---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21115'
abstract:
- lang: eng
  text: Quantifying cell morphology is central to understanding cellular regulation,
    fate, and heterogeneity, yet conventional image-based analyses often struggle
    with diverse or irregular shapes. We present a computational framework that uses
    topological data analysis to characterise and compare single-cell morphologies
    from fluorescence microscopy. Each cell is represented by its contour together
    with the position of its nucleus, from which we construct a filtration based on
    a radial distance function and derive a persistence diagram encoding the shape’s
    topological evolution. The similarity between two cells is quantified using the
    2-Wasserstein distance between their diagrams, yielding a shape distance we call
    the PH distance. We apply this method to two representative experimental systems—primary
    human mesenchymal stem cells (hMSCs) and HeLa cells—and show that PH distances
    enable the detection of outliers in those systems, the identification of sub-populations,
    and the quantification of shape heterogeneity. We benchmark PH against three established
    contour-based distances (aspect ratio, Fourier descriptors, and elastic shape
    analysis) and show that PH offers better separation between cell types and greater
    robustness when clustering heterogeneous populations. Together, these results
    demonstrate that persistent-homology-based signatures provide a principled and
    sensitive approach for analysing cell morphology in settings where traditional
    geometric or image-based descriptors are insufficient.
acknowledgement: We thank Stephan Huckemann, Katharine Turner, Benjamin Eltzner, Stephan
  Tillmann, Fariza Rashid, Vanessa Robins, and Lamiae Azizi for many useful discussions
  at various stages of this project. FR and PY gratefully acknowledge Matthias Weiss
  (Experimental Physics I, University of Bayreuth, Germany) for granting access to
  cell culture and laboratories, as well as funding consumables and the fruitful discussion
  that contributed to this work. For open access purposes, the author has applied
  a CC BY public copyright license to any author-accepted manuscript version arising
  from this submission.
article_number: e1013890
article_processing_charge: Yes
article_type: original
author:
- first_name: Yossi
  full_name: Bleile, Yossi
  id: 920a7385-7995-11ef-9bfd-8c434cd8f3c2
  last_name: Bleile
  orcid: 0000-0002-4861-9174
- first_name: Pooja
  full_name: Yadav, Pooja
  last_name: Yadav
- first_name: Patrice
  full_name: Koehl, Patrice
  last_name: Koehl
- first_name: Florian
  full_name: Rehfeldt, Florian
  last_name: Rehfeldt
citation:
  ama: 'Bleile Y, Yadav P, Koehl P, Rehfeldt F. Persistence diagrams as morphological
    signatures of cells: A method to measure and compare cells within a population.
    <i>PLoS Computational Biology</i>. 2026;22. doi:<a href="https://doi.org/10.1371/journal.pcbi.1013890">10.1371/journal.pcbi.1013890</a>'
  apa: 'Bleile, Y., Yadav, P., Koehl, P., &#38; Rehfeldt, F. (2026). Persistence diagrams
    as morphological signatures of cells: A method to measure and compare cells within
    a population. <i>PLoS Computational Biology</i>. Public Library of Science. <a
    href="https://doi.org/10.1371/journal.pcbi.1013890">https://doi.org/10.1371/journal.pcbi.1013890</a>'
  chicago: 'Bleile, Yossi, Pooja Yadav, Patrice Koehl, and Florian Rehfeldt. “Persistence
    Diagrams as Morphological Signatures of Cells: A Method to Measure and Compare
    Cells within a Population.” <i>PLoS Computational Biology</i>. Public Library
    of Science, 2026. <a href="https://doi.org/10.1371/journal.pcbi.1013890">https://doi.org/10.1371/journal.pcbi.1013890</a>.'
  ieee: 'Y. Bleile, P. Yadav, P. Koehl, and F. Rehfeldt, “Persistence diagrams as
    morphological signatures of cells: A method to measure and compare cells within
    a population,” <i>PLoS Computational Biology</i>, vol. 22. Public Library of Science,
    2026.'
  ista: 'Bleile Y, Yadav P, Koehl P, Rehfeldt F. 2026. Persistence diagrams as morphological
    signatures of cells: A method to measure and compare cells within a population.
    PLoS Computational Biology. 22, e1013890.'
  mla: 'Bleile, Yossi, et al. “Persistence Diagrams as Morphological Signatures of
    Cells: A Method to Measure and Compare Cells within a Population.” <i>PLoS Computational
    Biology</i>, vol. 22, e1013890, Public Library of Science, 2026, doi:<a href="https://doi.org/10.1371/journal.pcbi.1013890">10.1371/journal.pcbi.1013890</a>.'
  short: Y. Bleile, P. Yadav, P. Koehl, F. Rehfeldt, PLoS Computational Biology 22
    (2026).
corr_author: '1'
date_created: 2026-01-30T10:36:32Z
date_published: 2026-01-28T00:00:00Z
date_updated: 2026-02-12T14:23:54Z
day: '28'
ddc:
- '000'
department:
- _id: HeEd
doi: 10.1371/journal.pcbi.1013890
external_id:
  pmid:
  - '41604421'
file:
- access_level: open_access
  checksum: 3899d929ee9be0453c95524e49992d72
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  creator: dernst
  date_created: 2026-02-10T07:13:06Z
  date_updated: 2026-02-10T07:13:06Z
  file_id: '21204'
  file_name: 2026_PloSCompBio_Bleile.pdf
  file_size: 8908746
  relation: main_file
  success: 1
file_date_updated: 2026-02-10T07:13:06Z
has_accepted_license: '1'
intvolume: '        22'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
publication: PLoS Computational Biology
publication_identifier:
  issn:
  - 1553-7358
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
related_material:
  link:
  - relation: software
    url: https://github.com/yossibokorbleile/correa
scopus_import: '1'
status: public
title: 'Persistence diagrams as morphological signatures of cells: A method to measure
  and compare cells within a population'
tmp:
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  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 22
year: '2026'
...
---
_id: '21116'
abstract:
- lang: eng
  text: Sex-chromosome systems are highly variable across animals, but how they transition
    from one to another is not well understood. Diptera have undergone multiple sex-chromosome
    turnovers and expansions while maintaining their general chromosomal content,
    which makes them an ideal clade to study such transitions. We analyzed more than
    100 dipteran whole-genome assemblies and identified 4 new lineages that underwent
    sex-chromosome turnover (in addition to the 5 previously reported). We find that
    the majority of turnovers happened in the group Schizophora, which tend to have
    fewer genes on Muller element F (the chromosome homologous to the ancestral insect
    X chromosome) than lower dipterans, a factor previously hypothesized to facilitate
    turnover. Most derived X chromosomes have higher GC content than autosomes, consistent
    with a high prevalence of male achiasmy in Diptera. In addition, an excess of
    gene movement out of the X is detected for most of these new X chromosomes, and
    many of these moved genes have high testis expression in Drosophila, suggesting
    that out-of-X gene movement contributes to the long-term demasculinization of
    X chromosomes.
article_processing_charge: No
author:
- first_name: Lorena Alexandra
  full_name: Layana Franco, Lorena Alexandra
  id: 02814589-eb8f-11eb-b029-a70074f3f18f
  last_name: Layana Franco
  orcid: 0000-0002-1253-6297
- first_name: Melissa A
  full_name: Toups, Melissa A
  id: 4E099E4E-F248-11E8-B48F-1D18A9856A87
  last_name: Toups
  orcid: 0000-0002-9752-7380
- first_name: Beatriz
  full_name: Vicoso, Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
citation:
  ama: Layana Franco LA, Toups MA, Vicoso B. Research Data for “Causes and consequences
    of sex-chromosome turnovers in Diptera.” 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-21116">10.15479/AT-ISTA-21116</a>
  apa: Layana Franco, L. A., Toups, M. A., &#38; Vicoso, B. (2026). Research Data
    for “Causes and consequences of sex-chromosome turnovers in Diptera.” Institute
    of Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-21116">https://doi.org/10.15479/AT-ISTA-21116</a>
  chicago: Layana Franco, Lorena Alexandra, Melissa A Toups, and Beatriz Vicoso. “Research
    Data for ‘Causes and Consequences of Sex-Chromosome Turnovers in Diptera.’” Institute
    of Science and Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-21116">https://doi.org/10.15479/AT-ISTA-21116</a>.
  ieee: L. A. Layana Franco, M. A. Toups, and B. Vicoso, “Research Data for ‘Causes
    and consequences of sex-chromosome turnovers in Diptera.’” Institute of Science
    and Technology Austria, 2026.
  ista: Layana Franco LA, Toups MA, Vicoso B. 2026. Research Data for ‘Causes and
    consequences of sex-chromosome turnovers in Diptera’, Institute of Science and
    Technology Austria, <a href="https://doi.org/10.15479/AT-ISTA-21116">10.15479/AT-ISTA-21116</a>.
  mla: Layana Franco, Lorena Alexandra, et al. <i>Research Data for “Causes and Consequences
    of Sex-Chromosome Turnovers in Diptera.”</i> Institute of Science and Technology
    Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-21116">10.15479/AT-ISTA-21116</a>.
  short: L.A. Layana Franco, M.A. Toups, B. Vicoso, (2026).
corr_author: '1'
date_created: 2026-01-30T11:04:14Z
date_published: 2026-01-02T00:00:00Z
date_updated: 2026-02-12T12:58:00Z
day: '2'
department:
- _id: BeVi
doi: 10.15479/AT-ISTA-21116
file:
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  checksum: 0b79be6229f2ad9ac117ef00fc4f5c0e
  content_type: text/plain
  creator: llayanaf
  date_created: 2026-01-30T11:00:24Z
  date_updated: 2026-01-30T11:00:24Z
  file_id: '21117'
  file_name: README.txt
  file_size: 1201
  relation: main_file
  success: 1
- access_level: open_access
  checksum: a3cda72e4177fa1e5d3f0f6a88f8a79b
  content_type: application/zip
  creator: llayanaf
  date_created: 2026-01-30T11:00:36Z
  date_updated: 2026-01-30T11:00:36Z
  file_id: '21118'
  file_name: Supplementary_Tables.zip
  file_size: 572403
  relation: main_file
  success: 1
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  content_type: application/zip
  creator: llayanaf
  date_created: 2026-01-30T11:00:48Z
  date_updated: 2026-01-30T11:00:48Z
  file_id: '21119'
  file_name: Supplementary_Datasets.zip
  file_size: 19054553
  relation: main_file
  success: 1
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  checksum: 254e050f648e9783ba8fe11adb3b49db
  content_type: application/zip
  creator: llayanaf
  date_created: 2026-01-30T11:00:56Z
  date_updated: 2026-01-30T11:00:56Z
  file_id: '21120'
  file_name: Perl_scripts.zip
  file_size: 4575
  relation: main_file
  success: 1
file_date_updated: 2026-01-30T11:00:56Z
has_accepted_license: '1'
keyword:
- Schizophora
- sex chromosomes
- sex-chromosome turnover
- Diptera
- genomic features
- out-of-X movement.
month: '01'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
status: public
title: Research Data for "Causes and consequences of sex-chromosome turnovers in Diptera"
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: research_data
user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21132'
abstract:
- lang: eng
  text: We unify the variational hypocoercivity framework established by D. Albritton,
    S. Armstrong, J.-C. Mourrat, and M. Novack [2], with the notion of second-order
    lifts of reversible diffusion processes, recently introduced by A. Eberle and
    the second author [30]. We give an abstract, yet fully constructive, presentation
    of the theory, so that it can be applied to a large class of linear kinetic equations.
    As this hypocoercivity technique does not twist the reference norm, we can recover
    accurate and sharp convergence rates in various models. Among those, adaptive
    Langevin dynamics (ALD) is discussed in full detail and we show that for near-quadratic
    potentials, with suitable choices of parameters, it is a near-optimal second-order
    lift of the overdamped Langevin dynamics. As a further consequence, we observe
    that the Generalised Langevin Equation (GLE) is also a second-order lift, as the
    standard (kinetic) Langevin dynamics are, of the overdamped Langevin dynamics.
    Then, convergence of (GLE) cannot exceed ballistic speed, i.e. the square root
    of the rate of the overdamped regime. We illustrate this phenomenon with explicit
    computations in a benchmark Gaussian case.
acknowledgement: "We would like to thank Andreas Eberle and Gabriel Stoltz for many
  helpful discussions. GB\r\nhas received funding from the European Union Horizon
  2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement
  No 101034413. FL wurde gefördert durch die Deutsche Forschungsgemeinschaft (DFG)
  im Rahmen der Exzellenzstrategie des Bundes und der Länder – GZ2047/1, Projekt-ID
  390685813. LW is supported by the National Science Foundation via grant DMS-2407166.
  He is also indebted to the Mathematical Sciences department at Carnegie Mellon University
  for partly supporting his visit to Europe in July 2024. Part of this work was completed
  when GB and LW were visiting the Institute for Applied Mathematics in Bonn. GB and
  LW would like to thank IAM for their hospitality."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Giovanni
  full_name: Brigati, Giovanni
  id: 63ff57e8-1fbb-11ee-88f2-f558ffc59cf1
  last_name: Brigati
- first_name: Francis
  full_name: Lörler, Francis
  last_name: Lörler
- first_name: Lihan
  full_name: Wang, Lihan
  last_name: Wang
citation:
  ama: Brigati G, Lörler F, Wang L. Hypocoercivity meets lifts. <i>Kinetic and Related
    Models</i>. 2026;20:34-55. doi:<a href="https://doi.org/10.3934/krm.2025020">10.3934/krm.2025020</a>
  apa: Brigati, G., Lörler, F., &#38; Wang, L. (2026). Hypocoercivity meets lifts.
    <i>Kinetic and Related Models</i>. American Institute of Mathematical Sciences.
    <a href="https://doi.org/10.3934/krm.2025020">https://doi.org/10.3934/krm.2025020</a>
  chicago: Brigati, Giovanni, Francis Lörler, and Lihan Wang. “Hypocoercivity Meets
    Lifts.” <i>Kinetic and Related Models</i>. American Institute of Mathematical
    Sciences, 2026. <a href="https://doi.org/10.3934/krm.2025020">https://doi.org/10.3934/krm.2025020</a>.
  ieee: G. Brigati, F. Lörler, and L. Wang, “Hypocoercivity meets lifts,” <i>Kinetic
    and Related Models</i>, vol. 20. American Institute of Mathematical Sciences,
    pp. 34–55, 2026.
  ista: Brigati G, Lörler F, Wang L. 2026. Hypocoercivity meets lifts. Kinetic and
    Related Models. 20, 34–55.
  mla: Brigati, Giovanni, et al. “Hypocoercivity Meets Lifts.” <i>Kinetic and Related
    Models</i>, vol. 20, American Institute of Mathematical Sciences, 2026, pp. 34–55,
    doi:<a href="https://doi.org/10.3934/krm.2025020">10.3934/krm.2025020</a>.
  short: G. Brigati, F. Lörler, L. Wang, Kinetic and Related Models 20 (2026) 34–55.
date_created: 2026-02-01T23:01:43Z
date_published: 2026-02-01T00:00:00Z
date_updated: 2026-02-16T10:02:47Z
day: '01'
department:
- _id: JaMa
doi: 10.3934/krm.2025020
ec_funded: 1
external_id:
  arxiv:
  - '2412.10890'
intvolume: '        20'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2412.10890
month: '02'
oa: 1
oa_version: Preprint
page: 34-55
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
publication: Kinetic and Related Models
publication_identifier:
  eissn:
  - 1937-5077
  issn:
  - 1937-5093
publication_status: epub_ahead
publisher: American Institute of Mathematical Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Hypocoercivity meets lifts
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '2026'
...
---
OA_place: publisher
OA_type: gold
_id: '21133'
abstract:
- lang: eng
  text: "Data structures based on trees and tree traversals are ubiquitous in computer
    systems. Many low-level programs, including some implementations of critical systems
    like page tables and the web browser DOM, rely on generic tree-traversal functions
    that traverse tree nodes in a pre-determined order, applying a client-provided
    operation to each visited node. Developing a general approach to specifying and
    verifying such traversals is tricky since the client-provided per-node operation
    can be stateful and may potentially depend on or modify the structure of the tree
    being traversed.\r\nIn this paper, we present a recipe for (semi-)automated verification
    of such generic, stateful tree traversals. Our recipe is (a) general: it applies
    to a range of tree traversals, in particular, pre-, post- and in-order depth-first
    traversals; (b) modular: parts of a traversal’s proof can be reused in verifying
    other similar traversals; (c) expressive: using the specification of a tree traversal,
    we can verify clients that use the traversal in a variety of different ways; and
    (d) automatable: many proof obligations can be discharged automatically.\r\nAt
    the heart of our recipe is a novel use of tree zippers to represent a logical
    abstraction of the tree traversal state, and zipper transitions as an abstraction
    of traversal steps. We realize our recipe in the RefinedC framework in Rocq, which
    allows us to verify a number of different tree traversals and their clients written
    in C."
acknowledgement: We thank the anonymous reviewers for their insightful suggestions.
  This research is supported in part by generous awards from Android Security’s ASPIRE
  program and from Google Research. The third author is supported, in part, by ERC
  grant COCONUT (grant no. 101171349), funded by the European Union. Views and opinions
  expressed are however those of the author(s) only and do not necessarily reflect
  those of the European Union or the European Research Council Executive Agency. Neither
  the European Union nor the granting authority can be held responsible for them.
article_processing_charge: No
author:
- first_name: Laila
  full_name: Elbeheiry, Laila
  last_name: Elbeheiry
- first_name: Michael Joachim
  full_name: Sammler, Michael Joachim
  id: 510d3901-2a03-11ee-914d-d9ae9011f0a7
  last_name: Sammler
- first_name: Robbert
  full_name: Krebbers, Robbert
  last_name: Krebbers
- first_name: Derek
  full_name: Dreyer, Derek
  last_name: Dreyer
- first_name: Deepak
  full_name: Garg, Deepak
  last_name: Garg
citation:
  ama: 'Elbeheiry L, Sammler MJ, Krebbers R, Dreyer D, Garg D. A recipe for modular
    verification of generic tree traversals. In: <i>Proceedings of the 15th ACM SIGPLAN
    International Conference on Certified Programs and Proofs</i>. Association for
    Computing Machinery; 2026:339-352. doi:<a href="https://doi.org/10.1145/3779031.3779110">10.1145/3779031.3779110</a>'
  apa: 'Elbeheiry, L., Sammler, M. J., Krebbers, R., Dreyer, D., &#38; Garg, D. (2026).
    A recipe for modular verification of generic tree traversals. In <i>Proceedings
    of the 15th ACM SIGPLAN International Conference on Certified Programs and Proofs</i>
    (pp. 339–352). Rennes, France: Association for Computing Machinery. <a href="https://doi.org/10.1145/3779031.3779110">https://doi.org/10.1145/3779031.3779110</a>'
  chicago: Elbeheiry, Laila, Michael Joachim Sammler, Robbert Krebbers, Derek Dreyer,
    and Deepak Garg. “A Recipe for Modular Verification of Generic Tree Traversals.”
    In <i>Proceedings of the 15th ACM SIGPLAN International Conference on Certified
    Programs and Proofs</i>, 339–52. Association for Computing Machinery, 2026. <a
    href="https://doi.org/10.1145/3779031.3779110">https://doi.org/10.1145/3779031.3779110</a>.
  ieee: L. Elbeheiry, M. J. Sammler, R. Krebbers, D. Dreyer, and D. Garg, “A recipe
    for modular verification of generic tree traversals,” in <i>Proceedings of the
    15th ACM SIGPLAN International Conference on Certified Programs and Proofs</i>,
    Rennes, France, 2026, pp. 339–352.
  ista: 'Elbeheiry L, Sammler MJ, Krebbers R, Dreyer D, Garg D. 2026. A recipe for
    modular verification of generic tree traversals. Proceedings of the 15th ACM SIGPLAN
    International Conference on Certified Programs and Proofs. CPP: Conference on
    Certified Programs and Proofs, 339–352.'
  mla: Elbeheiry, Laila, et al. “A Recipe for Modular Verification of Generic Tree
    Traversals.” <i>Proceedings of the 15th ACM SIGPLAN International Conference on
    Certified Programs and Proofs</i>, Association for Computing Machinery, 2026,
    pp. 339–52, doi:<a href="https://doi.org/10.1145/3779031.3779110">10.1145/3779031.3779110</a>.
  short: L. Elbeheiry, M.J. Sammler, R. Krebbers, D. Dreyer, D. Garg, in:, Proceedings
    of the 15th ACM SIGPLAN International Conference on Certified Programs and Proofs,
    Association for Computing Machinery, 2026, pp. 339–352.
conference:
  end_date: 2026-01-13
  location: Rennes, France
  name: 'CPP: Conference on Certified Programs and Proofs'
  start_date: 2026-01-12
date_created: 2026-02-01T23:01:43Z
date_published: 2026-01-08T00:00:00Z
date_updated: 2026-02-16T08:43:24Z
day: '08'
ddc:
- '000'
department:
- _id: MiSa
doi: 10.1145/3779031.3779110
file:
- access_level: open_access
  checksum: 7df99991493e907d83a197151f378e3e
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-16T08:40:29Z
  date_updated: 2026-02-16T08:40:29Z
  file_id: '21225'
  file_name: 2026_CPP_Elbeheiry.pdf
  file_size: 811872
  relation: main_file
  success: 1
file_date_updated: 2026-02-16T08:40:29Z
has_accepted_license: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 339-352
publication: Proceedings of the 15th ACM SIGPLAN International Conference on Certified
  Programs and Proofs
publication_identifier:
  isbn:
  - '9798400723414'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: A recipe for modular verification of generic tree traversals
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21135'
abstract:
- lang: eng
  text: Three-dimensional (3D) microscopy data is often anisotropic with significantly
    lower resolution (up to 8x) along the z axis than along the xy axes. Computationally
    generating plausible isotropic resolution from anisotropic imaging data would
    benefit the visual analysis of large-scale volumes. This paper proposes niiv,
    a self-supervised method for isotropic reconstruction of 3D microscopy data that
    can quickly produce images at arbitrary output resolutions. The representation
    embeds a learned latent code within a neural field that describes the implicit
    higher-resolution isotropic image region. We use an attention-guided latent interpolation
    approach, which allows flexible information exchange over a local latent neighborhood.
    Under isotropic volume assumptions, we self-supervise this representation on low-/high-resolution
    lateral image pairs to reconstruct an isotropic volume from low-resolution axial
    images. We evaluate our method on simulated and real anisotropic electron (EM)
    and light microscopy (LM) data. Compared to diffusion-based baselines, niiv shows
    improved reconstruction quality (+1 dB PSNR) and is over three orders of magnitude
    faster (1,000x) to infer. Specifically, niiv reconstructs a 128^3 voxel volume
    in 2/10th of a second, renderable at varying (continuous) high resolutions for
    display. Our code is available at https://github.com/jakobtroidl/niiv-miccai.
acknowledgement: This work was supported by NIH grants 1U01NS132158 and R01HD104969.
  We thank the reviewers for their constructive feedback.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Jakob
  full_name: Troidl, Jakob
  last_name: Troidl
- first_name: Yiqing
  full_name: Liang, Yiqing
  last_name: Liang
- first_name: Johanna
  full_name: Beyer, Johanna
  last_name: Beyer
- first_name: Mojtaba
  full_name: Tavakoli, Mojtaba
  id: 3A0A06F4-F248-11E8-B48F-1D18A9856A87
  last_name: Tavakoli
  orcid: 0000-0002-7667-6854
- first_name: Johann G
  full_name: Danzl, Johann G
  id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
  last_name: Danzl
  orcid: 0000-0001-8559-3973
- first_name: Markus
  full_name: Hadwiger, Markus
  last_name: Hadwiger
- first_name: Hanspeter
  full_name: Pfister, Hanspeter
  last_name: Pfister
- first_name: James
  full_name: Tompkin, James
  last_name: Tompkin
citation:
  ama: 'Troidl J, Liang Y, Beyer J, et al. niiv: Interactive Self-supervised Neural
    Implicit Isotropic Volume Reconstruction. In: <i>1st International Workshop on
    Efficient Medical Artificial Intelligence</i>. Vol 16318. Springer Nature; 2026:257-267.
    doi:<a href="https://doi.org/10.1007/978-3-032-13961-0_26">10.1007/978-3-032-13961-0_26</a>'
  apa: 'Troidl, J., Liang, Y., Beyer, J., Tavakoli, M., Danzl, J. G., Hadwiger, M.,
    … Tompkin, J. (2026). niiv: Interactive Self-supervised Neural Implicit Isotropic
    Volume Reconstruction. In <i>1st International Workshop on Efficient Medical Artificial
    Intelligence</i> (Vol. 16318, pp. 257–267). Daejeon, South Korea: Springer Nature.
    <a href="https://doi.org/10.1007/978-3-032-13961-0_26">https://doi.org/10.1007/978-3-032-13961-0_26</a>'
  chicago: 'Troidl, Jakob, Yiqing Liang, Johanna Beyer, Mojtaba Tavakoli, Johann G
    Danzl, Markus Hadwiger, Hanspeter Pfister, and James Tompkin. “Niiv: Interactive
    Self-Supervised Neural Implicit Isotropic Volume Reconstruction.” In <i>1st International
    Workshop on Efficient Medical Artificial Intelligence</i>, 16318:257–67. Springer
    Nature, 2026. <a href="https://doi.org/10.1007/978-3-032-13961-0_26">https://doi.org/10.1007/978-3-032-13961-0_26</a>.'
  ieee: 'J. Troidl <i>et al.</i>, “niiv: Interactive Self-supervised Neural Implicit
    Isotropic Volume Reconstruction,” in <i>1st International Workshop on Efficient
    Medical Artificial Intelligence</i>, Daejeon, South Korea, 2026, vol. 16318, pp.
    257–267.'
  ista: 'Troidl J, Liang Y, Beyer J, Tavakoli M, Danzl JG, Hadwiger M, Pfister H,
    Tompkin J. 2026. niiv: Interactive Self-supervised Neural Implicit Isotropic Volume
    Reconstruction. 1st International Workshop on Efficient Medical Artificial Intelligence.
    EMA4MICCAI: Efficient Medical Artificial Intelligence, LNCS, vol. 16318, 257–267.'
  mla: 'Troidl, Jakob, et al. “Niiv: Interactive Self-Supervised Neural Implicit Isotropic
    Volume Reconstruction.” <i>1st International Workshop on Efficient Medical Artificial
    Intelligence</i>, vol. 16318, Springer Nature, 2026, pp. 257–67, doi:<a href="https://doi.org/10.1007/978-3-032-13961-0_26">10.1007/978-3-032-13961-0_26</a>.'
  short: J. Troidl, Y. Liang, J. Beyer, M. Tavakoli, J.G. Danzl, M. Hadwiger, H. Pfister,
    J. Tompkin, in:, 1st International Workshop on Efficient Medical Artificial Intelligence,
    Springer Nature, 2026, pp. 257–267.
conference:
  end_date: 2025-09-23
  location: Daejeon, South Korea
  name: 'EMA4MICCAI: Efficient Medical Artificial Intelligence'
  start_date: 2025-09-23
date_created: 2026-02-01T23:01:44Z
date_published: 2026-01-03T00:00:00Z
date_updated: 2026-02-16T08:50:50Z
day: '03'
department:
- _id: JoDa
doi: 10.1007/978-3-032-13961-0_26
intvolume: '     16318'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1101/2024.09.07.611785
month: '01'
oa: 1
oa_version: Preprint
page: 257-267
publication: 1st International Workshop on Efficient Medical Artificial Intelligence
publication_identifier:
  eissn:
  - 1611-3349
  isbn:
  - '9783032139603'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - relation: software
    url: https://github.com/jakobtroidl/niiv-miccai
scopus_import: '1'
status: public
title: 'niiv: Interactive Self-supervised Neural Implicit Isotropic Volume Reconstruction'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16318
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21140'
abstract:
- lang: eng
  text: 'We consider several problems related to packing forests in graphs. The first
    one is to find k edge-disjoint forests in a directed graph G of maximal size such
    that the indegree of each vertex in these forests is at most k. We describe a
    min-max characterization for this problem and show that it can be solved in almost
    linear time for fixed k, extending the algorithm of [Gabow, 1995]. Specifically,
    the complexity is O(kδm log n), where n, m are the number of vertices and edges
    in G respectively, and δ = max{1, k − kG}, where kG is the edge connectivity of
    the graph. Using our solution to this problem, we improve complexities for two
    existing applications:(1) k-forest problem: find k forests in an undirected graph
    G maximizing the number of edges in their union. We show how to solve this problem
    in O(k3 min{kn, m} log2 n + k · MAXFLOW(m, m) log n) time, breaking the Ok(n3/2)
    complexity barrier of previously known approaches.(2) Directed edge-connectivity
    augmentation problem: find a smallest set of directed edges whose addition to
    the given directed graph makes it strongly k-connected. We improve the deterministic
    complexity for this problem from O(kδ(m + δn) log n) [Gabow, STOC 1994] to O(kδm
    log n). A similar approach with the same complexity also works for the undirected
    version of the problem.'
article_processing_charge: No
arxiv: 1
author:
- first_name: Pavel
  full_name: Arkhipov, Pavel
  id: b25f2ab2-1fed-11ee-8599-fe02d211784f
  last_name: Arkhipov
- first_name: Vladimir
  full_name: Kolmogorov, Vladimir
  id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87
  last_name: Kolmogorov
citation:
  ama: 'Arkhipov P, Kolmogorov V. Faster algorithms for packing forests in graphs
    and related problems. In: <i>Proceedings of the 2026 Annual ACM-SIAM Symposium
    on Discrete Algorithms</i>. Society for Industrial and Applied Mathematics; 2026:4023-4042.
    doi:<a href="https://doi.org/10.1137/1.9781611978971.148">10.1137/1.9781611978971.148</a>'
  apa: 'Arkhipov, P., &#38; Kolmogorov, V. (2026). Faster algorithms for packing forests
    in graphs and related problems. In <i>Proceedings of the 2026 Annual ACM-SIAM
    Symposium on Discrete Algorithms</i> (pp. 4023–4042). Vancouver, Canada: Society
    for Industrial and Applied Mathematics. <a href="https://doi.org/10.1137/1.9781611978971.148">https://doi.org/10.1137/1.9781611978971.148</a>'
  chicago: Arkhipov, Pavel, and Vladimir Kolmogorov. “Faster Algorithms for Packing
    Forests in Graphs and Related Problems.” In <i>Proceedings of the 2026 Annual
    ACM-SIAM Symposium on Discrete Algorithms</i>, 4023–42. Society for Industrial
    and Applied Mathematics, 2026. <a href="https://doi.org/10.1137/1.9781611978971.148">https://doi.org/10.1137/1.9781611978971.148</a>.
  ieee: P. Arkhipov and V. Kolmogorov, “Faster algorithms for packing forests in graphs
    and related problems,” in <i>Proceedings of the 2026 Annual ACM-SIAM Symposium
    on Discrete Algorithms</i>, Vancouver, Canada, 2026, pp. 4023–4042.
  ista: 'Arkhipov P, Kolmogorov V. 2026. Faster algorithms for packing forests in
    graphs and related problems. Proceedings of the 2026 Annual ACM-SIAM Symposium
    on Discrete Algorithms. SODA: Symposium on Discrete Algorithms, 4023–4042.'
  mla: Arkhipov, Pavel, and Vladimir Kolmogorov. “Faster Algorithms for Packing Forests
    in Graphs and Related Problems.” <i>Proceedings of the 2026 Annual ACM-SIAM Symposium
    on Discrete Algorithms</i>, Society for Industrial and Applied Mathematics, 2026,
    pp. 4023–42, doi:<a href="https://doi.org/10.1137/1.9781611978971.148">10.1137/1.9781611978971.148</a>.
  short: P. Arkhipov, V. Kolmogorov, in:, Proceedings of the 2026 Annual ACM-SIAM
    Symposium on Discrete Algorithms, Society for Industrial and Applied Mathematics,
    2026, pp. 4023–4042.
conference:
  end_date: 2026-01-14
  location: Vancouver, Canada
  name: 'SODA: Symposium on Discrete Algorithms'
  start_date: 2026-01-11
corr_author: '1'
date_created: 2026-02-05T10:51:34Z
date_published: 2026-01-07T00:00:00Z
date_updated: 2026-02-16T09:18:33Z
day: '07'
department:
- _id: VlKo
doi: 10.1137/1.9781611978971.148
external_id:
  arxiv:
  - '2409.20314'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2409.20314
month: '01'
oa: 1
oa_version: Preprint
page: 4023-4042
publication: Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms
publication_identifier:
  eisbn:
  - '9781611978971'
publication_status: published
publisher: Society for Industrial and Applied Mathematics
quality_controlled: '1'
status: public
title: Faster algorithms for packing forests in graphs and related problems
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
_id: '21145'
abstract:
- lang: eng
  text: 'Protein conformational energy landscapes are shaped not only by intramolecular
    interactions but also by their environment. In protein crystals and protein-protein
    complexes, intermolecular contacts alter this energy landscape, but the exact
    nature of this alteration is difficult to decipher. Understanding how the crystal
    lattice affects protein dynamics is crucial for crystallography-based studies
    of motion, yet its influence on collective motions remains unclear. Aromatic ring
    flips in the hydrophobic core represent sensitive probes of such dynamics. Here,
    we compare the kinetics of aromatic ring flips in the protein GB1 in crystals,
    in complex with its binding partner IgG, and in solution, combining advanced isotope
    labeling with quantitative NMR methods. We show that rings in the core flip nearly
    a thousand times less frequently in crystals than in solution. Enhanced-sampling
    molecular dynamics simulations, based on a new crystal structure, reproduce these
    elevated barriers and reveal how the crystal restrains motions. '
acknowledged_ssus:
- _id: NMR
- _id: LifeSc
acknowledgement: "We thank Nikolai R. Skrynnikov and Olga O. Lebedenko (St. Petersburg)
  for insightful discussions and for performing exploratory MD simulations. We are
  grateful to Tobias Schubeis (Lyon) for advice with GB1 crystallization, and Rebecca
  Schmid for initial crystallization trials.\r\nWe thank Sebastian Falkner for assistance
  with constructing the structural model of the IgG:GB1 complex.\r\nThis research
  was supported by the Scientific Service Units (SSU) of Institute of Science and
  Technology Austria (ISTA) through resources provided by the Nuclear Magnetic Resonance
  and the Lab Support Facilities. We thank Petra Rovó and Margarita Valhondo Falcón
  for excellent support of the NMR facility.\r\nLea M. Becker is recipient of a DOC
  fellowship of the Austrian Academy of Sciences at the Institute of Science and Technology
  Austria (grant no. PR10660EAW01). Christophe Chipot acknowledges the European Research
  Council (grant project 101097272 ``MilliInMicro'') and the Métropole du Grand Nancy
  (grant project ``ARC''). BM07-FIP2 is supported by the French ANR PIA3 (France 2030)
  EquipEx+ project MAGNIFIX under grant agreement ANR-21-ESRE-0011."
article_processing_charge: No
author:
- first_name: Lea Marie
  full_name: Becker, Lea Marie
  id: 36336939-eb97-11eb-a6c2-c83f1214ca79
  last_name: Becker
  orcid: 0000-0002-6401-5151
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
- first_name: Christophe
  full_name: Chipot, Christophe
  last_name: Chipot
citation:
  ama: Becker LM, Schanda P, Chipot C. Additional Data for “Aromatic Ring Flips Reveal
    Reshaping of Protein Dynamics in Crystals and Complexes.” 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-21145">10.15479/AT-ISTA-21145</a>
  apa: Becker, L. M., Schanda, P., &#38; Chipot, C. (2026). Additional Data for “Aromatic
    Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.” Institute
    of Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-21145">https://doi.org/10.15479/AT-ISTA-21145</a>
  chicago: Becker, Lea Marie, Paul Schanda, and Christophe Chipot. “Additional Data
    for ‘Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and
    Complexes.’” Institute of Science and Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-21145">https://doi.org/10.15479/AT-ISTA-21145</a>.
  ieee: L. M. Becker, P. Schanda, and C. Chipot, “Additional Data for ‘Aromatic Ring
    Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.’” Institute
    of Science and Technology Austria, 2026.
  ista: Becker LM, Schanda P, Chipot C. 2026. Additional Data for ‘Aromatic Ring Flips
    Reveal Reshaping of Protein Dynamics in Crystals and Complexes’, Institute of
    Science and Technology Austria, <a href="https://doi.org/10.15479/AT-ISTA-21145">10.15479/AT-ISTA-21145</a>.
  mla: Becker, Lea Marie, et al. <i>Additional Data for “Aromatic Ring Flips Reveal
    Reshaping of Protein Dynamics in Crystals and Complexes.”</i> Institute of Science
    and Technology Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-21145">10.15479/AT-ISTA-21145</a>.
  short: L.M. Becker, P. Schanda, C. Chipot, (2026).
contributor:
- contributor_type: researcher
  first_name: Haohao
  last_name: Fu
- contributor_type: researcher
  first_name: Benjamin
  id: 71cda2f3-e604-11ee-a1df-da10587eda3f
  last_name: Tatman
- contributor_type: researcher
  first_name: Matthias
  last_name: Dreydoppel
- contributor_type: researcher
  first_name: Anna
  id: 9fb2a840-89e1-11ee-a8b7-cc5c7ba62471
  last_name: Kapitonova
- contributor_type: researcher
  first_name: Daniel
  id: 302BADF6-85FC-11EA-9E3B-B9493DDC885E
  last_name: Balazs
  orcid: 0000-0001-7597-043X
- contributor_type: researcher
  first_name: Ulrich
  last_name: Weininger
- contributor_type: researcher
  first_name: Sylvain
  last_name: Engilberge
corr_author: '1'
date_created: 2026-02-05T13:54:39Z
date_published: 2026-02-09T00:00:00Z
date_updated: 2026-02-18T10:04:44Z
day: '09'
ddc:
- '572'
department:
- _id: GradSch
- _id: PaSc
doi: 10.15479/AT-ISTA-21145
file:
- access_level: open_access
  checksum: 02a419cce8cea450bc952f35488d2df5
  content_type: text/plain
  creator: lbecker
  date_created: 2026-02-05T13:52:37Z
  date_updated: 2026-02-05T13:52:37Z
  file_id: '21146'
  file_name: README.txt
  file_size: 4263
  relation: table_of_contents
- access_level: open_access
  checksum: b0b82b1aa73985b0b308a3fa52d21aea
  content_type: application/zip
  creator: lbecker
  date_created: 2026-02-05T13:52:41Z
  date_updated: 2026-02-05T13:52:41Z
  file_id: '21147'
  file_name: Research_Data.zip
  file_size: 50647107
  relation: main_file
  success: 1
file_date_updated: 2026-02-05T13:52:41Z
has_accepted_license: '1'
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: 7be609c4-9f16-11ee-852c-85015ce2b9b0
  grant_number: '26777'
  name: Exploring protein dynamics by solid-state MAS NMR through specific labeling
    approaches
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '20641'
    relation: earlier_version
    status: public
status: public
title: Additional Data for "Aromatic Ring Flips Reveal Reshaping of Protein Dynamics
  in Crystals and Complexes"
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21149'
abstract:
- lang: eng
  text: We present a general theoretical framework for helical dichroism (HD), establishing
    an explicit link between chiral resolution and orbital angular momentum (OAM)
    exchange in light–matter interaction. Tracing microscopic mechanisms of the OAM
    transfer, we derive rotational selection rules, which establish that HD emerges
    only from the spin–orbit coupling of light, even for beams without the far-field
    OAM. Our findings refine the conditions for observing HD, provide a tool to re-examine
    the outcome of prior experiments, and guide future designs for chiral sensing
    with structured light.
acknowledgement: This research was funded in whole or in part by the Austrian Science
  Fund (FWF) [10.55776/F1004].
article_number: '053204'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Mateja
  full_name: Hrast, Mateja
  id: 48dbb294-2a9c-11ef-905d-f56be71f0e5d
  last_name: Hrast
- first_name: Georgios
  full_name: Koutentakis, Georgios
  id: d7b23d3a-9e21-11ec-b482-f76739596b95
  last_name: Koutentakis
- first_name: Mikhail
  full_name: Maslov, Mikhail
  id: 2E65BB0E-F248-11E8-B48F-1D18A9856A87
  last_name: Maslov
  orcid: 0000-0003-4074-2570
- first_name: Mikhail
  full_name: Lemeshko, Mikhail
  id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
  last_name: Lemeshko
  orcid: 0000-0002-6990-7802
citation:
  ama: Hrast M, Koutentakis G, Maslov M, Lemeshko M. Bottom-up analysis of rovibrational
    helical dichroism. <i>Physical Review Letters</i>. 2026;136(5). doi:<a href="https://doi.org/10.1103/fkf1-1jml">10.1103/fkf1-1jml</a>
  apa: Hrast, M., Koutentakis, G., Maslov, M., &#38; Lemeshko, M. (2026). Bottom-up
    analysis of rovibrational helical dichroism. <i>Physical Review Letters</i>. American
    Physical Society. <a href="https://doi.org/10.1103/fkf1-1jml">https://doi.org/10.1103/fkf1-1jml</a>
  chicago: Hrast, Mateja, Georgios Koutentakis, Mikhail Maslov, and Mikhail Lemeshko.
    “Bottom-up Analysis of Rovibrational Helical Dichroism.” <i>Physical Review Letters</i>.
    American Physical Society, 2026. <a href="https://doi.org/10.1103/fkf1-1jml">https://doi.org/10.1103/fkf1-1jml</a>.
  ieee: M. Hrast, G. Koutentakis, M. Maslov, and M. Lemeshko, “Bottom-up analysis
    of rovibrational helical dichroism,” <i>Physical Review Letters</i>, vol. 136,
    no. 5. American Physical Society, 2026.
  ista: Hrast M, Koutentakis G, Maslov M, Lemeshko M. 2026. Bottom-up analysis of
    rovibrational helical dichroism. Physical Review Letters. 136(5), 053204.
  mla: Hrast, Mateja, et al. “Bottom-up Analysis of Rovibrational Helical Dichroism.”
    <i>Physical Review Letters</i>, vol. 136, no. 5, 053204, American Physical Society,
    2026, doi:<a href="https://doi.org/10.1103/fkf1-1jml">10.1103/fkf1-1jml</a>.
  short: M. Hrast, G. Koutentakis, M. Maslov, M. Lemeshko, Physical Review Letters
    136 (2026).
corr_author: '1'
date_created: 2026-02-06T10:53:17Z
date_published: 2026-02-05T00:00:00Z
date_updated: 2026-02-10T11:30:37Z
day: '05'
ddc:
- '530'
department:
- _id: MiLe
doi: 10.1103/fkf1-1jml
external_id:
  arxiv:
  - '2505.16393'
file:
- access_level: open_access
  checksum: 805c929fff9fd4d0e733293eaace67b8
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-10T11:25:46Z
  date_updated: 2026-02-10T11:25:46Z
  file_id: '21210'
  file_name: 2026_PhysicalReviewLetters_Hrast.pdf
  file_size: 511312
  relation: main_file
  success: 1
file_date_updated: 2026-02-10T11:25:46Z
has_accepted_license: '1'
intvolume: '       136'
issue: '5'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: 7c040762-9f16-11ee-852c-dd79eeee4ab3
  grant_number: F100403
  name: Coherent Optical Metrology Beyond Electric-Dipole-Allowed Transitions
publication: Physical Review Letters
publication_identifier:
  eissn:
  - 1079-7114
  issn:
  - 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Bottom-up analysis of rovibrational helical dichroism
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 136
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21158'
abstract:
- lang: eng
  text: Vernalization-regulated flowering is vital for wheat yield and geographical
    distribution, and the diversity of flowering time genes is essential for the breeding
    of climate-resilient varieties. Sugars have long been recognized in regulating
    flowering; however, the intrinsic connection between carbohydrate metabolism and
    vernalization response remains largely unexplored. Here, we identify a fructose
    1,6-bisphosphate aldolase (FBA) encoding gene, HtL1/FBA10, as a modulator of heading
    time variation based on a genome-wide association study utilizing wheat core germplasm
    collections. Evolutionary analysis shows a decrease in the proportion of haplotype-2
    of HtL1, which is linked to delayed flowering, in Chinese and American wheat varieties
    compared to landraces. Vernalization reduces HtL1/FBA10 phosphorylation levels
    and  increases  its O-GlcNAcylation, which in turn enhances its enzymatic activity
    and facilitates VERNALIZATION 1 (VRN1) transcription by regulating histone acetylation
    at the VRN1 locus. Our findings provide mechanistic insights into the interplay
    between glucose metabolism and the epigenetic regulation of vernalization in winter
    wheat.
acknowledgement: This work was supported by the Basic Science Center Project of National
  Natural Science Foundation of China (32388201) to K.C and the National Natural Science
  Foundation of China (31970331) to L.X. We thank Dr. Zhuang Lu, Dr. Bin Han and Ms.
  Jingquan Li (Plant Science Facility of the Institute of Botany, Chinese Academy
  of Sciences) for their technical assistance in LC-MS/MS assay, small molecule compound
  analysis and the subcellular localization assay, respectively. We thank Dr. Wei
  Luo and Dr. Dongfeng Liu for helpful discussions.
article_number: '999'
article_processing_charge: Yes
article_type: original
author:
- first_name: Pengfang
  full_name: Yang, Pengfang
  last_name: Yang
- first_name: Yangyang
  full_name: Liu, Yangyang
  last_name: Liu
- first_name: Qi
  full_name: Dong, Qi
  last_name: Dong
- first_name: Yuting
  full_name: Miao, Yuting
  last_name: Miao
- first_name: Jianlong
  full_name: Zhang, Jianlong
  last_name: Zhang
- first_name: Shujuan
  full_name: Xu, Shujuan
  id: 9724dd9d-f591-11ee-bd51-e97ed0652286
  last_name: Xu
- first_name: Hong
  full_name: Zhao, Hong
  last_name: Zhao
- first_name: Yuda
  full_name: Niu, Yuda
  last_name: Niu
- first_name: Xueyong
  full_name: Zhang, Xueyong
  last_name: Zhang
- first_name: Yunyuan
  full_name: Xu, Yunyuan
  last_name: Xu
- first_name: Zifeng
  full_name: Guo, Zifeng
  last_name: Guo
- first_name: Lijing
  full_name: Xing, Lijing
  last_name: Xing
- first_name: Kang
  full_name: Chong, Kang
  last_name: Chong
citation:
  ama: Yang P, Liu Y, Dong Q, et al. O-GlcNAc and phosphorylation modifications on
    HtL1/FBA10 regulate wheat vernalization for flowering. <i>Nature Communications</i>.
    2026;17. doi:<a href="https://doi.org/10.1038/s41467-025-67734-0">10.1038/s41467-025-67734-0</a>
  apa: Yang, P., Liu, Y., Dong, Q., Miao, Y., Zhang, J., Xu, S., … Chong, K. (2026).
    O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization
    for flowering. <i>Nature Communications</i>. Springer Nature. <a href="https://doi.org/10.1038/s41467-025-67734-0">https://doi.org/10.1038/s41467-025-67734-0</a>
  chicago: Yang, Pengfang, Yangyang Liu, Qi Dong, Yuting Miao, Jianlong Zhang, Shujuan
    Xu, Hong Zhao, et al. “O-GlcNAc and Phosphorylation Modifications on HtL1/FBA10
    Regulate Wheat Vernalization for Flowering.” <i>Nature Communications</i>. Springer
    Nature, 2026. <a href="https://doi.org/10.1038/s41467-025-67734-0">https://doi.org/10.1038/s41467-025-67734-0</a>.
  ieee: P. Yang <i>et al.</i>, “O-GlcNAc and phosphorylation modifications on HtL1/FBA10
    regulate wheat vernalization for flowering,” <i>Nature Communications</i>, vol.
    17. Springer Nature, 2026.
  ista: Yang P, Liu Y, Dong Q, Miao Y, Zhang J, Xu S, Zhao H, Niu Y, Zhang X, Xu Y,
    Guo Z, Xing L, Chong K. 2026. O-GlcNAc and phosphorylation modifications on HtL1/FBA10
    regulate wheat vernalization for flowering. Nature Communications. 17, 999.
  mla: Yang, Pengfang, et al. “O-GlcNAc and Phosphorylation Modifications on HtL1/FBA10
    Regulate Wheat Vernalization for Flowering.” <i>Nature Communications</i>, vol.
    17, 999, Springer Nature, 2026, doi:<a href="https://doi.org/10.1038/s41467-025-67734-0">10.1038/s41467-025-67734-0</a>.
  short: P. Yang, Y. Liu, Q. Dong, Y. Miao, J. Zhang, S. Xu, H. Zhao, Y. Niu, X. Zhang,
    Y. Xu, Z. Guo, L. Xing, K. Chong, Nature Communications 17 (2026).
date_created: 2026-02-08T23:02:48Z
date_published: 2026-01-27T00:00:00Z
date_updated: 2026-02-12T14:34:24Z
day: '27'
ddc:
- '580'
department:
- _id: XiFe
doi: 10.1038/s41467-025-67734-0
external_id:
  pmid:
  - '41455723'
file:
- access_level: open_access
  checksum: 9ae170ec70ba1ab56b6f1ffe67d1de7f
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-12T14:33:14Z
  date_updated: 2026-02-12T14:33:14Z
  file_id: '21223'
  file_name: 2026_NatureComm_Yang.pdf
  file_size: 4685882
  relation: main_file
  success: 1
file_date_updated: 2026-02-12T14:33:14Z
has_accepted_license: '1'
intvolume: '        17'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization
  for flowering
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21159'
abstract:
- lang: eng
  text: "One of the foundational theorems of extremal graph theory is Dirac’s theorem,
    which\r\nsays that if an n-vertex graph G has minimum degree at least n/2, then
    G has a\r\nHamilton cycle, and therefore a perfect matching (if n is even). Later
    work by Sárközy,\r\nSelkow and Szemerédi showed that in fact Dirac graphs have
    many Hamilton cycles\r\nand perfect matchings, culminating in a result of Cuckler
    and Kahn that gives a precise\r\ndescription of the numbers of Hamilton cycles
    and perfect matchings in a Dirac graph\r\nG (in terms of an entropy-like parameter
    of G). In this paper we extend Cuckler\r\nand Kahn’s result to perfect matchings
    in hypergraphs. For positive integers d < k,\r\nand for n divisible by k, let
    md (k, n) be the minimum d-degree that ensures the\r\nexistence of a perfect matching
    in an n-vertex k-uniform hypergraph. In general, it is\r\nan open question to
    determine (even asymptotically) the values of md (k, n), but we are\r\nnonetheless
    able to prove an analogue of the Cuckler–Kahn theorem, showing that if\r\nan n-vertex
    k-uniform hypergraph G has minimum d-degree at least (1+γ )md (k, n)\r\n(for any
    constantγ > 0), then the number of perfect matchings in G is controlled by\r\nan
    entropy-like parameter of G. This strengthens cruder estimates arising from work\r\nof
    Kang–Kelly–Kühn–Osthus–Pfenninger and Pham–Sah–Sawhney–Simkin."
acknowledgement: We would like to thank the referees for a number of helpful comments
  and suggestions, which have substantially improved the paper. Open access funding
  provided by Institute of Science and Technology (IST Austria).
article_number: '5'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Matthew Alan
  full_name: Kwan, Matthew Alan
  id: 5fca0887-a1db-11eb-95d1-ca9d5e0453b3
  last_name: Kwan
  orcid: 0000-0002-4003-7567
- first_name: Roodabeh
  full_name: Safavi Hemami, Roodabeh
  id: 72ed2640-8972-11ed-ae7b-f9c81ec75154
  last_name: Safavi Hemami
- first_name: Yiting
  full_name: Wang, Yiting
  id: 1917d194-076e-11ed-97cd-837255f88785
  last_name: Wang
  orcid: 0000-0002-2856-767X
citation:
  ama: Kwan MA, Safavi Hemami R, Wang Y. Counting perfect matchings in Dirac hypergraphs.
    <i>Combinatorica</i>. 2026;46. doi:<a href="https://doi.org/10.1007/s00493-025-00194-8">10.1007/s00493-025-00194-8</a>
  apa: Kwan, M. A., Safavi Hemami, R., &#38; Wang, Y. (2026). Counting perfect matchings
    in Dirac hypergraphs. <i>Combinatorica</i>. Springer Nature. <a href="https://doi.org/10.1007/s00493-025-00194-8">https://doi.org/10.1007/s00493-025-00194-8</a>
  chicago: Kwan, Matthew Alan, Roodabeh Safavi Hemami, and Yiting Wang. “Counting
    Perfect Matchings in Dirac Hypergraphs.” <i>Combinatorica</i>. Springer Nature,
    2026. <a href="https://doi.org/10.1007/s00493-025-00194-8">https://doi.org/10.1007/s00493-025-00194-8</a>.
  ieee: M. A. Kwan, R. Safavi Hemami, and Y. Wang, “Counting perfect matchings in
    Dirac hypergraphs,” <i>Combinatorica</i>, vol. 46. Springer Nature, 2026.
  ista: Kwan MA, Safavi Hemami R, Wang Y. 2026. Counting perfect matchings in Dirac
    hypergraphs. Combinatorica. 46, 5.
  mla: Kwan, Matthew Alan, et al. “Counting Perfect Matchings in Dirac Hypergraphs.”
    <i>Combinatorica</i>, vol. 46, 5, Springer Nature, 2026, doi:<a href="https://doi.org/10.1007/s00493-025-00194-8">10.1007/s00493-025-00194-8</a>.
  short: M.A. Kwan, R. Safavi Hemami, Y. Wang, Combinatorica 46 (2026).
corr_author: '1'
date_created: 2026-02-08T23:02:49Z
date_published: 2026-02-01T00:00:00Z
date_updated: 2026-02-16T09:55:17Z
day: '01'
ddc:
- '510'
department:
- _id: MaKw
- _id: MoHe
doi: 10.1007/s00493-025-00194-8
external_id:
  arxiv:
  - '2408.09589'
file:
- access_level: open_access
  checksum: 47b0031d90b0e6b9a843f422a1486089
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-16T09:52:38Z
  date_updated: 2026-02-16T09:52:38Z
  file_id: '21228'
  file_name: 2026_Combinatorica_Kwan.pdf
  file_size: 539646
  relation: main_file
  success: 1
file_date_updated: 2026-02-16T09:52:38Z
has_accepted_license: '1'
intvolume: '        46'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
publication: Combinatorica
publication_identifier:
  eissn:
  - 1439-6912
  issn:
  - 0209-9683
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Counting perfect matchings in Dirac hypergraphs
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 46
year: '2026'
...
---
OA_place: publisher
OA_type: diamond
PlanS_conform: '1'
_id: '21160'
abstract:
- lang: eng
  text: "Context. AM Canum Venaticorum (AM CVn) stars are ultra-compact binary systems
    composed of a white dwarf primary accreting from a hydrogen-deficient donor. They
    play a crucial role in astrophysics as potential progenitors of Type Ia supernovae
    and as laboratories for gravitational wave studies. However, their formation and
    evolutionary history remain incomplete. Three formation channels have been discussed
    in the literature: the white dwarf, He-star, and cataclysmic variable channels.\r\n\r\nAims.
    The chemical composition of the accretor atmosphere reflects the material transferred
    from the donor. In this work we took the first accurate measurements of the fundamental
    parameters of the accreting white dwarf in ZTF J225237.05−051917.4, including
    the abundances of key elements such as carbon, nitrogen, and silicon, by analysing
    ultraviolet spectra obtained with the Hubble Space Telescope (HST). These measurements
    provide new insight into the evolutionary history of the system and, together
    with existing optical observations, establish it as a benchmark to develop our
    pipeline, paving the way for its application to a larger sample of AM CVn systems.\r\n\r\nMethods.
    We determined the binary parameters through photometric analysis and constrained
    the atmospheric parameters of the white dwarf accretor, including its effective
    temperature, surface gravity, and chemical abundances, by fitting the HST ultraviolet
    spectrum with synthetic spectral models. We then inferred the system’s formation
    channel by comparing the results with theoretical evolutionary models.\r\n\r\nResults.
    According to our measurements, the accretor’s effective temperature (Teff) is
    23 300 ± 600 K and the surface gravity (log g) is 8.4 ± 0.3, which imply an accretor
    mass (MWD) of 0.86 ± 0.16 M⊙. We find a high nitrogen-to-carbon abundance ratio
    by mass of > 153.\r\n\r\nConclusions. The accretor is significantly hotter than
    previous estimates based on simplified blackbody fits to the spectral energy distribution,
    underscoring the importance of detailed spectral modelling for accurately determining
    system parameters. Our results show that ultraviolet spectroscopy is well suited
    to constraining the formation channels of AM CVn systems. Of the three proposed
    formation channels, the He-star channel can be excluded given the high nitrogen-to-carbon
    ratio. Our results are consistent with both the white dwarf and cataclysmic variable
    channels."
acknowledgement: "We thank Lars Bildsten for valuable insights and discussions. We
  acknowledge with thanks the variable star observations from the\r\nAAVSO International
  Database contributed by observers worldwide and used in this research. We thank
  the members of the Spanish Observers of Supernovae\r\n(ObSN) group for their valuable
  photometric contributions. This research was\r\nsupported by Deutsche Forschungsgemeinschaft
  (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC 2121
  “Quantum Universe”\r\n– 390833306. Co-funded by the European Union (ERC, CompactBINARIES,\r\n101078773).
  Views and opinions expressed are however those of the author(s)\r\nonly and do not
  necessarily reflect those of the European Union or the European Research Council.
  Neither the European Union nor the granting authority\r\ncan be held responsible
  for them. DB acknowledges support from the São Paulo\r\nResearch Foundation (FAPESP),
  Brazil, Process Numbers #2024/03736-2 and\r\n#2025/00817-4. MRS is supported by
  Fondecyt (grant 1221059). MJG acknowledges support from the European Research Council
  through ERC Advanced\r\nGrant No. 101054731, from the National Aeronautics and Space
  Administration under grants 80NSSC24K0436, 80NSSC22K0479, and 80NSSC24K0380,\r\nand
  from the National Science Foundation under grant AST-2205736. PJG\r\nis supported
  by NRF SARChI grant 111692. PR-G acknowledges support by\r\nthe Agencia Estatal
  de Investigación del Ministerio de Ciencia e Innovación\r\n(MCIN/AEI) and the European
  Regional Development Fund (ERDF) under grant\r\nPID2021–124879NB–I00. DS is supported
  by the UK Science and Technology Facilities Council (STFC, grant numbers ST/T007184/1,
  ST/T003103/1,\r\nand ST/T000406/1). OT acknowledges Proyectos Internos USM 2025,
  PI-LII2025-03. GT was supported by grants IN109723 from the Programa de Apoyo a\r\nProyectos
  de Investigación e Innovación Tecnológica (PAPIIT). This project has\r\nreceived
  funding from the European Research Council (ERC) under the European Union’s Horizon
  2020 research and innovation programme (Grant agreement No. 101020057)."
article_number: A14
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: W.
  full_name: Yu, W.
  last_name: Yu
- first_name: A. F.
  full_name: Pala, A. F.
  last_name: Pala
- first_name: T.
  full_name: Kupfer, T.
  last_name: Kupfer
- first_name: B. T.
  full_name: Gänsicke, B. T.
  last_name: Gänsicke
- first_name: D.
  full_name: Koester, D.
  last_name: Koester
- first_name: D.
  full_name: Belloni, D.
  last_name: Belloni
- first_name: T. L.S.
  full_name: Wong, T. L.S.
  last_name: Wong
- first_name: M. R.
  full_name: Schreiber, M. R.
  last_name: Schreiber
- first_name: Joannes C
  full_name: van Roestel, Joannes C
  id: 4d122fc8-6083-11f0-87a5-97d68b860333
  last_name: van Roestel
- first_name: A. J.
  full_name: Brown, A. J.
  last_name: Brown
- first_name: E. O.
  full_name: Waagen, E. O.
  last_name: Waagen
- first_name: J. L.
  full_name: González-Carballo, J. L.
  last_name: González-Carballo
- first_name: S.
  full_name: Bednarz, S.
  last_name: Bednarz
- first_name: K.
  full_name: Bernacki, K.
  last_name: Bernacki
- first_name: D.
  full_name: De Martino, D.
  last_name: De Martino
- first_name: E.
  full_name: Fernández Mañanes, E.
  last_name: Fernández Mañanes
- first_name: R.
  full_name: González Farfán, R.
  last_name: González Farfán
- first_name: M. J.
  full_name: Green, M. J.
  last_name: Green
- first_name: P. J.
  full_name: Groot, P. J.
  last_name: Groot
- first_name: F. J.
  full_name: Hambsch, F. J.
  last_name: Hambsch
- first_name: C.
  full_name: Knigge, C.
  last_name: Knigge
- first_name: J. L.
  full_name: Martin-Velasco, J. L.
  last_name: Martin-Velasco
- first_name: M.
  full_name: Morales-Aimar, M.
  last_name: Morales-Aimar
- first_name: G.
  full_name: Myers, G.
  last_name: Myers
- first_name: R.
  full_name: Naves Nogues, R.
  last_name: Naves Nogues
- first_name: R.
  full_name: Poggiani, R.
  last_name: Poggiani
- first_name: A.
  full_name: Popowicz, A.
  last_name: Popowicz
- first_name: G.
  full_name: Ramsay, G.
  last_name: Ramsay
- first_name: E.
  full_name: Reina-Lorenz, E.
  last_name: Reina-Lorenz
- first_name: P.
  full_name: Rodríguez-Gil, P.
  last_name: Rodríguez-Gil
- first_name: J. L.
  full_name: Salto-González, J. L.
  last_name: Salto-González
- first_name: E. M.
  full_name: Sion, E. M.
  last_name: Sion
- first_name: D.
  full_name: Steeghs, D.
  last_name: Steeghs
- first_name: P.
  full_name: Szkody, P.
  last_name: Szkody
- first_name: O.
  full_name: Toloza, O.
  last_name: Toloza
- first_name: G.
  full_name: Tovmassian, G.
  last_name: Tovmassian
citation:
  ama: 'Yu W, Pala AF, Kupfer T, et al. The evolutionary history of ultra-compact
    accreting binaries: I. Chemical abundances and the formation channel of the eclipsing
    AM CVn system ZTF J225237.05-051917.4 from HST spectroscopy. <i>Astronomy and
    Astrophysics</i>. 2026;706. doi:<a href="https://doi.org/10.1051/0004-6361/202557568">10.1051/0004-6361/202557568</a>'
  apa: 'Yu, W., Pala, A. F., Kupfer, T., Gänsicke, B. T., Koester, D., Belloni, D.,
    … Tovmassian, G. (2026). The evolutionary history of ultra-compact accreting binaries:
    I. Chemical abundances and the formation channel of the eclipsing AM CVn system
    ZTF J225237.05-051917.4 from HST spectroscopy. <i>Astronomy and Astrophysics</i>.
    EDP Sciences. <a href="https://doi.org/10.1051/0004-6361/202557568">https://doi.org/10.1051/0004-6361/202557568</a>'
  chicago: 'Yu, W., A. F. Pala, T. Kupfer, B. T. Gänsicke, D. Koester, D. Belloni,
    T. L.S. Wong, et al. “The Evolutionary History of Ultra-Compact Accreting Binaries:
    I. Chemical Abundances and the Formation Channel of the Eclipsing AM CVn System
    ZTF J225237.05-051917.4 from HST Spectroscopy.” <i>Astronomy and Astrophysics</i>.
    EDP Sciences, 2026. <a href="https://doi.org/10.1051/0004-6361/202557568">https://doi.org/10.1051/0004-6361/202557568</a>.'
  ieee: 'W. Yu <i>et al.</i>, “The evolutionary history of ultra-compact accreting
    binaries: I. Chemical abundances and the formation channel of the eclipsing AM
    CVn system ZTF J225237.05-051917.4 from HST spectroscopy,” <i>Astronomy and Astrophysics</i>,
    vol. 706. EDP Sciences, 2026.'
  ista: 'Yu W, Pala AF, Kupfer T, Gänsicke BT, Koester D, Belloni D, Wong TLS, Schreiber
    MR, van Roestel JC, Brown AJ, Waagen EO, González-Carballo JL, Bednarz S, Bernacki
    K, De Martino D, Fernández Mañanes E, González Farfán R, Green MJ, Groot PJ, Hambsch
    FJ, Knigge C, Martin-Velasco JL, Morales-Aimar M, Myers G, Naves Nogues R, Poggiani
    R, Popowicz A, Ramsay G, Reina-Lorenz E, Rodríguez-Gil P, Salto-González JL, Sion
    EM, Steeghs D, Szkody P, Toloza O, Tovmassian G. 2026. The evolutionary history
    of ultra-compact accreting binaries: I. Chemical abundances and the formation
    channel of the eclipsing AM CVn system ZTF J225237.05-051917.4 from HST spectroscopy.
    Astronomy and Astrophysics. 706, A14.'
  mla: 'Yu, W., et al. “The Evolutionary History of Ultra-Compact Accreting Binaries:
    I. Chemical Abundances and the Formation Channel of the Eclipsing AM CVn System
    ZTF J225237.05-051917.4 from HST Spectroscopy.” <i>Astronomy and Astrophysics</i>,
    vol. 706, A14, EDP Sciences, 2026, doi:<a href="https://doi.org/10.1051/0004-6361/202557568">10.1051/0004-6361/202557568</a>.'
  short: W. Yu, A.F. Pala, T. Kupfer, B.T. Gänsicke, D. Koester, D. Belloni, T.L.S.
    Wong, M.R. Schreiber, J.C. van Roestel, A.J. Brown, E.O. Waagen, J.L. González-Carballo,
    S. Bednarz, K. Bernacki, D. De Martino, E. Fernández Mañanes, R. González Farfán,
    M.J. Green, P.J. Groot, F.J. Hambsch, C. Knigge, J.L. Martin-Velasco, M. Morales-Aimar,
    G. Myers, R. Naves Nogues, R. Poggiani, A. Popowicz, G. Ramsay, E. Reina-Lorenz,
    P. Rodríguez-Gil, J.L. Salto-González, E.M. Sion, D. Steeghs, P. Szkody, O. Toloza,
    G. Tovmassian, Astronomy and Astrophysics 706 (2026).
date_created: 2026-02-08T23:02:49Z
date_published: 2026-02-01T00:00:00Z
date_updated: 2026-02-16T09:36:24Z
day: '01'
ddc:
- '520'
department:
- _id: IlCa
doi: 10.1051/0004-6361/202557568
external_id:
  arxiv:
  - '2512.04147'
file:
- access_level: open_access
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  creator: dernst
  date_created: 2026-02-16T09:33:56Z
  date_updated: 2026-02-16T09:33:56Z
  file_id: '21227'
  file_name: 2026_AstronomyAstrophysics_Yu.pdf
  file_size: 4020466
  relation: main_file
  success: 1
file_date_updated: 2026-02-16T09:33:56Z
has_accepted_license: '1'
intvolume: '       706'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
publication: Astronomy and Astrophysics
publication_identifier:
  eissn:
  - 1432-0746
  issn:
  - 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The evolutionary history of ultra-compact accreting binaries: I. Chemical
  abundances and the formation channel of the eclipsing AM CVn system ZTF J225237.05-051917.4
  from HST spectroscopy'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 706
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21161'
abstract:
- lang: eng
  text: In many species, sex-biased expression is widespread and thought to contribute
    to sexual dimorphism. While bulk RNA-sequencing has been instrumental in identifying
    strongly sex-biased genes, it lacks resolution to assess variation across cell-types
    and tissue compartments. Using single-nucleus expression data from the Fly Cell
    Atlas, we investigate sex differences in adult Drosophila melanogaster. We find
    that differences in cell-type composition between the sexes are not a major source
    of sex-bias, as for the vast majority of genes, the degree of sex-bias is similar
    regardless of whether sex differences in cell-type composition are controlled
    for or not. Our analysis confirms a deficit of X-linked male-biased genes in the
    body’s somatic tissues that is widespread across cell-types. We also find the
    excess of X-linked female-biased genes to be associated with nervous system cells
    in the head but with epithelial cells in the body’s somatic tissues, showing that
    single-nucleus data crucially resolves sex-bias at the cell-type level. We investigate
    dosage compensation (DC) across 15 tissues and 17 cell-types. We observe that
    it varies throughout the body. Surprisingly, we observe a lack of DC in a cluster
    of main cells within the male accessory glands. This result highlights the importance
    of understanding context-dependent DC.
acknowledged_ssus:
- _id: ScienComp
- _id: Bio
acknowledgement: This work was partly funded by an Austrian Science Foundation FWF
  ESPRIT fellowship (10.55776/ESP6331524) to C.B. We would like to thank the Vicoso
  group for their invaluable input and discussions throughout this work. We thank
  Filip Ruzicka for his insightful comments on the manuscript. All computational resources
  were provided by the Scientific Computing Unit at ISTA. This research was also supported
  through resources provided by the Imaging & Optics Facility (IOF) at ISTA.
article_number: '20252471'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Carolina
  full_name: De Castro Barbosa Rodrigues Barata, Carolina
  id: 20565186-803f-11ed-ab7e-96a4ff7694ef
  last_name: De Castro Barbosa Rodrigues Barata
  orcid: 0000-0003-1945-2245
- first_name: Beatriz
  full_name: Vicoso, Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
citation:
  ama: de Castro Barbosa Rodrigues Barata C, Vicoso B. Single-nucleus resolution of
    sex-biased expression and dosage compensation in Drosophila melanogaster. <i>Proceedings
    of the Royal Society B Biological Sciences</i>. 2026;293(2063). doi:<a href="https://doi.org/10.1098/rspb.2025.2471">10.1098/rspb.2025.2471</a>
  apa: de Castro Barbosa Rodrigues Barata, C., &#38; Vicoso, B. (2026). Single-nucleus
    resolution of sex-biased expression and dosage compensation in Drosophila melanogaster.
    <i>Proceedings of the Royal Society B Biological Sciences</i>. Royal Society of
    London. <a href="https://doi.org/10.1098/rspb.2025.2471">https://doi.org/10.1098/rspb.2025.2471</a>
  chicago: Castro Barbosa Rodrigues Barata, Carolina de, and Beatriz Vicoso. “Single-Nucleus
    Resolution of Sex-Biased Expression and Dosage Compensation in Drosophila Melanogaster.”
    <i>Proceedings of the Royal Society B Biological Sciences</i>. Royal Society of
    London, 2026. <a href="https://doi.org/10.1098/rspb.2025.2471">https://doi.org/10.1098/rspb.2025.2471</a>.
  ieee: C. de Castro Barbosa Rodrigues Barata and B. Vicoso, “Single-nucleus resolution
    of sex-biased expression and dosage compensation in Drosophila melanogaster,”
    <i>Proceedings of the Royal Society B Biological Sciences</i>, vol. 293, no. 2063.
    Royal Society of London, 2026.
  ista: de Castro Barbosa Rodrigues Barata C, Vicoso B. 2026. Single-nucleus resolution
    of sex-biased expression and dosage compensation in Drosophila melanogaster. Proceedings
    of the Royal Society B Biological Sciences. 293(2063), 20252471.
  mla: de Castro Barbosa Rodrigues Barata, Carolina, and Beatriz Vicoso. “Single-Nucleus
    Resolution of Sex-Biased Expression and Dosage Compensation in Drosophila Melanogaster.”
    <i>Proceedings of the Royal Society B Biological Sciences</i>, vol. 293, no. 2063,
    20252471, Royal Society of London, 2026, doi:<a href="https://doi.org/10.1098/rspb.2025.2471">10.1098/rspb.2025.2471</a>.
  short: C. de Castro Barbosa Rodrigues Barata, B. Vicoso, Proceedings of the Royal
    Society B Biological Sciences 293 (2026).
corr_author: '1'
date_created: 2026-02-08T23:02:49Z
date_published: 2026-01-28T00:00:00Z
date_updated: 2026-02-16T09:27:33Z
day: '28'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1098/rspb.2025.2471
external_id:
  pmid:
  - '41592777'
file:
- access_level: open_access
  checksum: d76afebca0a6f112df0146ae2d929f36
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-16T09:26:02Z
  date_updated: 2026-02-16T09:26:02Z
  file_id: '21226'
  file_name: 2026_RoyalSocPubProceedingsB_Barata.pdf
  file_size: 2230841
  relation: main_file
  success: 1
file_date_updated: 2026-02-16T09:26:02Z
has_accepted_license: '1'
intvolume: '       293'
issue: '2063'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 90ef7108-16d5-11f0-9cad-e6e116913473
  grant_number: ESP 6331524
  name: Does genetic drift set a limit on the adaptive evolution of sex-biased expression?
publication: Proceedings of the Royal Society B Biological Sciences
publication_identifier:
  eissn:
  - 1471-2954
publication_status: published
publisher: Royal Society of London
quality_controlled: '1'
scopus_import: '1'
status: public
title: Single-nucleus resolution of sex-biased expression and dosage compensation
  in Drosophila melanogaster
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 293
year: '2026'
...
---
_id: '21164'
abstract:
- lang: eng
  text: 'Global emission inventories often fail to capture the complexities of vehicular
    pollution in regions with unique fuel mixes, such as Brazil’s extensive biofuel
    use, leading to significant uncertainties in atmospheric modeling. This study
    presents a century-long (1960–2100) bottom-up vehicular emission inventory for
    Brazil, leveraging locally derived emission factors. Our estimates reveal substantial
    discrepancies in magnitude, timing, and speciation of non-CO2 pollutants (CO,
    NMHC, PM2.5) compared to leading global inventories (EDGAR, CEDS, CAMS), highlighting
    critical inaccuracies in widely used data sets. More critically, future projections
    under Shared Socioeconomic Pathways (SSPs) uncover a novel positive feedback mechanism:
    rising temperatures significantly enhance vehicular evaporative nonmethane hydrocarbon
    (NMHC) emissions. This temperature-dependent increase and subsequent NMHC oxidation
    to CO2 suggest an overlooked pathway that could amplify climate warming and air
    pollution globally, particularly after a breakpoint around 2050 (p < 0.05). While
    historical emissions peaked in the 1990s–2000s, nonexhaust PM becomes increasingly
    important. Air quality simulations using our inventory in the MUSICA model show
    good regional PM2.5 agreement but highlight challenges in resolving local primary
    pollutant peaks. This comprehensive inventory provides crucial data for Brazil
    and uncovers globally relevant climate–chemistry interactions, urging a re-evaluation
    of regional specificities in global emission assessments.'
acknowledgement: Part of this material is based upon work supported by the NSF National
  Center for Atmospheric Research, which is a major facility sponsored by the National
  Science Foundation under Cooperative Agreement No. 1852977. Casallas was supported
  by the European Union’s Horizon 2020 research and innovation program under the Marie
  Skłodowska-Curie grant agreement No. 101034413. E. D. Freitas thanks the support
  provided by the National Council for Scientific and Technological Development (CNPq,
  Process number 313210/2022–5). Silva gratefully acknowledges the financial support
  from the National Council for Scientific and Technological Development (CNPq), process
  number 140512/2021–7. P. Lichtig was supported by base funding from the National
  Commission for Atomic Energy (CNEA, Arg.) and by NSF NCAR. R.Y. Ynoue thanks the
  support provided by the National Council for Scientific and Technological Development
  (CNPq, Process number 406728/2022–4). M. A. Franco thanks the support provided by
  the National Council for Scientific and Technological Development (CNPq, Process
  number 407752/2023–4). G. M. Pereira thanks the support by the Fundação de Amparo
  à Pesquisa do Estado de São Paulo (FAPESP; Process numbers 2018/07848–9, 2016/18438–0,
  and 2019/01316–80) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
  (CAPES; Process number 88887.103225/2025–00). M.F. Andrade thanks the support by
  FAPESP (Process number 2016/18438–0) and CNPQ (Klimapolis INCT).
article_number: 5c08400
article_processing_charge: No
article_type: original
author:
- first_name: Sergio
  full_name: Ibarra-Espinosa, Sergio
  last_name: Ibarra-Espinosa
- first_name: Edmilson
  full_name: Dias de Freitas, Edmilson
  last_name: Dias de Freitas
- first_name: Benjamin
  full_name: Gaubert, Benjamin
  last_name: Gaubert
- first_name: Pablo
  full_name: Lichtig, Pablo
  last_name: Lichtig
- first_name: Karl
  full_name: Ropkins, Karl
  last_name: Ropkins
- first_name: Iara
  full_name: da Silva, Iara
  last_name: da Silva
- first_name: Guilherme
  full_name: Martins Pereira, Guilherme
  last_name: Martins Pereira
- first_name: Daniel
  full_name: Schuch, Daniel
  last_name: Schuch
- first_name: Janaina
  full_name: Nascimento, Janaina
  last_name: Nascimento
- first_name: Leonardo
  full_name: Hoinaski, Leonardo
  last_name: Hoinaski
- first_name: Leila Droprinchinski
  full_name: Martins, Leila Droprinchinski
  last_name: Martins
- first_name: Mario
  full_name: Gavidia-Calderón, Mario
  last_name: Gavidia-Calderón
- first_name: Angel
  full_name: Vara-Vela, Angel
  last_name: Vara-Vela
- first_name: Taciana
  full_name: Toledo de Almeida Albuquerque, Taciana
  last_name: Toledo de Almeida Albuquerque
- first_name: Rita Yuri
  full_name: Ynoue, Rita Yuri
  last_name: Ynoue
- first_name: Sebastian
  full_name: Diez, Sebastian
  last_name: Diez
- first_name: Zamir
  full_name: Mera, Zamir
  last_name: Mera
- first_name: Alejandro
  full_name: Casallas Garcia, Alejandro
  id: 92081129-2d75-11ef-a48d-b04dd7a2385a
  last_name: Casallas Garcia
  orcid: 0000-0002-1988-5035
- first_name: Fidel
  full_name: Vallejo, Fidel
  last_name: Vallejo
- first_name: Valeria
  full_name: Diaz, Valeria
  last_name: Diaz
- first_name: Rizzieri
  full_name: Pedruzzi, Rizzieri
  last_name: Pedruzzi
- first_name: Rosana
  full_name: Abrutzky, Rosana
  last_name: Abrutzky
- first_name: Marco A.
  full_name: Franco, Marco A.
  last_name: Franco
- first_name: Nicolas
  full_name: Huneeus, Nicolas
  last_name: Huneeus
- first_name: Hector
  full_name: Jorquera, Hector
  last_name: Jorquera
- first_name: Luis Carlos
  full_name: Belalcázar-Cerón, Luis Carlos
  last_name: Belalcázar-Cerón
- first_name: Néstor Y.
  full_name: Rojas, Néstor Y.
  last_name: Rojas
- first_name: Maria
  full_name: de Fatima Andrade, Maria
  last_name: de Fatima Andrade
- first_name: Louisa
  full_name: Emmons, Louisa
  last_name: Emmons
- first_name: Guy
  full_name: Brasseur, Guy
  last_name: Brasseur
citation:
  ama: 'Ibarra-Espinosa S, Dias de Freitas E, Gaubert B, et al. A century of vehicular
    emissions in Brazil: Unveiling the impacts of unique fuel mix on air quality.
    <i>Environmental Science &#38;amp; Technology</i>. 2026. doi:<a href="https://doi.org/10.1021/acs.est.5c08400">10.1021/acs.est.5c08400</a>'
  apa: 'Ibarra-Espinosa, S., Dias de Freitas, E., Gaubert, B., Lichtig, P., Ropkins,
    K., da Silva, I., … Brasseur, G. (2026). A century of vehicular emissions in Brazil:
    Unveiling the impacts of unique fuel mix on air quality. <i>Environmental Science
    &#38;amp; Technology</i>. American Chemical Society. <a href="https://doi.org/10.1021/acs.est.5c08400">https://doi.org/10.1021/acs.est.5c08400</a>'
  chicago: 'Ibarra-Espinosa, Sergio, Edmilson Dias de Freitas, Benjamin Gaubert, Pablo
    Lichtig, Karl Ropkins, Iara da Silva, Guilherme Martins Pereira, et al. “A Century
    of Vehicular Emissions in Brazil: Unveiling the Impacts of Unique Fuel Mix on
    Air Quality.” <i>Environmental Science &#38;amp; Technology</i>. American Chemical
    Society, 2026. <a href="https://doi.org/10.1021/acs.est.5c08400">https://doi.org/10.1021/acs.est.5c08400</a>.'
  ieee: 'S. Ibarra-Espinosa <i>et al.</i>, “A century of vehicular emissions in Brazil:
    Unveiling the impacts of unique fuel mix on air quality,” <i>Environmental Science
    &#38;amp; Technology</i>. American Chemical Society, 2026.'
  ista: 'Ibarra-Espinosa S, Dias de Freitas E, Gaubert B, Lichtig P, Ropkins K, da
    Silva I, Martins Pereira G, Schuch D, Nascimento J, Hoinaski L, Martins LD, Gavidia-Calderón
    M, Vara-Vela A, Toledo de Almeida Albuquerque T, Ynoue RY, Diez S, Mera Z, Casallas
    Garcia A, Vallejo F, Diaz V, Pedruzzi R, Abrutzky R, Franco MA, Huneeus N, Jorquera
    H, Belalcázar-Cerón LC, Rojas NY, de Fatima Andrade M, Emmons L, Brasseur G. 2026.
    A century of vehicular emissions in Brazil: Unveiling the impacts of unique fuel
    mix on air quality. Environmental Science &#38;amp; Technology., 5c08400.'
  mla: 'Ibarra-Espinosa, Sergio, et al. “A Century of Vehicular Emissions in Brazil:
    Unveiling the Impacts of Unique Fuel Mix on Air Quality.” <i>Environmental Science
    &#38;amp; Technology</i>, 5c08400, American Chemical Society, 2026, doi:<a href="https://doi.org/10.1021/acs.est.5c08400">10.1021/acs.est.5c08400</a>.'
  short: S. Ibarra-Espinosa, E. Dias de Freitas, B. Gaubert, P. Lichtig, K. Ropkins,
    I. da Silva, G. Martins Pereira, D. Schuch, J. Nascimento, L. Hoinaski, L.D. Martins,
    M. Gavidia-Calderón, A. Vara-Vela, T. Toledo de Almeida Albuquerque, R.Y. Ynoue,
    S. Diez, Z. Mera, A. Casallas Garcia, F. Vallejo, V. Diaz, R. Pedruzzi, R. Abrutzky,
    M.A. Franco, N. Huneeus, H. Jorquera, L.C. Belalcázar-Cerón, N.Y. Rojas, M. de
    Fatima Andrade, L. Emmons, G. Brasseur, Environmental Science &#38;amp; Technology
    (2026).
date_created: 2026-02-09T06:54:10Z
date_published: 2026-02-04T00:00:00Z
date_updated: 2026-02-16T10:33:07Z
day: '04'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1021/acs.est.5c08400
ec_funded: 1
external_id:
  pmid:
  - '41636708'
has_accepted_license: '1'
language:
- iso: eng
month: '02'
oa_version: None
pmid: 1
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
publication: Environmental Science &amp; Technology
publication_identifier:
  eissn:
  - 1520-5851
  issn:
  - 0013-936X
publication_status: epub_ahead
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'A century of vehicular emissions in Brazil: Unveiling the impacts of unique
  fuel mix on air quality'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21212'
abstract:
- lang: eng
  text: "Malignant glioma is incurable. Using a mouse genetic mosaic system to generate
    sporadic Trp53,Nf1-null OPCs, we previously identified oligodendrocyte precursor
    cell (OPC) as a cell-of-origin of glioma. Here, we report that pre-malignant Trp53,Nf1-null
    OPCs outcompete wildtype counterparts during their expansion. Blocking competition
    by mutating/strengthening wildtype OPCs impeded both pre-malignant progression
    and malignant expansion of glioma.\r\n\r\n“In-tissue” phosphoproteomic profiling
    revealed an enrichment of phosphopeptides related to RNA splicing and protein
    translation at the peak of cell competition, suggesting that competitiveness may
    stem from unique protein species. Among candidates was mTORC1, whose pharmacological
    inhibition or genetic disruption resulted in a loss of competitiveness in our
    mouse model. Finally, analysis of patient biopsies and interrogating the role
    of individual gliomagenic mutations in OPC competition supported its relevance
    in human gliomas. Together, these findings identified the driving role of competitive
    interactions among OPCs in gliomagenesis, and suggest unconventional therapeutic
    strategies to target this process."
acknowledgement: "We thank Dr. Wenjie Liu for providing critical feedback on the manuscript.
  We also thank Dr.\r\nPat Pramoonjago at the Biorepository and Tissue Research Facility,
  and Hope Davis at the\r\nvivarium for their assistance on the project. These Core
  Facilities are supported by UVA Cancer\r\nCenter grant #P30-CA044579. We are grateful
  to Dr. Jonathan A. Epstein for providing the\r\nNf1GRD/+ mouse strain (https://pubmed.ncbi.nlm.nih.gov/26460546/).
  This work was partly\r\nsupported by the National Institute of Neurological Diseases
  and Stroke R21 NS125479-01A1\r\n(H.Z.), American Cancer Society Institutional Research
  Grant to the University of Virginia\r\n(Y.J.), the National Natural Science Foundation
  of China #82072787 (M.Y.), the National\r\nCancer Institute U54 CA238114 (F.W.),
  U01 CA284193 (K.M.N.), and U54 CA274499 (K.A.J.,\r\nM.F-S.), the National institute
  of General Medical Sciences R35 GM133404 (M.F-S.), the Dr.\r\nMiriam and Sheldon
  G. Adelson Medical Research Foundation (H.I.K., S.A.G.), the National\r\nCenter
  for Advancing Translational Sciences KL2TR001882 (K.S.P.), Tower Cancer Career Development
  Grant (K.S.P.), McKnight Neurobiology of Brain Disorders Grant (K.S.P.). The\r\ncontent
  is solely the responsibility of the authors and does not necessarily represent the
  official\r\nviews of the National Institutes of Health. Illustrations in this manuscript
  were created with\r\nBioRender (BioRender.com)."
article_processing_charge: No
author:
- first_name: Ying
  full_name: Jiang, Ying
  last_name: Jiang
- first_name: Ryuhjin
  full_name: Ahn, Ryuhjin
  last_name: Ahn
- first_name: Arthur
  full_name: Huang, Arthur
  last_name: Huang
- first_name: Phillippe P.
  full_name: Gonzalez, Phillippe P.
  last_name: Gonzalez
- first_name: Jungeun
  full_name: Kim, Jungeun
  last_name: Kim
- first_name: Guoxin
  full_name: Zhang, Guoxin
  last_name: Zhang
- first_name: Zihao
  full_name: Liu, Zihao
  last_name: Liu
- first_name: Zhenqiang
  full_name: He, Zhenqiang
  last_name: He
- first_name: Lindsey
  full_name: Dudley, Lindsey
  last_name: Dudley
- first_name: Kunal S.
  full_name: Patel, Kunal S.
  last_name: Patel
- first_name: Godfrey A.
  full_name: Dzhivhuho, Godfrey A.
  last_name: Dzhivhuho
- first_name: Sam
  full_name: Crowl, Sam
  last_name: Crowl
- first_name: Piotr
  full_name: Przanowski, Piotr
  last_name: Przanowski
- first_name: Luisa Quesada
  full_name: Camacho, Luisa Quesada
  last_name: Camacho
- first_name: Sijie
  full_name: Hao, Sijie
  last_name: Hao
- first_name: Jianhao
  full_name: Zeng, Jianhao
  last_name: Zeng
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: Mohammad
  full_name: Fallahi-Sichani, Mohammad
  last_name: Fallahi-Sichani
- first_name: Kevin A.
  full_name: Janes, Kevin A.
  last_name: Janes
- first_name: Kristen M.
  full_name: Naegle, Kristen M.
  last_name: Naegle
- first_name: Marie-Louise
  full_name: Hammarskjold, Marie-Louise
  last_name: Hammarskjold
- first_name: Steven A.
  full_name: Goldman, Steven A.
  last_name: Goldman
- first_name: Harley I.
  full_name: Kornblum, Harley I.
  last_name: Kornblum
- first_name: Maojin
  full_name: Yao, Maojin
  last_name: Yao
- first_name: Forest
  full_name: White, Forest
  last_name: White
- first_name: Hui
  full_name: Zong, Hui
  last_name: Zong
citation:
  ama: Jiang Y, Ahn R, Huang A, et al. Critical role of cell competition in gliomagenesis.
    <i>bioRxiv</i>. 2026. doi:<a href="https://doi.org/10.64898/2026.01.15.699808">10.64898/2026.01.15.699808</a>
  apa: Jiang, Y., Ahn, R., Huang, A., Gonzalez, P. P., Kim, J., Zhang, G., … Zong,
    H. (2026). Critical role of cell competition in gliomagenesis. <i>bioRxiv</i>.
    <a href="https://doi.org/10.64898/2026.01.15.699808">https://doi.org/10.64898/2026.01.15.699808</a>
  chicago: Jiang, Ying, Ryuhjin Ahn, Arthur Huang, Phillippe P. Gonzalez, Jungeun
    Kim, Guoxin Zhang, Zihao Liu, et al. “Critical Role of Cell Competition in Gliomagenesis.”
    <i>BioRxiv</i>, 2026. <a href="https://doi.org/10.64898/2026.01.15.699808">https://doi.org/10.64898/2026.01.15.699808</a>.
  ieee: Y. Jiang <i>et al.</i>, “Critical role of cell competition in gliomagenesis,”
    <i>bioRxiv</i>. 2026.
  ista: Jiang Y, Ahn R, Huang A, Gonzalez PP, Kim J, Zhang G, Liu Z, He Z, Dudley
    L, Patel KS, Dzhivhuho GA, Crowl S, Przanowski P, Camacho LQ, Hao S, Zeng J, Hippenmeyer
    S, Fallahi-Sichani M, Janes KA, Naegle KM, Hammarskjold M-L, Goldman SA, Kornblum
    HI, Yao M, White F, Zong H. 2026. Critical role of cell competition in gliomagenesis.
    bioRxiv, <a href="https://doi.org/10.64898/2026.01.15.699808">10.64898/2026.01.15.699808</a>.
  mla: Jiang, Ying, et al. “Critical Role of Cell Competition in Gliomagenesis.” <i>BioRxiv</i>,
    2026, doi:<a href="https://doi.org/10.64898/2026.01.15.699808">10.64898/2026.01.15.699808</a>.
  short: Y. Jiang, R. Ahn, A. Huang, P.P. Gonzalez, J. Kim, G. Zhang, Z. Liu, Z. He,
    L. Dudley, K.S. Patel, G.A. Dzhivhuho, S. Crowl, P. Przanowski, L.Q. Camacho,
    S. Hao, J. Zeng, S. Hippenmeyer, M. Fallahi-Sichani, K.A. Janes, K.M. Naegle,
    M.-L. Hammarskjold, S.A. Goldman, H.I. Kornblum, M. Yao, F. White, H. Zong, BioRxiv
    (2026).
date_created: 2026-02-10T12:55:55Z
date_published: 2026-01-16T00:00:00Z
date_updated: 2026-02-16T10:12:42Z
day: '16'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.64898/2026.01.15.699808
has_accepted_license: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
main_file_link:
- open_access: '1'
  url: https://doi.org/10.64898/2026.01.15.699808
month: '01'
oa: 1
oa_version: Preprint
publication: bioRxiv
publication_status: published
status: public
title: Critical role of cell competition in gliomagenesis
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21217'
abstract:
- lang: eng
  text: This study investigates the mechanisms driving clustered convection and the
    breakdown of the Intertropical Convergence Zone (ITCZ) over the Western Pacific
    Warm Pool using high‐resolution cloud‐resolving simulations and machine‐learning
    sensitivity experiments. Results show that ITCZ breakdown episodes, marked by
    spatially homogeneous convection and weakened meridional moisture gradients, are
    triggered primarily by anomalous moisture advection linked to the equatorial Rossby‐wave
    activity. While large‐scale moisture advection regulates the background convective
    state strongly, it is the surface and low‐level meridional winds that dominate
    transitions between clustered and random convection. Simulations demonstrate that
    moisture alone can sustain convective clustering, but breakdown episodes are more
    persistent and widespread when coupled with southerly meridional advection. These
    findings confirm that wave‐driven advection acts as a regulatory mechanism, periodically
    disrupting convective clustering and reshaping the meridional moisture gradient.
    This modulation of organization by wave‐induced breakdown events is critical for
    understanding tropical convection variability and its implications for the climate
    system.
acknowledgement: This article is based on chapter 5 of the PhD thesis of A. Casallas.
  The authors thank Graziano Giuliani for discussions on the boundary-condition experiments.
  A. Casallas was supported by a PhD fellowship awarded by the Abdus Salam International
  Centre for Theoretical Physics. A. Casallas also acknowledges support by the European
  Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie
  grant agreement No 101034413. C. Muller acknowledges funding from the European Research
  Council (ERC) under the European Union's Horizon 2020 research and innovation program
  (Project CLUSTER, Grant Agreement No. 805041). The authors gratefully acknowledge
  Daniel Hernández-Deckers, Lokahith Agasthya, Chris Holloway, and Paolina Cerlini
  for their valuable feedback and insightful discussions. They are especially thankful
  to Bety Pechacova for suggesting the use of SHAP to complement their analysis. They
  also thank the two anonymous reviewers for their constructive comments, which improved
  the quality and clarity of the article significantly. Open Access funding provided
  by Institute of Science and Technology Austria/KEMÖ.
article_number: e70131
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Alejandro
  full_name: Casallas Garcia, Alejandro
  id: 92081129-2d75-11ef-a48d-b04dd7a2385a
  last_name: Casallas Garcia
  orcid: 0000-0002-1988-5035
- first_name: Adrian
  full_name: Mark Tompkins, Adrian
  last_name: Mark Tompkins
- first_name: Caroline J
  full_name: Muller, Caroline J
  id: f978ccb0-3f7f-11eb-b193-b0e2bd13182b
  last_name: Muller
  orcid: 0000-0001-5836-5350
citation:
  ama: Casallas Garcia A, Mark Tompkins A, Muller CJ. Moisture and wind effects of
    Rossby waves on Western Pacific Intertropical Convergence Zone breakdown events.
    <i>Quarterly Journal of the Royal Meteorological Society</i>. 2026. doi:<a href="https://doi.org/10.1002/qj.70131">10.1002/qj.70131</a>
  apa: Casallas Garcia, A., Mark Tompkins, A., &#38; Muller, C. J. (2026). Moisture
    and wind effects of Rossby waves on Western Pacific Intertropical Convergence
    Zone breakdown events. <i>Quarterly Journal of the Royal Meteorological Society</i>.
    Wiley. <a href="https://doi.org/10.1002/qj.70131">https://doi.org/10.1002/qj.70131</a>
  chicago: Casallas Garcia, Alejandro, Adrian Mark Tompkins, and Caroline J Muller.
    “Moisture and Wind Effects of Rossby Waves on Western Pacific Intertropical Convergence
    Zone Breakdown Events.” <i>Quarterly Journal of the Royal Meteorological Society</i>.
    Wiley, 2026. <a href="https://doi.org/10.1002/qj.70131">https://doi.org/10.1002/qj.70131</a>.
  ieee: A. Casallas Garcia, A. Mark Tompkins, and C. J. Muller, “Moisture and wind
    effects of Rossby waves on Western Pacific Intertropical Convergence Zone breakdown
    events,” <i>Quarterly Journal of the Royal Meteorological Society</i>. Wiley,
    2026.
  ista: Casallas Garcia A, Mark Tompkins A, Muller CJ. 2026. Moisture and wind effects
    of Rossby waves on Western Pacific Intertropical Convergence Zone breakdown events.
    Quarterly Journal of the Royal Meteorological Society., e70131.
  mla: Casallas Garcia, Alejandro, et al. “Moisture and Wind Effects of Rossby Waves
    on Western Pacific Intertropical Convergence Zone Breakdown Events.” <i>Quarterly
    Journal of the Royal Meteorological Society</i>, e70131, Wiley, 2026, doi:<a href="https://doi.org/10.1002/qj.70131">10.1002/qj.70131</a>.
  short: A. Casallas Garcia, A. Mark Tompkins, C.J. Muller, Quarterly Journal of the
    Royal Meteorological Society (2026).
corr_author: '1'
date_created: 2026-02-12T10:13:02Z
date_published: 2026-02-12T00:00:00Z
date_updated: 2026-02-16T10:19:52Z
day: '12'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1002/qj.70131
ec_funded: 1
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1002/qj.70131
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
- _id: 629205d8-2b32-11ec-9570-e1356ff73576
  call_identifier: H2020
  grant_number: '805041'
  name: Organization of CLoUdS, and implications of Tropical  cyclones and for the
    Energetics of the tropics, in current and waRming climate
publication: Quarterly Journal of the Royal Meteorological Society
publication_identifier:
  eissn:
  - 1477-870X
  issn:
  - 0035-9009
publication_status: epub_ahead
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Moisture and wind effects of Rossby waves on Western Pacific Intertropical
  Convergence Zone breakdown events
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21230'
abstract:
- lang: eng
  text: Asteroseismology is the study of the interior physics and structure of stars
    using their pulsations. It is applicable to stars across the Hertzsprung–Russell
    (HR) diagram and a powerful technique not only to measure masses, radii, and ages
    but also directly constrain interior rotation, chemical mixing, and magnetism.
    This is because a star's self-excited pulsation modes are sensitive to its structure.
    Asteroseismology generally requires long-duration and high-precision time-series
    data. The method of forward asteroseismic modeling, which is the statistical comparison
    of observed pulsation mode frequencies to theoretically predicted pulsation frequencies
    calculated from a grid of models, provides precise constraints for calibrating
    various transport phenomena. In this introduction to asteroseismology, we provide
    an overview of its principles, and the typical data sets and methodologies used
    to constrain stellar interiors. Finally, we present key highlights of asteroseismic
    results from across the HR diagram, and conclude with ongoing challenges and future
    prospects for this ever-expanding field within stellar astrophysics.
article_processing_charge: No
arxiv: 1
author:
- first_name: Dominic M.
  full_name: Bowman, Dominic M.
  last_name: Bowman
- first_name: Lisa Annabelle
  full_name: Bugnet, Lisa Annabelle
  id: d9edb345-f866-11ec-9b37-d119b5234501
  last_name: Bugnet
  orcid: 0000-0003-0142-4000
citation:
  ama: 'Bowman DM, Bugnet LA. Asteroseismology. In: Mandel I, ed. <i>Encyclopedia
    of Astrophysics</i>. Vol 2. Elsevier; 2026:133-153. doi:<a href="https://doi.org/10.1016/b978-0-443-21439-4.00036-5">10.1016/b978-0-443-21439-4.00036-5</a>'
  apa: Bowman, D. M., &#38; Bugnet, L. A. (2026). Asteroseismology. In I. Mandel (Ed.),
    <i>Encyclopedia of Astrophysics</i> (Vol. 2, pp. 133–153). Elsevier. <a href="https://doi.org/10.1016/b978-0-443-21439-4.00036-5">https://doi.org/10.1016/b978-0-443-21439-4.00036-5</a>
  chicago: Bowman, Dominic M., and Lisa Annabelle Bugnet. “Asteroseismology.” In <i>Encyclopedia
    of Astrophysics</i>, edited by Ilya Mandel, 2:133–53. Elsevier, 2026. <a href="https://doi.org/10.1016/b978-0-443-21439-4.00036-5">https://doi.org/10.1016/b978-0-443-21439-4.00036-5</a>.
  ieee: D. M. Bowman and L. A. Bugnet, “Asteroseismology,” in <i>Encyclopedia of Astrophysics</i>,
    vol. 2, I. Mandel, Ed. Elsevier, 2026, pp. 133–153.
  ista: 'Bowman DM, Bugnet LA. 2026.Asteroseismology. In: Encyclopedia of Astrophysics.
    vol. 2, 133–153.'
  mla: Bowman, Dominic M., and Lisa Annabelle Bugnet. “Asteroseismology.” <i>Encyclopedia
    of Astrophysics</i>, edited by Ilya Mandel, vol. 2, Elsevier, 2026, pp. 133–53,
    doi:<a href="https://doi.org/10.1016/b978-0-443-21439-4.00036-5">10.1016/b978-0-443-21439-4.00036-5</a>.
  short: D.M. Bowman, L.A. Bugnet, in:, I. Mandel (Ed.), Encyclopedia of Astrophysics,
    Elsevier, 2026, pp. 133–153.
date_created: 2026-02-16T10:43:01Z
date_published: 2026-01-01T00:00:00Z
date_updated: 2026-02-17T11:05:20Z
day: '01'
department:
- _id: LiBu
doi: 10.1016/b978-0-443-21439-4.00036-5
editor:
- first_name: Ilya
  full_name: Mandel, Ilya
  last_name: Mandel
external_id:
  arxiv:
  - '2410.01715'
intvolume: '         2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2410.01715
month: '01'
oa: 1
oa_version: Preprint
page: 133-153
publication: Encyclopedia of Astrophysics
publication_identifier:
  isbn:
  - '9780443214400'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Asteroseismology
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21231'
abstract:
- lang: eng
  text: To assess cell migration in complex spatial environments, microfabricated
    chips, such as mazes and pillar forests, are routinely used to impose spatial
    and mechanical constraints, and cell trajectories are followed within these structures
    by advanced imaging techniques. In systems mechanobiology, computational models
    serve as essential tools to uncover how physical geometry influences intracellular
    dynamics; however, decoding such complex behaviors requires advanced inference
    techniques. Here, we integrated experimental observations of dendritic cell migration
    in a geometrically constrained microenvironment into a Cellular Potts model. We
    demonstrated that these spatial constraints modulate the motility dynamics, including
    speed and directional changes. We show that classical summary statistics, such
    as mean squared displacement and turning angle distributions, can resolve key
    mechanistic features but fail to extract richer spatiotemporal patterns, limiting
    accurate parameter inference. To solve this, we applied neural posterior estimation
    with in-the-loop learning of summary features. This learned summary representation
    of the data enables robust and flexible parameter inference, providing a data-driven
    framework for model calibration and advancing quantitative analysis of cell migration
    in structured microenvironments.
acknowledgement: 'This work was supported by the German Federal Ministry of Education
  and Research (BMBF) (EMUNE/031L0293C), the European Union via the ERC grant INTEGRATE,
  grant agreement number 101126146, and under Germany’s Excellence Strategy by the
  Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) (EXC 2047—390685813,
  EXC 2151—390873048, FOR5775 — 533863915, and 524747443), the University of Bonn
  via the Schlegel Professorship of J.H., and the returning experts fellowship of
  the Ministry of Innovation, Science, and Research of North-Rhine-Westphalia (AZ:
  421-8.03.03.02-137069). J.M. is a member of the Nanofabrication Facility and is
  supported by the Institute of Science and Technology Austria. E.K. acknowledges
  the TRA Life and Health (University of Bonn) as part of the Excellence Strategy
  of the federal and state governments. The authors thank Laeschkir Würthner for his
  insightful comments on the implementation of the authors’ model. The views and opinions
  expressed are those of the authors only and do not necessarily reflect those of
  the funding agencies. Parts of Fig. 1 were created using BioRender. Open Access
  funding enabled and organized by Projekt DEAL.'
article_number: '20'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Jonas
  full_name: Arruda, Jonas
  last_name: Arruda
- first_name: Emad
  full_name: Alamoudi, Emad
  last_name: Alamoudi
- first_name: Robert
  full_name: Mueller, Robert
  last_name: Mueller
- first_name: Marc
  full_name: Vaisband, Marc
  last_name: Vaisband
- first_name: Ronja
  full_name: Molkenbur, Ronja
  last_name: Molkenbur
- first_name: Jack
  full_name: Merrin, Jack
  id: 4515C308-F248-11E8-B48F-1D18A9856A87
  last_name: Merrin
  orcid: 0000-0001-5145-4609
- first_name: Eva
  full_name: Kiermaier, Eva
  last_name: Kiermaier
- first_name: Jan
  full_name: Hasenauer, Jan
  last_name: Hasenauer
citation:
  ama: Arruda J, Alamoudi E, Mueller R, et al. Simulation-based inference of cell
    migration dynamics in complex spatial environments. <i>npj Systems Biology and
    Applications</i>. 2026;12. doi:<a href="https://doi.org/10.1038/s41540-026-00648-9">10.1038/s41540-026-00648-9</a>
  apa: Arruda, J., Alamoudi, E., Mueller, R., Vaisband, M., Molkenbur, R., Merrin,
    J., … Hasenauer, J. (2026). Simulation-based inference of cell migration dynamics
    in complex spatial environments. <i>Npj Systems Biology and Applications</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41540-026-00648-9">https://doi.org/10.1038/s41540-026-00648-9</a>
  chicago: Arruda, Jonas, Emad Alamoudi, Robert Mueller, Marc Vaisband, Ronja Molkenbur,
    Jack Merrin, Eva Kiermaier, and Jan Hasenauer. “Simulation-Based Inference of
    Cell Migration Dynamics in Complex Spatial Environments.” <i>Npj Systems Biology
    and Applications</i>. Springer Nature, 2026. <a href="https://doi.org/10.1038/s41540-026-00648-9">https://doi.org/10.1038/s41540-026-00648-9</a>.
  ieee: J. Arruda <i>et al.</i>, “Simulation-based inference of cell migration dynamics
    in complex spatial environments,” <i>npj Systems Biology and Applications</i>,
    vol. 12. Springer Nature, 2026.
  ista: Arruda J, Alamoudi E, Mueller R, Vaisband M, Molkenbur R, Merrin J, Kiermaier
    E, Hasenauer J. 2026. Simulation-based inference of cell migration dynamics in
    complex spatial environments. npj Systems Biology and Applications. 12, 20.
  mla: Arruda, Jonas, et al. “Simulation-Based Inference of Cell Migration Dynamics
    in Complex Spatial Environments.” <i>Npj Systems Biology and Applications</i>,
    vol. 12, 20, Springer Nature, 2026, doi:<a href="https://doi.org/10.1038/s41540-026-00648-9">10.1038/s41540-026-00648-9</a>.
  short: J. Arruda, E. Alamoudi, R. Mueller, M. Vaisband, R. Molkenbur, J. Merrin,
    E. Kiermaier, J. Hasenauer, Npj Systems Biology and Applications 12 (2026).
date_created: 2026-02-16T10:44:31Z
date_published: 2026-02-05T00:00:00Z
date_updated: 2026-02-23T10:10:10Z
day: '05'
ddc:
- '570'
department:
- _id: NanoFab
doi: 10.1038/s41540-026-00648-9
external_id:
  pmid:
  - '41611727'
file:
- access_level: open_access
  checksum: 99b2e6bbaaedf45f22e07751948669f5
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-23T10:09:03Z
  date_updated: 2026-02-23T10:09:03Z
  file_id: '21346'
  file_name: 2026_npjSysBioApp_Arruda.pdf
  file_size: 10217687
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file_date_updated: 2026-02-23T10:09:03Z
has_accepted_license: '1'
intvolume: '        12'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: npj Systems Biology and Applications
publication_identifier:
  eissn:
  - 2056-7189
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Simulation-based inference of cell migration dynamics in complex spatial environments
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21232'
abstract:
- lang: eng
  text: "<jats:title>Abstract</jats:title>\r\n                  <jats:p>In this paper,
    we consider a simple class of stratified spaces – 2-complexes. We present an algorithm
    that learns the abstract structure of an embedded 2-complex from a point cloud
    sampled from it. We use tools and inspiration from computational geometry, algebraic
    topology, and topological data analysis and prove the correctness of the identified
    abstract structure under assumptions on the embedding.</jats:p>"
acknowledgement: The author would like to thank Kate Turner, Chris Williams, Jonathan
  Spreer, Stephan Tillmann, Vanessa Robins, Vigleik Angeltveit, Martin Helmer, and
  James Morgan for very helpful discussions; and thanks Sara Kališnik Hintz and Paul
  Bendich for comments on an earlier version. Additonally, the author would like to
  thank both reviewers for their very insightful and helpful comments, without which
  the paper would be infinitely less coherent than it currently is. Open access funding
  provided by Institute of Science and Technology (IST Austria). The work in this
  paper was supported by an Australian Federal Government Grant, 2019-2022, Stratified
  Space Learning.
article_number: '17'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Yossi
  full_name: Bleile, Yossi
  id: 920a7385-7995-11ef-9bfd-8c434cd8f3c2
  last_name: Bleile
  orcid: 0000-0002-4861-9174
citation:
  ama: 'Bleile Y. Towards stratified space learning: 2-complexes. <i>La Matematica</i>.
    2026;5. doi:<a href="https://doi.org/10.1007/s44007-025-00183-9">10.1007/s44007-025-00183-9</a>'
  apa: 'Bleile, Y. (2026). Towards stratified space learning: 2-complexes. <i>La Matematica</i>.
    Springer Nature. <a href="https://doi.org/10.1007/s44007-025-00183-9">https://doi.org/10.1007/s44007-025-00183-9</a>'
  chicago: 'Bleile, Yossi. “Towards Stratified Space Learning: 2-Complexes.” <i>La
    Matematica</i>. Springer Nature, 2026. <a href="https://doi.org/10.1007/s44007-025-00183-9">https://doi.org/10.1007/s44007-025-00183-9</a>.'
  ieee: 'Y. Bleile, “Towards stratified space learning: 2-complexes,” <i>La Matematica</i>,
    vol. 5. Springer Nature, 2026.'
  ista: 'Bleile Y. 2026. Towards stratified space learning: 2-complexes. La Matematica.
    5, 17.'
  mla: 'Bleile, Yossi. “Towards Stratified Space Learning: 2-Complexes.” <i>La Matematica</i>,
    vol. 5, 17, Springer Nature, 2026, doi:<a href="https://doi.org/10.1007/s44007-025-00183-9">10.1007/s44007-025-00183-9</a>.'
  short: Y. Bleile, La Matematica 5 (2026).
corr_author: '1'
date_created: 2026-02-16T10:44:44Z
date_published: 2026-02-08T00:00:00Z
date_updated: 2026-02-23T10:20:10Z
day: '08'
ddc:
- '510'
department:
- _id: HeEd
doi: 10.1007/s44007-025-00183-9
external_id:
  arxiv:
  - '2305.02724'
file:
- access_level: open_access
  checksum: 6cae2efb47b025af22a8539c606a4e09
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-23T10:18:52Z
  date_updated: 2026-02-23T10:18:52Z
  file_id: '21347'
  file_name: 2026_LaMatematica_Bleile.pdf
  file_size: 15051582
  relation: main_file
  success: 1
file_date_updated: 2026-02-23T10:18:52Z
has_accepted_license: '1'
intvolume: '         5'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
publication: La Matematica
publication_identifier:
  issn:
  - 2730-9657
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Towards stratified space learning: 2-complexes'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21233'
abstract:
- lang: eng
  text: Potential self-perpetuating dieback of the Amazon rain forest has been a topic
    of concern. The concern is that initial deforestation could critically impair
    the forest’s water recycling capacities, further harming the remaining forest
    through reduced annual precipitation. Many studies have focused on annual mean
    precipitation changes, due to its widespread perception as a central control on
    the Amazon rain forest’s stability. However, the impact of deforestation goes
    beyond changes in the annual mean precipitation. Yet, global coarse-resolution
    climate models are not well suited to investigate changes in short-duration and
    localized events due to their coarse resolution. Here, we circumvent these issues
    by analyzing a full-deforestation scenario simulated by a global storm-resolving
    model. We focus on changes in the tail of the hourly distribution of precipitation,
    temperature, and wind. Hourly precipitation becomes more extreme in the absence
    of the forest than in an intact forest, with an increased occurrence of both no
    rain and intense rainfall. These changes are driven by enhanced moisture convergence
    that strengthens vertical velocity. On average, the near-surface temperature rises
    significantly by about 3.84 °C, and the daily minimum temperature after deforestation
    becomes similar to the daily maximum temperature before deforestation. Except
    for wet-bulb temperature, human heat stress indicators shift to more severe levels,
    with implications for health and a significant reduction in work productivity.
    Finally, the mean 10 m wind speed intensifies by a factor of four, with the 99th
    percentile wind speed doubling. To summarize, our findings, while based on an
    idealized case, provide a stark warning of the effects of continuing deforestation
    of the Amazon.
acknowledgement: AY acknowledges funding by the CLICCS centre of excellence subproject
  A3 funded by DFG. We thank the German Climate Computing Center DKRZ for providing
  computing resources and the Integrated Climate Data Center (ICDC), the Center for
  Earth System Research and Sustainability (CEN), University of Hamburg, for supporting
  the IMERG data. In addition, we would like to thank Jana Sillmann for suggesting
  the analysis of heat stress indices and Keno Riechers for providing a thorough internal
  review of the initial manuscript at the Max Planck Institute for Meteorology. Open
  Access funding is enabled and organized by Projekt DEAL. This research has been
  supported by the Deutsche Forschungsgemeinschaft (grant no. CLICCS 390683824 (A3)).
  The article processing charges for this open-access publication were covered by
  the Max Planck Society.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Arim
  full_name: Yoon, Arim
  last_name: Yoon
- first_name: Cathy
  full_name: Hohenegger, Cathy
  last_name: Hohenegger
- first_name: Jiawei
  full_name: Bao, Jiawei
  id: bb9a7399-fefd-11ed-be3c-ae648fd1d160
  last_name: Bao
- first_name: Lukas
  full_name: Brunner, Lukas
  last_name: Brunner
citation:
  ama: Yoon A, Hohenegger C, Bao J, Brunner L. Extreme events in the Amazon after
    deforestation. <i>Earth System Dynamics</i>. 2026;17(1):167-179. doi:<a href="https://doi.org/10.5194/esd-17-167-2026">10.5194/esd-17-167-2026</a>
  apa: Yoon, A., Hohenegger, C., Bao, J., &#38; Brunner, L. (2026). Extreme events
    in the Amazon after deforestation. <i>Earth System Dynamics</i>. Copernicus GmbH.
    <a href="https://doi.org/10.5194/esd-17-167-2026">https://doi.org/10.5194/esd-17-167-2026</a>
  chicago: Yoon, Arim, Cathy Hohenegger, Jiawei Bao, and Lukas Brunner. “Extreme Events
    in the Amazon after Deforestation.” <i>Earth System Dynamics</i>. Copernicus GmbH,
    2026. <a href="https://doi.org/10.5194/esd-17-167-2026">https://doi.org/10.5194/esd-17-167-2026</a>.
  ieee: A. Yoon, C. Hohenegger, J. Bao, and L. Brunner, “Extreme events in the Amazon
    after deforestation,” <i>Earth System Dynamics</i>, vol. 17, no. 1. Copernicus
    GmbH, pp. 167–179, 2026.
  ista: Yoon A, Hohenegger C, Bao J, Brunner L. 2026. Extreme events in the Amazon
    after deforestation. Earth System Dynamics. 17(1), 167–179.
  mla: Yoon, Arim, et al. “Extreme Events in the Amazon after Deforestation.” <i>Earth
    System Dynamics</i>, vol. 17, no. 1, Copernicus GmbH, 2026, pp. 167–79, doi:<a
    href="https://doi.org/10.5194/esd-17-167-2026">10.5194/esd-17-167-2026</a>.
  short: A. Yoon, C. Hohenegger, J. Bao, L. Brunner, Earth System Dynamics 17 (2026)
    167–179.
date_created: 2026-02-16T10:44:58Z
date_published: 2026-02-04T00:00:00Z
date_updated: 2026-02-23T10:28:48Z
day: '04'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.5194/esd-17-167-2026
file:
- access_level: open_access
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  creator: dernst
  date_created: 2026-02-23T10:26:29Z
  date_updated: 2026-02-23T10:26:29Z
  file_id: '21348'
  file_name: 2026_EarthSystDynam_Yoon.pdf
  file_size: 2068229
  relation: main_file
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file_date_updated: 2026-02-23T10:26:29Z
has_accepted_license: '1'
intvolume: '        17'
issue: '1'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 167-179
publication: Earth System Dynamics
publication_identifier:
  eissn:
  - 2190-4987
publication_status: published
publisher: Copernicus GmbH
quality_controlled: '1'
scopus_import: '1'
status: public
title: Extreme events in the Amazon after deforestation
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21234'
abstract:
- lang: eng
  text: In aged humans and mice, hypobranched glycogen aggregates, known as polyglucosan
    bodies (PGBs), accumulate in hippocampal astrocytes. While PGBs are linked to
    cognitive decline in neurological diseases, they remain largely unstudied in the
    context of typical aging. We show that PGBs arise in autophagy-dysregulated astrocytes
    in the aged hippocampus, with substantial variation among 32 inbred BXD mouse
    strains. Genetic mapping through quantitative trait locus analysis identified
    a major locus (Pgb1) that modulates hippocampal PGB burden. Extensive transcriptomic
    and proteomic datasets were produced for the aged hippocampus of the BXD family
    to investigate the mechanism by which the Pgb1 locus modulates PGB burden. We
    identified that Pgb1 contains allelic Smarcal1 and Usp37 variants and influences
    PGB burden through trans-regulation of mRNA and protein expression levels, including
    abundance of glycogen-mobilizing factor PYGB. Furthermore, comprehensive phenome-wide
    association scans, transcriptomic analyses, and direct behavioral testing demonstrated
    that cognition remains intact despite age-related PGB burden. A record of this
    paper’s transparent peer review process is included in the supplemental information.
acknowledgement: We would like to thank the Summer School Systems Genetics of Neural
  Ageing for bringing us together and spurring our international collaboration. We
  would also like to acknowledge the funding for the Summer School 2022 from the e:Med
  Systems Medicine Program of the BMBF (Bundesministerium für Bildung und Forschung;
  German Ministry of Education and Research) to R.W.O. In addition, we would like
  to thank the FLI imaging core facility for their assistance. A.G.-P. is supported
  by Fundación Séneca, Región de Murcia, Spain (21259/FPI/19). D.E.M.d.B. is financed
  by a Rubicon scholarship (452021116) from the Dutch Research Council (NWO). This
  work was also supported by NIH NIA R01AG070913-01 (R.W.W.), R01AG075813-01 (D.G.A.),
  and R01AG075818 (C.K.). We acknowledge the help of Larry Mobraaten (Jackson Laboratory,
  Bar Harbor, MN) with the BXD strains and U. Obermüller for the help with the histology.
  For the purpose of open access, the authors have applied a CC BY public copyright
  license to all author-accepted manuscripts arising from this submission.
article_number: '101488'
article_processing_charge: No
article_type: original
author:
- first_name: Alicia
  full_name: Gómez-Pascual, Alicia
  last_name: Gómez-Pascual
- first_name: Dow M
  full_name: Glikman, Dow M
  id: ab8acda1-91c1-11f0-aad8-f75d3d6424d8
  last_name: Glikman
- first_name: Hui Xin
  full_name: Ng, Hui Xin
  last_name: Ng
- first_name: James E.
  full_name: Tomkins, James E.
  last_name: Tomkins
- first_name: Lu
  full_name: Lu, Lu
  last_name: Lu
- first_name: Ying
  full_name: Xu, Ying
  last_name: Xu
- first_name: David G.
  full_name: Ashbrook, David G.
  last_name: Ashbrook
- first_name: Catherine
  full_name: Kaczorowski, Catherine
  last_name: Kaczorowski
- first_name: Gerd
  full_name: Kempermann, Gerd
  last_name: Kempermann
- first_name: John
  full_name: Killmar, John
  last_name: Killmar
- first_name: Khyobeni
  full_name: Mozhui, Khyobeni
  last_name: Mozhui
- first_name: Oliver
  full_name: Ohlenschläger, Oliver
  last_name: Ohlenschläger
- first_name: Rudolf
  full_name: Aebersold, Rudolf
  last_name: Aebersold
- first_name: Donald K.
  full_name: Ingram, Donald K.
  last_name: Ingram
- first_name: Evan G.
  full_name: Williams, Evan G.
  last_name: Williams
- first_name: Mathias
  full_name: Jucker, Mathias
  last_name: Jucker
- first_name: Rupert W.
  full_name: Overall, Rupert W.
  last_name: Overall
- first_name: Robert W.
  full_name: Williams, Robert W.
  last_name: Williams
- first_name: Dennis E.M.
  full_name: de Bakker, Dennis E.M.
  last_name: de Bakker
citation:
  ama: Gómez-Pascual A, Glikman DM, Ng HX, et al. The Smarcal1-Usp37 locus modulates
    glycogen aggregation in astrocytes of the aged hippocampus. <i>Cell Systems</i>.
    2026;17(2). doi:<a href="https://doi.org/10.1016/j.cels.2025.101488">10.1016/j.cels.2025.101488</a>
  apa: Gómez-Pascual, A., Glikman, D. M., Ng, H. X., Tomkins, J. E., Lu, L., Xu, Y.,
    … de Bakker, D. E. M. (2026). The Smarcal1-Usp37 locus modulates glycogen aggregation
    in astrocytes of the aged hippocampus. <i>Cell Systems</i>. Elsevier. <a href="https://doi.org/10.1016/j.cels.2025.101488">https://doi.org/10.1016/j.cels.2025.101488</a>
  chicago: Gómez-Pascual, Alicia, Dow M Glikman, Hui Xin Ng, James E. Tomkins, Lu
    Lu, Ying Xu, David G. Ashbrook, et al. “The Smarcal1-Usp37 Locus Modulates Glycogen
    Aggregation in Astrocytes of the Aged Hippocampus.” <i>Cell Systems</i>. Elsevier,
    2026. <a href="https://doi.org/10.1016/j.cels.2025.101488">https://doi.org/10.1016/j.cels.2025.101488</a>.
  ieee: A. Gómez-Pascual <i>et al.</i>, “The Smarcal1-Usp37 locus modulates glycogen
    aggregation in astrocytes of the aged hippocampus,” <i>Cell Systems</i>, vol.
    17, no. 2. Elsevier, 2026.
  ista: Gómez-Pascual A, Glikman DM, Ng HX, Tomkins JE, Lu L, Xu Y, Ashbrook DG, Kaczorowski
    C, Kempermann G, Killmar J, Mozhui K, Ohlenschläger O, Aebersold R, Ingram DK,
    Williams EG, Jucker M, Overall RW, Williams RW, de Bakker DEM. 2026. The Smarcal1-Usp37
    locus modulates glycogen aggregation in astrocytes of the aged hippocampus. Cell
    Systems. 17(2), 101488.
  mla: Gómez-Pascual, Alicia, et al. “The Smarcal1-Usp37 Locus Modulates Glycogen
    Aggregation in Astrocytes of the Aged Hippocampus.” <i>Cell Systems</i>, vol.
    17, no. 2, 101488, Elsevier, 2026, doi:<a href="https://doi.org/10.1016/j.cels.2025.101488">10.1016/j.cels.2025.101488</a>.
  short: A. Gómez-Pascual, D.M. Glikman, H.X. Ng, J.E. Tomkins, L. Lu, Y. Xu, D.G.
    Ashbrook, C. Kaczorowski, G. Kempermann, J. Killmar, K. Mozhui, O. Ohlenschläger,
    R. Aebersold, D.K. Ingram, E.G. Williams, M. Jucker, R.W. Overall, R.W. Williams,
    D.E.M. de Bakker, Cell Systems 17 (2026).
date_created: 2026-02-16T10:45:10Z
date_published: 2026-02-18T00:00:00Z
date_updated: 2026-02-23T10:35:01Z
day: '18'
ddc:
- '570'
department:
- _id: GradSch
doi: 10.1016/j.cels.2025.101488
external_id:
  pmid:
  - '41633365'
file:
- access_level: open_access
  checksum: 920e8edfd3b8b42f5bb6f86d4c66c54d
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  date_created: 2026-02-23T10:32:12Z
  date_updated: 2026-02-23T10:32:12Z
  file_id: '21349'
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  file_size: 10606778
  relation: main_file
  success: 1
file_date_updated: 2026-02-23T10:32:12Z
has_accepted_license: '1'
intvolume: '        17'
issue: '2'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: Cell Systems
publication_identifier:
  issn:
  - 2405-4712
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the
  aged hippocampus
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
