---
_id: '18211'
abstract:
- lang: eng
  text: 'Deep neural networks are known to be vulnerable to malicious perturbations.
    Current methods for improving adversarial robustness make use of either implicit
    or explicit regularization, with the latter is usually based on adversarial training.
    Randomized smoothing, the averaging of the classifier outputs over a random distribution
    centered in the sample, has been shown to guarantee a classifier’s performance
    subject to bounded perturbations of the input. In this work, we study the application
    of randomized smoothing to improve performance on unperturbed data and increase
    robustness to adversarial attacks. We propose to combine smoothing along with
    adversarial training and randomization approaches, and find that doing so significantly
    improves the resilience compared to the baseline. We examine our method’s performance
    on common whitebox (FGSM, PGD) and black-box (transferable attack and NAttack)
    attacks on CIFAR-10 and CIFAR-100, and determine that for a low number of iterations,
    smoothing provides a significant performance boost that persists even for perturbations
    with a high attack norm, . For example, under a PGD-10 attack on CIFAR-10 using
    Wide-ResNet28-4, we achieve 60.3% accuracy for infinity norm ∞ = 8/255 and 13.1%
    accuracy for ∞ = 35/255 – outperforming previous art by 3% and 6%, respectively.
    We achieve nearly twice the accuracy on ∞ = 35/255 and even more so for perturbations
    with higher infinity norm. A reference implementation of the proposed method is
    provided. '
article_processing_charge: No
article_type: original
author:
- first_name: Yaniv
  full_name: Nemcovsky, Yaniv
  last_name: Nemcovsky
- first_name: Evgenii
  full_name: Zheltonozhskii, Evgenii
  last_name: Zheltonozhskii
- first_name: Chaim
  full_name: Baskin, Chaim
  last_name: Baskin
- first_name: Brian
  full_name: Chmiel, Brian
  last_name: Chmiel
- first_name: Alexander
  full_name: Bronstein, Alexander
  id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6
  last_name: Bronstein
  orcid: 0000-0001-9699-8730
- first_name: Avi
  full_name: Mendelson, Avi
  last_name: Mendelson
citation:
  ama: Nemcovsky Y, Zheltonozhskii E, Baskin C, Chmiel B, Bronstein AM, Mendelson
    A. Adversarial robustness via noise injection in smoothed models. <i>Applied Intelligence</i>.
    2022;53(8):9483-9498. doi:<a href="https://doi.org/10.1007/s10489-022-03423-5">10.1007/s10489-022-03423-5</a>
  apa: Nemcovsky, Y., Zheltonozhskii, E., Baskin, C., Chmiel, B., Bronstein, A. M.,
    &#38; Mendelson, A. (2022). Adversarial robustness via noise injection in smoothed
    models. <i>Applied Intelligence</i>. Springer Nature. <a href="https://doi.org/10.1007/s10489-022-03423-5">https://doi.org/10.1007/s10489-022-03423-5</a>
  chicago: Nemcovsky, Yaniv, Evgenii Zheltonozhskii, Chaim Baskin, Brian Chmiel, Alex
    M. Bronstein, and Avi Mendelson. “Adversarial Robustness via Noise Injection in
    Smoothed Models.” <i>Applied Intelligence</i>. Springer Nature, 2022. <a href="https://doi.org/10.1007/s10489-022-03423-5">https://doi.org/10.1007/s10489-022-03423-5</a>.
  ieee: Y. Nemcovsky, E. Zheltonozhskii, C. Baskin, B. Chmiel, A. M. Bronstein, and
    A. Mendelson, “Adversarial robustness via noise injection in smoothed models,”
    <i>Applied Intelligence</i>, vol. 53, no. 8. Springer Nature, pp. 9483–9498, 2022.
  ista: Nemcovsky Y, Zheltonozhskii E, Baskin C, Chmiel B, Bronstein AM, Mendelson
    A. 2022. Adversarial robustness via noise injection in smoothed models. Applied
    Intelligence. 53(8), 9483–9498.
  mla: Nemcovsky, Yaniv, et al. “Adversarial Robustness via Noise Injection in Smoothed
    Models.” <i>Applied Intelligence</i>, vol. 53, no. 8, Springer Nature, 2022, pp.
    9483–98, doi:<a href="https://doi.org/10.1007/s10489-022-03423-5">10.1007/s10489-022-03423-5</a>.
  short: Y. Nemcovsky, E. Zheltonozhskii, C. Baskin, B. Chmiel, A.M. Bronstein, A.
    Mendelson, Applied Intelligence 53 (2022) 9483–9498.
date_created: 2024-10-08T12:47:53Z
date_published: 2022-08-09T00:00:00Z
date_updated: 2024-10-09T11:04:54Z
day: '09'
doi: 10.1007/s10489-022-03423-5
extern: '1'
intvolume: '        53'
issue: '8'
language:
- iso: eng
month: '08'
oa_version: None
page: 9483-9498
publication: Applied Intelligence
publication_identifier:
  eissn:
  - 1573-7497
  issn:
  - 0924-669X
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Adversarial robustness via noise injection in smoothed models
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 53
year: '2022'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '18220'
abstract:
- lang: eng
  text: Synonymous codons translate into the same amino acid. Although the identity
    of synonymous codons is often considered inconsequential to the final protein
    structure, there is mounting evidence for an association between the two. Our
    study examined this association using regression and classification models, finding
    that codon sequences predict protein backbone dihedral angles with a lower error
    than amino acid sequences, and that models trained with true dihedral angles have
    better classification of synonymous codons given structural information than models
    trained with random dihedral angles. Using this classification approach, we investigated
    local codon–codon dependencies and tested whether synonymous codon identity can
    be predicted more accurately from codon context than amino acid context alone,
    and most specifically which codon context position carries the most predictive
    power.
article_number: '21968'
article_processing_charge: Yes
article_type: original
author:
- first_name: Linor
  full_name: Ackerman-Schraier, Linor
  last_name: Ackerman-Schraier
- first_name: Aviv A.
  full_name: Rosenberg, Aviv A.
  last_name: Rosenberg
- first_name: Ailie
  full_name: Marx, Ailie
  last_name: Marx
- first_name: Alexander
  full_name: Bronstein, Alexander
  id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6
  last_name: Bronstein
  orcid: 0000-0001-9699-8730
citation:
  ama: Ackerman-Schraier L, Rosenberg AA, Marx A, Bronstein AM. Machine learning approaches
    demonstrate that protein structures carry information about their genetic coding.
    <i>Scientific Reports</i>. 2022;12. doi:<a href="https://doi.org/10.1038/s41598-022-25874-z">10.1038/s41598-022-25874-z</a>
  apa: Ackerman-Schraier, L., Rosenberg, A. A., Marx, A., &#38; Bronstein, A. M. (2022).
    Machine learning approaches demonstrate that protein structures carry information
    about their genetic coding. <i>Scientific Reports</i>. Springer Nature. <a href="https://doi.org/10.1038/s41598-022-25874-z">https://doi.org/10.1038/s41598-022-25874-z</a>
  chicago: Ackerman-Schraier, Linor, Aviv A. Rosenberg, Ailie Marx, and Alex M. Bronstein.
    “Machine Learning Approaches Demonstrate That Protein Structures Carry Information
    about Their Genetic Coding.” <i>Scientific Reports</i>. Springer Nature, 2022.
    <a href="https://doi.org/10.1038/s41598-022-25874-z">https://doi.org/10.1038/s41598-022-25874-z</a>.
  ieee: L. Ackerman-Schraier, A. A. Rosenberg, A. Marx, and A. M. Bronstein, “Machine
    learning approaches demonstrate that protein structures carry information about
    their genetic coding,” <i>Scientific Reports</i>, vol. 12. Springer Nature, 2022.
  ista: Ackerman-Schraier L, Rosenberg AA, Marx A, Bronstein AM. 2022. Machine learning
    approaches demonstrate that protein structures carry information about their genetic
    coding. Scientific Reports. 12, 21968.
  mla: Ackerman-Schraier, Linor, et al. “Machine Learning Approaches Demonstrate That
    Protein Structures Carry Information about Their Genetic Coding.” <i>Scientific
    Reports</i>, vol. 12, 21968, Springer Nature, 2022, doi:<a href="https://doi.org/10.1038/s41598-022-25874-z">10.1038/s41598-022-25874-z</a>.
  short: L. Ackerman-Schraier, A.A. Rosenberg, A. Marx, A.M. Bronstein, Scientific
    Reports 12 (2022).
date_created: 2024-10-08T12:52:29Z
date_published: 2022-12-20T00:00:00Z
date_updated: 2024-10-14T09:46:06Z
day: '20'
doi: 10.1038/s41598-022-25874-z
extern: '1'
external_id:
  pmid:
  - '36539476'
intvolume: '        12'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1038/s41598-022-25874-z
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
publication: Scientific Reports
publication_identifier:
  issn:
  - 2045-2322
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Machine learning approaches demonstrate that protein structures carry information
  about their genetic coding
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2022'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '18221'
abstract:
- lang: eng
  text: Synonymous codons translate into chemically identical amino acids. Once considered
    inconsequential to the formation of the protein product, there is evidence to
    suggest that codon usage affects co-translational protein folding and the final
    structure of the expressed protein. Here we develop a method for computing and
    comparing codon-specific Ramachandran plots and demonstrate that the backbone
    dihedral angle distributions of some synonymous codons are distinguishable with
    statistical significance for some secondary structures. This shows that there
    exists a dependence between codon identity and backbone torsion of the translated
    amino acid. Although these findings cannot pinpoint the causal direction of this
    dependence, we discuss the vast biological implications should coding be shown
    to directly shape protein conformation and demonstrate the usefulness of this
    method as a tool for probing associations between codon usage and protein structure.
    Finally, we urge for the inclusion of exact genetic information into structural
    databases.
article_number: '2815'
article_processing_charge: Yes
article_type: original
author:
- first_name: Aviv A.
  full_name: Rosenberg, Aviv A.
  last_name: Rosenberg
- first_name: Ailie
  full_name: Marx, Ailie
  last_name: Marx
- first_name: Alexander
  full_name: Bronstein, Alexander
  id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6
  last_name: Bronstein
  orcid: 0000-0001-9699-8730
citation:
  ama: Rosenberg AA, Marx A, Bronstein AM. Codon-specific Ramachandran plots show
    amino acid backbone conformation depends on identity of the translated codon.
    <i>Nature Communications</i>. 2022;13. doi:<a href="https://doi.org/10.1038/s41467-022-30390-9">10.1038/s41467-022-30390-9</a>
  apa: Rosenberg, A. A., Marx, A., &#38; Bronstein, A. M. (2022). Codon-specific Ramachandran
    plots show amino acid backbone conformation depends on identity of the translated
    codon. <i>Nature Communications</i>. Springer Nature. <a href="https://doi.org/10.1038/s41467-022-30390-9">https://doi.org/10.1038/s41467-022-30390-9</a>
  chicago: Rosenberg, Aviv A., Ailie Marx, and Alex M. Bronstein. “Codon-Specific
    Ramachandran Plots Show Amino Acid Backbone Conformation Depends on Identity of
    the Translated Codon.” <i>Nature Communications</i>. Springer Nature, 2022. <a
    href="https://doi.org/10.1038/s41467-022-30390-9">https://doi.org/10.1038/s41467-022-30390-9</a>.
  ieee: A. A. Rosenberg, A. Marx, and A. M. Bronstein, “Codon-specific Ramachandran
    plots show amino acid backbone conformation depends on identity of the translated
    codon,” <i>Nature Communications</i>, vol. 13. Springer Nature, 2022.
  ista: Rosenberg AA, Marx A, Bronstein AM. 2022. Codon-specific Ramachandran plots
    show amino acid backbone conformation depends on identity of the translated codon.
    Nature Communications. 13, 2815.
  mla: Rosenberg, Aviv A., et al. “Codon-Specific Ramachandran Plots Show Amino Acid
    Backbone Conformation Depends on Identity of the Translated Codon.” <i>Nature
    Communications</i>, vol. 13, 2815, Springer Nature, 2022, doi:<a href="https://doi.org/10.1038/s41467-022-30390-9">10.1038/s41467-022-30390-9</a>.
  short: A.A. Rosenberg, A. Marx, A.M. Bronstein, Nature Communications 13 (2022).
date_created: 2024-10-08T12:53:01Z
date_published: 2022-05-20T00:00:00Z
date_updated: 2024-10-14T09:49:02Z
day: '20'
doi: 10.1038/s41467-022-30390-9
extern: '1'
external_id:
  pmid:
  - '35595777'
intvolume: '        13'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1038/s41467-022-30390-9
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
  issn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Codon-specific Ramachandran plots show amino acid backbone conformation depends
  on identity of the translated codon
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2022'
...
---
OA_place: publisher
OA_type: free access
_id: '18222'
abstract:
- lang: eng
  text: "STUDY QUESTION: What is the accuracy and agreement of embryologists when
    assessing the implantation probability of blastocysts using time-lapse imaging
    (TLI), and can it be improved with a data-driven algorithm?\r\n\r\nSUMMARY ANSWER:
    The overall interobserver agreement of a large panel of embryologists was moderate
    and prediction accuracy was modest, while the purpose-built artificial intelligence
    model generally resulted in higher performance metrics.\r\n\r\nWHAT IS KNOWN ALREADY:
    Previous studies have demonstrated significant interobserver variability amongst
    embryologists when assessing embryo quality. However, data concerning embryologists’
    ability to predict implantation probability using TLI is still lacking. Emerging
    technologies based on data-driven tools have shown great promise for improving
    embryo selection and predicting clinical outcomes.\r\n\r\nSTUDY DESIGN, SIZE,
    DURATION: TLI video files of 136 embryos with known implantation data were retrospectively
    collected from two clinical sites between 2018 and 2019 for the performance assessment
    of 36 embryologists and comparison with a deep neural network (DNN).\r\n\r\nPARTICIPANTS/MATERIALS,
    SETTING, METHODS: We recruited 39 embryologists from 13 different countries. All
    participants were blinded to clinical outcomes. A total of 136 TLI videos of embryos
    that reached the blastocyst stage were used for this experiment. Each embryo’s
    likelihood of successfully implanting was assessed by 36 embryologists, providing
    implantation probability grades (IPGs) from 1 to 5, where 1 indicates a very low
    likelihood of implantation and 5 indicates a very high likelihood. Subsequently,
    three embryologists with over 5 years of experience provided Gardner scores. All
    136 blastocysts were categorized into three quality groups based on their Gardner
    scores. Embryologist predictions were then converted into predictions of implantation
    (IPG ≥ 3) and no implantation (IPG ≤ 2). Embryologists’ performance and agreement
    were assessed using Fleiss kappa coefficient. A 10-fold cross-validation DNN was
    developed to provide IPGs for TLI video files. The model’s performance was compared
    to that of the embryologists.\r\n\r\nMAIN RESULTS AND THE ROLE OF CHANCE: Logistic
    regression was employed for the following confounding variables: country of residence,
    academic level, embryo scoring system, log years of experience and experience
    using TLI. None were found to have a statistically significant impact on embryologist
    performance at α = 0.05. The average implantation prediction accuracy for the
    embryologists was 51.9% for all embryos (N = 136). The average accuracy of the
    embryologists when assessing top quality and poor quality embryos (according to
    the Gardner score categorizations) was 57.5% and 57.4%, respectively, and 44.6%
    for fair quality embryos. Overall interobserver agreement was moderate (κ = 0.56,
    N = 136). The best agreement was achieved in the poor + top quality group (κ = 0.65,
    N = 77), while the agreement in the fair quality group was lower (κ = 0.25, N = 59).
    The DNN showed an overall accuracy rate of 62.5%, with accuracies of 62.2%, 61%
    and 65.6% for the poor, fair and top quality groups, respectively. The AUC for
    the DNN was higher than that of the embryologists overall (0.70 DNN vs 0.61 embryologists)
    as well as in all of the Gardner groups (DNN vs embryologists—Poor: 0.69 vs 0.62;
    Fair: 0.67 vs 0.53; Top: 0.77 vs 0.54).\r\n\r\nLIMITATIONS, REASONS FOR CAUTION:
    Blastocyst assessment was performed using video files acquired from time-lapse
    incubators, where each video contained data from a single focal plane. Clinical
    data regarding the underlying cause of infertility and endometrial thickness before
    the transfer was not available, yet may explain implantation failure and lower
    accuracy of IPGs. Implantation was defined as the presence of a gestational sac,
    whereas the detection of fetal heartbeat is a more robust marker of embryo viability.
    The raw data were anonymized to the extent that it was not possible to quantify
    the number of unique patients and cycles included in the study, potentially masking
    the effect of bias from a limited patient pool. Furthermore, the lack of demographic
    data makes it difficult to draw conclusions on how representative the dataset
    was of the wider population. Finally, embryologists were required to assess the
    implantation potential, not embryo quality. Although this is not the traditional
    approach to embryo evaluation, morphology/morphokinetics as a means of assessing
    embryo quality is believed to be strongly correlated with viability and, for some
    methods, implantation potential.\r\n\r\nWIDER IMPLICATIONS OF THE FINDINGS: Embryo
    selection is a key element in IVF success and continues to be a challenge. Improving
    the predictive ability could assist in optimizing implantation success rates and
    other clinical outcomes and could minimize the financial and emotional burden
    on the patient. This study demonstrates moderate agreement rates between embryologists,
    likely due to the subjective nature of embryo assessment. In particular, we found
    that average embryologist accuracy and agreement were significantly lower for
    fair quality embryos when compared with that for top and poor quality embryos.
    Using data-driven algorithms as an assistive tool may help IVF professionals increase
    success rates and promote much needed standardization in the IVF clinic. Our results
    indicate a need for further research regarding technological advancement in this
    field."
article_processing_charge: No
article_type: original
author:
- first_name: Daniel E
  full_name: Fordham, Daniel E
  last_name: Fordham
- first_name: Dror
  full_name: Rosentraub, Dror
  last_name: Rosentraub
- first_name: Avital L
  full_name: Polsky, Avital L
  last_name: Polsky
- first_name: Talia
  full_name: Aviram, Talia
  last_name: Aviram
- first_name: Yotam
  full_name: Wolf, Yotam
  last_name: Wolf
- first_name: Oriel
  full_name: Perl, Oriel
  last_name: Perl
- first_name: Asnat
  full_name: Devir, Asnat
  last_name: Devir
- first_name: Shahar
  full_name: Rosentraub, Shahar
  last_name: Rosentraub
- first_name: David H
  full_name: Silver, David H
  last_name: Silver
- first_name: Yael
  full_name: Gold Zamir, Yael
  last_name: Gold Zamir
- first_name: Alexander
  full_name: Bronstein, Alexander
  id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6
  last_name: Bronstein
  orcid: 0000-0001-9699-8730
- first_name: Miguel
  full_name: Lara Lara, Miguel
  last_name: Lara Lara
- first_name: Jara
  full_name: Ben Nagi, Jara
  last_name: Ben Nagi
- first_name: Adrian
  full_name: Alvarez, Adrian
  last_name: Alvarez
- first_name: Santiago
  full_name: Munné, Santiago
  last_name: Munné
citation:
  ama: 'Fordham DE, Rosentraub D, Polsky AL, et al. Embryologist agreement when assessing
    blastocyst implantation probability: Is data-driven prediction the solution to
    embryo assessment subjectivity? <i>Human Reproduction</i>. 2022;37(10):2275-2290.
    doi:<a href="https://doi.org/10.1093/humrep/deac171">10.1093/humrep/deac171</a>'
  apa: 'Fordham, D. E., Rosentraub, D., Polsky, A. L., Aviram, T., Wolf, Y., Perl,
    O., … Munné, S. (2022). Embryologist agreement when assessing blastocyst implantation
    probability: Is data-driven prediction the solution to embryo assessment subjectivity?
    <i>Human Reproduction</i>. Oxford University Press. <a href="https://doi.org/10.1093/humrep/deac171">https://doi.org/10.1093/humrep/deac171</a>'
  chicago: 'Fordham, Daniel E, Dror Rosentraub, Avital L Polsky, Talia Aviram, Yotam
    Wolf, Oriel Perl, Asnat Devir, et al. “Embryologist Agreement When Assessing Blastocyst
    Implantation Probability: Is Data-Driven Prediction the Solution to Embryo Assessment
    Subjectivity?” <i>Human Reproduction</i>. Oxford University Press, 2022. <a href="https://doi.org/10.1093/humrep/deac171">https://doi.org/10.1093/humrep/deac171</a>.'
  ieee: 'D. E. Fordham <i>et al.</i>, “Embryologist agreement when assessing blastocyst
    implantation probability: Is data-driven prediction the solution to embryo assessment
    subjectivity?,” <i>Human Reproduction</i>, vol. 37, no. 10. Oxford University
    Press, pp. 2275–2290, 2022.'
  ista: 'Fordham DE, Rosentraub D, Polsky AL, Aviram T, Wolf Y, Perl O, Devir A, Rosentraub
    S, Silver DH, Gold Zamir Y, Bronstein AM, Lara Lara M, Ben Nagi J, Alvarez A,
    Munné S. 2022. Embryologist agreement when assessing blastocyst implantation probability:
    Is data-driven prediction the solution to embryo assessment subjectivity? Human
    Reproduction. 37(10), 2275–2290.'
  mla: 'Fordham, Daniel E., et al. “Embryologist Agreement When Assessing Blastocyst
    Implantation Probability: Is Data-Driven Prediction the Solution to Embryo Assessment
    Subjectivity?” <i>Human Reproduction</i>, vol. 37, no. 10, Oxford University Press,
    2022, pp. 2275–90, doi:<a href="https://doi.org/10.1093/humrep/deac171">10.1093/humrep/deac171</a>.'
  short: D.E. Fordham, D. Rosentraub, A.L. Polsky, T. Aviram, Y. Wolf, O. Perl, A.
    Devir, S. Rosentraub, D.H. Silver, Y. Gold Zamir, A.M. Bronstein, M. Lara Lara,
    J. Ben Nagi, A. Alvarez, S. Munné, Human Reproduction 37 (2022) 2275–2290.
date_created: 2024-10-08T12:53:20Z
date_published: 2022-10-01T00:00:00Z
date_updated: 2024-10-14T09:54:40Z
day: '01'
doi: 10.1093/humrep/deac171
extern: '1'
intvolume: '        37'
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1093/humrep/deac171
month: '10'
oa: 1
oa_version: Published Version
page: 2275-2290
publication: Human Reproduction
publication_identifier:
  eissn:
  - 1460-2350
  issn:
  - 0268-1161
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Embryologist agreement when assessing blastocyst implantation probability:
  Is data-driven prediction the solution to embryo assessment subjectivity?'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 37
year: '2022'
...
---
OA_type: closed access
_id: '18223'
abstract:
- lang: eng
  text: The term silent mutation is commonly used to describe (1) a change in the
    DNA sequence that does not result in an observable effect on the organism’s phenotype;
    and (2) a synonymous mutation where the nucleotide change leaves the translated
    amino acid sequence unchanged. When Christian Anfinsen showed that a folded and
    active protein could be denatured to lose structure and activity and then subsequently
    renatured to regain the same structure and activity it appeared that the native,
    thermodynamically stable, structure of a protein depends only on the amino acid
    sequence and solution conditions (Anfinsen and Haber 1961). This experiment suggested
    that, once translated, proteins carry no memory of the genetic sequence and led
    to one of the most erroneous assumptions in modern science; synonymous codons
    were long considered silent, a mutation of the type that has no effect on an organism’s
    phenotype.
article_processing_charge: No
author:
- first_name: Aviv A.
  full_name: Rosenberg, Aviv A.
  last_name: Rosenberg
- first_name: Alexander
  full_name: Bronstein, Alexander
  id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6
  last_name: Bronstein
  orcid: 0000-0001-9699-8730
- first_name: Ailie
  full_name: Marx, Ailie
  last_name: Marx
citation:
  ama: 'Rosenberg AA, Bronstein AM, Marx A. Recording Silence – Accurate Annotation
    of the Genetic Sequence Is Required to Better Understand How Synonymous Coding
    Affects Protein Structure and Disease. In: Sauna ZE, Kimchi-Sarfaty C, eds. <i>Single
    Nucleotide Polymorphisms</i>. Cham: Springer Nature; 2022:37-47. doi:<a href="https://doi.org/10.1007/978-3-031-05616-1_3">10.1007/978-3-031-05616-1_3</a>'
  apa: 'Rosenberg, A. A., Bronstein, A. M., &#38; Marx, A. (2022). Recording Silence
    – Accurate Annotation of the Genetic Sequence Is Required to Better Understand
    How Synonymous Coding Affects Protein Structure and Disease. In Z. E. Sauna &#38;
    C. Kimchi-Sarfaty (Eds.), <i>Single Nucleotide Polymorphisms</i> (pp. 37–47).
    Cham: Springer Nature. <a href="https://doi.org/10.1007/978-3-031-05616-1_3">https://doi.org/10.1007/978-3-031-05616-1_3</a>'
  chicago: 'Rosenberg, Aviv A., Alex M. Bronstein, and Ailie Marx. “Recording Silence
    – Accurate Annotation of the Genetic Sequence Is Required to Better Understand
    How Synonymous Coding Affects Protein Structure and Disease.” In <i>Single Nucleotide
    Polymorphisms</i>, edited by Zuben E. Sauna and Chava Kimchi-Sarfaty, 37–47. Cham:
    Springer Nature, 2022. <a href="https://doi.org/10.1007/978-3-031-05616-1_3">https://doi.org/10.1007/978-3-031-05616-1_3</a>.'
  ieee: 'A. A. Rosenberg, A. M. Bronstein, and A. Marx, “Recording Silence – Accurate
    Annotation of the Genetic Sequence Is Required to Better Understand How Synonymous
    Coding Affects Protein Structure and Disease,” in <i>Single Nucleotide Polymorphisms</i>,
    Z. E. Sauna and C. Kimchi-Sarfaty, Eds. Cham: Springer Nature, 2022, pp. 37–47.'
  ista: 'Rosenberg AA, Bronstein AM, Marx A. 2022.Recording Silence – Accurate Annotation
    of the Genetic Sequence Is Required to Better Understand How Synonymous Coding
    Affects Protein Structure and Disease. In: Single Nucleotide Polymorphisms. ,
    37–47.'
  mla: Rosenberg, Aviv A., et al. “Recording Silence – Accurate Annotation of the
    Genetic Sequence Is Required to Better Understand How Synonymous Coding Affects
    Protein Structure and Disease.” <i>Single Nucleotide Polymorphisms</i>, edited
    by Zuben E. Sauna and Chava Kimchi-Sarfaty, Springer Nature, 2022, pp. 37–47,
    doi:<a href="https://doi.org/10.1007/978-3-031-05616-1_3">10.1007/978-3-031-05616-1_3</a>.
  short: A.A. Rosenberg, A.M. Bronstein, A. Marx, in:, Z.E. Sauna, C. Kimchi-Sarfaty
    (Eds.), Single Nucleotide Polymorphisms, Springer Nature, Cham, 2022, pp. 37–47.
date_created: 2024-10-08T12:53:44Z
date_published: 2022-08-10T00:00:00Z
date_updated: 2024-10-14T09:58:21Z
day: '10'
doi: 10.1007/978-3-031-05616-1_3
editor:
- first_name: Zuben E.
  full_name: Sauna, Zuben E.
  last_name: Sauna
- first_name: Chava
  full_name: Kimchi-Sarfaty, Chava
  last_name: Kimchi-Sarfaty
extern: '1'
language:
- iso: eng
month: '08'
oa_version: None
page: 37-47
place: Cham
publication: Single Nucleotide Polymorphisms
publication_identifier:
  eisbn:
  - '9783031056161'
  isbn:
  - '9783031056147'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Recording Silence – Accurate Annotation of the Genetic Sequence Is Required
  to Better Understand How Synonymous Coding Affects Protein Structure and Disease
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
OA_place: repository
_id: '18224'
abstract:
- lang: eng
  text: Learning from one or few visual examples is one of the key capabilities of
    humans since early infancy, but is still a significant challenge for modern AI
    systems. While considerable progress has been achieved in few-shot learning from
    a few image examples, much less attention has been given to the verbal descriptions
    that are usually provided to infants when they are presented with a new object.
    In this paper, we focus on the role of additional semantics that can significantly
    facilitate few-shot visual learning. Building upon recent advances in few-shot
    learning with additional semantic information, we demonstrate that further improvements
    are possible by combining multiple and richer semantics (category labels, attributes,
    and natural language descriptions). Using these ideas, we offer the community
    new results on the popular miniImageNet and CUB few-shot benchmarks, comparing
    favorably to the previous state-of-the-art results for both visual only and visual
    plus semantics-based approaches. We also performed an ablation study investigating
    the components and design choices of our approach. Code available on github.com/EliSchwartz/mutiple-semantics.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Eli
  full_name: Schwartz, Eli
  last_name: Schwartz
- first_name: Leonid
  full_name: Karlinsky, Leonid
  last_name: Karlinsky
- first_name: Rogerio
  full_name: Feris, Rogerio
  last_name: Feris
- first_name: Raja
  full_name: Giryes, Raja
  last_name: Giryes
- first_name: Alexander
  full_name: Bronstein, Alexander
  id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6
  last_name: Bronstein
  orcid: 0000-0001-9699-8730
citation:
  ama: Schwartz E, Karlinsky L, Feris R, Giryes R, Bronstein AM. Baby steps towards
    few-shot learning with multiple semantics. <i>Pattern Recognition Letters</i>.
    2022;160:142-147. doi:<a href="https://doi.org/10.1016/j.patrec.2022.06.012">10.1016/j.patrec.2022.06.012</a>
  apa: Schwartz, E., Karlinsky, L., Feris, R., Giryes, R., &#38; Bronstein, A. M.
    (2022). Baby steps towards few-shot learning with multiple semantics. <i>Pattern
    Recognition Letters</i>. Elsevier. <a href="https://doi.org/10.1016/j.patrec.2022.06.012">https://doi.org/10.1016/j.patrec.2022.06.012</a>
  chicago: Schwartz, Eli, Leonid Karlinsky, Rogerio Feris, Raja Giryes, and Alex M.
    Bronstein. “Baby Steps towards Few-Shot Learning with Multiple Semantics.” <i>Pattern
    Recognition Letters</i>. Elsevier, 2022. <a href="https://doi.org/10.1016/j.patrec.2022.06.012">https://doi.org/10.1016/j.patrec.2022.06.012</a>.
  ieee: E. Schwartz, L. Karlinsky, R. Feris, R. Giryes, and A. M. Bronstein, “Baby
    steps towards few-shot learning with multiple semantics,” <i>Pattern Recognition
    Letters</i>, vol. 160. Elsevier, pp. 142–147, 2022.
  ista: Schwartz E, Karlinsky L, Feris R, Giryes R, Bronstein AM. 2022. Baby steps
    towards few-shot learning with multiple semantics. Pattern Recognition Letters.
    160, 142–147.
  mla: Schwartz, Eli, et al. “Baby Steps towards Few-Shot Learning with Multiple Semantics.”
    <i>Pattern Recognition Letters</i>, vol. 160, Elsevier, 2022, pp. 142–47, doi:<a
    href="https://doi.org/10.1016/j.patrec.2022.06.012">10.1016/j.patrec.2022.06.012</a>.
  short: E. Schwartz, L. Karlinsky, R. Feris, R. Giryes, A.M. Bronstein, Pattern Recognition
    Letters 160 (2022) 142–147.
date_created: 2024-10-08T12:54:03Z
date_published: 2022-08-01T00:00:00Z
date_updated: 2024-10-14T10:58:20Z
day: '01'
doi: 10.1016/j.patrec.2022.06.012
extern: '1'
external_id:
  arxiv:
  - '1906.01905'
intvolume: '       160'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1906.01905
month: '08'
oa: 1
oa_version: Preprint
page: 142-147
publication: Pattern Recognition Letters
publication_identifier:
  issn:
  - 0167-8655
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Baby steps towards few-shot learning with multiple semantics
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 160
year: '2022'
...
---
OA_place: publisher
_id: '18225'
abstract:
- lang: eng
  text: "Isometric feature mapping is an established time-honored algorithm in manifold
    learning and non-linear dimensionality reduction. Its prominence can be attributed
    to the output of a coherent global low-dimensional representation of data by preserving
    intrinsic distances. In order to enable an efficient and more applicable isometric
    feature mapping, a diverse set of sophisticated advancements have been proposed
    to the original algorithm to incorporate important factors like sparsity of computation,
    conformality, topological constraints and spectral geometry. However, a significant
    shortcoming of most approaches is the dependence on large-scale dense-spectral
    decompositions and the inability to generalize to points far away from the sampling
    of the manifold.\r\nIn this paper, we explore an unsupervised deep learning approach
    for computing distance-preserving maps for non-linear dimensionality reduction.
    We demonstrate that our framework is general enough to incorporate all previous
    advancements and show a significantly improved local and non-local generalization
    of the isometric mapping. Our approach involves training with only a few landmark
    points and avoids the need for population of dense matrices as well as computing
    their spectral decomposition."
article_number: '104461'
article_processing_charge: No
article_type: original
author:
- first_name: Gautam
  full_name: Pai, Gautam
  last_name: Pai
- first_name: Alexander
  full_name: Bronstein, Alexander
  id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6
  last_name: Bronstein
  orcid: 0000-0001-9699-8730
- first_name: Ronen
  full_name: Talmon, Ronen
  last_name: Talmon
- first_name: Ron
  full_name: Kimmel, Ron
  last_name: Kimmel
citation:
  ama: Pai G, Bronstein AM, Talmon R, Kimmel R. Deep isometric maps. <i>Image and
    Vision Computing</i>. 2022;123. doi:<a href="https://doi.org/10.1016/j.imavis.2022.104461">10.1016/j.imavis.2022.104461</a>
  apa: Pai, G., Bronstein, A. M., Talmon, R., &#38; Kimmel, R. (2022). Deep isometric
    maps. <i>Image and Vision Computing</i>. Elsevier. <a href="https://doi.org/10.1016/j.imavis.2022.104461">https://doi.org/10.1016/j.imavis.2022.104461</a>
  chicago: Pai, Gautam, Alex M. Bronstein, Ronen Talmon, and Ron Kimmel. “Deep Isometric
    Maps.” <i>Image and Vision Computing</i>. Elsevier, 2022. <a href="https://doi.org/10.1016/j.imavis.2022.104461">https://doi.org/10.1016/j.imavis.2022.104461</a>.
  ieee: G. Pai, A. M. Bronstein, R. Talmon, and R. Kimmel, “Deep isometric maps,”
    <i>Image and Vision Computing</i>, vol. 123. Elsevier, 2022.
  ista: Pai G, Bronstein AM, Talmon R, Kimmel R. 2022. Deep isometric maps. Image
    and Vision Computing. 123, 104461.
  mla: Pai, Gautam, et al. “Deep Isometric Maps.” <i>Image and Vision Computing</i>,
    vol. 123, 104461, Elsevier, 2022, doi:<a href="https://doi.org/10.1016/j.imavis.2022.104461">10.1016/j.imavis.2022.104461</a>.
  short: G. Pai, A.M. Bronstein, R. Talmon, R. Kimmel, Image and Vision Computing
    123 (2022).
date_created: 2024-10-08T12:54:22Z
date_published: 2022-07-01T00:00:00Z
date_updated: 2024-10-14T11:03:26Z
day: '01'
doi: 10.1016/j.imavis.2022.104461
extern: '1'
intvolume: '       123'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.imavis.2022.104461
month: '07'
oa: 1
oa_version: Published Version
publication: Image and Vision Computing
publication_identifier:
  issn:
  - 0262-8856
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Deep isometric maps
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 123
year: '2022'
...
---
OA_place: publisher
OA_type: hybrid
_id: '18226'
abstract:
- lang: eng
  text: Spontaneous parametric downconversion (SPDC) in quantum optics is an invaluable
    resource for the realization of high-dimensional qudits with spatial modes of
    light. One of the main open challenges is how to directly generate a desirable
    qudit state in the SPDC process. This problem can be addressed through advanced
    computational learning methods; however, due to difficulties in modeling the SPDC
    process by a fully differentiable algorithm, progress has been limited. Here,
    we overcome these limitations and introduce a physically constrained and differentiable
    model, validated against experimental results for shaped pump beams and structured
    crystals, capable of learning the relevant interaction parameters in the process.
    We avoid any restrictions induced by the stochastic nature of our physical model
    and integrate the dynamic equations governing the evolution under the SPDC Hamiltonian.
    We solve the inverse problem of designing a nonlinear quantum optical system that
    achieves the desired quantum state of downconverted photon pairs. The desired
    states are defined using either the second-order correlations between different
    spatial modes or by specifying the required density matrix. By learning nonlinear
    photonic crystal structures as well as different pump shapes, we successfully
    show how to generate maximally entangled states. Furthermore, we simulate all-optical
    coherent control over the generated quantum state by actively changing the profile
    of the pump beam. Our work can be useful for applications such as novel designs
    of high-dimensional quantum key distribution and quantum information processing
    protocols. In addition, our method can be readily applied for controlling other
    degrees of freedom of light in the SPDC process, such as spectral and temporal
    properties, and may even be used in condensed-matter systems having a similar
    interaction Hamiltonian.
article_processing_charge: No
article_type: original
author:
- first_name: Eyal
  full_name: Rozenberg, Eyal
  last_name: Rozenberg
- first_name: Aviv
  full_name: Karnieli, Aviv
  last_name: Karnieli
- first_name: Ofir
  full_name: Yesharim, Ofir
  last_name: Yesharim
- first_name: Joshua
  full_name: Foley-Comer, Joshua
  last_name: Foley-Comer
- first_name: Sivan
  full_name: Trajtenberg-Mills, Sivan
  last_name: Trajtenberg-Mills
- first_name: Daniel
  full_name: Freedman, Daniel
  last_name: Freedman
- first_name: Alexander
  full_name: Bronstein, Alexander
  id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6
  last_name: Bronstein
  orcid: 0000-0001-9699-8730
- first_name: Ady
  full_name: Arie, Ady
  last_name: Arie
citation:
  ama: Rozenberg E, Karnieli A, Yesharim O, et al. Inverse design of spontaneous parametric
    downconversion for generation of high-dimensional qudits. <i>Optica</i>. 2022;9(6):602-615.
    doi:<a href="https://doi.org/10.1364/optica.451115">10.1364/optica.451115</a>
  apa: Rozenberg, E., Karnieli, A., Yesharim, O., Foley-Comer, J., Trajtenberg-Mills,
    S., Freedman, D., … Arie, A. (2022). Inverse design of spontaneous parametric
    downconversion for generation of high-dimensional qudits. <i>Optica</i>. Optica
    Publishing Group. <a href="https://doi.org/10.1364/optica.451115">https://doi.org/10.1364/optica.451115</a>
  chicago: Rozenberg, Eyal, Aviv Karnieli, Ofir Yesharim, Joshua Foley-Comer, Sivan
    Trajtenberg-Mills, Daniel Freedman, Alex M. Bronstein, and Ady Arie. “Inverse
    Design of Spontaneous Parametric Downconversion for Generation of High-Dimensional
    Qudits.” <i>Optica</i>. Optica Publishing Group, 2022. <a href="https://doi.org/10.1364/optica.451115">https://doi.org/10.1364/optica.451115</a>.
  ieee: E. Rozenberg <i>et al.</i>, “Inverse design of spontaneous parametric downconversion
    for generation of high-dimensional qudits,” <i>Optica</i>, vol. 9, no. 6. Optica
    Publishing Group, pp. 602–615, 2022.
  ista: Rozenberg E, Karnieli A, Yesharim O, Foley-Comer J, Trajtenberg-Mills S, Freedman
    D, Bronstein AM, Arie A. 2022. Inverse design of spontaneous parametric downconversion
    for generation of high-dimensional qudits. Optica. 9(6), 602–615.
  mla: Rozenberg, Eyal, et al. “Inverse Design of Spontaneous Parametric Downconversion
    for Generation of High-Dimensional Qudits.” <i>Optica</i>, vol. 9, no. 6, Optica
    Publishing Group, 2022, pp. 602–15, doi:<a href="https://doi.org/10.1364/optica.451115">10.1364/optica.451115</a>.
  short: E. Rozenberg, A. Karnieli, O. Yesharim, J. Foley-Comer, S. Trajtenberg-Mills,
    D. Freedman, A.M. Bronstein, A. Arie, Optica 9 (2022) 602–615.
date_created: 2024-10-08T12:54:43Z
date_published: 2022-06-06T00:00:00Z
date_updated: 2024-10-14T11:07:29Z
day: '06'
doi: 10.1364/optica.451115
extern: '1'
intvolume: '         9'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1364/OPTICA.451115
month: '06'
oa: 1
oa_version: Published Version
page: 602-615
publication: Optica
publication_identifier:
  issn:
  - 2334-2536
publication_status: published
publisher: Optica Publishing Group
quality_controlled: '1'
scopus_import: '1'
status: public
title: Inverse design of spontaneous parametric downconversion for generation of high-dimensional
  qudits
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2022'
...
---
_id: '18227'
abstract:
- lang: eng
  text: Existing cross-modal hashing methods ignore the informative multimodal joint
    information and cannot fully exploit the semantic labels. In this paper, we propose
    a deep fused two-step cross-modal hashing (DFTH) framework with multiple semantic
    supervision. In the first step, DFTH learns unified hash codes for instances by
    a fusion network. Semantic label and similarity reconstruction have been introduced
    to acquire binary codes that are informative, discriminative and semantic similarity
    preserving. In the second step, two modality-specific hash networks are learned
    under the supervision of common hash codes reconstruction, label reconstruction,
    and intra-modal and inter-modal semantic similarity reconstruction. The modality-specific
    hash networks can generate semantic preserving binary codes for out-of-sample
    queries. To deal with the vanishing gradients of binarization, continuous differentiable
    tanh is introduced to approximate the discrete sign function, making the networks
    able to back-propagate by automatic gradient computation. Extensive experiments
    on MIRFlickr25K and NUS-WIDE show the superiority of DFTH over state-of-the-art
    methods.
article_processing_charge: No
article_type: original
author:
- first_name: Peipei
  full_name: Kang, Peipei
  last_name: Kang
- first_name: Zehang
  full_name: Lin, Zehang
  last_name: Lin
- first_name: Zhenguo
  full_name: Yang, Zhenguo
  last_name: Yang
- first_name: Alexander
  full_name: Bronstein, Alexander
  id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6
  last_name: Bronstein
  orcid: 0000-0001-9699-8730
- first_name: Qing
  full_name: Li, Qing
  last_name: Li
- first_name: Wenyin
  full_name: Liu, Wenyin
  last_name: Liu
citation:
  ama: Kang P, Lin Z, Yang Z, Bronstein AM, Li Q, Liu W. Deep fused two-step cross-modal
    hashing with multiple semantic supervision. <i>Multimedia Tools and Applications</i>.
    2022;81(11):15653-15670. doi:<a href="https://doi.org/10.1007/s11042-022-12187-6">10.1007/s11042-022-12187-6</a>
  apa: Kang, P., Lin, Z., Yang, Z., Bronstein, A. M., Li, Q., &#38; Liu, W. (2022).
    Deep fused two-step cross-modal hashing with multiple semantic supervision. <i>Multimedia
    Tools and Applications</i>. Springer Nature. <a href="https://doi.org/10.1007/s11042-022-12187-6">https://doi.org/10.1007/s11042-022-12187-6</a>
  chicago: Kang, Peipei, Zehang Lin, Zhenguo Yang, Alex M. Bronstein, Qing Li, and
    Wenyin Liu. “Deep Fused Two-Step Cross-Modal Hashing with Multiple Semantic Supervision.”
    <i>Multimedia Tools and Applications</i>. Springer Nature, 2022. <a href="https://doi.org/10.1007/s11042-022-12187-6">https://doi.org/10.1007/s11042-022-12187-6</a>.
  ieee: P. Kang, Z. Lin, Z. Yang, A. M. Bronstein, Q. Li, and W. Liu, “Deep fused
    two-step cross-modal hashing with multiple semantic supervision,” <i>Multimedia
    Tools and Applications</i>, vol. 81, no. 11. Springer Nature, pp. 15653–15670,
    2022.
  ista: Kang P, Lin Z, Yang Z, Bronstein AM, Li Q, Liu W. 2022. Deep fused two-step
    cross-modal hashing with multiple semantic supervision. Multimedia Tools and Applications.
    81(11), 15653–15670.
  mla: Kang, Peipei, et al. “Deep Fused Two-Step Cross-Modal Hashing with Multiple
    Semantic Supervision.” <i>Multimedia Tools and Applications</i>, vol. 81, no.
    11, Springer Nature, 2022, pp. 15653–70, doi:<a href="https://doi.org/10.1007/s11042-022-12187-6">10.1007/s11042-022-12187-6</a>.
  short: P. Kang, Z. Lin, Z. Yang, A.M. Bronstein, Q. Li, W. Liu, Multimedia Tools
    and Applications 81 (2022) 15653–15670.
date_created: 2024-10-08T12:55:04Z
date_published: 2022-05-01T00:00:00Z
date_updated: 2024-10-14T11:10:00Z
day: '01'
doi: 10.1007/s11042-022-12187-6
extern: '1'
intvolume: '        81'
issue: '11'
language:
- iso: eng
month: '05'
oa_version: None
page: 15653-15670
publication: Multimedia Tools and Applications
publication_identifier:
  eissn:
  - 1573-7721
  issn:
  - 1380-7501
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Deep fused two-step cross-modal hashing with multiple semantic supervision
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 81
year: '2022'
...
---
_id: '18229'
abstract:
- lang: eng
  text: We present Self-Classifier – a novel self-supervised end-to-end classification
    learning approach. Self-Classifier learns labels and representations simultaneously
    in a single-stage end-to-end manner by optimizing for same-class prediction of
    two augmented views of the same sample. To guarantee non-degenerate solutions
    (i.e., solutions where all labels are assigned to the same class) we propose a
    mathematically motivated variant of the cross-entropy loss that has a uniform
    prior asserted on the predicted labels. In our theoretical analysis, we prove
    that degenerate solutions are not in the set of optimal solutions of our approach.
    Self-Classifier is simple to implement and scalable. Unlike other popular unsupervised
    classification and contrastive representation learning approaches, it does not
    require any form of pre-training, expectation-maximization, pseudo-labeling, external
    clustering, a second network, stop-gradient operation, or negative pairs. Despite
    its simplicity, our approach sets a new state of the art for unsupervised classification
    of ImageNet; and even achieves comparable to state-of-the-art results for unsupervised
    representation learning. Code is available at https://github.com/elad-amrani/self-classifier.
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Elad
  full_name: Amrani, Elad
  last_name: Amrani
- first_name: Leonid
  full_name: Karlinsky, Leonid
  last_name: Karlinsky
- first_name: Alexander
  full_name: Bronstein, Alexander
  id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6
  last_name: Bronstein
  orcid: 0000-0001-9699-8730
citation:
  ama: 'Amrani E, Karlinsky L, Bronstein AM. Self-supervised classification network.
    In: <i>17th European Conference on Computer Vision</i>. Vol 13691. Springer Nature;
    2022:116-132. doi:<a href="https://doi.org/10.1007/978-3-031-19821-2_7">10.1007/978-3-031-19821-2_7</a>'
  apa: 'Amrani, E., Karlinsky, L., &#38; Bronstein, A. M. (2022). Self-supervised
    classification network. In <i>17th European Conference on Computer Vision</i>
    (Vol. 13691, pp. 116–132). Tel Aviv, Israel: Springer Nature. <a href="https://doi.org/10.1007/978-3-031-19821-2_7">https://doi.org/10.1007/978-3-031-19821-2_7</a>'
  chicago: Amrani, Elad, Leonid Karlinsky, and Alex M. Bronstein. “Self-Supervised
    Classification Network.” In <i>17th European Conference on Computer Vision</i>,
    13691:116–32. Springer Nature, 2022. <a href="https://doi.org/10.1007/978-3-031-19821-2_7">https://doi.org/10.1007/978-3-031-19821-2_7</a>.
  ieee: E. Amrani, L. Karlinsky, and A. M. Bronstein, “Self-supervised classification
    network,” in <i>17th European Conference on Computer Vision</i>, Tel Aviv, Israel,
    2022, vol. 13691, pp. 116–132.
  ista: 'Amrani E, Karlinsky L, Bronstein AM. 2022. Self-supervised classification
    network. 17th European Conference on Computer Vision. ECCV: European Conference
    on Computer Vision, LNCS, vol. 13691, 116–132.'
  mla: Amrani, Elad, et al. “Self-Supervised Classification Network.” <i>17th European
    Conference on Computer Vision</i>, vol. 13691, Springer Nature, 2022, pp. 116–32,
    doi:<a href="https://doi.org/10.1007/978-3-031-19821-2_7">10.1007/978-3-031-19821-2_7</a>.
  short: E. Amrani, L. Karlinsky, A.M. Bronstein, in:, 17th European Conference on
    Computer Vision, Springer Nature, 2022, pp. 116–132.
conference:
  end_date: 2022-10-27
  location: Tel Aviv, Israel
  name: 'ECCV: European Conference on Computer Vision'
  start_date: 2022-10-23
date_created: 2024-10-08T12:55:44Z
date_published: 2022-10-23T00:00:00Z
date_updated: 2024-10-15T07:04:39Z
day: '23'
doi: 10.1007/978-3-031-19821-2_7
extern: '1'
external_id:
  arxiv:
  - '2103.10994'
intvolume: '     13691'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2103.10994
month: '10'
oa: 1
oa_version: None
page: 116-132
publication: 17th European Conference on Computer Vision
publication_identifier:
  eisbn:
  - '9783031198212'
  eissn:
  - 1611-3349
  isbn:
  - '9783031198205'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - relation: software
    url: https://github.com/elad-amrani/self-classifier
scopus_import: '1'
status: public
title: Self-supervised classification network
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13691
year: '2022'
...
---
_id: '18230'
abstract:
- lang: eng
  text: 'A variety of complex systems, including social and communication networks,
    financial markets, biology, and neuroscience are modeled using temporal graphs
    that contain a set of nodes and directed timestamped edges. Temporal motifs in
    temporal graphs are generalized from subgraph patterns in static graphs in that
    they also account for edge ordering and time duration, in addition to the graph
    structure. Mining temporal motifs is a fundamental problem used in several application
    domains. However, existing software frameworks offer suboptimal performance due
    to high algorithmic complexity and irregular memory accesses of temporal motif
    mining.This paper presents Mint—a novel accelerator architecture and a programming
    model for mining temporal motifs efficiently. We first divide this workload into
    three fundamental tasks: search, book-keeping, and backtracking. Based on this,
    we propose a task-centric programming model that enables decoupled, asynchronous
    execution. This model unlocks massive opportunities for parallelism, and allows
    storing task context information on-chip. To best utilize the proposed programming
    model, we design a domain-specific hardware accelerator using its data path and
    memory subsystem design to cater to the unique workload characteristics of temporal
    motif mining. To further improve performance, we propose a novel optimization
    called search index memoization that significantly reduces memory traffic. We
    comprehensively compare the performance of Mint with state-of-the-art temporal
    motif mining software frameworks (both approximate and exact) running on both
    CPU and GPU, and show 9×−2576× benefit in performance.'
article_processing_charge: No
author:
- first_name: Nishil
  full_name: Talati, Nishil
  last_name: Talati
- first_name: Haojie
  full_name: Ye, Haojie
  last_name: Ye
- first_name: Sanketh
  full_name: Vedula, Sanketh
  last_name: Vedula
- first_name: Kuan-Yu
  full_name: Chen, Kuan-Yu
  last_name: Chen
- first_name: Yuhan
  full_name: Chen, Yuhan
  last_name: Chen
- first_name: Daniel
  full_name: Liu, Daniel
  last_name: Liu
- first_name: Yichao
  full_name: Yuan, Yichao
  last_name: Yuan
- first_name: David
  full_name: Blaauw, David
  last_name: Blaauw
- first_name: Alexander
  full_name: Bronstein, Alexander
  id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6
  last_name: Bronstein
  orcid: 0000-0001-9699-8730
- first_name: Trevor
  full_name: Mudge, Trevor
  last_name: Mudge
- first_name: Ronald
  full_name: Dreslinski, Ronald
  last_name: Dreslinski
citation:
  ama: 'Talati N, Ye H, Vedula S, et al. Mint: An accelerator for mining temporal
    motifs. In: <i>55th IEEE/ACM International Symposium on Microarchitecture</i>.
    Institute of Electrical and Electronics Engineers; 2022. doi:<a href="https://doi.org/10.1109/micro56248.2022.00089">10.1109/micro56248.2022.00089</a>'
  apa: 'Talati, N., Ye, H., Vedula, S., Chen, K.-Y., Chen, Y., Liu, D., … Dreslinski,
    R. (2022). Mint: An accelerator for mining temporal motifs. In <i>55th IEEE/ACM
    International Symposium on Microarchitecture</i>. Chicago, IL, United States:
    Institute of Electrical and Electronics Engineers. <a href="https://doi.org/10.1109/micro56248.2022.00089">https://doi.org/10.1109/micro56248.2022.00089</a>'
  chicago: 'Talati, Nishil, Haojie Ye, Sanketh Vedula, Kuan-Yu Chen, Yuhan Chen, Daniel
    Liu, Yichao Yuan, et al. “Mint: An Accelerator for Mining Temporal Motifs.” In
    <i>55th IEEE/ACM International Symposium on Microarchitecture</i>. Institute of
    Electrical and Electronics Engineers, 2022. <a href="https://doi.org/10.1109/micro56248.2022.00089">https://doi.org/10.1109/micro56248.2022.00089</a>.'
  ieee: 'N. Talati <i>et al.</i>, “Mint: An accelerator for mining temporal motifs,”
    in <i>55th IEEE/ACM International Symposium on Microarchitecture</i>, Chicago,
    IL, United States, 2022.'
  ista: 'Talati N, Ye H, Vedula S, Chen K-Y, Chen Y, Liu D, Yuan Y, Blaauw D, Bronstein
    AM, Mudge T, Dreslinski R. 2022. Mint: An accelerator for mining temporal motifs.
    55th IEEE/ACM International Symposium on Microarchitecture. MICRO: Symposium on
    Microarchitecture.'
  mla: 'Talati, Nishil, et al. “Mint: An Accelerator for Mining Temporal Motifs.”
    <i>55th IEEE/ACM International Symposium on Microarchitecture</i>, Institute of
    Electrical and Electronics Engineers, 2022, doi:<a href="https://doi.org/10.1109/micro56248.2022.00089">10.1109/micro56248.2022.00089</a>.'
  short: N. Talati, H. Ye, S. Vedula, K.-Y. Chen, Y. Chen, D. Liu, Y. Yuan, D. Blaauw,
    A.M. Bronstein, T. Mudge, R. Dreslinski, in:, 55th IEEE/ACM International Symposium
    on Microarchitecture, Institute of Electrical and Electronics Engineers, 2022.
conference:
  end_date: 2022-10-05
  location: Chicago, IL, United States
  name: 'MICRO: Symposium on Microarchitecture'
  start_date: 2022-10-01
date_created: 2024-10-08T12:56:03Z
date_published: 2022-10-01T00:00:00Z
date_updated: 2024-10-15T07:14:02Z
day: '01'
doi: 10.1109/micro56248.2022.00089
extern: '1'
language:
- iso: eng
month: '10'
oa_version: None
publication: 55th IEEE/ACM International Symposium on Microarchitecture
publication_identifier:
  eisbn:
  - '9781665462723'
publication_status: published
publisher: Institute of Electrical and Electronics Engineers
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Mint: An accelerator for mining temporal motifs'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
OA_place: repository
OA_type: green
_id: '18231'
abstract:
- lang: eng
  text: 'The success of learning with noisy labels (LNL) methods relies heavily on
    the success of a warm-up stage where standard supervised training is performed
    using the full (noisy) training set. In this paper, we identify a "warm-up obstacle":
    the inability of standard warm-up stages to train high quality feature extractors
    and avert memorization of noisy labels. We propose "Contrast to Divide" (C2D),
    a simple framework that solves this problem by pre-training the feature extractor
    in a self-supervised fashion. Using self-supervised pre-training boosts the performance
    of existing LNL approaches by drastically reducing the warm-up stage''s susceptibility
    to noise level, shortening its duration, and improving extracted feature quality.
    C2D works out of the box with existing methods and demonstrates markedly improved
    performance, especially in the high noise regime, where we get a boost of more
    than 27% for CIFAR-100 with 90% noise over the previous state of the art. In real-life
    noise settings, C2D trained on mini-WebVision outperforms previous works both
    in WebVision and ImageNet validation sets by 3% top-1 accuracy. We perform an
    in-depth analysis of the framework, including investigating the performance of
    different pre-training approaches and estimating the effective upper bound of
    the LNL performance with semi-supervised learning. Code for reproducing our experiments
    is available at https://github.com/ContrastToDivide/C2D.'
article_processing_charge: No
arxiv: 1
author:
- first_name: Evgenii
  full_name: Zheltonozhskii, Evgenii
  last_name: Zheltonozhskii
- first_name: Chaim
  full_name: Baskin, Chaim
  last_name: Baskin
- first_name: Avi
  full_name: Mendelson, Avi
  last_name: Mendelson
- first_name: Alexander
  full_name: Bronstein, Alexander
  id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6
  last_name: Bronstein
  orcid: 0000-0001-9699-8730
- first_name: Or
  full_name: Litany, Or
  last_name: Litany
citation:
  ama: 'Zheltonozhskii E, Baskin C, Mendelson A, Bronstein AM, Litany O. Contrast
    to divide: Self-supervised pre-training for learning with noisy labels. In: <i>IEEE/CVF
    Winter Conference on Applications of Computer Vision</i>. Institute of Electrical
    and Electronics Engineers; 2022:387-397. doi:<a href="https://doi.org/10.1109/wacv51458.2022.00046">10.1109/wacv51458.2022.00046</a>'
  apa: 'Zheltonozhskii, E., Baskin, C., Mendelson, A., Bronstein, A. M., &#38; Litany,
    O. (2022). Contrast to divide: Self-supervised pre-training for learning with
    noisy labels. In <i>IEEE/CVF Winter Conference on Applications of Computer Vision</i>
    (pp. 387–397). Waikoloa, HI, United States: Institute of Electrical and Electronics
    Engineers. <a href="https://doi.org/10.1109/wacv51458.2022.00046">https://doi.org/10.1109/wacv51458.2022.00046</a>'
  chicago: 'Zheltonozhskii, Evgenii, Chaim Baskin, Avi Mendelson, Alex M. Bronstein,
    and Or Litany. “Contrast to Divide: Self-Supervised Pre-Training for Learning
    with Noisy Labels.” In <i>IEEE/CVF Winter Conference on Applications of Computer
    Vision</i>, 387–97. Institute of Electrical and Electronics Engineers, 2022. <a
    href="https://doi.org/10.1109/wacv51458.2022.00046">https://doi.org/10.1109/wacv51458.2022.00046</a>.'
  ieee: 'E. Zheltonozhskii, C. Baskin, A. Mendelson, A. M. Bronstein, and O. Litany,
    “Contrast to divide: Self-supervised pre-training for learning with noisy labels,”
    in <i>IEEE/CVF Winter Conference on Applications of Computer Vision</i>, Waikoloa,
    HI, United States, 2022, pp. 387–397.'
  ista: 'Zheltonozhskii E, Baskin C, Mendelson A, Bronstein AM, Litany O. 2022. Contrast
    to divide: Self-supervised pre-training for learning with noisy labels. IEEE/CVF
    Winter Conference on Applications of Computer Vision. WACV: Winter Conference
    on Applications of Computer Vision, 387–397.'
  mla: 'Zheltonozhskii, Evgenii, et al. “Contrast to Divide: Self-Supervised Pre-Training
    for Learning with Noisy Labels.” <i>IEEE/CVF Winter Conference on Applications
    of Computer Vision</i>, Institute of Electrical and Electronics Engineers, 2022,
    pp. 387–97, doi:<a href="https://doi.org/10.1109/wacv51458.2022.00046">10.1109/wacv51458.2022.00046</a>.'
  short: E. Zheltonozhskii, C. Baskin, A. Mendelson, A.M. Bronstein, O. Litany, in:,
    IEEE/CVF Winter Conference on Applications of Computer Vision, Institute of Electrical
    and Electronics Engineers, 2022, pp. 387–397.
conference:
  end_date: 2022-01-08
  location: Waikoloa, HI, United States
  name: 'WACV: Winter Conference on Applications of Computer Vision'
  start_date: 2022-01-03
date_created: 2024-10-08T12:56:20Z
date_published: 2022-02-15T00:00:00Z
date_updated: 2024-10-15T07:27:12Z
day: '15'
doi: 10.1109/wacv51458.2022.00046
extern: '1'
external_id:
  arxiv:
  - '2103.13646'
language:
- iso: eng
month: '02'
oa_version: Preprint
page: 387-397
publication: IEEE/CVF Winter Conference on Applications of Computer Vision
publication_identifier:
  eisbn:
  - '9781665409155'
publication_status: published
publisher: Institute of Electrical and Electronics Engineers
quality_controlled: '1'
related_material:
  link:
  - relation: software
    url: https://github.com/ContrastToDivide/C2D
scopus_import: '1'
status: public
title: 'Contrast to divide: Self-supervised pre-training for learning with noisy labels'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '18232'
abstract:
- lang: eng
  text: Cross-modal retrieval aims to retrieve related items across different modalities,
    for example, using an image query to retrieve related text. The existing deep
    methods ignore both the intra-modal and inter-modal intra-class low-rank structures
    when fusing various modalities, which decreases the retrieval performance. In
    this paper, two deep models (denoted as ILCMR and Semi-ILCMR) based on intra-class
    low-rank regularization are proposed for supervised and semi-supervised cross-modal
    retrieval, respectively. Specifically, ILCMR integrates the image network and
    text network into a unified framework to learn a common feature space by imposing
    three regularization terms to fuse the cross-modal data. First, to align them
    in the label space, we utilize semantic consistency regularization to convert
    the data representations to probability distributions over the classes. Second,
    we introduce an intra-modal low-rank regularization, which encourages the intra-class
    samples that originate from the same space to be more relevant in the common feature
    space. Third, an inter-modal low-rank regularization is applied to reduce the
    cross-modal discrepancy. To enable the low-rank regularization to be optimized
    using automatic gradients during network back-propagation, we propose the rank-r
    approximation and specify the explicit gradients for theoretical completeness.
    In addition to the three regularization terms that rely on label information incorporated
    by ILCMR, we propose Semi-ILCMR in the semi-supervised regime, which introduces
    a low-rank constraint before projecting the general representations into the common
    feature space. Extensive experiments on four public cross-modal datasets demonstrate
    the superiority of ILCMR and Semi-ILCMR over other state-of-the-art methods.
article_processing_charge: No
article_type: original
author:
- first_name: Peipei
  full_name: Kang, Peipei
  last_name: Kang
- first_name: Zehang
  full_name: Lin, Zehang
  last_name: Lin
- first_name: Zhenguo
  full_name: Yang, Zhenguo
  last_name: Yang
- first_name: Xiaozhao
  full_name: Fang, Xiaozhao
  last_name: Fang
- first_name: Alexander
  full_name: Bronstein, Alexander
  id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6
  last_name: Bronstein
  orcid: 0000-0001-9699-8730
- first_name: Qing
  full_name: Li, Qing
  last_name: Li
- first_name: Wenyin
  full_name: Liu, Wenyin
  last_name: Liu
citation:
  ama: Kang P, Lin Z, Yang Z, et al. Intra-class low-rank regularization for supervised
    and semi-supervised cross-modal retrieval. <i>Applied Intelligence</i>. 2022;52:33-54.
    doi:<a href="https://doi.org/10.1007/s10489-021-02308-3">10.1007/s10489-021-02308-3</a>
  apa: Kang, P., Lin, Z., Yang, Z., Fang, X., Bronstein, A. M., Li, Q., &#38; Liu,
    W. (2022). Intra-class low-rank regularization for supervised and semi-supervised
    cross-modal retrieval. <i>Applied Intelligence</i>. Springer Nature. <a href="https://doi.org/10.1007/s10489-021-02308-3">https://doi.org/10.1007/s10489-021-02308-3</a>
  chicago: Kang, Peipei, Zehang Lin, Zhenguo Yang, Xiaozhao Fang, Alex M. Bronstein,
    Qing Li, and Wenyin Liu. “Intra-Class Low-Rank Regularization for Supervised and
    Semi-Supervised Cross-Modal Retrieval.” <i>Applied Intelligence</i>. Springer
    Nature, 2022. <a href="https://doi.org/10.1007/s10489-021-02308-3">https://doi.org/10.1007/s10489-021-02308-3</a>.
  ieee: P. Kang <i>et al.</i>, “Intra-class low-rank regularization for supervised
    and semi-supervised cross-modal retrieval,” <i>Applied Intelligence</i>, vol.
    52. Springer Nature, pp. 33–54, 2022.
  ista: Kang P, Lin Z, Yang Z, Fang X, Bronstein AM, Li Q, Liu W. 2022. Intra-class
    low-rank regularization for supervised and semi-supervised cross-modal retrieval.
    Applied Intelligence. 52, 33–54.
  mla: Kang, Peipei, et al. “Intra-Class Low-Rank Regularization for Supervised and
    Semi-Supervised Cross-Modal Retrieval.” <i>Applied Intelligence</i>, vol. 52,
    Springer Nature, 2022, pp. 33–54, doi:<a href="https://doi.org/10.1007/s10489-021-02308-3">10.1007/s10489-021-02308-3</a>.
  short: P. Kang, Z. Lin, Z. Yang, X. Fang, A.M. Bronstein, Q. Li, W. Liu, Applied
    Intelligence 52 (2022) 33–54.
date_created: 2024-10-08T12:56:38Z
date_published: 2022-01-01T00:00:00Z
date_updated: 2024-10-15T07:30:00Z
day: '01'
doi: 10.1007/s10489-021-02308-3
extern: '1'
intvolume: '        52'
language:
- iso: eng
month: '01'
oa_version: None
page: 33-54
publication: Applied Intelligence
publication_identifier:
  eissn:
  - 1573-7497
  issn:
  - 0924-669X
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Intra-class low-rank regularization for supervised and semi-supervised cross-modal
  retrieval
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 52
year: '2022'
...
---
_id: '18291'
article_processing_charge: No
author:
- first_name: Georgios
  full_name: Katsaros, Georgios
  id: 38DB5788-F248-11E8-B48F-1D18A9856A87
  last_name: Katsaros
  orcid: 0000-0001-8342-202X
- first_name: Daniel
  full_name: Jirovec, Daniel
  id: 4C473F58-F248-11E8-B48F-1D18A9856A87
  last_name: Jirovec
  orcid: 0000-0002-7197-4801
citation:
  ama: "Katsaros G, Jirovec D. Dynamics of Hole Singlet-Triplet Qubits with Large
    \U0001D454-Factor Differences. 2022. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:18291\">10.15479/AT:ISTA:18291</a>"
  apa: "Katsaros, G., &#38; Jirovec, D. (2022). Dynamics of Hole Singlet-Triplet Qubits
    with Large \U0001D454-Factor Differences. Institute of Science and Technology
    Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:18291\">https://doi.org/10.15479/AT:ISTA:18291</a>"
  chicago: "Katsaros, Georgios, and Daniel Jirovec. “Dynamics of Hole Singlet-Triplet
    Qubits with Large \U0001D454-Factor Differences.” Institute of Science and Technology
    Austria, 2022. <a href=\"https://doi.org/10.15479/AT:ISTA:18291\">https://doi.org/10.15479/AT:ISTA:18291</a>."
  ieee: "G. Katsaros and D. Jirovec, “Dynamics of Hole Singlet-Triplet Qubits with
    Large \U0001D454-Factor Differences.” Institute of Science and Technology Austria,
    2022."
  ista: "Katsaros G, Jirovec D. 2022. Dynamics of Hole Singlet-Triplet Qubits with
    Large \U0001D454-Factor Differences, Institute of Science and Technology Austria,
    <a href=\"https://doi.org/10.15479/AT:ISTA:18291\">10.15479/AT:ISTA:18291</a>."
  mla: "Katsaros, Georgios, and Daniel Jirovec. <i>Dynamics of Hole Singlet-Triplet
    Qubits with Large \U0001D454-Factor Differences</i>. Institute of Science and
    Technology Austria, 2022, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:18291\">10.15479/AT:ISTA:18291</a>."
  short: G. Katsaros, D. Jirovec, (2022).
corr_author: '1'
date_created: 2024-10-09T19:35:03Z
date_published: 2022-03-01T00:00:00Z
date_updated: 2025-04-15T07:15:24Z
day: '01'
department:
- _id: GeKa
doi: 10.15479/AT:ISTA:18291
file:
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  content_type: application/x-zip-compressed
  creator: gkatsaro
  date_created: 2024-10-09T19:31:35Z
  date_updated: 2024-10-09T19:31:35Z
  file_id: '18292'
  file_name: SOIPaper.zip
  file_size: 25566516
  relation: main_file
  success: 1
- access_level: open_access
  checksum: df077d2f4652afeb3bf100068e88aa48
  content_type: text/plain
  creator: gkatsaro
  date_created: 2024-10-14T18:11:45Z
  date_updated: 2024-10-14T18:11:45Z
  file_id: '18442'
  file_name: Readme.txt
  file_size: 6776
  relation: main_file
  success: 1
file_date_updated: 2024-10-14T18:11:45Z
has_accepted_license: '1'
license: https://creativecommons.org/licenses/by/4.0/
month: '03'
oa: 1
oa_version: None
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '10920'
    relation: research_paper
    status: public
status: public
title: "Dynamics of Hole Singlet-Triplet Qubits with Large \U0001D454-Factor Differences"
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: research_data
user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d
year: '2022'
...
---
OA_place: repository
OA_type: green
_id: '22043'
abstract:
- lang: eng
  text: We prove that multisoliton solutions of the Korteweg–de Vries equation are
    orbitally stable in H^-1(R). We introduce a variational characterization of multisolitons
    that remains meaningful at such low regularity and show that all optimizing sequences
    converge to the manifold of multisolitons. The proximity required at the initial
    time is uniform across the entire manifold of multisolitons; this had not been
    demonstrated previously, even in H^-1.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Rowan
  full_name: Killip, Rowan
  last_name: Killip
- first_name: Monica
  full_name: Visan, Monica
  id: 056daca0-b8d1-11f0-964f-f91054abf8ca
  last_name: Visan
citation:
  ama: Killip R, Vişan M. Orbital stability of KdV multisolitons in H-1. <i>Communications
    in Mathematical Physics</i>. 2022;389(3):1445-1473. doi:<a href="https://doi.org/10.1007/s00220-021-04280-y">10.1007/s00220-021-04280-y</a>
  apa: Killip, R., &#38; Vişan, M. (2022). Orbital stability of KdV multisolitons
    in H-1. <i>Communications in Mathematical Physics</i>. Springer Nature. <a href="https://doi.org/10.1007/s00220-021-04280-y">https://doi.org/10.1007/s00220-021-04280-y</a>
  chicago: Killip, Rowan, and Monica Vişan. “Orbital Stability of KdV Multisolitons
    in H-1.” <i>Communications in Mathematical Physics</i>. Springer Nature, 2022.
    <a href="https://doi.org/10.1007/s00220-021-04280-y">https://doi.org/10.1007/s00220-021-04280-y</a>.
  ieee: R. Killip and M. Vişan, “Orbital stability of KdV multisolitons in H-1,” <i>Communications
    in Mathematical Physics</i>, vol. 389, no. 3. Springer Nature, pp. 1445–1473,
    2022.
  ista: Killip R, Vişan M. 2022. Orbital stability of KdV multisolitons in H-1. Communications
    in Mathematical Physics. 389(3), 1445–1473.
  mla: Killip, Rowan, and Monica Vişan. “Orbital Stability of KdV Multisolitons in
    H-1.” <i>Communications in Mathematical Physics</i>, vol. 389, no. 3, Springer
    Nature, 2022, pp. 1445–73, doi:<a href="https://doi.org/10.1007/s00220-021-04280-y">10.1007/s00220-021-04280-y</a>.
  short: R. Killip, M. Vişan, Communications in Mathematical Physics 389 (2022) 1445–1473.
das_tickbox: '1'
date_created: 2026-06-19T07:46:39Z
date_published: 2022-02-01T00:00:00Z
date_updated: 2026-06-25T07:41:51Z
day: '01'
doi: 10.1007/s00220-021-04280-y
extern: '1'
external_id:
  arxiv:
  - '2009.06746'
intvolume: '       389'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2009.06746
month: '02'
oa: 1
oa_version: Preprint
page: 1445-1473
publication: Communications in Mathematical Physics
publication_identifier:
  eissn:
  - 1432-0916
  issn:
  - 0010-3616
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Orbital stability of KdV multisolitons in H-1
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 389
year: '2022'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '22126'
abstract:
- lang: eng
  text: During the second half of the 20th century, the Antarctic Peninsula region
    has undergone a long and sustained warming period, followed by a shorter but also
    sustained cooling period, and then a very recent return to warming conditions.
    All of these have profoundly impacted the glaciers peripheral to the Antarctic
    Peninsula. This paper focuses on the analysis of the surface mass balance monitoring
    of such glaciers by the glaciological method, complemented by the analysis of
    mass-balance estimates by geodetic methods, as well as frontal ablation estimates.
    We aim to summarize the current knowledge and outline the main challenges faced
    by investigating the mass balance of such peripheral glaciers and their current
    contribution to sea-level rise.
article_processing_charge: Yes
article_type: letter_note
author:
- first_name: Francisco
  full_name: Navarro, Francisco
  last_name: Navarro
- first_name: Cayetana
  full_name: Recio-Blitz, Cayetana
  last_name: Recio-Blitz
- first_name: Ricardo
  full_name: Rodríguez-Cielos, Ricardo
  last_name: Rodríguez-Cielos
- first_name: Jaime
  full_name: Otero, Jaime
  last_name: Otero
- first_name: Kaian
  full_name: Shahateet, Kaian
  last_name: Shahateet
- first_name: Eva
  full_name: De Andrés, Eva
  last_name: De Andrés
- first_name: María I.
  full_name: Corcuera, María I.
  last_name: Corcuera
- first_name: Unai
  full_name: Letamendia, Unai
  last_name: Letamendia
- first_name: José M
  full_name: Muñoz Hermosilla, José M
  id: e1037a6d-646e-11ef-b402-e0ed9ab0901e
  last_name: Muñoz Hermosilla
  orcid: 0000-0002-1990-8508
citation:
  ama: Navarro F, Recio-Blitz C, Rodríguez-Cielos R, et al. Surface mass balance monitoring
    of the peripheral glaciers of the Antarctic Peninsula in the context of regional
    climate change. <i>Annals of Glaciology</i>. 2022;63(87-89):101-106. doi:<a href="https://doi.org/10.1017/aog.2023.18">10.1017/aog.2023.18</a>
  apa: Navarro, F., Recio-Blitz, C., Rodríguez-Cielos, R., Otero, J., Shahateet, K.,
    De Andrés, E., … Muñoz Hermosilla, J. M. (2022). Surface mass balance monitoring
    of the peripheral glaciers of the Antarctic Peninsula in the context of regional
    climate change. <i>Annals of Glaciology</i>. Cambridge University Press. <a href="https://doi.org/10.1017/aog.2023.18">https://doi.org/10.1017/aog.2023.18</a>
  chicago: Navarro, Francisco, Cayetana Recio-Blitz, Ricardo Rodríguez-Cielos, Jaime
    Otero, Kaian Shahateet, Eva De Andrés, María I. Corcuera, Unai Letamendia, and
    José M Muñoz Hermosilla. “Surface Mass Balance Monitoring of the Peripheral Glaciers
    of the Antarctic Peninsula in the Context of Regional Climate Change.” <i>Annals
    of Glaciology</i>. Cambridge University Press, 2022. <a href="https://doi.org/10.1017/aog.2023.18">https://doi.org/10.1017/aog.2023.18</a>.
  ieee: F. Navarro <i>et al.</i>, “Surface mass balance monitoring of the peripheral
    glaciers of the Antarctic Peninsula in the context of regional climate change,”
    <i>Annals of Glaciology</i>, vol. 63, no. 87–89. Cambridge University Press, pp.
    101–106, 2022.
  ista: Navarro F, Recio-Blitz C, Rodríguez-Cielos R, Otero J, Shahateet K, De Andrés
    E, Corcuera MI, Letamendia U, Muñoz Hermosilla JM. 2022. Surface mass balance
    monitoring of the peripheral glaciers of the Antarctic Peninsula in the context
    of regional climate change. Annals of Glaciology. 63(87–89), 101–106.
  mla: Navarro, Francisco, et al. “Surface Mass Balance Monitoring of the Peripheral
    Glaciers of the Antarctic Peninsula in the Context of Regional Climate Change.”
    <i>Annals of Glaciology</i>, vol. 63, no. 87–89, Cambridge University Press, 2022,
    pp. 101–06, doi:<a href="https://doi.org/10.1017/aog.2023.18">10.1017/aog.2023.18</a>.
  short: F. Navarro, C. Recio-Blitz, R. Rodríguez-Cielos, J. Otero, K. Shahateet,
    E. De Andrés, M.I. Corcuera, U. Letamendia, J.M. Muñoz Hermosilla, Annals of Glaciology
    63 (2022) 101–106.
das_tickbox: '1'
date_created: 2026-06-22T12:19:18Z
date_published: 2022-09-01T00:00:00Z
date_updated: 2026-07-02T07:19:18Z
day: '01'
ddc:
- '550'
doi: 10.1017/aog.2023.18
extern: '1'
has_accepted_license: '1'
intvolume: '        63'
issue: 87-89
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1017/aog.2023.18
month: '09'
oa: 1
oa_version: Published Version
page: 101-106
publication: Annals of Glaciology
publication_identifier:
  eissn:
  - 1727-5644
  issn:
  - 0260-3055
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Surface mass balance monitoring of the peripheral glaciers of the Antarctic
  Peninsula in the context of regional climate change
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 63
year: '2022'
...
---
_id: '17063'
abstract:
- lang: eng
  text: This workshop continued a biannual series of workshops at Oberwolfach on dynamical
    systems that started with a meeting organized by Moser and Zehnder in 1981. Workshops
    in this series focus on new results and developments in dynamical systems and
    related areas of mathematics, with symplectic geometry playing an important role
    in recent years in connection with Hamiltonian dynamics. In this year special
    emphasis was placed on various kinds of spectra (in contact geometry, in Riemannian
    geometry, in dynamical systems and in symplectic topology) and their applications
    to dynamics.
article_processing_charge: No
article_type: original
author:
- first_name: Marie-Claude
  full_name: Arnaud, Marie-Claude
  last_name: Arnaud
- first_name: Helmut W.
  full_name: Hofer, Helmut W.
  last_name: Hofer
- first_name: Michael
  full_name: Hutchings, Michael
  last_name: Hutchings
- first_name: Vadim
  full_name: Kaloshin, Vadim
  id: FE553552-CDE8-11E9-B324-C0EBE5697425
  last_name: Kaloshin
  orcid: 0000-0002-6051-2628
citation:
  ama: Arnaud M-C, Hofer HW, Hutchings M, Kaloshin V. Dynamische Systeme. <i>Oberwolfach
    Reports</i>. 2022;18(3):1735-1803. doi:<a href="https://doi.org/10.4171/owr/2021/33">10.4171/owr/2021/33</a>
  apa: Arnaud, M.-C., Hofer, H. W., Hutchings, M., &#38; Kaloshin, V. (2022). Dynamische
    Systeme. <i>Oberwolfach Reports</i>. EMS Press. <a href="https://doi.org/10.4171/owr/2021/33">https://doi.org/10.4171/owr/2021/33</a>
  chicago: Arnaud, Marie-Claude, Helmut W. Hofer, Michael Hutchings, and Vadim Kaloshin.
    “Dynamische Systeme.” <i>Oberwolfach Reports</i>. EMS Press, 2022. <a href="https://doi.org/10.4171/owr/2021/33">https://doi.org/10.4171/owr/2021/33</a>.
  ieee: M.-C. Arnaud, H. W. Hofer, M. Hutchings, and V. Kaloshin, “Dynamische Systeme,”
    <i>Oberwolfach Reports</i>, vol. 18, no. 3. EMS Press, pp. 1735–1803, 2022.
  ista: Arnaud M-C, Hofer HW, Hutchings M, Kaloshin V. 2022. Dynamische Systeme. Oberwolfach
    Reports. 18(3), 1735–1803.
  mla: Arnaud, Marie-Claude, et al. “Dynamische Systeme.” <i>Oberwolfach Reports</i>,
    vol. 18, no. 3, EMS Press, 2022, pp. 1735–803, doi:<a href="https://doi.org/10.4171/owr/2021/33">10.4171/owr/2021/33</a>.
  short: M.-C. Arnaud, H.W. Hofer, M. Hutchings, V. Kaloshin, Oberwolfach Reports
    18 (2022) 1735–1803.
corr_author: '1'
das_tickbox: '1'
date_created: 2024-05-29T06:01:19Z
date_published: 2022-11-26T00:00:00Z
date_updated: 2026-07-06T11:52:32Z
day: '26'
ddc:
- '500'
department:
- _id: VaKa
doi: 10.4171/owr/2021/33
intvolume: '        18'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.doi.org/10.4171/OWR/2021/33
month: '11'
oa: 1
oa_version: Published Version
page: 1735-1803
publication: Oberwolfach Reports
publication_identifier:
  eissn:
  - 1660-8941
  issn:
  - 1660-8933
publication_status: published
publisher: EMS Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dynamische Systeme
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 18
year: '2022'
...
---
_id: '10042'
abstract:
- lang: eng
  text: SnSe has emerged as one of the most promising materials for thermoelectric
    energy conversion due to its extraordinary performance in its single-crystal form
    and its low-cost constituent elements. However, to achieve an economic impact,
    the polycrystalline counterpart needs to replicate the performance of the single
    crystal. Herein, we optimize the thermoelectric performance of polycrystalline
    SnSe produced by consolidating solution-processed and surface-engineered SnSe
    particles. In particular, the SnSe particles are coated with CdSe molecular complexes
    that crystallize during the sintering process, forming CdSe nanoparticles. The
    presence of CdSe nanoparticles inhibits SnSe grain growth during the consolidation
    step due to Zener pinning, yielding a material with a high density of grain boundaries.
    Moreover, the resulting SnSe–CdSe nanocomposites present a large number of defects
    at different length scales, which significantly reduce the thermal conductivity.
    The produced SnSe–CdSe nanocomposites exhibit thermoelectric figures of merit
    up to 2.2 at 786 K, which is among the highest reported for solution-processed
    SnSe.
acknowledgement: 'This work was financially supported by IST Austria and the Werner
  Siemens Foundation. Y.L. acknowledges funding from the European Union’s Horizon
  2020 research and innovation program under the Marie Sklodowska-Curie grant agreement
  No. 754411. S.L. and M.C. received funding from the European Union’s Horizon 2020
  research and innovation program under the Marie Skłodowska-Curie Grant Agreement
  No. 665385. J.D. acknowledges funding from the European Union’s Horizon 2020 research
  and innovation program under the Marie Sklodowska-Curie grant agreement no. 665919
  (P-SPHERE) cofunded by Severo Ochoa Programme. C.C. acknowledges funding from the
  FWF “Lise Meitner Fellowship” grant agreement M 2889-N. Y.Y. and O.C.-M. acknowledge
  the financial support from DFG within the project SFB 917: Nanoswitches. M.C.S.
  received funding from the European Union’s Horizon 2020 research and innovation
  programme under the Marie Skłodowska-Curie grant agreement No. 754510 (PROBIST)
  and the Severo Ochoa programme. J.D. received funding from the European Union’s
  Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie
  grant agreement No. 665919 (P-SPHERE) cofunded by Severo Ochoa Programme. The ICN2
  is funded by the CERCA Program/Generalitat de Catalunya and by the Severo Ochoa
  program of the Spanish Ministry of Economy, Industry, and Competitiveness (MINECO,
  grant no. SEV-2017-0706). ICN2 acknowledges funding from Generalitat de Catalunya
  2017 SGR 327 and the Spanish MINECO project NANOGEN (PID2020-116093RB-C43). This
  project received funding from the European Union’s Horizon 2020 research and innovation
  program under grant agreement No. 823717-ESTEEM3. The FIB sample preparation was
  conducted in the LMA-INA-Universidad de Zaragoza.'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Yu
  full_name: Liu, Yu
  id: 2A70014E-F248-11E8-B48F-1D18A9856A87
  last_name: Liu
  orcid: 0000-0001-7313-6740
- first_name: Mariano
  full_name: Calcabrini, Mariano
  id: 45D7531A-F248-11E8-B48F-1D18A9856A87
  last_name: Calcabrini
  orcid: 0000-0003-4566-5877
- first_name: Yuan
  full_name: Yu, Yuan
  last_name: Yu
- first_name: Seungho
  full_name: Lee, Seungho
  id: BB243B88-D767-11E9-B658-BC13E6697425
  last_name: Lee
  orcid: 0000-0002-6962-8598
- first_name: Cheng
  full_name: Chang, Cheng
  id: 9E331C2E-9F27-11E9-AE48-5033E6697425
  last_name: Chang
  orcid: 0000-0002-9515-4277
- first_name: Jérémy
  full_name: David, Jérémy
  last_name: David
- first_name: Tanmoy
  full_name: Ghosh, Tanmoy
  id: a5fc9bc3-feff-11ea-93fe-e8015a3c7e9d
  last_name: Ghosh
- first_name: Maria Chiara
  full_name: Spadaro, Maria Chiara
  last_name: Spadaro
- first_name: Chenyang
  full_name: Xie, Chenyang
  last_name: Xie
- first_name: Oana
  full_name: Cojocaru-Mirédin, Oana
  last_name: Cojocaru-Mirédin
- first_name: Jordi
  full_name: Arbiol, Jordi
  last_name: Arbiol
- first_name: Maria
  full_name: Ibáñez, Maria
  id: 43C61214-F248-11E8-B48F-1D18A9856A87
  last_name: Ibáñez
  orcid: 0000-0001-5013-2843
citation:
  ama: Liu Y, Calcabrini M, Yu Y, et al. Defect engineering in solution-processed
    polycrystalline SnSe leads to high thermoelectric performance. <i>ACS Nano</i>.
    2022;16(1):78-88. doi:<a href="https://doi.org/10.1021/acsnano.1c06720">10.1021/acsnano.1c06720</a>
  apa: Liu, Y., Calcabrini, M., Yu, Y., Lee, S., Chang, C., David, J., … Ibáñez, M.
    (2022). Defect engineering in solution-processed polycrystalline SnSe leads to
    high thermoelectric performance. <i>ACS Nano</i>. American Chemical Society. <a
    href="https://doi.org/10.1021/acsnano.1c06720">https://doi.org/10.1021/acsnano.1c06720</a>
  chicago: Liu, Yu, Mariano Calcabrini, Yuan Yu, Seungho Lee, Cheng Chang, Jérémy
    David, Tanmoy Ghosh, et al. “Defect Engineering in Solution-Processed Polycrystalline
    SnSe Leads to High Thermoelectric Performance.” <i>ACS Nano</i>. American Chemical
    Society, 2022. <a href="https://doi.org/10.1021/acsnano.1c06720">https://doi.org/10.1021/acsnano.1c06720</a>.
  ieee: Y. Liu <i>et al.</i>, “Defect engineering in solution-processed polycrystalline
    SnSe leads to high thermoelectric performance,” <i>ACS Nano</i>, vol. 16, no.
    1. American Chemical Society, pp. 78–88, 2022.
  ista: Liu Y, Calcabrini M, Yu Y, Lee S, Chang C, David J, Ghosh T, Spadaro MC, Xie
    C, Cojocaru-Mirédin O, Arbiol J, Ibáñez M. 2022. Defect engineering in solution-processed
    polycrystalline SnSe leads to high thermoelectric performance. ACS Nano. 16(1),
    78–88.
  mla: Liu, Yu, et al. “Defect Engineering in Solution-Processed Polycrystalline SnSe
    Leads to High Thermoelectric Performance.” <i>ACS Nano</i>, vol. 16, no. 1, American
    Chemical Society, 2022, pp. 78–88, doi:<a href="https://doi.org/10.1021/acsnano.1c06720">10.1021/acsnano.1c06720</a>.
  short: Y. Liu, M. Calcabrini, Y. Yu, S. Lee, C. Chang, J. David, T. Ghosh, M.C.
    Spadaro, C. Xie, O. Cojocaru-Mirédin, J. Arbiol, M. Ibáñez, ACS Nano 16 (2022)
    78–88.
corr_author: '1'
das_tickbox: '1'
date_created: 2021-09-24T07:55:12Z
date_published: 2022-01-25T00:00:00Z
date_updated: 2026-07-06T12:16:06Z
day: '25'
ddc:
- '540'
department:
- _id: MaIb
doi: 10.1021/acsnano.1c06720
ec_funded: 1
external_id:
  isi:
  - '000767223400008'
  pmid:
  - '34549956'
file:
- access_level: open_access
  checksum: 74f9c1aa5f95c0b992a4328e8e0247b4
  content_type: application/pdf
  creator: cchlebak
  date_created: 2022-03-02T16:17:29Z
  date_updated: 2022-03-02T16:17:29Z
  file_id: '10808'
  file_name: 2022_ACSNano_Liu.pdf
  file_size: 9050764
  relation: main_file
  success: 1
file_date_updated: 2022-03-02T16:17:29Z
has_accepted_license: '1'
intvolume: '        16'
isi: 1
issue: '1'
keyword:
- tin selenide
- nanocomposite
- grain growth
- Zener pinning
- thermoelectricity
- annealing
- solution processing
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 78-88
pmid: 1
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
- _id: 9B8F7476-BA93-11EA-9121-9846C619BF3A
  name: 'HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of
    Semiconductors for Waste Heat Recovery'
- _id: 9B8804FC-BA93-11EA-9121-9846C619BF3A
  grant_number: M02889
  name: Bottom-up Engineering for Thermoelectric Applications
publication: ACS Nano
publication_identifier:
  eissn:
  - 1936-086X
  issn:
  - 1936-0851
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
related_material:
  record:
  - id: '12885'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Defect engineering in solution-processed polycrystalline SnSe leads to high
  thermoelectric performance
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2022'
...
---
_id: '10766'
abstract:
- lang: eng
  text: Tension of the actomyosin cell cortex plays a key role in determining cell–cell
    contact growth and size. The level of cortical tension outside of the cell–cell
    contact, when pulling at the contact edge, scales with the total size to which
    a cell–cell contact can grow [J.-L. Maître et al., Science 338, 253–256 (2012)].
    Here, we show in zebrafish primary germ-layer progenitor cells that this monotonic
    relationship only applies to a narrow range of cortical tension increase and that
    above a critical threshold, contact size inversely scales with cortical tension.
    This switch from cortical tension increasing to decreasing progenitor cell–cell
    contact size is caused by cortical tension promoting E-cadherin anchoring to the
    actomyosin cytoskeleton, thereby increasing clustering and stability of E-cadherin
    at the contact. After tension-mediated E-cadherin stabilization at the contact
    exceeds a critical threshold level, the rate by which the contact expands in response
    to pulling forces from the cortex sharply drops, leading to smaller contacts at
    physiologically relevant timescales of contact formation. Thus, the activity of
    cortical tension in expanding cell–cell contact size is limited by tension-stabilizing
    E-cadherin–actin complexes at the contact.
acknowledged_ssus:
- _id: Bio
- _id: EM-Fac
- _id: PreCl
acknowledgement: 'We thank Guillaume Salbreaux, Silvia Grigolon, Edouard Hannezo,
  and Vanessa Barone for discussions and comments on the manuscript and Shayan Shamipour
  and Daniel Capek for help with data analysis. We also thank the Imaging & Optics,
  Electron Microscopy, and Zebrafish Facility Scientific Service Units at the Institute
  of Science and Technology Austria (ISTA)Nasser Darwish-Miranda  for continuous support.
  We acknowledge Hitoshi Morita for the gift of VinculinB-GFP plasmid. This research
  was supported by an ISTA Fellow Marie-Curie Co-funding of regional, national, and
  international programmes Grant P_IST_EU01 (to J.S.), European Molecular Biology
  Organization Long-Term Fellowship Grant, ALTF reference number: 187-2013 (to M.S.),
  Schroedinger Fellowship J4332-B28 (to M.S.), and European Research Council Advanced
  Grant (MECSPEC; to C.-P.H.).'
article_number: e2122030119
article_processing_charge: No
article_type: original
author:
- first_name: Jana
  full_name: Slovakova, Jana
  id: 30F3F2F0-F248-11E8-B48F-1D18A9856A87
  last_name: Slovakova
- first_name: Mateusz K
  full_name: Sikora, Mateusz K
  id: 2F74BCDE-F248-11E8-B48F-1D18A9856A87
  last_name: Sikora
- first_name: Feyza N
  full_name: Arslan, Feyza N
  id: 49DA7910-F248-11E8-B48F-1D18A9856A87
  last_name: Arslan
  orcid: 0000-0001-5809-9566
- first_name: Silvia
  full_name: Caballero Mancebo, Silvia
  id: 2F1E1758-F248-11E8-B48F-1D18A9856A87
  last_name: Caballero Mancebo
  orcid: 0000-0002-5223-3346
- first_name: Gabriel
  full_name: Krens, Gabriel
  id: 2B819732-F248-11E8-B48F-1D18A9856A87
  last_name: Krens
  orcid: 0000-0003-4761-5996
- first_name: Walter
  full_name: Kaufmann, Walter
  id: 3F99E422-F248-11E8-B48F-1D18A9856A87
  last_name: Kaufmann
  orcid: 0000-0001-9735-5315
- first_name: Jack
  full_name: Merrin, Jack
  id: 4515C308-F248-11E8-B48F-1D18A9856A87
  last_name: Merrin
  orcid: 0000-0001-5145-4609
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Slovakova J, Sikora MK, Arslan FN, et al. Tension-dependent stabilization of
    E-cadherin limits cell-cell contact expansion in zebrafish germ-layer progenitor
    cells. <i>Proceedings of the National Academy of Sciences of the United States
    of America</i>. 2022;119(8). doi:<a href="https://doi.org/10.1073/pnas.2122030119">10.1073/pnas.2122030119</a>
  apa: Slovakova, J., Sikora, M. K., Arslan, F. N., Caballero Mancebo, S., Krens,
    G., Kaufmann, W., … Heisenberg, C.-P. J. (2022). Tension-dependent stabilization
    of E-cadherin limits cell-cell contact expansion in zebrafish germ-layer progenitor
    cells. <i>Proceedings of the National Academy of Sciences of the United States
    of America</i>. National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.2122030119">https://doi.org/10.1073/pnas.2122030119</a>
  chicago: Slovakova, Jana, Mateusz K Sikora, Feyza N Arslan, Silvia Caballero Mancebo,
    Gabriel Krens, Walter Kaufmann, Jack Merrin, and Carl-Philipp J Heisenberg. “Tension-Dependent
    Stabilization of E-Cadherin Limits Cell-Cell Contact Expansion in Zebrafish Germ-Layer
    Progenitor Cells.” <i>Proceedings of the National Academy of Sciences of the United
    States of America</i>. National Academy of Sciences, 2022. <a href="https://doi.org/10.1073/pnas.2122030119">https://doi.org/10.1073/pnas.2122030119</a>.
  ieee: J. Slovakova <i>et al.</i>, “Tension-dependent stabilization of E-cadherin
    limits cell-cell contact expansion in zebrafish germ-layer progenitor cells,”
    <i>Proceedings of the National Academy of Sciences of the United States of America</i>,
    vol. 119, no. 8. National Academy of Sciences, 2022.
  ista: Slovakova J, Sikora MK, Arslan FN, Caballero Mancebo S, Krens G, Kaufmann
    W, Merrin J, Heisenberg C-PJ. 2022. Tension-dependent stabilization of E-cadherin
    limits cell-cell contact expansion in zebrafish germ-layer progenitor cells. Proceedings
    of the National Academy of Sciences of the United States of America. 119(8), e2122030119.
  mla: Slovakova, Jana, et al. “Tension-Dependent Stabilization of E-Cadherin Limits
    Cell-Cell Contact Expansion in Zebrafish Germ-Layer Progenitor Cells.” <i>Proceedings
    of the National Academy of Sciences of the United States of America</i>, vol.
    119, no. 8, e2122030119, National Academy of Sciences, 2022, doi:<a href="https://doi.org/10.1073/pnas.2122030119">10.1073/pnas.2122030119</a>.
  short: J. Slovakova, M.K. Sikora, F.N. Arslan, S. Caballero Mancebo, G. Krens, W.
    Kaufmann, J. Merrin, C.-P.J. Heisenberg, Proceedings of the National Academy of
    Sciences of the United States of America 119 (2022).
corr_author: '1'
date_created: 2022-02-20T23:01:31Z
date_published: 2022-02-14T00:00:00Z
date_updated: 2026-07-06T12:45:39Z
day: '14'
ddc:
- '570'
department:
- _id: CaHe
- _id: EM-Fac
- _id: Bio
doi: 10.1073/pnas.2122030119
ec_funded: 1
external_id:
  isi:
  - '000766926900009'
  pmid:
  - '35165179'
file:
- access_level: open_access
  checksum: d49f83c3580613966f71768ddb9a55a5
  content_type: application/pdf
  creator: dernst
  date_created: 2022-02-21T08:45:11Z
  date_updated: 2022-02-21T08:45:11Z
  file_id: '10780'
  file_name: 2022_PNAS_Slovakova.pdf
  file_size: 1609678
  relation: main_file
  success: 1
file_date_updated: 2022-02-21T08:45:11Z
has_accepted_license: '1'
intvolume: '       119'
isi: 1
issue: '8'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
- _id: 260F1432-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '742573'
  name: Interaction and feedback between cell mechanics and fate specification in
    vertebrate gastrulation
- _id: 2521E28E-B435-11E9-9278-68D0E5697425
  grant_number: 187-2013
  name: Modulation of adhesion function in cell-cell contact formation by cortical
    tension
publication: Proceedings of the National Academy of Sciences of the United States
  of America
publication_identifier:
  eissn:
  - 1091-6490
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
related_material:
  record:
  - id: '9750'
    relation: earlier_version
    status: public
scopus_import: '1'
status: public
title: Tension-dependent stabilization of E-cadherin limits cell-cell contact expansion
  in zebrafish germ-layer progenitor cells
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 119
year: '2022'
...
---
_id: '11843'
abstract:
- lang: eng
  text: A key attribute of persistent or recurring bacterial infections is the ability
    of the pathogen to evade the host’s immune response. Many Enterobacteriaceae express
    type 1 pili, a pre-adapted virulence trait, to invade host epithelial cells and
    establish persistent infections. However, the molecular mechanisms and strategies
    by which bacteria actively circumvent the immune response of the host remain poorly
    understood. Here, we identified CD14, the major co-receptor for lipopolysaccharide
    detection, on mouse dendritic cells (DCs) as a binding partner of FimH, the protein
    located at the tip of the type 1 pilus of Escherichia coli. The FimH amino acids
    involved in CD14 binding are highly conserved across pathogenic and non-pathogenic
    strains. Binding of the pathogenic strain CFT073 to CD14 reduced DC migration
    by overactivation of integrins and blunted expression of co-stimulatory molecules
    by overactivating the NFAT (nuclear factor of activated T-cells) pathway, both
    rate-limiting factors of T cell activation. This response was binary at the single-cell
    level, but averaged in larger populations exposed to both piliated and non-piliated
    pathogens, presumably via the exchange of immunomodulatory cytokines. While defining
    an active molecular mechanism of immune evasion by pathogens, the interaction
    between FimH and CD14 represents a potential target to interfere with persistent
    and recurrent infections, such as urinary tract infections or Crohn’s disease.
acknowledged_ssus:
- _id: Bio
- _id: PreCl
- _id: EM-Fac
acknowledgement: We thank Ulrich Dobrindt for providing UPEC strains CFT073, UTI89,
  and 536, Frank Assen, Vlad Gavra, Maximilian Götz, Bor Kavčič, Jonna Alanko, and
  Eva Kiermaier for help with experiments and Robert Hauschild, Julian Stopp, and
  Saren Tasciyan for help with data analysis. We thank the IST Austria Scientific
  Service Units, especially the Bioimaging facility, the Preclinical facility and
  the Electron microscopy facility for technical support, Jakob Wallner and all members
  of the Guet and Sixt lab for fruitful discussions and Daria Siekhaus for critically
  reading the manuscript. This work was supported by grants from the Austrian Research
  Promotion Agency (FEMtech 868984) to IG, the European Research Council (CoG 724373),
  and the Austrian Science Fund (FWF P29911) to MS.
article_number: e78995
article_processing_charge: Yes
article_type: original
author:
- first_name: Kathrin
  full_name: Tomasek, Kathrin
  id: 3AEC8556-F248-11E8-B48F-1D18A9856A87
  last_name: Tomasek
  orcid: 0000-0003-3768-877X
- first_name: Alexander F
  full_name: Leithner, Alexander F
  id: 3B1B77E4-F248-11E8-B48F-1D18A9856A87
  last_name: Leithner
  orcid: 0000-0002-1073-744X
- first_name: Ivana
  full_name: Glatzová, Ivana
  id: 727b3c7d-4939-11ec-89b3-b9b0750ab74d
  last_name: Glatzová
- first_name: Michael S.
  full_name: Lukesch, Michael S.
  last_name: Lukesch
- first_name: Calin C
  full_name: Guet, Calin C
  id: 47F8433E-F248-11E8-B48F-1D18A9856A87
  last_name: Guet
  orcid: 0000-0001-6220-2052
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
citation:
  ama: Tomasek K, Leithner AF, Glatzová I, Lukesch MS, Guet CC, Sixt MK. Type 1 piliated
    uropathogenic Escherichia coli hijack the host immune response by binding to CD14.
    <i>eLife</i>. 2022;11. doi:<a href="https://doi.org/10.7554/eLife.78995">10.7554/eLife.78995</a>
  apa: Tomasek, K., Leithner, A. F., Glatzová, I., Lukesch, M. S., Guet, C. C., &#38;
    Sixt, M. K. (2022). Type 1 piliated uropathogenic Escherichia coli hijack the
    host immune response by binding to CD14. <i>ELife</i>. eLife Sciences Publications.
    <a href="https://doi.org/10.7554/eLife.78995">https://doi.org/10.7554/eLife.78995</a>
  chicago: Tomasek, Kathrin, Alexander F Leithner, Ivana Glatzová, Michael S. Lukesch,
    Calin C Guet, and Michael K Sixt. “Type 1 Piliated Uropathogenic Escherichia Coli
    Hijack the Host Immune Response by Binding to CD14.” <i>ELife</i>. eLife Sciences
    Publications, 2022. <a href="https://doi.org/10.7554/eLife.78995">https://doi.org/10.7554/eLife.78995</a>.
  ieee: K. Tomasek, A. F. Leithner, I. Glatzová, M. S. Lukesch, C. C. Guet, and M.
    K. Sixt, “Type 1 piliated uropathogenic Escherichia coli hijack the host immune
    response by binding to CD14,” <i>eLife</i>, vol. 11. eLife Sciences Publications,
    2022.
  ista: Tomasek K, Leithner AF, Glatzová I, Lukesch MS, Guet CC, Sixt MK. 2022. Type
    1 piliated uropathogenic Escherichia coli hijack the host immune response by binding
    to CD14. eLife. 11, e78995.
  mla: Tomasek, Kathrin, et al. “Type 1 Piliated Uropathogenic Escherichia Coli Hijack
    the Host Immune Response by Binding to CD14.” <i>ELife</i>, vol. 11, e78995, eLife
    Sciences Publications, 2022, doi:<a href="https://doi.org/10.7554/eLife.78995">10.7554/eLife.78995</a>.
  short: K. Tomasek, A.F. Leithner, I. Glatzová, M.S. Lukesch, C.C. Guet, M.K. Sixt,
    ELife 11 (2022).
corr_author: '1'
date_created: 2022-08-14T22:01:46Z
date_published: 2022-07-26T00:00:00Z
date_updated: 2026-07-06T12:48:19Z
day: '26'
ddc:
- '570'
department:
- _id: MiSi
- _id: CaGu
doi: 10.7554/eLife.78995
ec_funded: 1
external_id:
  isi:
  - '000838410200001'
  pmid:
  - '35881547'
file:
- access_level: open_access
  checksum: 002a3c7c7ea5caa9af9cfbea308f6ea4
  content_type: application/pdf
  creator: cchlebak
  date_created: 2022-08-16T08:57:37Z
  date_updated: 2022-08-16T08:57:37Z
  file_id: '11861'
  file_name: 2022_eLife_Tomasek.pdf
  file_size: 2057577
  relation: main_file
  success: 1
file_date_updated: 2022-08-16T08:57:37Z
has_accepted_license: '1'
intvolume: '        11'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 25FE9508-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '724373'
  name: Cellular Navigation Along Spatial Gradients
- _id: 26018E70-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P29911
  name: Mechanical adaptation of lamellipodial actin
publication: eLife
publication_identifier:
  eissn:
  - 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
related_material:
  record:
  - id: '10316'
    relation: earlier_version
    status: public
scopus_import: '1'
status: public
title: Type 1 piliated uropathogenic Escherichia coli hijack the host immune response
  by binding to CD14
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2022'
...
