---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22734'
abstract:
- lang: eng
  text: Silver selenide (Ag2Se) is a promising near-room-temperature thermoelectric
    material, but its narrow stoichiometric window and β–α phase transition complicate
    reproducible microstructure control. Here, we present a mismatch-assisted microstructure
    engineering strategy in which Ag2Se particles are treated with polyanionic ZnSe
    complexes and consolidated through the β–α transition to introduce ZnSe nanoprecipitates,
    Ag2Se/ZnSe interfaces, and local strain fields. The crystallographic mismatch
    between ZnSe and Ag2Se, together with the Zn2+/Ag+ size difference, amplifies
    phase-transition-induced deformation and promotes high-density dislocations with
    periodic strain modulations. This defect architecture suppresses grain coarsening,
    removes excess Ag, limits Ag-interstitial formation, and reduces lattice thermal
    conductivity through lattice softening and multiscale phonon scattering. Ag2Se–4%ZnSe
    nanocomposites achieve a peak zTmax of 1.13 at 369 K and a zTavg of 1.08 from
    300 to 380 K, demonstrating mismatch-driven defect engineering through the β–α
    phase transition as a route for optimizing Ag2Se-based thermoelectrics.
acknowledged_ssus:
- _id: EM-Fac
- _id: LifeSc
- _id: NanoFab
- _id: MassSpec
acknowledgement: 'Open access funding provided by Institute of Science and Technology
  Austria. M.I. acknowledges financial support from ISTA and the Werner Siemens Foundation.
  The Scientific Service Units (SSU) of ISTA supported this work through resources
  provided by the Electron Microscopy Facility (EMF), the Lab Support Facility (LSF),
  the Nanofabrication Facility (NNF), and the Mass Spectrometry Facility. Y.L. acknowledges
  funding from the National Natural Science Foundation of China (NSFC) (grant no.
  22209034) and the Fundamental Research Funds for the Central Universities (JZ2024HGTB0239).
  M.H. acknowledges funding from Australian Research Council (FT230100316), and the
  high-performance computing resources provided by National Computational Infrastructure
  (it39) and Pawsey Supercomputing Centre (pawsey1075). ICN2 acknowledges funding
  from Generalitat de Catalunya 2021SGR00457. The authors thank support from the project
  AMaDE (PID2023-149158OB-C43), funded by MCIN/AEI/10.13039/501100011033/ and by the
  “ERDF Away of making Europe”, by the “European Union”. ICN2 is supported by the
  Severo Ochoa program from Spanish MCIN/AEI (grant no.: CEX2021-001214-S) and is
  funded by the CERCA Programme/Generalitat de Catalunya. Authors acknowledge the
  use of instrumentation as well as the technical advice provided by the Joint Electron
  Microscopy Center at ALBA (JEMCA). ICN2 acknowledges funding from Grant IU16-014206
  (METCAM-FIB) funded by the European Union through the European Regional Development
  Fund (ERDF), with the support of the Ministry of Research and Universities, Generalitat
  de Catalunya. ICN2 is founding member of e-DREAM. (91)'
article_processing_charge: Yes (via OA deal)
article_type: letter_note
author:
- first_name: Yu
  full_name: Liu, Yu
  id: 2A70014E-F248-11E8-B48F-1D18A9856A87
  last_name: Liu
  orcid: 0000-0001-7313-6740
- first_name: Tobias
  full_name: Kleinhanns, Tobias
  id: 8BD9DE16-AB3C-11E9-9C8C-2A03E6697425
  last_name: Kleinhanns
  orcid: 0000-0003-1537-7436
- first_name: Maria Chiara
  full_name: Spadaro, Maria Chiara
  last_name: Spadaro
- first_name: Aziz
  full_name: Genç, Aziz
  last_name: Genç
- first_name: Sharona
  full_name: Horta, Sharona
  id: 03a7e858-01b1-11ec-8b71-99ae6c4a05bc
  last_name: Horta
- first_name: Navita
  full_name: Navita, Navita
  id: 6ebe278d-ba0b-11ee-8184-f34cdc671de4
  last_name: Navita
  orcid: 0000-0001-7408-8197
- first_name: Tommaso
  full_name: Costanzo, Tommaso
  id: D93824F4-D9BA-11E9-BB12-F207E6697425
  last_name: Costanzo
  orcid: 0000-0001-9732-3815
- first_name: Ewelina
  full_name: Dutkiewicz, Ewelina
  id: 0601cc46-c082-11ec-9b07-bb29641d1de9
  last_name: Dutkiewicz
- first_name: Jordi
  full_name: Arbiol, Jordi
  last_name: Arbiol
- first_name: Min
  full_name: Hong, Min
  last_name: Hong
- first_name: Maria
  full_name: Ibáñez, Maria
  id: 43C61214-F248-11E8-B48F-1D18A9856A87
  last_name: Ibáñez
  orcid: 0000-0001-5013-2843
citation:
  ama: Liu Y, Kleinhanns T, Spadaro MC, et al. Exploiting mismatch strain and the
    β–α phase transition for microstructural engineering in thermoelectric Ag2Se.
    <i>ACS Energy Letters</i>. 2026;11(8):5752-5762. doi:<a href="https://doi.org/10.1021/acsenergylett.6c01499">10.1021/acsenergylett.6c01499</a>
  apa: Liu, Y., Kleinhanns, T., Spadaro, M. C., Genç, A., Horta, S., Jakhar, N., …
    Ibáñez, M. (2026). Exploiting mismatch strain and the β–α phase transition for
    microstructural engineering in thermoelectric Ag2Se. <i>ACS Energy Letters</i>.
    American Chemical Society. <a href="https://doi.org/10.1021/acsenergylett.6c01499">https://doi.org/10.1021/acsenergylett.6c01499</a>
  chicago: Liu, Yu, Tobias Kleinhanns, Maria Chiara Spadaro, Aziz Genç, Sharona Horta,
    Navita Jakhar, Tommaso Costanzo, et al. “Exploiting Mismatch Strain and the β–α
    Phase Transition for Microstructural Engineering in Thermoelectric Ag2Se.” <i>ACS
    Energy Letters</i>. American Chemical Society, 2026. <a href="https://doi.org/10.1021/acsenergylett.6c01499">https://doi.org/10.1021/acsenergylett.6c01499</a>.
  ieee: Y. Liu <i>et al.</i>, “Exploiting mismatch strain and the β–α phase transition
    for microstructural engineering in thermoelectric Ag2Se,” <i>ACS Energy Letters</i>,
    vol. 11, no. 8. American Chemical Society, pp. 5752–5762, 2026.
  ista: Liu Y, Kleinhanns T, Spadaro MC, Genç A, Horta S, Jakhar N, Costanzo T, Dutkiewicz
    E, Arbiol J, Hong M, Ibáñez M. 2026. Exploiting mismatch strain and the β–α phase
    transition for microstructural engineering in thermoelectric Ag2Se. ACS Energy
    Letters. 11(8), 5752–5762.
  mla: Liu, Yu, et al. “Exploiting Mismatch Strain and the β–α Phase Transition for
    Microstructural Engineering in Thermoelectric Ag2Se.” <i>ACS Energy Letters</i>,
    vol. 11, no. 8, American Chemical Society, 2026, pp. 5752–62, doi:<a href="https://doi.org/10.1021/acsenergylett.6c01499">10.1021/acsenergylett.6c01499</a>.
  short: Y. Liu, T. Kleinhanns, M.C. Spadaro, A. Genç, S. Horta, N. Jakhar, T. Costanzo,
    E. Dutkiewicz, J. Arbiol, M. Hong, M. Ibáñez, ACS Energy Letters 11 (2026) 5752–5762.
corr_author: '1'
das_tickbox: '0'
date_created: 2026-08-18T11:34:03Z
date_published: 2026-08-14T00:00:00Z
date_updated: 2026-08-19T05:53:33Z
day: '14'
ddc:
- '540'
department:
- _id: MassSpec
- _id: MaIb
- _id: GradSch
- _id: EM-Fac
doi: 10.1021/acsenergylett.6c01499
file:
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  date_updated: 2026-08-19T05:52:41Z
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fulldoi: https://doi.org/10.1021/acsenergylett.6c01499
has_accepted_license: '1'
intvolume: '        11'
issue: '8'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 5752-5762
project:
- _id: 9B8F7476-BA93-11EA-9121-9846C619BF3A
  name: 'HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of
    Semiconductors for Waste Heat Recovery'
publication: ACS Energy Letters
publication_identifier:
  eissn:
  - 2380-8195
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Exploiting mismatch strain and the β–α phase transition for microstructural
  engineering in thermoelectric Ag2Se
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22715'
abstract:
- lang: eng
  text: 'Grazing-incidence small-angle scattering (GISAS) is a relatively young technique
    with important applications in thin-film technology and untapped potential when
    it comes to 2D analysis on an absolute intensity scale. Approaching standardization
    and reference methods early is foundational for reproducibility and comparability
    across laboratories and reduction of systematic error sources. It underpins trust
    in data obtained and accelerates innovation by ensuring that scientists work from
    a common methodological baseline. Accordingly, obtaining reproducible results
    from different GISAS instruments requires an agreement on how measurements are
    performed, instruments calibrated and terms defined. To pave the way for standardization
    and reference methods, we surveyed GISAS practitioners on what comes before an
    experiment: hardware, software, sample alignment and instrument calibration. Twenty-two
    questions were designed to elucidate the state of the art, which can be used for
    the development of reference methods. Our data on 27 instruments provide the basis
    for standardization. With very few exceptions, we found laboratories prepared
    to implement future reference methods, but no consensus emerges naturally for
    sample alignment and instrument calibration. We, that is the GISAS community,
    are thus in a position to embark on the journey of standardization.'
acknowledgement: "The authors thank all respondents for their participation in the\r\nquestionnaire.
  We plan to make further use of the wealth of\r\nthe dataset going forward. We thank
  Xenocs for sharing\r\napproximate data on GISAXS equipment sales and Adrian\r\nRennie
  for helpful discussions. Open access funding enabled\r\nand organized by Projekt
  DEAL."
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Anja F.
  full_name: Hörmann, Anja F.
  last_name: Hörmann
- first_name: Daniel
  full_name: Balazs, Daniel
  id: 302BADF6-85FC-11EA-9E3B-B9493DDC885E
  last_name: Balazs
  orcid: 0000-0001-7597-043X
- first_name: Ingo
  full_name: Breßler, Ingo
  last_name: Breßler
- first_name: Sumea
  full_name: Klokic, Sumea
  last_name: Klokic
- first_name: Melika
  full_name: Moradi, Melika
  last_name: Moradi
- first_name: Eduardo
  full_name: Solano, Eduardo
  last_name: Solano
- first_name: Annika
  full_name: Stellhorn, Annika
  last_name: Stellhorn
- first_name: Brian R.
  full_name: Pauw, Brian R.
  last_name: Pauw
citation:
  ama: 'Hörmann AF, Balazs D, Breßler I, et al. Grazing-incidence scattering surveyed:
    Towards reference methods for alignment and calibration. <i>Journal of Applied
    Crystallography</i>. 2026;59(4):1247-1253. doi:<a href="https://doi.org/10.1107/S1600576726005741">10.1107/S1600576726005741</a>'
  apa: 'Hörmann, A. F., Balazs, D., Breßler, I., Klokic, S., Moradi, M., Solano, E.,
    … Pauw, B. R. (2026). Grazing-incidence scattering surveyed: Towards reference
    methods for alignment and calibration. <i>Journal of Applied Crystallography</i>.
    International Union of Crystallography. <a href="https://doi.org/10.1107/S1600576726005741">https://doi.org/10.1107/S1600576726005741</a>'
  chicago: 'Hörmann, Anja F., Daniel Balazs, Ingo Breßler, Sumea Klokic, Melika Moradi,
    Eduardo Solano, Annika Stellhorn, and Brian R. Pauw. “Grazing-Incidence Scattering
    Surveyed: Towards Reference Methods for Alignment and Calibration.” <i>Journal
    of Applied Crystallography</i>. International Union of Crystallography, 2026.
    <a href="https://doi.org/10.1107/S1600576726005741">https://doi.org/10.1107/S1600576726005741</a>.'
  ieee: 'A. F. Hörmann <i>et al.</i>, “Grazing-incidence scattering surveyed: Towards
    reference methods for alignment and calibration,” <i>Journal of Applied Crystallography</i>,
    vol. 59, no. 4. International Union of Crystallography, pp. 1247–1253, 2026.'
  ista: 'Hörmann AF, Balazs D, Breßler I, Klokic S, Moradi M, Solano E, Stellhorn
    A, Pauw BR. 2026. Grazing-incidence scattering surveyed: Towards reference methods
    for alignment and calibration. Journal of Applied Crystallography. 59(4), 1247–1253.'
  mla: 'Hörmann, Anja F., et al. “Grazing-Incidence Scattering Surveyed: Towards Reference
    Methods for Alignment and Calibration.” <i>Journal of Applied Crystallography</i>,
    vol. 59, no. 4, International Union of Crystallography, 2026, pp. 1247–53, doi:<a
    href="https://doi.org/10.1107/S1600576726005741">10.1107/S1600576726005741</a>.'
  short: A.F. Hörmann, D. Balazs, I. Breßler, S. Klokic, M. Moradi, E. Solano, A.
    Stellhorn, B.R. Pauw, Journal of Applied Crystallography 59 (2026) 1247–1253.
das_tickbox: '1'
dataavailabilitystatement: "The response data are available at https://doi.org/10.5281/\r\nzenodo.18712813.
  The literate programming source of this\r\nwork is available at https://doi.org/10.5281/zenodo.18713631."
date_created: 2026-08-16T22:01:43Z
date_published: 2026-08-01T00:00:00Z
date_updated: 2026-08-20T06:14:07Z
day: '01'
ddc:
- '540'
department:
- _id: LifeSc
doi: 10.1107/S1600576726005741
file:
- access_level: open_access
  checksum: 8dbad0ab078338021e2cfe722211df7b
  content_type: application/pdf
  creator: dernst
  date_created: 2026-08-20T05:51:36Z
  date_updated: 2026-08-20T05:51:36Z
  file_id: '22739'
  file_name: 2026_JourAppliedCrystallography_Hoermann.pdf
  file_size: 6692218
  relation: main_file
  success: 1
file_date_updated: 2026-08-20T05:51:36Z
fulldoi: https://doi.org/10.1107/S1600576726005741
has_accepted_license: '1'
intvolume: '        59'
issue: '4'
keyword:
- grazing incidence
- reference methods
- calibration
- standardization
- community
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 1247-1253
publication: Journal of Applied Crystallography
publication_identifier:
  eissn:
  - 1600-5767
  issn:
  - 0021-8898
publication_status: published
publisher: International Union of Crystallography
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: no
title: 'Grazing-incidence scattering surveyed: Towards reference methods for alignment
  and calibration'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 59
year: '2026'
...
---
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '22716'
abstract:
- lang: eng
  text: We give an algorithm that, with high probability, maintains a (1-ε)-approximate
    s-t maximum flow in undirected, uncapacitated n-vertex graphs undergoing m edge
    insertions in Õ(m+ n F^*/ε) total update time, where F^{*} is the maximum flow
    on the final graph. This is the first algorithm to achieve polylogarithmic amortized
    update time for dense graphs (m = Ω(n²)), and more generally, for graphs where
    F^* = Õ(m/n). At the heart of our incremental algorithm is the residual graph
    sparsification technique of Karger and Levine [SICOMP '15], originally designed
    for computing exact maximum flows in the static setting. Our main contributions
    are (i) showing how to maintain such sparsifiers for approximate maximum flows
    in the incremental setting and (ii) generalizing the cut sparsification framework
    of Fung et al. [SICOMP '19] from undirected graphs to balanced directed graphs.
acknowledgement: "M. Henzinger: This project has received funding from the European
  Research Council (ERC) under the European Union’s\r\nHorizon 2020 research and innovation
  programme (MoDynStruct, No. 101019564)   and the Austrian Science Fund\r\n(FWF)
  grant DOI 10.55776/Z422, grant DOI 10.55776/I5982, and grant DOI 10.55776/P33775
  with additional funding from the\r\nnetidee SCIENCE Stiftung, 2020–2024. Views and
  opinions expressed are those of the author(s) only and do not necessarily\r\nreflect
  those of the European Union or the European Research Council Executive Agency. Neither
  the European Union nor\r\nthe granting authority can be held responsible for them"
article_number: '31'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Gramoz
  full_name: Goranci, Gramoz
  last_name: Goranci
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
- first_name: Harald
  full_name: Räcke, Harald
  last_name: Räcke
- first_name: A. R.
  full_name: Sricharan, A. R.
  last_name: Sricharan
citation:
  ama: Goranci G, Henzinger M, Räcke H, Sricharan AR. Incremental approximate maximum
    flow via residual graph sparsification. <i>ACM Transactions on Algorithms</i>.
    2026;22(3). doi:<a href="https://doi.org/10.1145/3816252">10.1145/3816252</a>
  apa: Goranci, G., Henzinger, M., Räcke, H., &#38; Sricharan, A. R. (2026). Incremental
    approximate maximum flow via residual graph sparsification. <i>ACM Transactions
    on Algorithms</i>. ACM. <a href="https://doi.org/10.1145/3816252">https://doi.org/10.1145/3816252</a>
  chicago: Goranci, Gramoz, Monika Henzinger, Harald Räcke, and A. R. Sricharan. “Incremental
    Approximate Maximum Flow via Residual Graph Sparsification.” <i>ACM Transactions
    on Algorithms</i>. ACM, 2026. <a href="https://doi.org/10.1145/3816252">https://doi.org/10.1145/3816252</a>.
  ieee: G. Goranci, M. Henzinger, H. Räcke, and A. R. Sricharan, “Incremental approximate
    maximum flow via residual graph sparsification,” <i>ACM Transactions on Algorithms</i>,
    vol. 22, no. 3. ACM, 2026.
  ista: Goranci G, Henzinger M, Räcke H, Sricharan AR. 2026. Incremental approximate
    maximum flow via residual graph sparsification. ACM Transactions on Algorithms.
    22(3), 31.
  mla: Goranci, Gramoz, et al. “Incremental Approximate Maximum Flow via Residual
    Graph Sparsification.” <i>ACM Transactions on Algorithms</i>, vol. 22, no. 3,
    31, ACM, 2026, doi:<a href="https://doi.org/10.1145/3816252">10.1145/3816252</a>.
  short: G. Goranci, M. Henzinger, H. Räcke, A.R. Sricharan, ACM Transactions on Algorithms
    22 (2026).
corr_author: '1'
das_tickbox: '0'
date_created: 2026-08-16T22:01:43Z
date_published: 2026-07-06T00:00:00Z
date_updated: 2026-08-20T06:28:01Z
day: '06'
ddc:
- '000'
department:
- _id: MoHe
doi: 10.1145/3816252
ec_funded: 1
external_id:
  arxiv:
  - '2502.09105'
file:
- access_level: open_access
  checksum: 97969d26dab25c3a35be3ae4dd0fd9ee
  content_type: application/pdf
  creator: dernst
  date_created: 2026-08-20T06:19:51Z
  date_updated: 2026-08-20T06:19:51Z
  file_id: '22740'
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  file_size: 2272512
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file_date_updated: 2026-08-20T06:19:51Z
fulldoi: https://doi.org/10.1145/3816252
has_accepted_license: '1'
intvolume: '        22'
issue: '3'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: bd9ca328-d553-11ed-ba76-dc4f890cfe62
  call_identifier: H2020
  grant_number: '101019564'
  name: The design and evaluation of modern fully dynamic data structures
- _id: 34def286-11ca-11ed-8bc3-da5948e1613c
  grant_number: Z00422
  name: Efficient algorithms
- _id: bda196b2-d553-11ed-ba76-8e8ee6c21103
  grant_number: I05982
  name: Static and Dynamic Hierarchical Graph Decompositions
- _id: bd9e3a2e-d553-11ed-ba76-8aa684ce17fe
  grant_number: P33775
  name: Fast Algorithms for a Reactive Network Layer
publication: ACM Transactions on Algorithms
publication_identifier:
  eissn:
  - 1549-6333
  issn:
  - 1549-6325
publication_status: published
publisher: ACM
quality_controlled: '1'
related_material:
  record:
  - id: '21280'
    relation: earlier_version
    status: public
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Incremental approximate maximum flow via residual graph sparsification
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 22
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '22714'
abstract:
- lang: eng
  text: Radial glial progenitors (RGPs) generate all projection neurons (PNs) in the
    cerebral cortex through incompletely understood processes. We combined Mosaic
    Analysis with Double Markers at embryonic stages (E)12.5 and E13.5 with early
    postnatal callosal tracing to dissect RGP lineage progression. We find that multipotent
    RGPs generate all extra-telencephalic (ET) and intra-telencephalic (IT) PNs via
    parallel sublineages that emerge simultaneously at neurogenesis onset. ET-PN production
    progresses exclusively via small, self-consuming lineages; IT-PN lineages feature
    RGPs generating large translaminar outputs. The early emergence of IT-PN–fated
    RGPs, coinciding with a switch to direct neurogenesis, contributes to the stereotyped
    population-level progression of the multipotent lineage. We also identify POU3F
    transcription factors as candidate regulators of IT-PN fate via noncanonical mitotic
    chromatin binding. The results support a model whereby IT- and ET-PNs arise from
    an early bifurcation and parallel specification within the multipotent RGP lineage.
acknowledgement: 'We thank M. caouyette for the plasmid construction for Pou3f1overexpression;
  d. Pinto-Benito for valuable assistance with shRnA validation in n2A cells andqPcR
  experiments; c. Varela-Martínez for help with the code for graphical analysis; allmembers
  from the nieto’s lab for comment on the manuscript, specially to F. Martín for theinsightful
  discussions; J. c. Oliveros and J. A. García from the computational service of the
  cnBfor help with the analysis of RnAseq dataset; c. O. Sorzano for help with statistical
  analysis; andA. Oña and the service of Advance Optical Microscopy of the cnB for
  technical advice.Funding: i.V.-M. holds a fellowship funded by MciciU (PRe-2018-083376)
  and 2023 eMBOscientific exchange grant 10214. the work was funded by grants to M.n.
  (Pid2020-112831GB- i00 and Pid2023-146322nB- i00 by Mcin/Aei/10.13039/501100011033
  and by“eRdF A way of making europe”).'
article_processing_charge: Yes
article_type: original
author:
- first_name: Irene
  full_name: Varela Martínez, Irene
  id: a69b5985-8829-11f0-8fc2-d0af58f64471
  last_name: Varela Martínez
- first_name: Ana
  full_name: Villalba Requena, Ana
  id: 68cb85a0-39f7-11eb-9559-9aaab4f6a247
  last_name: Villalba Requena
  orcid: 0000-0002-5615-5277
- first_name: Jorge
  full_name: García-Marqués, Jorge
  last_name: García-Marqués
- first_name: Alfonso
  full_name: Aguilera, Alfonso
  last_name: Aguilera
- first_name: Diogo S.
  full_name: Castro, Diogo S.
  last_name: Castro
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: Marta
  full_name: Nieto, Marta
  last_name: Nieto
citation:
  ama: Varela Martínez I, Villalba Requena A, García-Marqués J, et al. Early fate
    diversification of radial glial progenitors during corticogenesis. <i>Science
    Advances</i>. 2026;12(32):eadw5487. doi:<a href="https://doi.org/10.1126/sciadv.adw5487">10.1126/sciadv.adw5487</a>
  apa: Varela Martínez, I., Villalba Requena, A., García-Marqués, J., Aguilera, A.,
    Castro, D. S., Hippenmeyer, S., &#38; Nieto, M. (2026). Early fate diversification
    of radial glial progenitors during corticogenesis. <i>Science Advances</i>. AAAS.
    <a href="https://doi.org/10.1126/sciadv.adw5487">https://doi.org/10.1126/sciadv.adw5487</a>
  chicago: Varela Martínez, Irene, Ana Villalba Requena, Jorge García-Marqués, Alfonso
    Aguilera, Diogo S. Castro, Simon Hippenmeyer, and Marta Nieto. “Early Fate Diversification
    of Radial Glial Progenitors during Corticogenesis.” <i>Science Advances</i>. AAAS,
    2026. <a href="https://doi.org/10.1126/sciadv.adw5487">https://doi.org/10.1126/sciadv.adw5487</a>.
  ieee: I. Varela Martínez <i>et al.</i>, “Early fate diversification of radial glial
    progenitors during corticogenesis,” <i>Science Advances</i>, vol. 12, no. 32.
    AAAS, p. eadw5487, 2026.
  ista: Varela Martínez I, Villalba Requena A, García-Marqués J, Aguilera A, Castro
    DS, Hippenmeyer S, Nieto M. 2026. Early fate diversification of radial glial progenitors
    during corticogenesis. Science Advances. 12(32), eadw5487.
  mla: Varela Martínez, Irene, et al. “Early Fate Diversification of Radial Glial
    Progenitors during Corticogenesis.” <i>Science Advances</i>, vol. 12, no. 32,
    AAAS, 2026, p. eadw5487, doi:<a href="https://doi.org/10.1126/sciadv.adw5487">10.1126/sciadv.adw5487</a>.
  short: I. Varela Martínez, A. Villalba Requena, J. García-Marqués, A. Aguilera,
    D.S. Castro, S. Hippenmeyer, M. Nieto, Science Advances 12 (2026) eadw5487.
das_tickbox: '1'
dataavailabilitystatement: 'All data and code needed to evaluate and reproduce the
  results in the paper are present in the paper and/or the Supplementary Materials.
  Source data underlying all figures (including the clonal atlas) are provided in
  the Supplementary Materials. RnA-seq analysis code has been deposited in Zenodo
  (dOi: 10.5281/zenodo.14609057). this study did not generate new materials.'
date_created: 2026-08-16T22:01:43Z
date_published: 2026-08-07T00:00:00Z
date_updated: 2026-08-20T05:45:28Z
day: '07'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1126/sciadv.adw5487
external_id:
  pmid:
  - '42555737'
file:
- access_level: open_access
  checksum: 487c3703387080e8f3c4675d67763f0e
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  creator: dernst
  date_created: 2026-08-20T05:39:32Z
  date_updated: 2026-08-20T05:39:32Z
  file_id: '22738'
  file_name: 2026_ScienceAdv_VarelaMartinez.pdf
  file_size: 3056744
  relation: main_file
  success: 1
file_date_updated: 2026-08-20T05:39:32Z
fulldoi: https://doi.org/10.1126/sciadv.adw5487
has_accepted_license: '1'
intvolume: '        12'
issue: '32'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: eadw5487
pmid: 1
publication: Science Advances
publication_identifier:
  eissn:
  - 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Early fate diversification of radial glial progenitors during corticogenesis
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22733'
abstract:
- lang: eng
  text: Sleep need is associated with both circuit dynamics and widespread synaptic
    plasticity, yet the specific synaptic changes underlying sleep homeostasis remain
    incompletely understood. In Drosophila, sleep loss has been shown to trigger plasticity
    of the presynaptic active zone, marked by increasing levels of the ELKS-family
    scaffold protein Bruchpilot (BRP). By titrating brp gene copy number, we previously
    established a presynapse-specific, dosage-dependent paradigm that modulates sleep
    pressure. Here, to elucidate the molecular landscape of this plasticity, we performed
    synapse-enriched integrated-omics. Proteomic and bioinformatic analyses revealed
    changes in immune and stress response pathways and local translation control.
    Strikingly, phospho-proteomic analysis uncovered a global shift toward hypophosphorylation,
    particularly in presynaptic proteins, indicating a reprogramming of the phosphorylation–dephosphorylation
    balance. This presynaptic hypophosphorylation is likely contributed by reduced
    activity of Protein Kinase A (PKA) and enhanced substrate affinity of Protein
    Phosphatase 1 (PP1) mediated by its regulatory subunit Spinophilin (Spn). Manipulating
    either PKA or PP1 activity was sufficient to suppress BRP-modulated sleep phenotypes.
    We propose that presynaptic hypophosphorylation constitutes a molecular signature
    of local synaptic remodeling that adaptively tunes sleep need via reversible posttranslational
    modification, a mechanism likely conserved across species.
article_number: e2524065123
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Chengji
  full_name: Piao, Chengji
  last_name: Piao
- first_name: Ewelina
  full_name: Dutkiewicz, Ewelina
  id: 0601cc46-c082-11ec-9b07-bb29641d1de9
  last_name: Dutkiewicz
- first_name: Laxmikanth
  full_name: Kollipara, Laxmikanth
  last_name: Kollipara
- first_name: Albert
  full_name: Sickmann, Albert
  last_name: Sickmann
- first_name: Sheng
  full_name: Huang, Sheng
  last_name: Huang
- first_name: Stephan J.
  full_name: Sigrist, Stephan J.
  last_name: Sigrist
citation:
  ama: Piao C, Dutkiewicz E, Kollipara L, Sickmann A, Huang S, Sigrist SJ. Active
    zone plasticity couples sleep need to presynaptic hypophosphorylation. <i>Proceedings
    of the National Academy of Sciences</i>. 2026;123(24). doi:<a href="https://doi.org/10.1073/pnas.2524065123">10.1073/pnas.2524065123</a>
  apa: Piao, C., Dutkiewicz, E., Kollipara, L., Sickmann, A., Huang, S., &#38; Sigrist,
    S. J. (2026). Active zone plasticity couples sleep need to presynaptic hypophosphorylation.
    <i>Proceedings of the National Academy of Sciences</i>. National Academy of Sciences.
    <a href="https://doi.org/10.1073/pnas.2524065123">https://doi.org/10.1073/pnas.2524065123</a>
  chicago: Piao, Chengji, Ewelina Dutkiewicz, Laxmikanth Kollipara, Albert Sickmann,
    Sheng Huang, and Stephan J. Sigrist. “Active Zone Plasticity Couples Sleep Need
    to Presynaptic Hypophosphorylation.” <i>Proceedings of the National Academy of
    Sciences</i>. National Academy of Sciences, 2026. <a href="https://doi.org/10.1073/pnas.2524065123">https://doi.org/10.1073/pnas.2524065123</a>.
  ieee: C. Piao, E. Dutkiewicz, L. Kollipara, A. Sickmann, S. Huang, and S. J. Sigrist,
    “Active zone plasticity couples sleep need to presynaptic hypophosphorylation,”
    <i>Proceedings of the National Academy of Sciences</i>, vol. 123, no. 24. National
    Academy of Sciences, 2026.
  ista: Piao C, Dutkiewicz E, Kollipara L, Sickmann A, Huang S, Sigrist SJ. 2026.
    Active zone plasticity couples sleep need to presynaptic hypophosphorylation.
    Proceedings of the National Academy of Sciences. 123(24), e2524065123.
  mla: Piao, Chengji, et al. “Active Zone Plasticity Couples Sleep Need to Presynaptic
    Hypophosphorylation.” <i>Proceedings of the National Academy of Sciences</i>,
    vol. 123, no. 24, e2524065123, National Academy of Sciences, 2026, doi:<a href="https://doi.org/10.1073/pnas.2524065123">10.1073/pnas.2524065123</a>.
  short: C. Piao, E. Dutkiewicz, L. Kollipara, A. Sickmann, S. Huang, S.J. Sigrist,
    Proceedings of the National Academy of Sciences 123 (2026).
date_created: 2026-08-18T10:46:33Z
date_published: 2026-06-16T00:00:00Z
date_updated: 2026-08-20T05:35:33Z
day: '16'
ddc:
- '570'
doi: 10.1073/pnas.2524065123
extern: '1'
external_id:
  pmid:
  - '42258713'
file:
- access_level: open_access
  checksum: 3727c5ad18c1e9c65672fbb01ac6ea04
  content_type: application/pdf
  creator: dernst
  date_created: 2026-08-20T05:34:25Z
  date_updated: 2026-08-20T05:34:25Z
  file_id: '22737'
  file_name: 2026_PNAS_Piao.pdf
  file_size: 3915000
  relation: main_file
  success: 1
file_date_updated: 2026-08-20T05:34:25Z
fulldoi: https://doi.org/10.1073/pnas.2524065123
has_accepted_license: '1'
intvolume: '       123'
issue: '24'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
publication: Proceedings of the National Academy of Sciences
publication_identifier:
  issn:
  - 0027-8424
  - 1091-6490
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Active zone plasticity couples sleep need to presynaptic hypophosphorylation
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 123
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '22712'
abstract:
- lang: eng
  text: Ginseng (Panax ginseng) derives its renowned therapeutic properties from ginsenoside
    metabolites. However, the long cultivation cycle and susceptibility to diseases
    hinder the advancement of the ginseng industry. Here, we demonstrate that the
    embryonic protoderm of ginseng can efficiently produce ginsenosides. Single-cell
    transcriptome and mass spectrometry imaging analyses reveal that ginsenosides
    accumulate in the protoderm of ginseng embryonic callus (EC) at levels comparable
    to those in forest ginseng. Epigenetic analyses indicate that elevated histone
    acetylation and enhanced chromatin accessibility at regeneration- and ginsenoside
    metabolism-related gene loci are associated with the ginsenoside-producing capacity
    of EC. Increasing histone acetylation levels or overexpressing the regeneration-related
    WUSCHEL-RELATED HOMEOBOX11 (WOX11) gene further enhances ginsenoside production
    in EC. Our findings suggest that the protoderm of EC could serve as an in situ
    biological compartment for high-efficiency ginsenoside producion, offering a complementary
    approach to traditional ginseng cultivation.
acknowledgement: 'The authors are grateful to Professor Linfeng Li from the School
  of Life Science, Fudan University, for his assistance during the ginseng genome
  annotation. This work was supported by Key project at central government level:
  The ability establishment of sustainable use for valuable Chinese medicine resources
  (2060302-2401-08 to L.X. and J.L.), the National Natural Science Foundation of China
  (82373987 to J.L., 31701294 to L.X., 32225007 to L.X., and 32300285 to N.Z.), the
  Fundamental Research Funds for the Central public welfare research institutes (ZZ13-YQ-093,
  ZZXT202508 to J.L.), the CACMS Innovation Fund (CI2025G00-06 to J.L.), the Principle
  Investigator Program (HBMUPI202104 to Y.Z.), the Key R&D Program of Shandong Province,
  China (2024LZGC025 to L.X.), the National Key R&D Program of China (2024YFF1000700/2023YFE0101100
  to L.X.), Strategic Priority Research Program of Chinese Academy of Sciences (XDB0630000
  to L.X.), and China Postdoctoral Science Foundation (2023M733490 to N.Z.).'
article_number: '7994'
article_processing_charge: Yes
article_type: original
author:
- first_name: Juan
  full_name: Liu, Juan
  last_name: Liu
- first_name: Ning
  full_name: Zhai, Ning
  last_name: Zhai
- first_name: Shiyi
  full_name: Zhang, Shiyi
  last_name: Zhang
- first_name: Yosuke
  full_name: Tamada, Yosuke
  last_name: Tamada
- first_name: Tonghui
  full_name: Li, Tonghui
  last_name: Li
- first_name: Linfan
  full_name: Zhang, Linfan
  last_name: Zhang
- first_name: Tong
  full_name: Chen, Tong
  last_name: Chen
- first_name: Chenglin
  full_name: Wang, Chenglin
  last_name: Wang
- first_name: Jian
  full_name: Yang, Jian
  last_name: Yang
- first_name: Jiaqi
  full_name: Gao, Jiaqi
  last_name: Gao
- first_name: Xiang
  full_name: Li, Xiang
  id: 4B7E523C-F248-11E8-B48F-1D18A9856A87
  last_name: Li
- first_name: Junhui
  full_name: Zhou, Junhui
  last_name: Zhou
- first_name: Yonghong
  full_name: Zhang, Yonghong
  last_name: Zhang
- first_name: Yu
  full_name: Liu, Yu
  id: 2A70014E-F248-11E8-B48F-1D18A9856A87
  last_name: Liu
  orcid: 0000-0001-7313-6740
- first_name: Yuan
  full_name: Wang, Yuan
  last_name: Wang
- first_name: Jiří
  full_name: Friml, Jiří
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
- first_name: Chen
  full_name: Li, Chen
  last_name: Li
- first_name: Lin
  full_name: Xu, Lin
  last_name: Xu
- first_name: Luqi
  full_name: Huang, Luqi
  last_name: Huang
citation:
  ama: Liu J, Zhai N, Zhang S, et al. Single-cell analyses identify the ginseng embryonic
    protoderm as a native compartment for high-efficiency ginsenoside production.
    <i>Nature Communications</i>. 2026;17. doi:<a href="https://doi.org/10.1038/s41467-026-74881-5">10.1038/s41467-026-74881-5</a>
  apa: Liu, J., Zhai, N., Zhang, S., Tamada, Y., Li, T., Zhang, L., … Huang, L. (2026).
    Single-cell analyses identify the ginseng embryonic protoderm as a native compartment
    for high-efficiency ginsenoside production. <i>Nature Communications</i>. Springer
    Nature. <a href="https://doi.org/10.1038/s41467-026-74881-5">https://doi.org/10.1038/s41467-026-74881-5</a>
  chicago: Liu, Juan, Ning Zhai, Shiyi Zhang, Yosuke Tamada, Tonghui Li, Linfan Zhang,
    Tong Chen, et al. “Single-Cell Analyses Identify the Ginseng Embryonic Protoderm
    as a Native Compartment for High-Efficiency Ginsenoside Production.” <i>Nature
    Communications</i>. Springer Nature, 2026. <a href="https://doi.org/10.1038/s41467-026-74881-5">https://doi.org/10.1038/s41467-026-74881-5</a>.
  ieee: J. Liu <i>et al.</i>, “Single-cell analyses identify the ginseng embryonic
    protoderm as a native compartment for high-efficiency ginsenoside production,”
    <i>Nature Communications</i>, vol. 17. Springer Nature, 2026.
  ista: Liu J, Zhai N, Zhang S, Tamada Y, Li T, Zhang L, Chen T, Wang C, Yang J, Gao
    J, Li X, Zhou J, Zhang Y, Liu Y, Wang Y, Friml J, Benková E, Li C, Xu L, Huang
    L. 2026. Single-cell analyses identify the ginseng embryonic protoderm as a native
    compartment for high-efficiency ginsenoside production. Nature Communications.
    17, 7994.
  mla: Liu, Juan, et al. “Single-Cell Analyses Identify the Ginseng Embryonic Protoderm
    as a Native Compartment for High-Efficiency Ginsenoside Production.” <i>Nature
    Communications</i>, vol. 17, 7994, Springer Nature, 2026, doi:<a href="https://doi.org/10.1038/s41467-026-74881-5">10.1038/s41467-026-74881-5</a>.
  short: J. Liu, N. Zhai, S. Zhang, Y. Tamada, T. Li, L. Zhang, T. Chen, C. Wang,
    J. Yang, J. Gao, X. Li, J. Zhou, Y. Zhang, Y. Liu, Y. Wang, J. Friml, E. Benková,
    C. Li, L. Xu, L. Huang, Nature Communications 17 (2026).
das_tickbox: '1'
dataavailabilitystatement: The RNA-seq data generated in this study have been deposited
  in the GSA database under accession code CRA008967. The scRNA-seq data generated
  in this study have been deposited in the GSA database under accession code CRA026200.
  The ATAC-seq data generated in this study have been deposited in the GSA database
  under accession code CRA008969. The ChIP-seq data generated in this study have been
  deposited in the GSA database under accession code CRA008968. Single-cell RNA-seq
  data and scripts are publicly available on Zenodo (https://zenodo.org/records/20392012).
  Primers are in Supplemental Table 5. Source data are provided with this paper.
date_created: 2026-08-16T22:01:42Z
date_published: 2026-08-07T00:00:00Z
date_updated: 2026-08-20T06:45:46Z
day: '07'
ddc:
- '580'
department:
- _id: JiFr
- _id: EvBe
doi: 10.1038/s41467-026-74881-5
external_id:
  pmid:
  - '42350386'
file:
- access_level: open_access
  checksum: 0b4ff29f0d0168b11be32a5f22ded9e4
  content_type: application/pdf
  creator: dernst
  date_created: 2026-08-20T06:44:33Z
  date_updated: 2026-08-20T06:44:33Z
  file_id: '22742'
  file_name: 2026_NatureComm_Liu.pdf
  file_size: 2429551
  relation: main_file
  success: 1
file_date_updated: 2026-08-20T06:44:33Z
fulldoi: https://doi.org/10.1038/s41467-026-74881-5
has_accepted_license: '1'
intvolume: '        17'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Single-cell analyses identify the ginseng embryonic protoderm as a native compartment
  for high-efficiency ginsenoside production
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
OA_place: repository
_id: '22687'
abstract:
- lang: eng
  text: "Understanding enzyme function requires characterizing not only static structure
    but also dynamics and ligand interactions. NMR spectroscopy provides this insight
    at atomic resolution, yet for large proteins the difficulty of resonance assignment
    has largely confined such studies to systems below ∼50 kDa, or to observing only
    methyl groups. Here we present an integrated magic-angle spinning (MAS) and solution
    NMR study of the 134 kDa tetrameric malate dehydrogenase from Ignicoccus islandicus
    (IiMDH), an enzyme of particular interest as an evolutionary intermediate between
    allosteric lactate\r\ndehydrogenases and non-allosteric malate dehydrogenases.
    By combining high-dimensional (up to 4D) MAS NMR experiments on sedimented protein
    with solution NMR, we achieved 92% backbone heavy- atom assignment and 91% assignment
    of all Ile-δ1, Leu-δ1/-δ2, Val-γ1/-γ2, Met-ε and Thr-γ methyl groups. Building
    on these assignments, we use various probes of backbone and sidechain dynamics:
    elevated MAS NMR 15N rotating-frame relaxation (R1ρ) points to microsecond motions
    in functionally critical regions, including the catalytic loop and the mobile
    surface loop. Complementary methyl-axis order parameters from solution NMR identified
    additional flexible sites in the hydrophobic core. Chemical shift perturbation
    experiments upon addition of the substrate analogue oxamate, monitored via backbone
    1H-15N TROSY, revealed both active-site contacts and responses in helices α2F
    and α3G, regions implicated in allosteric signal transmission. The integrated
    approach demonstrated here exploits the distinct strengths of MAS and solution
    NMR, and provides a comprehensive view of structure, dynamics, and substrate interactions
    in a large oligomeric enzyme that would not be accessible by either technique
    alone."
acknowledged_ssus:
- _id: NMR
- _id: LifeSc
acknowledgement: This research was supported by the Scientific Service Units (SSU)
  of Institute of Science and Technology Austria (ISTA) through resources provided
  by the Nuclear Magnetic Resonance and the Lab Support Facilities. We thank Petra
  Rovó, Megha Mohan and Margarita Valhondo Falcón for excellent support of the NMR
  facility.
article_processing_charge: No
author:
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
- first_name: Federico
  full_name: Napoli, Federico
  id: d42e08e7-f4fc-11eb-af0a-d71e26138f1b
  last_name: Napoli
  orcid: 0000-0002-9043-136X
citation:
  ama: 'Schanda P, Napoli F. Data and scripts for: “Integrated solid/solution NMR
    assignment allows mapping dynamics and ligand binding in a 134 kDa enzyme.” 2026.
    doi:<a href="https://doi.org/10.15479/AT-ISTA-22687">10.15479/AT-ISTA-22687</a>'
  apa: 'Schanda, P., &#38; Napoli, F. (2026). Data and scripts for: “Integrated solid/solution
    NMR assignment allows mapping dynamics and ligand binding in a 134 kDa enzyme.”
    Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-22687">https://doi.org/10.15479/AT-ISTA-22687</a>'
  chicago: 'Schanda, Paul, and Federico Napoli. “Data and Scripts for: ‘Integrated
    Solid/Solution NMR Assignment Allows Mapping Dynamics and Ligand Binding in a
    134 KDa Enzyme.’” Institute of Science and Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-22687">https://doi.org/10.15479/AT-ISTA-22687</a>.'
  ieee: 'P. Schanda and F. Napoli, “Data and scripts for: ‘Integrated solid/solution
    NMR assignment allows mapping dynamics and ligand binding in a 134 kDa enzyme.’”
    Institute of Science and Technology Austria, 2026.'
  ista: 'Schanda P, Napoli F. 2026. Data and scripts for: ‘Integrated solid/solution
    NMR assignment allows mapping dynamics and ligand binding in a 134 kDa enzyme’,
    Institute of Science and Technology Austria, <a href="https://doi.org/10.15479/AT-ISTA-22687">10.15479/AT-ISTA-22687</a>.'
  mla: 'Schanda, Paul, and Federico Napoli. <i>Data and Scripts for: “Integrated Solid/Solution
    NMR Assignment Allows Mapping Dynamics and Ligand Binding in a 134 KDa Enzyme.”</i>
    Institute of Science and Technology Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-22687">10.15479/AT-ISTA-22687</a>.'
  short: P. Schanda, F. Napoli, (2026).
contributor:
- contributor_type: researcher
  first_name: Federico
  id: d42e08e7-f4fc-11eb-af0a-d71e26138f1b
  last_name: Napoli
  orcid: 0000-0002-9043-136X
- contributor_type: project_leader
  first_name: Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
- contributor_type: project_member
  first_name: Rajkumar
  id: a3089acd-6806-11ee-bacc-f0c7d500ad20
  last_name: Singh
- contributor_type: project_member
  first_name: Anna
  id: 9fb2a840-89e1-11ee-a8b7-cc5c7ba62471
  last_name: Kapitonova
- contributor_type: project_member
  first_name: Virgil
  last_name: Aitenbichler
- contributor_type: project_member
  first_name: Giorgia
  id: 334a5e40-8747-11f0-b671-ba1f5154b4b4
  last_name: Toscano
- contributor_type: data_collector
  first_name: Barbara
  last_name: Perrone
corr_author: '1'
date_created: 2026-08-12T16:12:19Z
date_published: 2026-08-20T00:00:00Z
date_updated: 2026-08-20T07:40:15Z
day: '20'
department:
- _id: PaSc
doi: 10.15479/AT-ISTA-22687
doi_confirm: '1'
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month: '08'
oa: 1
oa_version: None
project:
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  grant_number: I05812
  name: AlloSpace. The emergence and mechanisms of allostery
publisher: Institute of Science and Technology Austria
status: public
title: 'Data and scripts for: "Integrated solid/solution NMR assignment allows mapping
  dynamics and ligand binding in a 134 kDa enzyme"'
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type: research_data
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...
---
OA_place: publisher
_id: '22694'
abstract:
- lang: eng
  text: "We develop and employ techniques from equivariant algebraic K-theory and
    related invariants\r\nin the context of geometric representation theory, in both
    arithmetic and topological situations.\r\nWe showcase the use of such techniques
    on the affine Grassmannian Gr, a space of fundamental\r\ninterest in the geometric
    Langlands program.\r\n\r\nIt is a deep development of mathematics of the last
    century that many concrete, yet combina-\r\ntorially complex algebraic problems
    may be effectively studied through the lens of algebraic\r\ngeometry. The objects
    of interest can be often realized as cohomological invariants of algebraic\r\nvarieties,
    and good understanding of their geometry sheds light into the original questions.\r\nSuch
    techniques have seen immense applications in the Langlands program, where they
    go\r\nunder the label of geometric representation theory.\r\n\r\nOne source of
    powerful invariants in algebraic geometry comes from algebraic K-theory,\r\nHochschild
    homology, and their relatives. These localizing invariants contain large amount\r\nof
    information, but are quite hard to compute. For this reason, their usage in geometric\r\nrepresentation
    theory has been limited.\r\n\r\nThe aim of this thesis is to showcase how to control
    such invariants in the situations of\r\ninterest and use them to obtain new insights.
    We start by reinterpreting equivariant Hochschild\r\nhomology in terms of functions
    on certain fixed-point schemes, which are of independent\r\ninterest. We compare
    it to equivariant K-theory via the trace map. We give new computations\r\nand
    comparisons of such invariants of affine Schubert varieties in Gr, including arithmetic\r\nsituations.
    We show that they behave much better than expected.\r\n\r\nWe finally utilize
    this circle of ideas in a purely topological setting. We describe the varying\r\nfixed
    points of the extended torus action on the affine Grassmannian, and use it to
    compute\r\nits equivariant topological K-theory ring. The answer is nontrivial
    and verifies an outstanding\r\nconjecture in the subject.\r\n\r\nWe compare, partly
    conjecturally, the resulting K-theory ring to the completed center of an\r\nintegral
    even hybrid quantum group and its deformed quantum category O. This gives a\r\ngenuine
    application of our computations in pure representation theory."
acknowledgement: "It was funded by a DOC Fellowship of the Austrian Academy of Sciences
  entitled Arithmetic,\r\ngeometry, topology and representation theory arising from
  the affine Grassmannian. It was\r\nfurther funded by the Austrian Science Fund FWF
  10.55776/P35847, and an Erasmus+ staff\r\nmobility training. \r\n"
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Jakub
  full_name: Löwit, Jakub
  id: e3b80ae2-eb8e-11eb-b029-9aef4a9108a0
  last_name: Löwit
citation:
  ama: Löwit J. Equivariant K-theory of affine Grassmannians in representation theory
    and arithmetic. 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-22694">10.15479/AT-ISTA-22694</a>
  apa: Löwit, J. (2026). <i>Equivariant K-theory of affine Grassmannians in representation
    theory and arithmetic</i>. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-22694">https://doi.org/10.15479/AT-ISTA-22694</a>
  chicago: Löwit, Jakub. “Equivariant K-Theory of Affine Grassmannians in Representation
    Theory and Arithmetic.” Institute of Science and Technology Austria, 2026. <a
    href="https://doi.org/10.15479/AT-ISTA-22694">https://doi.org/10.15479/AT-ISTA-22694</a>.
  ieee: J. Löwit, “Equivariant K-theory of affine Grassmannians in representation
    theory and arithmetic,” Institute of Science and Technology Austria, 2026.
  ista: Löwit J. 2026. Equivariant K-theory of affine Grassmannians in representation
    theory and arithmetic. Institute of Science and Technology Austria.
  mla: Löwit, Jakub. <i>Equivariant K-Theory of Affine Grassmannians in Representation
    Theory and Arithmetic</i>. Institute of Science and Technology Austria, 2026,
    doi:<a href="https://doi.org/10.15479/AT-ISTA-22694">10.15479/AT-ISTA-22694</a>.
  short: J. Löwit, Equivariant K-Theory of Affine Grassmannians in Representation
    Theory and Arithmetic, Institute of Science and Technology Austria, 2026.
corr_author: '1'
date_created: 2026-08-12T14:05:36Z
date_published: 2026-08-05T00:00:00Z
date_updated: 2026-08-26T06:53:55Z
day: '05'
ddc:
- '510'
- '516'
- '512'
- '514'
- '513'
degree_awarded: PhD
department:
- _id: GradSch
- _id: TaHa
doi: 10.15479/AT-ISTA-22694
doi_confirm: '1'
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fulldoi: https://doi.org/10.15479/AT-ISTA-22694
has_accepted_license: '1'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: '185'
project:
- _id: 901e2a43-16d5-11f0-9cad-9cead34748d6
  grant_number: '27004'
  name: Arithmetic, geometry, topology and representation theory arising from the
    affine Grassmannian
- _id: 34b2c9cb-11ca-11ed-8bc3-a50ba74ca4a3
  grant_number: P35847
  name: Geometry of the tip of the global nilpotent cone
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publisher_comment: "For open access purposes, the author has applied a CC BY public
  copyright\r\nlicense to any author-accepted manuscript version arising from this
  submission."
related_material:
  record:
  - id: '21751'
    relation: part_of_dissertation
    status: public
  - id: '22693'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Tamás
  full_name: Hausel, Tamás
  id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
  last_name: Hausel
  orcid: 0000-0002-9582-2634
title: Equivariant K-theory of affine Grassmannians in representation theory and arithmetic
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  short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2026'
...
---
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OA_type: hybrid
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_id: '21751'
abstract:
- lang: eng
  text: 'We define a certain class of simple varieties over a field k by a constructive
    recipe and show how to control their (equivariant) truncating invariants. Consequently,
    we prove that on simple varieties: (i) if k = k and char k = p, the p-adic cyclotomic
    trace is an equivalence; (ii) if k = Q, the Goodwillie–Jones trace is an isomorphism
    in degree zero; (iii) we can control homotopy invariant K-theory KH, which is
    equivariantly formal and determined by its topological counterparts. Simple varieties
    are quite special, but encompass important singular examples appearing in geometric
    representation theory. We, in particular, show that both finite and affine Schubert
    varieties for GLn lie in this class, so all the above results hold for them. '
acknowledgement: "This work was supported by a DOC Fellowship of the Austrian Academy
  of Sciences at the Institute of Science and Technology Austria (ISTA) and by an
  Erasmus+ staff mobility training. It took place during the author’s visit to Laboratoire
  de Mathématiques d’Orsay in the course of his PhD at the Institute of Science and
  Technology Austria. First and foremost, I would like to thank Matthew Morrow for
  discussions, explanations and ideas without which this work would not have been
  carried out. I would further like to thank Brian Conrad for providing an amazing
  reference on projective cones in appropriate generality, to Vova Sosnilo for carefully
  discussing – among other things – the derived nilinvariance for quotients by any
  linearly reductive group, and to Adeel Khan, Timo Richarz, Matthias Wendt and Xinwen
  Zhu for helpful conversations\r\nabout the results. I would moreover like to thank
  the referee for the very useful comments."
article_number: rnag058
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Jakub
  full_name: Löwit, Jakub
  id: e3b80ae2-eb8e-11eb-b029-9aef4a9108a0
  last_name: Löwit
citation:
  ama: Löwit J. Equivariant localizing invariants of simple varieties. <i>International
    Mathematics Research Notices</i>. 2026;2026(7). doi:<a href="https://doi.org/10.1093/imrn/rnag058">10.1093/imrn/rnag058</a>
  apa: Löwit, J. (2026). Equivariant localizing invariants of simple varieties. <i>International
    Mathematics Research Notices</i>. Oxford University Press. <a href="https://doi.org/10.1093/imrn/rnag058">https://doi.org/10.1093/imrn/rnag058</a>
  chicago: Löwit, Jakub. “Equivariant Localizing Invariants of Simple Varieties.”
    <i>International Mathematics Research Notices</i>. Oxford University Press, 2026.
    <a href="https://doi.org/10.1093/imrn/rnag058">https://doi.org/10.1093/imrn/rnag058</a>.
  ieee: J. Löwit, “Equivariant localizing invariants of simple varieties,” <i>International
    Mathematics Research Notices</i>, vol. 2026, no. 7. Oxford University Press, 2026.
  ista: Löwit J. 2026. Equivariant localizing invariants of simple varieties. International
    Mathematics Research Notices. 2026(7), rnag058.
  mla: Löwit, Jakub. “Equivariant Localizing Invariants of Simple Varieties.” <i>International
    Mathematics Research Notices</i>, vol. 2026, no. 7, rnag058, Oxford University
    Press, 2026, doi:<a href="https://doi.org/10.1093/imrn/rnag058">10.1093/imrn/rnag058</a>.
  short: J. Löwit, International Mathematics Research Notices 2026 (2026).
corr_author: '1'
date_created: 2026-04-19T22:07:48Z
date_published: 2026-04-01T00:00:00Z
date_updated: 2026-08-26T06:53:54Z
day: '01'
ddc:
- '510'
department:
- _id: TaHa
doi: 10.1093/imrn/rnag058
external_id:
  arxiv:
  - '2507.09392'
file:
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  date_updated: 2026-05-06T06:35:05Z
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  file_name: 2026_IMRN_Loewit.pdf
  file_size: 1663246
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  success: 1
file_date_updated: 2026-05-06T06:35:05Z
fulldoi: https://doi.org/10.1093/imrn/rnag058
has_accepted_license: '1'
intvolume: '      2026'
issue: '7'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: 901e2a43-16d5-11f0-9cad-9cead34748d6
  grant_number: '27004'
  name: Arithmetic, geometry, topology and representation theory arising from the
    affine Grassmannian
publication: International Mathematics Research Notices
publication_identifier:
  eissn:
  - 1687-0247
  issn:
  - 1073-7928
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
related_material:
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  - id: '22694'
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    status: public
scopus_import: '1'
status: public
title: Equivariant localizing invariants of simple varieties
tmp:
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  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2026
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22693'
abstract:
- lang: eng
  text: We study torus-equivariant algebraic K-theory of affine Schubert varieties
    in the perfect affine Grassmannians over Fp. We further compare it to the torus-equivariant
    Hochschild homology of perfect complexes, which has a geometric description in
    terms of global functions on certain fixed-point schemes. We prove that Fp-linearly,
    this comparison is an isomorphism. Our approach is quite constructive, resulting
    in new computations of these K-theory rings. We establish various structural results
    for equivariant perfect algebraic K-theory on the way; we believe these are of
    independent interest.
acknowledgement: "I would like to thank the following people for fruitful discussions,\r\nhelpful
  sanity checks or comments on previous drafts: Roman Bezrukavnikov, Jens Niklas Eberhardt,
  Mischa Elkner, Tamás Hausel, Andres Fernandez Herrero, Adeel Khan,\r\nBernhard Köck,
  Andrei Konovalov, Quoc Ho, Mirko Mauri, Matthew Morrow, Charanya\r\nRavi, Kamil
  Rychlewicz, Shyiu Shen, Vladimir Sosnilo, Georg Tamme, Xinwen Zhu. I\r\nwould further
  like to thank Marc Hoyois and the anonymous referee for spotting an error\r\nin
  a previous version.\r\nThis work was done during author’s PhD at the Institute of
  Science and Technology Austria (ISTA). It was funded by a DOC Fellowship of the
  Austrian Academy\r\nof Sciences and by the Austrian Science Fund (FWF) 10.55776/P35847.
  For open access\r\npurposes, the author has applied a CC BY public copyright license
  to any author-accepted\r\nmanuscript version arising from this submission."
article_processing_charge: Yes (in subscription journal)
article_type: original
arxiv: 1
author:
- first_name: Jakub
  full_name: Löwit, Jakub
  id: e3b80ae2-eb8e-11eb-b029-9aef4a9108a0
  last_name: Löwit
citation:
  ama: Löwit J. Equivariant K-theory, affine Grassmannian and perfection. <i>Documenta
    Mathematica</i>. 2026. doi:<a href="https://doi.org/10.4171/dm/1064">10.4171/dm/1064</a>
  apa: Löwit, J. (2026). Equivariant K-theory, affine Grassmannian and perfection.
    <i>Documenta Mathematica</i>. EMS Press. <a href="https://doi.org/10.4171/dm/1064">https://doi.org/10.4171/dm/1064</a>
  chicago: Löwit, Jakub. “Equivariant K-Theory, Affine Grassmannian and Perfection.”
    <i>Documenta Mathematica</i>. EMS Press, 2026. <a href="https://doi.org/10.4171/dm/1064">https://doi.org/10.4171/dm/1064</a>.
  ieee: J. Löwit, “Equivariant K-theory, affine Grassmannian and perfection,” <i>Documenta
    Mathematica</i>. EMS Press, 2026.
  ista: Löwit J. 2026. Equivariant K-theory, affine Grassmannian and perfection. Documenta
    Mathematica.
  mla: Löwit, Jakub. “Equivariant K-Theory, Affine Grassmannian and Perfection.” <i>Documenta
    Mathematica</i>, EMS Press, 2026, doi:<a href="https://doi.org/10.4171/dm/1064">10.4171/dm/1064</a>.
  short: J. Löwit, Documenta Mathematica (2026).
corr_author: '1'
das_tickbox: '0'
date_created: 2026-08-12T13:29:17Z
date_published: 2026-03-26T00:00:00Z
date_updated: 2026-08-26T06:53:54Z
day: '26'
ddc:
- '500'
department:
- _id: GradSch
- _id: TaHa
doi: 10.4171/dm/1064
external_id:
  arxiv:
  - '2409.18925'
fulldoi: https://doi.org/10.4171/dm/1064
has_accepted_license: '1'
keyword:
- equivariant algebraic K-theory
- perfection in positive characteristic
- affine Grassmannian
- affine Schubert varieties
- Dennis trace map
- equivariant Hochschild homology
- fixed-point schemes
- toric varieties
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.4171/DM/1064
mathsc:
- '19E08'
- 19L47
- 20G44
- 14G17
- 19D55
- 14F43
- 14L30
- 14D24
- 14M25
month: '03'
oa: 1
oa_version: Published Version
project:
- _id: 34b2c9cb-11ca-11ed-8bc3-a50ba74ca4a3
  grant_number: P35847
  name: Geometry of the tip of the global nilpotent cone
publication: Documenta Mathematica
publication_identifier:
  eissn:
  - 1431-0643
  issn:
  - 1431-0635
publication_status: epub_ahead
publisher: EMS Press
quality_controlled: '1'
related_material:
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researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Equivariant K-theory, affine Grassmannian and perfection
tmp:
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type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_type: closed access
_id: '21762'
abstract:
- lang: eng
  text: Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular
    organization. The plasmid-encoded ParMRC system forms actin-like filaments that
    segregate low–copy number plasmids. In multicellular cyanobacteria such as Anabaena
    sp., we found that a chromosomally encoded ParMR system has evolved into a cytoskeletal
    system named CorMR with a function in cell shape control rather than DNA segregation.
    Live-cell imaging, in vitro reconstitution, and cryo–electron microscopy revealed
    that CorM formed dynamically unstable, antiparallel double-stranded filaments
    that were recruited to the membrane by CorR through an amphipathic helix conserved
    in multicellular cyanobacteria. CorMR filaments were regulated by MinC, which
    excluded them from the poles and division plane. Comparative genomics indicated
    that the repurposing of ParMR and Min systems coevolved with cyanobacterial multicellularity,
    highlighting the evolutionary plasticity of cytoskeletal systems in bacteria.
acknowledged_ssus:
- _id: Bio
- _id: ScienComp
- _id: EM-Fac
- _id: LifeSc
acknowledgement: "We thank all members of the Loose lab at ISTA for helpful discussions;
  M. Kojic for critical reading of the manuscript; A. Herrero (Sevilla University)
  for sharing her extensive BACTH plasmid library and other plasmids, as well as cyanobacterial
  strains; T. Dagan and F. Nies (both Kiel University) for sharing cyanobacterial
  strains and plasmids and for valuable discussions; N. Sapay and A. Michon for providing
  the Amphipaseek code, which enabled us to perform our large-scale amphipathic helix
  screen of cyanobacterial CorR proteins; V.-V. Hodirnau for support in cryo-ET data
  collection; and J. Hansen for advice about cryo-EM data processing.\r\nThis work
  was supported by the Scientific Service Units (SSU) of ISTA through resources provided
  by the Imaging & Optics Facility (IOF), the Scientific Computing (SciComp), the
  Electron Microscopy Facility (EMF), and the Lab Support Facility (LSF). This work
  was funded by the European Union’s Horizon 2020 research and innovation program
  (Marie Skłodowska-Curie grant 101034413 to B.L.S.); the European Research Council
  (ERC) of the European Union (grant ActinID 101076260 to F.K.M.S.); the Swiss National
  Science Foundation (starting grant TMSGI3_226208 to G.L.W.); and the Jean-Jacques
  et Letitia Lopez-Loreta Foundation (G.L.W.)."
article_number: eaea6343
article_processing_charge: No
article_type: original
author:
- first_name: Benjamin L
  full_name: Springstein, Benjamin L
  id: b4eb62ef-ac72-11ed-9503-ed3b4d66c083
  last_name: Springstein
  orcid: 0000-0002-3461-5391
- first_name: Manjunath
  full_name: Javoor, Manjunath
  id: 305ab18b-dc7d-11ea-9b2f-b58195228ea2
  last_name: Javoor
  orcid: 0000-0003-2311-2112
- first_name: Daniela
  full_name: Megrian, Daniela
  last_name: Megrian
- first_name: Roman
  full_name: Hajdu, Roman
  id: ffab949d-133f-11ed-8f02-94de21ace503
  last_name: Hajdu
- first_name: Dustin M.
  full_name: Hanke, Dustin M.
  last_name: Hanke
- first_name: Bettina
  full_name: Zens, Bettina
  id: 45FD126C-F248-11E8-B48F-1D18A9856A87
  last_name: Zens
  orcid: 0000-0002-9561-1239
- first_name: Gregor L.
  full_name: Weiss, Gregor L.
  last_name: Weiss
- first_name: Florian Km
  full_name: Schur, Florian Km
  id: 48AD8942-F248-11E8-B48F-1D18A9856A87
  last_name: Schur
  orcid: 0000-0003-4790-8078
- first_name: Martin
  full_name: Loose, Martin
  id: 462D4284-F248-11E8-B48F-1D18A9856A87
  last_name: Loose
  orcid: 0000-0001-7309-9724
citation:
  ama: Springstein BL, Javoor M, Megrian D, et al. Repurposing of a DNA segregation
    machinery into a cytoskeletal system controlling cell shape. <i>Science</i>. 2026;392(6795).
    doi:<a href="https://doi.org/10.1126/science.aea6343">10.1126/science.aea6343</a>
  apa: Springstein, B. L., Javoor, M., Megrian, D., Hajdu, R., Hanke, D. M., Zens,
    B., … Loose, M. (2026). Repurposing of a DNA segregation machinery into a cytoskeletal
    system controlling cell shape. <i>Science</i>. AAAS. <a href="https://doi.org/10.1126/science.aea6343">https://doi.org/10.1126/science.aea6343</a>
  chicago: Springstein, Benjamin L, Manjunath Javoor, Daniela Megrian, Roman Hajdu,
    Dustin M. Hanke, Bettina Zens, Gregor L. Weiss, Florian KM Schur, and Martin Loose.
    “Repurposing of a DNA Segregation Machinery into a Cytoskeletal System Controlling
    Cell Shape.” <i>Science</i>. AAAS, 2026. <a href="https://doi.org/10.1126/science.aea6343">https://doi.org/10.1126/science.aea6343</a>.
  ieee: B. L. Springstein <i>et al.</i>, “Repurposing of a DNA segregation machinery
    into a cytoskeletal system controlling cell shape,” <i>Science</i>, vol. 392,
    no. 6795. AAAS, 2026.
  ista: Springstein BL, Javoor M, Megrian D, Hajdu R, Hanke DM, Zens B, Weiss GL,
    Schur FK, Loose M. 2026. Repurposing of a DNA segregation machinery into a cytoskeletal
    system controlling cell shape. Science. 392(6795), eaea6343.
  mla: Springstein, Benjamin L., et al. “Repurposing of a DNA Segregation Machinery
    into a Cytoskeletal System Controlling Cell Shape.” <i>Science</i>, vol. 392,
    no. 6795, eaea6343, AAAS, 2026, doi:<a href="https://doi.org/10.1126/science.aea6343">10.1126/science.aea6343</a>.
  short: B.L. Springstein, M. Javoor, D. Megrian, R. Hajdu, D.M. Hanke, B. Zens, G.L.
    Weiss, F.K. Schur, M. Loose, Science 392 (2026).
corr_author: '1'
date_created: 2026-04-26T22:01:46Z
date_published: 2026-04-16T00:00:00Z
date_updated: 2026-09-03T09:36:24Z
day: '16'
department:
- _id: MaLo
- _id: FlSc
- _id: GradSch
- _id: EM-Fac
doi: 10.1126/science.aea6343
ec_funded: 1
external_id:
  pmid:
  - '41990175'
fulldoi: https://doi.org/10.1126/science.aea6343
intvolume: '       392'
issue: '6795'
language:
- iso: eng
month: '04'
oa_version: None
pmid: 1
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
- _id: bd980d18-d553-11ed-ba76-ceaa645c97eb
  grant_number: '101076260'
  name: A molecular atlas of Actin filament IDentities in the cell motility machinery
publication: Science
publication_identifier:
  eissn:
  - 1095-9203
  issn:
  - 0036-8075
publication_status: published
publisher: AAAS
quality_controlled: '1'
related_material:
  record:
  - id: '22744'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Repurposing of a DNA segregation machinery into a cytoskeletal system controlling
  cell shape
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 392
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22751'
abstract:
- lang: eng
  text: 'The physical processes that led to the formation of billion-solar-mass black
    holes within the first 700 million years of cosmic time, a period known as cosmic
    dawn, remain a puzzle1. Several theoretical scenarios have been proposed to seed
    and rapidly grow black holes2,3,4, but direct observations of these mechanisms
    remain elusive. Here we present a source 660 million years after the Big Bang
    that exhibits singular properties: among the largest hydrogen Balmer breaks reported
    at any redshift, broad multi-peaked Hβ emission, and Balmer line absorption in
    several transitions. We model this source as an enshrouded black hole in which
    the Balmer break and absorption features are a result of extremely dense, turbulent
    gas forming a dust-free envelope around a supermassive black hole5,6. This source
    may provide evidence of an early black hole embedded in dense gas—a theoretical
    configuration proposed to rapidly grow black holes by super-Eddington accretion7,8.
    Radiation from the black hole seems to dominate almost all observed light, leaving
    limited room for contribution from its host galaxy. If the source merged with
    its brighter neighbour, it would resemble the recently discovered ‘little red
    dots’ with perplexing spectral energy distributions9,10,11. The redness of the
    black hole is due to gas, not dust12,13, and scattering, not kinematics, gives
    rise to the complex line shapes and luminosities—black hole masses of these sources
    may therefore be overestimated by orders of magnitude.'
acknowledgement: This work is based on observations made with the NASA/ESA/CSA James
  Webb Space Telescope. The data were obtained from the Mikulski Archive for Space
  Telescopes at the Space Telescope Science Institute, which is operated by the Association
  of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127
  for JWST. These observations are associated with programs 5224 and 3543. R.P.N.
  is a NASA Hubble Fellow. D.J.S. is a Brinson Prize Fellow. Some of the data products
  presented in this study were retrieved from the DJA. DJA is an initiative of the
  Cosmic Dawn Center (DAWN), which is funded by the Danish National Research Foundation
  under grant DNRF140. We acknowledge funding from JWST programmes GO-3516, GO-5224
  and GO-1837. Support for this work was provided by NASA through the NASA Hubble
  Fellowship grant HST-HF2-51515.001-A awarded by the Space Telescope Science Institute,
  which is operated by the Association of Universities for Research in Astronomy,
  Incorporated, under NASA contract NAS5-26555. Funded by the European Union (ERC
  AGENTS, 101076224; HEAVYMETAL, 101071865; RED CARDINAL, 101076080). Views and opinions
  expressed are however those of the author(s) only and do not necessarily reflect
  those of the European Union or the European Research Council. Neither the European
  Union nor the granting authority can be held responsible for them. This work has
  received funding from the Swiss State Secretariat for Education, Research and Innovation
  (SERI) under contract number MB22.00072, as well as from the Swiss National Science
  Foundation (SNSF) through project grant 200020_207349. This work was also supported
  by JSPS KAKENHI grant no. 23H00131. The Cosmic Dawn Center is funded by the Danish
  National Research Foundation under grant DNRF140. P.N. acknowledges support from
  the Gordon and Betty Moore Foundation and the John Templeton Foundation that fund
  the Black Hole Initiative (BHI) at Harvard University, where she serves as an external
  prinicpal investigator. S. Bose acknowledges funding from a UK Research and Innovation
  (UKRI) Future Leaders Fellowship (grant no. MR/V023381/1).
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Rohan P.
  full_name: Naidu, Rohan P.
  last_name: Naidu
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
- first_name: Harley
  full_name: Katz, Harley
  last_name: Katz
- first_name: Anna
  full_name: De Graaff, Anna
  last_name: De Graaff
- first_name: Pascal A.
  full_name: Oesch, Pascal A.
  last_name: Oesch
- first_name: Aaron
  full_name: Smith, Aaron
  last_name: Smith
- first_name: Jenny E.
  full_name: Greene, Jenny E.
  last_name: Greene
- first_name: Gabriel
  full_name: Brammer, Gabriel
  last_name: Brammer
- first_name: Andrea
  full_name: Weibel, Andrea
  last_name: Weibel
- first_name: Raphael
  full_name: Hviding, Raphael
  last_name: Hviding
- first_name: John
  full_name: Chisholm, John
  last_name: Chisholm
- first_name: Ivo
  full_name: Labbé, Ivo
  last_name: Labbé
- first_name: Robert A.
  full_name: Simcoe, Robert A.
  last_name: Simcoe
- first_name: Callum
  full_name: Witten, Callum
  last_name: Witten
- first_name: Wendy Q.
  full_name: Sun, Wendy Q.
  last_name: Sun
- first_name: Hakim
  full_name: Atek, Hakim
  last_name: Atek
- first_name: Josephine F.W.
  full_name: Baggen, Josephine F.W.
  last_name: Baggen
- first_name: Sirio
  full_name: Belli, Sirio
  last_name: Belli
- first_name: Rachel
  full_name: Bezanson, Rachel
  last_name: Bezanson
- first_name: Leindert A.
  full_name: Boogaard, Leindert A.
  last_name: Boogaard
- first_name: Sownak
  full_name: Bose, Sownak
  last_name: Bose
- first_name: Rychard J.
  full_name: Bouwens, Rychard J.
  last_name: Bouwens
- first_name: Alba
  full_name: Covelo-Paz, Alba
  last_name: Covelo-Paz
- first_name: Pratika
  full_name: Dayal, Pratika
  last_name: Dayal
- first_name: Yoshinobu
  full_name: Fudamoto, Yoshinobu
  last_name: Fudamoto
- first_name: Lukas J.
  full_name: Furtak, Lukas J.
  last_name: Furtak
- first_name: Emma
  full_name: Giovinazzo, Emma
  last_name: Giovinazzo
- first_name: Andy
  full_name: Goulding, Andy
  last_name: Goulding
- first_name: Max
  full_name: Gronke, Max
  last_name: Gronke
- first_name: Kasper E.
  full_name: Heintz, Kasper E.
  last_name: Heintz
- first_name: Michaela
  full_name: Hirschmann, Michaela
  last_name: Hirschmann
- first_name: Garth
  full_name: Illingworth, Garth
  last_name: Illingworth
- first_name: Akio K.
  full_name: Inoue, Akio K.
  last_name: Inoue
- first_name: Benjamin D.
  full_name: Johnson, Benjamin D.
  last_name: Johnson
- first_name: Joel
  full_name: Leja, Joel
  last_name: Leja
- first_name: Ecaterina
  full_name: Leonova, Ecaterina
  last_name: Leonova
- first_name: Ian
  full_name: Mcconachie, Ian
  last_name: Mcconachie
- first_name: Michael V.
  full_name: Maseda, Michael V.
  last_name: Maseda
- first_name: Priyamvada
  full_name: Natarajan, Priyamvada
  last_name: Natarajan
- first_name: Erica
  full_name: Nelson, Erica
  last_name: Nelson
- first_name: David J.
  full_name: Setton, David J.
  last_name: Setton
- first_name: Irene
  full_name: Shivaei, Irene
  last_name: Shivaei
- first_name: David
  full_name: Sobral, David
  last_name: Sobral
- first_name: Mauro
  full_name: Stefanon, Mauro
  last_name: Stefanon
- first_name: Sandro
  full_name: Tacchella, Sandro
  last_name: Tacchella
- first_name: Sune
  full_name: Toft, Sune
  last_name: Toft
- first_name: Alberto
  full_name: Torralba Torregrosa, Alberto
  id: 018f0249-0e87-11f0-b167-cbce08fbd541
  last_name: Torralba Torregrosa
  orcid: 0000-0001-5586-6950
- first_name: Pieter
  full_name: Van Dokkum, Pieter
  last_name: Van Dokkum
- first_name: Arjen
  full_name: Van Der Wel, Arjen
  last_name: Van Der Wel
- first_name: Marta
  full_name: Volonteri, Marta
  last_name: Volonteri
- first_name: Fabian
  full_name: Walter, Fabian
  last_name: Walter
- first_name: Bingjie
  full_name: Wang, Bingjie
  last_name: Wang
- first_name: Darach
  full_name: Watson, Darach
  last_name: Watson
- first_name: Katherine
  full_name: Whitaker, Katherine
  last_name: Whitaker
citation:
  ama: Naidu RP, Matthee JJ, Katz H, et al. A gas-enshrouded and gas-reddened black
    hole at cosmic dawn. <i>Nature</i>. 2026;656(8127):329-333. doi:<a href="https://doi.org/10.1038/s41586-026-10846-4">10.1038/s41586-026-10846-4</a>
  apa: Naidu, R. P., Matthee, J. J., Katz, H., De Graaff, A., Oesch, P. A., Smith,
    A., … Whitaker, K. (2026). A gas-enshrouded and gas-reddened black hole at cosmic
    dawn. <i>Nature</i>. Springer Nature. <a href="https://doi.org/10.1038/s41586-026-10846-4">https://doi.org/10.1038/s41586-026-10846-4</a>
  chicago: Naidu, Rohan P., Jorryt J Matthee, Harley Katz, Anna De Graaff, Pascal
    A. Oesch, Aaron Smith, Jenny E. Greene, et al. “A Gas-Enshrouded and Gas-Reddened
    Black Hole at Cosmic Dawn.” <i>Nature</i>. Springer Nature, 2026. <a href="https://doi.org/10.1038/s41586-026-10846-4">https://doi.org/10.1038/s41586-026-10846-4</a>.
  ieee: R. P. Naidu <i>et al.</i>, “A gas-enshrouded and gas-reddened black hole at
    cosmic dawn,” <i>Nature</i>, vol. 656, no. 8127. Springer Nature, pp. 329–333,
    2026.
  ista: Naidu RP, Matthee JJ, Katz H, De Graaff A, Oesch PA, Smith A, Greene JE, Brammer
    G, Weibel A, Hviding R, Chisholm J, Labbé I, Simcoe RA, Witten C, Sun WQ, Atek
    H, Baggen JFW, Belli S, Bezanson R, Boogaard LA, Bose S, Bouwens RJ, Covelo-Paz
    A, Dayal P, Fudamoto Y, Furtak LJ, Giovinazzo E, Goulding A, Gronke M, Heintz
    KE, Hirschmann M, Illingworth G, Inoue AK, Johnson BD, Leja J, Leonova E, Mcconachie
    I, Maseda MV, Natarajan P, Nelson E, Setton DJ, Shivaei I, Sobral D, Stefanon
    M, Tacchella S, Toft S, Torralba Torregrosa A, Van Dokkum P, Van Der Wel A, Volonteri
    M, Walter F, Wang B, Watson D, Whitaker K. 2026. A gas-enshrouded and gas-reddened
    black hole at cosmic dawn. Nature. 656(8127), 329–333.
  mla: Naidu, Rohan P., et al. “A Gas-Enshrouded and Gas-Reddened Black Hole at Cosmic
    Dawn.” <i>Nature</i>, vol. 656, no. 8127, Springer Nature, 2026, pp. 329–33, doi:<a
    href="https://doi.org/10.1038/s41586-026-10846-4">10.1038/s41586-026-10846-4</a>.
  short: R.P. Naidu, J.J. Matthee, H. Katz, A. De Graaff, P.A. Oesch, A. Smith, J.E.
    Greene, G. Brammer, A. Weibel, R. Hviding, J. Chisholm, I. Labbé, R.A. Simcoe,
    C. Witten, W.Q. Sun, H. Atek, J.F.W. Baggen, S. Belli, R. Bezanson, L.A. Boogaard,
    S. Bose, R.J. Bouwens, A. Covelo-Paz, P. Dayal, Y. Fudamoto, L.J. Furtak, E. Giovinazzo,
    A. Goulding, M. Gronke, K.E. Heintz, M. Hirschmann, G. Illingworth, A.K. Inoue,
    B.D. Johnson, J. Leja, E. Leonova, I. Mcconachie, M.V. Maseda, P. Natarajan, E.
    Nelson, D.J. Setton, I. Shivaei, D. Sobral, M. Stefanon, S. Tacchella, S. Toft,
    A. Torralba Torregrosa, P. Van Dokkum, A. Van Der Wel, M. Volonteri, F. Walter,
    B. Wang, D. Watson, K. Whitaker, Nature 656 (2026) 329–333.
das_tickbox: '1'
dataavailabilitystatement: 'The prism spectra obtained as part of JWST-GO-5224 (MoM)
  featured in this work are available on Zenodo (https://doi.org/10.5281/zenodo.15059214).
  All processed images and spectra used in this work are publicly available via the
  DAWN JWST archive (https://dawn-cph.github.io/dja/). All results presented may be
  reproduced with the open-access reduced data described above and using the following
  publicly available software whose use is referenced in the text: msaexp, grizli,
  astropy, Cloudy, SpectRes, pysersic, COLT and numpyro.'
date_created: 2026-08-23T22:01:46Z
date_published: 2026-08-13T00:00:00Z
date_updated: 2026-09-07T12:50:34Z
day: '13'
ddc:
- '520'
department:
- _id: JoMa
doi: 10.1038/s41586-026-10846-4
external_id:
  pmid:
  - '42587117'
file:
- access_level: open_access
  checksum: 80127691cb39deb39948c337f6915f7b
  content_type: application/pdf
  creator: dernst
  date_created: 2026-09-07T12:49:32Z
  date_updated: 2026-09-07T12:49:32Z
  file_id: '22841'
  file_name: 2026_Nature_Naidu.pdf
  file_size: 15134062
  relation: main_file
  success: 1
file_date_updated: 2026-09-07T12:49:32Z
fulldoi: https://doi.org/10.1038/s41586-026-10846-4
has_accepted_license: '1'
intvolume: '       656'
issue: '8127'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 329-333
pmid: 1
publication: Nature
publication_identifier:
  eissn:
  - 1476-4687
  issn:
  - 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: A gas-enshrouded and gas-reddened black hole at cosmic dawn
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 656
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '22750'
abstract:
- lang: eng
  text: 'Robust oxygenic photosynthesis requires the efficient assembly and repair
    of the multi-subunit oxygen-evolving photosystem II (PSII) complex. Previous cryogenic
    electron microscopy (cryo-EM) structures of PSII assembly/disassembly intermediates
    have relied on the analysis of deletion mutants or removal of PSII subunits in
    vitro. Here we report the cryo-EM structures of naturally occurring dimeric PSII
    intermediates from the cyanobacterium Thermosynechococcus vestitus at a resolution
    of about 2.2 Å. These intermediates contain inactive dimers lacking the oxygen-evolving
    complex (OEC) and semi-active dimers with the OEC present in one of the two monomers.
    Our structural data provide a mechanism for how assembly and disassembly of the
    Mn4CaO5 cluster is coordinated with the binding and release of the extrinsic proteins:
    restructuring of the C-terminal tail of D1 subunit during assembly or disassembly
    of the Mn cluster triggers conformational changes in D2, CP47 and CP43 to drive
    the binding/release of the extrinsic proteins. A combination of structural and
    mass spectrometry data also suggests that the inactive PSII complexes may include
    damaged complexes containing oxidized D1-His332, a monodentate ligand to one of
    the Mn ions of the OEC.'
acknowledged_ssus:
- _id: EM-Fac
- _id: LifeSc
- _id: ScienComp
acknowledgement: 'P.J.N. is grateful for the support from the Imperial College Electron
  Microscopy Center. L.A.S. acknowledges the support from the Scientific Service Units
  (SSU) of IST Austria: the Electron Microscopy Facility (EMF), the Life Science Facility
  (LSF) and the IST high-performance computing cluster. P.J.N. is grateful for the
  support of the Biotechnology & Biological Sciences Research Council (awards BB/I00937X/1,
  BB/L003260/1 and BB/P00931X/1). L.A.S. is grateful to IST Austria for providing
  the funding.'
article_number: '8433'
article_processing_charge: Yes
article_type: original
author:
- first_name: Ziyu
  full_name: Zhao, Ziyu
  id: a63fe682-9f3a-11ee-bf8c-cfdf919b9850
  last_name: Zhao
- first_name: Irene
  full_name: Vercellino, Irene
  id: 3ED6AF16-F248-11E8-B48F-1D18A9856A87
  last_name: Vercellino
  orcid: 0000-0001-5618-3449
- first_name: Julian P.
  full_name: Whitelegge, Julian P.
  last_name: Whitelegge
- first_name: Karim
  full_name: Maghlaoui, Karim
  last_name: Maghlaoui
- first_name: Wojciech
  full_name: Białek, Wojciech
  last_name: Białek
- first_name: Peter J.
  full_name: Nixon, Peter J.
  last_name: Nixon
- first_name: Leonid A
  full_name: Sazanov, Leonid A
  id: 338D39FE-F248-11E8-B48F-1D18A9856A87
  last_name: Sazanov
  orcid: 0000-0002-0977-7989
citation:
  ama: Zhao Z, Vercellino I, Whitelegge JP, et al. Cryo-EM structures of naturally
    occurring dimeric photosystem II complexes lacking the Mn4CaO5 cluster. <i>Nature
    Communications</i>. 2026;17. doi:<a href="https://doi.org/10.1038/s41467-026-75324-x">10.1038/s41467-026-75324-x</a>
  apa: Zhao, Z., Vercellino, I., Whitelegge, J. P., Maghlaoui, K., Białek, W., Nixon,
    P. J., &#38; Sazanov, L. A. (2026). Cryo-EM structures of naturally occurring
    dimeric photosystem II complexes lacking the Mn4CaO5 cluster. <i>Nature Communications</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41467-026-75324-x">https://doi.org/10.1038/s41467-026-75324-x</a>
  chicago: Zhao, Ziyu, Irene Vercellino, Julian P. Whitelegge, Karim Maghlaoui, Wojciech
    Białek, Peter J. Nixon, and Leonid A Sazanov. “Cryo-EM Structures of Naturally
    Occurring Dimeric Photosystem II Complexes Lacking the Mn4CaO5 Cluster.” <i>Nature
    Communications</i>. Springer Nature, 2026. <a href="https://doi.org/10.1038/s41467-026-75324-x">https://doi.org/10.1038/s41467-026-75324-x</a>.
  ieee: Z. Zhao <i>et al.</i>, “Cryo-EM structures of naturally occurring dimeric
    photosystem II complexes lacking the Mn4CaO5 cluster,” <i>Nature Communications</i>,
    vol. 17. Springer Nature, 2026.
  ista: Zhao Z, Vercellino I, Whitelegge JP, Maghlaoui K, Białek W, Nixon PJ, Sazanov
    LA. 2026. Cryo-EM structures of naturally occurring dimeric photosystem II complexes
    lacking the Mn4CaO5 cluster. Nature Communications. 17, 8433.
  mla: Zhao, Ziyu, et al. “Cryo-EM Structures of Naturally Occurring Dimeric Photosystem
    II Complexes Lacking the Mn4CaO5 Cluster.” <i>Nature Communications</i>, vol.
    17, 8433, Springer Nature, 2026, doi:<a href="https://doi.org/10.1038/s41467-026-75324-x">10.1038/s41467-026-75324-x</a>.
  short: Z. Zhao, I. Vercellino, J.P. Whitelegge, K. Maghlaoui, W. Białek, P.J. Nixon,
    L.A. Sazanov, Nature Communications 17 (2026).
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: The cryo-EM maps are deposited in the Electron Microscopy
  Data Bank under accession number EMD- 51100 (inactive dimer), EMD- 51102 (active
  dimer) and EMD-51101 (semi-active dimer). The models are deposited in the Protein
  Data Bank under accession numbers 9G6F (inactive dimer), 9G6H (active dimer) and
  9G6G (semi-active dimer). Mass spectrometry data was uploaded to MassIVE with accession
  code MSV000101057. Source data are provided with this paper.
date_created: 2026-08-23T22:01:46Z
date_published: 2026-08-17T00:00:00Z
date_updated: 2026-09-07T13:17:53Z
day: '17'
ddc:
- '570'
department:
- _id: LeSa
doi: 10.1038/s41467-026-75324-x
external_id:
  pmid:
  - '42420307'
file:
- access_level: open_access
  checksum: a820b736585de22bcfa30ebdd25a6dd2
  content_type: application/pdf
  creator: dernst
  date_created: 2026-09-07T13:13:03Z
  date_updated: 2026-09-07T13:13:03Z
  file_id: '22843'
  file_name: 2026_NatureComm_Zhao.pdf
  file_size: 3370665
  relation: main_file
  success: 1
file_date_updated: 2026-09-07T13:13:03Z
fulldoi: https://doi.org/10.1038/s41467-026-75324-x
has_accepted_license: '1'
intvolume: '        17'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Cryo-EM structures of naturally occurring dimeric photosystem II complexes
  lacking the Mn4CaO5 cluster
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22752'
abstract:
- lang: eng
  text: "In this note we outline a new and simple approach to proving central limit
    theorems for various ‘global’ graph parameters that have robust ‘local’ approximations,
    using the Efron–Stein inequality, which relies on a combinatorial analysis of
    the stability of these approximations under resampling an edge. As an application,
    we give short proofs of a central limit theorem for the order of the giant component
    and of the \U0001D458\r\n-core for sparse random graphs."
acknowledgement: This research was funded in whole or in part by the Austrian Science
  Fund (FWF) [10.55776/P36131 (Joshua Erde), 10.55776/I6502 (Mihyun Kang), 10.55776/ESP3863424
  (Michael Anastos)] and by the Swiss National Science Foundation (SNSF) [P500-2_235474]
  (Vincent Pfenninger). For open access purposes, the authors have applied a CC BY
  public copyright license to any author accepted manuscript version arising from
  this submission. The authors thank the reviewers for helpful comments on the paper,
  and for bringing the particular form of Theorem 2.2 to our attention.
article_number: e70464
article_processing_charge: Yes (in subscription journal)
article_type: original
arxiv: 1
author:
- first_name: Michael
  full_name: Anastos, Michael
  id: 0b2a4358-bb35-11ec-b7b9-e3279b593dbb
  last_name: Anastos
- first_name: Joshua
  full_name: Erde, Joshua
  last_name: Erde
- first_name: Mihyun
  full_name: Kang, Mihyun
  last_name: Kang
- first_name: Vincent
  full_name: Pfenninger, Vincent
  last_name: Pfenninger
citation:
  ama: Anastos M, Erde J, Kang M, Pfenninger V. A short proof of a central limit theorem
    for the order of the giant component and k-core. <i>Bulletin of the London Mathematical
    Society</i>. 2026;58(8). doi:<a href="https://doi.org/10.1112/blms.70464">10.1112/blms.70464</a>
  apa: Anastos, M., Erde, J., Kang, M., &#38; Pfenninger, V. (2026). A short proof
    of a central limit theorem for the order of the giant component and k-core. <i>Bulletin
    of the London Mathematical Society</i>. Wiley. <a href="https://doi.org/10.1112/blms.70464">https://doi.org/10.1112/blms.70464</a>
  chicago: Anastos, Michael, Joshua Erde, Mihyun Kang, and Vincent Pfenninger. “A
    Short Proof of a Central Limit Theorem for the Order of the Giant Component and
    K-Core.” <i>Bulletin of the London Mathematical Society</i>. Wiley, 2026. <a href="https://doi.org/10.1112/blms.70464">https://doi.org/10.1112/blms.70464</a>.
  ieee: M. Anastos, J. Erde, M. Kang, and V. Pfenninger, “A short proof of a central
    limit theorem for the order of the giant component and k-core,” <i>Bulletin of
    the London Mathematical Society</i>, vol. 58, no. 8. Wiley, 2026.
  ista: Anastos M, Erde J, Kang M, Pfenninger V. 2026. A short proof of a central
    limit theorem for the order of the giant component and k-core. Bulletin of the
    London Mathematical Society. 58(8), e70464.
  mla: Anastos, Michael, et al. “A Short Proof of a Central Limit Theorem for the
    Order of the Giant Component and K-Core.” <i>Bulletin of the London Mathematical
    Society</i>, vol. 58, no. 8, e70464, Wiley, 2026, doi:<a href="https://doi.org/10.1112/blms.70464">10.1112/blms.70464</a>.
  short: M. Anastos, J. Erde, M. Kang, V. Pfenninger, Bulletin of the London Mathematical
    Society 58 (2026).
das_tickbox: '0'
date_created: 2026-08-23T22:01:47Z
date_published: 2026-08-01T00:00:00Z
date_updated: 2026-09-07T13:56:17Z
day: '01'
ddc:
- '510'
department:
- _id: MaKw
doi: 10.1112/blms.70464
external_id:
  arxiv:
  - '2506.11651'
file:
- access_level: open_access
  checksum: b4b21f05c3fc62fde243a5ddd46cef49
  content_type: application/pdf
  creator: dernst
  date_created: 2026-09-07T13:53:26Z
  date_updated: 2026-09-07T13:53:26Z
  file_id: '22845'
  file_name: 2026_BulletinLondonMathSoc_Anastos.pdf
  file_size: 248641
  relation: main_file
  success: 1
file_date_updated: 2026-09-07T13:53:26Z
fulldoi: https://doi.org/10.1112/blms.70464
has_accepted_license: '1'
intvolume: '        58'
issue: '8'
language:
- iso: eng
mathsc:
- 05C80
- 60F05
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 8f906bd2-16d5-11f0-9cad-e07be8aa9ac9
  grant_number: ESP3863424
  name: Combinatorial Optimisation Problems on Sparse Random Graphs
publication: Bulletin of the London Mathematical Society
publication_identifier:
  eissn:
  - 1469-2120
  issn:
  - 0024-6093
publication_status: published
publisher: Wiley
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: A short proof of a central limit theorem for the order of the giant component
  and k-core
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 58
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '22754'
abstract:
- lang: eng
  text: "Quantitative automata (QAs) extend finite-state automata on infinite words
    with weighted transitions to specify quantitative system properties. However,
    their finite weight sets rule out properties like average response time, where
    response times can be arbitrarily large. Nested quantitative automata (NQAs) overcome
    this limitation: a parent automaton spawns child automata to compute unbounded
    values over finite infixes and aggregates them into a final result. Despite this
    expressiveness, NQAs have lacked practical tool support to date.\r\n\r\nWe close
    this gap by extending the Quantitative Automata Kit (QuAK), a software tool for
    QA analysis, to support NQAs. Our core contribution is implementing a suite of
    flattening procedures that reduce NQAs to QAs, leveraging QuAK’s existing decision
    procedures. These reductions preserve the answers to threshold decision problems,
    while allowing users to specify properties in the more expressive NQA formalism.
    The tool handles all combinations of parent aggregators (including limits and
    averages) and child functions (extrema and monotonic or bounded summations) for
    which emptiness and universality are known to be decidable. Experiments on response-time
    and resource-consumption benchmarks demonstrate QuAK’s effectiveness."
acknowledgement: This work was supported by the European Research Council (ERC) Grants
  VAMOS (No. 101020093) and HYPER (No. 101055412).
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000-0002-2985-7724
- first_name: Nicolas Adrien
  full_name: Mazzocchi, Nicolas Adrien
  id: b26baa86-3308-11ec-87b0-8990f34baa85
  last_name: Mazzocchi
- first_name: Naci E
  full_name: Sarac, Naci E
  id: 8C6B42F8-C8E6-11E9-A03A-F2DCE5697425
  last_name: Sarac
- first_name: Harun
  full_name: Yılmaz, Harun
  last_name: Yılmaz
citation:
  ama: 'Henzinger TA, Mazzocchi NA, Sarac NE, Yılmaz H. Extending QuAK with nested
    quantitative automata. In: <i>38th International Conference on Computer Aided
    Verification</i>. Vol 16683. Springer Nature; 2026:418-432. doi:<a href="https://doi.org/10.1007/978-3-032-32526-6_20">10.1007/978-3-032-32526-6_20</a>'
  apa: 'Henzinger, T. A., Mazzocchi, N. A., Sarac, N. E., &#38; Yılmaz, H. (2026).
    Extending QuAK with nested quantitative automata. In <i>38th International Conference
    on Computer Aided Verification</i> (Vol. 16683, pp. 418–432). Lisbon, Portugal:
    Springer Nature. <a href="https://doi.org/10.1007/978-3-032-32526-6_20">https://doi.org/10.1007/978-3-032-32526-6_20</a>'
  chicago: Henzinger, Thomas A, Nicolas Adrien Mazzocchi, Naci E Sarac, and Harun
    Yılmaz. “Extending QuAK with Nested Quantitative Automata.” In <i>38th International
    Conference on Computer Aided Verification</i>, 16683:418–32. Springer Nature,
    2026. <a href="https://doi.org/10.1007/978-3-032-32526-6_20">https://doi.org/10.1007/978-3-032-32526-6_20</a>.
  ieee: T. A. Henzinger, N. A. Mazzocchi, N. E. Sarac, and H. Yılmaz, “Extending QuAK
    with nested quantitative automata,” in <i>38th International Conference on Computer
    Aided Verification</i>, Lisbon, Portugal, 2026, vol. 16683, pp. 418–432.
  ista: 'Henzinger TA, Mazzocchi NA, Sarac NE, Yılmaz H. 2026. Extending QuAK with nested
    quantitative automata. 38th International Conference on Computer Aided Verification.
    CAV: Computer Aided Verification, LNCS, vol. 16683, 418–432.'
  mla: Henzinger, Thomas A., et al. “Extending QuAK with Nested Quantitative Automata.”
    <i>38th International Conference on Computer Aided Verification</i>, vol. 16683,
    Springer Nature, 2026, pp. 418–32, doi:<a href="https://doi.org/10.1007/978-3-032-32526-6_20">10.1007/978-3-032-32526-6_20</a>.
  short: T.A. Henzinger, N.A. Mazzocchi, N.E. Sarac, H. Yılmaz, in:, 38th International
    Conference on Computer Aided Verification, Springer Nature, 2026, pp. 418–432.
conference:
  end_date: 2026-07-29
  location: Lisbon, Portugal
  name: 'CAV: Computer Aided Verification'
  start_date: 2026-07-26
das_tickbox: '1'
dataavailabilitystatement: 'The artifact supporting the experimental results in this
  paper is available in the QuAK repository at https://github.com/ista-vamos/nested-quak.
  It contains the extended QuAK implementation, benchmark generators, example inputs,
  and scripts/logs for reproducing the reported tables. The artifact is intended to
  reproduce the experiments under the setup described in Sect. 4; runtimes may vary
  across machines, and the reported timeout and memory-exhaustion results depend on
  the stated hardware limits. No sensitive or restricted data are used. An archived
  version is available on Zenodo at DOI: http://doi.org/10.5281/zenodo.19844606.'
date_created: 2026-08-23T22:01:47Z
date_published: 2026-01-01T00:00:00Z
date_updated: 2026-09-09T06:37:41Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1007/978-3-032-32526-6_20
ec_funded: 1
external_id:
  arxiv:
  - '2605.12418'
file:
- access_level: open_access
  checksum: 043ba7b83f28d036d5a0e6e70a52cc9a
  content_type: application/pdf
  creator: dernst
  date_created: 2026-09-09T06:33:55Z
  date_updated: 2026-09-09T06:33:55Z
  file_id: '22861'
  file_name: 2026_LNCS_HenzingerT.pdf
  file_size: 425988
  relation: main_file
  success: 1
file_date_updated: 2026-09-09T06:33:55Z
fulldoi: https://doi.org/10.1007/978-3-032-32526-6_20
has_accepted_license: '1'
intvolume: '     16683'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 418-432
project:
- _id: 62781420-2b32-11ec-9570-8d9b63373d4d
  call_identifier: H2020
  grant_number: '101020093'
  name: Vigilant Algorithmic Monitoring of Software
publication: 38th International Conference on Computer Aided Verification
publication_identifier:
  eissn:
  - 1611-3349
  isbn:
  - '9783032325259'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: no
title: Extending QuAK with nested quantitative automata
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16683
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '22755'
abstract:
- lang: eng
  text: The eigenstate thermalization hypothesis (ETH) posits how isolated quantum
    many-body systems thermalize, assuming that individual eigenstates at the same
    energy density have identical expectation values of local observables in the limit
    of large systems. While the ETH apparently holds across a wide range of interacting
    quantum systems, in this work, we show that it may require generalization in the
    presence of thermal first-order phase transitions. We introduce a class of all-to-all
    spin models, featuring first-order thermal phase transitions that stem from two
    distinct local maxima of entropy (two mean-field solutions that we dub “branches”)
    that exchange dominance in the many-body density of states as the energy is varied.
    We argue that, for energies in the vicinity of the thermal phase transition, eigenstate
    expectation values do not need to converge to the same thermal value. The system
    has a regime with coexistence of two classes of eigenstates corresponding to the
    two branches with distinct expectation values at the same energy density and another
    regime with Schrödinger-cat-like eigenstates that are interbranch superpositions;
    these two regimes are separated by an eigenstate phase transition. We propose
    a more general form of the ETH , support our results by semiclassical calculations
    and an exact diagonalization study of a microscopic spin model, and argue that
    the structure of eigenstates in the vicinity of thermal first-order phase transitions
    can be experimentally probed via nonequilibrium dynamics.
acknowledgement: A. A. acknowledges discussions and prior collaboration on related
  topics with Anatoly Dymarsky. M. S. acknowledges Ashwin Vishwanath for introducing
  him to the idea of thermal first-order phase transitions in quantum systems. This
  research was supported in part by Grant No. NSF PHY-2309135 to the Kavli Institute
  for Theoretical Physics (KITP) and by the Erwin Schrödinger International Institute
  for Mathematics and Physics (ESI). O. K. D. acknowledges support from the NSF through
  a grant for ITAMP at Harvard University. D. A. H. was supported in part by NSF QLCI
  Grant No. OMA-2120757.
article_number: '031042'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Maksym
  full_name: Serbyn, Maksym
  id: 47809E7E-F248-11E8-B48F-1D18A9856A87
  last_name: Serbyn
  orcid: 0000-0002-2399-5827
- first_name: Alexander
  full_name: Avdoshkin, Alexander
  last_name: Avdoshkin
- first_name: Oriana K.
  full_name: Diessel, Oriana K.
  last_name: Diessel
- first_name: David A.
  full_name: Huse, David A.
  last_name: Huse
citation:
  ama: Serbyn M, Avdoshkin A, Diessel OK, Huse DA. Eigenstate thermalization in thermal
    first-order phase transitions. <i>Physical Review X</i>. 2026;16(3). doi:<a href="https://doi.org/10.1103/4zs8-7kf4">10.1103/4zs8-7kf4</a>
  apa: Serbyn, M., Avdoshkin, A., Diessel, O. K., &#38; Huse, D. A. (2026). Eigenstate
    thermalization in thermal first-order phase transitions. <i>Physical Review X</i>.
    American Physical Society. <a href="https://doi.org/10.1103/4zs8-7kf4">https://doi.org/10.1103/4zs8-7kf4</a>
  chicago: Serbyn, Maksym, Alexander Avdoshkin, Oriana K. Diessel, and David A. Huse.
    “Eigenstate Thermalization in Thermal First-Order Phase Transitions.” <i>Physical
    Review X</i>. American Physical Society, 2026. <a href="https://doi.org/10.1103/4zs8-7kf4">https://doi.org/10.1103/4zs8-7kf4</a>.
  ieee: M. Serbyn, A. Avdoshkin, O. K. Diessel, and D. A. Huse, “Eigenstate thermalization
    in thermal first-order phase transitions,” <i>Physical Review X</i>, vol. 16,
    no. 3. American Physical Society, 2026.
  ista: Serbyn M, Avdoshkin A, Diessel OK, Huse DA. 2026. Eigenstate thermalization
    in thermal first-order phase transitions. Physical Review X. 16(3), 031042.
  mla: Serbyn, Maksym, et al. “Eigenstate Thermalization in Thermal First-Order Phase
    Transitions.” <i>Physical Review X</i>, vol. 16, no. 3, 031042, American Physical
    Society, 2026, doi:<a href="https://doi.org/10.1103/4zs8-7kf4">10.1103/4zs8-7kf4</a>.
  short: M. Serbyn, A. Avdoshkin, O.K. Diessel, D.A. Huse, Physical Review X 16 (2026).
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: There are no publicly available research data or software
  supporting this manuscript. Requests for further information or data should be sent
  to the authors.
date_created: 2026-08-24T06:57:25Z
date_published: 2026-08-18T00:00:00Z
date_updated: 2026-09-09T07:01:47Z
day: '18'
ddc:
- '530'
department:
- _id: MaSe
doi: 10.1103/4zs8-7kf4
external_id:
  arxiv:
  - '2601.08347'
file:
- access_level: open_access
  checksum: 8bf0d88f17783dc1e6bf4c754534d734
  content_type: application/pdf
  creator: dernst
  date_created: 2026-09-09T07:00:24Z
  date_updated: 2026-09-09T07:00:24Z
  file_id: '22862'
  file_name: 2026_PhysicalReviewX_Serbyn.pdf
  file_size: 2537492
  relation: main_file
  success: 1
file_date_updated: 2026-09-09T07:00:24Z
fulldoi: https://doi.org/10.1103/4zs8-7kf4
has_accepted_license: '1'
intvolume: '        16'
issue: '3'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
publication: Physical Review X
publication_identifier:
  issn:
  - 2160-3308
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
researchdata_availability: upon request
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Eigenstate thermalization in thermal first-order phase transitions
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22753'
abstract:
- lang: eng
  text: Radial glial progenitors (RGPs) produce all excitatory neurons in the developing
    cerebral cortex. Mosaic analysis with double markers (MADM)-based lineage tracing
    in vivo has revealed a quantitative framework of RGP lineage progression1. Here
    we established MADM technology2,3 in mouse embryonic stem cells to probe RGP lineage
    progression in a self-organizing cortical organoid system. We found that RGPs
    exhibit a high level of plasticity in proliferative potential in organoids rather
    than strict temporally stereotyped lineage progression as observed in vivo. RGPs
    in organoids showed increased lineage restriction, diminishing cell-type diversity
    in clones of cortical projection neurons, despite uniform single-cell transcriptional
    signatures of RGPs and a unitary lineage trajectory. Thus, critical non-cell-autonomous
    cues that are absent in self-organizing systems and/or the genuine stem cell niche
    are essential for faithful temporal control of RGP lineage progression and the
    generation of clonal cortical cell-type diversity.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: PreCl
acknowledgement: We thank M. L. de Guevara, S. Jayaram and A. Heger for technical
  assistance with mESC derivation; M. Goudarzi for assistance with organoid imaging;
  M. Leeb and F. Freeman for advice in culturing mESCs and organoids; S. Gobeil and
  L. Sweeney for reagents and advice for organoid clearing; A. Heger for mouse colony
  management; J. Hauser for technical assistance; the Stanford Brain Organogenesis
  Workshop; and all members of the Hippenmeyer laboratory for discussion and/or comments
  on the manuscript. This study was supported by the Scientific Service Units (SSU)
  of the Institute of Science and Technology, Austria through resources provided by
  the Imaging and Optics Facility (IOF), Laboratory Support Facility (LSF) and Preclinical
  Facility (PCF). M.S. received funding from the European Commission (IST plus postdoctoral
  fellowship). This work was supported by ISTA institutional funds to S.H., FWF SFB
  F78 Neuro Stem Modulation to S.H., and by the European Research Council (ERC) under
  the European Union’s Horizon 2020 Research And Innovation Program (grant agreement
  725780 LinPro) to S.H. Open access funding provided by Institute of Science and
  Technology (IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Melissa A
  full_name: Stouffer, Melissa A
  id: 4C9372C4-F248-11E8-B48F-1D18A9856A87
  last_name: Stouffer
- first_name: Osvaldo
  full_name: Miranda, Osvaldo
  id: 862A3C56-A8BF-11E9-B4FA-D9E3E5697425
  last_name: Miranda
  orcid: 0000-0001-6618-6889
- first_name: Florian
  full_name: Pauler, Florian
  id: 48EA0138-F248-11E8-B48F-1D18A9856A87
  last_name: Pauler
  orcid: 0000-0002-7462-0048
- first_name: Fabrizia
  full_name: Pipicelli, Fabrizia
  id: 649134fd-d012-11ed-8f82-db1e5050f9ba
  last_name: Pipicelli
- first_name: Carmen
  full_name: Streicher, Carmen
  id: 36BCB99C-F248-11E8-B48F-1D18A9856A87
  last_name: Streicher
- first_name: Giselle T
  full_name: Cheung, Giselle T
  id: 471195F6-F248-11E8-B48F-1D18A9856A87
  last_name: Cheung
  orcid: 0000-0001-8457-2572
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
citation:
  ama: Stouffer MA, Miranda O, Pauler F, et al. Temporal uncoupling of radial glia
    lineage progression in cortical organoids. <i>Nature</i>. 2026. doi:<a href="https://doi.org/10.1038/s41586-026-10916-7">10.1038/s41586-026-10916-7</a>
  apa: Stouffer, M. A., Miranda, O., Pauler, F., Pipicelli, F., Streicher, C., Cheung,
    G. T., &#38; Hippenmeyer, S. (2026). Temporal uncoupling of radial glia lineage
    progression in cortical organoids. <i>Nature</i>. Springer Nature. <a href="https://doi.org/10.1038/s41586-026-10916-7">https://doi.org/10.1038/s41586-026-10916-7</a>
  chicago: Stouffer, Melissa A, Osvaldo Miranda, Florian Pauler, Fabrizia Pipicelli,
    Carmen Streicher, Giselle T Cheung, and Simon Hippenmeyer. “Temporal Uncoupling
    of Radial Glia Lineage Progression in Cortical Organoids.” <i>Nature</i>. Springer
    Nature, 2026. <a href="https://doi.org/10.1038/s41586-026-10916-7">https://doi.org/10.1038/s41586-026-10916-7</a>.
  ieee: M. A. Stouffer <i>et al.</i>, “Temporal uncoupling of radial glia lineage
    progression in cortical organoids,” <i>Nature</i>. Springer Nature, 2026.
  ista: Stouffer MA, Miranda O, Pauler F, Pipicelli F, Streicher C, Cheung GT, Hippenmeyer
    S. 2026. Temporal uncoupling of radial glia lineage progression in cortical organoids.
    Nature.
  mla: Stouffer, Melissa A., et al. “Temporal Uncoupling of Radial Glia Lineage Progression
    in Cortical Organoids.” <i>Nature</i>, Springer Nature, 2026, doi:<a href="https://doi.org/10.1038/s41586-026-10916-7">10.1038/s41586-026-10916-7</a>.
  short: M.A. Stouffer, O. Miranda, F. Pauler, F. Pipicelli, C. Streicher, G.T. Cheung,
    S. Hippenmeyer, Nature (2026).
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: All data generated and analysed in this study are included
  in the paper, source data and/or Supplementary Tables 2 and 3. Raw sequencing data
  have been deposited with Gene Expression Omnibus (GEO) accession number GSE327470.
  Source data are provided with this paper. All scripts used to prepare data and figures
  for this manuscript are accessible on GitHub at https://github.com/fpauler/Temporal-Uncoupling-of-Radial-Glia-Lineage-Progression-in-Cortical-Organoid.
date_created: 2026-08-23T22:01:47Z
date_published: 2026-08-12T00:00:00Z
date_updated: 2026-09-09T07:11:02Z
day: '12'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1038/s41586-026-10916-7
ec_funded: 1
external_id:
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- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 059F6AB4-7A3F-11EA-A408-12923DDC885E
  grant_number: F7805
  name: Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular
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- _id: 260018B0-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '725780'
  name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: Nature
publication_identifier:
  eissn:
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  issn:
  - 0028-0836
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: yes
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supplementarymaterial: yes
title: Temporal uncoupling of radial glia lineage progression in cortical organoids
tmp:
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type: journal_article
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---
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abstract:
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  text: Elucidating reaction mechanisms requires efficient generation of transition
    states (TSs) and products. Existing diffusion and sequence-based models accelerate
    parts of this process over traditional string-based methods, but typically still
    require manual enumeration of either TSs or products, and stochastic diffusion
    dynamics can be inefficient and hard to control. We introduce MolGEN, a conditional
    flow-matching framework that uses deterministic optimal transport to map Gaussian
    priors to chemical distributions. For TS generation, MolGEN improves TS geometry
    and barrier-height prediction over diffusion models while enabling sub-second
    sampling. For reaction product generation, it achieves competitive top-k accuracy
    while preserving mass and electron balance. Using the same backbone for TS and
    product sampling, MolGEN enables template-free generative exploration of reaction
    networks without the repeated quantum-chemistry searches required by prior methods.
    For the γ-ketohydroperoxide decomposition network, it produces more valid TSs
    than string-based methods using only 12 quantum-chemistry evaluations instead
    of 1156, and identifies a lower-barrier pathway.
acknowledgement: P.T. thanks valued discussions with Dr. Peichen Zhong, Dr. Hao Tang,
  and Dr. Chengbin Zhao. P.T. thanks Dr. Dingshun Lv, Dr. Zechang Sun, and Dr. Chenxi
  Hu for identifying an important bug in an early version of the code package. The
  authors acknowledge the resources of the National Energy Research Scientific Computing
  Center (NERSC), a Department of Energy Office of Science User Facility using NERSC
  award DOEERCAP0031751 ‘GenAI@NERSC’. P.T. acknowledges funding from the BIDMaP Postdoctoral
  Fellowship.
article_number: '8769'
article_processing_charge: Yes
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arxiv: 1
author:
- first_name: Ping
  full_name: Tuo, Ping
  id: 6e5644c0-c180-11ed-a2da-facc4c9f4f09
  last_name: Tuo
- first_name: Jiale
  full_name: Chen, Jiale
  id: 4d0a9064-1ff6-11ee-9fa6-ec046c604785
  last_name: Chen
  orcid: 0000-0001-5337-5875
- first_name: Ju
  full_name: Li, Ju
  last_name: Li
citation:
  ama: Tuo P, Chen J, Li J. Flow matching for reaction pathway generation. <i>Nature
    Communications</i>. 2026;17. doi:<a href="https://doi.org/10.1038/s41467-026-75654-w">10.1038/s41467-026-75654-w</a>
  apa: Tuo, P., Chen, J., &#38; Li, J. (2026). Flow matching for reaction pathway
    generation. <i>Nature Communications</i>. Springer Nature. <a href="https://doi.org/10.1038/s41467-026-75654-w">https://doi.org/10.1038/s41467-026-75654-w</a>
  chicago: Tuo, Ping, Jiale Chen, and Ju Li. “Flow Matching for Reaction Pathway Generation.”
    <i>Nature Communications</i>. Springer Nature, 2026. <a href="https://doi.org/10.1038/s41467-026-75654-w">https://doi.org/10.1038/s41467-026-75654-w</a>.
  ieee: P. Tuo, J. Chen, and J. Li, “Flow matching for reaction pathway generation,”
    <i>Nature Communications</i>, vol. 17. Springer Nature, 2026.
  ista: Tuo P, Chen J, Li J. 2026. Flow matching for reaction pathway generation.
    Nature Communications. 17, 8769.
  mla: Tuo, Ping, et al. “Flow Matching for Reaction Pathway Generation.” <i>Nature
    Communications</i>, vol. 17, 8769, Springer Nature, 2026, doi:<a href="https://doi.org/10.1038/s41467-026-75654-w">10.1038/s41467-026-75654-w</a>.
  short: P. Tuo, J. Chen, J. Li, Nature Communications 17 (2026).
das_tickbox: '1'
dataavailabilitystatement: Structures generated in this study are provided in the
  Source Data file, and deposited in the GitHub repository https://github.com/tuoping/MolGEN
  and the figshare database under accession code https://doi.org/10.6084/m9.figshare.30576365.
  Source data are provided in this paper. The MolGEN codebase is available as an open-source
  repository for continuous development at https://github.com/tuoping/MolGEN. A release
  of the code used in this work has been archived on Zenodo47.
date_created: 2026-08-30T22:01:43Z
date_published: 2026-08-21T00:00:00Z
date_updated: 2026-09-09T07:28:15Z
day: '21'
ddc:
- '000'
department:
- _id: DaAl
- _id: GradSch
doi: 10.1038/s41467-026-75654-w
external_id:
  arxiv:
  - '2507.10530'
  pmid:
  - '42469237'
file:
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  date_created: 2026-09-09T07:25:19Z
  date_updated: 2026-09-09T07:25:19Z
  file_id: '22864'
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intvolume: '        17'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Flow matching for reaction pathway generation
tmp:
  image: /images/cc_by.png
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  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
OA_place: repository
_id: '22852'
abstract:
- lang: eng
  text: "This Research Data contains supplemental videos for Chapter 4 \"Designing
    bistable nanostructures for target behavior\" of my PhD Thesis \"Biological functionality
    without biochemistry: designing nanomachines for target behavior\".\r\nSupplemental
    video 1: Video showing the transition pathway of a bistable nanostructure with
    sphere-based arms, corresponding to the Machine in Scenario 4.\r\nSupplemental
    video 2: Video showing the transition pathway of the Source in Scenario 1. The
    arm tips change sides during the transition, demonstrating that the arms pass
    through each other.\r\nSupplemental video 3: Video showing the transition pathway
    of a fully polyhedral hinge structure with unconstrained arms. Note that we only
    show the ends of the arms.\r\nSupplemental video 4: Video showing the transition
    pathway of the coupled energy-delivery reaction of a Machine (gray) and a Source
    (blue) nanostructure for the optimized parameters in Scenario 3. Note that we
    only show the ends of the arms."
acknowledged_ssus:
- _id: ScienComp
article_processing_charge: No
author:
- first_name: Andreas
  full_name: Ehrmann, Andreas
  id: eaa689ed-f6e0-11ea-865d-bd98cbcf83c2
  last_name: Ehrmann
  orcid: 0000-0002-0997-5678
citation:
  ama: Ehrmann A. Supplemental videos for Designing bistable nanostructures for target
    behavior. 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-22852">10.15479/AT-ISTA-22852</a>
  apa: Ehrmann, A. (2026). Supplemental videos for Designing bistable nanostructures
    for target behavior. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-22852">https://doi.org/10.15479/AT-ISTA-22852</a>
  chicago: Ehrmann, Andreas. “Supplemental Videos for Designing Bistable Nanostructures
    for Target Behavior.” Institute of Science and Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-22852">https://doi.org/10.15479/AT-ISTA-22852</a>.
  ieee: A. Ehrmann, “Supplemental videos for Designing bistable nanostructures for
    target behavior.” Institute of Science and Technology Austria, 2026.
  ista: Ehrmann A. 2026. Supplemental videos for Designing bistable nanostructures
    for target behavior, Institute of Science and Technology Austria, <a href="https://doi.org/10.15479/AT-ISTA-22852">10.15479/AT-ISTA-22852</a>.
  mla: Ehrmann, Andreas. <i>Supplemental Videos for Designing Bistable Nanostructures
    for Target Behavior</i>. Institute of Science and Technology Austria, 2026, doi:<a
    href="https://doi.org/10.15479/AT-ISTA-22852">10.15479/AT-ISTA-22852</a>.
  short: A. Ehrmann, (2026).
contributor:
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  first_name: Andreas
  id: eaa689ed-f6e0-11ea-865d-bd98cbcf83c2
  last_name: Ehrmann
  orcid: 0000-0002-0997-5678
corr_author: '1'
date_created: 2026-09-08T11:32:53Z
date_published: 2026-09-09T00:00:00Z
date_updated: 2026-09-09T07:24:10Z
day: '09'
department:
- _id: GradSch
- _id: CaGo
- _id: EdHa
doi: 10.15479/AT-ISTA-22852
doi_confirm: '1'
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file_date_updated: 2026-09-08T18:36:14Z
fulldoi: https://doi.org/10.15479/AT-ISTA-22852
has_accepted_license: '1'
keyword:
- functional nanostructures
- bistability
- target behavior
- transition pathway
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '09'
oa: 1
oa_version: None
project:
- _id: 90a98bb5-16d5-11f0-9cad-9675f3f8015d
  grant_number: PAT 8537123
  name: Functional bio-inspired nanomachines from sticky colloids
publisher: Institute of Science and Technology Austria
status: public
title: Supplemental videos for Designing bistable nanostructures for target behavior
tmp:
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...
---
OA_type: closed access
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abstract:
- lang: eng
  text: Using transition metals efficiently in aqueous batteries requires transferring
    multiple electrons per metal, which leads to difficult-to-manage conversion reactions.
    It is now shown how vanadium can be changed from one-electron insertion to four-electron
    conversion.
article_processing_charge: No
article_type: comment
author:
- first_name: Stefan Alexander
  full_name: Freunberger, Stefan Alexander
  id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
  last_name: Freunberger
  orcid: 0000-0003-2902-5319
citation:
  ama: Freunberger SA. Triggering conversion in vanadium electrodes. <i>Nature Materials</i>.
    2026;25(9):1482-1483. doi:<a href="https://doi.org/10.1038/s41563-026-02714-3">10.1038/s41563-026-02714-3</a>
  apa: Freunberger, S. A. (2026). Triggering conversion in vanadium electrodes. <i>Nature
    Materials</i>. Springer Nature. <a href="https://doi.org/10.1038/s41563-026-02714-3">https://doi.org/10.1038/s41563-026-02714-3</a>
  chicago: Freunberger, Stefan Alexander. “Triggering Conversion in Vanadium Electrodes.”
    <i>Nature Materials</i>. Springer Nature, 2026. <a href="https://doi.org/10.1038/s41563-026-02714-3">https://doi.org/10.1038/s41563-026-02714-3</a>.
  ieee: S. A. Freunberger, “Triggering conversion in vanadium electrodes,” <i>Nature
    Materials</i>, vol. 25, no. 9. Springer Nature, pp. 1482–1483, 2026.
  ista: Freunberger SA. 2026. Triggering conversion in vanadium electrodes. Nature
    Materials. 25(9), 1482–1483.
  mla: Freunberger, Stefan Alexander. “Triggering Conversion in Vanadium Electrodes.”
    <i>Nature Materials</i>, vol. 25, no. 9, Springer Nature, 2026, pp. 1482–83, doi:<a
    href="https://doi.org/10.1038/s41563-026-02714-3">10.1038/s41563-026-02714-3</a>.
  short: S.A. Freunberger, Nature Materials 25 (2026) 1482–1483.
corr_author: '1'
das_tickbox: '0'
date_created: 2026-08-26T18:48:33Z
date_published: 2026-09-01T00:00:00Z
date_updated: 2026-09-09T07:17:13Z
day: '01'
department:
- _id: StFr
doi: 10.1038/s41563-026-02714-3
external_id:
  pmid:
  - '42649374'
fulldoi: https://doi.org/10.1038/s41563-026-02714-3
intvolume: '        25'
issue: '9'
language:
- iso: eng
month: '09'
oa_version: None
page: 1482-1483
pmid: 1
publication: Nature Materials
publication_identifier:
  eissn:
  - 1476-4660
  issn:
  - 1476-1122
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: not applicable
scopus_import: '1'
status: public
supplementarymaterial: not applicable
title: Triggering conversion in vanadium electrodes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 25
year: '2026'
...
