--- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '22295' abstract: - lang: eng text: 'Despite the functional diversity of over 100 causal genes1,2,3, phenotypic convergence across models may reveal common neurobiological processes in autism spectrum disorder (ASD). Here we profiled 251 samples from 11 monogenic mouse models of ASD using single-nucleus multi-omic sequencing across three developmental stages, both sexes and two brain regions. Despite genetic heterogeneity, ASD-linked mutations converged on perturbations of the radial glial cell lineage. These alterations reflect a transient developmental delay rather than lasting lineage misspecification and resolve by postnatal stages. Molecularly, the largest transcriptional differences emerged in neurons at early postnatal stages. These changes included downregulation of synaptic and ion channel-related genes, consistent with homeostatic adaptation or delayed maturation. Network analysis showed molecular convergence across models within each developmental stage, suggesting that diverse mutations linked to ASD impinge on common, stage-specific processes. Convergence becomes less pronounced by postnatal day 14, highlighting the dynamic nature of ASD-associated changes. Cross-genotype heterogeneity is superimposed on stage-specific effects. Electrophysiology corroborated this pattern: mutants generally showed altered neuronal excitability and synaptic properties with model-specific nuances. Our study also highlighted sex-specific gene expression alterations, with female mice often displaying larger effect sizes than male mice. Together, our findings provide a comprehensive view of developmental cellular and molecular dynamics across models of ASD.' acknowledged_ssus: - _id: Bio - _id: LifeSc acknowledgement: We thank F. Freeman, V. Voronin and M. Ladron de Guevara for technical assistance; A. Stichelberger and S. Liegenfeld for the management of our animal colony; M. Schunn, C. Gold and the Preclinical Facility team for technical assistance; C. Jansen and the Scientific Computing Facility for bioinformatics support and technical assistance; the Biomedical Sequencing Facility at CeMM for assistance with next-generation sequencing; and J. Lin and T. Krausgruber in the laboratory of C. Bock for support with flow cytometry; J. Kirchner for illustrating the multi-omics approach depicted in Fig. 1; and all members of the laboratory of G.N. for their support and discussions. This study was supported by the Scientific Service Units of ISTA through resources provided by the Imaging & Optics Facility and the Laboratory Support Facility. Bulk RNA-seq was performed by the Next Generation Sequencing Facility at Vienna BioCenter Core Facilities, member of the Vienna BioCenter. This work was supported by a European Research Council Consolidator Grant (PR1028ERC02), by SFARI (PR1028SIM02) and by the Austrian Science Fund (PE1028W1232 and PR1028FG1803) to G.N. Open access funding provided by Institute of Science and Technology (IST Austria). article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Lena A full_name: Schwarz, Lena A id: 29A8453C-F248-11E8-B48F-1D18A9856A87 last_name: Schwarz - first_name: Christoph full_name: Dotter, Christoph id: 4C66542E-F248-11E8-B48F-1D18A9856A87 last_name: Dotter orcid: 0000-0002-9033-9096 - first_name: Sergey full_name: Isaev, Sergey last_name: Isaev - first_name: Michela full_name: Lisi, Michela id: 39383c1b-d3eb-11ef-8d6c-c8cdf4e10c8c last_name: Lisi - first_name: Daniel full_name: Malzl, Daniel last_name: Malzl - first_name: Christoph full_name: Büschl, Christoph id: 2a8c054c-0913-11ee-9159-f8ef515809ed last_name: Büschl - first_name: Sabrina full_name: Ladstätter, Sabrina last_name: Ladstätter - first_name: Bárbara full_name: Oliveira, Bárbara id: 3B03AA1A-F248-11E8-B48F-1D18A9856A87 last_name: Oliveira - first_name: Matteo full_name: Barel, Matteo id: 8959927b-2236-11ed-bd6e-ea83d94ade0e last_name: Barel - first_name: Bernadette full_name: Basilico, Bernadette id: 36035796-5ACA-11E9-A75E-7AF2E5697425 last_name: Basilico orcid: 0000-0003-1843-3173 - first_name: Chaitanya full_name: Chintaluri, Chaitanya id: BA06AFEE-A4BA-11EA-AE5C-14673DDC885E last_name: Chintaluri orcid: 0000-0003-4252-1608 - first_name: Sarah full_name: Gorkiewicz, Sarah id: f141a35d-15a9-11ec-9fb2-fef6becc7b6f last_name: Gorkiewicz - first_name: Mohammad full_name: Goudarzi, Mohammad id: 3384113A-F248-11E8-B48F-1D18A9856A87 last_name: Goudarzi - first_name: Tereza full_name: Belinova, Tereza id: 0bf89b6a-d28b-11eb-8bd6-f43768e4d368 last_name: Belinova - first_name: Stephan full_name: Reichl, Stephan last_name: Reichl - first_name: Gintarė full_name: Sendžikaitė, Gintarė id: dd6d52f2-c50d-11eb-9548-bcf0ff82b344 last_name: Sendžikaitė - first_name: Satish full_name: Arcot Jayaram, Satish id: b0bbee33-09f7-11eb-909c-8b358058d28a last_name: Arcot Jayaram orcid: 0000-0002-2479-2669 - first_name: Peter full_name: Koppensteiner, Peter id: 3B8B25A8-F248-11E8-B48F-1D18A9856A87 last_name: Koppensteiner orcid: 0000-0002-3509-1948 - first_name: Christoph M full_name: Sommer, Christoph M id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87 last_name: Sommer orcid: 0000-0003-1216-9105 - first_name: Tim P full_name: Vogels, Tim P id: CB6FF8D2-008F-11EA-8E08-2637E6697425 last_name: Vogels orcid: 0000-0003-3295-6181 - first_name: Jörg full_name: Menche, Jörg last_name: Menche - first_name: Igor full_name: Adameyko, Igor last_name: Adameyko - first_name: Peter Vasili full_name: Kharchenko, Peter Vasili id: 0095641e-7eb7-11f1-8665-aec51a2ab5e0 last_name: Kharchenko - first_name: Christoph full_name: Bock, Christoph last_name: Bock - first_name: Gaia full_name: Novarino, Gaia id: 3E57A680-F248-11E8-B48F-1D18A9856A87 last_name: Novarino orcid: 0000-0002-7673-7178 citation: ama: Schwarz LA, Dotter C, Isaev S, et al. Cortical development dynamics across autism spectrum disorder mouse models. Nature. 2026. doi:10.1038/s41586-026-10679-1 apa: Schwarz, L. A., Dotter, C., Isaev, S., Lisi, M., Malzl, D., Büschl, C., … Novarino, G. (2026). Cortical development dynamics across autism spectrum disorder mouse models. Nature. Springer Nature. https://doi.org/10.1038/s41586-026-10679-1 chicago: Schwarz, Lena A, Christoph Dotter, Sergey Isaev, Michela Lisi, Daniel Malzl, Christoph Büschl, Sabrina Ladstätter, et al. “Cortical Development Dynamics across Autism Spectrum Disorder Mouse Models.” Nature. Springer Nature, 2026. https://doi.org/10.1038/s41586-026-10679-1. ieee: L. A. Schwarz et al., “Cortical development dynamics across autism spectrum disorder mouse models,” Nature. Springer Nature, 2026. ista: Schwarz LA, Dotter C, Isaev S, Lisi M, Malzl D, Büschl C, Ladstätter S, Oliveira B, Barel M, Basilico B, Chintaluri C, Gorkiewicz S, Goudarzi M, Belinova T, Reichl S, Sendžikaitė G, Arcot Jayaram S, Koppensteiner P, Sommer CM, Vogels TP, Menche J, Adameyko I, Kharchenko PV, Bock C, Novarino G. 2026. Cortical development dynamics across autism spectrum disorder mouse models. Nature. mla: Schwarz, Lena A., et al. “Cortical Development Dynamics across Autism Spectrum Disorder Mouse Models.” Nature, Springer Nature, 2026, doi:10.1038/s41586-026-10679-1. short: L.A. Schwarz, C. Dotter, S. Isaev, M. Lisi, D. Malzl, C. Büschl, S. Ladstätter, B. Oliveira, M. Barel, B. Basilico, C. Chintaluri, S. Gorkiewicz, M. Goudarzi, T. Belinova, S. Reichl, G. Sendžikaitė, S. Arcot Jayaram, P. Koppensteiner, C.M. Sommer, T.P. Vogels, J. Menche, I. Adameyko, P.V. Kharchenko, C. Bock, G. Novarino, Nature (2026). corr_author: '1' dataavailabilitystatement: Single-nucleus multiomics data are available from the Gene Expression Omnibus (GSE328363). The mm10 reference genome was used for the alignment (refdata-cellranger-arc-mm10-2020-A-2.0.0, obtained from https://cf.10xgenomics.com/supp/cell-arc/refdata-cellranger-arc-mm10-2020-A-2.0.0.tar.gz). Single-cell data can be accessed and visualized through a CELLxGENE database (https://adameykolab.hifo.meduniwien.ac.at/cellxgene_public/filecrawl/.2026_Nature_Schwarz). Source data are provided with this paper. Scripts and analyses that support the main findings of this study are accessible in a GitHub repository (https://git.ista.ac.at/research-sofware/mouseome). date_created: 2026-07-13T09:47:21Z date_published: 2026-06-17T00:00:00Z date_updated: 2026-08-04T09:29:55Z day: '17' ddc: - '570' department: - _id: AnKi - _id: GaNo - _id: TiVo - _id: ScienComp - _id: GradSch - _id: Bio - _id: PreCl doi: 10.1038/s41586-026-10679-1 external_id: pmid: - '42310454' fulldoi: https://doi.org/10.1038/s41586-026-10679-1 has_accepted_license: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1038/s41586-026-10679-1 month: '06' oa: 1 oa_version: Published Version pmid: 1 project: - _id: 34ba8964-11ca-11ed-8bc3-e15864e7e9a6 grant_number: '101044865' name: Toward an understanding of the brain interstitial system and the extracellular proteome in health and autism spectrum disorders - _id: 9B91375C-BA93-11EA-9121-9846C619BF3A grant_number: '707964' name: Critical windows and reversibility of ASD associated with mutations in chromatin remodelers - _id: 2548AE96-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: W1232 name: Molecular Drug Targets - _id: ebb38b5d-77a9-11ec-83b8-a42e08120a88 grant_number: FG1803 49015 name: Neurobiology of anxiety in autism spectrum disorders publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: epub_ahead publisher: Springer Nature quality_controlled: '1' related_material: link: - description: News on ISTA website relation: press_release url: https://ista.ac.at/en/news/patterns-in-genetic-chaos/ researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: yes title: Cortical development dynamics across autism spectrum disorder mouse models tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2026' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '22268' abstract: - lang: eng text: AlphaFold3 predicts highly accurate protein structures from sequence but tends to collapse to a single dominant conformation, even when the underlying structure is inherently heterogeneous. Moreover, its predictions are oblivious to experimental conditions that can alter local sequence conformation. In this work, we show that AlphaFold3 can be guided to match data obtained by nuclear magnetic resonance (NMR) spectroscopy, X-ray crystallography and cryogenic electron microscopy (cryo-EM) experiments and combinations thereof. Our approach can also incorporate data that explicitly report on dynamics, such as site-resolved order parameters. We demonstrate that this methodology generates compact structural ensembles whose ensemble-averaged observables agree with experiment, with fewer distance restraint violations than traditionally resolved NMR structures and with unmodeled alternate conformations uncovered in electron density. This methodology paves the way for experimentally aware predictive models that generate structural ensembles consistent with the measurements, potentially over multiple modalities, and that can be further refined toward thermodynamically grounded ensembles by incorporating energetics. acknowledgement: A. Marx acknowledges the financial support of the Helmsley Fellowships Program for Sustainability and Health. A.M.B. and P.S. are supported by the Institute of Science and Technology Austria Internal Project Call grant Generative Protein NMR. S.V. was supported in part by funding from the Eric and Wendy Schmidt Center at the Broad Institute of MIT and Harvard. Open access funding provided by Institute of Science and Technology (IST Austria). article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Sai A full_name: Maddipatla, Sai A id: e957f5e5-91c9-11f0-a95f-e090f66ecb4d last_name: Maddipatla - first_name: Nadav E full_name: Sellam, Nadav E id: ef280fe0-91c9-11f0-a95f-8dea3f5bc513 last_name: Sellam - first_name: Meital I full_name: Bojan, Meital I id: 11d88cf5-91ca-11f0-a95f-edf9f08f47b7 last_name: Bojan - first_name: Vova full_name: Masalitin, Vova id: ff7958eb-91c9-11f0-a95f-f3bf65828cf6 last_name: Masalitin - first_name: Sanketh full_name: Vedula, Sanketh last_name: Vedula - first_name: Paul full_name: Schanda, Paul id: 7B541462-FAF6-11E9-A490-E8DFE5697425 last_name: Schanda orcid: 0000-0002-9350-7606 - first_name: Ailie full_name: Marx, Ailie last_name: Marx - first_name: Alexander full_name: Bronstein, Alexander id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6 last_name: Bronstein orcid: 0000-0001-9699-8730 citation: ama: Maddipatla SA, Sellam NE, Bojan MI, et al. Experiment-guided AlphaFold3 resolves measurement-consistent protein ensembles. Nature Biotechnology. 2026. doi:10.1038/s41587-026-03166-5 apa: Maddipatla, S. A., Sellam, N. E., Bojan, M. I., Masalitin, V., Vedula, S., Schanda, P., … Bronstein, A. M. (2026). Experiment-guided AlphaFold3 resolves measurement-consistent protein ensembles. Nature Biotechnology. Springer Nature. https://doi.org/10.1038/s41587-026-03166-5 chicago: Maddipatla, Sai A, Nadav E Sellam, Meital I Bojan, Vova Masalitin, Sanketh Vedula, Paul Schanda, Ailie Marx, and Alex M. Bronstein. “Experiment-Guided AlphaFold3 Resolves Measurement-Consistent Protein Ensembles.” Nature Biotechnology. Springer Nature, 2026. https://doi.org/10.1038/s41587-026-03166-5. ieee: S. A. Maddipatla et al., “Experiment-guided AlphaFold3 resolves measurement-consistent protein ensembles,” Nature Biotechnology. Springer Nature, 2026. ista: Maddipatla SA, Sellam NE, Bojan MI, Masalitin V, Vedula S, Schanda P, Marx A, Bronstein AM. 2026. Experiment-guided AlphaFold3 resolves measurement-consistent protein ensembles. Nature Biotechnology. mla: Maddipatla, Sai A., et al. “Experiment-Guided AlphaFold3 Resolves Measurement-Consistent Protein Ensembles.” Nature Biotechnology, Springer Nature, 2026, doi:10.1038/s41587-026-03166-5. short: S.A. Maddipatla, N.E. Sellam, M.I. Bojan, V. Masalitin, S. Vedula, P. Schanda, A. Marx, A.M. Bronstein, Nature Biotechnology (2026). corr_author: '1' das_tickbox: '1' dataavailabilitystatement: All structures and metrics reported in this paper are openly available on Harvard Dataverse - https://doi.org/10.7910/DVN/PLYUHN. All code is openly available on GitHub (https://github.com/sai-advaith/guided_alphafold); the version used for this paper (version 0.9.1) is permanently archived on Zenodo https://doi.org/10.5281/zenodo.17307005 date_created: 2026-07-12T22:02:19Z date_published: 2026-06-29T00:00:00Z date_updated: 2026-08-04T09:25:18Z day: '29' ddc: - '570' department: - _id: PaSc - _id: AlBr - _id: GradSch doi: 10.1038/s41587-026-03166-5 external_id: pmid: - '42374114' fulldoi: https://doi.org/10.1038/s41587-026-03166-5 has_accepted_license: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1038/s41587-026-03166-5 month: '06' oa: 1 oa_version: Published Version pmid: 1 publication: Nature Biotechnology publication_identifier: eissn: - 1546-1696 issn: - 1087-0156 publication_status: epub_ahead publisher: Springer Nature quality_controlled: '1' related_material: link: - description: News on ISTA website relation: press_release url: https://ista.ac.at/en/news/toward-experiment-guided-alphafold/ researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: yes title: Experiment-guided AlphaFold3 resolves measurement-consistent protein ensembles tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '21987' abstract: - lang: eng text: 'We introduce JODIE, a genetic joint modeling approach that estimates how DNA loci influence human traits by partitioning genetic effects into four components: direct effects (from a child’s alleles), indirect maternal and paternal effects (from parents’ alleles), and parent-of-origin (PofO) effects (dependent on parental transmission of alleles), while uniquely accounting for assortative mating. We analyze 30,000 child-mother-father trios from the Estonian Biobank and the Norwegian Mother, Father, and Child Cohort, focusing on height, body mass index, and childhood educational test scores. We find direct effects to be the largest contributor to trait variation, but combined, indirect parental and PofO effects are similarly substantial. We support our results by within-family genome-wide association testing and identify 276 independently associated DNA regions with a complex interplay between direct, indirect, and PofO effects. By joint modeling, we show that direct, indirect, and PofO effects collectively shape human phenotypic variation across loci genome-wide.' acknowledged_ssus: - _id: ScienComp acknowledgement: "We thank Zoltan Kutalik, Peter Visscher, and members of the Robinson group at ISTA for their comments, which improved this manuscript. This work was funded by an SNSF Eccellenza Grant to M.R.R. (PCEGP3-181181) and by core funding from the Institute of Science and Technology Austria.\r\nThe Norwegian Mother, Father, and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research. We are grateful to all the participating families in Norway who take part in this on-going cohort study. We thank the Norwegian Institute of Public Health (NIPH) for generating high-quality genomic data. The research is part of the HARVEST collaboration, supported by the Research Council of Norway (#229624). We also thank the NORMENT Center for providing genotype data, funded by the Research Council of Norway (#223273), South East Norway Health Authorities, and Stiftelsen Kristian Gerhard Jebsen, and in collaboration with deCODE Genetics. We further thank the Center for Diabetes Research, the University of Bergen for providing genotype data funded by the ERC AdG project SELECTionPREDISPOSED, Stiftelsen Kristian Gerhard Jebsen, Trond Mohn Foundation, the Research Council of Norway, the Novo Nordisk Foundation, the University of Bergen, and the Western Norway Health Authorities. The MoBa work was performed on the TSD (Tjeneste for Sensitive Data) facilities, owned by the University of Oslo, operated and developed by the TSD service group at the University of Oslo, IT Department (USIT, tsd-drift@usit.uio.no). E.Y. is supported by the European Union (grant numbers 101045526 and 101073237) and the Research Council of Norway (grant numbers 336078, 288083, and 331640).\r\nWe would like to acknowledge the participants and investigators of the Generation Scotland Cohort study. Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates (CZD/16/6) and the Scottish Funding Council (HR03006). Genotyping and methylation typing of the GS:SFHS samples was carried out by the Genetics Core Laboratory at the Wellcome Trust Clinical Research Facility, Edinburgh, Scotland and was funded by the Medical Research Council UK and the Wellcome Trust (Wellcome Trust Strategic Award “STratifying Resilience and Depression Longitudinally” [STRADL] ref. 104036/Z/14/Z).\r\nWe would like to thank and acknowledge the participants and investigators of the Estonian Biobank (EstBB) study. The research was conducted using the Estonian Center of Genomics/Roadmap II funded by the Estonian Research Council (project number TT17).\r\nNorwegian analyses were performed on resources provided by Sigma2 - the National Infrastructure for High-Performance Computing and Data Storage in Norway. Estonian Data analysis was carried out in the High-Performance Computing Center cloud provided by University of Tartu. Analysis of the Generation Scotland data and the summary statistics obtained from the other analyses was conducted at IST Austria and is supported by the Scientific Service Units (SSU) of IST Austria through resources provided by Scientific Computing (SciComp)." article_number: '101277' article_processing_charge: Yes article_type: original author: - first_name: Ilse full_name: Krätschmer, Ilse id: 30d4014e-7753-11eb-b44b-db6d61112e73 last_name: Krätschmer orcid: 0000-0002-5636-9259 - first_name: Laura full_name: Hegemann, Laura last_name: Hegemann - first_name: Robin J. full_name: Hofmeister, Robin J. last_name: Hofmeister - first_name: Elizabeth C. full_name: Corfield, Elizabeth C. last_name: Corfield - first_name: Mahdi full_name: Mahmoudi, Mahdi last_name: Mahmoudi - first_name: Olivier full_name: Delaneau, Olivier last_name: Delaneau - first_name: Ole A. full_name: Andreassen, Ole A. last_name: Andreassen - first_name: Archie full_name: Campbell, Archie last_name: Campbell - first_name: Caroline full_name: Hayward, Caroline last_name: Hayward - first_name: Riccardo E. full_name: Marioni, Riccardo E. last_name: Marioni - first_name: Eivind full_name: Ystrom, Eivind last_name: Ystrom - first_name: Alexandra full_name: Havdahl, Alexandra last_name: Havdahl - first_name: Matthew Richard full_name: Robinson, Matthew Richard id: E5D42276-F5DA-11E9-8E24-6303E6697425 last_name: Robinson orcid: 0000-0001-8982-8813 citation: ama: Krätschmer I, Hegemann L, Hofmeister RJ, et al. Separating direct, indirect, and parent-of-origin genetic effects in the human population. Cell Genomics. 2026;6(7). doi:10.1016/j.xgen.2026.101277 apa: Krätschmer, I., Hegemann, L., Hofmeister, R. J., Corfield, E. C., Mahmoudi, M., Delaneau, O., … Robinson, M. R. (2026). Separating direct, indirect, and parent-of-origin genetic effects in the human population. Cell Genomics. Elsevier. https://doi.org/10.1016/j.xgen.2026.101277 chicago: Krätschmer, Ilse, Laura Hegemann, Robin J. Hofmeister, Elizabeth C. Corfield, Mahdi Mahmoudi, Olivier Delaneau, Ole A. Andreassen, et al. “Separating Direct, Indirect, and Parent-of-Origin Genetic Effects in the Human Population.” Cell Genomics. Elsevier, 2026. https://doi.org/10.1016/j.xgen.2026.101277. ieee: I. Krätschmer et al., “Separating direct, indirect, and parent-of-origin genetic effects in the human population,” Cell Genomics, vol. 6, no. 7. Elsevier, 2026. ista: Krätschmer I, Hegemann L, Hofmeister RJ, Corfield EC, Mahmoudi M, Delaneau O, Andreassen OA, Campbell A, Hayward C, Marioni RE, Ystrom E, Havdahl A, Robinson MR. 2026. Separating direct, indirect, and parent-of-origin genetic effects in the human population. Cell Genomics. 6(7), 101277. mla: Krätschmer, Ilse, et al. “Separating Direct, Indirect, and Parent-of-Origin Genetic Effects in the Human Population.” Cell Genomics, vol. 6, no. 7, 101277, Elsevier, 2026, doi:10.1016/j.xgen.2026.101277. short: I. Krätschmer, L. Hegemann, R.J. Hofmeister, E.C. Corfield, M. Mahmoudi, O. Delaneau, O.A. Andreassen, A. Campbell, C. Hayward, R.E. Marioni, E. Ystrom, A. Havdahl, M.R. Robinson, Cell Genomics 6 (2026). corr_author: '1' das_tickbox: '1' dataavailabilitystatement: "Information on how to access the MoBaPsychGen post-imputation QC data are available here: https://www.fhi.no/en/me/the-psychgen-centre-for-genetic-epidemiology-and-mental-health/access-to-genetic-data-after-quality-control-by-the-mobapsychgen-pipeline-v/.\r\nEstonian Biobank data (https://genomics.ut.ee/en/content/estonian-biobank) were used in this project. For access to be granted to the Estonian Biobank genotypic and corresponding phenotypic data, a preliminary application must be presented to the oversight committee, who must first approve the project. Ethics permission must then be obtained from the Estonian Committee on Bioethics and Human Research. Finally, a full project must be submitted and approved by the Estonian Biobank.\r\nAccess to the Generation Scotland data is available with appropriate permission from the Generation Scotland Access Committee. Applications should be made to access@generationscotland.org (https://genscot.ed.ac.uk/).\r\nThe code for JODIE developed in this work is open source and is publicly available on zenodo (https://doi.org/10.5281/zenodo.19593928) and GitHub (https://github.com/medical-genomics-group/JODIE).\r\nHaplotype Reference Consortium Release 1.1 data (https://ega-archive.org/datasets/EGAD00001002729) are available by application to a Data Access Committee (DAC) of the Wellcome Trust Sanger Institute.\r\nThe Common Metabolic Diseases Atlas can be accessed here: https://cmdga.org." date_created: 2026-06-10T07:39:08Z date_published: 2026-07-08T00:00:00Z date_updated: 2026-08-04T09:34:08Z day: '08' ddc: - '570' department: - _id: MaRo doi: 10.1016/j.xgen.2026.101277 external_id: pmid: - '40909755' file: - access_level: open_access checksum: f896b510480d2d4e4a7fd46c2e2761f4 content_type: application/pdf creator: dernst date_created: 2026-07-28T07:24:50Z date_updated: 2026-07-28T07:24:50Z file_id: '22597' file_name: 2026_CellGenomics_Kraetschmer.pdf file_size: 3679297 relation: main_file success: 1 file_date_updated: 2026-07-28T07:24:50Z fulldoi: https://doi.org/10.1016/j.xgen.2026.101277 has_accepted_license: '1' intvolume: ' 6' issue: '7' keyword: - direct genetic effects - DGE - indirect genetic effects - IGE - parent-of-origin effects - phenotypic variation - assortative mating - within-family GWAS - MoBa - EstBB language: - iso: eng month: '07' oa: 1 oa_version: Published Version pmid: 1 project: - _id: 9B8D11D6-BA93-11EA-9121-9846C619BF3A grant_number: PCEGP3_181181 name: Improving estimation and prediction of common complex disease risk publication: Cell Genomics publication_identifier: eissn: - 2666-979X publication_status: published publisher: Elsevier quality_controlled: '1' related_material: link: - description: News on ISTA website relation: press_release url: https://ista.ac.at/en/news/human-traits-beyond-inherited-genes/ researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: yes title: Separating direct, indirect, and parent-of-origin genetic effects in the human population tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 6 year: '2026' ... --- OA_place: publisher _id: '22334' abstract: - lang: eng text: "Characterizing protein dynamics at the atomic level is essential for our understanding of biological mechanisms. Whether it is to facilitate metabolite transport, catalyze reactions, transmit signals, or regulate metabolism – proteins are constantly in motion and sample multiple conformational states to fulfill their function. Nuclear magnetic resonance (NMR) spectroscopy is particularly well suited to elucidate the dynamics of biomolecules on their complex free-energy landscape. In particular, solid-state magic-angle spinning (MAS) NMR enables the study of large molecular assemblies, protein crystals, or insoluble proteins at atomic resolution without an inherent molecular size limitation. MAS NMR experiments to probe protein dynamics are extremely versatile and sensitive to motional timescales from picoseconds to seconds. Over the past decades, technological advances, developments in experimental design, and new isotope-labeling approaches have further expanded the possibilities of this technique and significantly improved the accuracy of the determined motional parameters.\r\nFunctionally important sites of proteins often contain aromatic residues. Their side-chain motions have therefore long served as valuable indicators of mechanistically relevant dynamics in NMR studies. In this thesis, site-specifically labeled aromatic residues act as sensitive reporters for MAS NMR studies of protein dynamics. The first part addresses how different environments impact side-chain motion by probing ring flips of phenylalanines and tyrosines in crystalline proteins and amyloid fibrils. It provides important insights for the analysis of dynamics obtained in non-native protein environments and emphasizes the complex factors that determine the timescale of internal dynamics. In the second part, the focus shifts towards methodological questions regarding the investigation of protein dynamics by 19F MAS NMR. The fluorine nucleus exhibits promising characteristics for NMR studies but also presents significant challenges, which is why the full methodological potential of 19F MAS NMR has not been fully realized yet. This work demonstrates that paramagnetic doping can considerably reduce the measurement time and improve the sensitivity of fluorinated samples. Finally, 19F MAS NMR is evaluated as a tool for studying protein side-chain dynamics on the example of tryptophans. The results illustrate the challenges in analyzing such experiments and lay the foundation for further development of 19F MAS NMR relaxation studies.\r\nTaken together, this thesis highlights the potential of combining specific isotope labeling, MAS NMR, and complementary methods such as crystallography and computational simulations to elucidate internal protein dynamics. The further development of such integrative approaches will be crucial to improving our understanding of complex mechanisms and protein function.\r\n" acknowledged_ssus: - _id: LifeSc - _id: NMR acknowledgement: "During the work on this thesis, I was the recipient of a DOC Fellowship of the Austrian\r\nAcademy of Sciences at the Institute of Science and Technology Austria (grant no. PR10660EAW01)." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Lea Marie full_name: Becker, Lea Marie id: 36336939-eb97-11eb-a6c2-c83f1214ca79 last_name: Becker orcid: 0000-0002-6401-5151 citation: ama: Becker LM. Exploring protein dynamics using specific labeling approaches for solid-state MAS NMR. 2026. doi:10.15479/AT-ISTA-22334 apa: Becker, L. M. (2026). Exploring protein dynamics using specific labeling approaches for solid-state MAS NMR. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-22334 chicago: Becker, Lea Marie. “Exploring Protein Dynamics Using Specific Labeling Approaches for Solid-State MAS NMR.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-22334. ieee: L. M. Becker, “Exploring protein dynamics using specific labeling approaches for solid-state MAS NMR,” Institute of Science and Technology Austria, 2026. ista: Becker LM. 2026. Exploring protein dynamics using specific labeling approaches for solid-state MAS NMR. Institute of Science and Technology Austria. mla: Becker, Lea Marie. Exploring Protein Dynamics Using Specific Labeling Approaches for Solid-State MAS NMR. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-22334. short: L.M. Becker, Exploring Protein Dynamics Using Specific Labeling Approaches for Solid-State MAS NMR, Institute of Science and Technology Austria, 2026. corr_author: '1' das_tickbox: '1' date_created: 2026-07-14T08:08:51Z date_published: 2026-07-13T00:00:00Z date_updated: 2026-08-04T09:32:45Z day: '13' ddc: - '572' degree_awarded: PhD department: - _id: GradSch - _id: PaSc doi: 10.15479/AT-ISTA-22334 doi_confirm: '1' file: - access_level: closed checksum: 8b85114eff543916c0e1445cd2189555 content_type: application/zip creator: lbecker date_created: 2026-07-16T09:17:08Z date_updated: 2026-07-16T09:17:08Z file_id: '22346' file_name: 2026_Becker_Lea_source_files.zip file_size: 99472908 relation: source_file - access_level: open_access checksum: 6c526862bc6dbd1e4c80ecb34580bc58 content_type: application/pdf creator: lbecker date_created: 2026-07-16T09:17:05Z date_updated: 2026-07-16T09:17:05Z file_id: '22347' file_name: 2026_Becker_Lea_Thesis.pdf file_size: 74647289 relation: main_file success: 1 file_date_updated: 2026-07-16T09:17:08Z fulldoi: https://doi.org/10.15479/AT-ISTA-22334 has_accepted_license: '1' language: - iso: eng month: '07' oa: 1 oa_version: Published Version page: '205' project: - _id: 7be609c4-9f16-11ee-852c-85015ce2b9b0 grant_number: '26777' name: Exploring protein dynamics by solid-state MAS NMR through specific labeling approaches publication_identifier: isbn: - 978-3-99078-084-8 issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '12675' relation: part_of_dissertation status: public - id: '21777' relation: part_of_dissertation status: public - id: '12114' relation: part_of_dissertation status: public - id: '22105' relation: part_of_dissertation status: public status: public supervisor: - first_name: Paul full_name: Schanda, Paul id: 7B541462-FAF6-11E9-A490-E8DFE5697425 last_name: Schanda orcid: 0000-0002-9350-7606 title: Exploring protein dynamics using specific labeling approaches for solid-state MAS NMR tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: dissertation user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2026' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '22105' abstract: - lang: eng text: Protein conformational energy landscapes are shaped not only by intramolecular interactions but also by their environment. In protein crystals and protein–protein complexes, intermolecular contacts alter this energy landscape, but the exact nature of this alteration is difficult to decipher. Understanding how the crystal lattice affects protein dynamics is crucial for crystallography-based studies of motion, yet its influence on collective motions remains unclear. Aromatic ring flips in the hydrophobic core represent sensitive probes of such dynamics. Here, we compare the kinetics of aromatic ring flips in the protein GB1 in crystals, in complex with its binding partner IgG, and in solution, combining advanced isotope labelling with quantitative NMR methods. We show that rings in the core flip nearly a thousand times less frequently in crystals than in solution. Enhanced-sampling molecular dynamics simulations, based on a crystal structure of a GB1 variant reported in this work, reproduce these elevated barriers and reveal how the crystal restrains motions. acknowledged_ssus: - _id: NMR - _id: LifeSc acknowledgement: We thank N. R. Skrynnikov and O. O. Lebedenko (St. Petersburg) for insightful discussions and for performing exploratory MD simulations. We are grateful to T. Schubeis (Lyon) for advice on GB1 crystallization and R. Schmid for initial crystallization trials. We thank C. Mueller-Dieckmann for assistance with room-temperature X-ray crystallography data collection on beamline ID30B at the ESRF, which is acknowledged for providing beamtime through its In-House Research programme. We thank S. Falkner for assistance with constructing the structural model of the IgG:GB1 complex. We thank J. Lewandowski for providing feedback on the paper and granting access to backbone relaxation data of IgG:GB1T2Q and GB1T2Q microcrystals. This research was supported by the Scientific Service Units (SSU) of the Institute of Science and Technology Austria (ISTA) through resources provided by the Nuclear Magnetic Resonance and the Lab Support Facilities. We thank P. Rovó and M. V. Falcón for excellent support of the NMR facility. L.M.B. is recipient of a DOC fellowship of the Austrian Academy of Sciences at the Institute of Science and Technology Austria (grant number PR10660EAW01). C.C. acknowledges the European Research Council (grant project 101097272 ‘MilliInMicro’) and the Métropole du Grand Nancy (grant project ‘ARC’). BM07-FIP2 is supported by the French ANR PIA3 (France 2030) EquipEx+ project MAGNIFIX under grant agreement ANR-21-ESRE-0011.Open access funding provided by Institute of Science and Technology (IST Austria). article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Lea Marie full_name: Becker, Lea Marie id: 36336939-eb97-11eb-a6c2-c83f1214ca79 last_name: Becker orcid: 0000-0002-6401-5151 - first_name: Haohao full_name: Fu, Haohao last_name: Fu - first_name: Benjamin full_name: Tatman, Benjamin id: 71cda2f3-e604-11ee-a1df-da10587eda3f last_name: Tatman - first_name: Matthias full_name: Dreydoppel, Matthias last_name: Dreydoppel - first_name: Anna full_name: Kapitonova, Anna id: 9fb2a840-89e1-11ee-a8b7-cc5c7ba62471 last_name: Kapitonova - first_name: Daniel full_name: Balazs, Daniel id: 302BADF6-85FC-11EA-9E3B-B9493DDC885E last_name: Balazs orcid: 0000-0001-7597-043X - first_name: Ulrich full_name: Weininger, Ulrich last_name: Weininger - first_name: Sylvain full_name: Engilberge, Sylvain last_name: Engilberge - first_name: Christophe full_name: Chipot, Christophe last_name: Chipot - first_name: Paul full_name: Schanda, Paul id: 7B541462-FAF6-11E9-A490-E8DFE5697425 last_name: Schanda orcid: 0000-0002-9350-7606 citation: ama: Becker LM, Fu H, Tatman B, et al. Aromatic ring flips reveal reshaping of protein dynamics in crystals and complexes. Nature Chemistry. 2026;18:1221-1230. doi:10.1038/s41557-026-02155-0 apa: Becker, L. M., Fu, H., Tatman, B., Dreydoppel, M., Kapitonova, A., Balazs, D., … Schanda, P. (2026). Aromatic ring flips reveal reshaping of protein dynamics in crystals and complexes. Nature Chemistry. Springer Nature. https://doi.org/10.1038/s41557-026-02155-0 chicago: Becker, Lea Marie, Haohao Fu, Benjamin Tatman, Matthias Dreydoppel, Anna Kapitonova, Daniel Balazs, Ulrich Weininger, Sylvain Engilberge, Christophe Chipot, and Paul Schanda. “Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.” Nature Chemistry. Springer Nature, 2026. https://doi.org/10.1038/s41557-026-02155-0. ieee: L. M. Becker et al., “Aromatic ring flips reveal reshaping of protein dynamics in crystals and complexes,” Nature Chemistry, vol. 18. Springer Nature, pp. 1221–1230, 2026. ista: Becker LM, Fu H, Tatman B, Dreydoppel M, Kapitonova A, Balazs D, Weininger U, Engilberge S, Chipot C, Schanda P. 2026. Aromatic ring flips reveal reshaping of protein dynamics in crystals and complexes. Nature Chemistry. 18, 1221–1230. mla: Becker, Lea Marie, et al. “Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.” Nature Chemistry, vol. 18, Springer Nature, 2026, pp. 1221–30, doi:10.1038/s41557-026-02155-0. short: L.M. Becker, H. Fu, B. Tatman, M. Dreydoppel, A. Kapitonova, D. Balazs, U. Weininger, S. Engilberge, C. Chipot, P. Schanda, Nature Chemistry 18 (2026) 1221–1230. corr_author: '1' das_tickbox: '1' dataavailabilitystatement: The cryo and room-temperature crystal structures of GB1QDD are deposited at the PDB under the access codes 9I2I and 9T8Z, respectively. The solid-state NMR backbone assignment of GB1QDD is deposited at the BMRB under the access code 53330. NMR spectra, analysis scripts and raw data are publicly available at the ISTA research explorer (https://doi.org/10.15479/AT-ISTA-20641)120. Files to reproduce the enhanced-sampling MD simulations are publicly available at the ISTA research explorer (https://doi.org/10.15479/AT-ISTA-21145)121. date_created: 2026-06-21T22:03:01Z date_published: 2026-07-01T00:00:00Z date_updated: 2026-08-04T09:32:45Z day: '01' ddc: - '540' department: - _id: PaSc - _id: LifeSc doi: 10.1038/s41557-026-02155-0 external_id: pmid: - '42271006' file: - access_level: open_access checksum: 1069fb27949fd2cb641b043b3a96a580 content_type: application/pdf creator: dernst date_created: 2026-07-28T06:58:35Z date_updated: 2026-07-28T06:58:35Z file_id: '22595' file_name: 2026_NatureChemistry_Becker.pdf file_size: 2618184 relation: main_file success: 1 file_date_updated: 2026-07-28T06:58:35Z fulldoi: https://doi.org/10.1038/s41557-026-02155-0 has_accepted_license: '1' intvolume: ' 18' language: - iso: eng month: '07' oa: 1 oa_version: Published Version page: 1221-1230 pmid: 1 project: - _id: 7be609c4-9f16-11ee-852c-85015ce2b9b0 grant_number: '26777' name: Exploring protein dynamics by solid-state MAS NMR through specific labeling approaches publication: Nature Chemistry publication_identifier: eissn: - '17554349' issn: - '17554330' publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: link: - description: News on ISTA website relation: research_data url: https://ista.ac.at/en/news/how-proteins-breathe/ record: - id: '20641' relation: research_data status: public - id: '21145' relation: research_data status: public - id: '22334' relation: dissertation_contains status: public researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: yes title: Aromatic ring flips reveal reshaping of protein dynamics in crystals and complexes tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 18 year: '2026' ... --- _id: '21145' abstract: - lang: eng text: 'Protein conformational energy landscapes are shaped not only by intramolecular interactions but also by their environment. In protein crystals and protein-protein complexes, intermolecular contacts alter this energy landscape, but the exact nature of this alteration is difficult to decipher. Understanding how the crystal lattice affects protein dynamics is crucial for crystallography-based studies of motion, yet its influence on collective motions remains unclear. Aromatic ring flips in the hydrophobic core represent sensitive probes of such dynamics. Here, we compare the kinetics of aromatic ring flips in the protein GB1 in crystals, in complex with its binding partner IgG, and in solution, combining advanced isotope labeling with quantitative NMR methods. We show that rings in the core flip nearly a thousand times less frequently in crystals than in solution. Enhanced-sampling molecular dynamics simulations, based on a new crystal structure, reproduce these elevated barriers and reveal how the crystal restrains motions. ' acknowledged_ssus: - _id: NMR - _id: LifeSc acknowledgement: "We thank Nikolai R. Skrynnikov and Olga O. Lebedenko (St. Petersburg) for insightful discussions and for performing exploratory MD simulations. We are grateful to Tobias Schubeis (Lyon) for advice with GB1 crystallization, and Rebecca Schmid for initial crystallization trials.\r\nWe thank Sebastian Falkner for assistance with constructing the structural model of the IgG:GB1 complex.\r\nThis research was supported by the Scientific Service Units (SSU) of Institute of Science and Technology Austria (ISTA) through resources provided by the Nuclear Magnetic Resonance and the Lab Support Facilities. We thank Petra Rovó and Margarita Valhondo Falcón for excellent support of the NMR facility.\r\nLea M. Becker is recipient of a DOC fellowship of the Austrian Academy of Sciences at the Institute of Science and Technology Austria (grant no. PR10660EAW01). Christophe Chipot acknowledges the European Research Council (grant project 101097272 ``MilliInMicro'') and the Métropole du Grand Nancy (grant project ``ARC''). BM07-FIP2 is supported by the French ANR PIA3 (France 2030) EquipEx+ project MAGNIFIX under grant agreement ANR-21-ESRE-0011." article_processing_charge: No author: - first_name: Lea Marie full_name: Becker, Lea Marie id: 36336939-eb97-11eb-a6c2-c83f1214ca79 last_name: Becker orcid: 0000-0002-6401-5151 - first_name: Paul full_name: Schanda, Paul id: 7B541462-FAF6-11E9-A490-E8DFE5697425 last_name: Schanda orcid: 0000-0002-9350-7606 - first_name: Christophe full_name: Chipot, Christophe last_name: Chipot citation: ama: Becker LM, Schanda P, Chipot C. Additional Data for “Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.” 2026. doi:10.15479/AT-ISTA-21145 apa: Becker, L. M., Schanda, P., & Chipot, C. (2026). Additional Data for “Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21145 chicago: Becker, Lea Marie, Paul Schanda, and Christophe Chipot. “Additional Data for ‘Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.’” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21145. ieee: L. M. Becker, P. Schanda, and C. Chipot, “Additional Data for ‘Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.’” Institute of Science and Technology Austria, 2026. ista: Becker LM, Schanda P, Chipot C. 2026. Additional Data for ‘Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes’, Institute of Science and Technology Austria, 10.15479/AT-ISTA-21145. mla: Becker, Lea Marie, et al. Additional Data for “Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.” Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21145. short: L.M. Becker, P. Schanda, C. Chipot, (2026). contributor: - contributor_type: researcher first_name: Haohao last_name: Fu - contributor_type: researcher first_name: Benjamin id: 71cda2f3-e604-11ee-a1df-da10587eda3f last_name: Tatman - contributor_type: researcher first_name: Matthias last_name: Dreydoppel - contributor_type: researcher first_name: Anna id: 9fb2a840-89e1-11ee-a8b7-cc5c7ba62471 last_name: Kapitonova - contributor_type: researcher first_name: Daniel id: 302BADF6-85FC-11EA-9E3B-B9493DDC885E last_name: Balazs orcid: 0000-0001-7597-043X - contributor_type: researcher first_name: Ulrich last_name: Weininger - contributor_type: researcher first_name: Sylvain last_name: Engilberge corr_author: '1' date_created: 2026-02-05T13:54:39Z date_published: 2026-02-09T00:00:00Z date_updated: 2026-08-04T09:32:45Z day: '09' ddc: - '572' department: - _id: GradSch - _id: PaSc doi: 10.15479/AT-ISTA-21145 file: - access_level: open_access checksum: 02a419cce8cea450bc952f35488d2df5 content_type: text/plain creator: lbecker date_created: 2026-02-05T13:52:37Z date_updated: 2026-02-05T13:52:37Z file_id: '21146' file_name: README.txt file_size: 4263 relation: table_of_contents - access_level: open_access checksum: b0b82b1aa73985b0b308a3fa52d21aea content_type: application/zip creator: lbecker date_created: 2026-02-05T13:52:41Z date_updated: 2026-02-05T13:52:41Z file_id: '21147' file_name: Research_Data.zip file_size: 50647107 relation: main_file success: 1 file_date_updated: 2026-02-05T13:52:41Z fulldoi: https://doi.org/10.15479/AT-ISTA-21145 has_accepted_license: '1' license: https://creativecommons.org/licenses/by-nc/4.0/ month: '02' oa: 1 oa_version: Published Version project: - _id: 7be609c4-9f16-11ee-852c-85015ce2b9b0 grant_number: '26777' name: Exploring protein dynamics by solid-state MAS NMR through specific labeling approaches publisher: Institute of Science and Technology Austria related_material: record: - id: '20641' relation: earlier_version status: public - id: '22105' relation: used_in_publication status: public status: public title: Additional Data for "Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes" tmp: image: /images/cc_by_nc.png legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) short: CC BY-NC (4.0) type: research_data user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '22613' abstract: - lang: eng text: 'A phase plate has long been sought in transmission electron microscopy (TEM) to maximize the image contrast of weakly-scattering objects like biomolecules. The laser phase plate (LPP) has recently demonstrated that an amplified, focused laser standing wave reliably phase shifts the electron beam, achieving phase-contrast TEM. Building on the single-beam LPP, here we introduce the crossed laser phase plate (XLPP): two laser standing waves which intersect in the diffraction plane. We present a theoretical model for the XLPP inside the microscope and show that, relative to the original LPP, it increases information transfer at low spatial frequencies while suppressing ghost images formed by Kapitza-Dirac diffraction. We also present a simple acquisition scheme, enabled by the XLPP, which further suppresses ghosts. Finally, we discuss practical considerations of XLPP design and show experimental results from a prototype. The results of this study chart the course for future developments of LPP hardware.' article_number: '7199' article_processing_charge: Yes article_type: original author: - first_name: Petar N full_name: Petrov, Petar N id: b1d6732d-8cb6-11f0-baab-bd460ee3a287 last_name: Petrov - first_name: Jessie T. full_name: Zhang, Jessie T. last_name: Zhang - first_name: Jeremy J. full_name: Axelrod, Jeremy J. last_name: Axelrod - first_name: Pavel K. full_name: Olshin, Pavel K. last_name: Olshin - first_name: Holger full_name: Müller, Holger last_name: Müller citation: ama: Petrov PN, Zhang JT, Axelrod JJ, Olshin PK, Müller H. Crossed laser phase plates for transmission electron microscopy. Nature Communications. 2026;17. doi:10.1038/s41467-026-74060-6 apa: Petrov, P. N., Zhang, J. T., Axelrod, J. J., Olshin, P. K., & Müller, H. (2026). Crossed laser phase plates for transmission electron microscopy. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-026-74060-6 chicago: Petrov, Petar N, Jessie T. Zhang, Jeremy J. Axelrod, Pavel K. Olshin, and Holger Müller. “Crossed Laser Phase Plates for Transmission Electron Microscopy.” Nature Communications. Springer Nature, 2026. https://doi.org/10.1038/s41467-026-74060-6. ieee: P. N. Petrov, J. T. Zhang, J. J. Axelrod, P. K. Olshin, and H. Müller, “Crossed laser phase plates for transmission electron microscopy,” Nature Communications, vol. 17. Springer Nature, 2026. ista: Petrov PN, Zhang JT, Axelrod JJ, Olshin PK, Müller H. 2026. Crossed laser phase plates for transmission electron microscopy. Nature Communications. 17, 7199. mla: Petrov, Petar N., et al. “Crossed Laser Phase Plates for Transmission Electron Microscopy.” Nature Communications, vol. 17, 7199, Springer Nature, 2026, doi:10.1038/s41467-026-74060-6. short: P.N. Petrov, J.T. Zhang, J.J. Axelrod, P.K. Olshin, H. Müller, Nature Communications 17 (2026). das_tickbox: '1' dataavailabilitystatement: The simulated apoferritin exit wave and associated image simulation and analysis code used for generating the figures are available on Code Ocean (https://www.codeocean.com/). date_created: 2026-08-02T22:01:51Z date_published: 2026-06-05T00:00:00Z date_updated: 2026-08-05T09:27:39Z day: '05' ddc: - '530' department: - _id: MiLe doi: 10.1038/s41467-026-74060-6 file: - access_level: open_access checksum: 9bbcbaed3fd78e99cd728877332953c1 content_type: application/pdf creator: dernst date_created: 2026-08-03T06:48:08Z date_updated: 2026-08-03T06:48:08Z file_id: '22624' file_name: 2026_NatureComm_Petrov.pdf file_size: 2052058 relation: main_file success: 1 file_date_updated: 2026-08-03T06:48:08Z fulldoi: https://doi.org/10.1038/s41467-026-74060-6 has_accepted_license: '1' intvolume: ' 17' language: - iso: eng month: '06' oa: 1 oa_version: Published Version publication: Nature Communications publication_identifier: eissn: - 2041-1723 publication_status: published publisher: Springer Nature quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: yes title: Crossed laser phase plates for transmission electron microscopy tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 17 year: '2026' ... --- OA_type: closed access _id: '22365' abstract: - lang: eng text: Phase plates can, in principle, overcome the poor image contrast in cryo–electron microscopy (cryo-EM) and the resulting limits on the structural reconstruction of small proteins. However, previous designs have been unstable and compromised the high-resolution signal and have thus been unable to surpass results achieved by standard cryo-EM. Here, we show that the laser phase plate (LPP), installed in a modern, custom Titan Krios microscope, enhances the resolution in single-particle reconstruction of small proteins by improving specimen-motion correction and recovery of information from the early frames, as well as particle visualization, three-dimensional classification, and alignment. These advances use standard defocus ranges and reconstruction procedures but open the door to LPP-tailored protocols, offering further improvements by leveraging the LPP demonstrated here. acknowledgement: 'The authors thank O. Schwartz and S. Scheres for helpful remarks and discussions; D. Agard, B. Carragher, C. Potter, and P. Olshin for close collaboration; A. Singh, L. Maisenbacher, S. Strasser, and I. Pope for help with mirror inspection; J. Fang, E. Nogales, and J. Hurley for sharing their lab space and assisting with sample preparation; B. Buijsse, W. Hagen, B. Jiang, and T. Coyle at Thermo Fisher Scientific for the design of the custom transfer optics and technical support; G. Long and T. Gutierrez at the UC Berkeley Physics R&D Machine Shop for machining cavity components and tooling. This work was supported by the following: Chan Zuckerberg Initiative award numbers 2021-234606 and 2025-367757, National Institutes of Health grant R01GM126011, Gordon and Betty Moore Foundation grant 9366, Lawrence Berkeley National Laboratory Directed Research and Development Program grant 25-111, and Cooperative Research and Development Agreement award AWD00004352 (to H.M.); National Institutes of Health fellowship F32GM149186 (to P.N.P.).' article_processing_charge: No article_type: original author: - first_name: Petar N full_name: Petrov, Petar N id: b1d6732d-8cb6-11f0-baab-bd460ee3a287 last_name: Petrov - first_name: Jessie T. full_name: Zhang, Jessie T. last_name: Zhang - first_name: Jonathan full_name: Remis, Jonathan last_name: Remis - first_name: Jeremy J. full_name: Axelrod, Jeremy J. last_name: Axelrod - first_name: Hang full_name: Cheng, Hang last_name: Cheng - first_name: Eric S. full_name: Cooper, Eric S. last_name: Cooper - first_name: Ian K. full_name: Hicklin, Ian K. last_name: Hicklin - first_name: Shahar full_name: Sandhaus, Shahar last_name: Sandhaus - first_name: Cooper full_name: Schnurr, Cooper last_name: Schnurr - first_name: Robert M. full_name: Glaeser, Robert M. last_name: Glaeser - first_name: Holger full_name: Müller, Holger last_name: Müller citation: ama: Petrov PN, Zhang JT, Remis J, et al. Laser phase plate improves structure determination of small proteins by cryo-EM. Science. 2026;393(6807):195-196. doi:10.1126/science.aeh0665 apa: Petrov, P. N., Zhang, J. T., Remis, J., Axelrod, J. J., Cheng, H., Cooper, E. S., … Müller, H. (2026). Laser phase plate improves structure determination of small proteins by cryo-EM. Science. AAAS. https://doi.org/10.1126/science.aeh0665 chicago: Petrov, Petar N, Jessie T. Zhang, Jonathan Remis, Jeremy J. Axelrod, Hang Cheng, Eric S. Cooper, Ian K. Hicklin, et al. “Laser Phase Plate Improves Structure Determination of Small Proteins by Cryo-EM.” Science. AAAS, 2026. https://doi.org/10.1126/science.aeh0665. ieee: P. N. Petrov et al., “Laser phase plate improves structure determination of small proteins by cryo-EM,” Science, vol. 393, no. 6807. AAAS, pp. 195–196, 2026. ista: Petrov PN, Zhang JT, Remis J, Axelrod JJ, Cheng H, Cooper ES, Hicklin IK, Sandhaus S, Schnurr C, Glaeser RM, Müller H. 2026. Laser phase plate improves structure determination of small proteins by cryo-EM. Science. 393(6807), 195–196. mla: Petrov, Petar N., et al. “Laser Phase Plate Improves Structure Determination of Small Proteins by Cryo-EM.” Science, vol. 393, no. 6807, AAAS, 2026, pp. 195–96, doi:10.1126/science.aeh0665. short: P.N. Petrov, J.T. Zhang, J. Remis, J.J. Axelrod, H. Cheng, E.S. Cooper, I.K. Hicklin, S. Sandhaus, C. Schnurr, R.M. Glaeser, H. Müller, Science 393 (2026) 195–196. das_tickbox: '1' dataavailabilitystatement: 'The datasets are publicly available in the Electron Microscopy Public Image Archive [A1: EMPIAR-13528 (on), EMPIAR-13527 (off); A2: EMPIAR-13529 (on), EMPIAR-13526 (off); A3: EMPIAR-13530 (on), EMPIAR-13525 (off); H1: EMPIAR-13535 (on), EMPIAR-13533 (off); H2: EMPIAR-13534 (on), EMPIAR-13532 (off); H3: EMPIAR-13537 (on), EMPIAR-13531 (off)]. The final reconstructed maps are deposited in the Electron Microscopy Data Bank [A1: EMD-76790 (on), EMD-76791 (off); A2: EMD-76792 (on), EMD-76793 (off); A3: EMD-76794 (on), EMD-76797 (off); H1: EMD-76802 (on), EMD-76804 (off); H2: EMD-76805 (on), EMD-76806 (off); H3: EMD-76807 (on), EMD-76809 (off)]. The initial structures in Fig. 3 are deposited at EMD-76810 (on) and EMD-76811 (off). Code for converting EER movies to binned TIF format with proper accounting for electron dose is deposited in Zenodo (47) and available on GitHub at https://github.com/matterwaves/eer2tiff/releases/tag/v0.1.0. All specimen preparation materials are commercially available.' date_created: 2026-07-19T22:01:46Z date_published: 2026-07-09T00:00:00Z date_updated: 2026-08-05T09:27:38Z day: '09' ddc: - '570' department: - _id: MiLe doi: 10.1126/science.aeh0665 external_id: pmid: - '42275466' fulldoi: https://doi.org/10.1126/science.aeh0665 has_accepted_license: '1' intvolume: ' 393' issue: '6807' language: - iso: eng month: '07' oa_version: None page: 195-196 pmid: 1 publication: Science publication_identifier: eissn: - 1095-9203 issn: - 0036-8075 publication_status: published publisher: AAAS quality_controlled: '1' researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: yes title: Laser phase plate improves structure determination of small proteins by cryo-EM type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 393 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '22443' abstract: - lang: eng text: 'Society faces increasingly severe flood hazards, intensifying demand for flood early warning systems (FEWS) that deliver accurate and actionable information. However, most existing FEWS remain prediction‐centric, treating decision‐making as a downstream consumer of hazard forecasts while offering limited support for uncertainty interpretation, risk communication, and real‐world response. This Perspective presents a vision and blueprint for a novel inland FEWS‐decision‐making (FEWS‐DM) framework that repositions decision‐making as an equal partner in the forecasting process—not a passive recipient of its outputs. The framework is built on three tightly coupled, co‐evolving thrusts: Physical Science (T1), which advances flood prediction with quantified uncertainty informed by decision relevance; Human Science (T2), which incorporates psychology, behavior, and cultural and institutional context; and Decision Science (T3), which unifies physical predictions and human factors through principled, utility‐based decision support with end‐to‐end uncertainty management. Rather than treating T1 as a solved problem, FEWS‐DM recognizes that forecast development itself must be shaped by decision needs through continuous bidirectional feedback. We identify key scientific, behavioral, and operational challenges limiting such integration and discuss the enabling role of AI, while emphasizing human‐centered design and community feedback as essential for building trust and improving flood risk management.' article_number: e2026EF008857 article_processing_charge: No article_type: original author: - first_name: Vinh Ngoc full_name: Tran, Vinh Ngoc last_name: Tran - first_name: Xun full_name: Huan, Xun last_name: Huan - first_name: Anindya Das full_name: Antar, Anindya Das last_name: Antar - first_name: Nikola full_name: Banovic, Nikola last_name: Banovic - first_name: Jeff H. full_name: Bednar, Jeff H. last_name: Bednar - first_name: Shannon Marie full_name: Bergt, Shannon Marie last_name: Bergt - first_name: Chen full_name: Cheng, Chen last_name: Cheng - first_name: Francina full_name: Dominguez, Francina last_name: Dominguez - first_name: Simone full_name: Fatichi, Simone id: cf8e546b-a9b0-11f0-a43b-aa89ed1b56d6 last_name: Fatichi - first_name: Richard full_name: Gonzalez, Richard last_name: Gonzalez - first_name: Kevin full_name: Gray, Kevin last_name: Gray - first_name: Brian full_name: Jewett, Brian last_name: Jewett - first_name: Jongho full_name: Kim, Jongho last_name: Kim - first_name: Phong V.V. full_name: Le, Phong V.V. last_name: Le - first_name: Dan full_name: Lu, Dan last_name: Lu - first_name: Snehal full_name: Prabhudesai, Snehal last_name: Prabhudesai - first_name: Deffi full_name: Putri, Deffi last_name: Putri - first_name: Sudhansu full_name: Rath, Sudhansu last_name: Rath - first_name: Khachik full_name: Sargsyan, Khachik last_name: Sargsyan - first_name: Sarah H. full_name: Whitaker, Sarah H. last_name: Whitaker - first_name: Daniel B. full_name: Wright, Daniel B. last_name: Wright - first_name: Donghui full_name: Xu, Donghui last_name: Xu - first_name: John P. full_name: Ziker, John P. last_name: Ziker - first_name: Valeriy Y. full_name: Ivanov, Valeriy Y. last_name: Ivanov citation: ama: Tran VN, Huan X, Antar AD, et al. Reimagining how flood warnings can inform decision‐making and community actions. Earth’s Future. 2026;14(6). doi:10.1029/2026ef008857 apa: Tran, V. N., Huan, X., Antar, A. D., Banovic, N., Bednar, J. H., Bergt, S. M., … Ivanov, V. Y. (2026). Reimagining how flood warnings can inform decision‐making and community actions. Earth’s Future. American Geophysical Union. https://doi.org/10.1029/2026ef008857 chicago: Tran, Vinh Ngoc, Xun Huan, Anindya Das Antar, Nikola Banovic, Jeff H. Bednar, Shannon Marie Bergt, Chen Cheng, et al. “Reimagining How Flood Warnings Can Inform Decision‐making and Community Actions.” Earth’s Future. American Geophysical Union, 2026. https://doi.org/10.1029/2026ef008857. ieee: V. N. Tran et al., “Reimagining how flood warnings can inform decision‐making and community actions,” Earth’s Future, vol. 14, no. 6. American Geophysical Union, 2026. ista: Tran VN, Huan X, Antar AD, Banovic N, Bednar JH, Bergt SM, Cheng C, Dominguez F, Fatichi S, Gonzalez R, Gray K, Jewett B, Kim J, Le PVV, Lu D, Prabhudesai S, Putri D, Rath S, Sargsyan K, Whitaker SH, Wright DB, Xu D, Ziker JP, Ivanov VY. 2026. Reimagining how flood warnings can inform decision‐making and community actions. Earth’s Future. 14(6), e2026EF008857. mla: Tran, Vinh Ngoc, et al. “Reimagining How Flood Warnings Can Inform Decision‐making and Community Actions.” Earth’s Future, vol. 14, no. 6, e2026EF008857, American Geophysical Union, 2026, doi:10.1029/2026ef008857. short: V.N. Tran, X. Huan, A.D. Antar, N. Banovic, J.H. Bednar, S.M. Bergt, C. Cheng, F. Dominguez, S. Fatichi, R. Gonzalez, K. Gray, B. Jewett, J. Kim, P.V.V. Le, D. Lu, S. Prabhudesai, D. Putri, S. Rath, K. Sargsyan, S.H. Whitaker, D.B. Wright, D. Xu, J.P. Ziker, V.Y. Ivanov, Earth’s Future 14 (2026). das_tickbox: '1' date_created: 2026-07-27T12:30:23Z date_published: 2026-06-01T00:00:00Z date_updated: 2026-08-06T09:02:33Z day: '01' doi: 10.1029/2026ef008857 extern: '1' fulldoi: https://doi.org/10.1029/2026ef008857 intvolume: ' 14' issue: '6' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1029/2026EF008857 month: '06' oa: 1 oa_version: Published Version publication: Earth's Future publication_identifier: eissn: - 2328-4277 publication_status: published publisher: American Geophysical Union quality_controlled: '1' scopus_import: '1' status: public title: Reimagining how flood warnings can inform decision‐making and community actions tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 14 year: '2026' ... --- OA_place: repository OA_type: free access _id: '21381' abstract: - lang: eng text: 'The lack of long-range electrostatics is a key limitation of modern machine learning interatomic potentials (MLIPs), hindering reliable applications to interfaces, charge-transfer reactions, polar and ionic materials, and biomolecules. In this Perspective, we distill two design principles behind the Latent Ewald Summation framework, which can capture long-range interactions, charges, and electrical response just by learning from standard energy and force training data: (i) use a Coulomb functional form with environment-dependent charges to capture electrostatic interactions, and (ii) avoid explicit training on ambiguous density functional theory partial charges. When both principles are satisfied, substantial flexibility remains: essentially any short-range MLIP can be augmented; charge equilibration schemes can be added when desired; dipoles and Born effective charges can be inferred or fine-tuned; and charge/spin-state embeddings or tensorial targets can be further incorporated. We also discuss current limitations and open challenges. Together, these minimal, physics-guided design rules suggest that incorporating long-range electrostatics into MLIPs is simpler and perhaps more broadly applicable than is commonly assumed.' acknowledgement: "B.C. thanks Christoph Dellago for his mentorship and influence. In addition to his seminal contributions to statistical mechanics, Christoph Dellago is an early developer and adopter of machine learning interatomic potentials. B.C. did two exchanges in the groups of Christoph Dellago and Jörg Behler in 2018, with transformative impact on her research directions.\r\n\r\nWe thank Peichen Zhong and Daniel S. King for useful feedback on the manuscript and for the collaborations on the LES method.\r\n\r\nFunding acknowledgment: Research reported in this publication was supported by the National Institute Of General Medical Sciences of the National Institutes of Health under Award No. R35GM159986. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health." article_number: '060901' article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Dongjin full_name: Kim, Dongjin last_name: Kim - first_name: Bingqing full_name: Cheng, Bingqing id: cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9 last_name: Cheng orcid: 0000-0002-3584-9632 citation: ama: Kim D, Cheng B. Long-range electrostatics for machine learning interatomic potentials is easier than we thought. The Journal of Chemical Physics. 2026;164(6). doi:10.1063/5.0316886 apa: Kim, D., & Cheng, B. (2026). Long-range electrostatics for machine learning interatomic potentials is easier than we thought. The Journal of Chemical Physics. AIP Publishing. https://doi.org/10.1063/5.0316886 chicago: Kim, Dongjin, and Bingqing Cheng. “Long-Range Electrostatics for Machine Learning Interatomic Potentials Is Easier than We Thought.” The Journal of Chemical Physics. AIP Publishing, 2026. https://doi.org/10.1063/5.0316886. ieee: D. Kim and B. Cheng, “Long-range electrostatics for machine learning interatomic potentials is easier than we thought,” The Journal of Chemical Physics, vol. 164, no. 6. AIP Publishing, 2026. ista: Kim D, Cheng B. 2026. Long-range electrostatics for machine learning interatomic potentials is easier than we thought. The Journal of Chemical Physics. 164(6), 060901. mla: Kim, Dongjin, and Bingqing Cheng. “Long-Range Electrostatics for Machine Learning Interatomic Potentials Is Easier than We Thought.” The Journal of Chemical Physics, vol. 164, no. 6, 060901, AIP Publishing, 2026, doi:10.1063/5.0316886. short: D. Kim, B. Cheng, The Journal of Chemical Physics 164 (2026). corr_author: '1' das_tickbox: '1' dataavailabilitystatement: "The RPBE-D3 bulk water dataset, training scripts, evaluation scripts, the trained CACE E + F + Qeq model, and CACE LES and MACE LES models used to produce results shown in Figs. 2(c)–2(e) are available at https://github.com/ChengUCB/les_fit.\r\n\r\nThe LES library is publicly available at https://github.com/ChengUCB/les. The CACE package with the LES implementation is available at https://github.com/BingqingCheng/cace. The MACE package with the LES implementation is available at https://github.com/ACEsuit/mace. The NequIP and Allegro LES extension package is available at https://github.com/ChengUCB/NequIP-LES. The MatGL package with the LES implementation is available at https://github.com/ChengUCB/matgl. The UMA package with the LES implementation is available at https://github.com/santi921/fairchem/tree/les_branch." date_created: 2026-03-02T10:06:46Z date_published: 2026-02-14T00:00:00Z date_updated: 2026-08-07T09:33:14Z day: '14' department: - _id: BiCh doi: 10.1063/5.0316886 external_id: arxiv: - '2512.18029' fulldoi: https://doi.org/10.1063/5.0316886 intvolume: ' 164' issue: '6' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2512.18029 month: '02' oa: 1 oa_version: Preprint publication: The Journal of Chemical Physics publication_identifier: eissn: - 1089-7690 issn: - 0021-9606 publication_status: published publisher: AIP Publishing quality_controlled: '1' researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: no title: Long-range electrostatics for machine learning interatomic potentials is easier than we thought type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 164 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '22441' abstract: - lang: eng text: Warming impacts both net primary production (NPP) and soil organic carbon (SOC) decomposition, and consequently, SOC storage. However, the role of warming in regulating SOC storage remains debated. Here, we leverage literature data of warming experiments and a mechanistic model to explore SOC responses to warming by partitioning the effects of air and soil warming. Both the literature data and numerical model show that air and soil warming play distinct roles in regulating SOC storage, with insignificant SOC responses under air warming and negative responses to soil warming. Soil warming decreases SOC storage because of temperature-driven increases in decomposition rate. Air warming effects on SOC are more complex. In some cases, air warming can lead to a lower NPP and higher decomposition rate. In others, air warming can stimulate NPP and enhance soil moisture depletion that inhibits SOC decomposition. Once the latter mechanisms dominate, SOC storage increases with air warming. article_number: '394' article_processing_charge: No article_type: original author: - first_name: Zhaoyang full_name: Luo, Zhaoyang last_name: Luo - first_name: Jianning full_name: Ren, Jianning last_name: Ren - first_name: Simone full_name: Fatichi, Simone id: cf8e546b-a9b0-11f0-a43b-aa89ed1b56d6 last_name: Fatichi citation: ama: Luo Z, Ren J, Fatichi S. Air and soil warming have different effects on soil organic carbon storage. Communications Earth & Environment. 2026;7. doi:10.1038/s43247-026-03367-5 apa: Luo, Z., Ren, J., & Fatichi, S. (2026). Air and soil warming have different effects on soil organic carbon storage. Communications Earth & Environment. Springer Nature. https://doi.org/10.1038/s43247-026-03367-5 chicago: Luo, Zhaoyang, Jianning Ren, and Simone Fatichi. “Air and Soil Warming Have Different Effects on Soil Organic Carbon Storage.” Communications Earth & Environment. Springer Nature, 2026. https://doi.org/10.1038/s43247-026-03367-5. ieee: Z. Luo, J. Ren, and S. Fatichi, “Air and soil warming have different effects on soil organic carbon storage,” Communications Earth & Environment, vol. 7. Springer Nature, 2026. ista: Luo Z, Ren J, Fatichi S. 2026. Air and soil warming have different effects on soil organic carbon storage. Communications Earth & Environment. 7, 394. mla: Luo, Zhaoyang, et al. “Air and Soil Warming Have Different Effects on Soil Organic Carbon Storage.” Communications Earth & Environment, vol. 7, 394, Springer Nature, 2026, doi:10.1038/s43247-026-03367-5. short: Z. Luo, J. Ren, S. Fatichi, Communications Earth & Environment 7 (2026). das_tickbox: '1' date_created: 2026-07-27T12:30:23Z date_published: 2026-05-05T00:00:00Z date_updated: 2026-08-07T09:28:26Z day: '05' doi: 10.1038/s43247-026-03367-5 extern: '1' fulldoi: https://doi.org/10.1038/s43247-026-03367-5 intvolume: ' 7' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1038/s43247-026-03367-5 month: '05' oa: 1 oa_version: Published Version publication: Communications Earth & Environment publication_identifier: eissn: - 2662-4435 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: Air and soil warming have different effects on soil organic carbon storage tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 7 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '22528' abstract: - lang: eng text: Quantification of the impact of environmental stress on terrestrial vegetation photosynthesis is crucial for our understanding of the global carbon cycle, particularly under a changing climate. Vegetation responses to environmental stress manifest first as plant physiological changes, and at later stages through changes in canopy structure. Here we leverage CO2 and water flux data from 103 eddy covariance towers and satellite thermal images to assess whether current satellite reconstructions of solar-induced chlorophyll fluorescence capture these plant mechanisms. After removing seasonality using standardized anomalies (z-scores), we found that the relationship between tower-observed gross primary productivity and fluorescence reconstructions considerably weakened across a wide range of biomes. This loss of correlation results from a decoupling between stomatal responses and the physiological emission yield (ΦF) of fluorescence reconstructions during soil and atmospheric dry periods. The consequence is that productivity derived from fluorescence reconstructions will be progressively overestimated as dry conditions persist. article_number: '9' article_processing_charge: No article_type: original author: - first_name: Jiacheng full_name: Zhao, Jiacheng last_name: Zhao - first_name: Athanasios full_name: Paschalis, Athanasios last_name: Paschalis - first_name: Pierre full_name: Gentine, Pierre last_name: Gentine - first_name: Zhaozhong full_name: Feng, Zhaozhong last_name: Feng - first_name: Simone full_name: Fatichi, Simone id: cf8e546b-a9b0-11f0-a43b-aa89ed1b56d6 last_name: Fatichi citation: ama: Zhao J, Paschalis A, Gentine P, Feng Z, Fatichi S. Limited capability of current satellite solar-induced chlorophyll fluorescence reconstructions to capture stomatal responses to environmental stresses. Communications Earth & Environment. 2026;7. doi:10.1038/s43247-025-03035-0 apa: Zhao, J., Paschalis, A., Gentine, P., Feng, Z., & Fatichi, S. (2026). Limited capability of current satellite solar-induced chlorophyll fluorescence reconstructions to capture stomatal responses to environmental stresses. Communications Earth & Environment. Springer Nature. https://doi.org/10.1038/s43247-025-03035-0 chicago: Zhao, Jiacheng, Athanasios Paschalis, Pierre Gentine, Zhaozhong Feng, and Simone Fatichi. “Limited Capability of Current Satellite Solar-Induced Chlorophyll Fluorescence Reconstructions to Capture Stomatal Responses to Environmental Stresses.” Communications Earth & Environment. Springer Nature, 2026. https://doi.org/10.1038/s43247-025-03035-0. ieee: J. Zhao, A. Paschalis, P. Gentine, Z. Feng, and S. Fatichi, “Limited capability of current satellite solar-induced chlorophyll fluorescence reconstructions to capture stomatal responses to environmental stresses,” Communications Earth & Environment, vol. 7. Springer Nature, 2026. ista: Zhao J, Paschalis A, Gentine P, Feng Z, Fatichi S. 2026. Limited capability of current satellite solar-induced chlorophyll fluorescence reconstructions to capture stomatal responses to environmental stresses. Communications Earth & Environment. 7, 9. mla: Zhao, Jiacheng, et al. “Limited Capability of Current Satellite Solar-Induced Chlorophyll Fluorescence Reconstructions to Capture Stomatal Responses to Environmental Stresses.” Communications Earth & Environment, vol. 7, 9, Springer Nature, 2026, doi:10.1038/s43247-025-03035-0. short: J. Zhao, A. Paschalis, P. Gentine, Z. Feng, S. Fatichi, Communications Earth & Environment 7 (2026). das_tickbox: '1' date_created: 2026-07-27T12:30:24Z date_published: 2026-01-05T00:00:00Z date_updated: 2026-08-07T10:34:55Z day: '05' doi: 10.1038/s43247-025-03035-0 extern: '1' fulldoi: https://doi.org/10.1038/s43247-025-03035-0 intvolume: ' 7' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1038/s43247-025-03035-0 month: '01' oa: 1 oa_version: Published Version publication: Communications Earth & Environment publication_identifier: eissn: - 2662-4435 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: Limited capability of current satellite solar-induced chlorophyll fluorescence reconstructions to capture stomatal responses to environmental stresses tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 7 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: diamond PlanS_conform: '1' _id: '22663' abstract: - lang: eng text: The detection of strong, large-scale magnetic fields at the surfaces of the oldest white dwarfs might point toward a hidden internal magnetic field slowly rising to the surface. In addition, strong magnetic fields have recently been measured through asteroseismology in the radiative interiors of red giant stars, the progenitors of white dwarfs. To investigate the potential connection between these observations, we revisited the fossil field framework using asteroseismic detections to constrain the strength of such magnetic fields as red giants evolve into the white dwarf stage. We assumed that the magnetic field was either created during the core convection on the main sequence or that it fills the radiative interior as the star evolves on the red giant branch. From these initial conditions, we evolved the magnetic flux, allowing for magnetic diffusion along the evolution of a modeled 1.5 M⊙ star. We find that measured field strengths in red giants attributed to the hydrogen-burning shell are compatible with the field amplitudes and emergence timescales of magnetized white dwarfs. On the contrary, magnetic fields generated solely from a convective-core dynamo on the main sequence and detectable on the red giant branch would be buried too deep in the star and would not match the breakout timescales or the field strengths of magnetic white dwarfs. Therefore, for us to connect magnetic fields observed along the late evolution of stars via a fossil field we would need to find a broadly magnetized internal radiative zone on the red giant branch. acknowledgement: "The authors thank the referee for their helpful and constructive report, which has significantly enhanced the quality of the manuscript.\r\nThe authors thank I. Caiazzo, L. Ferrario, and L. Buchele for very useful discussions. L. Barrault, L. Bugnet, and L. Einramhof gratefully acknowledge support from the European Research Council (ERC) under the Horizon Europe\r\nprogramme (Calcifer; Starting Grant agreement N◦101165631). L. Barrault\r\nacknowledges the support of the Austrian Academy of Sciences through the Doctoral Fellowship Programme (DOC) of the Austrian Academy of Sciences 27648.\r\nWhile partially funded by the European Union, views and opinions expressed\r\nare, however, those of the authors only and do not necessarily reflect those of the European Union or the European Research Council. Neither the European Union\r\nnor the granting authority can be held responsible for them." article_number: L14 article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Lukas full_name: Einramhof, Lukas id: f1497a1a-72ef-11ef-b75a-fd877bbf6e8c last_name: Einramhof - first_name: Lisa Annabelle full_name: Bugnet, Lisa Annabelle id: d9edb345-f866-11ec-9b37-d119b5234501 last_name: Bugnet orcid: 0000-0003-0142-4000 - first_name: L. M. full_name: Calcaferro, L. M. last_name: Calcaferro - first_name: Lucas full_name: Barrault, Lucas id: 4471a8fd-32c1-11ee-a9a4-fb670d398f64 last_name: Barrault - first_name: S. B. full_name: Das, S. B. last_name: Das citation: ama: Einramhof L, Bugnet LA, Calcaferro LM, Barrault L, Das SB. Magneto-archeology of white dwarfs. Astronomy & Astrophysics. 2026;708. doi:10.1051/0004-6361/202659069 apa: Einramhof, L., Bugnet, L. A., Calcaferro, L. M., Barrault, L., & Das, S. B. (2026). Magneto-archeology of white dwarfs. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202659069 chicago: Einramhof, Lukas, Lisa Annabelle Bugnet, L. M. Calcaferro, Lucas Barrault, and S. B. Das. “Magneto-Archeology of White Dwarfs.” Astronomy & Astrophysics. EDP Sciences, 2026. https://doi.org/10.1051/0004-6361/202659069. ieee: L. Einramhof, L. A. Bugnet, L. M. Calcaferro, L. Barrault, and S. B. Das, “Magneto-archeology of white dwarfs,” Astronomy & Astrophysics, vol. 708. EDP Sciences, 2026. ista: Einramhof L, Bugnet LA, Calcaferro LM, Barrault L, Das SB. 2026. Magneto-archeology of white dwarfs. Astronomy & Astrophysics. 708, L14. mla: Einramhof, Lukas, et al. “Magneto-Archeology of White Dwarfs.” Astronomy & Astrophysics, vol. 708, L14, EDP Sciences, 2026, doi:10.1051/0004-6361/202659069. short: L. Einramhof, L.A. Bugnet, L.M. Calcaferro, L. Barrault, S.B. Das, Astronomy & Astrophysics 708 (2026). corr_author: '1' das_tickbox: '1' dataavailabilitystatement: We used MESA version 24.08.1. All inlists and relevant files are available on Zenodo at https://doi.org/10.5281/zenodo.19232789 date_created: 2026-08-10T07:53:32Z date_published: 2026-04-01T00:00:00Z date_updated: 2026-08-11T05:49:20Z day: '01' ddc: - '520' department: - _id: LiBu - _id: GradSch doi: 10.1051/0004-6361/202659069 external_id: arxiv: - '2601.15203' file: - access_level: open_access checksum: 61edee776603d7b879b06b3ea8d2bc89 content_type: application/pdf creator: dernst date_created: 2026-08-11T05:46:02Z date_updated: 2026-08-11T05:46:02Z file_id: '22671' file_name: 2026_AstronomyAstrophysics_Einramhof.pdf file_size: 3739424 relation: main_file success: 1 file_date_updated: 2026-08-11T05:46:02Z fulldoi: https://doi.org/10.1051/0004-6361/202659069 has_accepted_license: '1' intvolume: ' 708' language: - iso: eng month: '04' oa: 1 oa_version: Published Version project: - _id: 914d8549-16d5-11f0-9cad-bbe6324c93a9 grant_number: '101165631' name: 'Unveiling the mysteries of stellar dynamics: a pioneering journey in magnetoasteroseismology' - _id: 5b62812b-ab3d-11f0-914f-8f3a9cdb4af7 grant_number: '27648' name: Unveiling the structure and dynamics of the deep convective core - radiative zone boundary throughout stellar evolution publication: Astronomy & Astrophysics publication_identifier: eissn: - 1432-0746 issn: - 0004-6361 publication_status: published publisher: EDP Sciences quality_controlled: '1' researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: yes title: Magneto-archeology of white dwarfs tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 708 year: '2026' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '22648' abstract: - lang: eng text: Bifurcation characterizes the qualitative changes in parameterized dynamical systems and is one of the major topics in the field. In this work, we study combinatorial bifurcations within the framework of combinatorial dynamical systems—a young but already well-established theory. We introduce the Conley–Morse persistence barcode, a compact algebraic descriptor of combinatorial bifurcations. This barcode captures structural changes in a dynamical system at the level of Morse decompositions and provides a characterization of the nature of observed transitions in terms of the Conley index. The construction of the Conley–Morse persistence barcode builds upon ideas from topological persistence. Specifically, we consider a persistence module obtained from the Conley index of invariant sets indexed over a poset. Using gentle algebras, we prove that this module decomposes into simple intervals (bars) and compute them by adapting the zigzag persistence algorithm to our purpose. acknowledgement: M.L. acknowledges support from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 101034413. T.D. acknowledges the support of NSF funds CCF-2437030 and DMS-2301360. The authors would like to thank the anonymous reviewers for their careful reading of the paper. Their feedback significantly improved the quality of the article. T.D. and M.L. would like to acknowledge many thought-provoking discussions with Marian Mrozek on combinatorial dynamical systems and their continuations. M.S.T. would like to thank Álvaro Sánchez for insightful discussions about representation theory. Open access funding provided by Institute of Science and Technology (IST Austria). article_processing_charge: Yes (via OA deal) article_type: original arxiv: 1 author: - first_name: Tamal K. full_name: Dey, Tamal K. last_name: Dey - first_name: Michał full_name: Lipiński, Michał id: dfffb474-4317-11ee-8f5c-fe3fc95a425e last_name: Lipiński orcid: 0000-0001-9789-9750 - first_name: Manuel full_name: Soriano Trigueros, Manuel id: 15ebd7cf-15bf-11ee-aebd-bb4bb5121ea8 last_name: Soriano Trigueros orcid: 0000-0003-2449-1433 citation: ama: 'Dey TK, Lipiński M, Soriano Trigueros M. Conley-Morse persistence barcode: A homological signature of combinatorial bifurcations. Foundations of Computational Mathematics. 2026. doi:10.1007/s10208-026-09766-6' apa: 'Dey, T. K., Lipiński, M., & Soriano Trigueros, M. (2026). Conley-Morse persistence barcode: A homological signature of combinatorial bifurcations. Foundations of Computational Mathematics. Springer. https://doi.org/10.1007/s10208-026-09766-6' chicago: 'Dey, Tamal K., Michał Lipiński, and Manuel Soriano Trigueros. “Conley-Morse Persistence Barcode: A Homological Signature of Combinatorial Bifurcations.” Foundations of Computational Mathematics. Springer, 2026. https://doi.org/10.1007/s10208-026-09766-6.' ieee: 'T. K. Dey, M. Lipiński, and M. Soriano Trigueros, “Conley-Morse persistence barcode: A homological signature of combinatorial bifurcations,” Foundations of Computational Mathematics. Springer, 2026.' ista: 'Dey TK, Lipiński M, Soriano Trigueros M. 2026. Conley-Morse persistence barcode: A homological signature of combinatorial bifurcations. Foundations of Computational Mathematics.' mla: 'Dey, Tamal K., et al. “Conley-Morse Persistence Barcode: A Homological Signature of Combinatorial Bifurcations.” Foundations of Computational Mathematics, Springer, 2026, doi:10.1007/s10208-026-09766-6.' short: T.K. Dey, M. Lipiński, M. Soriano Trigueros, Foundations of Computational Mathematics (2026). corr_author: '1' das_tickbox: '0' date_created: 2026-08-05T06:11:30Z date_published: 2026-08-04T00:00:00Z date_updated: 2026-08-11T06:13:33Z day: '04' ddc: - '500' department: - _id: HeEd doi: 10.1007/s10208-026-09766-6 ec_funded: 1 external_id: arxiv: - '2504.17105' fulldoi: https://doi.org/10.1007/s10208-026-09766-6 has_accepted_license: '1' keyword: - Multivector field - Conley index - Morse decomposition - Bifurcation - Continuation - Zigzag persistence - Persistence barcode - Gentle algebra language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1007/s10208-026-09766-6 month: '08' oa: 1 oa_version: Published Version project: - _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c call_identifier: H2020 grant_number: '101034413' name: 'IST-BRIDGE: International postdoctoral program' publication: Foundations of Computational Mathematics publication_identifier: eissn: - 1615-3383 issn: - 1615-3375 publication_status: epub_ahead publisher: Springer quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: yes title: 'Conley-Morse persistence barcode: A homological signature of combinatorial bifurcations' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '22677' abstract: - lang: eng text: "Study region: The Vilcanota Urubamba Basin in southern Peru includes fragile wetland ecosystems that play a key role in mountain hydrology and support grazing for Andean communities.\r\nStudy focus: Mapping of wetlands variability is missing, limiting our understanding of their characteristics, seasonality and link with the cryosphere. We characterise wetland distribution, seasonality and persistence and evaluate their spatial association with glaciers and seasonal snow. Using Landsat 7 and 8 imagery, we build three-month seasonal land cover maps from 2013 to 2022 using a Random Forest classification and an Albedo Retrieval approach.\r\nNew hydrological insights for the region: Wetland area decreases by 38% from the end of the wet season (October to December) to the end of the dry season (July to September). Pixel transitions indicate that wetlands primarily transform to and from agricultural and pasture lands. Highly persistent wetlands are located above 4600 m a.s.l. and closer to glaciers than less persistent wetlands. We identified three wetland seasonal drying patterns. Basins with delayed and slow dry-out wetlands were more common at higher elevations but were not always in glacierised catchments, suggesting meltwater may maintain wetlands in the early dry season. We provide the first large-scale picture of wetland seasonality, and the basis for modelling the processes that sustain wetlands in tropical high mountains." acknowledgement: 'Joshua Castro acknowledges the support and funding of the Swiss Government Excellence Scholarships (ESKAS-Nr: 2022.0416) and the Doc. Mobility program by the University of Fribourg. Catriona Fyffe acknowledges support from the Marie Skłodowska-Curie Action project EPIC, which was funded by the European Union (grant number 101105480). Francesca Pellicciotti and Vinisha Varghese acknowledge support from the SNSF-funded PASTURE project, grant no. 202604. Emily Potter was jointly funded by a Leverhulme Trust ECR fellowship and NERC grant NE/X004031/1. We thank Miguel Vargas from the Universidad Nacional San Antonio Abad del Cusco for providing the validation points dataset used in this work.' article_number: '103808' article_processing_charge: Yes article_type: original author: - first_name: Joshua full_name: Castro, Joshua last_name: Castro - first_name: Catriona Louise full_name: Fyffe, Catriona Louise id: 001b0422-8d15-11ed-bc51-cab6c037a228 last_name: Fyffe - first_name: Thomas full_name: Shaw, Thomas id: 3caa3f91-1f03-11ee-96ce-e0e553054d6e last_name: Shaw orcid: 0000-0001-7640-6152 - first_name: Evan full_name: Miles, Evan last_name: Miles - first_name: Emily full_name: Potter, Emily last_name: Potter - first_name: Martin full_name: Hoelzle, Martin last_name: Hoelzle - first_name: Vinisha full_name: Varghese, Vinisha last_name: Varghese - first_name: Francesca full_name: Pellicciotti, Francesca id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70 last_name: Pellicciotti orcid: 0000-0002-5554-8087 citation: ama: 'Castro J, Fyffe CL, Shaw T, et al. Andean wetlands: Seasonal variability and their interactions with the cryosphere. Journal of Hydrology: Regional Studies. 2026;67. doi:10.1016/j.ejrh.2026.103808' apa: 'Castro, J., Fyffe, C. L., Shaw, T., Miles, E., Potter, E., Hoelzle, M., … Pellicciotti, F. (2026). Andean wetlands: Seasonal variability and their interactions with the cryosphere. Journal of Hydrology: Regional Studies. Elsevier. https://doi.org/10.1016/j.ejrh.2026.103808' chicago: 'Castro, Joshua, Catriona Louise Fyffe, Thomas Shaw, Evan Miles, Emily Potter, Martin Hoelzle, Vinisha Varghese, and Francesca Pellicciotti. “Andean Wetlands: Seasonal Variability and Their Interactions with the Cryosphere.” Journal of Hydrology: Regional Studies. Elsevier, 2026. https://doi.org/10.1016/j.ejrh.2026.103808.' ieee: 'J. Castro et al., “Andean wetlands: Seasonal variability and their interactions with the cryosphere,” Journal of Hydrology: Regional Studies, vol. 67. Elsevier, 2026.' ista: 'Castro J, Fyffe CL, Shaw T, Miles E, Potter E, Hoelzle M, Varghese V, Pellicciotti F. 2026. Andean wetlands: Seasonal variability and their interactions with the cryosphere. Journal of Hydrology: Regional Studies. 67, 103808.' mla: 'Castro, Joshua, et al. “Andean Wetlands: Seasonal Variability and Their Interactions with the Cryosphere.” Journal of Hydrology: Regional Studies, vol. 67, 103808, Elsevier, 2026, doi:10.1016/j.ejrh.2026.103808.' short: 'J. Castro, C.L. Fyffe, T. Shaw, E. Miles, E. Potter, M. Hoelzle, V. Varghese, F. Pellicciotti, Journal of Hydrology: Regional Studies 67 (2026).' das_tickbox: '1' dataavailabilitystatement: Research Data and script is available in https://doi.org/10.5281/zenodo.18508189. date_created: 2026-08-11T06:19:46Z date_published: 2026-07-30T00:00:00Z date_updated: 2026-08-11T06:48:28Z day: '30' ddc: - '550' department: - _id: FrPe doi: 10.1016/j.ejrh.2026.103808 file: - access_level: open_access checksum: 6a6545fc11b6c7948cdede877d19e3f3 content_type: application/pdf creator: dernst date_created: 2026-08-11T06:45:46Z date_updated: 2026-08-11T06:45:46Z file_id: '22680' file_name: 2026_JourHydrology_Castro.pdf file_size: 13155535 relation: main_file success: 1 file_date_updated: 2026-08-11T06:45:46Z fulldoi: https://doi.org/10.1016/j.ejrh.2026.103808 has_accepted_license: '1' intvolume: ' 67' language: - iso: eng month: '07' oa: 1 oa_version: Published Version project: - _id: bdbe6627-d553-11ed-ba76-b5c9eedf278f grant_number: '101105480' name: ExPloring the ecohydrological Impacts of a changing Cryosphere in the Peruvian Andes publication: 'Journal of Hydrology: Regional Studies' publication_identifier: eissn: - 2214-5818 publication_status: published publisher: Elsevier quality_controlled: '1' researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: yes title: 'Andean wetlands: Seasonal variability and their interactions with the cryosphere' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 67 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '22675' abstract: - lang: eng text: "Tidal disruption events (TDEs) have traditionally been discovered in optical sky surveys through targeted searches of nuclear transients. However, it is expected that some TDEs will occur outside the galaxy nucleus, arising from wandering black holes (BHs) originating in galaxy mergers. Here, we present observations of TDE 2025abcr, the first optical TDE discovered in the outskirts of a host galaxy. The TDE was identified by a custom “off-nuclear” implementation of the machine learning classifier tdescore, which classifies new ZTF transients based on their lightcurves. Follow-up observations confirm that TDE 2025abcr is a TDE-H+He, occurring 9\r\n5 (9.3 kpc projected distance) from the nucleus of a massive galaxy (M⋆ = 1011.18±0.03M⊙) with a central BH mass of 108.82±0.65M⊙. TDE 2025abcr itself was likely disrupted by a much lighter BH (106.09±0.53M⊙, as estimated with peak luminosity scaling relations). The BH was either dynamically ejected from the nucleus or lies at the center of a very faint tidally stripped dwarf galaxy undergoing a minor merger. Late-time observations of TDE 2025abcr could confirm the origin of this apparent “wandering” BH. The rate of highly offset (≳3 kpc) TDEs can be constrained to <10% of the nuclear TDE rate, but our discovery implies that many dozens of similar sources will be detected by the Vera C. Rubin Observatory each year with resolvable offsets." acknowledgement: "We thank Muryel Guolo, Dan Perley, and Carl Rodriguez for the fruitful discussions about off-nuclear TDEs.\r\n\r\nBased on observations obtained with the Samuel Oschin Telescope 48-inch and the 60-inch Telescope at the Palomar Observatory as part of the ZTF project. ZTF is supported by the National Science Foundation under award #2407588 and a partnership including Caltech, USA; Caltech/IPAC, USA; University of Maryland, USA; University of California, Berkeley, USA; Cornell University, USA; Drexel University, USA; University of North Carolina at Chapel Hill, USA; Institute of Science and Technology, Austria; National Central University, Taiwan, and the German Center for Astrophysics (DZA), Germany. Operations are conducted by Caltech’s Optical Observatory (COO), Caltech/IPAC, and the University of Washington at Seattle, USA.\r\n\r\nSED Machine is based upon work supported by the National Science Foundation under grant No. 1106171.\r\n\r\nThe Gordon and Betty Moore Foundation, through both the Data-Driven Investigator Program and a dedicated grant, provided critical funding for SkyPortal.\r\n\r\nThese results were obtained with the use of LDT, owned and operated by the Lowell Observatory\r\n\r\nSome of the data presented herein were obtained at Keck Observatory, which is a private 501(c)3 nonprofit organization operated as a scientific partnership among the California Institute of Technology, the University of California, and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W. M. Keck Foundation. The authors wish to recognize and acknowledge the very significant cultural role and reverence that the summit of Maunakea has always had within the Native Hawaiian community. We are most fortunate to have the opportunity to conduct observations from this mountain.\r\n\r\nA major upgrade of the Kast spectrograph on the Shane 3 m telescope at Lick Observatory, led by Brad Holden, was made possible through gifts from the Heising-Simons Foundation, William and Marina Kast, and the University of California Observatories. Research at Lick Observatory is partially supported by a generous gift from Google.\r\n\r\nThis work is based (in part) on observations made with NOT, owned in collaboration by the University of Turku and Aarhus University, and operated jointly by Aarhus University, the University of Turku and the University of Oslo, representing Denmark, Finland and Norway, the University of Iceland and Stockholm University at the Observatorio del Roque de los Muchachos, La Palma, Spain, of the Instituto de Astrofisica de Canarias under NOT programmes 72-504. The NOT data presented here were obtained with ALFOSC, which is provided by the Instituto de Astrofisica de Andalucia (IAA) under a joint agreement with the University of Copenhagen and NOT.\r\n\r\nThis work made use of data supplied by the UK Swift Science Data Centre at the University of Leicester.\r\n\r\nThis paper contains data obtained at the Wendelstein Observatory of the Ludwig-Maximilians University Munich. We thank Christoph Ries for carrying out the observations. Funded in part by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy—EXC-2094/2—390783311.\r\n\r\nThe national facility capability for SkyMapper has been funded through ARC LIEF grant LE130100104 from the Australian Research Council, awarded to the University of Sydney, the Australian National University, Swinburne University of Technology, the University of Queensland, the University of Western Australia, the University of Melbourne, Curtin University of Technology, Monash University, and the Australian Astronomical Observatory. SkyMapper is owned and operated by The Australian National University’s Research School of Astronomy and Astrophysics. The survey data were processed and provided by the SkyMapper Team at ANU. The SkyMapper node of the All-Sky Virtual Observatory (ASVO) is hosted at the National Computational Infrastructure (NCI). Development and support of the SkyMapper node of the ASVO has been funded in part by Astronomy Australia Limited (AAL) and the Australian Government through the Commonwealth’s Education Investment Fund (EIF) and National Collaborative Research Infrastructure Strategy (NCRIS), particularly the National eResearch Collaboration Tools and Resources (NeCTAR) and the Australian National Data Service Projects (ANDS).\r\n\r\nThe National Radio Astronomy Observatory (NRAO) is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc. We thank the NRAO for carrying out the Karl G. Jansky VLA observation.\r\n\r\nNote Added - Shortly before this work was accepted, we became aware of a later preprint by K. Patra et al. (2026). The work reaches many similar conclusions to our own, and presents additional JWST data of TDE 2025abcr. We also thank the authors for highlighting a typo on an earlier version of this manuscript, with the projected offset incorrectly given as 10.3 kpc rather than 9.3 kpc.\r\n\r\nFacilities: PO:1.2m - Palomar Observatory's 1.2 meter Samuel Oschin Telescope (ZTF), Hale - Palomar Observatory's 5.1m Hale Telescope (protoCerberus), Keck:I - KECK I Telescope (LRIS), LDT - (DeVeney, LMI), NOT - Nordic Optical Telescope (ALFOSC), PO:1.5m - Palomar Observatory's 1.5 meter Telescope (SEDM), SOAR - The Southern Astrophysical Research Telescope (Goodman), Swift - Swift Gamma-Ray Burst Mission (XRT, UVOT) - , VLA - Very Large Array, WO:2m - (3KK).\r\n\r\nSoftware: astroquery (B. D. Johnson et al. 2021), emcee (D. Foreman-Mackey et al. 2013), HEASoft, galsynthspec (R. D. Stein 2025), mirar (R. D. Stein et al. 2025), prospector (B. D. Johnson et al. 2021), SCAMP (E. Bertin 2006), scarlet (P. Melchior et al. 2018), Source Extractor (E. Bertin & S. Arnouts 1996), swifttools, tdescore (R. Stein et al. 2024), uvotredux (R. D. Stein & J. Carney 2025)." article_number: L57 article_processing_charge: Yes article_type: original arxiv: 1 author: - first_name: Robert full_name: Stein, Robert last_name: Stein - first_name: Jonathan full_name: Carney, Jonathan last_name: Carney - first_name: Charlotte full_name: Ward, Charlotte last_name: Ward - first_name: Raffaella full_name: Margutti, Raffaella last_name: Margutti - first_name: Xander J. full_name: Hall, Xander J. last_name: Hall - first_name: Itai full_name: Sfaradi, Itai last_name: Sfaradi - first_name: Igor full_name: Andreoni, Igor last_name: Andreoni - first_name: Panos full_name: Charalampopoulos, Panos last_name: Charalampopoulos - first_name: Ryan full_name: Chornock, Ryan last_name: Chornock - first_name: Suvi full_name: Gezari, Suvi last_name: Gezari - first_name: Geoffrey full_name: Mo, Geoffrey last_name: Mo - first_name: Yuhan full_name: Yao, Yuhan last_name: Yao - first_name: Akash full_name: Anumarlapudi, Akash last_name: Anumarlapudi - first_name: Eric C. full_name: Bellm, Eric C. last_name: Bellm - first_name: Joshua S. full_name: Bloom, Joshua S. last_name: Bloom - first_name: Malte full_name: Busmann, Malte last_name: Busmann - first_name: Ilaria full_name: Caiazzo, Ilaria id: 8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d last_name: Caiazzo orcid: 0000-0002-4770-5388 - first_name: S. Bradley full_name: Cenko, S. Bradley last_name: Cenko - first_name: Matthew J. full_name: Graham, Matthew J. last_name: Graham - first_name: Steven L. full_name: Groom, Steven L. last_name: Groom - first_name: Daniel full_name: Gruen, Daniel last_name: Gruen - first_name: Erica full_name: Hammerstein, Erica last_name: Hammerstein - first_name: Benjamin C. full_name: Kaiser, Benjamin C. last_name: Kaiser - first_name: Mansi M. full_name: Kasliwal, Mansi M. last_name: Kasliwal - first_name: Brendan full_name: O’Connor, Brendan last_name: O’Connor - first_name: Antonella full_name: Palmese, Antonella last_name: Palmese - first_name: Josiah full_name: Purdum, Josiah last_name: Purdum - first_name: Jillian C. full_name: Rastinejad, Jillian C. last_name: Rastinejad - first_name: Reed full_name: Riddle, Reed last_name: Riddle - first_name: Ben full_name: Rusholme, Ben last_name: Rusholme - first_name: Jesper full_name: Sollerman, Jesper last_name: Sollerman - first_name: Jean J. full_name: Somalwar, Jean J. last_name: Somalwar - first_name: Sylvain full_name: Veilleux, Sylvain last_name: Veilleux citation: ama: 'Stein R, Carney J, Ward C, et al. TDE 2025abcr: A tidal disruption event in the outskirts of a massive galaxy. The Astrophysical Journal Letters. 2026;1006(2). doi:10.3847/2041-8213/ae77f3' apa: 'Stein, R., Carney, J., Ward, C., Margutti, R., Hall, X. J., Sfaradi, I., … Veilleux, S. (2026). TDE 2025abcr: A tidal disruption event in the outskirts of a massive galaxy. The Astrophysical Journal Letters. IOP Publishing. https://doi.org/10.3847/2041-8213/ae77f3' chicago: 'Stein, Robert, Jonathan Carney, Charlotte Ward, Raffaella Margutti, Xander J. Hall, Itai Sfaradi, Igor Andreoni, et al. “TDE 2025abcr: A Tidal Disruption Event in the Outskirts of a Massive Galaxy.” The Astrophysical Journal Letters. IOP Publishing, 2026. https://doi.org/10.3847/2041-8213/ae77f3.' ieee: 'R. Stein et al., “TDE 2025abcr: A tidal disruption event in the outskirts of a massive galaxy,” The Astrophysical Journal Letters, vol. 1006, no. 2. IOP Publishing, 2026.' ista: 'Stein R, Carney J, Ward C, Margutti R, Hall XJ, Sfaradi I, Andreoni I, Charalampopoulos P, Chornock R, Gezari S, Mo G, Yao Y, Anumarlapudi A, Bellm EC, Bloom JS, Busmann M, Caiazzo I, Cenko SB, Graham MJ, Groom SL, Gruen D, Hammerstein E, Kaiser BC, Kasliwal MM, O’Connor B, Palmese A, Purdum J, Rastinejad JC, Riddle R, Rusholme B, Sollerman J, Somalwar JJ, Veilleux S. 2026. TDE 2025abcr: A tidal disruption event in the outskirts of a massive galaxy. The Astrophysical Journal Letters. 1006(2), L57.' mla: 'Stein, Robert, et al. “TDE 2025abcr: A Tidal Disruption Event in the Outskirts of a Massive Galaxy.” The Astrophysical Journal Letters, vol. 1006, no. 2, L57, IOP Publishing, 2026, doi:10.3847/2041-8213/ae77f3.' short: R. Stein, J. Carney, C. Ward, R. Margutti, X.J. Hall, I. Sfaradi, I. Andreoni, P. Charalampopoulos, R. Chornock, S. Gezari, G. Mo, Y. Yao, A. Anumarlapudi, E.C. Bellm, J.S. Bloom, M. Busmann, I. Caiazzo, S.B. Cenko, M.J. Graham, S.L. Groom, D. Gruen, E. Hammerstein, B.C. Kaiser, M.M. Kasliwal, B. O’Connor, A. Palmese, J. Purdum, J.C. Rastinejad, R. Riddle, B. Rusholme, J. Sollerman, J.J. Somalwar, S. Veilleux, The Astrophysical Journal Letters 1006 (2026). das_tickbox: '0' date_created: 2026-08-11T06:19:19Z date_published: 2026-07-27T00:00:00Z date_updated: 2026-08-11T07:45:27Z day: '27' ddc: - '520' department: - _id: IlCa doi: 10.3847/2041-8213/ae77f3 external_id: arxiv: - '2602.10180' file: - access_level: open_access checksum: 42b983f18497bb644f422709de7dc68c content_type: application/pdf creator: dernst date_created: 2026-08-11T07:45:16Z date_updated: 2026-08-11T07:45:16Z file_id: '22682' file_name: 2026_AstrophysicalJourLetters_Stein.pdf file_size: 10322417 relation: main_file success: 1 file_date_updated: 2026-08-11T07:45:16Z fulldoi: https://doi.org/10.3847/2041-8213/ae77f3 has_accepted_license: '1' intvolume: ' 1006' issue: '2' language: - iso: eng month: '07' oa: 1 oa_version: Published Version publication: The Astrophysical Journal Letters publication_identifier: eissn: - 2041-8213 issn: - 2041-8205 publication_status: published publisher: IOP Publishing quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: yes title: 'TDE 2025abcr: A tidal disruption event in the outskirts of a massive galaxy' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 1006 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '22674' abstract: - lang: eng text: "Identification of the genomic regions that contribute to reproductive isolation and how\r\nthey interact is a major goal of evolutionary genetics. Much effort has focused on\r\nlocating candidate genes and potential barrier loci by scanning genomes for regions\r\nof excess differentiation (FST). An alternative, and perhaps more robust approach, is\r\nto scan for genomic regions exhibiting steep clines in allele frequency across a hybrid\r\nzone. We develop a computationally efficient method for approximating cline parameters\r\nfor large number of loci, and apply it to genomic data from across a hybrid zone\r\nbetween flower colour varieties of Antirrhinum majus (A. m. m var. pseudomajus and\r\nA. m. m var. striatum). Most steep clines are clustered in seven genomic regions,\r\nonly four of which were present from FST scans between all pair-wise comparisons.\r\nSix of these regions carry previously identified loci that influence flower colour in the\r\nhybrid zone. The seventh region harbours a novel locus, RUBIA, modifying magenta\r\nintensity. Clines at RUBIA approached fixation on the magenta side of the hybrid\r\nzone, whilst remaining polymorphic on the yellow side. This polymorphism on the\r\nyellow side may reflect a smaller phenotypic effect of RUBIA in yellow compared\r\nto magenta genetic backgrounds. Our findings illustrate how whole-genome cline\r\nscans in hybrid zones can robustly detect genomic regions contributing to phenotypic\r\ndifferences and highlight how different reproductive barrier loci interact across the\r\ngenome." acknowledgement: This work was supported by the Biotechnology and Biological Sciences Research Council (https://www.ukri.org/councils/bbsrc/) (grants BB/S009256/1, BB/G009325/1, BBS/E/JI/230002C, and BBS/E/J/000PR9773 to EC, and Norwich Research Park Biosciences Doctoral Training Partnership grant (https://www.jic.ac.uk/training-careers/postgraduate-opportunities/nrp-doctoral-training-partnership/) (BB/M011216/1 to DR) and European Research Council (https://erc.europa.eu/homepage) ERC Advanced Grant HaplotypeStructure (101055327 to NB). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We are grateful to Monique Burrus, Christophe Andalo, Tom Ellis, Parvathy Surendranadh and members of the Barton group for interesting discussion. We are also grateful for numerous undergraduate volunteers who assisted with collecting of flowers and leaf samples in the field. Melinda Pickup passed away before the submission of the final version of this manuscript. David L Field accepts responsibility for the integrity and validity of the data collected and analyzed. article_number: e1012173 article_processing_charge: Yes article_type: original author: - first_name: David full_name: Field, David id: 419049E2-F248-11E8-B48F-1D18A9856A87 last_name: Field orcid: 0000-0002-4014-8478 - first_name: Sean full_name: Stankowski, Sean id: 43161670-5719-11EA-8025-FABC3DDC885E last_name: Stankowski - first_name: Taylor full_name: Reiter, Taylor last_name: Reiter - first_name: Jitka full_name: Polechova, Jitka last_name: Polechova - first_name: Desmond full_name: Bradley, Desmond last_name: Bradley - first_name: Daniel M. full_name: Richardson, Daniel M. last_name: Richardson - first_name: Annabel full_name: Whibley, Annabel last_name: Whibley - first_name: Arka full_name: Pal, Arka id: 6AAB2240-CA9A-11E9-9C1A-D9D1E5697425 last_name: Pal orcid: 0000-0002-4530-8469 - first_name: Daria full_name: Shipilina, Daria id: 428A94B0-F248-11E8-B48F-1D18A9856A87 last_name: Shipilina orcid: 0000-0002-1145-9226 - first_name: Louis full_name: Boell, Louis last_name: Boell - first_name: Melinda full_name: Pickup, Melinda id: 2C78037E-F248-11E8-B48F-1D18A9856A87 last_name: Pickup orcid: 0000-0001-6118-0541 - first_name: Yongbiao full_name: Xue, Yongbiao last_name: Xue - first_name: Enrico full_name: Coen, Enrico last_name: Coen - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 biorxivid: 1 citation: ama: Field D, Stankowski S, Reiter T, et al. Genome-wide cline analysis identifies new locus contributing to a barrier to gene flow across an Antirrhinum hybrid zone. PLOS Genetics. 2026;22(7). doi:10.1371/journal.pgen.1012173 apa: Field, D., Stankowski, S., Reiter, T., Polechova, J., Bradley, D., Richardson, D. M., … Barton, N. H. (2026). Genome-wide cline analysis identifies new locus contributing to a barrier to gene flow across an Antirrhinum hybrid zone. PLOS Genetics. Public Library of Science. https://doi.org/10.1371/journal.pgen.1012173 chicago: Field, David, Sean Stankowski, Taylor Reiter, Jitka Polechova, Desmond Bradley, Daniel M. Richardson, Annabel Whibley, et al. “Genome-Wide Cline Analysis Identifies New Locus Contributing to a Barrier to Gene Flow across an Antirrhinum Hybrid Zone.” PLOS Genetics. Public Library of Science, 2026. https://doi.org/10.1371/journal.pgen.1012173. ieee: D. Field et al., “Genome-wide cline analysis identifies new locus contributing to a barrier to gene flow across an Antirrhinum hybrid zone,” PLOS Genetics, vol. 22, no. 7. Public Library of Science, 2026. ista: Field D, Stankowski S, Reiter T, Polechova J, Bradley D, Richardson DM, Whibley A, Pal A, Shipilina D, Boell L, Pickup M, Xue Y, Coen E, Barton NH. 2026. Genome-wide cline analysis identifies new locus contributing to a barrier to gene flow across an Antirrhinum hybrid zone. PLOS Genetics. 22(7), e1012173. mla: Field, David, et al. “Genome-Wide Cline Analysis Identifies New Locus Contributing to a Barrier to Gene Flow across an Antirrhinum Hybrid Zone.” PLOS Genetics, vol. 22, no. 7, e1012173, Public Library of Science, 2026, doi:10.1371/journal.pgen.1012173. short: D. Field, S. Stankowski, T. Reiter, J. Polechova, D. Bradley, D.M. Richardson, A. Whibley, A. Pal, D. Shipilina, L. Boell, M. Pickup, Y. Xue, E. Coen, N.H. Barton, PLOS Genetics 22 (2026). corr_author: '1' das_tickbox: '1' dataavailabilitystatement: 'The raw DNA poolSeq data and RNA data have been uploaded to SRA under accession number PRJNA1232105. The A. m. m. var. pseudo majus assembly and GFF annotations have been uploaded to NCBI WGS under accession number PRJNA1232105. The A. majus reference genome V3.0 is available at the NGDC Genome Warehouse under accession number GWHBJVT00000000. The SNP KASP data and flower colour phenotyping is available on Dryad at DOI: https://doi.org/10.5061/dryad.3bk3j9kx2. The FastClines script is available at https://github.com/dfield007/fastClines, slidingWindow genome scans at https://github.com/dfield007/slidingWindows, and all other scripts for analyses and generating figures available at https://github.com/dfield007/genome_wide_clines].' date_created: 2026-08-11T06:19:05Z date_published: 2026-07-13T00:00:00Z date_updated: 2026-08-11T07:55:22Z day: '13' ddc: - '570' department: - _id: NiBa doi: 10.1371/journal.pgen.1012173 external_id: biorxivid: - 10.1101/2025.02.17.638607 pmid: - '42441626' file: - access_level: open_access checksum: 3e2d3acc179f4672c49217ae4a6e237c content_type: application/pdf creator: dernst date_created: 2026-08-11T07:53:14Z date_updated: 2026-08-11T07:53:14Z file_id: '22683' file_name: 2026_PloSGenetics_Field.pdf file_size: 2462781 relation: main_file success: 1 file_date_updated: 2026-08-11T07:53:14Z fulldoi: https://doi.org/10.1371/journal.pgen.1012173 has_accepted_license: '1' intvolume: ' 22' issue: '7' language: - iso: eng month: '07' oa: 1 oa_version: Published Version pmid: 1 project: - _id: bd6958e0-d553-11ed-ba76-86eba6a76c00 grant_number: '101055327' name: Understanding the evolution of continuous genomes publication: PLOS Genetics publication_identifier: eissn: - 1553-7404 publication_status: published publisher: Public Library of Science quality_controlled: '1' researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: yes title: Genome-wide cline analysis identifies new locus contributing to a barrier to gene flow across an Antirrhinum hybrid zone tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 22 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '22676' abstract: - lang: eng text: 'We search for a population-level signature of gravitational-wave recoiling supermassive black holes: a positive correlation between dust obscuration and the magnitude of the line-of-sight velocity offset of broad emission lines relative to the host. Using the SDSS DR16 quasar catalogue, we estimate the velocity offset, $\Delta v$, as the difference between the broad H$\beta$ redshift and a noise-weighted redshift from narrow lines ([O iii] 5007, [O ii] 3728, and Ca ii 3934). We adopt the redshift-relative colour excess $\Delta (g-i)$ as a proxy for dust column density. Analysing $\sim 10^{5}$ quasars that meet basic spectral quality requirements, we find a modest but highly significant positive correlation between $|\Delta v|$ and $\Delta (g-i)$ (Spearman $r\simeq 0.12$ and Pearson $r\simeq 0.13$, with $p\ll 10^{-10}$ in both cases). The fraction of highly obscured quasars increases with $|\Delta v|$, indicating that the correlation is driven by a dust-reddened subpopulation. The result is robust to the choice of minimum $|\Delta v|$ threshold and to the line redshift estimator (peak vs. centroid). As expected, the correlation is largely absent when velocity offsets are computed between narrow emission lines. We find systematic differences between redshifted and blueshifted subsamples, which may point to residual velocity biases or additional physical effects (e.g. winds, inflows, orientation-dependent obscuration, or asymmetric broad-line regions). Recoiling massive black holes provide a natural explanation for the observed correlation, but alternative scenarios should be explored. If confirmed, this would enable population-level constraints on massive black hole merger rates, recoil dynamics, and active galactic nuclei disc properties.' acknowledgement: We thank Paul Hewett for useful discussions, and Qiaoya Wu for guidance on the data presented in Q. Wu & Y. Shen (2022). ZH acknowledges financial support from NASA grants 80NSSC24K0440 and 80NSSC22K0822. PR and ZF have received funding from the HUN-REN Hungarian Research Network and were supported by the NKFIH excellence grant TKP2021-NKTA-64. article_number: stag1367 article_processing_charge: Yes article_type: original arxiv: 1 author: - first_name: Bence full_name: Bécsy, Bence last_name: Bécsy - first_name: Peter full_name: Raffai, Peter last_name: Raffai - first_name: Zoltán full_name: Haiman, Zoltán id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36 last_name: Haiman orcid: 0000-0003-3633-5403 - first_name: Andor full_name: Budai, Andor last_name: Budai - first_name: Zsolt full_name: Frei, Zsolt last_name: Frei citation: ama: Bécsy B, Raffai P, Haiman Z, Budai A, Frei Z. Statistical evidence for massive black hole recoils in active galactic nuclei. Monthly Notices of the Royal Astronomical Society. 2026;550(4). doi:10.1093/mnras/stag1367 apa: Bécsy, B., Raffai, P., Haiman, Z., Budai, A., & Frei, Z. (2026). Statistical evidence for massive black hole recoils in active galactic nuclei. Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/stag1367 chicago: Bécsy, Bence, Peter Raffai, Zoltán Haiman, Andor Budai, and Zsolt Frei. “Statistical Evidence for Massive Black Hole Recoils in Active Galactic Nuclei.” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2026. https://doi.org/10.1093/mnras/stag1367. ieee: B. Bécsy, P. Raffai, Z. Haiman, A. Budai, and Z. Frei, “Statistical evidence for massive black hole recoils in active galactic nuclei,” Monthly Notices of the Royal Astronomical Society, vol. 550, no. 4. Oxford University Press, 2026. ista: Bécsy B, Raffai P, Haiman Z, Budai A, Frei Z. 2026. Statistical evidence for massive black hole recoils in active galactic nuclei. Monthly Notices of the Royal Astronomical Society. 550(4), stag1367. mla: Bécsy, Bence, et al. “Statistical Evidence for Massive Black Hole Recoils in Active Galactic Nuclei.” Monthly Notices of the Royal Astronomical Society, vol. 550, no. 4, stag1367, Oxford University Press, 2026, doi:10.1093/mnras/stag1367. short: B. Bécsy, P. Raffai, Z. Haiman, A. Budai, Z. Frei, Monthly Notices of the Royal Astronomical Society 550 (2026). das_tickbox: '1' dataavailabilitystatement: The data and software that support the findings of this study are openly available. The processed data sets, analysis outputs, and software are archived on Zenodo (B. Bécsy et al. 2026a), and are also available on GitHub (B. Bécsy et al. 2026b). date_created: 2026-08-11T06:19:34Z date_published: 2026-08-01T00:00:00Z date_updated: 2026-08-11T06:55:10Z day: '01' ddc: - '520' department: - _id: ZoHa doi: 10.1093/mnras/stag1367 external_id: arxiv: - '2605.04781' file: - access_level: open_access checksum: 85a01a4e163e4d2eccebe2472cdb453f content_type: application/pdf creator: dernst date_created: 2026-08-11T06:53:09Z date_updated: 2026-08-11T06:53:09Z file_id: '22681' file_name: 2026_MNRAS_Becsy.pdf file_size: 3792460 relation: main_file success: 1 file_date_updated: 2026-08-11T06:53:09Z fulldoi: https://doi.org/10.1093/mnras/stag1367 has_accepted_license: '1' intvolume: ' 550' issue: '4' language: - iso: eng month: '08' oa: 1 oa_version: Published Version publication: Monthly Notices of the Royal Astronomical Society publication_identifier: eissn: - 1365-2966 issn: - 0035-8711 publication_status: published publisher: Oxford University Press quality_controlled: '1' researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: no title: Statistical evidence for massive black hole recoils in active galactic nuclei tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 550 year: '2026' ... --- OA_place: publisher _id: '22626' acknowledgement: 'This thesis and the publications within, were financially supported by the Institute of Science and Technology Austria and the Werner Siemens Foundation under the project “High Thermoelectric Materials: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery”.' alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Christine full_name: Fiedler, Christine id: bd3fceba-dc74-11ea-a0a7-c17f71817366 last_name: Fiedler citation: ama: Fiedler C. Mechanistic insight into solution-processed p-type tin chalcogenides as a basis for designing their n-type analogs. 2026. doi:10.15479/AT-ISTA-22626 apa: Fiedler, C. (2026). Mechanistic insight into solution-processed p-type tin chalcogenides as a basis for designing their n-type analogs. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-22626 chicago: Fiedler, Christine. “Mechanistic Insight into Solution-Processed p-Type Tin Chalcogenides as a Basis for Designing Their n-Type Analogs.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-22626. ieee: C. Fiedler, “Mechanistic insight into solution-processed p-type tin chalcogenides as a basis for designing their n-type analogs,” Institute of Science and Technology Austria, 2026. ista: Fiedler C. 2026. Mechanistic insight into solution-processed p-type tin chalcogenides as a basis for designing their n-type analogs. Institute of Science and Technology Austria. mla: Fiedler, Christine. Mechanistic Insight into Solution-Processed p-Type Tin Chalcogenides as a Basis for Designing Their n-Type Analogs. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-22626. short: C. Fiedler, Mechanistic Insight into Solution-Processed p-Type Tin Chalcogenides as a Basis for Designing Their n-Type Analogs, Institute of Science and Technology Austria, 2026. corr_author: '1' date_created: 2026-08-03T07:55:16Z date_published: 2026-08-05T00:00:00Z date_updated: 2026-08-11T12:39:15Z day: '05' ddc: - '540' - '546' - '530' degree_awarded: PhD department: - _id: GradSch - _id: MaIb doi: 10.15479/AT-ISTA-22626 doi_confirm: '1' file: - access_level: closed checksum: 4f357f3c0f5ee3d679dd0395dbafc4bb content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: cfiedler date_created: 2026-08-07T09:10:56Z date_updated: 2026-08-07T10:02:41Z file_id: '22659' file_name: 2026_Fiedler_Christine_Thesis.docx file_size: 625541367 relation: source_file - access_level: closed checksum: 69784d2e7b9ef3d3a0fbe134f3bba089 content_type: application/pdf creator: cfiedler date_created: 2026-08-07T09:10:45Z date_updated: 2026-08-07T10:16:07Z embargo: 2027-02-07 embargo_to: open_access file_id: '22660' file_name: 2026_Fiedler_Christine_Thesis.pdf file_size: 16646551 relation: main_file file_date_updated: 2026-08-07T10:16:07Z fulldoi: https://doi.org/10.15479/AT-ISTA-22626 has_accepted_license: '1' language: - iso: eng month: '08' oa_version: Published Version page: '141' project: - _id: 9B8F7476-BA93-11EA-9121-9846C619BF3A name: 'HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery' publication_identifier: isbn: - 978-3-99078-086-2 issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '12237' relation: part_of_dissertation status: public - id: '17124' relation: part_of_dissertation status: public - id: '17052' relation: part_of_dissertation status: public status: public supervisor: - first_name: Maria full_name: Ibáñez, Maria id: 43C61214-F248-11E8-B48F-1D18A9856A87 last_name: Ibáñez orcid: 0000-0001-5013-2843 title: Mechanistic insight into solution-processed p-type tin chalcogenides as a basis for designing their n-type analogs tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: dissertation user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2026' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '22228' abstract: - lang: eng text: "In a mixed generalized linear model, the goal is to learn multiple signals from unlabeled observations: each sample comes from exactly one signal, but it is not known which one. We consider the prototypical problem of estimating two statistically independent signals in a mixed generalized linear model with Gaussian covariates. Spectral methods are a popular class of estimators which output the top two eigenvectors of a suitable data-dependent matrix. However, despite the wide applicability, their design is still obtained via heuristic considerations, and the number of samples \U0001D45B needed to guarantee recovery is superlinear in the signal dimension \U0001D451. In this paper, we develop exact asymptotics on spectral methods in the challenging proportional regime in which \U0001D45B,\U0001D451 grow large and their ratio converges to a finite constant. This allows us optimize the design of the spectral method, and combine it with a simple linear estimator, to minimize the estimation error. Our characterization exploits a mix of tools from random matrices, free probability, and the theory of approximate message passing algorithms. Numerical simulations for mixed linear regression and phase retrieval demonstrate the advantage enabled by our analysis over existing designs of spectral methods." acknowledgement: The first and second authors were partially supported by the 2019 Lopez-Loreta prize. article_processing_charge: Yes (in subscription journal) article_type: original arxiv: 1 author: - first_name: Yihan full_name: Zhang, Yihan last_name: Zhang - first_name: Marco full_name: Mondelli, Marco id: 27EB676C-8706-11E9-9510-7717E6697425 last_name: Mondelli orcid: 0000-0002-3242-7020 - first_name: Ramji full_name: Venkataramanan, Ramji last_name: Venkataramanan citation: ama: Zhang Y, Mondelli M, Venkataramanan R. Precise asymptotics for spectral methods in mixed generalized linear models. SIAM Journal on Mathematics of Data Science. 2026;8(2):411-439. doi:10.1137/24m1702854 apa: Zhang, Y., Mondelli, M., & Venkataramanan, R. (2026). Precise asymptotics for spectral methods in mixed generalized linear models. SIAM Journal on Mathematics of Data Science. SIAM. https://doi.org/10.1137/24m1702854 chicago: Zhang, Yihan, Marco Mondelli, and Ramji Venkataramanan. “Precise Asymptotics for Spectral Methods in Mixed Generalized Linear Models.” SIAM Journal on Mathematics of Data Science. SIAM, 2026. https://doi.org/10.1137/24m1702854. ieee: Y. Zhang, M. Mondelli, and R. Venkataramanan, “Precise asymptotics for spectral methods in mixed generalized linear models,” SIAM Journal on Mathematics of Data Science, vol. 8, no. 2. SIAM, pp. 411–439, 2026. ista: Zhang Y, Mondelli M, Venkataramanan R. 2026. Precise asymptotics for spectral methods in mixed generalized linear models. SIAM Journal on Mathematics of Data Science. 8(2), 411–439. mla: Zhang, Yihan, et al. “Precise Asymptotics for Spectral Methods in Mixed Generalized Linear Models.” SIAM Journal on Mathematics of Data Science, vol. 8, no. 2, SIAM, 2026, pp. 411–39, doi:10.1137/24m1702854. short: Y. Zhang, M. Mondelli, R. Venkataramanan, SIAM Journal on Mathematics of Data Science 8 (2026) 411–439. corr_author: '1' das_tickbox: '0' date_created: 2026-06-30T13:03:41Z date_published: 2026-06-01T00:00:00Z date_updated: 2026-08-12T06:23:07Z day: '01' ddc: - '000' department: - _id: MaMo doi: 10.1137/24m1702854 external_id: arxiv: - '2211.11368' file: - access_level: open_access checksum: 5cfd350dc64d1476063e959316dbff65 content_type: application/pdf creator: dernst date_created: 2026-07-01T06:22:15Z date_updated: 2026-07-01T06:22:15Z file_id: '22230' file_name: 2026_SIAMJourmathDataScience_Zhang.pdf file_size: 1210346 relation: main_file success: 1 file_date_updated: 2026-07-01T06:22:15Z fulldoi: https://doi.org/10.1137/24m1702854 has_accepted_license: '1' intvolume: ' 8' issue: '2' keyword: - spectral estimator - generalized linear models - mixed regression - high-dimensional asymptotics - random matrix theory - approximate message passing (AMP) language: - iso: eng mathsc: - '62E20' - 62J05 - 62J12 month: '06' oa: 1 oa_version: Published Version page: 411-439 project: - _id: 059876FA-7A3F-11EA-A408-12923DDC885E name: Prix Lopez-Loretta 2019 - Marco Mondelli publication: SIAM Journal on Mathematics of Data Science publication_identifier: eissn: - 2577-0187 publication_status: published publisher: SIAM quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: no title: Precise asymptotics for spectral methods in mixed generalized linear models tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 8 year: '2026' ...