---
_id: '9999'
abstract:
- lang: eng
text: 'The developmental strategies used by progenitor cells to endure a safe journey
from their induction place towards the site of terminal differentiation are still
poorly understood. Here we uncovered a progenitor cell allocation mechanism that
stems from an incomplete process of epithelial delamination that allows progenitors
to coordinate their movement with adjacent extra-embryonic tissues. Progenitors
of the zebrafish laterality organ originate from the surface epithelial enveloping
layer by an apical constriction process of cell delamination. During this process,
progenitors retain long-term apical contacts that enable the epithelial layer
to pull a subset of progenitors along their way towards the vegetal pole. The
remaining delaminated progenitors follow apically-attached progenitors’ movement
by a co-attraction mechanism, avoiding sequestration by the adjacent endoderm,
ensuring their fate and collective allocation at the differentiation site. Thus,
we reveal that incomplete delamination serves as a cellular platform for coordinated
tissue movements during development. Impact Statement: Incomplete delamination
serves as a cellular platform for coordinated tissue movements during development,
guiding newly formed progenitor cell groups to the differentiation site.'
article_number: e66483
article_processing_charge: Yes
article_type: original
author:
- first_name: Eduardo
full_name: Pulgar, Eduardo
last_name: Pulgar
- first_name: Cornelia
full_name: Schwayer, Cornelia
id: 3436488C-F248-11E8-B48F-1D18A9856A87
last_name: Schwayer
orcid: 0000-0001-5130-2226
- first_name: Néstor
full_name: Guerrero, Néstor
last_name: Guerrero
- first_name: Loreto
full_name: López, Loreto
last_name: López
- first_name: Susana
full_name: Márquez, Susana
last_name: Márquez
- first_name: Steffen
full_name: Härtel, Steffen
last_name: Härtel
- first_name: Rodrigo
full_name: Soto, Rodrigo
last_name: Soto
- first_name: Carl Philipp
full_name: Heisenberg, Carl Philipp
last_name: Heisenberg
- first_name: Miguel L.
full_name: Concha, Miguel L.
last_name: Concha
citation:
ama: Pulgar E, Schwayer C, Guerrero N, et al. Apical contacts stemming from incomplete
delamination guide progenitor cell allocation through a dragging mechanism. eLife.
2021;10. doi:10.7554/eLife.66483
apa: Pulgar, E., Schwayer, C., Guerrero, N., López, L., Márquez, S., Härtel, S.,
… Concha, M. L. (2021). Apical contacts stemming from incomplete delamination
guide progenitor cell allocation through a dragging mechanism. ELife. eLife
Sciences Publications. https://doi.org/10.7554/eLife.66483
chicago: Pulgar, Eduardo, Cornelia Schwayer, Néstor Guerrero, Loreto López, Susana
Márquez, Steffen Härtel, Rodrigo Soto, Carl Philipp Heisenberg, and Miguel L.
Concha. “Apical Contacts Stemming from Incomplete Delamination Guide Progenitor
Cell Allocation through a Dragging Mechanism.” ELife. eLife Sciences Publications,
2021. https://doi.org/10.7554/eLife.66483.
ieee: E. Pulgar et al., “Apical contacts stemming from incomplete delamination
guide progenitor cell allocation through a dragging mechanism,” eLife,
vol. 10. eLife Sciences Publications, 2021.
ista: Pulgar E, Schwayer C, Guerrero N, López L, Márquez S, Härtel S, Soto R, Heisenberg
CP, Concha ML. 2021. Apical contacts stemming from incomplete delamination guide
progenitor cell allocation through a dragging mechanism. eLife. 10, e66483.
mla: Pulgar, Eduardo, et al. “Apical Contacts Stemming from Incomplete Delamination
Guide Progenitor Cell Allocation through a Dragging Mechanism.” ELife,
vol. 10, e66483, eLife Sciences Publications, 2021, doi:10.7554/eLife.66483.
short: E. Pulgar, C. Schwayer, N. Guerrero, L. López, S. Márquez, S. Härtel, R.
Soto, C.P. Heisenberg, M.L. Concha, ELife 10 (2021).
date_created: 2021-09-12T22:01:23Z
date_published: 2021-08-27T00:00:00Z
date_updated: 2025-04-14T07:46:58Z
day: '27'
ddc:
- '570'
department:
- _id: CaHe
doi: 10.7554/eLife.66483
ec_funded: 1
external_id:
isi:
- '000700428500001'
pmid:
- '34448451'
file:
- access_level: open_access
checksum: a3f82b0499cc822ac1eab48a01f3f57e
content_type: application/pdf
creator: dernst
date_created: 2022-05-13T08:03:37Z
date_updated: 2022-05-13T08:03:37Z
file_id: '11371'
file_name: 2021_eLife_Pulgar.pdf
file_size: 9010446
relation: main_file
success: 1
file_date_updated: 2022-05-13T08:03:37Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
keyword:
- cell delamination
- apical constriction
- dragging
- mechanical forces
- collective 18 locomotion
- dorsal forerunner cells
- zebrafish
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 260F1432-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742573'
name: Interaction and feedback between cell mechanics and fate specification in
vertebrate gastrulation
publication: eLife
publication_identifier:
eissn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Apical contacts stemming from incomplete delamination guide progenitor cell
allocation through a dragging mechanism
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2021'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21805'
abstract:
- lang: eng
text: Donor–acceptor Stenhouse adducts (DASAs) are visible‐light‐responsive photoswitches
with a variety of emerging applications in photoresponsive materials. Their two‐step
modular synthesis, centered on the nucleophilic ring opening of an activated furan,
makes DASAs readily accessible. However, the use of less reactive donors or acceptors
renders the process slow and low yielding, which has limited their development.
We demonstrate here that 1,1,1,3,3,3‐hexafluoro‐2‐propanol (HFIP) promotes the
ring‐opening reaction and stabilizes the open isomer, allowing greatly reduced
reaction times and increased yields for known derivatives. In addition, it provides
access to previously unattainable DASA‐based photoswitches and DASA–polymer conjugates.
The role of HFIP and the photochromic properties of a set of new DASAs is probed
using a combination of 1H NMR and UV/Vis spectroscopy. The
use of sterically hindered, electron‐poor amines enabled the dark equilibrium
to be decoupled from closed‐isomer half‐lives for the first time.
article_processing_charge: No
article_type: original
author:
- first_name: Michèle
full_name: Clerc, Michèle
last_name: Clerc
- first_name: Friedrich J
full_name: Stricker, Friedrich J
id: 7aca2cfc-46cf-11f0-abd3-8c96b5186745
last_name: Stricker
- first_name: Sebastian
full_name: Ulrich, Sebastian
last_name: Ulrich
- first_name: Miranda
full_name: Sroda, Miranda
last_name: Sroda
- first_name: Nico
full_name: Bruns, Nico
last_name: Bruns
- first_name: Luciano F.
full_name: Boesel, Luciano F.
last_name: Boesel
- first_name: Javier
full_name: Read de Alaniz, Javier
last_name: Read de Alaniz
citation:
ama: Clerc M, Stricker FJ, Ulrich S, et al. Promoting the furan ring‐opening reaction
to access new donor-acceptor Stenhouse adducts with hexafluoroisopropanol. Angewandte
Chemie International Edition. 2021;60(18):10219-10227. doi:10.1002/anie.202100115
apa: Clerc, M., Stricker, F. J., Ulrich, S., Sroda, M., Bruns, N., Boesel, L. F.,
& Read de Alaniz, J. (2021). Promoting the furan ring‐opening reaction to
access new donor-acceptor Stenhouse adducts with hexafluoroisopropanol. Angewandte
Chemie International Edition. Wiley. https://doi.org/10.1002/anie.202100115
chicago: Clerc, Michèle, Friedrich J Stricker, Sebastian Ulrich, Miranda Sroda,
Nico Bruns, Luciano F. Boesel, and Javier Read de Alaniz. “Promoting the Furan
Ring‐opening Reaction to Access New Donor-Acceptor Stenhouse Adducts with Hexafluoroisopropanol.”
Angewandte Chemie International Edition. Wiley, 2021. https://doi.org/10.1002/anie.202100115.
ieee: M. Clerc et al., “Promoting the furan ring‐opening reaction to access
new donor-acceptor Stenhouse adducts with hexafluoroisopropanol,” Angewandte
Chemie International Edition, vol. 60, no. 18. Wiley, pp. 10219–10227, 2021.
ista: Clerc M, Stricker FJ, Ulrich S, Sroda M, Bruns N, Boesel LF, Read de Alaniz
J. 2021. Promoting the furan ring‐opening reaction to access new donor-acceptor
Stenhouse adducts with hexafluoroisopropanol. Angewandte Chemie International
Edition. 60(18), 10219–10227.
mla: Clerc, Michèle, et al. “Promoting the Furan Ring‐opening Reaction to Access
New Donor-Acceptor Stenhouse Adducts with Hexafluoroisopropanol.” Angewandte
Chemie International Edition, vol. 60, no. 18, Wiley, 2021, pp. 10219–27,
doi:10.1002/anie.202100115.
short: M. Clerc, F.J. Stricker, S. Ulrich, M. Sroda, N. Bruns, L.F. Boesel, J. Read
de Alaniz, Angewandte Chemie International Edition 60 (2021) 10219–10227.
date_created: 2026-05-06T10:42:50Z
date_published: 2021-04-26T00:00:00Z
date_updated: 2026-05-11T07:40:12Z
day: '26'
ddc:
- '540'
doi: 10.1002/anie.202100115
extern: '1'
external_id:
pmid:
- '33503292'
intvolume: ' 60'
issue: '18'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1002/anie.202100115
month: '04'
oa: 1
oa_version: Published Version
page: 10219-10227
pmid: 1
publication: Angewandte Chemie International Edition
publication_identifier:
issn:
- 1521-3773
issnl:
- 1433-7851
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Promoting the furan ring‐opening reaction to access new donor-acceptor Stenhouse
adducts with hexafluoroisopropanol
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 60
year: '2021'
...
---
OA_type: closed access
_id: '21808'
abstract:
- lang: eng
text: A convenient approach for the synthesis of foldable redox-active flavin peptide
conjugates was established. A model β-hairpin oligopeptide motif was utilized
to demonstrate that azidolysine side-chains are readily functionalised with an
alkyne-bearing flavine derivative. The folding equilibrium of the peptide backbone
as well as the redox behaviour of the flavin moieties remains intact after the
conjugation.
article_processing_charge: No
article_type: original
author:
- first_name: Friedrich J
full_name: Stricker, Friedrich J
id: 7aca2cfc-46cf-11f0-abd3-8c96b5186745
last_name: Stricker
- first_name: Jonas Christopher
full_name: Kölsch, Jonas Christopher
last_name: Kölsch
- first_name: Sebastian B.
full_name: Beil, Sebastian B.
last_name: Beil
- first_name: Sebastian
full_name: Preiß, Sebastian
last_name: Preiß
- first_name: Siegfried R.
full_name: Waldvogel, Siegfried R.
last_name: Waldvogel
- first_name: Till
full_name: Opatz, Till
last_name: Opatz
- first_name: Pol
full_name: Besenius, Pol
last_name: Besenius
citation:
ama: Stricker FJ, Kölsch JC, Beil SB, et al. Facile access to foldable redox-active
flavin-peptide conjugates. Organic & Biomolecular Chemistry. 2021;19(20):4483-4486.
doi:10.1039/d1ob00414j
apa: Stricker, F. J., Kölsch, J. C., Beil, S. B., Preiß, S., Waldvogel, S. R., Opatz,
T., & Besenius, P. (2021). Facile access to foldable redox-active flavin-peptide
conjugates. Organic & Biomolecular Chemistry. Royal Society of Chemistry.
https://doi.org/10.1039/d1ob00414j
chicago: Stricker, Friedrich J, Jonas Christopher Kölsch, Sebastian B. Beil, Sebastian
Preiß, Siegfried R. Waldvogel, Till Opatz, and Pol Besenius. “Facile Access to
Foldable Redox-Active Flavin-Peptide Conjugates.” Organic & Biomolecular
Chemistry. Royal Society of Chemistry, 2021. https://doi.org/10.1039/d1ob00414j.
ieee: F. J. Stricker et al., “Facile access to foldable redox-active flavin-peptide
conjugates,” Organic & Biomolecular Chemistry, vol. 19, no. 20. Royal
Society of Chemistry, pp. 4483–4486, 2021.
ista: Stricker FJ, Kölsch JC, Beil SB, Preiß S, Waldvogel SR, Opatz T, Besenius
P. 2021. Facile access to foldable redox-active flavin-peptide conjugates. Organic
& Biomolecular Chemistry. 19(20), 4483–4486.
mla: Stricker, Friedrich J., et al. “Facile Access to Foldable Redox-Active Flavin-Peptide
Conjugates.” Organic & Biomolecular Chemistry, vol. 19, no. 20, Royal
Society of Chemistry, 2021, pp. 4483–86, doi:10.1039/d1ob00414j.
short: F.J. Stricker, J.C. Kölsch, S.B. Beil, S. Preiß, S.R. Waldvogel, T. Opatz,
P. Besenius, Organic & Biomolecular Chemistry 19 (2021) 4483–4486.
date_created: 2026-05-06T10:44:41Z
date_published: 2021-04-27T00:00:00Z
date_updated: 2026-05-11T07:34:17Z
day: '27'
ddc:
- '540'
doi: 10.1039/d1ob00414j
extern: '1'
external_id:
pmid:
- '33960997'
intvolume: ' 19'
issue: '20'
language:
- iso: eng
month: '04'
oa_version: None
page: 4483-4486
pmid: 1
publication: Organic & Biomolecular Chemistry
publication_identifier:
eissn:
- 1477-0539
issn:
- 1477-0520
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: Facile access to foldable redox-active flavin-peptide conjugates
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2021'
...
---
OA_type: closed access
_id: '21811'
abstract:
- lang: eng
text: The effects of solution‐state dielectric and intermolecular interactions on
the degree of charge separation provide a route to understanding the switching
properties and concentration dependence of donor–acceptor Stenhouse adducts (DASAs).
Through solvatochromic analysis of the open‐form DASA in conjunction with X‐ray
diffraction and computational theory, we have analyzed the ionic character of
a series of DASAs. First‐ and third‐generation architectures lead to a higher
zwitterionic resonance contribution of the open form and a zwitterionic closed
form, whereas the second‐generation architecture possesses a less charge‐separated
open form and neutral closed form. This can be correlated with equilibrium control
and photoswitching solvent compatibility. As a result of the high contribution
of the zwitterionic resonance forms of first‐ and third‐generation DASAs, we were
able to control their switching kinetics by means of ion concentration, whereas
second‐generation DASAs were less affected. Importantly, these results show how
the previously reported concentration dependence of DASAs is not universal, and
that DASAs with a more hybrid structure in the open form can achieve photoswitching
at high concentrations.
article_processing_charge: No
article_type: original
author:
- first_name: Miranda M.
full_name: Sroda, Miranda M.
last_name: Sroda
- first_name: Friedrich J
full_name: Stricker, Friedrich J
id: 7aca2cfc-46cf-11f0-abd3-8c96b5186745
last_name: Stricker
- first_name: Julie A.
full_name: Peterson, Julie A.
last_name: Peterson
- first_name: Alexandria
full_name: Bernal, Alexandria
last_name: Bernal
- first_name: Javier
full_name: Read de Alaniz, Javier
last_name: Read de Alaniz
citation:
ama: 'Sroda MM, Stricker FJ, Peterson JA, Bernal A, Read de Alaniz J. Donor–acceptor
Stenhouse adducts: Exploring the effects of ionic character. Chemistry - A
European Journal. 2021;27(12):4183-4190. doi:10.1002/chem.202005110'
apa: 'Sroda, M. M., Stricker, F. J., Peterson, J. A., Bernal, A., & Read de
Alaniz, J. (2021). Donor–acceptor Stenhouse adducts: Exploring the effects of
ionic character. Chemistry - A European Journal. Wiley. https://doi.org/10.1002/chem.202005110'
chicago: 'Sroda, Miranda M., Friedrich J Stricker, Julie A. Peterson, Alexandria
Bernal, and Javier Read de Alaniz. “Donor–Acceptor Stenhouse Adducts: Exploring
the Effects of Ionic Character.” Chemistry - A European Journal. Wiley,
2021. https://doi.org/10.1002/chem.202005110.'
ieee: 'M. M. Sroda, F. J. Stricker, J. A. Peterson, A. Bernal, and J. Read de Alaniz,
“Donor–acceptor Stenhouse adducts: Exploring the effects of ionic character,”
Chemistry - A European Journal, vol. 27, no. 12. Wiley, pp. 4183–4190,
2021.'
ista: 'Sroda MM, Stricker FJ, Peterson JA, Bernal A, Read de Alaniz J. 2021. Donor–acceptor
Stenhouse adducts: Exploring the effects of ionic character. Chemistry - A European
Journal. 27(12), 4183–4190.'
mla: 'Sroda, Miranda M., et al. “Donor–Acceptor Stenhouse Adducts: Exploring the
Effects of Ionic Character.” Chemistry - A European Journal, vol. 27, no.
12, Wiley, 2021, pp. 4183–90, doi:10.1002/chem.202005110.'
short: M.M. Sroda, F.J. Stricker, J.A. Peterson, A. Bernal, J. Read de Alaniz, Chemistry
- A European Journal 27 (2021) 4183–4190.
date_created: 2026-05-06T10:50:27Z
date_published: 2021-02-24T00:00:00Z
date_updated: 2026-05-12T06:48:12Z
day: '24'
ddc:
- '540'
doi: 10.1002/chem.202005110
extern: '1'
external_id:
pmid:
- '33348446'
intvolume: ' 27'
issue: '12'
language:
- iso: eng
month: '02'
oa_version: None
page: 4183-4190
pmid: 1
publication: Chemistry - A European Journal
publication_identifier:
eissn:
- 1521-3765
issn:
- 0947-6539
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Donor–acceptor Stenhouse adducts: Exploring the effects of ionic character'
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 27
year: '2021'
...
---
OA_type: closed access
_id: '21816'
abstract:
- lang: eng
text: 'A new Diels−Alder (DA)-based photopatterning platform is presented, which
exploits the irreversible, light-induced decarbonylation and subsequent cleavage
of cyclopentadienone−norbornadiene (CPD−NBD) adducts. A series of CPD−NBD adducts
have been prepared and systematically studied toward the use in a polymeric material
photopatterning platform. By incorporating an optimized CPD−NBD adduct into polymer
networks, it is demonstrated that cyclopentadiene may be unveiled upon 365 nm
irradiation and subsequently clicked to a variety of maleimides with spatial control
under mild reaction conditions and with fast kinetics. Unlike currently available
photoinduced Diels−Alder reactions that rely on trapping transient, photocaged
dienes, this platform introduces a persistent, yet highly reactive diene after
irradiation, enabling the use of photosensitive species such as cyanine dyes to
be patterned. To highlight the potential use of this platform in a variety of
material applications, we demonstrate two proof-of-concepts: patterned conjugation
of multiple dyes into apolyacrylate network and preprogrammed ligation of streptavidin
into poly(ethylene glycol) hydrogels.'
article_processing_charge: No
article_type: original
author:
- first_name: Sophia J.
full_name: Bailey, Sophia J.
last_name: Bailey
- first_name: Friedrich J
full_name: Stricker, Friedrich J
id: 7aca2cfc-46cf-11f0-abd3-8c96b5186745
last_name: Stricker
- first_name: Erik
full_name: Hopkins, Erik
last_name: Hopkins
- first_name: Maxwell Z.
full_name: Wilson, Maxwell Z.
last_name: Wilson
- first_name: Javier
full_name: Read de Alaniz, Javier
last_name: Read de Alaniz
citation:
ama: Bailey SJ, Stricker FJ, Hopkins E, Wilson MZ, Read de Alaniz J. Shining light
on cyclopentadienone–norbornadiene Diels-Alder adducts to enable photoinduced
click chemistry with cyclopentadiene. ACS Applied Materials & Interfaces.
2021;13(30):35422-35430. doi:10.1021/acsami.1c08670
apa: Bailey, S. J., Stricker, F. J., Hopkins, E., Wilson, M. Z., & Read de Alaniz,
J. (2021). Shining light on cyclopentadienone–norbornadiene Diels-Alder adducts
to enable photoinduced click chemistry with cyclopentadiene. ACS Applied Materials
& Interfaces. American Chemical Society. https://doi.org/10.1021/acsami.1c08670
chicago: Bailey, Sophia J., Friedrich J Stricker, Erik Hopkins, Maxwell Z. Wilson,
and Javier Read de Alaniz. “Shining Light on Cyclopentadienone–Norbornadiene Diels-Alder
Adducts to Enable Photoinduced Click Chemistry with Cyclopentadiene.” ACS Applied
Materials & Interfaces. American Chemical Society, 2021. https://doi.org/10.1021/acsami.1c08670.
ieee: S. J. Bailey, F. J. Stricker, E. Hopkins, M. Z. Wilson, and J. Read de Alaniz,
“Shining light on cyclopentadienone–norbornadiene Diels-Alder adducts to enable
photoinduced click chemistry with cyclopentadiene,” ACS Applied Materials &
Interfaces, vol. 13, no. 30. American Chemical Society, pp. 35422–35430, 2021.
ista: Bailey SJ, Stricker FJ, Hopkins E, Wilson MZ, Read de Alaniz J. 2021. Shining
light on cyclopentadienone–norbornadiene Diels-Alder adducts to enable photoinduced
click chemistry with cyclopentadiene. ACS Applied Materials & Interfaces.
13(30), 35422–35430.
mla: Bailey, Sophia J., et al. “Shining Light on Cyclopentadienone–Norbornadiene
Diels-Alder Adducts to Enable Photoinduced Click Chemistry with Cyclopentadiene.”
ACS Applied Materials & Interfaces, vol. 13, no. 30, American Chemical
Society, 2021, pp. 35422–30, doi:10.1021/acsami.1c08670.
short: S.J. Bailey, F.J. Stricker, E. Hopkins, M.Z. Wilson, J. Read de Alaniz, ACS
Applied Materials & Interfaces 13 (2021) 35422–35430.
date_created: 2026-05-06T10:54:16Z
date_published: 2021-07-26T00:00:00Z
date_updated: 2026-05-12T09:49:57Z
day: '26'
ddc:
- '540'
doi: 10.1021/acsami.1c08670
extern: '1'
external_id:
pmid:
- '34310127'
intvolume: ' 13'
issue: '30'
keyword:
- click chemistry
- Diels−Alder
- cyclopentadiene
- photochemistry
- photopatterning
language:
- iso: eng
month: '07'
oa_version: None
page: 35422-35430
pmid: 1
publication: ACS Applied Materials & Interfaces
publication_identifier:
eissn:
- 1944-8252
issn:
- 1944-8244
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Shining light on cyclopentadienone–norbornadiene Diels-Alder adducts to enable
photoinduced click chemistry with cyclopentadiene
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 13
year: '2021'
...
---
OA_type: closed access
_id: '21820'
abstract:
- lang: eng
text: Photosurfactants have shown considerable promise for enabling stimuli-responsive
control of the properties and motion of fluid interfaces. Recently, a number of
photoswitch chemistries have emerged to tailor the photoresponsive properties
of photosurfactants. However, systematic studies investigating how photoresponsive
surfactant behavior depends on the photochemical and photophysical properties
of the switch remain scarce. In this work, we develop synthetic schemes and surfactant
designs to produce a well-controlled library of photosurfactants to comparatively
assess the behavior of photoswitch chemistry on interfacial behavior. We employ
photoinduced spreading of droplets at fluid interfaces as a model for such studies.
We show that although photosurfactant response is largely guided by expected trends
with changes in polarity of the photoswitch, interfacial behavior also depends
nontrivially and sometimes counter-intuitively on the kinetics and mechanisms
of photoswitching, particularly at the interface of two solvents, as well as on
complex interactions with other surfactants. Understanding these complexities
enables the design of new photosurfactant systems and their optimization toward
responsive functions including triggered spreading, dewetting, and destabilization
of droplets on solid and fluid surfaces.
article_processing_charge: No
article_type: original
author:
- first_name: Serena
full_name: Seshadri, Serena
last_name: Seshadri
- first_name: Sophia J.
full_name: Bailey, Sophia J.
last_name: Bailey
- first_name: Lei
full_name: Zhao, Lei
last_name: Zhao
- first_name: Julia
full_name: Fisher, Julia
last_name: Fisher
- first_name: Miranda
full_name: Sroda, Miranda
last_name: Sroda
- first_name: Michelle
full_name: Chiu, Michelle
last_name: Chiu
- first_name: Friedrich J
full_name: Stricker, Friedrich J
id: 7aca2cfc-46cf-11f0-abd3-8c96b5186745
last_name: Stricker
- first_name: Megan T.
full_name: Valentine, Megan T.
last_name: Valentine
- first_name: Javier
full_name: Read de Alaniz, Javier
last_name: Read de Alaniz
- first_name: Matthew E.
full_name: Helgeson, Matthew E.
last_name: Helgeson
citation:
ama: Seshadri S, Bailey SJ, Zhao L, et al. Influence of polarity change and photophysical
effects on photosurfactant-driven wetting. Langmuir. 2021;37(33):9939-9951.
doi:10.1021/acs.langmuir.1c00769
apa: Seshadri, S., Bailey, S. J., Zhao, L., Fisher, J., Sroda, M., Chiu, M., … Helgeson,
M. E. (2021). Influence of polarity change and photophysical effects on photosurfactant-driven
wetting. Langmuir. American Chemical Society. https://doi.org/10.1021/acs.langmuir.1c00769
chicago: Seshadri, Serena, Sophia J. Bailey, Lei Zhao, Julia Fisher, Miranda Sroda,
Michelle Chiu, Friedrich J Stricker, Megan T. Valentine, Javier Read de Alaniz,
and Matthew E. Helgeson. “Influence of Polarity Change and Photophysical Effects
on Photosurfactant-Driven Wetting.” Langmuir. American Chemical Society,
2021. https://doi.org/10.1021/acs.langmuir.1c00769.
ieee: S. Seshadri et al., “Influence of polarity change and photophysical
effects on photosurfactant-driven wetting,” Langmuir, vol. 37, no. 33.
American Chemical Society, pp. 9939–9951, 2021.
ista: Seshadri S, Bailey SJ, Zhao L, Fisher J, Sroda M, Chiu M, Stricker FJ, Valentine
MT, Read de Alaniz J, Helgeson ME. 2021. Influence of polarity change and photophysical
effects on photosurfactant-driven wetting. Langmuir. 37(33), 9939–9951.
mla: Seshadri, Serena, et al. “Influence of Polarity Change and Photophysical Effects
on Photosurfactant-Driven Wetting.” Langmuir, vol. 37, no. 33, American
Chemical Society, 2021, pp. 9939–51, doi:10.1021/acs.langmuir.1c00769.
short: S. Seshadri, S.J. Bailey, L. Zhao, J. Fisher, M. Sroda, M. Chiu, F.J. Stricker,
M.T. Valentine, J. Read de Alaniz, M.E. Helgeson, Langmuir 37 (2021) 9939–9951.
date_created: 2026-05-06T10:56:52Z
date_published: 2021-08-09T00:00:00Z
date_updated: 2026-05-11T07:52:30Z
day: '09'
ddc:
- '540'
doi: 10.1021/acs.langmuir.1c00769
extern: '1'
external_id:
pmid:
- '34370465'
intvolume: ' 37'
issue: '33'
language:
- iso: eng
month: '08'
oa_version: None
page: 9939-9951
pmid: 1
publication: Langmuir
publication_identifier:
eissn:
- 1520-5827
issn:
- 0743-7463
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Influence of polarity change and photophysical effects on photosurfactant-driven
wetting
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 37
year: '2021'
...
---
_id: '10834'
abstract:
- lang: eng
text: Hematopoietic-specific protein 1 (Hem1) is an essential subunit of the WAVE
regulatory complex (WRC) in immune cells. WRC is crucial for Arp2/3 complex activation
and the protrusion of branched actin filament networks. Moreover, Hem1 loss of
function in immune cells causes autoimmune diseases in humans. Here, we show that
genetic removal of Hem1 in macrophages diminishes frequency and efficacy of phagocytosis
as well as phagocytic cup formation in addition to defects in lamellipodial protrusion
and migration. Moreover, Hem1-null macrophages displayed strong defects in cell
adhesion despite unaltered podosome formation and concomitant extracellular matrix
degradation. Specifically, dynamics of both adhesion and de-adhesion as well as
concomitant phosphorylation of paxillin and focal adhesion kinase (FAK) were significantly
compromised. Accordingly, disruption of WRC function in non-hematopoietic cells
coincided with both defects in adhesion turnover and altered FAK and paxillin
phosphorylation. Consistently, platelets exhibited reduced adhesion and diminished
integrin αIIbβ3 activation upon WRC removal. Interestingly, adhesion phenotypes,
but not lamellipodia formation, were partially rescued by small molecule activation
of FAK. A full rescue of the phenotype, including lamellipodia formation, required
not only the presence of WRCs but also their binding to and activation by Rac.
Collectively, our results uncover that WRC impacts on integrin-dependent processes
in a FAK-dependent manner, controlling formation and dismantling of adhesions,
relevant for properly grabbing onto extracellular surfaces and particles during
cell edge expansion, like in migration or phagocytosis.
acknowledgement: We are grateful to Silvia Prettin, Ina Schleicher, and Petra Hagendorff
for expert technical assistance; David Dettbarn for animal keeping and breeding;
and Lothar Gröbe and Maria Höxter for cell sorting. We also thank Werner Tegge for
peptides and Giorgio Scita for antibodies. This work was supported, in part, by
the Deutsche Forschungsgemeinschaft (DFG), Priority Programm SPP1150 (to T.E.B.S.,
K.R., and M. Sixt), and by DFG grant GRK2223/1 (to K.R.). T.E.B.S. acknowledges
support by the Helmholtz Society through HGF impulse fund W2/W3-066 and M. Schnoor
by the Mexican Council for Science and Technology (CONACyT, 284292 ), Fund SEP-Cinvestav
( 108 ), and the Royal Society, UK (Newton Advanced Fellowship, NAF/R1/180017 ).
article_processing_charge: No
article_type: original
author:
- first_name: Stephanie
full_name: Stahnke, Stephanie
last_name: Stahnke
- first_name: Hermann
full_name: Döring, Hermann
last_name: Döring
- first_name: Charly
full_name: Kusch, Charly
last_name: Kusch
- first_name: David J.J.
full_name: de Gorter, David J.J.
last_name: de Gorter
- first_name: Sebastian
full_name: Dütting, Sebastian
last_name: Dütting
- first_name: Aleks
full_name: Guledani, Aleks
last_name: Guledani
- first_name: Irina
full_name: Pleines, Irina
last_name: Pleines
- first_name: Michael
full_name: Schnoor, Michael
last_name: Schnoor
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Robert
full_name: Geffers, Robert
last_name: Geffers
- first_name: Manfred
full_name: Rohde, Manfred
last_name: Rohde
- first_name: Mathias
full_name: Müsken, Mathias
last_name: Müsken
- first_name: Frieda
full_name: Kage, Frieda
last_name: Kage
- first_name: Anika
full_name: Steffen, Anika
last_name: Steffen
- first_name: Jan
full_name: Faix, Jan
last_name: Faix
- first_name: Bernhard
full_name: Nieswandt, Bernhard
last_name: Nieswandt
- first_name: Klemens
full_name: Rottner, Klemens
last_name: Rottner
- first_name: Theresia E.B.
full_name: Stradal, Theresia E.B.
last_name: Stradal
citation:
ama: Stahnke S, Döring H, Kusch C, et al. Loss of Hem1 disrupts macrophage function
and impacts migration, phagocytosis, and integrin-mediated adhesion. Current
Biology. 2021;31(10):2051-2064.e8. doi:10.1016/j.cub.2021.02.043
apa: Stahnke, S., Döring, H., Kusch, C., de Gorter, D. J. J., Dütting, S., Guledani,
A., … Stradal, T. E. B. (2021). Loss of Hem1 disrupts macrophage function and
impacts migration, phagocytosis, and integrin-mediated adhesion. Current Biology.
Elsevier. https://doi.org/10.1016/j.cub.2021.02.043
chicago: Stahnke, Stephanie, Hermann Döring, Charly Kusch, David J.J. de Gorter,
Sebastian Dütting, Aleks Guledani, Irina Pleines, et al. “Loss of Hem1 Disrupts
Macrophage Function and Impacts Migration, Phagocytosis, and Integrin-Mediated
Adhesion.” Current Biology. Elsevier, 2021. https://doi.org/10.1016/j.cub.2021.02.043.
ieee: S. Stahnke et al., “Loss of Hem1 disrupts macrophage function and impacts
migration, phagocytosis, and integrin-mediated adhesion,” Current Biology,
vol. 31, no. 10. Elsevier, p. 2051–2064.e8, 2021.
ista: Stahnke S, Döring H, Kusch C, de Gorter DJJ, Dütting S, Guledani A, Pleines
I, Schnoor M, Sixt MK, Geffers R, Rohde M, Müsken M, Kage F, Steffen A, Faix J,
Nieswandt B, Rottner K, Stradal TEB. 2021. Loss of Hem1 disrupts macrophage function
and impacts migration, phagocytosis, and integrin-mediated adhesion. Current Biology.
31(10), 2051–2064.e8.
mla: Stahnke, Stephanie, et al. “Loss of Hem1 Disrupts Macrophage Function and Impacts
Migration, Phagocytosis, and Integrin-Mediated Adhesion.” Current Biology,
vol. 31, no. 10, Elsevier, 2021, p. 2051–2064.e8, doi:10.1016/j.cub.2021.02.043.
short: S. Stahnke, H. Döring, C. Kusch, D.J.J. de Gorter, S. Dütting, A. Guledani,
I. Pleines, M. Schnoor, M.K. Sixt, R. Geffers, M. Rohde, M. Müsken, F. Kage, A.
Steffen, J. Faix, B. Nieswandt, K. Rottner, T.E.B. Stradal, Current Biology 31
(2021) 2051–2064.e8.
date_created: 2022-03-08T07:51:04Z
date_published: 2021-05-24T00:00:00Z
date_updated: 2023-08-17T07:01:14Z
day: '24'
department:
- _id: MiSi
doi: 10.1016/j.cub.2021.02.043
external_id:
isi:
- '000654652200002'
pmid:
- '33711252'
intvolume: ' 31'
isi: 1
issue: '10'
keyword:
- General Agricultural and Biological Sciences
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2020.03.24.005835
month: '05'
oa: 1
oa_version: Preprint
page: 2051-2064.e8
pmid: 1
publication: Current Biology
publication_identifier:
issn:
- 0960-9822
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Loss of Hem1 disrupts macrophage function and impacts migration, phagocytosis,
and integrin-mediated adhesion
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 31
year: '2021'
...
---
_id: '10836'
acknowledgement: This work was supported by the Austrian Science Fund (FWF) grants MCCA W1248-B30 and SFB F4606-B28 to EJJ. CP received a short-term
research fellowship of the European Federation of Immunological Societies (EFIS-IL) for a research visit at Biocruces Bizkaia Health Research Institute, Barakaldo, Spain. VKK received an EFIS-IL short-term research fellowship for a research visit at King’s College London. The
research was funded by the National Institute for Health Research (NIHR) Biomedical
Research Centre (BRC) based at Guy's and St Thomas' NHS Foundation Trust and King's
College London (IS-BRC-1215-20006) (SNK). The authors acknowledge support by the Medical Research Council
(MR/L023091/1) (SNK); Breast Cancer Now (147; KCL-BCN-Q3)(SNK); Cancer Research
UK (C30122/A11527; C30122/A15774) (SNK); Cancer Research UK King's Health Partners Centre at King's College London (C604/A25135) (SNK); CRUK/NIHR in England/DoH for Scotland, Wales and Northern Ireland Experimental Cancer Medicine Centre (C10355/A15587) (SNK). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. Additionally, this work was funded by Instituto de Salud Carlos III through the project "PI16/01223" (Co-funded by European
Regional Development Fund; “A way to make Europe”) to FB and by the Department of Health, Basque Government through the project
“2019111031” to OZ. OZ is recipient of a Sara Borrell 2017 post-doctoral contract
“CD17/00128” funded by Instituto de Salud Carlos III (Co-funded by European Social
Fund; “Investing in your future”).
article_processing_charge: No
article_type: letter_note
author:
- first_name: Christina L.
full_name: Pranger, Christina L.
last_name: Pranger
- first_name: Judit
full_name: Fazekas-Singer, Judit
id: 36432834-F248-11E8-B48F-1D18A9856A87
last_name: Fazekas-Singer
orcid: 0000-0002-8777-3502
- first_name: Verena K.
full_name: Köhler, Verena K.
last_name: Köhler
- first_name: Isabella
full_name: Pali‐Schöll, Isabella
last_name: Pali‐Schöll
- first_name: Alessandro
full_name: Fiocchi, Alessandro
last_name: Fiocchi
- first_name: Sophia N.
full_name: Karagiannis, Sophia N.
last_name: Karagiannis
- first_name: Olatz
full_name: Zenarruzabeitia, Olatz
last_name: Zenarruzabeitia
- first_name: Francisco
full_name: Borrego, Francisco
last_name: Borrego
- first_name: Erika
full_name: Jensen‐Jarolim, Erika
last_name: Jensen‐Jarolim
citation:
ama: 'Pranger CL, Singer J, Köhler VK, et al. PIPE‐cloned human IgE and IgG4 antibodies:
New tools for investigating cow’s milk allergy and tolerance. Allergy.
2021;76(5):1553-1556. doi:10.1111/all.14604'
apa: 'Pranger, C. L., Singer, J., Köhler, V. K., Pali‐Schöll, I., Fiocchi, A., Karagiannis,
S. N., … Jensen‐Jarolim, E. (2021). PIPE‐cloned human IgE and IgG4 antibodies:
New tools for investigating cow’s milk allergy and tolerance. Allergy.
Wiley. https://doi.org/10.1111/all.14604'
chicago: 'Pranger, Christina L., Judit Singer, Verena K. Köhler, Isabella Pali‐Schöll,
Alessandro Fiocchi, Sophia N. Karagiannis, Olatz Zenarruzabeitia, Francisco Borrego,
and Erika Jensen‐Jarolim. “PIPE‐cloned Human IgE and IgG4 Antibodies: New Tools
for Investigating Cow’s Milk Allergy and Tolerance.” Allergy. Wiley, 2021.
https://doi.org/10.1111/all.14604.'
ieee: 'C. L. Pranger et al., “PIPE‐cloned human IgE and IgG4 antibodies:
New tools for investigating cow’s milk allergy and tolerance,” Allergy,
vol. 76, no. 5. Wiley, pp. 1553–1556, 2021.'
ista: 'Pranger CL, Singer J, Köhler VK, Pali‐Schöll I, Fiocchi A, Karagiannis SN,
Zenarruzabeitia O, Borrego F, Jensen‐Jarolim E. 2021. PIPE‐cloned human IgE and
IgG4 antibodies: New tools for investigating cow’s milk allergy and tolerance.
Allergy. 76(5), 1553–1556.'
mla: 'Pranger, Christina L., et al. “PIPE‐cloned Human IgE and IgG4 Antibodies:
New Tools for Investigating Cow’s Milk Allergy and Tolerance.” Allergy,
vol. 76, no. 5, Wiley, 2021, pp. 1553–56, doi:10.1111/all.14604.'
short: C.L. Pranger, J. Singer, V.K. Köhler, I. Pali‐Schöll, A. Fiocchi, S.N. Karagiannis,
O. Zenarruzabeitia, F. Borrego, E. Jensen‐Jarolim, Allergy 76 (2021) 1553–1556.
date_created: 2022-03-08T11:19:05Z
date_published: 2021-05-01T00:00:00Z
date_updated: 2023-09-05T15:58:53Z
day: '01'
ddc:
- '570'
department:
- _id: Bio
doi: 10.1111/all.14604
external_id:
isi:
- '000577708800001'
pmid:
- '32990982'
file:
- access_level: open_access
checksum: 9526f9554112fc027c9f7fa540c488cd
content_type: application/pdf
creator: dernst
date_created: 2022-03-08T11:23:16Z
date_updated: 2022-03-08T11:23:16Z
file_id: '10837'
file_name: 2021_Allergy_Pranger.pdf
file_size: 626081
relation: main_file
success: 1
file_date_updated: 2022-03-08T11:23:16Z
has_accepted_license: '1'
intvolume: ' 76'
isi: 1
issue: '5'
keyword:
- Immunology
- Immunology and Allergy
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 1553-1556
pmid: 1
publication: Allergy
publication_identifier:
eissn:
- 1398-9995
issn:
- 0105-4538
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'PIPE‐cloned human IgE and IgG4 antibodies: New tools for investigating cow''s
milk allergy and tolerance'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 76
year: '2021'
...
---
_id: '10838'
abstract:
- lang: eng
text: Combining hybrid zone analysis with genomic data is a promising approach to
understanding the genomic basis of adaptive divergence. It allows for the identification
of genomic regions underlying barriers to gene flow. It also provides insights
into spatial patterns of allele frequency change, informing about the interplay
between environmental factors, dispersal and selection. However, when only a single
hybrid zone is analysed, it is difficult to separate patterns generated by selection
from those resulting from chance. Therefore, it is beneficial to look for repeatable
patterns across replicate hybrid zones in the same system. We applied this approach
to the marine snail Littorina saxatilis, which contains two ecotypes, adapted
to wave-exposed rocks vs. high-predation boulder fields. The existence of numerous
hybrid zones between ecotypes offered the opportunity to test for the repeatability
of genomic architectures and spatial patterns of divergence. We sampled and phenotyped
snails from seven replicate hybrid zones on the Swedish west coast and genotyped
them for thousands of single nucleotide polymorphisms. Shell shape and size showed
parallel clines across all zones. Many genomic regions showing steep clines and/or
high differentiation were shared among hybrid zones, consistent with a common
evolutionary history and extensive gene flow between zones, and supporting the
importance of these regions for divergence. In particular, we found that several
large putative inversions contribute to divergence in all locations. Additionally,
we found evidence for consistent displacement of clines from the boulder–rock
transition. Our results demonstrate patterns of spatial variation that would not
be accessible without continuous spatial sampling, a large genomic data set and
replicate hybrid zones.
acknowledgement: "We thank everyone who helped with fieldwork, snail processing and
DNA extractions, particularly Laura Brettell, Mårten Duvetorp, Juan Galindo, Anne-Lise
Liabot, Mark Ravinet, Irena Senčić and Zuzanna Zagrodzka. We are also grateful to
Edinburgh Genomics for library preparation and sequencing, to Stuart Baird and Mark
Ravinet for helpful discussions, and to three anonymous reviewers for their constructive
comments. This work was supported by the Natural Environment Research Council (NE/K014021/1),
the European Research Council (AdG-693030-BARRIERS), Swedish Research Councils Formas
and Vetenskapsrådet through a Linnaeus grant to the Centre for Marine Evolutionary
Biology (217-2008-1719), the European Regional Development Fund (POCI-01-0145-FEDER-030628),
and the Fundação para a iência e a Tecnologia,\r\nPortugal (PTDC/BIA-EVL/\r\n30628/2017).
A.M.W. and R.F. were\r\nfunded by the European Union’s Horizon 2020 research and
innovation\r\nprogramme under Marie Skłodowska-Curie\r\ngrant agreements\r\nno.
754411/797747 and no. 706376, respectively."
article_processing_charge: No
article_type: original
author:
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
- first_name: Rui
full_name: Faria, Rui
last_name: Faria
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
- first_name: Roger
full_name: Butlin, Roger
last_name: Butlin
citation:
ama: Westram AM, Faria R, Johannesson K, Butlin R. Using replicate hybrid zones
to understand the genomic basis of adaptive divergence. Molecular Ecology.
2021;30(15):3797-3814. doi:10.1111/mec.15861
apa: Westram, A. M., Faria, R., Johannesson, K., & Butlin, R. (2021). Using
replicate hybrid zones to understand the genomic basis of adaptive divergence.
Molecular Ecology. Wiley. https://doi.org/10.1111/mec.15861
chicago: Westram, Anja M, Rui Faria, Kerstin Johannesson, and Roger Butlin. “Using
Replicate Hybrid Zones to Understand the Genomic Basis of Adaptive Divergence.”
Molecular Ecology. Wiley, 2021. https://doi.org/10.1111/mec.15861.
ieee: A. M. Westram, R. Faria, K. Johannesson, and R. Butlin, “Using replicate hybrid
zones to understand the genomic basis of adaptive divergence,” Molecular Ecology,
vol. 30, no. 15. Wiley, pp. 3797–3814, 2021.
ista: Westram AM, Faria R, Johannesson K, Butlin R. 2021. Using replicate hybrid
zones to understand the genomic basis of adaptive divergence. Molecular Ecology.
30(15), 3797–3814.
mla: Westram, Anja M., et al. “Using Replicate Hybrid Zones to Understand the Genomic
Basis of Adaptive Divergence.” Molecular Ecology, vol. 30, no. 15, Wiley,
2021, pp. 3797–814, doi:10.1111/mec.15861.
short: A.M. Westram, R. Faria, K. Johannesson, R. Butlin, Molecular Ecology 30 (2021)
3797–3814.
corr_author: '1'
date_created: 2022-03-08T11:28:32Z
date_published: 2021-08-01T00:00:00Z
date_updated: 2024-10-09T21:01:47Z
day: '01'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1111/mec.15861
external_id:
isi:
- '000669439700001'
pmid:
- '33638231'
file:
- access_level: open_access
checksum: d5611f243ceb63a0e091d6662ebd9cda
content_type: application/pdf
creator: dernst
date_created: 2022-03-08T11:31:30Z
date_updated: 2022-03-08T11:31:30Z
file_id: '10839'
file_name: 2021_MolecularEcology_Westram.pdf
file_size: 1726548
relation: main_file
success: 1
file_date_updated: 2022-03-08T11:31:30Z
has_accepted_license: '1'
intvolume: ' 30'
isi: 1
issue: '15'
keyword:
- Genetics
- Ecology
- Evolution
- Behavior and Systematics
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 3797-3814
pmid: 1
publication: Molecular Ecology
publication_identifier:
eissn:
- 1365-294X
issn:
- 0962-1083
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Using replicate hybrid zones to understand the genomic basis of adaptive divergence
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 30
year: '2021'
...
---
_id: '10847'
abstract:
- lang: eng
text: 'We study the two-player zero-sum extension of the partially observable stochastic
shortest-path problem where one agent has only partial information about the environment.
We formulate this problem as a partially observable stochastic game (POSG): given
a set of target states and negative rewards for each transition, the player with
imperfect information maximizes the expected undiscounted total reward until a
target state is reached. The second player with the perfect information aims for
the opposite. We base our formalism on POSGs with one-sided observability (OS-POSGs)
and give the following contributions: (1) we introduce a novel heuristic search
value iteration algorithm that iteratively solves depth-limited variants of the
game, (2) we derive the bound on the depth guaranteeing an arbitrary precision,
(3) we propose a novel upper-bound estimation that allows early terminations,
and (4) we experimentally evaluate the algorithm on a pursuit-evasion game.'
acknowledgement: "This research was supported by the Czech Science Foundation (no.
19-24384Y), by the OP VVV MEYS funded project CZ.02.1.01/0.0/0.0/16 019/0000765
“Research Center for Informatics”, by the ERC CoG 863818 (ForM-SMArt), and by the
Combat Capabilities Development Command Army Research Laboratory and was accomplished
under Cooperative\r\nAgreement Number W911NF-13-2-0045 (ARL Cyber Security CRA).
The views and conclusions contained in this document are those of the authors and
should not be interpreted as\r\nrepresenting the official policies, either expressed
or implied, of the Combat Capabilities Development Command Army Research Laboratory
or the U.S. Government. The U.S. Government is authorized to reproduce and distribute
reprints for Government purposes not withstanding any copyright notation here on. "
article_processing_charge: No
author:
- first_name: Petr
full_name: Tomášek, Petr
last_name: Tomášek
- first_name: Karel
full_name: Horák, Karel
last_name: Horák
- first_name: Aditya
full_name: Aradhye, Aditya
last_name: Aradhye
- first_name: Branislav
full_name: Bošanský, Branislav
last_name: Bošanský
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
citation:
ama: 'Tomášek P, Horák K, Aradhye A, Bošanský B, Chatterjee K. Solving partially
observable stochastic shortest-path games. In: 30th International Joint Conference
on Artificial Intelligence. International Joint Conferences on Artificial
Intelligence; 2021:4182-4189. doi:10.24963/ijcai.2021/575'
apa: 'Tomášek, P., Horák, K., Aradhye, A., Bošanský, B., & Chatterjee, K. (2021).
Solving partially observable stochastic shortest-path games. In 30th International
Joint Conference on Artificial Intelligence (pp. 4182–4189). Virtual, Online:
International Joint Conferences on Artificial Intelligence. https://doi.org/10.24963/ijcai.2021/575'
chicago: Tomášek, Petr, Karel Horák, Aditya Aradhye, Branislav Bošanský, and Krishnendu
Chatterjee. “Solving Partially Observable Stochastic Shortest-Path Games.” In
30th International Joint Conference on Artificial Intelligence, 4182–89.
International Joint Conferences on Artificial Intelligence, 2021. https://doi.org/10.24963/ijcai.2021/575.
ieee: P. Tomášek, K. Horák, A. Aradhye, B. Bošanský, and K. Chatterjee, “Solving
partially observable stochastic shortest-path games,” in 30th International
Joint Conference on Artificial Intelligence, Virtual, Online, 2021, pp. 4182–4189.
ista: 'Tomášek P, Horák K, Aradhye A, Bošanský B, Chatterjee K. 2021. Solving partially
observable stochastic shortest-path games. 30th International Joint Conference
on Artificial Intelligence. IJCAI: International Joint Conferences on Artificial
Intelligence, 4182–4189.'
mla: Tomášek, Petr, et al. “Solving Partially Observable Stochastic Shortest-Path
Games.” 30th International Joint Conference on Artificial Intelligence,
International Joint Conferences on Artificial Intelligence, 2021, pp. 4182–89,
doi:10.24963/ijcai.2021/575.
short: P. Tomášek, K. Horák, A. Aradhye, B. Bošanský, K. Chatterjee, in:, 30th International
Joint Conference on Artificial Intelligence, International Joint Conferences on
Artificial Intelligence, 2021, pp. 4182–4189.
conference:
end_date: 2021-08-27
location: Virtual, Online
name: 'IJCAI: International Joint Conferences on Artificial Intelligence'
start_date: 2021-08-19
date_created: 2022-03-13T23:01:47Z
date_published: 2021-09-01T00:00:00Z
date_updated: 2026-06-18T10:41:02Z
day: '01'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.24963/ijcai.2021/575
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.24963/ijcai.2021/575
month: '09'
oa: 1
oa_version: Published Version
page: 4182-4189
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '863818'
name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
publication: 30th International Joint Conference on Artificial Intelligence
publication_identifier:
isbn:
- '9780999241196'
issn:
- 1045-0823
publication_status: published
publisher: International Joint Conferences on Artificial Intelligence
quality_controlled: '1'
scopus_import: '1'
status: public
title: Solving partially observable stochastic shortest-path games
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '10852'
abstract:
- lang: eng
text: ' We review old and new results on the Fröhlich polaron model. The discussion
includes the validity of the (classical) Pekar approximation in the strong coupling
limit, quantum corrections to this limit, as well as the divergence of the effective
polaron mass.'
acknowledgement: This work was supported by the European Research Council (ERC) under
the Euro-pean Union’s Horizon 2020 research and innovation programme (grant agreementNo.
694227).
article_number: '2060012'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Seiringer R. The polaron at strong coupling. Reviews in Mathematical Physics.
2021;33(01). doi:10.1142/s0129055x20600120
apa: Seiringer, R. (2021). The polaron at strong coupling. Reviews in Mathematical
Physics. World Scientific Publishing. https://doi.org/10.1142/s0129055x20600120
chicago: Seiringer, Robert. “The Polaron at Strong Coupling.” Reviews in Mathematical
Physics. World Scientific Publishing, 2021. https://doi.org/10.1142/s0129055x20600120.
ieee: R. Seiringer, “The polaron at strong coupling,” Reviews in Mathematical
Physics, vol. 33, no. 01. World Scientific Publishing, 2021.
ista: Seiringer R. 2021. The polaron at strong coupling. Reviews in Mathematical
Physics. 33(01), 2060012.
mla: Seiringer, Robert. “The Polaron at Strong Coupling.” Reviews in Mathematical
Physics, vol. 33, no. 01, 2060012, World Scientific Publishing, 2021, doi:10.1142/s0129055x20600120.
short: R. Seiringer, Reviews in Mathematical Physics 33 (2021).
corr_author: '1'
date_created: 2022-03-18T08:11:34Z
date_published: 2021-02-01T00:00:00Z
date_updated: 2025-04-14T07:26:58Z
day: '01'
department:
- _id: RoSe
doi: 10.1142/s0129055x20600120
ec_funded: 1
external_id:
arxiv:
- '1912.12509'
isi:
- '000613313200013'
intvolume: ' 33'
isi: 1
issue: '01'
keyword:
- Mathematical Physics
- Statistical and Nonlinear Physics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1912.12509
month: '02'
oa: 1
oa_version: Preprint
project:
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694227'
name: Analysis of quantum many-body systems
publication: Reviews in Mathematical Physics
publication_identifier:
eissn:
- 1793-6659
issn:
- 0129-055X
publication_status: published
publisher: World Scientific Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: The polaron at strong coupling
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 33
year: '2021'
...
---
_id: '10853'
abstract:
- lang: eng
text: Dynamic Connectivity is a fundamental algorithmic graph problem, motivated
by a wide range of applications to social and communication networks and used
as a building block in various other algorithms, such as the bi-connectivity and
the dynamic minimal spanning tree problems. In brief, we wish to maintain the
connected components of the graph under dynamic edge insertions and deletions.
In the sequential case, the problem has been well-studied from both theoretical
and practical perspectives. However, much less is known about efficient concurrent
solutions to this problem. This is the gap we address in this paper. We start
from one of the classic data structures used to solve this problem, the Euler
Tour Tree. Our first contribution is a non-blocking single-writer implementation
of it. We leverage this data structure to obtain the first truly concurrent generalization
of dynamic connectivity, which preserves the time complexity of its sequential
counterpart, but is also scalable in practice. To achieve this, we rely on three
main techniques. The first is to ensure that connectivity queries, which usually
dominate real-world workloads, are non-blocking. The second non-trivial technique
expands the above idea by making all queries that do not change the connectivity
structure non-blocking. The third ingredient is applying fine-grained locking
for updating the connected components, which allows operations on disjoint components
to occur in parallel. We evaluate the resulting algorithm on various workloads,
executing on both real and synthetic graphs. The results show the efficiency of
each of the proposed optimizations; the most efficient variant improves the performance
of a coarse-grained based implementation on realistic scenarios up to 6x on average
and up to 30x when connectivity queries dominate.
article_processing_charge: No
arxiv: 1
author:
- first_name: Alexander
full_name: Fedorov, Alexander
last_name: Fedorov
- first_name: Nikita
full_name: Koval, Nikita
last_name: Koval
- first_name: Dan-Adrian
full_name: Alistarh, Dan-Adrian
id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
last_name: Alistarh
orcid: 0000-0003-3650-940X
citation:
ama: 'Fedorov A, Koval N, Alistarh D-A. A scalable concurrent algorithm for dynamic
connectivity. In: Proceedings of the 33rd ACM Symposium on Parallelism in Algorithms
and Architectures. Association for Computing Machinery; 2021:208-220. doi:10.1145/3409964.3461810'
apa: 'Fedorov, A., Koval, N., & Alistarh, D.-A. (2021). A scalable concurrent
algorithm for dynamic connectivity. In Proceedings of the 33rd ACM Symposium
on Parallelism in Algorithms and Architectures (pp. 208–220). Virtual, Online:
Association for Computing Machinery. https://doi.org/10.1145/3409964.3461810'
chicago: Fedorov, Alexander, Nikita Koval, and Dan-Adrian Alistarh. “A Scalable
Concurrent Algorithm for Dynamic Connectivity.” In Proceedings of the 33rd
ACM Symposium on Parallelism in Algorithms and Architectures, 208–20. Association
for Computing Machinery, 2021. https://doi.org/10.1145/3409964.3461810.
ieee: A. Fedorov, N. Koval, and D.-A. Alistarh, “A scalable concurrent algorithm
for dynamic connectivity,” in Proceedings of the 33rd ACM Symposium on Parallelism
in Algorithms and Architectures, Virtual, Online, 2021, pp. 208–220.
ista: 'Fedorov A, Koval N, Alistarh D-A. 2021. A scalable concurrent algorithm for
dynamic connectivity. Proceedings of the 33rd ACM Symposium on Parallelism in
Algorithms and Architectures. SPAA: Symposium on Parallelism in Algorithms and
Architectures, 208–220.'
mla: Fedorov, Alexander, et al. “A Scalable Concurrent Algorithm for Dynamic Connectivity.”
Proceedings of the 33rd ACM Symposium on Parallelism in Algorithms and Architectures,
Association for Computing Machinery, 2021, pp. 208–20, doi:10.1145/3409964.3461810.
short: A. Fedorov, N. Koval, D.-A. Alistarh, in:, Proceedings of the 33rd ACM Symposium
on Parallelism in Algorithms and Architectures, Association for Computing Machinery,
2021, pp. 208–220.
conference:
end_date: 2021-07-08
location: Virtual, Online
name: 'SPAA: Symposium on Parallelism in Algorithms and Architectures'
start_date: 2021-07-06
date_created: 2022-03-18T08:21:47Z
date_published: 2021-07-01T00:00:00Z
date_updated: 2022-03-18T08:45:46Z
day: '01'
department:
- _id: DaAl
doi: 10.1145/3409964.3461810
external_id:
arxiv:
- '2105.08098'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2105.08098
month: '07'
oa: 1
oa_version: Preprint
page: 208-220
publication: Proceedings of the 33rd ACM Symposium on Parallelism in Algorithms and
Architectures
publication_identifier:
isbn:
- '9781450380706'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: A scalable concurrent algorithm for dynamic connectivity
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '10854'
abstract:
- lang: eng
text: "Consider a distributed task where the communication network is fixed but
the local inputs given to the nodes of the distributed system may change over
time. In this work, we explore the following question: if some of the local inputs
change, can an existing solution be updated efficiently, in a dynamic and distributed
manner?\r\nTo address this question, we define the batch dynamic CONGEST model
in which we are given a bandwidth-limited communication network and a dynamic
edge labelling defines the problem input. The task is to maintain a solution to
a graph problem on the labelled graph under batch changes. We investigate, when
a batch of alpha edge label changes arrive, - how much time as a function of alpha
we need to update an existing solution, and - how much information the nodes have
to keep in local memory between batches in order to update the solution quickly.\r\nOur
work lays the foundations for the theory of input-dynamic distributed network
algorithms. We give a general picture of the complexity landscape in this model,
design both universal algorithms and algorithms for concrete problems, and present
a general framework for lower bounds. The diverse time complexity of our model
spans from constant time, through time polynomial in alpha, and to alpha time,
which we show to be enough for any task."
acknowledgement: We thank Jukka Suomela for discussions. We also thank our shepherd
Mohammad Hajiesmaili and the reviewers for their time and suggestions on how to
improve the paper. This project has received funding from the European Research
Council (ERC) under the European Union’s Horizon 2020 research and innovation programme
(grant agreement No 805223 ScaleML), from the European Union’s Horizon 2020 research
and innovation programme under the Marie Skłodowska–Curie grant agreement No. 840605,
from the Vienna Science and Technology Fund (WWTF) project WHATIF, ICT19-045, 2020-2024,
and from the Austrian Science Fund (FWF) and netIDEE SCIENCE project P 33775-N.
article_processing_charge: No
arxiv: 1
author:
- first_name: Klaus-Tycho
full_name: Foerster, Klaus-Tycho
last_name: Foerster
- first_name: Janne
full_name: Korhonen, Janne
id: C5402D42-15BC-11E9-A202-CA2BE6697425
last_name: Korhonen
- first_name: Ami
full_name: Paz, Ami
last_name: Paz
- first_name: Joel
full_name: Rybicki, Joel
id: 334EFD2E-F248-11E8-B48F-1D18A9856A87
last_name: Rybicki
orcid: 0000-0002-6432-6646
- first_name: Stefan
full_name: Schmid, Stefan
last_name: Schmid
citation:
ama: 'Foerster K-T, Korhonen J, Paz A, Rybicki J, Schmid S. Input-dynamic distributed
algorithms for communication networks. In: Abstract Proceedings of the 2021
ACM SIGMETRICS / International Conference on Measurement and Modeling of Computer
Systems. Association for Computing Machinery; 2021:71-72. doi:10.1145/3410220.3453923'
apa: 'Foerster, K.-T., Korhonen, J., Paz, A., Rybicki, J., & Schmid, S. (2021).
Input-dynamic distributed algorithms for communication networks. In Abstract
Proceedings of the 2021 ACM SIGMETRICS / International Conference on Measurement
and Modeling of Computer Systems (pp. 71–72). Virtual, Online: Association
for Computing Machinery. https://doi.org/10.1145/3410220.3453923'
chicago: Foerster, Klaus-Tycho, Janne Korhonen, Ami Paz, Joel Rybicki, and Stefan
Schmid. “Input-Dynamic Distributed Algorithms for Communication Networks.” In
Abstract Proceedings of the 2021 ACM SIGMETRICS / International Conference
on Measurement and Modeling of Computer Systems, 71–72. Association for Computing
Machinery, 2021. https://doi.org/10.1145/3410220.3453923.
ieee: K.-T. Foerster, J. Korhonen, A. Paz, J. Rybicki, and S. Schmid, “Input-dynamic
distributed algorithms for communication networks,” in Abstract Proceedings
of the 2021 ACM SIGMETRICS / International Conference on Measurement and Modeling
of Computer Systems, Virtual, Online, 2021, pp. 71–72.
ista: 'Foerster K-T, Korhonen J, Paz A, Rybicki J, Schmid S. 2021. Input-dynamic
distributed algorithms for communication networks. Abstract Proceedings of the
2021 ACM SIGMETRICS / International Conference on Measurement and Modeling of
Computer Systems. SIGMETRICS: International Conference on Measurement and Modeling
of Computer Systems, 71–72.'
mla: Foerster, Klaus-Tycho, et al. “Input-Dynamic Distributed Algorithms for Communication
Networks.” Abstract Proceedings of the 2021 ACM SIGMETRICS / International
Conference on Measurement and Modeling of Computer Systems, Association for
Computing Machinery, 2021, pp. 71–72, doi:10.1145/3410220.3453923.
short: K.-T. Foerster, J. Korhonen, A. Paz, J. Rybicki, S. Schmid, in:, Abstract
Proceedings of the 2021 ACM SIGMETRICS / International Conference on Measurement
and Modeling of Computer Systems, Association for Computing Machinery, 2021, pp.
71–72.
conference:
end_date: 2021-06-18
location: Virtual, Online
name: 'SIGMETRICS: International Conference on Measurement and Modeling of Computer
Systems'
start_date: 2021-06-14
date_created: 2022-03-18T08:48:41Z
date_published: 2021-05-01T00:00:00Z
date_updated: 2025-04-14T13:52:09Z
day: '01'
department:
- _id: DaAl
doi: 10.1145/3410220.3453923
ec_funded: 1
external_id:
arxiv:
- '2005.07637'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2005.07637
month: '05'
oa: 1
oa_version: Preprint
page: 71-72
project:
- _id: 268A44D6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '805223'
name: Elastic Coordination for Scalable Machine Learning
- _id: 26A5D39A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '840605'
name: Coordination in constrained and natural distributed systems
publication: Abstract Proceedings of the 2021 ACM SIGMETRICS / International Conference
on Measurement and Modeling of Computer Systems
publication_identifier:
isbn:
- '9781450380720'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
related_material:
record:
- id: '10855'
relation: extended_version
status: public
scopus_import: '1'
status: public
title: Input-dynamic distributed algorithms for communication networks
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '10855'
abstract:
- lang: eng
text: 'Consider a distributed task where the communication network is fixed but
the local inputs given to the nodes of the distributed system may change over
time. In this work, we explore the following question: if some of the local inputs
change, can an existing solution be updated efficiently, in a dynamic and distributed
manner? To address this question, we define the batch dynamic \congest model in
which we are given a bandwidth-limited communication network and a dynamic edge
labelling defines the problem input. The task is to maintain a solution to a graph
problem on the labeled graph under batch changes. We investigate, when a batch
of α edge label changes arrive, \beginitemize \item how much time as a function
of α we need to update an existing solution, and \item how much information the
nodes have to keep in local memory between batches in order to update the solution
quickly. \enditemize Our work lays the foundations for the theory of input-dynamic
distributed network algorithms. We give a general picture of the complexity landscape
in this model, design both universal algorithms and algorithms for concrete problems,
and present a general framework for lower bounds. In particular, we derive non-trivial
upper bounds for two selected, contrasting problems: maintaining a minimum spanning
tree and detecting cliques.'
acknowledgement: "We thank Jukka Suomela for discussions. We also thank our shepherd
Mohammad Hajiesmaili\r\nand the reviewers for their time and suggestions on how
to improve the paper. This project\r\nhas received funding from the European Research
Council (ERC) under the European Union’s\r\nHorizon 2020 research and innovation
programme (grant agreement No 805223 ScaleML), from the European Union’s Horizon
2020 research and innovation programme under the Marie\r\nSk lodowska–Curie grant
agreement No. 840605, from the Vienna Science and Technology Fund (WWTF) project
WHATIF, ICT19-045, 2020-2024, and from the Austrian Science Fund (FWF) and netIDEE
SCIENCE project P 33775-N."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Klaus-Tycho
full_name: Foerster, Klaus-Tycho
last_name: Foerster
- first_name: Janne
full_name: Korhonen, Janne
id: C5402D42-15BC-11E9-A202-CA2BE6697425
last_name: Korhonen
- first_name: Ami
full_name: Paz, Ami
last_name: Paz
- first_name: Joel
full_name: Rybicki, Joel
id: 334EFD2E-F248-11E8-B48F-1D18A9856A87
last_name: Rybicki
orcid: 0000-0002-6432-6646
- first_name: Stefan
full_name: Schmid, Stefan
last_name: Schmid
citation:
ama: Foerster K-T, Korhonen J, Paz A, Rybicki J, Schmid S. Input-dynamic distributed
algorithms for communication networks. Proceedings of the ACM on Measurement
and Analysis of Computing Systems. 2021;5(1):1-33. doi:10.1145/3447384
apa: Foerster, K.-T., Korhonen, J., Paz, A., Rybicki, J., & Schmid, S. (2021).
Input-dynamic distributed algorithms for communication networks. Proceedings
of the ACM on Measurement and Analysis of Computing Systems. Association for
Computing Machinery. https://doi.org/10.1145/3447384
chicago: Foerster, Klaus-Tycho, Janne Korhonen, Ami Paz, Joel Rybicki, and Stefan
Schmid. “Input-Dynamic Distributed Algorithms for Communication Networks.” Proceedings
of the ACM on Measurement and Analysis of Computing Systems. Association for
Computing Machinery, 2021. https://doi.org/10.1145/3447384.
ieee: K.-T. Foerster, J. Korhonen, A. Paz, J. Rybicki, and S. Schmid, “Input-dynamic
distributed algorithms for communication networks,” Proceedings of the ACM
on Measurement and Analysis of Computing Systems, vol. 5, no. 1. Association
for Computing Machinery, pp. 1–33, 2021.
ista: Foerster K-T, Korhonen J, Paz A, Rybicki J, Schmid S. 2021. Input-dynamic
distributed algorithms for communication networks. Proceedings of the ACM on Measurement
and Analysis of Computing Systems. 5(1), 1–33.
mla: Foerster, Klaus-Tycho, et al. “Input-Dynamic Distributed Algorithms for Communication
Networks.” Proceedings of the ACM on Measurement and Analysis of Computing
Systems, vol. 5, no. 1, Association for Computing Machinery, 2021, pp. 1–33,
doi:10.1145/3447384.
short: K.-T. Foerster, J. Korhonen, A. Paz, J. Rybicki, S. Schmid, Proceedings of
the ACM on Measurement and Analysis of Computing Systems 5 (2021) 1–33.
date_created: 2022-03-18T09:10:27Z
date_published: 2021-03-01T00:00:00Z
date_updated: 2025-04-14T13:52:09Z
day: '01'
department:
- _id: DaAl
doi: 10.1145/3447384
ec_funded: 1
external_id:
arxiv:
- '2005.07637'
intvolume: ' 5'
issue: '1'
keyword:
- Computer Networks and Communications
- Hardware and Architecture
- Safety
- Risk
- Reliability and Quality
- Computer Science (miscellaneous)
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2005.07637
month: '03'
oa: 1
oa_version: Preprint
page: 1-33
project:
- _id: 26A5D39A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '840605'
name: Coordination in constrained and natural distributed systems
- _id: 268A44D6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '805223'
name: Elastic Coordination for Scalable Machine Learning
publication: Proceedings of the ACM on Measurement and Analysis of Computing Systems
publication_identifier:
issn:
- 2476-1249
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
related_material:
record:
- id: '10854'
relation: shorter_version
status: public
scopus_import: '1'
status: public
title: Input-dynamic distributed algorithms for communication networks
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2021'
...
---
_id: '10856'
abstract:
- lang: eng
text: "We study the properties of the maximal volume k-dimensional sections of the
n-dimensional cube [−1, 1]n. We obtain a first order necessary condition for a
k-dimensional subspace to be a local maximizer of the volume of such sections,
which we formulate in a geometric way. We estimate the length of the projection
of a vector of the standard basis of Rn onto a k-dimensional subspace that maximizes
the volume of the intersection. We \x1Cnd the optimal upper bound on the volume
of a planar section of the cube [−1, 1]n , n ≥ 2."
acknowledgement: "The authors acknowledge the support of the grant of the Russian
Government N 075-15-\r\n2019-1926. G.I.was supported also by the SwissNational Science
Foundation grant 200021-179133. The authors are very grateful to the anonymous reviewer
for valuable remarks."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Grigory
full_name: Ivanov, Grigory
id: 87744F66-5C6F-11EA-AFE0-D16B3DDC885E
last_name: Ivanov
- first_name: Igor
full_name: Tsiutsiurupa, Igor
last_name: Tsiutsiurupa
citation:
ama: Ivanov G, Tsiutsiurupa I. On the volume of sections of the cube. Analysis
and Geometry in Metric Spaces. 2021;9(1):1-18. doi:10.1515/agms-2020-0103
apa: Ivanov, G., & Tsiutsiurupa, I. (2021). On the volume of sections of the
cube. Analysis and Geometry in Metric Spaces. De Gruyter. https://doi.org/10.1515/agms-2020-0103
chicago: Ivanov, Grigory, and Igor Tsiutsiurupa. “On the Volume of Sections of the
Cube.” Analysis and Geometry in Metric Spaces. De Gruyter, 2021. https://doi.org/10.1515/agms-2020-0103.
ieee: G. Ivanov and I. Tsiutsiurupa, “On the volume of sections of the cube,” Analysis
and Geometry in Metric Spaces, vol. 9, no. 1. De Gruyter, pp. 1–18, 2021.
ista: Ivanov G, Tsiutsiurupa I. 2021. On the volume of sections of the cube. Analysis
and Geometry in Metric Spaces. 9(1), 1–18.
mla: Ivanov, Grigory, and Igor Tsiutsiurupa. “On the Volume of Sections of the Cube.”
Analysis and Geometry in Metric Spaces, vol. 9, no. 1, De Gruyter, 2021,
pp. 1–18, doi:10.1515/agms-2020-0103.
short: G. Ivanov, I. Tsiutsiurupa, Analysis and Geometry in Metric Spaces 9 (2021)
1–18.
date_created: 2022-03-18T09:25:14Z
date_published: 2021-01-29T00:00:00Z
date_updated: 2023-08-17T07:07:58Z
day: '29'
ddc:
- '510'
department:
- _id: UlWa
doi: 10.1515/agms-2020-0103
external_id:
arxiv:
- '2004.02674'
isi:
- '000734286800001'
file:
- access_level: open_access
checksum: 7e615ac8489f5eae580b6517debfdc53
content_type: application/pdf
creator: dernst
date_created: 2022-03-18T09:31:59Z
date_updated: 2022-03-18T09:31:59Z
file_id: '10857'
file_name: 2021_AnalysisMetricSpaces_Ivanov.pdf
file_size: 789801
relation: main_file
success: 1
file_date_updated: 2022-03-18T09:31:59Z
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
issue: '1'
keyword:
- Applied Mathematics
- Geometry and Topology
- Analysis
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 1-18
publication: Analysis and Geometry in Metric Spaces
publication_identifier:
issn:
- 2299-3274
publication_status: published
publisher: De Gruyter
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the volume of sections of the cube
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 9
year: '2021'
...
---
_id: '10858'
abstract:
- lang: eng
text: The cost-effective conversion of low-grade heat into electricity using thermoelectric
devices requires developing alternative materials and material processing technologies
able to reduce the currently high device manufacturing costs. In this direction,
thermoelectric materials that do not rely on rare or toxic elements such as tellurium
or lead need to be produced using high-throughput technologies not involving high
temperatures and long processes. Bi2Se3 is an obvious possible Te-free alternative
to Bi2Te3 for ambient temperature thermoelectric applications, but its performance
is still low for practical applications, and additional efforts toward finding
proper dopants are required. Here, we report a scalable method to produce Bi2Se3
nanosheets at low synthesis temperatures. We studied the influence of different
dopants on the thermoelectric properties of this material. Among the elements
tested, we demonstrated that Sn doping resulted in the best performance. Sn incorporation
resulted in a significant improvement to the Bi2Se3 Seebeck coefficient and a
reduction in the thermal conductivity in the direction of the hot-press axis,
resulting in an overall 60% improvement in the thermoelectric figure of merit
of Bi2Se3.
acknowledgement: "M.L., Y.Z., T.Z. and K.X. thank the China Scholarship Council for
their scholarship\r\nsupport. Y.L. acknowledges funding from the European Union’s
Horizon 2020 research and\r\ninnovation program under the Marie Sklodowska-Curie
grant agreement No. 754411. J.L. thanks the ICREA Academia program and projects
MICINN/FEDER RTI2018-093996-B-C31 and G.C. 2017 SGR 128. ICN2 acknowledges funding
from the Generalitat de Catalunya 2017 SGR 327 and the Spanish MINECO ENE2017-85087-C3."
article_number: '1827'
article_processing_charge: No
article_type: original
author:
- first_name: Mengyao
full_name: Li, Mengyao
last_name: Li
- first_name: Yu
full_name: Zhang, Yu
last_name: Zhang
- first_name: Ting
full_name: Zhang, Ting
last_name: Zhang
- first_name: Yong
full_name: Zuo, Yong
last_name: Zuo
- first_name: Ke
full_name: Xiao, Ke
last_name: Xiao
- first_name: Jordi
full_name: Arbiol, Jordi
last_name: Arbiol
- first_name: Jordi
full_name: Llorca, Jordi
last_name: Llorca
- first_name: Yu
full_name: Liu, Yu
id: 2A70014E-F248-11E8-B48F-1D18A9856A87
last_name: Liu
orcid: 0000-0001-7313-6740
- first_name: Andreu
full_name: Cabot, Andreu
last_name: Cabot
citation:
ama: Li M, Zhang Y, Zhang T, et al. Enhanced thermoelectric performance of n-type
Bi2Se3 nanosheets through Sn doping. Nanomaterials. 2021;11(7). doi:10.3390/nano11071827
apa: Li, M., Zhang, Y., Zhang, T., Zuo, Y., Xiao, K., Arbiol, J., … Cabot, A. (2021).
Enhanced thermoelectric performance of n-type Bi2Se3 nanosheets through Sn doping.
Nanomaterials. MDPI. https://doi.org/10.3390/nano11071827
chicago: Li, Mengyao, Yu Zhang, Ting Zhang, Yong Zuo, Ke Xiao, Jordi Arbiol, Jordi
Llorca, Yu Liu, and Andreu Cabot. “Enhanced Thermoelectric Performance of N-Type
Bi2Se3 Nanosheets through Sn Doping.” Nanomaterials. MDPI, 2021. https://doi.org/10.3390/nano11071827.
ieee: M. Li et al., “Enhanced thermoelectric performance of n-type Bi2Se3
nanosheets through Sn doping,” Nanomaterials, vol. 11, no. 7. MDPI, 2021.
ista: Li M, Zhang Y, Zhang T, Zuo Y, Xiao K, Arbiol J, Llorca J, Liu Y, Cabot A.
2021. Enhanced thermoelectric performance of n-type Bi2Se3 nanosheets through
Sn doping. Nanomaterials. 11(7), 1827.
mla: Li, Mengyao, et al. “Enhanced Thermoelectric Performance of N-Type Bi2Se3 Nanosheets
through Sn Doping.” Nanomaterials, vol. 11, no. 7, 1827, MDPI, 2021, doi:10.3390/nano11071827.
short: M. Li, Y. Zhang, T. Zhang, Y. Zuo, K. Xiao, J. Arbiol, J. Llorca, Y. Liu,
A. Cabot, Nanomaterials 11 (2021).
corr_author: '1'
date_created: 2022-03-18T09:45:02Z
date_published: 2021-07-14T00:00:00Z
date_updated: 2025-06-12T06:42:18Z
day: '14'
ddc:
- '540'
department:
- _id: MaIb
doi: 10.3390/nano11071827
ec_funded: 1
external_id:
isi:
- '000676570000001'
pmid:
- '34361214'
file:
- access_level: open_access
checksum: f28a8b5cf80f5605828359bb398463b0
content_type: application/pdf
creator: dernst
date_created: 2022-03-18T09:53:15Z
date_updated: 2022-03-18T09:53:15Z
file_id: '10859'
file_name: 2021_Nanomaterials_Li.pdf
file_size: 4867547
relation: main_file
success: 1
file_date_updated: 2022-03-18T09:53:15Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
issue: '7'
keyword:
- General Materials Science
- General Chemical Engineering
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Nanomaterials
publication_identifier:
issn:
- 2079-4991
publication_status: published
publisher: MDPI
quality_controlled: '1'
scopus_import: '1'
status: public
title: Enhanced thermoelectric performance of n-type Bi2Se3 nanosheets through Sn
doping
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2021'
...
---
_id: '10860'
abstract:
- lang: eng
text: A tight frame is the orthogonal projection of some orthonormal basis of Rn
onto Rk. We show that a set of vectors is a tight frame if and only if the set
of all cross products of these vectors is a tight frame. We reformulate a range
of problems on the volume of projections (or sections) of regular polytopes in
terms of tight frames and write a first-order necessary condition for local extrema
of these problems. As applications, we prove new results for the problem of maximization
of the volume of zonotopes.
acknowledgement: The author was supported by the Swiss National Science Foundation
grant 200021_179133. The author acknowledges the financial support from the Ministry
of Education and Science of the Russian Federation in the framework of MegaGrant
no. 075-15-2019-1926.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Grigory
full_name: Ivanov, Grigory
id: 87744F66-5C6F-11EA-AFE0-D16B3DDC885E
last_name: Ivanov
citation:
ama: Ivanov G. Tight frames and related geometric problems. Canadian Mathematical
Bulletin. 2021;64(4):942-963. doi:10.4153/s000843952000096x
apa: Ivanov, G. (2021). Tight frames and related geometric problems. Canadian
Mathematical Bulletin. Canadian Mathematical Society. https://doi.org/10.4153/s000843952000096x
chicago: Ivanov, Grigory. “Tight Frames and Related Geometric Problems.” Canadian
Mathematical Bulletin. Canadian Mathematical Society, 2021. https://doi.org/10.4153/s000843952000096x.
ieee: G. Ivanov, “Tight frames and related geometric problems,” Canadian Mathematical
Bulletin, vol. 64, no. 4. Canadian Mathematical Society, pp. 942–963, 2021.
ista: Ivanov G. 2021. Tight frames and related geometric problems. Canadian Mathematical
Bulletin. 64(4), 942–963.
mla: Ivanov, Grigory. “Tight Frames and Related Geometric Problems.” Canadian
Mathematical Bulletin, vol. 64, no. 4, Canadian Mathematical Society, 2021,
pp. 942–63, doi:10.4153/s000843952000096x.
short: G. Ivanov, Canadian Mathematical Bulletin 64 (2021) 942–963.
corr_author: '1'
date_created: 2022-03-18T09:55:59Z
date_published: 2021-12-18T00:00:00Z
date_updated: 2024-10-09T21:01:50Z
day: '18'
department:
- _id: UlWa
doi: 10.4153/s000843952000096x
external_id:
arxiv:
- '1804.10055'
isi:
- '000730165300021'
intvolume: ' 64'
isi: 1
issue: '4'
keyword:
- General Mathematics
- Tight frame
- Grassmannian
- zonotope
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1804.10055
month: '12'
oa: 1
oa_version: Preprint
page: 942-963
publication: Canadian Mathematical Bulletin
publication_identifier:
eissn:
- 1496-4287
issn:
- 0008-4395
publication_status: published
publisher: Canadian Mathematical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tight frames and related geometric problems
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 64
year: '2021'
...
---
_id: '10912'
abstract:
- lang: eng
text: Brain dynamics display collective phenomena as diverse as neuronal oscillations
and avalanches. Oscillations are rhythmic, with fluctuations occurring at a characteristic
scale, whereas avalanches are scale-free cascades of neural activity. Here we
show that such antithetic features can coexist in a very generic class of adaptive
neural networks. In the most simple yet fully microscopic model from this class
we make direct contact with human brain resting-state activity recordings via
tractable inference of the model's two essential parameters. The inferred model
quantitatively captures the dynamics over a broad range of scales, from single
sensor fluctuations, collective behaviors of nearly-synchronous extreme events
on multiple sensors, to neuronal avalanches unfolding over multiple sensors across
multiple time-bins. Importantly, the inferred parameters correlate with model-independent
signatures of "closeness to criticality", suggesting that the coexistence of scale-specific
(neural oscillations) and scale-free (neuronal avalanches) dynamics in brain activity
occurs close to a non-equilibrium critical point at the onset of self-sustained
oscillations.
acknowledgement: "FL acknowledges support from the European Union’s Horizon 2020 research
and innovation program under the Marie Sklodowska-Curie Grant Agreement No. 754411.
GT\r\nacknowledges the support of the Austrian Science Fund (FWF) under Stand-Alone
Grant\r\nNo. P34015."
article_processing_charge: No
arxiv: 1
author:
- first_name: Fabrizio
full_name: Lombardi, Fabrizio
id: A057D288-3E88-11E9-986D-0CF4E5697425
last_name: Lombardi
orcid: 0000-0003-2623-5249
- first_name: Selver
full_name: Pepic, Selver
id: F93245C4-C3CA-11E9-B4F0-C6F4E5697425
last_name: Pepic
- first_name: Oren
full_name: Shriki, Oren
last_name: Shriki
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
- first_name: Daniele
full_name: De Martino, Daniele
last_name: De Martino
citation:
ama: Lombardi F, Pepic S, Shriki O, Tkačik G, De Martino D. Quantifying the coexistence
of neuronal oscillations and avalanches. doi:10.48550/ARXIV.2108.06686
apa: Lombardi, F., Pepic, S., Shriki, O., Tkačik, G., & De Martino, D. (n.d.).
Quantifying the coexistence of neuronal oscillations and avalanches. arXiv. https://doi.org/10.48550/ARXIV.2108.06686
chicago: Lombardi, Fabrizio, Selver Pepic, Oren Shriki, Gašper Tkačik, and Daniele
De Martino. “Quantifying the Coexistence of Neuronal Oscillations and Avalanches.”
arXiv, n.d. https://doi.org/10.48550/ARXIV.2108.06686.
ieee: F. Lombardi, S. Pepic, O. Shriki, G. Tkačik, and D. De Martino, “Quantifying
the coexistence of neuronal oscillations and avalanches.” arXiv.
ista: Lombardi F, Pepic S, Shriki O, Tkačik G, De Martino D. Quantifying the coexistence
of neuronal oscillations and avalanches. 10.48550/ARXIV.2108.06686.
mla: Lombardi, Fabrizio, et al. Quantifying the Coexistence of Neuronal Oscillations
and Avalanches. arXiv, doi:10.48550/ARXIV.2108.06686.
short: F. Lombardi, S. Pepic, O. Shriki, G. Tkačik, D. De Martino, (n.d.).
date_created: 2022-03-21T11:41:28Z
date_published: 2021-08-17T00:00:00Z
date_updated: 2024-10-22T11:24:26Z
day: '17'
ddc:
- '570'
department:
- _id: GaTk
doi: 10.48550/ARXIV.2108.06686
ec_funded: 1
external_id:
arxiv:
- '2108.06686'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2108.06686
month: '08'
oa: 1
oa_version: Preprint
page: '37'
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: 626c45b5-2b32-11ec-9570-e509828c1ba6
grant_number: P34015
name: Efficient coding with biophysical realism
publication_status: submitted
publisher: arXiv
status: public
title: Quantifying the coexistence of neuronal oscillations and avalanches
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '11052'
abstract:
- lang: eng
text: In order to combat molecular damage, most cellular proteins undergo rapid
turnover. We have previously identified large nuclear protein assemblies that
can persist for years in post-mitotic tissues and are subject to age-related decline.
Here, we report that mitochondria can be long lived in the mouse brain and reveal
that specific mitochondrial proteins have half-lives longer than the average proteome.
These mitochondrial long-lived proteins (mitoLLPs) are core components of the
electron transport chain (ETC) and display increased longevity in respiratory
supercomplexes. We find that COX7C, a mitoLLP that forms a stable contact site
between complexes I and IV, is required for complex IV and supercomplex assembly.
Remarkably, even upon depletion of COX7C transcripts, ETC function is maintained
for days, effectively uncoupling mitochondrial function from ongoing transcription
of its mitoLLPs. Our results suggest that modulating protein longevity within
the ETC is critical for mitochondrial proteome maintenance and the robustness
of mitochondrial function.
article_processing_charge: No
article_type: original
author:
- first_name: Shefali
full_name: Krishna, Shefali
last_name: Krishna
- first_name: Rafael
full_name: Arrojo e Drigo, Rafael
last_name: Arrojo e Drigo
- first_name: Juliana S.
full_name: Capitanio, Juliana S.
last_name: Capitanio
- first_name: Ranjan
full_name: Ramachandra, Ranjan
last_name: Ramachandra
- first_name: Mark
full_name: Ellisman, Mark
last_name: Ellisman
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Krishna S, Arrojo e Drigo R, Capitanio JS, Ramachandra R, Ellisman M, Hetzer
M. Identification of long-lived proteins in the mitochondria reveals increased
stability of the electron transport chain. Developmental Cell. 2021;56(21):P2952-2965.e9.
doi:10.1016/j.devcel.2021.10.008
apa: Krishna, S., Arrojo e Drigo, R., Capitanio, J. S., Ramachandra, R., Ellisman,
M., & Hetzer, M. (2021). Identification of long-lived proteins in the mitochondria
reveals increased stability of the electron transport chain. Developmental
Cell. Elsevier. https://doi.org/10.1016/j.devcel.2021.10.008
chicago: Krishna, Shefali, Rafael Arrojo e Drigo, Juliana S. Capitanio, Ranjan Ramachandra,
Mark Ellisman, and Martin Hetzer. “Identification of Long-Lived Proteins in the
Mitochondria Reveals Increased Stability of the Electron Transport Chain.” Developmental
Cell. Elsevier, 2021. https://doi.org/10.1016/j.devcel.2021.10.008.
ieee: S. Krishna, R. Arrojo e Drigo, J. S. Capitanio, R. Ramachandra, M. Ellisman,
and M. Hetzer, “Identification of long-lived proteins in the mitochondria reveals
increased stability of the electron transport chain,” Developmental Cell,
vol. 56, no. 21. Elsevier, p. P2952–2965.e9, 2021.
ista: Krishna S, Arrojo e Drigo R, Capitanio JS, Ramachandra R, Ellisman M, Hetzer
M. 2021. Identification of long-lived proteins in the mitochondria reveals increased
stability of the electron transport chain. Developmental Cell. 56(21), P2952–2965.e9.
mla: Krishna, Shefali, et al. “Identification of Long-Lived Proteins in the Mitochondria
Reveals Increased Stability of the Electron Transport Chain.” Developmental
Cell, vol. 56, no. 21, Elsevier, 2021, p. P2952–2965.e9, doi:10.1016/j.devcel.2021.10.008.
short: S. Krishna, R. Arrojo e Drigo, J.S. Capitanio, R. Ramachandra, M. Ellisman,
M. Hetzer, Developmental Cell 56 (2021) P2952–2965.e9.
date_created: 2022-04-07T07:43:14Z
date_published: 2021-11-08T00:00:00Z
date_updated: 2025-12-15T10:01:56Z
day: '08'
department:
- _id: MaHe
doi: 10.1016/j.devcel.2021.10.008
extern: '1'
external_id:
pmid:
- '34715012'
intvolume: ' 56'
issue: '21'
keyword:
- Developmental Biology
- Cell Biology
- General Biochemistry
- Genetics and Molecular Biology
- Molecular Biology
language:
- iso: eng
month: '11'
oa_version: None
page: P2952-2965.e9
pmid: 1
publication: Developmental Cell
publication_identifier:
issn:
- 1534-5807
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Identification of long-lived proteins in the mitochondria reveals increased
stability of the electron transport chain
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 56
year: '2021'
...
---
_id: '11053'
abstract:
- lang: eng
text: Understanding basic mechanisms of aging holds great promise for developing
interventions that prevent or delay many age-related declines and diseases simultaneously
to increase human healthspan. However, a major confounding factor in aging research
is the heterogeneity of the aging process itself. At the organismal level, it
is clear that chronological age does not always predict biological age or susceptibility
to frailty or pathology. While genetics and environment are major factors driving
variable rates of aging, additional complexity arises because different organs,
tissues, and cell types are intrinsically heterogeneous and exhibit different
aging trajectories normally or in response to the stresses of the aging process
(e.g., damage accumulation). Tackling the heterogeneity of aging requires new
and specialized tools (e.g., single-cell analyses, mass spectrometry-based approaches,
and advanced imaging) to identify novel signatures of aging across scales. Cutting-edge
computational approaches are then needed to integrate these disparate datasets
and elucidate network interactions between known aging hallmarks. There is also
a need for improved, human cell-based models of aging to ensure that basic research
findings are relevant to human aging and healthspan interventions. The San Diego
Nathan Shock Center (SD-NSC) provides access to cutting-edge scientific resources
to facilitate the study of the heterogeneity of aging in general and to promote
the use of novel human cell models of aging. The center also has a robust Research
Development Core that funds pilot projects on the heterogeneity of aging and organizes
innovative training activities, including workshops and a personalized mentoring
program, to help investigators new to the aging field succeed. Finally, the SD-NSC
participates in outreach activities to educate the general community about the
importance of aging research and promote the need for basic biology of aging research
in particular.
article_processing_charge: No
article_type: original
author:
- first_name: Gerald S.
full_name: Shadel, Gerald S.
last_name: Shadel
- first_name: Peter D.
full_name: Adams, Peter D.
last_name: Adams
- first_name: W. Travis
full_name: Berggren, W. Travis
last_name: Berggren
- first_name: Jolene K.
full_name: Diedrich, Jolene K.
last_name: Diedrich
- first_name: Kenneth E.
full_name: Diffenderfer, Kenneth E.
last_name: Diffenderfer
- first_name: Fred H.
full_name: Gage, Fred H.
last_name: Gage
- first_name: Nasun
full_name: Hah, Nasun
last_name: Hah
- first_name: Malene
full_name: Hansen, Malene
last_name: Hansen
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
- first_name: Anthony J. A.
full_name: Molina, Anthony J. A.
last_name: Molina
- first_name: Uri
full_name: Manor, Uri
last_name: Manor
- first_name: Kurt
full_name: Marek, Kurt
last_name: Marek
- first_name: David D.
full_name: O’Keefe, David D.
last_name: O’Keefe
- first_name: Antonio F. M.
full_name: Pinto, Antonio F. M.
last_name: Pinto
- first_name: Alessandra
full_name: Sacco, Alessandra
last_name: Sacco
- first_name: Tatyana O.
full_name: Sharpee, Tatyana O.
last_name: Sharpee
- first_name: Maxim N.
full_name: Shokriev, Maxim N.
last_name: Shokriev
- first_name: Stefania
full_name: Zambetti, Stefania
last_name: Zambetti
citation:
ama: 'Shadel GS, Adams PD, Berggren WT, et al. The San Diego Nathan Shock Center:
Tackling the heterogeneity of aging. GeroScience. 2021;43(5):2139-2148.
doi:10.1007/s11357-021-00426-x'
apa: 'Shadel, G. S., Adams, P. D., Berggren, W. T., Diedrich, J. K., Diffenderfer,
K. E., Gage, F. H., … Zambetti, S. (2021). The San Diego Nathan Shock Center:
Tackling the heterogeneity of aging. GeroScience. Springer Nature. https://doi.org/10.1007/s11357-021-00426-x'
chicago: 'Shadel, Gerald S., Peter D. Adams, W. Travis Berggren, Jolene K. Diedrich,
Kenneth E. Diffenderfer, Fred H. Gage, Nasun Hah, et al. “The San Diego Nathan
Shock Center: Tackling the Heterogeneity of Aging.” GeroScience. Springer
Nature, 2021. https://doi.org/10.1007/s11357-021-00426-x.'
ieee: 'G. S. Shadel et al., “The San Diego Nathan Shock Center: Tackling
the heterogeneity of aging,” GeroScience, vol. 43, no. 5. Springer Nature,
pp. 2139–2148, 2021.'
ista: 'Shadel GS, Adams PD, Berggren WT, Diedrich JK, Diffenderfer KE, Gage FH,
Hah N, Hansen M, Hetzer M, Molina AJA, Manor U, Marek K, O’Keefe DD, Pinto AFM,
Sacco A, Sharpee TO, Shokriev MN, Zambetti S. 2021. The San Diego Nathan Shock
Center: Tackling the heterogeneity of aging. GeroScience. 43(5), 2139–2148.'
mla: 'Shadel, Gerald S., et al. “The San Diego Nathan Shock Center: Tackling the
Heterogeneity of Aging.” GeroScience, vol. 43, no. 5, Springer Nature,
2021, pp. 2139–48, doi:10.1007/s11357-021-00426-x.'
short: G.S. Shadel, P.D. Adams, W.T. Berggren, J.K. Diedrich, K.E. Diffenderfer,
F.H. Gage, N. Hah, M. Hansen, M. Hetzer, A.J.A. Molina, U. Manor, K. Marek, D.D.
O’Keefe, A.F.M. Pinto, A. Sacco, T.O. Sharpee, M.N. Shokriev, S. Zambetti, GeroScience
43 (2021) 2139–2148.
date_created: 2022-04-07T07:43:25Z
date_published: 2021-10-01T00:00:00Z
date_updated: 2022-07-18T08:27:24Z
day: '01'
doi: 10.1007/s11357-021-00426-x
extern: '1'
external_id:
pmid:
- '34370163'
intvolume: ' 43'
issue: '5'
keyword:
- Geriatrics and Gerontology
- Aging
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599742/
month: '10'
oa: 1
oa_version: Published Version
page: 2139-2148
pmid: 1
publication: GeroScience
publication_identifier:
issn:
- 2509-2715
- 2509-2723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The San Diego Nathan Shock Center: Tackling the heterogeneity of aging'
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 43
year: '2021'
...