---
_id: '8744'
abstract:
- lang: eng
text: Understanding the conformational sampling of translation-arrested ribosome
nascent chain complexes is key to understand co-translational folding. Up to now,
coupling of cysteine oxidation, disulfide bond formation and structure formation
in nascent chains has remained elusive. Here, we investigate the eye-lens protein
γB-crystallin in the ribosomal exit tunnel. Using mass spectrometry, theoretical
simulations, dynamic nuclear polarization-enhanced solid-state nuclear magnetic
resonance and cryo-electron microscopy, we show that thiol groups of cysteine
residues undergo S-glutathionylation and S-nitrosylation and form non-native disulfide
bonds. Thus, covalent modification chemistry occurs already prior to nascent chain
release as the ribosome exit tunnel provides sufficient space even for disulfide
bond formation which can guide protein folding.
acknowledgement: 'We acknowledge help from Anja Seybert, Margot Frangakis, Diana Grewe,
Mikhail Eltsov, Utz Ermel, and Shintaro Aibara. The work was supported by Deutsche
Forschungsgemeinschaft in the CLiC graduate school. Work at the Center for Biomolecular
Magnetic Resonance (BMRZ) is supported by the German state of Hesse. The work at
BMRZ has been supported by the state of Hesse. L.S. has been supported by the DFG
graduate college: CLiC.'
article_number: '5569'
article_processing_charge: No
article_type: original
author:
- first_name: Linda
full_name: Schulte, Linda
last_name: Schulte
- first_name: Jiafei
full_name: Mao, Jiafei
last_name: Mao
- first_name: Julian
full_name: Reitz, Julian
last_name: Reitz
- first_name: Sridhar
full_name: Sreeramulu, Sridhar
last_name: Sreeramulu
- first_name: Denis
full_name: Kudlinzki, Denis
last_name: Kudlinzki
- first_name: Victor-Valentin
full_name: Hodirnau, Victor-Valentin
id: 3661B498-F248-11E8-B48F-1D18A9856A87
last_name: Hodirnau
orcid: 0000-0003-3904-947X
- first_name: Jakob
full_name: Meier-Credo, Jakob
last_name: Meier-Credo
- first_name: Krishna
full_name: Saxena, Krishna
last_name: Saxena
- first_name: Florian
full_name: Buhr, Florian
last_name: Buhr
- first_name: Julian D.
full_name: Langer, Julian D.
last_name: Langer
- first_name: Martin
full_name: Blackledge, Martin
last_name: Blackledge
- first_name: Achilleas S.
full_name: Frangakis, Achilleas S.
last_name: Frangakis
- first_name: Clemens
full_name: Glaubitz, Clemens
last_name: Glaubitz
- first_name: Harald
full_name: Schwalbe, Harald
last_name: Schwalbe
citation:
ama: Schulte L, Mao J, Reitz J, et al. Cysteine oxidation and disulfide formation
in the ribosomal exit tunnel. Nature Communications. 2020;11. doi:10.1038/s41467-020-19372-x
apa: Schulte, L., Mao, J., Reitz, J., Sreeramulu, S., Kudlinzki, D., Hodirnau, V.-V.,
… Schwalbe, H. (2020). Cysteine oxidation and disulfide formation in the ribosomal
exit tunnel. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-020-19372-x
chicago: Schulte, Linda, Jiafei Mao, Julian Reitz, Sridhar Sreeramulu, Denis Kudlinzki,
Victor-Valentin Hodirnau, Jakob Meier-Credo, et al. “Cysteine Oxidation and Disulfide
Formation in the Ribosomal Exit Tunnel.” Nature Communications. Springer
Nature, 2020. https://doi.org/10.1038/s41467-020-19372-x.
ieee: L. Schulte et al., “Cysteine oxidation and disulfide formation in the
ribosomal exit tunnel,” Nature Communications, vol. 11. Springer Nature,
2020.
ista: Schulte L, Mao J, Reitz J, Sreeramulu S, Kudlinzki D, Hodirnau V-V, Meier-Credo
J, Saxena K, Buhr F, Langer JD, Blackledge M, Frangakis AS, Glaubitz C, Schwalbe
H. 2020. Cysteine oxidation and disulfide formation in the ribosomal exit tunnel.
Nature Communications. 11, 5569.
mla: Schulte, Linda, et al. “Cysteine Oxidation and Disulfide Formation in the Ribosomal
Exit Tunnel.” Nature Communications, vol. 11, 5569, Springer Nature, 2020,
doi:10.1038/s41467-020-19372-x.
short: L. Schulte, J. Mao, J. Reitz, S. Sreeramulu, D. Kudlinzki, V.-V. Hodirnau,
J. Meier-Credo, K. Saxena, F. Buhr, J.D. Langer, M. Blackledge, A.S. Frangakis,
C. Glaubitz, H. Schwalbe, Nature Communications 11 (2020).
date_created: 2020-11-09T07:49:36Z
date_published: 2020-11-04T00:00:00Z
date_updated: 2025-06-12T07:01:22Z
day: '04'
ddc:
- '570'
department:
- _id: EM-Fac
doi: 10.1038/s41467-020-19372-x
external_id:
isi:
- '000592028600001'
pmid:
- '33149120'
file:
- access_level: open_access
checksum: b2688f0347e69e6629bba582077278c5
content_type: application/pdf
creator: dernst
date_created: 2020-11-09T07:56:24Z
date_updated: 2020-11-09T07:56:24Z
file_id: '8745'
file_name: 2020_NatureComm_Schulte.pdf
file_size: 1670898
relation: main_file
success: 1
file_date_updated: 2020-11-09T07:56:24Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
keyword:
- General Biochemistry
- Genetics and Molecular Biology
- General Physics and Astronomy
- General Chemistry
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
issn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cysteine oxidation and disulfide formation in the ribosomal exit tunnel
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2020'
...
---
_id: '8746'
abstract:
- lang: eng
text: "Research in the field of colloidal semiconductor nanocrystals (NCs) has progressed
tremendously, mostly because of their exceptional optoelectronic properties. Core@shell
NCs, in which one or more inorganic layers overcoat individual NCs, recently received
significant attention due to their remarkable optical characteristics. Reduced
Auger recombination, suppressed blinking, and enhanced carrier multiplication
are among the merits of core@shell NCs. Despite their importance in device development,
the influence of the shell and the surface modification of the core@shell NC assemblies
on the charge carrier transport remains a pertinent research objective. Type-II
PbTe@PbS core@shell NCs, in which exclusive electron transport was demonstrated,
still exhibit instability of their electron \r\n ransport. Here, we demonstrate
the enhancement of electron transport and stability in PbTe@PbS core@shell NC
assemblies using iodide as a surface passivating ligand. The combination of the
PbS shelling and the use of the iodide ligand contributes to the addition of one
mobile electron for each core@shell NC. Furthermore, both electron mobility and
on/off current modulation ratio values of the core@shell NC field-effect transistor
are steady with the usage of iodide. Excellent stability in these exclusively
electron-transporting core@shell NCs paves the way for their utilization in electronic
devices. "
acknowledgement: "This work was partly supported by Grants-in-Aid for Scientific Research
by Young Scientist A (KAKENHI Wakate-A) No.\r\nJP17H04802, Grants-in-Aid for Scientific
Research No. JP19H05602 from the Japan Society for the Promotion of Science, and
RIKEN Incentive Research Grant (Shoreikadai) 2016. M.V.K. and M.I. acknowledge financial
support from the European Union (EU) via FP7 ERC Starting Grant 2012 (Project NANOSOLID,
GA No. 306733) and ETH Zurich via ETH career seed grant (No. SEED-18 16-2). We acknowledge
Mrs. T. Kikitsu and Dr. D. Hashizume (RIKEN-CEMS) for access to the transmission
electron microscope facility."
article_number: '173101'
article_processing_charge: No
article_type: original
author:
- first_name: Retno
full_name: Miranti, Retno
last_name: Miranti
- first_name: Ricky Dwi
full_name: Septianto, Ricky Dwi
last_name: Septianto
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
- first_name: Maksym V.
full_name: Kovalenko, Maksym V.
last_name: Kovalenko
- first_name: Nobuhiro
full_name: Matsushita, Nobuhiro
last_name: Matsushita
- first_name: Yoshihiro
full_name: Iwasa, Yoshihiro
last_name: Iwasa
- first_name: Satria Zulkarnaen
full_name: Bisri, Satria Zulkarnaen
last_name: Bisri
citation:
ama: Miranti R, Septianto RD, Ibáñez M, et al. Electron transport in iodide-capped
core@shell PbTe@PbS colloidal nanocrystal solids. Applied Physics Letters.
2020;117(17). doi:10.1063/5.0025965
apa: Miranti, R., Septianto, R. D., Ibáñez, M., Kovalenko, M. V., Matsushita, N.,
Iwasa, Y., & Bisri, S. Z. (2020). Electron transport in iodide-capped core@shell
PbTe@PbS colloidal nanocrystal solids. Applied Physics Letters. AIP Publishing.
https://doi.org/10.1063/5.0025965
chicago: Miranti, Retno, Ricky Dwi Septianto, Maria Ibáñez, Maksym V. Kovalenko,
Nobuhiro Matsushita, Yoshihiro Iwasa, and Satria Zulkarnaen Bisri. “Electron Transport
in Iodide-Capped Core@shell PbTe@PbS Colloidal Nanocrystal Solids.” Applied
Physics Letters. AIP Publishing, 2020. https://doi.org/10.1063/5.0025965.
ieee: R. Miranti et al., “Electron transport in iodide-capped core@shell
PbTe@PbS colloidal nanocrystal solids,” Applied Physics Letters, vol. 117,
no. 17. AIP Publishing, 2020.
ista: Miranti R, Septianto RD, Ibáñez M, Kovalenko MV, Matsushita N, Iwasa Y, Bisri
SZ. 2020. Electron transport in iodide-capped core@shell PbTe@PbS colloidal nanocrystal
solids. Applied Physics Letters. 117(17), 173101.
mla: Miranti, Retno, et al. “Electron Transport in Iodide-Capped Core@shell PbTe@PbS
Colloidal Nanocrystal Solids.” Applied Physics Letters, vol. 117, no. 17,
173101, AIP Publishing, 2020, doi:10.1063/5.0025965.
short: R. Miranti, R.D. Septianto, M. Ibáñez, M.V. Kovalenko, N. Matsushita, Y.
Iwasa, S.Z. Bisri, Applied Physics Letters 117 (2020).
date_created: 2020-11-09T08:05:43Z
date_published: 2020-10-26T00:00:00Z
date_updated: 2023-09-05T11:57:23Z
day: '26'
department:
- _id: MaIb
doi: 10.1063/5.0025965
external_id:
isi:
- '000591639700001'
intvolume: ' 117'
isi: 1
issue: '17'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1063/5.0025965
month: '10'
oa: 1
oa_version: Published Version
publication: Applied Physics Letters
publication_identifier:
eissn:
- 1077-3118
issn:
- 0003-6951
publication_status: published
publisher: AIP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Electron transport in iodide-capped core@shell PbTe@PbS colloidal nanocrystal
solids
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 117
year: '2020'
...
---
_id: '8747'
abstract:
- lang: eng
text: "Appropriately designed nanocomposites allow improving the thermoelectric
performance by several mechanisms, including phonon scattering, modulation doping
and energy filtering, while additionally promoting better mechanical properties
than those of crystalline materials. Here, a strategy for producing Bi2Te3–Cu2xTe
nanocomposites based on the consolidation of heterostructured nanoparticles is
described and the thermoelectric properties of the obtained materials are investigated.
We first detail a two-step solution-based process to produce Bi2Te3–Cu2xTe heteronanostructures,
based on the growth of Cu2xTe nanocrystals on the surface of Bi2Te3 nanowires.
We characterize the structural and chemical properties of the synthesized nanostructures
and of the nanocomposites\r\nproduced by hot-pressing the particles at moderate
temperatures. Besides, the transport properties of the nanocomposites are investigated
as a function of the amount of Cu introduced. Overall, the presence of Cu decreases
the material thermal conductivity through promotion of phonon scattering, modulates
the charge carrier concentration through electron spillover, and increases the
Seebeck coefficient through filtering of charge carriers at energy barriers. These
effects result in an improvement of over 50% of the thermoelectric figure of merit
of Bi2Te3."
acknowledgement: "This work was supported by the European Regional Development Funds
and by the Spanish Ministerio de Economı´a y\r\nCompetitividad through the project
SEHTOP (ENE2016-77798-C4-3-R). Y. Z. and X. H., thank the China Scholarship Council
for scholarship support. M. C. has received funding from the European Union’s Horizon
2020 Research and Innovation programme under the Marie Skłodowska-Curie Grant Agreement
No. 665385. M. I. acknowledges financial support from IST Austria. Y. L. acknowledges
funding from the European Union’s Horizon 2020 Research and Innovation Programme
under the Marie Sklodowska-Curie grant agreement no. 754411. ICN2 acknowledges funding
from Generalitat de Catalunya 2017 SGR 327 and the Spanish MINECO project ENE2017-85087-C3.
ICN2 is supported by the Severo Ochoa program from the Spanish MINECO (grant no.
SEV-2017-0706) and is funded by the CERCA Programme/Generalitat de Catalunya. Part
of the present work has been performed in the framework of Universitat \r\nAuto`noma
de Barcelona Materials Science PhD program."
article_processing_charge: No
article_type: original
author:
- first_name: Yu
full_name: Zhang, Yu
last_name: Zhang
- first_name: Yu
full_name: Liu, Yu
id: 2A70014E-F248-11E8-B48F-1D18A9856A87
last_name: Liu
orcid: 0000-0001-7313-6740
- first_name: Mariano
full_name: Calcabrini, Mariano
last_name: Calcabrini
- first_name: Congcong
full_name: Xing, Congcong
last_name: Xing
- first_name: Xu
full_name: Han, Xu
last_name: Han
- first_name: Jordi
full_name: Arbiol, Jordi
last_name: Arbiol
- first_name: Doris
full_name: Cadavid, Doris
last_name: Cadavid
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
- first_name: Andreu
full_name: Cabot, Andreu
last_name: Cabot
citation:
ama: Zhang Y, Liu Y, Calcabrini M, et al. Bismuth telluride-copper telluride nanocomposites
from heterostructured building blocks. Journal of Materials Chemistry C.
2020;8(40):14092-14099. doi:10.1039/D0TC02182B
apa: Zhang, Y., Liu, Y., Calcabrini, M., Xing, C., Han, X., Arbiol, J., … Cabot,
A. (2020). Bismuth telluride-copper telluride nanocomposites from heterostructured
building blocks. Journal of Materials Chemistry C. Royal Society of Chemistry.
https://doi.org/10.1039/D0TC02182B
chicago: Zhang, Yu, Yu Liu, Mariano Calcabrini, Congcong Xing, Xu Han, Jordi Arbiol,
Doris Cadavid, Maria Ibáñez, and Andreu Cabot. “Bismuth Telluride-Copper Telluride
Nanocomposites from Heterostructured Building Blocks.” Journal of Materials
Chemistry C. Royal Society of Chemistry, 2020. https://doi.org/10.1039/D0TC02182B.
ieee: Y. Zhang et al., “Bismuth telluride-copper telluride nanocomposites
from heterostructured building blocks,” Journal of Materials Chemistry C,
vol. 8, no. 40. Royal Society of Chemistry, pp. 14092–14099, 2020.
ista: Zhang Y, Liu Y, Calcabrini M, Xing C, Han X, Arbiol J, Cadavid D, Ibáñez M,
Cabot A. 2020. Bismuth telluride-copper telluride nanocomposites from heterostructured
building blocks. Journal of Materials Chemistry C. 8(40), 14092–14099.
mla: Zhang, Yu, et al. “Bismuth Telluride-Copper Telluride Nanocomposites from Heterostructured
Building Blocks.” Journal of Materials Chemistry C, vol. 8, no. 40, Royal
Society of Chemistry, 2020, pp. 14092–99, doi:10.1039/D0TC02182B.
short: Y. Zhang, Y. Liu, M. Calcabrini, C. Xing, X. Han, J. Arbiol, D. Cadavid,
M. Ibáñez, A. Cabot, Journal of Materials Chemistry C 8 (2020) 14092–14099.
corr_author: '1'
date_created: 2020-11-09T08:37:51Z
date_published: 2020-10-28T00:00:00Z
date_updated: 2025-04-14T07:43:50Z
day: '28'
department:
- _id: MaIb
doi: 10.1039/D0TC02182B
ec_funded: 1
external_id:
isi:
- '000581559100015'
intvolume: ' 8'
isi: 1
issue: '40'
language:
- iso: eng
month: '10'
oa_version: None
page: 14092-14099
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Journal of Materials Chemistry C
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: Bismuth telluride-copper telluride nanocomposites from heterostructured building
blocks
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 8
year: '2020'
...
---
_id: '8750'
abstract:
- lang: eng
text: "Efficiently handling time-triggered and possibly nondeterministic switches\r\nfor
hybrid systems reachability is a challenging task. In this paper we present\r\nan
approach based on conservative set-based enclosure of the dynamics that can\r\nhandle
systems with uncertain parameters and inputs, where the uncertainties\r\nare bound
to given intervals. The method is evaluated on the plant model of an\r\nexperimental
electro-mechanical braking system with periodic controller. In\r\nthis model,
the fast-switching controller dynamics requires simulation time\r\nscales of the
order of nanoseconds. Accurate set-based computations for\r\nrelatively large
time horizons are known to be expensive. However, by\r\nappropriately decoupling
the time variable with respect to the spatial\r\nvariables, and enclosing the
uncertain parameters using interval matrix maps\r\nacting on zonotopes, we show
that the computation time can be lowered to 5000\r\ntimes faster with respect
to previous works. This is a step forward in formal\r\nverification of hybrid
systems because reduced run-times allow engineers to\r\nintroduce more expressiveness
in their models with a relatively inexpensive\r\ncomputational cost."
article_number: '9314994'
article_processing_charge: No
arxiv: 1
author:
- first_name: Marcelo
full_name: Forets, Marcelo
last_name: Forets
- first_name: Daniel
full_name: Freire, Daniel
last_name: Freire
- first_name: Christian
full_name: Schilling, Christian
id: 3A2F4DCE-F248-11E8-B48F-1D18A9856A87
last_name: Schilling
orcid: 0000-0003-3658-1065
citation:
ama: 'Forets M, Freire D, Schilling C. Efficient reachability analysis of parametric
linear hybrid systems with time-triggered transitions. In: 18th ACM-IEEE International
Conference on Formal Methods and Models for System Design. IEEE; 2020. doi:10.1109/MEMOCODE51338.2020.9314994'
apa: 'Forets, M., Freire, D., & Schilling, C. (2020). Efficient reachability
analysis of parametric linear hybrid systems with time-triggered transitions.
In 18th ACM-IEEE International Conference on Formal Methods and Models for
System Design. Virtual Conference: IEEE. https://doi.org/10.1109/MEMOCODE51338.2020.9314994'
chicago: Forets, Marcelo, Daniel Freire, and Christian Schilling. “Efficient Reachability
Analysis of Parametric Linear Hybrid Systems with Time-Triggered Transitions.”
In 18th ACM-IEEE International Conference on Formal Methods and Models for
System Design. IEEE, 2020. https://doi.org/10.1109/MEMOCODE51338.2020.9314994.
ieee: M. Forets, D. Freire, and C. Schilling, “Efficient reachability analysis of
parametric linear hybrid systems with time-triggered transitions,” in 18th
ACM-IEEE International Conference on Formal Methods and Models for System Design,
Virtual Conference, 2020.
ista: 'Forets M, Freire D, Schilling C. 2020. Efficient reachability analysis of
parametric linear hybrid systems with time-triggered transitions. 18th ACM-IEEE
International Conference on Formal Methods and Models for System Design. MEMOCODE:
Conference on Formal Methods and Models for System Design, 9314994.'
mla: Forets, Marcelo, et al. “Efficient Reachability Analysis of Parametric Linear
Hybrid Systems with Time-Triggered Transitions.” 18th ACM-IEEE International
Conference on Formal Methods and Models for System Design, 9314994, IEEE,
2020, doi:10.1109/MEMOCODE51338.2020.9314994.
short: M. Forets, D. Freire, C. Schilling, in:, 18th ACM-IEEE International Conference
on Formal Methods and Models for System Design, IEEE, 2020.
conference:
end_date: 2020-12-04
location: Virtual Conference
name: 'MEMOCODE: Conference on Formal Methods and Models for System Design'
start_date: 2020-12-02
date_created: 2020-11-10T07:04:57Z
date_published: 2020-12-04T00:00:00Z
date_updated: 2025-04-15T06:26:12Z
day: '04'
department:
- _id: ToHe
doi: 10.1109/MEMOCODE51338.2020.9314994
ec_funded: 1
external_id:
arxiv:
- '2006.12325'
isi:
- '000661920400013'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2006.12325
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: Formal methods for the design and analysis of complex systems
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: 18th ACM-IEEE International Conference on Formal Methods and Models for
System Design
publication_identifier:
isbn:
- '9781728191485'
publication_status: published
publisher: IEEE
quality_controlled: '1'
scopus_import: '1'
status: public
title: Efficient reachability analysis of parametric linear hybrid systems with time-triggered
transitions
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
year: '2020'
...
---
_id: '8758'
abstract:
- lang: eng
text: We consider various modeling levels for spatially homogeneous chemical reaction
systems, namely the chemical master equation, the chemical Langevin dynamics,
and the reaction-rate equation. Throughout we restrict our study to the case where
the microscopic system satisfies the detailed-balance condition. The latter allows
us to enrich the systems with a gradient structure, i.e. the evolution is given
by a gradient-flow equation. We present the arising links between the associated
gradient structures that are driven by the relative entropy of the detailed-balance
steady state. The limit of large volumes is studied in the sense of evolutionary
Γ-convergence of gradient flows. Moreover, we use the gradient structures to derive
hybrid models for coupling different modeling levels.
acknowledgement: The research of A.M. was partially supported by the Deutsche Forschungsgemeinschaft
(DFG) via the Collaborative Research Center SFB 1114 Scaling Cascades in Complex
Systems (Project No. 235221301), through the Subproject C05 Effective models for
materials and interfaces with multiple scales. J.M. gratefully acknowledges support
by the European Research Council (ERC) under the European Union’s Horizon 2020 research
and innovation programme (Grant Agreement No. 716117), and by the Austrian Science
Fund (FWF), Project SFB F65. The authors thank Christof Schütte, Robert I. A. Patterson,
and Stefanie Winkelmann for helpful and stimulating discussions. Open access funding
provided by Austrian Science Fund (FWF).
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Jan
full_name: Maas, Jan
id: 4C5696CE-F248-11E8-B48F-1D18A9856A87
last_name: Maas
orcid: 0000-0002-0845-1338
- first_name: Alexander
full_name: Mielke, Alexander
last_name: Mielke
citation:
ama: Maas J, Mielke A. Modeling of chemical reaction systems with detailed balance
using gradient structures. Journal of Statistical Physics. 2020;181(6):2257-2303.
doi:10.1007/s10955-020-02663-4
apa: Maas, J., & Mielke, A. (2020). Modeling of chemical reaction systems with
detailed balance using gradient structures. Journal of Statistical Physics.
Springer Nature. https://doi.org/10.1007/s10955-020-02663-4
chicago: Maas, Jan, and Alexander Mielke. “Modeling of Chemical Reaction Systems
with Detailed Balance Using Gradient Structures.” Journal of Statistical Physics.
Springer Nature, 2020. https://doi.org/10.1007/s10955-020-02663-4.
ieee: J. Maas and A. Mielke, “Modeling of chemical reaction systems with detailed
balance using gradient structures,” Journal of Statistical Physics, vol.
181, no. 6. Springer Nature, pp. 2257–2303, 2020.
ista: Maas J, Mielke A. 2020. Modeling of chemical reaction systems with detailed
balance using gradient structures. Journal of Statistical Physics. 181(6), 2257–2303.
mla: Maas, Jan, and Alexander Mielke. “Modeling of Chemical Reaction Systems with
Detailed Balance Using Gradient Structures.” Journal of Statistical Physics,
vol. 181, no. 6, Springer Nature, 2020, pp. 2257–303, doi:10.1007/s10955-020-02663-4.
short: J. Maas, A. Mielke, Journal of Statistical Physics 181 (2020) 2257–2303.
corr_author: '1'
date_created: 2020-11-15T23:01:18Z
date_published: 2020-12-01T00:00:00Z
date_updated: 2025-06-12T07:01:39Z
day: '01'
ddc:
- '510'
department:
- _id: JaMa
doi: 10.1007/s10955-020-02663-4
ec_funded: 1
external_id:
arxiv:
- '2004.02831'
isi:
- '000587107200002'
pmid:
- '33268907'
file:
- access_level: open_access
checksum: bc2b63a90197b97cbc73eccada4639f5
content_type: application/pdf
creator: dernst
date_created: 2021-02-04T10:29:11Z
date_updated: 2021-02-04T10:29:11Z
file_id: '9087'
file_name: 2020_JourStatPhysics_Maas.pdf
file_size: 753596
relation: main_file
success: 1
file_date_updated: 2021-02-04T10:29:11Z
has_accepted_license: '1'
intvolume: ' 181'
isi: 1
issue: '6'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 2257-2303
pmid: 1
project:
- _id: 256E75B8-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '716117'
name: Optimal Transport and Stochastic Dynamics
- _id: 260482E2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: F06504
name: Taming Complexity in Partial Differential Systems
publication: Journal of Statistical Physics
publication_identifier:
eissn:
- 1572-9613
issn:
- 0022-4715
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modeling of chemical reaction systems with detailed balance using gradient
structures
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 181
year: '2020'
...
---
_id: '8761'
acknowledged_ssus:
- _id: ScienComp
article_processing_charge: No
author:
- first_name: Ruslan
full_name: Guseinov, Ruslan
id: 3AB45EE2-F248-11E8-B48F-1D18A9856A87
last_name: Guseinov
orcid: 0000-0001-9819-5077
citation:
ama: Guseinov R. Supplementary data for “Computational design of cold bent glass
façades.” 2020. doi:10.15479/AT:ISTA:8761
apa: Guseinov, R. (2020). Supplementary data for “Computational design of cold bent
glass façades.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8761
chicago: Guseinov, Ruslan. “Supplementary Data for ‘Computational Design of Cold
Bent Glass Façades.’” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8761.
ieee: R. Guseinov, “Supplementary data for ‘Computational design of cold bent glass
façades.’” Institute of Science and Technology Austria, 2020.
ista: Guseinov R. 2020. Supplementary data for ‘Computational design of cold bent
glass façades’, Institute of Science and Technology Austria, 10.15479/AT:ISTA:8761.
mla: Guseinov, Ruslan. Supplementary Data for “Computational Design of Cold Bent
Glass Façades.” Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8761.
short: R. Guseinov, (2020).
contributor:
- contributor_type: researcher
first_name: Konstantinos
last_name: Gavriil
- contributor_type: researcher
first_name: Ruslan
id: 3AB45EE2-F248-11E8-B48F-1D18A9856A87
last_name: Guseinov
orcid: 0000-0001-9819-5077
- contributor_type: researcher
first_name: Jesus
id: 2DC83906-F248-11E8-B48F-1D18A9856A87
last_name: Perez Rodriguez
- contributor_type: researcher
first_name: Davide
last_name: Pellis
- contributor_type: researcher
first_name: Paul M
id: 13C09E74-18D9-11E9-8878-32CFE5697425
last_name: Henderson
orcid: 0000-0002-5198-7445
- contributor_type: researcher
first_name: Florian
last_name: Rist
- contributor_type: researcher
first_name: Helmut
last_name: Pottmann
- contributor_type: researcher
first_name: Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
corr_author: '1'
date_created: 2020-11-16T10:47:18Z
date_published: 2020-11-23T00:00:00Z
date_updated: 2025-04-15T07:16:12Z
day: '23'
ddc:
- '000'
department:
- _id: BeBi
doi: 10.15479/AT:ISTA:8761
ec_funded: 1
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content_type: application/x-gzip
creator: rguseino
date_created: 2020-11-16T10:31:29Z
date_updated: 2020-11-16T10:31:29Z
file_id: '8762'
file_name: mdn_model.tar.gz
file_size: 15378270
relation: main_file
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content_type: application/x-gzip
creator: rguseino
date_created: 2020-11-16T10:43:23Z
date_updated: 2020-11-16T10:43:23Z
file_id: '8763'
file_name: optimal_panels_data.tar.gz
file_size: 615387734
relation: main_file
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content_type: text/plain
creator: rguseino
date_created: 2020-11-18T10:04:59Z
date_updated: 2020-11-18T10:04:59Z
file_id: '8770'
file_name: readme.txt
file_size: 1228
relation: main_file
success: 1
file_date_updated: 2020-11-18T10:04:59Z
has_accepted_license: '1'
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715767'
name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
Modeling'
publisher: Institute of Science and Technology Austria
related_material:
link:
- relation: software
url: https://github.com/russelmann/cold-glass-acm
record:
- id: '8562'
relation: used_in_publication
status: public
status: public
title: Supplementary data for "Computational design of cold bent glass façades"
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '8765'
abstract:
- lang: eng
text: This paper introduces a simple method for simulating highly anisotropic elastoplastic
material behaviors like the dissolution of fibrous phenomena (splintering wood,
shredding bales of hay) and materials composed of large numbers of irregularly‐shaped
bodies (piles of twigs, pencils, or cards). We introduce a simple transformation
of the anisotropic problem into an equivalent isotropic one, and we solve this
new “fictitious” isotropic problem using an existing simulator based on the material
point method. Our approach results in minimal changes to existing simulators,
and it allows us to re‐use popular isotropic plasticity models like the Drucker‐Prager
yield criterion instead of inventing new anisotropic plasticity models for every
phenomenon we wish to simulate.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: "We wish to thank the anonymous reviewers and the members of the
Visual Computing Group at IST Austria for their valuable feedback. This research
was supported by the Scientific Service Units (SSU) of IST Austria through resources
provided by Scientific Computing. We would also like to thank Joseph Teran and Chenfanfu
Jiang for the helpful discussions.\r\nThis project has received funding from the
European Research Council (ERC) under the European Union's Horizon 2020 research
and innovation programme under grant agreement No. 638176."
article_processing_charge: No
article_type: original
author:
- first_name: Camille
full_name: Schreck, Camille
id: 2B14B676-F248-11E8-B48F-1D18A9856A87
last_name: Schreck
- first_name: Christopher J
full_name: Wojtan, Christopher J
id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
last_name: Wojtan
orcid: 0000-0001-6646-5546
citation:
ama: Schreck C, Wojtan C. A practical method for animating anisotropic elastoplastic
materials. Computer Graphics Forum. 2020;39(2):89-99. doi:10.1111/cgf.13914
apa: Schreck, C., & Wojtan, C. (2020). A practical method for animating anisotropic
elastoplastic materials. Computer Graphics Forum. Wiley. https://doi.org/10.1111/cgf.13914
chicago: Schreck, Camille, and Chris Wojtan. “A Practical Method for Animating Anisotropic
Elastoplastic Materials.” Computer Graphics Forum. Wiley, 2020. https://doi.org/10.1111/cgf.13914.
ieee: C. Schreck and C. Wojtan, “A practical method for animating anisotropic elastoplastic
materials,” Computer Graphics Forum, vol. 39, no. 2. Wiley, pp. 89–99,
2020.
ista: Schreck C, Wojtan C. 2020. A practical method for animating anisotropic elastoplastic
materials. Computer Graphics Forum. 39(2), 89–99.
mla: Schreck, Camille, and Chris Wojtan. “A Practical Method for Animating Anisotropic
Elastoplastic Materials.” Computer Graphics Forum, vol. 39, no. 2, Wiley,
2020, pp. 89–99, doi:10.1111/cgf.13914.
short: C. Schreck, C. Wojtan, Computer Graphics Forum 39 (2020) 89–99.
date_created: 2020-11-17T09:35:10Z
date_published: 2020-05-01T00:00:00Z
date_updated: 2024-10-22T09:58:14Z
day: '01'
ddc:
- '000'
department:
- _id: ChWo
doi: 10.1111/cgf.13914
ec_funded: 1
external_id:
isi:
- '000548709600008'
file:
- access_level: open_access
checksum: 7605f605acd84d0942b48bc7a1c2d72e
content_type: application/pdf
creator: dernst
date_created: 2020-11-23T09:05:13Z
date_updated: 2020-11-23T09:05:13Z
file_id: '8796'
file_name: 2020_poff_revisited.pdf
file_size: 38969122
relation: main_file
success: 1
file_date_updated: 2020-11-23T09:05:13Z
has_accepted_license: '1'
intvolume: ' 39'
isi: 1
issue: '2'
keyword:
- Computer Networks and Communications
language:
- iso: eng
month: '05'
oa: 1
oa_version: Submitted Version
page: 89-99
project:
- _id: 2533E772-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '638176'
name: 'Big Splash: Efficient Simulation of Natural Phenomena at Extremely Large
Scales'
publication: Computer Graphics Forum
publication_identifier:
eissn:
- 1467-8659
issn:
- 0167-7055
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: A practical method for animating anisotropic elastoplastic materials
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 39
year: '2020'
...
---
_id: '8766'
abstract:
- lang: eng
text: "The “procedural” approach to animating ocean waves is the dominant algorithm
for animating larger bodies of water in\r\ninteractive applications as well as
in off-line productions — it provides high visual quality with a low computational
demand. In this paper, we widen the applicability of procedural water wave animation
with an extension that guarantees the satisfaction of boundary conditions imposed
by terrain while still approximating physical wave behavior. In combination with
a particle system that models wave breaking, foam, and spray, this allows us to
naturally model waves interacting with beaches and rocks. Our system is able to
animate waves at large scales at interactive frame rates on a commodity PC."
article_processing_charge: No
article_type: original
author:
- first_name: Stefan
full_name: Jeschke, Stefan
id: 44D6411A-F248-11E8-B48F-1D18A9856A87
last_name: Jeschke
- first_name: Christian
full_name: Hafner, Christian
id: 400429CC-F248-11E8-B48F-1D18A9856A87
last_name: Hafner
- first_name: Nuttapong
full_name: Chentanez, Nuttapong
last_name: Chentanez
- first_name: Miles
full_name: Macklin, Miles
last_name: Macklin
- first_name: Matthias
full_name: Müller-Fischer, Matthias
last_name: Müller-Fischer
- first_name: Christopher J
full_name: Wojtan, Christopher J
id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
last_name: Wojtan
orcid: 0000-0001-6646-5546
citation:
ama: Jeschke S, Hafner C, Chentanez N, Macklin M, Müller-Fischer M, Wojtan C. Making
procedural water waves boundary-aware. Computer Graphics forum. 2020;39(8):47-54.
doi:10.1111/cgf.14100
apa: 'Jeschke, S., Hafner, C., Chentanez, N., Macklin, M., Müller-Fischer, M., &
Wojtan, C. (2020). Making procedural water waves boundary-aware. Computer Graphics
Forum. Online Symposium: Wiley. https://doi.org/10.1111/cgf.14100'
chicago: Jeschke, Stefan, Christian Hafner, Nuttapong Chentanez, Miles Macklin,
Matthias Müller-Fischer, and Chris Wojtan. “Making Procedural Water Waves Boundary-Aware.”
Computer Graphics Forum. Wiley, 2020. https://doi.org/10.1111/cgf.14100.
ieee: S. Jeschke, C. Hafner, N. Chentanez, M. Macklin, M. Müller-Fischer, and C.
Wojtan, “Making procedural water waves boundary-aware,” Computer Graphics forum,
vol. 39, no. 8. Wiley, pp. 47–54, 2020.
ista: Jeschke S, Hafner C, Chentanez N, Macklin M, Müller-Fischer M, Wojtan C. 2020.
Making procedural water waves boundary-aware. Computer Graphics forum. 39(8),
47–54.
mla: Jeschke, Stefan, et al. “Making Procedural Water Waves Boundary-Aware.” Computer
Graphics Forum, vol. 39, no. 8, Wiley, 2020, pp. 47–54, doi:10.1111/cgf.14100.
short: S. Jeschke, C. Hafner, N. Chentanez, M. Macklin, M. Müller-Fischer, C. Wojtan,
Computer Graphics Forum 39 (2020) 47–54.
conference:
end_date: 2020-10-09
location: Online Symposium
name: 'SCA: Symposium on Computer Animation'
start_date: 2020-10-06
date_created: 2020-11-17T10:47:48Z
date_published: 2020-12-01T00:00:00Z
date_updated: 2024-10-22T09:58:15Z
day: '01'
department:
- _id: ChWo
- _id: BeBi
doi: 10.1111/cgf.14100
ec_funded: 1
external_id:
isi:
- '000591780400005'
intvolume: ' 39'
isi: 1
issue: '8'
language:
- iso: eng
month: '12'
oa_version: None
page: 47-54
project:
- _id: 2533E772-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '638176'
name: 'Big Splash: Efficient Simulation of Natural Phenomena at Extremely Large
Scales'
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715767'
name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
Modeling'
publication: Computer Graphics forum
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Making procedural water waves boundary-aware
type: journal_article
user_id: 2EBD1598-F248-11E8-B48F-1D18A9856A87
volume: 39
year: '2020'
...
---
_id: '8767'
abstract:
- lang: eng
text: Resources are rarely distributed uniformly within a population. Heterogeneity
in the concentration of a drug, the quality of breeding sites, or wealth can all
affect evolutionary dynamics. In this study, we represent a collection of properties
affecting the fitness at a given location using a color. A green node is rich
in resources while a red node is poorer. More colors can represent a broader spectrum
of resource qualities. For a population evolving according to the birth-death
Moran model, the first question we address is which structures, identified by
graph connectivity and graph coloring, are evolutionarily equivalent. We prove
that all properly two-colored, undirected, regular graphs are evolutionarily equivalent
(where “properly colored” means that no two neighbors have the same color). We
then compare the effects of background heterogeneity on properly two-colored graphs
to those with alternative schemes in which the colors are permuted. Finally, we
discuss dynamic coloring as a model for spatiotemporal resource fluctuations,
and we illustrate that random dynamic colorings often diminish the effects of
background heterogeneity relative to a proper two-coloring.
acknowledgement: 'We thank Igor Erovenko for many helpful comments on an earlier version
of this paper. : Army Research Laboratory (grant W911NF-18-2-0265) (M.A.N.); the
Bill & Melinda Gates Foundation (grant OPP1148627) (M.A.N.); the NVIDIA Corporation
(A.M.). The funders had no role in study design, data collection and analysis, decision
to publish, or preparation of the manuscript.'
article_number: e1008402
article_processing_charge: No
article_type: original
author:
- first_name: Kamran
full_name: Kaveh, Kamran
last_name: Kaveh
- first_name: Alex
full_name: McAvoy, Alex
last_name: McAvoy
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin A.
full_name: Nowak, Martin A.
last_name: Nowak
citation:
ama: Kaveh K, McAvoy A, Chatterjee K, Nowak MA. The Moran process on 2-chromatic
graphs. PLOS Computational Biology. 2020;16(11). doi:10.1371/journal.pcbi.1008402
apa: Kaveh, K., McAvoy, A., Chatterjee, K., & Nowak, M. A. (2020). The Moran
process on 2-chromatic graphs. PLOS Computational Biology. Public Library
of Science. https://doi.org/10.1371/journal.pcbi.1008402
chicago: Kaveh, Kamran, Alex McAvoy, Krishnendu Chatterjee, and Martin A. Nowak.
“The Moran Process on 2-Chromatic Graphs.” PLOS Computational Biology.
Public Library of Science, 2020. https://doi.org/10.1371/journal.pcbi.1008402.
ieee: K. Kaveh, A. McAvoy, K. Chatterjee, and M. A. Nowak, “The Moran process on
2-chromatic graphs,” PLOS Computational Biology, vol. 16, no. 11. Public
Library of Science, 2020.
ista: Kaveh K, McAvoy A, Chatterjee K, Nowak MA. 2020. The Moran process on 2-chromatic
graphs. PLOS Computational Biology. 16(11), e1008402.
mla: Kaveh, Kamran, et al. “The Moran Process on 2-Chromatic Graphs.” PLOS Computational
Biology, vol. 16, no. 11, e1008402, Public Library of Science, 2020, doi:10.1371/journal.pcbi.1008402.
short: K. Kaveh, A. McAvoy, K. Chatterjee, M.A. Nowak, PLOS Computational Biology
16 (2020).
date_created: 2020-11-18T07:20:23Z
date_published: 2020-11-05T00:00:00Z
date_updated: 2025-06-12T07:02:01Z
day: '05'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1371/journal.pcbi.1008402
external_id:
isi:
- '000591317200004'
pmid:
- '33151935'
file:
- access_level: open_access
checksum: 555456dd0e47bcf9e0994bcb95577e88
content_type: application/pdf
creator: dernst
date_created: 2020-11-18T07:26:10Z
date_updated: 2020-11-18T07:26:10Z
file_id: '8768'
file_name: 2020_PlosCompBio_Kaveh.pdf
file_size: 2498594
relation: main_file
success: 1
file_date_updated: 2020-11-18T07:26:10Z
has_accepted_license: '1'
intvolume: ' 16'
isi: 1
issue: '11'
keyword:
- Ecology
- Modelling and Simulation
- Computational Theory and Mathematics
- Genetics
- Ecology
- Evolution
- Behavior and Systematics
- Molecular Biology
- Cellular and Molecular Neuroscience
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: PLOS Computational Biology
publication_identifier:
eissn:
- 1553-7358
issn:
- 1553-734X
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: The Moran process on 2-chromatic graphs
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2020'
...
---
_id: '8769'
abstract:
- lang: eng
text: One of the hallmarks of quantum statistics, tightly entwined with the concept
of topological phases of matter, is the prediction of anyons. Although anyons
are predicted to be realized in certain fractional quantum Hall systems, they
have not yet been unambiguously detected in experiment. Here we introduce a simple
quantum impurity model, where bosonic or fermionic impurities turn into anyons
as a consequence of their interaction with the surrounding many-particle bath.
A cloud of phonons dresses each impurity in such a way that it effectively attaches
fluxes or vortices to it and thereby converts it into an Abelian anyon. The corresponding
quantum impurity model, first, provides a different approach to the numerical
solution of the many-anyon problem, along with a concrete perspective of anyons
as emergent quasiparticles built from composite bosons or fermions. More importantly,
the model paves the way toward realizing anyons using impurities in crystal lattices
as well as ultracold gases. In particular, we consider two heavy electrons interacting
with a two-dimensional lattice crystal in a magnetic field, and show that when
the impurity-bath system is rotated at the cyclotron frequency, impurities behave
as anyons as a consequence of the angular momentum exchange between the impurities
and the bath. A possible experimental realization is proposed by identifying the
statistics parameter in terms of the mean-square distance of the impurities and
the magnetization of the impurity-bath system, both of which are accessible to
experiment. Another proposed application is impurities immersed in a two-dimensional
weakly interacting Bose gas.
acknowledgement: "We are grateful to M. Correggi, A. Deuchert, and P. Schmelcher for
valuable discussions. We also thank the anonymous referees for helping to clarify
a few important points in the experimental realization. A.G. acknowledges support
by the European Unions Horizon 2020 research and innovation program under the Marie
Skłodowska-Curie grant agreement\r\nNo 754411. D.L. acknowledges financial support
from the Goran Gustafsson Foundation (grant no. 1804) and LMU Munich. R.S., M.L.,
and N.R. gratefully acknowledge financial support by the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme
(grant agreements No 694227, No 801770, and No 758620, respectively)."
article_number: '144109'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Enderalp
full_name: Yakaboylu, Enderalp
id: 38CB71F6-F248-11E8-B48F-1D18A9856A87
last_name: Yakaboylu
orcid: 0000-0001-5973-0874
- first_name: Areg
full_name: Ghazaryan, Areg
id: 4AF46FD6-F248-11E8-B48F-1D18A9856A87
last_name: Ghazaryan
orcid: 0000-0001-9666-3543
- first_name: D.
full_name: Lundholm, D.
last_name: Lundholm
- first_name: N.
full_name: Rougerie, N.
last_name: Rougerie
- first_name: Mikhail
full_name: Lemeshko, Mikhail
id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
last_name: Lemeshko
orcid: 0000-0002-6990-7802
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Yakaboylu E, Ghazaryan A, Lundholm D, Rougerie N, Lemeshko M, Seiringer R.
Quantum impurity model for anyons. Physical Review B. 2020;102(14). doi:10.1103/physrevb.102.144109
apa: Yakaboylu, E., Ghazaryan, A., Lundholm, D., Rougerie, N., Lemeshko, M., &
Seiringer, R. (2020). Quantum impurity model for anyons. Physical Review B.
American Physical Society. https://doi.org/10.1103/physrevb.102.144109
chicago: Yakaboylu, Enderalp, Areg Ghazaryan, D. Lundholm, N. Rougerie, Mikhail
Lemeshko, and Robert Seiringer. “Quantum Impurity Model for Anyons.” Physical
Review B. American Physical Society, 2020. https://doi.org/10.1103/physrevb.102.144109.
ieee: E. Yakaboylu, A. Ghazaryan, D. Lundholm, N. Rougerie, M. Lemeshko, and R.
Seiringer, “Quantum impurity model for anyons,” Physical Review B, vol.
102, no. 14. American Physical Society, 2020.
ista: Yakaboylu E, Ghazaryan A, Lundholm D, Rougerie N, Lemeshko M, Seiringer R.
2020. Quantum impurity model for anyons. Physical Review B. 102(14), 144109.
mla: Yakaboylu, Enderalp, et al. “Quantum Impurity Model for Anyons.” Physical
Review B, vol. 102, no. 14, 144109, American Physical Society, 2020, doi:10.1103/physrevb.102.144109.
short: E. Yakaboylu, A. Ghazaryan, D. Lundholm, N. Rougerie, M. Lemeshko, R. Seiringer,
Physical Review B 102 (2020).
date_created: 2020-11-18T07:34:17Z
date_published: 2020-10-01T00:00:00Z
date_updated: 2025-04-14T07:26:54Z
day: '01'
department:
- _id: MiLe
- _id: RoSe
doi: 10.1103/physrevb.102.144109
ec_funded: 1
external_id:
arxiv:
- '1912.07890'
isi:
- '000582563300001'
intvolume: ' 102'
isi: 1
issue: '14'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1912.07890
month: '10'
oa: 1
oa_version: Preprint
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694227'
name: Analysis of quantum many-body systems
- _id: 2688CF98-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '801770'
name: 'Angulon: physics and applications of a new quasiparticle'
publication: Physical Review B
publication_identifier:
eissn:
- 2469-9969
issn:
- 2469-9950
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Quantum impurity model for anyons
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 102
year: '2020'
...
---
_id: '8809'
abstract:
- lang: eng
text: When divergent populations are connected by gene flow, the establishment of
complete reproductive isolation usually requires the joint action of multiple
barrier effects. One example where multiple barrier effects are coupled consists
of a single trait that is under divergent natural selection and also mediates
assortative mating. Such multiple-effect traits can strongly reduce gene flow.
However, there are few cases where patterns of assortative mating have been described
quantitatively and their impact on gene flow has been determined. Two ecotypes
of the coastal marine snail, Littorina saxatilis, occur in North Atlantic rocky-shore
habitats dominated by either crab predation or wave action. There is evidence
for divergent natural selection acting on size, and size-assortative mating has
previously been documented. Here, we analyze the mating pattern in L. saxatilis
with respect to size in intensively-sampled transects across boundaries between
the habitats. We show that the mating pattern is mostly conserved between ecotypes
and that it generates both assortment and directional sexual selection for small
male size. Using simulations, we show that the mating pattern can contribute to
reproductive isolation between ecotypes but the barrier to gene flow is likely
strengthened more by sexual selection than by assortment.
article_processing_charge: No
author:
- first_name: Samuel
full_name: Perini, Samuel
last_name: Perini
- first_name: Marina
full_name: Rafajlovic, Marina
last_name: Rafajlovic
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
- first_name: Roger
full_name: Butlin, Roger
last_name: Butlin
citation:
ama: 'Perini S, Rafajlovic M, Westram AM, Johannesson K, Butlin R. Data from: Assortative
mating, sexual selection and their consequences for gene flow in Littorina. 2020.
doi:10.5061/dryad.qrfj6q5cn'
apa: 'Perini, S., Rafajlovic, M., Westram, A. M., Johannesson, K., & Butlin,
R. (2020). Data from: Assortative mating, sexual selection and their consequences
for gene flow in Littorina. Dryad. https://doi.org/10.5061/dryad.qrfj6q5cn'
chicago: 'Perini, Samuel, Marina Rafajlovic, Anja M Westram, Kerstin Johannesson,
and Roger Butlin. “Data from: Assortative Mating, Sexual Selection and Their Consequences
for Gene Flow in Littorina.” Dryad, 2020. https://doi.org/10.5061/dryad.qrfj6q5cn.'
ieee: 'S. Perini, M. Rafajlovic, A. M. Westram, K. Johannesson, and R. Butlin, “Data
from: Assortative mating, sexual selection and their consequences for gene flow
in Littorina.” Dryad, 2020.'
ista: 'Perini S, Rafajlovic M, Westram AM, Johannesson K, Butlin R. 2020. Data from:
Assortative mating, sexual selection and their consequences for gene flow in Littorina,
Dryad, 10.5061/dryad.qrfj6q5cn.'
mla: 'Perini, Samuel, et al. Data from: Assortative Mating, Sexual Selection
and Their Consequences for Gene Flow in Littorina. Dryad, 2020, doi:10.5061/dryad.qrfj6q5cn.'
short: S. Perini, M. Rafajlovic, A.M. Westram, K. Johannesson, R. Butlin, (2020).
date_created: 2020-11-25T11:07:25Z
date_published: 2020-07-01T00:00:00Z
date_updated: 2025-07-10T11:54:59Z
day: '01'
department:
- _id: NiBa
doi: 10.5061/dryad.qrfj6q5cn
has_accepted_license: '1'
license: https://creativecommons.org/publicdomain/zero/1.0/
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.qrfj6q5cn
month: '07'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '7995'
relation: used_in_publication
status: public
status: public
title: 'Data from: Assortative mating, sexual selection and their consequences for
gene flow in Littorina'
tmp:
image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
name: Creative Commons Public Domain Dedication (CC0 1.0)
short: CC0 (1.0)
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2020'
...
---
_id: '8813'
abstract:
- lang: eng
text: 'In mammals, chromatin marks at imprinted genes are asymmetrically inherited
to control parentally-biased gene expression. This control is thought predominantly
to involve parent-specific differentially methylated regions (DMR) in genomic
DNA. However, neither parent-of-origin-specific transcription nor DMRs have been
comprehensively mapped. We here address this by integrating transcriptomic and
epigenomic approaches in mouse preimplantation embryos (blastocysts). Transcriptome-analysis
identified 71 genes expressed with previously unknown parent-of-origin-specific
expression in blastocysts (nBiX: novel blastocyst-imprinted expression). Uniparental
expression of nBiX genes disappeared soon after implantation. Micro-whole-genome
bisulfite sequencing (μWGBS) of individual uniparental blastocysts detected 859
DMRs. Only 18% of nBiXs were associated with a DMR, whereas 60% were associated
with parentally-biased H3K27me3. This suggests a major role for Polycomb-mediated
imprinting in blastocysts. Five nBiX-clusters contained at least one known imprinted
gene, and five novel clusters contained exclusively nBiX-genes. These data suggest
a complex program of stage-specific imprinting involving different tiers of regulation.'
article_processing_charge: No
author:
- first_name: Laura
full_name: Santini, Laura
last_name: Santini
- first_name: Florian
full_name: Halbritter, Florian
last_name: Halbritter
- first_name: Fabian
full_name: Titz-Teixeira, Fabian
last_name: Titz-Teixeira
- first_name: Toru
full_name: Suzuki, Toru
last_name: Suzuki
- first_name: Maki
full_name: Asami, Maki
last_name: Asami
- first_name: Julia
full_name: Ramesmayer, Julia
last_name: Ramesmayer
- first_name: Xiaoyan
full_name: Ma, Xiaoyan
last_name: Ma
- first_name: Andreas
full_name: Lackner, Andreas
last_name: Lackner
- first_name: Nick
full_name: Warr, Nick
last_name: Warr
- first_name: Florian
full_name: Pauler, Florian
id: 48EA0138-F248-11E8-B48F-1D18A9856A87
last_name: Pauler
orcid: 0000-0002-7462-0048
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
- first_name: Ernest
full_name: Laue, Ernest
last_name: Laue
- first_name: Matthias
full_name: Farlik, Matthias
last_name: Farlik
- first_name: Christoph
full_name: Bock, Christoph
last_name: Bock
- first_name: Andreas
full_name: Beyer, Andreas
last_name: Beyer
- first_name: Anthony C. F.
full_name: Perry, Anthony C. F.
last_name: Perry
- first_name: Martin
full_name: Leeb, Martin
last_name: Leeb
citation:
ama: Santini L, Halbritter F, Titz-Teixeira F, et al. Novel imprints in mouse blastocysts
are predominantly DNA methylation independent. bioRxiv. doi:10.1101/2020.11.03.366948
apa: Santini, L., Halbritter, F., Titz-Teixeira, F., Suzuki, T., Asami, M., Ramesmayer,
J., … Leeb, M. (n.d.). Novel imprints in mouse blastocysts are predominantly DNA
methylation independent. bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2020.11.03.366948
chicago: Santini, Laura, Florian Halbritter, Fabian Titz-Teixeira, Toru Suzuki,
Maki Asami, Julia Ramesmayer, Xiaoyan Ma, et al. “Novel Imprints in Mouse Blastocysts
Are Predominantly DNA Methylation Independent.” BioRxiv. Cold Spring Harbor
Laboratory, n.d. https://doi.org/10.1101/2020.11.03.366948.
ieee: L. Santini et al., “Novel imprints in mouse blastocysts are predominantly
DNA methylation independent,” bioRxiv. Cold Spring Harbor Laboratory.
ista: Santini L, Halbritter F, Titz-Teixeira F, Suzuki T, Asami M, Ramesmayer J,
Ma X, Lackner A, Warr N, Pauler F, Hippenmeyer S, Laue E, Farlik M, Bock C, Beyer
A, Perry ACF, Leeb M. Novel imprints in mouse blastocysts are predominantly DNA
methylation independent. bioRxiv, 10.1101/2020.11.03.366948.
mla: Santini, Laura, et al. “Novel Imprints in Mouse Blastocysts Are Predominantly
DNA Methylation Independent.” BioRxiv, Cold Spring Harbor Laboratory, doi:10.1101/2020.11.03.366948.
short: L. Santini, F. Halbritter, F. Titz-Teixeira, T. Suzuki, M. Asami, J. Ramesmayer,
X. Ma, A. Lackner, N. Warr, F. Pauler, S. Hippenmeyer, E. Laue, M. Farlik, C.
Bock, A. Beyer, A.C.F. Perry, M. Leeb, BioRxiv (n.d.).
date_created: 2020-11-26T07:17:19Z
date_published: 2020-11-05T00:00:00Z
date_updated: 2023-09-12T11:05:28Z
day: '05'
department:
- _id: SiHi
doi: 10.1101/2020.11.03.366948
external_id:
pmid:
- 'PPR234457 '
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2020.11.03.366948
month: '11'
oa: 1
oa_version: Preprint
pmid: 1
publication: bioRxiv
publication_status: submitted
publisher: Cold Spring Harbor Laboratory
status: public
title: Novel imprints in mouse blastocysts are predominantly DNA methylation independent
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '8834'
abstract:
- lang: eng
text: "This data collection contains the transport data for figures presented in
the supplementary material of \"Enhancement of Proximity Induced Superconductivity
in Planar Germanium\" by K. Aggarwal, et. al. \r\nThe measurements were done using
Labber Software and the data is stored in the hdf5 file format. The files can
be opened using either the Labber Log Browser (https://labber.org/overview/) or
Labber Python API (http://labber.org/online-doc/api/LogFile.html).\r\n"
article_processing_charge: No
author:
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
citation:
ama: Katsaros G. Enhancement of proximity induced superconductivity in planar Germanium.
2020. doi:10.15479/AT:ISTA:8834
apa: Katsaros, G. (2020). Enhancement of proximity induced superconductivity in
planar Germanium. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8834
chicago: Katsaros, Georgios. “Enhancement of Proximity Induced Superconductivity
in Planar Germanium.” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8834.
ieee: G. Katsaros, “Enhancement of proximity induced superconductivity in planar
Germanium.” Institute of Science and Technology Austria, 2020.
ista: Katsaros G. 2020. Enhancement of proximity induced superconductivity in planar
Germanium, Institute of Science and Technology Austria, 10.15479/AT:ISTA:8834.
mla: Katsaros, Georgios. Enhancement of Proximity Induced Superconductivity in
Planar Germanium. Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8834.
short: G. Katsaros, (2020).
contributor:
- contributor_type: project_member
first_name: Kushagra
id: b22ab905-3539-11eb-84c3-fc159dcd79cb
last_name: Aggarwal
- contributor_type: project_member
first_name: Andrea C
id: 340F461A-F248-11E8-B48F-1D18A9856A87
last_name: Hofmann
- contributor_type: project_member
first_name: Daniel
id: 4C473F58-F248-11E8-B48F-1D18A9856A87
last_name: Jirovec
- contributor_type: project_member
first_name: Ivan
id: 2A307FE2-F248-11E8-B48F-1D18A9856A87
last_name: Prieto Gonzalez
- contributor_type: project_member
first_name: Amir
last_name: Sammak
- contributor_type: project_member
first_name: Marc
last_name: Botifoll
- contributor_type: project_member
first_name: Sara
last_name: Marti-Sanchez
- contributor_type: project_member
first_name: Menno
last_name: Veldhorst
- contributor_type: project_member
first_name: Jordi
last_name: Arbiol
- contributor_type: project_member
first_name: Giordano
last_name: Scappucci
- contributor_type: project_leader
first_name: Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
corr_author: '1'
date_created: 2020-12-02T10:49:30Z
date_published: 2020-12-02T00:00:00Z
date_updated: 2025-04-15T08:38:16Z
day: '02'
ddc:
- '530'
department:
- _id: GeKa
doi: 10.15479/AT:ISTA:8834
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year: '2020'
...
---
_id: '8914'
abstract:
- lang: eng
text: Amyotrophic lateral sclerosis (ALS) leads to a loss of specific motor neuron
populations in the spinal cord and cortex. Emerging evidence suggests that interneurons
may also be affected, but a detailed characterization of interneuron loss and
its potential impacts on motor neuron loss and disease progression is lacking.
To examine this issue, the fate of V1 inhibitory neurons during ALS was assessed
in the ventral spinal cord using the SODG93A mouse model. The V1 population makes
up ∼30% of all ventral inhibitory neurons, ∼50% of direct inhibitory synaptic
contacts onto motor neuron cell bodies, and is thought to play a key role in modulating
motor output, in part through recurrent and reciprocal inhibitory circuits. We
find that approximately half of V1 inhibitory neurons are lost in SODG93A mice
at late disease stages, but that this loss is delayed relative to the loss of
motor neurons and V2a excitatory neurons. We further identify V1 subpopulations
based on transcription factor expression that are differentially susceptible to
degeneration in SODG93A mice. At an early disease stage, we show that V1 synaptic
contacts with motor neuron cell bodies increase, suggesting an upregulation of
inhibition before V1 neurons are lost in substantial numbers. These data support
a model in which progressive changes in V1 synaptic contacts early in disease,
and in select V1 subpopulations at later stages, represent a compensatory upregulation
and then deleterious breakdown of specific interneuron circuits within the spinal
cord.
acknowledgement: This work was made possible by the generous support of Project ALS.
Imaging and related analyses were facilitated by The Waitt Advanced Biophotonics
Center Core at the Salk Institute, supported by grants from NIH-NCI CCSG (P30 014195)
and NINDS Neuroscience Center (NS072031). The authors would like to additionally
thank Drs. Jane Dodd, Robert Brownstone, and Laskaro Zagoraiou for helpful comments
on the manuscript. This manuscript is dedicated to Tom Jessell, an inspirational
scientist, friend and mentor.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Alina
full_name: Salamatina, Alina
last_name: Salamatina
- first_name: Jerry H
full_name: Yang, Jerry H
last_name: Yang
- first_name: Susan
full_name: Brenner-Morton, Susan
last_name: Brenner-Morton
- first_name: 'Jay B '
full_name: 'Bikoff, Jay B '
last_name: Bikoff
- first_name: Linjing
full_name: Fang, Linjing
last_name: Fang
- first_name: Christopher R
full_name: Kintner, Christopher R
last_name: Kintner
- first_name: Thomas M
full_name: Jessell, Thomas M
last_name: Jessell
- first_name: Lora Beatrice Jaeger
full_name: Sweeney, Lora Beatrice Jaeger
id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
last_name: Sweeney
orcid: 0000-0001-9242-5601
citation:
ama: Salamatina A, Yang JH, Brenner-Morton S, et al. Differential loss of spinal
interneurons in a mouse model of ALS. Neuroscience. 2020;450:81-95. doi:10.1016/j.neuroscience.2020.08.011
apa: Salamatina, A., Yang, J. H., Brenner-Morton, S., Bikoff, J. B., Fang, L., Kintner,
C. R., … Sweeney, L. B. (2020). Differential loss of spinal interneurons in a
mouse model of ALS. Neuroscience. Elsevier. https://doi.org/10.1016/j.neuroscience.2020.08.011
chicago: Salamatina, Alina, Jerry H Yang, Susan Brenner-Morton, Jay B Bikoff, Linjing
Fang, Christopher R Kintner, Thomas M Jessell, and Lora B. Sweeney. “Differential
Loss of Spinal Interneurons in a Mouse Model of ALS.” Neuroscience. Elsevier,
2020. https://doi.org/10.1016/j.neuroscience.2020.08.011.
ieee: A. Salamatina et al., “Differential loss of spinal interneurons in
a mouse model of ALS,” Neuroscience, vol. 450. Elsevier, pp. 81–95, 2020.
ista: Salamatina A, Yang JH, Brenner-Morton S, Bikoff JB, Fang L, Kintner CR, Jessell
TM, Sweeney LB. 2020. Differential loss of spinal interneurons in a mouse model
of ALS. Neuroscience. 450, 81–95.
mla: Salamatina, Alina, et al. “Differential Loss of Spinal Interneurons in a Mouse
Model of ALS.” Neuroscience, vol. 450, Elsevier, 2020, pp. 81–95, doi:10.1016/j.neuroscience.2020.08.011.
short: A. Salamatina, J.H. Yang, S. Brenner-Morton, J.B. Bikoff, L. Fang, C.R. Kintner,
T.M. Jessell, L.B. Sweeney, Neuroscience 450 (2020) 81–95.
corr_author: '1'
date_created: 2020-12-03T11:47:31Z
date_published: 2020-12-01T00:00:00Z
date_updated: 2024-10-09T21:00:14Z
day: '01'
ddc:
- '570'
department:
- _id: LoSw
doi: 10.1016/j.neuroscience.2020.08.011
external_id:
isi:
- '000595588700008'
pmid:
- '32858144'
file:
- access_level: open_access
checksum: da7413c819e079720669c82451b49294
content_type: application/pdf
creator: dernst
date_created: 2020-12-03T11:45:26Z
date_updated: 2020-12-03T11:45:26Z
file_id: '8915'
file_name: 2020_Neuroscience_Salamatina.pdf
file_size: 4071247
relation: main_file
success: 1
file_date_updated: 2020-12-03T11:45:26Z
has_accepted_license: '1'
intvolume: ' 450'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '12'
oa: 1
oa_version: Published Version
page: 81-95
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential loss of spinal interneurons in a mouse model of ALS
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 450
year: '2020'
...
---
_id: '8924'
abstract:
- lang: eng
text: 'Maintaining fertility in a fluctuating environment is key to the reproductive
success of flowering plants. Meiosis and pollen formation are particularly sensitive
to changes in growing conditions, especially temperature. We have previously identified
cyclin-dependent kinase G1 (CDKG1) as a master regulator of temperature-dependent
meiosis and this may involve the regulation of alternative splicing (AS), including
of its own transcript. CDKG1 mRNA can undergo several AS events, potentially producing
two protein variants: CDKG1L and CDKG1S, differing in their N-terminal domain
which may be involved in co-factor interaction. In leaves, both isoforms have
distinct temperature-dependent functions on target mRNA processing, but their
role in pollen development is unknown. In the present study, we characterize the
role of CDKG1L and CDKG1S in maintaining Arabidopsis fertility. We show that the
long (L) form is necessary and sufficient to rescue the fertility defects of the
cdkg1-1 mutant, while the short (S) form is unable to rescue fertility. On the
other hand, an extra copy of CDKG1L reduces fertility. In addition, mutation of
the ATP binding pocket of the kinase indicates that kinase activity is necessary
for the function of CDKG1. Kinase mutants of CDKG1L and CDKG1S correctly localize
to the cell nucleus and nucleus and cytoplasm, respectively, but are unable to
rescue either the fertility or the splicing defects of the cdkg1-1 mutant. Furthermore,
we show that there is partial functional overlap between CDKG1 and its paralog
CDKG2 that could in part be explained by overlapping gene expression.'
acknowledgement: CN, DD, NF-F, and JD were funded by the BBSRC (grant number BB/M009459/1).
NK and AM were funded through the ERASMUS+Program. NC was funded by the VIPS Program
of the Austrian Federal Ministry of Science and Research and the City of Vienna.
article_number: '586870'
article_processing_charge: No
article_type: original
author:
- first_name: Candida
full_name: Nibau, Candida
last_name: Nibau
- first_name: Despoina
full_name: Dadarou, Despoina
last_name: Dadarou
- first_name: Nestoras
full_name: Kargios, Nestoras
last_name: Kargios
- first_name: Areti
full_name: Mallioura, Areti
last_name: Mallioura
- first_name: Narcis
full_name: Fernandez-Fuentes, Narcis
last_name: Fernandez-Fuentes
- first_name: Nicola
full_name: Cavallari, Nicola
id: 457160E6-F248-11E8-B48F-1D18A9856A87
last_name: Cavallari
- first_name: John H.
full_name: Doonan, John H.
last_name: Doonan
citation:
ama: Nibau C, Dadarou D, Kargios N, et al. A functional kinase is necessary for
cyclin-dependent kinase G1 (CDKG1) to maintain fertility at high ambient temperature
in Arabidopsis. Frontiers in Plant Science. 2020;11. doi:10.3389/fpls.2020.586870
apa: Nibau, C., Dadarou, D., Kargios, N., Mallioura, A., Fernandez-Fuentes, N.,
Cavallari, N., & Doonan, J. H. (2020). A functional kinase is necessary for
cyclin-dependent kinase G1 (CDKG1) to maintain fertility at high ambient temperature
in Arabidopsis. Frontiers in Plant Science. Frontiers. https://doi.org/10.3389/fpls.2020.586870
chicago: Nibau, Candida, Despoina Dadarou, Nestoras Kargios, Areti Mallioura, Narcis
Fernandez-Fuentes, Nicola Cavallari, and John H. Doonan. “A Functional Kinase
Is Necessary for Cyclin-Dependent Kinase G1 (CDKG1) to Maintain Fertility at High
Ambient Temperature in Arabidopsis.” Frontiers in Plant Science. Frontiers,
2020. https://doi.org/10.3389/fpls.2020.586870.
ieee: C. Nibau et al., “A functional kinase is necessary for cyclin-dependent
kinase G1 (CDKG1) to maintain fertility at high ambient temperature in Arabidopsis,”
Frontiers in Plant Science, vol. 11. Frontiers, 2020.
ista: Nibau C, Dadarou D, Kargios N, Mallioura A, Fernandez-Fuentes N, Cavallari
N, Doonan JH. 2020. A functional kinase is necessary for cyclin-dependent kinase
G1 (CDKG1) to maintain fertility at high ambient temperature in Arabidopsis. Frontiers
in Plant Science. 11, 586870.
mla: Nibau, Candida, et al. “A Functional Kinase Is Necessary for Cyclin-Dependent
Kinase G1 (CDKG1) to Maintain Fertility at High Ambient Temperature in Arabidopsis.”
Frontiers in Plant Science, vol. 11, 586870, Frontiers, 2020, doi:10.3389/fpls.2020.586870.
short: C. Nibau, D. Dadarou, N. Kargios, A. Mallioura, N. Fernandez-Fuentes, N.
Cavallari, J.H. Doonan, Frontiers in Plant Science 11 (2020).
date_created: 2020-12-06T23:01:14Z
date_published: 2020-11-10T00:00:00Z
date_updated: 2025-06-12T07:02:22Z
day: '10'
ddc:
- '580'
department:
- _id: EvBe
doi: 10.3389/fpls.2020.586870
external_id:
isi:
- '000591637000001'
pmid:
- '33240303'
file:
- access_level: open_access
checksum: 1c0ee6ce9950aa665d6a5cc64aa6b752
content_type: application/pdf
creator: dernst
date_created: 2020-12-09T09:14:19Z
date_updated: 2020-12-09T09:14:19Z
file_id: '8929'
file_name: 2020_Frontiers_Nibau.pdf
file_size: 1833244
relation: main_file
success: 1
file_date_updated: 2020-12-09T09:14:19Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Frontiers in Plant Science
publication_identifier:
eissn:
- 1664-462X
publication_status: published
publisher: Frontiers
quality_controlled: '1'
scopus_import: '1'
status: public
title: A functional kinase is necessary for cyclin-dependent kinase G1 (CDKG1) to
maintain fertility at high ambient temperature in Arabidopsis
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2020'
...
---
_id: '8930'
abstract:
- lang: eng
text: Phenomenological relations such as Ohm’s or Fourier’s law have a venerable
history in physics but are still scarce in biology. This situation restrains predictive
theory. Here, we build on bacterial “growth laws,” which capture physiological
feedback between translation and cell growth, to construct a minimal biophysical
model for the combined action of ribosome-targeting antibiotics. Our model predicts
drug interactions like antagonism or synergy solely from responses to individual
drugs. We provide analytical results for limiting cases, which agree well with
numerical results. We systematically refine the model by including direct physical
interactions of different antibiotics on the ribosome. In a limiting case, our
model provides a mechanistic underpinning for recent predictions of higher-order
interactions that were derived using entropy maximization. We further refine the
model to include the effects of antibiotics that mimic starvation and the presence
of resistance genes. We describe the impact of a starvation-mimicking antibiotic
on drug interactions analytically and verify it experimentally. Our extended model
suggests a change in the type of drug interaction that depends on the strength
of resistance, which challenges established rescaling paradigms. We experimentally
show that the presence of unregulated resistance genes can lead to altered drug
interaction, which agrees with the prediction of the model. While minimal, the
model is readily adaptable and opens the door to predicting interactions of second
and higher-order in a broad range of biological systems.
article_processing_charge: No
author:
- first_name: Bor
full_name: Kavcic, Bor
id: 350F91D2-F248-11E8-B48F-1D18A9856A87
last_name: Kavcic
orcid: 0000-0001-6041-254X
citation:
ama: Kavcic B. Analysis scripts and research data for the paper “Minimal biophysical
model of combined antibiotic action.” 2020. doi:10.15479/AT:ISTA:8930
apa: Kavcic, B. (2020). Analysis scripts and research data for the paper “Minimal
biophysical model of combined antibiotic action.” Institute of Science and Technology
Austria. https://doi.org/10.15479/AT:ISTA:8930
chicago: Kavcic, Bor. “Analysis Scripts and Research Data for the Paper ‘Minimal
Biophysical Model of Combined Antibiotic Action.’” Institute of Science and Technology
Austria, 2020. https://doi.org/10.15479/AT:ISTA:8930.
ieee: B. Kavcic, “Analysis scripts and research data for the paper ‘Minimal biophysical
model of combined antibiotic action.’” Institute of Science and Technology Austria,
2020.
ista: Kavcic B. 2020. Analysis scripts and research data for the paper ‘Minimal
biophysical model of combined antibiotic action’, Institute of Science and Technology
Austria, 10.15479/AT:ISTA:8930.
mla: Kavcic, Bor. Analysis Scripts and Research Data for the Paper “Minimal Biophysical
Model of Combined Antibiotic Action.” Institute of Science and Technology
Austria, 2020, doi:10.15479/AT:ISTA:8930.
short: B. Kavcic, (2020).
contributor:
- contributor_type: supervisor
first_name: Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
- contributor_type: supervisor
first_name: Tobias
id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
last_name: Bollenbach
corr_author: '1'
date_created: 2020-12-09T15:04:02Z
date_published: 2020-12-10T00:00:00Z
date_updated: 2025-06-12T06:33:18Z
day: '10'
ddc:
- '570'
department:
- _id: GaTk
doi: 10.15479/AT:ISTA:8930
file:
- access_level: open_access
checksum: 60a818edeffaa7da1ebf5f8fbea9ba18
content_type: application/zip
creator: bkavcic
date_created: 2020-12-09T15:00:19Z
date_updated: 2020-12-09T15:00:19Z
file_id: '8932'
file_name: PLoSCompBiol2020_datarep.zip
file_size: 315494370
relation: main_file
success: 1
file_date_updated: 2020-12-09T15:00:19Z
has_accepted_license: '1'
keyword:
- Escherichia coli
- antibiotic combinations
- translation
- growth laws
- drug interactions
- bacterial physiology
- translation inhibitors
month: '12'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '8997'
relation: used_in_publication
status: public
status: public
title: Analysis scripts and research data for the paper "Minimal biophysical model
of combined antibiotic action"
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '8944'
abstract:
- lang: eng
text: "Superconductor insulator transition in transverse magnetic field is studied
in the highly disordered MoC film with the product of the Fermi momentum and the
mean free path kF*l close to unity. Surprisingly, the Zeeman paramagnetic effects
dominate over orbital coupling on both sides of the transition. In superconducting
state it is evidenced by a high upper critical magnetic field \U0001D435\U0001D4502,
by its square root dependence on temperature, as well as by the Zeeman splitting
of the quasiparticle density of states (DOS) measured by scanning tunneling microscopy.
At \U0001D435\U0001D4502 a logarithmic anomaly in DOS is observed. This anomaly
is further enhanced in increasing magnetic field, which is explained by the Zeeman
splitting of the Altshuler-Aronov DOS driving\r\nthe system into a more insulating
or resistive state. Spin dependent Altshuler-Aronov correction is also needed
to explain the transport behavior above \U0001D435\U0001D4502."
acknowledgement: 'We gratefully acknowledge helpful conversations with B.L. Altshuler
and R. Hlubina. The work was supported by the projects APVV-18-0358, VEGA 2/0058/20,
VEGA 1/0743/19 the European Microkelvin Platform, the COST action CA16218 (Nanocohybri)
and by U.S. Steel Košice. '
article_number: '180508'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Martin
full_name: Zemlicka, Martin
id: 2DCF8DE6-F248-11E8-B48F-1D18A9856A87
last_name: Zemlicka
- first_name: M.
full_name: Kopčík, M.
last_name: Kopčík
- first_name: P.
full_name: Szabó, P.
last_name: Szabó
- first_name: T.
full_name: Samuely, T.
last_name: Samuely
- first_name: J.
full_name: Kačmarčík, J.
last_name: Kačmarčík
- first_name: P.
full_name: Neilinger, P.
last_name: Neilinger
- first_name: M.
full_name: Grajcar, M.
last_name: Grajcar
- first_name: P.
full_name: Samuely, P.
last_name: Samuely
citation:
ama: 'Zemlicka M, Kopčík M, Szabó P, et al. Zeeman-driven superconductor-insulator
transition in strongly disordered MoC films: Scanning tunneling microscopy and
transport studies in a transverse magnetic field. Physical Review B. 2020;102(18).
doi:10.1103/PhysRevB.102.180508'
apa: 'Zemlicka, M., Kopčík, M., Szabó, P., Samuely, T., Kačmarčík, J., Neilinger,
P., … Samuely, P. (2020). Zeeman-driven superconductor-insulator transition in
strongly disordered MoC films: Scanning tunneling microscopy and transport studies
in a transverse magnetic field. Physical Review B. American Physical Society.
https://doi.org/10.1103/PhysRevB.102.180508'
chicago: 'Zemlicka, Martin, M. Kopčík, P. Szabó, T. Samuely, J. Kačmarčík, P. Neilinger,
M. Grajcar, and P. Samuely. “Zeeman-Driven Superconductor-Insulator Transition
in Strongly Disordered MoC Films: Scanning Tunneling Microscopy and Transport
Studies in a Transverse Magnetic Field.” Physical Review B. American Physical
Society, 2020. https://doi.org/10.1103/PhysRevB.102.180508.'
ieee: 'M. Zemlicka et al., “Zeeman-driven superconductor-insulator transition
in strongly disordered MoC films: Scanning tunneling microscopy and transport
studies in a transverse magnetic field,” Physical Review B, vol. 102, no.
18. American Physical Society, 2020.'
ista: 'Zemlicka M, Kopčík M, Szabó P, Samuely T, Kačmarčík J, Neilinger P, Grajcar
M, Samuely P. 2020. Zeeman-driven superconductor-insulator transition in strongly
disordered MoC films: Scanning tunneling microscopy and transport studies in a
transverse magnetic field. Physical Review B. 102(18), 180508.'
mla: 'Zemlicka, Martin, et al. “Zeeman-Driven Superconductor-Insulator Transition
in Strongly Disordered MoC Films: Scanning Tunneling Microscopy and Transport
Studies in a Transverse Magnetic Field.” Physical Review B, vol. 102, no.
18, 180508, American Physical Society, 2020, doi:10.1103/PhysRevB.102.180508.'
short: M. Zemlicka, M. Kopčík, P. Szabó, T. Samuely, J. Kačmarčík, P. Neilinger,
M. Grajcar, P. Samuely, Physical Review B 102 (2020).
date_created: 2020-12-13T23:01:21Z
date_published: 2020-11-01T00:00:00Z
date_updated: 2025-07-10T12:01:27Z
day: '01'
department:
- _id: JoFi
doi: 10.1103/PhysRevB.102.180508
external_id:
arxiv:
- '2011.04329'
isi:
- '000591509900003'
intvolume: ' 102'
isi: 1
issue: '18'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2011.04329
month: '11'
oa: 1
oa_version: Preprint
publication: Physical Review B
publication_identifier:
eissn:
- 2469-9969
issn:
- 2469-9950
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Zeeman-driven superconductor-insulator transition in strongly disordered MoC
films: Scanning tunneling microscopy and transport studies in a transverse magnetic
field'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 102
year: '2020'
...
---
_id: '8949'
abstract:
- lang: eng
text: Development of the nervous system undergoes important transitions,
including one from neurogenesis to gliogenesis which occurs late during embryonic
gestation. Here we report on clonal analysis of gliogenesis in mice using Mosaic
Analysis with Double Markers (MADM) with quantitative and computational methods.
Results reveal that developmental gliogenesis in the cerebral cortex occurs in
a fraction of earlier neurogenic clones, accelerating around E16.5, and giving
rise to both astrocytes and oligodendrocytes. Moreover, MADM-based genetic deletion
of the epidermal growth factor receptor (Egfr) in gliogenic clones revealed that
Egfr is cell autonomously required for gliogenesis in the mouse dorsolateral cortices.
A broad range in the proliferation capacity, symmetry of clones, and competitive
advantage of MADM cells was evident in clones that contained one cellular lineage
with double dosage of Egfr relative to their environment, while their sibling
Egfr-null cells failed to generate glia. Remarkably, the total numbers of glia
in MADM clones balance out regardless of significant alterations in clonal symmetries.
The variability in glial clones shows stochastic patterns that we define mathematically,
which are different from the deterministic patterns in neuronal clones. This study
sets a foundation for studying the biological significance of stochastic and deterministic
clonal principles underlying tissue development, and identifying mechanisms that
differentiate between neurogenesis and gliogenesis.
acknowledgement: This research was funded by grants from the National Institutes of
Health to H.T.G. (R01NS098370 and R01NS089795). C.V.M. was supported by a National
Science Foundation Graduate Research Fellowship (DGE-1746939). R.B. was supported
by the FWF Lise-Meitner program (M 2416), and S.H. was supported by the European
Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
programme (grant agreement No 725780 LinPro).The authors thank members of the Ghashghaei
lab for discussions, technical support, and help with preparation of the manuscript.
article_number: '2662'
article_processing_charge: No
article_type: original
author:
- first_name: Xuying
full_name: Zhang, Xuying
last_name: Zhang
- first_name: Christine V.
full_name: Mennicke, Christine V.
last_name: Mennicke
- first_name: Guanxi
full_name: Xiao, Guanxi
last_name: Xiao
- first_name: Robert J
full_name: Beattie, Robert J
id: 2E26DF60-F248-11E8-B48F-1D18A9856A87
last_name: Beattie
orcid: 0000-0002-8483-8753
- first_name: Mansoor
full_name: Haider, Mansoor
last_name: Haider
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
- first_name: H. Troy
full_name: Ghashghaei, H. Troy
last_name: Ghashghaei
citation:
ama: Zhang X, Mennicke CV, Xiao G, et al. Clonal analysis of gliogenesis in the
cerebral cortex reveals stochastic expansion of glia and cell autonomous responses
to Egfr dosage. Cells. 2020;9(12). doi:10.3390/cells9122662
apa: Zhang, X., Mennicke, C. V., Xiao, G., Beattie, R. J., Haider, M., Hippenmeyer,
S., & Ghashghaei, H. T. (2020). Clonal analysis of gliogenesis in the cerebral
cortex reveals stochastic expansion of glia and cell autonomous responses to Egfr
dosage. Cells. MDPI. https://doi.org/10.3390/cells9122662
chicago: Zhang, Xuying, Christine V. Mennicke, Guanxi Xiao, Robert J Beattie, Mansoor
Haider, Simon Hippenmeyer, and H. Troy Ghashghaei. “Clonal Analysis of Gliogenesis
in the Cerebral Cortex Reveals Stochastic Expansion of Glia and Cell Autonomous
Responses to Egfr Dosage.” Cells. MDPI, 2020. https://doi.org/10.3390/cells9122662.
ieee: X. Zhang et al., “Clonal analysis of gliogenesis in the cerebral cortex
reveals stochastic expansion of glia and cell autonomous responses to Egfr dosage,”
Cells, vol. 9, no. 12. MDPI, 2020.
ista: Zhang X, Mennicke CV, Xiao G, Beattie RJ, Haider M, Hippenmeyer S, Ghashghaei
HT. 2020. Clonal analysis of gliogenesis in the cerebral cortex reveals stochastic
expansion of glia and cell autonomous responses to Egfr dosage. Cells. 9(12),
2662.
mla: Zhang, Xuying, et al. “Clonal Analysis of Gliogenesis in the Cerebral Cortex
Reveals Stochastic Expansion of Glia and Cell Autonomous Responses to Egfr Dosage.”
Cells, vol. 9, no. 12, 2662, MDPI, 2020, doi:10.3390/cells9122662.
short: X. Zhang, C.V. Mennicke, G. Xiao, R.J. Beattie, M. Haider, S. Hippenmeyer,
H.T. Ghashghaei, Cells 9 (2020).
date_created: 2020-12-14T08:04:03Z
date_published: 2020-12-11T00:00:00Z
date_updated: 2025-06-12T07:02:43Z
day: '11'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.3390/cells9122662
ec_funded: 1
external_id:
isi:
- '000601787300001'
pmid:
- '33322301'
file:
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checksum: 5095cbdc728c9a510c5761cf60a8861c
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creator: dernst
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file_id: '8950'
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success: 1
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intvolume: ' 9'
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issue: '12'
language:
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month: '12'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 264E56E2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02416
name: Molecular Mechanisms Regulating Gliogenesis in the Neocortex
- _id: 260018B0-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '725780'
name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: Cells
publication_identifier:
issn:
- 2073-4409
publication_status: published
publisher: MDPI
quality_controlled: '1'
scopus_import: '1'
status: public
title: Clonal analysis of gliogenesis in the cerebral cortex reveals stochastic expansion
of glia and cell autonomous responses to Egfr dosage
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2020'
...
---
_id: '8951'
abstract:
- lang: eng
text: Gene expression levels are influenced by multiple coexisting molecular mechanisms.
Some of these interactions, such as those of transcription factors and promoters
have been studied extensively. However, predicting phenotypes of gene regulatory
networks remains a major challenge. Here, we use a well-defined synthetic gene
regulatory network to study how network phenotypes depend on local genetic context,
i.e. the genetic neighborhood of a transcription factor and its relative position.
We show that one gene regulatory network with fixed topology can display not only
quantitatively but also qualitatively different phenotypes, depending solely on
the local genetic context of its components. Our results demonstrate that changes
in local genetic context can place a single transcriptional unit within two separate
regulons without the need for complex regulatory sequences. We propose that relative
order of individual transcriptional units, with its potential for combinatorial
complexity, plays an important role in shaping phenotypes of gene regulatory networks.
article_processing_charge: No
author:
- first_name: Anna A
full_name: Nagy-Staron, Anna A
id: 3ABC5BA6-F248-11E8-B48F-1D18A9856A87
last_name: Nagy-Staron
orcid: 0000-0002-1391-8377
citation:
ama: Nagy-Staron AA. Sequences of gene regulatory network permutations for the article
“Local genetic context shapes the function of a gene regulatory network.” 2020.
doi:10.15479/AT:ISTA:8951
apa: Nagy-Staron, A. A. (2020). Sequences of gene regulatory network permutations
for the article “Local genetic context shapes the function of a gene regulatory
network.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8951
chicago: Nagy-Staron, Anna A. “Sequences of Gene Regulatory Network Permutations
for the Article ‘Local Genetic Context Shapes the Function of a Gene Regulatory
Network.’” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8951.
ieee: A. A. Nagy-Staron, “Sequences of gene regulatory network permutations for
the article ‘Local genetic context shapes the function of a gene regulatory network.’”
Institute of Science and Technology Austria, 2020.
ista: Nagy-Staron AA. 2020. Sequences of gene regulatory network permutations for
the article ‘Local genetic context shapes the function of a gene regulatory network’,
Institute of Science and Technology Austria, 10.15479/AT:ISTA:8951.
mla: Nagy-Staron, Anna A. Sequences of Gene Regulatory Network Permutations for
the Article “Local Genetic Context Shapes the Function of a Gene Regulatory Network.”
Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8951.
short: A.A. Nagy-Staron, (2020).
contributor:
- contributor_type: project_member
first_name: Anna A
id: 3ABC5BA6-F248-11E8-B48F-1D18A9856A87
last_name: Nagy-Staron
- contributor_type: project_member
first_name: Kathrin
id: 3AEC8556-F248-11E8-B48F-1D18A9856A87
last_name: Tomasek
- contributor_type: project_member
first_name: Caroline
last_name: Caruso Carter
- contributor_type: project_member
first_name: Elisabeth
last_name: Sonnleitner
- contributor_type: project_member
first_name: Bor
id: 350F91D2-F248-11E8-B48F-1D18A9856A87
last_name: Kavcic
orcid: 0000-0001-6041-254X
- contributor_type: project_member
first_name: Tiago
last_name: Paixão
- contributor_type: project_manager
first_name: Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
corr_author: '1'
date_created: 2020-12-20T10:00:26Z
date_published: 2020-12-21T00:00:00Z
date_updated: 2025-06-12T06:36:16Z
day: '21'
ddc:
- '570'
department:
- _id: CaGu
doi: 10.15479/AT:ISTA:8951
file:
- access_level: open_access
checksum: f57862aeee1690c7effd2b1117d40ed1
content_type: text/plain
creator: bkavcic
date_created: 2020-12-20T09:52:52Z
date_updated: 2020-12-20T09:52:52Z
file_id: '8952'
file_name: readme.txt
file_size: 523
relation: main_file
success: 1
- access_level: open_access
checksum: f2c6d5232ec6d551b6993991e8689e9f
content_type: application/octet-stream
creator: bkavcic
date_created: 2020-12-20T22:01:44Z
date_updated: 2020-12-20T22:01:44Z
file_id: '8954'
file_name: GRNs Research depository.gb
file_size: 379228
relation: main_file
success: 1
file_date_updated: 2020-12-20T22:01:44Z
has_accepted_license: '1'
keyword:
- Gene regulatory networks
- Gene expression
- Escherichia coli
- Synthetic Biology
month: '12'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '9283'
relation: used_in_publication
status: public
status: public
title: Sequences of gene regulatory network permutations for the article "Local genetic
context shapes the function of a gene regulatory network"
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '8955'
abstract:
- lang: eng
text: Skeletal muscle activity is continuously modulated across physiologic states
to provide coordination, flexibility and responsiveness to body tasks and external
inputs. Despite the central role the muscular system plays in facilitating vital
body functions, the network of brain-muscle interactions required to control hundreds
of muscles and synchronize their activation in relation to distinct physiologic
states has not been investigated. Recent approaches have focused on general associations
between individual brain rhythms and muscle activation during movement tasks.
However, the specific forms of coupling, the functional network of cortico-muscular
coordination, and how network structure and dynamics are modulated by autonomic
regulation across physiologic states remains unknown. To identify and quantify
the cortico-muscular interaction network and uncover basic features of neuro-autonomic
control of muscle function, we investigate the coupling between synchronous bursts
in cortical rhythms and peripheral muscle activation during sleep and wake. Utilizing
the concept of time delay stability and a novel network physiology approach, we
find that the brain-muscle network exhibits complex dynamic patterns of communication
involving multiple brain rhythms across cortical locations and different electromyographic
frequency bands. Moreover, our results show that during each physiologic state
the cortico-muscular network is characterized by a specific profile of network
links strength, where particular brain rhythms play role of main mediators of
interaction and control. Further, we discover a hierarchical reorganization in
network structure across physiologic states, with high connectivity and network
link strength during wake, intermediate during REM and light sleep, and low during
deep sleep, a sleep-stage stratification that demonstrates a unique association
between physiologic states and cortico-muscular network structure. The reported
empirical observations are consistent across individual subjects, indicating universal
behavior in network structure and dynamics, and high sensitivity of cortico-muscular
control to changes in autonomic regulation, even at low levels of physical activity
and muscle tone during sleep. Our findings demonstrate previously unrecognized
basic principles of brain-muscle network communication and control, and provide
new perspectives on the regulatory mechanisms of brain dynamics and locomotor
activation, with potential clinical implications for neurodegenerative, movement
and sleep disorders, and for developing efficient treatment strategies.
acknowledgement: We acknowledge support from the W. M. Keck Foundation, National Institutes
of Health (NIH Grant 1R01-HL098437), the US-Israel Binational Science Foundation
(BSF Grant 2012219), and the Office of Naval Research (ONR Grant 000141010078).
FL acknowledges support also from the European Union's Horizon 2020 research and
innovation program under the Marie Sklodowska-Curie Grant Agreement No. 754411.
article_number: '558070'
article_processing_charge: No
article_type: original
author:
- first_name: Rossella
full_name: Rizzo, Rossella
last_name: Rizzo
- first_name: Xiyun
full_name: Zhang, Xiyun
last_name: Zhang
- first_name: Jilin W.J.L.
full_name: Wang, Jilin W.J.L.
last_name: Wang
- first_name: Fabrizio
full_name: Lombardi, Fabrizio
id: A057D288-3E88-11E9-986D-0CF4E5697425
last_name: Lombardi
orcid: 0000-0003-2623-5249
- first_name: Plamen Ch
full_name: Ivanov, Plamen Ch
last_name: Ivanov
citation:
ama: Rizzo R, Zhang X, Wang JWJL, Lombardi F, Ivanov PC. Network physiology of cortico–muscular
interactions. Frontiers in Physiology. 2020;11. doi:10.3389/fphys.2020.558070
apa: Rizzo, R., Zhang, X., Wang, J. W. J. L., Lombardi, F., & Ivanov, P. C.
(2020). Network physiology of cortico–muscular interactions. Frontiers in Physiology.
Frontiers. https://doi.org/10.3389/fphys.2020.558070
chicago: Rizzo, Rossella, Xiyun Zhang, Jilin W.J.L. Wang, Fabrizio Lombardi, and
Plamen Ch Ivanov. “Network Physiology of Cortico–Muscular Interactions.” Frontiers
in Physiology. Frontiers, 2020. https://doi.org/10.3389/fphys.2020.558070.
ieee: R. Rizzo, X. Zhang, J. W. J. L. Wang, F. Lombardi, and P. C. Ivanov, “Network
physiology of cortico–muscular interactions,” Frontiers in Physiology,
vol. 11. Frontiers, 2020.
ista: Rizzo R, Zhang X, Wang JWJL, Lombardi F, Ivanov PC. 2020. Network physiology
of cortico–muscular interactions. Frontiers in Physiology. 11, 558070.
mla: Rizzo, Rossella, et al. “Network Physiology of Cortico–Muscular Interactions.”
Frontiers in Physiology, vol. 11, 558070, Frontiers, 2020, doi:10.3389/fphys.2020.558070.
short: R. Rizzo, X. Zhang, J.W.J.L. Wang, F. Lombardi, P.C. Ivanov, Frontiers in
Physiology 11 (2020).
date_created: 2020-12-20T23:01:18Z
date_published: 2020-11-26T00:00:00Z
date_updated: 2025-04-14T07:43:50Z
day: '26'
ddc:
- '570'
department:
- _id: GaTk
doi: 10.3389/fphys.2020.558070
ec_funded: 1
external_id:
isi:
- '000596849400001'
pmid:
- '33324233'
file:
- access_level: open_access
checksum: ef9515b28c5619b7126c0f347958bcb3
content_type: application/pdf
creator: dernst
date_created: 2020-12-21T10:37:50Z
date_updated: 2020-12-21T10:37:50Z
file_id: '8961'
file_name: 2020_Frontiers_Rizzo.pdf
file_size: 13380030
relation: main_file
success: 1
file_date_updated: 2020-12-21T10:37:50Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Frontiers in Physiology
publication_identifier:
eissn:
- 1664042X
publication_status: published
publisher: Frontiers
quality_controlled: '1'
scopus_import: '1'
status: public
title: Network physiology of cortico–muscular interactions
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11
year: '2020'
...