---
_id: '11443'
abstract:
- lang: eng
  text: Sometimes, it is possible to represent a complicated polytope as a projection
    of a much simpler polytope. To quantify this phenomenon, the extension complexity
    of a polytope P is defined to be the minimum number of facets of a (possibly higher-dimensional)
    polytope from which P can be obtained as a (linear) projection. This notion is
    motivated by its relevance to combinatorial optimisation, and has been studied
    intensively for various specific polytopes associated with important optimisation
    problems. In this paper we study extension complexity as a parameter of general
    polytopes, more specifically considering various families of low-dimensional polytopes.
    First, we prove that for a fixed dimension d, the extension complexity of a random
    d-dimensional polytope (obtained as the convex hull of random points in a ball
    or on a sphere) is typically on the order of the square root of its number of
    vertices. Second, we prove that any cyclic n-vertex polygon (whose vertices lie
    on a circle) has extension complexity at most 24√n. This bound is tight up to
    the constant factor 24. Finally, we show that there exists an no(1)-dimensional
    polytope with at most n vertices and extension complexity n1−o(1). Our theorems
    are proved with a range of different techniques, which we hope will be of further
    interest.
acknowledgement: "The research of the first author was supported by SNSF Project 178493
  and NSF Award DMS-1953990. The research of the second author supported by NSF Award
  DMS-1953772.\r\nThe research of the third author was supported by NSF Award DMS-1764176,
  NSF CAREER Award DMS-2044606, a Sloan Research Fellowship, and the MIT Solomon Buchsbaum
  Fund. "
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Matthew Alan
  full_name: Kwan, Matthew Alan
  id: 5fca0887-a1db-11eb-95d1-ca9d5e0453b3
  last_name: Kwan
  orcid: 0000-0002-4003-7567
- first_name: Lisa
  full_name: Sauermann, Lisa
  last_name: Sauermann
- first_name: Yufei
  full_name: Zhao, Yufei
  last_name: Zhao
citation:
  ama: Kwan MA, Sauermann L, Zhao Y. Extension complexity of low-dimensional polytopes.
    <i>Transactions of the American Mathematical Society</i>. 2022;375(6):4209-4250.
    doi:<a href="https://doi.org/10.1090/tran/8614">10.1090/tran/8614</a>
  apa: Kwan, M. A., Sauermann, L., &#38; Zhao, Y. (2022). Extension complexity of
    low-dimensional polytopes. <i>Transactions of the American Mathematical Society</i>.
    American Mathematical Society. <a href="https://doi.org/10.1090/tran/8614">https://doi.org/10.1090/tran/8614</a>
  chicago: Kwan, Matthew Alan, Lisa Sauermann, and Yufei Zhao. “Extension Complexity
    of Low-Dimensional Polytopes.” <i>Transactions of the American Mathematical Society</i>.
    American Mathematical Society, 2022. <a href="https://doi.org/10.1090/tran/8614">https://doi.org/10.1090/tran/8614</a>.
  ieee: M. A. Kwan, L. Sauermann, and Y. Zhao, “Extension complexity of low-dimensional
    polytopes,” <i>Transactions of the American Mathematical Society</i>, vol. 375,
    no. 6. American Mathematical Society, pp. 4209–4250, 2022.
  ista: Kwan MA, Sauermann L, Zhao Y. 2022. Extension complexity of low-dimensional
    polytopes. Transactions of the American Mathematical Society. 375(6), 4209–4250.
  mla: Kwan, Matthew Alan, et al. “Extension Complexity of Low-Dimensional Polytopes.”
    <i>Transactions of the American Mathematical Society</i>, vol. 375, no. 6, American
    Mathematical Society, 2022, pp. 4209–50, doi:<a href="https://doi.org/10.1090/tran/8614">10.1090/tran/8614</a>.
  short: M.A. Kwan, L. Sauermann, Y. Zhao, Transactions of the American Mathematical
    Society 375 (2022) 4209–4250.
corr_author: '1'
date_created: 2022-06-12T22:01:45Z
date_published: 2022-06-01T00:00:00Z
date_updated: 2024-10-09T21:02:31Z
day: '01'
department:
- _id: MaKw
doi: 10.1090/tran/8614
external_id:
  arxiv:
  - '2006.08836'
  isi:
  - '000798461500001'
intvolume: '       375'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: ' https://doi.org/10.48550/arXiv.2006.08836'
month: '06'
oa: 1
oa_version: Preprint
page: 4209-4250
publication: Transactions of the American Mathematical Society
publication_identifier:
  eissn:
  - 1088-6850
  issn:
  - 0002-9947
publication_status: published
publisher: American Mathematical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Extension complexity of low-dimensional polytopes
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 375
year: '2022'
...
---
_id: '11444'
abstract:
- lang: eng
  text: "This article investigates library-related documents written by Gerard van
    Swieten (1700–72) during his tenure as Library Prefect in the Imperial Library
    of Vienna (1745–72). Van Swieten’s time as Library Prefect is considered through
    a textual analysis. Handwritten letters were deconstructed in terms of their appearance,
    layout, and tone in order to mine them for meaning. Furthermore, the contents
    were examined for library matters such as censorship, catalogues, and collection
    development. The Imperial Court Library held a prominent role as a repository
    for rare and valuable works, later becoming the National Library of Austria.\r\nGerard
    van Swieten’s work as a librarian tends to be overlooked, perhaps because he is
    better known as the private physician of Maria Theresia, as well as a medical
    reformer. Nevertheless, he was a hard-working chief librarian deeply involved
    in all aspects of librarianship. Van Swieten endorsed modern scientific works,
    which were otherwise banned officially by the censorship commission, for the use
    of scholars in the library, expanded the collection by acquiring books through
    his network of scholars and publishers, and reissued library catalogues. He also
    provided for the comfort of users in the library reading room, at a time when
    such considerations were unusual. In conclusion, a proposal is made that van Swieten
    viewed his role as librarian with some importance and pride."
article_processing_charge: No
article_type: original
author:
- first_name: Clara A
  full_name: Chlebak, Clara A
  id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
  last_name: Chlebak
  orcid: 0000-0002-3385-3865
- first_name: Peter H.
  full_name: Reid, Peter H.
  last_name: Reid
citation:
  ama: 'Chlebak CA, Reid PH. From the prefect’s desk: Gerard van Swieten’s library
    correspondence. <i>Library and Information History</i>. 2022;38(1):23-41. doi:<a
    href="https://doi.org/10.3366/lih.2022.0097">10.3366/lih.2022.0097</a>'
  apa: 'Chlebak, C. A., &#38; Reid, P. H. (2022). From the prefect’s desk: Gerard
    van Swieten’s library correspondence. <i>Library and Information History</i>.
    Edinburgh University Press. <a href="https://doi.org/10.3366/lih.2022.0097">https://doi.org/10.3366/lih.2022.0097</a>'
  chicago: 'Chlebak, Clara A, and Peter H. Reid. “From the Prefect’s Desk: Gerard
    van Swieten’s Library Correspondence.” <i>Library and Information History</i>.
    Edinburgh University Press, 2022. <a href="https://doi.org/10.3366/lih.2022.0097">https://doi.org/10.3366/lih.2022.0097</a>.'
  ieee: 'C. A. Chlebak and P. H. Reid, “From the prefect’s desk: Gerard van Swieten’s
    library correspondence,” <i>Library and Information History</i>, vol. 38, no.
    1. Edinburgh University Press, pp. 23–41, 2022.'
  ista: 'Chlebak CA, Reid PH. 2022. From the prefect’s desk: Gerard van Swieten’s
    library correspondence. Library and Information History. 38(1), 23–41.'
  mla: 'Chlebak, Clara A., and Peter H. Reid. “From the Prefect’s Desk: Gerard van
    Swieten’s Library Correspondence.” <i>Library and Information History</i>, vol.
    38, no. 1, Edinburgh University Press, 2022, pp. 23–41, doi:<a href="https://doi.org/10.3366/lih.2022.0097">10.3366/lih.2022.0097</a>.'
  short: C.A. Chlebak, P.H. Reid, Library and Information History 38 (2022) 23–41.
corr_author: '1'
date_created: 2022-06-12T22:01:45Z
date_published: 2022-04-01T00:00:00Z
date_updated: 2024-10-09T21:02:31Z
day: '01'
department:
- _id: E-Lib
doi: 10.3366/lih.2022.0097
intvolume: '        38'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://rgu-repository.worktribe.com/output/1635939
month: '04'
oa: 1
oa_version: Submitted Version
page: 23-41
publication: Library and Information History
publication_identifier:
  eissn:
  - 1758-3497
  issn:
  - 1758-3489
publication_status: published
publisher: Edinburgh University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'From the prefect’s desk: Gerard van Swieten’s library correspondence'
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 38
year: '2022'
...
---
_id: '11447'
abstract:
- lang: eng
  text: Empirical essays of fitness landscapes suggest that they may be rugged, that
    is having multiple fitness peaks. Such fitness landscapes, those that have multiple
    peaks, necessarily have special local structures, called reciprocal sign epistasis
    (Poelwijk et al. in J Theor Biol 272:141–144, 2011). Here, we investigate the
    quantitative relationship between the number of fitness peaks and the number of
    reciprocal sign epistatic interactions. Previously, it has been shown (Poelwijk
    et al. in J Theor Biol 272:141–144, 2011) that pairwise reciprocal sign epistasis
    is a necessary but not sufficient condition for the existence of multiple peaks.
    Applying discrete Morse theory, which to our knowledge has never been used in
    this context, we extend this result by giving the minimal number of reciprocal
    sign epistatic interactions required to create a given number of peaks.
acknowledgement: We are grateful to Herbert Edelsbrunner and Jeferson Zapata for helpful
  discussions. Open access funding provided by Austrian Science Fund (FWF). Partially
  supported by the ERC Consolidator (771209–CharFL) and the FWF Austrian Science Fund
  (I5127-B) grants to FAK.
article_number: '74'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Raimundo J
  full_name: Saona Urmeneta, Raimundo J
  id: BD1DF4C4-D767-11E9-B658-BC13E6697425
  last_name: Saona Urmeneta
  orcid: 0000-0001-5103-038X
- first_name: Fyodor
  full_name: Kondrashov, Fyodor
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
- first_name: Kseniia
  full_name: Khudiakova, Kseniia
  id: 4E6DC800-AE37-11E9-AC72-31CAE5697425
  last_name: Khudiakova
  orcid: 0000-0002-6246-1465
citation:
  ama: Saona Urmeneta RJ, Kondrashov F, Khudiakova K. Relation between the number
    of peaks and the number of reciprocal sign epistatic interactions. <i>Bulletin
    of Mathematical Biology</i>. 2022;84(8). doi:<a href="https://doi.org/10.1007/s11538-022-01029-z">10.1007/s11538-022-01029-z</a>
  apa: Saona Urmeneta, R. J., Kondrashov, F., &#38; Khudiakova, K. (2022). Relation
    between the number of peaks and the number of reciprocal sign epistatic interactions.
    <i>Bulletin of Mathematical Biology</i>. Springer Nature. <a href="https://doi.org/10.1007/s11538-022-01029-z">https://doi.org/10.1007/s11538-022-01029-z</a>
  chicago: Saona Urmeneta, Raimundo J, Fyodor Kondrashov, and Kseniia Khudiakova.
    “Relation between the Number of Peaks and the Number of Reciprocal Sign Epistatic
    Interactions.” <i>Bulletin of Mathematical Biology</i>. Springer Nature, 2022.
    <a href="https://doi.org/10.1007/s11538-022-01029-z">https://doi.org/10.1007/s11538-022-01029-z</a>.
  ieee: R. J. Saona Urmeneta, F. Kondrashov, and K. Khudiakova, “Relation between
    the number of peaks and the number of reciprocal sign epistatic interactions,”
    <i>Bulletin of Mathematical Biology</i>, vol. 84, no. 8. Springer Nature, 2022.
  ista: Saona Urmeneta RJ, Kondrashov F, Khudiakova K. 2022. Relation between the
    number of peaks and the number of reciprocal sign epistatic interactions. Bulletin
    of Mathematical Biology. 84(8), 74.
  mla: Saona Urmeneta, Raimundo J., et al. “Relation between the Number of Peaks and
    the Number of Reciprocal Sign Epistatic Interactions.” <i>Bulletin of Mathematical
    Biology</i>, vol. 84, no. 8, 74, Springer Nature, 2022, doi:<a href="https://doi.org/10.1007/s11538-022-01029-z">10.1007/s11538-022-01029-z</a>.
  short: R.J. Saona Urmeneta, F. Kondrashov, K. Khudiakova, Bulletin of Mathematical
    Biology 84 (2022).
corr_author: '1'
date_created: 2022-06-17T16:16:15Z
date_published: 2022-06-17T00:00:00Z
date_updated: 2026-06-12T12:43:34Z
day: '17'
ddc:
- '510'
- '570'
department:
- _id: GradSch
- _id: NiBa
- _id: JaMa
doi: 10.1007/s11538-022-01029-z
ec_funded: 1
external_id:
  isi:
  - '000812509800001'
  pmid:
  - '35713756'
file:
- access_level: open_access
  checksum: 05a1fe7d10914a00c2bca9b447993a65
  content_type: application/pdf
  creator: dernst
  date_created: 2022-06-20T07:51:32Z
  date_updated: 2022-06-20T07:51:32Z
  file_id: '11455'
  file_name: 2022_BulletinMathBiology_Saona.pdf
  file_size: 463025
  relation: main_file
  success: 1
file_date_updated: 2022-06-20T07:51:32Z
has_accepted_license: '1'
intvolume: '        84'
isi: 1
issue: '8'
keyword:
- Computational Theory and Mathematics
- General Agricultural and Biological Sciences
- Pharmacology
- General Environmental Science
- General Biochemistry
- Genetics and Molecular Biology
- General Mathematics
- Immunology
- General Neuroscience
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 26580278-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '771209'
  name: Characterizing the fitness landscape on population and global scales
- _id: 34e076d6-11ca-11ed-8bc3-aec76c41a181
  grant_number: I05127
  name: Evolutionary analysis of gene regulation
publication: Bulletin of Mathematical Biology
publication_identifier:
  eissn:
  - 1522-9602
  issn:
  - 0092-8240
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - relation: erratum
    url: https://doi.org/10.1007/s11538-022-01118-z
  record:
  - id: '21918'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Relation between the number of peaks and the number of reciprocal sign epistatic
  interactions
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 84
year: '2022'
...
---
_id: '11448'
abstract:
- lang: eng
  text: Studies of protein fitness landscapes reveal biophysical constraints guiding
    protein evolution and empower prediction of functional proteins. However, generalisation
    of these findings is limited due to scarceness of systematic data on fitness landscapes
    of proteins with a defined evolutionary relationship. We characterized the fitness
    peaks of four orthologous fluorescent proteins with a broad range of sequence
    divergence. While two of the four studied fitness peaks were sharp, the other
    two were considerably flatter, being almost entirely free of epistatic interactions.
    Mutationally robust proteins, characterized by a flat fitness peak, were not optimal
    templates for machine-learning-driven protein design – instead, predictions were
    more accurate for fragile proteins with epistatic landscapes. Our work paves insights
    for practical application of fitness landscape heterogeneity in protein engineering.
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
acknowledgement: "We thank Ondřej Draganov, Rodrigo Redondo, Bor Kavčič, Mia Juračić
  and Andrea Pauli for discussion and technical advice. We thank Anita Testa Salmazo
  for advice on resin protein purification, Dmitry Bolotin and the Milaboratory (milaboratory.com)
  for access to computing and storage infrastructure, and Josef Houser and Eva Fujdiarova
  for technical assistance and data interpretation. Core facility Biomolecular Interactions
  and Crystallization of CEITEC Masaryk University is gratefully acknowledged for
  the obtaining of the scientific data presented in this paper. This research was
  supported by the Scientific Service Units (SSU) of IST-Austria\r\nthrough resources
  provided by the Bioimaging Facility (BIF), and the Life Science Facility (LSF).
  MiSeq and HiSeq NGS sequencing was performed by the Next Generation Sequencing Facility
  at Vienna BioCenter Core Facilities (VBCF), member of the Vienna BioCenter (VBC),
  Austria. FACS was performed at the BioOptics Facility of the Institute of Molecular
  Pathology (IMP), Austria. We also thank the Biomolecular Crystallography Facility
  in the Vanderbilt University Center for Structural Biology. We are grateful to Joel
  M Harp for help with X-ray data collection. This work was supported by the ERC Consolidator
  grant to FAK (771209—CharFL). KSS acknowledges support by President’s Grant МК–5405.2021.1.4,
  the Imperial College Research Fellowship and the MRC London Institute of Medical
  Sciences (UKRI MC-A658-5QEA0).\r\nAF is supported by the Marie Skłodowska-Curie
  Fellowship (H2020-MSCA-IF-2019, Grant Agreement No. 898203, Project acronym \"FLINDIP\").
  Experiments were partially carried out using equipment provided by the Institute
  of Bioorganic Chemistry of the Russian Academy of Sciences Сore Facility (CKP IBCH).
  This work was supported by a Russian Science Foundation grant 19-74-10102.This project
  has received funding from the European Union’s Horizon 2020 research and innovation
  programme under the Marie Skłodowska-Curie Grant Agreement No. 665,385."
article_number: '75842'
article_processing_charge: No
article_type: original
author:
- first_name: Louisa
  full_name: Gonzalez Somermeyer, Louisa
  id: 4720D23C-F248-11E8-B48F-1D18A9856A87
  last_name: Gonzalez Somermeyer
  orcid: 0000-0001-9139-5383
- first_name: Aubin
  full_name: Fleiss, Aubin
  last_name: Fleiss
- first_name: Alexander S
  full_name: Mishin, Alexander S
  last_name: Mishin
- first_name: Nina G
  full_name: Bozhanova, Nina G
  last_name: Bozhanova
- first_name: Anna A
  full_name: Igolkina, Anna A
  last_name: Igolkina
- first_name: Jens
  full_name: Meiler, Jens
  last_name: Meiler
- first_name: Maria-Elisenda
  full_name: Alaball Pujol, Maria-Elisenda
  last_name: Alaball Pujol
- first_name: Ekaterina V
  full_name: Putintseva, Ekaterina V
  last_name: Putintseva
- first_name: Karen S
  full_name: Sarkisyan, Karen S
  last_name: Sarkisyan
- first_name: Fyodor
  full_name: Kondrashov, Fyodor
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
citation:
  ama: Gonzalez Somermeyer L, Fleiss A, Mishin AS, et al. Heterogeneity of the GFP
    fitness landscape and data-driven protein design. <i>eLife</i>. 2022;11. doi:<a
    href="https://doi.org/10.7554/elife.75842">10.7554/elife.75842</a>
  apa: Gonzalez Somermeyer, L., Fleiss, A., Mishin, A. S., Bozhanova, N. G., Igolkina,
    A. A., Meiler, J., … Kondrashov, F. (2022). Heterogeneity of the GFP fitness landscape
    and data-driven protein design. <i>ELife</i>. eLife Sciences Publications. <a
    href="https://doi.org/10.7554/elife.75842">https://doi.org/10.7554/elife.75842</a>
  chicago: Gonzalez Somermeyer, Louisa, Aubin Fleiss, Alexander S Mishin, Nina G Bozhanova,
    Anna A Igolkina, Jens Meiler, Maria-Elisenda Alaball Pujol, Ekaterina V Putintseva,
    Karen S Sarkisyan, and Fyodor Kondrashov. “Heterogeneity of the GFP Fitness Landscape
    and Data-Driven Protein Design.” <i>ELife</i>. eLife Sciences Publications, 2022.
    <a href="https://doi.org/10.7554/elife.75842">https://doi.org/10.7554/elife.75842</a>.
  ieee: L. Gonzalez Somermeyer <i>et al.</i>, “Heterogeneity of the GFP fitness landscape
    and data-driven protein design,” <i>eLife</i>, vol. 11. eLife Sciences Publications,
    2022.
  ista: Gonzalez Somermeyer L, Fleiss A, Mishin AS, Bozhanova NG, Igolkina AA, Meiler
    J, Alaball Pujol M-E, Putintseva EV, Sarkisyan KS, Kondrashov F. 2022. Heterogeneity
    of the GFP fitness landscape and data-driven protein design. eLife. 11, 75842.
  mla: Gonzalez Somermeyer, Louisa, et al. “Heterogeneity of the GFP Fitness Landscape
    and Data-Driven Protein Design.” <i>ELife</i>, vol. 11, 75842, eLife Sciences
    Publications, 2022, doi:<a href="https://doi.org/10.7554/elife.75842">10.7554/elife.75842</a>.
  short: L. Gonzalez Somermeyer, A. Fleiss, A.S. Mishin, N.G. Bozhanova, A.A. Igolkina,
    J. Meiler, M.-E. Alaball Pujol, E.V. Putintseva, K.S. Sarkisyan, F. Kondrashov,
    ELife 11 (2022).
corr_author: '1'
date_created: 2022-06-18T09:06:59Z
date_published: 2022-05-05T00:00:00Z
date_updated: 2026-04-07T13:25:01Z
day: '05'
ddc:
- '570'
department:
- _id: GradSch
- _id: FyKo
doi: 10.7554/elife.75842
ec_funded: 1
external_id:
  isi:
  - '000799197200001'
  pmid:
  - '35510622'
file:
- access_level: open_access
  checksum: 7573c28f44028ab0cc81faef30039e44
  content_type: application/pdf
  creator: dernst
  date_created: 2022-06-20T07:44:19Z
  date_updated: 2022-06-20T07:44:19Z
  file_id: '11454'
  file_name: 2022_eLife_Somermeyer.pdf
  file_size: 5297213
  relation: main_file
  success: 1
file_date_updated: 2022-06-20T07:44:19Z
has_accepted_license: '1'
intvolume: '        11'
isi: 1
keyword:
- General Immunology and Microbiology
- General Biochemistry
- Genetics and Molecular Biology
- General Medicine
- General Neuroscience
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 26580278-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '771209'
  name: Characterizing the fitness landscape on population and global scales
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication: eLife
publication_identifier:
  issn:
  - 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
related_material:
  link:
  - relation: software
    url: https://github.com/aequorea238/Orthologous_GFP_Fitness_Peaks
  record:
  - id: '17850'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Heterogeneity of the GFP fitness landscape and data-driven protein design
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2022'
...
---
_id: '11449'
abstract:
- lang: eng
  text: Mutations are acquired frequently, such that each cell's genome inscribes
    its history of cell divisions. Common genomic alterations involve loss of heterozygosity
    (LOH). LOH accumulates throughout the genome, offering large encoding capacity
    for inferring cell lineage. Using only single-cell RNA sequencing (scRNA-seq)
    of mouse brain cells, we found that LOH events spanning multiple genes are revealed
    as tracts of monoallelically expressed, constitutionally heterozygous single-nucleotide
    variants (SNVs). We simultaneously inferred cell lineage and marked developmental
    time points based on X chromosome inactivation and the total number of LOH events
    while identifying cell types from gene expression patterns. Our results are consistent
    with progenitor cells giving rise to multiple cortical cell types through stereotyped
    expansion and distinct waves of neurogenesis. This type of retrospective analysis
    could be incorporated into scRNA-seq pipelines and, compared with experimental
    approaches for determining lineage in model organisms, is applicable where genetic
    engineering is prohibited, such as humans.
acknowledgement: D.J.A. thanks Wayne K. Potts, Alan R. Rogers, Kristen Hawkes, Ryk
  Ward, and Jon Seger for inspiring a young undergraduate to apply evolutionary theory
  to intraorganism development. Supported by the Paul G. Allen Frontiers Group (University
  of Washington); NIH R00HG010152 (Dartmouth); and NÖ Forschung und Bildung n[f+b]
  life science call grant (C13-002) and the European Research Council (ERC) under
  the European Union’s Horizon 2020 research and innovation program 725780 LinPro
  to S.H.
article_processing_charge: No
article_type: original
author:
- first_name: Donovan J.
  full_name: Anderson, Donovan J.
  last_name: Anderson
- first_name: Florian
  full_name: Pauler, Florian
  id: 48EA0138-F248-11E8-B48F-1D18A9856A87
  last_name: Pauler
  orcid: 0000-0002-7462-0048
- first_name: Aaron
  full_name: Mckenna, Aaron
  last_name: Mckenna
- first_name: Jay
  full_name: Shendure, Jay
  last_name: Shendure
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: Marshall S.
  full_name: Horwitz, Marshall S.
  last_name: Horwitz
citation:
  ama: Anderson DJ, Pauler F, Mckenna A, Shendure J, Hippenmeyer S, Horwitz MS. Simultaneous
    brain cell type and lineage determined by scRNA-seq reveals stereotyped cortical
    development. <i>Cell Systems</i>. 2022;13(6):438-453.e5. doi:<a href="https://doi.org/10.1016/j.cels.2022.03.006">10.1016/j.cels.2022.03.006</a>
  apa: Anderson, D. J., Pauler, F., Mckenna, A., Shendure, J., Hippenmeyer, S., &#38;
    Horwitz, M. S. (2022). Simultaneous brain cell type and lineage determined by
    scRNA-seq reveals stereotyped cortical development. <i>Cell Systems</i>. Elsevier.
    <a href="https://doi.org/10.1016/j.cels.2022.03.006">https://doi.org/10.1016/j.cels.2022.03.006</a>
  chicago: Anderson, Donovan J., Florian Pauler, Aaron Mckenna, Jay Shendure, Simon
    Hippenmeyer, and Marshall S. Horwitz. “Simultaneous Brain Cell Type and Lineage
    Determined by ScRNA-Seq Reveals Stereotyped Cortical Development.” <i>Cell Systems</i>.
    Elsevier, 2022. <a href="https://doi.org/10.1016/j.cels.2022.03.006">https://doi.org/10.1016/j.cels.2022.03.006</a>.
  ieee: D. J. Anderson, F. Pauler, A. Mckenna, J. Shendure, S. Hippenmeyer, and M.
    S. Horwitz, “Simultaneous brain cell type and lineage determined by scRNA-seq
    reveals stereotyped cortical development,” <i>Cell Systems</i>, vol. 13, no. 6.
    Elsevier, p. 438–453.e5, 2022.
  ista: Anderson DJ, Pauler F, Mckenna A, Shendure J, Hippenmeyer S, Horwitz MS. 2022.
    Simultaneous brain cell type and lineage determined by scRNA-seq reveals stereotyped
    cortical development. Cell Systems. 13(6), 438–453.e5.
  mla: Anderson, Donovan J., et al. “Simultaneous Brain Cell Type and Lineage Determined
    by ScRNA-Seq Reveals Stereotyped Cortical Development.” <i>Cell Systems</i>, vol.
    13, no. 6, Elsevier, 2022, p. 438–453.e5, doi:<a href="https://doi.org/10.1016/j.cels.2022.03.006">10.1016/j.cels.2022.03.006</a>.
  short: D.J. Anderson, F. Pauler, A. Mckenna, J. Shendure, S. Hippenmeyer, M.S. Horwitz,
    Cell Systems 13 (2022) 438–453.e5.
date_created: 2022-06-19T22:01:57Z
date_published: 2022-06-15T00:00:00Z
date_updated: 2026-06-18T17:15:22Z
day: '15'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1016/j.cels.2022.03.006
ec_funded: 1
external_id:
  isi:
  - '000814124400002'
  pmid:
  - '35452605'
intvolume: '        13'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.cels.2022.03.006
month: '06'
oa: 1
oa_version: Published Version
page: 438-453.e5
pmid: 1
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '725780'
  name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
- _id: 25D92700-B435-11E9-9278-68D0E5697425
  grant_number: LS13-002
  name: Mapping Cell-Type Specificity of the Genomic Imprintome in the Brain
publication: Cell Systems
publication_identifier:
  eissn:
  - 2405-4720
  issn:
  - 2405-4712
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Simultaneous brain cell type and lineage determined by scRNA-seq reveals stereotyped
  cortical development
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2022'
...
---
_id: '11456'
abstract:
- lang: eng
  text: The proteomes of specialized structures, and the interactomes of proteins
    of interest, provide entry points to elucidate the functions of molecular machines.
    Here, we review a proximity-labeling strategy that uses the improved E. coli biotin
    ligase TurboID to characterize C. elegans protein complexes. Although the focus
    is on C. elegans neurons, the method is applicable regardless of cell type. We
    describe detailed extraction procedures that solubilize the bulk of C. elegans
    proteins and highlight the importance of tagging endogenous genes, to ensure physiological
    expression levels. We review issues associated with non-specific background noise
    and the importance of appropriate controls. As proof of principle, we review our
    analysis of the interactome of a presynaptic active zone protein, ELKS-1. Our
    aim is to provide a detailed protocol for TurboID-based proximity labeling in
    C. elegans and to highlight its potential and its limitations to characterize
    protein complexes and subcellular compartments in this animal.
acknowledgement: We thank de Bono lab members for the helpful comments on the manuscript.
  The biotin-auxotrophic E. coli strain MG1655bioB:kan was a generous gift from J.
  Cronan (University of Illinois) and was kindly sent to us by Jessica Feldman and
  Ariana Sanchez (Stanford University). dg398 pEntryslot2_mNeongreen::3XFLAG::stop
  and dg397 pEntryslot3_mNeongreen::3XFLAG::stop::unc-54 3’UTR entry vector were kindly
  sent by Dr. Dominique Glauser (University of Fribourg). This work was supported
  by an Advanced ERC Grant (269058 ACMO) and a Wellcome Investigator Award (209504/Z/17/Z)
  to MdB and an ISTplus Fellowship to MA (Marie Sklodowska-Curie agreement No 754411).
alternative_title:
- Neuromethods
article_processing_charge: No
author:
- first_name: Murat
  full_name: Artan, Murat
  id: C407B586-6052-11E9-B3AE-7006E6697425
  last_name: Artan
  orcid: 0000-0001-8945-6992
- first_name: Mario
  full_name: de Bono, Mario
  id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
  last_name: de Bono
  orcid: 0000-0001-8347-0443
citation:
  ama: 'Artan M, de Bono M. Proteomic Analysis of C. Elegans Neurons Using TurboID-Based
    Proximity Labeling. In: Yamamoto D, ed. <i>Behavioral Neurogenetics</i>. Vol 181.
    NM. New York: Springer Nature; 2022:277-294. doi:<a href="https://doi.org/10.1007/978-1-0716-2321-3_15">10.1007/978-1-0716-2321-3_15</a>'
  apa: 'Artan, M., &#38; de Bono, M. (2022). Proteomic Analysis of C. Elegans Neurons
    Using TurboID-Based Proximity Labeling. In D. Yamamoto (Ed.), <i>Behavioral Neurogenetics</i>
    (Vol. 181, pp. 277–294). New York: Springer Nature. <a href="https://doi.org/10.1007/978-1-0716-2321-3_15">https://doi.org/10.1007/978-1-0716-2321-3_15</a>'
  chicago: 'Artan, Murat, and Mario de Bono. “Proteomic Analysis of C. Elegans Neurons
    Using TurboID-Based Proximity Labeling.” In <i>Behavioral Neurogenetics</i>, edited
    by Daisuke Yamamoto, 181:277–94. NM. New York: Springer Nature, 2022. <a href="https://doi.org/10.1007/978-1-0716-2321-3_15">https://doi.org/10.1007/978-1-0716-2321-3_15</a>.'
  ieee: 'M. Artan and M. de Bono, “Proteomic Analysis of C. Elegans Neurons Using
    TurboID-Based Proximity Labeling,” in <i>Behavioral Neurogenetics</i>, vol. 181,
    D. Yamamoto, Ed. New York: Springer Nature, 2022, pp. 277–294.'
  ista: 'Artan M, de Bono M. 2022.Proteomic Analysis of C. Elegans Neurons Using TurboID-Based
    Proximity Labeling. In: Behavioral Neurogenetics. Neuromethods, vol. 181, 277–294.'
  mla: Artan, Murat, and Mario de Bono. “Proteomic Analysis of C. Elegans Neurons
    Using TurboID-Based Proximity Labeling.” <i>Behavioral Neurogenetics</i>, edited
    by Daisuke Yamamoto, vol. 181, Springer Nature, 2022, pp. 277–94, doi:<a href="https://doi.org/10.1007/978-1-0716-2321-3_15">10.1007/978-1-0716-2321-3_15</a>.
  short: M. Artan, M. de Bono, in:, D. Yamamoto (Ed.), Behavioral Neurogenetics, Springer
    Nature, New York, 2022, pp. 277–294.
corr_author: '1'
date_created: 2022-06-20T08:10:34Z
date_published: 2022-06-04T00:00:00Z
date_updated: 2025-04-14T07:43:58Z
day: '04'
department:
- _id: MaDe
doi: 10.1007/978-1-0716-2321-3_15
ec_funded: 1
editor:
- first_name: Daisuke
  full_name: Yamamoto, Daisuke
  last_name: Yamamoto
intvolume: '       181'
language:
- iso: eng
month: '06'
oa_version: None
page: 277-294
place: New York
project:
- _id: 23870BE8-32DE-11EA-91FC-C7463DDC885E
  grant_number: 209504/A/17/Z
  name: Molecular mechanisms of neural circuit function
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: Behavioral Neurogenetics
publication_identifier:
  eisbn:
  - '9781071623213'
  eissn:
  - 1940-6045
  isbn:
  - '9781071623206'
  issn:
  - 0893-2336
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
series_title: NM
status: public
title: Proteomic Analysis of C. Elegans Neurons Using TurboID-Based Proximity Labeling
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 181
year: '2022'
...
---
_id: '11459'
abstract:
- lang: eng
  text: 'We present a novel approach to differential cost analysis that, given a program
    revision, attempts to statically bound the difference in resource usage, or cost,
    between the two program versions. Differential cost analysis is particularly interesting
    because of the many compelling applications for it, such as detecting resource-use
    regressions at code-review time or proving the absence of certain side-channel
    vulnerabilities. One prior approach to differential cost analysis is to apply
    relational reasoning that conceptually constructs a product program on which one
    can over-approximate the difference in costs between the two program versions.
    However, a significant challenge in any relational approach is effectively aligning
    the program versions to get precise results. In this paper, our key insight is
    that we can avoid the need for and the limitations of program alignment if, instead,
    we bound the difference of two cost-bound summaries rather than directly bounding
    the concrete cost difference. In particular, our method computes a threshold value
    for the maximal difference in cost between two program versions simultaneously
    using two kinds of cost-bound summaries---a potential function that evaluates
    to an upper bound for the cost incurred in the first program and an anti-potential
    function that evaluates to a lower bound for the cost incurred in the second.
    Our method has a number of desirable properties: it can be fully automated, it
    allows optimizing the threshold value on relative cost, it is suitable for programs
    that are not syntactically similar, and it supports non-determinism. We have evaluated
    an implementation of our approach on a number of program pairs collected from
    the literature, and we find that our method computes tight threshold values on
    relative cost in most examples.'
acknowledgement: "We thank Shaun Willows, Thomas Lugnet, and the Living Room Application
  Vending team for suggesting threshold\r\nbounds as a developer-friendly way to interact
  with a differential cost analyzer, and we thank Jim Christy, Daniel\r\nSchoepe,
  and the Prime Video Automated Reasoning team for their support and helpful suggestions
  throughout the\r\nproject. We also thank Michael Emmi for feedback on an earlier
  version of this paper. And finally, we thank the anonymous reviewers for their useful
  feedback and Aws Albarghouthi for shepherding the final version of the paper. Ðorđe
  Žikelić was also partially supported by ERC CoG 863818 (FoRM-SMArt)."
article_processing_charge: No
arxiv: 1
author:
- first_name: Dorde
  full_name: Zikelic, Dorde
  id: 294AA7A6-F248-11E8-B48F-1D18A9856A87
  last_name: Zikelic
  orcid: 0000-0002-4681-1699
- first_name: Bor-Yuh Evan
  full_name: Chang, Bor-Yuh Evan
  last_name: Chang
- first_name: Pauline
  full_name: Bolignano, Pauline
  last_name: Bolignano
- first_name: Franco
  full_name: Raimondi, Franco
  last_name: Raimondi
citation:
  ama: 'Zikelic D, Chang B-YE, Bolignano P, Raimondi F. Differential cost analysis
    with simultaneous potentials and anti-potentials. In: <i>Proceedings of the 43rd
    ACM SIGPLAN International Conference on Programming Language Design and Implementation</i>.
    Association for Computing Machinery; 2022:442-457. doi:<a href="https://doi.org/10.1145/3519939.3523435">10.1145/3519939.3523435</a>'
  apa: 'Zikelic, D., Chang, B.-Y. E., Bolignano, P., &#38; Raimondi, F. (2022). Differential
    cost analysis with simultaneous potentials and anti-potentials. In <i>Proceedings
    of the 43rd ACM SIGPLAN International Conference on Programming Language Design
    and Implementation</i> (pp. 442–457). San Diego, CA, United States: Association
    for Computing Machinery. <a href="https://doi.org/10.1145/3519939.3523435">https://doi.org/10.1145/3519939.3523435</a>'
  chicago: Zikelic, Dorde, Bor-Yuh Evan Chang, Pauline Bolignano, and Franco Raimondi.
    “Differential Cost Analysis with Simultaneous Potentials and Anti-Potentials.”
    In <i>Proceedings of the 43rd ACM SIGPLAN International Conference on Programming
    Language Design and Implementation</i>, 442–57. Association for Computing Machinery,
    2022. <a href="https://doi.org/10.1145/3519939.3523435">https://doi.org/10.1145/3519939.3523435</a>.
  ieee: D. Zikelic, B.-Y. E. Chang, P. Bolignano, and F. Raimondi, “Differential cost
    analysis with simultaneous potentials and anti-potentials,” in <i>Proceedings
    of the 43rd ACM SIGPLAN International Conference on Programming Language Design
    and Implementation</i>, San Diego, CA, United States, 2022, pp. 442–457.
  ista: 'Zikelic D, Chang B-YE, Bolignano P, Raimondi F. 2022. Differential cost analysis
    with simultaneous potentials and anti-potentials. Proceedings of the 43rd ACM
    SIGPLAN International Conference on Programming Language Design and Implementation.
    PLDI: Programming Language Design and Implementation, 442–457.'
  mla: Zikelic, Dorde, et al. “Differential Cost Analysis with Simultaneous Potentials
    and Anti-Potentials.” <i>Proceedings of the 43rd ACM SIGPLAN International Conference
    on Programming Language Design and Implementation</i>, Association for Computing
    Machinery, 2022, pp. 442–57, doi:<a href="https://doi.org/10.1145/3519939.3523435">10.1145/3519939.3523435</a>.
  short: D. Zikelic, B.-Y.E. Chang, P. Bolignano, F. Raimondi, in:, Proceedings of
    the 43rd ACM SIGPLAN International Conference on Programming Language Design and
    Implementation, Association for Computing Machinery, 2022, pp. 442–457.
conference:
  end_date: 2022-06-17
  location: San Diego, CA, United States
  name: 'PLDI: Programming Language Design and Implementation'
  start_date: 2022-06-13
corr_author: '1'
date_created: 2022-06-21T09:26:15Z
date_published: 2022-06-09T00:00:00Z
date_updated: 2025-04-14T07:52:47Z
day: '09'
ddc:
- '000'
department:
- _id: GradSch
- _id: KrCh
doi: 10.1145/3519939.3523435
ec_funded: 1
external_id:
  arxiv:
  - '2204.00870'
  isi:
  - '000850435600030'
file:
- access_level: open_access
  checksum: 7eb915a2ca5b5ce4729321f33b2e16e1
  content_type: application/pdf
  creator: dernst
  date_created: 2022-06-27T07:38:21Z
  date_updated: 2022-06-27T07:38:21Z
  file_id: '11466'
  file_name: 2022_PLDI_Zikelic.pdf
  file_size: 318697
  relation: main_file
  success: 1
file_date_updated: 2022-06-27T07:38:21Z
has_accepted_license: '1'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '06'
oa: 1
oa_version: Published Version
page: 442-457
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
  call_identifier: H2020
  grant_number: '863818'
  name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
publication: Proceedings of the 43rd ACM SIGPLAN International Conference on Programming
  Language Design and Implementation
publication_identifier:
  isbn:
  - '9781450392655'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential cost analysis with simultaneous potentials and anti-potentials
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
year: '2022'
...
---
_id: '11460'
abstract:
- lang: eng
  text: "Background: Proper cerebral cortical development depends on the tightly orchestrated
    migration of newly born neurons from the inner ventricular and subventricular
    zones to the outer cortical plate. Any disturbance in this process during prenatal
    stages may lead to neuronal migration disorders (NMDs), which can vary in extent
    from focal to global. Furthermore, NMDs show a substantial comorbidity with other
    neurodevelopmental disorders, notably autism spectrum disorders (ASDs). Our previous
    work demonstrated focal neuronal migration defects in mice carrying loss-of-function
    alleles of the recognized autism risk gene WDFY3. However, the cellular origins
    of these defects in Wdfy3 mutant mice remain elusive and uncovering it will provide
    critical insight into WDFY3-dependent disease pathology.\r\nMethods: Here, in
    an effort to untangle the origins of NMDs in Wdfy3lacZ mice, we employed mosaic
    analysis with double markers (MADM). MADM technology enabled us to genetically
    distinctly track and phenotypically analyze mutant and wild-type cells concomitantly
    in vivo using immunofluorescent techniques.\r\nResults: We revealed a cell autonomous
    requirement of WDFY3 for accurate laminar positioning of cortical projection neurons
    and elimination of mispositioned cells during early postnatal life. In addition,
    we identified significant deviations in dendritic arborization, as well as synaptic
    density and morphology between wild type, heterozygous, and homozygous Wdfy3 mutant
    neurons in Wdfy3-MADM reporter mice at postnatal stages.\r\nLimitations: While
    Wdfy3 mutant mice have provided valuable insight into prenatal aspects of ASD
    pathology that remain inaccessible to investigation in humans, like most animal
    models, they do not a perfectly replicate all aspects of human ASD biology. The
    lack of human data makes it indeterminate whether morphological deviations described
    here apply to ASD patients or some of the other neurodevelopmental conditions
    associated with WDFY3 mutation.\r\nConclusions: Our genetic approach revealed
    several cell autonomous requirements of WDFY3 in neuronal development that could
    underlie the pathogenic mechanisms of WDFY3-related neurodevelopmental conditions.
    The results are also consistent with findings in other ASD animal models and patients
    and suggest an important role for WDFY3 in regulating neuronal function and interconnectivity
    in postnatal life."
acknowledgement: "This study was funded by NIMH R21MH115347 to KSZ. KSZ is further
  supported by Shriners Hospitals for Children.\r\nWe would like to thank Angelo Harlan
  de Crescenzo for early contributions to this project."
article_number: '27'
article_processing_charge: No
article_type: original
author:
- first_name: Zachary A.
  full_name: Schaaf, Zachary A.
  last_name: Schaaf
- first_name: Lyvin
  full_name: Tat, Lyvin
  last_name: Tat
- first_name: Noemi
  full_name: Cannizzaro, Noemi
  last_name: Cannizzaro
- first_name: Ralph
  full_name: Green, Ralph
  last_name: Green
- first_name: Thomas
  full_name: Rülicke, Thomas
  last_name: Rülicke
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: Konstantinos S.
  full_name: Zarbalis, Konstantinos S.
  last_name: Zarbalis
citation:
  ama: Schaaf ZA, Tat L, Cannizzaro N, et al. WDFY3 mutation alters laminar position
    and morphology of cortical neurons. <i>Molecular Autism</i>. 2022;13. doi:<a href="https://doi.org/10.1186/s13229-022-00508-3">10.1186/s13229-022-00508-3</a>
  apa: Schaaf, Z. A., Tat, L., Cannizzaro, N., Green, R., Rülicke, T., Hippenmeyer,
    S., &#38; Zarbalis, K. S. (2022). WDFY3 mutation alters laminar position and morphology
    of cortical neurons. <i>Molecular Autism</i>. Springer Nature. <a href="https://doi.org/10.1186/s13229-022-00508-3">https://doi.org/10.1186/s13229-022-00508-3</a>
  chicago: Schaaf, Zachary A., Lyvin Tat, Noemi Cannizzaro, Ralph Green, Thomas Rülicke,
    Simon Hippenmeyer, and Konstantinos S. Zarbalis. “WDFY3 Mutation Alters Laminar
    Position and Morphology of Cortical Neurons.” <i>Molecular Autism</i>. Springer
    Nature, 2022. <a href="https://doi.org/10.1186/s13229-022-00508-3">https://doi.org/10.1186/s13229-022-00508-3</a>.
  ieee: Z. A. Schaaf <i>et al.</i>, “WDFY3 mutation alters laminar position and morphology
    of cortical neurons,” <i>Molecular Autism</i>, vol. 13. Springer Nature, 2022.
  ista: Schaaf ZA, Tat L, Cannizzaro N, Green R, Rülicke T, Hippenmeyer S, Zarbalis
    KS. 2022. WDFY3 mutation alters laminar position and morphology of cortical neurons.
    Molecular Autism. 13, 27.
  mla: Schaaf, Zachary A., et al. “WDFY3 Mutation Alters Laminar Position and Morphology
    of Cortical Neurons.” <i>Molecular Autism</i>, vol. 13, 27, Springer Nature, 2022,
    doi:<a href="https://doi.org/10.1186/s13229-022-00508-3">10.1186/s13229-022-00508-3</a>.
  short: Z.A. Schaaf, L. Tat, N. Cannizzaro, R. Green, T. Rülicke, S. Hippenmeyer,
    K.S. Zarbalis, Molecular Autism 13 (2022).
date_created: 2022-06-23T14:28:55Z
date_published: 2022-06-22T00:00:00Z
date_updated: 2025-06-11T13:34:57Z
day: '22'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1186/s13229-022-00508-3
external_id:
  isi:
  - '000814641400001'
  pmid:
  - '35733184'
file:
- access_level: open_access
  checksum: 525d2618e855139089bbfc3e3d49d1b2
  content_type: application/pdf
  creator: dernst
  date_created: 2022-06-24T08:22:59Z
  date_updated: 2022-06-24T08:22:59Z
  file_id: '11461'
  file_name: 2022_MolecularAutism_Schaaf.pdf
  file_size: 7552298
  relation: main_file
  success: 1
file_date_updated: 2022-06-24T08:22:59Z
has_accepted_license: '1'
intvolume: '        13'
isi: 1
keyword:
- Psychiatry and Mental health
- Developmental Biology
- Developmental Neuroscience
- Molecular Biology
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
publication: Molecular Autism
publication_identifier:
  issn:
  - 2040-2392
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - relation: erratum
    url: https://doi.org/10.1186/s13229-023-00539-4
scopus_import: '1'
status: public
title: WDFY3 mutation alters laminar position and morphology of cortical neurons
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2022'
...
---
_id: '11462'
abstract:
- lang: eng
  text: Nanobodies (VHH) from camelid antibody libraries hold great promise as therapeutic
    agents and components of immunoassay systems. Synthetic antibody libraries that
    could be designed and generated once and for various applications could yield
    binders to virtually any targets, even for non-immunogenic or toxic ones, in a
    short term. One of the most difficult tasks is to obtain antibodies with a high
    affinity and specificity to polyglycosylated proteins. It requires antibody libraries
    with extremely high functional diversity and the use of sophisticated selection
    techniques. Here we report a development of a novel sandwich immunoassay involving
    a combination of the synthetic library-derived VHH-Fc fusion protein as a capture
    antibody and the immune single-chain fragment variable (scFv) as a tracer for
    the detection of pregnancy-associated glycoprotein (PAG) of cattle (Bos taurus).
    We succeeded in the generation of a number of specific scFv antibodies against
    PAG from the mouse immune library. Subsequent selection using the immobilized
    scFv-Fc capture antibody allowed to isolate 1.9 nM VHH binder from the diverse
    synthetic library without any overlapping with the capture antibody binding site.
    The prototype sandwich ELISA based on the synthetic VHH and the immune scFv was
    established. This is the first successful example of the combination of synthetic
    and immune antibody libraries in a single sandwich immunoassay. Thus, our approach
    could be used for the express isolation of antibody pairs and the development
    of sandwich immunoassays for challenging antigens.
acknowledgement: This study was financially supported by the State Committee on Science
  and Technology. We would like to thank Elena Tumar and Elena Kisileva at the Institute
  of Bioorganic Chemistry of NASB for their kind assistance with mouse immunizations.
article_processing_charge: No
article_type: original
author:
- first_name: Dmitri
  full_name: Dormeshkin, Dmitri
  last_name: Dormeshkin
- first_name: Michail
  full_name: Shapira, Michail
  last_name: Shapira
- first_name: Alena
  full_name: Karputs, Alena
  last_name: Karputs
- first_name: Anton
  full_name: Kavaleuski, Anton
  id: 62304f89-eb97-11eb-a6c2-8903dd183976
  last_name: Kavaleuski
  orcid: 0000-0003-2091-526X
- first_name: Ivan
  full_name: Kuzminski, Ivan
  last_name: Kuzminski
- first_name: Elena
  full_name: Stepanova, Elena
  last_name: Stepanova
- first_name: Andrei
  full_name: Gilep, Andrei
  last_name: Gilep
citation:
  ama: Dormeshkin D, Shapira M, Karputs A, et al. Combining of synthetic VHH and immune
    scFv libraries for pregnancy-associated glycoproteins ELISA development. <i>Applied
    Microbiology and Biotechnology</i>. 2022;106:5093-5103. doi:<a href="https://doi.org/10.1007/s00253-022-12022-w">10.1007/s00253-022-12022-w</a>
  apa: Dormeshkin, D., Shapira, M., Karputs, A., Kavaleuski, A., Kuzminski, I., Stepanova,
    E., &#38; Gilep, A. (2022). Combining of synthetic VHH and immune scFv libraries
    for pregnancy-associated glycoproteins ELISA development. <i>Applied Microbiology
    and Biotechnology</i>. Springer Nature. <a href="https://doi.org/10.1007/s00253-022-12022-w">https://doi.org/10.1007/s00253-022-12022-w</a>
  chicago: Dormeshkin, Dmitri, Michail Shapira, Alena Karputs, Anton Kavaleuski, Ivan
    Kuzminski, Elena Stepanova, and Andrei Gilep. “Combining of Synthetic VHH and
    Immune ScFv Libraries for Pregnancy-Associated Glycoproteins ELISA Development.”
    <i>Applied Microbiology and Biotechnology</i>. Springer Nature, 2022. <a href="https://doi.org/10.1007/s00253-022-12022-w">https://doi.org/10.1007/s00253-022-12022-w</a>.
  ieee: D. Dormeshkin <i>et al.</i>, “Combining of synthetic VHH and immune scFv libraries
    for pregnancy-associated glycoproteins ELISA development,” <i>Applied Microbiology
    and Biotechnology</i>, vol. 106. Springer Nature, pp. 5093–5103, 2022.
  ista: Dormeshkin D, Shapira M, Karputs A, Kavaleuski A, Kuzminski I, Stepanova E,
    Gilep A. 2022. Combining of synthetic VHH and immune scFv libraries for pregnancy-associated
    glycoproteins ELISA development. Applied Microbiology and Biotechnology. 106,
    5093–5103.
  mla: Dormeshkin, Dmitri, et al. “Combining of Synthetic VHH and Immune ScFv Libraries
    for Pregnancy-Associated Glycoproteins ELISA Development.” <i>Applied Microbiology
    and Biotechnology</i>, vol. 106, Springer Nature, 2022, pp. 5093–103, doi:<a href="https://doi.org/10.1007/s00253-022-12022-w">10.1007/s00253-022-12022-w</a>.
  short: D. Dormeshkin, M. Shapira, A. Karputs, A. Kavaleuski, I. Kuzminski, E. Stepanova,
    A. Gilep, Applied Microbiology and Biotechnology 106 (2022) 5093–5103.
date_created: 2022-06-26T22:01:34Z
date_published: 2022-08-01T00:00:00Z
date_updated: 2023-10-10T07:15:02Z
day: '01'
department:
- _id: GradSch
- _id: LeSa
doi: 10.1007/s00253-022-12022-w
external_id:
  isi:
  - '000813677500001'
  pmid:
  - '35723693'
intvolume: '       106'
isi: 1
language:
- iso: eng
month: '08'
oa_version: None
page: 5093-5103
pmid: 1
publication: Applied Microbiology and Biotechnology
publication_identifier:
  eissn:
  - 1432-0614
  issn:
  - 0175-7598
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Combining of synthetic VHH and immune scFv libraries for pregnancy-associated
  glycoproteins ELISA development
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 106
year: '2022'
...
---
_id: '11469'
abstract:
- lang: eng
  text: Thermalizing and localized many-body quantum systems present two distinct
    dynamical phases of matter. Recently the fate of a localized system coupled to
    a thermalizing system viewed as a quantum bath received significant theoretical
    and experimental attention. In this work, we study a mobile impurity, representing
    a small quantum bath, that interacts locally with an Anderson insulator with a
    finite density of localized particles. Using static Hartree approximation to obtain
    an effective disorder strength, we formulate an analytic criterion for the perturbative
    stability of the localization. Next, we use an approximate dynamical Hartree method
    and the quasi-exact time-evolved block decimation (TEBD) algorithm to study the
    dynamics of the system. We find that the dynamical Hartree approach which completely
    ignores entanglement between the impurity and localized particles predicts the
    delocalization of the system. In contrast, the full numerical simulation of the
    unitary dynamics with TEBD suggests the stability of localization on numerically
    accessible timescales. Finally, using an extension of the density matrix renormalization
    group algorithm to excited states (DMRG-X), we approximate the highly excited
    eigenstates of the system. We find that the impurity remains localized in the
    eigenstates and entanglement is enhanced in a finite region around the position
    of the impurity, confirming the dynamical predictions. Dynamics and the DMRG-X
    results provide compelling evidence for the stability of localization.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: We thank M. Ljubotina for insightful discussions. P. B., A. M. and
  M. S. acknowledge support by the European Research Council (ERC) under the European
  Union’s Horizon 2020 research and innovation program (Grant Agreement No. 850899).
  D. A. was supported by the Swiss National Science Foundation and by the European
  Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
  program (Grant Agreement No. 864597). The development of parallel TEBD code was
  supported by S. Elefante from the Scientific Computing (SciComp) that is part of
  Scientific Service Units (SSU) of IST Austria. Some of the computations were performed
  on the Baobab cluster of the University of Geneva.
article_number: '224208'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Pietro
  full_name: Brighi, Pietro
  id: 4115AF5C-F248-11E8-B48F-1D18A9856A87
  last_name: Brighi
  orcid: 0000-0002-7969-2729
- first_name: Alexios
  full_name: Michailidis, Alexios
  id: 36EBAD38-F248-11E8-B48F-1D18A9856A87
  last_name: Michailidis
  orcid: 0000-0002-8443-1064
- first_name: Kristina
  full_name: Kirova, Kristina
  id: 4aeda2ae-f847-11ec-98e0-c4a66fe174d4
  last_name: Kirova
- first_name: Dmitry A.
  full_name: Abanin, Dmitry A.
  last_name: Abanin
- first_name: Maksym
  full_name: Serbyn, Maksym
  id: 47809E7E-F248-11E8-B48F-1D18A9856A87
  last_name: Serbyn
  orcid: 0000-0002-2399-5827
citation:
  ama: Brighi P, Michailidis A, Kirova K, Abanin DA, Serbyn M. Localization of a mobile
    impurity interacting with an Anderson insulator. <i>Physical Review B</i>. 2022;105(22).
    doi:<a href="https://doi.org/10.1103/physrevb.105.224208">10.1103/physrevb.105.224208</a>
  apa: Brighi, P., Michailidis, A., Kirova, K., Abanin, D. A., &#38; Serbyn, M. (2022).
    Localization of a mobile impurity interacting with an Anderson insulator. <i>Physical
    Review B</i>. American Physical Society. <a href="https://doi.org/10.1103/physrevb.105.224208">https://doi.org/10.1103/physrevb.105.224208</a>
  chicago: Brighi, Pietro, Alexios Michailidis, Kristina Kirova, Dmitry A. Abanin,
    and Maksym Serbyn. “Localization of a Mobile Impurity Interacting with an Anderson
    Insulator.” <i>Physical Review B</i>. American Physical Society, 2022. <a href="https://doi.org/10.1103/physrevb.105.224208">https://doi.org/10.1103/physrevb.105.224208</a>.
  ieee: P. Brighi, A. Michailidis, K. Kirova, D. A. Abanin, and M. Serbyn, “Localization
    of a mobile impurity interacting with an Anderson insulator,” <i>Physical Review
    B</i>, vol. 105, no. 22. American Physical Society, 2022.
  ista: Brighi P, Michailidis A, Kirova K, Abanin DA, Serbyn M. 2022. Localization
    of a mobile impurity interacting with an Anderson insulator. Physical Review B.
    105(22), 224208.
  mla: Brighi, Pietro, et al. “Localization of a Mobile Impurity Interacting with
    an Anderson Insulator.” <i>Physical Review B</i>, vol. 105, no. 22, 224208, American
    Physical Society, 2022, doi:<a href="https://doi.org/10.1103/physrevb.105.224208">10.1103/physrevb.105.224208</a>.
  short: P. Brighi, A. Michailidis, K. Kirova, D.A. Abanin, M. Serbyn, Physical Review
    B 105 (2022).
corr_author: '1'
date_created: 2022-06-29T20:19:51Z
date_published: 2022-06-27T00:00:00Z
date_updated: 2026-04-07T13:26:31Z
day: '27'
department:
- _id: MaSe
doi: 10.1103/physrevb.105.224208
ec_funded: 1
external_id:
  arxiv:
  - '2111.08603'
  isi:
  - '000823050000001'
intvolume: '       105'
isi: 1
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: ' https://doi.org/10.48550/arXiv.2111.08603'
month: '06'
oa: 1
oa_version: Preprint
project:
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
  call_identifier: H2020
  grant_number: '850899'
  name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication: Physical Review B
publication_identifier:
  eissn:
  - 2469-9969
  issn:
  - 2469-9950
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
  record:
  - id: '12732'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Localization of a mobile impurity interacting with an Anderson insulator
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 105
year: '2022'
...
---
_id: '11470'
abstract:
- lang: eng
  text: Many-body localization (MBL) is an example of a dynamical phase of matter
    that avoids thermalization. While the MBL phase is robust to weak local perturbations,
    the fate of an MBL system coupled to a thermalizing quantum system that represents
    a “heat bath” is an open question that is actively investigated theoretically
    and experimentally. In this work, we consider the stability of an Anderson insulator
    with a finite density of particles interacting with a single mobile impurity—a
    small quantum bath. We give perturbative arguments that support the stability
    of localization in the strong interaction regime. Large-scale tensor network simulations
    of dynamics are employed to corroborate the presence of the localized phase and
    give quantitative predictions in the thermodynamic limit. We develop a phenomenological
    description of the dynamics in the strong interaction regime, and we demonstrate
    that the impurity effectively turns the Anderson insulator into an MBL phase,
    giving rise to nontrivial entanglement dynamics well captured by our phenomenology.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: We acknowledge useful discussions with M. Ljubotina. P. B., A. M.,
  and M. S. were supported by the European Research Council (ERC) under the European
  Union’s Horizon 2020 research and innovation program (Grant Agreement No. 850899).
  D.A. was supported by the Swiss National Science Foundation and by the European
  Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
  program (Grant Agreement No. 864597). The development of parallel TEBD code was
  was supported by S. Elefante from the Scientific Computing (SciComp) that is part
  of Scientific Service Units (SSU) of IST Austria. Some of the computations were
  performed on the Baobab cluster of the University of Geneva.
article_number: L220203
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Pietro
  full_name: Brighi, Pietro
  id: 4115AF5C-F248-11E8-B48F-1D18A9856A87
  last_name: Brighi
  orcid: 0000-0002-7969-2729
- first_name: Alexios A.
  full_name: Michailidis, Alexios A.
  last_name: Michailidis
- first_name: Dmitry A.
  full_name: Abanin, Dmitry A.
  last_name: Abanin
- first_name: Maksym
  full_name: Serbyn, Maksym
  id: 47809E7E-F248-11E8-B48F-1D18A9856A87
  last_name: Serbyn
  orcid: 0000-0002-2399-5827
citation:
  ama: Brighi P, Michailidis AA, Abanin DA, Serbyn M. Propagation of many-body localization
    in an Anderson insulator. <i>Physical Review B</i>. 2022;105(22). doi:<a href="https://doi.org/10.1103/physrevb.105.l220203">10.1103/physrevb.105.l220203</a>
  apa: Brighi, P., Michailidis, A. A., Abanin, D. A., &#38; Serbyn, M. (2022). Propagation
    of many-body localization in an Anderson insulator. <i>Physical Review B</i>.
    American Physical Society. <a href="https://doi.org/10.1103/physrevb.105.l220203">https://doi.org/10.1103/physrevb.105.l220203</a>
  chicago: Brighi, Pietro, Alexios A. Michailidis, Dmitry A. Abanin, and Maksym Serbyn.
    “Propagation of Many-Body Localization in an Anderson Insulator.” <i>Physical
    Review B</i>. American Physical Society, 2022. <a href="https://doi.org/10.1103/physrevb.105.l220203">https://doi.org/10.1103/physrevb.105.l220203</a>.
  ieee: P. Brighi, A. A. Michailidis, D. A. Abanin, and M. Serbyn, “Propagation of
    many-body localization in an Anderson insulator,” <i>Physical Review B</i>, vol.
    105, no. 22. American Physical Society, 2022.
  ista: Brighi P, Michailidis AA, Abanin DA, Serbyn M. 2022. Propagation of many-body
    localization in an Anderson insulator. Physical Review B. 105(22), L220203.
  mla: Brighi, Pietro, et al. “Propagation of Many-Body Localization in an Anderson
    Insulator.” <i>Physical Review B</i>, vol. 105, no. 22, L220203, American Physical
    Society, 2022, doi:<a href="https://doi.org/10.1103/physrevb.105.l220203">10.1103/physrevb.105.l220203</a>.
  short: P. Brighi, A.A. Michailidis, D.A. Abanin, M. Serbyn, Physical Review B 105
    (2022).
corr_author: '1'
date_created: 2022-06-29T20:20:47Z
date_published: 2022-06-27T00:00:00Z
date_updated: 2026-04-07T13:26:31Z
day: '27'
department:
- _id: MaSe
doi: 10.1103/physrevb.105.l220203
ec_funded: 1
external_id:
  arxiv:
  - '2109.07332'
  isi:
  - '000823050000012'
intvolume: '       105'
isi: 1
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: ' https://doi.org/10.48550/arXiv.2109.07332'
month: '06'
oa: 1
oa_version: Preprint
project:
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
  call_identifier: H2020
  grant_number: '850899'
  name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication: Physical Review B
publication_identifier:
  eissn:
  - 2469-9969
  issn:
  - 2469-9950
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
  record:
  - id: '12732'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Propagation of many-body localization in an Anderson insulator
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 105
year: '2022'
...
---
OA_place: publisher
_id: '11473'
abstract:
- lang: eng
  text: "The polaron model is a basic model of quantum field theory describing a single
    particle\r\ninteracting with a bosonic field. It arises in many physical contexts.
    We are mostly concerned\r\nwith models applicable in the context of an impurity
    atom in a Bose-Einstein condensate as\r\nwell as the problem of electrons moving
    in polar crystals.\r\nThe model has a simple structure in which the interaction
    of the particle with the field is given\r\nby a term linear in the field’s creation
    and annihilation operators. In this work, we investigate\r\nthe properties of
    this model by providing rigorous estimates on various energies relevant to the\r\nproblem.
    The estimates are obtained, for the most part, by suitable operator techniques
    which\r\nconstitute the principal mathematical substance of the thesis.\r\nThe
    first application of these techniques is to derive the polaron model rigorously
    from first\r\nprinciples, i.e., from a full microscopic quantum-mechanical many-body
    problem involving an\r\nimpurity in an otherwise homogeneous system. We accomplish
    this for the N + 1 Bose gas\r\nin the mean-field regime by showing that a suitable
    polaron-type Hamiltonian arises at weak\r\ninteractions as a low-energy effective
    theory for this problem.\r\nIn the second part, we investigate rigorously the
    ground state of the model at fixed momentum\r\nand for large values of the coupling
    constant. Qualitatively, the system is expected to display\r\na transition from
    the quasi-particle behavior at small momenta, where the dispersion relation\r\nis
    parabolic and the particle moves through the medium dragging along a cloud of
    phonons, to\r\nthe radiative behavior at larger momenta where the polaron decelerates
    and emits free phonons.\r\nAt the same time, in the strong coupling regime, the
    bosonic field is expected to behave purely\r\nclassically. Accordingly, the effective
    mass of the polaron at strong coupling is conjectured to\r\nbe asymptotically
    equal to the one obtained from the semiclassical counterpart of the problem,\r\nfirst
    studied by Landau and Pekar in the 1940s. For polaron models with regularized
    form\r\nfactors and phonon dispersion relations of superfluid type, i.e., bounded
    below by a linear\r\nfunction of the wavenumbers for all phonon momenta as in
    the interacting Bose gas, we prove\r\nthat for a large window of momenta below
    the radiation threshold, the energy-momentum\r\nrelation at strong coupling is
    indeed essentially a parabola with semi-latus rectum equal to the\r\nLandau–Pekar
    effective mass, as expected.\r\nFor the Fröhlich polaron describing electrons
    in polar crystals where the dispersion relation is\r\nof the optical type and
    the form factor is formally UV–singular due to the nature of the point\r\ncharge-dipole
    interaction, we are able to give the corresponding upper bound. In contrast to\r\nthe
    regular case, this requires the inclusion of the quantum fluctuations of the phonon
    field,\r\nwhich makes the problem considerably more difficult.\r\nThe results
    are supplemented by studies on the absolute ground-state energy at strong coupling,\r\na
    proof of the divergence of the effective mass with the coupling constant for a
    wide class of\r\npolaron models, as well as the discussion of the apparent UV
    singularity of the Fröhlich model\r\nand the application of the techniques used
    for its removal for the energy estimates.\r\n"
acknowledged_ssus:
- _id: SSU
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Krzysztof
  full_name: Mysliwy, Krzysztof
  id: 316457FC-F248-11E8-B48F-1D18A9856A87
  last_name: Mysliwy
citation:
  ama: 'Mysliwy K. Polarons in Bose gases and polar crystals: Some rigorous energy
    estimates. 2022. doi:<a href="https://doi.org/10.15479/at:ista:11473">10.15479/at:ista:11473</a>'
  apa: 'Mysliwy, K. (2022). <i>Polarons in Bose gases and polar crystals: Some rigorous
    energy estimates</i>. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/at:ista:11473">https://doi.org/10.15479/at:ista:11473</a>'
  chicago: 'Mysliwy, Krzysztof. “Polarons in Bose Gases and Polar Crystals: Some Rigorous
    Energy Estimates.” Institute of Science and Technology Austria, 2022. <a href="https://doi.org/10.15479/at:ista:11473">https://doi.org/10.15479/at:ista:11473</a>.'
  ieee: 'K. Mysliwy, “Polarons in Bose gases and polar crystals: Some rigorous energy
    estimates,” Institute of Science and Technology Austria, 2022.'
  ista: 'Mysliwy K. 2022. Polarons in Bose gases and polar crystals: Some rigorous
    energy estimates. Institute of Science and Technology Austria.'
  mla: 'Mysliwy, Krzysztof. <i>Polarons in Bose Gases and Polar Crystals: Some Rigorous
    Energy Estimates</i>. Institute of Science and Technology Austria, 2022, doi:<a
    href="https://doi.org/10.15479/at:ista:11473">10.15479/at:ista:11473</a>.'
  short: 'K. Mysliwy, Polarons in Bose Gases and Polar Crystals: Some Rigorous Energy
    Estimates, Institute of Science and Technology Austria, 2022.'
corr_author: '1'
date_created: 2022-06-30T12:15:03Z
date_published: 2022-07-01T00:00:00Z
date_updated: 2026-04-07T14:14:52Z
day: '01'
ddc:
- '515'
- '539'
degree_awarded: PhD
department:
- _id: GradSch
- _id: RoSe
doi: 10.15479/at:ista:11473
ec_funded: 1
file:
- access_level: open_access
  checksum: 7970714a20a6052f75fb27a6c3e9976e
  content_type: application/pdf
  creator: kmysliwy
  date_created: 2022-07-05T08:12:56Z
  date_updated: 2022-07-05T08:12:56Z
  file_id: '11486'
  file_name: thes1_no_isbn_2_1b.pdf
  file_size: 1830973
  relation: main_file
  success: 1
- access_level: closed
  checksum: 647a2011fdf56277096c9350fefe1097
  content_type: application/zip
  creator: kmysliwy
  date_created: 2022-07-05T08:15:52Z
  date_updated: 2022-07-05T08:17:12Z
  file_id: '11487'
  file_name: thes_source.zip
  file_size: 5831060
  relation: source_file
file_date_updated: 2022-07-05T08:17:12Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '138'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '10564'
    relation: part_of_dissertation
    status: public
  - id: '8705'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Robert
  full_name: Seiringer, Robert
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
title: 'Polarons in Bose gases and polar crystals: Some rigorous energy estimates'
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2022'
...
---
_id: '11476'
abstract:
- lang: eng
  text: "Messaging platforms like Signal are widely deployed and provide strong security
    in an asynchronous setting. It is a challenging problem to construct a protocol
    with similar security guarantees that can efficiently scale to large groups. A
    major bottleneck are the frequent key rotations users need to perform to achieve
    post compromise forward security.\r\n\r\nIn current proposals – most notably in
    TreeKEM (which is part of the IETF’s Messaging Layer Security (MLS) protocol draft)
    – for users in a group of size n to rotate their keys, they must each craft a
    message of size log(n) to be broadcast to the group using an (untrusted) delivery
    server.\r\n\r\nIn larger groups, having users sequentially rotate their keys requires
    too much bandwidth (or takes too long), so variants allowing any T≤n users to
    simultaneously rotate their keys in just 2 communication rounds have been suggested
    (e.g. “Propose and Commit” by MLS). Unfortunately, 2-round concurrent updates
    are either damaging or expensive (or both); i.e. they either result in future
    operations being more costly (e.g. via “blanking” or “tainting”) or are costly
    themselves requiring Ω(T) communication for each user [Bienstock et al., TCC’20].\r\n\r\nIn
    this paper we propose CoCoA; a new scheme that allows for T concurrent updates
    that are neither damaging nor costly. That is, they add no cost to future operations
    yet they only require Ω(log2(n)) communication per user. To circumvent the [Bienstock
    et al.] lower bound, CoCoA increases the number of rounds needed to complete all
    updates from 2 up to (at most) log(n); though typically fewer rounds are needed.\r\n\r\nThe
    key insight of our protocol is the following: in the (non-concurrent version of)
    TreeKEM, a delivery server which gets T concurrent update requests will approve
    one and reject the remaining T−1. In contrast, our server attempts to apply all
    of them. If more than one user requests to rotate the same key during a round,
    the server arbitrarily picks a winner. Surprisingly, we prove that regardless
    of how the server chooses the winners, all previously compromised users will recover
    after at most log(n) such update rounds.\r\n\r\nTo keep the communication complexity
    low, CoCoA is a server-aided CGKA. That is, the delivery server no longer blindly
    forwards packets, but instead actively computes individualized packets tailored
    to each user. As the server is untrusted, this change requires us to develop new
    mechanisms ensuring robustness of the protocol."
acknowledgement: We thank Marta Mularczyk and Yiannis Tselekounis for their very helpful
  feedback on an earlier draft of this paper.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Joël
  full_name: Alwen, Joël
  last_name: Alwen
- first_name: Benedikt
  full_name: Auerbach, Benedikt
  id: D33D2B18-E445-11E9-ABB7-15F4E5697425
  last_name: Auerbach
  orcid: 0000-0002-7553-6606
- first_name: Miguel
  full_name: Cueto Noval, Miguel
  id: ffc563a3-f6e0-11ea-865d-e3cce03d17cc
  last_name: Cueto Noval
  orcid: 0000-0002-2505-4246
- first_name: Karen
  full_name: Klein, Karen
  id: 3E83A2F8-F248-11E8-B48F-1D18A9856A87
  last_name: Klein
- first_name: Guillermo
  full_name: Pascual Perez, Guillermo
  id: 2D7ABD02-F248-11E8-B48F-1D18A9856A87
  last_name: Pascual Perez
  orcid: 0000-0001-8630-415X
- first_name: Krzysztof Z
  full_name: Pietrzak, Krzysztof Z
  id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
  last_name: Pietrzak
  orcid: 0000-0002-9139-1654
- first_name: Michael
  full_name: Walter, Michael
  last_name: Walter
citation:
  ama: 'Alwen J, Auerbach B, Cueto Noval M, et al. CoCoA: Concurrent continuous group
    key agreement. In: <i>Advances in Cryptology – EUROCRYPT 2022</i>. Vol 13276.
    Cham: Springer Nature; 2022:815–844. doi:<a href="https://doi.org/10.1007/978-3-031-07085-3_28">10.1007/978-3-031-07085-3_28</a>'
  apa: 'Alwen, J., Auerbach, B., Cueto Noval, M., Klein, K., Pascual Perez, G., Pietrzak,
    K. Z., &#38; Walter, M. (2022). CoCoA: Concurrent continuous group key agreement.
    In <i>Advances in Cryptology – EUROCRYPT 2022</i> (Vol. 13276, pp. 815–844). Cham:
    Springer Nature. <a href="https://doi.org/10.1007/978-3-031-07085-3_28">https://doi.org/10.1007/978-3-031-07085-3_28</a>'
  chicago: 'Alwen, Joël, Benedikt Auerbach, Miguel Cueto Noval, Karen Klein, Guillermo
    Pascual Perez, Krzysztof Z Pietrzak, and Michael Walter. “CoCoA: Concurrent Continuous
    Group Key Agreement.” In <i>Advances in Cryptology – EUROCRYPT 2022</i>, 13276:815–844.
    Cham: Springer Nature, 2022. <a href="https://doi.org/10.1007/978-3-031-07085-3_28">https://doi.org/10.1007/978-3-031-07085-3_28</a>.'
  ieee: 'J. Alwen <i>et al.</i>, “CoCoA: Concurrent continuous group key agreement,”
    in <i>Advances in Cryptology – EUROCRYPT 2022</i>, Trondheim, Norway, 2022, vol.
    13276, pp. 815–844.'
  ista: 'Alwen J, Auerbach B, Cueto Noval M, Klein K, Pascual Perez G, Pietrzak KZ,
    Walter M. 2022. CoCoA: Concurrent continuous group key agreement. Advances in
    Cryptology – EUROCRYPT 2022. EUROCRYPT: Theory and Applications of Cryptology
    and Information Security, LNCS, vol. 13276, 815–844.'
  mla: 'Alwen, Joël, et al. “CoCoA: Concurrent Continuous Group Key Agreement.” <i>Advances
    in Cryptology – EUROCRYPT 2022</i>, vol. 13276, Springer Nature, 2022, pp. 815–844,
    doi:<a href="https://doi.org/10.1007/978-3-031-07085-3_28">10.1007/978-3-031-07085-3_28</a>.'
  short: J. Alwen, B. Auerbach, M. Cueto Noval, K. Klein, G. Pascual Perez, K.Z. Pietrzak,
    M. Walter, in:, Advances in Cryptology – EUROCRYPT 2022, Springer Nature, Cham,
    2022, pp. 815–844.
conference:
  end_date: 2022-06-03
  location: Trondheim, Norway
  name: 'EUROCRYPT: Theory and Applications of Cryptology and Information Security'
  start_date: 2022-05-30
corr_author: '1'
date_created: 2022-06-30T16:48:00Z
date_published: 2022-05-25T00:00:00Z
date_updated: 2026-04-07T13:01:26Z
day: '25'
department:
- _id: GradSch
- _id: KrPi
doi: 10.1007/978-3-031-07085-3_28
ec_funded: 1
external_id:
  isi:
  - '000832305300028'
intvolume: '     13276'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://eprint.iacr.org/2022/251
month: '05'
oa: 1
oa_version: Preprint
page: 815–844
place: Cham
project:
- _id: 258AA5B2-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '682815'
  name: Teaching Old Crypto New Tricks
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication: Advances in Cryptology – EUROCRYPT 2022
publication_identifier:
  eisbn:
  - '9783031070853'
  eissn:
  - 1611-3349
  isbn:
  - '9783031070846'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  record:
  - id: '18088'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: 'CoCoA: Concurrent continuous group key agreement'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13276
year: '2022'
...
---
_id: '11488'
abstract:
- lang: eng
  text: Hydrogen Lyα haloes (LAHs) are commonly used as a tracer of the circumgalactic
    medium (CGM) at high redshifts. In this work, we aim to explore the existence
    of Lyα haloes around individual UV-selected galaxies, rather than around Lyα emitters
    (LAEs), at high redshifts. Our sample was continuum-selected with F775W ≤ 27.5,
    and spectroscopic redshifts were assigned or constrained for all the sources thanks
    to the deepest (100- to 140-h) existing Very Large Telescope (VLT)/Multi-Unit
    Spectroscopic Explorer (MUSE) data with adaptive optics. The final sample includes
    21 galaxies that are purely F775W-magnitude selected within the redshift range
    z ≈ 2.9 − 4.4 and within a UV magnitude range −20 ≤ M1500 ≤ −18, thus avoiding
    any bias toward LAEs. We tested whether galaxy’s Lyα emission is significantly
    more extended than the MUSE PSF-convolved continuum component. We find 17 LAHs
    and four non-LAHs. We report the first individual detections of extended Lyα emission
    around non-LAEs. The Lyα halo fraction is thus as high as 81.0−11.2+10.3%, which
    is close to that for LAEs at z = 3 − 6 in the literature. This implies that UV-selected
    galaxies generally have a large amount of hydrogen in their CGM. We derived the
    mean surface brightness (SB) profile for our LAHs with cosmic dimming corrections
    and find that Lyα emission extends to 5.4 arcsec (≃40 physical kpc at the midpoint
    redshift z = 3.6) above the typical 1σ SB limit. The incidence rate of surrounding
    gas detected in Lyα per one-dimensional line of sight per unit redshift, dn/dz,
    is estimated to be 0.76−0.09+0.09 for galaxies with M1500 ≤ −18 mag at z ≃ 3.7.
    Assuming that Lyα emission and absorption arise in the same gas, this suggests,
    based on abundance matching, that LAHs trace the same gas as damped Lyα systems
    (DLAs) and sub-DLAs.
acknowledgement: 'We thank the anonymous referee for constructive comments and suggestions.
  We would like to express our gratitude to Edmund Christian Herenz, Leindert Boogard,
  Miroslava Dessauges, Moupiya Maji, Valentin Mauerhofer, Charlotte Paola Simmonds
  Wagemann, Masami Ouchi, Kazuhiro Shimasaku, Akio Inoue, and Rieko Momose for giving
  insightful comments and suggestions. H.K. is grateful to Liam McCarney for useful
  suggestions on English writing through the UniGE’s Tandems linguistiques. H.K. acknowledges
  support from Swiss Government Excellence Scholarships and Japan Society for the
  Promotion of Science (JSPS) Overseas Research Fellowship. H.K., F.L., and A.V. are
  supported by the SNF grant PP00P2 176808. A.V. and T.G. are supported by the ERC
  Starting Grant 757258“TRIPLE”. This work was supported by the Programme National
  Cosmology et Galaxies (PNCG) of CNRS/INSU with INP and IN2P3, co-funded by CEA and
  CNES. This work is based on observations taken by VLT, which is operated by European
  Southern Observatory. This research made use of Astropy, which is a community-developed
  core Python package for Astronomy (Astropy Collaboration 2013, 2018), and other
  software and packages: MARZ, MPDAF (Piqueras et al. 2019), PHOTUTILS, Numpy (Harris
  et al. 2020), Scipy (Virtanen et al. 2020), and matplotlib (Hunter 2007).'
article_number: A44
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Haruka
  full_name: Kusakabe, Haruka
  last_name: Kusakabe
- first_name: Anne
  full_name: Verhamme, Anne
  last_name: Verhamme
- first_name: Jérémy
  full_name: Blaizot, Jérémy
  last_name: Blaizot
- first_name: Thibault
  full_name: Garel, Thibault
  last_name: Garel
- first_name: Lutz
  full_name: Wisotzki, Lutz
  last_name: Wisotzki
- first_name: Floriane
  full_name: Leclercq, Floriane
  last_name: Leclercq
- first_name: Roland
  full_name: Bacon, Roland
  last_name: Bacon
- first_name: Joop
  full_name: Schaye, Joop
  last_name: Schaye
- first_name: Sofia G.
  full_name: Gallego, Sofia G.
  last_name: Gallego
- first_name: Josephine
  full_name: Kerutt, Josephine
  last_name: Kerutt
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
- first_name: Michael
  full_name: Maseda, Michael
  last_name: Maseda
- first_name: Themiya
  full_name: Nanayakkara, Themiya
  last_name: Nanayakkara
- first_name: Roser
  full_name: Pelló, Roser
  last_name: Pelló
- first_name: Johan
  full_name: Richard, Johan
  last_name: Richard
- first_name: Laurence
  full_name: Tresse, Laurence
  last_name: Tresse
- first_name: Tanya
  full_name: Urrutia, Tanya
  last_name: Urrutia
- first_name: Eloïse
  full_name: Vitte, Eloïse
  last_name: Vitte
citation:
  ama: 'Kusakabe H, Verhamme A, Blaizot J, et al. The MUSE eXtremely Deep Field: Individual
    detections of Ly<i>α</i> haloes around rest-frame UV-selected galaxies at <i>z</i>
    ≃ 2.9–4.4. <i>Astronomy &#38; Astrophysics</i>. 2022;660. doi:<a href="https://doi.org/10.1051/0004-6361/202142302">10.1051/0004-6361/202142302</a>'
  apa: 'Kusakabe, H., Verhamme, A., Blaizot, J., Garel, T., Wisotzki, L., Leclercq,
    F., … Vitte, E. (2022). The MUSE eXtremely Deep Field: Individual detections of
    Ly<i>α</i> haloes around rest-frame UV-selected galaxies at <i>z</i> ≃ 2.9–4.4.
    <i>Astronomy &#38; Astrophysics</i>. EDP Sciences. <a href="https://doi.org/10.1051/0004-6361/202142302">https://doi.org/10.1051/0004-6361/202142302</a>'
  chicago: 'Kusakabe, Haruka, Anne Verhamme, Jérémy Blaizot, Thibault Garel, Lutz
    Wisotzki, Floriane Leclercq, Roland Bacon, et al. “The MUSE EXtremely Deep Field:
    Individual Detections of Ly<i>α</i> Haloes around Rest-Frame UV-Selected Galaxies
    at <i>z</i> ≃ 2.9–4.4.” <i>Astronomy &#38; Astrophysics</i>. EDP Sciences, 2022.
    <a href="https://doi.org/10.1051/0004-6361/202142302">https://doi.org/10.1051/0004-6361/202142302</a>.'
  ieee: 'H. Kusakabe <i>et al.</i>, “The MUSE eXtremely Deep Field: Individual detections
    of Ly<i>α</i> haloes around rest-frame UV-selected galaxies at <i>z</i> ≃ 2.9–4.4,”
    <i>Astronomy &#38; Astrophysics</i>, vol. 660. EDP Sciences, 2022.'
  ista: 'Kusakabe H, Verhamme A, Blaizot J, Garel T, Wisotzki L, Leclercq F, Bacon
    R, Schaye J, Gallego SG, Kerutt J, Matthee JJ, Maseda M, Nanayakkara T, Pelló
    R, Richard J, Tresse L, Urrutia T, Vitte E. 2022. The MUSE eXtremely Deep Field:
    Individual detections of Ly<i>α</i> haloes around rest-frame UV-selected galaxies
    at <i>z</i> ≃ 2.9–4.4. Astronomy &#38; Astrophysics. 660, A44.'
  mla: 'Kusakabe, Haruka, et al. “The MUSE EXtremely Deep Field: Individual Detections
    of Ly<i>α</i> Haloes around Rest-Frame UV-Selected Galaxies at <i>z</i> ≃ 2.9–4.4.”
    <i>Astronomy &#38; Astrophysics</i>, vol. 660, A44, EDP Sciences, 2022, doi:<a
    href="https://doi.org/10.1051/0004-6361/202142302">10.1051/0004-6361/202142302</a>.'
  short: H. Kusakabe, A. Verhamme, J. Blaizot, T. Garel, L. Wisotzki, F. Leclercq,
    R. Bacon, J. Schaye, S.G. Gallego, J. Kerutt, J.J. Matthee, M. Maseda, T. Nanayakkara,
    R. Pelló, J. Richard, L. Tresse, T. Urrutia, E. Vitte, Astronomy &#38; Astrophysics
    660 (2022).
date_created: 2022-07-05T14:27:26Z
date_published: 2022-04-07T00:00:00Z
date_updated: 2022-07-19T09:33:24Z
day: '07'
doi: 10.1051/0004-6361/202142302
extern: '1'
external_id:
  arxiv:
  - '2201.07257'
intvolume: '       660'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: high-redshift / galaxies: formation / galaxies: evolution / cosmology:
  observations'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2201.07257
month: '04'
oa: 1
oa_version: Published Version
publication: Astronomy & Astrophysics
publication_identifier:
  eissn:
  - 1432-0746
  issn:
  - 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The MUSE eXtremely Deep Field: Individual detections of Ly<i>α</i> haloes
  around rest-frame UV-selected galaxies at <i>z</i> ≃ 2.9–4.4'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 660
year: '2022'
...
---
_id: '11489'
abstract:
- lang: eng
  text: Much of plant development depends on cell-to-cell redistribution of the plant
    hormone auxin, which is facilitated by the plasma membrane (PM) localized PIN
    FORMED (PIN) proteins. Auxin export activity, developmental roles, subcellular
    trafficking, and polarity of PINs have been well studied, but their structure
    remains elusive besides a rough outline that they contain two groups of 5 alpha-helices
    connected by a large hydrophilic loop (HL). Here, we focus on the PIN1 HL as we
    could produce it in sufficient quantities for biochemical investigations to provide
    insights into its secondary structure. Circular dichroism (CD) studies revealed
    its nature as an intrinsically disordered protein (IDP), manifested by the increase
    of structure content upon thermal melting. Consistent with IDPs serving as interaction
    platforms, PIN1 loops homodimerize. PIN1 HL cytoplasmic overexpression in Arabidopsis
    disrupts early endocytic trafficking of PIN1 and PIN2 and causes defects in the
    cotyledon vasculature formation. In summary, we demonstrate that PIN1 HL has an
    intrinsically disordered nature, which must be considered to gain further structural
    insights. Some secondary structures may form transiently during pairing with known
    and yet-to-be-discovered interactors.
acknowledgement: 'We thank Charo del Genio from Coventry University and Richard Napier
  from the University of Warwick for helpful discussion concerning protein modeling
  and inspiration concerning CD spectroscopy, respectively. We thank Jan Hejatko for
  sharing the published AHP2 construct. We also thank Josef Houser from the core facility
  BIC CEITEC for valuable assistance, discussions, and ideas relating to CD. We acknowledge
  the: Core Facility CELLIM of CEITEC supported by the Czech-BioImaging large RI project
  (LM2018129 funded by MEYS CR), part of the Euro-BioImaging (www.eurobioimaging.eu
  accessed on 1 January 2016) ALM and medical imaging Node (Brno, CZ), CF Biomolecular
  Interactions and Crystallization of CIISB, Instruct-CZ Centre, supported by MEYS
  CR (LM2018127) and European Regional Development Fund-Project “UP CIISB“ (No. CZ.02.1.01/0.0/0.0/18_046/0015974)
  for their support with obtaining scientific data presented in this paper; Plant
  Sciences Core Facility of CEITEC Masaryk University for technical support. Open
  Access Funding by the Austrian Science Fund (FWF).'
article_processing_charge: Yes
article_type: original
author:
- first_name: V
  full_name: Bilanovičová, V
  last_name: Bilanovičová
- first_name: N
  full_name: Rýdza, N
  last_name: Rýdza
- first_name: L
  full_name: Koczka, L
  last_name: Koczka
- first_name: M
  full_name: Hess, M
  last_name: Hess
- first_name: E
  full_name: Feraru, E
  last_name: Feraru
- first_name: Jiří
  full_name: Friml, Jiří
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: T
  full_name: Nodzyński, T
  last_name: Nodzyński
citation:
  ama: Bilanovičová V, Rýdza N, Koczka L, et al. The hydrophilic loop of Arabidopsis
    PIN1 auxin efflux carrier harbors hallmarks of an intrinsically disordered protein.
    <i>International Journal of Molecular Sciences</i>. 2022;23(11):6352. doi:<a href="https://doi.org/10.3390/ijms23116352">10.3390/ijms23116352</a>
  apa: Bilanovičová, V., Rýdza, N., Koczka, L., Hess, M., Feraru, E., Friml, J., &#38;
    Nodzyński, T. (2022). The hydrophilic loop of Arabidopsis PIN1 auxin efflux carrier
    harbors hallmarks of an intrinsically disordered protein. <i>International Journal
    of Molecular Sciences</i>. MDPI. <a href="https://doi.org/10.3390/ijms23116352">https://doi.org/10.3390/ijms23116352</a>
  chicago: Bilanovičová, V, N Rýdza, L Koczka, M Hess, E Feraru, Jiří Friml, and T
    Nodzyński. “The Hydrophilic Loop of Arabidopsis PIN1 Auxin Efflux Carrier Harbors
    Hallmarks of an Intrinsically Disordered Protein.” <i>International Journal of
    Molecular Sciences</i>. MDPI, 2022. <a href="https://doi.org/10.3390/ijms23116352">https://doi.org/10.3390/ijms23116352</a>.
  ieee: V. Bilanovičová <i>et al.</i>, “The hydrophilic loop of Arabidopsis PIN1 auxin
    efflux carrier harbors hallmarks of an intrinsically disordered protein,” <i>International
    Journal of Molecular Sciences</i>, vol. 23, no. 11. MDPI, p. 6352, 2022.
  ista: Bilanovičová V, Rýdza N, Koczka L, Hess M, Feraru E, Friml J, Nodzyński T.
    2022. The hydrophilic loop of Arabidopsis PIN1 auxin efflux carrier harbors hallmarks
    of an intrinsically disordered protein. International Journal of Molecular Sciences.
    23(11), 6352.
  mla: Bilanovičová, V., et al. “The Hydrophilic Loop of Arabidopsis PIN1 Auxin Efflux
    Carrier Harbors Hallmarks of an Intrinsically Disordered Protein.” <i>International
    Journal of Molecular Sciences</i>, vol. 23, no. 11, MDPI, 2022, p. 6352, doi:<a
    href="https://doi.org/10.3390/ijms23116352">10.3390/ijms23116352</a>.
  short: V. Bilanovičová, N. Rýdza, L. Koczka, M. Hess, E. Feraru, J. Friml, T. Nodzyński,
    International Journal of Molecular Sciences 23 (2022) 6352.
corr_author: '1'
date_created: 2022-07-05T15:14:34Z
date_published: 2022-06-06T00:00:00Z
date_updated: 2025-04-15T08:12:07Z
day: '06'
ddc:
- '570'
department:
- _id: JiFr
doi: 10.3390/ijms23116352
external_id:
  isi:
  - '000808733300001'
  pmid:
  - '35683031'
file:
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  creator: cchlebak
  date_created: 2022-07-06T07:36:59Z
  date_updated: 2022-07-06T07:36:59Z
  file_id: '11492'
  file_name: 2022_IntJMolSci_Bilanovicova.pdf
  file_size: 2324542
  relation: main_file
  success: 1
file_date_updated: 2022-07-06T07:36:59Z
has_accepted_license: '1'
intvolume: '        23'
isi: 1
issue: '11'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: '6352'
pmid: 1
project:
- _id: 262EF96E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P29988
  name: RNA-directed DNA methylation in plant development
publication: International Journal of Molecular Sciences
publication_identifier:
  issn:
  - 1422-0067
publication_status: published
publisher: MDPI
quality_controlled: '1'
scopus_import: '1'
status: public
title: The hydrophilic loop of Arabidopsis PIN1 auxin efflux carrier harbors hallmarks
  of an intrinsically disordered protein
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2022'
...
---
_id: '11490'
abstract:
- lang: eng
  text: Directly characterising the first generations of stars in distant galaxies
    is a key quest of observational cosmology. We present a case study of ID53 at
    z = 4.77, the UV-brightest (but L⋆) star-forming galaxy at z > 3 in the MUSE eXtremely
    Deep Field with a mass of ≈109 M⊙. In addition to very strong Lyman-α (Lyα) emission,
    we clearly detect the (stellar) continuum and an N V P Cygni feature, interstellar
    absorption, fine-structure emission and nebular C IV emission lines in the 140
    h spectrum. Continuum emission from two spatially resolved components in Hubble
    Space Telescope data are blended in the MUSE data, but we show that the nebular
    C IV emission originates from a subcomponent of the galaxy. The UV spectrum can
    be fit with recent BPASS stellar population models combined with single-burst
    or continuous star formation histories (SFHs), a standard initial mass function,
    and an attenuation law. Models with a young age and low metallicity (log10(age/yr)
    = 6.5–7.6 and [Z/H] = −2.15 to −1.15) are preferred, but the details depend on
    the assumed SFH. The intrinsic Hα luminosity of the best-fit models is an order
    of magnitude higher than the Hα luminosity inferred from Spitzer/IRAC data, which
    either suggests a high escape fraction of ionising photons, a high relative attenuation
    of nebular to stellar dust, or a complex SFH. The metallicity appears lower than
    the metallicity in more massive galaxies at z = 3 − 5, consistent with the scenario
    according to which younger galaxies have lower metallicities. This chemical immaturity
    likely facilitates Lyα escape, explaining why the Lyα equivalent width is anti-correlated
    with stellar metallicity. Finally, we stress that uncertainties in SFHs impose
    a challenge for future inferences of the stellar metallicity of young galaxies.
    This highlights the need for joint (spatially resolved) analyses of stellar spectra
    and photo-ionisation models.
acknowledgement: We thank the referee for thoughtful and constructive comments that
  have improved the quality of this manuscript. Based on observations collected at
  the European Southern Observatory under ESO programme 1101.A-0127. This work made
  use of v2.2.1 of the Binary Population and Spectral Synthesis (BPASS) models as
  described in Eldridge et al. (2017) and Stanway & Eldridge (2018). A.F. acknowledges
  the support from grant PRIN MIUR2017-20173ML3WW_001. T.N. acknowledges support from
  Australian Research Council Laureate Fellowship FL180100060.
article_number: A10
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
- first_name: Anna
  full_name: Feltre, Anna
  last_name: Feltre
- first_name: Michael
  full_name: Maseda, Michael
  last_name: Maseda
- first_name: Themiya
  full_name: Nanayakkara, Themiya
  last_name: Nanayakkara
- first_name: Leindert
  full_name: Boogaard, Leindert
  last_name: Boogaard
- first_name: Roland
  full_name: Bacon, Roland
  last_name: Bacon
- first_name: Anne
  full_name: Verhamme, Anne
  last_name: Verhamme
- first_name: Floriane
  full_name: Leclercq, Floriane
  last_name: Leclercq
- first_name: Haruka
  full_name: Kusakabe, Haruka
  last_name: Kusakabe
- first_name: Tanya
  full_name: Urrutia, Tanya
  last_name: Urrutia
- first_name: Lutz
  full_name: Wisotzki, Lutz
  last_name: Wisotzki
citation:
  ama: 'Matthee JJ, Feltre A, Maseda M, et al. Deciphering stellar metallicities in
    the early universe: Case study of a young galaxy at z = 4.77 in the MUSE eXtremely
    Deep Field. <i>Astronomy &#38; Astrophysics</i>. 2022;660. doi:<a href="https://doi.org/10.1051/0004-6361/202142187">10.1051/0004-6361/202142187</a>'
  apa: 'Matthee, J. J., Feltre, A., Maseda, M., Nanayakkara, T., Boogaard, L., Bacon,
    R., … Wisotzki, L. (2022). Deciphering stellar metallicities in the early universe:
    Case study of a young galaxy at z = 4.77 in the MUSE eXtremely Deep Field. <i>Astronomy
    &#38; Astrophysics</i>. EDP Sciences. <a href="https://doi.org/10.1051/0004-6361/202142187">https://doi.org/10.1051/0004-6361/202142187</a>'
  chicago: 'Matthee, Jorryt J, Anna Feltre, Michael Maseda, Themiya Nanayakkara, Leindert
    Boogaard, Roland Bacon, Anne Verhamme, et al. “Deciphering Stellar Metallicities
    in the Early Universe: Case Study of a Young Galaxy at z = 4.77 in the MUSE EXtremely
    Deep Field.” <i>Astronomy &#38; Astrophysics</i>. EDP Sciences, 2022. <a href="https://doi.org/10.1051/0004-6361/202142187">https://doi.org/10.1051/0004-6361/202142187</a>.'
  ieee: 'J. J. Matthee <i>et al.</i>, “Deciphering stellar metallicities in the early
    universe: Case study of a young galaxy at z = 4.77 in the MUSE eXtremely Deep
    Field,” <i>Astronomy &#38; Astrophysics</i>, vol. 660. EDP Sciences, 2022.'
  ista: 'Matthee JJ, Feltre A, Maseda M, Nanayakkara T, Boogaard L, Bacon R, Verhamme
    A, Leclercq F, Kusakabe H, Urrutia T, Wisotzki L. 2022. Deciphering stellar metallicities
    in the early universe: Case study of a young galaxy at z = 4.77 in the MUSE eXtremely
    Deep Field. Astronomy &#38; Astrophysics. 660, A10.'
  mla: 'Matthee, Jorryt J., et al. “Deciphering Stellar Metallicities in the Early
    Universe: Case Study of a Young Galaxy at z = 4.77 in the MUSE EXtremely Deep
    Field.” <i>Astronomy &#38; Astrophysics</i>, vol. 660, A10, EDP Sciences, 2022,
    doi:<a href="https://doi.org/10.1051/0004-6361/202142187">10.1051/0004-6361/202142187</a>.'
  short: J.J. Matthee, A. Feltre, M. Maseda, T. Nanayakkara, L. Boogaard, R. Bacon,
    A. Verhamme, F. Leclercq, H. Kusakabe, T. Urrutia, L. Wisotzki, Astronomy &#38;
    Astrophysics 660 (2022).
date_created: 2022-07-05T15:25:35Z
date_published: 2022-03-30T00:00:00Z
date_updated: 2024-10-14T11:31:22Z
day: '30'
doi: 10.1051/0004-6361/202142187
extern: '1'
external_id:
  arxiv:
  - '2111.14855'
intvolume: '       660'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: high-redshift / techniques: spectroscopic / galaxies: stellar content
  / galaxies: formation'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2111.14855
month: '03'
oa: 1
oa_version: Published Version
publication: Astronomy & Astrophysics
publication_identifier:
  eissn:
  - 1432-0746
  issn:
  - 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Deciphering stellar metallicities in the early universe: Case study of a young
  galaxy at z = 4.77 in the MUSE eXtremely Deep Field'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 660
year: '2022'
...
---
_id: '11497'
abstract:
- lang: eng
  text: "Context. The hydrogen Lyman α line is often the only measurable feature in
    optical spectra of high-redshift galaxies. Its shape and strength are influenced
    by radiative transfer processes and the properties of the underlying stellar population.
    High equivalent widths of several hundred Å are especially hard to explain by
    models and could point towards unusual stellar populations, for example with low
    metallicities, young stellar ages, and a top-heavy initial mass function. Other
    aspects influencing equivalent widths are the morphology of the galaxy and its
    gas properties.\r\nAims. The aim of this study is to better understand the connection
    between the Lyman α rest-frame equivalent width (EW0) and spectral properties
    as well as ultraviolet (UV) continuum morphology by obtaining reliable EW0 histograms
    for a statistical sample of galaxies and by assessing the fraction of objects
    with large equivalent widths.\r\nMethods. We used integral field spectroscopy
    from the Multi Unit Spectroscopic Explorer (MUSE) combined with broad-band data
    from the Hubble Space Telescope (HST) to measure EW0. We analysed the emission
    lines of 1920 Lyman α emitters (LAEs) detected in the full MUSE-Wide (one hour
    exposure time) and MUSE-Deep (ten hour exposure time) surveys and found UV continuum
    counterparts in archival HST data. We fitted the UV continuum photometric images
    using the Galfit software to gain morphological information on the rest-UV emission
    and fitted the spectra obtained from MUSE to determine the double peak fraction,
    asymmetry, full-width at half maximum, and flux of the Lyman α line.\r\nResults.
    The two surveys show different histograms of Lyman α EW0. In MUSE-Wide, 20% of
    objects have EW0 > 240 Å, while this fraction is only 11% in MUSE-Deep and ≈16%
    for the full sample. This includes objects without HST continuum counterparts
    (one-third of our sample), for which we give lower limits for EW0. The object
    with the highest securely measured EW0 has EW0 = 589 ± 193 Å (the highest lower
    limit being EW0 = 4464 Å). We investigate the connection between EW0 and Lyman
    α spectral or UV continuum morphological properties.\r\nConclusions. The survey
    depth has to be taken into account when studying EW0 distributions. We find that
    in general, high EW0 objects can have a wide range of spectral and UV morphological
    properties, which might reflect that the underlying causes for high EW0 values
    are equally varied."
acknowledgement: We thank the referee for thoughtful and constructive comments that
  have improved the quality of this manuscript. Based on observations collected at
  the European Southern Observatory under ESO programme 1101.A-0127. This work made
  use of v2.2.1 of the Binary Population and Spectral Synthesis (BPASS) models as
  described in Eldridge et al. (2017) and Stanway & Eldridge (2018). A.F. acknowledges
  the support from grant PRIN MIUR2017-20173ML3WW_001. T.N. acknowledges support from
  Australian Research Council Laureate Fellowship FL180100060.
article_number: '183'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: J.
  full_name: Kerutt, J.
  last_name: Kerutt
- first_name: L.
  full_name: Wisotzki, L.
  last_name: Wisotzki
- first_name: A.
  full_name: Verhamme, A.
  last_name: Verhamme
- first_name: K. B.
  full_name: Schmidt, K. B.
  last_name: Schmidt
- first_name: F.
  full_name: Leclercq, F.
  last_name: Leclercq
- first_name: E. C.
  full_name: Herenz, E. C.
  last_name: Herenz
- first_name: T.
  full_name: Urrutia, T.
  last_name: Urrutia
- first_name: T.
  full_name: Garel, T.
  last_name: Garel
- first_name: T.
  full_name: Hashimoto, T.
  last_name: Hashimoto
- first_name: M.
  full_name: Maseda, M.
  last_name: Maseda
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
- first_name: H.
  full_name: Kusakabe, H.
  last_name: Kusakabe
- first_name: J.
  full_name: Schaye, J.
  last_name: Schaye
- first_name: J.
  full_name: Richard, J.
  last_name: Richard
- first_name: B.
  full_name: Guiderdoni, B.
  last_name: Guiderdoni
- first_name: V.
  full_name: Mauerhofer, V.
  last_name: Mauerhofer
- first_name: T.
  full_name: Nanayakkara, T.
  last_name: Nanayakkara
- first_name: E.
  full_name: Vitte, E.
  last_name: Vitte
citation:
  ama: Kerutt J, Wisotzki L, Verhamme A, et al. Equivalent widths of Lyman α emitters
    in MUSE-Wide and MUSE-Deep. <i>Astronomy &#38; Astrophysics</i>. 2022;659. doi:<a
    href="https://doi.org/10.1051/0004-6361/202141900">10.1051/0004-6361/202141900</a>
  apa: Kerutt, J., Wisotzki, L., Verhamme, A., Schmidt, K. B., Leclercq, F., Herenz,
    E. C., … Vitte, E. (2022). Equivalent widths of Lyman α emitters in MUSE-Wide
    and MUSE-Deep. <i>Astronomy &#38; Astrophysics</i>. EDP Sciences. <a href="https://doi.org/10.1051/0004-6361/202141900">https://doi.org/10.1051/0004-6361/202141900</a>
  chicago: Kerutt, J., L. Wisotzki, A. Verhamme, K. B. Schmidt, F. Leclercq, E. C.
    Herenz, T. Urrutia, et al. “Equivalent Widths of Lyman α Emitters in MUSE-Wide
    and MUSE-Deep.” <i>Astronomy &#38; Astrophysics</i>. EDP Sciences, 2022. <a href="https://doi.org/10.1051/0004-6361/202141900">https://doi.org/10.1051/0004-6361/202141900</a>.
  ieee: J. Kerutt <i>et al.</i>, “Equivalent widths of Lyman α emitters in MUSE-Wide
    and MUSE-Deep,” <i>Astronomy &#38; Astrophysics</i>, vol. 659. EDP Sciences, 2022.
  ista: Kerutt J, Wisotzki L, Verhamme A, Schmidt KB, Leclercq F, Herenz EC, Urrutia
    T, Garel T, Hashimoto T, Maseda M, Matthee JJ, Kusakabe H, Schaye J, Richard J,
    Guiderdoni B, Mauerhofer V, Nanayakkara T, Vitte E. 2022. Equivalent widths of
    Lyman α emitters in MUSE-Wide and MUSE-Deep. Astronomy &#38; Astrophysics. 659,
    183.
  mla: Kerutt, J., et al. “Equivalent Widths of Lyman α Emitters in MUSE-Wide and
    MUSE-Deep.” <i>Astronomy &#38; Astrophysics</i>, vol. 659, 183, EDP Sciences,
    2022, doi:<a href="https://doi.org/10.1051/0004-6361/202141900">10.1051/0004-6361/202141900</a>.
  short: J. Kerutt, L. Wisotzki, A. Verhamme, K.B. Schmidt, F. Leclercq, E.C. Herenz,
    T. Urrutia, T. Garel, T. Hashimoto, M. Maseda, J.J. Matthee, H. Kusakabe, J. Schaye,
    J. Richard, B. Guiderdoni, V. Mauerhofer, T. Nanayakkara, E. Vitte, Astronomy
    &#38; Astrophysics 659 (2022).
date_created: 2022-07-06T08:17:27Z
date_published: 2022-03-25T00:00:00Z
date_updated: 2022-07-19T09:47:16Z
day: '25'
doi: 10.1051/0004-6361/202141900
extern: '1'
external_id:
  arxiv:
  - '2202.06642'
intvolume: '       659'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: high-redshift / galaxies: formation / galaxies: evolution / cosmology:
  observations'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2202.06642
month: '03'
oa: 1
oa_version: Published Version
publication: Astronomy & Astrophysics
publication_identifier:
  eissn:
  - 1432-0746
  issn:
  - 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Equivalent widths of Lyman α emitters in MUSE-Wide and MUSE-Deep
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 659
year: '2022'
...
---
_id: '11509'
abstract:
- lang: eng
  text: We present Keck/LRIS follow-up spectroscopy for 13 photometric candidates
    of extremely metal-poor galaxies (EMPGs) selected by a machine-learning technique
    applied to the deep (∼26 AB mag) optical and wide-area (∼500 deg2) Subaru imaging
    data in the EMPRESS survey. Nine out of the 13 candidates are EMPGs with an oxygen
    abundance (O/H) less than ∼10% solar value (O/H)⊙, and four sources are contaminants
    of moderately metal-rich galaxies or no emission-line objects. Notably, two out
    of the nine EMPGs have extremely low stellar masses and oxygen abundances of 5
    × 10⁴x–7 × -10⁵ M⊙ and 2%–3% (O/H)⊙, respectively. With a sample of five EMPGs
    with (Fe/O) measurements, two (three) of which are taken from this study (the
    literature), we confirm that two EMPGs with the lowest (O/H) ratios of ∼2% (O/H)⊙
    show high (Fe/O) ratios of ∼0.1, close to the solar abundance ratio. Comparing
    galaxy chemical enrichment models, we find that the two EMPGs cannot be explained
    by a scenario of metal-poor gas accretion/episodic star formation history due
    to their low (N/O) ratios. We conclude that the two EMPGs can be reproduced by
    the inclusion of bright hypernovae and/or hypothetical pair-instability supernovae
    (SNe) preferentially produced in a metal-poor environment. This conclusion implies
    that primordial galaxies at z ∼ 10 could have a high abundance of Fe that did
    not originate from Type Ia SNe with delays and that Fe may not serve as a cosmic
    clock for primordial galaxies.
acknowledgement: We thank the referee for the valuable comments. We are also grateful
  to Koh Takahashi, Nozomu Tominaga, Chiaki Kobayashi, Yutaka Hirai, and Daichi Kashino
  for having useful discussions. This paper includes data gathered with the 10 m Keck
  Telescope located at W. M. Keck Observatory, Hawaii. We thank the staff of Keck
  Observatory for their help with the observations. The Hyper Suprime-Cam (HSC) collaboration
  includes the astronomical communities of Japan and Taiwan, and Princeton University.
  The HSC instrumentation and software were developed by the National Astronomical
  Observatory of Japan (NAOJ), the Kavli Institute for the Physics and Mathematics
  of the Universe (Kavli IPMU), the University of Tokyo, the High Energy Accelerator
  Research Organization (KEK), the Academia Sinica Institute for Astronomy and Astrophysics
  in Taiwan (ASIAA), and Princeton University. Based on data collected at the Subaru
  Telescope and retrieved from the HSC data archive system, which is operated by the
  Subaru Telescope and Astronomy Data Center at NAOJ. This work was supported by the
  joint research program of the Institute for Cosmic Ray Research (ICRR), University
  of Tokyo. The Cosmic Dawn Center is funded by the Danish National Research Foundation
  under grant No. 140. S.F. acknowledges support from the European Research Council
  (ERC) Consolidator Grant funding scheme (project ConTExt, grant No. 648179). This
  project has received funding from the European Union’s Horizon 2020 research and
  innovation program under the Marie Sklodowska-Curie grant agreement No. 847523 “INTERACTIONS.”
  This work is supported by World Premier International Research Center Initiative
  (WPI Initiative), MEXT, Japan, as well as the KAKENHI Grant-in-Aid for Scientific
  Research (A; 15H02064, 17H01110, 17H01114, 20H00180, and 21H04467) through the Japan
  Society for the Promotion of Science (JSPS). This work has been supported in part
  by JSPS KAKENHI grant Nos. JP17K05382, JP20K04024, and JP21H04499 (K.N.). Yuki Isobe,
  Kimihiko Nakajima, Yuichi Harikane, Takashi Kojima, and Masato Onodera are supported
  by JSPS KAKENHI grant Nos. 21J20785, 20K22373,19J01222, 18J12840, and 17K14257,
  respectively.
article_number: '111'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Yuki
  full_name: Isobe, Yuki
  last_name: Isobe
- first_name: Masami
  full_name: Ouchi, Masami
  last_name: Ouchi
- first_name: Akihiro
  full_name: Suzuki, Akihiro
  last_name: Suzuki
- first_name: Takashi J.
  full_name: Moriya, Takashi J.
  last_name: Moriya
- first_name: Kimihiko
  full_name: Nakajima, Kimihiko
  last_name: Nakajima
- first_name: Ken’ichi
  full_name: Nomoto, Ken’ichi
  last_name: Nomoto
- first_name: Michael
  full_name: Rauch, Michael
  last_name: Rauch
- first_name: Yuichi
  full_name: Harikane, Yuichi
  last_name: Harikane
- first_name: Takashi
  full_name: Kojima, Takashi
  last_name: Kojima
- first_name: Yoshiaki
  full_name: Ono, Yoshiaki
  last_name: Ono
- first_name: Seiji
  full_name: Fujimoto, Seiji
  last_name: Fujimoto
- first_name: Akio K.
  full_name: Inoue, Akio K.
  last_name: Inoue
- first_name: Ji Hoon
  full_name: Kim, Ji Hoon
  last_name: Kim
- first_name: Yutaka
  full_name: Komiyama, Yutaka
  last_name: Komiyama
- first_name: Haruka
  full_name: Kusakabe, Haruka
  last_name: Kusakabe
- first_name: Chien-Hsiu
  full_name: Lee, Chien-Hsiu
  last_name: Lee
- first_name: Michael
  full_name: Maseda, Michael
  last_name: Maseda
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
- first_name: Leo
  full_name: Michel-Dansac, Leo
  last_name: Michel-Dansac
- first_name: Tohru
  full_name: Nagao, Tohru
  last_name: Nagao
- first_name: Themiya
  full_name: Nanayakkara, Themiya
  last_name: Nanayakkara
- first_name: Moka
  full_name: Nishigaki, Moka
  last_name: Nishigaki
- first_name: Masato
  full_name: Onodera, Masato
  last_name: Onodera
- first_name: Yuma
  full_name: Sugahara, Yuma
  last_name: Sugahara
- first_name: Yi
  full_name: Xu, Yi
  last_name: Xu
citation:
  ama: 'Isobe Y, Ouchi M, Suzuki A, et al. EMPRESS. IV. Extremely metal-poor galaxies
    including very low-mass primordial systems with M∗= 10<sup>4</sup>-10<sup>5</sup>⊙
    and 2%–3% (O/H): High (Fe/O) suggestive of metal enrichment by hypernovae/pair-instability
    supernovae. <i>The Astrophysical Journal</i>. 2022;925(2). doi:<a href="https://doi.org/10.3847/1538-4357/ac3509">10.3847/1538-4357/ac3509</a>'
  apa: 'Isobe, Y., Ouchi, M., Suzuki, A., Moriya, T. J., Nakajima, K., Nomoto, K.,
    … Xu, Y. (2022). EMPRESS. IV. Extremely metal-poor galaxies including very low-mass
    primordial systems with M∗= 10<sup>4</sup>-10<sup>5</sup>⊙ and 2%–3% (O/H): High
    (Fe/O) suggestive of metal enrichment by hypernovae/pair-instability supernovae.
    <i>The Astrophysical Journal</i>. IOP Publishing. <a href="https://doi.org/10.3847/1538-4357/ac3509">https://doi.org/10.3847/1538-4357/ac3509</a>'
  chicago: 'Isobe, Yuki, Masami Ouchi, Akihiro Suzuki, Takashi J. Moriya, Kimihiko
    Nakajima, Ken’ichi Nomoto, Michael Rauch, et al. “EMPRESS. IV. Extremely Metal-Poor
    Galaxies Including Very Low-Mass Primordial Systems with M∗= 10<sup>4</sup>-10<sup>5</sup>⊙
    and 2%–3% (O/H): High (Fe/O) Suggestive of Metal Enrichment by Hypernovae/Pair-Instability
    Supernovae.” <i>The Astrophysical Journal</i>. IOP Publishing, 2022. <a href="https://doi.org/10.3847/1538-4357/ac3509">https://doi.org/10.3847/1538-4357/ac3509</a>.'
  ieee: 'Y. Isobe <i>et al.</i>, “EMPRESS. IV. Extremely metal-poor galaxies including
    very low-mass primordial systems with M∗= 10<sup>4</sup>-10<sup>5</sup>⊙ and 2%–3%
    (O/H): High (Fe/O) suggestive of metal enrichment by hypernovae/pair-instability
    supernovae,” <i>The Astrophysical Journal</i>, vol. 925, no. 2. IOP Publishing,
    2022.'
  ista: 'Isobe Y, Ouchi M, Suzuki A, Moriya TJ, Nakajima K, Nomoto K, Rauch M, Harikane
    Y, Kojima T, Ono Y, Fujimoto S, Inoue AK, Kim JH, Komiyama Y, Kusakabe H, Lee
    C-H, Maseda M, Matthee JJ, Michel-Dansac L, Nagao T, Nanayakkara T, Nishigaki
    M, Onodera M, Sugahara Y, Xu Y. 2022. EMPRESS. IV. Extremely metal-poor galaxies
    including very low-mass primordial systems with M∗= 10<sup>4</sup>-10<sup>5</sup>⊙
    and 2%–3% (O/H): High (Fe/O) suggestive of metal enrichment by hypernovae/pair-instability
    supernovae. The Astrophysical Journal. 925(2), 111.'
  mla: 'Isobe, Yuki, et al. “EMPRESS. IV. Extremely Metal-Poor Galaxies Including
    Very Low-Mass Primordial Systems with M∗= 10<sup>4</sup>-10<sup>5</sup>⊙ and 2%–3%
    (O/H): High (Fe/O) Suggestive of Metal Enrichment by Hypernovae/Pair-Instability
    Supernovae.” <i>The Astrophysical Journal</i>, vol. 925, no. 2, 111, IOP Publishing,
    2022, doi:<a href="https://doi.org/10.3847/1538-4357/ac3509">10.3847/1538-4357/ac3509</a>.'
  short: Y. Isobe, M. Ouchi, A. Suzuki, T.J. Moriya, K. Nakajima, K. Nomoto, M. Rauch,
    Y. Harikane, T. Kojima, Y. Ono, S. Fujimoto, A.K. Inoue, J.H. Kim, Y. Komiyama,
    H. Kusakabe, C.-H. Lee, M. Maseda, J.J. Matthee, L. Michel-Dansac, T. Nagao, T.
    Nanayakkara, M. Nishigaki, M. Onodera, Y. Sugahara, Y. Xu, The Astrophysical Journal
    925 (2022).
date_created: 2022-07-06T12:01:48Z
date_published: 2022-01-31T00:00:00Z
date_updated: 2022-07-21T05:51:25Z
day: '31'
doi: 10.3847/1538-4357/ac3509
extern: '1'
external_id:
  arxiv:
  - '2108.03850'
intvolume: '       925'
issue: '2'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2108.03850
month: '01'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
  eissn:
  - 1538-4357
  issn:
  - 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'EMPRESS. IV. Extremely metal-poor galaxies including very low-mass primordial
  systems with M∗= 10⁴-10⁵⊙ and 2%–3% (O/H): High (Fe/O) suggestive of metal enrichment
  by hypernovae/pair-instability supernovae'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 925
year: '2022'
...
---
_id: '11510'
abstract:
- lang: eng
  text: Galaxy evolution is driven by a variety of physical processes that are predicted
    to proceed at different rates for different dark matter haloes and environments
    across cosmic times. A record of this evolution is preserved in galaxy stellar
    populations, which we can access using absorption-line spectroscopy. Here we explore
    the large LEGA-C survey (DR3) to investigate the role of the environment and stellar
    mass on stellar populations at z ∼ 0.6–1 in the COSMOS field. Leveraging the statistical
    power and depth of LEGA-C, we reveal significant gradients in Dn4000 and Hδ equivalent
    widths (EWs) distributions over the stellar mass versus environment 2D spaces
    for the massive galaxy population (M > 1010 M⊙) at z ∼ 0.6–1.0. Dn4000 and Hδ
    EWs primarily depend on stellar mass, but they also depend on environment at fixed
    stellar mass. By splitting the sample into centrals and satellites, and in terms
    of star-forming galaxies and quiescent galaxies, we reveal that the significant
    environmental trends of Dn4000 and Hδ EW, when controlling for stellar mass, are
    driven by quiescent galaxies. Regardless of being centrals or satellites, star-forming
    galaxies reveal Dn4000 and Hδ EWs, which depend strongly on their stellar mass
    and are completely independent of the environment at 0.6 < z < 1.0. The environmental
    trends seen for satellite galaxies are fully driven by the trends that hold only
    for quiescent galaxies, combined with the strong environmental dependency of the
    quiescent fraction at fixed stellar mass. Our results are consistent with recent
    predictions from simulations that point toward massive galaxies forming first
    in overdensities or the most compact dark matter haloes.
acknowledgement: We thank the reviewer for several valuable comments that improved
  the clarity of the manuscript. P.F.W. acknowledges the support of the fellowship
  by the East Asian Core Observatories Association. This work is based on observations
  made with ESO VLT Telescopes at the La Silla Paranal Observatory under programmes
  ID 194-A.2005 and 1100.A-0949 (The LEGA-C Public Spectroscopy Survey). This project
  has received funding from the European Research Council (ERC) under the European
  Union—Horizon 2020 research and innovation program (grant agreement No. 683184).
article_number: '117'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: David
  full_name: Sobral, David
  last_name: Sobral
- first_name: Arjen
  full_name: van der Wel, Arjen
  last_name: van der Wel
- first_name: Rachel
  full_name: Bezanson, Rachel
  last_name: Bezanson
- first_name: Eric
  full_name: Bell, Eric
  last_name: Bell
- first_name: Adam
  full_name: Muzzin, Adam
  last_name: Muzzin
- first_name: Francesco
  full_name: D’Eugenio, Francesco
  last_name: D’Eugenio
- first_name: Behnam
  full_name: Darvish, Behnam
  last_name: Darvish
- first_name: Anna
  full_name: Gallazzi, Anna
  last_name: Gallazzi
- first_name: Po-Feng
  full_name: Wu, Po-Feng
  last_name: Wu
- first_name: Michael
  full_name: Maseda, Michael
  last_name: Maseda
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
- first_name: Ana
  full_name: Paulino-Afonso, Ana
  last_name: Paulino-Afonso
- first_name: Caroline
  full_name: Straatman, Caroline
  last_name: Straatman
- first_name: Pieter G.
  full_name: van Dokkum, Pieter G.
  last_name: van Dokkum
citation:
  ama: 'Sobral D, van der Wel A, Bezanson R, et al. The LEGA-C of nature and nurture
    in stellar populations at z ∼ 0.6–1.0: Dn4000 and Hδ reveal different assembly
    histories for quiescent galaxies in different environments. <i>The Astrophysical
    Journal</i>. 2022;926(2). doi:<a href="https://doi.org/10.3847/1538-4357/ac4419">10.3847/1538-4357/ac4419</a>'
  apa: 'Sobral, D., van der Wel, A., Bezanson, R., Bell, E., Muzzin, A., D’Eugenio,
    F., … van Dokkum, P. G. (2022). The LEGA-C of nature and nurture in stellar populations
    at z ∼ 0.6–1.0: Dn4000 and Hδ reveal different assembly histories for quiescent
    galaxies in different environments. <i>The Astrophysical Journal</i>. IOP Publishing.
    <a href="https://doi.org/10.3847/1538-4357/ac4419">https://doi.org/10.3847/1538-4357/ac4419</a>'
  chicago: 'Sobral, David, Arjen van der Wel, Rachel Bezanson, Eric Bell, Adam Muzzin,
    Francesco D’Eugenio, Behnam Darvish, et al. “The LEGA-C of Nature and Nurture
    in Stellar Populations at z ∼ 0.6–1.0: Dn4000 and Hδ Reveal Different Assembly
    Histories for Quiescent Galaxies in Different Environments.” <i>The Astrophysical
    Journal</i>. IOP Publishing, 2022. <a href="https://doi.org/10.3847/1538-4357/ac4419">https://doi.org/10.3847/1538-4357/ac4419</a>.'
  ieee: 'D. Sobral <i>et al.</i>, “The LEGA-C of nature and nurture in stellar populations
    at z ∼ 0.6–1.0: Dn4000 and Hδ reveal different assembly histories for quiescent
    galaxies in different environments,” <i>The Astrophysical Journal</i>, vol. 926,
    no. 2. IOP Publishing, 2022.'
  ista: 'Sobral D, van der Wel A, Bezanson R, Bell E, Muzzin A, D’Eugenio F, Darvish
    B, Gallazzi A, Wu P-F, Maseda M, Matthee JJ, Paulino-Afonso A, Straatman C, van
    Dokkum PG. 2022. The LEGA-C of nature and nurture in stellar populations at z
    ∼ 0.6–1.0: Dn4000 and Hδ reveal different assembly histories for quiescent galaxies
    in different environments. The Astrophysical Journal. 926(2), 117.'
  mla: 'Sobral, David, et al. “The LEGA-C of Nature and Nurture in Stellar Populations
    at z ∼ 0.6–1.0: Dn4000 and Hδ Reveal Different Assembly Histories for Quiescent
    Galaxies in Different Environments.” <i>The Astrophysical Journal</i>, vol. 926,
    no. 2, 117, IOP Publishing, 2022, doi:<a href="https://doi.org/10.3847/1538-4357/ac4419">10.3847/1538-4357/ac4419</a>.'
  short: D. Sobral, A. van der Wel, R. Bezanson, E. Bell, A. Muzzin, F. D’Eugenio,
    B. Darvish, A. Gallazzi, P.-F. Wu, M. Maseda, J.J. Matthee, A. Paulino-Afonso,
    C. Straatman, P.G. van Dokkum, The Astrophysical Journal 926 (2022).
date_created: 2022-07-06T12:38:42Z
date_published: 2022-02-17T00:00:00Z
date_updated: 2022-07-19T09:37:42Z
day: '17'
doi: 10.3847/1538-4357/ac4419
extern: '1'
external_id:
  arxiv:
  - '2112.08372'
intvolume: '       926'
issue: '2'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2112.08372
month: '02'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
  eissn:
  - 1538-4357
  issn:
  - 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The LEGA-C of nature and nurture in stellar populations at z ∼ 0.6–1.0: Dn4000
  and Hδ reveal different assembly histories for quiescent galaxies in different environments'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 926
year: '2022'
...
---
_id: '11511'
abstract:
- lang: eng
  text: The ratio of α-elements to iron in galaxies holds valuable information about
    the star formation history (SFH) since their enrichment occurs on different timescales.
    The fossil record of stars in galaxies has mostly been excavated for passive galaxies,
    since the light of star-forming galaxies is dominated by young stars, which have
    much weaker atmospheric absorption features. Here we use the largest reference
    cosmological simulation of the EAGLE project to investigate the origin of variations
    in stellar α-enhancement among star-forming galaxies at z = 0, and their impact
    on integrated spectra. The definition of α-enhancement in a composite stellar
    population is ambiguous. We elucidate two definitions—termed “mean” and “galactic”
    α-enhancement—in more detail. While a star-forming galaxy has a high “mean” α-enhancement
    when its stars formed rapidly, a galaxy with a large “galactic” α-enhancement
    generally had a delayed SFH. We find that absorption-line strengths of Mg and
    Fe correlate with variations in α-enhancement. These correlations are strongest
    for the “galactic” α-enhancement. However, we show that these are mostly caused
    by other effects that are cross-correlated with α-enhancement, such as variations
    in the light-weighted age. This severely complicates the retrieval of α-enhancements
    in star-forming galaxies. The ambiguity is not severe for passive galaxies, and
    we confirm that spectral variations in these galaxies are caused by measurable
    variations in α-enhancements. We suggest that this more complex coupling between
    α-enhancement and SFHs can guide the interpretation of new observations of star-forming
    galaxies.
acknowledgement: "We thank our anonymous referee for the constructive feedback. We
  extend our gratitude to Maarten Baes, Simon Lilly, Rafael Ottersberg, Gabriele Pezzulli,
  Alvio Renzini, and Andrea Weibel for insightful discussions. A.G. gratefully acknowledges
  financial support from the Fund for Scientific Research Flanders (FWO-Vlaanderen,
  project G.0G04.16N). This work used the DiRAC Data Centric system at Durham University,
  operated by the ICC on behalf of the STFC DiRAC HPC Facility (www.dirac.ac.uk).
  This equipment was funded by BIS National E-infrastructure capital grant ST/K00042X/1,
  STFC capital grant ST/H008519/1, and STFC DiRAC Operations grant ST/K003267/1 and
  Durham University. DiRAC is part of the National E-Infrastructure.\r\n\r\nWe have
  benefited from the data analysis tool Topcat (Taylor 2013) and the programming language
  Python, including the numpy (van der Walt et al. 2011), matplotlib (Hunter 2007),
  and scipy (Virtanen et al. 2020) packages."
article_number: '73'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Andrea
  full_name: Gebek, Andrea
  last_name: Gebek
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
citation:
  ama: Gebek A, Matthee JJ. On the variation in stellar α-enhancements of star-forming
    galaxies in the EAGLE simulation. <i>The Astrophysical Journal</i>. 2022;924(2).
    doi:<a href="https://doi.org/10.3847/1538-4357/ac350b">10.3847/1538-4357/ac350b</a>
  apa: Gebek, A., &#38; Matthee, J. J. (2022). On the variation in stellar α-enhancements
    of star-forming galaxies in the EAGLE simulation. <i>The Astrophysical Journal</i>.
    IOP Publishing. <a href="https://doi.org/10.3847/1538-4357/ac350b">https://doi.org/10.3847/1538-4357/ac350b</a>
  chicago: Gebek, Andrea, and Jorryt J Matthee. “On the Variation in Stellar α-Enhancements
    of Star-Forming Galaxies in the EAGLE Simulation.” <i>The Astrophysical Journal</i>.
    IOP Publishing, 2022. <a href="https://doi.org/10.3847/1538-4357/ac350b">https://doi.org/10.3847/1538-4357/ac350b</a>.
  ieee: A. Gebek and J. J. Matthee, “On the variation in stellar α-enhancements of
    star-forming galaxies in the EAGLE simulation,” <i>The Astrophysical Journal</i>,
    vol. 924, no. 2. IOP Publishing, 2022.
  ista: Gebek A, Matthee JJ. 2022. On the variation in stellar α-enhancements of star-forming
    galaxies in the EAGLE simulation. The Astrophysical Journal. 924(2), 73.
  mla: Gebek, Andrea, and Jorryt J. Matthee. “On the Variation in Stellar α-Enhancements
    of Star-Forming Galaxies in the EAGLE Simulation.” <i>The Astrophysical Journal</i>,
    vol. 924, no. 2, 73, IOP Publishing, 2022, doi:<a href="https://doi.org/10.3847/1538-4357/ac350b">10.3847/1538-4357/ac350b</a>.
  short: A. Gebek, J.J. Matthee, The Astrophysical Journal 924 (2022).
date_created: 2022-07-06T12:48:32Z
date_published: 2022-01-13T00:00:00Z
date_updated: 2024-10-14T11:31:47Z
day: '13'
doi: 10.3847/1538-4357/ac350b
extern: '1'
external_id:
  arxiv:
  - '2102.04561'
intvolume: '       924'
issue: '2'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2102.04561
month: '01'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
  eissn:
  - 1538-4357
  issn:
  - 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the variation in stellar α-enhancements of star-forming galaxies in the
  EAGLE simulation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 924
year: '2022'
...
