---
_id: '15277'
abstract:
- lang: eng
  text: Alternative splicing generates multiple transcript and protein isoforms from
    a single gene and controls transcript intracellular localization and stability
    by coupling to mRNA export and nonsense-mediated mRNA decay (NMD). RNA interference
    (RNAi) is a potent mechanism to modulate gene expression. However, its interactions
    with alternative splicing are poorly understood. We used artificial microRNAs
    (amiRNAs, also termed shRNAmiR) to knockdown all splice variants of selected target
    genes in Arabidopsis thaliana. We found that splice variants, which vary by their
    protein-coding capacity, subcellular localization and sensitivity to NMD, are
    affected differentially by an amiRNA, although all of them contain the target
    site. Particular transcript isoforms escape amiRNA-mediated degradation due to
    their nuclear localization. The nuclear and NMD-sensitive isoforms mask RNAi action
    in alternatively spliced genes. Interestingly, Arabidopsis SPL genes, which undergo
    alternative splicing and are targets of miR156, are regulated in the same manner.
    Moreover, similar results were obtained in mammalian cells using siRNAs, indicating
    cross-kingdom conservation of these interactions among RNAi and splicing isoforms.
    Furthermore, we report that amiRNA can trigger artificial alternative splicing,
    thus expanding the RNAi functional repertoire. Our findings unveil novel interactions
    between different post-transcriptional processes in defining transcript fates
    and regulating gene expression.
article_processing_charge: No
article_type: original
author:
- first_name: Armin
  full_name: Fuchs, Armin
  last_name: Fuchs
- first_name: Stefan
  full_name: Riegler, Stefan
  last_name: Riegler
- first_name: Zahra
  full_name: Ayatollahi, Zahra
  last_name: Ayatollahi
- first_name: Nicola
  full_name: Cavallari, Nicola
  id: 457160E6-F248-11E8-B48F-1D18A9856A87
  last_name: Cavallari
- first_name: Luciana E
  full_name: Giono, Luciana E
  last_name: Giono
- first_name: Barbara A
  full_name: Nimeth, Barbara A
  last_name: Nimeth
- first_name: Krishna V
  full_name: Mutanwad, Krishna V
  last_name: Mutanwad
- first_name: Alois
  full_name: Schweighofer, Alois
  last_name: Schweighofer
- first_name: Doris
  full_name: Lucyshyn, Doris
  last_name: Lucyshyn
- first_name: Andrea
  full_name: Barta, Andrea
  last_name: Barta
- first_name: Ezequiel
  full_name: Petrillo, Ezequiel
  last_name: Petrillo
- first_name: Maria
  full_name: Kalyna, Maria
  last_name: Kalyna
citation:
  ama: 'Fuchs A, Riegler S, Ayatollahi Z, et al. Targeting alternative splicing by
    RNAi: From the differential impact on splice variants to triggering artificial
    pre-mRNA splicing. <i>Nucleic Acids Research</i>. 2021;49(2):1133-1151. doi:<a
    href="https://doi.org/10.1093/nar/gkaa1260">10.1093/nar/gkaa1260</a>'
  apa: 'Fuchs, A., Riegler, S., Ayatollahi, Z., Cavallari, N., Giono, L. E., Nimeth,
    B. A., … Kalyna, M. (2021). Targeting alternative splicing by RNAi: From the differential
    impact on splice variants to triggering artificial pre-mRNA splicing. <i>Nucleic
    Acids Research</i>. Oxford University Press. <a href="https://doi.org/10.1093/nar/gkaa1260">https://doi.org/10.1093/nar/gkaa1260</a>'
  chicago: 'Fuchs, Armin, Stefan Riegler, Zahra Ayatollahi, Nicola Cavallari, Luciana
    E Giono, Barbara A Nimeth, Krishna V Mutanwad, et al. “Targeting Alternative Splicing
    by RNAi: From the Differential Impact on Splice Variants to Triggering Artificial
    Pre-MRNA Splicing.” <i>Nucleic Acids Research</i>. Oxford University Press, 2021.
    <a href="https://doi.org/10.1093/nar/gkaa1260">https://doi.org/10.1093/nar/gkaa1260</a>.'
  ieee: 'A. Fuchs <i>et al.</i>, “Targeting alternative splicing by RNAi: From the
    differential impact on splice variants to triggering artificial pre-mRNA splicing,”
    <i>Nucleic Acids Research</i>, vol. 49, no. 2. Oxford University Press, pp. 1133–1151,
    2021.'
  ista: 'Fuchs A, Riegler S, Ayatollahi Z, Cavallari N, Giono LE, Nimeth BA, Mutanwad
    KV, Schweighofer A, Lucyshyn D, Barta A, Petrillo E, Kalyna M. 2021. Targeting
    alternative splicing by RNAi: From the differential impact on splice variants
    to triggering artificial pre-mRNA splicing. Nucleic Acids Research. 49(2), 1133–1151.'
  mla: 'Fuchs, Armin, et al. “Targeting Alternative Splicing by RNAi: From the Differential
    Impact on Splice Variants to Triggering Artificial Pre-MRNA Splicing.” <i>Nucleic
    Acids Research</i>, vol. 49, no. 2, Oxford University Press, 2021, pp. 1133–51,
    doi:<a href="https://doi.org/10.1093/nar/gkaa1260">10.1093/nar/gkaa1260</a>.'
  short: A. Fuchs, S. Riegler, Z. Ayatollahi, N. Cavallari, L.E. Giono, B.A. Nimeth,
    K.V. Mutanwad, A. Schweighofer, D. Lucyshyn, A. Barta, E. Petrillo, M. Kalyna,
    Nucleic Acids Research 49 (2021) 1133–1151.
date_created: 2024-04-03T08:02:09Z
date_published: 2021-01-25T00:00:00Z
date_updated: 2024-04-09T10:16:40Z
day: '25'
ddc:
- '570'
department:
- _id: EvBe
doi: 10.1093/nar/gkaa1260
external_id:
  pmid:
  - '33406240'
file:
- access_level: open_access
  checksum: d3c90660759a5d34ad43ba1def130462
  content_type: application/pdf
  creator: dernst
  date_created: 2024-04-09T10:14:39Z
  date_updated: 2024-04-09T10:14:39Z
  file_id: '15304'
  file_name: 2021_NucleicAcidsRes_Fuchs.pdf
  file_size: 6539791
  relation: main_file
  success: 1
file_date_updated: 2024-04-09T10:14:39Z
has_accepted_license: '1'
intvolume: '        49'
issue: '2'
keyword:
- Genetics
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 1133-1151
pmid: 1
publication: Nucleic Acids Research
publication_identifier:
  eissn:
  - 1362-4962
  issn:
  - 0305-1048
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
status: public
title: 'Targeting alternative splicing by RNAi: From the differential impact on splice
  variants to triggering artificial pre-mRNA splicing'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 49
year: '2021'
...
---
_id: '15278'
abstract:
- lang: eng
  text: ‘Dysbiosis’ of the adult gut microbiota, in response to challenges such as
    infection, altered diet, stress, and antibiotics treatment has been recently linked
    to pathological alteration of brain function and behavior. Moreover, gut microbiota
    composition constantly controls microglia maturation, as revealed by morphological
    observations and gene expression analysis. However, it is unclear whether microglia
    functional properties and crosstalk with neurons, known to shape and modulate
    synaptic development and function, are influenced by the gut microbiota. Here,
    we investigated how antibiotic-mediated alteration of the gut microbiota influences
    microglial and neuronal functions in adult mice hippocampus. Hippocampal microglia
    from adult mice treated with oral antibiotics exhibited increased microglia density,
    altered basal patrolling activity, and impaired process rearrangement in response
    to damage. Patch clamp recordings at CA3-CA1 synapses revealed that antibiotics
    treatment alters neuronal functions, reducing spontaneous postsynaptic glutamatergic
    currents and decreasing synaptic connectivity, without reducing dendritic spines
    density. Antibiotics treatment was unable to modulate synaptic function in CX3CR1-deficient
    mice, pointing to an involvement of microglia–neuron crosstalk through the CX3CL1/CX3CR1
    axis in the effect of dysbiosis on neuronal functions. Together, our findings
    show that antibiotic alteration of gut microbiota impairs synaptic efficacy, suggesting
    that CX3CL1/CX3CR1 signaling supporting microglia is a major player in in the
    gut–brain axis, and in particular in the gut microbiota-to-neuron communication
    pathway.
article_number: '2648'
article_processing_charge: Yes
article_type: original
author:
- first_name: Federica
  full_name: Cordella, Federica
  last_name: Cordella
- first_name: Caterina
  full_name: Sanchini, Caterina
  last_name: Sanchini
- first_name: Maria
  full_name: Rosito, Maria
  last_name: Rosito
- first_name: Laura
  full_name: Ferrucci, Laura
  last_name: Ferrucci
- first_name: Natalia
  full_name: Pediconi, Natalia
  last_name: Pediconi
- first_name: Barbara
  full_name: Cortese, Barbara
  last_name: Cortese
- first_name: Francesca
  full_name: Guerrieri, Francesca
  last_name: Guerrieri
- first_name: Giuseppe Rubens
  full_name: Pascucci, Giuseppe Rubens
  last_name: Pascucci
- first_name: Fabrizio
  full_name: Antonangeli, Fabrizio
  last_name: Antonangeli
- first_name: Giovanna
  full_name: Peruzzi, Giovanna
  last_name: Peruzzi
- first_name: Maria
  full_name: Giubettini, Maria
  last_name: Giubettini
- first_name: Bernadette
  full_name: Basilico, Bernadette
  id: 36035796-5ACA-11E9-A75E-7AF2E5697425
  last_name: Basilico
  orcid: 0000-0003-1843-3173
- first_name: Francesca
  full_name: Pagani, Francesca
  last_name: Pagani
- first_name: Alfonso
  full_name: Grimaldi, Alfonso
  last_name: Grimaldi
- first_name: Giuseppina
  full_name: D’Alessandro, Giuseppina
  last_name: D’Alessandro
- first_name: Cristina
  full_name: Limatola, Cristina
  last_name: Limatola
- first_name: Davide
  full_name: Ragozzino, Davide
  last_name: Ragozzino
- first_name: Silvia
  full_name: Di Angelantonio, Silvia
  last_name: Di Angelantonio
citation:
  ama: Cordella F, Sanchini C, Rosito M, et al. Antibiotics treatment modulates microglia–synapses
    interaction. <i>Cells</i>. 2021;10(10). doi:<a href="https://doi.org/10.3390/cells10102648">10.3390/cells10102648</a>
  apa: Cordella, F., Sanchini, C., Rosito, M., Ferrucci, L., Pediconi, N., Cortese,
    B., … Di Angelantonio, S. (2021). Antibiotics treatment modulates microglia–synapses
    interaction. <i>Cells</i>. MDPI. <a href="https://doi.org/10.3390/cells10102648">https://doi.org/10.3390/cells10102648</a>
  chicago: Cordella, Federica, Caterina Sanchini, Maria Rosito, Laura Ferrucci, Natalia
    Pediconi, Barbara Cortese, Francesca Guerrieri, et al. “Antibiotics Treatment
    Modulates Microglia–Synapses Interaction.” <i>Cells</i>. MDPI, 2021. <a href="https://doi.org/10.3390/cells10102648">https://doi.org/10.3390/cells10102648</a>.
  ieee: F. Cordella <i>et al.</i>, “Antibiotics treatment modulates microglia–synapses
    interaction,” <i>Cells</i>, vol. 10, no. 10. MDPI, 2021.
  ista: Cordella F, Sanchini C, Rosito M, Ferrucci L, Pediconi N, Cortese B, Guerrieri
    F, Pascucci GR, Antonangeli F, Peruzzi G, Giubettini M, Basilico B, Pagani F,
    Grimaldi A, D’Alessandro G, Limatola C, Ragozzino D, Di Angelantonio S. 2021.
    Antibiotics treatment modulates microglia–synapses interaction. Cells. 10(10),
    2648.
  mla: Cordella, Federica, et al. “Antibiotics Treatment Modulates Microglia–Synapses
    Interaction.” <i>Cells</i>, vol. 10, no. 10, 2648, MDPI, 2021, doi:<a href="https://doi.org/10.3390/cells10102648">10.3390/cells10102648</a>.
  short: F. Cordella, C. Sanchini, M. Rosito, L. Ferrucci, N. Pediconi, B. Cortese,
    F. Guerrieri, G.R. Pascucci, F. Antonangeli, G. Peruzzi, M. Giubettini, B. Basilico,
    F. Pagani, A. Grimaldi, G. D’Alessandro, C. Limatola, D. Ragozzino, S. Di Angelantonio,
    Cells 10 (2021).
date_created: 2024-04-03T08:02:52Z
date_published: 2021-10-04T00:00:00Z
date_updated: 2024-04-09T08:53:23Z
day: '04'
ddc:
- '610'
department:
- _id: GaNo
doi: 10.3390/cells10102648
external_id:
  pmid:
  - '34685628'
file:
- access_level: open_access
  checksum: 1a3b251ce82e2b9474b852d2abe5bb03
  content_type: application/pdf
  creator: dernst
  date_created: 2024-04-09T08:51:22Z
  date_updated: 2024-04-09T08:51:22Z
  file_id: '15303'
  file_name: 2021_Cells_Cordella.pdf
  file_size: 2196672
  relation: main_file
  success: 1
file_date_updated: 2024-04-09T08:51:22Z
has_accepted_license: '1'
intvolume: '        10'
issue: '10'
keyword:
- General Medicine
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
publication: Cells
publication_identifier:
  issn:
  - 2073-4409
publication_status: published
publisher: MDPI
quality_controlled: '1'
status: public
title: Antibiotics treatment modulates microglia–synapses interaction
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '2021'
...
---
_id: '15283'
article_processing_charge: No
article_type: original
author:
- first_name: William
  full_name: Nicolas, William
  last_name: Nicolas
- first_name: Florian
  full_name: Fäßler, Florian
  id: 404F5528-F248-11E8-B48F-1D18A9856A87
  last_name: Fäßler
  orcid: 0000-0001-7149-769X
- first_name: Elliot
  full_name: Meyerowitz, Elliot
  last_name: Meyerowitz
- first_name: Grant
  full_name: Jensen, Grant
  last_name: Jensen
citation:
  ama: Nicolas W, Fäßler F, Meyerowitz E, Jensen G. Peaking into the plant cell wall
    using cryo-FIB milling and electron cryo-tomography. <i>Microscopy and Microanalysis</i>.
    2021;27(S1):3024-3026. doi:<a href="https://doi.org/10.1017/s1431927621010503">10.1017/s1431927621010503</a>
  apa: Nicolas, W., Fäßler, F., Meyerowitz, E., &#38; Jensen, G. (2021). Peaking into
    the plant cell wall using cryo-FIB milling and electron cryo-tomography. <i>Microscopy
    and Microanalysis</i>. Oxford University Press. <a href="https://doi.org/10.1017/s1431927621010503">https://doi.org/10.1017/s1431927621010503</a>
  chicago: Nicolas, William, Florian Fäßler, Elliot Meyerowitz, and Grant Jensen.
    “Peaking into the Plant Cell Wall Using Cryo-FIB Milling and Electron Cryo-Tomography.”
    <i>Microscopy and Microanalysis</i>. Oxford University Press, 2021. <a href="https://doi.org/10.1017/s1431927621010503">https://doi.org/10.1017/s1431927621010503</a>.
  ieee: W. Nicolas, F. Fäßler, E. Meyerowitz, and G. Jensen, “Peaking into the plant
    cell wall using cryo-FIB milling and electron cryo-tomography,” <i>Microscopy
    and Microanalysis</i>, vol. 27, no. S1. Oxford University Press, pp. 3024–3026,
    2021.
  ista: Nicolas W, Fäßler F, Meyerowitz E, Jensen G. 2021. Peaking into the plant
    cell wall using cryo-FIB milling and electron cryo-tomography. Microscopy and
    Microanalysis. 27(S1), 3024–3026.
  mla: Nicolas, William, et al. “Peaking into the Plant Cell Wall Using Cryo-FIB Milling
    and Electron Cryo-Tomography.” <i>Microscopy and Microanalysis</i>, vol. 27, no.
    S1, Oxford University Press, 2021, pp. 3024–26, doi:<a href="https://doi.org/10.1017/s1431927621010503">10.1017/s1431927621010503</a>.
  short: W. Nicolas, F. Fäßler, E. Meyerowitz, G. Jensen, Microscopy and Microanalysis
    27 (2021) 3024–3026.
date_created: 2024-04-03T08:57:23Z
date_published: 2021-08-01T00:00:00Z
date_updated: 2024-04-09T07:55:56Z
day: '01'
department:
- _id: FlSc
doi: 10.1017/s1431927621010503
intvolume: '        27'
issue: S1
keyword:
- Instrumentation
language:
- iso: eng
month: '08'
oa_version: None
page: 3024-3026
publication: Microscopy and Microanalysis
publication_identifier:
  eissn:
  - 1435-8115
  issn:
  - 1431-9276
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
status: public
title: Peaking into the plant cell wall using cryo-FIB milling and electron cryo-tomography
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 27
year: '2021'
...
---
_id: '15284'
abstract:
- lang: eng
  text: "RevTerm is a static analysis tool for proving non-termination of integer
    C programs (possibly with non-determinism). RevTerm is an implementation of our
    method for non-termination proving presented in the paper “Proving Non-termination
    by Program Reversal”.\r\n\r\n"
article_processing_charge: No
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Ehsan Kafshdar
  full_name: Goharshady, Ehsan Kafshdar
  last_name: Goharshady
- first_name: Petr
  full_name: Novotný, Petr
  id: 3CC3B868-F248-11E8-B48F-1D18A9856A87
  last_name: Novotný
- first_name: Dorde
  full_name: Zikelic, Dorde
  id: 294AA7A6-F248-11E8-B48F-1D18A9856A87
  last_name: Zikelic
  orcid: 0000-0002-4681-1699
citation:
  ama: Chatterjee K, Goharshady EK, Novotný P, Zikelic D. RevTerm. 2021. doi:<a href="https://doi.org/10.1145/3410304">10.1145/3410304</a>
  apa: Chatterjee, K., Goharshady, E. K., Novotný, P., &#38; Zikelic, D. (2021). RevTerm.
    Association for Computing Machinery. <a href="https://doi.org/10.1145/3410304">https://doi.org/10.1145/3410304</a>
  chicago: Chatterjee, Krishnendu, Ehsan Kafshdar Goharshady, Petr Novotný, and Dorde
    Zikelic. “RevTerm.” Association for Computing Machinery, 2021. <a href="https://doi.org/10.1145/3410304">https://doi.org/10.1145/3410304</a>.
  ieee: K. Chatterjee, E. K. Goharshady, P. Novotný, and D. Zikelic, “RevTerm.” Association
    for Computing Machinery, 2021.
  ista: Chatterjee K, Goharshady EK, Novotný P, Zikelic D. 2021. RevTerm, Association
    for Computing Machinery, <a href="https://doi.org/10.1145/3410304">10.1145/3410304</a>.
  mla: Chatterjee, Krishnendu, et al. <i>RevTerm</i>. Association for Computing Machinery,
    2021, doi:<a href="https://doi.org/10.1145/3410304">10.1145/3410304</a>.
  short: K. Chatterjee, E.K. Goharshady, P. Novotný, D. Zikelic, (2021).
corr_author: '1'
date_created: 2024-04-03T09:00:42Z
date_published: 2021-06-01T00:00:00Z
date_updated: 2025-04-15T06:25:30Z
day: '01'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1145/3410304
has_accepted_license: '1'
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1145/3410304
month: '06'
oa: 1
oa_version: Published Version
publisher: Association for Computing Machinery
related_material:
  record:
  - id: '9644'
    relation: used_in_publication
    status: public
status: public
title: RevTerm
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '15285'
abstract:
- lang: eng
  text: Ever since the first publication of the standard communication protocol for
    computer-assisted electrocardiography (SCP-ECG), prENV 1064, in 1993, by the European
    Committee for Standardization (CEN), SCP-ECG has become a leading example in health
    informatics, enabling open, secure, and well-documented digital data exchange
    at a low cost, for quick and efficient cardiovascular disease detection and management.
    Based on the experiences gained, since the 1970s, in computerized electrocardiology,
    and on the results achieved by the pioneering, international cooperative research
    on common standards for quantitative electrocardiography (CSE), SCP-ECG was designed,
    from the beginning, to empower personalized medicine, thanks to serial ECG analysis.
    The fundamental concept behind SCP-ECG is to convey the necessary information
    for ECG re-analysis, serial comparison, and interpretation, and to structure the
    ECG data and metadata in sections that are mostly optional in order to fit all
    use cases. SCP-ECG is open to the storage of the ECG signal and ECG measurement
    data, whatever the ECG recording modality or computation method, and can store
    the over-reading trails and ECG annotations, as well as any computerized or medical
    interpretation reports. Only the encoding syntax and the semantics of the ECG
    descriptors and of the diagnosis codes are standardized. We present all of the
    landmarks in the development and publication of SCP-ECG, from the early 1990s
    to the 2009 International Organization for Standardization (ISO) SCP-ECG standards,
    including the latest version published by CEN in 2020, which now encompasses rest
    and stress ECGs, Holter recordings, and protocol-based trials.
acknowledgement: This research received no external funding. The authors thank the
  large number of researchers, engineers, cardiologists, and clinicians from academia,
  industry, and normalization organizations who contributed to the development and
  testing of the SCP-ECG standards.
article_processing_charge: Yes
article_type: review
author:
- first_name: Paul
  full_name: Rubel, Paul
  last_name: Rubel
- first_name: Jocelyne
  full_name: Fayn, Jocelyne
  last_name: Fayn
- first_name: Peter W.
  full_name: Macfarlane, Peter W.
  last_name: Macfarlane
- first_name: Danilo
  full_name: Pani, Danilo
  last_name: Pani
- first_name: Alois
  full_name: Schlögl, Alois
  id: 45BF87EE-F248-11E8-B48F-1D18A9856A87
  last_name: Schlögl
  orcid: 0000-0002-5621-8100
- first_name: Alpo
  full_name: Värri, Alpo
  last_name: Värri
citation:
  ama: 'Rubel P, Fayn J, Macfarlane PW, Pani D, Schlögl A, Värri A. The history and
    challenges of SCP-ECG: The standard communication protocol for computer-assisted
    electrocardiography. <i>Hearts</i>. 2021;2(3):384-409. doi:<a href="https://doi.org/10.3390/hearts2030031">10.3390/hearts2030031</a>'
  apa: 'Rubel, P., Fayn, J., Macfarlane, P. W., Pani, D., Schlögl, A., &#38; Värri,
    A. (2021). The history and challenges of SCP-ECG: The standard communication protocol
    for computer-assisted electrocardiography. <i>Hearts</i>. MDPI. <a href="https://doi.org/10.3390/hearts2030031">https://doi.org/10.3390/hearts2030031</a>'
  chicago: 'Rubel, Paul, Jocelyne Fayn, Peter W. Macfarlane, Danilo Pani, Alois Schlögl,
    and Alpo Värri. “The History and Challenges of SCP-ECG: The Standard Communication
    Protocol for Computer-Assisted Electrocardiography.” <i>Hearts</i>. MDPI, 2021.
    <a href="https://doi.org/10.3390/hearts2030031">https://doi.org/10.3390/hearts2030031</a>.'
  ieee: 'P. Rubel, J. Fayn, P. W. Macfarlane, D. Pani, A. Schlögl, and A. Värri, “The
    history and challenges of SCP-ECG: The standard communication protocol for computer-assisted
    electrocardiography,” <i>Hearts</i>, vol. 2, no. 3. MDPI, pp. 384–409, 2021.'
  ista: 'Rubel P, Fayn J, Macfarlane PW, Pani D, Schlögl A, Värri A. 2021. The history
    and challenges of SCP-ECG: The standard communication protocol for computer-assisted
    electrocardiography. Hearts. 2(3), 384–409.'
  mla: 'Rubel, Paul, et al. “The History and Challenges of SCP-ECG: The Standard Communication
    Protocol for Computer-Assisted Electrocardiography.” <i>Hearts</i>, vol. 2, no.
    3, MDPI, 2021, pp. 384–409, doi:<a href="https://doi.org/10.3390/hearts2030031">10.3390/hearts2030031</a>.'
  short: P. Rubel, J. Fayn, P.W. Macfarlane, D. Pani, A. Schlögl, A. Värri, Hearts
    2 (2021) 384–409.
date_created: 2024-04-03T09:03:31Z
date_published: 2021-08-24T00:00:00Z
date_updated: 2024-04-09T06:51:50Z
day: '24'
ddc:
- '610'
department:
- _id: ScienComp
doi: 10.3390/hearts2030031
file:
- access_level: open_access
  checksum: f67142b1e1e8ca5cd7a6a6798f46375e
  content_type: application/pdf
  creator: dernst
  date_created: 2024-04-09T06:49:47Z
  date_updated: 2024-04-09T06:49:47Z
  file_id: '15302'
  file_name: 2021_Hearts_Rubel.pdf
  file_size: 3539897
  relation: main_file
  success: 1
file_date_updated: 2024-04-09T06:49:47Z
has_accepted_license: '1'
intvolume: '         2'
issue: '3'
keyword:
- General Medicine
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 384-409
publication: Hearts
publication_identifier:
  issn:
  - 2673-3846
publication_status: published
publisher: MDPI
quality_controlled: '1'
status: public
title: 'The history and challenges of SCP-ECG: The standard communication protocol
  for computer-assisted electrocardiography'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2
year: '2021'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '19472'
abstract:
- lang: eng
  text: The forebrain hemispheres are predominantly separated during embryogenesis
    by the interhemispheric fissure (IHF). Radial astroglia remodel the IHF to form
    a continuous substrate between the hemispheres for midline crossing of the corpus
    callosum (CC) and hippocampal commissure (HC). Deleted in colorectal carcinoma
    (DCC) and netrin 1 (NTN1) are molecules that have an evolutionarily conserved
    function in commissural axon guidance. The CC and HC are absent in <jats:italic>Dcc</jats:italic>
    and <jats:italic>Ntn1</jats:italic> knockout mice, while other commissures are
    only partially affected, suggesting an additional aetiology in forebrain commissure
    formation. Here, we find that these molecules play a critical role in regulating
    astroglial development and IHF remodelling during CC and HC formation. Human subjects
    with <jats:italic>DCC</jats:italic> mutations display disrupted IHF remodelling
    associated with CC and HC malformations. Thus, axon guidance molecules such as
    DCC and NTN1 first regulate the formation of a midline substrate for dorsal commissures
    prior to their role in regulating axonal growth and guidance across it.
article_number: '61769'
article_processing_charge: Yes
article_type: original
author:
- first_name: Laura
  full_name: Morcom, Laura
  last_name: Morcom
- first_name: Ilan
  full_name: Gobius, Ilan
  last_name: Gobius
- first_name: Ashley PL
  full_name: Marsh, Ashley PL
  last_name: Marsh
- first_name: Rodrigo
  full_name: Suárez, Rodrigo
  last_name: Suárez
- first_name: Jonathan WC
  full_name: Lim, Jonathan WC
  last_name: Lim
- first_name: Caitlin
  full_name: Bridges, Caitlin
  last_name: Bridges
- first_name: Yunan
  full_name: Ye, Yunan
  last_name: Ye
- first_name: Laura R
  full_name: Fenlon, Laura R
  last_name: Fenlon
- first_name: Yvrick
  full_name: Zagar, Yvrick
  last_name: Zagar
- first_name: Amelia May Barnett
  full_name: Douglass, Amelia May Barnett
  id: de5f6fda-80fb-11ef-996f-a8c4ecd8e289
  last_name: Douglass
  orcid: 0000-0001-5398-6473
- first_name: Amber-Lee S
  full_name: Donahoo, Amber-Lee S
  last_name: Donahoo
- first_name: Thomas
  full_name: Fothergill, Thomas
  last_name: Fothergill
- first_name: Samreen
  full_name: Shaikh, Samreen
  last_name: Shaikh
- first_name: Peter
  full_name: Kozulin, Peter
  last_name: Kozulin
- first_name: Timothy J
  full_name: Edwards, Timothy J
  last_name: Edwards
- first_name: Helen M
  full_name: Cooper, Helen M
  last_name: Cooper
- first_name: Elliott H
  full_name: Sherr, Elliott H
  last_name: Sherr
- first_name: Alain
  full_name: Chédotal, Alain
  last_name: Chédotal
- first_name: Richard J
  full_name: Leventer, Richard J
  last_name: Leventer
- first_name: Paul J
  full_name: Lockhart, Paul J
  last_name: Lockhart
- first_name: Linda J
  full_name: Richards, Linda J
  last_name: Richards
citation:
  ama: Morcom L, Gobius I, Marsh AP, et al. DCC regulates astroglial development essential
    for telencephalic morphogenesis and corpus callosum formation. <i>eLife</i>. 2021;10.
    doi:<a href="https://doi.org/10.7554/elife.61769">10.7554/elife.61769</a>
  apa: Morcom, L., Gobius, I., Marsh, A. P., Suárez, R., Lim, J. W., Bridges, C.,
    … Richards, L. J. (2021). DCC regulates astroglial development essential for telencephalic
    morphogenesis and corpus callosum formation. <i>ELife</i>. eLife Sciences Publications.
    <a href="https://doi.org/10.7554/elife.61769">https://doi.org/10.7554/elife.61769</a>
  chicago: Morcom, Laura, Ilan Gobius, Ashley PL Marsh, Rodrigo Suárez, Jonathan WC
    Lim, Caitlin Bridges, Yunan Ye, et al. “DCC Regulates Astroglial Development Essential
    for Telencephalic Morphogenesis and Corpus Callosum Formation.” <i>ELife</i>.
    eLife Sciences Publications, 2021. <a href="https://doi.org/10.7554/elife.61769">https://doi.org/10.7554/elife.61769</a>.
  ieee: L. Morcom <i>et al.</i>, “DCC regulates astroglial development essential for
    telencephalic morphogenesis and corpus callosum formation,” <i>eLife</i>, vol.
    10. eLife Sciences Publications, 2021.
  ista: Morcom L, Gobius I, Marsh AP, Suárez R, Lim JW, Bridges C, Ye Y, Fenlon LR,
    Zagar Y, Douglass AM, Donahoo A-LS, Fothergill T, Shaikh S, Kozulin P, Edwards
    TJ, Cooper HM, Sherr EH, Chédotal A, Leventer RJ, Lockhart PJ, Richards LJ. 2021.
    DCC regulates astroglial development essential for telencephalic morphogenesis
    and corpus callosum formation. eLife. 10, 61769.
  mla: Morcom, Laura, et al. “DCC Regulates Astroglial Development Essential for Telencephalic
    Morphogenesis and Corpus Callosum Formation.” <i>ELife</i>, vol. 10, 61769, eLife
    Sciences Publications, 2021, doi:<a href="https://doi.org/10.7554/elife.61769">10.7554/elife.61769</a>.
  short: L. Morcom, I. Gobius, A.P. Marsh, R. Suárez, J.W. Lim, C. Bridges, Y. Ye,
    L.R. Fenlon, Y. Zagar, A.M. Douglass, A.-L.S. Donahoo, T. Fothergill, S. Shaikh,
    P. Kozulin, T.J. Edwards, H.M. Cooper, E.H. Sherr, A. Chédotal, R.J. Leventer,
    P.J. Lockhart, L.J. Richards, ELife 10 (2021).
date_created: 2025-04-03T12:29:29Z
date_published: 2021-04-19T00:00:00Z
date_updated: 2025-07-10T11:51:41Z
day: '19'
doi: 10.7554/elife.61769
extern: '1'
external_id:
  pmid:
  - '33871356'
has_accepted_license: '1'
intvolume: '        10'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.7554/eLife.61769
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
publication: eLife
publication_identifier:
  eissn:
  - 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: DCC regulates astroglial development essential for telencephalic morphogenesis
  and corpus callosum formation
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '2021'
...
---
OA_place: publisher
OA_type: hybrid
_id: '19489'
abstract:
- lang: eng
  text: "Let K be a cyclic number field of odd degree over \r\n\U0001D444 with odd
    narrow class number, such that 2 is inert in \U0001D43E/\U0001D444. We define
    a family of number fields {\U0001D43E(\U0001D45D)}\U0001D45D, depending on K and
    indexed by the rational primes p that split completely in \U0001D43E/\U0001D444,
    in which p is always ramified of degree 2. Conditional on a standard conjecture
    on short character sums, the density of such rational primes p that exhibit one
    of two possible ramified factorizations in \U0001D43E(\U0001D45D)/\U0001D444 is
    strictly between 0 and 1 and is given explicitly as a formula in terms of the
    degree of the extension \U0001D43E/\U0001D444. Our results are unconditional in
    the cubic case. Our proof relies on a detailed study of the joint distribution
    of spins of prime ideals."
article_number: '1'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Yik Tung
  full_name: Chan, Yik Tung
  id: c4c0afc8-9262-11ed-9231-d8b0bc743af1
  last_name: Chan
  orcid: 0000-0001-8467-4106
- first_name: Christine
  full_name: McMeekin, Christine
  last_name: McMeekin
- first_name: Djordjo
  full_name: Milovic, Djordjo
  last_name: Milovic
citation:
  ama: Chan S, McMeekin C, Milovic D. A density of ramified primes. <i>Research in
    Number Theory</i>. 2021;8. doi:<a href="https://doi.org/10.1007/s40993-021-00295-5">10.1007/s40993-021-00295-5</a>
  apa: Chan, S., McMeekin, C., &#38; Milovic, D. (2021). A density of ramified primes.
    <i>Research in Number Theory</i>. Springer Nature. <a href="https://doi.org/10.1007/s40993-021-00295-5">https://doi.org/10.1007/s40993-021-00295-5</a>
  chicago: Chan, Stephanie, Christine McMeekin, and Djordjo Milovic. “A Density of
    Ramified Primes.” <i>Research in Number Theory</i>. Springer Nature, 2021. <a
    href="https://doi.org/10.1007/s40993-021-00295-5">https://doi.org/10.1007/s40993-021-00295-5</a>.
  ieee: S. Chan, C. McMeekin, and D. Milovic, “A density of ramified primes,” <i>Research
    in Number Theory</i>, vol. 8. Springer Nature, 2021.
  ista: Chan S, McMeekin C, Milovic D. 2021. A density of ramified primes. Research
    in Number Theory. 8, 1.
  mla: Chan, Stephanie, et al. “A Density of Ramified Primes.” <i>Research in Number
    Theory</i>, vol. 8, 1, Springer Nature, 2021, doi:<a href="https://doi.org/10.1007/s40993-021-00295-5">10.1007/s40993-021-00295-5</a>.
  short: S. Chan, C. McMeekin, D. Milovic, Research in Number Theory 8 (2021).
date_created: 2025-04-05T10:50:51Z
date_published: 2021-11-15T00:00:00Z
date_updated: 2025-07-10T11:51:46Z
day: '15'
ddc:
- '510'
doi: 10.1007/s40993-021-00295-5
extern: '1'
external_id:
  arxiv:
  - '2005.10188'
has_accepted_license: '1'
intvolume: '         8'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1007/s40993-021-00295-5
month: '11'
oa: 1
oa_version: Published Version
publication: Research in Number Theory
publication_identifier:
  eissn:
  - 2363-9555
  issn:
  - 2522-0160
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: A density of ramified primes
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2021'
...
---
OA_place: repository
OA_type: green
_id: '19492'
abstract:
- lang: eng
  text: Kuroda’s formula relates the class number of a multiquadratic number field
    K to the class numbers of its quadratic subfields ki. A key component in this
    formula is the unit group index (math formular). We study how Q(K) behaves on
    average in certain natural families of totally real biquadratic fields K parametrized
    by prime numbers.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Yik Tung
  full_name: Chan, Yik Tung
  id: c4c0afc8-9262-11ed-9231-d8b0bc743af1
  last_name: Chan
  orcid: 0000-0001-8467-4106
- first_name: Djordjo
  full_name: Milovic, Djordjo
  last_name: Milovic
citation:
  ama: Chan S, Milovic D. Kuroda’s formula and arithmetic statistics. <i>Mathematische
    Zeitschrift</i>. 2021;300(2):1509-1527. doi:<a href="https://doi.org/10.1007/s00209-021-02823-6">10.1007/s00209-021-02823-6</a>
  apa: Chan, S., &#38; Milovic, D. (2021). Kuroda’s formula and arithmetic statistics.
    <i>Mathematische Zeitschrift</i>. Springer Nature. <a href="https://doi.org/10.1007/s00209-021-02823-6">https://doi.org/10.1007/s00209-021-02823-6</a>
  chicago: Chan, Stephanie, and Djordjo Milovic. “Kuroda’s Formula and Arithmetic
    Statistics.” <i>Mathematische Zeitschrift</i>. Springer Nature, 2021. <a href="https://doi.org/10.1007/s00209-021-02823-6">https://doi.org/10.1007/s00209-021-02823-6</a>.
  ieee: S. Chan and D. Milovic, “Kuroda’s formula and arithmetic statistics,” <i>Mathematische
    Zeitschrift</i>, vol. 300, no. 2. Springer Nature, pp. 1509–1527, 2021.
  ista: Chan S, Milovic D. 2021. Kuroda’s formula and arithmetic statistics. Mathematische
    Zeitschrift. 300(2), 1509–1527.
  mla: Chan, Stephanie, and Djordjo Milovic. “Kuroda’s Formula and Arithmetic Statistics.”
    <i>Mathematische Zeitschrift</i>, vol. 300, no. 2, Springer Nature, 2021, pp.
    1509–27, doi:<a href="https://doi.org/10.1007/s00209-021-02823-6">10.1007/s00209-021-02823-6</a>.
  short: S. Chan, D. Milovic, Mathematische Zeitschrift 300 (2021) 1509–1527.
date_created: 2025-04-05T10:51:04Z
date_published: 2021-08-17T00:00:00Z
date_updated: 2025-07-10T11:51:48Z
day: '17'
doi: 10.1007/s00209-021-02823-6
extern: '1'
external_id:
  arxiv:
  - '1905.09745'
intvolume: '       300'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.1905.09745
month: '08'
oa: 1
oa_version: Preprint
page: 1509-1527
publication: Mathematische Zeitschrift
publication_identifier:
  eissn:
  - 1432-1823
  issn:
  - 0025-5874
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Kuroda’s formula and arithmetic statistics
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 300
year: '2021'
...
---
OA_place: repository
OA_type: green
_id: '19909'
abstract:
- lang: eng
  text: Most water in the Universe may be superionic, and its thermodynamic and transport
    properties are crucial for planetary science but difficult to probe experimentally
    or theoretically. We use machine learning and free-energy methods to overcome
    the limitations of quantum mechanical simulations and characterize hydrogen diffusion,
    superionic transitions and phase behaviours of water at extreme conditions. We
    predict that close-packed superionic phases, which have a fraction of mixed stacking
    for finite systems, are stable over a wide temperature and pressure range, whereas
    a body-centred cubic superionic phase is only thermodynamically stable in a small
    window but is kinetically favoured. Our phase boundaries, which are consistent
    with existing—albeit scarce—experimental observations, help resolve the fractions
    of insulating ice, different superionic phases and liquid water inside ice giants.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Bingqing
  full_name: Cheng, Bingqing
  id: cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9
  last_name: Cheng
  orcid: 0000-0002-3584-9632
- first_name: Mandy
  full_name: Bethkenhagen, Mandy
  last_name: Bethkenhagen
- first_name: Chris J.
  full_name: Pickard, Chris J.
  last_name: Pickard
- first_name: Sebastien
  full_name: Hamel, Sebastien
  last_name: Hamel
citation:
  ama: Cheng B, Bethkenhagen M, Pickard CJ, Hamel S. Phase behaviours of superionic
    water at planetary conditions. <i>Nature Physics</i>. 2021;17(11):1228-1232. doi:<a
    href="https://doi.org/10.1038/s41567-021-01334-9">10.1038/s41567-021-01334-9</a>
  apa: Cheng, B., Bethkenhagen, M., Pickard, C. J., &#38; Hamel, S. (2021). Phase
    behaviours of superionic water at planetary conditions. <i>Nature Physics</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41567-021-01334-9">https://doi.org/10.1038/s41567-021-01334-9</a>
  chicago: Cheng, Bingqing, Mandy Bethkenhagen, Chris J. Pickard, and Sebastien Hamel.
    “Phase Behaviours of Superionic Water at Planetary Conditions.” <i>Nature Physics</i>.
    Springer Nature, 2021. <a href="https://doi.org/10.1038/s41567-021-01334-9">https://doi.org/10.1038/s41567-021-01334-9</a>.
  ieee: B. Cheng, M. Bethkenhagen, C. J. Pickard, and S. Hamel, “Phase behaviours
    of superionic water at planetary conditions,” <i>Nature Physics</i>, vol. 17,
    no. 11. Springer Nature, pp. 1228–1232, 2021.
  ista: Cheng B, Bethkenhagen M, Pickard CJ, Hamel S. 2021. Phase behaviours of superionic
    water at planetary conditions. Nature Physics. 17(11), 1228–1232.
  mla: Cheng, Bingqing, et al. “Phase Behaviours of Superionic Water at Planetary
    Conditions.” <i>Nature Physics</i>, vol. 17, no. 11, Springer Nature, 2021, pp.
    1228–32, doi:<a href="https://doi.org/10.1038/s41567-021-01334-9">10.1038/s41567-021-01334-9</a>.
  short: B. Cheng, M. Bethkenhagen, C.J. Pickard, S. Hamel, Nature Physics 17 (2021)
    1228–1232.
date_created: 2025-06-26T11:36:36Z
date_published: 2021-11-01T00:00:00Z
date_updated: 2025-06-26T11:49:07Z
day: '01'
doi: 10.1038/s41567-021-01334-9
extern: '1'
external_id:
  arxiv:
  - '2103.09035'
intvolume: '        17'
issue: '11'
language:
- iso: eng
month: '11'
oa_version: Preprint
page: 1228-1232
publication: Nature Physics
publication_identifier:
  eissn:
  - 1745-2481
  issn:
  - 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  record:
  - id: '9696'
    relation: earlier_version
    status: public
scopus_import: '1'
status: public
title: Phase behaviours of superionic water at planetary conditions
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2021'
...
---
OA_place: repository
OA_type: green
_id: '20619'
abstract:
- lang: eng
  text: The first author’s previous work established Solomon’s WDVV-type relations
    for Welschinger’s invariant curve counts in real symplectic fourfolds by lifting
    geometric relations over possibly unorientable morphisms. We apply her framework
    to obtain WDVV-style relations for the disk invariants of real symplectic sixfolds
    with some symmetry, in particular confirming Alcolado’s prediction for P^3 and
    extending it to other spaces. These relations reduce the computation of Welschinger’s
    invariants of many real symplectic sixfolds to invariants in small degrees and
    provide lower bounds for counts of real rational curves with positive-dimensional
    insertions in some cases. In the case of P^3, our lower bounds fit perfectly with
    Kollár’s vanishing results.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Xujia
  full_name: Chen, Xujia
  id: 968ad14a-fd86-11ee-a420-ea29715511a3
  last_name: Chen
- first_name: Aleksey
  full_name: Zinger, Aleksey
  last_name: Zinger
citation:
  ama: Chen X, Zinger A. WDVV-type relations for disk Gromov–Witten invariants in
    dimension 6. <i>Mathematische Annalen</i>. 2021;379(3-4):1231-1313. doi:<a href="https://doi.org/10.1007/s00208-020-02130-1">10.1007/s00208-020-02130-1</a>
  apa: Chen, X., &#38; Zinger, A. (2021). WDVV-type relations for disk Gromov–Witten
    invariants in dimension 6. <i>Mathematische Annalen</i>. Springer Nature. <a href="https://doi.org/10.1007/s00208-020-02130-1">https://doi.org/10.1007/s00208-020-02130-1</a>
  chicago: Chen, Xujia, and Aleksey Zinger. “WDVV-Type Relations for Disk Gromov–Witten
    Invariants in Dimension 6.” <i>Mathematische Annalen</i>. Springer Nature, 2021.
    <a href="https://doi.org/10.1007/s00208-020-02130-1">https://doi.org/10.1007/s00208-020-02130-1</a>.
  ieee: X. Chen and A. Zinger, “WDVV-type relations for disk Gromov–Witten invariants
    in dimension 6,” <i>Mathematische Annalen</i>, vol. 379, no. 3–4. Springer Nature,
    pp. 1231–1313, 2021.
  ista: Chen X, Zinger A. 2021. WDVV-type relations for disk Gromov–Witten invariants
    in dimension 6. Mathematische Annalen. 379(3–4), 1231–1313.
  mla: Chen, Xujia, and Aleksey Zinger. “WDVV-Type Relations for Disk Gromov–Witten
    Invariants in Dimension 6.” <i>Mathematische Annalen</i>, vol. 379, no. 3–4, Springer
    Nature, 2021, pp. 1231–313, doi:<a href="https://doi.org/10.1007/s00208-020-02130-1">10.1007/s00208-020-02130-1</a>.
  short: X. Chen, A. Zinger, Mathematische Annalen 379 (2021) 1231–1313.
date_created: 2025-11-10T08:41:40Z
date_published: 2021-01-25T00:00:00Z
date_updated: 2025-11-10T15:11:29Z
day: '25'
doi: 10.1007/s00208-020-02130-1
extern: '1'
external_id:
  arxiv:
  - '1904.04254'
intvolume: '       379'
issue: 3-4
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.1904.04254
month: '01'
oa: 1
oa_version: Preprint
page: 1231-1313
publication: Mathematische Annalen
publication_identifier:
  eissn:
  - 1432-1807
  issn:
  - 0025-5831
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: WDVV-type relations for disk Gromov–Witten invariants in dimension 6
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 379
year: '2021'
...
---
OA_place: repository
OA_type: green
_id: '20622'
abstract:
- lang: eng
  text: We first recall Solomon’s relations for Welschinger invariants counting real
    curves in real symplectic fourfolds and the Witten–Dijkgraaf–Verlinde–Verlinde
    (WDVV)-style relations for Welschinger invariants counting real curves in real
    symplectic sixfolds with some symmetry. We then explicitly demonstrate that, in
    some important cases (projective spaces with standard conjugations, real blowups
    of the projective plane, and two- and threefold products of the one-dimensional
    projective space with two involutions each), these relations provide complete
    recursions determining all Welschinger invariants from basic input. We include
    extensive tables of Welschinger invariants in low degrees obtained from these
    recursions with Mathematica. These invariants provide lower bounds for counts
    of real rational curves, including with curve insertions in smooth algebraic threefolds.
article_processing_charge: No
arxiv: 1
author:
- first_name: Xujia
  full_name: Chen, Xujia
  id: 968ad14a-fd86-11ee-a420-ea29715511a3
  last_name: Chen
- first_name: Aleksey
  full_name: Zinger, Aleksey
  last_name: Zinger
citation:
  ama: 'Chen X, Zinger A. WDVV-type relations for Welschinger’s invariants: Applications.
    <i>Kyoto Journal of Mathematics</i>. 61(2):339-376. doi:<a href="https://doi.org/10.1215/21562261-2021-0005">10.1215/21562261-2021-0005</a>'
  apa: 'Chen, X., &#38; Zinger, A. (n.d.). WDVV-type relations for Welschinger’s invariants:
    Applications. <i>Kyoto Journal of Mathematics</i>. Duke University Press. <a href="https://doi.org/10.1215/21562261-2021-0005">https://doi.org/10.1215/21562261-2021-0005</a>'
  chicago: 'Chen, Xujia, and Aleksey Zinger. “WDVV-Type Relations for Welschinger’s
    Invariants: Applications.” <i>Kyoto Journal of Mathematics</i>. Duke University
    Press, n.d. <a href="https://doi.org/10.1215/21562261-2021-0005">https://doi.org/10.1215/21562261-2021-0005</a>.'
  ieee: 'X. Chen and A. Zinger, “WDVV-type relations for Welschinger’s invariants:
    Applications,” <i>Kyoto Journal of Mathematics</i>, vol. 61, no. 2. Duke University
    Press, pp. 339–376.'
  ista: 'Chen X, Zinger A. WDVV-type relations for Welschinger’s invariants: Applications.
    Kyoto Journal of Mathematics. 61(2), 339–376.'
  mla: 'Chen, Xujia, and Aleksey Zinger. “WDVV-Type Relations for Welschinger’s Invariants:
    Applications.” <i>Kyoto Journal of Mathematics</i>, vol. 61, no. 2, Duke University
    Press, pp. 339–76, doi:<a href="https://doi.org/10.1215/21562261-2021-0005">10.1215/21562261-2021-0005</a>.'
  short: X. Chen, A. Zinger, Kyoto Journal of Mathematics 61 (n.d.) 339–376.
date_created: 2025-11-10T08:45:12Z
date_published: 2021-06-01T00:00:00Z
date_updated: 2025-11-10T15:13:58Z
day: '01'
doi: 10.1215/21562261-2021-0005
extern: '1'
external_id:
  arxiv:
  - '1809.08938'
intvolume: '        61'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.1809.08938
month: '06'
oa: 1
oa_version: Preprint
page: 339-376
publication: Kyoto Journal of Mathematics
publication_identifier:
  eissn:
  - 2154-3321
publication_status: submitted
publisher: Duke University Press
quality_controlled: '1'
status: public
title: 'WDVV-type relations for Welschinger''s invariants: Applications'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 61
year: '2021'
...
---
OA_place: publisher
OA_type: hybrid
_id: '20765'
abstract:
- lang: eng
  text: <p>A cascade Suzuki–Miyaura cross-coupling between two non-symmetrical coupling
    partners gave rise to 9,10-dihydrophenanthrenes with full site-selectivity. The
    choice of base was critical to facilitate the challenging coupling of the secondary
    boronate group.</p>
article_processing_charge: No
article_type: original
author:
- first_name: Suzanne
  full_name: Willems, Suzanne
  last_name: Willems
- first_name: Georgios
  full_name: Toupalas, Georgios
  last_name: Toupalas
- first_name: Julia
  full_name: Reisenbauer, Julia
  id: 51d862e9-36ee-11f0-86d3-8534c85a5496
  last_name: Reisenbauer
- first_name: Bill
  full_name: Morandi, Bill
  last_name: Morandi
citation:
  ama: Willems S, Toupalas G, Reisenbauer J, Morandi B. A site-selective and stereospecific
    cascade Suzuki–Miyaura annulation of alkyl 1,2-bisboronic esters and 2,2′-dihalo
    1,1′-biaryls. <i>Chemical Communications</i>. 2021;57(32):3909-3912. doi:<a href="https://doi.org/10.1039/d1cc00648g">10.1039/d1cc00648g</a>
  apa: Willems, S., Toupalas, G., Reisenbauer, J., &#38; Morandi, B. (2021). A site-selective
    and stereospecific cascade Suzuki–Miyaura annulation of alkyl 1,2-bisboronic esters
    and 2,2′-dihalo 1,1′-biaryls. <i>Chemical Communications</i>. Royal Society of
    Chemistry. <a href="https://doi.org/10.1039/d1cc00648g">https://doi.org/10.1039/d1cc00648g</a>
  chicago: Willems, Suzanne, Georgios Toupalas, Julia Reisenbauer, and Bill Morandi.
    “A Site-Selective and Stereospecific Cascade Suzuki–Miyaura Annulation of Alkyl
    1,2-Bisboronic Esters and 2,2′-Dihalo 1,1′-Biaryls.” <i>Chemical Communications</i>.
    Royal Society of Chemistry, 2021. <a href="https://doi.org/10.1039/d1cc00648g">https://doi.org/10.1039/d1cc00648g</a>.
  ieee: S. Willems, G. Toupalas, J. Reisenbauer, and B. Morandi, “A site-selective
    and stereospecific cascade Suzuki–Miyaura annulation of alkyl 1,2-bisboronic esters
    and 2,2′-dihalo 1,1′-biaryls,” <i>Chemical Communications</i>, vol. 57, no. 32.
    Royal Society of Chemistry, pp. 3909–3912, 2021.
  ista: Willems S, Toupalas G, Reisenbauer J, Morandi B. 2021. A site-selective and
    stereospecific cascade Suzuki–Miyaura annulation of alkyl 1,2-bisboronic esters
    and 2,2′-dihalo 1,1′-biaryls. Chemical Communications. 57(32), 3909–3912.
  mla: Willems, Suzanne, et al. “A Site-Selective and Stereospecific Cascade Suzuki–Miyaura
    Annulation of Alkyl 1,2-Bisboronic Esters and 2,2′-Dihalo 1,1′-Biaryls.” <i>Chemical
    Communications</i>, vol. 57, no. 32, Royal Society of Chemistry, 2021, pp. 3909–12,
    doi:<a href="https://doi.org/10.1039/d1cc00648g">10.1039/d1cc00648g</a>.
  short: S. Willems, G. Toupalas, J. Reisenbauer, B. Morandi, Chemical Communications
    57 (2021) 3909–3912.
date_created: 2025-12-09T14:25:17Z
date_published: 2021-03-15T00:00:00Z
date_updated: 2025-12-16T12:06:53Z
day: '15'
ddc:
- '540'
doi: 10.1039/d1cc00648g
extern: '1'
external_id:
  pmid:
  - '33871510'
has_accepted_license: '1'
intvolume: '        57'
issue: '32'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/3.0/
main_file_link:
- open_access: '1'
  url: "DOI\thttps://doi.org/10.1039/D1CC00648G"
month: '03'
oa: 1
oa_version: Published Version
page: 3909-3912
pmid: 1
publication: Chemical Communications
publication_identifier:
  eissn:
  - 1364-548X
  issn:
  - 1359-7345
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: A site-selective and stereospecific cascade Suzuki–Miyaura annulation of alkyl
  1,2-bisboronic esters and 2,2′-dihalo 1,1′-biaryls
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/3.0/legalcode
  name: Creative Commons Attribution 3.0 Unported (CC BY 3.0)
  short: CC BY (3.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 57
year: '2021'
...
---
OA_place: publisher
_id: '10007'
abstract:
- lang: eng
  text: The present thesis is concerned with the derivation of weak-strong uniqueness
    principles for curvature driven interface evolution problems not satisfying a
    comparison principle. The specific examples being treated are two-phase Navier-Stokes
    flow with surface tension, modeling the evolution of two incompressible, viscous
    and immiscible fluids separated by a sharp interface, and multiphase mean curvature
    flow, which serves as an idealized model for the motion of grain boundaries in
    an annealing polycrystalline material. Our main results - obtained in joint works
    with Julian Fischer, Tim Laux and Theresa M. Simon - state that prior to the formation
    of geometric singularities due to topology changes, the weak solution concept
    of Abels (Interfaces Free Bound. 9, 2007) to two-phase Navier-Stokes flow with
    surface tension and the weak solution concept of Laux and Otto (Calc. Var. Partial
    Differential Equations 55, 2016) to multiphase mean curvature flow (for networks
    in R^2 or double bubbles in R^3) represents the unique solution to these interface
    evolution problems within the class of classical solutions, respectively. To the
    best of the author's knowledge, for interface evolution problems not admitting
    a geometric comparison principle the derivation of a weak-strong uniqueness principle
    represented an open problem, so that the works contained in the present thesis
    constitute the first positive results in this direction. The key ingredient of
    our approach consists of the introduction of a novel concept of relative entropies
    for a class of curvature driven interface evolution problems, for which the associated
    energy contains an interfacial contribution being proportional to the surface
    area of the evolving (network of) interface(s). The interfacial part of the relative
    entropy gives sufficient control on the interface error between a weak and a classical
    solution, and its time evolution can be computed, at least in principle, for any
    energy dissipating weak solution concept. A resulting stability estimate for the
    relative entropy essentially entails the above mentioned weak-strong uniqueness
    principles. The present thesis contains a detailed introduction to our relative
    entropy approach, which in particular highlights potential applications to other
    problems in curvature driven interface evolution not treated in this thesis.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Sebastian
  full_name: Hensel, Sebastian
  id: 4D23B7DA-F248-11E8-B48F-1D18A9856A87
  last_name: Hensel
  orcid: 0000-0001-7252-8072
citation:
  ama: 'Hensel S. Curvature driven interface evolution: Uniqueness properties of weak
    solution concepts. 2021. doi:<a href="https://doi.org/10.15479/at:ista:10007">10.15479/at:ista:10007</a>'
  apa: 'Hensel, S. (2021). <i>Curvature driven interface evolution: Uniqueness properties
    of weak solution concepts</i>. Institute of Science and Technology Austria. <a
    href="https://doi.org/10.15479/at:ista:10007">https://doi.org/10.15479/at:ista:10007</a>'
  chicago: 'Hensel, Sebastian. “Curvature Driven Interface Evolution: Uniqueness Properties
    of Weak Solution Concepts.” Institute of Science and Technology Austria, 2021.
    <a href="https://doi.org/10.15479/at:ista:10007">https://doi.org/10.15479/at:ista:10007</a>.'
  ieee: 'S. Hensel, “Curvature driven interface evolution: Uniqueness properties of
    weak solution concepts,” Institute of Science and Technology Austria, 2021.'
  ista: 'Hensel S. 2021. Curvature driven interface evolution: Uniqueness properties
    of weak solution concepts. Institute of Science and Technology Austria.'
  mla: 'Hensel, Sebastian. <i>Curvature Driven Interface Evolution: Uniqueness Properties
    of Weak Solution Concepts</i>. Institute of Science and Technology Austria, 2021,
    doi:<a href="https://doi.org/10.15479/at:ista:10007">10.15479/at:ista:10007</a>.'
  short: 'S. Hensel, Curvature Driven Interface Evolution: Uniqueness Properties of
    Weak Solution Concepts, Institute of Science and Technology Austria, 2021.'
corr_author: '1'
date_created: 2021-09-13T11:12:34Z
date_published: 2021-09-14T00:00:00Z
date_updated: 2026-04-08T07:01:01Z
day: '14'
ddc:
- '515'
degree_awarded: PhD
department:
- _id: GradSch
- _id: JuFi
doi: 10.15479/at:ista:10007
ec_funded: 1
file:
- access_level: closed
  checksum: c8475faaf0b680b4971f638f1db16347
  content_type: application/x-zip-compressed
  creator: shensel
  date_created: 2021-09-13T11:03:24Z
  date_updated: 2021-09-15T14:37:30Z
  file_id: '10008'
  file_name: thesis_final_Hensel.zip
  file_size: 15022154
  relation: source_file
- access_level: open_access
  checksum: 1a609937aa5275452822f45f2da17f07
  content_type: application/pdf
  creator: shensel
  date_created: 2021-09-13T14:18:56Z
  date_updated: 2021-09-14T09:52:47Z
  file_id: '10014'
  file_name: thesis_final_Hensel.pdf
  file_size: 6583638
  relation: main_file
file_date_updated: 2021-09-15T14:37:30Z
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '300'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
- _id: 0aa76401-070f-11eb-9043-b5bb049fa26d
  call_identifier: H2020
  grant_number: '948819'
  name: Bridging Scales in Random Materials
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '10012'
    relation: part_of_dissertation
    status: public
  - id: '10013'
    relation: part_of_dissertation
    status: public
  - id: '7489'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Julian L
  full_name: Fischer, Julian L
  id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
  last_name: Fischer
  orcid: 0000-0002-0479-558X
title: 'Curvature driven interface evolution: Uniqueness properties of weak solution
  concepts'
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2021'
...
---
_id: '10013'
abstract:
- lang: eng
  text: We derive a weak-strong uniqueness principle for BV solutions to multiphase
    mean curvature flow of triple line clusters in three dimensions. Our proof is
    based on the explicit construction of a gradient-flow calibration in the sense
    of the recent work of Fischer et al. [arXiv:2003.05478] for any such cluster.
    This extends the two-dimensional construction to the three-dimensional case of
    surfaces meeting along triple junctions.
acknowledgement: This project has received funding from the European Research Council
  (ERC) under the European Union’s Horizon 2020 research and innovation programme
  (grant agreement No 948819), and from the Deutsche Forschungsgemeinschaft (DFG,
  German Research Foundation) under Germany’s Excellence Strategy – EXC-2047/1 – 390685813.
article_number: '2108.01733'
article_processing_charge: No
arxiv: 1
author:
- first_name: Sebastian
  full_name: Hensel, Sebastian
  id: 4D23B7DA-F248-11E8-B48F-1D18A9856A87
  last_name: Hensel
  orcid: 0000-0001-7252-8072
- first_name: Tim
  full_name: Laux, Tim
  last_name: Laux
citation:
  ama: Hensel S, Laux T. Weak-strong uniqueness for the mean curvature flow of double
    bubbles. <i>arXiv</i>. doi:<a href="https://doi.org/10.48550/arXiv.2108.01733">10.48550/arXiv.2108.01733</a>
  apa: Hensel, S., &#38; Laux, T. (n.d.). Weak-strong uniqueness for the mean curvature
    flow of double bubbles. <i>arXiv</i>. <a href="https://doi.org/10.48550/arXiv.2108.01733">https://doi.org/10.48550/arXiv.2108.01733</a>
  chicago: Hensel, Sebastian, and Tim Laux. “Weak-Strong Uniqueness for the Mean Curvature
    Flow of Double Bubbles.” <i>ArXiv</i>, n.d. <a href="https://doi.org/10.48550/arXiv.2108.01733">https://doi.org/10.48550/arXiv.2108.01733</a>.
  ieee: S. Hensel and T. Laux, “Weak-strong uniqueness for the mean curvature flow
    of double bubbles,” <i>arXiv</i>. .
  ista: Hensel S, Laux T. Weak-strong uniqueness for the mean curvature flow of double
    bubbles. arXiv, 2108.01733.
  mla: Hensel, Sebastian, and Tim Laux. “Weak-Strong Uniqueness for the Mean Curvature
    Flow of Double Bubbles.” <i>ArXiv</i>, 2108.01733, doi:<a href="https://doi.org/10.48550/arXiv.2108.01733">10.48550/arXiv.2108.01733</a>.
  short: S. Hensel, T. Laux, ArXiv (n.d.).
corr_author: '1'
date_created: 2021-09-13T12:17:11Z
date_published: 2021-08-03T00:00:00Z
date_updated: 2026-04-08T07:01:01Z
day: '03'
department:
- _id: JuFi
doi: 10.48550/arXiv.2108.01733
ec_funded: 1
external_id:
  arxiv:
  - '2108.01733'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2108.01733
month: '08'
oa: 1
oa_version: Preprint
project:
- _id: 0aa76401-070f-11eb-9043-b5bb049fa26d
  call_identifier: H2020
  grant_number: '948819'
  name: Bridging Scales in Random Materials
publication: arXiv
publication_status: draft
related_material:
  record:
  - id: '13043'
    relation: later_version
    status: public
  - id: '10007'
    relation: dissertation_contains
    status: public
status: public
title: Weak-strong uniqueness for the mean curvature flow of double bubbles
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '10024'
abstract:
- lang: eng
  text: In this paper, we introduce a random environment for the exclusion process
    in  obtained by assigning a maximal occupancy to each site. This maximal occupancy
    is allowed to randomly vary among sites, and partial exclusion occurs. Under the
    assumption of ergodicity under translation and uniform ellipticity of the environment,
    we derive a quenched hydrodynamic limit in path space by strengthening the mild
    solution approach initiated in Nagy (2002) and Faggionato (2007). To this purpose,
    we prove, employing the technology developed for the random conductance model,
    a homogenization result in the form of an arbitrary starting point quenched invariance
    principle for a single particle in the same environment, which is a result of
    independent interest. The self-duality property of the partial exclusion process
    allows us to transfer this homogenization result to the particle system and, then,
    apply the tightness criterion in Redig et al. (2020).
acknowledgement: The authors would like to thank Marek Biskup and Alberto Chiarini
  for useful suggestions and  Cristian  Giardina,  Frank  den  Hollander  and  Shubhamoy  Nandan  for  inspiring  discussions.  S.F.  acknowledges  Simona  Villa  for  her  help  in  creating  the  picture.  Furthermore,
  the  authors  thank  two  anonymous  referees  for  the  careful  reading  of  the  manuscript.  S.F.
  acknowledges  financial  support  from  NWO,  The  Netherlands  via  the  grant  TOP1.17.019.
  F.S.  acknowledges  financial  support  from  NWO  via  the  TOP1  grant  613.001.552  as  well  as
  funding from the European Union’s Horizon 2020 research and innovation programme
  under the Marie-Skłodowska-Curie grant agreement No. 754411.
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Simone
  full_name: Floreani, Simone
  last_name: Floreani
- first_name: Frank
  full_name: Redig, Frank
  last_name: Redig
- first_name: Federico
  full_name: Sau, Federico
  id: E1836206-9F16-11E9-8814-AEFDE5697425
  last_name: Sau
citation:
  ama: Floreani S, Redig F, Sau F. Hydrodynamics for the partial exclusion process
    in random environment. <i>Stochastic Processes and their Applications</i>. 2021;142:124-158.
    doi:<a href="https://doi.org/10.1016/j.spa.2021.08.006">10.1016/j.spa.2021.08.006</a>
  apa: Floreani, S., Redig, F., &#38; Sau, F. (2021). Hydrodynamics for the partial
    exclusion process in random environment. <i>Stochastic Processes and Their Applications</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.spa.2021.08.006">https://doi.org/10.1016/j.spa.2021.08.006</a>
  chicago: Floreani, Simone, Frank Redig, and Federico Sau. “Hydrodynamics for the
    Partial Exclusion Process in Random Environment.” <i>Stochastic Processes and
    Their Applications</i>. Elsevier, 2021. <a href="https://doi.org/10.1016/j.spa.2021.08.006">https://doi.org/10.1016/j.spa.2021.08.006</a>.
  ieee: S. Floreani, F. Redig, and F. Sau, “Hydrodynamics for the partial exclusion
    process in random environment,” <i>Stochastic Processes and their Applications</i>,
    vol. 142. Elsevier, pp. 124–158, 2021.
  ista: Floreani S, Redig F, Sau F. 2021. Hydrodynamics for the partial exclusion
    process in random environment. Stochastic Processes and their Applications. 142,
    124–158.
  mla: Floreani, Simone, et al. “Hydrodynamics for the Partial Exclusion Process in
    Random Environment.” <i>Stochastic Processes and Their Applications</i>, vol.
    142, Elsevier, 2021, pp. 124–58, doi:<a href="https://doi.org/10.1016/j.spa.2021.08.006">10.1016/j.spa.2021.08.006</a>.
  short: S. Floreani, F. Redig, F. Sau, Stochastic Processes and Their Applications
    142 (2021) 124–158.
date_created: 2021-09-19T22:01:25Z
date_published: 2021-08-27T00:00:00Z
date_updated: 2025-04-14T07:43:46Z
day: '27'
ddc:
- '519'
department:
- _id: JaMa
doi: 10.1016/j.spa.2021.08.006
ec_funded: 1
external_id:
  arxiv:
  - '1911.12564'
  isi:
  - '000697748500005'
file:
- access_level: open_access
  checksum: 56768c553d7218ee5714902ffec90ec4
  content_type: application/pdf
  creator: dernst
  date_created: 2022-05-13T07:55:50Z
  date_updated: 2022-05-13T07:55:50Z
  file_id: '11370'
  file_name: 2021_StochasticProcessesAppl_Floreani.pdf
  file_size: 2115791
  relation: main_file
  success: 1
file_date_updated: 2022-05-13T07:55:50Z
has_accepted_license: '1'
intvolume: '       142'
isi: 1
keyword:
- hydrodynamic limit
- random environment
- random conductance model
- arbitrary starting point quenched invariance principle
- duality
- mild solution
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 124-158
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: Stochastic Processes and their Applications
publication_identifier:
  issn:
  - 0304-4149
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Hydrodynamics for the partial exclusion process in random environment
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 142
year: '2021'
...
---
_id: '10025'
abstract:
- lang: eng
  text: Ferromagnetism is most common in transition metal compounds but may also arise
    in low-density two-dimensional electron systems, with signatures observed in silicon,
    III-V semiconductor systems, and graphene moiré heterostructures. Here we show
    that gate-tuned van Hove singularities in rhombohedral trilayer graphene drive
    the spontaneous ferromagnetic polarization of the electron system into one or
    more spin- and valley flavors. Using capacitance measurements on graphite-gated
    van der Waals heterostructures, we find a cascade of density- and electronic displacement
    field tuned phase transitions marked by negative electronic compressibility. The
    transitions define the boundaries between phases where quantum oscillations have
    either four-fold, two-fold, or one-fold degeneracy, associated with a spin and
    valley degenerate normal metal, spin-polarized `half-metal', and spin and valley
    polarized `quarter metal', respectively. For electron doping, the salient features
    are well captured by a phenomenological Stoner model with a valley-anisotropic
    Hund's coupling, likely arising from interactions at the lattice scale. For hole
    filling, we observe a richer phase diagram featuring a delicate interplay of broken
    symmetries and transitions in the Fermi surface topology. Finally, by rotational
    alignment of a hexagonal boron nitride substrate to induce a moiré superlattice,
    we find that the superlattice perturbs the preexisting isospin order only weakly,
    leaving the basic phase diagram intact while catalyzing the formation of topologically
    nontrivial gapped states whenever itinerant half- or quarter metal states occur
    at half- or quarter superlattice band filling. Our results show that rhombohedral
    trilayer graphene is an ideal platform for well-controlled tests of many-body
    theory and reveal magnetism in moiré materials to be fundamentally itinerant in
    nature.
acknowledgement: "The authors acknowledge discussions with A. Macdonald, L. Fu, F.
  Wang and M. Zaletel. AFY acknowledges support of the National Science Foundation
  under DMR1654186, and the Gordon and Betty Moore Foundation under award GBMF9471.
  The authors acknowledge the use of the research facilities within the California
  NanoSystems Institute, supported by the University of California, Santa Barbara
  and the University of California, Office of the President.\r\nK.W. and T.T. acknowledge
  support from the Elemental Strategy Initiative conducted by the MEXT, Japan, Grant
  Number JPMXP0112101001 and JSPS KAKENHI, Grant Number JP20H00354. EB and TH were
  supported by the European Research Council (ERC) under grant HQMAT (Grant Agreement
  No. 817799). A.G. acknowledges support by the European Unions Horizon 2020 research
  and innovation program under the Marie Sklodowska-Curie Grant Agreement\r\nNo. 754411.\r\n"
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Haoxin
  full_name: Zhou, Haoxin
  last_name: Zhou
- first_name: Tian
  full_name: Xie, Tian
  last_name: Xie
- first_name: Areg
  full_name: Ghazaryan, Areg
  id: 4AF46FD6-F248-11E8-B48F-1D18A9856A87
  last_name: Ghazaryan
  orcid: 0000-0001-9666-3543
- first_name: Tobias
  full_name: Holder, Tobias
  last_name: Holder
- first_name: James R.
  full_name: Ehrets, James R.
  last_name: Ehrets
- first_name: Eric M.
  full_name: Spanton, Eric M.
  last_name: Spanton
- first_name: Takashi
  full_name: Taniguchi, Takashi
  last_name: Taniguchi
- first_name: Kenji
  full_name: Watanabe, Kenji
  last_name: Watanabe
- first_name: Erez
  full_name: Berg, Erez
  last_name: Berg
- first_name: Maksym
  full_name: Serbyn, Maksym
  id: 47809E7E-F248-11E8-B48F-1D18A9856A87
  last_name: Serbyn
  orcid: 0000-0002-2399-5827
- first_name: Andrea F.
  full_name: Young, Andrea F.
  last_name: Young
citation:
  ama: Zhou H, Xie T, Ghazaryan A, et al. Half and quarter metals in rhombohedral
    trilayer graphene. <i>Nature</i>. 2021. doi:<a href="https://doi.org/10.1038/s41586-021-03938-w">10.1038/s41586-021-03938-w</a>
  apa: Zhou, H., Xie, T., Ghazaryan, A., Holder, T., Ehrets, J. R., Spanton, E. M.,
    … Young, A. F. (2021). Half and quarter metals in rhombohedral trilayer graphene.
    <i>Nature</i>. Springer Nature. <a href="https://doi.org/10.1038/s41586-021-03938-w">https://doi.org/10.1038/s41586-021-03938-w</a>
  chicago: Zhou, Haoxin, Tian Xie, Areg Ghazaryan, Tobias Holder, James R. Ehrets,
    Eric M. Spanton, Takashi Taniguchi, et al. “Half and Quarter Metals in Rhombohedral
    Trilayer Graphene.” <i>Nature</i>. Springer Nature, 2021. <a href="https://doi.org/10.1038/s41586-021-03938-w">https://doi.org/10.1038/s41586-021-03938-w</a>.
  ieee: H. Zhou <i>et al.</i>, “Half and quarter metals in rhombohedral trilayer graphene,”
    <i>Nature</i>. Springer Nature, 2021.
  ista: Zhou H, Xie T, Ghazaryan A, Holder T, Ehrets JR, Spanton EM, Taniguchi T,
    Watanabe K, Berg E, Serbyn M, Young AF. 2021. Half and quarter metals in rhombohedral
    trilayer graphene. Nature.
  mla: Zhou, Haoxin, et al. “Half and Quarter Metals in Rhombohedral Trilayer Graphene.”
    <i>Nature</i>, Springer Nature, 2021, doi:<a href="https://doi.org/10.1038/s41586-021-03938-w">10.1038/s41586-021-03938-w</a>.
  short: H. Zhou, T. Xie, A. Ghazaryan, T. Holder, J.R. Ehrets, E.M. Spanton, T. Taniguchi,
    K. Watanabe, E. Berg, M. Serbyn, A.F. Young, Nature (2021).
date_created: 2021-09-19T22:01:25Z
date_published: 2021-09-01T00:00:00Z
date_updated: 2025-04-14T07:43:46Z
day: '01'
department:
- _id: MaSe
- _id: MiLe
doi: 10.1038/s41586-021-03938-w
ec_funded: 1
external_id:
  arxiv:
  - '2104.00653'
  isi:
  - '000706977400002'
isi: 1
keyword:
- condensed matter - mesoscale and nanoscale physics
- condensed matter - strongly correlated electrons
- multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2104.00653
month: '09'
oa: 1
oa_version: Preprint
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: Nature
publication_identifier:
  eissn:
  - 1476-4687
  issn:
  - 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - relation: erratum
    url: https://doi.org/10.1038/s41586-021-04181-z
scopus_import: '1'
status: public
title: Half and quarter metals in rhombohedral trilayer graphene
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
year: '2021'
...
---
_id: '10029'
abstract:
- lang: eng
  text: Superconductor-semiconductor hybrids are platforms for realizing effective
    p-wave superconductivity. Spin-orbit coupling, combined with the proximity effect,
    causes the two-dimensional semiconductor to inherit p±ip intraband pairing, and
    application of magnetic field can then result in transitions to the normal state,
    partial Bogoliubov Fermi surfaces, or topological phases with Majorana modes.
    Experimentally probing the hybrid superconductor-semiconductor interface is challenging
    due to the shunting effect of the conventional superconductor. Consequently, the
    nature of induced pairing remains an open question. Here, we use the circuit quantum
    electrodynamics architecture to probe induced superconductivity in a two dimensional
    Al-InAs hybrid system. We observe a strong suppression of superfluid density and
    enhanced dissipation driven by magnetic field, which cannot be accounted for by
    the depairing theory of an s-wave superconductor. These observations are explained
    by a picture of independent intraband p±ip superconductors giving way to partial
    Bogoliubov Fermi surfaces, and allow for the first characterization of key properties
    of the hybrid superconducting system.
acknowledged_ssus:
- _id: M-Shop
- _id: NanoFab
acknowledgement: This research was supported by the Scientific Service Units of IST
  Austria through resources provided by the MIBA Machine Shop and the nanofabrication
  facility. JS and AG were supported by funding from the European Union’s Horizon
  2020 research and innovation program under the Marie Sklodowska-Curie Grant Agreement
  No.754411.
article_number: '2107.03695'
article_processing_charge: No
arxiv: 1
author:
- first_name: Duc T
  full_name: Phan, Duc T
  id: 29C8C0B4-F248-11E8-B48F-1D18A9856A87
  last_name: Phan
- first_name: Jorden L
  full_name: Senior, Jorden L
  id: 5479D234-2D30-11EA-89CC-40953DDC885E
  last_name: Senior
  orcid: 0000-0002-0672-9295
- first_name: Areg
  full_name: Ghazaryan, Areg
  id: 4AF46FD6-F248-11E8-B48F-1D18A9856A87
  last_name: Ghazaryan
  orcid: 0000-0001-9666-3543
- first_name: M.
  full_name: Hatefipour, M.
  last_name: Hatefipour
- first_name: W. M.
  full_name: Strickland, W. M.
  last_name: Strickland
- first_name: J.
  full_name: Shabani, J.
  last_name: Shabani
- first_name: Maksym
  full_name: Serbyn, Maksym
  id: 47809E7E-F248-11E8-B48F-1D18A9856A87
  last_name: Serbyn
  orcid: 0000-0002-2399-5827
- first_name: Andrew P
  full_name: Higginbotham, Andrew P
  id: 4AD6785A-F248-11E8-B48F-1D18A9856A87
  last_name: Higginbotham
  orcid: 0000-0003-2607-2363
citation:
  ama: Phan DT, Senior JL, Ghazaryan A, et al. Breakdown of induced p±ip pairing in
    a superconductor-semiconductor hybrid. <i>arXiv</i>. doi:<a href="https://doi.org/10.48550/arXiv.2107.03695">10.48550/arXiv.2107.03695</a>
  apa: Phan, D. T., Senior, J. L., Ghazaryan, A., Hatefipour, M., Strickland, W. M.,
    Shabani, J., … Higginbotham, A. P. (n.d.). Breakdown of induced p±ip pairing in
    a superconductor-semiconductor hybrid. <i>arXiv</i>. <a href="https://doi.org/10.48550/arXiv.2107.03695">https://doi.org/10.48550/arXiv.2107.03695</a>
  chicago: Phan, Duc T, Jorden L Senior, Areg Ghazaryan, M. Hatefipour, W. M. Strickland,
    J. Shabani, Maksym Serbyn, and Andrew P Higginbotham. “Breakdown of Induced P±ip
    Pairing in a Superconductor-Semiconductor Hybrid.” <i>ArXiv</i>, n.d. <a href="https://doi.org/10.48550/arXiv.2107.03695">https://doi.org/10.48550/arXiv.2107.03695</a>.
  ieee: D. T. Phan <i>et al.</i>, “Breakdown of induced p±ip pairing in a superconductor-semiconductor
    hybrid,” <i>arXiv</i>. .
  ista: Phan DT, Senior JL, Ghazaryan A, Hatefipour M, Strickland WM, Shabani J, Serbyn
    M, Higginbotham AP. Breakdown of induced p±ip pairing in a superconductor-semiconductor
    hybrid. arXiv, 2107.03695.
  mla: Phan, Duc T., et al. “Breakdown of Induced P±ip Pairing in a Superconductor-Semiconductor
    Hybrid.” <i>ArXiv</i>, 2107.03695, doi:<a href="https://doi.org/10.48550/arXiv.2107.03695">10.48550/arXiv.2107.03695</a>.
  short: D.T. Phan, J.L. Senior, A. Ghazaryan, M. Hatefipour, W.M. Strickland, J.
    Shabani, M. Serbyn, A.P. Higginbotham, ArXiv (n.d.).
date_created: 2021-09-21T08:41:02Z
date_published: 2021-07-08T00:00:00Z
date_updated: 2025-04-15T06:54:43Z
day: '08'
department:
- _id: MaSe
- _id: AnHi
- _id: MiLe
doi: 10.48550/arXiv.2107.03695
ec_funded: 1
external_id:
  arxiv:
  - '2107.03695'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2107.03695
month: '07'
oa: 1
oa_version: Preprint
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: arXiv
publication_status: draft
related_material:
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    relation: research_data
    status: public
  - id: '10851'
    relation: later_version
    status: public
status: public
title: Breakdown of induced p±ip pairing in a superconductor-semiconductor hybrid
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
OA_place: publisher
_id: '10030'
abstract:
- lang: eng
  text: "This PhD thesis is primarily focused on the study of discrete transport problems,
    introduced for the first time in the seminal works of Maas [Maa11] and Mielke
    [Mie11] on finite state Markov chains and reaction-diffusion equations, respectively.
    More in detail, my research focuses on the study of transport costs on graphs,
    in particular the convergence and the stability of such problems in the discrete-to-continuum
    limit. This thesis also includes some results concerning\r\nnon-commutative optimal
    transport. The first chapter of this thesis consists of a general introduction
    to the optimal transport problems, both in the discrete, the continuous, and the
    non-commutative setting. Chapters 2 and 3 present the content of two works, obtained
    in collaboration with Peter Gladbach, Eva Kopfer, and Jan Maas, where we have
    been able to show the convergence of discrete transport costs on periodic graphs
    to suitable continuous ones, which can be described by means of a homogenisation
    result. We first focus on the particular case of quadratic costs on the real line
    and then extending the result to more general costs in arbitrary dimension. Our
    results are the first complete characterisation of limits of transport costs on
    periodic graphs in arbitrary dimension which do not rely on any additional symmetry.
    In Chapter 4 we turn our attention to one of the intriguing connection between
    evolution equations and optimal transport, represented by the theory of gradient
    flows. We show that discrete gradient flow structures associated to a finite volume
    approximation of a certain class of diffusive equations (Fokker–Planck) is stable
    in the limit of vanishing meshes, reproving the convergence of the scheme via
    the method of evolutionary Γ-convergence and exploiting a more variational point
    of view on the problem. This is based on a collaboration with Dominik Forkert
    and Jan Maas. Chapter 5 represents a change of perspective, moving away from the
    discrete world and reaching the non-commutative one. As in the discrete case,
    we discuss how classical tools coming from the commutative optimal transport can
    be translated into the setting of density matrices. In particular, in this final
    chapter we present a non-commutative version of the Schrödinger problem (or entropic
    regularised optimal transport problem) and discuss existence and characterisation
    of minimisers, a duality result, and present a non-commutative version of the
    well-known Sinkhorn algorithm to compute the above mentioned optimisers. This
    is based on a joint work with Dario Feliciangeli and Augusto Gerolin. Finally,
    Appendix A and B contain some additional material and discussions, with particular
    attention to Harnack inequalities and the regularity of flows on discrete spaces."
acknowledged_ssus:
- _id: M-Shop
- _id: NanoFab
acknowledgement: The author gratefully acknowledges support by the Austrian Science
  Fund (FWF), grants No W1245.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Lorenzo
  full_name: Portinale, Lorenzo
  id: 30AD2CBC-F248-11E8-B48F-1D18A9856A87
  last_name: Portinale
citation:
  ama: Portinale L. Discrete-to-continuum limits of transport problems and gradient
    flows in the space of measures. 2021. doi:<a href="https://doi.org/10.15479/at:ista:10030">10.15479/at:ista:10030</a>
  apa: Portinale, L. (2021). <i>Discrete-to-continuum limits of transport problems
    and gradient flows in the space of measures</i>. Institute of Science and Technology
    Austria. <a href="https://doi.org/10.15479/at:ista:10030">https://doi.org/10.15479/at:ista:10030</a>
  chicago: Portinale, Lorenzo. “Discrete-to-Continuum Limits of Transport Problems
    and Gradient Flows in the Space of Measures.” Institute of Science and Technology
    Austria, 2021. <a href="https://doi.org/10.15479/at:ista:10030">https://doi.org/10.15479/at:ista:10030</a>.
  ieee: L. Portinale, “Discrete-to-continuum limits of transport problems and gradient
    flows in the space of measures,” Institute of Science and Technology Austria,
    2021.
  ista: Portinale L. 2021. Discrete-to-continuum limits of transport problems and
    gradient flows in the space of measures. Institute of Science and Technology Austria.
  mla: Portinale, Lorenzo. <i>Discrete-to-Continuum Limits of Transport Problems and
    Gradient Flows in the Space of Measures</i>. Institute of Science and Technology
    Austria, 2021, doi:<a href="https://doi.org/10.15479/at:ista:10030">10.15479/at:ista:10030</a>.
  short: L. Portinale, Discrete-to-Continuum Limits of Transport Problems and Gradient
    Flows in the Space of Measures, Institute of Science and Technology Austria, 2021.
corr_author: '1'
date_created: 2021-09-21T09:14:15Z
date_published: 2021-09-22T00:00:00Z
date_updated: 2026-04-08T07:00:04Z
day: '22'
ddc:
- '515'
degree_awarded: PhD
department:
- _id: GradSch
- _id: JaMa
doi: 10.15479/at:ista:10030
file:
- access_level: closed
  checksum: 8cd60dcb8762e8f21867e21e8001e183
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  file_size: 3876668
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  date_created: 2021-09-27T11:14:31Z
  date_updated: 2021-09-27T11:14:31Z
  file_id: '10047'
  file_name: thesis_portinale_Final (1).pdf
  file_size: 2532673
  relation: main_file
file_date_updated: 2022-03-10T12:14:42Z
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
project:
- _id: 260788DE-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: W1245
  name: Dissipation and dispersion in nonlinear partial differential equations
- _id: fc31cba2-9c52-11eb-aca3-ff467d239cd2
  grant_number: F6504
  name: Taming Complexity in Partial Differential Systems
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '9792'
    relation: part_of_dissertation
    status: public
  - id: '10022'
    relation: part_of_dissertation
    status: public
  - id: '7573'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Jan
  full_name: Maas, Jan
  id: 4C5696CE-F248-11E8-B48F-1D18A9856A87
  last_name: Maas
  orcid: 0000-0002-0845-1338
title: Discrete-to-continuum limits of transport problems and gradient flows in the
  space of measures
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2021'
...
---
_id: '10033'
abstract:
- lang: eng
  text: The ⊗*-monoidal structure on the category of sheaves on the Ran space is not
    pro-nilpotent in the sense of [3]. However, under some connectivity assumptions,
    we prove that Koszul duality induces an equivalence of categories and that this
    equivalence behaves nicely with respect to Verdier duality on the Ran space and
    integrating along the Ran space, i.e. taking factorization homology. Based on
    ideas sketched in [4], we show that these results also offer a simpler alternative
    to one of the two main steps in the proof of the Atiyah-Bott formula given in
    [7] and [5].
acknowledgement: 'The author would like to express his gratitude to D. Gaitsgory,
  without whose tireless guidance and encouragement in pursuing this problem, this
  work would not have been possible. The author is grateful to his advisor B.C. Ngô
  for many years of patient guidance and support. This paper is revised while the
  author is a postdoc in Hausel group at IST Austria. We thank him and the group for
  providing a wonderful research environment. The author also gratefully acknowledges
  the support of the Lise Meitner fellowship “Algebro-Geometric Applications of Factorization
  Homology,” Austrian Science Fund (FWF): M 2751.'
article_number: '107992'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Quoc P
  full_name: Ho, Quoc P
  id: 3DD82E3C-F248-11E8-B48F-1D18A9856A87
  last_name: Ho
  orcid: 0000-0001-6889-1418
citation:
  ama: Ho QP. The Atiyah-Bott formula and connectivity in chiral Koszul duality. <i>Advances
    in Mathematics</i>. 2021;392. doi:<a href="https://doi.org/10.1016/j.aim.2021.107992">10.1016/j.aim.2021.107992</a>
  apa: Ho, Q. P. (2021). The Atiyah-Bott formula and connectivity in chiral Koszul
    duality. <i>Advances in Mathematics</i>. Elsevier. <a href="https://doi.org/10.1016/j.aim.2021.107992">https://doi.org/10.1016/j.aim.2021.107992</a>
  chicago: Ho, Quoc P. “The Atiyah-Bott Formula and Connectivity in Chiral Koszul
    Duality.” <i>Advances in Mathematics</i>. Elsevier, 2021. <a href="https://doi.org/10.1016/j.aim.2021.107992">https://doi.org/10.1016/j.aim.2021.107992</a>.
  ieee: Q. P. Ho, “The Atiyah-Bott formula and connectivity in chiral Koszul duality,”
    <i>Advances in Mathematics</i>, vol. 392. Elsevier, 2021.
  ista: Ho QP. 2021. The Atiyah-Bott formula and connectivity in chiral Koszul duality.
    Advances in Mathematics. 392, 107992.
  mla: Ho, Quoc P. “The Atiyah-Bott Formula and Connectivity in Chiral Koszul Duality.”
    <i>Advances in Mathematics</i>, vol. 392, 107992, Elsevier, 2021, doi:<a href="https://doi.org/10.1016/j.aim.2021.107992">10.1016/j.aim.2021.107992</a>.
  short: Q.P. Ho, Advances in Mathematics 392 (2021).
corr_author: '1'
date_created: 2021-09-21T15:58:59Z
date_published: 2021-09-21T00:00:00Z
date_updated: 2025-04-14T09:09:35Z
day: '21'
ddc:
- '514'
department:
- _id: TaHa
doi: 10.1016/j.aim.2021.107992
external_id:
  arxiv:
  - '1610.00212'
  isi:
  - '000707040300031'
file:
- access_level: open_access
  checksum: f3c0086d41af11db31c00014efb38072
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  creator: qho
  date_created: 2021-09-21T15:58:52Z
  date_updated: 2021-09-21T15:58:52Z
  file_id: '10034'
  file_name: 1-s2.0-S000187082100431X-main.pdf
  file_size: 840635
  relation: main_file
file_date_updated: 2021-09-21T15:58:52Z
has_accepted_license: '1'
intvolume: '       392'
isi: 1
keyword:
- Chiral algebras
- Chiral homology
- Factorization algebras
- Koszul duality
- Ran space
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
project:
- _id: 26B96266-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: M02751
  name: Algebro-Geometric Applications of Factorization Homology
publication: Advances in Mathematics
publication_identifier:
  eissn:
  - 1090-2082
  issn:
  - 0001-8708
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: The Atiyah-Bott formula and connectivity in chiral Koszul duality
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 392
year: '2021'
...
---
_id: '10051'
abstract:
- lang: eng
  text: 'Rab-interacting molecule (RIM)-binding protein 2 (BP2) is a multidomain protein
    of the presynaptic active zone (AZ). By binding to RIM, bassoon (Bsn), and voltage-gated
    Ca2+ channels (CaV), it is considered to be a central organizer of the topography
    of CaV and release sites of synaptic vesicles (SVs) at the AZ. Here, we used RIM-BP2
    knock-out (KO) mice and their wild-type (WT) littermates of either sex to investigate
    the role of RIM-BP2 at the endbulb of Held synapse of auditory nerve fibers (ANFs)
    with bushy cells (BCs) of the cochlear nucleus, a fast relay of the auditory pathway
    with high release probability. Disruption of RIM-BP2 lowered release probability
    altering short-term plasticity and reduced evoked EPSCs. Analysis of SV pool dynamics
    during high-frequency train stimulation indicated a reduction of SVs with high
    release probability but an overall normal size of the readily releasable SV pool
    (RRP). The Ca2+-dependent fast component of SV replenishment after RRP depletion
    was slowed. Ultrastructural analysis by superresolution light and electron microscopy
    revealed an impaired topography of presynaptic CaV and a reduction of docked and
    membrane-proximal SVs at the AZ. We conclude that RIM-BP2 organizes the topography
    of CaV, and promotes SV tethering and docking. This way RIM-BP2 is critical for
    establishing a high initial release probability as required to reliably signal
    sound onset information that we found to be degraded in BCs of RIM-BP2-deficient
    mice in vivo. SIGNIFICANCE STATEMENT: Rab-interacting molecule (RIM)-binding proteins
    (BPs) are key organizers of the active zone (AZ). Using a multidisciplinary approach
    to the calyceal endbulb of Held synapse that transmits auditory information at
    rates of up to hundreds of Hertz with submillisecond precision we demonstrate
    a requirement for RIM-BP2 for normal auditory signaling. Endbulb synapses lacking
    RIM-BP2 show a reduced release probability despite normal whole-terminal Ca2+
    influx and abundance of the key priming protein Munc13-1, a reduced rate of SV
    replenishment, as well as an altered topography of voltage-gated (CaV)2.1 Ca2+
    channels, and fewer docked and membrane proximal synaptic vesicles (SVs). This
    hampers transmission of sound onset information likely affecting downstream neural
    computations such as of sound localization.'
acknowledgement: This work was supported by the Deutsche Forschungsgemeinschaft (DFG,
  German Research Foundation) through the Collaborative Sensory Research Center 1286
  [to C.W. (A4) and T.M. (B5)] and under Germany’s Excellence Strategy Grant EXC 2067/1-390729940.
  We thank S. Gerke, A.J. Goldak, and C. Senger-Freitag for expert technical assistance;
  G. Hoch for developing image analysis routines; and S. Chepurwar and N. Strenzke
  for technical support and discussion regarding in vivo experiments. We also thank
  Dr. Christian Rosenmund, Dr. Katharina Grauel, and Dr. Stephan Sigrist for providing
  RIM-BP2 KO mice and Dr. Masahiko Watanabe for providing the anti-neurexin-antibody,
  and Dr. Toshihisa Ohtsuka for the anti-ELKS-antibody. J. Neef for help with the
  STED imaging and image analysis; E. Neher and S. Rizzoli for discussion and comments
  on the manuscript; K. Eguchi for help with the statistical analysis; and C. H. Huang
  and J. Neef for constant support and scientific discussion.
article_processing_charge: No
article_type: original
author:
- first_name: Tanvi
  full_name: Butola, Tanvi
  last_name: Butola
- first_name: Theocharis
  full_name: Alvanos, Theocharis
  last_name: Alvanos
- first_name: Anika
  full_name: Hintze, Anika
  last_name: Hintze
- first_name: Peter
  full_name: Koppensteiner, Peter
  id: 3B8B25A8-F248-11E8-B48F-1D18A9856A87
  last_name: Koppensteiner
  orcid: 0000-0002-3509-1948
- first_name: David
  full_name: Kleindienst, David
  id: 42E121A4-F248-11E8-B48F-1D18A9856A87
  last_name: Kleindienst
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Carolin
  full_name: Wichmann, Carolin
  last_name: Wichmann
- first_name: Tobias
  full_name: Moser, Tobias
  last_name: Moser
citation:
  ama: Butola T, Alvanos T, Hintze A, et al. RIM-binding protein 2 organizes Ca<sup>21</sup>
    channel topography and regulates release probability and vesicle replenishment
    at a fast central synapse. <i>Journal of Neuroscience</i>. 2021;41(37):7742-7767.
    doi:<a href="https://doi.org/10.1523/JNEUROSCI.0586-21.2021">10.1523/JNEUROSCI.0586-21.2021</a>
  apa: Butola, T., Alvanos, T., Hintze, A., Koppensteiner, P., Kleindienst, D., Shigemoto,
    R., … Moser, T. (2021). RIM-binding protein 2 organizes Ca<sup>21</sup> channel
    topography and regulates release probability and vesicle replenishment at a fast
    central synapse. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a
    href="https://doi.org/10.1523/JNEUROSCI.0586-21.2021">https://doi.org/10.1523/JNEUROSCI.0586-21.2021</a>
  chicago: Butola, Tanvi, Theocharis Alvanos, Anika Hintze, Peter Koppensteiner, David
    Kleindienst, Ryuichi Shigemoto, Carolin Wichmann, and Tobias Moser. “RIM-Binding
    Protein 2 Organizes Ca<sup>21</sup> Channel Topography and Regulates Release Probability
    and Vesicle Replenishment at a Fast Central Synapse.” <i>Journal of Neuroscience</i>.
    Society for Neuroscience, 2021. <a href="https://doi.org/10.1523/JNEUROSCI.0586-21.2021">https://doi.org/10.1523/JNEUROSCI.0586-21.2021</a>.
  ieee: T. Butola <i>et al.</i>, “RIM-binding protein 2 organizes Ca<sup>21</sup>
    channel topography and regulates release probability and vesicle replenishment
    at a fast central synapse,” <i>Journal of Neuroscience</i>, vol. 41, no. 37. Society
    for Neuroscience, pp. 7742–7767, 2021.
  ista: Butola T, Alvanos T, Hintze A, Koppensteiner P, Kleindienst D, Shigemoto R,
    Wichmann C, Moser T. 2021. RIM-binding protein 2 organizes Ca<sup>21</sup> channel
    topography and regulates release probability and vesicle replenishment at a fast
    central synapse. Journal of Neuroscience. 41(37), 7742–7767.
  mla: Butola, Tanvi, et al. “RIM-Binding Protein 2 Organizes Ca<sup>21</sup> Channel
    Topography and Regulates Release Probability and Vesicle Replenishment at a Fast
    Central Synapse.” <i>Journal of Neuroscience</i>, vol. 41, no. 37, Society for
    Neuroscience, 2021, pp. 7742–67, doi:<a href="https://doi.org/10.1523/JNEUROSCI.0586-21.2021">10.1523/JNEUROSCI.0586-21.2021</a>.
  short: T. Butola, T. Alvanos, A. Hintze, P. Koppensteiner, D. Kleindienst, R. Shigemoto,
    C. Wichmann, T. Moser, Journal of Neuroscience 41 (2021) 7742–7767.
date_created: 2021-09-27T14:33:13Z
date_published: 2021-09-15T00:00:00Z
date_updated: 2023-08-14T06:56:30Z
day: '15'
ddc:
- '570'
department:
- _id: RySh
doi: 10.1523/JNEUROSCI.0586-21.2021
external_id:
  isi:
  - '000752287700005'
  pmid:
  - '34353898'
file:
- access_level: open_access
  checksum: 769ab627c7355a50ccfd445e43a5f351
  content_type: application/pdf
  creator: dernst
  date_created: 2022-05-31T09:10:15Z
  date_updated: 2022-05-31T09:10:15Z
  file_id: '11423'
  file_name: 2021_JourNeuroscience_Butola.pdf
  file_size: 11571961
  relation: main_file
  success: 1
file_date_updated: 2022-05-31T09:10:15Z
has_accepted_license: '1'
intvolume: '        41'
isi: 1
issue: '37'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 7742-7767
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
  eissn:
  - 1529-2401
  issn:
  - 0270-6474
publication_status: published
publisher: Society for Neuroscience
quality_controlled: '1'
scopus_import: '1'
status: public
title: RIM-binding protein 2 organizes Ca<sup>21</sup> channel topography and regulates
  release probability and vesicle replenishment at a fast central synapse
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 41
year: '2021'
...
