---
_id: '14592'
abstract:
- lang: eng
  text: Cryo-electron microscopy (cryo-EM) of cellular specimens provides insights
    into biological processes and structures within a native context. However, a major
    challenge still lies in the efficient and reproducible preparation of adherent
    cells for subsequent cryo-EM analysis. This is due to the sensitivity of many
    cellular specimens to the varying seeding and culturing conditions required for
    EM experiments, the often limited amount of cellular material and also the fragility
    of EM grids and their substrate. Here, we present low-cost and reusable 3D printed
    grid holders, designed to improve specimen preparation when culturing challenging
    cellular samples directly on grids. The described grid holders increase cell culture
    reproducibility and throughput, and reduce the resources required for cell culturing.
    We show that grid holders can be integrated into various cryo-EM workflows, including
    micro-patterning approaches to control cell seeding on grids, and for generating
    samples for cryo-focused ion beam milling and cryo-electron tomography experiments.
    Their adaptable design allows for the generation of specialized grid holders customized
    to a large variety of applications.
article_processing_charge: No
author:
- first_name: Florian KM
  full_name: Schur, Florian KM
  id: 48AD8942-F248-11E8-B48F-1D18A9856A87
  last_name: Schur
  orcid: 0000-0003-4790-8078
citation:
  ama: Schur FK. STL-files for 3D-printed grid holders described in  Fäßler F, Zens
    B, et al.; 3D printed cell culture grid holders for improved cellular specimen
    preparation in cryo-electron microscopy. 2020. doi:<a href="https://doi.org/10.15479/AT:ISTA:14592">10.15479/AT:ISTA:14592</a>
  apa: Schur, F. K. (2020). STL-files for 3D-printed grid holders described in  Fäßler
    F, Zens B, et al.; 3D printed cell culture grid holders for improved cellular
    specimen preparation in cryo-electron microscopy. Institute of Science and Technology
    Austria. <a href="https://doi.org/10.15479/AT:ISTA:14592">https://doi.org/10.15479/AT:ISTA:14592</a>
  chicago: Schur, Florian KM. “STL-Files for 3D-Printed Grid Holders Described in 
    Fäßler F, Zens B, et Al.; 3D Printed Cell Culture Grid Holders for Improved Cellular
    Specimen Preparation in Cryo-Electron Microscopy.” Institute of Science and Technology
    Austria, 2020. <a href="https://doi.org/10.15479/AT:ISTA:14592">https://doi.org/10.15479/AT:ISTA:14592</a>.
  ieee: F. K. Schur, “STL-files for 3D-printed grid holders described in  Fäßler F,
    Zens B, et al.; 3D printed cell culture grid holders for improved cellular specimen
    preparation in cryo-electron microscopy.” Institute of Science and Technology
    Austria, 2020.
  ista: Schur FK. 2020. STL-files for 3D-printed grid holders described in  Fäßler
    F, Zens B, et al.; 3D printed cell culture grid holders for improved cellular
    specimen preparation in cryo-electron microscopy, Institute of Science and Technology
    Austria, <a href="https://doi.org/10.15479/AT:ISTA:14592">10.15479/AT:ISTA:14592</a>.
  mla: Schur, Florian KM. <i>STL-Files for 3D-Printed Grid Holders Described in  Fäßler
    F, Zens B, et Al.; 3D Printed Cell Culture Grid Holders for Improved Cellular
    Specimen Preparation in Cryo-Electron Microscopy</i>. Institute of Science and
    Technology Austria, 2020, doi:<a href="https://doi.org/10.15479/AT:ISTA:14592">10.15479/AT:ISTA:14592</a>.
  short: F.K. Schur, (2020).
contributor:
- contributor_type: researcher
  first_name: Florian
  id: 404F5528-F248-11E8-B48F-1D18A9856A87
  last_name: Fäßler
  orcid: 0000-0001-7149-769X
- contributor_type: researcher
  first_name: Bettina
  id: 45FD126C-F248-11E8-B48F-1D18A9856A87
  last_name: Zens
- contributor_type: researcher
  first_name: Robert
  id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
  last_name: Hauschild
- contributor_type: researcher
  first_name: Florian KM
  id: 48AD8942-F248-11E8-B48F-1D18A9856A87
  last_name: Schur
  orcid: 0000-0003-4790-8078
corr_author: '1'
date_created: 2023-11-22T15:00:57Z
date_published: 2020-12-01T00:00:00Z
date_updated: 2025-06-12T07:35:28Z
day: '01'
ddc:
- '570'
department:
- _id: FlSc
doi: 10.15479/AT:ISTA:14592
file:
- access_level: open_access
  checksum: 0108616e2a59e51879ea51299a29b091
  content_type: application/zip
  creator: fschur
  date_created: 2023-11-22T14:58:44Z
  date_updated: 2023-11-22T14:58:44Z
  file_id: '14593'
  file_name: 3Dprint-files_download_v2.zip
  file_size: 49297
  relation: main_file
  success: 1
- access_level: open_access
  checksum: 4c66ddedee4d01c1c4a7978208350cfc
  content_type: text/plain
  creator: cchlebak
  date_created: 2023-12-01T10:39:59Z
  date_updated: 2023-12-01T10:39:59Z
  file_id: '14637'
  file_name: readme.txt
  file_size: 641
  relation: main_file
  success: 1
file_date_updated: 2023-12-01T10:39:59Z
has_accepted_license: '1'
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 9B954C5C-BA93-11EA-9121-9846C619BF3A
  grant_number: P33367
  name: Structure and isoform diversity of the Arp2/3 complex
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '8586'
    relation: research_data
    status: public
status: public
title: STL-files for 3D-printed grid holders described in  Fäßler F, Zens B, et al.;
  3D printed cell culture grid holders for improved cellular specimen preparation
  in cryo-electron microscopy
tmp:
  image: /images/cc_by_nc_sa.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
    BY-NC-SA 4.0)
  short: CC BY-NC-SA (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '14694'
abstract:
- lang: eng
  text: We study the unique solution m of the Dyson equation \( -m(z)^{-1} = z\1 -
    a + S[m(z)] \) on a von Neumann algebra A with the constraint Imm≥0. Here, z lies
    in the complex upper half-plane, a is a self-adjoint element of A and S is a positivity-preserving
    linear operator on A. We show that m is the Stieltjes transform of a compactly
    supported A-valued measure on R. Under suitable assumptions, we establish that
    this measure has a uniformly 1/3-Hölder continuous density with respect to the
    Lebesgue measure, which is supported on finitely many intervals, called bands.
    In fact, the density is analytic inside the bands with a square-root growth at
    the edges and internal cubic root cusps whenever the gap between two bands vanishes.
    The shape of these singularities is universal and no other singularity may occur.
    We give a precise asymptotic description of m near the singular points. These
    asymptotics generalize the analysis at the regular edges given in the companion
    paper on the Tracy-Widom universality for the edge eigenvalue statistics for correlated
    random matrices [the first author et al., Ann. Probab. 48, No. 2, 963--1001 (2020;
    Zbl 1434.60017)] and they play a key role in the proof of the Pearcey universality
    at the cusp for Wigner-type matrices [G. Cipolloni et al., Pure Appl. Anal. 1,
    No. 4, 615--707 (2019; Zbl 07142203); the second author et al., Commun. Math.
    Phys. 378, No. 2, 1203--1278 (2020; Zbl 07236118)]. We also extend the finite
    dimensional band mass formula from [the first author et al., loc. cit.] to the
    von Neumann algebra setting by showing that the spectral mass of the bands is
    topologically rigid under deformations and we conclude that these masses are quantized
    in some important cases.
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Johannes
  full_name: Alt, Johannes
  id: 36D3D8B6-F248-11E8-B48F-1D18A9856A87
  last_name: Alt
- first_name: László
  full_name: Erdös, László
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
- first_name: Torben H
  full_name: Krüger, Torben H
  id: 3020C786-F248-11E8-B48F-1D18A9856A87
  last_name: Krüger
  orcid: 0000-0002-4821-3297
citation:
  ama: 'Alt J, Erdös L, Krüger TH. The Dyson equation with linear self-energy: Spectral
    bands, edges and cusps. <i>Documenta Mathematica</i>. 2020;25:1421-1539. doi:<a
    href="https://doi.org/10.4171/dm/780">10.4171/dm/780</a>'
  apa: 'Alt, J., Erdös, L., &#38; Krüger, T. H. (2020). The Dyson equation with linear
    self-energy: Spectral bands, edges and cusps. <i>Documenta Mathematica</i>. EMS
    Press. <a href="https://doi.org/10.4171/dm/780">https://doi.org/10.4171/dm/780</a>'
  chicago: 'Alt, Johannes, László Erdös, and Torben H Krüger. “The Dyson Equation
    with Linear Self-Energy: Spectral Bands, Edges and Cusps.” <i>Documenta Mathematica</i>.
    EMS Press, 2020. <a href="https://doi.org/10.4171/dm/780">https://doi.org/10.4171/dm/780</a>.'
  ieee: 'J. Alt, L. Erdös, and T. H. Krüger, “The Dyson equation with linear self-energy:
    Spectral bands, edges and cusps,” <i>Documenta Mathematica</i>, vol. 25. EMS Press,
    pp. 1421–1539, 2020.'
  ista: 'Alt J, Erdös L, Krüger TH. 2020. The Dyson equation with linear self-energy:
    Spectral bands, edges and cusps. Documenta Mathematica. 25, 1421–1539.'
  mla: 'Alt, Johannes, et al. “The Dyson Equation with Linear Self-Energy: Spectral
    Bands, Edges and Cusps.” <i>Documenta Mathematica</i>, vol. 25, EMS Press, 2020,
    pp. 1421–539, doi:<a href="https://doi.org/10.4171/dm/780">10.4171/dm/780</a>.'
  short: J. Alt, L. Erdös, T.H. Krüger, Documenta Mathematica 25 (2020) 1421–1539.
corr_author: '1'
date_created: 2023-12-18T10:37:43Z
date_published: 2020-09-01T00:00:00Z
date_updated: 2025-04-15T08:05:00Z
day: '01'
ddc:
- '510'
department:
- _id: LaEr
doi: 10.4171/dm/780
external_id:
  arxiv:
  - '1804.07752'
file:
- access_level: open_access
  checksum: 12aacc1d63b852ff9a51c1f6b218d4a6
  content_type: application/pdf
  creator: dernst
  date_created: 2023-12-18T10:42:32Z
  date_updated: 2023-12-18T10:42:32Z
  file_id: '14695'
  file_name: 2020_DocumentaMathematica_Alt.pdf
  file_size: 1374708
  relation: main_file
  success: 1
file_date_updated: 2023-12-18T10:42:32Z
has_accepted_license: '1'
intvolume: '        25'
keyword:
- General Mathematics
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '09'
oa: 1
oa_version: Published Version
page: 1421-1539
publication: Documenta Mathematica
publication_identifier:
  eissn:
  - 1431-0643
  issn:
  - 1431-0635
publication_status: published
publisher: EMS Press
quality_controlled: '1'
related_material:
  record:
  - id: '6183'
    relation: earlier_version
    status: public
status: public
title: 'The Dyson equation with linear self-energy: Spectral bands, edges and cusps'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 25
year: '2020'
...
---
_id: '14891'
abstract:
- lang: eng
  text: We give the first mathematically rigorous justification of the local density
    approximation in density functional theory. We provide a quantitative estimate
    on the difference between the grand-canonical Levy–Lieb energy of a given density
    (the lowest possible energy of all quantum states having this density) and the
    integral over the uniform electron gas energy of this density. The error involves
    gradient terms and justifies the use of the local density approximation in the
    situation where the density is very flat on sufficiently large regions in space.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Mathieu
  full_name: Lewin, Mathieu
  last_name: Lewin
- first_name: Elliott H.
  full_name: Lieb, Elliott H.
  last_name: Lieb
- first_name: Robert
  full_name: Seiringer, Robert
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
citation:
  ama: Lewin M, Lieb EH, Seiringer R.  The local density approximation in density
    functional theory. <i>Pure and Applied Analysis</i>. 2020;2(1):35-73. doi:<a href="https://doi.org/10.2140/paa.2020.2.35">10.2140/paa.2020.2.35</a>
  apa: Lewin, M., Lieb, E. H., &#38; Seiringer, R. (2020).  The local density approximation
    in density functional theory. <i>Pure and Applied Analysis</i>. Mathematical Sciences
    Publishers. <a href="https://doi.org/10.2140/paa.2020.2.35">https://doi.org/10.2140/paa.2020.2.35</a>
  chicago: Lewin, Mathieu, Elliott H. Lieb, and Robert Seiringer. “ The Local Density
    Approximation in Density Functional Theory.” <i>Pure and Applied Analysis</i>.
    Mathematical Sciences Publishers, 2020. <a href="https://doi.org/10.2140/paa.2020.2.35">https://doi.org/10.2140/paa.2020.2.35</a>.
  ieee: M. Lewin, E. H. Lieb, and R. Seiringer, “ The local density approximation
    in density functional theory,” <i>Pure and Applied Analysis</i>, vol. 2, no. 1.
    Mathematical Sciences Publishers, pp. 35–73, 2020.
  ista: Lewin M, Lieb EH, Seiringer R. 2020.  The local density approximation in density
    functional theory. Pure and Applied Analysis. 2(1), 35–73.
  mla: Lewin, Mathieu, et al. “ The Local Density Approximation in Density Functional
    Theory.” <i>Pure and Applied Analysis</i>, vol. 2, no. 1, Mathematical Sciences
    Publishers, 2020, pp. 35–73, doi:<a href="https://doi.org/10.2140/paa.2020.2.35">10.2140/paa.2020.2.35</a>.
  short: M. Lewin, E.H. Lieb, R. Seiringer, Pure and Applied Analysis 2 (2020) 35–73.
corr_author: '1'
date_created: 2024-01-28T23:01:44Z
date_published: 2020-01-01T00:00:00Z
date_updated: 2024-10-09T21:08:02Z
day: '01'
department:
- _id: RoSe
doi: 10.2140/paa.2020.2.35
external_id:
  arxiv:
  - '1903.04046'
intvolume: '         2'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.1903.04046
month: '01'
oa: 1
oa_version: Preprint
page: 35-73
publication: Pure and Applied Analysis
publication_identifier:
  eissn:
  - 2578-5885
  issn:
  - 2578-5893
publication_status: published
publisher: Mathematical Sciences Publishers
quality_controlled: '1'
scopus_import: '1'
status: public
title: ' The local density approximation in density functional theory'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2
year: '2020'
...
---
_id: '15036'
abstract:
- lang: eng
  text: The assembly of a septin filament requires that homologous monomers must distinguish
    between one another in establishing appropriate interfaces with their neighbors.
    To understand this phenomenon at the molecular level, we present the first four
    crystal structures of heterodimeric septin complexes. We describe in detail the
    two distinct types of G-interface present within the octameric particles, which
    must polymerize to form filaments. These are formed between SEPT2 and SEPT6 and
    between SEPT7 and SEPT3, and their description permits an understanding of the
    structural basis for the selectivity necessary for correct filament assembly.
    By replacing SEPT6 by SEPT8 or SEPT11, it is possible to rationalize Kinoshita's
    postulate, which predicts the exchangeability of septins from within a subgroup.
    Switches I and II, which in classical small GTPases provide a mechanism for nucleotide-dependent
    conformational change, have been repurposed in septins to play a fundamental role
    in molecular recognition. Specifically, it is switch I which holds the key to
    discriminating between the two different G-interfaces. Moreover, residues which
    are characteristic for a given subgroup play subtle, but pivotal, roles in guaranteeing
    that the correct interfaces are formed.
article_processing_charge: No
article_type: original
author:
- first_name: Higor Vinícius Dias
  full_name: Rosa, Higor Vinícius Dias
  last_name: Rosa
- first_name: Diego Antonio
  full_name: Leonardo, Diego Antonio
  last_name: Leonardo
- first_name: Gabriel
  full_name: Brognara, Gabriel
  id: D96FFDA0-A884-11E9-9968-DC26E6697425
  last_name: Brognara
- first_name: José
  full_name: Brandão-Neto, José
  last_name: Brandão-Neto
- first_name: Humberto
  full_name: D'Muniz Pereira, Humberto
  last_name: D'Muniz Pereira
- first_name: Ana Paula Ulian
  full_name: Araújo, Ana Paula Ulian
  last_name: Araújo
- first_name: Richard Charles
  full_name: Garratt, Richard Charles
  last_name: Garratt
citation:
  ama: 'Rosa HVD, Leonardo DA, Brognara G, et al. Molecular recognition at septin
    interfaces: The switches hold the key. <i>Journal of Molecular Biology</i>. 2020;432(21):5784-5801.
    doi:<a href="https://doi.org/10.1016/j.jmb.2020.09.001">10.1016/j.jmb.2020.09.001</a>'
  apa: 'Rosa, H. V. D., Leonardo, D. A., Brognara, G., Brandão-Neto, J., D’Muniz Pereira,
    H., Araújo, A. P. U., &#38; Garratt, R. C. (2020). Molecular recognition at septin
    interfaces: The switches hold the key. <i>Journal of Molecular Biology</i>. Elsevier.
    <a href="https://doi.org/10.1016/j.jmb.2020.09.001">https://doi.org/10.1016/j.jmb.2020.09.001</a>'
  chicago: 'Rosa, Higor Vinícius Dias, Diego Antonio Leonardo, Gabriel Brognara, José
    Brandão-Neto, Humberto D’Muniz Pereira, Ana Paula Ulian Araújo, and Richard Charles
    Garratt. “Molecular Recognition at Septin Interfaces: The Switches Hold the Key.”
    <i>Journal of Molecular Biology</i>. Elsevier, 2020. <a href="https://doi.org/10.1016/j.jmb.2020.09.001">https://doi.org/10.1016/j.jmb.2020.09.001</a>.'
  ieee: 'H. V. D. Rosa <i>et al.</i>, “Molecular recognition at septin interfaces:
    The switches hold the key,” <i>Journal of Molecular Biology</i>, vol. 432, no.
    21. Elsevier, pp. 5784–5801, 2020.'
  ista: 'Rosa HVD, Leonardo DA, Brognara G, Brandão-Neto J, D’Muniz Pereira H, Araújo
    APU, Garratt RC. 2020. Molecular recognition at septin interfaces: The switches
    hold the key. Journal of Molecular Biology. 432(21), 5784–5801.'
  mla: 'Rosa, Higor Vinícius Dias, et al. “Molecular Recognition at Septin Interfaces:
    The Switches Hold the Key.” <i>Journal of Molecular Biology</i>, vol. 432, no.
    21, Elsevier, 2020, pp. 5784–801, doi:<a href="https://doi.org/10.1016/j.jmb.2020.09.001">10.1016/j.jmb.2020.09.001</a>.'
  short: H.V.D. Rosa, D.A. Leonardo, G. Brognara, J. Brandão-Neto, H. D’Muniz Pereira,
    A.P.U. Araújo, R.C. Garratt, Journal of Molecular Biology 432 (2020) 5784–5801.
date_created: 2024-02-28T08:50:34Z
date_published: 2020-10-02T00:00:00Z
date_updated: 2026-06-18T17:44:49Z
day: '02'
ddc:
- '570'
department:
- _id: MaLo
doi: 10.1016/j.jmb.2020.09.001
external_id:
  pmid:
  - '32910969'
intvolume: '       432'
issue: '21'
keyword:
- Molecular Biology
- Structural Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.jmb.2020.09.001
month: '10'
oa: 1
oa_version: Published Version
page: 5784-5801
pmid: 1
publication: Journal of Molecular Biology
publication_identifier:
  issn:
  - 0022-2836
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Molecular recognition at septin interfaces: The switches hold the key'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 432
year: '2020'
...
---
_id: '15037'
abstract:
- lang: eng
  text: Protein abundance and localization at the plasma membrane (PM) shapes plant
    development and mediates adaptation to changing environmental conditions. It is
    regulated by ubiquitination, a post-translational modification crucial for the
    proper sorting of endocytosed PM proteins to the vacuole for subsequent degradation.
    To understand the significance and the variety of roles played by this reversible
    modification, the function of ubiquitin receptors, which translate the ubiquitin
    signature into a cellular response, needs to be elucidated. In this study, we
    show that TOL (TOM1-like) proteins function in plants as multivalent ubiquitin
    receptors, governing ubiquitinated cargo delivery to the vacuole via the conserved
    Endosomal Sorting Complex Required for Transport (ESCRT) pathway. TOL2 and TOL6
    interact with components of the ESCRT machinery and bind to K63-linked ubiquitin
    via two tandemly arranged conserved ubiquitin-binding domains. Mutation of these
    domains results not only in a loss of ubiquitin binding but also altered localization,
    abolishing TOL6 ubiquitin receptor activity. Function and localization of TOL6
    is itself regulated by ubiquitination, whereby TOL6 ubiquitination potentially
    modulates degradation of PM-localized cargoes, assisting in the fine-tuning of
    the delicate interplay between protein recycling and downregulation. Taken together,
    our findings demonstrate the function and regulation of a ubiquitin receptor that
    mediates vacuolar degradation of PM proteins in higher plants.
article_processing_charge: No
article_type: original
author:
- first_name: Jeanette
  full_name: Moulinier-Anzola, Jeanette
  last_name: Moulinier-Anzola
- first_name: Maximilian
  full_name: Schwihla, Maximilian
  last_name: Schwihla
- first_name: Lucinda
  full_name: De-Araújo, Lucinda
  last_name: De-Araújo
- first_name: Christina
  full_name: Artner, Christina
  id: 45DF286A-F248-11E8-B48F-1D18A9856A87
  last_name: Artner
- first_name: Lisa
  full_name: Jörg, Lisa
  last_name: Jörg
- first_name: Nataliia
  full_name: Konstantinova, Nataliia
  last_name: Konstantinova
- first_name: Christian
  full_name: Luschnig, Christian
  last_name: Luschnig
- first_name: Barbara
  full_name: Korbei, Barbara
  last_name: Korbei
citation:
  ama: Moulinier-Anzola J, Schwihla M, De-Araújo L, et al. TOLs function as ubiquitin
    receptors in the early steps of the ESCRT pathway in higher plants. <i>Molecular
    Plant</i>. 2020;13(5):717-731. doi:<a href="https://doi.org/10.1016/j.molp.2020.02.012">10.1016/j.molp.2020.02.012</a>
  apa: Moulinier-Anzola, J., Schwihla, M., De-Araújo, L., Artner, C., Jörg, L., Konstantinova,
    N., … Korbei, B. (2020). TOLs function as ubiquitin receptors in the early steps
    of the ESCRT pathway in higher plants. <i>Molecular Plant</i>. Elsevier. <a href="https://doi.org/10.1016/j.molp.2020.02.012">https://doi.org/10.1016/j.molp.2020.02.012</a>
  chicago: Moulinier-Anzola, Jeanette, Maximilian Schwihla, Lucinda De-Araújo, Christina
    Artner, Lisa Jörg, Nataliia Konstantinova, Christian Luschnig, and Barbara Korbei.
    “TOLs Function as Ubiquitin Receptors in the Early Steps of the ESCRT Pathway
    in Higher Plants.” <i>Molecular Plant</i>. Elsevier, 2020. <a href="https://doi.org/10.1016/j.molp.2020.02.012">https://doi.org/10.1016/j.molp.2020.02.012</a>.
  ieee: J. Moulinier-Anzola <i>et al.</i>, “TOLs function as ubiquitin receptors in
    the early steps of the ESCRT pathway in higher plants,” <i>Molecular Plant</i>,
    vol. 13, no. 5. Elsevier, pp. 717–731, 2020.
  ista: Moulinier-Anzola J, Schwihla M, De-Araújo L, Artner C, Jörg L, Konstantinova
    N, Luschnig C, Korbei B. 2020. TOLs function as ubiquitin receptors in the early
    steps of the ESCRT pathway in higher plants. Molecular Plant. 13(5), 717–731.
  mla: Moulinier-Anzola, Jeanette, et al. “TOLs Function as Ubiquitin Receptors in
    the Early Steps of the ESCRT Pathway in Higher Plants.” <i>Molecular Plant</i>,
    vol. 13, no. 5, Elsevier, 2020, pp. 717–31, doi:<a href="https://doi.org/10.1016/j.molp.2020.02.012">10.1016/j.molp.2020.02.012</a>.
  short: J. Moulinier-Anzola, M. Schwihla, L. De-Araújo, C. Artner, L. Jörg, N. Konstantinova,
    C. Luschnig, B. Korbei, Molecular Plant 13 (2020) 717–731.
date_created: 2024-02-28T08:55:56Z
date_published: 2020-05-04T00:00:00Z
date_updated: 2024-02-28T12:41:52Z
day: '04'
ddc:
- '580'
department:
- _id: EvBe
doi: 10.1016/j.molp.2020.02.012
external_id:
  pmid:
  - '32087370'
file:
- access_level: open_access
  checksum: c538a5008f7827f62d17d40a3bfabe65
  content_type: application/pdf
  creator: dernst
  date_created: 2024-02-28T12:39:56Z
  date_updated: 2024-02-28T12:39:56Z
  file_id: '15038'
  file_name: 2020_MolecularPlant_MoulinierAnzola.pdf
  file_size: 3089212
  relation: main_file
  success: 1
file_date_updated: 2024-02-28T12:39:56Z
has_accepted_license: '1'
intvolume: '        13'
issue: '5'
keyword:
- Plant Science
- Molecular Biology
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 717-731
pmid: 1
publication: Molecular Plant
publication_identifier:
  issn:
  - 1674-2052
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: TOLs function as ubiquitin receptors in the early steps of the ESCRT pathway
  in higher plants
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2020'
...
---
_id: '15055'
abstract:
- lang: eng
  text: <jats:p>Markov decision processes (MDPs) are the defacto framework for sequential
    decision making in the presence of stochastic uncertainty. A classical optimization
    criterion for MDPs is to maximize the expected discounted-sum payoff, which ignores
    low probability catastrophic events with highly negative impact on the system.
    On the other hand, risk-averse policies require the probability of undesirable
    events to be below a given threshold, but they do not account for optimization
    of the expected payoff. We consider MDPs with discounted-sum payoff with failure
    states which represent catastrophic outcomes. The objective of risk-constrained
    planning is to maximize the expected discounted-sum payoff among risk-averse policies
    that ensure the probability to encounter a failure state is below a desired threshold.
    Our main contribution is an efficient risk-constrained planning algorithm that
    combines UCT-like search with a predictor learned through interaction with the
    MDP (in the style of AlphaZero) and with a risk-constrained action selection via
    linear programming. We demonstrate the effectiveness of our approach with experiments
    on classical MDPs from the literature, including benchmarks with an order of 106
    states.</jats:p>
acknowledgement: Krishnendu Chatterjee is supported by the Austrian Science Fund (FWF)
  NFN Grant No. S11407-N23 (RiSE/SHiNE), and COST Action GAMENET. Tomas Brazdil is
  supported by the Grant Agency of Masaryk University grant no. MUNI/G/0739/2017 and
  by the Czech Science Foundation grant No. 18-11193S. Petr Novotny and Jirı Vahala
  are supported by the Czech Science Foundation grant No. GJ19-15134Y.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Tomáš
  full_name: Brázdil, Tomáš
  last_name: Brázdil
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Petr
  full_name: Novotný, Petr
  last_name: Novotný
- first_name: Jiří
  full_name: Vahala, Jiří
  last_name: Vahala
citation:
  ama: Brázdil T, Chatterjee K, Novotný P, Vahala J. Reinforcement learning of risk-constrained
    policies in Markov decision processes. <i>Proceedings of the 34th AAAI Conference
    on Artificial Intelligence</i>. 2020;34(06):9794-9801. doi:<a href="https://doi.org/10.1609/aaai.v34i06.6531">10.1609/aaai.v34i06.6531</a>
  apa: 'Brázdil, T., Chatterjee, K., Novotný, P., &#38; Vahala, J. (2020). Reinforcement
    learning of risk-constrained policies in Markov decision processes. <i>Proceedings
    of the 34th AAAI Conference on Artificial Intelligence</i>. New York, NY, United
    States: Association for the Advancement of Artificial Intelligence. <a href="https://doi.org/10.1609/aaai.v34i06.6531">https://doi.org/10.1609/aaai.v34i06.6531</a>'
  chicago: Brázdil, Tomáš, Krishnendu Chatterjee, Petr Novotný, and Jiří Vahala. “Reinforcement
    Learning of Risk-Constrained Policies in Markov Decision Processes.” <i>Proceedings
    of the 34th AAAI Conference on Artificial Intelligence</i>. Association for the
    Advancement of Artificial Intelligence, 2020. <a href="https://doi.org/10.1609/aaai.v34i06.6531">https://doi.org/10.1609/aaai.v34i06.6531</a>.
  ieee: T. Brázdil, K. Chatterjee, P. Novotný, and J. Vahala, “Reinforcement learning
    of risk-constrained policies in Markov decision processes,” <i>Proceedings of
    the 34th AAAI Conference on Artificial Intelligence</i>, vol. 34, no. 06. Association
    for the Advancement of Artificial Intelligence, pp. 9794–9801, 2020.
  ista: Brázdil T, Chatterjee K, Novotný P, Vahala J. 2020. Reinforcement learning
    of risk-constrained policies in Markov decision processes. Proceedings of the
    34th AAAI Conference on Artificial Intelligence. 34(06), 9794–9801.
  mla: Brázdil, Tomáš, et al. “Reinforcement Learning of Risk-Constrained Policies
    in Markov Decision Processes.” <i>Proceedings of the 34th AAAI Conference on Artificial
    Intelligence</i>, vol. 34, no. 06, Association for the Advancement of Artificial
    Intelligence, 2020, pp. 9794–801, doi:<a href="https://doi.org/10.1609/aaai.v34i06.6531">10.1609/aaai.v34i06.6531</a>.
  short: T. Brázdil, K. Chatterjee, P. Novotný, J. Vahala, Proceedings of the 34th
    AAAI Conference on Artificial Intelligence 34 (2020) 9794–9801.
conference:
  end_date: 2020-02-12
  location: New York, NY, United States
  name: 'AAAI: Conference on Artificial Intelligence'
  start_date: 2020-02-07
date_created: 2024-03-04T08:07:22Z
date_published: 2020-04-03T00:00:00Z
date_updated: 2025-04-15T06:30:08Z
day: '03'
department:
- _id: KrCh
doi: 10.1609/aaai.v34i06.6531
external_id:
  arxiv:
  - '2002.12086'
intvolume: '        34'
issue: '06'
keyword:
- General Medicine
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2002.12086
month: '04'
oa: 1
oa_version: Preprint
page: 9794-9801
project:
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S11407
  name: Game Theory
publication: Proceedings of the 34th AAAI Conference on Artificial Intelligence
publication_identifier:
  issn:
  - 2374-3468
publication_status: published
publisher: Association for the Advancement of Artificial Intelligence
quality_controlled: '1'
status: public
title: Reinforcement learning of risk-constrained policies in Markov decision processes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 34
year: '2020'
...
---
_id: '15057'
abstract:
- lang: eng
  text: Vaccinia virus–related kinase (VRK) is an evolutionarily conserved nuclear
    protein kinase. VRK-1, the single Caenorhabditis elegans VRK ortholog, functions
    in cell division and germline proliferation. However, the role of VRK-1 in postmitotic
    cells and adult life span remains unknown. Here, we show that VRK-1 increases
    organismal longevity by activating the cellular energy sensor, AMP-activated protein
    kinase (AMPK), via direct phosphorylation. We found that overexpression of vrk-1
    in the soma of adult C. elegans increased life span and, conversely, inhibition
    of vrk-1 decreased life span. In addition, vrk-1 was required for longevity conferred
    by mutations that inhibit C. elegans mitochondrial respiration, which requires
    AMPK. VRK-1 directly phosphorylated and up-regulated AMPK in both C. elegans and
    cultured human cells. Thus, our data show that the somatic nuclear kinase, VRK-1,
    promotes longevity through AMPK activation, and this function appears to be conserved
    between C. elegans and humans.
acknowledgement: 'This research was supported by grants NRF-2019R1A3B2067745 and NRF-2017R1A5A1015366
  funded by the Korean Government (MSIT) through the National Research Foundation
  (NRF) of Korea to S.-J.V.L. and by grant Basic Science Research Program (No. 2019R1A2C2009440)
  funded by the Korean Government (MSIT) through the NRF of Korea to K.-T.K. '
article_number: aaw7824
article_processing_charge: No
article_type: original
author:
- first_name: Sangsoon
  full_name: Park, Sangsoon
  last_name: Park
- first_name: Murat
  full_name: Artan, Murat
  id: C407B586-6052-11E9-B3AE-7006E6697425
  last_name: Artan
  orcid: 0000-0001-8945-6992
- first_name: Seung Hyun
  full_name: Han, Seung Hyun
  last_name: Han
- first_name: Hae-Eun H.
  full_name: Park, Hae-Eun H.
  last_name: Park
- first_name: Yoonji
  full_name: Jung, Yoonji
  last_name: Jung
- first_name: Ara B.
  full_name: Hwang, Ara B.
  last_name: Hwang
- first_name: Won Sik
  full_name: Shin, Won Sik
  last_name: Shin
- first_name: Kyong-Tai
  full_name: Kim, Kyong-Tai
  last_name: Kim
- first_name: Seung-Jae V.
  full_name: Lee, Seung-Jae V.
  last_name: Lee
citation:
  ama: Park S, Artan M, Han SH, et al. VRK-1 extends life span by activation of AMPK
    via phosphorylation. <i>Science Advances</i>. 2020;6(27). doi:<a href="https://doi.org/10.1126/sciadv.aaw7824">10.1126/sciadv.aaw7824</a>
  apa: Park, S., Artan, M., Han, S. H., Park, H.-E. H., Jung, Y., Hwang, A. B., …
    Lee, S.-J. V. (2020). VRK-1 extends life span by activation of AMPK via phosphorylation.
    <i>Science Advances</i>. American Association for the Advancement of Science.
    <a href="https://doi.org/10.1126/sciadv.aaw7824">https://doi.org/10.1126/sciadv.aaw7824</a>
  chicago: Park, Sangsoon, Murat Artan, Seung Hyun Han, Hae-Eun H. Park, Yoonji Jung,
    Ara B. Hwang, Won Sik Shin, Kyong-Tai Kim, and Seung-Jae V. Lee. “VRK-1 Extends
    Life Span by Activation of AMPK via Phosphorylation.” <i>Science Advances</i>.
    American Association for the Advancement of Science, 2020. <a href="https://doi.org/10.1126/sciadv.aaw7824">https://doi.org/10.1126/sciadv.aaw7824</a>.
  ieee: S. Park <i>et al.</i>, “VRK-1 extends life span by activation of AMPK via
    phosphorylation,” <i>Science Advances</i>, vol. 6, no. 27. American Association
    for the Advancement of Science, 2020.
  ista: Park S, Artan M, Han SH, Park H-EH, Jung Y, Hwang AB, Shin WS, Kim K-T, Lee
    S-JV. 2020. VRK-1 extends life span by activation of AMPK via phosphorylation.
    Science Advances. 6(27), aaw7824.
  mla: Park, Sangsoon, et al. “VRK-1 Extends Life Span by Activation of AMPK via Phosphorylation.”
    <i>Science Advances</i>, vol. 6, no. 27, aaw7824, American Association for the
    Advancement of Science, 2020, doi:<a href="https://doi.org/10.1126/sciadv.aaw7824">10.1126/sciadv.aaw7824</a>.
  short: S. Park, M. Artan, S.H. Han, H.-E.H. Park, Y. Jung, A.B. Hwang, W.S. Shin,
    K.-T. Kim, S.-J.V. Lee, Science Advances 6 (2020).
date_created: 2024-03-04T09:41:57Z
date_published: 2020-07-01T00:00:00Z
date_updated: 2024-03-04T09:52:09Z
day: '01'
ddc:
- '570'
department:
- _id: MaDe
doi: 10.1126/sciadv.aaw7824
file:
- access_level: open_access
  checksum: a37157cd0de709dce5fe03f4a31cd0b6
  content_type: application/pdf
  creator: dernst
  date_created: 2024-03-04T09:46:41Z
  date_updated: 2024-03-04T09:46:41Z
  file_id: '15058'
  file_name: 2020_ScienceAdvances_Park.pdf
  file_size: 1864415
  relation: main_file
  success: 1
file_date_updated: 2024-03-04T09:46:41Z
has_accepted_license: '1'
intvolume: '         6'
issue: '27'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '07'
oa: 1
oa_version: Published Version
publication: Science Advances
publication_identifier:
  eissn:
  - 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
status: public
title: VRK-1 extends life span by activation of AMPK via phosphorylation
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2020'
...
---
_id: '15059'
abstract:
- lang: eng
  text: "In this paper we present a room temperature radiometer that can eliminate
    the need of using cryostats in satellite payload reducing its weight and improving
    reliability. The proposed radiometer is based on an electro-optic upconverter
    that boosts up microwave photons energy by upconverting them into an optical domain
    what makes them immune to thermal noise even if operating at room temperature.
    The converter uses a high-quality factor whispering gallery\r\nmode (WGM) resonator
    providing naturally narrow bandwidth and therefore might be useful for applications
    like microwave hyperspectral sensing. The upconversion process is explained by\r\nproviding
    essential information about photon conversion efficiency and sensitivity. To prove
    the concept, we describe an experiment which shows state-of-the-art photon conversion
    efficiency n=10-5 per mW of pump power at the frequency of 80 GHz."
acknowledgement: This work has been financially supported by Comunidad de Madrid S2018/NMT-4333
  ARTINLARA-CM projects, and “FUNDACIÓN SENER” REFTA projects.
article_processing_charge: No
author:
- first_name: Michal
  full_name: Wasiak, Michal
  last_name: Wasiak
- first_name: Gabriel Santamaria
  full_name: Botello, Gabriel Santamaria
  last_name: Botello
- first_name: Kerlos Atia
  full_name: Abdalmalak, Kerlos Atia
  last_name: Abdalmalak
- first_name: Florian
  full_name: Sedlmeir, Florian
  last_name: Sedlmeir
- first_name: Alfredo R
  full_name: Rueda Sanchez, Alfredo R
  id: 3B82B0F8-F248-11E8-B48F-1D18A9856A87
  last_name: Rueda Sanchez
  orcid: 0000-0001-6249-5860
- first_name: Daniel
  full_name: Segovia-Vargas, Daniel
  last_name: Segovia-Vargas
- first_name: Harald G. L.
  full_name: Schwefel, Harald G. L.
  last_name: Schwefel
- first_name: Luis Enrique Garcia
  full_name: Munoz, Luis Enrique Garcia
  last_name: Munoz
citation:
  ama: 'Wasiak M, Botello GS, Abdalmalak KA, et al. Compact millimeter and submillimeter-wave
    photonic radiometer for cubesats. In: <i>14th European Conference on Antennas
    and Propagation</i>. IEEE; 2020. doi:<a href="https://doi.org/10.23919/eucap48036.2020.9135962">10.23919/eucap48036.2020.9135962</a>'
  apa: 'Wasiak, M., Botello, G. S., Abdalmalak, K. A., Sedlmeir, F., Rueda Sanchez,
    A. R., Segovia-Vargas, D., … Munoz, L. E. G. (2020). Compact millimeter and submillimeter-wave
    photonic radiometer for cubesats. In <i>14th European Conference on Antennas and
    Propagation</i>. Copenhagen, Denmark: IEEE. <a href="https://doi.org/10.23919/eucap48036.2020.9135962">https://doi.org/10.23919/eucap48036.2020.9135962</a>'
  chicago: Wasiak, Michal, Gabriel Santamaria Botello, Kerlos Atia Abdalmalak, Florian
    Sedlmeir, Alfredo R Rueda Sanchez, Daniel Segovia-Vargas, Harald G. L. Schwefel,
    and Luis Enrique Garcia Munoz. “Compact Millimeter and Submillimeter-Wave Photonic
    Radiometer for Cubesats.” In <i>14th European Conference on Antennas and Propagation</i>.
    IEEE, 2020. <a href="https://doi.org/10.23919/eucap48036.2020.9135962">https://doi.org/10.23919/eucap48036.2020.9135962</a>.
  ieee: M. Wasiak <i>et al.</i>, “Compact millimeter and submillimeter-wave photonic
    radiometer for cubesats,” in <i>14th European Conference on Antennas and Propagation</i>,
    Copenhagen, Denmark, 2020.
  ista: 'Wasiak M, Botello GS, Abdalmalak KA, Sedlmeir F, Rueda Sanchez AR, Segovia-Vargas
    D, Schwefel HGL, Munoz LEG. 2020. Compact millimeter and submillimeter-wave photonic
    radiometer for cubesats. 14th European Conference on Antennas and Propagation.
    EuCAP: European Conference on Antennas and Propagation.'
  mla: Wasiak, Michal, et al. “Compact Millimeter and Submillimeter-Wave Photonic
    Radiometer for Cubesats.” <i>14th European Conference on Antennas and Propagation</i>,
    IEEE, 2020, doi:<a href="https://doi.org/10.23919/eucap48036.2020.9135962">10.23919/eucap48036.2020.9135962</a>.
  short: M. Wasiak, G.S. Botello, K.A. Abdalmalak, F. Sedlmeir, A.R. Rueda Sanchez,
    D. Segovia-Vargas, H.G.L. Schwefel, L.E.G. Munoz, in:, 14th European Conference
    on Antennas and Propagation, IEEE, 2020.
conference:
  end_date: 2020-03-20
  location: Copenhagen, Denmark
  name: 'EuCAP: European Conference on Antennas and Propagation'
  start_date: 2020-03-15
date_created: 2024-03-04T09:57:48Z
date_published: 2020-07-08T00:00:00Z
date_updated: 2024-03-04T10:02:49Z
day: '08'
department:
- _id: JoFi
doi: 10.23919/eucap48036.2020.9135962
language:
- iso: eng
month: '07'
oa_version: None
publication: 14th European Conference on Antennas and Propagation
publication_identifier:
  eisbn:
  - '9788831299008'
publication_status: published
publisher: IEEE
quality_controlled: '1'
status: public
title: Compact millimeter and submillimeter-wave photonic radiometer for cubesats
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '15061'
abstract:
- lang: eng
  text: The actin cytoskeleton, a dynamic network of actin filaments and associated
    F-actin–binding proteins, is fundamentally important in eukaryotes. α-Actinins
    are major F-actin bundlers that are inhibited by Ca2+ in nonmuscle cells. Here
    we report the mechanism of Ca2+-mediated regulation of Entamoeba histolytica α-actinin-2
    (EhActn2) with features expected for the common ancestor of Entamoeba and higher
    eukaryotic α-actinins. Crystal structures of Ca2+-free and Ca2+-bound EhActn2
    reveal a calmodulin-like domain (CaMD) uniquely inserted within the rod domain.
    Integrative studies reveal an exceptionally high affinity of the EhActn2 CaMD
    for Ca2+, binding of which can only be regulated in the presence of physiological
    concentrations of Mg2+. Ca2+ binding triggers an increase in protein multidomain
    rigidity, reducing conformational flexibility of F-actin–binding domains via interdomain
    cross-talk and consequently inhibiting F-actin bundling. In vivo studies uncover
    that EhActn2 plays an important role in phagocytic cup formation and might constitute
    a new drug target for amoebic dysentery.
acknowledged_ssus:
- _id: LifeSc
acknowledgement: "We thank the staff of the macromolecular crystallography (MX) and
  SAXS beamlines at the European Synchrotron Radiation facility, Diamond, and Swiss
  Light Source for excellent support, and the Life Sciences Facility of the Institute
  of Science and Technology Austria for usage of the rheometer. We thank Life Sciences
  editors for editing assistance. EM data were\r\nrecorded at the EM Facility of the
  Vienna BioCenter Core Facilities (Austria). Confocal microscopy was carried out
  at the Advanced Instrument Research Facility, Jawaharlal Nehru University. K.D.-C.’s
  research was supported by the Initial Training Network MUZIC (ITN-MUZIC) (N°238423),
  Austrian Science Fund (FWF) Projects I525, I1593, P22276, P19060, and W1221, Laura
  Bassi Centre of Optimized Structural Studies (N°253275), a Wellcome Trust Collaborative
  Award (201543/Z/16/Z), COST Action BM1405, Vienna Science and Technology Fund (WWTF)
  Chemical Biology Project LS17-008, and Christian Doppler Laboratory for High-Content
  Structural Biology and Biotechnology. K.Z., J.L.A., C.S., E.A.G., and A.S. were
  supported by the University of Vienna, J.K. by a Wellcome Trust Collaborative Award
  and by the Centre of Optimized Structural Studies, M.P. by FWF Project I1593, E.d.A.R.
  ITN-MUZIC, and FWF Projects I525 and I1593, and T.C.M. and L.C. by FWF Project I
  2408-B22. E.A.G. acknowledges the PhD program Structure and Interaction of Biological
  Macromolecules. M.B. acknowledges the University Grant Commission, India, for a
  senior research fellowship. A.B. acknowledges a JC Bose Fellowship from the Science
  Engineering Research Council. "
article_processing_charge: No
article_type: original
author:
- first_name: Nikos
  full_name: Pinotsis, Nikos
  last_name: Pinotsis
- first_name: Karolina
  full_name: Zielinska, Karolina
  last_name: Zielinska
- first_name: Mrigya
  full_name: Babuta, Mrigya
  last_name: Babuta
- first_name: Joan L.
  full_name: Arolas, Joan L.
  last_name: Arolas
- first_name: Julius
  full_name: Kostan, Julius
  last_name: Kostan
- first_name: Muhammad Bashir
  full_name: Khan, Muhammad Bashir
  last_name: Khan
- first_name: Claudia
  full_name: Schreiner, Claudia
  last_name: Schreiner
- first_name: Anita P
  full_name: Testa Salmazo, Anita P
  id: 41F1F098-F248-11E8-B48F-1D18A9856A87
  last_name: Testa Salmazo
- first_name: Luciano
  full_name: Ciccarelli, Luciano
  last_name: Ciccarelli
- first_name: Martin
  full_name: Puchinger, Martin
  last_name: Puchinger
- first_name: Eirini A.
  full_name: Gkougkoulia, Eirini A.
  last_name: Gkougkoulia
- first_name: Euripedes de Almeida
  full_name: Ribeiro, Euripedes de Almeida
  last_name: Ribeiro
- first_name: Thomas C.
  full_name: Marlovits, Thomas C.
  last_name: Marlovits
- first_name: Alok
  full_name: Bhattacharya, Alok
  last_name: Bhattacharya
- first_name: Kristina
  full_name: Djinovic-Carugo, Kristina
  last_name: Djinovic-Carugo
citation:
  ama: Pinotsis N, Zielinska K, Babuta M, et al. Calcium modulates the domain flexibility
    and function of an α-actinin similar to the ancestral α-actinin. <i>Proceedings
    of the National Academy of Sciences of the United States of America</i>. 2020;117(36):22101-22112.
    doi:<a href="https://doi.org/10.1073/pnas.1917269117">10.1073/pnas.1917269117</a>
  apa: Pinotsis, N., Zielinska, K., Babuta, M., Arolas, J. L., Kostan, J., Khan, M.
    B., … Djinovic-Carugo, K. (2020). Calcium modulates the domain flexibility and
    function of an α-actinin similar to the ancestral α-actinin. <i>Proceedings of
    the National Academy of Sciences of the United States of America</i>. National
    Academy of Sciences. <a href="https://doi.org/10.1073/pnas.1917269117">https://doi.org/10.1073/pnas.1917269117</a>
  chicago: Pinotsis, Nikos, Karolina Zielinska, Mrigya Babuta, Joan L. Arolas, Julius
    Kostan, Muhammad Bashir Khan, Claudia Schreiner, et al. “Calcium Modulates the
    Domain Flexibility and Function of an α-Actinin Similar to the Ancestral α-Actinin.”
    <i>Proceedings of the National Academy of Sciences of the United States of America</i>.
    National Academy of Sciences, 2020. <a href="https://doi.org/10.1073/pnas.1917269117">https://doi.org/10.1073/pnas.1917269117</a>.
  ieee: N. Pinotsis <i>et al.</i>, “Calcium modulates the domain flexibility and function
    of an α-actinin similar to the ancestral α-actinin,” <i>Proceedings of the National
    Academy of Sciences of the United States of America</i>, vol. 117, no. 36. National
    Academy of Sciences, pp. 22101–22112, 2020.
  ista: Pinotsis N, Zielinska K, Babuta M, Arolas JL, Kostan J, Khan MB, Schreiner
    C, Testa Salmazo AP, Ciccarelli L, Puchinger M, Gkougkoulia EA, Ribeiro E de A,
    Marlovits TC, Bhattacharya A, Djinovic-Carugo K. 2020. Calcium modulates the domain
    flexibility and function of an α-actinin similar to the ancestral α-actinin. Proceedings
    of the National Academy of Sciences of the United States of America. 117(36),
    22101–22112.
  mla: Pinotsis, Nikos, et al. “Calcium Modulates the Domain Flexibility and Function
    of an α-Actinin Similar to the Ancestral α-Actinin.” <i>Proceedings of the National
    Academy of Sciences of the United States of America</i>, vol. 117, no. 36, National
    Academy of Sciences, 2020, pp. 22101–12, doi:<a href="https://doi.org/10.1073/pnas.1917269117">10.1073/pnas.1917269117</a>.
  short: N. Pinotsis, K. Zielinska, M. Babuta, J.L. Arolas, J. Kostan, M.B. Khan,
    C. Schreiner, A.P. Testa Salmazo, L. Ciccarelli, M. Puchinger, E.A. Gkougkoulia,
    E. de A. Ribeiro, T.C. Marlovits, A. Bhattacharya, K. Djinovic-Carugo, Proceedings
    of the National Academy of Sciences of the United States of America 117 (2020)
    22101–22112.
date_created: 2024-03-04T10:03:52Z
date_published: 2020-09-08T00:00:00Z
date_updated: 2026-06-18T17:45:21Z
day: '08'
ddc:
- '570'
department:
- _id: CaBe
doi: 10.1073/pnas.1917269117
external_id:
  pmid:
  - '32848067'
intvolume: '       117'
issue: '36'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1073/pnas.191726911
month: '09'
oa: 1
oa_version: Published Version
page: 22101-22112
pmid: 1
publication: Proceedings of the National Academy of Sciences of the United States
  of America
publication_identifier:
  eissn:
  - 1091-6490
  issn:
  - 0027-8424
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
status: public
title: Calcium modulates the domain flexibility and function of an α-actinin similar
  to the ancestral α-actinin
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 117
year: '2020'
...
---
_id: '15063'
abstract:
- lang: eng
  text: We consider the least singular value of a large random matrix with real or
    complex i.i.d. Gaussian entries shifted by a constant z∈C. We prove an optimal
    lower tail estimate on this singular value in the critical regime where z is around
    the spectral edge, thus improving the classical bound of Sankar, Spielman and
    Teng (SIAM J. Matrix Anal. Appl. 28:2 (2006), 446–476) for the particular shift-perturbation
    in the edge regime. Lacking Brézin–Hikami formulas in the real case, we rely on
    the superbosonization formula (Comm. Math. Phys. 283:2 (2008), 343–395).
acknowledgement: Partially supported by ERC Advanced Grant No. 338804. This project
  has received funding from the European Union’s Horizon 2020 research and innovation
  programme under the Marie Sklodowska-Curie Grant Agreement No. 66538
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Giorgio
  full_name: Cipolloni, Giorgio
  id: 42198EFA-F248-11E8-B48F-1D18A9856A87
  last_name: Cipolloni
  orcid: 0000-0002-4901-7992
- first_name: László
  full_name: Erdös, László
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
- first_name: Dominik J
  full_name: Schröder, Dominik J
  id: 408ED176-F248-11E8-B48F-1D18A9856A87
  last_name: Schröder
  orcid: 0000-0002-2904-1856
citation:
  ama: Cipolloni G, Erdös L, Schröder DJ. Optimal lower bound on the least singular
    value of the shifted Ginibre ensemble. <i>Probability and Mathematical Physics</i>.
    2020;1(1):101-146. doi:<a href="https://doi.org/10.2140/pmp.2020.1.101">10.2140/pmp.2020.1.101</a>
  apa: Cipolloni, G., Erdös, L., &#38; Schröder, D. J. (2020). Optimal lower bound
    on the least singular value of the shifted Ginibre ensemble. <i>Probability and
    Mathematical Physics</i>. Mathematical Sciences Publishers. <a href="https://doi.org/10.2140/pmp.2020.1.101">https://doi.org/10.2140/pmp.2020.1.101</a>
  chicago: Cipolloni, Giorgio, László Erdös, and Dominik J Schröder. “Optimal Lower
    Bound on the Least Singular Value of the Shifted Ginibre Ensemble.” <i>Probability
    and Mathematical Physics</i>. Mathematical Sciences Publishers, 2020. <a href="https://doi.org/10.2140/pmp.2020.1.101">https://doi.org/10.2140/pmp.2020.1.101</a>.
  ieee: G. Cipolloni, L. Erdös, and D. J. Schröder, “Optimal lower bound on the least
    singular value of the shifted Ginibre ensemble,” <i>Probability and Mathematical
    Physics</i>, vol. 1, no. 1. Mathematical Sciences Publishers, pp. 101–146, 2020.
  ista: Cipolloni G, Erdös L, Schröder DJ. 2020. Optimal lower bound on the least
    singular value of the shifted Ginibre ensemble. Probability and Mathematical Physics.
    1(1), 101–146.
  mla: Cipolloni, Giorgio, et al. “Optimal Lower Bound on the Least Singular Value
    of the Shifted Ginibre Ensemble.” <i>Probability and Mathematical Physics</i>,
    vol. 1, no. 1, Mathematical Sciences Publishers, 2020, pp. 101–46, doi:<a href="https://doi.org/10.2140/pmp.2020.1.101">10.2140/pmp.2020.1.101</a>.
  short: G. Cipolloni, L. Erdös, D.J. Schröder, Probability and Mathematical Physics
    1 (2020) 101–146.
corr_author: '1'
date_created: 2024-03-04T10:27:57Z
date_published: 2020-11-16T00:00:00Z
date_updated: 2025-07-10T11:51:06Z
day: '16'
department:
- _id: LaEr
doi: 10.2140/pmp.2020.1.101
ec_funded: 1
external_id:
  arxiv:
  - '1908.01653'
intvolume: '         1'
issue: '1'
keyword:
- General Medicine
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.1908.01653
month: '11'
oa: 1
oa_version: Preprint
page: 101-146
project:
- _id: 258DCDE6-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '338804'
  name: Random matrices, universality and disordered quantum systems
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication: Probability and Mathematical Physics
publication_identifier:
  issn:
  - 2690-0998
publication_status: published
publisher: Mathematical Sciences Publishers
quality_controlled: '1'
scopus_import: '1'
status: public
title: Optimal lower bound on the least singular value of the shifted Ginibre ensemble
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1
year: '2020'
...
---
_id: '15064'
abstract:
- lang: eng
  text: We call a continuous self-map that reveals itself through a discrete set of
    point-value pairs a sampled dynamical system. Capturing the available information
    with chain maps on Delaunay complexes, we use persistent homology to quantify
    the evidence of recurrent behavior. We establish a sampling theorem to recover
    the eigenspaces of the endomorphism on homology induced by the self-map. Using
    a combinatorial gradient flow arising from the discrete Morse theory for Čech
    and Delaunay complexes, we construct a chain map to transform the problem from
    the natural but expensive Čech complexes to the computationally efficient Delaunay
    triangulations. The fast chain map algorithm has applications beyond dynamical
    systems.
acknowledgement: This research has been supported by the DFG Collaborative Research
  Center SFB/TRR 109 “Discretization in Geometry and Dynamics”, by Polish MNiSzW Grant
  No. 2621/7.PR/12/2013/2, by the Polish National Science Center under Maestro Grant
  No. 2014/14/A/ST1/00453 and Grant No. DEC-2013/09/N/ST6/02995. Open Access funding
  provided by Projekt DEAL.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: U.
  full_name: Bauer, U.
  last_name: Bauer
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Grzegorz
  full_name: Jablonski, Grzegorz
  id: 4483EF78-F248-11E8-B48F-1D18A9856A87
  last_name: Jablonski
  orcid: 0000-0002-3536-9866
- first_name: M.
  full_name: Mrozek, M.
  last_name: Mrozek
citation:
  ama: Bauer U, Edelsbrunner H, Jablonski G, Mrozek M. Čech-Delaunay gradient flow
    and homology inference for self-maps. <i>Journal of Applied and Computational
    Topology</i>. 2020;4(4):455-480. doi:<a href="https://doi.org/10.1007/s41468-020-00058-8">10.1007/s41468-020-00058-8</a>
  apa: Bauer, U., Edelsbrunner, H., Jablonski, G., &#38; Mrozek, M. (2020). Čech-Delaunay
    gradient flow and homology inference for self-maps. <i>Journal of Applied and
    Computational Topology</i>. Springer Nature. <a href="https://doi.org/10.1007/s41468-020-00058-8">https://doi.org/10.1007/s41468-020-00058-8</a>
  chicago: Bauer, U., Herbert Edelsbrunner, Grzegorz Jablonski, and M. Mrozek. “Čech-Delaunay
    Gradient Flow and Homology Inference for Self-Maps.” <i>Journal of Applied and
    Computational Topology</i>. Springer Nature, 2020. <a href="https://doi.org/10.1007/s41468-020-00058-8">https://doi.org/10.1007/s41468-020-00058-8</a>.
  ieee: U. Bauer, H. Edelsbrunner, G. Jablonski, and M. Mrozek, “Čech-Delaunay gradient
    flow and homology inference for self-maps,” <i>Journal of Applied and Computational
    Topology</i>, vol. 4, no. 4. Springer Nature, pp. 455–480, 2020.
  ista: Bauer U, Edelsbrunner H, Jablonski G, Mrozek M. 2020. Čech-Delaunay gradient
    flow and homology inference for self-maps. Journal of Applied and Computational
    Topology. 4(4), 455–480.
  mla: Bauer, U., et al. “Čech-Delaunay Gradient Flow and Homology Inference for Self-Maps.”
    <i>Journal of Applied and Computational Topology</i>, vol. 4, no. 4, Springer
    Nature, 2020, pp. 455–80, doi:<a href="https://doi.org/10.1007/s41468-020-00058-8">10.1007/s41468-020-00058-8</a>.
  short: U. Bauer, H. Edelsbrunner, G. Jablonski, M. Mrozek, Journal of Applied and
    Computational Topology 4 (2020) 455–480.
date_created: 2024-03-04T10:47:49Z
date_published: 2020-12-01T00:00:00Z
date_updated: 2024-03-04T10:54:04Z
day: '01'
ddc:
- '500'
department:
- _id: HeEd
doi: 10.1007/s41468-020-00058-8
file:
- access_level: open_access
  checksum: eed1168b6e66cd55272c19bb7fca8a1c
  content_type: application/pdf
  creator: dernst
  date_created: 2024-03-04T10:52:42Z
  date_updated: 2024-03-04T10:52:42Z
  file_id: '15065'
  file_name: 2020_JourApplCompTopology_Bauer.pdf
  file_size: 851190
  relation: main_file
  success: 1
file_date_updated: 2024-03-04T10:52:42Z
has_accepted_license: '1'
intvolume: '         4'
issue: '4'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 455-480
publication: Journal of Applied and Computational Topology
publication_identifier:
  eissn:
  - 2367-1734
  issn:
  - 2367-1726
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Čech-Delaunay gradient flow and homology inference for self-maps
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2020'
...
---
_id: '15071'
abstract:
- lang: eng
  text: "A mesophilic methanogenic culture, designated JL01, was isolated from Holocene
    permafrost in the Russian Arctic [1]. After long-term extensive cultivation at
    15°C it turned out to be a tied binary culture of archaeal (JL01) and bacterial
    (Sphaerochaeta associata GLS2) strains.\r\nStrain JL01 was a strict anaerobe and
    grew on methanol, acetate and methylamines as energy and carbon sources. Cells
    were irregular coccoid, non-motile, non-spore-forming, and Gram-stainpositive.
    Optimum conditions for growth were 24-28 oC, pH 6.8–7.3 and 0.075-0.1 M NaCl.\r\nPhylogenetic
    tree reconstructions based on 16S rRNA and concatenated alignment of broadly\r\nconserved
    protein-coding genes revealed its close relation to Methanosarcina mazei S-6\r\nT
    (similarity 99.5%). The comparison of whole genomic sequences (ANI) of the isolate
    and the type strain of M.mazei was 98.5%, which is higher than the values recommended
    for new species. Thus strain JL01 (=VKM B-2370=JCM 31898) represents the first
    M. mazei isolated from permanently subzero Arcticsediments. The long-term co-cultivation
    of JL01 with S. associata GLS2T showed the methane production without any additional
    carbon and energy sources. Genome analysis of S. associata GLS2T revealed putative
    genes involved in methanochondroithin catabolism."
acknowledgement: "The work was supported by of Russian Foundation of Basic Research:
  grant № 19-04-00831 for Viktoria Shcherbakova and Olga Troshina, grant № 18-34-00334
  for Viktoriia Oshurkova and Vladimir Trubitsyn. \r\nWe thank Dr Natalia Suzina (IBPM
  RAS, Federal Research Center Pushchino Center for\r\nBiological Research RAS) for
  the help with the microscopic studies, respectively; Dr. Margarita Meyer (Division
  of Genetics, Department of Medicine, BWH and HMS, USA) and Dr Fedor Kondrashov (IST,
  Austria) for their help in obtaining the genomic sequence of strain JL01. "
article_processing_charge: Yes
author:
- first_name: Viktoriia
  full_name: Oshurkova, Viktoriia
  last_name: Oshurkova
- first_name: Olga
  full_name: Troshina, Olga
  last_name: Troshina
- first_name: Vladimir
  full_name: Trubitsyn, Vladimir
  last_name: Trubitsyn
- first_name: Yana
  full_name: Ryzhmanova, Yana
  last_name: Ryzhmanova
- first_name: Olga
  full_name: Bochkareva, Olga
  id: C4558D3C-6102-11E9-A62E-F418E6697425
  last_name: Bochkareva
  orcid: 0000-0003-1006-6639
- first_name: Viktoria
  full_name: Shcherbakova, Viktoria
  last_name: Shcherbakova
citation:
  ama: 'Oshurkova V, Troshina O, Trubitsyn V, Ryzhmanova Y, Bochkareva O, Shcherbakova
    V. Characterization of methanosarcina mazei JL01 isolated from holocene arctic
    permafrost and study of the archaeon cooperation with bacterium Sphaerochaeta
    associata GLS2T. In: <i>Proceedings of 1st International Electronic Conference
    on Microbiology</i>. MDPI; 2020. doi:<a href="https://doi.org/10.3390/ecm2020-07116">10.3390/ecm2020-07116</a>'
  apa: 'Oshurkova, V., Troshina, O., Trubitsyn, V., Ryzhmanova, Y., Bochkareva, O.,
    &#38; Shcherbakova, V. (2020). Characterization of methanosarcina mazei JL01 isolated
    from holocene arctic permafrost and study of the archaeon cooperation with bacterium
    Sphaerochaeta associata GLS2T. In <i>Proceedings of 1st International Electronic
    Conference on Microbiology</i>. Virtual: MDPI. <a href="https://doi.org/10.3390/ecm2020-07116">https://doi.org/10.3390/ecm2020-07116</a>'
  chicago: Oshurkova, Viktoriia, Olga Troshina, Vladimir Trubitsyn, Yana Ryzhmanova,
    Olga Bochkareva, and Viktoria Shcherbakova. “Characterization of Methanosarcina
    Mazei JL01 Isolated from Holocene Arctic Permafrost and Study of the Archaeon
    Cooperation with Bacterium Sphaerochaeta Associata GLS2T.” In <i>Proceedings of
    1st International Electronic Conference on Microbiology</i>. MDPI, 2020. <a href="https://doi.org/10.3390/ecm2020-07116">https://doi.org/10.3390/ecm2020-07116</a>.
  ieee: V. Oshurkova, O. Troshina, V. Trubitsyn, Y. Ryzhmanova, O. Bochkareva, and
    V. Shcherbakova, “Characterization of methanosarcina mazei JL01 isolated from
    holocene arctic permafrost and study of the archaeon cooperation with bacterium
    Sphaerochaeta associata GLS2T,” in <i>Proceedings of 1st International Electronic
    Conference on Microbiology</i>, Virtual, 2020.
  ista: 'Oshurkova V, Troshina O, Trubitsyn V, Ryzhmanova Y, Bochkareva O, Shcherbakova
    V. 2020. Characterization of methanosarcina mazei JL01 isolated from holocene
    arctic permafrost and study of the archaeon cooperation with bacterium Sphaerochaeta
    associata GLS2T. Proceedings of 1st International Electronic Conference on Microbiology.
    ECM: Electronic Conference on Microbiology.'
  mla: Oshurkova, Viktoriia, et al. “Characterization of Methanosarcina Mazei JL01
    Isolated from Holocene Arctic Permafrost and Study of the Archaeon Cooperation
    with Bacterium Sphaerochaeta Associata GLS2T.” <i>Proceedings of 1st International
    Electronic Conference on Microbiology</i>, MDPI, 2020, doi:<a href="https://doi.org/10.3390/ecm2020-07116">10.3390/ecm2020-07116</a>.
  short: V. Oshurkova, O. Troshina, V. Trubitsyn, Y. Ryzhmanova, O. Bochkareva, V.
    Shcherbakova, in:, Proceedings of 1st International Electronic Conference on Microbiology,
    MDPI, 2020.
conference:
  end_date: 2020-11-30
  location: Virtual
  name: 'ECM: Electronic Conference on Microbiology'
  start_date: 2020-11-02
date_created: 2024-03-04T11:41:31Z
date_published: 2020-11-02T00:00:00Z
date_updated: 2024-03-20T08:06:22Z
day: '02'
ddc:
- '570'
department:
- _id: FyKo
doi: 10.3390/ecm2020-07116
file:
- access_level: open_access
  checksum: d1914af7811a21a4b2744eb51b5834e3
  content_type: application/pdf
  creator: dernst
  date_created: 2024-03-20T08:05:46Z
  date_updated: 2024-03-20T08:05:46Z
  file_id: '15127'
  file_name: 2020_ECM_Oshurkova.pdf
  file_size: 595543
  relation: main_file
  success: 1
file_date_updated: 2024-03-20T08:05:46Z
has_accepted_license: '1'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: Proceedings of 1st International Electronic Conference on Microbiology
publication_status: published
publisher: MDPI
quality_controlled: '1'
status: public
title: Characterization of methanosarcina mazei JL01 isolated from holocene arctic
  permafrost and study of the archaeon cooperation with bacterium Sphaerochaeta associata
  GLS2T
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '15077'
abstract:
- lang: eng
  text: "We consider the following dynamic load-balancing process: given an underlying
    graph G with n nodes, in each step t≥ 0, one unit of load is created, and placed
    at a randomly chosen graph node. In the same step, the chosen node picks a random
    neighbor, and the two nodes balance their loads by averaging them. We are interested
    in the expected gap between the minimum and maximum loads at nodes as the process
    progresses, and its dependence on n and on the graph structure. Variants of the
    above graphical balanced allocation process have been studied previously by Peres,
    Talwar, and Wieder [Peres et al., 2015], and by Sauerwald and Sun [Sauerwald and
    Sun, 2015]. These authors left as open the question of characterizing the gap
    in the case of cycle graphs in the dynamic case, where weights are created during
    the algorithm’s execution. For this case, the only known upper bound is of \U0001D4AA(n
    log n), following from a majorization argument due to [Peres et al., 2015], which
    analyzes a related graphical allocation process. In this paper, we provide an
    upper bound of \U0001D4AA (√n log n) on the expected gap of the above process
    for cycles of length n. We introduce a new potential analysis technique, which
    enables us to bound the difference in load between k-hop neighbors on the cycle,
    for any k ≤ n/2. We complement this with a \"gap covering\" argument, which bounds
    the maximum value of the gap by bounding its value across all possible subsets
    of a certain structure, and recursively bounding the gaps within each subset.
    We provide analytical and experimental evidence that our upper bound on the gap
    is tight up to a logarithmic factor."
acknowledgement: "The authors sincerely thank Thomas Sauerwald and George Giakkoupis
  for insightful discussions, and Mohsen Ghaffari, Yuval Peres, and Udi Wieder for
  feedback on earlier\r\nversions of this draft. We also thank the ICALP anonymous
  reviewers for their very useful comments.\r\nFunding: European Research Council
  funding award PR1042ERC01"
alternative_title:
- LIPIcs
article_number: '7'
article_processing_charge: No
arxiv: 1
author:
- first_name: Dan-Adrian
  full_name: Alistarh, Dan-Adrian
  id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
  last_name: Alistarh
  orcid: 0000-0003-3650-940X
- first_name: Giorgi
  full_name: Nadiradze, Giorgi
  id: 3279A00C-F248-11E8-B48F-1D18A9856A87
  last_name: Nadiradze
  orcid: 0000-0001-5634-0731
- first_name: Amirmojtaba
  full_name: Sabour, Amirmojtaba
  id: bcc145fd-e77f-11ea-ae8b-80d661dbff67
  last_name: Sabour
citation:
  ama: 'Alistarh D-A, Nadiradze G, Sabour A. Dynamic averaging load balancing on cycles.
    In: <i>47th International Colloquium on Automata, Languages, and Programming</i>.
    Vol 168. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2020. doi:<a href="https://doi.org/10.4230/LIPIcs.ICALP.2020.7">10.4230/LIPIcs.ICALP.2020.7</a>'
  apa: 'Alistarh, D.-A., Nadiradze, G., &#38; Sabour, A. (2020). Dynamic averaging
    load balancing on cycles. In <i>47th International Colloquium on Automata, Languages,
    and Programming</i> (Vol. 168). Saarbrücken, Germany, Virtual: Schloss Dagstuhl
    - Leibniz-Zentrum für Informatik. <a href="https://doi.org/10.4230/LIPIcs.ICALP.2020.7">https://doi.org/10.4230/LIPIcs.ICALP.2020.7</a>'
  chicago: Alistarh, Dan-Adrian, Giorgi Nadiradze, and Amirmojtaba Sabour. “Dynamic
    Averaging Load Balancing on Cycles.” In <i>47th International Colloquium on Automata,
    Languages, and Programming</i>, Vol. 168. Schloss Dagstuhl - Leibniz-Zentrum für
    Informatik, 2020. <a href="https://doi.org/10.4230/LIPIcs.ICALP.2020.7">https://doi.org/10.4230/LIPIcs.ICALP.2020.7</a>.
  ieee: D.-A. Alistarh, G. Nadiradze, and A. Sabour, “Dynamic averaging load balancing
    on cycles,” in <i>47th International Colloquium on Automata, Languages, and Programming</i>,
    Saarbrücken, Germany, Virtual, 2020, vol. 168.
  ista: 'Alistarh D-A, Nadiradze G, Sabour A. 2020. Dynamic averaging load balancing
    on cycles. 47th International Colloquium on Automata, Languages, and Programming.
    ICALP: Automata, Languages and Programming, LIPIcs, vol. 168, 7.'
  mla: Alistarh, Dan-Adrian, et al. “Dynamic Averaging Load Balancing on Cycles.”
    <i>47th International Colloquium on Automata, Languages, and Programming</i>,
    vol. 168, 7, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020, doi:<a href="https://doi.org/10.4230/LIPIcs.ICALP.2020.7">10.4230/LIPIcs.ICALP.2020.7</a>.
  short: D.-A. Alistarh, G. Nadiradze, A. Sabour, in:, 47th International Colloquium
    on Automata, Languages, and Programming, Schloss Dagstuhl - Leibniz-Zentrum für
    Informatik, 2020.
conference:
  end_date: 2020-07-11
  location: Saarbrücken, Germany, Virtual
  name: 'ICALP: Automata, Languages and Programming'
  start_date: 2020-07-08
corr_author: '1'
date_created: 2024-03-05T07:25:37Z
date_published: 2020-06-29T00:00:00Z
date_updated: 2025-07-10T11:55:11Z
day: '29'
ddc:
- '000'
department:
- _id: DaAl
doi: 10.4230/LIPIcs.ICALP.2020.7
ec_funded: 1
external_id:
  arxiv:
  - '2003.09297'
file:
- access_level: open_access
  checksum: e5eb16199f4ccfd77a321977eb3f026f
  content_type: application/pdf
  creator: dernst
  date_created: 2024-03-05T07:25:15Z
  date_updated: 2024-03-05T07:25:15Z
  file_id: '15078'
  file_name: 2020_LIPIcs_Alistarh.pdf
  file_size: 782987
  relation: main_file
  success: 1
file_date_updated: 2024-03-05T07:25:15Z
has_accepted_license: '1'
intvolume: '       168'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/3.0/
month: '06'
oa: 1
oa_version: Published Version
project:
- _id: 268A44D6-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '805223'
  name: Elastic Coordination for Scalable Machine Learning
publication: 47th International Colloquium on Automata, Languages, and Programming
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
related_material:
  record:
  - id: '8286'
    relation: later_version
    status: public
scopus_import: '1'
status: public
title: Dynamic averaging load balancing on cycles
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/3.0/legalcode
  name: Creative Commons Attribution 3.0 Unported (CC BY 3.0)
  short: CC BY (3.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 168
year: '2020'
...
---
_id: '15082'
abstract:
- lang: eng
  text: "Two plane drawings of geometric graphs on the same set of points are called
    disjoint compatible if their union is plane and they do not have an edge in common.
    For a given set S of 2n points two plane drawings of perfect matchings M1 and
    M2 (which do not need to be disjoint nor compatible) are disjoint tree-compatible
    if there exists a plane drawing of a spanning tree T on S which is disjoint compatible
    to both M1 and M2.\r\nWe show that the graph of all disjoint tree-compatible perfect
    geometric matchings on 2n points in convex position is connected if and only if
    2n ≥ 10. Moreover, in that case the diameter\r\nof this graph is either 4 or 5,
    independent of n."
acknowledgement: Research on this work was initiated at the 6th Austrian-Japanese-Mexican-Spanish
  Workshop on Discrete Geometry and continued during the 16th European Geometric Graph-Week,
  both held near Strobl, Austria. We are grateful to the participants for the inspiring
  atmosphere. We especially thank Alexander Pilz for bringing this class of problems
  to our attention and Birgit Vogtenhuber for inspiring discussions. D.P. is partially
  supported by the FWF grant I 3340-N35 (Collaborative DACH project Arrangements and
  Drawings). The research stay of P.P. at IST Austria is funded by the project CZ.02.2.69/0.0/0.0/17_050/0008466
  Improvement of internationalization in the field of research and development at
  Charles University, through the support of quality projects MSCA-IF. This project
  has received funding from the European Union’s Horizon 2020 research and innovation
  programme under the Marie Skłodowska-Curie grant agreement No 734922.
article_number: '56'
article_processing_charge: No
author:
- first_name: Oswin
  full_name: Aichholzer, Oswin
  last_name: Aichholzer
- first_name: Julia
  full_name: Obmann, Julia
  last_name: Obmann
- first_name: Pavel
  full_name: Patak, Pavel
  id: B593B804-1035-11EA-B4F1-947645A5BB83
  last_name: Patak
- first_name: Daniel
  full_name: Perz, Daniel
  last_name: Perz
- first_name: Josef
  full_name: Tkadlec, Josef
  id: 3F24CCC8-F248-11E8-B48F-1D18A9856A87
  last_name: Tkadlec
  orcid: 0000-0002-1097-9684
citation:
  ama: 'Aichholzer O, Obmann J, Patak P, Perz D, Tkadlec J. Disjoint tree-compatible
    plane perfect matchings. In: <i>36th European Workshop on Computational Geometry</i>.
    ; 2020.'
  apa: Aichholzer, O., Obmann, J., Patak, P., Perz, D., &#38; Tkadlec, J. (2020).
    Disjoint tree-compatible plane perfect matchings. In <i>36th European Workshop
    on Computational Geometry</i>. Würzburg, Germany, Virtual.
  chicago: Aichholzer, Oswin, Julia Obmann, Pavel Patak, Daniel Perz, and Josef Tkadlec.
    “Disjoint Tree-Compatible Plane Perfect Matchings.” In <i>36th European Workshop
    on Computational Geometry</i>, 2020.
  ieee: O. Aichholzer, J. Obmann, P. Patak, D. Perz, and J. Tkadlec, “Disjoint tree-compatible
    plane perfect matchings,” in <i>36th European Workshop on Computational Geometry</i>,
    Würzburg, Germany, Virtual, 2020.
  ista: 'Aichholzer O, Obmann J, Patak P, Perz D, Tkadlec J. 2020. Disjoint tree-compatible
    plane perfect matchings. 36th European Workshop on Computational Geometry. EuroCG:
    European Workshop on Computational Geometry, 56.'
  mla: Aichholzer, Oswin, et al. “Disjoint Tree-Compatible Plane Perfect Matchings.”
    <i>36th European Workshop on Computational Geometry</i>, 56, 2020.
  short: O. Aichholzer, J. Obmann, P. Patak, D. Perz, J. Tkadlec, in:, 36th European
    Workshop on Computational Geometry, 2020.
conference:
  end_date: 2020-03-18
  location: Würzburg, Germany, Virtual
  name: 'EuroCG: European Workshop on Computational Geometry'
  start_date: 2020-03-16
corr_author: '1'
date_created: 2024-03-05T08:57:17Z
date_published: 2020-04-01T00:00:00Z
date_updated: 2026-06-18T17:45:52Z
day: '01'
ddc:
- '000'
department:
- _id: KrCh
- _id: UlWa
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www1.pub.informatik.uni-wuerzburg.de/eurocg2020/data/uploads/papers/eurocg20_paper_56.pdf
month: '04'
oa: 1
oa_version: Published Version
publication: 36th European Workshop on Computational Geometry
publication_status: published
quality_controlled: '1'
status: public
title: Disjoint tree-compatible plane perfect matchings
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '15086'
abstract:
- lang: eng
  text: "Many communication-efficient variants of SGD use gradient quantization schemes.
    These schemes are often heuristic and fixed over the course of training. We empirically
    observe that the statistics of gradients of deep models change during the training.
    Motivated by this observation, we introduce two adaptive quantization schemes,
    ALQ and AMQ. In both schemes, processors update their compression schemes in parallel
    by efficiently computing sufficient statistics of a parametric distribution. We
    improve the validation accuracy by almost 2% on CIFAR-10 and 1% on ImageNet in
    challenging low-cost communication setups. Our adaptive methods are also significantly
    more robust to the choice of hyperparameters.\r\n\r\n"
acknowledgement: "The authors would like to thank Blair Bilodeau, David Fleet, Mufan
  Li, and Jeffrey Negrea for\r\nhelpful discussions. FF was supported by OGS Scholarship.
  DA and IM were supported the\r\nEuropean Research Council (ERC) under the European
  Union’s Horizon 2020 research and innovation\r\nprogramme (grant agreement No 805223
  ScaleML). DMR was supported by an NSERC Discovery\r\nGrant. ARK was supported by
  NSERC Postdoctoral Fellowship. Resources used in preparing this research were provided,
  in part, by the Province of Ontario, the Government of Canada through CIFAR, and
  companies sponsoring the Vector Institute."
alternative_title:
- NeurIPS
article_processing_charge: No
arxiv: 1
author:
- first_name: 'Fartash '
  full_name: 'Faghri, Fartash '
  last_name: Faghri
- first_name: 'Iman '
  full_name: 'Tabrizian, Iman '
  last_name: Tabrizian
- first_name: Ilia
  full_name: Markov, Ilia
  id: D0CF4148-C985-11E9-8066-0BDEE5697425
  last_name: Markov
- first_name: Dan-Adrian
  full_name: Alistarh, Dan-Adrian
  id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
  last_name: Alistarh
  orcid: 0000-0003-3650-940X
- first_name: 'Daniel '
  full_name: 'Roy, Daniel '
  last_name: Roy
- first_name: 'Ali '
  full_name: 'Ramezani-Kebrya, Ali '
  last_name: Ramezani-Kebrya
citation:
  ama: 'Faghri F, Tabrizian I, Markov I, Alistarh D-A, Roy D, Ramezani-Kebrya A. Adaptive
    gradient quantization for data-parallel SGD. In: <i>Advances in Neural Information
    Processing Systems</i>. Vol 33. Neural Information Processing Systems Foundation;
    2020.'
  apa: 'Faghri, F., Tabrizian, I., Markov, I., Alistarh, D.-A., Roy, D., &#38; Ramezani-Kebrya,
    A. (2020). Adaptive gradient quantization for data-parallel SGD. In <i>Advances
    in Neural Information Processing Systems</i> (Vol. 33). Vancouver, Canada: Neural
    Information Processing Systems Foundation.'
  chicago: Faghri, Fartash , Iman  Tabrizian, Ilia Markov, Dan-Adrian Alistarh, Daniel  Roy,
    and Ali  Ramezani-Kebrya. “Adaptive Gradient Quantization for Data-Parallel SGD.”
    In <i>Advances in Neural Information Processing Systems</i>, Vol. 33. Neural Information
    Processing Systems Foundation, 2020.
  ieee: F. Faghri, I. Tabrizian, I. Markov, D.-A. Alistarh, D. Roy, and A. Ramezani-Kebrya,
    “Adaptive gradient quantization for data-parallel SGD,” in <i>Advances in Neural
    Information Processing Systems</i>, Vancouver, Canada, 2020, vol. 33.
  ista: 'Faghri F, Tabrizian I, Markov I, Alistarh D-A, Roy D, Ramezani-Kebrya A.
    2020. Adaptive gradient quantization for data-parallel SGD. Advances in Neural
    Information Processing Systems. NeurIPS: Neural Information Processing Systems,
    NeurIPS, vol. 33.'
  mla: Faghri, Fartash, et al. “Adaptive Gradient Quantization for Data-Parallel SGD.”
    <i>Advances in Neural Information Processing Systems</i>, vol. 33, Neural Information
    Processing Systems Foundation, 2020.
  short: F. Faghri, I. Tabrizian, I. Markov, D.-A. Alistarh, D. Roy, A. Ramezani-Kebrya,
    in:, Advances in Neural Information Processing Systems, Neural Information Processing
    Systems Foundation, 2020.
conference:
  end_date: 2020-12-12
  location: Vancouver, Canada
  name: 'NeurIPS: Neural Information Processing Systems'
  start_date: 2020-12-06
date_created: 2024-03-06T08:35:58Z
date_published: 2020-12-10T00:00:00Z
date_updated: 2025-04-14T07:49:16Z
day: '10'
department:
- _id: DaAl
ec_funded: 1
external_id:
  arxiv:
  - '2010.12460'
intvolume: '        33'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2010.12460
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: 268A44D6-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '805223'
  name: Elastic Coordination for Scalable Machine Learning
publication: Advances in Neural Information Processing Systems
publication_identifier:
  isbn:
  - '9781713829546'
publication_status: published
publisher: Neural Information Processing Systems Foundation
quality_controlled: '1'
status: public
title: Adaptive gradient quantization for data-parallel SGD
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '2020'
...
---
_id: '15142'
abstract:
- lang: eng
  text: Bacteria and archaea employ CRISPR (clustered, regularly, interspaced, short
    palindromic repeats)-Cas (CRISPR-associated) systems as a type of adaptive immunity
    to target and degrade foreign nucleic acids. While a myriad of CRISPR-Cas systems
    have been identified to date, type I-C is one of the most commonly found subtypes
    in nature. Interestingly, the type I-C system employs a minimal Cascade effector
    complex, which encodes only three unique subunits in its operon. Here, we present
    a 3.1 Å resolution cryo-EM structure of the <jats:italic>Desulfovibrio vulgaris</jats:italic>
    type I-C Cascade, revealing the molecular mechanisms that underlie RNA-directed
    complex assembly. We demonstrate how this minimal Cascade utilizes previously
    overlooked, non-canonical small subunits to stabilize R-loop formation. Furthermore,
    we describe putative PAM and Cas3 binding sites. These findings provide the structural
    basis for harnessing the type I-C Cascade as a genome-engineering tool.
article_number: '5931'
article_processing_charge: Yes
article_type: original
author:
- first_name: Roisin E.
  full_name: O’Brien, Roisin E.
  last_name: O’Brien
- first_name: Inês C.
  full_name: Santos, Inês C.
  last_name: Santos
- first_name: Daniel
  full_name: Wrapp, Daniel
  last_name: Wrapp
- first_name: Jack Peter Kelly
  full_name: Bravo, Jack Peter Kelly
  id: 96aecfa5-8931-11ee-af30-aa6a5d6eee0e
  last_name: Bravo
  orcid: 0000-0003-0456-0753
- first_name: Evan A.
  full_name: Schwartz, Evan A.
  last_name: Schwartz
- first_name: Jennifer S.
  full_name: Brodbelt, Jennifer S.
  last_name: Brodbelt
- first_name: David W.
  full_name: Taylor, David W.
  last_name: Taylor
citation:
  ama: O’Brien RE, Santos IC, Wrapp D, et al. Structural basis for assembly of non-canonical
    small subunits into type I-C Cascade. <i>Nature Communications</i>. 2020;11. doi:<a
    href="https://doi.org/10.1038/s41467-020-19785-8">10.1038/s41467-020-19785-8</a>
  apa: O’Brien, R. E., Santos, I. C., Wrapp, D., Bravo, J. P. K., Schwartz, E. A.,
    Brodbelt, J. S., &#38; Taylor, D. W. (2020). Structural basis for assembly of
    non-canonical small subunits into type I-C Cascade. <i>Nature Communications</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41467-020-19785-8">https://doi.org/10.1038/s41467-020-19785-8</a>
  chicago: O’Brien, Roisin E., Inês C. Santos, Daniel Wrapp, Jack Peter Kelly Bravo,
    Evan A. Schwartz, Jennifer S. Brodbelt, and David W. Taylor. “Structural Basis
    for Assembly of Non-Canonical Small Subunits into Type I-C Cascade.” <i>Nature
    Communications</i>. Springer Nature, 2020. <a href="https://doi.org/10.1038/s41467-020-19785-8">https://doi.org/10.1038/s41467-020-19785-8</a>.
  ieee: R. E. O’Brien <i>et al.</i>, “Structural basis for assembly of non-canonical
    small subunits into type I-C Cascade,” <i>Nature Communications</i>, vol. 11.
    Springer Nature, 2020.
  ista: O’Brien RE, Santos IC, Wrapp D, Bravo JPK, Schwartz EA, Brodbelt JS, Taylor
    DW. 2020. Structural basis for assembly of non-canonical small subunits into type
    I-C Cascade. Nature Communications. 11, 5931.
  mla: O’Brien, Roisin E., et al. “Structural Basis for Assembly of Non-Canonical
    Small Subunits into Type I-C Cascade.” <i>Nature Communications</i>, vol. 11,
    5931, Springer Nature, 2020, doi:<a href="https://doi.org/10.1038/s41467-020-19785-8">10.1038/s41467-020-19785-8</a>.
  short: R.E. O’Brien, I.C. Santos, D. Wrapp, J.P.K. Bravo, E.A. Schwartz, J.S. Brodbelt,
    D.W. Taylor, Nature Communications 11 (2020).
date_created: 2024-03-20T10:43:07Z
date_published: 2020-11-23T00:00:00Z
date_updated: 2024-06-04T05:52:51Z
day: '23'
doi: 10.1038/s41467-020-19785-8
extern: '1'
external_id:
  pmid:
  - '33230133'
intvolume: '        11'
keyword:
- General Physics and Astronomy
- General Biochemistry
- Genetics and Molecular Biology
- General Chemistry
- Multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1038/s41467-020-19785-8
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
  issn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Structural basis for assembly of non-canonical small subunits into type I-C
  Cascade
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2020'
...
---
_id: '15152'
abstract:
- lang: eng
  text: Transcription factors (TFs) regulate gene expression through chromatin where
    nucleosomes restrict DNA access. To study how TFs bind nucleosome-occupied motifs,
    we focused on the reprogramming factors OCT4 and SOX2 in mouse embryonic stem
    cells. We determined TF engagement throughout a nucleosome at base-pair resolution
    in vitro, enabling structure determination by cryo–electron microscopy at two
    preferred positions. Depending on motif location, OCT4 and SOX2 differentially
    distort nucleosomal DNA. At one position, OCT4-SOX2 removes DNA from histone H2A
    and histone H3; however, at an inverted motif, the TFs only induce local DNA distortions.
    OCT4 uses one of its two DNA-binding domains to engage DNA in both structures,
    reading out a partial motif. These findings explain site-specific nucleosome engagement
    by the pluripotency factors OCT4 and SOX2, and they reveal how TFs distort nucleosomes
    to access chromatinized motifs.
article_processing_charge: No
article_type: original
author:
- first_name: Alicia Kathleen
  full_name: Michael, Alicia Kathleen
  id: 6437c950-2a03-11ee-914d-d6476dd7b75c
  last_name: Michael
  orcid: 0000-0002-6080-839X
- first_name: Ralph S.
  full_name: Grand, Ralph S.
  last_name: Grand
- first_name: Luke
  full_name: Isbel, Luke
  last_name: Isbel
- first_name: Simone
  full_name: Cavadini, Simone
  last_name: Cavadini
- first_name: Zuzanna
  full_name: Kozicka, Zuzanna
  last_name: Kozicka
- first_name: Georg
  full_name: Kempf, Georg
  last_name: Kempf
- first_name: Richard D.
  full_name: Bunker, Richard D.
  last_name: Bunker
- first_name: Andreas D.
  full_name: Schenk, Andreas D.
  last_name: Schenk
- first_name: Alexandra
  full_name: Graff-Meyer, Alexandra
  last_name: Graff-Meyer
- first_name: Ganesh R.
  full_name: Pathare, Ganesh R.
  last_name: Pathare
- first_name: Joscha
  full_name: Weiss, Joscha
  last_name: Weiss
- first_name: Syota
  full_name: Matsumoto, Syota
  last_name: Matsumoto
- first_name: Lukas
  full_name: Burger, Lukas
  last_name: Burger
- first_name: Dirk
  full_name: Schübeler, Dirk
  last_name: Schübeler
- first_name: Nicolas H.
  full_name: Thomä, Nicolas H.
  last_name: Thomä
citation:
  ama: Michael AK, Grand RS, Isbel L, et al. Mechanisms of OCT4-SOX2 motif readout
    on nucleosomes. <i>Science</i>. 2020;368(6498):1460-1465. doi:<a href="https://doi.org/10.1126/science.abb0074">10.1126/science.abb0074</a>
  apa: Michael, A. K., Grand, R. S., Isbel, L., Cavadini, S., Kozicka, Z., Kempf,
    G., … Thomä, N. H. (2020). Mechanisms of OCT4-SOX2 motif readout on nucleosomes.
    <i>Science</i>. American Association for the Advancement of Science . <a href="https://doi.org/10.1126/science.abb0074">https://doi.org/10.1126/science.abb0074</a>
  chicago: Michael, Alicia K., Ralph S. Grand, Luke Isbel, Simone Cavadini, Zuzanna
    Kozicka, Georg Kempf, Richard D. Bunker, et al. “Mechanisms of OCT4-SOX2 Motif
    Readout on Nucleosomes.” <i>Science</i>. American Association for the Advancement
    of Science , 2020. <a href="https://doi.org/10.1126/science.abb0074">https://doi.org/10.1126/science.abb0074</a>.
  ieee: A. K. Michael <i>et al.</i>, “Mechanisms of OCT4-SOX2 motif readout on nucleosomes,”
    <i>Science</i>, vol. 368, no. 6498. American Association for the Advancement of
    Science , pp. 1460–1465, 2020.
  ista: Michael AK, Grand RS, Isbel L, Cavadini S, Kozicka Z, Kempf G, Bunker RD,
    Schenk AD, Graff-Meyer A, Pathare GR, Weiss J, Matsumoto S, Burger L, Schübeler
    D, Thomä NH. 2020. Mechanisms of OCT4-SOX2 motif readout on nucleosomes. Science.
    368(6498), 1460–1465.
  mla: Michael, Alicia K., et al. “Mechanisms of OCT4-SOX2 Motif Readout on Nucleosomes.”
    <i>Science</i>, vol. 368, no. 6498, American Association for the Advancement of
    Science , 2020, pp. 1460–65, doi:<a href="https://doi.org/10.1126/science.abb0074">10.1126/science.abb0074</a>.
  short: A.K. Michael, R.S. Grand, L. Isbel, S. Cavadini, Z. Kozicka, G. Kempf, R.D.
    Bunker, A.D. Schenk, A. Graff-Meyer, G.R. Pathare, J. Weiss, S. Matsumoto, L.
    Burger, D. Schübeler, N.H. Thomä, Science 368 (2020) 1460–1465.
date_created: 2024-03-21T07:54:44Z
date_published: 2020-04-23T00:00:00Z
date_updated: 2024-03-25T12:29:34Z
day: '23'
doi: 10.1126/science.abb0074
extern: '1'
intvolume: '       368'
issue: '6498'
language:
- iso: eng
month: '04'
oa_version: None
page: 1460-1465
publication: Science
publication_identifier:
  eissn:
  - 1095-9203
  issn:
  - 0036-8075
publication_status: published
publisher: 'American Association for the Advancement of Science '
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanisms of OCT4-SOX2 motif readout on nucleosomes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 368
year: '2020'
...
---
_id: '15153'
abstract:
- lang: eng
  text: Mammalian circadian rhythms are generated by a transcription-based feedback
    loop in which CLOCK:BMAL1 drives transcription of its repressors (PER1/2, CRY1/2),
    which ultimately interact with CLOCK:BMAL1 to close the feedback loop with ~24
    hr periodicity. Here we pinpoint a key difference between CRY1 and CRY2 that underlies
    their differential strengths as transcriptional repressors. Both cryptochromes
    bind the BMAL1 transactivation domain similarly to sequester it from coactivators
    and repress CLOCK:BMAL1 activity. However, we find that CRY1 is recruited with
    much higher affinity to the PAS domain core of CLOCK:BMAL1, allowing it to serve
    as a stronger repressor that lengthens circadian period. We discovered a dynamic
    serine-rich loop adjacent to the secondary pocket in the photolyase homology region
    (PHR) domain that regulates differential binding of cryptochromes to the PAS domain
    core of CLOCK:BMAL1. Notably, binding of the co-repressor PER2 remodels the serine
    loop of CRY2, making it more CRY1-like and enhancing its affinity for CLOCK:BMAL1.
article_number: '55275'
article_processing_charge: No
article_type: original
author:
- first_name: Jennifer L
  full_name: Fribourgh, Jennifer L
  last_name: Fribourgh
- first_name: Ashutosh
  full_name: Srivastava, Ashutosh
  last_name: Srivastava
- first_name: Colby R
  full_name: Sandate, Colby R
  last_name: Sandate
- first_name: Alicia Kathleen
  full_name: Michael, Alicia Kathleen
  id: 6437c950-2a03-11ee-914d-d6476dd7b75c
  last_name: Michael
- first_name: Peter L
  full_name: Hsu, Peter L
  last_name: Hsu
- first_name: Christin
  full_name: Rakers, Christin
  last_name: Rakers
- first_name: Leslee T
  full_name: Nguyen, Leslee T
  last_name: Nguyen
- first_name: Megan R
  full_name: Torgrimson, Megan R
  last_name: Torgrimson
- first_name: Gian Carlo G
  full_name: Parico, Gian Carlo G
  last_name: Parico
- first_name: Sarvind
  full_name: Tripathi, Sarvind
  last_name: Tripathi
- first_name: Ning
  full_name: Zheng, Ning
  last_name: Zheng
- first_name: Gabriel C
  full_name: Lander, Gabriel C
  last_name: Lander
- first_name: Tsuyoshi
  full_name: Hirota, Tsuyoshi
  last_name: Hirota
- first_name: Florence
  full_name: Tama, Florence
  last_name: Tama
- first_name: Carrie L
  full_name: Partch, Carrie L
  last_name: Partch
citation:
  ama: Fribourgh JL, Srivastava A, Sandate CR, et al. Dynamics at the serine loop
    underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian
    timing. <i>eLife</i>. 2020;9. doi:<a href="https://doi.org/10.7554/elife.55275">10.7554/elife.55275</a>
  apa: Fribourgh, J. L., Srivastava, A., Sandate, C. R., Michael, A. K., Hsu, P. L.,
    Rakers, C., … Partch, C. L. (2020). Dynamics at the serine loop underlie differential
    affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing. <i>ELife</i>.
    eLife Sciences Publications. <a href="https://doi.org/10.7554/elife.55275">https://doi.org/10.7554/elife.55275</a>
  chicago: Fribourgh, Jennifer L, Ashutosh Srivastava, Colby R Sandate, Alicia K.
    Michael, Peter L Hsu, Christin Rakers, Leslee T Nguyen, et al. “Dynamics at the
    Serine Loop Underlie Differential Affinity of Cryptochromes for CLOCK:BMAL1 to
    Control Circadian Timing.” <i>ELife</i>. eLife Sciences Publications, 2020. <a
    href="https://doi.org/10.7554/elife.55275">https://doi.org/10.7554/elife.55275</a>.
  ieee: J. L. Fribourgh <i>et al.</i>, “Dynamics at the serine loop underlie differential
    affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing,” <i>eLife</i>,
    vol. 9. eLife Sciences Publications, 2020.
  ista: Fribourgh JL, Srivastava A, Sandate CR, Michael AK, Hsu PL, Rakers C, Nguyen
    LT, Torgrimson MR, Parico GCG, Tripathi S, Zheng N, Lander GC, Hirota T, Tama
    F, Partch CL. 2020. Dynamics at the serine loop underlie differential affinity
    of cryptochromes for CLOCK:BMAL1 to control circadian timing. eLife. 9, 55275.
  mla: Fribourgh, Jennifer L., et al. “Dynamics at the Serine Loop Underlie Differential
    Affinity of Cryptochromes for CLOCK:BMAL1 to Control Circadian Timing.” <i>ELife</i>,
    vol. 9, 55275, eLife Sciences Publications, 2020, doi:<a href="https://doi.org/10.7554/elife.55275">10.7554/elife.55275</a>.
  short: J.L. Fribourgh, A. Srivastava, C.R. Sandate, A.K. Michael, P.L. Hsu, C. Rakers,
    L.T. Nguyen, M.R. Torgrimson, G.C.G. Parico, S. Tripathi, N. Zheng, G.C. Lander,
    T. Hirota, F. Tama, C.L. Partch, ELife 9 (2020).
date_created: 2024-03-21T07:55:12Z
date_published: 2020-02-26T00:00:00Z
date_updated: 2024-03-25T12:25:02Z
day: '26'
doi: 10.7554/elife.55275
extern: '1'
intvolume: '         9'
keyword:
- General Immunology and Microbiology
- General Biochemistry
- Genetics and Molecular Biology
- General Medicine
- General Neuroscience
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.7554/eLife.55275
month: '02'
oa: 1
oa_version: Published Version
publication: eLife
publication_identifier:
  issn:
  - 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dynamics at the serine loop underlie differential affinity of cryptochromes
  for CLOCK:BMAL1 to control circadian timing
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2020'
...
---
_id: '15220'
abstract:
- lang: eng
  text: 'A new window is opening in high-energy astronomy: X-ray polarimetry. With
    many missions currently under development and scheduled to launch as early as
    2021, observations of the X-ray polarization of accreting X-ray pulsars will soon
    be available. As polarization is particularly sensitive to the geometry of the
    emission region, the upcoming polarimeters will shed new light on the emission
    mechanism of these objects, provided that we have sound theoretical models that
    agree with current spectroscopic and timing observation and that can make predictions
    of the polarization parameters of the emission. We here present a new model for
    the polarized emission of accreting X-ray pulsars in the accretion column scenario
    that for the first time takes into account the macroscopic structure and dynamics
    of the accretion region and the propagation of the radiation towards the observer,
    including relativistic beaming, gravitational lensing, and quantum electrodynamics.
    In this paper, we present all the details of the model, while in a companion paper,
    we apply our model to predict the polarization parameters of the bright X-ray
    pulsar Hercules X-1.'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Ilaria
  full_name: Caiazzo, Ilaria
  id: 8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d
  last_name: Caiazzo
  orcid: 0000-0002-4770-5388
- first_name: Jeremy
  full_name: Heyl, Jeremy
  last_name: Heyl
citation:
  ama: Caiazzo I, Heyl J. Polarization of accreting X-ray pulsars. I. A new model.
    <i>Monthly Notices of the Royal Astronomical Society</i>. 2020;501(1):109-128.
    doi:<a href="https://doi.org/10.1093/mnras/staa3428">10.1093/mnras/staa3428</a>
  apa: Caiazzo, I., &#38; Heyl, J. (2020). Polarization of accreting X-ray pulsars.
    I. A new model. <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford
    University Press. <a href="https://doi.org/10.1093/mnras/staa3428">https://doi.org/10.1093/mnras/staa3428</a>
  chicago: Caiazzo, Ilaria, and Jeremy Heyl. “Polarization of Accreting X-Ray Pulsars.
    I. A New Model.” <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford
    University Press, 2020. <a href="https://doi.org/10.1093/mnras/staa3428">https://doi.org/10.1093/mnras/staa3428</a>.
  ieee: I. Caiazzo and J. Heyl, “Polarization of accreting X-ray pulsars. I. A new
    model,” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 501, no.
    1. Oxford University Press, pp. 109–128, 2020.
  ista: Caiazzo I, Heyl J. 2020. Polarization of accreting X-ray pulsars. I. A new
    model. Monthly Notices of the Royal Astronomical Society. 501(1), 109–128.
  mla: Caiazzo, Ilaria, and Jeremy Heyl. “Polarization of Accreting X-Ray Pulsars.
    I. A New Model.” <i>Monthly Notices of the Royal Astronomical Society</i>, vol.
    501, no. 1, Oxford University Press, 2020, pp. 109–28, doi:<a href="https://doi.org/10.1093/mnras/staa3428">10.1093/mnras/staa3428</a>.
  short: I. Caiazzo, J. Heyl, Monthly Notices of the Royal Astronomical Society 501
    (2020) 109–128.
date_created: 2024-03-26T10:33:43Z
date_published: 2020-11-05T00:00:00Z
date_updated: 2024-10-14T12:32:49Z
day: '05'
doi: 10.1093/mnras/staa3428
extern: '1'
external_id:
  arxiv:
  - '2009.00631'
intvolume: '       501'
issue: '1'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2009.00631
month: '11'
oa: 1
oa_version: Preprint
page: 109-128
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
  eissn:
  - 1365-2966
  issn:
  - 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Polarization of accreting X-ray pulsars. I. A new model
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 501
year: '2020'
...
---
_id: '15221'
abstract:
- lang: eng
  text: We employ our new model for the polarized emission of accreting X-ray pulsars
    to describe the emission from the luminous X-ray pulsar Hercules X-1. In contrast
    with previous works, our model predicts the polarization parameters independently
    of spectral formation, and considers the structure and dynamics of the accretion
    column, as well as the additional effects on propagation due to general relativity
    and quantum electrodynamics. We find that our model can describe the observed
    pulse fraction and the pulse shape of the main peak, as well as the modulation
    of the cyclotron line with phase. We pick two geometries, assuming a single accretion
    column or two columns at the magnetic poles, that can describe current observations
    of pulse shape and cyclotron modulation with phase. Both models predict a high
    polarization fraction, between 60 and 80 per cent in the 1–10 keV range, that
    is phase and energy dependent, and that peaks at the same phase as the intensity.
    The phase and energy dependence of the polarization fraction and of the polarization
    angle can help discern between the different geometries.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Ilaria
  full_name: Caiazzo, Ilaria
  id: 8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d
  last_name: Caiazzo
  orcid: 0000-0002-4770-5388
- first_name: Jeremy
  full_name: Heyl, Jeremy
  last_name: Heyl
citation:
  ama: Caiazzo I, Heyl J. Polarization of accreting X-ray pulsars – II. Hercules X-1.
    <i>Monthly Notices of the Royal Astronomical Society</i>. 2020;501(1):129-136.
    doi:<a href="https://doi.org/10.1093/mnras/staa3429">10.1093/mnras/staa3429</a>
  apa: Caiazzo, I., &#38; Heyl, J. (2020). Polarization of accreting X-ray pulsars
    – II. Hercules X-1. <i>Monthly Notices of the Royal Astronomical Society</i>.
    Oxford University Press. <a href="https://doi.org/10.1093/mnras/staa3429">https://doi.org/10.1093/mnras/staa3429</a>
  chicago: Caiazzo, Ilaria, and Jeremy Heyl. “Polarization of Accreting X-Ray Pulsars
    – II. Hercules X-1.” <i>Monthly Notices of the Royal Astronomical Society</i>.
    Oxford University Press, 2020. <a href="https://doi.org/10.1093/mnras/staa3429">https://doi.org/10.1093/mnras/staa3429</a>.
  ieee: I. Caiazzo and J. Heyl, “Polarization of accreting X-ray pulsars – II. Hercules
    X-1,” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 501, no.
    1. Oxford University Press, pp. 129–136, 2020.
  ista: Caiazzo I, Heyl J. 2020. Polarization of accreting X-ray pulsars – II. Hercules
    X-1. Monthly Notices of the Royal Astronomical Society. 501(1), 129–136.
  mla: Caiazzo, Ilaria, and Jeremy Heyl. “Polarization of Accreting X-Ray Pulsars
    – II. Hercules X-1.” <i>Monthly Notices of the Royal Astronomical Society</i>,
    vol. 501, no. 1, Oxford University Press, 2020, pp. 129–36, doi:<a href="https://doi.org/10.1093/mnras/staa3429">10.1093/mnras/staa3429</a>.
  short: I. Caiazzo, J. Heyl, Monthly Notices of the Royal Astronomical Society 501
    (2020) 129–136.
date_created: 2024-03-26T10:34:03Z
date_published: 2020-11-05T00:00:00Z
date_updated: 2024-10-14T12:32:58Z
day: '05'
doi: 10.1093/mnras/staa3429
extern: '1'
external_id:
  arxiv:
  - '2009.00634'
intvolume: '       501'
issue: '1'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2009.00634
month: '11'
oa: 1
oa_version: Preprint
page: 129-136
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
  eissn:
  - 1365-2966
  issn:
  - 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Polarization of accreting X-ray pulsars – II. Hercules X-1
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 501
year: '2020'
...
