---
_id: '12081'
abstract:
- lang: eng
text: 'Selection accumulates information in the genome—it guides stochastically
evolving populations toward states (genotype frequencies) that would be unlikely
under neutrality. This can be quantified as the Kullback–Leibler (KL) divergence
between the actual distribution of genotype frequencies and the corresponding
neutral distribution. First, we show that this population-level information sets
an upper bound on the information at the level of genotype and phenotype, limiting
how precisely they can be specified by selection. Next, we study how the accumulation
and maintenance of information is limited by the cost of selection, measured as
the genetic load or the relative fitness variance, both of which we connect to
the control-theoretic KL cost of control. The information accumulation rate is
upper bounded by the population size times the cost of selection. This bound is
very general, and applies across models (Wright–Fisher, Moran, diffusion) and
to arbitrary forms of selection, mutation, and recombination. Finally, the cost
of maintaining information depends on how it is encoded: Specifying a single allele
out of two is expensive, but one bit encoded among many weakly specified loci
(as in a polygenic trait) is cheap.'
acknowledgement: We thank Ksenia Khudiakova, Wiktor Młynarski, Sean Stankowski, and
two anonymous reviewers for discussions and comments on the manuscript. G.T. and
M.H. acknowledge funding from the Human Frontier Science Program Grant RGP0032/2018.
N.B. acknowledges funding from ERC Grant 250152 “Information and Evolution.”
article_number: e2123152119
article_processing_charge: No
article_type: original
author:
- first_name: Michal
full_name: Hledik, Michal
id: 4171253A-F248-11E8-B48F-1D18A9856A87
last_name: Hledik
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: '1'
citation:
ama: Hledik M, Barton NH, Tkačik G. Accumulation and maintenance of information
in evolution. Proceedings of the National Academy of Sciences of the United
States of America. 2022;119(36). doi:10.1073/pnas.2123152119
apa: Hledik, M., Barton, N. H., & Tkačik, G. (2022). Accumulation and maintenance
of information in evolution. Proceedings of the National Academy of Sciences
of the United States of America. National Academy of Sciences. https://doi.org/10.1073/pnas.2123152119
chicago: Hledik, Michal, Nicholas H Barton, and Gašper Tkačik. “Accumulation and
Maintenance of Information in Evolution.” Proceedings of the National Academy
of Sciences of the United States of America. National Academy of Sciences,
2022. https://doi.org/10.1073/pnas.2123152119.
ieee: M. Hledik, N. H. Barton, and G. Tkačik, “Accumulation and maintenance of information
in evolution,” Proceedings of the National Academy of Sciences of the United
States of America, vol. 119, no. 36. National Academy of Sciences, 2022.
ista: Hledik M, Barton NH, Tkačik G. 2022. Accumulation and maintenance of information
in evolution. Proceedings of the National Academy of Sciences of the United States
of America. 119(36), e2123152119.
mla: Hledik, Michal, et al. “Accumulation and Maintenance of Information in Evolution.”
Proceedings of the National Academy of Sciences of the United States of America,
vol. 119, no. 36, e2123152119, National Academy of Sciences, 2022, doi:10.1073/pnas.2123152119.
short: M. Hledik, N.H. Barton, G. Tkačik, Proceedings of the National Academy of
Sciences of the United States of America 119 (2022).
corr_author: '1'
date_created: 2022-09-11T22:01:55Z
date_published: 2022-08-29T00:00:00Z
date_updated: 2026-10-02T11:40:30Z
day: '29'
ddc:
- '570'
department:
- _id: NiBa
- _id: GaTk
doi: 10.1073/pnas.2123152119
ec_funded: 1
external_id:
isi:
- '000889278400014'
pmid:
- '36037343'
file:
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checksum: 6dec51f6567da9039982a571508a8e4d
content_type: application/pdf
creator: dernst
date_created: 2022-09-12T08:08:12Z
date_updated: 2022-09-12T08:08:12Z
file_id: '12091'
file_name: 2022_PNAS_Hledik.pdf
file_size: 2165752
relation: main_file
success: 1
file_date_updated: 2022-09-12T08:08:12Z
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has_accepted_license: '1'
intvolume: ' 119'
isi: 1
issue: '36'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '250152'
name: Limits to selection in biology and in evolutionary computation
- _id: 2665AAFE-B435-11E9-9278-68D0E5697425
grant_number: RGP0034/2018
name: Can evolution minimize spurious signaling crosstalk to reach optimal performance?
publication: Proceedings of the National Academy of Sciences of the United States
of America
publication_identifier:
eissn:
- 1091-6490
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
related_material:
record:
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relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Accumulation and maintenance of information in evolution
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 119
year: '2022'
...
---
_id: '11438'
abstract:
- lang: eng
text: Lasers with well-controlled relative frequencies are indispensable for many
applications in science and technology. We present a frequency-offset locking
method for lasers based on beat-frequency discrimination utilizing hybrid electronic
LC filters. The method is specifically designed for decoupling the tightness of
the lock from the broadness of its capture range. The presented demonstration
locks two free-running diode lasers at 780 nm with a 5.5-GHz offset. It displays
an offset frequency instability below 55 Hz for time scales in excess of 1000
s and a minimum of 12 Hz at 10-s averaging. The performance is complemented with
a 190-MHz lock-capture range, a tuning range of up to 1 GHz, and a frequency ramp
agility of 200kHz/μs.
acknowledgement: This work was supported by IST Austria. The authors thank Yueheng
Shi for technical contributions.
article_number: '054031'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Vyacheslav
full_name: Li, Vyacheslav
id: 3A4FAA92-F248-11E8-B48F-1D18A9856A87
last_name: Li
- first_name: Fritz R
full_name: Diorico, Fritz R
id: 2E054C4C-F248-11E8-B48F-1D18A9856A87
last_name: Diorico
orcid: 0000-0002-4947-8924
- first_name: Onur
full_name: Hosten, Onur
id: 4C02D85E-F248-11E8-B48F-1D18A9856A87
last_name: Hosten
orcid: 0000-0002-2031-204X
citation:
ama: Li V, Diorico FR, Hosten O. Laser frequency-offset locking at 10-Hz-level instability
using hybrid electronic filters. Physical Review Applied. 2022;17(5). doi:10.1103/physrevapplied.17.054031
apa: Li, V., Diorico, F. R., & Hosten, O. (2022). Laser frequency-offset locking
at 10-Hz-level instability using hybrid electronic filters. Physical Review
Applied. American Physical Society. https://doi.org/10.1103/physrevapplied.17.054031
chicago: Li, Vyacheslav, Fritz R Diorico, and Onur Hosten. “Laser Frequency-Offset
Locking at 10-Hz-Level Instability Using Hybrid Electronic Filters.” Physical
Review Applied. American Physical Society, 2022. https://doi.org/10.1103/physrevapplied.17.054031.
ieee: V. Li, F. R. Diorico, and O. Hosten, “Laser frequency-offset locking at 10-Hz-level
instability using hybrid electronic filters,” Physical Review Applied,
vol. 17, no. 5. American Physical Society, 2022.
ista: Li V, Diorico FR, Hosten O. 2022. Laser frequency-offset locking at 10-Hz-level
instability using hybrid electronic filters. Physical Review Applied. 17(5), 054031.
mla: Li, Vyacheslav, et al. “Laser Frequency-Offset Locking at 10-Hz-Level Instability
Using Hybrid Electronic Filters.” Physical Review Applied, vol. 17, no.
5, 054031, American Physical Society, 2022, doi:10.1103/physrevapplied.17.054031.
short: V. Li, F.R. Diorico, O. Hosten, Physical Review Applied 17 (2022).
corr_author: '1'
das_tickbox: '0'
date_created: 2022-06-07T08:07:59Z
date_published: 2022-05-19T00:00:00Z
date_updated: 2026-10-02T11:41:41Z
day: '19'
department:
- _id: GradSch
- _id: OnHo
doi: 10.1103/physrevapplied.17.054031
external_id:
arxiv:
- '2111.13194'
isi:
- '000880670300001'
fulldoi: https://doi.org/10.1103/physrevapplied.17.054031
intvolume: ' 17'
isi: 1
issue: '5'
keyword:
- General Physics and Astronomy
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.48550/arXiv.2111.13194'
month: '05'
oa: 1
oa_version: Preprint
publication: Physical Review Applied
publication_identifier:
issn:
- 2331-7019
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
record:
- id: '17225'
relation: dissertation_contains
status: public
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Laser frequency-offset locking at 10-Hz-level instability using hybrid electronic
filters
type: journal_article
user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d
volume: 17
year: '2022'
...
---
_id: '11732'
abstract:
- lang: eng
text: We study the BCS energy gap Ξ in the high–density limit and derive an asymptotic
formula, which strongly depends on the strength of the interaction potential V
on the Fermi surface. In combination with the recent result by one of us (Math.
Phys. Anal. Geom. 25, 3, 2022) on the critical temperature Tc at high densities,
we prove the universality of the ratio of the energy gap and the critical temperature.
acknowledgement: "We are grateful to Robert Seiringer for helpful discussions and
many valuable comments\r\non an earlier version of the manuscript. J.H. acknowledges
partial financial support by the ERC Advanced Grant “RMTBeyond’ No. 101020331. Open
access funding provided by Institute of Science and Technology (IST Austria)"
article_number: '5'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Sven Joscha
full_name: Henheik, Sven Joscha
id: 31d731d7-d235-11ea-ad11-b50331c8d7fb
last_name: Henheik
orcid: 0000-0003-1106-327X
- first_name: Asbjørn Bækgaard
full_name: Lauritsen, Asbjørn Bækgaard
id: e1a2682f-dc8d-11ea-abe3-81da9ac728f1
last_name: Lauritsen
orcid: 0000-0003-4476-2288
citation:
ama: Henheik SJ, Lauritsen AB. The BCS energy gap at high density. Journal of
Statistical Physics. 2022;189. doi:10.1007/s10955-022-02965-9
apa: Henheik, S. J., & Lauritsen, A. B. (2022). The BCS energy gap at high density.
Journal of Statistical Physics. Springer Nature. https://doi.org/10.1007/s10955-022-02965-9
chicago: Henheik, Sven Joscha, and Asbjørn Bækgaard Lauritsen. “The BCS Energy Gap
at High Density.” Journal of Statistical Physics. Springer Nature, 2022.
https://doi.org/10.1007/s10955-022-02965-9.
ieee: S. J. Henheik and A. B. Lauritsen, “The BCS energy gap at high density,” Journal
of Statistical Physics, vol. 189. Springer Nature, 2022.
ista: Henheik SJ, Lauritsen AB. 2022. The BCS energy gap at high density. Journal
of Statistical Physics. 189, 5.
mla: Henheik, Sven Joscha, and Asbjørn Bækgaard Lauritsen. “The BCS Energy Gap at
High Density.” Journal of Statistical Physics, vol. 189, 5, Springer Nature,
2022, doi:10.1007/s10955-022-02965-9.
short: S.J. Henheik, A.B. Lauritsen, Journal of Statistical Physics 189 (2022).
corr_author: '1'
date_created: 2022-08-05T11:36:56Z
date_published: 2022-07-29T00:00:00Z
date_updated: 2026-10-02T11:43:00Z
day: '29'
ddc:
- '530'
department:
- _id: GradSch
- _id: LaEr
- _id: RoSe
doi: 10.1007/s10955-022-02965-9
ec_funded: 1
external_id:
isi:
- '000833007200002'
file:
- access_level: open_access
checksum: b398c4dbf65f71d417981d6e366427e9
content_type: application/pdf
creator: dernst
date_created: 2022-08-08T07:36:34Z
date_updated: 2022-08-08T07:36:34Z
file_id: '11746'
file_name: 2022_JourStatisticalPhysics_Henheik.pdf
file_size: 419563
relation: main_file
success: 1
file_date_updated: 2022-08-08T07:36:34Z
fulldoi: https://doi.org/10.1007/s10955-022-02965-9
has_accepted_license: '1'
intvolume: ' 189'
isi: 1
keyword:
- Mathematical Physics
- Statistical and Nonlinear Physics
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
call_identifier: H2020
grant_number: '101020331'
name: Random matrices beyond Wigner-Dyson-Mehta
publication: Journal of Statistical Physics
publication_identifier:
eissn:
- 1572-9613
issn:
- 0022-4715
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '19540'
relation: dissertation_contains
status: public
- id: '18135'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: The BCS energy gap at high density
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 189
year: '2022'
...
---
_id: '11660'
abstract:
- lang: eng
text: 'We characterize critical points of 1-dimensional maps paired in persistent
homology geometrically and this way get elementary proofs of theorems about the
symmetry of persistence diagrams and the variation of such maps. In particular,
we identify branching points and endpoints of networks as the sole source of asymmetry
and relate the cycle basis in persistent homology with a version of the stable
marriage problem. Our analysis provides the foundations of fast algorithms for
maintaining collections of interrelated sorted lists together with their persistence
diagrams. '
acknowledgement: 'This project has received funding from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme,
grant no. 788183, from the Wittgenstein Prize, Austrian Science Fund (FWF), grant
no. Z 342-N31, and from the DFG Collaborative Research Center TRR 109, ‘Discretization
in Geometry and Dynamics’, Austrian Science Fund (FWF), grant no. I 02979-N35. '
alternative_title:
- LIPIcs
article_processing_charge: No
author:
- first_name: Ranita
full_name: Biswas, Ranita
id: 3C2B033E-F248-11E8-B48F-1D18A9856A87
last_name: Biswas
orcid: 0000-0002-5372-7890
- first_name: Sebastiano
full_name: Cultrera di Montesano, Sebastiano
id: 34D2A09C-F248-11E8-B48F-1D18A9856A87
last_name: Cultrera di Montesano
orcid: 0000-0001-6249-0832
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Morteza
full_name: Saghafian, Morteza
last_name: Saghafian
citation:
ama: 'Biswas R, Cultrera di Montesano S, Edelsbrunner H, Saghafian M. A window to
the persistence of 1D maps. I: Geometric characterization of critical point pairs.
LIPIcs.'
apa: 'Biswas, R., Cultrera di Montesano, S., Edelsbrunner, H., & Saghafian,
M. (n.d.). A window to the persistence of 1D maps. I: Geometric characterization
of critical point pairs. LIPIcs. Schloss Dagstuhl - Leibniz-Zentrum für
Informatik.'
chicago: 'Biswas, Ranita, Sebastiano Cultrera di Montesano, Herbert Edelsbrunner,
and Morteza Saghafian. “A Window to the Persistence of 1D Maps. I: Geometric Characterization
of Critical Point Pairs.” LIPIcs. Schloss Dagstuhl - Leibniz-Zentrum für
Informatik, n.d.'
ieee: 'R. Biswas, S. Cultrera di Montesano, H. Edelsbrunner, and M. Saghafian, “A
window to the persistence of 1D maps. I: Geometric characterization of critical
point pairs,” LIPIcs. Schloss Dagstuhl - Leibniz-Zentrum für Informatik.'
ista: 'Biswas R, Cultrera di Montesano S, Edelsbrunner H, Saghafian M. A window
to the persistence of 1D maps. I: Geometric characterization of critical point
pairs. LIPIcs.'
mla: 'Biswas, Ranita, et al. “A Window to the Persistence of 1D Maps. I: Geometric
Characterization of Critical Point Pairs.” LIPIcs, Schloss Dagstuhl - Leibniz-Zentrum
für Informatik.'
short: R. Biswas, S. Cultrera di Montesano, H. Edelsbrunner, M. Saghafian, LIPIcs
(n.d.).
corr_author: '1'
date_created: 2022-07-27T09:31:15Z
date_published: 2022-07-25T00:00:00Z
date_updated: 2026-10-02T11:52:56Z
day: '25'
ddc:
- '510'
department:
- _id: GradSch
- _id: HeEd
ec_funded: 1
file:
- access_level: open_access
checksum: 95903f9d1649e8e437a967b6f2f64730
content_type: application/pdf
creator: scultrer
date_created: 2022-07-27T09:30:30Z
date_updated: 2022-07-27T09:30:30Z
file_id: '11661'
file_name: window 1.pdf
file_size: 564836
relation: main_file
file_date_updated: 2022-07-27T09:30:30Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Submitted Version
project:
- _id: 266A2E9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '788183'
name: Alpha Shape Theory Extended
- _id: 268116B8-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z00342
name: Mathematics, Computer Science
- _id: 2561EBF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I02979-N35
name: Persistence and stability of geometric complexes
publication: LIPIcs
publication_status: submitted
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
related_material:
record:
- id: '15094'
relation: dissertation_contains
status: public
- id: '13182'
relation: later_version
status: public
status: public
title: 'A window to the persistence of 1D maps. I: Geometric characterization of critical
point pairs'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '11658'
abstract:
- lang: eng
text: The depth of a cell in an arrangement of n (non-vertical) great-spheres in
Sd is the number of great-spheres that pass above the cell. We prove Euler-type
relations, which imply extensions of the classic Dehn–Sommerville relations for
convex polytopes to sublevel sets of the depth function, and we use the relations
to extend the expressions for the number of faces of neighborly polytopes to the
number of cells of levels in neighborly arrangements.
acknowledgement: This project has received funding from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme,
grant no. 788183, from the Wittgenstein Prize, Austrian Science Fund (FWF), grant
no. Z 342-N31, and from the DFG Collaborative Research Center TRR 109, ‘Discretization
in Geometry and Dynamics’, Austrian Science Fund (FWF), grant no. I 02979-N35.
article_processing_charge: No
author:
- first_name: Ranita
full_name: Biswas, Ranita
id: 3C2B033E-F248-11E8-B48F-1D18A9856A87
last_name: Biswas
orcid: 0000-0002-5372-7890
- first_name: Sebastiano
full_name: Cultrera di Montesano, Sebastiano
id: 34D2A09C-F248-11E8-B48F-1D18A9856A87
last_name: Cultrera di Montesano
orcid: 0000-0001-6249-0832
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Morteza
full_name: Saghafian, Morteza
id: f86f7148-b140-11ec-9577-95435b8df824
last_name: Saghafian
citation:
ama: 'Biswas R, Cultrera di Montesano S, Edelsbrunner H, Saghafian M. Depth in arrangements:
Dehn–Sommerville–Euler relations with applications. Leibniz International Proceedings
on Mathematics.'
apa: 'Biswas, R., Cultrera di Montesano, S., Edelsbrunner, H., & Saghafian,
M. (n.d.). Depth in arrangements: Dehn–Sommerville–Euler relations with applications.
Leibniz International Proceedings on Mathematics. Schloss Dagstuhl - Leibniz-Zentrum
für Informatik.'
chicago: 'Biswas, Ranita, Sebastiano Cultrera di Montesano, Herbert Edelsbrunner,
and Morteza Saghafian. “Depth in Arrangements: Dehn–Sommerville–Euler Relations
with Applications.” Leibniz International Proceedings on Mathematics. Schloss
Dagstuhl - Leibniz-Zentrum für Informatik, n.d.'
ieee: 'R. Biswas, S. Cultrera di Montesano, H. Edelsbrunner, and M. Saghafian, “Depth
in arrangements: Dehn–Sommerville–Euler relations with applications,” Leibniz
International Proceedings on Mathematics. Schloss Dagstuhl - Leibniz-Zentrum
für Informatik.'
ista: 'Biswas R, Cultrera di Montesano S, Edelsbrunner H, Saghafian M. Depth in
arrangements: Dehn–Sommerville–Euler relations with applications. Leibniz International
Proceedings on Mathematics.'
mla: 'Biswas, Ranita, et al. “Depth in Arrangements: Dehn–Sommerville–Euler Relations
with Applications.” Leibniz International Proceedings on Mathematics, Schloss
Dagstuhl - Leibniz-Zentrum für Informatik.'
short: R. Biswas, S. Cultrera di Montesano, H. Edelsbrunner, M. Saghafian, Leibniz
International Proceedings on Mathematics (n.d.).
corr_author: '1'
date_created: 2022-07-27T09:27:34Z
date_published: 2022-07-27T00:00:00Z
date_updated: 2026-10-02T11:55:11Z
day: '27'
ddc:
- '510'
department:
- _id: GradSch
- _id: HeEd
ec_funded: 1
file:
- access_level: open_access
checksum: b2f511e8b1cae5f1892b0cdec341acac
content_type: application/pdf
creator: scultrer
date_created: 2022-07-27T09:25:53Z
date_updated: 2022-07-27T09:25:53Z
file_id: '11659'
file_name: D-S-E.pdf
file_size: 639266
relation: main_file
file_date_updated: 2022-07-27T09:25:53Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Submitted Version
project:
- _id: 266A2E9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '788183'
name: Alpha Shape Theory Extended
- _id: 268116B8-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z00342
name: Mathematics, Computer Science
- _id: 2561EBF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I02979-N35
name: Persistence and stability of geometric complexes
publication: Leibniz International Proceedings on Mathematics
publication_status: draft
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
related_material:
record:
- id: '15094'
relation: dissertation_contains
status: public
- id: '15380'
relation: later_version
status: public
status: public
title: 'Depth in arrangements: Dehn–Sommerville–Euler relations with applications'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '12540'
abstract:
- lang: eng
text: We consider the problem of signal estimation in generalized linear models
defined via rotationally invariant design matrices. Since these matrices can have
an arbitrary spectral distribution, this model is well suited for capturing complex
correlation structures which often arise in applications. We propose a novel family
of approximate message passing (AMP) algorithms for signal estimation, and rigorously
characterize their performance in the high-dimensional limit via a state evolution
recursion. Our rotationally invariant AMP has complexity of the same order as
the existing AMP derived under the restrictive assumption of a Gaussian design;
our algorithm also recovers this existing AMP as a special case. Numerical results
showcase a performance close to Vector AMP (which is conjectured to be Bayes-optimal
in some settings), but obtained with a much lower complexity, as the proposed
algorithm does not require a computationally expensive singular value decomposition.
acknowledgement: The authors would like to thank the anonymous reviewers for their
helpful comments. KK and MM were partially supported by the 2019 Lopez-Loreta Prize.
article_number: '22'
article_processing_charge: No
author:
- first_name: Ramji
full_name: Venkataramanan, Ramji
last_name: Venkataramanan
- first_name: Kevin
full_name: Kögler, Kevin
id: 94ec913c-dc85-11ea-9058-e5051ab2428b
last_name: Kögler
- first_name: Marco
full_name: Mondelli, Marco
id: 27EB676C-8706-11E9-9510-7717E6697425
last_name: Mondelli
orcid: 0000-0002-3242-7020
citation:
ama: 'Venkataramanan R, Kögler K, Mondelli M. Estimation in rotationally invariant
generalized linear models via approximate message passing. In: Proceedings
of the 39th International Conference on Machine Learning. Vol 162. ML Research
Press; 2022.'
apa: 'Venkataramanan, R., Kögler, K., & Mondelli, M. (2022). Estimation in rotationally
invariant generalized linear models via approximate message passing. In Proceedings
of the 39th International Conference on Machine Learning (Vol. 162). Baltimore,
MD, United States: ML Research Press.'
chicago: Venkataramanan, Ramji, Kevin Kögler, and Marco Mondelli. “Estimation in
Rotationally Invariant Generalized Linear Models via Approximate Message Passing.”
In Proceedings of the 39th International Conference on Machine Learning,
Vol. 162. ML Research Press, 2022.
ieee: R. Venkataramanan, K. Kögler, and M. Mondelli, “Estimation in rotationally
invariant generalized linear models via approximate message passing,” in Proceedings
of the 39th International Conference on Machine Learning, Baltimore, MD, United
States, 2022, vol. 162.
ista: 'Venkataramanan R, Kögler K, Mondelli M. 2022. Estimation in rotationally
invariant generalized linear models via approximate message passing. Proceedings
of the 39th International Conference on Machine Learning. ICML: International
Conference on Machine Learning vol. 162, 22.'
mla: Venkataramanan, Ramji, et al. “Estimation in Rotationally Invariant Generalized
Linear Models via Approximate Message Passing.” Proceedings of the 39th International
Conference on Machine Learning, vol. 162, 22, ML Research Press, 2022.
short: R. Venkataramanan, K. Kögler, M. Mondelli, in:, Proceedings of the 39th International
Conference on Machine Learning, ML Research Press, 2022.
conference:
end_date: 2022-07-23
location: Baltimore, MD, United States
name: 'ICML: International Conference on Machine Learning'
start_date: 2022-07-17
corr_author: '1'
date_created: 2023-02-10T13:49:04Z
date_published: 2022-01-01T00:00:00Z
date_updated: 2026-10-12T13:04:49Z
ddc:
- '000'
department:
- _id: MaMo
file:
- access_level: open_access
checksum: 67436eb0a660789514cdf9db79e84683
content_type: application/pdf
creator: dernst
date_created: 2023-02-13T10:53:11Z
date_updated: 2023-02-13T10:53:11Z
file_id: '12547'
file_name: 2022_PMLR_Venkataramanan.pdf
file_size: 2341343
relation: main_file
success: 1
file_date_updated: 2023-02-13T10:53:11Z
has_accepted_license: '1'
intvolume: ' 162'
language:
- iso: eng
oa: 1
oa_version: Published Version
project:
- _id: 059876FA-7A3F-11EA-A408-12923DDC885E
name: Prix Lopez-Loretta 2019 - Marco Mondelli
publication: Proceedings of the 39th International Conference on Machine Learning
publication_status: published
publisher: ML Research Press
quality_controlled: '1'
related_material:
record:
- id: '23072'
relation: dissertation_contains
status: public
status: public
title: Estimation in rotationally invariant generalized linear models via approximate
message passing
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 162
year: '2022'
...
---
OA_place: publisher
OA_type: hybrid
_id: '23132'
abstract:
- lang: eng
text: Cellular regeneration in response to wounding is fundamental to maintain tissue
integrity. Various internal factors including hormones and transcription factors
mediate healing, but little is known about the role of external factors. To understand
how the environment affects regeneration, we investigated the effects of temperature
upon the horticulturally relevant process of plant grafting. We found that elevated
temperatures accelerated vascular regeneration in Arabidopsis thaliana and tomato
grafts. Leaves were crucial for this effect, as blocking auxin transport or mutating
PHYTOCHROME INTERACTING FACTOR 4 (PIF4) or YUCCA2/5/8/9 in the cotyledons abolished
the temperature enhancement. However, these perturbations did not affect grafting
at ambient temperatures, and temperature enhancement of callus formation and tissue
adhesion did not require PIF4, suggesting leaf-derived auxin specifically enhanced
vascular regeneration in response to elevated temperatures. We also found that
elevated temperatures accelerated the formation of inter-plant vascular connections
between the parasitic plant Phtheirospermum japonicum and host Arabidopsis, and
this effect required shoot-derived auxin from the parasite. Taken together, our
results identify a pathway whereby local temperature perception mediates long
distance auxin signaling to modify regeneration, grafting and parasitism.
article_number: dev200079
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Phanu T.
full_name: Serivichyaswat, Phanu T.
last_name: Serivichyaswat
- first_name: Kai
full_name: Bartusch, Kai
id: 0c51b9f5-90c8-11f1-b4ef-9ad5d3d9a34a
last_name: Bartusch
orcid: 0000-0003-2708-5545
- first_name: Martina
full_name: Leso, Martina
last_name: Leso
- first_name: Constance
full_name: Musseau, Constance
last_name: Musseau
- first_name: Akira
full_name: Iwase, Akira
last_name: Iwase
- first_name: Yu
full_name: Chen, Yu
last_name: Chen
- first_name: Keiko
full_name: Sugimoto, Keiko
last_name: Sugimoto
- first_name: Marcel
full_name: Quint, Marcel
last_name: Quint
- first_name: Charles W.
full_name: Melnyk, Charles W.
last_name: Melnyk
citation:
ama: Serivichyaswat PT, Bartusch K, Leso M, et al. High temperature perception in
leaves promotes vascular regeneration and graft formation in distant tissues.
Development. 2022;149(5). doi:10.1242/dev.200079
apa: Serivichyaswat, P. T., Bartusch, K., Leso, M., Musseau, C., Iwase, A., Chen,
Y., … Melnyk, C. W. (2022). High temperature perception in leaves promotes vascular
regeneration and graft formation in distant tissues. Development. The Company
of Biologists. https://doi.org/10.1242/dev.200079
chicago: Serivichyaswat, Phanu T., Kai Bartusch, Martina Leso, Constance Musseau,
Akira Iwase, Yu Chen, Keiko Sugimoto, Marcel Quint, and Charles W. Melnyk. “High
Temperature Perception in Leaves Promotes Vascular Regeneration and Graft Formation
in Distant Tissues.” Development. The Company of Biologists, 2022. https://doi.org/10.1242/dev.200079.
ieee: P. T. Serivichyaswat et al., “High temperature perception in leaves
promotes vascular regeneration and graft formation in distant tissues,” Development,
vol. 149, no. 5. The Company of Biologists, 2022.
ista: Serivichyaswat PT, Bartusch K, Leso M, Musseau C, Iwase A, Chen Y, Sugimoto
K, Quint M, Melnyk CW. 2022. High temperature perception in leaves promotes vascular
regeneration and graft formation in distant tissues. Development. 149(5), dev200079.
mla: Serivichyaswat, Phanu T., et al. “High Temperature Perception in Leaves Promotes
Vascular Regeneration and Graft Formation in Distant Tissues.” Development,
vol. 149, no. 5, dev200079, The Company of Biologists, 2022, doi:10.1242/dev.200079.
short: P.T. Serivichyaswat, K. Bartusch, M. Leso, C. Musseau, A. Iwase, Y. Chen,
K. Sugimoto, M. Quint, C.W. Melnyk, Development 149 (2022).
date_created: 2026-10-13T11:15:22Z
date_published: 2022-03-01T00:00:00Z
date_updated: 2026-10-14T12:22:27Z
day: '01'
ddc:
- '580'
doi: 10.1242/dev.200079
extern: '1'
external_id:
pmid:
- '35217857'
fulldoi: https://doi.org/10.1242/dev.200079
has_accepted_license: '1'
intvolume: ' 149'
issue: '5'
language:
- iso: eng
month: '03'
oa_version: Published Version
pmid: 1
publication: Development
publication_identifier:
eissn:
- 1477-9129
issn:
- 0950-1991
publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
scopus_import: '1'
status: public
title: High temperature perception in leaves promotes vascular regeneration and graft
formation in distant tissues
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 149
year: '2022'
...
---
_id: '14597'
abstract:
- lang: eng
text: "Phase-field models such as the Allen-Cahn equation may give rise to the formation
and evolution of geometric shapes, a phenomenon that may be analyzed rigorously
in suitable scaling regimes. In its sharp-interface limit, the vectorial Allen-Cahn
equation with a potential with N≥3 distinct minima has been conjectured to describe
the evolution of branched interfaces by multiphase mean curvature flow.\r\nIn
the present work, we give a rigorous proof for this statement in two and three
ambient dimensions and for a suitable class of potentials: As long as a strong
solution to multiphase mean curvature flow exists, solutions to the vectorial
Allen-Cahn equation with well-prepared initial data converge towards multiphase
mean curvature flow in the limit of vanishing interface width parameter ε↘0. We
even establish the rate of convergence O(ε1/2).\r\nOur approach is based on the
gradient flow structure of the Allen-Cahn equation and its limiting motion: Building
on the recent concept of \"gradient flow calibrations\" for multiphase mean curvature
flow, we introduce a notion of relative entropy for the vectorial Allen-Cahn equation
with multi-well potential. This enables us to overcome the limitations of other
approaches, e.g. avoiding the need for a stability analysis of the Allen-Cahn
operator or additional convergence hypotheses for the energy at positive times."
article_number: '2203.17143'
article_processing_charge: No
arxiv: 1
author:
- first_name: Julian L
full_name: Fischer, Julian L
id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
last_name: Fischer
orcid: 0000-0002-0479-558X
- first_name: Alice
full_name: Marveggio, Alice
id: 25647992-AA84-11E9-9D75-8427E6697425
last_name: Marveggio
citation:
ama: Fischer JL, Marveggio A. Quantitative convergence of the vectorial Allen-Cahn
equation towards multiphase mean curvature flow. arXiv. doi:10.48550/ARXIV.2203.17143
apa: Fischer, J. L., & Marveggio, A. (n.d.). Quantitative convergence of the
vectorial Allen-Cahn equation towards multiphase mean curvature flow. arXiv.
https://doi.org/10.48550/ARXIV.2203.17143
chicago: Fischer, Julian L, and Alice Marveggio. “Quantitative Convergence of the
Vectorial Allen-Cahn Equation towards Multiphase Mean Curvature Flow.” ArXiv,
n.d. https://doi.org/10.48550/ARXIV.2203.17143.
ieee: J. L. Fischer and A. Marveggio, “Quantitative convergence of the vectorial
Allen-Cahn equation towards multiphase mean curvature flow,” arXiv. .
ista: Fischer JL, Marveggio A. Quantitative convergence of the vectorial Allen-Cahn
equation towards multiphase mean curvature flow. arXiv, 2203.17143.
mla: Fischer, Julian L., and Alice Marveggio. “Quantitative Convergence of the Vectorial
Allen-Cahn Equation towards Multiphase Mean Curvature Flow.” ArXiv, 2203.17143,
doi:10.48550/ARXIV.2203.17143.
short: J.L. Fischer, A. Marveggio, ArXiv (n.d.).
corr_author: '1'
date_created: 2023-11-23T09:30:02Z
date_published: 2022-03-31T00:00:00Z
date_updated: 2026-10-15T09:49:35Z
day: '31'
department:
- _id: JuFi
doi: 10.48550/ARXIV.2203.17143
ec_funded: 1
external_id:
arxiv:
- '2203.17143'
fulldoi: https://doi.org/10.48550/ARXIV.2203.17143
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2203.17143
month: '03'
oa: 1
oa_version: Preprint
project:
- _id: 0aa76401-070f-11eb-9043-b5bb049fa26d
call_identifier: H2020
grant_number: '948819'
name: Bridging Scales in Random Materials
publication: arXiv
publication_status: draft
related_material:
record:
- id: '14587'
relation: dissertation_contains
status: public
- id: '17481'
relation: later_version
status: public
status: public
title: Quantitative convergence of the vectorial Allen-Cahn equation towards multiphase
mean curvature flow
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '11476'
abstract:
- lang: eng
text: "Messaging platforms like Signal are widely deployed and provide strong security
in an asynchronous setting. It is a challenging problem to construct a protocol
with similar security guarantees that can efficiently scale to large groups. A
major bottleneck are the frequent key rotations users need to perform to achieve
post compromise forward security.\r\n\r\nIn current proposals – most notably in
TreeKEM (which is part of the IETF’s Messaging Layer Security (MLS) protocol draft)
– for users in a group of size n to rotate their keys, they must each craft a
message of size log(n) to be broadcast to the group using an (untrusted) delivery
server.\r\n\r\nIn larger groups, having users sequentially rotate their keys requires
too much bandwidth (or takes too long), so variants allowing any T≤n users to
simultaneously rotate their keys in just 2 communication rounds have been suggested
(e.g. “Propose and Commit” by MLS). Unfortunately, 2-round concurrent updates
are either damaging or expensive (or both); i.e. they either result in future
operations being more costly (e.g. via “blanking” or “tainting”) or are costly
themselves requiring Ω(T) communication for each user [Bienstock et al., TCC’20].\r\n\r\nIn
this paper we propose CoCoA; a new scheme that allows for T concurrent updates
that are neither damaging nor costly. That is, they add no cost to future operations
yet they only require Ω(log2(n)) communication per user. To circumvent the [Bienstock
et al.] lower bound, CoCoA increases the number of rounds needed to complete all
updates from 2 up to (at most) log(n); though typically fewer rounds are needed.\r\n\r\nThe
key insight of our protocol is the following: in the (non-concurrent version of)
TreeKEM, a delivery server which gets T concurrent update requests will approve
one and reject the remaining T−1. In contrast, our server attempts to apply all
of them. If more than one user requests to rotate the same key during a round,
the server arbitrarily picks a winner. Surprisingly, we prove that regardless
of how the server chooses the winners, all previously compromised users will recover
after at most log(n) such update rounds.\r\n\r\nTo keep the communication complexity
low, CoCoA is a server-aided CGKA. That is, the delivery server no longer blindly
forwards packets, but instead actively computes individualized packets tailored
to each user. As the server is untrusted, this change requires us to develop new
mechanisms ensuring robustness of the protocol."
acknowledgement: We thank Marta Mularczyk and Yiannis Tselekounis for their very helpful
feedback on an earlier draft of this paper.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Joël
full_name: Alwen, Joël
last_name: Alwen
- first_name: Benedikt
full_name: Auerbach, Benedikt
id: D33D2B18-E445-11E9-ABB7-15F4E5697425
last_name: Auerbach
orcid: 0000-0002-7553-6606
- first_name: Miguel
full_name: Cueto Noval, Miguel
id: ffc563a3-f6e0-11ea-865d-e3cce03d17cc
last_name: Cueto Noval
orcid: 0000-0002-2505-4246
- first_name: Karen
full_name: Klein, Karen
id: 3E83A2F8-F248-11E8-B48F-1D18A9856A87
last_name: Klein
- first_name: Guillermo
full_name: Pascual Perez, Guillermo
id: 2D7ABD02-F248-11E8-B48F-1D18A9856A87
last_name: Pascual Perez
orcid: 0000-0001-8630-415X
- first_name: Krzysztof Z
full_name: Pietrzak, Krzysztof Z
id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
last_name: Pietrzak
orcid: 0000-0002-9139-1654
- first_name: Michael
full_name: Walter, Michael
last_name: Walter
citation:
ama: 'Alwen J, Auerbach B, Cueto Noval M, et al. CoCoA: Concurrent continuous group
key agreement. In: Advances in Cryptology – EUROCRYPT 2022. Vol 13276.
Cham: Springer Nature; 2022:815–844. doi:10.1007/978-3-031-07085-3_28'
apa: 'Alwen, J., Auerbach, B., Cueto Noval, M., Klein, K., Pascual Perez, G., Pietrzak,
K. Z., & Walter, M. (2022). CoCoA: Concurrent continuous group key agreement.
In Advances in Cryptology – EUROCRYPT 2022 (Vol. 13276, pp. 815–844). Cham:
Springer Nature. https://doi.org/10.1007/978-3-031-07085-3_28'
chicago: 'Alwen, Joël, Benedikt Auerbach, Miguel Cueto Noval, Karen Klein, Guillermo
Pascual Perez, Krzysztof Z Pietrzak, and Michael Walter. “CoCoA: Concurrent Continuous
Group Key Agreement.” In Advances in Cryptology – EUROCRYPT 2022, 13276:815–844.
Cham: Springer Nature, 2022. https://doi.org/10.1007/978-3-031-07085-3_28.'
ieee: 'J. Alwen et al., “CoCoA: Concurrent continuous group key agreement,”
in Advances in Cryptology – EUROCRYPT 2022, Trondheim, Norway, 2022, vol.
13276, pp. 815–844.'
ista: 'Alwen J, Auerbach B, Cueto Noval M, Klein K, Pascual Perez G, Pietrzak KZ,
Walter M. 2022. CoCoA: Concurrent continuous group key agreement. Advances in
Cryptology – EUROCRYPT 2022. EUROCRYPT: Theory and Applications of Cryptology
and Information Security, LNCS, vol. 13276, 815–844.'
mla: 'Alwen, Joël, et al. “CoCoA: Concurrent Continuous Group Key Agreement.” Advances
in Cryptology – EUROCRYPT 2022, vol. 13276, Springer Nature, 2022, pp. 815–844,
doi:10.1007/978-3-031-07085-3_28.'
short: J. Alwen, B. Auerbach, M. Cueto Noval, K. Klein, G. Pascual Perez, K.Z. Pietrzak,
M. Walter, in:, Advances in Cryptology – EUROCRYPT 2022, Springer Nature, Cham,
2022, pp. 815–844.
conference:
end_date: 2022-06-03
location: Trondheim, Norway
name: 'EUROCRYPT: Theory and Applications of Cryptology and Information Security'
start_date: 2022-05-30
corr_author: '1'
date_created: 2022-06-30T16:48:00Z
date_published: 2022-05-25T00:00:00Z
date_updated: 2026-10-16T08:11:07Z
day: '25'
department:
- _id: GradSch
- _id: KrPi
doi: 10.1007/978-3-031-07085-3_28
ec_funded: 1
external_id:
isi:
- '000832305300028'
fulldoi: https://doi.org/10.1007/978-3-031-07085-3_28
intvolume: ' 13276'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://eprint.iacr.org/2022/251
month: '05'
oa: 1
oa_version: Preprint
page: 815–844
place: Cham
project:
- _id: 258AA5B2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '682815'
name: Teaching Old Crypto New Tricks
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: Advances in Cryptology – EUROCRYPT 2022
publication_identifier:
eisbn:
- '9783031070853'
eissn:
- 1611-3349
isbn:
- '9783031070846'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '18088'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: 'CoCoA: Concurrent continuous group key agreement'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13276
year: '2022'
...
---
_id: '10787'
abstract:
- lang: eng
text: "A species distributed across diverse environments may adapt to local conditions.
We ask how quickly such a species changes its range in response to changed conditions.
Szép et al. (Szép E, Sachdeva H, Barton NH. 2021 Polygenic local adaptation in
metapopulations: a stochastic eco-evolutionary model. Evolution75, 1030–1045 (doi:10.1111/evo.14210))
used the infinite island model to find the stationary distribution of allele frequencies
and deme sizes. We extend this to find how a metapopulation responds to changes
in carrying capacity, selection strength, or migration rate when deme sizes are
fixed. We further develop a ‘fixed-state’ approximation. Under this approximation,
polymorphism is only possible for a narrow range of habitat proportions when selection
is weak compared to drift, but for a much wider range otherwise. When rates of
selection or migration relative to drift change in a single deme of the metapopulation,
the population takes a time of order m−1 to reach the new equilibrium. However,
even with many loci, there can be substantial fluctuations in net adaptation,
because at each locus, alleles randomly get lost or fixed. Thus, in a finite metapopulation,
variation may gradually be lost by chance, even if it would persist in an infinite
metapopulation. When conditions change across the whole metapopulation, there
can be rapid change, which is predicted well by the fixed-state approximation.
This work helps towards an understanding of how metapopulations extend their range
across diverse environments.\r\nThis article is part of the theme issue ‘Species’
ranges in the face of changing environments (Part II)’."
acknowledgement: This research was partly funded by the Austrian Science Fund (FWF)
[FWF P-32896B].
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Oluwafunmilola O
full_name: Olusanya, Oluwafunmilola O
id: 41AD96DC-F248-11E8-B48F-1D18A9856A87
last_name: Olusanya
orcid: 0000-0003-1971-8314
citation:
ama: 'Barton NH, Olusanya OO. The response of a metapopulation to a changing environment.
Philosophical Transactions of the Royal Society B: Biological Sciences.
2022;377(1848). doi:10.1098/rstb.2021.0009'
apa: 'Barton, N. H., & Olusanya, O. O. (2022). The response of a metapopulation
to a changing environment. Philosophical Transactions of the Royal Society
B: Biological Sciences. The Royal Society. https://doi.org/10.1098/rstb.2021.0009'
chicago: 'Barton, Nicholas H, and Oluwafunmilola O Olusanya. “The Response of a
Metapopulation to a Changing Environment.” Philosophical Transactions of the
Royal Society B: Biological Sciences. The Royal Society, 2022. https://doi.org/10.1098/rstb.2021.0009.'
ieee: 'N. H. Barton and O. O. Olusanya, “The response of a metapopulation to a changing
environment,” Philosophical Transactions of the Royal Society B: Biological
Sciences, vol. 377, no. 1848. The Royal Society, 2022.'
ista: 'Barton NH, Olusanya OO. 2022. The response of a metapopulation to a changing
environment. Philosophical Transactions of the Royal Society B: Biological Sciences.
377(1848).'
mla: 'Barton, Nicholas H., and Oluwafunmilola O. Olusanya. “The Response of a Metapopulation
to a Changing Environment.” Philosophical Transactions of the Royal Society
B: Biological Sciences, vol. 377, no. 1848, The Royal Society, 2022, doi:10.1098/rstb.2021.0009.'
short: 'N.H. Barton, O.O. Olusanya, Philosophical Transactions of the Royal Society
B: Biological Sciences 377 (2022).'
corr_author: '1'
date_created: 2022-02-21T16:08:10Z
date_published: 2022-04-11T00:00:00Z
date_updated: 2026-10-21T08:24:47Z
day: '11'
ddc:
- '570'
department:
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- _id: NiBa
doi: 10.1098/rstb.2021.0009
external_id:
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date_created: 2022-08-02T06:14:32Z
date_updated: 2022-08-02T06:14:32Z
file_id: '11719'
file_name: 2022_PhilosophicalTransactionsRSB_Barton.pdf
file_size: 1349672
relation: main_file
success: 1
file_date_updated: 2022-08-02T06:14:32Z
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intvolume: ' 377'
isi: 1
issue: '1848'
keyword:
- General Agricultural and Biological Sciences
- General Biochemistry
- Genetics and Molecular Biology
language:
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month: '04'
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pmid: 1
project:
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grant_number: P32896
name: Causes and consequences of population fragmentation
publication: 'Philosophical Transactions of the Royal Society B: Biological Sciences'
publication_identifier:
eissn:
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issn:
- 0962-8436
publication_status: published
publisher: The Royal Society
quality_controlled: '1'
related_material:
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scopus_import: '1'
status: public
title: The response of a metapopulation to a changing environment
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 377
year: '2022'
...
---
_id: '10658'
abstract:
- lang: eng
text: We analyse how migration from a large mainland influences genetic load and
population numbers on an island, in a scenario where fitness-affecting variants
are unconditionally deleterious, and where numbers decline with increasing load.
Our analysis shows that migration can have qualitatively different effects, depending
on the total mutation target and fitness effects of deleterious variants. In particular,
we find that populations exhibit a genetic Allee effect across a wide range of
parameter combinations, when variants are partially recessive, cycling between
low-load (large-population) and high-load (sink) states. Increased migration reduces
load in the sink state (by increasing heterozygosity) but further inflates load
in the large-population state (by hindering purging). We identify various critical
parameter thresholds at which one or other stable state collapses, and discuss
how these thresholds are influenced by the genetic versus demographic effects
of migration. Our analysis is based on a ‘semi-deterministic’ analysis, which
accounts for genetic drift but neglects demographic stochasticity. We also compare
against simulations which account for both demographic stochasticity and drift.
Our results clarify the importance of gene flow as a key determinant of extinction
risk in peripheral populations, even in the absence of ecological gradients. This
article is part of the theme issue ‘Species’ ranges in the face of changing environments
(part I)’.
acknowledgement: This research was partly funded by the Austrian Science Fund (FWF)
(grant no. P-32896B).
article_number: '20210010'
article_processing_charge: No
article_type: original
author:
- first_name: Himani
full_name: Sachdeva, Himani
last_name: Sachdeva
- first_name: Oluwafunmilola O
full_name: Olusanya, Oluwafunmilola O
id: 41AD96DC-F248-11E8-B48F-1D18A9856A87
last_name: Olusanya
orcid: 0000-0003-1971-8314
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Sachdeva H, Olusanya OO, Barton NH. Genetic load and extinction in peripheral
populations: The roles of migration, drift and demographic stochasticity. Philosophical
Transactions of the Royal Society B. 2022;377(1846). doi:10.1098/rstb.2021.0010'
apa: 'Sachdeva, H., Olusanya, O. O., & Barton, N. H. (2022). Genetic load and
extinction in peripheral populations: The roles of migration, drift and demographic
stochasticity. Philosophical Transactions of the Royal Society B. The Royal
Society. https://doi.org/10.1098/rstb.2021.0010'
chicago: 'Sachdeva, Himani, Oluwafunmilola O Olusanya, and Nicholas H Barton. “Genetic
Load and Extinction in Peripheral Populations: The Roles of Migration, Drift and
Demographic Stochasticity.” Philosophical Transactions of the Royal Society
B. The Royal Society, 2022. https://doi.org/10.1098/rstb.2021.0010.'
ieee: 'H. Sachdeva, O. O. Olusanya, and N. H. Barton, “Genetic load and extinction
in peripheral populations: The roles of migration, drift and demographic stochasticity,”
Philosophical Transactions of the Royal Society B, vol. 377, no. 1846.
The Royal Society, 2022.'
ista: 'Sachdeva H, Olusanya OO, Barton NH. 2022. Genetic load and extinction in
peripheral populations: The roles of migration, drift and demographic stochasticity.
Philosophical Transactions of the Royal Society B. 377(1846), 20210010.'
mla: 'Sachdeva, Himani, et al. “Genetic Load and Extinction in Peripheral Populations:
The Roles of Migration, Drift and Demographic Stochasticity.” Philosophical
Transactions of the Royal Society B, vol. 377, no. 1846, 20210010, The Royal
Society, 2022, doi:10.1098/rstb.2021.0010.'
short: H. Sachdeva, O.O. Olusanya, N.H. Barton, Philosophical Transactions of the
Royal Society B 377 (2022).
date_created: 2022-01-24T10:34:53Z
date_published: 2022-01-24T00:00:00Z
date_updated: 2026-10-21T08:24:47Z
day: '24'
ddc:
- '576'
department:
- _id: GradSch
- _id: NiBa
doi: 10.1098/rstb.2021.0010
external_id:
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pmid:
- '35067097'
file:
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checksum: 04ca9e2f0e344d680b947f2457df8d0a
content_type: application/pdf
creator: oolusany
date_created: 2022-01-24T10:34:45Z
date_updated: 2022-01-24T10:34:45Z
file_id: '10659'
file_name: rstb.2021.0010.pdf
file_size: 1845792
relation: main_file
file_date_updated: 2022-01-24T10:34:45Z
fulldoi: https://doi.org/10.1098/rstb.2021.0010
has_accepted_license: '1'
intvolume: ' 377'
isi: 1
issue: '1846'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: c08d3278-5a5b-11eb-8a69-fdb09b55f4b8
grant_number: P32896
name: Causes and consequences of population fragmentation
publication: Philosophical Transactions of the Royal Society B
publication_identifier:
eissn:
- 1471-2970
issn:
- 0962-8436
publication_status: published
publisher: The Royal Society
quality_controlled: '1'
related_material:
link:
- relation: earlier_version
url: https://doi.org/10.1101/2021.08.05.455207
record:
- id: '14711'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: 'Genetic load and extinction in peripheral populations: The roles of migration,
drift and demographic stochasticity'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 377
year: '2022'
...
---
OA_place: repository
OA_type: green
_id: '23180'
abstract:
- lang: eng
text: Defense against pathogens and parasites requires substantial investment of
energy and resources on part of the host. This makes the host immune function
dependent on availability and accessibility of resources. A resource deprived
host is therefore expected to be more susceptible to infections, although empirical
results do not always align with this prediction. Limiting host access to resources
can additionally impact within-host pathogen numbers, either directly by altering
the amount of resources available to the pathogens for proliferation or indirectly
by altering the efficiency of the host immune system. We tested for the effects
of host starvation (complete deprivation of resources) on susceptibility to bacterial
pathogens, and within-host pathogen proliferation, in Drosophila melanogaster
females. Our results show that starvation increases post-infection mortality of
the host, but in a pathogen-specific manner. This increase in mortality is always
accompanied by increased within-host pathogen proliferation. We therefore propose
that starvation compromises host resistance to bacterial infections in Drosophila
melanogaster females thereby increasing susceptibility to infections.
article_processing_charge: No
author:
- first_name: Aabeer
full_name: Basu, Aabeer
last_name: Basu
- first_name: Aparajita
full_name: Singh, Aparajita
last_name: Singh
- first_name: Suhaas
full_name: Sehgal, Suhaas
last_name: Sehgal
- first_name: Tanvi
full_name: Madaan, Tanvi
last_name: Madaan
- first_name: Nagaraj Guru
full_name: Prasad, Nagaraj Guru
last_name: Prasad
citation:
ama: Basu A, Singh A, Sehgal S, Madaan T, Prasad NG. Starvation increases susceptibility
to bacterial infection and promotes systemic pathogen proliferation in Drosophila
melanogaster females. 2022. doi:10.5061/dryad.pvmcvdnp8
apa: Basu, A., Singh, A., Sehgal, S., Madaan, T., & Prasad, N. G. (2022). Starvation
increases susceptibility to bacterial infection and promotes systemic pathogen
proliferation in Drosophila melanogaster females. Dryad. https://doi.org/10.5061/dryad.pvmcvdnp8
chicago: Basu, Aabeer, Aparajita Singh, Suhaas Sehgal, Tanvi Madaan, and Nagaraj
Guru Prasad. “Starvation Increases Susceptibility to Bacterial Infection and Promotes
Systemic Pathogen Proliferation in Drosophila Melanogaster Females.” Dryad, 2022.
https://doi.org/10.5061/dryad.pvmcvdnp8.
ieee: A. Basu, A. Singh, S. Sehgal, T. Madaan, and N. G. Prasad, “Starvation increases
susceptibility to bacterial infection and promotes systemic pathogen proliferation
in Drosophila melanogaster females.” Dryad, 2022.
ista: Basu A, Singh A, Sehgal S, Madaan T, Prasad NG. 2022. Starvation increases
susceptibility to bacterial infection and promotes systemic pathogen proliferation
in Drosophila melanogaster females, Dryad, 10.5061/dryad.pvmcvdnp8.
mla: Basu, Aabeer, et al. Starvation Increases Susceptibility to Bacterial Infection
and Promotes Systemic Pathogen Proliferation in Drosophila Melanogaster Females.
Dryad, 2022, doi:10.5061/dryad.pvmcvdnp8.
short: A. Basu, A. Singh, S. Sehgal, T. Madaan, N.G. Prasad, (2022).
date_created: 2026-10-21T10:42:59Z
date_published: 2022-05-17T00:00:00Z
date_updated: 2026-10-21T10:43:22Z
day: '17'
department:
- _id: SyCr
doi: 10.5061/dryad.pvmcvdnp8
fulldoi: https://doi.org/10.5061/dryad.pvmcvdnp8
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.pvmcvdnp8
month: '05'
oa: 1
oa_version: None
publisher: Dryad
related_material:
record:
- id: '18171'
relation: used_in_publication
status: public
status: public
title: Starvation increases susceptibility to bacterial infection and promotes systemic
pathogen proliferation in Drosophila melanogaster females
type: research_data_reference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
year: '2022'
...
---
OA_place: repository
_id: '17157'
abstract:
- lang: eng
text: An action of a complex reductive group G on a smooth projective variety X
is regular when all regular unipotent elements in G act with finitely many fixed
points. Then the complex G-equivariant cohomology ring of X is isomorphic to the
coordinate ring of a certain regular fixed point scheme. Examples include partial
flag varieties, smooth Schubert varieties and Bott-Samelson varieties. We also
show that a more general version of the fixed point scheme allows a generalisation
to GKM spaces, such as toric varieties.
article_number: '2212.11836'
article_processing_charge: No
arxiv: 1
author:
- first_name: Tamás
full_name: Hausel, Tamás
id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
last_name: Hausel
orcid: 0000-0002-9582-2634
- first_name: Kamil P
full_name: Rychlewicz, Kamil P
id: 85A07246-A8BF-11E9-B4FA-D9E3E5697425
last_name: Rychlewicz
citation:
ama: Hausel T, Rychlewicz KP. Spectrum of equivariant cohomology as a fixed point
scheme. arXiv. doi:10.48550/arXiv.2212.11836
apa: Hausel, T., & Rychlewicz, K. P. (n.d.). Spectrum of equivariant cohomology
as a fixed point scheme. arXiv. https://doi.org/10.48550/arXiv.2212.11836
chicago: Hausel, Tamás, and Kamil P Rychlewicz. “Spectrum of Equivariant Cohomology
as a Fixed Point Scheme.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2212.11836.
ieee: T. Hausel and K. P. Rychlewicz, “Spectrum of equivariant cohomology as a fixed
point scheme,” arXiv. .
ista: Hausel T, Rychlewicz KP. Spectrum of equivariant cohomology as a fixed point
scheme. arXiv, 2212.11836.
mla: Hausel, Tamás, and Kamil P. Rychlewicz. “Spectrum of Equivariant Cohomology
as a Fixed Point Scheme.” ArXiv, 2212.11836, doi:10.48550/arXiv.2212.11836.
short: T. Hausel, K.P. Rychlewicz, ArXiv (n.d.).
date_created: 2024-06-23T15:01:27Z
date_published: 2022-12-22T00:00:00Z
date_updated: 2026-10-21T11:00:24Z
day: '22'
department:
- _id: GradSch
- _id: TaHa
doi: 10.48550/arXiv.2212.11836
external_id:
arxiv:
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fulldoi: https://doi.org/10.48550/arXiv.2212.11836
language:
- iso: eng
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month: '12'
oa: 1
oa_version: Preprint
publication: arXiv
publication_status: draft
related_material:
record:
- id: '19071'
relation: later_version
status: public
- id: '17156'
relation: dissertation_contains
status: public
status: public
title: Spectrum of equivariant cohomology as a fixed point scheme
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
OA_place: repository
_id: '18293'
abstract:
- lang: eng
text: Given a non-singular diagonal cubic hypersurface X⊂Pn−1 over Fq(t) with char(Fq)≠3,
we show that the number of rational points of height at most |P| is O(|P|3+ε)
for n=6 and O(|P|2+ε) for n=4. In fact, if n=4 and char(Fq)>3 we prove that the
number of rational points away from any rational line contained in X is bounded
by O(|P|3/2+ε). From the result in 6 variables we deduce weak approximation for
diagonal cubic hypersurfaces for n≥7 over Fq(t) when char(Fq)>3 and handle Waring's
problem for cubes in 7 variables over Fq(t) when char(Fq)≠3. Our results answer
a question of Davenport regarding the number of solutions of bounded height to
x31+x32+x33=x34+x35+x36 with xi∈Fq[t].
article_number: '2208.05422'
article_processing_charge: No
arxiv: 1
author:
- first_name: Jakob
full_name: Glas, Jakob
id: d6423cba-dc74-11ea-a0a7-ee61689ff5fb
last_name: Glas
- first_name: Leonhard
full_name: Hochfilzer, Leonhard
last_name: Hochfilzer
citation:
ama: Glas J, Hochfilzer L. On a question of Davenport and diagonal cubic forms over
Fq(t). arXiv. doi:10.48550/arXiv.2208.05422
apa: Glas, J., & Hochfilzer, L. (n.d.). On a question of Davenport and diagonal
cubic forms over Fq(t). arXiv. https://doi.org/10.48550/arXiv.2208.05422
chicago: Glas, Jakob, and Leonhard Hochfilzer. “On a Question of Davenport and Diagonal
Cubic Forms over Fq(T).” ArXiv, n.d. https://doi.org/10.48550/arXiv.2208.05422.
ieee: J. Glas and L. Hochfilzer, “On a question of Davenport and diagonal cubic
forms over Fq(t),” arXiv. .
ista: Glas J, Hochfilzer L. On a question of Davenport and diagonal cubic forms
over Fq(t). arXiv, 2208.05422.
mla: Glas, Jakob, and Leonhard Hochfilzer. “On a Question of Davenport and Diagonal
Cubic Forms over Fq(T).” ArXiv, 2208.05422, doi:10.48550/arXiv.2208.05422.
short: J. Glas, L. Hochfilzer, ArXiv (n.d.).
corr_author: '1'
das_tickbox: '0'
date_created: 2024-10-10T12:46:41Z
date_published: 2022-08-10T00:00:00Z
date_updated: 2026-10-21T11:06:29Z
day: '10'
department:
- _id: TiBr
doi: 10.48550/arXiv.2208.05422
external_id:
arxiv:
- '2208.05422'
fulldoi: https://doi.org/10.48550/arXiv.2208.05422
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2208.05422
month: '08'
oa: 1
oa_version: Preprint
publication: arXiv
publication_status: draft
related_material:
record:
- id: '18132'
relation: dissertation_contains
status: public
- id: '18705'
relation: later_version
status: public
researchdata_availability: no
status: public
supplementarymaterial: no
title: On a question of Davenport and diagonal cubic forms over Fq(t)
type: preprint
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
year: '2022'
...
---
_id: '11355'
abstract:
- lang: eng
text: "Contract-based design is a promising methodology for taming the complexity
of developing sophisticated systems. A formal contract distinguishes between assumptions,
which are constraints that the designer of a component puts on the environments
in which the component can be used safely, and guarantees, which are promises
that the designer asks from the team that implements the component. A theory of
formal contracts can be formalized as an interface theory, which supports the
composition and refinement of both assumptions and guarantees.\r\nAlthough there
is a rich landscape of contract-based design methods that address functional and
extra-functional properties, we present the first interface theory that is designed
for ensuring system-wide security properties. Our framework provides a refinement
relation and a composition operation that support both incremental design and
independent implementability. We develop our theory for both stateless and stateful
interfaces. We illustrate the applicability of our framework with an example inspired
from the automotive domain."
acknowledgement: This project has received funding from the European Union’s Horizon
2020 research and innovation programme under grant agreement No 956123 and was funded
in part by the FWF project W1255-N23 and by the ERC-2020-AdG 101020093.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Ezio
full_name: Bartocci, Ezio
last_name: Bartocci
- first_name: Thomas
full_name: Ferrere, Thomas
id: 40960E6E-F248-11E8-B48F-1D18A9856A87
last_name: Ferrere
orcid: 0000-0001-5199-3143
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
- first_name: Dejan
full_name: Nickovic, Dejan
id: 41BCEE5C-F248-11E8-B48F-1D18A9856A87
last_name: Nickovic
- first_name: Ana Oliveira
full_name: Da Costa, Ana Oliveira
last_name: Da Costa
citation:
ama: 'Bartocci E, Ferrere T, Henzinger TA, Nickovic D, Da Costa AO. Information-flow
interfaces. In: Fundamental Approaches to Software Engineering. Vol 13241.
Springer Nature; 2022:3-22. doi:10.1007/978-3-030-99429-7_1'
apa: 'Bartocci, E., Ferrere, T., Henzinger, T. A., Nickovic, D., & Da Costa,
A. O. (2022). Information-flow interfaces. In Fundamental Approaches to Software
Engineering (Vol. 13241, pp. 3–22). Munich, Germany: Springer Nature. https://doi.org/10.1007/978-3-030-99429-7_1'
chicago: Bartocci, Ezio, Thomas Ferrere, Thomas A Henzinger, Dejan Nickovic, and
Ana Oliveira Da Costa. “Information-Flow Interfaces.” In Fundamental Approaches
to Software Engineering, 13241:3–22. Springer Nature, 2022. https://doi.org/10.1007/978-3-030-99429-7_1.
ieee: E. Bartocci, T. Ferrere, T. A. Henzinger, D. Nickovic, and A. O. Da Costa,
“Information-flow interfaces,” in Fundamental Approaches to Software Engineering,
Munich, Germany, 2022, vol. 13241, pp. 3–22.
ista: 'Bartocci E, Ferrere T, Henzinger TA, Nickovic D, Da Costa AO. 2022. Information-flow
interfaces. Fundamental Approaches to Software Engineering. FASE: Fundamental
Approaches to Software Engineering, LNCS, vol. 13241, 3–22.'
mla: Bartocci, Ezio, et al. “Information-Flow Interfaces.” Fundamental Approaches
to Software Engineering, vol. 13241, Springer Nature, 2022, pp. 3–22, doi:10.1007/978-3-030-99429-7_1.
short: E. Bartocci, T. Ferrere, T.A. Henzinger, D. Nickovic, A.O. Da Costa, in:,
Fundamental Approaches to Software Engineering, Springer Nature, 2022, pp. 3–22.
conference:
end_date: 2022-04-07
location: Munich, Germany
name: 'FASE: Fundamental Approaches to Software Engineering'
start_date: 2022-04-02
date_created: 2022-05-08T22:01:44Z
date_published: 2022-03-29T00:00:00Z
date_updated: 2026-10-21T12:02:28Z
day: '29'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1007/978-3-030-99429-7_1
ec_funded: 1
external_id:
isi:
- '000782393600001'
file:
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checksum: 7f6f860b20b8de2a249e9c1b4eee15cf
content_type: application/pdf
creator: dernst
date_created: 2022-05-09T06:52:44Z
date_updated: 2022-05-09T06:52:44Z
file_id: '11357'
file_name: 2022_LNCS_Bartocci.pdf
file_size: 479146
relation: main_file
success: 1
file_date_updated: 2022-05-09T06:52:44Z
fulldoi: https://doi.org/10.1007/978-3-030-99429-7_1
has_accepted_license: '1'
intvolume: ' 13241'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 3-22
project:
- _id: 62781420-2b32-11ec-9570-8d9b63373d4d
call_identifier: H2020
grant_number: '101020093'
name: Vigilant Algorithmic Monitoring of Software
publication: Fundamental Approaches to Software Engineering
publication_identifier:
eissn:
- 1611-3349
isbn:
- '9783030994280'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
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relation: extended_version
status: public
scopus_import: '1'
status: public
title: Information-flow interfaces
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13241
year: '2022'
...
---
_id: '12508'
abstract:
- lang: eng
text: "We explore the notion of history-determinism in the context of timed automata
(TA). History-deterministic automata are those in which nondeterminism can be
resolved on the fly, based on the run constructed thus far. History-determinism
is a robust property that admits different game-based characterisations, and history-deterministic
specifications allow for game-based verification without an expensive determinization
step.\r\nWe show yet another characterisation of history-determinism in terms
of fair simulation, at the general level of labelled transition systems: a system
is history-deterministic precisely if and only if it fairly simulates all language
smaller systems.\r\nFor timed automata over infinite timed words it is known that
universality is undecidable for Büchi TA. We show that for history-deterministic
TA with arbitrary parity acceptance, timed universality, inclusion, and synthesis
all remain decidable and are ExpTime-complete.\r\nFor the subclass of TA with
safety or reachability acceptance, we show that checking whether such an automaton
is history-deterministic is decidable (in ExpTime), and history-deterministic
TA with safety acceptance are effectively determinizable without introducing new
automata states."
acknowledgement: "Thomas A. Henzinger: This work was supported in part by the ERC-2020-AdG
101020093.\r\nPatrick Totzke: acknowledges support from the EPSRC, project no. EP/V025848/1.\r\n"
alternative_title:
- LIPIcs
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
- first_name: Karoliina
full_name: Lehtinen, Karoliina
last_name: Lehtinen
- first_name: Patrick
full_name: Totzke, Patrick
last_name: Totzke
citation:
ama: 'Henzinger TA, Lehtinen K, Totzke P. History-deterministic timed automata.
In: 33rd International Conference on Concurrency Theory. Vol 243. Schloss
Dagstuhl - Leibniz-Zentrum für Informatik; 2022:14:1-14:21. doi:10.4230/LIPIcs.CONCUR.2022.14'
apa: 'Henzinger, T. A., Lehtinen, K., & Totzke, P. (2022). History-deterministic
timed automata. In 33rd International Conference on Concurrency Theory
(Vol. 243, p. 14:1-14:21). Warsaw, Poland: Schloss Dagstuhl - Leibniz-Zentrum
für Informatik. https://doi.org/10.4230/LIPIcs.CONCUR.2022.14'
chicago: Henzinger, Thomas A, Karoliina Lehtinen, and Patrick Totzke. “History-Deterministic
Timed Automata.” In 33rd International Conference on Concurrency Theory,
243:14:1-14:21. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2022. https://doi.org/10.4230/LIPIcs.CONCUR.2022.14.
ieee: T. A. Henzinger, K. Lehtinen, and P. Totzke, “History-deterministic timed
automata,” in 33rd International Conference on Concurrency Theory, Warsaw,
Poland, 2022, vol. 243, p. 14:1-14:21.
ista: 'Henzinger TA, Lehtinen K, Totzke P. 2022. History-deterministic timed automata.
33rd International Conference on Concurrency Theory. CONCUR: Conference on Concurrency
Theory, LIPIcs, vol. 243, 14:1-14:21.'
mla: Henzinger, Thomas A., et al. “History-Deterministic Timed Automata.” 33rd
International Conference on Concurrency Theory, vol. 243, Schloss Dagstuhl
- Leibniz-Zentrum für Informatik, 2022, p. 14:1-14:21, doi:10.4230/LIPIcs.CONCUR.2022.14.
short: T.A. Henzinger, K. Lehtinen, P. Totzke, in:, 33rd International Conference
on Concurrency Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2022,
p. 14:1-14:21.
conference:
end_date: 2022-09-16
location: Warsaw, Poland
name: 'CONCUR: Conference on Concurrency Theory'
start_date: 2022-09-13
corr_author: '1'
das_tickbox: '1'
date_created: 2023-02-05T17:24:23Z
date_published: 2022-09-06T00:00:00Z
date_updated: 2026-10-21T13:12:36Z
day: '06'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.4230/LIPIcs.CONCUR.2022.14
ec_funded: 1
file:
- access_level: open_access
checksum: 9e97e15628f66b2ad77f535bb0327dee
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creator: dernst
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success: 1
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has_accepted_license: '1'
intvolume: ' 243'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 14:1-14:21
project:
- _id: 62781420-2b32-11ec-9570-8d9b63373d4d
call_identifier: H2020
grant_number: '101020093'
name: Vigilant Algorithmic Monitoring of Software
publication: 33rd International Conference on Concurrency Theory
publication_identifier:
isbn:
- '9783959772464'
issn:
- 1868-8969
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
related_material:
record:
- id: '18530'
relation: later_version
status: public
scopus_import: '1'
status: public
title: History-deterministic timed automata
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 243
year: '2022'
...
---
_id: '10934'
abstract:
- lang: eng
text: 'FtsA is crucial for assembly of the E. coli divisome, as it dynamically links
cytoplasmic FtsZ filaments with transmembrane cell division proteins. FtsA allegedly
initiates cell division by switching from an inactive polymeric to an active monomeric
confirmation, which recruits downstream proteins and stabilizes FtsZ filaments.
Here, we use biochemical reconstitution experiments combined with quantitative
fluorescence microscopy to study divisome activation in vitro. We compare wildtype-FtsA
with FtsA-R286W, a constantly active gain-of-function mutant and find that R286W
outperforms the wildtype protein in replicating FtsZ treadmilling dynamics, stabilizing
FtsZ filaments and recruiting FtsN. We attribute these differences to a faster
membrane exchange of FtsA-R286W and its higher packing density below FtsZ filaments. Using
FRET microscopy, we find that FtsN binding does not compete with, but promotes
FtsA self-interaction. Our findings suggest a model where FtsA always forms dynamic
polymers on the membrane, which re-organize during assembly and activation of
the divisome. '
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: We acknowledge members of the Loose laboratory at IST Austria for
helpful discussions—in particular L. Lindorfer for his assistance with cloning and
purifications. We thank J. Löwe and T. Nierhaus (MRC-LMB Cambridge, UK) for sharing
unpublished work and helpful discussions, as well as D. Vavylonis and D. Rutkowski
(Lehigh University, Bethlehem, PA, USA) as well as S. Martin (University of Lausanne,
Switzerland) for sharing their code for FRAP analysis. We are also thankful for
the support by the Scientific Service Units (SSU) of IST Austria through resources
provided by the Imaging and Optics Facility (IOF) and the Lab Support Facility (LSF).
This work was supported by the European Research Council through grant ERC 2015-StG-679239
and by the Austrian Science Fund (FWF) StandAlone P34607 to M.L. and HFSP LT 000824/2016-L4
to N.B. For the purpose of open access, we have applied a CC BY public copyright
licence to any Author Accepted Manuscript version arising from this submission.
article_processing_charge: No
author:
- first_name: Philipp
full_name: Radler, Philipp
id: 40136C2A-F248-11E8-B48F-1D18A9856A87
last_name: Radler
orcid: ' 0000-0001-9198-2182 '
citation:
ama: Radler P. In vitro reconstitution of Escherichia coli divisome activation.
2022. doi:10.15479/AT:ISTA:10934
apa: Radler, P. (2022). In vitro reconstitution of Escherichia coli divisome activation.
Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:10934
chicago: Radler, Philipp. “In Vitro Reconstitution of Escherichia Coli Divisome
Activation.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/AT:ISTA:10934.
ieee: P. Radler, “In vitro reconstitution of Escherichia coli divisome activation.”
Institute of Science and Technology Austria, 2022.
ista: Radler P. 2022. In vitro reconstitution of Escherichia coli divisome activation,
Institute of Science and Technology Austria, 10.15479/AT:ISTA:10934.
mla: Radler, Philipp. In Vitro Reconstitution of Escherichia Coli Divisome Activation.
Institute of Science and Technology Austria, 2022, doi:10.15479/AT:ISTA:10934.
short: P. Radler, (2022).
contributor:
- contributor_type: supervisor
first_name: Martin
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
- contributor_type: researcher
first_name: Christoph M
id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
last_name: Sommer
- contributor_type: researcher
first_name: Paulo
last_name: Caldas
- contributor_type: researcher
first_name: David
id: B9577E20-AA38-11E9-AC9A-0930E6697425
last_name: Michalik
- contributor_type: researcher
first_name: Natalia
last_name: Baranova
corr_author: '1'
date_created: 2022-03-31T11:32:32Z
date_published: 2022-04-05T00:00:00Z
date_updated: 2026-11-07T23:30:05Z
day: '05'
ddc:
- '572'
department:
- _id: GradSch
- _id: MaLo
doi: 10.15479/AT:ISTA:10934
ec_funded: 1
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date_created: 2022-04-22T10:15:19Z
date_updated: 2022-04-22T10:15:19Z
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date_updated: 2022-03-31T12:57:36Z
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fulldoi: https://doi.org/10.15479/AT:ISTA:10934
has_accepted_license: '1'
keyword:
- Bacterial cell division
- in vitro reconstitution
- FtsZ
- FtsN
- FtsA
month: '04'
oa: 1
oa_version: Submitted Version
project:
- _id: 2595697A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '679239'
name: Self-Organization of the Bacterial Cell
- _id: fc38323b-9c52-11eb-aca3-ff8afb4a011d
grant_number: P34607
name: In vitro reconstitution of bacterial cell division
publisher: Institute of Science and Technology Austria
related_material:
link:
- description: A custom written code (FRAPdiff) to quantify the Off binding rate
and Diffusion coefficient of membrane bound proteins. Written by Christoph Sommer.
relation: software
url: https://doi.org/10.5281/zenodo.6400639
record:
- id: '11373'
relation: used_in_publication
status: public
- id: '14280'
relation: used_in_publication
status: public
status: public
title: In vitro reconstitution of Escherichia coli divisome activation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
OA_place: publisher
_id: '11196'
abstract:
- lang: eng
text: "One of the fundamental questions in Neuroscience is how the structure of
synapses and their physiological properties are related. While synaptic transmission
remains a dynamic process, electron microscopy provides images with comparably
low temporal resolution (Studer et al., 2014). The current work overcomes this
challenge and describes an improved “Flash and Freeze” technique (Watanabe et
al., 2013a; Watanabe et al., 2013b) to study synaptic transmission at the hippocampal
mossy fiber-CA3 pyramidal neuron synapses, using mouse acute brain slices and
organotypic slices culture. The improved method allowed for selective stimulation
of presynaptic mossy fiber boutons and the observation of synaptic vesicle pool
dynamics at the active zones. Our results uncovered several intriguing morphological
features of mossy fiber boutons. First, the docked vesicle pool was largely depleted
(more than 70%) after stimulation, implying that the docked synaptic vesicles
pool and readily releasable pool are vastly overlapping in mossy fiber boutons.
Second, the synaptic vesicles are skewed towards larger diameters, displaying
a wide range of sizes. An increase in the mean diameter of synaptic vesicles,
after single and repetitive stimulation, suggests that smaller vesicles have a
higher release probability. Third, we observed putative endocytotic structures
after moderate light stimulation, matching the timing of previously described
ultrafast endocytosis (Watanabe et al., 2013a; Delvendahl et al., 2016). \r\n\tIn
addition, synaptic transmission depends on a sophisticated system of protein machinery
and calcium channels (Südhof, 2013b), which amplifies the challenge in studying
synaptic communication as these interactions can be potentially modified during
synaptic plasticity. And although recent study elucidated the potential correlation
between physiological and morphological properties of synapses during synaptic
plasticity (Vandael et al., 2020), the molecular underpinning of it remains unknown.
Thus, the presented work tries to overcome this challenge and aims to pinpoint
changes in the molecular architecture at hippocampal mossy fiber bouton synapses
during short- and long-term potentiation (STP and LTP), we combined chemical potentiation,
with the application of a cyclic adenosine monophosphate agonist (i.e. forskolin)
and freeze-fracture replica immunolabelling. This method allowed the localization
of membrane-bound proteins with nanometer precision within the active zone, in
particular, P/Q-type calcium channels and synaptic vesicle priming proteins Munc13-1/2.
First, we found that the number of clusters of Munc13-1 in the mossy fiber bouton
active zone increased significantly during STP, but decreased to lower than the
control value during LTP. Secondly, although the distance between the calcium
channels and Munc13-1s did not change after induction of STP, it shortened during
the LTP phase. Additionally, forskolin did not affect Munc13-2 distribution during
STP and LTP. These results indicate the existence of two distinct mechanisms that
govern STP and LTP at mossy fiber bouton synapses: an increase in the readily
realizable pool in the case of STP and a potential increase in release probability
during LTP. “Flash and freeze” and functional electron microscopy, are versatile
methods that can be successfully applied to intact brain circuits to study synaptic
transmission even at the molecular level.\r\n"
acknowledged_ssus:
- _id: EM-Fac
- _id: PreCl
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Olena
full_name: Kim, Olena
id: 3F8ABDDA-F248-11E8-B48F-1D18A9856A87
last_name: Kim
orcid: 0000-0003-2344-1039
citation:
ama: Kim O. Nanoarchitecture of hippocampal mossy fiber-CA3 pyramidal neuron synapses.
2022. doi:10.15479/at:ista:11196
apa: Kim, O. (2022). Nanoarchitecture of hippocampal mossy fiber-CA3 pyramidal
neuron synapses. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:11196
chicago: Kim, Olena. “Nanoarchitecture of Hippocampal Mossy Fiber-CA3 Pyramidal
Neuron Synapses.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:11196.
ieee: O. Kim, “Nanoarchitecture of hippocampal mossy fiber-CA3 pyramidal neuron
synapses,” Institute of Science and Technology Austria, 2022.
ista: Kim O. 2022. Nanoarchitecture of hippocampal mossy fiber-CA3 pyramidal neuron
synapses. Institute of Science and Technology Austria.
mla: Kim, Olena. Nanoarchitecture of Hippocampal Mossy Fiber-CA3 Pyramidal Neuron
Synapses. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:11196.
short: O. Kim, Nanoarchitecture of Hippocampal Mossy Fiber-CA3 Pyramidal Neuron
Synapses, Institute of Science and Technology Austria, 2022.
corr_author: '1'
date_created: 2022-04-20T09:47:12Z
date_published: 2022-04-20T00:00:00Z
date_updated: 2026-06-18T10:49:27Z
day: '20'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: PeJo
- _id: GradSch
doi: 10.15479/at:ista:11196
ec_funded: 1
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has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: '132'
project:
- _id: 25BAF7B2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '708497'
name: Presynaptic calcium channels distribution and impact on coupling at the hippocampal
mossy fiber synapse
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '692692'
name: Biophysics and circuit function of a giant cortical glutamatergic synapse
- _id: 25C3DBB6-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W01205
name: Zellkommunikation in Gesundheit und Krankheit
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z00312
name: Synaptic communication in neuronal microcircuits
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '7473'
relation: part_of_dissertation
status: public
- id: '11222'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
title: Nanoarchitecture of hippocampal mossy fiber-CA3 pyramidal neuron synapses
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2022'
...
---
OA_place: publisher
_id: '11879'
abstract:
- lang: eng
text: "As the overall global mean surface temperature is increasing due to climate
change, plant\r\nadaptation to those stressful conditions is of utmost importance
for their survival. Plants are\r\nsessile organisms, thus to compensate for their
lack of mobility, they evolved a variety of\r\nmechanisms enabling them to flexibly
adjust their physiological, growth and developmental\r\nprocesses to fluctuating
temperatures and to survive in harsh environments. While these unique\r\nadaptation
abilities provide an important evolutionary advantage, overall modulation of plant\r\ngrowth
and developmental program due to non-optimal temperature negatively affects biomass\r\nproduction,
crop productivity or sensitivity to pathogens. Thus, understanding molecular\r\nprocesses
underlying plant adaptation to increased temperature can provide important\r\nresources
for breeding strategies to ensure sufficient agricultural food production.\r\nAn
increase in ambient temperature by a few degrees leads to profound changes in
organ growth\r\nincluding enhanced hypocotyl elongation, expansion of petioles,
hyponastic growth of leaves and\r\ncotyledons, collectively named thermomorphogenesis
(Casal & Balasubramanian, 2019). Auxin,\r\none of the best-studied growth hormones,
plays an essential role in this process by direct\r\nactivation of transcriptional
and non-transcriptional processes resulting in elongation growth\r\n(Majda & Robert,
2018).To modulate hypocotyl growth in response to high ambient temperature\r\n(hAT),
auxin needs to be redistributed accordingly. PINs, auxin efflux transporters,
are key\r\ncomponents of the polar auxin transport (PAT) machinery, which controls
the amount and\r\ndirection of auxin translocated in the plant tissues and organs(Adamowski
& Friml, 2015). Hence,\r\nPIN-mediated transport is tightly linked with thermo-morphogenesis,
and interference with PAT\r\nthrough either chemical or genetic means dramatically
affecting the adaptive responses to hAT.\r\nIntriguingly, despite the key role
of PIN mediated transport in growth response to hAT, whether\r\nand how PINs at
the level of expression adapt to fluctuation in temperature is scarcely\r\nunderstood.\r\nWith
genetic, molecular and advanced bio-imaging approaches, we demonstrate the role
of PIN\r\nauxin transporters in the regulation of hypocotyl growth in response
to hAT. We show that via\r\nadjustment of PIN3, PIN4 and PIN7 expression in cotyledons
and hypocotyls, auxin distribution is modulated thereby determining elongation
pattern of epidermal cells at hAT. Furthermore, we\r\nidentified three Zinc-Finger
(ZF) transcription factors as novel molecular components of the\r\nthermo-regulatory
network, which through negative regulation of PIN transcription adjust the\r\ntransport
of auxin at hAT. Our results suggest that the ZF-PIN module might be a part of
the\r\nnegative feedback loop attenuating the activity of the thermo-sensing pathway
to restrain\r\nexaggerated growth and developmental responses to hAT."
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: SSU
acknowledgement: I would like to acknowledge ISTA and all the people from the Scientific
Service Units and at ISTA, in particular Dorota Jaworska for excellent technical
and scientific support as well as ÖAW for funding my research for over 3 years (DOC
ÖAW Fellowship PR1022OEAW02).
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Christina
full_name: Artner, Christina
id: 45DF286A-F248-11E8-B48F-1D18A9856A87
last_name: Artner
citation:
ama: Artner C. Modulation of auxin transport via ZF proteins adjust plant response
to high ambient temperature. 2022. doi:10.15479/at:ista:11879
apa: Artner, C. (2022). Modulation of auxin transport via ZF proteins adjust
plant response to high ambient temperature. Institute of Science and Technology
Austria. https://doi.org/10.15479/at:ista:11879
chicago: Artner, Christina. “Modulation of Auxin Transport via ZF Proteins Adjust
Plant Response to High Ambient Temperature.” Institute of Science and Technology
Austria, 2022. https://doi.org/10.15479/at:ista:11879.
ieee: C. Artner, “Modulation of auxin transport via ZF proteins adjust plant response
to high ambient temperature,” Institute of Science and Technology Austria, 2022.
ista: Artner C. 2022. Modulation of auxin transport via ZF proteins adjust plant
response to high ambient temperature. Institute of Science and Technology Austria.
mla: Artner, Christina. Modulation of Auxin Transport via ZF Proteins Adjust
Plant Response to High Ambient Temperature. Institute of Science and Technology
Austria, 2022, doi:10.15479/at:ista:11879.
short: C. Artner, Modulation of Auxin Transport via ZF Proteins Adjust Plant Response
to High Ambient Temperature, Institute of Science and Technology Austria, 2022.
corr_author: '1'
date_created: 2022-08-17T07:58:53Z
date_published: 2022-08-17T00:00:00Z
date_updated: 2026-04-07T14:30:39Z
day: '17'
ddc:
- '580'
degree_awarded: PhD
department:
- _id: GradSch
- _id: EvBe
doi: 10.15479/at:ista:11879
file:
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checksum: a2c2fdc28002538840490bfa6a08b2cb
content_type: application/pdf
creator: cartner
date_created: 2022-08-17T12:08:49Z
date_updated: 2023-09-09T22:30:03Z
embargo: 2023-09-08
file_id: '11907'
file_name: ChristinaArtner_PhD_Thesis_2022.pdf
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relation: source_file
file_date_updated: 2023-09-09T22:30:03Z
fulldoi: https://doi.org/10.15479/at:ista:11879
has_accepted_license: '1'
keyword:
- high ambient temperature
- auxin
- PINs
- Zinc-Finger proteins
- thermomorphogenesis
- stress
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: '128'
project:
- _id: 2685A872-B435-11E9-9278-68D0E5697425
name: Hormonal regulation of plant adaptive responses to environmental signals
publication_identifier:
isbn:
- 978-3-99078-022-0
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
title: Modulation of auxin transport via ZF proteins adjust plant response to high
ambient temperature
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2022'
...
---
_id: '11373'
abstract:
- lang: eng
text: The actin-homologue FtsA is essential for E. coli cell division, as it links
FtsZ filaments in the Z-ring to transmembrane proteins. FtsA is thought to initiate
cell constriction by switching from an inactive polymeric to an active monomeric
conformation, which recruits downstream proteins and stabilizes the Z-ring. However,
direct biochemical evidence for this mechanism is missing. Here, we use reconstitution
experiments and quantitative fluorescence microscopy to study divisome activation
in vitro. By comparing wild-type FtsA with FtsA R286W, we find that this hyperactive
mutant outperforms FtsA WT in replicating FtsZ treadmilling dynamics, FtsZ filament
stabilization and recruitment of FtsN. We could attribute these differences to
a faster exchange and denser packing of FtsA R286W below FtsZ filaments. Using
FRET microscopy, we also find that FtsN binding promotes FtsA self-interaction.
We propose that in the active divisome FtsA and FtsN exist as a dynamic copolymer
that follows treadmilling filaments of FtsZ.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: We acknowledge members of the Loose laboratory at IST Austria for
helpful discussions—in particular L. Lindorfer for his assistance with cloning and
purifications. We thank J. Löwe and T. Nierhaus (MRC-LMB Cambridge, UK) for sharing
unpublished work and helpful discussions, as well as D. Vavylonis and D. Rutkowski
(Lehigh University, Bethlehem, PA, USA) and S. Martin (University of Lausanne, Switzerland)
for sharing their code for FRAP analysis. We are also thankful for the support by
the Scientific Service Units (SSU) of IST Austria through resources provided by
the Imaging and Optics Facility (IOF) and the Lab Support Facility (LSF). This work
was supported by the European Research Council through grant ERC 2015-StG-679239
and by the Austrian Science Fund (FWF) StandAlone P34607 to M.L. and HFSP LT 000824/2016-L4
to N.B. For the purpose of open access, we have applied a CC BY public copyright
licence to any Author Accepted Manuscript version arising from this submission.
article_number: '2635'
article_processing_charge: No
article_type: original
author:
- first_name: Philipp
full_name: Radler, Philipp
id: 40136C2A-F248-11E8-B48F-1D18A9856A87
last_name: Radler
orcid: '0000-0001-9198-2182 '
- first_name: Natalia S.
full_name: Baranova, Natalia S.
id: 38661662-F248-11E8-B48F-1D18A9856A87
last_name: Baranova
orcid: 0000-0002-3086-9124
- first_name: Paulo R
full_name: Dos Santos Caldas, Paulo R
id: 38FCDB4C-F248-11E8-B48F-1D18A9856A87
last_name: Dos Santos Caldas
orcid: 0000-0001-6730-4461
- first_name: Christoph M
full_name: Sommer, Christoph M
id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
last_name: Sommer
orcid: 0000-0003-1216-9105
- first_name: Maria D
full_name: Lopez Pelegrin, Maria D
id: 319AA9CE-F248-11E8-B48F-1D18A9856A87
last_name: Lopez Pelegrin
- first_name: David
full_name: Michalik, David
id: B9577E20-AA38-11E9-AC9A-0930E6697425
last_name: Michalik
- first_name: Martin
full_name: Loose, Martin
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
citation:
ama: Radler P, Baranova NS, Dos Santos Caldas PR, et al. In vitro reconstitution
of Escherichia coli divisome activation. Nature Communications. 2022;13.
doi:10.1038/s41467-022-30301-y
apa: Radler, P., Baranova, N. S., Dos Santos Caldas, P. R., Sommer, C. M., Lopez
Pelegrin, M. D., Michalik, D., & Loose, M. (2022). In vitro reconstitution
of Escherichia coli divisome activation. Nature Communications. Springer
Nature. https://doi.org/10.1038/s41467-022-30301-y
chicago: Radler, Philipp, Natalia S. Baranova, Paulo R Dos Santos Caldas, Christoph
M Sommer, Maria D Lopez Pelegrin, David Michalik, and Martin Loose. “In Vitro
Reconstitution of Escherichia Coli Divisome Activation.” Nature Communications.
Springer Nature, 2022. https://doi.org/10.1038/s41467-022-30301-y.
ieee: P. Radler et al., “In vitro reconstitution of Escherichia coli divisome
activation,” Nature Communications, vol. 13. Springer Nature, 2022.
ista: Radler P, Baranova NS, Dos Santos Caldas PR, Sommer CM, Lopez Pelegrin MD,
Michalik D, Loose M. 2022. In vitro reconstitution of Escherichia coli divisome
activation. Nature Communications. 13, 2635.
mla: Radler, Philipp, et al. “In Vitro Reconstitution of Escherichia Coli Divisome
Activation.” Nature Communications, vol. 13, 2635, Springer Nature, 2022,
doi:10.1038/s41467-022-30301-y.
short: P. Radler, N.S. Baranova, P.R. Dos Santos Caldas, C.M. Sommer, M.D. Lopez
Pelegrin, D. Michalik, M. Loose, Nature Communications 13 (2022).
corr_author: '1'
date_created: 2022-05-13T09:06:28Z
date_published: 2022-05-12T00:00:00Z
date_updated: 2026-11-07T23:30:05Z
day: '12'
ddc:
- '570'
department:
- _id: MaLo
doi: 10.1038/s41467-022-30301-y
ec_funded: 1
external_id:
isi:
- '000795171100037'
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checksum: 5af863ee1b95a0710f6ee864d68dc7a6
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creator: dernst
date_created: 2022-05-13T09:10:51Z
date_updated: 2022-05-13T09:10:51Z
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relation: main_file
success: 1
file_date_updated: 2022-05-13T09:10:51Z
fulldoi: https://doi.org/10.1038/s41467-022-30301-y
has_accepted_license: '1'
intvolume: ' 13'
isi: 1
keyword:
- General Physics and Astronomy
- General Biochemistry
- Genetics and Molecular Biology
- General Chemistry
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
project:
- _id: 2595697A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '679239'
name: Self-Organization of the Bacterial Cell
- _id: fc38323b-9c52-11eb-aca3-ff8afb4a011d
grant_number: P34607
name: In vitro reconstitution of bacterial cell division
publication: Nature Communications
publication_identifier:
issn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1038/s41467-022-34485-1
record:
- id: '10934'
relation: research_data
status: public
- id: '14280'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: In vitro reconstitution of Escherichia coli divisome activation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13
year: '2022'
...