---
_id: '10530'
abstract:
- lang: eng
  text: "Cell dispersion from a confined area is fundamental in a number of biological
    processes,\r\nincluding cancer metastasis. To date, a quantitative understanding
    of the interplay of single\r\ncell motility, cell proliferation, and intercellular
    contacts remains elusive. In particular, the role\r\nof E- and N-Cadherin junctions,
    central components of intercellular contacts, is still\r\ncontroversial. Combining
    theoretical modeling with in vitro observations, we investigate the\r\ncollective
    spreading behavior of colonies of human cancer cells (T24). The spreading of these\r\ncolonies
    is driven by stochastic single-cell migration with frequent transient cell-cell
    contacts.\r\nWe find that inhibition of E- and N-Cadherin junctions decreases
    colony spreading and average\r\nspreading velocities, without affecting the strength
    of correlations in spreading velocities of\r\nneighboring cells. Based on a biophysical
    simulation model for cell migration, we show that the\r\nbehavioral changes upon
    disruption of these junctions can be explained by reduced repulsive\r\nexcluded
    volume interactions between cells. This suggests that in cancer cell migration,\r\ncadherin-based
    intercellular contacts sharpen cell boundaries leading to repulsive rather than\r\ncohesive
    interactions between cells, thereby promoting efficient cell spreading during
    collective\r\nmigration.\r\n"
acknowledgement: Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research
  Foundation) - Project-ID 201269156 - SFB 1032 (Projects B8 and B12). D.B.B. is supported
  in part by a DFG fellowship within the Graduate School of Quantitative Biosciences
  Munich (QBM) and by the Joachim Herz Stiftung.
article_processing_charge: No
article_type: original
author:
- first_name: Themistoklis
  full_name: Zisis, Themistoklis
  last_name: Zisis
- first_name: David
  full_name: Brückner, David
  id: e1e86031-6537-11eb-953a-f7ab92be508d
  last_name: Brückner
  orcid: 0000-0001-7205-2975
- first_name: Tom
  full_name: Brandstätter, Tom
  last_name: Brandstätter
- first_name: Wei Xiong
  full_name: Siow, Wei Xiong
  last_name: Siow
- first_name: Joseph
  full_name: d’Alessandro, Joseph
  last_name: d’Alessandro
- first_name: Angelika M.
  full_name: Vollmar, Angelika M.
  last_name: Vollmar
- first_name: Chase P.
  full_name: Broedersz, Chase P.
  last_name: Broedersz
- first_name: Stefan
  full_name: Zahler, Stefan
  last_name: Zahler
citation:
  ama: Zisis T, Brückner D, Brandstätter T, et al. Disentangling cadherin-mediated
    cell-cell interactions in collective cancer cell migration. <i>Biophysical Journal</i>.
    2022;121(1):P44-60. doi:<a href="https://doi.org/10.1016/j.bpj.2021.12.006">10.1016/j.bpj.2021.12.006</a>
  apa: Zisis, T., Brückner, D., Brandstätter, T., Siow, W. X., d’Alessandro, J., Vollmar,
    A. M., … Zahler, S. (2022). Disentangling cadherin-mediated cell-cell interactions
    in collective cancer cell migration. <i>Biophysical Journal</i>. Elsevier. <a
    href="https://doi.org/10.1016/j.bpj.2021.12.006">https://doi.org/10.1016/j.bpj.2021.12.006</a>
  chicago: Zisis, Themistoklis, David Brückner, Tom Brandstätter, Wei Xiong Siow,
    Joseph d’Alessandro, Angelika M. Vollmar, Chase P. Broedersz, and Stefan Zahler.
    “Disentangling Cadherin-Mediated Cell-Cell Interactions in Collective Cancer Cell
    Migration.” <i>Biophysical Journal</i>. Elsevier, 2022. <a href="https://doi.org/10.1016/j.bpj.2021.12.006">https://doi.org/10.1016/j.bpj.2021.12.006</a>.
  ieee: T. Zisis <i>et al.</i>, “Disentangling cadherin-mediated cell-cell interactions
    in collective cancer cell migration,” <i>Biophysical Journal</i>, vol. 121, no.
    1. Elsevier, pp. P44-60, 2022.
  ista: Zisis T, Brückner D, Brandstätter T, Siow WX, d’Alessandro J, Vollmar AM,
    Broedersz CP, Zahler S. 2022. Disentangling cadherin-mediated cell-cell interactions
    in collective cancer cell migration. Biophysical Journal. 121(1), P44-60.
  mla: Zisis, Themistoklis, et al. “Disentangling Cadherin-Mediated Cell-Cell Interactions
    in Collective Cancer Cell Migration.” <i>Biophysical Journal</i>, vol. 121, no.
    1, Elsevier, 2022, pp. P44-60, doi:<a href="https://doi.org/10.1016/j.bpj.2021.12.006">10.1016/j.bpj.2021.12.006</a>.
  short: T. Zisis, D. Brückner, T. Brandstätter, W.X. Siow, J. d’Alessandro, A.M.
    Vollmar, C.P. Broedersz, S. Zahler, Biophysical Journal 121 (2022) P44-60.
date_created: 2021-12-10T09:48:19Z
date_published: 2022-01-04T00:00:00Z
date_updated: 2025-06-11T13:59:29Z
day: '04'
ddc:
- '570'
department:
- _id: EdHa
- _id: GaTk
doi: 10.1016/j.bpj.2021.12.006
external_id:
  isi:
  - '000740815400007'
  pmid:
  - '34890578'
file:
- access_level: open_access
  checksum: 1aa7c3478e0c8256b973b632efd1f6b4
  content_type: application/pdf
  creator: dernst
  date_created: 2022-07-29T10:17:10Z
  date_updated: 2022-07-29T10:17:10Z
  file_id: '11697'
  file_name: 2022_BiophysicalJour_Zisis.pdf
  file_size: 4475504
  relation: main_file
  success: 1
file_date_updated: 2022-07-29T10:17:10Z
has_accepted_license: '1'
intvolume: '       121'
isi: 1
issue: '1'
keyword:
- Biophysics
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '01'
oa: 1
oa_version: Published Version
page: P44-60
pmid: 1
project:
- _id: 9B861AAC-BA93-11EA-9121-9846C619BF3A
  name: NOMIS Fellowship Program
publication: Biophysical Journal
publication_identifier:
  issn:
  - 0006-3495
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Disentangling cadherin-mediated cell-cell interactions in collective cancer
  cell migration
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 121
year: '2022'
...
---
_id: '10537'
abstract:
- lang: eng
  text: We consider the quantum many-body evolution of a homogeneous Fermi gas in
    three dimensions in the coupled semiclassical and mean-field scaling regime. We
    study a class of initial data describing collective particle–hole pair excitations
    on the Fermi ball. Using a rigorous version of approximate bosonization, we prove
    that the many-body evolution can be approximated in Fock space norm by a quasi-free
    bosonic evolution of the collective particle–hole excitations.
acknowledgement: NB was supported by Gruppo Nazionale per la Fisica Matematica (GNFM).
  RS was supported by the European Research Council (ERC) under the European Union’s
  Horizon 2020 research and innovation program (Grant Agreement No. 694227). PTN was
  supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
  under Germany’s Excellence Strategy (EXC-2111-390814868). MP was supported by the
  European Research Council (ERC) under the European Union’s Horizon 2020 research
  and innovation program (ERC StG MaMBoQ, Grant Agreement No. 802901). BS was supported
  by the NCCR SwissMAP, the Swiss National Science Foundation through the Grant “Dynamical
  and energetic properties of Bose-Einstein condensates,” and the European Research
  Council (ERC) under the European Union’s Horizon 2020 research and innovation program
  through the ERC-AdG CLaQS (Grant Agreement No. 834782).
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Niels P
  full_name: Benedikter, Niels P
  id: 3DE6C32A-F248-11E8-B48F-1D18A9856A87
  last_name: Benedikter
  orcid: 0000-0002-1071-6091
- first_name: Phan Thành
  full_name: Nam, Phan Thành
  last_name: Nam
- first_name: Marcello
  full_name: Porta, Marcello
  last_name: Porta
- first_name: Benjamin
  full_name: Schlein, Benjamin
  last_name: Schlein
- first_name: Robert
  full_name: Seiringer, Robert
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
citation:
  ama: Benedikter NP, Nam PT, Porta M, Schlein B, Seiringer R. Bosonization of fermionic
    many-body dynamics. <i>Annales Henri Poincaré</i>. 2022;23(5):1725-1764. doi:<a
    href="https://doi.org/10.1007/s00023-021-01136-y">10.1007/s00023-021-01136-y</a>
  apa: Benedikter, N. P., Nam, P. T., Porta, M., Schlein, B., &#38; Seiringer, R.
    (2022). Bosonization of fermionic many-body dynamics. <i>Annales Henri Poincaré</i>.
    Springer Nature. <a href="https://doi.org/10.1007/s00023-021-01136-y">https://doi.org/10.1007/s00023-021-01136-y</a>
  chicago: Benedikter, Niels P, Phan Thành Nam, Marcello Porta, Benjamin Schlein,
    and Robert Seiringer. “Bosonization of Fermionic Many-Body Dynamics.” <i>Annales
    Henri Poincaré</i>. Springer Nature, 2022. <a href="https://doi.org/10.1007/s00023-021-01136-y">https://doi.org/10.1007/s00023-021-01136-y</a>.
  ieee: N. P. Benedikter, P. T. Nam, M. Porta, B. Schlein, and R. Seiringer, “Bosonization
    of fermionic many-body dynamics,” <i>Annales Henri Poincaré</i>, vol. 23, no.
    5. Springer Nature, pp. 1725–1764, 2022.
  ista: Benedikter NP, Nam PT, Porta M, Schlein B, Seiringer R. 2022. Bosonization
    of fermionic many-body dynamics. Annales Henri Poincaré. 23(5), 1725–1764.
  mla: Benedikter, Niels P., et al. “Bosonization of Fermionic Many-Body Dynamics.”
    <i>Annales Henri Poincaré</i>, vol. 23, no. 5, Springer Nature, 2022, pp. 1725–64,
    doi:<a href="https://doi.org/10.1007/s00023-021-01136-y">10.1007/s00023-021-01136-y</a>.
  short: N.P. Benedikter, P.T. Nam, M. Porta, B. Schlein, R. Seiringer, Annales Henri
    Poincaré 23 (2022) 1725–1764.
date_created: 2021-12-12T23:01:28Z
date_published: 2022-05-01T00:00:00Z
date_updated: 2025-04-14T07:26:53Z
day: '01'
department:
- _id: RoSe
doi: 10.1007/s00023-021-01136-y
ec_funded: 1
external_id:
  arxiv:
  - '2103.08224'
  isi:
  - '000725405700001'
intvolume: '        23'
isi: 1
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2103.08224
month: '05'
oa: 1
oa_version: Preprint
page: 1725-1764
project:
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '694227'
  name: Analysis of quantum many-body systems
publication: Annales Henri Poincaré
publication_identifier:
  issn:
  - 1424-0637
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Bosonization of fermionic many-body dynamics
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2022'
...
---
_id: '10547'
abstract:
- lang: eng
  text: "We establish global-in-time existence results for thermodynamically consistent
    reaction-(cross-)diffusion systems coupled to an equation describing heat transfer.
    Our main interest is to model species-dependent diffusivities,\r\nwhile at the
    same time ensuring thermodynamic consistency. A key difficulty of the non-isothermal
    case lies in the intrinsic presence of cross-diffusion type phenomena like the
    Soret and the Dufour effect: due to the temperature/energy dependence of the thermodynamic
    equilibria, a nonvanishing temperature gradient may drive a concentration flux
    even in a situation with constant concentrations; likewise, a nonvanishing concentration
    gradient may drive a heat flux even in a case of spatially constant temperature.
    We use time discretisation and regularisation techniques and derive a priori estimates
    based on a suitable entropy and the associated entropy production. Renormalised
    solutions are used in cases where non-integrable diffusion fluxes or reaction
    terms appear."
acknowledgement: M.K. gratefully acknowledges the hospitality of WIAS Berlin, where
  a major part of the project was carried out. The research stay of M.K. at WIAS Berlin
  was funded by the Austrian Federal Ministry of Education, Science and Research through
  a research fellowship for graduates of a promotio sub auspiciis. The research of
  A.M. has been partially supported by Deutsche Forschungsgemeinschaft (DFG) through
  the Collaborative Research Center SFB 1114 “Scaling Cascades in Complex Systems”
  (Project no. 235221301), Subproject C05 “Effective models for materials and interfaces
  with multiple scales”. J.F. and A.M. are grateful for the hospitality of the Erwin
  Schrödinger Institute in Vienna, where some ideas for this work have been developed.
  The authors are grateful to two anonymous referees for several helpful comments,
  in particular for the short proof of estimate (2.7).
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Julian L
  full_name: Fischer, Julian L
  id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
  last_name: Fischer
  orcid: 0000-0002-0479-558X
- first_name: Katharina
  full_name: Hopf, Katharina
  last_name: Hopf
- first_name: Michael
  full_name: Kniely, Michael
  id: 2CA2C08C-F248-11E8-B48F-1D18A9856A87
  last_name: Kniely
  orcid: 0000-0001-5645-4333
- first_name: Alexander
  full_name: Mielke, Alexander
  last_name: Mielke
citation:
  ama: Fischer JL, Hopf K, Kniely M, Mielke A. Global existence analysis of energy-reaction-diffusion
    systems. <i>SIAM Journal on Mathematical Analysis</i>. 2022;54(1):220-267. doi:<a
    href="https://doi.org/10.1137/20M1387237">10.1137/20M1387237</a>
  apa: Fischer, J. L., Hopf, K., Kniely, M., &#38; Mielke, A. (2022). Global existence
    analysis of energy-reaction-diffusion systems. <i>SIAM Journal on Mathematical
    Analysis</i>. Society for Industrial and Applied Mathematics. <a href="https://doi.org/10.1137/20M1387237">https://doi.org/10.1137/20M1387237</a>
  chicago: Fischer, Julian L, Katharina Hopf, Michael Kniely, and Alexander Mielke.
    “Global Existence Analysis of Energy-Reaction-Diffusion Systems.” <i>SIAM Journal
    on Mathematical Analysis</i>. Society for Industrial and Applied Mathematics,
    2022. <a href="https://doi.org/10.1137/20M1387237">https://doi.org/10.1137/20M1387237</a>.
  ieee: J. L. Fischer, K. Hopf, M. Kniely, and A. Mielke, “Global existence analysis
    of energy-reaction-diffusion systems,” <i>SIAM Journal on Mathematical Analysis</i>,
    vol. 54, no. 1. Society for Industrial and Applied Mathematics, pp. 220–267, 2022.
  ista: Fischer JL, Hopf K, Kniely M, Mielke A. 2022. Global existence analysis of
    energy-reaction-diffusion systems. SIAM Journal on Mathematical Analysis. 54(1),
    220–267.
  mla: Fischer, Julian L., et al. “Global Existence Analysis of Energy-Reaction-Diffusion
    Systems.” <i>SIAM Journal on Mathematical Analysis</i>, vol. 54, no. 1, Society
    for Industrial and Applied Mathematics, 2022, pp. 220–67, doi:<a href="https://doi.org/10.1137/20M1387237">10.1137/20M1387237</a>.
  short: J.L. Fischer, K. Hopf, M. Kniely, A. Mielke, SIAM Journal on Mathematical
    Analysis 54 (2022) 220–267.
date_created: 2021-12-16T12:08:56Z
date_published: 2022-01-04T00:00:00Z
date_updated: 2023-08-02T13:37:03Z
day: '04'
department:
- _id: JuFi
doi: 10.1137/20M1387237
external_id:
  arxiv:
  - '2012.03792 '
  isi:
  - '000762768000006'
intvolume: '        54'
isi: 1
issue: '1'
keyword:
- Energy-Reaction-Diffusion Systems
- Cross Diffusion
- Global-In-Time Existence of Weak/Renormalised Solutions
- Entropy Method
- Onsager System
- Soret/Dufour Effect
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2012.03792
month: '01'
oa: 1
oa_version: Preprint
page: 220-267
publication: SIAM Journal on Mathematical Analysis
publication_identifier:
  issn:
  - 0036-1410
publication_status: published
publisher: Society for Industrial and Applied Mathematics
quality_controlled: '1'
scopus_import: '1'
status: public
title: Global existence analysis of energy-reaction-diffusion systems
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 54
year: '2022'
...
---
_id: '10548'
abstract:
- lang: eng
  text: "Consider a linear elliptic partial differential equation in divergence form
    with a random coefficient field. The solution operator displays fluctuations around
    its expectation. The recently developed pathwise theory of fluctuations in stochastic
    homogenization reduces the characterization of these fluctuations to those of
    the so-called standard homogenization commutator. In this contribution, we investigate
    the scaling limit of this key quantity: starting\r\nfrom a Gaussian-like coefficient
    field with possibly strong correlations, we establish the convergence of the rescaled
    commutator to a fractional Gaussian field, depending on the decay of correlations
    of the coefficient field, and we\r\ninvestigate the (non)degeneracy of the limit.
    This extends to general dimension $d\\ge1$ previous results so far limited to
    dimension $d=1$, and to the continuum setting with strong correlations recent
    results in the discrete iid case."
acknowledgement: The authors thank Ivan Nourdin and Felix Otto for inspiring discussions.
  The work of MD is financially supported by the CNRS-Momentum program. Financial
  support of AG is acknowledged from the European Research Council under the European
  Community’s Seventh Framework Programme (FP7/2014-2019 Grant Agreement QUANTHOM
  335410).
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Mitia
  full_name: Duerinckx, Mitia
  last_name: Duerinckx
- first_name: Julian L
  full_name: Fischer, Julian L
  id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
  last_name: Fischer
  orcid: 0000-0002-0479-558X
- first_name: Antoine
  full_name: Gloria, Antoine
  last_name: Gloria
citation:
  ama: Duerinckx M, Fischer JL, Gloria A. Scaling limit of the homogenization commutator
    for Gaussian coefficient  fields. <i>Annals of applied probability</i>. 2022;32(2):1179-1209.
    doi:<a href="https://doi.org/10.1214/21-AAP1705">10.1214/21-AAP1705</a>
  apa: Duerinckx, M., Fischer, J. L., &#38; Gloria, A. (2022). Scaling limit of the
    homogenization commutator for Gaussian coefficient  fields. <i>Annals of Applied
    Probability</i>. Institute of Mathematical Statistics. <a href="https://doi.org/10.1214/21-AAP1705">https://doi.org/10.1214/21-AAP1705</a>
  chicago: Duerinckx, Mitia, Julian L Fischer, and Antoine Gloria. “Scaling Limit
    of the Homogenization Commutator for Gaussian Coefficient  Fields.” <i>Annals
    of Applied Probability</i>. Institute of Mathematical Statistics, 2022. <a href="https://doi.org/10.1214/21-AAP1705">https://doi.org/10.1214/21-AAP1705</a>.
  ieee: M. Duerinckx, J. L. Fischer, and A. Gloria, “Scaling limit of the homogenization
    commutator for Gaussian coefficient  fields,” <i>Annals of applied probability</i>,
    vol. 32, no. 2. Institute of Mathematical Statistics, pp. 1179–1209, 2022.
  ista: Duerinckx M, Fischer JL, Gloria A. 2022. Scaling limit of the homogenization
    commutator for Gaussian coefficient  fields. Annals of applied probability. 32(2),
    1179–1209.
  mla: Duerinckx, Mitia, et al. “Scaling Limit of the Homogenization Commutator for
    Gaussian Coefficient  Fields.” <i>Annals of Applied Probability</i>, vol. 32,
    no. 2, Institute of Mathematical Statistics, 2022, pp. 1179–209, doi:<a href="https://doi.org/10.1214/21-AAP1705">10.1214/21-AAP1705</a>.
  short: M. Duerinckx, J.L. Fischer, A. Gloria, Annals of Applied Probability 32 (2022)
    1179–1209.
corr_author: '1'
date_created: 2021-12-16T12:10:16Z
date_published: 2022-04-28T00:00:00Z
date_updated: 2024-10-09T21:01:17Z
day: '28'
department:
- _id: JuFi
doi: 10.1214/21-AAP1705
external_id:
  arxiv:
  - '1910.04088'
  isi:
  - '000791003700011'
intvolume: '        32'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1910.04088
month: '04'
oa: 1
oa_version: Preprint
page: 1179-1209
publication: Annals of applied probability
publication_identifier:
  issn:
  - 1050-5164
publication_status: published
publisher: Institute of Mathematical Statistics
quality_controlled: '1'
scopus_import: '1'
status: public
title: Scaling limit of the homogenization commutator for Gaussian coefficient  fields
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 32
year: '2022'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21078'
abstract:
- lang: eng
  text: The ease with which racemic mixtures crystallize compared with the equivalent
    chiral systems is routinely taken advantage of to produce crystals of small molecules.
    However, biological macromolecules such as DNA and proteins are naturally chiral,
    and thus the limited range of chiral space groups available hampers the crystallization
    of such molecules. Inspiring work over the past 15 years has shown that racemic
    mixtures of proteins, which were made possible by impressive advances in protein
    chemical synthesis, can indeed improve the success rate of protein crystallization
    experiments. More recently, the racemic crystallization approach was extended
    to include nucleic acids as a possible aid in the determination of enantiopure
    DNA crystal structures. Here, findings are reported that suggest that the benefits
    may extend beyond this. Two racemic crystal structures of the DNA sequence d(CCCGGG)
    are described which were found to fold into A-form DNA. This form differs from
    the Z-form DNA conformation adopted by the chiral equivalent in the solid state,
    suggesting that the use of racemates may also favour the emergence of new conformations.
    Importantly, the racemic mixture forms interactions in the solid state that differ
    from the chiral equivalent (including the formation of racemic pseudo-helices),
    suggesting that the use of racemic DNA mixtures could provide new possibilities
    for the design of precise self-assembled nanomaterials and nanostructures.
article_processing_charge: No
article_type: original
author:
- first_name: Pradeep K
  full_name: Mandal, Pradeep K
  id: 6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
  last_name: Mandal
  orcid: 0000-0001-5996-956X
- first_name: Gavin W.
  full_name: Collie, Gavin W.
  last_name: Collie
- first_name: Brice
  full_name: Kauffmann, Brice
  last_name: Kauffmann
- first_name: Ivan
  full_name: Huc, Ivan
  last_name: Huc
citation:
  ama: Mandal PK, Collie GW, Kauffmann B, Huc I. Racemic crystal structures of A-DNA
    duplexes. <i>Acta Crystallographica Section D Structural Biology</i>. 2022;78(6):709-715.
    doi:<a href="https://doi.org/10.1107/s2059798322003928">10.1107/s2059798322003928</a>
  apa: Mandal, P. K., Collie, G. W., Kauffmann, B., &#38; Huc, I. (2022). Racemic
    crystal structures of A-DNA duplexes. <i>Acta Crystallographica Section D Structural
    Biology</i>. International Union of Crystallography. <a href="https://doi.org/10.1107/s2059798322003928">https://doi.org/10.1107/s2059798322003928</a>
  chicago: Mandal, Pradeep K, Gavin W. Collie, Brice Kauffmann, and Ivan Huc. “Racemic
    Crystal Structures of A-DNA Duplexes.” <i>Acta Crystallographica Section D Structural
    Biology</i>. International Union of Crystallography, 2022. <a href="https://doi.org/10.1107/s2059798322003928">https://doi.org/10.1107/s2059798322003928</a>.
  ieee: P. K. Mandal, G. W. Collie, B. Kauffmann, and I. Huc, “Racemic crystal structures
    of A-DNA duplexes,” <i>Acta Crystallographica Section D Structural Biology</i>,
    vol. 78, no. 6. International Union of Crystallography, pp. 709–715, 2022.
  ista: Mandal PK, Collie GW, Kauffmann B, Huc I. 2022. Racemic crystal structures
    of A-DNA duplexes. Acta Crystallographica Section D Structural Biology. 78(6),
    709–715.
  mla: Mandal, Pradeep K., et al. “Racemic Crystal Structures of A-DNA Duplexes.”
    <i>Acta Crystallographica Section D Structural Biology</i>, vol. 78, no. 6, International
    Union of Crystallography, 2022, pp. 709–15, doi:<a href="https://doi.org/10.1107/s2059798322003928">10.1107/s2059798322003928</a>.
  short: P.K. Mandal, G.W. Collie, B. Kauffmann, I. Huc, Acta Crystallographica Section
    D Structural Biology 78 (2022) 709–715.
date_created: 2026-01-29T14:59:50Z
date_published: 2022-06-01T00:00:00Z
date_updated: 2026-02-24T07:08:58Z
day: '01'
ddc:
- '570'
doi: 10.1107/s2059798322003928
extern: '1'
external_id:
  pmid:
  - '35647918'
has_accepted_license: '1'
intvolume: '        78'
issue: '6'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1107/S2059798322003928
month: '06'
oa: 1
oa_version: Published Version
page: 709-715
pmid: 1
publication: Acta Crystallographica Section D Structural Biology
publication_identifier:
  eissn:
  - 2059-7983
publication_status: published
publisher: International Union of Crystallography
quality_controlled: '1'
status: public
title: Racemic crystal structures of A-DNA duplexes
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 78
year: '2022'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21079'
abstract:
- lang: eng
  text: '<jats:title>Abstract</jats:title><jats:p>A series of aromatic oligoamide
    foldamer sequences containing different proportions of three δ‐amino acids derived
    from quinoline, pyridine, and benzene and possessing varying flexibility, for
    example due to methylene bridges, were synthesized. Crystallographic structures
    of two key sequences and <jats:sup>1</jats:sup>H NMR data in water concur to show
    that a canonical aromatic helix fold prevails in almost all cases and that helix
    stability critically depends on the ratio between rigid and flexible units. Notwithstanding
    subtle variations of curvature, i. e. the numbers of units per turn, the aromatic
    δ‐peptide helix is therefore shown to be general and tolerant of a great number
    of sp<jats:sup>3</jats:sup> centers. We also demonstrate canonical helical folding
    upon alternating two monomers that do not promote folding when taken separately:
    folding occurs with two methylenes between every other unit, not with one methylene
    between every unit. These findings highlight that a fine‐tuning of helix handedness
    inversion kinetics, curvature, and side chain positioning in aromatic δ‐peptidic
    foldamers can be realized by systematically combining different yet compatible
    δ‐amino acids.</jats:p>'
article_number: e202200538
article_processing_charge: No
article_type: original
author:
- first_name: Daniel
  full_name: Bindl, Daniel
  last_name: Bindl
- first_name: Pradeep K
  full_name: Mandal, Pradeep K
  id: 6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
  last_name: Mandal
  orcid: 0000-0001-5996-956X
- first_name: Ivan
  full_name: Huc, Ivan
  last_name: Huc
citation:
  ama: Bindl D, Mandal PK, Huc I. Generalizing the aromatic δ‐amino acid foldamer
    helix. <i>Chemistry – A European Journal</i>. 2022;28(31). doi:<a href="https://doi.org/10.1002/chem.202200538">10.1002/chem.202200538</a>
  apa: Bindl, D., Mandal, P. K., &#38; Huc, I. (2022). Generalizing the aromatic δ‐amino
    acid foldamer helix. <i>Chemistry – A European Journal</i>. Wiley. <a href="https://doi.org/10.1002/chem.202200538">https://doi.org/10.1002/chem.202200538</a>
  chicago: Bindl, Daniel, Pradeep K Mandal, and Ivan Huc. “Generalizing the Aromatic
    Δ‐amino Acid Foldamer Helix.” <i>Chemistry – A European Journal</i>. Wiley, 2022.
    <a href="https://doi.org/10.1002/chem.202200538">https://doi.org/10.1002/chem.202200538</a>.
  ieee: D. Bindl, P. K. Mandal, and I. Huc, “Generalizing the aromatic δ‐amino acid
    foldamer helix,” <i>Chemistry – A European Journal</i>, vol. 28, no. 31. Wiley,
    2022.
  ista: Bindl D, Mandal PK, Huc I. 2022. Generalizing the aromatic δ‐amino acid foldamer
    helix. Chemistry – A European Journal. 28(31), e202200538.
  mla: Bindl, Daniel, et al. “Generalizing the Aromatic Δ‐amino Acid Foldamer Helix.”
    <i>Chemistry – A European Journal</i>, vol. 28, no. 31, e202200538, Wiley, 2022,
    doi:<a href="https://doi.org/10.1002/chem.202200538">10.1002/chem.202200538</a>.
  short: D. Bindl, P.K. Mandal, I. Huc, Chemistry – A European Journal 28 (2022).
date_created: 2026-01-29T15:05:40Z
date_published: 2022-06-01T00:00:00Z
date_updated: 2026-02-20T07:04:18Z
day: '01'
ddc:
- '540'
doi: 10.1002/chem.202200538
extern: '1'
external_id:
  pmid:
  - '35332956'
has_accepted_license: '1'
intvolume: '        28'
issue: '31'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1002/chem.202200538
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
publication: Chemistry – A European Journal
publication_identifier:
  eissn:
  - 1521-3765
  issn:
  - 0947-6539
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Generalizing the aromatic δ‐amino acid foldamer helix
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 28
year: '2022'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21080'
abstract:
- lang: eng
  text: Tight binding was observed between the C‐terminal cross section of aromatic
    oligoamide helices in aqueous solution, leading to the formation of discrete head‐to‐head
    dimers in slow exchange on the NMR timescale with the corresponding monomers.
    The nature and structure of the dimers was evidenced by 2D NOESY and DOSY spectroscopy,
    mass spectrometry and X‐ray crystallography. The binding interface involves a
    large hydrophobic aromatic surface and hydrogen bonding. Dimerization requires
    that helices have the same handedness and the presence of a C‐terminal carboxy
    function. The protonation state of the carboxy group plays a crucial role, resulting
    in pH dependence of the association. Dimerization is also influenced by neighboring
    side chains and can be programmed to selectively produce heteromeric aggregates.
article_number: e202116509
article_processing_charge: No
article_type: original
author:
- first_name: Daniel
  full_name: Bindl, Daniel
  last_name: Bindl
- first_name: Pradeep K
  full_name: Mandal, Pradeep K
  id: 6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
  last_name: Mandal
  orcid: 0000-0001-5996-956X
- first_name: Lars
  full_name: Allmendinger, Lars
  last_name: Allmendinger
- first_name: Ivan
  full_name: Huc, Ivan
  last_name: Huc
citation:
  ama: Bindl D, Mandal PK, Allmendinger L, Huc I. Discrete stacked dimers of aromatic
    oligoamide helices. <i>Angewandte Chemie International Edition</i>. 2022;61(11).
    doi:<a href="https://doi.org/10.1002/anie.202116509">10.1002/anie.202116509</a>
  apa: Bindl, D., Mandal, P. K., Allmendinger, L., &#38; Huc, I. (2022). Discrete
    stacked dimers of aromatic oligoamide helices. <i>Angewandte Chemie International
    Edition</i>. Wiley. <a href="https://doi.org/10.1002/anie.202116509">https://doi.org/10.1002/anie.202116509</a>
  chicago: Bindl, Daniel, Pradeep K Mandal, Lars Allmendinger, and Ivan Huc. “Discrete
    Stacked Dimers of Aromatic Oligoamide Helices.” <i>Angewandte Chemie International
    Edition</i>. Wiley, 2022. <a href="https://doi.org/10.1002/anie.202116509">https://doi.org/10.1002/anie.202116509</a>.
  ieee: D. Bindl, P. K. Mandal, L. Allmendinger, and I. Huc, “Discrete stacked dimers
    of aromatic oligoamide helices,” <i>Angewandte Chemie International Edition</i>,
    vol. 61, no. 11. Wiley, 2022.
  ista: Bindl D, Mandal PK, Allmendinger L, Huc I. 2022. Discrete stacked dimers of
    aromatic oligoamide helices. Angewandte Chemie International Edition. 61(11),
    e202116509.
  mla: Bindl, Daniel, et al. “Discrete Stacked Dimers of Aromatic Oligoamide Helices.”
    <i>Angewandte Chemie International Edition</i>, vol. 61, no. 11, e202116509, Wiley,
    2022, doi:<a href="https://doi.org/10.1002/anie.202116509">10.1002/anie.202116509</a>.
  short: D. Bindl, P.K. Mandal, L. Allmendinger, I. Huc, Angewandte Chemie International
    Edition 61 (2022).
date_created: 2026-01-29T15:08:44Z
date_published: 2022-03-07T00:00:00Z
date_updated: 2026-02-20T07:06:47Z
day: '07'
doi: 10.1002/anie.202116509
extern: '1'
external_id:
  pmid:
  - '34962351 '
has_accepted_license: '1'
intvolume: '        61'
issue: '11'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1002/anie.202116509
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
publication: Angewandte Chemie International Edition
publication_identifier:
  eissn:
  - 1521-3773
  issn:
  - 1433-7851
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Discrete stacked dimers of aromatic oligoamide helices
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 61
year: '2022'
...
---
_id: '17057'
abstract:
- lang: eng
  text: Martin Loose studied chemistry at the University of Heidelberg, Germany. He
    then joined Petra Schwille's group at the Max Planck Institute of Molecular Cell
    Biology and Genetics in Dresden, where he obtained his PhD degree in 2010 for
    work on self-organization and pattern formation in the bacterial Min protein system.
    He then moved to Tim Mitchison's lab at Harvard Medical School, Boston, USA for
    his postdoc, funded by Human Frontier Science Program (HSFP) and European Molecular
    Biology Organization (EMBO) long-term fellowships; there, he discovered that the
    bacterial cell division proteins FtsA and FtsZ self-organize into dynamic cytoskeletal
    patterns. Martin established his independent research group at the Institute of
    Science and Technology (IST) Austria in 2015, supported by an European Research
    Council (ERC) starting grant and HFSP Young Investigator Grant. His lab studies
    the self-organization of bacterial cell division and small GTPase networks.
article_number: jcs259715
article_processing_charge: No
author:
- first_name: Martin
  full_name: Loose, Martin
  id: 462D4284-F248-11E8-B48F-1D18A9856A87
  last_name: Loose
  orcid: 0000-0001-7309-9724
citation:
  ama: Loose M. <i>Cell Scientist to Watch – Martin Loose</i>. Vol 135. The Company
    of Biologists; 2022. doi:<a href="https://doi.org/10.1242/jcs.259715">10.1242/jcs.259715</a>
  apa: Loose, M. (2022). <i>Cell scientist to watch – Martin Loose</i>. <i>Journal
    of Cell Science</i> (Vol. 135). The Company of Biologists. <a href="https://doi.org/10.1242/jcs.259715">https://doi.org/10.1242/jcs.259715</a>
  chicago: Loose, Martin. <i>Cell Scientist to Watch – Martin Loose</i>. <i>Journal
    of Cell Science</i>. Vol. 135. The Company of Biologists, 2022. <a href="https://doi.org/10.1242/jcs.259715">https://doi.org/10.1242/jcs.259715</a>.
  ieee: M. Loose, <i>Cell scientist to watch – Martin Loose</i>, vol. 135, no. 2.
    The Company of Biologists, 2022.
  ista: Loose M. 2022. Cell scientist to watch – Martin Loose, The Company of Biologists,p.
  mla: Loose, Martin. “Cell Scientist to Watch – Martin Loose.” <i>Journal of Cell
    Science</i>, vol. 135, no. 2, jcs259715, The Company of Biologists, 2022, doi:<a
    href="https://doi.org/10.1242/jcs.259715">10.1242/jcs.259715</a>.
  short: M. Loose, Cell Scientist to Watch – Martin Loose, The Company of Biologists,
    2022.
date_created: 2024-05-28T13:28:30Z
date_published: 2022-01-19T00:00:00Z
date_updated: 2024-06-04T09:51:20Z
day: '19'
department:
- _id: MaLo
doi: 10.1242/jcs.259715
external_id:
  isi:
  - '000762665200015'
intvolume: '       135'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1242/jcs.259715
month: '01'
oa: 1
oa_version: Published Version
publication: Journal of Cell Science
publication_identifier:
  eissn:
  - 1477-9137
  issn:
  - 0021-9533
publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
status: public
title: Cell scientist to watch – Martin Loose
type: other_academic_publication
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 135
year: '2022'
...
---
_id: '17058'
abstract:
- lang: eng
  text: We compare the Manin-type conjecture for Campana points recently formulated
    by Pieropan, Smeets, Tanimoto and Várilly-Alvarado with an alternative prediction
    of Browning and Van Valckenborgh in the special case of the orbifold (P1,D), where
    D=1/2[0]+1/2[1]+1/2[∞]. We find that the two predicted leading constants do not
    agree, and we discuss whether thin sets could explain this discrepancy. Motivated
    by this, we provide a counterexample to the Manin-type conjecture for Campana
    points, by considering orbifolds corresponding to squareful values of binary quadratic
    forms.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Alec L
  full_name: Shute, Alec L
  id: 440EB050-F248-11E8-B48F-1D18A9856A87
  last_name: Shute
  orcid: 0000-0002-1812-2810
citation:
  ama: Shute AL. On the leading constant in the Manin-type conjecture for Campana
    points. <i>Acta Arithmetica</i>. 2022;204(4):317-346. doi:<a href="https://doi.org/10.4064/aa210430-1-7">10.4064/aa210430-1-7</a>
  apa: Shute, A. L. (2022). On the leading constant in the Manin-type conjecture for
    Campana points. <i>Acta Arithmetica</i>. Institute of Mathematics. <a href="https://doi.org/10.4064/aa210430-1-7">https://doi.org/10.4064/aa210430-1-7</a>
  chicago: Shute, Alec L. “On the Leading Constant in the Manin-Type Conjecture for
    Campana Points.” <i>Acta Arithmetica</i>. Institute of Mathematics, 2022. <a href="https://doi.org/10.4064/aa210430-1-7">https://doi.org/10.4064/aa210430-1-7</a>.
  ieee: A. L. Shute, “On the leading constant in the Manin-type conjecture for Campana
    points,” <i>Acta Arithmetica</i>, vol. 204, no. 4. Institute of Mathematics, pp.
    317–346, 2022.
  ista: Shute AL. 2022. On the leading constant in the Manin-type conjecture for Campana
    points. Acta Arithmetica. 204(4), 317–346.
  mla: Shute, Alec L. “On the Leading Constant in the Manin-Type Conjecture for Campana
    Points.” <i>Acta Arithmetica</i>, vol. 204, no. 4, Institute of Mathematics, 2022,
    pp. 317–46, doi:<a href="https://doi.org/10.4064/aa210430-1-7">10.4064/aa210430-1-7</a>.
  short: A.L. Shute, Acta Arithmetica 204 (2022) 317–346.
corr_author: '1'
date_created: 2024-05-28T13:39:26Z
date_published: 2022-08-22T00:00:00Z
date_updated: 2025-09-10T09:57:03Z
day: '22'
department:
- _id: TiBr
doi: 10.4064/aa210430-1-7
external_id:
  arxiv:
  - '2104.14946'
  isi:
  - '000844789100001'
intvolume: '       204'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2104.14946
month: '08'
oa: 1
oa_version: Preprint
page: 317-346
publication: Acta Arithmetica
publication_identifier:
  eissn:
  - 1730-6264
  issn:
  - 0065-1036
publication_status: published
publisher: Institute of Mathematics
quality_controlled: '1'
related_material:
  record:
  - id: '12077'
    relation: earlier_version
    status: public
scopus_import: '1'
status: public
title: On the leading constant in the Manin-type conjecture for Campana points
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 204
year: '2022'
...
---
_id: '17059'
abstract:
- lang: eng
  text: The recent focus on the efficiency of deep neural networks (DNNs) has led
    to significant work on model compression approaches, of which weight pruning is
    one of the most popular. At the same time, there is rapidly-growing computational
    support for efficiently executing the unstructured-sparse models obtained via
    pruning. Yet, most existing pruning methods minimize just the number of remaining
    weights, i.e. the size of the model, rather than optimizing for inference time.
    We address this gap by introducing SPDY, a new compression method which automatically
    determines layer-wise sparsity targets achieving a desired inference speedup on
    a given system, while minimizing accuracy loss. SPDY is the composition of two
    new techniques. The first is an efficient and general dynamic programming algorithm
    for solving constrained layer-wise compression problems, given a set of layer-wise
    error scores. The second technique is a local search procedure for automatically
    determining such scores in an accurate and robust manner. Experiments across popular
    vision and language models show that SPDY guarantees speedups while recovering
    higher accuracy relative to existing strategies, both for one-shot and gradual
    pruning scenarios, and is compatible with most existing pruning approaches. We
    also extend our approach to the recently-proposed task of pruning with very little
    data, where we achieve the best known accuracy recovery when pruning to the GPU-supported
    2:4 sparsity pattern.
acknowledgement: "We gratefully acknowledge funding from the European Research Council
  (ERC) under the European Union’s Horizon 2020 programme (grant agreement No 805223
  ScaleML),\r\nas well as computational support from AWS EC2. We thank Eldar Kurtic
  for code and hyper-parameters for BERT pruning, and the Neural Magic Team, notably
  Michael Goin and\r\nMark Kurtz, for support with their software."
alternative_title:
- PMLR
article_processing_charge: Yes
author:
- first_name: Elias
  full_name: Frantar, Elias
  id: 09a8f98d-ec99-11ea-ae11-c063a7b7fe5f
  last_name: Frantar
- first_name: Dan-Adrian
  full_name: Alistarh, Dan-Adrian
  id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
  last_name: Alistarh
  orcid: 0000-0003-3650-940X
citation:
  ama: 'Frantar E, Alistarh D-A. SPDY: Accurate pruning with speedup guarantees. In:
    <i>39th International Conference on Machine Learning</i>. Vol 162. ML Research
    Press; 2022:6726-6743.'
  apa: 'Frantar, E., &#38; Alistarh, D.-A. (2022). SPDY: Accurate pruning with speedup
    guarantees. In <i>39th International Conference on Machine Learning</i> (Vol.
    162, pp. 6726–6743). Baltimore, MD, United States: ML Research Press.'
  chicago: 'Frantar, Elias, and Dan-Adrian Alistarh. “SPDY: Accurate Pruning with
    Speedup Guarantees.” In <i>39th International Conference on Machine Learning</i>,
    162:6726–43. ML Research Press, 2022.'
  ieee: 'E. Frantar and D.-A. Alistarh, “SPDY: Accurate pruning with speedup guarantees,”
    in <i>39th International Conference on Machine Learning</i>, Baltimore, MD, United
    States, 2022, vol. 162, pp. 6726–6743.'
  ista: 'Frantar E, Alistarh D-A. 2022. SPDY: Accurate pruning with speedup guarantees.
    39th International Conference on Machine Learning. ICML: International Conference
    on Machine Learning, PMLR, vol. 162, 6726–6743.'
  mla: 'Frantar, Elias, and Dan-Adrian Alistarh. “SPDY: Accurate Pruning with Speedup
    Guarantees.” <i>39th International Conference on Machine Learning</i>, vol. 162,
    ML Research Press, 2022, pp. 6726–43.'
  short: E. Frantar, D.-A. Alistarh, in:, 39th International Conference on Machine
    Learning, ML Research Press, 2022, pp. 6726–6743.
conference:
  end_date: 2022-07-23
  location: Baltimore, MD, United States
  name: 'ICML: International Conference on Machine Learning'
  start_date: 2022-07-17
corr_author: '1'
date_created: 2024-05-28T13:45:20Z
date_published: 2022-07-20T00:00:00Z
date_updated: 2025-04-14T07:49:14Z
day: '20'
ddc:
- '000'
department:
- _id: DaAl
ec_funded: 1
external_id:
  isi:
  - '000922378801029'
file:
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  checksum: 5179a1e4dfc0fbfab6674907299e414a
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  creator: dernst
  date_created: 2024-08-19T06:54:41Z
  date_updated: 2024-08-19T06:54:41Z
  file_id: '17440'
  file_name: 2022_PMLR_Frantar.pdf
  file_size: 615916
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  success: 1
file_date_updated: 2024-08-19T06:54:41Z
has_accepted_license: '1'
intvolume: '       162'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 6726-6743
project:
- _id: 268A44D6-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '805223'
  name: Elastic Coordination for Scalable Machine Learning
publication: 39th International Conference on Machine Learning
publication_status: published
publisher: ML Research Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'SPDY: Accurate pruning with speedup guarantees'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 162
year: '2022'
...
---
_id: '17060'
abstract:
- lang: eng
  text: "Payment channel networks (PCNs) are one of the most prominent solutions to
    the limited transaction throughput of blockchains. Nevertheless, PCNs suffer themselves
    from a throughput limitation due to the capital constraints of their channels.
    A similar dependence on high capital is also found in inter-bank payment settlements,
    where the so-called netting technique is used to mitigate liquidity demands.\r\nIn
    this work, we alleviate this limitation by introducing the notion of transaction
    aggregation: instead of executing transactions sequentially through a PCN, we
    enable senders to aggregate multiple transactions and execute them simultaneously
    to benefit from several amounts that may \"cancel out\". Two direct advantages
    of our proposal is the decrease in intermediary fees paid by senders as well as
    the obfuscation of the transaction data from the intermediaries.\r\nWe formulate
    the transaction aggregation as a computational problem, a generalization of the
    Bank Clearing Problem. We present a generic framework for the transaction aggregation
    execution, and thereafter we propose Wiser as an implementation of this framework
    in a specific hub-based setting. To overcome the NP-hardness of the transaction
    aggregation problem, in Wiser we propose a fixed-parameter linear algorithm for
    a special case of transaction aggregation as well as the Bank Clearing Problem.
    Wiser can also be seen as a modern variant of the Hawala money transfer system,
    as well as a decentralized implementation of the overseas remittance service of
    Wise."
acknowledgement: "This work was supported partially by ERC Starting Grant QIP–805241,
  by the Vienna business agency (Wirtschaftsagentur) through the Vienna Cybersecurity
  and Privacy Research Center\r\n(ViSP) and by the Austrian Science Fund (FWF) project
  I 4800-N (ADVISE).\r\nThe first author would like to thank Daniel Dadush for suggesting
  the use of discrepancy techniques to solve the transaction aggregation problem."
article_processing_charge: Yes (in subscription journal)
arxiv: 1
author:
- first_name: Samarth
  full_name: Tiwari, Samarth
  last_name: Tiwari
- first_name: Michelle X
  full_name: Yeo, Michelle X
  id: 2D82B818-F248-11E8-B48F-1D18A9856A87
  last_name: Yeo
  orcid: 0009-0001-3676-4809
- first_name: Zeta
  full_name: Avarikioti, Zeta
  last_name: Avarikioti
- first_name: Iosif
  full_name: Salem, Iosif
  last_name: Salem
- first_name: Krzysztof Z
  full_name: Pietrzak, Krzysztof Z
  id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
  last_name: Pietrzak
  orcid: 0000-0002-9139-1654
- first_name: Stefan
  full_name: Schmid, Stefan
  last_name: Schmid
citation:
  ama: 'Tiwari S, Yeo MX, Avarikioti Z, Salem I, Pietrzak KZ, Schmid S. Wiser: Increasing
    throughput in payment channel networks with transaction aggregation. In: <i>Proceedings
    of the 4th ACM Conference on Advances in Financial Technologies</i>. Association
    for Computing Machinery; 2022:217-231. doi:<a href="https://doi.org/10.1145/3558535.3559775">10.1145/3558535.3559775</a>'
  apa: 'Tiwari, S., Yeo, M. X., Avarikioti, Z., Salem, I., Pietrzak, K. Z., &#38;
    Schmid, S. (2022). Wiser: Increasing throughput in payment channel networks with
    transaction aggregation. In <i>Proceedings of the 4th ACM Conference on Advances
    in Financial Technologies</i> (pp. 217–231). Cambridge, MA, United States: Association
    for Computing Machinery. <a href="https://doi.org/10.1145/3558535.3559775">https://doi.org/10.1145/3558535.3559775</a>'
  chicago: 'Tiwari, Samarth, Michelle X Yeo, Zeta Avarikioti, Iosif Salem, Krzysztof
    Z Pietrzak, and Stefan Schmid. “Wiser: Increasing Throughput in Payment Channel
    Networks with Transaction Aggregation.” In <i>Proceedings of the 4th ACM Conference
    on Advances in Financial Technologies</i>, 217–31. Association for Computing Machinery,
    2022. <a href="https://doi.org/10.1145/3558535.3559775">https://doi.org/10.1145/3558535.3559775</a>.'
  ieee: 'S. Tiwari, M. X. Yeo, Z. Avarikioti, I. Salem, K. Z. Pietrzak, and S. Schmid,
    “Wiser: Increasing throughput in payment channel networks with transaction aggregation,”
    in <i>Proceedings of the 4th ACM Conference on Advances in Financial Technologies</i>,
    Cambridge, MA, United States, 2022, pp. 217–231.'
  ista: 'Tiwari S, Yeo MX, Avarikioti Z, Salem I, Pietrzak KZ, Schmid S. 2022. Wiser:
    Increasing throughput in payment channel networks with transaction aggregation.
    Proceedings of the 4th ACM Conference on Advances in Financial Technologies. AFT:
    Conference on Advances in Financial Technologies, 217–231.'
  mla: 'Tiwari, Samarth, et al. “Wiser: Increasing Throughput in Payment Channel Networks
    with Transaction Aggregation.” <i>Proceedings of the 4th ACM Conference on Advances
    in Financial Technologies</i>, Association for Computing Machinery, 2022, pp.
    217–31, doi:<a href="https://doi.org/10.1145/3558535.3559775">10.1145/3558535.3559775</a>.'
  short: S. Tiwari, M.X. Yeo, Z. Avarikioti, I. Salem, K.Z. Pietrzak, S. Schmid, in:,
    Proceedings of the 4th ACM Conference on Advances in Financial Technologies, Association
    for Computing Machinery, 2022, pp. 217–231.
conference:
  end_date: 2022-09-21
  location: Cambridge, MA, United States
  name: 'AFT: Conference on Advances in Financial Technologies'
  start_date: 2022-09-19
date_created: 2024-05-28T13:58:35Z
date_published: 2022-09-19T00:00:00Z
date_updated: 2025-09-10T09:57:48Z
day: '19'
ddc:
- '000'
department:
- _id: KrPi
doi: 10.1145/3558535.3559775
external_id:
  arxiv:
  - '2205.11597'
  isi:
  - '001041852800015'
file:
- access_level: open_access
  checksum: 54a7d405f8e57dba24728599ca63818c
  content_type: application/pdf
  creator: dernst
  date_created: 2024-08-19T06:45:21Z
  date_updated: 2024-08-19T06:45:21Z
  file_id: '17439'
  file_name: 2022_AFT_Tiwari.pdf
  file_size: 574728
  relation: main_file
  success: 1
file_date_updated: 2024-08-19T06:45:21Z
has_accepted_license: '1'
isi: 1
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 217-231
publication: Proceedings of the 4th ACM Conference on Advances in Financial Technologies
publication_identifier:
  isbn:
  - '9781450398619'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Wiser: Increasing throughput in payment channel networks with transaction
  aggregation'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
year: '2022'
...
---
_id: '17061'
abstract:
- lang: eng
  text: Across many domains of interaction, both natural and artificial, individuals
    use past experience to shape future behaviors. The results of such learning processes
    depend on what individuals wish to maximize. A natural objective is one’s own
    success. However, when two such “selfish” learners interact with each other, the
    outcome can be detrimental to both, especially when there are conflicts of interest.
    Here, we explore how a learner can align incentives with a selfish opponent. Moreover,
    we consider the dynamics that arise when learning rules themselves are subject
    to evolutionary pressure. By combining extensive simulations and analytical techniques,
    we demonstrate that selfish learning is unstable in most classical two-player
    repeated games. If evolution operates on the level of long-run payoffs, selection
    instead favors learning rules that incorporate social (other-regarding) preferences.
    To further corroborate these results, we analyze data from a repeated prisoner’s
    dilemma experiment. We find that selfish learning is insufficient to explain human
    behavior when there is a trade-off between payoff maximization and fairness.
acknowledgement: The authors are grateful to Jörg Oechssler for many helpful comments.
  A.M. was supported by a Simons Postdoctoral Fellowship (Math+X) at the University
  of Pennsylvania; K.C. was supported by the European Research Council Consolidator
  Grant 863818 (ForM-SMArt); and C.H. was supported by the European Research Council
  Starting Grant 850529 (E-DIRECT).
article_number: pgac141
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Alex
  full_name: McAvoy, Alex
  last_name: McAvoy
- first_name: Julian
  full_name: Kates-Harbeck, Julian
  last_name: Kates-Harbeck
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Christian
  full_name: Hilbe, Christian
  id: 2FDF8F3C-F248-11E8-B48F-1D18A9856A87
  last_name: Hilbe
  orcid: 0000-0001-5116-955X
citation:
  ama: McAvoy A, Kates-Harbeck J, Chatterjee K, Hilbe C. Evolutionary instability
    of selfish learning in repeated games. <i>PNAS Nexus</i>. 2022;1(4). doi:<a href="https://doi.org/10.1093/pnasnexus/pgac141">10.1093/pnasnexus/pgac141</a>
  apa: McAvoy, A., Kates-Harbeck, J., Chatterjee, K., &#38; Hilbe, C. (2022). Evolutionary
    instability of selfish learning in repeated games. <i>PNAS Nexus</i>. Oxford University
    Press. <a href="https://doi.org/10.1093/pnasnexus/pgac141">https://doi.org/10.1093/pnasnexus/pgac141</a>
  chicago: McAvoy, Alex, Julian Kates-Harbeck, Krishnendu Chatterjee, and Christian
    Hilbe. “Evolutionary Instability of Selfish Learning in Repeated Games.” <i>PNAS
    Nexus</i>. Oxford University Press, 2022. <a href="https://doi.org/10.1093/pnasnexus/pgac141">https://doi.org/10.1093/pnasnexus/pgac141</a>.
  ieee: A. McAvoy, J. Kates-Harbeck, K. Chatterjee, and C. Hilbe, “Evolutionary instability
    of selfish learning in repeated games,” <i>PNAS Nexus</i>, vol. 1, no. 4. Oxford
    University Press, 2022.
  ista: McAvoy A, Kates-Harbeck J, Chatterjee K, Hilbe C. 2022. Evolutionary instability
    of selfish learning in repeated games. PNAS Nexus. 1(4), pgac141.
  mla: McAvoy, Alex, et al. “Evolutionary Instability of Selfish Learning in Repeated
    Games.” <i>PNAS Nexus</i>, vol. 1, no. 4, pgac141, Oxford University Press, 2022,
    doi:<a href="https://doi.org/10.1093/pnasnexus/pgac141">10.1093/pnasnexus/pgac141</a>.
  short: A. McAvoy, J. Kates-Harbeck, K. Chatterjee, C. Hilbe, PNAS Nexus 1 (2022).
date_created: 2024-05-28T14:23:12Z
date_published: 2022-09-01T00:00:00Z
date_updated: 2025-06-11T13:54:20Z
day: '01'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1093/pnasnexus/pgac141
ec_funded: 1
external_id:
  arxiv:
  - '2105.06199'
  pmid:
  - '36714856'
file:
- access_level: open_access
  checksum: 79a8e3e4be7e8a2b407b4efddd65f3f3
  content_type: application/pdf
  creator: dernst
  date_created: 2024-08-06T07:33:30Z
  date_updated: 2024-08-06T07:33:30Z
  file_id: '17400'
  file_name: 2022_PNASNexus_McAvoy.pdf
  file_size: 2410962
  relation: main_file
  success: 1
file_date_updated: 2024-08-06T07:33:30Z
has_accepted_license: '1'
intvolume: '         1'
issue: '4'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
  call_identifier: H2020
  grant_number: '863818'
  name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
publication: PNAS Nexus
publication_identifier:
  issn:
  - 2752-6542
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
related_material:
  link:
  - relation: software
    url: https://github.com/alexmcavoy/fmtl/
scopus_import: '1'
status: public
title: Evolutionary instability of selfish learning in repeated games
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1
year: '2022'
...
---
_id: '17062'
acknowledgement: "Werner Siemens Foundation\r\nEuropean Union's Horizon 2020\r\nFWF
  “Lise Meitner Fellowship”"
article_number: '159'
article_processing_charge: No
author:
- first_name: Maria
  full_name: Ibáñez, Maria
  id: 43C61214-F248-11E8-B48F-1D18A9856A87
  last_name: Ibáñez
  orcid: 0000-0001-5013-2843
- first_name: Yu
  full_name: Liu, Yu
  id: 2A70014E-F248-11E8-B48F-1D18A9856A87
  last_name: Liu
  orcid: 0000-0001-7313-6740
- first_name: Mariano
  full_name: Calcabrini, Mariano
  id: 45D7531A-F248-11E8-B48F-1D18A9856A87
  last_name: Calcabrini
  orcid: 0000-0003-4566-5877
citation:
  ama: 'Ibáñez M, Liu Y, Calcabrini M. The importance of surface adsorbates in solution-processed
    thermoelectric materials. In: <i>Proceedings of the NanoGe Spring Meeting 2022</i>.
    Fundació Scito; 2022. doi:<a href="https://doi.org/10.29363/nanoge.nsm.2022.159">10.29363/nanoge.nsm.2022.159</a>'
  apa: 'Ibáñez, M., Liu, Y., &#38; Calcabrini, M. (2022). The importance of surface
    adsorbates in solution-processed thermoelectric materials. In <i>Proceedings of
    the nanoGe Spring Meeting 2022</i>. Spain/Virtual: Fundació Scito. <a href="https://doi.org/10.29363/nanoge.nsm.2022.159">https://doi.org/10.29363/nanoge.nsm.2022.159</a>'
  chicago: Ibáñez, Maria, Yu Liu, and Mariano Calcabrini. “The Importance of Surface
    Adsorbates in Solution-Processed Thermoelectric Materials.” In <i>Proceedings
    of the NanoGe Spring Meeting 2022</i>. Fundació Scito, 2022. <a href="https://doi.org/10.29363/nanoge.nsm.2022.159">https://doi.org/10.29363/nanoge.nsm.2022.159</a>.
  ieee: M. Ibáñez, Y. Liu, and M. Calcabrini, “The importance of surface adsorbates
    in solution-processed thermoelectric materials,” in <i>Proceedings of the nanoGe
    Spring Meeting 2022</i>, Spain/Virtual, 2022.
  ista: 'Ibáñez M, Liu Y, Calcabrini M. 2022. The importance of surface adsorbates
    in solution-processed thermoelectric materials. Proceedings of the nanoGe Spring
    Meeting 2022. SNI: Semiconductor Nanocrystals, 159.'
  mla: Ibáñez, Maria, et al. “The Importance of Surface Adsorbates in Solution-Processed
    Thermoelectric Materials.” <i>Proceedings of the NanoGe Spring Meeting 2022</i>,
    159, Fundació Scito, 2022, doi:<a href="https://doi.org/10.29363/nanoge.nsm.2022.159">10.29363/nanoge.nsm.2022.159</a>.
  short: M. Ibáñez, Y. Liu, M. Calcabrini, in:, Proceedings of the NanoGe Spring Meeting
    2022, Fundació Scito, 2022.
conference:
  end_date: 2022-03-11
  location: Spain/Virtual
  name: 'SNI: Semiconductor Nanocrystals'
  start_date: 2022-03-07
corr_author: '1'
date_created: 2024-05-29T05:38:47Z
date_published: 2022-02-07T00:00:00Z
date_updated: 2025-04-15T06:54:34Z
day: '07'
department:
- _id: MaIb
doi: 10.29363/nanoge.nsm.2022.159
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.29363/nanoge.nsm.2022.159
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: 9B8F7476-BA93-11EA-9121-9846C619BF3A
  name: 'HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of
    Semiconductors for Waste Heat Recovery'
publication: Proceedings of the nanoGe Spring Meeting 2022
publication_status: published
publisher: Fundació Scito
quality_controlled: '1'
related_material:
  record:
  - id: '10123'
    relation: earlier_version
    status: public
status: public
title: The importance of surface adsorbates in solution-processed thermoelectric materials
type: conference_abstract
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '17063'
abstract:
- lang: eng
  text: This workshop continued a biannual series of workshops at Oberwolfach on dynamical
    systems that started with a meeting organized by Moser and Zehnder in 1981. Workshops
    in this series focus on new results and developments in dynamical systems and
    related areas of mathematics, with symplectic geometry playing an important role
    in recent years in connection with Hamiltonian dynamics. In this year special
    emphasis was placed on various kinds of spectra (in contact geometry, in Riemannian
    geometry, in dynamical systems and in symplectic topology) and their applications
    to dynamics.
article_processing_charge: No
article_type: original
author:
- first_name: Marie-Claude
  full_name: Arnaud, Marie-Claude
  last_name: Arnaud
- first_name: Helmut W.
  full_name: Hofer, Helmut W.
  last_name: Hofer
- first_name: Michael
  full_name: Hutchings, Michael
  last_name: Hutchings
- first_name: Vadim
  full_name: Kaloshin, Vadim
  id: FE553552-CDE8-11E9-B324-C0EBE5697425
  last_name: Kaloshin
  orcid: 0000-0002-6051-2628
citation:
  ama: Arnaud M-C, Hofer HW, Hutchings M, Kaloshin V. Dynamische Systeme. <i>Oberwolfach
    Reports</i>. 2022;18(3):1735-1803. doi:<a href="https://doi.org/10.4171/owr/2021/33">10.4171/owr/2021/33</a>
  apa: Arnaud, M.-C., Hofer, H. W., Hutchings, M., &#38; Kaloshin, V. (2022). Dynamische
    Systeme. <i>Oberwolfach Reports</i>. European Mathematical Society. <a href="https://doi.org/10.4171/owr/2021/33">https://doi.org/10.4171/owr/2021/33</a>
  chicago: Arnaud, Marie-Claude, Helmut W. Hofer, Michael Hutchings, and Vadim Kaloshin.
    “Dynamische Systeme.” <i>Oberwolfach Reports</i>. European Mathematical Society,
    2022. <a href="https://doi.org/10.4171/owr/2021/33">https://doi.org/10.4171/owr/2021/33</a>.
  ieee: M.-C. Arnaud, H. W. Hofer, M. Hutchings, and V. Kaloshin, “Dynamische Systeme,”
    <i>Oberwolfach Reports</i>, vol. 18, no. 3. European Mathematical Society, pp.
    1735–1803, 2022.
  ista: Arnaud M-C, Hofer HW, Hutchings M, Kaloshin V. 2022. Dynamische Systeme. Oberwolfach
    Reports. 18(3), 1735–1803.
  mla: Arnaud, Marie-Claude, et al. “Dynamische Systeme.” <i>Oberwolfach Reports</i>,
    vol. 18, no. 3, European Mathematical Society, 2022, pp. 1735–803, doi:<a href="https://doi.org/10.4171/owr/2021/33">10.4171/owr/2021/33</a>.
  short: M.-C. Arnaud, H.W. Hofer, M. Hutchings, V. Kaloshin, Oberwolfach Reports
    18 (2022) 1735–1803.
corr_author: '1'
date_created: 2024-05-29T06:01:19Z
date_published: 2022-11-26T00:00:00Z
date_updated: 2024-08-06T07:28:50Z
day: '26'
department:
- _id: VaKa
doi: 10.4171/owr/2021/33
intvolume: '        18'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.doi.org/10.4171/OWR/2021/33
month: '11'
oa: 1
oa_version: Published Version
page: 1735-1803
publication: Oberwolfach Reports
publication_identifier:
  eissn:
  - 1660-8941
  issn:
  - 1660-8933
publication_status: published
publisher: European Mathematical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dynamische Systeme
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 18
year: '2022'
...
---
_id: '17065'
abstract:
- lang: eng
  text: Past work on optimizing fabrication plans given a carpentry design can provide
    Pareto-optimal plans trading off between material waste, fabrication time, precision,
    and other considerations. However, when developing fabrication plans, experts
    rarely restrict to a single design, instead considering families of design variations,
    sometimes adjusting designs to simplify fabrication. Jointly exploring the design
    and fabrication plan spaces for each design is intractable using current techniques.
    We present a new approach to jointly optimize design and fabrication plans for
    carpentered objects. To make this bi-level optimization tractable, we adapt recent
    work from program synthesis based on equality graphs (e-graphs), which encode
    sets of equivalent programs. Our insight is that subproblems within our bi-level
    problem share significant substructures. By representing both designs and fabrication
    plans in a new bag of parts (BOP) e-graph, we amortize the cost of optimizing
    design components shared among multiple candidates. Even using BOP e-graphs, the
    optimization space grows quickly in practice. Hence, we also show how a feedback-guided
    search strategy dubbed Iterative Contraction and Expansion on E-graphs (ICEE)
    can keep the size of the e-graph manageable and direct the search towards promising
    candidates. We illustrate the advantages of our pipeline through examples from
    the carpentry domain.
acknowledgement: The authors would like to thank anonymous reviewers for their helpful
  feedback; Haomiao Wu for her contribution to the algorithm development in the early
  stage of the project; Elias Baldwin, David Tsay, Alexander Lefort, and Qiyang Tan
  for helping the experiments.
article_number: '32'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Haisen
  full_name: Zhao, Haisen
  id: fb7f793a-80d1-11eb-8869-d56e5b2a8ff4
  last_name: Zhao
  orcid: 0000-0002-6389-1045
- first_name: Max
  full_name: Willsey, Max
  last_name: Willsey
- first_name: Amy
  full_name: Zhu, Amy
  last_name: Zhu
- first_name: Chandrakana
  full_name: Nandi, Chandrakana
  last_name: Nandi
- first_name: Zachary
  full_name: Tatlock, Zachary
  last_name: Tatlock
- first_name: Justin
  full_name: Solomon, Justin
  last_name: Solomon
- first_name: Adriana
  full_name: Schulz, Adriana
  last_name: Schulz
citation:
  ama: Zhao H, Willsey M, Zhu A, et al. Co-optimization of design and fabrication
    plans for carpentry. <i>ACM Transactions on Graphics</i>. 2022;41(3). doi:<a href="https://doi.org/10.1145/3508499">10.1145/3508499</a>
  apa: Zhao, H., Willsey, M., Zhu, A., Nandi, C., Tatlock, Z., Solomon, J., &#38;
    Schulz, A. (2022). Co-optimization of design and fabrication plans for carpentry.
    <i>ACM Transactions on Graphics</i>. Association for Computing Machinery. <a href="https://doi.org/10.1145/3508499">https://doi.org/10.1145/3508499</a>
  chicago: Zhao, Haisen, Max Willsey, Amy Zhu, Chandrakana Nandi, Zachary Tatlock,
    Justin Solomon, and Adriana Schulz. “Co-Optimization of Design and Fabrication
    Plans for Carpentry.” <i>ACM Transactions on Graphics</i>. Association for Computing
    Machinery, 2022. <a href="https://doi.org/10.1145/3508499">https://doi.org/10.1145/3508499</a>.
  ieee: H. Zhao <i>et al.</i>, “Co-optimization of design and fabrication plans for
    carpentry,” <i>ACM Transactions on Graphics</i>, vol. 41, no. 3. Association for
    Computing Machinery, 2022.
  ista: Zhao H, Willsey M, Zhu A, Nandi C, Tatlock Z, Solomon J, Schulz A. 2022. Co-optimization
    of design and fabrication plans for carpentry. ACM Transactions on Graphics. 41(3),
    32.
  mla: Zhao, Haisen, et al. “Co-Optimization of Design and Fabrication Plans for Carpentry.”
    <i>ACM Transactions on Graphics</i>, vol. 41, no. 3, 32, Association for Computing
    Machinery, 2022, doi:<a href="https://doi.org/10.1145/3508499">10.1145/3508499</a>.
  short: H. Zhao, M. Willsey, A. Zhu, C. Nandi, Z. Tatlock, J. Solomon, A. Schulz,
    ACM Transactions on Graphics 41 (2022).
date_created: 2024-05-29T06:09:23Z
date_published: 2022-03-09T00:00:00Z
date_updated: 2024-08-06T07:03:14Z
day: '09'
department:
- _id: BeBi
doi: 10.1145/3508499
external_id:
  arxiv:
  - '2107.12265'
intvolume: '        41'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2107.12265
month: '03'
oa: 1
oa_version: Preprint
publication: ACM Transactions on Graphics
publication_identifier:
  eissn:
  - 1557-7368
  issn:
  - 0730-0301
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Co-optimization of design and fabrication plans for carpentry
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 41
year: '2022'
...
---
_id: '17066'
abstract:
- lang: eng
  text: A cell’s size affects the likelihood that it will die. But how is cell size
    controlled in this context and how does cell size impact commitment to the cell
    death fate? We present evidence that the caspase CED-3 interacts with the RhoGEF
    ECT-2 in Caenorhabditis elegans neuroblasts that generate “unwanted” cells. We
    propose that this interaction promotes polar actomyosin contractility, which leads
    to unequal neuroblast division and the generation of a daughter cell that is below
    the critical “lethal” size threshold. Furthermore, we find that hyperactivation
    of ECT-2 RhoGEF reduces the sizes of unwanted cells. Importantly, this suppresses
    the “cell death abnormal” phenotype caused by the partial loss of ced-3 caspase
    and therefore increases the likelihood that unwanted cells die. A putative null
    mutation of ced-3 caspase, however, is not suppressed, which indicates that cell
    size affects CED-3 caspase activation and/or activity. Therefore, we have uncovered
    novel sequential and reciprocal interactions between the apoptosis pathway and
    cell size that impact a cell’s commitment to the cell death fate.
acknowledgement: "We thank members of the Conradt, Lambie, and Hajnal labs for discussions
  and comments on the manuscript. We thank M. Bauer, L. Jocham, N. Lebedeva, and L.
  McGuinness for excellent technical support; A. Hajnal and T. Kohlbrenner (University
  of Zurich, Switzerland) for allele zh135; and H.R. Horvitz (Massachusetts of Technology,
  USA) for plasmid pET-CED-3.\r\nSome strains were provided by the Caenorhabditis
  Genetics Center (CGC), which is funded by NIH Office of Research Infrastructure
  Programs (https://orip.nih.gov/) (P40 OD010440). This work was supported by UCL
  (Capital Equipment Fund, CEF2), a predoctoral fellowship from the China Scholarship
  Council (https://www.csc.edu.cn/) to HW, a predoctoral fellowship from the Studienstiftung
  des Deutschen Volkes (https://www.studienstiftung.de/) to NM, a Wolfson Fellowship
  from the Royal Society (https://royalsociety.org/) to BC (RSWF\\R1\\180008), the
  Deutsche Forschungsgemeinschaft (https://www.dfg.de/en/index.jsp) (ZA619/3-1 and
  ZA619/3-2 to EZ; C0204/10-1 and EXC114 to BC), and the Biotechnology and Biological
  Sciences Research Council (https://bbsrc.ukri.org/) (BB/V007572/1 to BC). "
article_number: e3001786
article_processing_charge: Yes
article_type: original
author:
- first_name: Aditya
  full_name: Sethi, Aditya
  last_name: Sethi
- first_name: Hai
  full_name: Wei, Hai
  last_name: Wei
- first_name: Nikhil
  full_name: Mishra, Nikhil
  id: C4D70E82-1081-11EA-B3ED-9A4C3DDC885E
  last_name: Mishra
  orcid: 0000-0002-6425-5788
- first_name: Ioannis
  full_name: Segos, Ioannis
  last_name: Segos
- first_name: Eric J.
  full_name: Lambie, Eric J.
  last_name: Lambie
- first_name: Esther
  full_name: Zanin, Esther
  last_name: Zanin
- first_name: Barbara
  full_name: Conradt, Barbara
  last_name: Conradt
citation:
  ama: Sethi A, Wei H, Mishra N, et al. A caspase–RhoGEF axis contributes to the cell
    size threshold for apoptotic death in developing Caenorhabditis elegans. <i>PLOS
    Biology</i>. 2022;20(10). doi:<a href="https://doi.org/10.1371/journal.pbio.3001786">10.1371/journal.pbio.3001786</a>
  apa: Sethi, A., Wei, H., Mishra, N., Segos, I., Lambie, E. J., Zanin, E., &#38;
    Conradt, B. (2022). A caspase–RhoGEF axis contributes to the cell size threshold
    for apoptotic death in developing Caenorhabditis elegans. <i>PLOS Biology</i>.
    Public Library of Science. <a href="https://doi.org/10.1371/journal.pbio.3001786">https://doi.org/10.1371/journal.pbio.3001786</a>
  chicago: Sethi, Aditya, Hai Wei, Nikhil Mishra, Ioannis Segos, Eric J. Lambie, Esther
    Zanin, and Barbara Conradt. “A Caspase–RhoGEF Axis Contributes to the Cell Size
    Threshold for Apoptotic Death in Developing Caenorhabditis Elegans.” <i>PLOS Biology</i>.
    Public Library of Science, 2022. <a href="https://doi.org/10.1371/journal.pbio.3001786">https://doi.org/10.1371/journal.pbio.3001786</a>.
  ieee: A. Sethi <i>et al.</i>, “A caspase–RhoGEF axis contributes to the cell size
    threshold for apoptotic death in developing Caenorhabditis elegans,” <i>PLOS Biology</i>,
    vol. 20, no. 10. Public Library of Science, 2022.
  ista: Sethi A, Wei H, Mishra N, Segos I, Lambie EJ, Zanin E, Conradt B. 2022. A
    caspase–RhoGEF axis contributes to the cell size threshold for apoptotic death
    in developing Caenorhabditis elegans. PLOS Biology. 20(10), e3001786.
  mla: Sethi, Aditya, et al. “A Caspase–RhoGEF Axis Contributes to the Cell Size Threshold
    for Apoptotic Death in Developing Caenorhabditis Elegans.” <i>PLOS Biology</i>,
    vol. 20, no. 10, e3001786, Public Library of Science, 2022, doi:<a href="https://doi.org/10.1371/journal.pbio.3001786">10.1371/journal.pbio.3001786</a>.
  short: A. Sethi, H. Wei, N. Mishra, I. Segos, E.J. Lambie, E. Zanin, B. Conradt,
    PLOS Biology 20 (2022).
date_created: 2024-05-29T06:09:34Z
date_published: 2022-10-06T00:00:00Z
date_updated: 2024-08-06T07:08:54Z
day: '06'
ddc:
- '570'
department:
- _id: CaHe
doi: 10.1371/journal.pbio.3001786
external_id:
  pmid:
  - '36201522'
file:
- access_level: open_access
  checksum: a7b46460b7819c196028481cc18a7c85
  content_type: application/pdf
  creator: dernst
  date_created: 2024-08-06T07:07:52Z
  date_updated: 2024-08-06T07:07:52Z
  file_id: '17399'
  file_name: 2022_PlosBio_Sethi.pdf
  file_size: 2515388
  relation: main_file
  success: 1
file_date_updated: 2024-08-06T07:07:52Z
has_accepted_license: '1'
intvolume: '        20'
issue: '10'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
publication: PLOS Biology
publication_identifier:
  issn:
  - 1545-7885
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: A caspase–RhoGEF axis contributes to the cell size threshold for apoptotic
  death in developing Caenorhabditis elegans
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '2022'
...
---
_id: '17067'
abstract:
- lang: eng
  text: 'Human doublecortin (DCX) mutations are associated with severe brain malformations
    leading to aberrant neuron positioning (heterotopia), intellectual disability
    and epilepsy. DCX is a microtubule-associated protein which plays a key role during
    neurodevelopment in neuronal migration and differentiation. Dcx knockout (KO)
    mice show disorganized hippocampal pyramidal neurons. The CA2/CA3 pyramidal cell
    layer is present as two abnormal layers and disorganized CA3 KO pyramidal neurons
    are also more excitable than wild-type (WT) cells. To further identify abnormalities,
    we characterized Dcx KO hippocampal neurons at subcellular, molecular and ultrastructural
    levels. Severe defects were observed in mitochondria, affecting number and distribution.
    Also, the Golgi apparatus was visibly abnormal, increased in volume and abnormally
    organized. Transcriptome analyses from laser microdissected hippocampal tissue
    at postnatal day 60 (P60) highlighted organelle abnormalities. Ultrastructural
    studies of CA3 cells performed in P60 (young adult) and > 9 months (mature) tissue
    showed that organelle defects are persistent throughout life. Locomotor activity
    and fear memory of young and mature adults were also abnormal: Dcx KO mice consistently
    performed less well than WT littermates, with defects becoming more severe with
    age. Thus, we show that disruption of a neurodevelopmentally-regulated gene can
    lead to permanent organelle anomalies contributing to abnormal adult behavior.'
acknowledgement: "We thank Sylvie Dumont for initial aid with laser microdissection
  and G. Martinez-Lorenzana for experimental help with electron microscopy. We thank
  the animal experimentation facility and cellular and tissue imaging platforms at
  the Institut du Fer à Moulin, supported also by the Région Ile de France and the
  FRC Rotary. The Francis lab was associated with the BioPsy Labex project and the
  Ecole des Neurosciences de Paris Ile-de-France (ENP) network. Our salaries and lab
  were supported by Inserm, the Centre national de la recherche scientifique (CNRS)
  and Sorbonne University. The Francis group obtained the following funding contributing
  to this project: the European Union (EU- HEALTH-2013, DESIRE, N° 60253), the JTC
  2015 Neurodevelopmental Disorders affiliated with the French Agence National de
  la Recherche (for \r\nNEURON8-Full- 815-006 STEM-MCD, to FF), E-Rare-3, the ERA-Net
  for Research on Rare Diseases affiliated with the French ANR (ERARE18-049), the
  European Cooperation on Science and Technology (COST Action CA16118)."
article_number: '105702'
article_processing_charge: Yes
article_type: original
author:
- first_name: Melissa A
  full_name: Stouffer, Melissa A
  id: 4C9372C4-F248-11E8-B48F-1D18A9856A87
  last_name: Stouffer
- first_name: R.
  full_name: Khalaf-Nazzal, R.
  last_name: Khalaf-Nazzal
- first_name: C.
  full_name: Cifuentes-Diaz, C.
  last_name: Cifuentes-Diaz
- first_name: G.
  full_name: Albertini, G.
  last_name: Albertini
- first_name: E.
  full_name: Bandet, E.
  last_name: Bandet
- first_name: G.
  full_name: Grannec, G.
  last_name: Grannec
- first_name: V.
  full_name: Lavilla, V.
  last_name: Lavilla
- first_name: J.-F.
  full_name: Deleuze, J.-F.
  last_name: Deleuze
- first_name: R.
  full_name: Olaso, R.
  last_name: Olaso
- first_name: M.
  full_name: Nosten-Bertrand, M.
  last_name: Nosten-Bertrand
- first_name: F.
  full_name: Francis, F.
  last_name: Francis
citation:
  ama: Stouffer MA, Khalaf-Nazzal R, Cifuentes-Diaz C, et al. Doublecortin mutation
    leads to persistent defects in the Golgi apparatus and mitochondria in adult hippocampal
    pyramidal cells. <i>Neurobiology of Disease</i>. 2022;168. doi:<a href="https://doi.org/10.1016/j.nbd.2022.105702">10.1016/j.nbd.2022.105702</a>
  apa: Stouffer, M. A., Khalaf-Nazzal, R., Cifuentes-Diaz, C., Albertini, G., Bandet,
    E., Grannec, G., … Francis, F. (2022). Doublecortin mutation leads to persistent
    defects in the Golgi apparatus and mitochondria in adult hippocampal pyramidal
    cells. <i>Neurobiology of Disease</i>. Elsevier. <a href="https://doi.org/10.1016/j.nbd.2022.105702">https://doi.org/10.1016/j.nbd.2022.105702</a>
  chicago: Stouffer, Melissa A, R. Khalaf-Nazzal, C. Cifuentes-Diaz, G. Albertini,
    E. Bandet, G. Grannec, V. Lavilla, et al. “Doublecortin Mutation Leads to Persistent
    Defects in the Golgi Apparatus and Mitochondria in Adult Hippocampal Pyramidal
    Cells.” <i>Neurobiology of Disease</i>. Elsevier, 2022. <a href="https://doi.org/10.1016/j.nbd.2022.105702">https://doi.org/10.1016/j.nbd.2022.105702</a>.
  ieee: M. A. Stouffer <i>et al.</i>, “Doublecortin mutation leads to persistent defects
    in the Golgi apparatus and mitochondria in adult hippocampal pyramidal cells,”
    <i>Neurobiology of Disease</i>, vol. 168. Elsevier, 2022.
  ista: Stouffer MA, Khalaf-Nazzal R, Cifuentes-Diaz C, Albertini G, Bandet E, Grannec
    G, Lavilla V, Deleuze J-F, Olaso R, Nosten-Bertrand M, Francis F. 2022. Doublecortin
    mutation leads to persistent defects in the Golgi apparatus and mitochondria in
    adult hippocampal pyramidal cells. Neurobiology of Disease. 168, 105702.
  mla: Stouffer, Melissa A., et al. “Doublecortin Mutation Leads to Persistent Defects
    in the Golgi Apparatus and Mitochondria in Adult Hippocampal Pyramidal Cells.”
    <i>Neurobiology of Disease</i>, vol. 168, 105702, Elsevier, 2022, doi:<a href="https://doi.org/10.1016/j.nbd.2022.105702">10.1016/j.nbd.2022.105702</a>.
  short: M.A. Stouffer, R. Khalaf-Nazzal, C. Cifuentes-Diaz, G. Albertini, E. Bandet,
    G. Grannec, V. Lavilla, J.-F. Deleuze, R. Olaso, M. Nosten-Bertrand, F. Francis,
    Neurobiology of Disease 168 (2022).
date_created: 2024-05-29T06:10:05Z
date_published: 2022-06-15T00:00:00Z
date_updated: 2024-08-06T06:57:39Z
day: '15'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1016/j.nbd.2022.105702
external_id:
  pmid:
  - '35339680'
file:
- access_level: open_access
  checksum: b705d3d23d0b424ba29920be7ab64c23
  content_type: application/pdf
  creator: dernst
  date_created: 2024-08-06T06:54:24Z
  date_updated: 2024-08-06T06:54:24Z
  file_id: '17398'
  file_name: 2022_NeurobioDisease_Stouffer.pdf
  file_size: 8890818
  relation: main_file
  success: 1
file_date_updated: 2024-08-06T06:54:24Z
has_accepted_license: '1'
intvolume: '       168'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
publication: Neurobiology of Disease
publication_identifier:
  issn:
  - 0969-9961
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Doublecortin mutation leads to persistent defects in the Golgi apparatus and
  mitochondria in adult hippocampal pyramidal cells
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 168
year: '2022'
...
---
_id: '17068'
abstract:
- lang: eng
  text: In plants, the antagonism between growth and defense is hardwired by hormonal
    signaling. The perception of pathogen-associated molecular patterns (PAMPs) from
    invading microorganisms inhibits auxin signaling and plant growth. Conversely,
    pathogens manipulate auxin signaling to promote disease, but how this hormone
    inhibits immunity is not fully understood. Ustilago maydis is a maize pathogen
    that induces auxin signaling in its host. We characterized a U. maydis effector
    protein, Naked1 (Nkd1), that is translocated into the host nucleus. Through its
    native ethylene-responsive element binding factor-associated amphiphilic repression
    (EAR) motif, Nkd1 binds to the transcriptional co-repressors TOPLESS/TOPLESS-related
    (TPL/TPRs) and prevents the recruitment of a transcriptional repressor involved
    in hormonal signaling, leading to the de-repression of auxin and jasmonate signaling
    and thereby promoting susceptibility to (hemi)biotrophic pathogens. A moderate
    upregulation of auxin signaling inhibits the PAMP-triggered reactive oxygen species
    (ROS) burst, an early defense response. Thus, our findings establish a clear mechanism
    for auxin-induced pathogen susceptibility. Engineered Nkd1 variants with increased
    expression or increased EAR-mediated TPL/TPR binding trigger typical salicylic-acid-mediated
    defense reactions, leading to pathogen resistance. This implies that moderate
    binding of Nkd1 to TPL is a result of a balancing evolutionary selection process
    to enable TPL manipulation while avoiding host recognition.
acknowledgement: "The research leading to these results received funding from the
  European Research Council under the European Union Seventh Framework Programme ERC-2013-STG
  grant agreement \r\n335691; the Austrian Science Fund (FWF) P27818-B22,I 3033-B22;
  the Austrian Academy of Sciences (OEAW); and the Deutsche Forschungsgemeinschaft
  (DFG, German Research Foundation) under Germany’s Excellence Strategy - EXC 2070-390732324.\r\nWe
  would like to thank the GMI/IMBA/IMP core facilities for excellent technical support,
  especially the BioOptics and Molecular Biology Services. We thank the Plant Sciences
  and Next Generation Sequencing Facilities at the Vienna BioCenter Core Facilities
  GmbH (VBCF). We are grateful to the Jirí Friml and Jürgen Kleine-Vehn laboratories
  for providing useful A. thaliana lines. We thank Mathias Madalinski for peptide
  synthesis and Dr. J. Matthew Watson for proofreading and valuable feedback on the
  manuscript. The authors declare no competing interests."
article_number: '100269'
article_processing_charge: Yes
article_type: original
author:
- first_name: Fernando
  full_name: Navarrete, Fernando
  last_name: Navarrete
- first_name: Michelle C
  full_name: Gallei, Michelle C
  id: 35A03822-F248-11E8-B48F-1D18A9856A87
  last_name: Gallei
  orcid: 0000-0003-1286-7368
- first_name: Aleksandra E.
  full_name: Kornienko, Aleksandra E.
  last_name: Kornienko
- first_name: Indira
  full_name: Saado, Indira
  last_name: Saado
- first_name: Mamoona
  full_name: Khan, Mamoona
  last_name: Khan
- first_name: Khong-Sam
  full_name: Chia, Khong-Sam
  last_name: Chia
- first_name: Martin A.
  full_name: Darino, Martin A.
  last_name: Darino
- first_name: Janos
  full_name: Bindics, Janos
  last_name: Bindics
- first_name: Armin
  full_name: Djamei, Armin
  last_name: Djamei
citation:
  ama: Navarrete F, Gallei MC, Kornienko AE, et al. TOPLESS promotes plant immunity
    by repressing auxin signaling and is targeted by the fungal effector Naked1. <i>Plant
    Communications</i>. 2022;3(2). doi:<a href="https://doi.org/10.1016/j.xplc.2021.100269">10.1016/j.xplc.2021.100269</a>
  apa: Navarrete, F., Gallei, M. C., Kornienko, A. E., Saado, I., Khan, M., Chia,
    K.-S., … Djamei, A. (2022). TOPLESS promotes plant immunity by repressing auxin
    signaling and is targeted by the fungal effector Naked1. <i>Plant Communications</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.xplc.2021.100269">https://doi.org/10.1016/j.xplc.2021.100269</a>
  chicago: Navarrete, Fernando, Michelle C Gallei, Aleksandra E. Kornienko, Indira
    Saado, Mamoona Khan, Khong-Sam Chia, Martin A. Darino, Janos Bindics, and Armin
    Djamei. “TOPLESS Promotes Plant Immunity by Repressing Auxin Signaling and Is
    Targeted by the Fungal Effector Naked1.” <i>Plant Communications</i>. Elsevier,
    2022. <a href="https://doi.org/10.1016/j.xplc.2021.100269">https://doi.org/10.1016/j.xplc.2021.100269</a>.
  ieee: F. Navarrete <i>et al.</i>, “TOPLESS promotes plant immunity by repressing
    auxin signaling and is targeted by the fungal effector Naked1,” <i>Plant Communications</i>,
    vol. 3, no. 2. Elsevier, 2022.
  ista: Navarrete F, Gallei MC, Kornienko AE, Saado I, Khan M, Chia K-S, Darino MA,
    Bindics J, Djamei A. 2022. TOPLESS promotes plant immunity by repressing auxin
    signaling and is targeted by the fungal effector Naked1. Plant Communications.
    3(2), 100269.
  mla: Navarrete, Fernando, et al. “TOPLESS Promotes Plant Immunity by Repressing
    Auxin Signaling and Is Targeted by the Fungal Effector Naked1.” <i>Plant Communications</i>,
    vol. 3, no. 2, 100269, Elsevier, 2022, doi:<a href="https://doi.org/10.1016/j.xplc.2021.100269">10.1016/j.xplc.2021.100269</a>.
  short: F. Navarrete, M.C. Gallei, A.E. Kornienko, I. Saado, M. Khan, K.-S. Chia,
    M.A. Darino, J. Bindics, A. Djamei, Plant Communications 3 (2022).
date_created: 2024-05-29T06:10:22Z
date_published: 2022-03-14T00:00:00Z
date_updated: 2024-08-05T10:27:03Z
day: '14'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1016/j.xplc.2021.100269
external_id:
  pmid:
  - '35529945'
file:
- access_level: open_access
  checksum: 1eeb6ee65419e4aa34627fea6857f343
  content_type: application/pdf
  creator: dernst
  date_created: 2024-08-05T10:26:29Z
  date_updated: 2024-08-05T10:26:29Z
  file_id: '17393'
  file_name: 2022_PlantComm_Navarrete.pdf
  file_size: 3216686
  relation: main_file
  success: 1
file_date_updated: 2024-08-05T10:26:29Z
has_accepted_license: '1'
intvolume: '         3'
issue: '2'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
publication: Plant Communications
publication_identifier:
  issn:
  - 2590-3462
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: TOPLESS promotes plant immunity by repressing auxin signaling and is targeted
  by the fungal effector Naked1
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2022'
...
---
OA_place: repository
OA_type: green
_id: '17069'
abstract:
- lang: eng
  text: Fertilization of an egg by multiple sperm (polyspermy) leads to lethal genome
    imbalance and chromosome segregation defects. In Arabidopsis thaliana, the block
    to polyspermy is facilitated by a mechanism that prevents polytubey (the arrival
    of multiple pollen tubes to one ovule). We show here that FERONIA, ANJEA, and
    HERCULES RECEPTOR KINASE 1 receptor-like kinases located at the septum interact
    with pollen tube–specific RALF6, 7, 16, 36, and 37 peptide ligands to establish
    this polytubey block. The same combination of RALF (rapid alkalinization factor)
    peptides and receptor complexes controls pollen tube reception and rupture inside
    the targeted ovule. Pollen tube rupture releases the polytubey block at the septum,
    which allows the emergence of secondary pollen tubes upon fertilization failure.
    Thus, orchestrated steps in the fertilization process in Arabidopsis are coordinated
    by the same signaling components to guarantee and optimize reproductive success.
acknowledgement: "We thank D. Ye for providing fer-4 and myb97 myb101 myb120 mutant
  seeds; L. Smith for sharing anj, herk1, anj herk1, and fer anj herk1 mutant seeds;
  J. F. Harper for providing aca9 mutant seeds; and C. Li and Q. Duan for sharing
  fer+/− mutant seeds.\r\nL.-J.Q. was funded by the National Natural Science Foundation
  of China (grant nos. 31991202, 31830004, 31620103903, and 31621001), S.Z. was supported
  by the Young Elite Scientists Sponsorship Program by the China Association of Science
  and Technology (2019QNRC001), Z.G. was supported by a NSFC Young Scientists Fund
  (31900161), A.Y.C. was funded by the US Natural Science Foundation (IOS-1645854,
  MCB-1715764, and MCB-0955910), J.D. was funded by the National Institute of Health
  (R01GM109080), and T.D. was supported by the German Research Foundation DFG (SFB924)."
article_processing_charge: No
article_type: original
author:
- first_name: Sheng
  full_name: Zhong, Sheng
  last_name: Zhong
- first_name: Ling
  full_name: Li, Ling
  last_name: Li
- first_name: Zhijuan
  full_name: Wang, Zhijuan
  last_name: Wang
- first_name: Zengxiang
  full_name: Ge, Zengxiang
  id: f43371a3-09ff-11eb-8013-bd0c6a2f6de8
  last_name: Ge
  orcid: 0000-0001-9381-3577
- first_name: Qiyun
  full_name: Li, Qiyun
  last_name: Li
- first_name: Andrea
  full_name: Bleckmann, Andrea
  last_name: Bleckmann
- first_name: Jizong
  full_name: Wang, Jizong
  last_name: Wang
- first_name: Zihan
  full_name: Song, Zihan
  last_name: Song
- first_name: Yihao
  full_name: Shi, Yihao
  last_name: Shi
- first_name: Tianxu
  full_name: Liu, Tianxu
  last_name: Liu
- first_name: Luhan
  full_name: Li, Luhan
  last_name: Li
- first_name: Huabin
  full_name: Zhou, Huabin
  last_name: Zhou
- first_name: Yanyan
  full_name: Wang, Yanyan
  last_name: Wang
- first_name: Li
  full_name: Zhang, Li
  last_name: Zhang
- first_name: Hen-Ming
  full_name: Wu, Hen-Ming
  last_name: Wu
- first_name: Luhua
  full_name: Lai, Luhua
  last_name: Lai
- first_name: Hongya
  full_name: Gu, Hongya
  last_name: Gu
- first_name: Juan
  full_name: Dong, Juan
  last_name: Dong
- first_name: Alice Y.
  full_name: Cheung, Alice Y.
  last_name: Cheung
- first_name: Thomas
  full_name: Dresselhaus, Thomas
  last_name: Dresselhaus
- first_name: Li-Jia
  full_name: Qu, Li-Jia
  last_name: Qu
citation:
  ama: Zhong S, Li L, Wang Z, et al. RALF peptide signaling controls the polytubey
    block in Arabidopsis. <i>Science</i>. 2022;375(6578):290-296. doi:<a href="https://doi.org/10.1126/science.abl4683">10.1126/science.abl4683</a>
  apa: Zhong, S., Li, L., Wang, Z., Ge, Z., Li, Q., Bleckmann, A., … Qu, L.-J. (2022).
    RALF peptide signaling controls the polytubey block in Arabidopsis. <i>Science</i>.
    American Association for the Advancement of Science. <a href="https://doi.org/10.1126/science.abl4683">https://doi.org/10.1126/science.abl4683</a>
  chicago: Zhong, Sheng, Ling Li, Zhijuan Wang, Zengxiang Ge, Qiyun Li, Andrea Bleckmann,
    Jizong Wang, et al. “RALF Peptide Signaling Controls the Polytubey Block in Arabidopsis.”
    <i>Science</i>. American Association for the Advancement of Science, 2022. <a
    href="https://doi.org/10.1126/science.abl4683">https://doi.org/10.1126/science.abl4683</a>.
  ieee: S. Zhong <i>et al.</i>, “RALF peptide signaling controls the polytubey block
    in Arabidopsis,” <i>Science</i>, vol. 375, no. 6578. American Association for
    the Advancement of Science, pp. 290–296, 2022.
  ista: Zhong S, Li L, Wang Z, Ge Z, Li Q, Bleckmann A, Wang J, Song Z, Shi Y, Liu
    T, Li L, Zhou H, Wang Y, Zhang L, Wu H-M, Lai L, Gu H, Dong J, Cheung AY, Dresselhaus
    T, Qu L-J. 2022. RALF peptide signaling controls the polytubey block in Arabidopsis.
    Science. 375(6578), 290–296.
  mla: Zhong, Sheng, et al. “RALF Peptide Signaling Controls the Polytubey Block in
    Arabidopsis.” <i>Science</i>, vol. 375, no. 6578, American Association for the
    Advancement of Science, 2022, pp. 290–96, doi:<a href="https://doi.org/10.1126/science.abl4683">10.1126/science.abl4683</a>.
  short: S. Zhong, L. Li, Z. Wang, Z. Ge, Q. Li, A. Bleckmann, J. Wang, Z. Song, Y.
    Shi, T. Liu, L. Li, H. Zhou, Y. Wang, L. Zhang, H.-M. Wu, L. Lai, H. Gu, J. Dong,
    A.Y. Cheung, T. Dresselhaus, L.-J. Qu, Science 375 (2022) 290–296.
date_created: 2024-05-29T06:11:10Z
date_published: 2022-01-20T00:00:00Z
date_updated: 2025-04-24T11:39:46Z
day: '20'
department:
- _id: JiFr
doi: 10.1126/science.abl4683
external_id:
  pmid:
  - '35050671'
intvolume: '       375'
issue: '6578'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040003
month: '01'
oa: 1
oa_version: Submitted Version
page: 290-296
pmid: 1
publication: Science
publication_identifier:
  eissn:
  - 1095-9203
  issn:
  - 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: RALF peptide signaling controls the polytubey block in Arabidopsis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 375
year: '2022'
...
---
_id: '17070'
abstract:
- lang: eng
  text: We investigate the formation of magnetic Bose polaron, an impurity atom dressed
    by spin-wave excitations, in a one-dimensional spinor Bose gas. Within an effective
    potential model, the impurity is strongly confined by the host excitations which
    can even overcome the impurity-medium repulsion leading to a self-localized quasi-particle
    state. The phase diagram of the attractive and self-bound repulsive magnetic polaron,
    repulsive non-magnetic (Fröhlich-type) polaron and impurity-medium phase-separation
    regimes is explored with respect to the Rabi-coupling between the spin components,
    spin–spin interactions and impurity-medium coupling. The residue of such magnetic
    polarons decreases substantially in both strong attractive and repulsive branches
    with strong impurity-spin interactions, illustrating significant dressing of the
    impurity. The impurity can be used to probe and maneuver the spin polarization
    of the magnetic medium while suppressing ferromagnetic spin–spin correlations.
    It is shown that mean-field theory fails as the spinor gas approaches immiscibility
    since the generated spin-wave excitations are prominent. Our findings illustrate
    that impurities can be utilized to generate controllable spin–spin correlations
    and magnetic polaron states which can be realized with current cold atom setups.
article_number: '083030'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: S I
  full_name: Mistakidis, S I
  last_name: Mistakidis
- first_name: Georgios
  full_name: Koutentakis, Georgios
  id: d7b23d3a-9e21-11ec-b482-f76739596b95
  last_name: Koutentakis
- first_name: F
  full_name: Grusdt, F
  last_name: Grusdt
- first_name: P
  full_name: Schmelcher, P
  last_name: Schmelcher
- first_name: H R
  full_name: Sadeghpour, H R
  last_name: Sadeghpour
citation:
  ama: 'Mistakidis SI, Koutentakis G, Grusdt F, Schmelcher P, Sadeghpour HR. Inducing
    spin-order with an impurity: phase diagram of the magnetic Bose polaron. <i>New
    Journal of Physics</i>. 2022;24(8). doi:<a href="https://doi.org/10.1088/1367-2630/ac836c">10.1088/1367-2630/ac836c</a>'
  apa: 'Mistakidis, S. I., Koutentakis, G., Grusdt, F., Schmelcher, P., &#38; Sadeghpour,
    H. R. (2022). Inducing spin-order with an impurity: phase diagram of the magnetic
    Bose polaron. <i>New Journal of Physics</i>. IOP Publishing. <a href="https://doi.org/10.1088/1367-2630/ac836c">https://doi.org/10.1088/1367-2630/ac836c</a>'
  chicago: 'Mistakidis, S I, Georgios Koutentakis, F Grusdt, P Schmelcher, and H R
    Sadeghpour. “Inducing Spin-Order with an Impurity: Phase Diagram of the Magnetic
    Bose Polaron.” <i>New Journal of Physics</i>. IOP Publishing, 2022. <a href="https://doi.org/10.1088/1367-2630/ac836c">https://doi.org/10.1088/1367-2630/ac836c</a>.'
  ieee: 'S. I. Mistakidis, G. Koutentakis, F. Grusdt, P. Schmelcher, and H. R. Sadeghpour,
    “Inducing spin-order with an impurity: phase diagram of the magnetic Bose polaron,”
    <i>New Journal of Physics</i>, vol. 24, no. 8. IOP Publishing, 2022.'
  ista: 'Mistakidis SI, Koutentakis G, Grusdt F, Schmelcher P, Sadeghpour HR. 2022.
    Inducing spin-order with an impurity: phase diagram of the magnetic Bose polaron.
    New Journal of Physics. 24(8), 083030.'
  mla: 'Mistakidis, S. I., et al. “Inducing Spin-Order with an Impurity: Phase Diagram
    of the Magnetic Bose Polaron.” <i>New Journal of Physics</i>, vol. 24, no. 8,
    083030, IOP Publishing, 2022, doi:<a href="https://doi.org/10.1088/1367-2630/ac836c">10.1088/1367-2630/ac836c</a>.'
  short: S.I. Mistakidis, G. Koutentakis, F. Grusdt, P. Schmelcher, H.R. Sadeghpour,
    New Journal of Physics 24 (2022).
date_created: 2024-05-29T06:11:35Z
date_published: 2022-09-08T00:00:00Z
date_updated: 2024-07-31T12:14:55Z
day: '08'
ddc:
- '530'
department:
- _id: MiLe
doi: 10.1088/1367-2630/ac836c
external_id:
  arxiv:
  - '2204.10960'
file:
- access_level: open_access
  checksum: 85776a9d3abe163b33b322c8e346752a
  content_type: application/pdf
  creator: dernst
  date_created: 2024-07-31T12:13:16Z
  date_updated: 2024-07-31T12:13:16Z
  file_id: '17358'
  file_name: 2022_NewJournPhysics_Mistakidis.pdf
  file_size: 4201283
  relation: main_file
  success: 1
file_date_updated: 2024-07-31T12:13:16Z
has_accepted_license: '1'
intvolume: '        24'
issue: '8'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
publication: New Journal of Physics
publication_identifier:
  issn:
  - 1367-2630
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Inducing spin-order with an impurity: phase diagram of the magnetic Bose polaron'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 24
year: '2022'
...
