---
_id: '12277'
abstract:
- lang: eng
  text: Cell migration in confining physiological environments relies on the concerted
    dynamics of several cellular components, including protrusions, adhesions with
    the environment, and the cell nucleus. However, it remains poorly understood how
    the dynamic interplay of these components and the cell polarity determine the
    emergent migration behavior at the cellular scale. Here, we combine data-driven
    inference with a mechanistic bottom-up approach to develop a model for protrusion
    and polarity dynamics in confined cell migration, revealing how the cellular dynamics
    adapt to confining geometries. Specifically, we use experimental data of joint
    protrusion-nucleus migration trajectories of cells on confining micropatterns
    to systematically determine a mechanistic model linking the stochastic dynamics
    of cell polarity, protrusions, and nucleus. This model indicates that the cellular
    dynamics adapt to confining constrictions through a switch in the polarity dynamics
    from a negative to a positive self-reinforcing feedback loop. Our model further
    reveals how this feedback loop leads to stereotypical cycles of protrusion-nucleus
    dynamics that drive the migration of the cell through constrictions. These cycles
    are disrupted upon perturbation of cytoskeletal components, indicating that the
    positive feedback is controlled by cellular migration mechanisms. Our data-driven
    theoretical approach therefore identifies polarity feedback adaptation as a key
    mechanism in confined cell migration.
acknowledgement: "We thank Grzegorz Gradziuk, StevenRiedijk, Janni Harju, and M. R.
  Schnucki for helpful discussions, and Andriy Goychuk for advice on the image segmentation.
  This project\r\nwas funded by the Deutsche Forschungsgemeinschaft (DFG, German Research
  Foundation), Project No. 201269156—SFB 1032 (Projects B01 and B12). D. B. B. is
  supported by the NOMIS Foundation and in part by a DFG fellowship within the Graduate
  School of Quantitative Biosciences Munich (QBM), as well as by the Joachim Herz
  Stiftung."
article_number: '031041'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: David
  full_name: Brückner, David
  id: e1e86031-6537-11eb-953a-f7ab92be508d
  last_name: Brückner
  orcid: 0000-0001-7205-2975
- first_name: Matthew
  full_name: Schmitt, Matthew
  last_name: Schmitt
- first_name: Alexandra
  full_name: Fink, Alexandra
  last_name: Fink
- first_name: Georg
  full_name: Ladurner, Georg
  last_name: Ladurner
- first_name: Johannes
  full_name: Flommersfeld, Johannes
  last_name: Flommersfeld
- first_name: Nicolas
  full_name: Arlt, Nicolas
  last_name: Arlt
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Joachim O.
  full_name: Rädler, Joachim O.
  last_name: Rädler
- first_name: Chase P.
  full_name: Broedersz, Chase P.
  last_name: Broedersz
citation:
  ama: Brückner D, Schmitt M, Fink A, et al. Geometry adaptation of protrusion and
    polarity dynamics in confined cell migration. <i>Physical Review X</i>. 2022;12(3).
    doi:<a href="https://doi.org/10.1103/physrevx.12.031041">10.1103/physrevx.12.031041</a>
  apa: Brückner, D., Schmitt, M., Fink, A., Ladurner, G., Flommersfeld, J., Arlt,
    N., … Broedersz, C. P. (2022). Geometry adaptation of protrusion and polarity
    dynamics in confined cell migration. <i>Physical Review X</i>. American Physical
    Society. <a href="https://doi.org/10.1103/physrevx.12.031041">https://doi.org/10.1103/physrevx.12.031041</a>
  chicago: Brückner, David, Matthew Schmitt, Alexandra Fink, Georg Ladurner, Johannes
    Flommersfeld, Nicolas Arlt, Edouard B Hannezo, Joachim O. Rädler, and Chase P.
    Broedersz. “Geometry Adaptation of Protrusion and Polarity Dynamics in Confined
    Cell Migration.” <i>Physical Review X</i>. American Physical Society, 2022. <a
    href="https://doi.org/10.1103/physrevx.12.031041">https://doi.org/10.1103/physrevx.12.031041</a>.
  ieee: D. Brückner <i>et al.</i>, “Geometry adaptation of protrusion and polarity
    dynamics in confined cell migration,” <i>Physical Review X</i>, vol. 12, no. 3.
    American Physical Society, 2022.
  ista: Brückner D, Schmitt M, Fink A, Ladurner G, Flommersfeld J, Arlt N, Hannezo
    EB, Rädler JO, Broedersz CP. 2022. Geometry adaptation of protrusion and polarity
    dynamics in confined cell migration. Physical Review X. 12(3), 031041.
  mla: Brückner, David, et al. “Geometry Adaptation of Protrusion and Polarity Dynamics
    in Confined Cell Migration.” <i>Physical Review X</i>, vol. 12, no. 3, 031041,
    American Physical Society, 2022, doi:<a href="https://doi.org/10.1103/physrevx.12.031041">10.1103/physrevx.12.031041</a>.
  short: D. Brückner, M. Schmitt, A. Fink, G. Ladurner, J. Flommersfeld, N. Arlt,
    E.B. Hannezo, J.O. Rädler, C.P. Broedersz, Physical Review X 12 (2022).
date_created: 2023-01-16T10:02:06Z
date_published: 2022-09-20T00:00:00Z
date_updated: 2023-08-04T10:25:49Z
day: '20'
ddc:
- '530'
- '570'
department:
- _id: EdHa
doi: 10.1103/physrevx.12.031041
external_id:
  arxiv:
  - '2106.01014'
  isi:
  - '000861534700001'
file:
- access_level: open_access
  checksum: 40a8fbc3663bf07b37cb80020974d40d
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-30T11:07:27Z
  date_updated: 2023-01-30T11:07:27Z
  file_id: '12458'
  file_name: 2022_PhysicalReviewX_Brueckner.pdf
  file_size: 4686804
  relation: main_file
  success: 1
file_date_updated: 2023-01-30T11:07:27Z
fulldoi: https://doi.org/10.1103/physrevx.12.031041
has_accepted_license: '1'
intvolume: '        12'
isi: 1
issue: '3'
keyword:
- General Physics and Astronomy
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
publication: Physical Review X
publication_identifier:
  issn:
  - 2160-3308
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Geometry adaptation of protrusion and polarity dynamics in confined cell migration
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 12
year: '2022'
...
---
_id: '12278'
abstract:
- lang: eng
  text: Mercury telluride (HgTe) thin films with a critical thickness of 6.5 nm are
    predicted to possess a gapless Dirac-like band structure. We report a comprehensive
    study on gated and optically doped samples by magnetooptical spectroscopy in the
    THz range. The quasi-classical analysis of the cyclotron resonance allowed the
    mapping of the band dispersion of Dirac charge carriers in a broad range of electron
    and hole doping. A smooth transition through the charge neutrality point between
    Dirac holes and electrons was observed. An additional peak coming from a second
    type of holes with an almost density-independent mass of around 0.04m0 was detected
    in the hole-doping range and attributed to an asymmetric spin splitting of the
    Dirac cone. Spectroscopic evidence for disorder-induced band energy fluctuations
    could not be detected in present cyclotron resonance experiments.
acknowledgement: "This work was supported by the Austrian Science Funds (W1243, I
  3456-N27, I 5539-N).\r\nOpen Access Funding by the Austrian Science Fund (FWF)."
article_number: '2492'
article_processing_charge: Yes
article_type: original
author:
- first_name: Alexey
  full_name: Shuvaev, Alexey
  last_name: Shuvaev
- first_name: Uladzislau
  full_name: Dziom, Uladzislau
  id: 6A9A37C2-8C5C-11E9-AE53-F2FDE5697425
  last_name: Dziom
  orcid: 0000-0002-1648-0999
- first_name: Jan
  full_name: Gospodarič, Jan
  last_name: Gospodarič
- first_name: Elena G.
  full_name: Novik, Elena G.
  last_name: Novik
- first_name: Alena A.
  full_name: Dobretsova, Alena A.
  last_name: Dobretsova
- first_name: Nikolay N.
  full_name: Mikhailov, Nikolay N.
  last_name: Mikhailov
- first_name: Ze Don
  full_name: Kvon, Ze Don
  last_name: Kvon
- first_name: Andrei
  full_name: Pimenov, Andrei
  last_name: Pimenov
citation:
  ama: Shuvaev A, Dziom V, Gospodarič J, et al. Band structure near the Dirac Point
    in HgTe quantum wells with critical thickness. <i>Nanomaterials</i>. 2022;12(14).
    doi:<a href="https://doi.org/10.3390/nano12142492">10.3390/nano12142492</a>
  apa: Shuvaev, A., Dziom, V., Gospodarič, J., Novik, E. G., Dobretsova, A. A., Mikhailov,
    N. N., … Pimenov, A. (2022). Band structure near the Dirac Point in HgTe quantum
    wells with critical thickness. <i>Nanomaterials</i>. MDPI. <a href="https://doi.org/10.3390/nano12142492">https://doi.org/10.3390/nano12142492</a>
  chicago: Shuvaev, Alexey, Vlad Dziom, Jan Gospodarič, Elena G. Novik, Alena A. Dobretsova,
    Nikolay N. Mikhailov, Ze Don Kvon, and Andrei Pimenov. “Band Structure near the
    Dirac Point in HgTe Quantum Wells with Critical Thickness.” <i>Nanomaterials</i>.
    MDPI, 2022. <a href="https://doi.org/10.3390/nano12142492">https://doi.org/10.3390/nano12142492</a>.
  ieee: A. Shuvaev <i>et al.</i>, “Band structure near the Dirac Point in HgTe quantum
    wells with critical thickness,” <i>Nanomaterials</i>, vol. 12, no. 14. MDPI, 2022.
  ista: Shuvaev A, Dziom V, Gospodarič J, Novik EG, Dobretsova AA, Mikhailov NN, Kvon
    ZD, Pimenov A. 2022. Band structure near the Dirac Point in HgTe quantum wells
    with critical thickness. Nanomaterials. 12(14), 2492.
  mla: Shuvaev, Alexey, et al. “Band Structure near the Dirac Point in HgTe Quantum
    Wells with Critical Thickness.” <i>Nanomaterials</i>, vol. 12, no. 14, 2492, MDPI,
    2022, doi:<a href="https://doi.org/10.3390/nano12142492">10.3390/nano12142492</a>.
  short: A. Shuvaev, V. Dziom, J. Gospodarič, E.G. Novik, A.A. Dobretsova, N.N. Mikhailov,
    Z.D. Kvon, A. Pimenov, Nanomaterials 12 (2022).
date_created: 2023-01-16T10:02:31Z
date_published: 2022-07-20T00:00:00Z
date_updated: 2025-06-11T13:45:36Z
day: '20'
ddc:
- '530'
department:
- _id: ZhAl
doi: 10.3390/nano12142492
external_id:
  isi:
  - '000834401600001'
  pmid:
  - '35889716'
file:
- access_level: open_access
  checksum: efad6742f89f39a18bec63116dd689a0
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-30T11:16:54Z
  date_updated: 2023-01-30T11:16:54Z
  file_id: '12459'
  file_name: 2022_Nanomaterials_Shuvaev.pdf
  file_size: 464840
  relation: main_file
  success: 1
file_date_updated: 2023-01-30T11:16:54Z
fulldoi: https://doi.org/10.3390/nano12142492
has_accepted_license: '1'
intvolume: '        12'
isi: 1
issue: '14'
keyword:
- General Materials Science
- General Chemical Engineering
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nanomaterials
publication_identifier:
  issn:
  - 2079-4991
publication_status: published
publisher: MDPI
quality_controlled: '1'
scopus_import: '1'
status: public
title: Band structure near the Dirac Point in HgTe quantum wells with critical thickness
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2022'
...
---
_id: '12279'
abstract:
- lang: eng
  text: We report frictional drag reduction and a complete flow relaminarization of
    elastic turbulence (ET) at vanishing inertia in a viscoelastic channel flow past
    an obstacle. We show that the intensity of the observed elastic waves and wall-normal
    vorticity correlate well with the measured drag above the onset of ET. Moreover,
    we find that the elastic wave frequency grows with the Weissenberg number, and
    at sufficiently high frequency it causes a decay of the elastic waves, resulting
    in ET attenuation and drag reduction. Thus, this allows us to substantiate a physical
    mechanism, involving the interaction of elastic waves with wall-normal vorticity
    fluctuations, leading to the drag reduction and relaminarization phenomena at
    low Reynolds number.
acknowledgement: "We thank G. Falkovich for discussion and Guy Han for technical support.
  We are grateful to N. Jha for his help in µPIV measurements. This work is partially
  supported by the grants from\r\nIsrael Science Foundation (ISF; grant #882/15 and
  grant #784/19) and Binational USA-Israel Foundation (BSF;grant #2016145). "
article_number: L081301
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: M. Vijay
  full_name: Kumar, M. Vijay
  last_name: Kumar
- first_name: Atul
  full_name: Varshney, Atul
  id: 2A2006B2-F248-11E8-B48F-1D18A9856A87
  last_name: Varshney
  orcid: 0000-0002-3072-5999
- first_name: Dongyang
  full_name: Li, Dongyang
  last_name: Li
- first_name: Victor
  full_name: Steinberg, Victor
  last_name: Steinberg
citation:
  ama: Kumar MV, Varshney A, Li D, Steinberg V. Relaminarization of elastic turbulence.
    <i>Physical Review Fluids</i>. 2022;7(8). doi:<a href="https://doi.org/10.1103/physrevfluids.7.l081301">10.1103/physrevfluids.7.l081301</a>
  apa: Kumar, M. V., Varshney, A., Li, D., &#38; Steinberg, V. (2022). Relaminarization
    of elastic turbulence. <i>Physical Review Fluids</i>. American Physical Society.
    <a href="https://doi.org/10.1103/physrevfluids.7.l081301">https://doi.org/10.1103/physrevfluids.7.l081301</a>
  chicago: Kumar, M. Vijay, Atul Varshney, Dongyang Li, and Victor Steinberg. “Relaminarization
    of Elastic Turbulence.” <i>Physical Review Fluids</i>. American Physical Society,
    2022. <a href="https://doi.org/10.1103/physrevfluids.7.l081301">https://doi.org/10.1103/physrevfluids.7.l081301</a>.
  ieee: M. V. Kumar, A. Varshney, D. Li, and V. Steinberg, “Relaminarization of elastic
    turbulence,” <i>Physical Review Fluids</i>, vol. 7, no. 8. American Physical Society,
    2022.
  ista: Kumar MV, Varshney A, Li D, Steinberg V. 2022. Relaminarization of elastic
    turbulence. Physical Review Fluids. 7(8), L081301.
  mla: Kumar, M. Vijay, et al. “Relaminarization of Elastic Turbulence.” <i>Physical
    Review Fluids</i>, vol. 7, no. 8, L081301, American Physical Society, 2022, doi:<a
    href="https://doi.org/10.1103/physrevfluids.7.l081301">10.1103/physrevfluids.7.l081301</a>.
  short: M.V. Kumar, A. Varshney, D. Li, V. Steinberg, Physical Review Fluids 7 (2022).
corr_author: '1'
date_created: 2023-01-16T10:02:40Z
date_published: 2022-08-03T00:00:00Z
date_updated: 2024-10-09T21:03:55Z
day: '03'
department:
- _id: BjHo
doi: 10.1103/physrevfluids.7.l081301
external_id:
  arxiv:
  - '2205.12871'
  isi:
  - '000836397000001'
fulldoi: https://doi.org/10.1103/physrevfluids.7.l081301
intvolume: '         7'
isi: 1
issue: '8'
keyword:
- Fluid Flow and Transfer Processes
- Modeling and Simulation
- Computational Mechanics
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: ' https://doi.org/10.48550/arXiv.2205.12871'
month: '08'
oa: 1
oa_version: Preprint
publication: Physical Review Fluids
publication_identifier:
  issn:
  - 2469-990X
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Relaminarization of elastic turbulence
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 7
year: '2022'
...
---
_id: '12280'
abstract:
- lang: eng
  text: 'In repeated interactions, players can use strategies that respond to the
    outcome of previous rounds. Much of the existing literature on direct reciprocity
    assumes that all competing individuals use the same strategy space. Here, we study
    both learning and evolutionary dynamics of players that differ in the strategy
    space they explore. We focus on the infinitely repeated donation game and compare
    three natural strategy spaces: memory-1 strategies, which consider the last moves
    of both players, reactive strategies, which respond to the last move of the co-player,
    and unconditional strategies. These three strategy spaces differ in the memory
    capacity that is needed. We compute the long term average payoff that is achieved
    in a pairwise learning process. We find that smaller strategy spaces can dominate
    larger ones. For weak selection, unconditional players dominate both reactive
    and memory-1 players. For intermediate selection, reactive players dominate memory-1
    players. Only for strong selection and low cost-to-benefit ratio, memory-1 players
    dominate the others. We observe that the supergame between strategy spaces can
    be a social dilemma: maximum payoff is achieved if both players explore a larger
    strategy space, but smaller strategy spaces dominate.'
acknowledgement: "This work was supported by the European Research Council (https://erc.europa.eu/)\r\nCoG
  863818 (ForM-SMArt) (to K.C.), and the European Research Council Starting Grant
  850529: E-DIRECT (to C.H.). The funders had no role in study design, data collection
  and analysis, decision to publish, or preparation of the manuscript."
article_number: e1010149
article_processing_charge: No
article_type: original
author:
- first_name: Laura
  full_name: Schmid, Laura
  id: 38B437DE-F248-11E8-B48F-1D18A9856A87
  last_name: Schmid
  orcid: 0000-0002-6978-7329
- first_name: Christian
  full_name: Hilbe, Christian
  id: 2FDF8F3C-F248-11E8-B48F-1D18A9856A87
  last_name: Hilbe
  orcid: 0000-0001-5116-955X
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Martin
  full_name: Nowak, Martin
  last_name: Nowak
citation:
  ama: Schmid L, Hilbe C, Chatterjee K, Nowak M. Direct reciprocity between individuals
    that use different strategy spaces. <i>PLOS Computational Biology</i>. 2022;18(6).
    doi:<a href="https://doi.org/10.1371/journal.pcbi.1010149">10.1371/journal.pcbi.1010149</a>
  apa: Schmid, L., Hilbe, C., Chatterjee, K., &#38; Nowak, M. (2022). Direct reciprocity
    between individuals that use different strategy spaces. <i>PLOS Computational
    Biology</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pcbi.1010149">https://doi.org/10.1371/journal.pcbi.1010149</a>
  chicago: Schmid, Laura, Christian Hilbe, Krishnendu Chatterjee, and Martin Nowak.
    “Direct Reciprocity between Individuals That Use Different Strategy Spaces.” <i>PLOS
    Computational Biology</i>. Public Library of Science, 2022. <a href="https://doi.org/10.1371/journal.pcbi.1010149">https://doi.org/10.1371/journal.pcbi.1010149</a>.
  ieee: L. Schmid, C. Hilbe, K. Chatterjee, and M. Nowak, “Direct reciprocity between
    individuals that use different strategy spaces,” <i>PLOS Computational Biology</i>,
    vol. 18, no. 6. Public Library of Science, 2022.
  ista: Schmid L, Hilbe C, Chatterjee K, Nowak M. 2022. Direct reciprocity between
    individuals that use different strategy spaces. PLOS Computational Biology. 18(6),
    e1010149.
  mla: Schmid, Laura, et al. “Direct Reciprocity between Individuals That Use Different
    Strategy Spaces.” <i>PLOS Computational Biology</i>, vol. 18, no. 6, e1010149,
    Public Library of Science, 2022, doi:<a href="https://doi.org/10.1371/journal.pcbi.1010149">10.1371/journal.pcbi.1010149</a>.
  short: L. Schmid, C. Hilbe, K. Chatterjee, M. Nowak, PLOS Computational Biology
    18 (2022).
corr_author: '1'
date_created: 2023-01-16T10:02:51Z
date_published: 2022-06-14T00:00:00Z
date_updated: 2025-04-14T07:52:47Z
day: '14'
ddc:
- '000'
- '570'
department:
- _id: KrCh
doi: 10.1371/journal.pcbi.1010149
ec_funded: 1
external_id:
  isi:
  - '000843626800031'
  pmid:
  - '35700167'
file:
- access_level: open_access
  checksum: 31b6b311b6731f1658277a9dfff6632c
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-30T11:28:13Z
  date_updated: 2023-01-30T11:28:13Z
  file_id: '12460'
  file_name: 2022_PlosCompBio_Schmid.pdf
  file_size: 3143222
  relation: main_file
  success: 1
file_date_updated: 2023-01-30T11:28:13Z
fulldoi: https://doi.org/10.1371/journal.pcbi.1010149
has_accepted_license: '1'
intvolume: '        18'
isi: 1
issue: '6'
keyword:
- Computational Theory and Mathematics
- Cellular and Molecular Neuroscience
- Genetics
- Molecular Biology
- Ecology
- Modeling and Simulation
- Ecology
- Evolution
- Behavior and Systematics
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
  call_identifier: H2020
  grant_number: '863818'
  name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
publication: PLOS Computational Biology
publication_identifier:
  eissn:
  - 1553-7358
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Direct reciprocity between individuals that use different strategy spaces
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 18
year: '2022'
...
---
_id: '12281'
abstract:
- lang: eng
  text: We study the hydrodynamic and hydrostatic limits of the one-dimensional open
    symmetric inclusion process with slow boundary. Depending on the value of the
    parameter tuning the interaction rate of the bulk of the system with the boundary,
    we obtain a linear heat equation with either Dirichlet, Robin or Neumann boundary
    conditions as hydrodynamic equation. In our approach, we combine duality and first-second
    class particle techniques to reduce the scaling limit of the inclusion process
    to the limiting behavior of a single, non-interacting, particle.
acknowledgement: "C.F. and P.G. thank FCT/Portugal for support through the project
  UID/MAT/04459/2013.\r\nThis project has received funding from the European Research
  Council (ERC) under the European Union’s Horizon 2020 research and innovative programme
  (grant agreement No. 715734). F.S. was founded by the European Union’s Horizon 2020
  research and innovation programme under the Marie-Skłodowska-Curie grant agreement
  No. 754411.\r\nF.S. wishes to thank Joe P. Chen for some fruitful discussions at
  an early stage of this work. F.S. thanks CAMGSD, IST, Lisbon, where part of this
  work has been done, and the European research and innovative programme No. 715734
  for the kind hospitality."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Chiara
  full_name: Franceschini, Chiara
  last_name: Franceschini
- first_name: Patrícia
  full_name: Gonçalves, Patrícia
  last_name: Gonçalves
- first_name: Federico
  full_name: Sau, Federico
  id: E1836206-9F16-11E9-8814-AEFDE5697425
  last_name: Sau
citation:
  ama: 'Franceschini C, Gonçalves P, Sau F. Symmetric inclusion process with slow
    boundary: Hydrodynamics and hydrostatics. <i>Bernoulli</i>. 2022;28(2):1340-1381.
    doi:<a href="https://doi.org/10.3150/21-bej1390">10.3150/21-bej1390</a>'
  apa: 'Franceschini, C., Gonçalves, P., &#38; Sau, F. (2022). Symmetric inclusion
    process with slow boundary: Hydrodynamics and hydrostatics. <i>Bernoulli</i>.
    Bernoulli Society for Mathematical Statistics and Probability. <a href="https://doi.org/10.3150/21-bej1390">https://doi.org/10.3150/21-bej1390</a>'
  chicago: 'Franceschini, Chiara, Patrícia Gonçalves, and Federico Sau. “Symmetric
    Inclusion Process with Slow Boundary: Hydrodynamics and Hydrostatics.” <i>Bernoulli</i>.
    Bernoulli Society for Mathematical Statistics and Probability, 2022. <a href="https://doi.org/10.3150/21-bej1390">https://doi.org/10.3150/21-bej1390</a>.'
  ieee: 'C. Franceschini, P. Gonçalves, and F. Sau, “Symmetric inclusion process with
    slow boundary: Hydrodynamics and hydrostatics,” <i>Bernoulli</i>, vol. 28, no.
    2. Bernoulli Society for Mathematical Statistics and Probability, pp. 1340–1381,
    2022.'
  ista: 'Franceschini C, Gonçalves P, Sau F. 2022. Symmetric inclusion process with
    slow boundary: Hydrodynamics and hydrostatics. Bernoulli. 28(2), 1340–1381.'
  mla: 'Franceschini, Chiara, et al. “Symmetric Inclusion Process with Slow Boundary:
    Hydrodynamics and Hydrostatics.” <i>Bernoulli</i>, vol. 28, no. 2, Bernoulli Society
    for Mathematical Statistics and Probability, 2022, pp. 1340–81, doi:<a href="https://doi.org/10.3150/21-bej1390">10.3150/21-bej1390</a>.'
  short: C. Franceschini, P. Gonçalves, F. Sau, Bernoulli 28 (2022) 1340–1381.
date_created: 2023-01-16T10:03:04Z
date_published: 2022-05-01T00:00:00Z
date_updated: 2025-04-14T07:44:00Z
day: '01'
department:
- _id: JaMa
doi: 10.3150/21-bej1390
ec_funded: 1
external_id:
  arxiv:
  - '2007.11998'
  isi:
  - '000766619100025'
fulldoi: https://doi.org/10.3150/21-bej1390
intvolume: '        28'
isi: 1
issue: '2'
keyword:
- Statistics and Probability
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2007.11998
month: '05'
oa: 1
oa_version: Preprint
page: 1340-1381
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: Bernoulli
publication_identifier:
  issn:
  - 1350-7265
publication_status: published
publisher: Bernoulli Society for Mathematical Statistics and Probability
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Symmetric inclusion process with slow boundary: Hydrodynamics and hydrostatics'
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 28
year: '2022'
...
---
_id: '12282'
abstract:
- lang: eng
  text: From a simple thought to a multicellular movement
acknowledgement: The authors want to thank Professors Carrie Bernecky, Tom Henzinger,
  Martin Loose and Gaia Novarino for accepting to be interviewed, thus giving significant
  contribution to the discussion that lead to this article.
article_number: '260017'
article_processing_charge: No
article_type: letter_note
author:
- first_name: Nicole
  full_name: Amberg, Nicole
  id: 4CD6AAC6-F248-11E8-B48F-1D18A9856A87
  last_name: Amberg
  orcid: 0000-0002-3183-8207
- first_name: Melissa A
  full_name: Stouffer, Melissa A
  id: 4C9372C4-F248-11E8-B48F-1D18A9856A87
  last_name: Stouffer
- first_name: Irene
  full_name: Vercellino, Irene
  id: 3ED6AF16-F248-11E8-B48F-1D18A9856A87
  last_name: Vercellino
  orcid: 0000-0001-5618-3449
citation:
  ama: Amberg N, Stouffer MA, Vercellino I. Operation STEM fatale – how an equity,
    diversity and inclusion initiative has brought us to reflect on the current challenges
    in cell biology and science as a whole. <i>Journal of Cell Science</i>. 2022;135(8).
    doi:<a href="https://doi.org/10.1242/jcs.260017">10.1242/jcs.260017</a>
  apa: Amberg, N., Stouffer, M. A., &#38; Vercellino, I. (2022). Operation STEM fatale
    – how an equity, diversity and inclusion initiative has brought us to reflect
    on the current challenges in cell biology and science as a whole. <i>Journal of
    Cell Science</i>. The Company of Biologists. <a href="https://doi.org/10.1242/jcs.260017">https://doi.org/10.1242/jcs.260017</a>
  chicago: Amberg, Nicole, Melissa A Stouffer, and Irene Vercellino. “Operation STEM
    Fatale – How an Equity, Diversity and Inclusion Initiative Has Brought Us to Reflect
    on the Current Challenges in Cell Biology and Science as a Whole.” <i>Journal
    of Cell Science</i>. The Company of Biologists, 2022. <a href="https://doi.org/10.1242/jcs.260017">https://doi.org/10.1242/jcs.260017</a>.
  ieee: N. Amberg, M. A. Stouffer, and I. Vercellino, “Operation STEM fatale – how
    an equity, diversity and inclusion initiative has brought us to reflect on the
    current challenges in cell biology and science as a whole,” <i>Journal of Cell
    Science</i>, vol. 135, no. 8. The Company of Biologists, 2022.
  ista: Amberg N, Stouffer MA, Vercellino I. 2022. Operation STEM fatale – how an
    equity, diversity and inclusion initiative has brought us to reflect on the current
    challenges in cell biology and science as a whole. Journal of Cell Science. 135(8),
    260017.
  mla: Amberg, Nicole, et al. “Operation STEM Fatale – How an Equity, Diversity and
    Inclusion Initiative Has Brought Us to Reflect on the Current Challenges in Cell
    Biology and Science as a Whole.” <i>Journal of Cell Science</i>, vol. 135, no.
    8, 260017, The Company of Biologists, 2022, doi:<a href="https://doi.org/10.1242/jcs.260017">10.1242/jcs.260017</a>.
  short: N. Amberg, M.A. Stouffer, I. Vercellino, Journal of Cell Science 135 (2022).
corr_author: '1'
date_created: 2023-01-16T10:03:14Z
date_published: 2022-04-19T00:00:00Z
date_updated: 2024-10-09T21:03:55Z
day: '19'
department:
- _id: SiHi
- _id: LeSa
doi: 10.1242/jcs.260017
external_id:
  isi:
  - '000798123600015'
  pmid:
  - '35438168'
fulldoi: https://doi.org/10.1242/jcs.260017
intvolume: '       135'
isi: 1
issue: '8'
language:
- iso: eng
month: '04'
oa_version: None
pmid: 1
publication: Journal of Cell Science
publication_identifier:
  eissn:
  - 1477-9137
  issn:
  - 0021-9533
publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
scopus_import: '1'
status: public
title: Operation STEM fatale – how an equity, diversity and inclusion initiative has
  brought us to reflect on the current challenges in cell biology and science as a
  whole
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 135
year: '2022'
...
---
_id: '12283'
abstract:
- lang: eng
  text: Neurons extend axons to form the complex circuitry of the mature brain. This
    depends on the coordinated response and continuous remodelling of the microtubule
    and F-actin networks in the axonal growth cone. Growth cone architecture remains
    poorly understood at nanoscales. We therefore investigated mouse hippocampal neuron
    growth cones using cryo-electron tomography to directly visualise their three-dimensional
    subcellular architecture with molecular detail. Our data showed that the hexagonal
    arrays of actin bundles that form filopodia penetrate and terminate deep within
    the growth cone interior. We directly observed the modulation of these and other
    growth cone actin bundles by alteration of individual F-actin helical structures.
    Microtubules with blunt, slightly flared or gently curved ends predominated in
    the growth cone, frequently contained lumenal particles and exhibited lattice
    defects. Investigation of the effect of absence of doublecortin, a neurodevelopmental
    cytoskeleton regulator, on growth cone cytoskeleton showed no major anomalies
    in overall growth cone organisation or in F-actin subpopulations. However, our
    data suggested that microtubules sustained more structural defects, highlighting
    the importance of microtubule integrity during growth cone migration.
acknowledgement: "J.A. was supported by a grant from the Medical Research Council
  (MRC), UK (MR/R000352/1) to C.A.M. Cryo-EM data were collected on equipment funded
  by the Wellcome Trust, UK (079605/Z/06/Z) and the Biotechnology and Biological Sciences
  Research Council (BBSRC) UK (BB/L014211/1). F.F.’s salary and institute were supported
  by Inserm (Institut National de la Santé et de la Recherche Médicale), CNRS (Centre
  National de la Recherche Scientifique) and Sorbonne Université. F.F.’s group was
  particularly supported by Agence Nationale de la\r\nRecherche (ANR-16-CE16-0011-03)
  and Seventh Framework Programme (EUHEALTH-\r\n2013, DESIRE, N° 60253; also funding
  M.S.’s salary) and the European Cooperation in Science and Technology (COST Action
  CA16118). Open Access funding provided by Birkbeck College: Birkbeck University
  of London. Deposited in PMC for immediate release."
article_number: '259234'
article_processing_charge: No
article_type: original
author:
- first_name: Joseph
  full_name: Atherton, Joseph
  last_name: Atherton
- first_name: Melissa A
  full_name: Stouffer, Melissa A
  id: 4C9372C4-F248-11E8-B48F-1D18A9856A87
  last_name: Stouffer
- first_name: Fiona
  full_name: Francis, Fiona
  last_name: Francis
- first_name: Carolyn A.
  full_name: Moores, Carolyn A.
  last_name: Moores
citation:
  ama: Atherton J, Stouffer MA, Francis F, Moores CA. Visualising the cytoskeletal
    machinery in neuronal growth cones using cryo-electron tomography. <i>Journal
    of Cell Science</i>. 2022;135(7). doi:<a href="https://doi.org/10.1242/jcs.259234">10.1242/jcs.259234</a>
  apa: Atherton, J., Stouffer, M. A., Francis, F., &#38; Moores, C. A. (2022). Visualising
    the cytoskeletal machinery in neuronal growth cones using cryo-electron tomography.
    <i>Journal of Cell Science</i>. The Company of Biologists. <a href="https://doi.org/10.1242/jcs.259234">https://doi.org/10.1242/jcs.259234</a>
  chicago: Atherton, Joseph, Melissa A Stouffer, Fiona Francis, and Carolyn A. Moores.
    “Visualising the Cytoskeletal Machinery in Neuronal Growth Cones Using Cryo-Electron
    Tomography.” <i>Journal of Cell Science</i>. The Company of Biologists, 2022.
    <a href="https://doi.org/10.1242/jcs.259234">https://doi.org/10.1242/jcs.259234</a>.
  ieee: J. Atherton, M. A. Stouffer, F. Francis, and C. A. Moores, “Visualising the
    cytoskeletal machinery in neuronal growth cones using cryo-electron tomography,”
    <i>Journal of Cell Science</i>, vol. 135, no. 7. The Company of Biologists, 2022.
  ista: Atherton J, Stouffer MA, Francis F, Moores CA. 2022. Visualising the cytoskeletal
    machinery in neuronal growth cones using cryo-electron tomography. Journal of
    Cell Science. 135(7), 259234.
  mla: Atherton, Joseph, et al. “Visualising the Cytoskeletal Machinery in Neuronal
    Growth Cones Using Cryo-Electron Tomography.” <i>Journal of Cell Science</i>,
    vol. 135, no. 7, 259234, The Company of Biologists, 2022, doi:<a href="https://doi.org/10.1242/jcs.259234">10.1242/jcs.259234</a>.
  short: J. Atherton, M.A. Stouffer, F. Francis, C.A. Moores, Journal of Cell Science
    135 (2022).
date_created: 2023-01-16T10:03:24Z
date_published: 2022-04-01T00:00:00Z
date_updated: 2023-08-04T10:28:34Z
day: '01'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1242/jcs.259234
external_id:
  isi:
  - '000783840400010'
  pmid:
  - '35383828'
file:
- access_level: open_access
  checksum: 4346ed32cb7c89a8ca051c7da68a9a1c
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-30T11:41:01Z
  date_updated: 2023-01-30T11:41:01Z
  file_id: '12461'
  file_name: 2022_JourCellBiology_Atherton.pdf
  file_size: 13868733
  relation: main_file
  success: 1
file_date_updated: 2023-01-30T11:41:01Z
fulldoi: https://doi.org/10.1242/jcs.259234
has_accepted_license: '1'
intvolume: '       135'
isi: 1
issue: '7'
keyword:
- Cell Biology
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
publication: Journal of Cell Science
publication_identifier:
  eissn:
  - 1477-9137
  issn:
  - 0021-9533
publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
scopus_import: '1'
status: public
title: Visualising the cytoskeletal machinery in neuronal growth cones using cryo-electron
  tomography
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 135
year: '2022'
...
---
_id: '12288'
abstract:
- lang: eng
  text: To understand the function of neuronal circuits, it is crucial to disentangle
    the connectivity patterns within the network. However, most tools currently used
    to explore connectivity have low throughput, low selectivity, or limited accessibility.
    Here, we report the development of an improved packaging system for the production
    of the highly neurotropic RVdGenvA-CVS-N2c rabies viral vectors, yielding titers
    orders of magnitude higher with no background contamination, at a fraction of
    the production time, while preserving the efficiency of transsynaptic labeling.
    Along with the production pipeline, we developed suites of ‘starter’ AAV and bicistronic
    RVdG-CVS-N2c vectors, enabling retrograde labeling from a wide range of neuronal
    populations, tailored for diverse experimental requirements. We demonstrate the
    power and flexibility of the new system by uncovering hidden local and distal
    inhibitory connections in the mouse hippocampal formation and by imaging the functional
    properties of a cortical microcircuit across weeks. Our novel production pipeline
    provides a convenient approach to generate new rabies vectors, while our toolkit
    flexibly and efficiently expands the current capacity to label, manipulate and
    image the neuronal activity of interconnected neuronal circuits in vitro and in
    vivo.
acknowledged_ssus:
- _id: Bio
- _id: PreCl
acknowledgement: We thank F Marr for technical assistance, A Murray for RVdG-CVS-N2c
  viruses and Neuro2A packaging cell-lines and J Watson for reading the manuscript.
  This research was supported by the Scientific Service Units (SSU) of IST-Austria
  through resources provided by the Imaging and Optics Facility (IOF) and the Preclinical
  Facility (PCF). This project was funded by the European Research Council (ERC) under
  the European Union’s Horizon 2020 research and innovation programme (ERC advanced
  grant No 692692, PJ, ERC starting grant No 756502, MJ), the Fond zur Förderung der
  Wissenschaftlichen Forschung (Z 312-B27, Wittgenstein award, PJ), the Human Frontier
  Science Program (LT000256/2018-L, AS) and EMBO (ALTF 1098-2017, AS).
article_number: '79848'
article_processing_charge: No
article_type: original
author:
- first_name: Anton L
  full_name: Sumser, Anton L
  id: 3320A096-F248-11E8-B48F-1D18A9856A87
  last_name: Sumser
  orcid: 0000-0002-4792-1881
- first_name: Maximilian A
  full_name: Jösch, Maximilian A
  id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
  last_name: Jösch
  orcid: 0000-0002-3937-1330
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
- first_name: Yoav
  full_name: Ben Simon, Yoav
  id: 43DF3136-F248-11E8-B48F-1D18A9856A87
  last_name: Ben Simon
citation:
  ama: Sumser AL, Jösch MA, Jonas PM, Ben Simon Y. Fast, high-throughput production
    of improved rabies viral vectors for specific, efficient and versatile transsynaptic
    retrograde labeling. <i>eLife</i>. 2022;11. doi:<a href="https://doi.org/10.7554/elife.79848">10.7554/elife.79848</a>
  apa: Sumser, A. L., Jösch, M. A., Jonas, P. M., &#38; Ben Simon, Y. (2022). Fast,
    high-throughput production of improved rabies viral vectors for specific, efficient
    and versatile transsynaptic retrograde labeling. <i>ELife</i>. eLife Sciences
    Publications. <a href="https://doi.org/10.7554/elife.79848">https://doi.org/10.7554/elife.79848</a>
  chicago: Sumser, Anton L, Maximilian A Jösch, Peter M Jonas, and Yoav Ben Simon.
    “Fast, High-Throughput Production of Improved Rabies Viral Vectors for Specific,
    Efficient and Versatile Transsynaptic Retrograde Labeling.” <i>ELife</i>. eLife
    Sciences Publications, 2022. <a href="https://doi.org/10.7554/elife.79848">https://doi.org/10.7554/elife.79848</a>.
  ieee: A. L. Sumser, M. A. Jösch, P. M. Jonas, and Y. Ben Simon, “Fast, high-throughput
    production of improved rabies viral vectors for specific, efficient and versatile
    transsynaptic retrograde labeling,” <i>eLife</i>, vol. 11. eLife Sciences Publications,
    2022.
  ista: Sumser AL, Jösch MA, Jonas PM, Ben Simon Y. 2022. Fast, high-throughput production
    of improved rabies viral vectors for specific, efficient and versatile transsynaptic
    retrograde labeling. eLife. 11, 79848.
  mla: Sumser, Anton L., et al. “Fast, High-Throughput Production of Improved Rabies
    Viral Vectors for Specific, Efficient and Versatile Transsynaptic Retrograde Labeling.”
    <i>ELife</i>, vol. 11, 79848, eLife Sciences Publications, 2022, doi:<a href="https://doi.org/10.7554/elife.79848">10.7554/elife.79848</a>.
  short: A.L. Sumser, M.A. Jösch, P.M. Jonas, Y. Ben Simon, ELife 11 (2022).
corr_author: '1'
date_created: 2023-01-16T10:04:15Z
date_published: 2022-09-15T00:00:00Z
date_updated: 2025-04-15T08:29:05Z
day: '15'
ddc:
- '570'
department:
- _id: MaJö
- _id: PeJo
doi: 10.7554/elife.79848
ec_funded: 1
external_id:
  isi:
  - '000892204300001'
  pmid:
  - '36040301'
file:
- access_level: open_access
  checksum: 5a2a65e3e7225090c3d8199f3bbd7b7b
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-30T11:50:53Z
  date_updated: 2023-01-30T11:50:53Z
  file_id: '12463'
  file_name: 2022_eLife_Sumser.pdf
  file_size: 8506811
  relation: main_file
  success: 1
file_date_updated: 2023-01-30T11:50:53Z
fulldoi: https://doi.org/10.7554/elife.79848
has_accepted_license: '1'
intvolume: '        11'
isi: 1
keyword:
- General Immunology and Microbiology
- General Biochemistry
- Genetics and Molecular Biology
- General Medicine
- General Neuroscience
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '692692'
  name: Biophysics and circuit function of a giant cortical glutamatergic synapse
- _id: 2634E9D2-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '756502'
  name: Circuits of Visual Attention
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z00312
  name: Synaptic communication in neuronal microcircuits
- _id: 266D407A-B435-11E9-9278-68D0E5697425
  grant_number: LT000256
  name: Neuronal networks of salience and spatial detection in the murine superior
    colliculus
- _id: 264FEA02-B435-11E9-9278-68D0E5697425
  grant_number: ALTF 1098-2017
  name: Connecting sensory with motor processing in the superior colliculus
publication: eLife
publication_identifier:
  eissn:
  - 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fast, high-throughput production of improved rabies viral vectors for specific,
  efficient and versatile transsynaptic retrograde labeling
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11
year: '2022'
...
---
_id: '12290'
abstract:
- lang: eng
  text: We prove local laws, i.e. optimal concentration estimates for arbitrary products
    of resolvents of a Wigner random matrix with deterministic matrices in between.
    We find that the size of such products heavily depends on whether some of the
    deterministic matrices are traceless. Our estimates correctly account for this
    dependence and they hold optimally down to the smallest possible spectral scale.
acknowledgement: L. Erdős was supported by ERC Advanced Grant “RMTBeyond” No. 101020331.
  D. Schröder was supported by Dr. Max Rössler, the Walter Haefner Foundation and
  the ETH Zürich Foundation.
article_processing_charge: No
article_type: original
author:
- first_name: Giorgio
  full_name: Cipolloni, Giorgio
  id: 42198EFA-F248-11E8-B48F-1D18A9856A87
  last_name: Cipolloni
  orcid: 0000-0002-4901-7992
- first_name: László
  full_name: Erdös, László
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
- first_name: Dominik J
  full_name: Schröder, Dominik J
  id: 408ED176-F248-11E8-B48F-1D18A9856A87
  last_name: Schröder
  orcid: 0000-0002-2904-1856
citation:
  ama: Cipolloni G, Erdös L, Schröder DJ. Optimal multi-resolvent local laws for Wigner
    matrices. <i>Electronic Journal of Probability</i>. 2022;27:1-38. doi:<a href="https://doi.org/10.1214/22-ejp838">10.1214/22-ejp838</a>
  apa: Cipolloni, G., Erdös, L., &#38; Schröder, D. J. (2022). Optimal multi-resolvent
    local laws for Wigner matrices. <i>Electronic Journal of Probability</i>. Institute
    of Mathematical Statistics. <a href="https://doi.org/10.1214/22-ejp838">https://doi.org/10.1214/22-ejp838</a>
  chicago: Cipolloni, Giorgio, László Erdös, and Dominik J Schröder. “Optimal Multi-Resolvent
    Local Laws for Wigner Matrices.” <i>Electronic Journal of Probability</i>. Institute
    of Mathematical Statistics, 2022. <a href="https://doi.org/10.1214/22-ejp838">https://doi.org/10.1214/22-ejp838</a>.
  ieee: G. Cipolloni, L. Erdös, and D. J. Schröder, “Optimal multi-resolvent local
    laws for Wigner matrices,” <i>Electronic Journal of Probability</i>, vol. 27.
    Institute of Mathematical Statistics, pp. 1–38, 2022.
  ista: Cipolloni G, Erdös L, Schröder DJ. 2022. Optimal multi-resolvent local laws
    for Wigner matrices. Electronic Journal of Probability. 27, 1–38.
  mla: Cipolloni, Giorgio, et al. “Optimal Multi-Resolvent Local Laws for Wigner Matrices.”
    <i>Electronic Journal of Probability</i>, vol. 27, Institute of Mathematical Statistics,
    2022, pp. 1–38, doi:<a href="https://doi.org/10.1214/22-ejp838">10.1214/22-ejp838</a>.
  short: G. Cipolloni, L. Erdös, D.J. Schröder, Electronic Journal of Probability
    27 (2022) 1–38.
corr_author: '1'
date_created: 2023-01-16T10:04:38Z
date_published: 2022-09-12T00:00:00Z
date_updated: 2025-04-14T07:57:19Z
day: '12'
ddc:
- '510'
department:
- _id: LaEr
doi: 10.1214/22-ejp838
ec_funded: 1
external_id:
  isi:
  - '000910863700003'
file:
- access_level: open_access
  checksum: bb647b48fbdb59361210e425c220cdcb
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-30T11:59:21Z
  date_updated: 2023-01-30T11:59:21Z
  file_id: '12464'
  file_name: 2022_ElecJournProbability_Cipolloni.pdf
  file_size: 502149
  relation: main_file
  success: 1
file_date_updated: 2023-01-30T11:59:21Z
fulldoi: https://doi.org/10.1214/22-ejp838
has_accepted_license: '1'
intvolume: '        27'
isi: 1
keyword:
- Statistics
- Probability and Uncertainty
- Statistics and Probability
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 1-38
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
  call_identifier: H2020
  grant_number: '101020331'
  name: Random matrices beyond Wigner-Dyson-Mehta
publication: Electronic Journal of Probability
publication_identifier:
  eissn:
  - 1083-6489
publication_status: published
publisher: Institute of Mathematical Statistics
quality_controlled: '1'
scopus_import: '1'
status: public
title: Optimal multi-resolvent local laws for Wigner matrices
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 27
year: '2022'
...
---
_id: '12294'
abstract:
- lang: eng
  text: Brassicaceae are blessed with specialized metabolites called glucosinolates
    (GSLs), which along with their degradation products, are beneficial in agriculture
    and human health. To date, more than 130 GSL structures have been identified,
    mostly derived from the amino acid methionine. The biosynthesis of methionine-derived
    aliphatic GSLs starts with a side-chain elongation step involving a recursive
    three-step cyclic process that incorporates a new methylene group into the 2-oxo
    acid to form a series of elongated 2-oxo acids. Methylthioalkylmalate synthase
    (MAMS) catalyzes the first committed step in the side-chain elongation of methionine-derived
    GSLs. The substrate specificity of MAMS with different 2-oxo acids determines
    whether reaction products of a given cycle enter for an additional round of chain
    elongation or enter into core GSLs structure formation. Multiple MAMS encoding
    genes are present in the Brassicaceae species and are known to play a central
    role in shaping the diverse profile of aliphatic GSLs. We recently established
    a highly sensitive LC-MS/MS-based methodology that quantifies the MAMS activity
    by estimating the amount of the next intermediate of the pathway, the 2-malate
    derivatives. Overall, this chapter describes the protocol for the expression,
    purification, and steady-state kinetic analysis of the recombinant MAMS protein.
alternative_title:
- Methods in Enzymology
article_processing_charge: No
author:
- first_name: Roshan
  full_name: Kumar, Roshan
  id: 50e95140-3016-11ec-9e1a-881b648a1367
  last_name: Kumar
  orcid: 0000-0002-0346-9125
- first_name: Michael
  full_name: Reichelt, Michael
  last_name: Reichelt
- first_name: Naveen C.
  full_name: Bisht, Naveen C.
  last_name: Bisht
citation:
  ama: 'Kumar R, Reichelt M, Bisht NC. An LC-MS/MS Assay for Enzymatic Characterization
    of Methylthioalkylmalate Synthase (MAMS) Involved in Glucosinolate Biosynthesis.
    In: Jez J, ed. <i>Biochemical Pathways and Environmental Responses in Plants:
    Part A</i>. Vol 676. Elsevier; 2022:49-69. doi:<a href="https://doi.org/10.1016/bs.mie.2022.07.019">10.1016/bs.mie.2022.07.019</a>'
  apa: 'Kumar, R., Reichelt, M., &#38; Bisht, N. C. (2022). An LC-MS/MS Assay for
    Enzymatic Characterization of Methylthioalkylmalate Synthase (MAMS) Involved in
    Glucosinolate Biosynthesis. In J. Jez (Ed.), <i>Biochemical Pathways and Environmental
    Responses in Plants: Part A</i> (Vol. 676, pp. 49–69). Elsevier. <a href="https://doi.org/10.1016/bs.mie.2022.07.019">https://doi.org/10.1016/bs.mie.2022.07.019</a>'
  chicago: 'Kumar, Roshan, Michael Reichelt, and Naveen C. Bisht. “An LC-MS/MS Assay
    for Enzymatic Characterization of Methylthioalkylmalate Synthase (MAMS) Involved
    in Glucosinolate Biosynthesis.” In <i>Biochemical Pathways and Environmental Responses
    in Plants: Part A</i>, edited by Joseph Jez, 676:49–69. Elsevier, 2022. <a href="https://doi.org/10.1016/bs.mie.2022.07.019">https://doi.org/10.1016/bs.mie.2022.07.019</a>.'
  ieee: 'R. Kumar, M. Reichelt, and N. C. Bisht, “An LC-MS/MS Assay for Enzymatic
    Characterization of Methylthioalkylmalate Synthase (MAMS) Involved in Glucosinolate
    Biosynthesis,” in <i>Biochemical Pathways and Environmental Responses in Plants:
    Part A</i>, vol. 676, J. Jez, Ed. Elsevier, 2022, pp. 49–69.'
  ista: 'Kumar R, Reichelt M, Bisht NC. 2022.An LC-MS/MS Assay for Enzymatic Characterization
    of Methylthioalkylmalate Synthase (MAMS) Involved in Glucosinolate Biosynthesis.
    In: Biochemical Pathways and Environmental Responses in Plants: Part A. Methods
    in Enzymology, vol. 676, 49–69.'
  mla: 'Kumar, Roshan, et al. “An LC-MS/MS Assay for Enzymatic Characterization of
    Methylthioalkylmalate Synthase (MAMS) Involved in Glucosinolate Biosynthesis.”
    <i>Biochemical Pathways and Environmental Responses in Plants: Part A</i>, edited
    by Joseph Jez, vol. 676, Elsevier, 2022, pp. 49–69, doi:<a href="https://doi.org/10.1016/bs.mie.2022.07.019">10.1016/bs.mie.2022.07.019</a>.'
  short: 'R. Kumar, M. Reichelt, N.C. Bisht, in:, J. Jez (Ed.), Biochemical Pathways
    and Environmental Responses in Plants: Part A, Elsevier, 2022, pp. 49–69.'
date_created: 2023-01-16T10:05:13Z
date_published: 2022-10-21T00:00:00Z
date_updated: 2025-07-03T14:02:58Z
day: '21'
doi: 10.1016/bs.mie.2022.07.019
editor:
- first_name: Joseph
  full_name: Jez, Joseph
  last_name: Jez
external_id:
  pmid:
  - '36280361'
fulldoi: https://doi.org/10.1016/bs.mie.2022.07.019
intvolume: '       676'
language:
- iso: eng
month: '10'
oa_version: None
page: 49-69
pmid: 1
publication: 'Biochemical Pathways and Environmental Responses in Plants: Part A'
publication_identifier:
  isbn:
  - '9780323955614'
  issn:
  - 0076-6879
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: An LC-MS/MS Assay for Enzymatic Characterization of Methylthioalkylmalate Synthase
  (MAMS) Involved in Glucosinolate Biosynthesis
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 676
year: '2022'
...
---
_id: '12298'
abstract:
- lang: eng
  text: 'Existing committee-based Byzantine state machine replication (SMR) protocols,
    typically deployed in production blockchains, face a clear trade-off: (1) they
    either achieve linear communication cost in the steady state, but sacrifice liveness
    during periods of asynchrony, or (2) they are robust (progress with probability
    one) but pay quadratic communication cost. We believe this trade-off is unwarranted
    since existing linear protocols still have asymptotic quadratic cost in the worst
    case. We design Ditto, a Byzantine SMR protocol that enjoys the best of both worlds:
    optimal communication on and off the steady state (linear and quadratic, respectively)
    and progress guarantee under asynchrony and DDoS attacks. We achieve this by replacing
    the view-synchronization of partially synchronous protocols with an asynchronous
    fallback mechanism at no extra asymptotic cost. Specifically, we start from HotStuff,
    a state-of-the-art linear protocol, and gradually build Ditto. As a separate contribution
    and an intermediate step, we design a 2-chain version of HotStuff, Jolteon, which
    leverages a quadratic view-change mechanism to reduce the latency of the standard
    3-chain HotStuff. We implement and experimentally evaluate all our systems to
    prove that breaking the robustness-efficiency trade-off is in the realm of practicality.'
acknowledgement: We thank our shepherd Aniket Kate and the anonymous reviewers at
  FC 2022 for their helpful feedback. This work is supported by the Novi team at Facebook.
  We also thank the Novi Research and Engineering teams for valuable feedback, and
  in particular Mathieu Baudet, Andrey Chursin, George Danezis, Zekun Li, and Dahlia
  Malkhi for discussions that shaped this work.
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Rati
  full_name: Gelashvili, Rati
  last_name: Gelashvili
- first_name: Eleftherios
  full_name: Kokoris Kogias, Eleftherios
  id: f5983044-d7ef-11ea-ac6d-fd1430a26d30
  last_name: Kokoris Kogias
- first_name: Alberto
  full_name: Sonnino, Alberto
  last_name: Sonnino
- first_name: Alexander
  full_name: Spiegelman, Alexander
  last_name: Spiegelman
- first_name: Zhuolun
  full_name: Xiang, Zhuolun
  last_name: Xiang
citation:
  ama: 'Gelashvili R, Kokoris Kogias E, Sonnino A, Spiegelman A, Xiang Z. Jolteon
    and ditto: Network-adaptive efficient consensus with asynchronous fallback. In:
    <i>Financial Cryptography and Data Security</i>. Vol 13411. Springer Nature; 2022:296-315.
    doi:<a href="https://doi.org/10.1007/978-3-031-18283-9_14">10.1007/978-3-031-18283-9_14</a>'
  apa: 'Gelashvili, R., Kokoris Kogias, E., Sonnino, A., Spiegelman, A., &#38; Xiang,
    Z. (2022). Jolteon and ditto: Network-adaptive efficient consensus with asynchronous
    fallback. In <i>Financial Cryptography and Data Security</i> (Vol. 13411, pp.
    296–315). Radisson Grenada Beach Resort, Grenada: Springer Nature. <a href="https://doi.org/10.1007/978-3-031-18283-9_14">https://doi.org/10.1007/978-3-031-18283-9_14</a>'
  chicago: 'Gelashvili, Rati, Eleftherios Kokoris Kogias, Alberto Sonnino, Alexander
    Spiegelman, and Zhuolun Xiang. “Jolteon and Ditto: Network-Adaptive Efficient
    Consensus with Asynchronous Fallback.” In <i>Financial Cryptography and Data Security</i>,
    13411:296–315. Springer Nature, 2022. <a href="https://doi.org/10.1007/978-3-031-18283-9_14">https://doi.org/10.1007/978-3-031-18283-9_14</a>.'
  ieee: 'R. Gelashvili, E. Kokoris Kogias, A. Sonnino, A. Spiegelman, and Z. Xiang,
    “Jolteon and ditto: Network-adaptive efficient consensus with asynchronous fallback,”
    in <i>Financial Cryptography and Data Security</i>, Radisson Grenada Beach Resort,
    Grenada, 2022, vol. 13411, pp. 296–315.'
  ista: 'Gelashvili R, Kokoris Kogias E, Sonnino A, Spiegelman A, Xiang Z. 2022. Jolteon
    and ditto: Network-adaptive efficient consensus with asynchronous fallback. Financial
    Cryptography and Data Security. FC: Financial Cryptography, LNCS, vol. 13411,
    296–315.'
  mla: 'Gelashvili, Rati, et al. “Jolteon and Ditto: Network-Adaptive Efficient Consensus
    with Asynchronous Fallback.” <i>Financial Cryptography and Data Security</i>,
    vol. 13411, Springer Nature, 2022, pp. 296–315, doi:<a href="https://doi.org/10.1007/978-3-031-18283-9_14">10.1007/978-3-031-18283-9_14</a>.'
  short: R. Gelashvili, E. Kokoris Kogias, A. Sonnino, A. Spiegelman, Z. Xiang, in:,
    Financial Cryptography and Data Security, Springer Nature, 2022, pp. 296–315.
conference:
  end_date: 2022-05-06
  location: Radisson Grenada Beach Resort, Grenada
  name: 'FC: Financial Cryptography'
  start_date: 2022-05-02
date_created: 2023-01-16T10:05:51Z
date_published: 2022-10-22T00:00:00Z
date_updated: 2025-09-10T09:52:23Z
day: '22'
department:
- _id: ElKo
doi: 10.1007/978-3-031-18283-9_14
external_id:
  arxiv:
  - '2106.10362'
  isi:
  - '001423640200014'
fulldoi: https://doi.org/10.1007/978-3-031-18283-9_14
intvolume: '     13411'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: ' https://doi.org/10.48550/arXiv.2106.10362'
month: '10'
oa: 1
oa_version: Preprint
page: 296-315
publication: Financial Cryptography and Data Security
publication_identifier:
  eisbn:
  - '9783031182839'
  eissn:
  - 1611-3349
  isbn:
  - '9783031182822'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Jolteon and ditto: Network-adaptive efficient consensus with asynchronous
  fallback'
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 13411
year: '2022'
...
---
_id: '12302'
abstract:
- lang: eng
  text: 'We propose a novel algorithm to decide the language inclusion between (nondeterministic)
    Büchi automata, a PSPACE-complete problem. Our approach, like others before, leverage
    a notion of quasiorder to prune the search for a counterexample by discarding
    candidates which are subsumed by others for the quasiorder. Discarded candidates
    are guaranteed to not compromise the completeness of the algorithm. The novelty
    of our work lies in the quasiorder used to discard candidates. We introduce FORQs
    (family of right quasiorders) that we obtain by adapting the notion of family
    of right congruences put forward by Maler and Staiger in 1993. We define a FORQ-based
    inclusion algorithm which we prove correct and instantiate it for a specific FORQ,
    called the structural FORQ, induced by the Büchi automaton to the right of the
    inclusion sign. The resulting implementation, called FORKLIFT, scales up better
    than the state-of-the-art on a variety of benchmarks including benchmarks from
    program verification and theorem proving for word combinatorics. Artifact: https://doi.org/10.5281/zenodo.6552870'
acknowledgement: This work was partially funded by the ESF Investing in your future,
  the Madrid regional project S2018/TCS-4339 BLOQUES, the Spanish project PGC2018-102210-B-I00
  BOSCO, the Ramón y Cajal fellowship RYC-2016-20281, and the ERC grant PR1001ERC02.
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Kyveli
  full_name: Doveri, Kyveli
  last_name: Doveri
- first_name: Pierre
  full_name: Ganty, Pierre
  last_name: Ganty
- first_name: Nicolas Adrien
  full_name: Mazzocchi, Nicolas Adrien
  id: b26baa86-3308-11ec-87b0-8990f34baa85
  last_name: Mazzocchi
citation:
  ama: 'Doveri K, Ganty P, Mazzocchi NA. FORQ-based language inclusion formal testing.
    In: <i>Computer Aided Verification</i>. Vol 13372. Springer Nature; 2022:109-129.
    doi:<a href="https://doi.org/10.1007/978-3-031-13188-2_6">10.1007/978-3-031-13188-2_6</a>'
  apa: 'Doveri, K., Ganty, P., &#38; Mazzocchi, N. A. (2022). FORQ-based language
    inclusion formal testing. In <i>Computer Aided Verification</i> (Vol. 13372, pp.
    109–129). Haifa, Israel: Springer Nature. <a href="https://doi.org/10.1007/978-3-031-13188-2_6">https://doi.org/10.1007/978-3-031-13188-2_6</a>'
  chicago: Doveri, Kyveli, Pierre Ganty, and Nicolas Adrien Mazzocchi. “FORQ-Based
    Language Inclusion Formal Testing.” In <i>Computer Aided Verification</i>, 13372:109–29.
    Springer Nature, 2022. <a href="https://doi.org/10.1007/978-3-031-13188-2_6">https://doi.org/10.1007/978-3-031-13188-2_6</a>.
  ieee: K. Doveri, P. Ganty, and N. A. Mazzocchi, “FORQ-based language inclusion formal
    testing,” in <i>Computer Aided Verification</i>, Haifa, Israel, 2022, vol. 13372,
    pp. 109–129.
  ista: 'Doveri K, Ganty P, Mazzocchi NA. 2022. FORQ-based language inclusion formal
    testing. Computer Aided Verification. CAV: Computer Aided Verification, LNCS,
    vol. 13372, 109–129.'
  mla: Doveri, Kyveli, et al. “FORQ-Based Language Inclusion Formal Testing.” <i>Computer
    Aided Verification</i>, vol. 13372, Springer Nature, 2022, pp. 109–29, doi:<a
    href="https://doi.org/10.1007/978-3-031-13188-2_6">10.1007/978-3-031-13188-2_6</a>.
  short: K. Doveri, P. Ganty, N.A. Mazzocchi, in:, Computer Aided Verification, Springer
    Nature, 2022, pp. 109–129.
conference:
  end_date: 2022-08-10
  location: Haifa, Israel
  name: 'CAV: Computer Aided Verification'
  start_date: 2022-08-07
date_created: 2023-01-16T10:06:31Z
date_published: 2022-08-06T00:00:00Z
date_updated: 2025-04-14T07:55:56Z
day: '06'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1007/978-3-031-13188-2_6
ec_funded: 1
external_id:
  arxiv:
  - '2207.13549'
  isi:
  - '000870310500006'
file:
- access_level: open_access
  checksum: edc363b1be5447a09063e115c247918a
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-30T12:51:02Z
  date_updated: 2023-01-30T12:51:02Z
  file_id: '12465'
  file_name: 2022_LNCS_Doveri.pdf
  file_size: 497682
  relation: main_file
  success: 1
file_date_updated: 2023-01-30T12:51:02Z
fulldoi: https://doi.org/10.1007/978-3-031-13188-2_6
has_accepted_license: '1'
intvolume: '     13372'
isi: 1
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 109-129
project:
- _id: 62781420-2b32-11ec-9570-8d9b63373d4d
  call_identifier: H2020
  grant_number: '101020093'
  name: Vigilant Algorithmic Monitoring of Software
publication: Computer Aided Verification
publication_identifier:
  eisbn:
  - '9783031131882'
  eissn:
  - 1611-3349
  isbn:
  - '9783031131875'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: FORQ-based language inclusion formal testing
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 13372
year: '2022'
...
---
_id: '12303'
abstract:
- lang: eng
  text: We construct for each choice of a quiver Q, a cohomology theory A, and a poset
    P a “loop Grassmannian” GP(Q,A). This generalizes loop Grassmannians of semisimple
    groups and the loop Grassmannians of based quadratic forms. The addition of a
    “dilation” torus D⊆G2m gives a quantization GPD(Q,A). This construction is motivated
    by the program of introducing an inner cohomology theory in algebraic geometry
    adequate for the Geometric Langlands program (Mirković, Some extensions of the
    notion of loop Grassmannians. Rad Hrvat. Akad. Znan. Umjet. Mat. Znan., the Mardešić
    issue. No. 532, 53–74, 2017) and on the construction of affine quantum groups
    from generalized cohomology theories (Yang and Zhao, Quiver varieties and elliptic
    quantum groups, preprint. arxiv1708.01418).
acknowledgement: I.M. thanks Zhijie Dong for long-term discussions on the material
  that entered this work. We thank Misha Finkelberg for pointing out errors in earlier
  versions. His advice and his insistence have led to a much better paper. A part
  of the writing was done at the conference at IST (Vienna) attended by all coauthors.
  We therefore thank the organizers of the conference and the support of ERC Advanced
  Grant Arithmetic and Physics of Higgs moduli spaces No. 320593. The work of I.M.
  was partially supported by NSF grants. The work of Y.Y. was partially supported
  by the Australian Research Council (ARC) via the award DE190101231. The work of
  G.Z. was partially supported by ARC via the award DE190101222.
alternative_title:
- Trends in Mathematics
article_processing_charge: No
arxiv: 1
author:
- first_name: Ivan
  full_name: Mirković, Ivan
  last_name: Mirković
- first_name: Yaping
  full_name: Yang, Yaping
  last_name: Yang
- first_name: Gufang
  full_name: Zhao, Gufang
  id: 2BC2AC5E-F248-11E8-B48F-1D18A9856A87
  last_name: Zhao
citation:
  ama: 'Mirković I, Yang Y, Zhao G. Loop Grassmannians of Quivers and Affine Quantum
    Groups. In: Baranovskky V, Guay N, Schedler T, eds. <i>Representation Theory and
    Algebraic Geometry</i>. 1st ed. TM. Cham: Springer Nature; Birkhäuser; 2022:347-392.
    doi:<a href="https://doi.org/10.1007/978-3-030-82007-7_8">10.1007/978-3-030-82007-7_8</a>'
  apa: 'Mirković, I., Yang, Y., &#38; Zhao, G. (2022). Loop Grassmannians of Quivers
    and Affine Quantum Groups. In V. Baranovskky, N. Guay, &#38; T. Schedler (Eds.),
    <i>Representation Theory and Algebraic Geometry</i> (1st ed., pp. 347–392). Cham:
    Springer Nature; Birkhäuser. <a href="https://doi.org/10.1007/978-3-030-82007-7_8">https://doi.org/10.1007/978-3-030-82007-7_8</a>'
  chicago: 'Mirković, Ivan, Yaping Yang, and Gufang Zhao. “Loop Grassmannians of Quivers
    and Affine Quantum Groups.” In <i>Representation Theory and Algebraic Geometry</i>,
    edited by Vladimir Baranovskky, Nicolas Guay, and Travis Schedler, 1st ed., 347–92.
    TM. Cham: Springer Nature; Birkhäuser, 2022. <a href="https://doi.org/10.1007/978-3-030-82007-7_8">https://doi.org/10.1007/978-3-030-82007-7_8</a>.'
  ieee: 'I. Mirković, Y. Yang, and G. Zhao, “Loop Grassmannians of Quivers and Affine
    Quantum Groups,” in <i>Representation Theory and Algebraic Geometry</i>, 1st ed.,
    V. Baranovskky, N. Guay, and T. Schedler, Eds. Cham: Springer Nature; Birkhäuser,
    2022, pp. 347–392.'
  ista: 'Mirković I, Yang Y, Zhao G. 2022.Loop Grassmannians of Quivers and Affine
    Quantum Groups. In: Representation Theory and Algebraic Geometry. Trends in Mathematics,
    , 347–392.'
  mla: Mirković, Ivan, et al. “Loop Grassmannians of Quivers and Affine Quantum Groups.”
    <i>Representation Theory and Algebraic Geometry</i>, edited by Vladimir Baranovskky
    et al., 1st ed., Springer Nature; Birkhäuser, 2022, pp. 347–92, doi:<a href="https://doi.org/10.1007/978-3-030-82007-7_8">10.1007/978-3-030-82007-7_8</a>.
  short: I. Mirković, Y. Yang, G. Zhao, in:, V. Baranovskky, N. Guay, T. Schedler
    (Eds.), Representation Theory and Algebraic Geometry, 1st ed., Springer Nature;
    Birkhäuser, Cham, 2022, pp. 347–392.
date_created: 2023-01-16T10:06:41Z
date_published: 2022-06-16T00:00:00Z
date_updated: 2025-04-14T09:12:46Z
day: '16'
department:
- _id: TaHa
doi: 10.1007/978-3-030-82007-7_8
ec_funded: 1
edition: '1'
editor:
- first_name: Vladimir
  full_name: Baranovskky, Vladimir
  last_name: Baranovskky
- first_name: Nicolas
  full_name: Guay, Nicolas
  last_name: Guay
- first_name: Travis
  full_name: Schedler, Travis
  last_name: Schedler
external_id:
  arxiv:
  - '1810.10095'
fulldoi: https://doi.org/10.1007/978-3-030-82007-7_8
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.1810.10095
month: '06'
oa: 1
oa_version: Preprint
page: 347-392
place: Cham
project:
- _id: 25E549F4-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '320593'
  name: Arithmetic and physics of Higgs moduli spaces
publication: Representation Theory and Algebraic Geometry
publication_identifier:
  eisbn:
  - '9783030820077'
  eissn:
  - 2297-024X
  isbn:
  - '9783030820060'
  issn:
  - 2297-0215
publication_status: published
publisher: Springer Nature; Birkhäuser
quality_controlled: '1'
scopus_import: '1'
series_title: TM
status: public
title: Loop Grassmannians of Quivers and Affine Quantum Groups
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '12304'
abstract:
- lang: eng
  text: 'We establish sharp criteria for the instantaneous propagation of free boundaries
    in solutions to the thin-film equation. The criteria are formulated in terms of
    the initial distribution of mass (as opposed to previous almost-optimal results),
    reflecting the fact that mass is a locally conserved quantity for the thin-film
    equation. In the regime of weak slippage, our criteria are at the same time necessary
    and sufficient. The proof of our upper bounds on free boundary propagation is
    based on a strategy of “propagation of degeneracy” down to arbitrarily small spatial
    scales: We combine estimates on the local mass and estimates on energies to show
    that “degeneracy” on a certain space-time cylinder entails “degeneracy” on a spatially
    smaller space-time cylinder with the same time horizon. The derivation of our
    lower bounds on free boundary propagation is based on a combination of a monotone
    quantity and almost optimal estimates established previously by the second author
    with a new estimate connecting motion of mass to entropy production.'
acknowledgement: N. De Nitti acknowledges the kind hospitality of IST Austria within
  the framework of the ISTernship Summer Program 2018, during which most of the present
  article was written. N. DeNitti has received funding by The Austrian Agency for
  International Cooperation in Education &Research (OeAD-GmbH) via its financial support
  of the ISTernship Summer Program 2018. N.De Nitti would also like to thank Giuseppe
  Coclite, Giuseppe Devillanova, Giuseppe Florio, Sebastian Hensel, and Francesco
  Maddalena for several helpful conversations on topics related to this work.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Nicola
  full_name: De Nitti, Nicola
  last_name: De Nitti
- first_name: Julian L
  full_name: Fischer, Julian L
  id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
  last_name: Fischer
  orcid: 0000-0002-0479-558X
citation:
  ama: De Nitti N, Fischer JL. Sharp criteria for the waiting time phenomenon in solutions
    to the thin-film equation. <i>Communications in Partial Differential Equations</i>.
    2022;47(7):1394-1434. doi:<a href="https://doi.org/10.1080/03605302.2022.2056702">10.1080/03605302.2022.2056702</a>
  apa: De Nitti, N., &#38; Fischer, J. L. (2022). Sharp criteria for the waiting time
    phenomenon in solutions to the thin-film equation. <i>Communications in Partial
    Differential Equations</i>. Taylor &#38; Francis. <a href="https://doi.org/10.1080/03605302.2022.2056702">https://doi.org/10.1080/03605302.2022.2056702</a>
  chicago: De Nitti, Nicola, and Julian L Fischer. “Sharp Criteria for the Waiting
    Time Phenomenon in Solutions to the Thin-Film Equation.” <i>Communications in
    Partial Differential Equations</i>. Taylor &#38; Francis, 2022. <a href="https://doi.org/10.1080/03605302.2022.2056702">https://doi.org/10.1080/03605302.2022.2056702</a>.
  ieee: N. De Nitti and J. L. Fischer, “Sharp criteria for the waiting time phenomenon
    in solutions to the thin-film equation,” <i>Communications in Partial Differential
    Equations</i>, vol. 47, no. 7. Taylor &#38; Francis, pp. 1394–1434, 2022.
  ista: De Nitti N, Fischer JL. 2022. Sharp criteria for the waiting time phenomenon
    in solutions to the thin-film equation. Communications in Partial Differential
    Equations. 47(7), 1394–1434.
  mla: De Nitti, Nicola, and Julian L. Fischer. “Sharp Criteria for the Waiting Time
    Phenomenon in Solutions to the Thin-Film Equation.” <i>Communications in Partial
    Differential Equations</i>, vol. 47, no. 7, Taylor &#38; Francis, 2022, pp. 1394–434,
    doi:<a href="https://doi.org/10.1080/03605302.2022.2056702">10.1080/03605302.2022.2056702</a>.
  short: N. De Nitti, J.L. Fischer, Communications in Partial Differential Equations
    47 (2022) 1394–1434.
corr_author: '1'
date_created: 2023-01-16T10:06:50Z
date_published: 2022-07-01T00:00:00Z
date_updated: 2024-10-09T21:03:57Z
day: '01'
department:
- _id: JuFi
doi: 10.1080/03605302.2022.2056702
external_id:
  arxiv:
  - '1907.05342'
  isi:
  - '000805689800001'
fulldoi: https://doi.org/10.1080/03605302.2022.2056702
intvolume: '        47'
isi: 1
issue: '7'
keyword:
- Applied Mathematics
- Analysis
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: ' https://doi.org/10.48550/arXiv.1907.05342'
month: '07'
oa: 1
oa_version: Preprint
page: 1394-1434
publication: Communications in Partial Differential Equations
publication_identifier:
  eissn:
  - 1532-4133
  issn:
  - 0360-5302
publication_status: published
publisher: Taylor & Francis
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sharp criteria for the waiting time phenomenon in solutions to the thin-film
  equation
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 47
year: '2022'
...
---
_id: '12305'
abstract:
- lang: eng
  text: This paper is concerned with the sharp interface limit for the Allen--Cahn
    equation with a nonlinear Robin boundary condition in a bounded smooth domain
    Ω⊂\R2. We assume that a diffuse interface already has developed and that it is
    in contact with the boundary ∂Ω. The boundary condition is designed in such a
    way that the limit problem is given by the mean curvature flow with constant α-contact
    angle. For α close to 90° we prove a local in time convergence result for well-prepared
    initial data for times when a smooth solution to the limit problem exists. Based
    on the latter we construct a suitable curvilinear coordinate system and carry
    out a rigorous asymptotic expansion for the Allen--Cahn equation with the nonlinear
    Robin boundary condition. Moreover, we show a spectral estimate for the corresponding
    linearized Allen--Cahn operator and with its aid we derive strong norm estimates
    for the difference of the exact and approximate solutions using a Gronwall-type
    argument.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Helmut
  full_name: Abels, Helmut
  last_name: Abels
- first_name: Maximilian
  full_name: Moser, Maximilian
  id: a60047a9-da77-11eb-85b4-c4dc385ebb8c
  last_name: Moser
citation:
  ama: Abels H, Moser M. Convergence of the Allen--Cahn equation with a nonlinear
    Robin boundary condition to mean curvature flow with contact angle close to 90°.
    <i>SIAM Journal on Mathematical Analysis</i>. 2022;54(1):114-172. doi:<a href="https://doi.org/10.1137/21m1424925">10.1137/21m1424925</a>
  apa: Abels, H., &#38; Moser, M. (2022). Convergence of the Allen--Cahn equation
    with a nonlinear Robin boundary condition to mean curvature flow with contact
    angle close to 90°. <i>SIAM Journal on Mathematical Analysis</i>. Society for
    Industrial and Applied Mathematics. <a href="https://doi.org/10.1137/21m1424925">https://doi.org/10.1137/21m1424925</a>
  chicago: Abels, Helmut, and Maximilian Moser. “Convergence of the Allen--Cahn Equation
    with a Nonlinear Robin Boundary Condition to Mean Curvature Flow with Contact
    Angle Close to 90°.” <i>SIAM Journal on Mathematical Analysis</i>. Society for
    Industrial and Applied Mathematics, 2022. <a href="https://doi.org/10.1137/21m1424925">https://doi.org/10.1137/21m1424925</a>.
  ieee: H. Abels and M. Moser, “Convergence of the Allen--Cahn equation with a nonlinear
    Robin boundary condition to mean curvature flow with contact angle close to 90°,”
    <i>SIAM Journal on Mathematical Analysis</i>, vol. 54, no. 1. Society for Industrial
    and Applied Mathematics, pp. 114–172, 2022.
  ista: Abels H, Moser M. 2022. Convergence of the Allen--Cahn equation with a nonlinear
    Robin boundary condition to mean curvature flow with contact angle close to 90°.
    SIAM Journal on Mathematical Analysis. 54(1), 114–172.
  mla: Abels, Helmut, and Maximilian Moser. “Convergence of the Allen--Cahn Equation
    with a Nonlinear Robin Boundary Condition to Mean Curvature Flow with Contact
    Angle Close to 90°.” <i>SIAM Journal on Mathematical Analysis</i>, vol. 54, no.
    1, Society for Industrial and Applied Mathematics, 2022, pp. 114–72, doi:<a href="https://doi.org/10.1137/21m1424925">10.1137/21m1424925</a>.
  short: H. Abels, M. Moser, SIAM Journal on Mathematical Analysis 54 (2022) 114–172.
corr_author: '1'
date_created: 2023-01-16T10:07:00Z
date_published: 2022-01-04T00:00:00Z
date_updated: 2024-10-09T21:03:58Z
day: '04'
department:
- _id: JuFi
doi: 10.1137/21m1424925
external_id:
  arxiv:
  - '2105.08434'
  isi:
  - '000762768000004'
fulldoi: https://doi.org/10.1137/21m1424925
intvolume: '        54'
isi: 1
issue: '1'
keyword:
- Applied Mathematics
- Computational Mathematics
- Analysis
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: ' https://doi.org/10.48550/arXiv.2105.08434'
month: '01'
oa: 1
oa_version: Preprint
page: 114-172
publication: SIAM Journal on Mathematical Analysis
publication_identifier:
  eissn:
  - 1095-7154
  issn:
  - 0036-1410
publication_status: published
publisher: Society for Industrial and Applied Mathematics
quality_controlled: '1'
scopus_import: '1'
status: public
title: Convergence of the Allen--Cahn equation with a nonlinear Robin boundary condition
  to mean curvature flow with contact angle close to 90°
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 54
year: '2022'
...
---
_id: '12307'
abstract:
- lang: eng
  text: Point-set topology is among the most abstract branches of mathematics in that
    it lacks tangible notions of distance, length, magnitude, order, and size. There
    is no shape, no geometry, no algebra, and no direction. Everything we are used
    to visualizing is gone. In the teaching and learning of mathematics, this can
    present a conundrum. Yet, this very property makes point set topology perfect
    for teaching and learning abstract mathematical concepts. It clears our minds
    of preconceived intuitions and expectations and forces us to think in new and
    creative ways. In this paper, we present guided investigations into topology through
    questions and thinking strategies that open up fascinating problems. They are
    intended for faculty who already teach or are thinking about teaching a class
    in topology or abstract mathematical reasoning for undergraduates. They can be
    used to build simple to challenging projects in topology, proofs, honors programs,
    and research experiences.
article_processing_charge: No
article_type: original
author:
- first_name: Barbara A.
  full_name: Shipman, Barbara A.
  last_name: Shipman
- first_name: Elizabeth R
  full_name: Stephenson, Elizabeth R
  id: 2D04F932-F248-11E8-B48F-1D18A9856A87
  last_name: Stephenson
  orcid: 0000-0002-6862-208X
citation:
  ama: Shipman BA, Stephenson ER. Tangible topology through the lens of limits. <i>PRIMUS</i>.
    2022;32(5):593-609. doi:<a href="https://doi.org/10.1080/10511970.2021.1872750">10.1080/10511970.2021.1872750</a>
  apa: Shipman, B. A., &#38; Stephenson, E. R. (2022). Tangible topology through the
    lens of limits. <i>PRIMUS</i>. Taylor &#38; Francis. <a href="https://doi.org/10.1080/10511970.2021.1872750">https://doi.org/10.1080/10511970.2021.1872750</a>
  chicago: Shipman, Barbara A., and Elizabeth R Stephenson. “Tangible Topology through
    the Lens of Limits.” <i>PRIMUS</i>. Taylor &#38; Francis, 2022. <a href="https://doi.org/10.1080/10511970.2021.1872750">https://doi.org/10.1080/10511970.2021.1872750</a>.
  ieee: B. A. Shipman and E. R. Stephenson, “Tangible topology through the lens of
    limits,” <i>PRIMUS</i>, vol. 32, no. 5. Taylor &#38; Francis, pp. 593–609, 2022.
  ista: Shipman BA, Stephenson ER. 2022. Tangible topology through the lens of limits.
    PRIMUS. 32(5), 593–609.
  mla: Shipman, Barbara A., and Elizabeth R. Stephenson. “Tangible Topology through
    the Lens of Limits.” <i>PRIMUS</i>, vol. 32, no. 5, Taylor &#38; Francis, 2022,
    pp. 593–609, doi:<a href="https://doi.org/10.1080/10511970.2021.1872750">10.1080/10511970.2021.1872750</a>.
  short: B.A. Shipman, E.R. Stephenson, PRIMUS 32 (2022) 593–609.
corr_author: '1'
date_created: 2023-01-16T10:07:21Z
date_published: 2022-05-28T00:00:00Z
date_updated: 2024-10-09T21:03:58Z
day: '28'
department:
- _id: HeEd
- _id: GradSch
doi: 10.1080/10511970.2021.1872750
fulldoi: https://doi.org/10.1080/10511970.2021.1872750
intvolume: '        32'
issue: '5'
keyword:
- Education
- General Mathematics
language:
- iso: eng
month: '05'
oa_version: None
page: 593-609
publication: PRIMUS
publication_identifier:
  eissn:
  - 1935-4053
  issn:
  - 1051-1970
publication_status: published
publisher: Taylor & Francis
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tangible topology through the lens of limits
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 32
year: '2022'
...
---
_id: '12332'
abstract:
- lang: eng
  text: Activity of sensory neurons is driven not only by external stimuli but also
    by feedback signals from higher brain areas. Attention is one particularly important
    internal signal whose presumed role is to modulate sensory representations such
    that they only encode information currently relevant to the organism at minimal
    cost. This hypothesis has, however, not yet been expressed in a normative computational
    framework. Here, by building on normative principles of probabilistic inference
    and efficient coding, we developed a model of dynamic population coding in the
    visual cortex. By continuously adapting the sensory code to changing demands of
    the perceptual observer, an attention-like modulation emerges. This modulation
    can dramatically reduce the amount of neural activity without deteriorating the
    accuracy of task-specific inferences. Our results suggest that a range of seemingly
    disparate cortical phenomena such as intrinsic gain modulation, attention-related
    tuning modulation, and response variability could be manifestations of the same
    underlying principles, which combine efficient sensory coding with optimal probabilistic
    inference in dynamic environments.
acknowledgement: "We thank Robbe Goris for generously providing figures from his work
  and Ann M. Hermundstad for helpful discussions.\r\nGT & WM were supported by the
  Austrian Science Fund Standalone Grant P 34015 \"Efficient Coding with Biophysical
  Realism\" (https://pf.fwf.ac.at/) WM was additionally supported by the European
  Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie
  Grant Agreement No. 754411 (https://ec.europa.eu/research/mariecurieactions/). The
  funders had no role in study design, data collection and analysis, decision to publish,
  or preparation of the manuscript."
article_processing_charge: No
article_type: original
author:
- first_name: Wiktor F
  full_name: Mlynarski, Wiktor F
  id: 358A453A-F248-11E8-B48F-1D18A9856A87
  last_name: Mlynarski
- first_name: Gašper
  full_name: Tkačik, Gašper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkačik
  orcid: '1'
citation:
  ama: Mlynarski WF, Tkačik G. Efficient coding theory of dynamic attentional modulation.
    <i>PLoS Biology</i>. 2022;20(12):e3001889. doi:<a href="https://doi.org/10.1371/journal.pbio.3001889">10.1371/journal.pbio.3001889</a>
  apa: Mlynarski, W. F., &#38; Tkačik, G. (2022). Efficient coding theory of dynamic
    attentional modulation. <i>PLoS Biology</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pbio.3001889">https://doi.org/10.1371/journal.pbio.3001889</a>
  chicago: Mlynarski, Wiktor F, and Gašper Tkačik. “Efficient Coding Theory of Dynamic
    Attentional Modulation.” <i>PLoS Biology</i>. Public Library of Science, 2022.
    <a href="https://doi.org/10.1371/journal.pbio.3001889">https://doi.org/10.1371/journal.pbio.3001889</a>.
  ieee: W. F. Mlynarski and G. Tkačik, “Efficient coding theory of dynamic attentional
    modulation,” <i>PLoS Biology</i>, vol. 20, no. 12. Public Library of Science,
    p. e3001889, 2022.
  ista: Mlynarski WF, Tkačik G. 2022. Efficient coding theory of dynamic attentional
    modulation. PLoS Biology. 20(12), e3001889.
  mla: Mlynarski, Wiktor F., and Gašper Tkačik. “Efficient Coding Theory of Dynamic
    Attentional Modulation.” <i>PLoS Biology</i>, vol. 20, no. 12, Public Library
    of Science, 2022, p. e3001889, doi:<a href="https://doi.org/10.1371/journal.pbio.3001889">10.1371/journal.pbio.3001889</a>.
  short: W.F. Mlynarski, G. Tkačik, PLoS Biology 20 (2022) e3001889.
corr_author: '1'
date_created: 2023-01-22T23:00:55Z
date_published: 2022-12-21T00:00:00Z
date_updated: 2025-06-11T13:57:01Z
day: '21'
ddc:
- '570'
department:
- _id: GaTk
doi: 10.1371/journal.pbio.3001889
ec_funded: 1
external_id:
  isi:
  - '000925192000001'
  pmid:
  - '36542662'
file:
- access_level: open_access
  checksum: 5d7f1111a87e5f2c1bf92f8886738894
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-23T08:46:40Z
  date_updated: 2023-01-23T08:46:40Z
  file_id: '12337'
  file_name: 2022_PloSBiology_Mlynarski.pdf
  file_size: 4248838
  relation: main_file
  success: 1
file_date_updated: 2023-01-23T08:46:40Z
fulldoi: https://doi.org/10.1371/journal.pbio.3001889
has_accepted_license: '1'
intvolume: '        20'
isi: 1
issue: '12'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: e3001889
pmid: 1
project:
- _id: 626c45b5-2b32-11ec-9570-e509828c1ba6
  grant_number: P34015
  name: Efficient coding with biophysical realism
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: PLoS Biology
publication_identifier:
  eissn:
  - 1545-7885
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Efficient coding theory of dynamic attentional modulation
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '2022'
...
---
_id: '12333'
abstract:
- lang: eng
  text: Together, copy-number and point mutations form the basis for most evolutionary
    novelty, through the process of gene duplication and divergence. While a plethora
    of genomic data reveals the long-term fate of diverging coding sequences and their
    cis-regulatory elements, little is known about the early dynamics around the duplication
    event itself. In microorganisms, selection for increased gene expression often
    drives the expansion of gene copy-number mutations, which serves as a crude adaptation,
    prior to divergence through refining point mutations. Using a simple synthetic
    genetic reporter system that can distinguish between copy-number and point mutations,
    we study their early and transient adaptive dynamics in real time in Escherichia
    coli. We find two qualitatively different routes of adaptation, depending on the
    level of functional improvement needed. In conditions of high gene expression
    demand, the two mutation types occur as a combination. However, under low gene
    expression demand, copy-number and point mutations are mutually exclusive; here,
    owing to their higher frequency, adaptation is dominated by copy-number mutations,
    in a process we term amplification hindrance. Ultimately, due to high reversal
    rates and pleiotropic cost, copy-number mutations may not only serve as a crude
    and transient adaptation, but also constrain sequence divergence over evolutionary
    time scales.
acknowledgement: "We are grateful to N Barton, F Kondrashov, M Lagator, M Pleska,
  R Roemhild, D Siekhaus, and G\r\nTkacik for input on the manuscript and to K Tomasek
  for help with flow cytometry."
article_number: e82240
article_processing_charge: No
article_type: original
author:
- first_name: Isabella
  full_name: Tomanek, Isabella
  id: 3981F020-F248-11E8-B48F-1D18A9856A87
  last_name: Tomanek
  orcid: 0000-0001-6197-363X
- first_name: Calin C
  full_name: Guet, Calin C
  id: 47F8433E-F248-11E8-B48F-1D18A9856A87
  last_name: Guet
  orcid: 0000-0001-6220-2052
citation:
  ama: Tomanek I, Guet CC. Adaptation dynamics between copynumber and point mutations.
    <i>eLife</i>. 2022;11. doi:<a href="https://doi.org/10.7554/ELIFE.82240">10.7554/ELIFE.82240</a>
  apa: Tomanek, I., &#38; Guet, C. C. (2022). Adaptation dynamics between copynumber
    and point mutations. <i>ELife</i>. eLife Sciences Publications. <a href="https://doi.org/10.7554/ELIFE.82240">https://doi.org/10.7554/ELIFE.82240</a>
  chicago: Tomanek, Isabella, and Calin C Guet. “Adaptation Dynamics between Copynumber
    and Point Mutations.” <i>ELife</i>. eLife Sciences Publications, 2022. <a href="https://doi.org/10.7554/ELIFE.82240">https://doi.org/10.7554/ELIFE.82240</a>.
  ieee: I. Tomanek and C. C. Guet, “Adaptation dynamics between copynumber and point
    mutations,” <i>eLife</i>, vol. 11. eLife Sciences Publications, 2022.
  ista: Tomanek I, Guet CC. 2022. Adaptation dynamics between copynumber and point
    mutations. eLife. 11, e82240.
  mla: Tomanek, Isabella, and Calin C. Guet. “Adaptation Dynamics between Copynumber
    and Point Mutations.” <i>ELife</i>, vol. 11, e82240, eLife Sciences Publications,
    2022, doi:<a href="https://doi.org/10.7554/ELIFE.82240">10.7554/ELIFE.82240</a>.
  short: I. Tomanek, C.C. Guet, ELife 11 (2022).
corr_author: '1'
date_created: 2023-01-22T23:00:55Z
date_published: 2022-12-22T00:00:00Z
date_updated: 2025-03-06T14:03:50Z
day: '22'
ddc:
- '570'
department:
- _id: CaGu
doi: 10.7554/ELIFE.82240
external_id:
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language:
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month: '12'
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publication: eLife
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publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
related_material:
  link:
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    url: https://doi.org/10.5281/zenodo.6974122
  record:
  - id: '12339'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Adaptation dynamics between copynumber and point mutations
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2022'
...
---
_id: '12339'
abstract:
- lang: eng
  text: 'Copy-number and point mutations form the basis for most evolutionary novelty
    through the process of gene duplication and divergence. While a plethora of genomic
    sequence data reveals the long-term fate of diverging coding sequences and their
    cis-regulatory elements, little is known about the early dynamics around the duplication
    event itself. In microorganisms, selection for increased gene expression often
    drives the expansion of gene copy-number mutations, which serves as a crude adaptation,
    prior to divergence through refining point mutations. Using a simple synthetic
    genetic system that allows us to distinguish copy-number and point mutations,
    we study their early and transient adaptive dynamics in real-time in Escherichia
    coli. We find two qualitatively different routes of adaptation depending on the
    level of functional improvement selected for: In conditions of high gene expression
    demand, the two types of mutations occur as a combination. Under low gene expression
    demand, negative epistasis between the two types of mutations renders them mutually
    exclusive. Thus, owing to their higher frequency, adaptation is dominated by copy-number
    mutations. Ultimately, due to high rates of reversal and pleiotropic cost, copy-number
    mutations may not only serve as a crude and transient adaptation but also constrain
    sequence divergence over evolutionary time scales.'
article_processing_charge: No
author:
- first_name: Isabella
  full_name: Tomanek, Isabella
  id: 3981F020-F248-11E8-B48F-1D18A9856A87
  last_name: Tomanek
  orcid: 0000-0001-6197-363X
- first_name: Calin C
  full_name: Guet, Calin C
  id: 47F8433E-F248-11E8-B48F-1D18A9856A87
  last_name: Guet
  orcid: 0000-0001-6220-2052
citation:
  ama: Tomanek I, Guet CC. Flow cytometry YFP and CFP data and deep sequencing data
    of populations evolving in galactose. 2022. doi:<a href="https://doi.org/10.5061/dryad.rfj6q57ds">10.5061/dryad.rfj6q57ds</a>
  apa: Tomanek, I., &#38; Guet, C. C. (2022). Flow cytometry YFP and CFP data and
    deep sequencing data of populations evolving in galactose. Dryad. <a href="https://doi.org/10.5061/dryad.rfj6q57ds">https://doi.org/10.5061/dryad.rfj6q57ds</a>
  chicago: Tomanek, Isabella, and Calin C Guet. “Flow Cytometry YFP and CFP Data and
    Deep Sequencing Data of Populations Evolving in Galactose.” Dryad, 2022. <a href="https://doi.org/10.5061/dryad.rfj6q57ds">https://doi.org/10.5061/dryad.rfj6q57ds</a>.
  ieee: I. Tomanek and C. C. Guet, “Flow cytometry YFP and CFP data and deep sequencing
    data of populations evolving in galactose.” Dryad, 2022.
  ista: Tomanek I, Guet CC. 2022. Flow cytometry YFP and CFP data and deep sequencing
    data of populations evolving in galactose, Dryad, <a href="https://doi.org/10.5061/dryad.rfj6q57ds">10.5061/dryad.rfj6q57ds</a>.
  mla: Tomanek, Isabella, and Calin C. Guet. <i>Flow Cytometry YFP and CFP Data and
    Deep Sequencing Data of Populations Evolving in Galactose</i>. Dryad, 2022, doi:<a
    href="https://doi.org/10.5061/dryad.rfj6q57ds">10.5061/dryad.rfj6q57ds</a>.
  short: I. Tomanek, C.C. Guet, (2022).
corr_author: '1'
date_created: 2023-01-23T09:00:37Z
date_published: 2022-12-23T00:00:00Z
date_updated: 2025-03-06T14:03:50Z
day: '23'
ddc:
- '570'
department:
- _id: CaGu
doi: 10.5061/dryad.rfj6q57ds
fulldoi: https://doi.org/10.5061/dryad.rfj6q57ds
main_file_link:
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  url: https://doi.org/10.5061/dryad.rfj6q57ds
month: '12'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
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    relation: used_in_publication
    status: public
status: public
title: Flow cytometry YFP and CFP data and deep sequencing data of populations evolving
  in galactose
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
OA_place: publisher
_id: '12358'
abstract:
- lang: eng
  text: "The complex yarn structure of knitted and woven fabrics gives rise to both
    a mechanical and\r\nvisual complexity. The small-scale interactions of yarns colliding
    with and pulling on each\r\nother result in drastically different large-scale
    stretching and bending behavior, introducing\r\nanisotropy, curling, and more.
    While simulating cloth as individual yarns can reproduce this\r\ncomplexity and
    match the quality of real fabric, it may be too computationally expensive for\r\nlarge
    fabrics. On the other hand, continuum-based approaches do not need to discretize
    the\r\ncloth at a stitch-level, but it is non-trivial to find a material model
    that would replicate the\r\nlarge-scale behavior of yarn fabrics, and they discard
    the intricate visual detail. In this thesis,\r\nwe discuss three methods to try
    and bridge the gap between small-scale and large-scale yarn\r\nmechanics using
    numerical homogenization: fitting a continuum model to periodic yarn simulations,
    adding mechanics-aware yarn detail onto thin-shell simulations, and quantitatively\r\nfitting
    yarn parameters to physical measurements of real fabric.\r\nTo start, we present
    a method for animating yarn-level cloth effects using a thin-shell solver.\r\nWe
    first use a large number of periodic yarn-level simulations to build a model of
    the potential\r\nenergy density of the cloth, and then use it to compute forces
    in a thin-shell simulator. The\r\nresulting simulations faithfully reproduce expected
    effects like the stiffening of woven fabrics\r\nand the highly deformable nature
    and anisotropy of knitted fabrics at a fraction of the cost of\r\nfull yarn-level
    simulation.\r\nWhile our thin-shell simulations are able to capture large-scale
    yarn mechanics, they lack\r\nthe rich visual detail of yarn-level simulations.
    Therefore, we propose a method to animate\r\nyarn-level cloth geometry on top
    of an underlying deforming mesh in a mechanics-aware\r\nfashion in real time.
    Using triangle strains to interpolate precomputed yarn geometry, we are\r\nable
    to reproduce effects such as knit loops tightening under stretching at negligible
    cost.\r\nFinally, we introduce a methodology for inverse-modeling of yarn-level
    mechanics of cloth,\r\nbased on the mechanical response of fabrics in the real
    world. We compile a database from\r\nphysical tests of several knitted fabrics
    used in the textile industry spanning diverse physical\r\nproperties like stiffness,
    nonlinearity, and anisotropy. We then develop a system for approximating these
    mechanical responses with yarn-level cloth simulation, using homogenized\r\nshell
    models to speed up computation and adding some small-but-necessary extensions
    to\r\nyarn-level models used in computer graphics.\r\n"
acknowledged_ssus:
- _id: SSU
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Georg
  full_name: Sperl, Georg
  id: 4DD40360-F248-11E8-B48F-1D18A9856A87
  last_name: Sperl
citation:
  ama: 'Sperl G. Homogenizing yarn simulations: Large-scale mechanics, small-scale
    detail, and quantitative fitting. 2022. doi:<a href="https://doi.org/10.15479/at:ista:12103">10.15479/at:ista:12103</a>'
  apa: 'Sperl, G. (2022). <i>Homogenizing yarn simulations: Large-scale mechanics,
    small-scale detail, and quantitative fitting</i>. Institute of Science and Technology
    Austria. <a href="https://doi.org/10.15479/at:ista:12103">https://doi.org/10.15479/at:ista:12103</a>'
  chicago: 'Sperl, Georg. “Homogenizing Yarn Simulations: Large-Scale Mechanics, Small-Scale
    Detail, and Quantitative Fitting.” Institute of Science and Technology Austria,
    2022. <a href="https://doi.org/10.15479/at:ista:12103">https://doi.org/10.15479/at:ista:12103</a>.'
  ieee: 'G. Sperl, “Homogenizing yarn simulations: Large-scale mechanics, small-scale
    detail, and quantitative fitting,” Institute of Science and Technology Austria,
    2022.'
  ista: 'Sperl G. 2022. Homogenizing yarn simulations: Large-scale mechanics, small-scale
    detail, and quantitative fitting. Institute of Science and Technology Austria.'
  mla: 'Sperl, Georg. <i>Homogenizing Yarn Simulations: Large-Scale Mechanics, Small-Scale
    Detail, and Quantitative Fitting</i>. Institute of Science and Technology Austria,
    2022, doi:<a href="https://doi.org/10.15479/at:ista:12103">10.15479/at:ista:12103</a>.'
  short: 'G. Sperl, Homogenizing Yarn Simulations: Large-Scale Mechanics, Small-Scale
    Detail, and Quantitative Fitting, Institute of Science and Technology Austria,
    2022.'
corr_author: '1'
date_created: 2023-01-24T10:49:46Z
date_published: 2022-09-22T00:00:00Z
date_updated: 2026-06-18T19:57:47Z
day: '22'
ddc:
- '000'
- '620'
degree_awarded: PhD
department:
- _id: GradSch
- _id: ChWo
doi: 10.15479/at:ista:12103
ec_funded: 1
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has_accepted_license: '1'
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month: '09'
oa: 1
oa_version: Published Version
page: '138'
project:
- _id: 2533E772-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '638176'
  name: 'Big Splash: Efficient Simulation of Natural Phenomena at Extremely Large
    Scales'
publication_identifier:
  isbn:
  - 978-3-99078-020-6
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
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  - id: '11736'
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status: public
supervisor:
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  full_name: Wojtan, Christopher J
  id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
  last_name: Wojtan
  orcid: 0000-0001-6646-5546
title: 'Homogenizing yarn simulations: Large-scale mechanics, small-scale detail,
  and quantitative fitting'
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2022'
...
