Wiley
quality_controlled: '1'
researchdata_availability: upon request
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Regulation of shoot gravitropism and branching angle by the GRV2-SAC1 axis
in Arabidopsis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 127
year: '2026'
...
---
OA_place: publisher
OA_type: gold
_id: '22368'
abstract:
- lang: eng
text: "We study simple dynamics in the population protocol model, in\r\nwhich \U0001D45B
agents start with totally ordered initial opinions \U0001D4651, \U0001D4652, .
. . ,\r\n\U0001D465\U0001D45B and, in each round, a randomly chosen agent changes
its opinion\r\nas a function of the opinion of other randomly chosen agents. Such\r\ndynamics
often converge to consensus on a single fixation value \U0001D44Bˆ.\r\nThis paper
asks how to control the distribution of \U0001D44Bˆ as a randomised\r\nchoice
among the initial opinions by designing suitable simple\r\ndynamics. Writing the
sorted initial values as \U0001D465(1) ≤ · · · ≤ \U0001D465(\U0001D45B)\r\n,\r\nwe
design two protocols that realise natural target laws over order\r\nstatistics.\r\nFirst,
for a parameter \U0001D45D ∈ (0, 1), our geometric protocol biases\r\ntoward larger
opinions and satisfies P\r\n\r\n\U0001D44Bˆ = \U0001D465(\U0001D458)\r\n\r\n∝
\U0001D45D\r\n\U0001D45B−\U0001D458\r\n, for\r\n\U0001D458 = 1, . . . , \U0001D45B.
Equivalently, P\r\n\r\n\U0001D44Bˆ = \U0001D465(\U0001D458)\r\n\r\n= (1 − \U0001D45D)\U0001D45D\r\n\U0001D45B−\U0001D458\r\n/(1
− \U0001D45D\r\n\U0001D45B\r\n).\r\nSecond, our binomial protocol assigns a shifted
binomial law to the\r\nranks in ascending order: if \U0001D43E −1 ∼ Bin(\U0001D45B−1,
1−\U0001D45D), then \U0001D44Bˆ = \U0001D465(\U0001D43E)\r\n,\r\ni.e., P\r\n\r\n\U0001D44Bˆ
= \U0001D465(\U0001D458)\r\n\r\n=\r\n\U0001D45B−1\r\n\U0001D458−1\r\n\x01\r\n\U0001D45D\r\n\U0001D45B−\U0001D458\r\n(1
− \U0001D45D)\r\n\U0001D458−1\r\n, for \U0001D458 = 1, . . . , \U0001D45B.\r\nApplications
of this include computing the Top-\U0001D458 values for\r\nsmall \U0001D458 on
general interaction graphs. A central contribution of\r\nthis work is that, in
contrast to most population protocols, we can\r\ncharacterise the fixation distribution
in closed form. This is enabled\r\nby a novel analysis technique, which also yields
applications: we\r\nderive new results for the Median protocol that extend the
state of\r\nthe art."
acknowledgement: "This work has been supported by the AID INRIA-DGA project\r\nn°2023000872
“BioSwarm”, the French government National Research Agency (ANR) through the UCA
JEDI (ANR-15-IDEX-01),\r\nthe EUR DS4H (ANR-17-EURE-004) and the 3IA Cote d’Azur
Investments ANR-23-IACL-0001, and EPSRC grant EP/W005573/1"
article_processing_charge: No
author:
- first_name: Niccolò
full_name: D'Archivio, Niccolò
last_name: D'Archivio
- first_name: Hind
full_name: Almahmoud, Hind
last_name: Almahmoud
- first_name: Emanuele
full_name: Natale, Emanuele
last_name: Natale
- first_name: Frederik
full_name: Mallmann-Trenn, Frederik
id: 68748c44-84d5-11f1-b4f6-ca083374e553
last_name: Mallmann-Trenn
citation:
ama: 'D’Archivio N, Almahmoud H, Natale E, Mallmann-Trenn F. Order statistics in
population protocols via simple dynamics. In: Proceedings of the Annual ACM
Symposium on Principles of Distributed Computing. Association for Computing
Machinery; 2026:425-436. doi:10.1145/3796701.3815922'
apa: 'D’Archivio, N., Almahmoud, H., Natale, E., & Mallmann-Trenn, F. (2026).
Order statistics in population protocols via simple dynamics. In Proceedings
of the Annual ACM Symposium on Principles of Distributed Computing (pp. 425–436).
Egham, United Kingdom: Association for Computing Machinery. https://doi.org/10.1145/3796701.3815922'
chicago: D’Archivio, Niccolò, Hind Almahmoud, Emanuele Natale, and Frederik Mallmann-Trenn.
“Order Statistics in Population Protocols via Simple Dynamics.” In Proceedings
of the Annual ACM Symposium on Principles of Distributed Computing, 425–36.
Association for Computing Machinery, 2026. https://doi.org/10.1145/3796701.3815922.
ieee: N. D’Archivio, H. Almahmoud, E. Natale, and F. Mallmann-Trenn, “Order statistics
in population protocols via simple dynamics,” in Proceedings of the Annual
ACM Symposium on Principles of Distributed Computing, Egham, United Kingdom,
2026, pp. 425–436.
ista: 'D’Archivio N, Almahmoud H, Natale E, Mallmann-Trenn F. 2026. Order statistics
in population protocols via simple dynamics. Proceedings of the Annual ACM Symposium
on Principles of Distributed Computing. PODC: Symposium on Principles of Distributed
Computing, 425–436.'
mla: D’Archivio, Niccolò, et al. “Order Statistics in Population Protocols via Simple
Dynamics.” Proceedings of the Annual ACM Symposium on Principles of Distributed
Computing, Association for Computing Machinery, 2026, pp. 425–36, doi:10.1145/3796701.3815922.
short: N. D’Archivio, H. Almahmoud, E. Natale, F. Mallmann-Trenn, in:, Proceedings
of the Annual ACM Symposium on Principles of Distributed Computing, Association
for Computing Machinery, 2026, pp. 425–436.
conference:
end_date: 2026-07-10
location: Egham, United Kingdom
name: 'PODC: Symposium on Principles of Distributed Computing'
start_date: 2026-07-06
corr_author: '1'
das_tickbox: '0'
date_created: 2026-07-19T22:01:47Z
date_published: 2026-07-01T00:00:00Z
date_updated: 2026-07-21T07:34:49Z
day: '01'
ddc:
- '000'
department:
- _id: MoHe
doi: 10.1145/3796701.3815922
file:
- access_level: open_access
checksum: e8208393a016d8e71d7b26c402045488
content_type: application/pdf
creator: dernst
date_created: 2026-07-21T07:31:29Z
date_updated: 2026-07-21T07:31:29Z
file_id: '22379'
file_name: 2026_ACMPODC_dArchivio.pdf
file_size: 824239
relation: main_file
success: 1
file_date_updated: 2026-07-21T07:31:29Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 425-436
publication: Proceedings of the Annual ACM Symposium on Principles of Distributed
Computing
publication_identifier:
isbn:
- '9798400725128'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Order statistics in population protocols via simple dynamics
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: gold
_id: '22367'
abstract:
- lang: eng
text: "We study the Undecided-State Dynamics (USD), a fundamental consensus process
in which each vertex holds one of k decided opinions or the undecided state. We
consider both the gossip model and the population protocol model. Prior work established
tight bounds on the consensus time of this process only for the regime \r\nk\r\n=\r\nO\r\n(\r\nn\r\n/\r\n(\r\nlog\r\n\r\nn\r\n)\r\n2\r\n)\r\n
(for the population protocol model) and k = O((n/log n)1/3) (for the gossip model),
often under restrictive assumptions on the initial configuration.\r\nIn this paper,
we obtain the first consensus-time guarantees for USD that hold for arbitrary
2 ≤ k ≤ n and for arbitrary initial configurations in both the gossip model and
the population protocol model. In the gossip model, USD reaches consensus within
\r\nO\r\n~\r\n(\r\nmin\r\n{\r\nk\r\n,\r\nn\r\n}\r\n)\r\n synchronous rounds with
probability 1 - p⊥ - n-c, where p⊥ is the gossip-specific probability of collapsing
to the all-undecided state in the first round. In the population protocol model,
USD reaches consensus within \r\nO\r\n~\r\n(\r\nmin\r\n{\r\nk\r\nn\r\n,\r\nn\r\n3\r\n/\r\n2\r\n}\r\n)\r\n
asynchronous interactions with high probability. We also present lower bounds
that match the upper bounds up to polylogarithmic factors for a specific initial
configuration and show that our upper bounds are essentially optimal."
acknowledgement: "Nobutaka Shimizu is supported by JSPS KAKENHI Grant Number\r\n23K16837.
Takeharu Shiraga is supported by JSPS KAKENHI Grant\r\nNumber 23K16840, and JST
CRONOS Grant Number JPMJCS24K2.\r\nColin Cooper is supported by a Mercator Fellowship
from DFG\r\nProject 491453517 at the University of Hamburg. We thank the\r\nanonymous
reviewers for their helpful comments and suggestions."
article_processing_charge: No
arxiv: 1
author:
- first_name: Colin
full_name: Cooper, Colin
last_name: Cooper
- first_name: Frederik
full_name: Mallmann-Trenn, Frederik
id: 68748c44-84d5-11f1-b4f6-ca083374e553
last_name: Mallmann-Trenn
- first_name: Tomasz
full_name: Radzik, Tomasz
last_name: Radzik
- first_name: Nobutaka
full_name: Shimizu, Nobutaka
last_name: Shimizu
- first_name: Takeharu
full_name: Shiraga, Takeharu
last_name: Shiraga
citation:
ama: 'Cooper C, Mallmann-Trenn F, Radzik T, Shimizu N, Shiraga T. Undecided state
dynamics with many opinions. In: Proceedings of the Annual ACM Symposium on
Principles of Distributed Computing. Association for Computing Machinery;
2026:77-87. doi:10.1145/3796701.3815920'
apa: 'Cooper, C., Mallmann-Trenn, F., Radzik, T., Shimizu, N., & Shiraga, T.
(2026). Undecided state dynamics with many opinions. In Proceedings of the
Annual ACM Symposium on Principles of Distributed Computing (pp. 77–87). Egham,
United Kingdom: Association for Computing Machinery. https://doi.org/10.1145/3796701.3815920'
chicago: Cooper, Colin, Frederik Mallmann-Trenn, Tomasz Radzik, Nobutaka Shimizu,
and Takeharu Shiraga. “Undecided State Dynamics with Many Opinions.” In Proceedings
of the Annual ACM Symposium on Principles of Distributed Computing, 77–87.
Association for Computing Machinery, 2026. https://doi.org/10.1145/3796701.3815920.
ieee: C. Cooper, F. Mallmann-Trenn, T. Radzik, N. Shimizu, and T. Shiraga, “Undecided
state dynamics with many opinions,” in Proceedings of the Annual ACM Symposium
on Principles of Distributed Computing, Egham, United Kingdom, 2026, pp. 77–87.
ista: 'Cooper C, Mallmann-Trenn F, Radzik T, Shimizu N, Shiraga T. 2026. Undecided
state dynamics with many opinions. Proceedings of the Annual ACM Symposium on
Principles of Distributed Computing. PODC: Symposium on Principles of Distributed
Computing, 77–87.'
mla: Cooper, Colin, et al. “Undecided State Dynamics with Many Opinions.” Proceedings
of the Annual ACM Symposium on Principles of Distributed Computing, Association
for Computing Machinery, 2026, pp. 77–87, doi:10.1145/3796701.3815920.
short: C. Cooper, F. Mallmann-Trenn, T. Radzik, N. Shimizu, T. Shiraga, in:, Proceedings
of the Annual ACM Symposium on Principles of Distributed Computing, Association
for Computing Machinery, 2026, pp. 77–87.
conference:
end_date: 2026-07-10
location: Egham, United Kingdom
name: 'PODC: Symposium on Principles of Distributed Computing'
start_date: 2026-07-06
corr_author: '1'
das_tickbox: '1'
date_created: 2026-07-19T22:01:47Z
date_published: 2026-07-01T00:00:00Z
date_updated: 2026-07-21T07:54:01Z
day: '01'
ddc:
- '000'
department:
- _id: MoHe
doi: 10.1145/3796701.3815920
external_id:
arxiv:
- '2603.02636'
file:
- access_level: open_access
checksum: 9ada61feba1e93fd72867a5ba4ee8bb8
content_type: application/pdf
creator: dernst
date_created: 2026-07-21T07:51:58Z
date_updated: 2026-07-21T07:51:58Z
file_id: '22380'
file_name: 2026_ACMPODC_Cooper.pdf
file_size: 709077
relation: main_file
success: 1
file_date_updated: 2026-07-21T07:51:58Z
has_accepted_license: '1'
keyword:
- consensus dynamics
- undecided state dynamics
- gossip model
- population protocol model
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 77-87
publication: Proceedings of the Annual ACM Symposium on Principles of Distributed
Computing
publication_identifier:
isbn:
- '9798400725128'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Undecided state dynamics with many opinions
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '22370'
abstract:
- lang: eng
text: We report a unified method for the synthesis of α-polyhalomethyl amines from
alkenes and alkynes, enabled by readily available hemiaminal reagents. This operationally
simple transformation allows for the introduction of not only well-established
CF3 and CF2H groups, but also the synthetically (and medicinally) underexplored
CF2Cl and CFClH motifs—thereby broadening access to previously inaccessible chemical
space of halogenated amine scaffolds. The method displays broad substrate scope
and functional-group tolerance while operating under mild conditions. Late-stage
functionalization of drug-like derivatives of Oxaprozin, Erlotinib, and Ibuprofen
(among others) is reported.
acknowledgement: "Funded by the European Union (ERC, C-HANCE, 101142915 to N.M.).
Views and opinions expressed are, however, those of the author(s) only and do not
necessarily reflect those of the European Union or the European Research Council.
This research was funded in full or in part by the Austrian Science Fund (FWF, 10.55776/P37182
to N.M.). The technical staff of the NMR Centre of the Faculty of Chemistry (University
of Vienna) are acknowledged for crucial NMR measurements and expert advice with
spectral analysis. The authors thank the Core Facility Crystal Structure Analysis
(U. Vienna) for determination of the crystal structures. The authors are also grateful
to the University of Vienna for its continued support of our research programs.\r\n\r\nOpen
Access funding provided by Universität Wien."
article_number: e1233707
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Angela K.
full_name: Hofmeister, Angela K.
last_name: Hofmeister
- first_name: Giulia
full_name: Iannelli, Giulia
last_name: Iannelli
- first_name: Péter
full_name: Angyal, Péter
last_name: Angyal
- first_name: Augustin
full_name: Malandain, Augustin
last_name: Malandain
- first_name: Daniel
full_name: Kaiser, Daniel
last_name: Kaiser
- first_name: Boris
full_name: Maryasin, Boris
last_name: Maryasin
- first_name: Hanspeter
full_name: Kählig, Hanspeter
last_name: Kählig
- first_name: Matteo
full_name: Barel, Matteo
id: 8959927b-2236-11ed-bd6e-ea83d94ade0e
last_name: Barel
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
- first_name: Nuno
full_name: Maulide, Nuno
last_name: Maulide
citation:
ama: Hofmeister AK, Iannelli G, Angyal P, et al. Unified synthesis of unconventional
α-polyhalogenated amines through hydroaminoalkylation. Angewandte Chemie International
Edition. 2026. doi:10.1002/anie.1233707
apa: Hofmeister, A. K., Iannelli, G., Angyal, P., Malandain, A., Kaiser, D., Maryasin,
B., … Maulide, N. (2026). Unified synthesis of unconventional α-polyhalogenated
amines through hydroaminoalkylation. Angewandte Chemie International Edition.
Wiley. https://doi.org/10.1002/anie.1233707
chicago: Hofmeister, Angela K., Giulia Iannelli, Péter Angyal, Augustin Malandain,
Daniel Kaiser, Boris Maryasin, Hanspeter Kählig, Matteo Barel, Gaia Novarino,
and Nuno Maulide. “Unified Synthesis of Unconventional α-Polyhalogenated Amines
through Hydroaminoalkylation.” Angewandte Chemie International Edition.
Wiley, 2026. https://doi.org/10.1002/anie.1233707.
ieee: A. K. Hofmeister et al., “Unified synthesis of unconventional α-polyhalogenated
amines through hydroaminoalkylation,” Angewandte Chemie International Edition.
Wiley, 2026.
ista: Hofmeister AK, Iannelli G, Angyal P, Malandain A, Kaiser D, Maryasin B, Kählig
H, Barel M, Novarino G, Maulide N. 2026. Unified synthesis of unconventional α-polyhalogenated
amines through hydroaminoalkylation. Angewandte Chemie International Edition.,
e1233707.
mla: Hofmeister, Angela K., et al. “Unified Synthesis of Unconventional α-Polyhalogenated
Amines through Hydroaminoalkylation.” Angewandte Chemie International Edition,
e1233707, Wiley, 2026, doi:10.1002/anie.1233707.
short: A.K. Hofmeister, G. Iannelli, P. Angyal, A. Malandain, D. Kaiser, B. Maryasin,
H. Kählig, M. Barel, G. Novarino, N. Maulide, Angewandte Chemie International
Edition (2026).
das_tickbox: '1'
dataavailabilitystatement: The data that supports the findings of this study are available
in the supplementary material of this article.
date_created: 2026-07-19T22:01:48Z
date_published: 2026-07-10T00:00:00Z
date_updated: 2026-07-21T07:19:26Z
day: '10'
ddc:
- '570'
- '540'
department:
- _id: GaNo
- _id: GradSch
doi: 10.1002/anie.1233707
external_id:
pmid:
- '42429166'
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa_version: Published Version
pmid: 1
publication: Angewandte Chemie International Edition
publication_identifier:
eissn:
- 1521-3773
issn:
- 1433-7851
publication_status: epub_ahead
publisher: Wiley
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Unified synthesis of unconventional α-polyhalogenated amines through hydroaminoalkylation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...