---
_id: '11449'
abstract:
- lang: eng
text: Mutations are acquired frequently, such that each cell's genome inscribes
its history of cell divisions. Common genomic alterations involve loss of heterozygosity
(LOH). LOH accumulates throughout the genome, offering large encoding capacity
for inferring cell lineage. Using only single-cell RNA sequencing (scRNA-seq)
of mouse brain cells, we found that LOH events spanning multiple genes are revealed
as tracts of monoallelically expressed, constitutionally heterozygous single-nucleotide
variants (SNVs). We simultaneously inferred cell lineage and marked developmental
time points based on X chromosome inactivation and the total number of LOH events
while identifying cell types from gene expression patterns. Our results are consistent
with progenitor cells giving rise to multiple cortical cell types through stereotyped
expansion and distinct waves of neurogenesis. This type of retrospective analysis
could be incorporated into scRNA-seq pipelines and, compared with experimental
approaches for determining lineage in model organisms, is applicable where genetic
engineering is prohibited, such as humans.
acknowledgement: D.J.A. thanks Wayne K. Potts, Alan R. Rogers, Kristen Hawkes, Ryk
Ward, and Jon Seger for inspiring a young undergraduate to apply evolutionary theory
to intraorganism development. Supported by the Paul G. Allen Frontiers Group (University
of Washington); NIH R00HG010152 (Dartmouth); and NÖ Forschung und Bildung n[f+b]
life science call grant (C13-002) and the European Research Council (ERC) under
the European Union’s Horizon 2020 research and innovation program 725780 LinPro
to S.H.
article_processing_charge: No
article_type: original
author:
- first_name: Donovan J.
full_name: Anderson, Donovan J.
last_name: Anderson
- first_name: Florian
full_name: Pauler, Florian
id: 48EA0138-F248-11E8-B48F-1D18A9856A87
last_name: Pauler
orcid: 0000-0002-7462-0048
- first_name: Aaron
full_name: Mckenna, Aaron
last_name: Mckenna
- first_name: Jay
full_name: Shendure, Jay
last_name: Shendure
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
- first_name: Marshall S.
full_name: Horwitz, Marshall S.
last_name: Horwitz
citation:
ama: Anderson DJ, Pauler F, Mckenna A, Shendure J, Hippenmeyer S, Horwitz MS. Simultaneous
brain cell type and lineage determined by scRNA-seq reveals stereotyped cortical
development. Cell Systems. 2022;13(6):438-453.e5. doi:10.1016/j.cels.2022.03.006
apa: Anderson, D. J., Pauler, F., Mckenna, A., Shendure, J., Hippenmeyer, S., &
Horwitz, M. S. (2022). Simultaneous brain cell type and lineage determined by
scRNA-seq reveals stereotyped cortical development. Cell Systems. Elsevier.
https://doi.org/10.1016/j.cels.2022.03.006
chicago: Anderson, Donovan J., Florian Pauler, Aaron Mckenna, Jay Shendure, Simon
Hippenmeyer, and Marshall S. Horwitz. “Simultaneous Brain Cell Type and Lineage
Determined by ScRNA-Seq Reveals Stereotyped Cortical Development.” Cell Systems.
Elsevier, 2022. https://doi.org/10.1016/j.cels.2022.03.006.
ieee: D. J. Anderson, F. Pauler, A. Mckenna, J. Shendure, S. Hippenmeyer, and M.
S. Horwitz, “Simultaneous brain cell type and lineage determined by scRNA-seq
reveals stereotyped cortical development,” Cell Systems, vol. 13, no. 6.
Elsevier, p. 438–453.e5, 2022.
ista: Anderson DJ, Pauler F, Mckenna A, Shendure J, Hippenmeyer S, Horwitz MS. 2022.
Simultaneous brain cell type and lineage determined by scRNA-seq reveals stereotyped
cortical development. Cell Systems. 13(6), 438–453.e5.
mla: Anderson, Donovan J., et al. “Simultaneous Brain Cell Type and Lineage Determined
by ScRNA-Seq Reveals Stereotyped Cortical Development.” Cell Systems, vol.
13, no. 6, Elsevier, 2022, p. 438–453.e5, doi:10.1016/j.cels.2022.03.006.
short: D.J. Anderson, F. Pauler, A. Mckenna, J. Shendure, S. Hippenmeyer, M.S. Horwitz,
Cell Systems 13 (2022) 438–453.e5.
date_created: 2022-06-19T22:01:57Z
date_published: 2022-06-15T00:00:00Z
date_updated: 2026-06-18T17:15:22Z
day: '15'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1016/j.cels.2022.03.006
ec_funded: 1
external_id:
isi:
- '000814124400002'
pmid:
- '35452605'
fulldoi: https://doi.org/10.1016/j.cels.2022.03.006
intvolume: ' 13'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.cels.2022.03.006
month: '06'
oa: 1
oa_version: Published Version
page: 438-453.e5
pmid: 1
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '725780'
name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
- _id: 25D92700-B435-11E9-9278-68D0E5697425
grant_number: LS13-002
name: Mapping Cell-Type Specificity of the Genomic Imprintome in the Brain
publication: Cell Systems
publication_identifier:
eissn:
- 2405-4720
issn:
- 2405-4712
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Simultaneous brain cell type and lineage determined by scRNA-seq reveals stereotyped
cortical development
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2022'
...
---
_id: '11456'
abstract:
- lang: eng
text: The proteomes of specialized structures, and the interactomes of proteins
of interest, provide entry points to elucidate the functions of molecular machines.
Here, we review a proximity-labeling strategy that uses the improved E. coli biotin
ligase TurboID to characterize C. elegans protein complexes. Although the focus
is on C. elegans neurons, the method is applicable regardless of cell type. We
describe detailed extraction procedures that solubilize the bulk of C. elegans
proteins and highlight the importance of tagging endogenous genes, to ensure physiological
expression levels. We review issues associated with non-specific background noise
and the importance of appropriate controls. As proof of principle, we review our
analysis of the interactome of a presynaptic active zone protein, ELKS-1. Our
aim is to provide a detailed protocol for TurboID-based proximity labeling in
C. elegans and to highlight its potential and its limitations to characterize
protein complexes and subcellular compartments in this animal.
acknowledgement: We thank de Bono lab members for the helpful comments on the manuscript.
The biotin-auxotrophic E. coli strain MG1655bioB:kan was a generous gift from J.
Cronan (University of Illinois) and was kindly sent to us by Jessica Feldman and
Ariana Sanchez (Stanford University). dg398 pEntryslot2_mNeongreen::3XFLAG::stop
and dg397 pEntryslot3_mNeongreen::3XFLAG::stop::unc-54 3’UTR entry vector were kindly
sent by Dr. Dominique Glauser (University of Fribourg). This work was supported
by an Advanced ERC Grant (269058 ACMO) and a Wellcome Investigator Award (209504/Z/17/Z)
to MdB and an ISTplus Fellowship to MA (Marie Sklodowska-Curie agreement No 754411).
alternative_title:
- Neuromethods
article_processing_charge: No
author:
- first_name: Murat
full_name: Artan, Murat
id: C407B586-6052-11E9-B3AE-7006E6697425
last_name: Artan
orcid: 0000-0001-8945-6992
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
citation:
ama: 'Artan M, de Bono M. Proteomic Analysis of C. Elegans Neurons Using TurboID-Based
Proximity Labeling. In: Yamamoto D, ed. Behavioral Neurogenetics. Vol 181.
NM. New York: Springer Nature; 2022:277-294. doi:10.1007/978-1-0716-2321-3_15'
apa: 'Artan, M., & de Bono, M. (2022). Proteomic Analysis of C. Elegans Neurons
Using TurboID-Based Proximity Labeling. In D. Yamamoto (Ed.), Behavioral Neurogenetics
(Vol. 181, pp. 277–294). New York: Springer Nature. https://doi.org/10.1007/978-1-0716-2321-3_15'
chicago: 'Artan, Murat, and Mario de Bono. “Proteomic Analysis of C. Elegans Neurons
Using TurboID-Based Proximity Labeling.” In Behavioral Neurogenetics, edited
by Daisuke Yamamoto, 181:277–94. NM. New York: Springer Nature, 2022. https://doi.org/10.1007/978-1-0716-2321-3_15.'
ieee: 'M. Artan and M. de Bono, “Proteomic Analysis of C. Elegans Neurons Using
TurboID-Based Proximity Labeling,” in Behavioral Neurogenetics, vol. 181,
D. Yamamoto, Ed. New York: Springer Nature, 2022, pp. 277–294.'
ista: 'Artan M, de Bono M. 2022.Proteomic Analysis of C. Elegans Neurons Using TurboID-Based
Proximity Labeling. In: Behavioral Neurogenetics. Neuromethods, vol. 181, 277–294.'
mla: Artan, Murat, and Mario de Bono. “Proteomic Analysis of C. Elegans Neurons
Using TurboID-Based Proximity Labeling.” Behavioral Neurogenetics, edited
by Daisuke Yamamoto, vol. 181, Springer Nature, 2022, pp. 277–94, doi:10.1007/978-1-0716-2321-3_15.
short: M. Artan, M. de Bono, in:, D. Yamamoto (Ed.), Behavioral Neurogenetics, Springer
Nature, New York, 2022, pp. 277–294.
corr_author: '1'
date_created: 2022-06-20T08:10:34Z
date_published: 2022-06-04T00:00:00Z
date_updated: 2025-04-14T07:43:58Z
day: '04'
department:
- _id: MaDe
doi: 10.1007/978-1-0716-2321-3_15
ec_funded: 1
editor:
- first_name: Daisuke
full_name: Yamamoto, Daisuke
last_name: Yamamoto
fulldoi: https://doi.org/10.1007/978-1-0716-2321-3_15
intvolume: ' 181'
language:
- iso: eng
month: '06'
oa_version: None
page: 277-294
place: New York
project:
- _id: 23870BE8-32DE-11EA-91FC-C7463DDC885E
grant_number: 209504/A/17/Z
name: Molecular mechanisms of neural circuit function
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Behavioral Neurogenetics
publication_identifier:
eisbn:
- '9781071623213'
eissn:
- 1940-6045
isbn:
- '9781071623206'
issn:
- 0893-2336
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
series_title: NM
status: public
title: Proteomic Analysis of C. Elegans Neurons Using TurboID-Based Proximity Labeling
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 181
year: '2022'
...
---
_id: '11459'
abstract:
- lang: eng
text: 'We present a novel approach to differential cost analysis that, given a program
revision, attempts to statically bound the difference in resource usage, or cost,
between the two program versions. Differential cost analysis is particularly interesting
because of the many compelling applications for it, such as detecting resource-use
regressions at code-review time or proving the absence of certain side-channel
vulnerabilities. One prior approach to differential cost analysis is to apply
relational reasoning that conceptually constructs a product program on which one
can over-approximate the difference in costs between the two program versions.
However, a significant challenge in any relational approach is effectively aligning
the program versions to get precise results. In this paper, our key insight is
that we can avoid the need for and the limitations of program alignment if, instead,
we bound the difference of two cost-bound summaries rather than directly bounding
the concrete cost difference. In particular, our method computes a threshold value
for the maximal difference in cost between two program versions simultaneously
using two kinds of cost-bound summaries---a potential function that evaluates
to an upper bound for the cost incurred in the first program and an anti-potential
function that evaluates to a lower bound for the cost incurred in the second.
Our method has a number of desirable properties: it can be fully automated, it
allows optimizing the threshold value on relative cost, it is suitable for programs
that are not syntactically similar, and it supports non-determinism. We have evaluated
an implementation of our approach on a number of program pairs collected from
the literature, and we find that our method computes tight threshold values on
relative cost in most examples.'
acknowledgement: "We thank Shaun Willows, Thomas Lugnet, and the Living Room Application
Vending team for suggesting threshold\r\nbounds as a developer-friendly way to interact
with a differential cost analyzer, and we thank Jim Christy, Daniel\r\nSchoepe,
and the Prime Video Automated Reasoning team for their support and helpful suggestions
throughout the\r\nproject. We also thank Michael Emmi for feedback on an earlier
version of this paper. And finally, we thank the anonymous reviewers for their useful
feedback and Aws Albarghouthi for shepherding the final version of the paper. Ðorđe
Žikelić was also partially supported by ERC CoG 863818 (FoRM-SMArt)."
article_processing_charge: No
arxiv: 1
author:
- first_name: Dorde
full_name: Zikelic, Dorde
id: 294AA7A6-F248-11E8-B48F-1D18A9856A87
last_name: Zikelic
orcid: 0000-0002-4681-1699
- first_name: Bor-Yuh Evan
full_name: Chang, Bor-Yuh Evan
last_name: Chang
- first_name: Pauline
full_name: Bolignano, Pauline
last_name: Bolignano
- first_name: Franco
full_name: Raimondi, Franco
last_name: Raimondi
citation:
ama: 'Zikelic D, Chang B-YE, Bolignano P, Raimondi F. Differential cost analysis
with simultaneous potentials and anti-potentials. In: Proceedings of the 43rd
ACM SIGPLAN International Conference on Programming Language Design and Implementation.
Association for Computing Machinery; 2022:442-457. doi:10.1145/3519939.3523435'
apa: 'Zikelic, D., Chang, B.-Y. E., Bolignano, P., & Raimondi, F. (2022). Differential
cost analysis with simultaneous potentials and anti-potentials. In Proceedings
of the 43rd ACM SIGPLAN International Conference on Programming Language Design
and Implementation (pp. 442–457). San Diego, CA, United States: Association
for Computing Machinery. https://doi.org/10.1145/3519939.3523435'
chicago: Zikelic, Dorde, Bor-Yuh Evan Chang, Pauline Bolignano, and Franco Raimondi.
“Differential Cost Analysis with Simultaneous Potentials and Anti-Potentials.”
In Proceedings of the 43rd ACM SIGPLAN International Conference on Programming
Language Design and Implementation, 442–57. Association for Computing Machinery,
2022. https://doi.org/10.1145/3519939.3523435.
ieee: D. Zikelic, B.-Y. E. Chang, P. Bolignano, and F. Raimondi, “Differential cost
analysis with simultaneous potentials and anti-potentials,” in Proceedings
of the 43rd ACM SIGPLAN International Conference on Programming Language Design
and Implementation, San Diego, CA, United States, 2022, pp. 442–457.
ista: 'Zikelic D, Chang B-YE, Bolignano P, Raimondi F. 2022. Differential cost analysis
with simultaneous potentials and anti-potentials. Proceedings of the 43rd ACM
SIGPLAN International Conference on Programming Language Design and Implementation.
PLDI: Programming Language Design and Implementation, 442–457.'
mla: Zikelic, Dorde, et al. “Differential Cost Analysis with Simultaneous Potentials
and Anti-Potentials.” Proceedings of the 43rd ACM SIGPLAN International Conference
on Programming Language Design and Implementation, Association for Computing
Machinery, 2022, pp. 442–57, doi:10.1145/3519939.3523435.
short: D. Zikelic, B.-Y.E. Chang, P. Bolignano, F. Raimondi, in:, Proceedings of
the 43rd ACM SIGPLAN International Conference on Programming Language Design and
Implementation, Association for Computing Machinery, 2022, pp. 442–457.
conference:
end_date: 2022-06-17
location: San Diego, CA, United States
name: 'PLDI: Programming Language Design and Implementation'
start_date: 2022-06-13
corr_author: '1'
date_created: 2022-06-21T09:26:15Z
date_published: 2022-06-09T00:00:00Z
date_updated: 2025-04-14T07:52:47Z
day: '09'
ddc:
- '000'
department:
- _id: GradSch
- _id: KrCh
doi: 10.1145/3519939.3523435
ec_funded: 1
external_id:
arxiv:
- '2204.00870'
isi:
- '000850435600030'
file:
- access_level: open_access
checksum: 7eb915a2ca5b5ce4729321f33b2e16e1
content_type: application/pdf
creator: dernst
date_created: 2022-06-27T07:38:21Z
date_updated: 2022-06-27T07:38:21Z
file_id: '11466'
file_name: 2022_PLDI_Zikelic.pdf
file_size: 318697
relation: main_file
success: 1
file_date_updated: 2022-06-27T07:38:21Z
fulldoi: https://doi.org/10.1145/3519939.3523435
has_accepted_license: '1'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '06'
oa: 1
oa_version: Published Version
page: 442-457
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '863818'
name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
publication: Proceedings of the 43rd ACM SIGPLAN International Conference on Programming
Language Design and Implementation
publication_identifier:
isbn:
- '9781450392655'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential cost analysis with simultaneous potentials and anti-potentials
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
year: '2022'
...
---
_id: '11460'
abstract:
- lang: eng
text: "Background: Proper cerebral cortical development depends on the tightly orchestrated
migration of newly born neurons from the inner ventricular and subventricular
zones to the outer cortical plate. Any disturbance in this process during prenatal
stages may lead to neuronal migration disorders (NMDs), which can vary in extent
from focal to global. Furthermore, NMDs show a substantial comorbidity with other
neurodevelopmental disorders, notably autism spectrum disorders (ASDs). Our previous
work demonstrated focal neuronal migration defects in mice carrying loss-of-function
alleles of the recognized autism risk gene WDFY3. However, the cellular origins
of these defects in Wdfy3 mutant mice remain elusive and uncovering it will provide
critical insight into WDFY3-dependent disease pathology.\r\nMethods: Here, in
an effort to untangle the origins of NMDs in Wdfy3lacZ mice, we employed mosaic
analysis with double markers (MADM). MADM technology enabled us to genetically
distinctly track and phenotypically analyze mutant and wild-type cells concomitantly
in vivo using immunofluorescent techniques.\r\nResults: We revealed a cell autonomous
requirement of WDFY3 for accurate laminar positioning of cortical projection neurons
and elimination of mispositioned cells during early postnatal life. In addition,
we identified significant deviations in dendritic arborization, as well as synaptic
density and morphology between wild type, heterozygous, and homozygous Wdfy3 mutant
neurons in Wdfy3-MADM reporter mice at postnatal stages.\r\nLimitations: While
Wdfy3 mutant mice have provided valuable insight into prenatal aspects of ASD
pathology that remain inaccessible to investigation in humans, like most animal
models, they do not a perfectly replicate all aspects of human ASD biology. The
lack of human data makes it indeterminate whether morphological deviations described
here apply to ASD patients or some of the other neurodevelopmental conditions
associated with WDFY3 mutation.\r\nConclusions: Our genetic approach revealed
several cell autonomous requirements of WDFY3 in neuronal development that could
underlie the pathogenic mechanisms of WDFY3-related neurodevelopmental conditions.
The results are also consistent with findings in other ASD animal models and patients
and suggest an important role for WDFY3 in regulating neuronal function and interconnectivity
in postnatal life."
acknowledgement: "This study was funded by NIMH R21MH115347 to KSZ. KSZ is further
supported by Shriners Hospitals for Children.\r\nWe would like to thank Angelo Harlan
de Crescenzo for early contributions to this project."
article_number: '27'
article_processing_charge: No
article_type: original
author:
- first_name: Zachary A.
full_name: Schaaf, Zachary A.
last_name: Schaaf
- first_name: Lyvin
full_name: Tat, Lyvin
last_name: Tat
- first_name: Noemi
full_name: Cannizzaro, Noemi
last_name: Cannizzaro
- first_name: Ralph
full_name: Green, Ralph
last_name: Green
- first_name: Thomas
full_name: Rülicke, Thomas
last_name: Rülicke
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
- first_name: Konstantinos S.
full_name: Zarbalis, Konstantinos S.
last_name: Zarbalis
citation:
ama: Schaaf ZA, Tat L, Cannizzaro N, et al. WDFY3 mutation alters laminar position
and morphology of cortical neurons. Molecular Autism. 2022;13. doi:10.1186/s13229-022-00508-3
apa: Schaaf, Z. A., Tat, L., Cannizzaro, N., Green, R., Rülicke, T., Hippenmeyer,
S., & Zarbalis, K. S. (2022). WDFY3 mutation alters laminar position and morphology
of cortical neurons. Molecular Autism. Springer Nature. https://doi.org/10.1186/s13229-022-00508-3
chicago: Schaaf, Zachary A., Lyvin Tat, Noemi Cannizzaro, Ralph Green, Thomas Rülicke,
Simon Hippenmeyer, and Konstantinos S. Zarbalis. “WDFY3 Mutation Alters Laminar
Position and Morphology of Cortical Neurons.” Molecular Autism. Springer
Nature, 2022. https://doi.org/10.1186/s13229-022-00508-3.
ieee: Z. A. Schaaf et al., “WDFY3 mutation alters laminar position and morphology
of cortical neurons,” Molecular Autism, vol. 13. Springer Nature, 2022.
ista: Schaaf ZA, Tat L, Cannizzaro N, Green R, Rülicke T, Hippenmeyer S, Zarbalis
KS. 2022. WDFY3 mutation alters laminar position and morphology of cortical neurons.
Molecular Autism. 13, 27.
mla: Schaaf, Zachary A., et al. “WDFY3 Mutation Alters Laminar Position and Morphology
of Cortical Neurons.” Molecular Autism, vol. 13, 27, Springer Nature, 2022,
doi:10.1186/s13229-022-00508-3.
short: Z.A. Schaaf, L. Tat, N. Cannizzaro, R. Green, T. Rülicke, S. Hippenmeyer,
K.S. Zarbalis, Molecular Autism 13 (2022).
date_created: 2022-06-23T14:28:55Z
date_published: 2022-06-22T00:00:00Z
date_updated: 2025-06-11T13:34:57Z
day: '22'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1186/s13229-022-00508-3
external_id:
isi:
- '000814641400001'
pmid:
- '35733184'
file:
- access_level: open_access
checksum: 525d2618e855139089bbfc3e3d49d1b2
content_type: application/pdf
creator: dernst
date_created: 2022-06-24T08:22:59Z
date_updated: 2022-06-24T08:22:59Z
file_id: '11461'
file_name: 2022_MolecularAutism_Schaaf.pdf
file_size: 7552298
relation: main_file
success: 1
file_date_updated: 2022-06-24T08:22:59Z
fulldoi: https://doi.org/10.1186/s13229-022-00508-3
has_accepted_license: '1'
intvolume: ' 13'
isi: 1
keyword:
- Psychiatry and Mental health
- Developmental Biology
- Developmental Neuroscience
- Molecular Biology
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
publication: Molecular Autism
publication_identifier:
issn:
- 2040-2392
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1186/s13229-023-00539-4
scopus_import: '1'
status: public
title: WDFY3 mutation alters laminar position and morphology of cortical neurons
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2022'
...
---
_id: '11462'
abstract:
- lang: eng
text: Nanobodies (VHH) from camelid antibody libraries hold great promise as therapeutic
agents and components of immunoassay systems. Synthetic antibody libraries that
could be designed and generated once and for various applications could yield
binders to virtually any targets, even for non-immunogenic or toxic ones, in a
short term. One of the most difficult tasks is to obtain antibodies with a high
affinity and specificity to polyglycosylated proteins. It requires antibody libraries
with extremely high functional diversity and the use of sophisticated selection
techniques. Here we report a development of a novel sandwich immunoassay involving
a combination of the synthetic library-derived VHH-Fc fusion protein as a capture
antibody and the immune single-chain fragment variable (scFv) as a tracer for
the detection of pregnancy-associated glycoprotein (PAG) of cattle (Bos taurus).
We succeeded in the generation of a number of specific scFv antibodies against
PAG from the mouse immune library. Subsequent selection using the immobilized
scFv-Fc capture antibody allowed to isolate 1.9 nM VHH binder from the diverse
synthetic library without any overlapping with the capture antibody binding site.
The prototype sandwich ELISA based on the synthetic VHH and the immune scFv was
established. This is the first successful example of the combination of synthetic
and immune antibody libraries in a single sandwich immunoassay. Thus, our approach
could be used for the express isolation of antibody pairs and the development
of sandwich immunoassays for challenging antigens.
acknowledgement: This study was financially supported by the State Committee on Science
and Technology. We would like to thank Elena Tumar and Elena Kisileva at the Institute
of Bioorganic Chemistry of NASB for their kind assistance with mouse immunizations.
article_processing_charge: No
article_type: original
author:
- first_name: Dmitri
full_name: Dormeshkin, Dmitri
last_name: Dormeshkin
- first_name: Michail
full_name: Shapira, Michail
last_name: Shapira
- first_name: Alena
full_name: Karputs, Alena
last_name: Karputs
- first_name: Anton
full_name: Kavaleuski, Anton
id: 62304f89-eb97-11eb-a6c2-8903dd183976
last_name: Kavaleuski
orcid: 0000-0003-2091-526X
- first_name: Ivan
full_name: Kuzminski, Ivan
last_name: Kuzminski
- first_name: Elena
full_name: Stepanova, Elena
last_name: Stepanova
- first_name: Andrei
full_name: Gilep, Andrei
last_name: Gilep
citation:
ama: Dormeshkin D, Shapira M, Karputs A, et al. Combining of synthetic VHH and immune
scFv libraries for pregnancy-associated glycoproteins ELISA development. Applied
Microbiology and Biotechnology. 2022;106:5093-5103. doi:10.1007/s00253-022-12022-w
apa: Dormeshkin, D., Shapira, M., Karputs, A., Kavaleuski, A., Kuzminski, I., Stepanova,
E., & Gilep, A. (2022). Combining of synthetic VHH and immune scFv libraries
for pregnancy-associated glycoproteins ELISA development. Applied Microbiology
and Biotechnology. Springer Nature. https://doi.org/10.1007/s00253-022-12022-w
chicago: Dormeshkin, Dmitri, Michail Shapira, Alena Karputs, Anton Kavaleuski, Ivan
Kuzminski, Elena Stepanova, and Andrei Gilep. “Combining of Synthetic VHH and
Immune ScFv Libraries for Pregnancy-Associated Glycoproteins ELISA Development.”
Applied Microbiology and Biotechnology. Springer Nature, 2022. https://doi.org/10.1007/s00253-022-12022-w.
ieee: D. Dormeshkin et al., “Combining of synthetic VHH and immune scFv libraries
for pregnancy-associated glycoproteins ELISA development,” Applied Microbiology
and Biotechnology, vol. 106. Springer Nature, pp. 5093–5103, 2022.
ista: Dormeshkin D, Shapira M, Karputs A, Kavaleuski A, Kuzminski I, Stepanova E,
Gilep A. 2022. Combining of synthetic VHH and immune scFv libraries for pregnancy-associated
glycoproteins ELISA development. Applied Microbiology and Biotechnology. 106,
5093–5103.
mla: Dormeshkin, Dmitri, et al. “Combining of Synthetic VHH and Immune ScFv Libraries
for Pregnancy-Associated Glycoproteins ELISA Development.” Applied Microbiology
and Biotechnology, vol. 106, Springer Nature, 2022, pp. 5093–103, doi:10.1007/s00253-022-12022-w.
short: D. Dormeshkin, M. Shapira, A. Karputs, A. Kavaleuski, I. Kuzminski, E. Stepanova,
A. Gilep, Applied Microbiology and Biotechnology 106 (2022) 5093–5103.
date_created: 2022-06-26T22:01:34Z
date_published: 2022-08-01T00:00:00Z
date_updated: 2023-10-10T07:15:02Z
day: '01'
department:
- _id: GradSch
- _id: LeSa
doi: 10.1007/s00253-022-12022-w
external_id:
isi:
- '000813677500001'
pmid:
- '35723693'
fulldoi: https://doi.org/10.1007/s00253-022-12022-w
intvolume: ' 106'
isi: 1
language:
- iso: eng
month: '08'
oa_version: None
page: 5093-5103
pmid: 1
publication: Applied Microbiology and Biotechnology
publication_identifier:
eissn:
- 1432-0614
issn:
- 0175-7598
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Combining of synthetic VHH and immune scFv libraries for pregnancy-associated
glycoproteins ELISA development
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 106
year: '2022'
...
---
_id: '11469'
abstract:
- lang: eng
text: Thermalizing and localized many-body quantum systems present two distinct
dynamical phases of matter. Recently the fate of a localized system coupled to
a thermalizing system viewed as a quantum bath received significant theoretical
and experimental attention. In this work, we study a mobile impurity, representing
a small quantum bath, that interacts locally with an Anderson insulator with a
finite density of localized particles. Using static Hartree approximation to obtain
an effective disorder strength, we formulate an analytic criterion for the perturbative
stability of the localization. Next, we use an approximate dynamical Hartree method
and the quasi-exact time-evolved block decimation (TEBD) algorithm to study the
dynamics of the system. We find that the dynamical Hartree approach which completely
ignores entanglement between the impurity and localized particles predicts the
delocalization of the system. In contrast, the full numerical simulation of the
unitary dynamics with TEBD suggests the stability of localization on numerically
accessible timescales. Finally, using an extension of the density matrix renormalization
group algorithm to excited states (DMRG-X), we approximate the highly excited
eigenstates of the system. We find that the impurity remains localized in the
eigenstates and entanglement is enhanced in a finite region around the position
of the impurity, confirming the dynamical predictions. Dynamics and the DMRG-X
results provide compelling evidence for the stability of localization.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: We thank M. Ljubotina for insightful discussions. P. B., A. M. and
M. S. acknowledge support by the European Research Council (ERC) under the European
Union’s Horizon 2020 research and innovation program (Grant Agreement No. 850899).
D. A. was supported by the Swiss National Science Foundation and by the European
Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
program (Grant Agreement No. 864597). The development of parallel TEBD code was
supported by S. Elefante from the Scientific Computing (SciComp) that is part of
Scientific Service Units (SSU) of IST Austria. Some of the computations were performed
on the Baobab cluster of the University of Geneva.
article_number: '224208'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Pietro
full_name: Brighi, Pietro
id: 4115AF5C-F248-11E8-B48F-1D18A9856A87
last_name: Brighi
orcid: 0000-0002-7969-2729
- first_name: Alexios
full_name: Michailidis, Alexios
id: 36EBAD38-F248-11E8-B48F-1D18A9856A87
last_name: Michailidis
orcid: 0000-0002-8443-1064
- first_name: Kristina
full_name: Kirova, Kristina
id: 4aeda2ae-f847-11ec-98e0-c4a66fe174d4
last_name: Kirova
- first_name: Dmitry A.
full_name: Abanin, Dmitry A.
last_name: Abanin
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
citation:
ama: Brighi P, Michailidis A, Kirova K, Abanin DA, Serbyn M. Localization of a mobile
impurity interacting with an Anderson insulator. Physical Review B. 2022;105(22).
doi:10.1103/physrevb.105.224208
apa: Brighi, P., Michailidis, A., Kirova, K., Abanin, D. A., & Serbyn, M. (2022).
Localization of a mobile impurity interacting with an Anderson insulator. Physical
Review B. American Physical Society. https://doi.org/10.1103/physrevb.105.224208
chicago: Brighi, Pietro, Alexios Michailidis, Kristina Kirova, Dmitry A. Abanin,
and Maksym Serbyn. “Localization of a Mobile Impurity Interacting with an Anderson
Insulator.” Physical Review B. American Physical Society, 2022. https://doi.org/10.1103/physrevb.105.224208.
ieee: P. Brighi, A. Michailidis, K. Kirova, D. A. Abanin, and M. Serbyn, “Localization
of a mobile impurity interacting with an Anderson insulator,” Physical Review
B, vol. 105, no. 22. American Physical Society, 2022.
ista: Brighi P, Michailidis A, Kirova K, Abanin DA, Serbyn M. 2022. Localization
of a mobile impurity interacting with an Anderson insulator. Physical Review B.
105(22), 224208.
mla: Brighi, Pietro, et al. “Localization of a Mobile Impurity Interacting with
an Anderson Insulator.” Physical Review B, vol. 105, no. 22, 224208, American
Physical Society, 2022, doi:10.1103/physrevb.105.224208.
short: P. Brighi, A. Michailidis, K. Kirova, D.A. Abanin, M. Serbyn, Physical Review
B 105 (2022).
corr_author: '1'
date_created: 2022-06-29T20:19:51Z
date_published: 2022-06-27T00:00:00Z
date_updated: 2026-04-07T13:26:31Z
day: '27'
department:
- _id: MaSe
doi: 10.1103/physrevb.105.224208
ec_funded: 1
external_id:
arxiv:
- '2111.08603'
isi:
- '000823050000001'
fulldoi: https://doi.org/10.1103/physrevb.105.224208
intvolume: ' 105'
isi: 1
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.48550/arXiv.2111.08603'
month: '06'
oa: 1
oa_version: Preprint
project:
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '850899'
name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication: Physical Review B
publication_identifier:
eissn:
- 2469-9969
issn:
- 2469-9950
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
record:
- id: '12732'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Localization of a mobile impurity interacting with an Anderson insulator
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 105
year: '2022'
...
---
_id: '11470'
abstract:
- lang: eng
text: Many-body localization (MBL) is an example of a dynamical phase of matter
that avoids thermalization. While the MBL phase is robust to weak local perturbations,
the fate of an MBL system coupled to a thermalizing quantum system that represents
a “heat bath” is an open question that is actively investigated theoretically
and experimentally. In this work, we consider the stability of an Anderson insulator
with a finite density of particles interacting with a single mobile impurity—a
small quantum bath. We give perturbative arguments that support the stability
of localization in the strong interaction regime. Large-scale tensor network simulations
of dynamics are employed to corroborate the presence of the localized phase and
give quantitative predictions in the thermodynamic limit. We develop a phenomenological
description of the dynamics in the strong interaction regime, and we demonstrate
that the impurity effectively turns the Anderson insulator into an MBL phase,
giving rise to nontrivial entanglement dynamics well captured by our phenomenology.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: We acknowledge useful discussions with M. Ljubotina. P. B., A. M.,
and M. S. were supported by the European Research Council (ERC) under the European
Union’s Horizon 2020 research and innovation program (Grant Agreement No. 850899).
D.A. was supported by the Swiss National Science Foundation and by the European
Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
program (Grant Agreement No. 864597). The development of parallel TEBD code was
was supported by S. Elefante from the Scientific Computing (SciComp) that is part
of Scientific Service Units (SSU) of IST Austria. Some of the computations were
performed on the Baobab cluster of the University of Geneva.
article_number: L220203
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Pietro
full_name: Brighi, Pietro
id: 4115AF5C-F248-11E8-B48F-1D18A9856A87
last_name: Brighi
orcid: 0000-0002-7969-2729
- first_name: Alexios A.
full_name: Michailidis, Alexios A.
last_name: Michailidis
- first_name: Dmitry A.
full_name: Abanin, Dmitry A.
last_name: Abanin
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
citation:
ama: Brighi P, Michailidis AA, Abanin DA, Serbyn M. Propagation of many-body localization
in an Anderson insulator. Physical Review B. 2022;105(22). doi:10.1103/physrevb.105.l220203
apa: Brighi, P., Michailidis, A. A., Abanin, D. A., & Serbyn, M. (2022). Propagation
of many-body localization in an Anderson insulator. Physical Review B.
American Physical Society. https://doi.org/10.1103/physrevb.105.l220203
chicago: Brighi, Pietro, Alexios A. Michailidis, Dmitry A. Abanin, and Maksym Serbyn.
“Propagation of Many-Body Localization in an Anderson Insulator.” Physical
Review B. American Physical Society, 2022. https://doi.org/10.1103/physrevb.105.l220203.
ieee: P. Brighi, A. A. Michailidis, D. A. Abanin, and M. Serbyn, “Propagation of
many-body localization in an Anderson insulator,” Physical Review B, vol.
105, no. 22. American Physical Society, 2022.
ista: Brighi P, Michailidis AA, Abanin DA, Serbyn M. 2022. Propagation of many-body
localization in an Anderson insulator. Physical Review B. 105(22), L220203.
mla: Brighi, Pietro, et al. “Propagation of Many-Body Localization in an Anderson
Insulator.” Physical Review B, vol. 105, no. 22, L220203, American Physical
Society, 2022, doi:10.1103/physrevb.105.l220203.
short: P. Brighi, A.A. Michailidis, D.A. Abanin, M. Serbyn, Physical Review B 105
(2022).
corr_author: '1'
date_created: 2022-06-29T20:20:47Z
date_published: 2022-06-27T00:00:00Z
date_updated: 2026-04-07T13:26:31Z
day: '27'
department:
- _id: MaSe
doi: 10.1103/physrevb.105.l220203
ec_funded: 1
external_id:
arxiv:
- '2109.07332'
isi:
- '000823050000012'
fulldoi: https://doi.org/10.1103/physrevb.105.l220203
intvolume: ' 105'
isi: 1
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.48550/arXiv.2109.07332'
month: '06'
oa: 1
oa_version: Preprint
project:
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '850899'
name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication: Physical Review B
publication_identifier:
eissn:
- 2469-9969
issn:
- 2469-9950
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
record:
- id: '12732'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Propagation of many-body localization in an Anderson insulator
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 105
year: '2022'
...
---
OA_place: publisher
_id: '11473'
abstract:
- lang: eng
text: "The polaron model is a basic model of quantum field theory describing a single
particle\r\ninteracting with a bosonic field. It arises in many physical contexts.
We are mostly concerned\r\nwith models applicable in the context of an impurity
atom in a Bose-Einstein condensate as\r\nwell as the problem of electrons moving
in polar crystals.\r\nThe model has a simple structure in which the interaction
of the particle with the field is given\r\nby a term linear in the field’s creation
and annihilation operators. In this work, we investigate\r\nthe properties of
this model by providing rigorous estimates on various energies relevant to the\r\nproblem.
The estimates are obtained, for the most part, by suitable operator techniques
which\r\nconstitute the principal mathematical substance of the thesis.\r\nThe
first application of these techniques is to derive the polaron model rigorously
from first\r\nprinciples, i.e., from a full microscopic quantum-mechanical many-body
problem involving an\r\nimpurity in an otherwise homogeneous system. We accomplish
this for the N + 1 Bose gas\r\nin the mean-field regime by showing that a suitable
polaron-type Hamiltonian arises at weak\r\ninteractions as a low-energy effective
theory for this problem.\r\nIn the second part, we investigate rigorously the
ground state of the model at fixed momentum\r\nand for large values of the coupling
constant. Qualitatively, the system is expected to display\r\na transition from
the quasi-particle behavior at small momenta, where the dispersion relation\r\nis
parabolic and the particle moves through the medium dragging along a cloud of
phonons, to\r\nthe radiative behavior at larger momenta where the polaron decelerates
and emits free phonons.\r\nAt the same time, in the strong coupling regime, the
bosonic field is expected to behave purely\r\nclassically. Accordingly, the effective
mass of the polaron at strong coupling is conjectured to\r\nbe asymptotically
equal to the one obtained from the semiclassical counterpart of the problem,\r\nfirst
studied by Landau and Pekar in the 1940s. For polaron models with regularized
form\r\nfactors and phonon dispersion relations of superfluid type, i.e., bounded
below by a linear\r\nfunction of the wavenumbers for all phonon momenta as in
the interacting Bose gas, we prove\r\nthat for a large window of momenta below
the radiation threshold, the energy-momentum\r\nrelation at strong coupling is
indeed essentially a parabola with semi-latus rectum equal to the\r\nLandau–Pekar
effective mass, as expected.\r\nFor the Fröhlich polaron describing electrons
in polar crystals where the dispersion relation is\r\nof the optical type and
the form factor is formally UV–singular due to the nature of the point\r\ncharge-dipole
interaction, we are able to give the corresponding upper bound. In contrast to\r\nthe
regular case, this requires the inclusion of the quantum fluctuations of the phonon
field,\r\nwhich makes the problem considerably more difficult.\r\nThe results
are supplemented by studies on the absolute ground-state energy at strong coupling,\r\na
proof of the divergence of the effective mass with the coupling constant for a
wide class of\r\npolaron models, as well as the discussion of the apparent UV
singularity of the Fröhlich model\r\nand the application of the techniques used
for its removal for the energy estimates.\r\n"
acknowledged_ssus:
- _id: SSU
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Krzysztof
full_name: Mysliwy, Krzysztof
id: 316457FC-F248-11E8-B48F-1D18A9856A87
last_name: Mysliwy
citation:
ama: 'Mysliwy K. Polarons in Bose gases and polar crystals: Some rigorous energy
estimates. 2022. doi:10.15479/at:ista:11473'
apa: 'Mysliwy, K. (2022). Polarons in Bose gases and polar crystals: Some rigorous
energy estimates. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:11473'
chicago: 'Mysliwy, Krzysztof. “Polarons in Bose Gases and Polar Crystals: Some Rigorous
Energy Estimates.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:11473.'
ieee: 'K. Mysliwy, “Polarons in Bose gases and polar crystals: Some rigorous energy
estimates,” Institute of Science and Technology Austria, 2022.'
ista: 'Mysliwy K. 2022. Polarons in Bose gases and polar crystals: Some rigorous
energy estimates. Institute of Science and Technology Austria.'
mla: 'Mysliwy, Krzysztof. Polarons in Bose Gases and Polar Crystals: Some Rigorous
Energy Estimates. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:11473.'
short: 'K. Mysliwy, Polarons in Bose Gases and Polar Crystals: Some Rigorous Energy
Estimates, Institute of Science and Technology Austria, 2022.'
corr_author: '1'
date_created: 2022-06-30T12:15:03Z
date_published: 2022-07-01T00:00:00Z
date_updated: 2026-04-07T14:14:52Z
day: '01'
ddc:
- '515'
- '539'
degree_awarded: PhD
department:
- _id: GradSch
- _id: RoSe
doi: 10.15479/at:ista:11473
ec_funded: 1
file:
- access_level: open_access
checksum: 7970714a20a6052f75fb27a6c3e9976e
content_type: application/pdf
creator: kmysliwy
date_created: 2022-07-05T08:12:56Z
date_updated: 2022-07-05T08:12:56Z
file_id: '11486'
file_name: thes1_no_isbn_2_1b.pdf
file_size: 1830973
relation: main_file
success: 1
- access_level: closed
checksum: 647a2011fdf56277096c9350fefe1097
content_type: application/zip
creator: kmysliwy
date_created: 2022-07-05T08:15:52Z
date_updated: 2022-07-05T08:17:12Z
file_id: '11487'
file_name: thes_source.zip
file_size: 5831060
relation: source_file
file_date_updated: 2022-07-05T08:17:12Z
fulldoi: https://doi.org/10.15479/at:ista:11473
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '138'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '10564'
relation: part_of_dissertation
status: public
- id: '8705'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
title: 'Polarons in Bose gases and polar crystals: Some rigorous energy estimates'
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2022'
...
---
_id: '11488'
abstract:
- lang: eng
text: Hydrogen Lyα haloes (LAHs) are commonly used as a tracer of the circumgalactic
medium (CGM) at high redshifts. In this work, we aim to explore the existence
of Lyα haloes around individual UV-selected galaxies, rather than around Lyα emitters
(LAEs), at high redshifts. Our sample was continuum-selected with F775W ≤ 27.5,
and spectroscopic redshifts were assigned or constrained for all the sources thanks
to the deepest (100- to 140-h) existing Very Large Telescope (VLT)/Multi-Unit
Spectroscopic Explorer (MUSE) data with adaptive optics. The final sample includes
21 galaxies that are purely F775W-magnitude selected within the redshift range
z ≈ 2.9 − 4.4 and within a UV magnitude range −20 ≤ M1500 ≤ −18, thus avoiding
any bias toward LAEs. We tested whether galaxy’s Lyα emission is significantly
more extended than the MUSE PSF-convolved continuum component. We find 17 LAHs
and four non-LAHs. We report the first individual detections of extended Lyα emission
around non-LAEs. The Lyα halo fraction is thus as high as 81.0−11.2+10.3%, which
is close to that for LAEs at z = 3 − 6 in the literature. This implies that UV-selected
galaxies generally have a large amount of hydrogen in their CGM. We derived the
mean surface brightness (SB) profile for our LAHs with cosmic dimming corrections
and find that Lyα emission extends to 5.4 arcsec (≃40 physical kpc at the midpoint
redshift z = 3.6) above the typical 1σ SB limit. The incidence rate of surrounding
gas detected in Lyα per one-dimensional line of sight per unit redshift, dn/dz,
is estimated to be 0.76−0.09+0.09 for galaxies with M1500 ≤ −18 mag at z ≃ 3.7.
Assuming that Lyα emission and absorption arise in the same gas, this suggests,
based on abundance matching, that LAHs trace the same gas as damped Lyα systems
(DLAs) and sub-DLAs.
acknowledgement: 'We thank the anonymous referee for constructive comments and suggestions.
We would like to express our gratitude to Edmund Christian Herenz, Leindert Boogard,
Miroslava Dessauges, Moupiya Maji, Valentin Mauerhofer, Charlotte Paola Simmonds
Wagemann, Masami Ouchi, Kazuhiro Shimasaku, Akio Inoue, and Rieko Momose for giving
insightful comments and suggestions. H.K. is grateful to Liam McCarney for useful
suggestions on English writing through the UniGE’s Tandems linguistiques. H.K. acknowledges
support from Swiss Government Excellence Scholarships and Japan Society for the
Promotion of Science (JSPS) Overseas Research Fellowship. H.K., F.L., and A.V. are
supported by the SNF grant PP00P2 176808. A.V. and T.G. are supported by the ERC
Starting Grant 757258“TRIPLE”. This work was supported by the Programme National
Cosmology et Galaxies (PNCG) of CNRS/INSU with INP and IN2P3, co-funded by CEA and
CNES. This work is based on observations taken by VLT, which is operated by European
Southern Observatory. This research made use of Astropy, which is a community-developed
core Python package for Astronomy (Astropy Collaboration 2013, 2018), and other
software and packages: MARZ, MPDAF (Piqueras et al. 2019), PHOTUTILS, Numpy (Harris
et al. 2020), Scipy (Virtanen et al. 2020), and matplotlib (Hunter 2007).'
article_number: A44
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Haruka
full_name: Kusakabe, Haruka
last_name: Kusakabe
- first_name: Anne
full_name: Verhamme, Anne
last_name: Verhamme
- first_name: Jérémy
full_name: Blaizot, Jérémy
last_name: Blaizot
- first_name: Thibault
full_name: Garel, Thibault
last_name: Garel
- first_name: Lutz
full_name: Wisotzki, Lutz
last_name: Wisotzki
- first_name: Floriane
full_name: Leclercq, Floriane
last_name: Leclercq
- first_name: Roland
full_name: Bacon, Roland
last_name: Bacon
- first_name: Joop
full_name: Schaye, Joop
last_name: Schaye
- first_name: Sofia G.
full_name: Gallego, Sofia G.
last_name: Gallego
- first_name: Josephine
full_name: Kerutt, Josephine
last_name: Kerutt
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Michael
full_name: Maseda, Michael
last_name: Maseda
- first_name: Themiya
full_name: Nanayakkara, Themiya
last_name: Nanayakkara
- first_name: Roser
full_name: Pelló, Roser
last_name: Pelló
- first_name: Johan
full_name: Richard, Johan
last_name: Richard
- first_name: Laurence
full_name: Tresse, Laurence
last_name: Tresse
- first_name: Tanya
full_name: Urrutia, Tanya
last_name: Urrutia
- first_name: Eloïse
full_name: Vitte, Eloïse
last_name: Vitte
citation:
ama: 'Kusakabe H, Verhamme A, Blaizot J, et al. The MUSE eXtremely Deep Field: Individual
detections of Lyα haloes around rest-frame UV-selected galaxies at z
≃ 2.9–4.4. Astronomy & Astrophysics. 2022;660. doi:10.1051/0004-6361/202142302'
apa: 'Kusakabe, H., Verhamme, A., Blaizot, J., Garel, T., Wisotzki, L., Leclercq,
F., … Vitte, E. (2022). The MUSE eXtremely Deep Field: Individual detections of
Lyα haloes around rest-frame UV-selected galaxies at z ≃ 2.9–4.4.
Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202142302'
chicago: 'Kusakabe, Haruka, Anne Verhamme, Jérémy Blaizot, Thibault Garel, Lutz
Wisotzki, Floriane Leclercq, Roland Bacon, et al. “The MUSE EXtremely Deep Field:
Individual Detections of Lyα Haloes around Rest-Frame UV-Selected Galaxies
at z ≃ 2.9–4.4.” Astronomy & Astrophysics. EDP Sciences, 2022.
https://doi.org/10.1051/0004-6361/202142302.'
ieee: 'H. Kusakabe et al., “The MUSE eXtremely Deep Field: Individual detections
of Lyα haloes around rest-frame UV-selected galaxies at z ≃ 2.9–4.4,”
Astronomy & Astrophysics, vol. 660. EDP Sciences, 2022.'
ista: 'Kusakabe H, Verhamme A, Blaizot J, Garel T, Wisotzki L, Leclercq F, Bacon
R, Schaye J, Gallego SG, Kerutt J, Matthee JJ, Maseda M, Nanayakkara T, Pelló
R, Richard J, Tresse L, Urrutia T, Vitte E. 2022. The MUSE eXtremely Deep Field:
Individual detections of Lyα haloes around rest-frame UV-selected galaxies
at z ≃ 2.9–4.4. Astronomy & Astrophysics. 660, A44.'
mla: 'Kusakabe, Haruka, et al. “The MUSE EXtremely Deep Field: Individual Detections
of Lyα Haloes around Rest-Frame UV-Selected Galaxies at z ≃ 2.9–4.4.”
Astronomy & Astrophysics, vol. 660, A44, EDP Sciences, 2022, doi:10.1051/0004-6361/202142302.'
short: H. Kusakabe, A. Verhamme, J. Blaizot, T. Garel, L. Wisotzki, F. Leclercq,
R. Bacon, J. Schaye, S.G. Gallego, J. Kerutt, J.J. Matthee, M. Maseda, T. Nanayakkara,
R. Pelló, J. Richard, L. Tresse, T. Urrutia, E. Vitte, Astronomy & Astrophysics
660 (2022).
date_created: 2022-07-05T14:27:26Z
date_published: 2022-04-07T00:00:00Z
date_updated: 2022-07-19T09:33:24Z
day: '07'
doi: 10.1051/0004-6361/202142302
extern: '1'
external_id:
arxiv:
- '2201.07257'
fulldoi: https://doi.org/10.1051/0004-6361/202142302
intvolume: ' 660'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: high-redshift / galaxies: formation / galaxies: evolution / cosmology:
observations'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2201.07257
month: '04'
oa: 1
oa_version: Published Version
publication: Astronomy & Astrophysics
publication_identifier:
eissn:
- 1432-0746
issn:
- 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The MUSE eXtremely Deep Field: Individual detections of Lyα haloes
around rest-frame UV-selected galaxies at z ≃ 2.9–4.4'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 660
year: '2022'
...
---
_id: '11489'
abstract:
- lang: eng
text: Much of plant development depends on cell-to-cell redistribution of the plant
hormone auxin, which is facilitated by the plasma membrane (PM) localized PIN
FORMED (PIN) proteins. Auxin export activity, developmental roles, subcellular
trafficking, and polarity of PINs have been well studied, but their structure
remains elusive besides a rough outline that they contain two groups of 5 alpha-helices
connected by a large hydrophilic loop (HL). Here, we focus on the PIN1 HL as we
could produce it in sufficient quantities for biochemical investigations to provide
insights into its secondary structure. Circular dichroism (CD) studies revealed
its nature as an intrinsically disordered protein (IDP), manifested by the increase
of structure content upon thermal melting. Consistent with IDPs serving as interaction
platforms, PIN1 loops homodimerize. PIN1 HL cytoplasmic overexpression in Arabidopsis
disrupts early endocytic trafficking of PIN1 and PIN2 and causes defects in the
cotyledon vasculature formation. In summary, we demonstrate that PIN1 HL has an
intrinsically disordered nature, which must be considered to gain further structural
insights. Some secondary structures may form transiently during pairing with known
and yet-to-be-discovered interactors.
acknowledgement: 'We thank Charo del Genio from Coventry University and Richard Napier
from the University of Warwick for helpful discussion concerning protein modeling
and inspiration concerning CD spectroscopy, respectively. We thank Jan Hejatko for
sharing the published AHP2 construct. We also thank Josef Houser from the core facility
BIC CEITEC for valuable assistance, discussions, and ideas relating to CD. We acknowledge
the: Core Facility CELLIM of CEITEC supported by the Czech-BioImaging large RI project
(LM2018129 funded by MEYS CR), part of the Euro-BioImaging (www.eurobioimaging.eu
accessed on 1 January 2016) ALM and medical imaging Node (Brno, CZ), CF Biomolecular
Interactions and Crystallization of CIISB, Instruct-CZ Centre, supported by MEYS
CR (LM2018127) and European Regional Development Fund-Project “UP CIISB“ (No. CZ.02.1.01/0.0/0.0/18_046/0015974)
for their support with obtaining scientific data presented in this paper; Plant
Sciences Core Facility of CEITEC Masaryk University for technical support. Open
Access Funding by the Austrian Science Fund (FWF).'
article_processing_charge: Yes
article_type: original
author:
- first_name: V
full_name: Bilanovičová, V
last_name: Bilanovičová
- first_name: N
full_name: Rýdza, N
last_name: Rýdza
- first_name: L
full_name: Koczka, L
last_name: Koczka
- first_name: M
full_name: Hess, M
last_name: Hess
- first_name: E
full_name: Feraru, E
last_name: Feraru
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: T
full_name: Nodzyński, T
last_name: Nodzyński
citation:
ama: Bilanovičová V, Rýdza N, Koczka L, et al. The hydrophilic loop of Arabidopsis
PIN1 auxin efflux carrier harbors hallmarks of an intrinsically disordered protein.
International Journal of Molecular Sciences. 2022;23(11):6352. doi:10.3390/ijms23116352
apa: Bilanovičová, V., Rýdza, N., Koczka, L., Hess, M., Feraru, E., Friml, J., &
Nodzyński, T. (2022). The hydrophilic loop of Arabidopsis PIN1 auxin efflux carrier
harbors hallmarks of an intrinsically disordered protein. International Journal
of Molecular Sciences. MDPI. https://doi.org/10.3390/ijms23116352
chicago: Bilanovičová, V, N Rýdza, L Koczka, M Hess, E Feraru, Jiří Friml, and T
Nodzyński. “The Hydrophilic Loop of Arabidopsis PIN1 Auxin Efflux Carrier Harbors
Hallmarks of an Intrinsically Disordered Protein.” International Journal of
Molecular Sciences. MDPI, 2022. https://doi.org/10.3390/ijms23116352.
ieee: V. Bilanovičová et al., “The hydrophilic loop of Arabidopsis PIN1 auxin
efflux carrier harbors hallmarks of an intrinsically disordered protein,” International
Journal of Molecular Sciences, vol. 23, no. 11. MDPI, p. 6352, 2022.
ista: Bilanovičová V, Rýdza N, Koczka L, Hess M, Feraru E, Friml J, Nodzyński T.
2022. The hydrophilic loop of Arabidopsis PIN1 auxin efflux carrier harbors hallmarks
of an intrinsically disordered protein. International Journal of Molecular Sciences.
23(11), 6352.
mla: Bilanovičová, V., et al. “The Hydrophilic Loop of Arabidopsis PIN1 Auxin Efflux
Carrier Harbors Hallmarks of an Intrinsically Disordered Protein.” International
Journal of Molecular Sciences, vol. 23, no. 11, MDPI, 2022, p. 6352, doi:10.3390/ijms23116352.
short: V. Bilanovičová, N. Rýdza, L. Koczka, M. Hess, E. Feraru, J. Friml, T. Nodzyński,
International Journal of Molecular Sciences 23 (2022) 6352.
corr_author: '1'
date_created: 2022-07-05T15:14:34Z
date_published: 2022-06-06T00:00:00Z
date_updated: 2025-04-15T08:12:07Z
day: '06'
ddc:
- '570'
department:
- _id: JiFr
doi: 10.3390/ijms23116352
external_id:
isi:
- '000808733300001'
pmid:
- '35683031'
file:
- access_level: open_access
checksum: e997a57a928ec9d51fad8ce824a05935
content_type: application/pdf
creator: cchlebak
date_created: 2022-07-06T07:36:59Z
date_updated: 2022-07-06T07:36:59Z
file_id: '11492'
file_name: 2022_IntJMolSci_Bilanovicova.pdf
file_size: 2324542
relation: main_file
success: 1
file_date_updated: 2022-07-06T07:36:59Z
fulldoi: https://doi.org/10.3390/ijms23116352
has_accepted_license: '1'
intvolume: ' 23'
isi: 1
issue: '11'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: '6352'
pmid: 1
project:
- _id: 262EF96E-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P29988
name: RNA-directed DNA methylation in plant development
publication: International Journal of Molecular Sciences
publication_identifier:
issn:
- 1422-0067
publication_status: published
publisher: MDPI
quality_controlled: '1'
scopus_import: '1'
status: public
title: The hydrophilic loop of Arabidopsis PIN1 auxin efflux carrier harbors hallmarks
of an intrinsically disordered protein
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2022'
...
---
_id: '11490'
abstract:
- lang: eng
text: Directly characterising the first generations of stars in distant galaxies
is a key quest of observational cosmology. We present a case study of ID53 at
z = 4.77, the UV-brightest (but L⋆) star-forming galaxy at z > 3 in the MUSE eXtremely
Deep Field with a mass of ≈109 M⊙. In addition to very strong Lyman-α (Lyα) emission,
we clearly detect the (stellar) continuum and an N V P Cygni feature, interstellar
absorption, fine-structure emission and nebular C IV emission lines in the 140
h spectrum. Continuum emission from two spatially resolved components in Hubble
Space Telescope data are blended in the MUSE data, but we show that the nebular
C IV emission originates from a subcomponent of the galaxy. The UV spectrum can
be fit with recent BPASS stellar population models combined with single-burst
or continuous star formation histories (SFHs), a standard initial mass function,
and an attenuation law. Models with a young age and low metallicity (log10(age/yr)
= 6.5–7.6 and [Z/H] = −2.15 to −1.15) are preferred, but the details depend on
the assumed SFH. The intrinsic Hα luminosity of the best-fit models is an order
of magnitude higher than the Hα luminosity inferred from Spitzer/IRAC data, which
either suggests a high escape fraction of ionising photons, a high relative attenuation
of nebular to stellar dust, or a complex SFH. The metallicity appears lower than
the metallicity in more massive galaxies at z = 3 − 5, consistent with the scenario
according to which younger galaxies have lower metallicities. This chemical immaturity
likely facilitates Lyα escape, explaining why the Lyα equivalent width is anti-correlated
with stellar metallicity. Finally, we stress that uncertainties in SFHs impose
a challenge for future inferences of the stellar metallicity of young galaxies.
This highlights the need for joint (spatially resolved) analyses of stellar spectra
and photo-ionisation models.
acknowledgement: We thank the referee for thoughtful and constructive comments that
have improved the quality of this manuscript. Based on observations collected at
the European Southern Observatory under ESO programme 1101.A-0127. This work made
use of v2.2.1 of the Binary Population and Spectral Synthesis (BPASS) models as
described in Eldridge et al. (2017) and Stanway & Eldridge (2018). A.F. acknowledges
the support from grant PRIN MIUR2017-20173ML3WW_001. T.N. acknowledges support from
Australian Research Council Laureate Fellowship FL180100060.
article_number: A10
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Anna
full_name: Feltre, Anna
last_name: Feltre
- first_name: Michael
full_name: Maseda, Michael
last_name: Maseda
- first_name: Themiya
full_name: Nanayakkara, Themiya
last_name: Nanayakkara
- first_name: Leindert
full_name: Boogaard, Leindert
last_name: Boogaard
- first_name: Roland
full_name: Bacon, Roland
last_name: Bacon
- first_name: Anne
full_name: Verhamme, Anne
last_name: Verhamme
- first_name: Floriane
full_name: Leclercq, Floriane
last_name: Leclercq
- first_name: Haruka
full_name: Kusakabe, Haruka
last_name: Kusakabe
- first_name: Tanya
full_name: Urrutia, Tanya
last_name: Urrutia
- first_name: Lutz
full_name: Wisotzki, Lutz
last_name: Wisotzki
citation:
ama: 'Matthee JJ, Feltre A, Maseda M, et al. Deciphering stellar metallicities in
the early universe: Case study of a young galaxy at z = 4.77 in the MUSE eXtremely
Deep Field. Astronomy & Astrophysics. 2022;660. doi:10.1051/0004-6361/202142187'
apa: 'Matthee, J. J., Feltre, A., Maseda, M., Nanayakkara, T., Boogaard, L., Bacon,
R., … Wisotzki, L. (2022). Deciphering stellar metallicities in the early universe:
Case study of a young galaxy at z = 4.77 in the MUSE eXtremely Deep Field. Astronomy
& Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202142187'
chicago: 'Matthee, Jorryt J, Anna Feltre, Michael Maseda, Themiya Nanayakkara, Leindert
Boogaard, Roland Bacon, Anne Verhamme, et al. “Deciphering Stellar Metallicities
in the Early Universe: Case Study of a Young Galaxy at z = 4.77 in the MUSE EXtremely
Deep Field.” Astronomy & Astrophysics. EDP Sciences, 2022. https://doi.org/10.1051/0004-6361/202142187.'
ieee: 'J. J. Matthee et al., “Deciphering stellar metallicities in the early
universe: Case study of a young galaxy at z = 4.77 in the MUSE eXtremely Deep
Field,” Astronomy & Astrophysics, vol. 660. EDP Sciences, 2022.'
ista: 'Matthee JJ, Feltre A, Maseda M, Nanayakkara T, Boogaard L, Bacon R, Verhamme
A, Leclercq F, Kusakabe H, Urrutia T, Wisotzki L. 2022. Deciphering stellar metallicities
in the early universe: Case study of a young galaxy at z = 4.77 in the MUSE eXtremely
Deep Field. Astronomy & Astrophysics. 660, A10.'
mla: 'Matthee, Jorryt J., et al. “Deciphering Stellar Metallicities in the Early
Universe: Case Study of a Young Galaxy at z = 4.77 in the MUSE EXtremely Deep
Field.” Astronomy & Astrophysics, vol. 660, A10, EDP Sciences, 2022,
doi:10.1051/0004-6361/202142187.'
short: J.J. Matthee, A. Feltre, M. Maseda, T. Nanayakkara, L. Boogaard, R. Bacon,
A. Verhamme, F. Leclercq, H. Kusakabe, T. Urrutia, L. Wisotzki, Astronomy &
Astrophysics 660 (2022).
date_created: 2022-07-05T15:25:35Z
date_published: 2022-03-30T00:00:00Z
date_updated: 2024-10-14T11:31:22Z
day: '30'
doi: 10.1051/0004-6361/202142187
extern: '1'
external_id:
arxiv:
- '2111.14855'
fulldoi: https://doi.org/10.1051/0004-6361/202142187
intvolume: ' 660'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: high-redshift / techniques: spectroscopic / galaxies: stellar content
/ galaxies: formation'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2111.14855
month: '03'
oa: 1
oa_version: Published Version
publication: Astronomy & Astrophysics
publication_identifier:
eissn:
- 1432-0746
issn:
- 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Deciphering stellar metallicities in the early universe: Case study of a young
galaxy at z = 4.77 in the MUSE eXtremely Deep Field'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 660
year: '2022'
...
---
_id: '11497'
abstract:
- lang: eng
text: "Context. The hydrogen Lyman α line is often the only measurable feature in
optical spectra of high-redshift galaxies. Its shape and strength are influenced
by radiative transfer processes and the properties of the underlying stellar population.
High equivalent widths of several hundred Å are especially hard to explain by
models and could point towards unusual stellar populations, for example with low
metallicities, young stellar ages, and a top-heavy initial mass function. Other
aspects influencing equivalent widths are the morphology of the galaxy and its
gas properties.\r\nAims. The aim of this study is to better understand the connection
between the Lyman α rest-frame equivalent width (EW0) and spectral properties
as well as ultraviolet (UV) continuum morphology by obtaining reliable EW0 histograms
for a statistical sample of galaxies and by assessing the fraction of objects
with large equivalent widths.\r\nMethods. We used integral field spectroscopy
from the Multi Unit Spectroscopic Explorer (MUSE) combined with broad-band data
from the Hubble Space Telescope (HST) to measure EW0. We analysed the emission
lines of 1920 Lyman α emitters (LAEs) detected in the full MUSE-Wide (one hour
exposure time) and MUSE-Deep (ten hour exposure time) surveys and found UV continuum
counterparts in archival HST data. We fitted the UV continuum photometric images
using the Galfit software to gain morphological information on the rest-UV emission
and fitted the spectra obtained from MUSE to determine the double peak fraction,
asymmetry, full-width at half maximum, and flux of the Lyman α line.\r\nResults.
The two surveys show different histograms of Lyman α EW0. In MUSE-Wide, 20% of
objects have EW0 > 240 Å, while this fraction is only 11% in MUSE-Deep and ≈16%
for the full sample. This includes objects without HST continuum counterparts
(one-third of our sample), for which we give lower limits for EW0. The object
with the highest securely measured EW0 has EW0 = 589 ± 193 Å (the highest lower
limit being EW0 = 4464 Å). We investigate the connection between EW0 and Lyman
α spectral or UV continuum morphological properties.\r\nConclusions. The survey
depth has to be taken into account when studying EW0 distributions. We find that
in general, high EW0 objects can have a wide range of spectral and UV morphological
properties, which might reflect that the underlying causes for high EW0 values
are equally varied."
acknowledgement: We thank the referee for thoughtful and constructive comments that
have improved the quality of this manuscript. Based on observations collected at
the European Southern Observatory under ESO programme 1101.A-0127. This work made
use of v2.2.1 of the Binary Population and Spectral Synthesis (BPASS) models as
described in Eldridge et al. (2017) and Stanway & Eldridge (2018). A.F. acknowledges
the support from grant PRIN MIUR2017-20173ML3WW_001. T.N. acknowledges support from
Australian Research Council Laureate Fellowship FL180100060.
article_number: '183'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: J.
full_name: Kerutt, J.
last_name: Kerutt
- first_name: L.
full_name: Wisotzki, L.
last_name: Wisotzki
- first_name: A.
full_name: Verhamme, A.
last_name: Verhamme
- first_name: K. B.
full_name: Schmidt, K. B.
last_name: Schmidt
- first_name: F.
full_name: Leclercq, F.
last_name: Leclercq
- first_name: E. C.
full_name: Herenz, E. C.
last_name: Herenz
- first_name: T.
full_name: Urrutia, T.
last_name: Urrutia
- first_name: T.
full_name: Garel, T.
last_name: Garel
- first_name: T.
full_name: Hashimoto, T.
last_name: Hashimoto
- first_name: M.
full_name: Maseda, M.
last_name: Maseda
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: H.
full_name: Kusakabe, H.
last_name: Kusakabe
- first_name: J.
full_name: Schaye, J.
last_name: Schaye
- first_name: J.
full_name: Richard, J.
last_name: Richard
- first_name: B.
full_name: Guiderdoni, B.
last_name: Guiderdoni
- first_name: V.
full_name: Mauerhofer, V.
last_name: Mauerhofer
- first_name: T.
full_name: Nanayakkara, T.
last_name: Nanayakkara
- first_name: E.
full_name: Vitte, E.
last_name: Vitte
citation:
ama: Kerutt J, Wisotzki L, Verhamme A, et al. Equivalent widths of Lyman α emitters
in MUSE-Wide and MUSE-Deep. Astronomy & Astrophysics. 2022;659. doi:10.1051/0004-6361/202141900
apa: Kerutt, J., Wisotzki, L., Verhamme, A., Schmidt, K. B., Leclercq, F., Herenz,
E. C., … Vitte, E. (2022). Equivalent widths of Lyman α emitters in MUSE-Wide
and MUSE-Deep. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202141900
chicago: Kerutt, J., L. Wisotzki, A. Verhamme, K. B. Schmidt, F. Leclercq, E. C.
Herenz, T. Urrutia, et al. “Equivalent Widths of Lyman α Emitters in MUSE-Wide
and MUSE-Deep.” Astronomy & Astrophysics. EDP Sciences, 2022. https://doi.org/10.1051/0004-6361/202141900.
ieee: J. Kerutt et al., “Equivalent widths of Lyman α emitters in MUSE-Wide
and MUSE-Deep,” Astronomy & Astrophysics, vol. 659. EDP Sciences, 2022.
ista: Kerutt J, Wisotzki L, Verhamme A, Schmidt KB, Leclercq F, Herenz EC, Urrutia
T, Garel T, Hashimoto T, Maseda M, Matthee JJ, Kusakabe H, Schaye J, Richard J,
Guiderdoni B, Mauerhofer V, Nanayakkara T, Vitte E. 2022. Equivalent widths of
Lyman α emitters in MUSE-Wide and MUSE-Deep. Astronomy & Astrophysics. 659,
183.
mla: Kerutt, J., et al. “Equivalent Widths of Lyman α Emitters in MUSE-Wide and
MUSE-Deep.” Astronomy & Astrophysics, vol. 659, 183, EDP Sciences,
2022, doi:10.1051/0004-6361/202141900.
short: J. Kerutt, L. Wisotzki, A. Verhamme, K.B. Schmidt, F. Leclercq, E.C. Herenz,
T. Urrutia, T. Garel, T. Hashimoto, M. Maseda, J.J. Matthee, H. Kusakabe, J. Schaye,
J. Richard, B. Guiderdoni, V. Mauerhofer, T. Nanayakkara, E. Vitte, Astronomy
& Astrophysics 659 (2022).
date_created: 2022-07-06T08:17:27Z
date_published: 2022-03-25T00:00:00Z
date_updated: 2022-07-19T09:47:16Z
day: '25'
doi: 10.1051/0004-6361/202141900
extern: '1'
external_id:
arxiv:
- '2202.06642'
fulldoi: https://doi.org/10.1051/0004-6361/202141900
intvolume: ' 659'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: high-redshift / galaxies: formation / galaxies: evolution / cosmology:
observations'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2202.06642
month: '03'
oa: 1
oa_version: Published Version
publication: Astronomy & Astrophysics
publication_identifier:
eissn:
- 1432-0746
issn:
- 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Equivalent widths of Lyman α emitters in MUSE-Wide and MUSE-Deep
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 659
year: '2022'
...
---
_id: '11509'
abstract:
- lang: eng
text: We present Keck/LRIS follow-up spectroscopy for 13 photometric candidates
of extremely metal-poor galaxies (EMPGs) selected by a machine-learning technique
applied to the deep (∼26 AB mag) optical and wide-area (∼500 deg2) Subaru imaging
data in the EMPRESS survey. Nine out of the 13 candidates are EMPGs with an oxygen
abundance (O/H) less than ∼10% solar value (O/H)⊙, and four sources are contaminants
of moderately metal-rich galaxies or no emission-line objects. Notably, two out
of the nine EMPGs have extremely low stellar masses and oxygen abundances of 5
× 10⁴x–7 × -10⁵ M⊙ and 2%–3% (O/H)⊙, respectively. With a sample of five EMPGs
with (Fe/O) measurements, two (three) of which are taken from this study (the
literature), we confirm that two EMPGs with the lowest (O/H) ratios of ∼2% (O/H)⊙
show high (Fe/O) ratios of ∼0.1, close to the solar abundance ratio. Comparing
galaxy chemical enrichment models, we find that the two EMPGs cannot be explained
by a scenario of metal-poor gas accretion/episodic star formation history due
to their low (N/O) ratios. We conclude that the two EMPGs can be reproduced by
the inclusion of bright hypernovae and/or hypothetical pair-instability supernovae
(SNe) preferentially produced in a metal-poor environment. This conclusion implies
that primordial galaxies at z ∼ 10 could have a high abundance of Fe that did
not originate from Type Ia SNe with delays and that Fe may not serve as a cosmic
clock for primordial galaxies.
acknowledgement: We thank the referee for the valuable comments. We are also grateful
to Koh Takahashi, Nozomu Tominaga, Chiaki Kobayashi, Yutaka Hirai, and Daichi Kashino
for having useful discussions. This paper includes data gathered with the 10 m Keck
Telescope located at W. M. Keck Observatory, Hawaii. We thank the staff of Keck
Observatory for their help with the observations. The Hyper Suprime-Cam (HSC) collaboration
includes the astronomical communities of Japan and Taiwan, and Princeton University.
The HSC instrumentation and software were developed by the National Astronomical
Observatory of Japan (NAOJ), the Kavli Institute for the Physics and Mathematics
of the Universe (Kavli IPMU), the University of Tokyo, the High Energy Accelerator
Research Organization (KEK), the Academia Sinica Institute for Astronomy and Astrophysics
in Taiwan (ASIAA), and Princeton University. Based on data collected at the Subaru
Telescope and retrieved from the HSC data archive system, which is operated by the
Subaru Telescope and Astronomy Data Center at NAOJ. This work was supported by the
joint research program of the Institute for Cosmic Ray Research (ICRR), University
of Tokyo. The Cosmic Dawn Center is funded by the Danish National Research Foundation
under grant No. 140. S.F. acknowledges support from the European Research Council
(ERC) Consolidator Grant funding scheme (project ConTExt, grant No. 648179). This
project has received funding from the European Union’s Horizon 2020 research and
innovation program under the Marie Sklodowska-Curie grant agreement No. 847523 “INTERACTIONS.”
This work is supported by World Premier International Research Center Initiative
(WPI Initiative), MEXT, Japan, as well as the KAKENHI Grant-in-Aid for Scientific
Research (A; 15H02064, 17H01110, 17H01114, 20H00180, and 21H04467) through the Japan
Society for the Promotion of Science (JSPS). This work has been supported in part
by JSPS KAKENHI grant Nos. JP17K05382, JP20K04024, and JP21H04499 (K.N.). Yuki Isobe,
Kimihiko Nakajima, Yuichi Harikane, Takashi Kojima, and Masato Onodera are supported
by JSPS KAKENHI grant Nos. 21J20785, 20K22373,19J01222, 18J12840, and 17K14257,
respectively.
article_number: '111'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Yuki
full_name: Isobe, Yuki
last_name: Isobe
- first_name: Masami
full_name: Ouchi, Masami
last_name: Ouchi
- first_name: Akihiro
full_name: Suzuki, Akihiro
last_name: Suzuki
- first_name: Takashi J.
full_name: Moriya, Takashi J.
last_name: Moriya
- first_name: Kimihiko
full_name: Nakajima, Kimihiko
last_name: Nakajima
- first_name: Ken’ichi
full_name: Nomoto, Ken’ichi
last_name: Nomoto
- first_name: Michael
full_name: Rauch, Michael
last_name: Rauch
- first_name: Yuichi
full_name: Harikane, Yuichi
last_name: Harikane
- first_name: Takashi
full_name: Kojima, Takashi
last_name: Kojima
- first_name: Yoshiaki
full_name: Ono, Yoshiaki
last_name: Ono
- first_name: Seiji
full_name: Fujimoto, Seiji
last_name: Fujimoto
- first_name: Akio K.
full_name: Inoue, Akio K.
last_name: Inoue
- first_name: Ji Hoon
full_name: Kim, Ji Hoon
last_name: Kim
- first_name: Yutaka
full_name: Komiyama, Yutaka
last_name: Komiyama
- first_name: Haruka
full_name: Kusakabe, Haruka
last_name: Kusakabe
- first_name: Chien-Hsiu
full_name: Lee, Chien-Hsiu
last_name: Lee
- first_name: Michael
full_name: Maseda, Michael
last_name: Maseda
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Leo
full_name: Michel-Dansac, Leo
last_name: Michel-Dansac
- first_name: Tohru
full_name: Nagao, Tohru
last_name: Nagao
- first_name: Themiya
full_name: Nanayakkara, Themiya
last_name: Nanayakkara
- first_name: Moka
full_name: Nishigaki, Moka
last_name: Nishigaki
- first_name: Masato
full_name: Onodera, Masato
last_name: Onodera
- first_name: Yuma
full_name: Sugahara, Yuma
last_name: Sugahara
- first_name: Yi
full_name: Xu, Yi
last_name: Xu
citation:
ama: 'Isobe Y, Ouchi M, Suzuki A, et al. EMPRESS. IV. Extremely metal-poor galaxies
including very low-mass primordial systems with M∗= 104-105⊙
and 2%–3% (O/H): High (Fe/O) suggestive of metal enrichment by hypernovae/pair-instability
supernovae. The Astrophysical Journal. 2022;925(2). doi:10.3847/1538-4357/ac3509'
apa: 'Isobe, Y., Ouchi, M., Suzuki, A., Moriya, T. J., Nakajima, K., Nomoto, K.,
… Xu, Y. (2022). EMPRESS. IV. Extremely metal-poor galaxies including very low-mass
primordial systems with M∗= 104-105⊙ and 2%–3% (O/H): High
(Fe/O) suggestive of metal enrichment by hypernovae/pair-instability supernovae.
The Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ac3509'
chicago: 'Isobe, Yuki, Masami Ouchi, Akihiro Suzuki, Takashi J. Moriya, Kimihiko
Nakajima, Ken’ichi Nomoto, Michael Rauch, et al. “EMPRESS. IV. Extremely Metal-Poor
Galaxies Including Very Low-Mass Primordial Systems with M∗= 104-105⊙
and 2%–3% (O/H): High (Fe/O) Suggestive of Metal Enrichment by Hypernovae/Pair-Instability
Supernovae.” The Astrophysical Journal. IOP Publishing, 2022. https://doi.org/10.3847/1538-4357/ac3509.'
ieee: 'Y. Isobe et al., “EMPRESS. IV. Extremely metal-poor galaxies including
very low-mass primordial systems with M∗= 104-105⊙ and 2%–3%
(O/H): High (Fe/O) suggestive of metal enrichment by hypernovae/pair-instability
supernovae,” The Astrophysical Journal, vol. 925, no. 2. IOP Publishing,
2022.'
ista: 'Isobe Y, Ouchi M, Suzuki A, Moriya TJ, Nakajima K, Nomoto K, Rauch M, Harikane
Y, Kojima T, Ono Y, Fujimoto S, Inoue AK, Kim JH, Komiyama Y, Kusakabe H, Lee
C-H, Maseda M, Matthee JJ, Michel-Dansac L, Nagao T, Nanayakkara T, Nishigaki
M, Onodera M, Sugahara Y, Xu Y. 2022. EMPRESS. IV. Extremely metal-poor galaxies
including very low-mass primordial systems with M∗= 104-105⊙
and 2%–3% (O/H): High (Fe/O) suggestive of metal enrichment by hypernovae/pair-instability
supernovae. The Astrophysical Journal. 925(2), 111.'
mla: 'Isobe, Yuki, et al. “EMPRESS. IV. Extremely Metal-Poor Galaxies Including
Very Low-Mass Primordial Systems with M∗= 104-105⊙ and 2%–3%
(O/H): High (Fe/O) Suggestive of Metal Enrichment by Hypernovae/Pair-Instability
Supernovae.” The Astrophysical Journal, vol. 925, no. 2, 111, IOP Publishing,
2022, doi:10.3847/1538-4357/ac3509.'
short: Y. Isobe, M. Ouchi, A. Suzuki, T.J. Moriya, K. Nakajima, K. Nomoto, M. Rauch,
Y. Harikane, T. Kojima, Y. Ono, S. Fujimoto, A.K. Inoue, J.H. Kim, Y. Komiyama,
H. Kusakabe, C.-H. Lee, M. Maseda, J.J. Matthee, L. Michel-Dansac, T. Nagao, T.
Nanayakkara, M. Nishigaki, M. Onodera, Y. Sugahara, Y. Xu, The Astrophysical Journal
925 (2022).
date_created: 2022-07-06T12:01:48Z
date_published: 2022-01-31T00:00:00Z
date_updated: 2022-07-21T05:51:25Z
day: '31'
doi: 10.3847/1538-4357/ac3509
extern: '1'
external_id:
arxiv:
- '2108.03850'
fulldoi: https://doi.org/10.3847/1538-4357/ac3509
intvolume: ' 925'
issue: '2'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2108.03850
month: '01'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'EMPRESS. IV. Extremely metal-poor galaxies including very low-mass primordial
systems with M∗= 10⁴-10⁵⊙ and 2%–3% (O/H): High (Fe/O) suggestive of metal enrichment
by hypernovae/pair-instability supernovae'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 925
year: '2022'
...
---
_id: '11510'
abstract:
- lang: eng
text: Galaxy evolution is driven by a variety of physical processes that are predicted
to proceed at different rates for different dark matter haloes and environments
across cosmic times. A record of this evolution is preserved in galaxy stellar
populations, which we can access using absorption-line spectroscopy. Here we explore
the large LEGA-C survey (DR3) to investigate the role of the environment and stellar
mass on stellar populations at z ∼ 0.6–1 in the COSMOS field. Leveraging the statistical
power and depth of LEGA-C, we reveal significant gradients in Dn4000 and Hδ equivalent
widths (EWs) distributions over the stellar mass versus environment 2D spaces
for the massive galaxy population (M > 1010 M⊙) at z ∼ 0.6–1.0. Dn4000 and Hδ
EWs primarily depend on stellar mass, but they also depend on environment at fixed
stellar mass. By splitting the sample into centrals and satellites, and in terms
of star-forming galaxies and quiescent galaxies, we reveal that the significant
environmental trends of Dn4000 and Hδ EW, when controlling for stellar mass, are
driven by quiescent galaxies. Regardless of being centrals or satellites, star-forming
galaxies reveal Dn4000 and Hδ EWs, which depend strongly on their stellar mass
and are completely independent of the environment at 0.6 < z < 1.0. The environmental
trends seen for satellite galaxies are fully driven by the trends that hold only
for quiescent galaxies, combined with the strong environmental dependency of the
quiescent fraction at fixed stellar mass. Our results are consistent with recent
predictions from simulations that point toward massive galaxies forming first
in overdensities or the most compact dark matter haloes.
acknowledgement: We thank the reviewer for several valuable comments that improved
the clarity of the manuscript. P.F.W. acknowledges the support of the fellowship
by the East Asian Core Observatories Association. This work is based on observations
made with ESO VLT Telescopes at the La Silla Paranal Observatory under programmes
ID 194-A.2005 and 1100.A-0949 (The LEGA-C Public Spectroscopy Survey). This project
has received funding from the European Research Council (ERC) under the European
Union—Horizon 2020 research and innovation program (grant agreement No. 683184).
article_number: '117'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: David
full_name: Sobral, David
last_name: Sobral
- first_name: Arjen
full_name: van der Wel, Arjen
last_name: van der Wel
- first_name: Rachel
full_name: Bezanson, Rachel
last_name: Bezanson
- first_name: Eric
full_name: Bell, Eric
last_name: Bell
- first_name: Adam
full_name: Muzzin, Adam
last_name: Muzzin
- first_name: Francesco
full_name: D’Eugenio, Francesco
last_name: D’Eugenio
- first_name: Behnam
full_name: Darvish, Behnam
last_name: Darvish
- first_name: Anna
full_name: Gallazzi, Anna
last_name: Gallazzi
- first_name: Po-Feng
full_name: Wu, Po-Feng
last_name: Wu
- first_name: Michael
full_name: Maseda, Michael
last_name: Maseda
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Ana
full_name: Paulino-Afonso, Ana
last_name: Paulino-Afonso
- first_name: Caroline
full_name: Straatman, Caroline
last_name: Straatman
- first_name: Pieter G.
full_name: van Dokkum, Pieter G.
last_name: van Dokkum
citation:
ama: 'Sobral D, van der Wel A, Bezanson R, et al. The LEGA-C of nature and nurture
in stellar populations at z ∼ 0.6–1.0: Dn4000 and Hδ reveal different assembly
histories for quiescent galaxies in different environments. The Astrophysical
Journal. 2022;926(2). doi:10.3847/1538-4357/ac4419'
apa: 'Sobral, D., van der Wel, A., Bezanson, R., Bell, E., Muzzin, A., D’Eugenio,
F., … van Dokkum, P. G. (2022). The LEGA-C of nature and nurture in stellar populations
at z ∼ 0.6–1.0: Dn4000 and Hδ reveal different assembly histories for quiescent
galaxies in different environments. The Astrophysical Journal. IOP Publishing.
https://doi.org/10.3847/1538-4357/ac4419'
chicago: 'Sobral, David, Arjen van der Wel, Rachel Bezanson, Eric Bell, Adam Muzzin,
Francesco D’Eugenio, Behnam Darvish, et al. “The LEGA-C of Nature and Nurture
in Stellar Populations at z ∼ 0.6–1.0: Dn4000 and Hδ Reveal Different Assembly
Histories for Quiescent Galaxies in Different Environments.” The Astrophysical
Journal. IOP Publishing, 2022. https://doi.org/10.3847/1538-4357/ac4419.'
ieee: 'D. Sobral et al., “The LEGA-C of nature and nurture in stellar populations
at z ∼ 0.6–1.0: Dn4000 and Hδ reveal different assembly histories for quiescent
galaxies in different environments,” The Astrophysical Journal, vol. 926,
no. 2. IOP Publishing, 2022.'
ista: 'Sobral D, van der Wel A, Bezanson R, Bell E, Muzzin A, D’Eugenio F, Darvish
B, Gallazzi A, Wu P-F, Maseda M, Matthee JJ, Paulino-Afonso A, Straatman C, van
Dokkum PG. 2022. The LEGA-C of nature and nurture in stellar populations at z
∼ 0.6–1.0: Dn4000 and Hδ reveal different assembly histories for quiescent galaxies
in different environments. The Astrophysical Journal. 926(2), 117.'
mla: 'Sobral, David, et al. “The LEGA-C of Nature and Nurture in Stellar Populations
at z ∼ 0.6–1.0: Dn4000 and Hδ Reveal Different Assembly Histories for Quiescent
Galaxies in Different Environments.” The Astrophysical Journal, vol. 926,
no. 2, 117, IOP Publishing, 2022, doi:10.3847/1538-4357/ac4419.'
short: D. Sobral, A. van der Wel, R. Bezanson, E. Bell, A. Muzzin, F. D’Eugenio,
B. Darvish, A. Gallazzi, P.-F. Wu, M. Maseda, J.J. Matthee, A. Paulino-Afonso,
C. Straatman, P.G. van Dokkum, The Astrophysical Journal 926 (2022).
date_created: 2022-07-06T12:38:42Z
date_published: 2022-02-17T00:00:00Z
date_updated: 2022-07-19T09:37:42Z
day: '17'
doi: 10.3847/1538-4357/ac4419
extern: '1'
external_id:
arxiv:
- '2112.08372'
fulldoi: https://doi.org/10.3847/1538-4357/ac4419
intvolume: ' 926'
issue: '2'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2112.08372
month: '02'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The LEGA-C of nature and nurture in stellar populations at z ∼ 0.6–1.0: Dn4000
and Hδ reveal different assembly histories for quiescent galaxies in different environments'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 926
year: '2022'
...
---
_id: '11511'
abstract:
- lang: eng
text: The ratio of α-elements to iron in galaxies holds valuable information about
the star formation history (SFH) since their enrichment occurs on different timescales.
The fossil record of stars in galaxies has mostly been excavated for passive galaxies,
since the light of star-forming galaxies is dominated by young stars, which have
much weaker atmospheric absorption features. Here we use the largest reference
cosmological simulation of the EAGLE project to investigate the origin of variations
in stellar α-enhancement among star-forming galaxies at z = 0, and their impact
on integrated spectra. The definition of α-enhancement in a composite stellar
population is ambiguous. We elucidate two definitions—termed “mean” and “galactic”
α-enhancement—in more detail. While a star-forming galaxy has a high “mean” α-enhancement
when its stars formed rapidly, a galaxy with a large “galactic” α-enhancement
generally had a delayed SFH. We find that absorption-line strengths of Mg and
Fe correlate with variations in α-enhancement. These correlations are strongest
for the “galactic” α-enhancement. However, we show that these are mostly caused
by other effects that are cross-correlated with α-enhancement, such as variations
in the light-weighted age. This severely complicates the retrieval of α-enhancements
in star-forming galaxies. The ambiguity is not severe for passive galaxies, and
we confirm that spectral variations in these galaxies are caused by measurable
variations in α-enhancements. We suggest that this more complex coupling between
α-enhancement and SFHs can guide the interpretation of new observations of star-forming
galaxies.
acknowledgement: "We thank our anonymous referee for the constructive feedback. We
extend our gratitude to Maarten Baes, Simon Lilly, Rafael Ottersberg, Gabriele Pezzulli,
Alvio Renzini, and Andrea Weibel for insightful discussions. A.G. gratefully acknowledges
financial support from the Fund for Scientific Research Flanders (FWO-Vlaanderen,
project G.0G04.16N). This work used the DiRAC Data Centric system at Durham University,
operated by the ICC on behalf of the STFC DiRAC HPC Facility (www.dirac.ac.uk).
This equipment was funded by BIS National E-infrastructure capital grant ST/K00042X/1,
STFC capital grant ST/H008519/1, and STFC DiRAC Operations grant ST/K003267/1 and
Durham University. DiRAC is part of the National E-Infrastructure.\r\n\r\nWe have
benefited from the data analysis tool Topcat (Taylor 2013) and the programming language
Python, including the numpy (van der Walt et al. 2011), matplotlib (Hunter 2007),
and scipy (Virtanen et al. 2020) packages."
article_number: '73'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Andrea
full_name: Gebek, Andrea
last_name: Gebek
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
citation:
ama: Gebek A, Matthee JJ. On the variation in stellar α-enhancements of star-forming
galaxies in the EAGLE simulation. The Astrophysical Journal. 2022;924(2).
doi:10.3847/1538-4357/ac350b
apa: Gebek, A., & Matthee, J. J. (2022). On the variation in stellar α-enhancements
of star-forming galaxies in the EAGLE simulation. The Astrophysical Journal.
IOP Publishing. https://doi.org/10.3847/1538-4357/ac350b
chicago: Gebek, Andrea, and Jorryt J Matthee. “On the Variation in Stellar α-Enhancements
of Star-Forming Galaxies in the EAGLE Simulation.” The Astrophysical Journal.
IOP Publishing, 2022. https://doi.org/10.3847/1538-4357/ac350b.
ieee: A. Gebek and J. J. Matthee, “On the variation in stellar α-enhancements of
star-forming galaxies in the EAGLE simulation,” The Astrophysical Journal,
vol. 924, no. 2. IOP Publishing, 2022.
ista: Gebek A, Matthee JJ. 2022. On the variation in stellar α-enhancements of star-forming
galaxies in the EAGLE simulation. The Astrophysical Journal. 924(2), 73.
mla: Gebek, Andrea, and Jorryt J. Matthee. “On the Variation in Stellar α-Enhancements
of Star-Forming Galaxies in the EAGLE Simulation.” The Astrophysical Journal,
vol. 924, no. 2, 73, IOP Publishing, 2022, doi:10.3847/1538-4357/ac350b.
short: A. Gebek, J.J. Matthee, The Astrophysical Journal 924 (2022).
date_created: 2022-07-06T12:48:32Z
date_published: 2022-01-13T00:00:00Z
date_updated: 2024-10-14T11:31:47Z
day: '13'
doi: 10.3847/1538-4357/ac350b
extern: '1'
external_id:
arxiv:
- '2102.04561'
fulldoi: https://doi.org/10.3847/1538-4357/ac350b
intvolume: ' 924'
issue: '2'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2102.04561
month: '01'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the variation in stellar α-enhancements of star-forming galaxies in the
EAGLE simulation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 924
year: '2022'
...
---
_id: '11521'
abstract:
- lang: eng
text: 'The cosmic ionizing emissivity from star-forming galaxies has long been anchored
to UV luminosity functions. Here, we introduce an emissivity framework based on
Lyα emitters (LAEs), which naturally hones in on the subset of galaxies responsible
for the ionizing background due to the intimate connection between production
and escape of Lyα and LyC photons. Using constraints on the escape fractions of
bright LAEs (LLyα > 0.2L*) at z ≈ 2 obtained from resolved Lyα profiles, and arguing
for their redshift-invariance, we show that: (i) quasars and LAEs together reproduce
the relatively flat emissivity at z ≈ 2–6, which is non-trivial given the strong
evolution in both the star formation density and quasar number density at these
epochs and (ii) LAEs produce late and rapid reionization between z ≈ 6−9 under
plausible assumptions. Within this framework, the >10 × rise in the UV population-averaged
fesc between z ≈ 3–7 naturally arises due to the same phenomena that drive the
growing LAE fraction with redshift. Generally, a LAE dominated emissivity yields
a peak in the distribution of the ionizing budget with UV luminosity as reported
in latest simulations. Using our adopted parameters (fesc=50 per cent, ξion
= 1025.9 Hz erg−1 for half the bright LAEs), a highly ionizing minority of galaxies
with MUV < −17 accounts for the entire ionizing budget from star-forming galaxies.
Rapid flashes of LyC from such rare galaxies produce a ‘disco’ ionizing background.
We conclude proposing tests to further develop our suggested Lyα-anchored formalism.'
acknowledgement: We thank an anonymous referee for an encouraging and constructive
report that helped improving the quality of this work. We acknowledge illuminating
conversations with Xiaohan Wu, Chris Cain, Anna-Christina Eilers, Simon Lilly and
Ruari Mackenzie. RPN gratefully acknowledges an Ashford Fellowship granted by Harvard
University. MG was supported by NASA through the NASA Hubble Fellowship grant HST-HF2-51409.
PO acknowledges support from the Swiss National Science Foundation through the SNSF
Professorship grant 190079. GP acknowledges support from the Netherlands Research
School for Astronomy (NOVA). MH is fellow of the Knut and Alice Wallenberg Foundation.
DE is supported by the US National Science Foundation (NSF) through Astronomy &
Astrophysics grant AST-1909198. The Cosmic Dawn Center (DAWN) is funded by the Danish
National Research Foundation under grant No. 140. RA acknowledges support from Fondecyt
Regular Grant 1202007. ST is supported by the 2021 Research Fund 1.210134.01 of
UNIST (Ulsan National Institute of Science & Technology). MLl acknowledges support
from the ANID/Scholarship Program/Doctorado Nacional/2019-21191036. JC acknowledges
support from the Spanish Ministry of Science and Innovation, project PID2019-107408GB-C43
(ESTALLIDOS) and from Gobierno de Canarias through EU FEDER funding, project PID2020010050.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Rohan P.
full_name: Naidu, Rohan P.
last_name: Naidu
- first_name: Gabriele
full_name: Pezzulli, Gabriele
last_name: Pezzulli
- first_name: Max
full_name: Gronke, Max
last_name: Gronke
- first_name: David
full_name: Sobral, David
last_name: Sobral
- first_name: Pascal A.
full_name: Oesch, Pascal A.
last_name: Oesch
- first_name: Matthew
full_name: Hayes, Matthew
last_name: Hayes
- first_name: Dawn
full_name: Erb, Dawn
last_name: Erb
- first_name: Daniel
full_name: Schaerer, Daniel
last_name: Schaerer
- first_name: Ricardo
full_name: Amorín, Ricardo
last_name: Amorín
- first_name: Sandro
full_name: Tacchella, Sandro
last_name: Tacchella
- first_name: Ana Paulino-Afonso
full_name: Ana Paulino-Afonso, Ana Paulino-Afonso
last_name: Ana Paulino-Afonso
- first_name: Mario
full_name: Llerena, Mario
last_name: Llerena
- first_name: João
full_name: Calhau, João
last_name: Calhau
- first_name: Huub
full_name: Röttgering, Huub
last_name: Röttgering
citation:
ama: 'Matthee JJ, Naidu RP, Pezzulli G, et al. (Re)Solving reionization with Lyα:
How bright Lyα emitters account for the z ≈ 2 − 8 cosmic ionizing background.
Monthly Notices of the Royal Astronomical Society. 2022;512(4):5960-5977.
doi:10.1093/mnras/stac801'
apa: 'Matthee, J. J., Naidu, R. P., Pezzulli, G., Gronke, M., Sobral, D., Oesch,
P. A., … Röttgering, H. (2022). (Re)Solving reionization with Lyα: How bright
Lyα emitters account for the z ≈ 2 − 8 cosmic ionizing background. Monthly
Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/stac801'
chicago: 'Matthee, Jorryt J, Rohan P. Naidu, Gabriele Pezzulli, Max Gronke, David
Sobral, Pascal A. Oesch, Matthew Hayes, et al. “(Re)Solving Reionization with
Lyα: How Bright Lyα Emitters Account for the z ≈ 2 − 8 Cosmic Ionizing Background.”
Monthly Notices of the Royal Astronomical Society. Oxford University Press,
2022. https://doi.org/10.1093/mnras/stac801.'
ieee: 'J. J. Matthee et al., “(Re)Solving reionization with Lyα: How bright
Lyα emitters account for the z ≈ 2 − 8 cosmic ionizing background,” Monthly
Notices of the Royal Astronomical Society, vol. 512, no. 4. Oxford University
Press, pp. 5960–5977, 2022.'
ista: 'Matthee JJ, Naidu RP, Pezzulli G, Gronke M, Sobral D, Oesch PA, Hayes M,
Erb D, Schaerer D, Amorín R, Tacchella S, Ana Paulino-Afonso AP-A, Llerena M,
Calhau J, Röttgering H. 2022. (Re)Solving reionization with Lyα: How bright Lyα
emitters account for the z ≈ 2 − 8 cosmic ionizing background. Monthly Notices
of the Royal Astronomical Society. 512(4), 5960–5977.'
mla: 'Matthee, Jorryt J., et al. “(Re)Solving Reionization with Lyα: How Bright
Lyα Emitters Account for the z ≈ 2 − 8 Cosmic Ionizing Background.” Monthly
Notices of the Royal Astronomical Society, vol. 512, no. 4, Oxford University
Press, 2022, pp. 5960–77, doi:10.1093/mnras/stac801.'
short: J.J. Matthee, R.P. Naidu, G. Pezzulli, M. Gronke, D. Sobral, P.A. Oesch,
M. Hayes, D. Erb, D. Schaerer, R. Amorín, S. Tacchella, A.P.-A. Ana Paulino-Afonso,
M. Llerena, J. Calhau, H. Röttgering, Monthly Notices of the Royal Astronomical
Society 512 (2022) 5960–5977.
date_created: 2022-07-07T09:21:30Z
date_published: 2022-06-01T00:00:00Z
date_updated: 2024-10-14T11:32:26Z
day: '01'
doi: 10.1093/mnras/stac801
extern: '1'
external_id:
arxiv:
- '2110.11967'
fulldoi: https://doi.org/10.1093/mnras/stac801
intvolume: ' 512'
issue: '4'
keyword:
- 'galaxies: high-redshift'
- intergalactic medium
- 'cosmology: observations'
- dark ages
- reionization
- first stars
- 'ultraviolet: galaxies'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2110.11967
month: '06'
oa: 1
oa_version: Preprint
page: 5960-5977
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: '(Re)Solving reionization with Lyα: How bright Lyα emitters account for the
z ≈ 2 − 8 cosmic ionizing background'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 512
year: '2022'
...
---
_id: '11542'
article_processing_charge: No
author:
- first_name: Rouven
full_name: Schulz, Rouven
id: 4C5E7B96-F248-11E8-B48F-1D18A9856A87
last_name: Schulz
orcid: 0000-0001-5297-733X
citation:
ama: Schulz R. Source Data (Chimeric GPCRs mimic distinct signaling pathways and
modulate microglia responses). 2022. doi:10.15479/AT:ISTA:11542
apa: Schulz, R. (2022). Source Data (Chimeric GPCRs mimic distinct signaling pathways
and modulate microglia responses). Institute of Science and Technology Austria.
https://doi.org/10.15479/AT:ISTA:11542
chicago: Schulz, Rouven. “Source Data (Chimeric GPCRs Mimic Distinct Signaling Pathways
and Modulate Microglia Responses).” Institute of Science and Technology Austria,
2022. https://doi.org/10.15479/AT:ISTA:11542.
ieee: R. Schulz, “Source Data (Chimeric GPCRs mimic distinct signaling pathways
and modulate microglia responses).” Institute of Science and Technology Austria,
2022.
ista: Schulz R. 2022. Source Data (Chimeric GPCRs mimic distinct signaling pathways
and modulate microglia responses), Institute of Science and Technology Austria,
10.15479/AT:ISTA:11542.
mla: Schulz, Rouven. Source Data (Chimeric GPCRs Mimic Distinct Signaling Pathways
and Modulate Microglia Responses). Institute of Science and Technology Austria,
2022, doi:10.15479/AT:ISTA:11542.
short: R. Schulz, (2022).
contributor:
- contributor_type: contact_person
first_name: Sandra
id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
last_name: Siegert
orcid: 0000-0001-8635-0877
corr_author: '1'
date_created: 2022-07-08T11:03:02Z
date_published: 2022-01-01T00:00:00Z
date_updated: 2025-04-15T07:27:21Z
department:
- _id: GradSch
- _id: SaSi
doi: 10.15479/AT:ISTA:11542
file:
- access_level: open_access
checksum: 71e8186583f3adbb6c69a88ac9e6e49b
content_type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
creator: rschulz
date_created: 2022-07-08T10:56:52Z
date_updated: 2022-07-08T10:56:52Z
file_id: '11543'
file_name: Source Data.xlsx
file_size: 135784571
relation: main_file
success: 1
file_date_updated: 2022-07-08T10:56:52Z
fulldoi: https://doi.org/10.15479/AT:ISTA:11542
has_accepted_license: '1'
oa: 1
oa_version: None
publisher: Institute of Science and Technology Austria
related_material:
link:
- relation: contains
url: https://www.biorxiv.org/content/10.1101/2021.06.21.449162v1
record:
- id: '11995'
relation: used_in_publication
status: public
status: public
title: Source Data (Chimeric GPCRs mimic distinct signaling pathways and modulate
microglia responses)
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '11545'
abstract:
- lang: eng
text: "We classify contravariant pairings between standard Whittaker modules and
Verma modules over a complex semisimple Lie algebra. These contravariant pairings
are useful in extending several classical techniques for category O to the Miličić–Soergel
category N . We introduce a class of costandard modules which generalize dual
Verma modules, and describe canonical maps from standard to costandard modules
in terms of contravariant pairings.\r\nWe show that costandard modules have unique
irreducible submodules and share the same composition factors as the corresponding
standard Whittaker modules. We show that costandard modules give an algebraic
characterization of the global sections of costandard twisted Harish-Chandra sheaves
on the associated flag variety, which are defined using holonomic duality of D-modules.
We prove that with these costandard modules, blocks of category\r\nN have the
structure of highest weight categories and we establish a BGG reciprocity theorem
for N ."
acknowledgement: We thank Catharina Stroppel and Jens Niklas Eberhardt for interesting
discussions. The first author acknowledges the support of the European Union's Horizon
2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement
No. 754411. The second author is supported by the National Science Foundation Award
No. 1803059 and the Australian Research Council grant DP170101579.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Adam
full_name: Brown, Adam
id: 70B7FDF6-608D-11E9-9333-8535E6697425
last_name: Brown
- first_name: Anna
full_name: Romanov, Anna
last_name: Romanov
citation:
ama: Brown A, Romanov A. Contravariant pairings between standard Whittaker modules
and Verma modules. Journal of Algebra. 2022;609(11):145-179. doi:10.1016/j.jalgebra.2022.06.017
apa: Brown, A., & Romanov, A. (2022). Contravariant pairings between standard
Whittaker modules and Verma modules. Journal of Algebra. Elsevier. https://doi.org/10.1016/j.jalgebra.2022.06.017
chicago: Brown, Adam, and Anna Romanov. “Contravariant Pairings between Standard
Whittaker Modules and Verma Modules.” Journal of Algebra. Elsevier, 2022.
https://doi.org/10.1016/j.jalgebra.2022.06.017.
ieee: A. Brown and A. Romanov, “Contravariant pairings between standard Whittaker
modules and Verma modules,” Journal of Algebra, vol. 609, no. 11. Elsevier,
pp. 145–179, 2022.
ista: Brown A, Romanov A. 2022. Contravariant pairings between standard Whittaker
modules and Verma modules. Journal of Algebra. 609(11), 145–179.
mla: Brown, Adam, and Anna Romanov. “Contravariant Pairings between Standard Whittaker
Modules and Verma Modules.” Journal of Algebra, vol. 609, no. 11, Elsevier,
2022, pp. 145–79, doi:10.1016/j.jalgebra.2022.06.017.
short: A. Brown, A. Romanov, Journal of Algebra 609 (2022) 145–179.
corr_author: '1'
date_created: 2022-07-08T11:40:07Z
date_published: 2022-11-01T00:00:00Z
date_updated: 2025-04-14T07:43:58Z
day: '01'
ddc:
- '510'
department:
- _id: HeEd
doi: 10.1016/j.jalgebra.2022.06.017
ec_funded: 1
external_id:
isi:
- '000861841100004'
file:
- access_level: open_access
checksum: 82abaee3d7837f703e499a9ecbb25b7c
content_type: application/pdf
creator: dernst
date_created: 2023-02-02T07:32:48Z
date_updated: 2023-02-02T07:32:48Z
file_id: '12473'
file_name: 2022_JournalAlgebra_Brown.pdf
file_size: 582962
relation: main_file
success: 1
file_date_updated: 2023-02-02T07:32:48Z
fulldoi: https://doi.org/10.1016/j.jalgebra.2022.06.017
has_accepted_license: '1'
intvolume: ' 609'
isi: 1
issue: '11'
keyword:
- Algebra and Number Theory
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 145-179
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Journal of Algebra
publication_identifier:
issn:
- 0021-8693
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Contravariant pairings between standard Whittaker modules and Verma modules
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 609
year: '2022'
...
---
_id: '11546'
abstract:
- lang: eng
text: Local adaptation leads to differences between populations within a species.
In many systems, similar environmental contrasts occur repeatedly, sometimes driving
parallel phenotypic evolution. Understanding the genomic basis of local adaptation
and parallel evolution is a major goal of evolutionary genomics. It is now known
that by preventing the break-up of favourable combinations of alleles across multiple
loci, genetic architectures that reduce recombination, like chromosomal inversions,
can make an important contribution to local adaptation. However, little is known
about whether inversions also contribute disproportionately to parallel evolution.
Our aim here is to highlight this knowledge gap, to showcase existing studies,
and to illustrate the differences between genomic architectures with and without
inversions using simple models. We predict that by generating stronger effective
selection, inversions can sometimes speed up the parallel adaptive process or
enable parallel adaptation where it would be impossible otherwise, but this is
highly dependent on the spatial setting. We highlight that further empirical work
is needed, in particular to cover a broader taxonomic range and to understand
the relative importance of inversions compared to genomic regions without inversions.
acknowledgement: We thank the editor and two anonymous reviewers for their helpful
and interesting comments on this manuscript.
article_number: '20210203'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
- first_name: Rui
full_name: Faria, Rui
last_name: Faria
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
- first_name: Roger
full_name: Butlin, Roger
last_name: Butlin
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Westram AM, Faria R, Johannesson K, Butlin R, Barton NH. Inversions and parallel
evolution. Philosophical Transactions of the Royal Society B: Biological Sciences.
2022;377(1856). doi:10.1098/rstb.2021.0203'
apa: 'Westram, A. M., Faria, R., Johannesson, K., Butlin, R., & Barton, N. H.
(2022). Inversions and parallel evolution. Philosophical Transactions of the
Royal Society B: Biological Sciences. Royal Society of London. https://doi.org/10.1098/rstb.2021.0203'
chicago: 'Westram, Anja M, Rui Faria, Kerstin Johannesson, Roger Butlin, and Nicholas
H Barton. “Inversions and Parallel Evolution.” Philosophical Transactions of
the Royal Society B: Biological Sciences. Royal Society of London, 2022. https://doi.org/10.1098/rstb.2021.0203.'
ieee: 'A. M. Westram, R. Faria, K. Johannesson, R. Butlin, and N. H. Barton, “Inversions
and parallel evolution,” Philosophical Transactions of the Royal Society B:
Biological Sciences, vol. 377, no. 1856. Royal Society of London, 2022.'
ista: 'Westram AM, Faria R, Johannesson K, Butlin R, Barton NH. 2022. Inversions
and parallel evolution. Philosophical Transactions of the Royal Society B: Biological
Sciences. 377(1856), 20210203.'
mla: 'Westram, Anja M., et al. “Inversions and Parallel Evolution.” Philosophical
Transactions of the Royal Society B: Biological Sciences, vol. 377, no. 1856,
20210203, Royal Society of London, 2022, doi:10.1098/rstb.2021.0203.'
short: 'A.M. Westram, R. Faria, K. Johannesson, R. Butlin, N.H. Barton, Philosophical
Transactions of the Royal Society B: Biological Sciences 377 (2022).'
corr_author: '1'
date_created: 2022-07-08T11:41:56Z
date_published: 2022-08-01T00:00:00Z
date_updated: 2025-06-12T06:10:18Z
day: '01'
ddc:
- '570'
department:
- _id: BeVi
- _id: NiBa
doi: 10.1098/rstb.2021.0203
external_id:
isi:
- '000812317300005'
pmid:
- '35694747'
file:
- access_level: open_access
checksum: 49f69428f3dcf5ce3ff281f7d199e9df
content_type: application/pdf
creator: dernst
date_created: 2023-02-02T08:20:29Z
date_updated: 2023-02-02T08:20:29Z
file_id: '12479'
file_name: 2022_PhilosophicalTransactionsB_Westram.pdf
file_size: 920304
relation: main_file
success: 1
file_date_updated: 2023-02-02T08:20:29Z
fulldoi: https://doi.org/10.1098/rstb.2021.0203
has_accepted_license: '1'
intvolume: ' 377'
isi: 1
issue: '1856'
keyword:
- General Agricultural and Biological Sciences
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 05959E1C-7A3F-11EA-A408-12923DDC885E
grant_number: P32166
name: Snapdragon Speciation
publication: 'Philosophical Transactions of the Royal Society B: Biological Sciences'
publication_identifier:
eissn:
- 1471-2970
issn:
- 0962-8436
publication_status: published
publisher: Royal Society of London
quality_controlled: '1'
scopus_import: '1'
status: public
title: Inversions and parallel evolution
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 377
year: '2022'
...
---
_id: '11551'
abstract:
- lang: eng
text: Imbalanced mitochondrial dNTP pools are known players in the pathogenesis
of multiple human diseases. Here we show that, even under physiological conditions,
dGTP is largely overrepresented among other dNTPs in mitochondria of mouse tissues
and human cultured cells. In addition, a vast majority of mitochondrial dGTP is
tightly bound to NDUFA10, an accessory subunit of complex I of the mitochondrial
respiratory chain. NDUFA10 shares a deoxyribonucleoside kinase (dNK) domain with
deoxyribonucleoside kinases in the nucleotide salvage pathway, though no specific
function beyond stabilizing the complex I holoenzyme has been described for this
subunit. We mutated the dNK domain of NDUFA10 in human HEK-293T cells while preserving
complex I assembly and activity. The NDUFA10E160A/R161A shows reduced dGTP binding
capacity in vitro and leads to a 50% reduction in mitochondrial dGTP content,
proving that most dGTP is directly bound to the dNK domain of NDUFA10. This interaction
may represent a hitherto unknown mechanism regulating mitochondrial dNTP availability
and linking oxidative metabolism to DNA maintenance.
acknowledgement: "We thank Dr, Luke Formosa (Department of Biochemistry and Molecular
Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia)
for his valuable advice and assistance on NDUFA10 molecular studies and Dr. Francesc
Canals and his team (Proteomics Laboratory, Vall d’Hebron Institute of Oncology
[VHIO], Universitat Autònoma de Barcelona, Barcelona, Spain) for their assistance
with LC-MS/MS analyses. This work was supported by the Spanish Ministry of Industry,
Economy and Competitiveness [grants BFU2014-52618-R, SAF2017-87506, and PID2020-112929RB-I00
to Y.C.], by the Spanish Instituto de Salud Carlos III [grants PI21/00554 and PMP15/00025
to R.M.], co-financed by the European Regional Development Fund (ERDF), and by an
NHMRC Project grant to M.R. (GNT1164459).\r\n"
article_number: '620'
article_processing_charge: No
author:
- first_name: David
full_name: Molina-Granada, David
last_name: Molina-Granada
- first_name: Emiliano
full_name: González-Vioque, Emiliano
last_name: González-Vioque
- first_name: Marris G.
full_name: Dibley, Marris G.
last_name: Dibley
- first_name: Raquel
full_name: Cabrera-Pérez, Raquel
last_name: Cabrera-Pérez
- first_name: Antoni
full_name: Vallbona-Garcia, Antoni
last_name: Vallbona-Garcia
- first_name: Javier
full_name: Torres-Torronteras, Javier
last_name: Torres-Torronteras
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
- first_name: Michael T.
full_name: Ryan, Michael T.
last_name: Ryan
- first_name: Yolanda
full_name: Cámara, Yolanda
last_name: Cámara
- first_name: Ramon
full_name: Martí, Ramon
last_name: Martí
citation:
ama: Molina-Granada D, González-Vioque E, Dibley MG, et al. Most mitochondrial dGTP
is tightly bound to respiratory complex I through the NDUFA10 subunit. Communications
Biology. 2022;5(1). doi:10.1038/s42003-022-03568-6
apa: Molina-Granada, D., González-Vioque, E., Dibley, M. G., Cabrera-Pérez, R.,
Vallbona-Garcia, A., Torres-Torronteras, J., … Martí, R. (2022). Most mitochondrial
dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit. Communications
Biology. Springer Nature. https://doi.org/10.1038/s42003-022-03568-6
chicago: Molina-Granada, David, Emiliano González-Vioque, Marris G. Dibley, Raquel
Cabrera-Pérez, Antoni Vallbona-Garcia, Javier Torres-Torronteras, Leonid A Sazanov,
Michael T. Ryan, Yolanda Cámara, and Ramon Martí. “Most Mitochondrial DGTP Is
Tightly Bound to Respiratory Complex I through the NDUFA10 Subunit.” Communications
Biology. Springer Nature, 2022. https://doi.org/10.1038/s42003-022-03568-6.
ieee: D. Molina-Granada et al., “Most mitochondrial dGTP is tightly bound
to respiratory complex I through the NDUFA10 subunit,” Communications Biology,
vol. 5, no. 1. Springer Nature, 2022.
ista: Molina-Granada D, González-Vioque E, Dibley MG, Cabrera-Pérez R, Vallbona-Garcia
A, Torres-Torronteras J, Sazanov LA, Ryan MT, Cámara Y, Martí R. 2022. Most mitochondrial
dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit. Communications
Biology. 5(1), 620.
mla: Molina-Granada, David, et al. “Most Mitochondrial DGTP Is Tightly Bound to
Respiratory Complex I through the NDUFA10 Subunit.” Communications Biology,
vol. 5, no. 1, 620, Springer Nature, 2022, doi:10.1038/s42003-022-03568-6.
short: D. Molina-Granada, E. González-Vioque, M.G. Dibley, R. Cabrera-Pérez, A.
Vallbona-Garcia, J. Torres-Torronteras, L.A. Sazanov, M.T. Ryan, Y. Cámara, R.
Martí, Communications Biology 5 (2022).
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