--- OA_place: repository OA_type: green _id: '20651' abstract: - lang: eng text: "The origin of merging binary black holes detected through gravitational waves remains a fundamental question in astrophysics. While stellar evolution imposes an upper mass limit of ∼50⁢\U0001D440⊙ for black holes, some observed mergers—most notably GW190521—involve significantly more massive components, suggesting alternative formation channels. Here we investigate the maximum masses attainable by black hole mergers within active galactic nucleus (AGN) disks. Using a comprehensive semianalytic model incorporating 27 binary and environmental parameters, we explore the role of AGN disk conditions in shaping the upper end of the black hole mass spectrum. We find that an AGN disk lifetime is the dominant factor, with high-mass mergers (≳200⁢\U0001D440⊙) only possible if disks persist for ≳40  Myr. The joint electromagnetic observation of an AGN-assisted merger could therefore lead to a direct measurement of the age of an AGN disk." acknowledgement: The authors are thankful for Yang Yang and Yue Yu for valuable discussions and assistance with the programming process. H. T. was supported by the National Key R&D Program of China (Grant No. 2021YFC2203002). Z. H. is grateful for support from NASA under Grants No. 80NSSC22K0822 and No. 80NSSC24K0440. I. B. acknowledges support from the National Science Foundation under Grant No. PHY-2309024. article_number: '063034' article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Ling Qin full_name: Xue, Ling Qin last_name: Xue - first_name: Hiromichi full_name: Tagawa, Hiromichi last_name: Tagawa - first_name: Zoltán full_name: Haiman, Zoltán id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36 last_name: Haiman orcid: 0000-0003-3633-5403 - first_name: Imre full_name: Bartos, Imre last_name: Bartos citation: ama: Xue LQ, Tagawa H, Haiman Z, Bartos I. What determines the maximum mass of AGN-assisted black hole mergers? Physical Review D. 2025;112(6). doi:10.1103/5m1n-qh9v apa: Xue, L. Q., Tagawa, H., Haiman, Z., & Bartos, I. (2025). What determines the maximum mass of AGN-assisted black hole mergers? Physical Review D. American Physical Society. https://doi.org/10.1103/5m1n-qh9v chicago: Xue, Ling Qin, Hiromichi Tagawa, Zoltán Haiman, and Imre Bartos. “What Determines the Maximum Mass of AGN-Assisted Black Hole Mergers?” Physical Review D. American Physical Society, 2025. https://doi.org/10.1103/5m1n-qh9v. ieee: L. Q. Xue, H. Tagawa, Z. Haiman, and I. Bartos, “What determines the maximum mass of AGN-assisted black hole mergers?,” Physical Review D, vol. 112, no. 6. American Physical Society, 2025. ista: Xue LQ, Tagawa H, Haiman Z, Bartos I. 2025. What determines the maximum mass of AGN-assisted black hole mergers? Physical Review D. 112(6), 063034. mla: Xue, Ling Qin, et al. “What Determines the Maximum Mass of AGN-Assisted Black Hole Mergers?” Physical Review D, vol. 112, no. 6, 063034, American Physical Society, 2025, doi:10.1103/5m1n-qh9v. short: L.Q. Xue, H. Tagawa, Z. Haiman, I. Bartos, Physical Review D 112 (2025). date_created: 2025-11-16T23:01:24Z date_published: 2025-09-18T00:00:00Z date_updated: 2025-12-01T15:29:42Z day: '18' department: - _id: ZoHa doi: 10.1103/5m1n-qh9v external_id: arxiv: - '2504.19570' isi: - '001583255800010' intvolume: ' 112' isi: 1 issue: '6' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2504.19570 month: '09' oa: 1 oa_version: Preprint publication: Physical Review D publication_identifier: eissn: - 2470-0029 issn: - 2470-0010 publication_status: published publisher: American Physical Society quality_controlled: '1' scopus_import: '1' status: public title: What determines the maximum mass of AGN-assisted black hole mergers? type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 112 year: '2025' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '20655' abstract: - lang: eng text: Traits that affect organismal fitness are often highly genetically variable. This genetic variation is vital for populations to adapt to their environments, but it is also surprising given that nature – after all – ‘selects’ the best genotypes at the expense of those that fall short. Explaining the extensive genetic variation of fitness‐related traits is thus a longstanding puzzle in evolutionary biology, with cascading implications for ecology, conservation, and human health. Balancing selection – an umbrella term for scenarios in which natural selection maintains genetic variation – is a century‐old explanation to resolve this puzzle that has gained recent momentum from genome‐scale methods for detecting it. Yet evaluating whether balancing selection can, in fact, resolve the puzzle is challenging, given the logistical constraints of distinguishing balancing selection from alternative hypotheses and the daunting collection of theoretical models that formally underpin this debate. Here, we track the development of balancing selection theory over the last century and provide an accessible review of this rich collection of models. We first outline the range of biological scenarios that can generate balancing selection. We then examine how fundamental features of genetic systems – non‐random mating between individuals, ploidy levels, genetic drift, linkage, and genetic architectures of traits – have been progressively incorporated into the theory. We end by linking these theoretical predictions to ongoing empirical efforts to understand the evolutionary processes that explain genetic variation. acknowledgement: 'We thank Brian Charlesworth, Deborah Charlesworth, and Sally Otto for extensive comments and suggestions. We also thank Göran Arnqvist, Adam Eyre-Walker, Philip Hedrick, Jitka Polechová, and Henrique Teotónio for further helpful comments on the manuscript. This work was supported by a H2020 Marie Skłodowska-Curie COFUND Action fellowship (#101034413, to F. R.), the Birgitta Sintring Foundation (#S2024-0007, to M. K. Z.), the Research Council of Norway (302619, to D. G.), the Alexander von Humboldt Foundation (to H. K.), the Swiss National Science Foundation (#211549, to X. L. R.), the Swedish Research Council (#2022-03603, to CO; #2020-03123, to E. I. S.) and the European Research Council (ERC-2023-STG-#101117517, to C. O.). We are particularly grateful to the European Society for Evolutionary Biology for funding a Special Topics Network workshop (to T. C., H. K., E. I. S.), from which this review began. Open Access funding provided by Institute of Science and Technology Austria/KEMÖ.' article_number: brv.70103 article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Filip full_name: Ruzicka, Filip id: 347955dd-57b0-11ee-9095-c28bdd368f4b last_name: Ruzicka - first_name: Martyna K. full_name: Zwoinska, Martyna K. last_name: Zwoinska - first_name: Debora full_name: Goedert, Debora last_name: Goedert - first_name: Hanna full_name: Kokko, Hanna last_name: Kokko - first_name: Xiang‐Yi full_name: Li Richter, Xiang‐Yi last_name: Li Richter - first_name: Iain R. full_name: Moodie, Iain R. last_name: Moodie - first_name: Sofie full_name: Nilén, Sofie last_name: Nilén - first_name: Colin full_name: Olito, Colin last_name: Olito - first_name: Erik I. full_name: Svensson, Erik I. last_name: Svensson - first_name: Peter full_name: Czuppon, Peter last_name: Czuppon - first_name: Tim full_name: Connallon, Tim last_name: Connallon citation: ama: Ruzicka F, Zwoinska MK, Goedert D, et al. A century of theories of balancing selection. Biological Reviews. 2025. doi:10.1111/brv.70103 apa: Ruzicka, F., Zwoinska, M. K., Goedert, D., Kokko, H., Li Richter, X., Moodie, I. R., … Connallon, T. (2025). A century of theories of balancing selection. Biological Reviews. Wiley. https://doi.org/10.1111/brv.70103 chicago: Ruzicka, Filip, Martyna K. Zwoinska, Debora Goedert, Hanna Kokko, Xiang‐Yi Li Richter, Iain R. Moodie, Sofie Nilén, et al. “A Century of Theories of Balancing Selection.” Biological Reviews. Wiley, 2025. https://doi.org/10.1111/brv.70103. ieee: F. Ruzicka et al., “A century of theories of balancing selection,” Biological Reviews. Wiley, 2025. ista: Ruzicka F, Zwoinska MK, Goedert D, Kokko H, Li Richter X, Moodie IR, Nilén S, Olito C, Svensson EI, Czuppon P, Connallon T. 2025. A century of theories of balancing selection. Biological Reviews., brv. 70103. mla: Ruzicka, Filip, et al. “A Century of Theories of Balancing Selection.” Biological Reviews, brv. 70103, Wiley, 2025, doi:10.1111/brv.70103. short: F. Ruzicka, M.K. Zwoinska, D. Goedert, H. Kokko, X. Li Richter, I.R. Moodie, S. Nilén, C. Olito, E.I. Svensson, P. Czuppon, T. Connallon, Biological Reviews (2025). corr_author: '1' date_created: 2025-11-19T09:43:50Z date_published: 2025-11-14T00:00:00Z date_updated: 2025-12-01T15:28:22Z day: '14' ddc: - '570' department: - _id: BeVi doi: 10.1111/brv.70103 ec_funded: 1 external_id: isi: - '001614285900001' pmid: - '41235821 ' has_accepted_license: '1' isi: 1 language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1111/brv.70103 month: '11' oa: 1 oa_version: Published Version pmid: 1 project: - _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c call_identifier: H2020 grant_number: '101034413' name: 'IST-BRIDGE: International postdoctoral program' publication: Biological Reviews publication_identifier: eissn: - 1469-185X issn: - 1464-7931 publication_status: epub_ahead publisher: Wiley quality_controlled: '1' scopus_import: '1' status: public title: A century of theories of balancing selection tmp: image: /images/cc_by_nc.png legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) short: CC BY-NC (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2025' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '20656' abstract: - lang: eng text: Phytohormone auxin and its directional transport mediate much of the remarkably plastic development of higher plants. Positive feedback between auxin signaling and transport is a prerequisite for (1) self-organizing processes, including vascular tissue formation, and (2) directional growth responses such as gravitropism. Here, we identify a mechanism by which auxin signaling directly targets PIN auxin transporters. Via the cell-surface AUXIN-BINDING PROTEIN1 (ABP1)-TRANSMEMBRANE KINASE 1 (TMK1) receptor module, auxin rapidly induces phosphorylation and thus stabilization of PIN2. Following gravistimulation, initial auxin asymmetry activates autophosphorylation of the TMK1 kinase. This induces TMK1 interaction with and phosphorylation of PIN2, stabilizing PIN2 at the lower root side, thus reinforcing asymmetric auxin flow for root bending. Upstream of TMK1 in this regulation, ABP1 acts redundantly with the root-expressed ABP1-LIKE 3 (ABL3) auxin receptor. Such positive feedback between cell-surface auxin signaling and PIN-mediated polar auxin transport is fundamental for robust root gravitropism and presumably for other self-organizing developmental phenomena. acknowledged_ssus: - _id: Bio - _id: LifeSc acknowledgement: We gratefully acknowledge Tongda Xu for experimental, material, and conceptual support. We thank William Gray for providing material, Nataliia Gnyliukh and Ema Cervenova for help with manuscript preparation, and Julia Schmid for help with cloning. We thank Dolf Weijers, Mark Roosjen, and Andre Kuhn for discussions and support with phospho-proteomic analyses. We thank the Bioimaging and Life Science facilities at the Institute of Science and Technology Austria (ISTA) for their excellent service and assistance. The research leading to these results has received funding from the European Union (ERC, CYNIPS, 101142681) and Austrian Science Fund (FWF; I 6123-B) to J.F., and Y.J. was funded by ERC no. 3363360-APPL under FP/2007-2013. L.R. was supported by the FP7-PEOPLE-2011-COFUND ISTFELLOW program (IC1023FELL01) and the European Molecular Biology Organization (EMBO) long-term postdoctoral fellowship (ALTF 985-2016). S.T. was supported by the National Natural Science Foundation of China (32321001, 32570366). The work of J.H. was supported by the project JG_2024_003 implemented within the Palacký University Young Researcher Grant. article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Lesia full_name: Rodriguez Solovey, Lesia id: 3922B506-F248-11E8-B48F-1D18A9856A87 last_name: Rodriguez Solovey orcid: 0000-0002-7244-7237 - first_name: Lukas full_name: Fiedler, Lukas id: 7c417475-8972-11ed-ae7b-8b674ca26986 last_name: Fiedler - first_name: Minxia full_name: Zou, Minxia id: 5c243f41-03f3-11ec-841c-96faf48a7ef9 last_name: Zou - first_name: Caterina full_name: Giannini, Caterina id: e3fdddd5-f6e0-11ea-865d-ca99ee6367f4 last_name: Giannini - first_name: Aline full_name: Monzer, Aline id: 2DB5D88C-D7B3-11E9-B8FD-7907E6697425 last_name: Monzer - first_name: Dmitrii full_name: Vladimirtsev, Dmitrii id: 60466724-5355-11ee-ae5a-fa55e8f99c3d last_name: Vladimirtsev - first_name: Marek full_name: Randuch, Marek id: 6ac4636d-15b2-11ec-abd3-fb8df79972ae last_name: Randuch - first_name: Yongfan full_name: Yu, Yongfan last_name: Yu - first_name: Zuzana full_name: Gelová, Zuzana id: 0AE74790-0E0B-11E9-ABC7-1ACFE5697425 last_name: Gelová orcid: 0000-0003-4783-1752 - first_name: Inge full_name: Verstraeten, Inge id: 362BF7FE-F248-11E8-B48F-1D18A9856A87 last_name: Verstraeten orcid: 0000-0001-7241-2328 - first_name: Jakub full_name: Hajny, Jakub id: 4800CC20-F248-11E8-B48F-1D18A9856A87 last_name: Hajny orcid: 0000-0003-2140-7195 - first_name: Meng full_name: Chen, Meng last_name: Chen - first_name: Shutang full_name: Tan, Shutang id: 2DE75584-F248-11E8-B48F-1D18A9856A87 last_name: Tan orcid: 0000-0002-0471-8285 - first_name: Lukas full_name: Hörmayer, Lukas id: 2EEE7A2A-F248-11E8-B48F-1D18A9856A87 last_name: Hörmayer orcid: 0000-0001-8295-2926 - first_name: Lanxin full_name: Li, Lanxin id: 367EF8FA-F248-11E8-B48F-1D18A9856A87 last_name: Li orcid: 0000-0002-5607-272X - first_name: Maria Mar full_name: Marques-Bueno, Maria Mar last_name: Marques-Bueno - first_name: Zainab full_name: Quddoos, Zainab id: 32ff3c64-04a0-11f0-a50f-d0c45bfac466 last_name: Quddoos - first_name: Gergely full_name: Molnar, Gergely id: 34F1AF46-F248-11E8-B48F-1D18A9856A87 last_name: Molnar - first_name: Ivan full_name: Kulich, Ivan id: 57a1567c-8314-11eb-9063-c9ddc3451a54 last_name: Kulich - first_name: Yvon full_name: Jaillais, Yvon last_name: Jaillais - first_name: Jiří full_name: Friml, Jiří id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 citation: ama: Rodriguez Solovey L, Fiedler L, Zou M, et al. ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism. Cell. 2025;188(22):6138-6150.e17. doi:10.1016/j.cell.2025.08.026 apa: Rodriguez Solovey, L., Fiedler, L., Zou, M., Giannini, C., Monzer, A., Vladimirtsev, D., … Friml, J. (2025). ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism. Cell. Elsevier. https://doi.org/10.1016/j.cell.2025.08.026 chicago: Rodriguez Solovey, Lesia, Lukas Fiedler, Minxia Zou, Caterina Giannini, Aline Monzer, Dmitrii Vladimirtsev, Marek Randuch, et al. “ABP1/ABL3-TMK1 Cell-Surface Auxin Signaling Targets PIN2-Mediated Auxin Fluxes for Root Gravitropism.” Cell. Elsevier, 2025. https://doi.org/10.1016/j.cell.2025.08.026. ieee: L. Rodriguez Solovey et al., “ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism,” Cell, vol. 188, no. 22. Elsevier, p. 6138–6150.e17, 2025. ista: Rodriguez Solovey L, Fiedler L, Zou M, Giannini C, Monzer A, Vladimirtsev D, Randuch M, Yu Y, Gelová Z, Verstraeten I, Hajny J, Chen M, Tan S, Hörmayer L, Li L, Marques-Bueno MM, Quddoos Z, Molnar G, Kulich I, Jaillais Y, Friml J. 2025. ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism. Cell. 188(22), 6138–6150.e17. mla: Rodriguez Solovey, Lesia, et al. “ABP1/ABL3-TMK1 Cell-Surface Auxin Signaling Targets PIN2-Mediated Auxin Fluxes for Root Gravitropism.” Cell, vol. 188, no. 22, Elsevier, 2025, p. 6138–6150.e17, doi:10.1016/j.cell.2025.08.026. short: L. Rodriguez Solovey, L. Fiedler, M. Zou, C. Giannini, A. Monzer, D. Vladimirtsev, M. Randuch, Y. Yu, Z. Gelová, I. Verstraeten, J. Hajny, M. Chen, S. Tan, L. Hörmayer, L. Li, M.M. Marques-Bueno, Z. Quddoos, G. Molnar, I. Kulich, Y. Jaillais, J. Friml, Cell 188 (2025) 6138–6150.e17. corr_author: '1' date_created: 2025-11-19T09:44:31Z date_published: 2025-10-30T00:00:00Z date_updated: 2025-12-01T15:27:22Z day: '30' ddc: - '580' department: - _id: JiFr - _id: XiFe doi: 10.1016/j.cell.2025.08.026 ec_funded: 1 external_id: isi: - '001616077900005' pmid: - '41043433' file: - access_level: open_access checksum: 8ac396a0806ad7f2e4e7a0c1eed712ce content_type: application/pdf creator: dernst date_created: 2025-11-24T10:55:18Z date_updated: 2025-11-24T10:55:18Z file_id: '20679' file_name: 2025_Cell_Rodriguez.pdf file_size: 17825465 relation: main_file success: 1 file_date_updated: 2025-11-24T10:55:18Z has_accepted_license: '1' intvolume: ' 188' isi: 1 issue: '22' language: - iso: eng month: '10' oa: 1 oa_version: Published Version page: 6138-6150.e17 pmid: 1 project: - _id: 8f347782-16d5-11f0-9cad-8c19706ee739 grant_number: '101142681' name: Cyclic nucleotides as second messengers in plants - _id: bd76d395-d553-11ed-ba76-f678c14f9033 grant_number: I06123 name: Peptide receptors for auxin canalization in Arabidopsis - _id: 26060676-B435-11E9-9278-68D0E5697425 grant_number: ALTF 985-2016 name: Cell surface receptor complexes for auxin signaling in plants - _id: 25681D80-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '291734' name: International IST Postdoc Fellowship Programme publication: Cell publication_identifier: issn: - 0092-8674 publication_status: published publisher: Elsevier quality_controlled: '1' related_material: record: - id: '19399' relation: earlier_version status: public status: public title: ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 188 year: '2025' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '20657' abstract: - lang: eng text: 'The Upper Bound Theorem for convex polytopes implies that the p-th Betti number of the Čech complex of any set of N points in ℝ^d and any radius satisfies β_p = O(N^m), with m = min{p+1, ⌈d/2⌉}. We construct sets in even and odd dimensions, which prove that this upper bound is asymptotically tight. For example, we describe a set of N = 2(n+1) points in ℝ³ and two radii such that the first Betti number of the Čech complex at one radius is (n+1)² - 1, and the second Betti number of the Čech complex at the other radius is n². ' acknowledgement: The first author is supported by the European Research Council (ERC), grant no. 788183, and by the DFG Collaborative Research Center TRR 109, Austrian Science Fund (FWF), grant no. I 02979-N35. The second author is supported by the European Research Council (ERC), grant “GeoScape” and by the Hungarian Science Foundation (NKFIH), grant K-131529. Both authors are supported by the Wittgenstein Prize, Austrian Science Fund (FWF), grant no. Z 342-N31. article_processing_charge: Yes (via OA deal) article_type: original arxiv: 1 author: - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 - first_name: János full_name: Pach, János id: E62E3130-B088-11EA-B919-BF823C25FEA4 last_name: Pach citation: ama: Edelsbrunner H, Pach J. Maximum Betti numbers of Čech complexes. Discrete & Computational Geometry. 2025. doi:10.1007/s00454-025-00796-5 apa: Edelsbrunner, H., & Pach, J. (2025). Maximum Betti numbers of Čech complexes. Discrete & Computational Geometry. Springer Nature. https://doi.org/10.1007/s00454-025-00796-5 chicago: Edelsbrunner, Herbert, and János Pach. “Maximum Betti Numbers of Čech Complexes.” Discrete & Computational Geometry. Springer Nature, 2025. https://doi.org/10.1007/s00454-025-00796-5. ieee: H. Edelsbrunner and J. Pach, “Maximum Betti numbers of Čech complexes,” Discrete & Computational Geometry. Springer Nature, 2025. ista: Edelsbrunner H, Pach J. 2025. Maximum Betti numbers of Čech complexes. Discrete & Computational Geometry. mla: Edelsbrunner, Herbert, and János Pach. “Maximum Betti Numbers of Čech Complexes.” Discrete & Computational Geometry, Springer Nature, 2025, doi:10.1007/s00454-025-00796-5. short: H. Edelsbrunner, J. Pach, Discrete & Computational Geometry (2025). corr_author: '1' date_created: 2025-11-19T09:44:58Z date_published: 2025-11-10T00:00:00Z date_updated: 2025-12-01T15:19:21Z day: '10' ddc: - '510' department: - _id: HeEd doi: 10.1007/s00454-025-00796-5 ec_funded: 1 external_id: arxiv: - '2310.14801' isi: - '001610592600001' has_accepted_license: '1' isi: 1 language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1007/s00454-025-00796-5 month: '11' oa: 1 oa_version: Published Version project: - _id: 266A2E9E-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '788183' name: Alpha Shape Theory Extended - _id: 2561EBF4-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: I02979-N35 name: Persistence and stability of geometric complexes - _id: 268116B8-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: Z00342 name: Mathematics, Computer Science publication: Discrete & Computational Geometry publication_identifier: eissn: - 1432-0444 issn: - 0179-5376 publication_status: epub_ahead publisher: Springer Nature quality_controlled: '1' related_material: record: - id: '17146' relation: earlier_version status: public scopus_import: '1' status: public title: Maximum Betti numbers of Čech complexes tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2025' ... --- OA_place: repository OA_type: green _id: '20658' abstract: - lang: eng text: The medial axis of a smoothly embedded surface in R^3 consists of all points for which the Euclidean distance function on the surface has at least two global minima. We generalize this notion to the mid-sphere axis, which consists of all points for which the Euclidean distance function has two interchanging saddles that swap their partners in the pairing by persistent homology. It offers a discrete-algebraic multi-scale approach to computing ridge-like structures on the surface. As a proof of concept, an algorithm that computes stair-case approximations of the mid-sphere axis is provided. alternative_title: - LNCS article_processing_charge: No arxiv: 1 author: - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 - first_name: Elizabeth R full_name: Stephenson, Elizabeth R id: 2D04F932-F248-11E8-B48F-1D18A9856A87 last_name: Stephenson orcid: 0000-0002-6862-208X - first_name: Martin H full_name: Thoresen, Martin H id: 47CB1472-F248-11E8-B48F-1D18A9856A87 last_name: Thoresen citation: ama: 'Edelsbrunner H, Stephenson ER, Thoresen MH. The mid-sphere cousin of the medial axis transform. In: 4th International Joint Conference on Discrete Geometry and Mathematical Morphology. Vol 16296. Springer Nature; 2025:133-147. doi:10.1007/978-3-032-09544-2_10' apa: 'Edelsbrunner, H., Stephenson, E. R., & Thoresen, M. H. (2025). The mid-sphere cousin of the medial axis transform. In 4th International Joint Conference on Discrete Geometry and Mathematical Morphology (Vol. 16296, pp. 133–147). Groningen, The Netherlands: Springer Nature. https://doi.org/10.1007/978-3-032-09544-2_10' chicago: Edelsbrunner, Herbert, Elizabeth R Stephenson, and Martin H Thoresen. “The Mid-Sphere Cousin of the Medial Axis Transform.” In 4th International Joint Conference on Discrete Geometry and Mathematical Morphology, 16296:133–47. Springer Nature, 2025. https://doi.org/10.1007/978-3-032-09544-2_10. ieee: H. Edelsbrunner, E. R. Stephenson, and M. H. Thoresen, “The mid-sphere cousin of the medial axis transform,” in 4th International Joint Conference on Discrete Geometry and Mathematical Morphology, Groningen, The Netherlands, 2025, vol. 16296, pp. 133–147. ista: 'Edelsbrunner H, Stephenson ER, Thoresen MH. 2025. The mid-sphere cousin of the medial axis transform. 4th International Joint Conference on Discrete Geometry and Mathematical Morphology. DGMM: Discrete Geometry and Mathematical Morphology, LNCS, vol. 16296, 133–147.' mla: Edelsbrunner, Herbert, et al. “The Mid-Sphere Cousin of the Medial Axis Transform.” 4th International Joint Conference on Discrete Geometry and Mathematical Morphology, vol. 16296, Springer Nature, 2025, pp. 133–47, doi:10.1007/978-3-032-09544-2_10. short: H. Edelsbrunner, E.R. Stephenson, M.H. Thoresen, in:, 4th International Joint Conference on Discrete Geometry and Mathematical Morphology, Springer Nature, 2025, pp. 133–147. conference: end_date: 2025-11-06 location: Groningen, The Netherlands name: 'DGMM: Discrete Geometry and Mathematical Morphology' start_date: 2025-11-03 date_created: 2025-11-23T23:01:37Z date_published: 2025-11-01T00:00:00Z date_updated: 2025-11-24T10:05:11Z day: '01' department: - _id: HeEd doi: 10.1007/978-3-032-09544-2_10 external_id: arxiv: - '2504.14743' intvolume: ' 16296' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2504.14743 month: '11' oa: 1 oa_version: Preprint page: 133-147 publication: 4th International Joint Conference on Discrete Geometry and Mathematical Morphology publication_identifier: eissn: - 1611-3349 isbn: - '9783032095435' issn: - 0302-9743 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: The mid-sphere cousin of the medial axis transform type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 16296 year: '2025' ... --- OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '20659' abstract: - lang: eng text: "Metabotropic GABA (GABAB) receptors have modulatory functions on neuronal excitability and\r\nneurotransmitter release. To fulfil these functions, GABAB receptors form macromolecular signaling complexes with G proteins, effectors, and other associated proteins. Here we investigated the postnatal development of GABAB receptors (GABAB1 and GABAB2 subunits) in mouse brain, focusing on potential similarities in the spatial and temporal expression pattern\r\nof their associated proteins CaV2.1, Gαo, Gβ5, and RGS7, using histoblots, immunofluorescence, and immunoelectron microscopic techniques. At all ages analyzed, histoblot showed that the six proteins were widely expressed in the brain, with mostly an\r\noverlapping pattern throughout postnatal development. In the hippocampus, immunoelectron microscopy and quantitative analysis of immunoparticles for GABAB1, GABAB2, Gαo, Gβ5, and RGS7 revealed their progressive enrichment around excitatory synapses on dendritic spines of CA1 pyramidal cells toward P15. At presynaptic sites, GABAB receptors colocalize with\r\nCaV2.1, Gαo, Gβ5, and RGS7 in the active zone and extrasynaptic membranes of axon terminals, establishing synapses on dendritic spines of CA1 pyramidal cells. In the cerebellum, double immunofluorescence at P7 and P10 revealed the colocalization of GABAB1 and CaV2.1\r\nin the whole dendritic tree of developing Purkinje cells. Immunoelectron microscopy at P15 showed that GABAB1, GABAB2, CaV2.1, Gαo, Gβ5, and RGS7 are distributed along the dendritic surface of Purkinje cells, enriched close to excitatory synapses in spines.\r\nAltogether, these data suggest that macromolecular complexes composed of GABAB1 /GABAB2/CaV2.1/ Gαo/Gβ5/RGS7 are pre-assembled during key stages of postnatal development in hippocampal and cerebellar neurons." acknowledgement: We thank Ms. Diane Latawiec for the English revision of the manuscript. Funding sources were the Spanish Ministerio de Economía y Competitividad, and Junta de Comunidades de CastillaLa Mancha (Spain). Grants PID2021-125875OB-I00 funded by MCIN/AEI/ 10.13039/501100011033 and “ERDF A way of making Europe” to RL. This work was also supported by Castilla-La Mancha Regional Government and the European Regional Development Fund (SBPLY/21/180501/000064) and the Universidad de Castilla-La Mancha (2023-GRIN-34187) to RL. article_processing_charge: Yes article_type: original author: - first_name: Carolina full_name: Aguado, Carolina last_name: Aguado - first_name: Rocío full_name: Alfaro-Ruiz, Rocío last_name: Alfaro-Ruiz - first_name: María Llanos full_name: Martínez-Poyato, María Llanos last_name: Martínez-Poyato - first_name: Ana Esther full_name: Moreno-Martínez, Ana Esther last_name: Moreno-Martínez - first_name: Sebastián full_name: García-Madrona, Sebastián last_name: García-Madrona - first_name: Alberto full_name: Roldán-Sastre, Alberto last_name: Roldán-Sastre - first_name: Pablo full_name: Alonso-Gómez, Pablo last_name: Alonso-Gómez - first_name: Miriam full_name: Fernández, Miriam last_name: Fernández - first_name: Ricardo full_name: Puertas-Avendaño, Ricardo last_name: Puertas-Avendaño - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Kirill A. full_name: Martemyanov, Kirill A. last_name: Martemyanov - first_name: Rafael full_name: Luján, Rafael last_name: Luján citation: ama: Aguado C, Alfaro-Ruiz R, Martínez-Poyato ML, et al. Developmental regulation of GABAB receptors and downstream molecules in the mouse brain. Histology and Histopathology. 2025;40(12):1967-1984. doi:10.14670/HH-18-970 apa: Aguado, C., Alfaro-Ruiz, R., Martínez-Poyato, M. L., Moreno-Martínez, A. E., García-Madrona, S., Roldán-Sastre, A., … Luján, R. (2025). Developmental regulation of GABAB receptors and downstream molecules in the mouse brain. Histology and Histopathology. Sercrisma International. https://doi.org/10.14670/HH-18-970 chicago: Aguado, Carolina, Rocío Alfaro-Ruiz, María Llanos Martínez-Poyato, Ana Esther Moreno-Martínez, Sebastián García-Madrona, Alberto Roldán-Sastre, Pablo Alonso-Gómez, et al. “Developmental Regulation of GABAB Receptors and Downstream Molecules in the Mouse Brain.” Histology and Histopathology. Sercrisma International, 2025. https://doi.org/10.14670/HH-18-970. ieee: C. Aguado et al., “Developmental regulation of GABAB receptors and downstream molecules in the mouse brain,” Histology and Histopathology, vol. 40, no. 12. Sercrisma International, pp. 1967–1984, 2025. ista: Aguado C, Alfaro-Ruiz R, Martínez-Poyato ML, Moreno-Martínez AE, García-Madrona S, Roldán-Sastre A, Alonso-Gómez P, Fernández M, Puertas-Avendaño R, Shigemoto R, Martemyanov KA, Luján R. 2025. Developmental regulation of GABAB receptors and downstream molecules in the mouse brain. Histology and Histopathology. 40(12), 1967–1984. mla: Aguado, Carolina, et al. “Developmental Regulation of GABAB Receptors and Downstream Molecules in the Mouse Brain.” Histology and Histopathology, vol. 40, no. 12, Sercrisma International, 2025, pp. 1967–84, doi:10.14670/HH-18-970. short: C. Aguado, R. Alfaro-Ruiz, M.L. Martínez-Poyato, A.E. Moreno-Martínez, S. García-Madrona, A. Roldán-Sastre, P. Alonso-Gómez, M. Fernández, R. Puertas-Avendaño, R. Shigemoto, K.A. Martemyanov, R. Luján, Histology and Histopathology 40 (2025) 1967–1984. date_created: 2025-11-23T23:01:37Z date_published: 2025-12-01T00:00:00Z date_updated: 2025-11-24T10:24:35Z day: '01' ddc: - '570' department: - _id: RySh doi: 10.14670/HH-18-970 external_id: pmid: - '40704638' file: - access_level: open_access checksum: 779d67434400c0f94af42c35ba21c672 content_type: application/pdf creator: dernst date_created: 2025-11-24T10:23:39Z date_updated: 2025-11-24T10:23:39Z file_id: '20677' file_name: 2025_HistologyHistopathology_Aguado.pdf file_size: 18093266 relation: main_file success: 1 file_date_updated: 2025-11-24T10:23:39Z has_accepted_license: '1' intvolume: ' 40' issue: '12' language: - iso: eng month: '12' oa: 1 oa_version: Published Version page: 1967-1984 pmid: 1 publication: Histology and Histopathology publication_identifier: eissn: - 1699-5848 publication_status: published publisher: Sercrisma International quality_controlled: '1' scopus_import: '1' status: public title: Developmental regulation of GABAB receptors and downstream molecules in the mouse brain tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 40 year: '2025' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '20660' abstract: - lang: eng text: "We used observations from the JWST Emission Line Survey (JELS) to measure the half-light radii (re) of 23 Hα-emitting starforming (SF) galaxies at z = 6.1 in the PRIMER/COSMOS field. Galaxy sizes were measured in JWST near-infrared camera observations in rest-frame Hα (tracing recent star formation) with the F466N and F470N narrow-band filters from JELS, and\r\ncompared against rest-R- and V -band (tracing established stellar populations) and near-ultraviolet sizes. We find a size–stellar mass(re − M∗) relationship with a slope that is consistent with literature values at lower redshifts, though offset to lowersizes. We observe a large scatter in re at low stellar mass (M∗ < 10^8.4 Mo) which we believe is the result of bursty star formation histories (SFHs) of SF galaxies at the Epoch of Reionization (EoR). We find that the stellar and ionized gas components are similar in size at z = 6.1. The evidence of already-established stellar components in these Hα emitters (HAEs) indicates previous episodes of star formation have occurred. As such, following other JELS studies finding our HAEs are undergoing a current burst of star formation, we believe our results indicate that SF galaxies at the end of the EoR have already experienced a bursty SFH. From our re − M∗ relationship, we find re,F444W = 0.76 ± 0.46 kpc for fixed stellar mass M∗ = 10^9.25 M, which is in agreement with other observations and simulations of SF galaxies in the literature. We find a close-pair (major) merger fraction of (fmaj. merger =0.44 ± 0.22) fmerger = 0.43 ± 0.11 for galaxy separations d <~ 25 kpc, which is in agreement with other z ≈ 6 studies." acknowledgement: "This work makes use of ASTROPY, 7 a community-developed core PYTHON package for Astronomy (Astropy Collaboration 2013, 2018, 2022), as well as the NUMPY (C. R. Harris et al. 2020) and SCIPY (P.Virtanen et al. 2020) packages(see also T. E. Oliphant 2007). All plots\r\nwere created using the MATPLOTLIB 2D graphics PYTHON package (J. D. Hunter 2007). Conversions between redshift and lookback time in our selected cosmological model were done using the Javascript cosmological calculator from E. L. Wright (2006).8 The authors would like to thank the anonymous referee for their constructive comments and suggestions which have strengthened the analysis of this work and improved the paper. The authors also gratefully acknowledge Ian Smail for providing valuable feedback and helping to guide the science of this paper. This work is based on observations made with the NASA/ESA/CSA James Webb Space\r\nTelescope. The data were obtained from the Mikulski Archive for Space Telescopes9 at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations are associated with programs GO no. 2321 (JELS) and GO no. 1837 (PRIMER). The authors acknowledge the PRIMER team for developing their observing program with a zero-exclusive-access period. HMOS acknowledges support from an STFC PhD studentship and the Faculty of Science and Technology at Lancaster University. PNB is grateful for support from the UK STFC\r\nvia grants ST/V000594/1 and ST/Y000951/1. JSD acknowledges the support of the Royal Society via a Royal Society Research Professorship. LOF acknowledges funding by ANID BECAS/DOCTORADO NACIONAL 21220499.CLH acknowledges support from the Oxford\r\nHintze Centre for Astrophysical Surveys which is funded through generous support from the Hintze family charity foundation. EI gratefully acknowledge financial support from ANID – MILENIO –NCN2024 112 and ANID FONDECYT Regular 1221846. For the purpose of open access, the authors have applied a Creative Commons attribution (CC BY) licence to any author accepted manuscript version arising." article_processing_charge: Yes article_type: original author: - first_name: H. M.O. full_name: Stephenson, H. M.O. last_name: Stephenson - first_name: J. P. full_name: Stott, J. P. last_name: Stott - first_name: C. A. full_name: Pirie, C. A. last_name: Pirie - first_name: K. J. full_name: Duncan, K. J. last_name: Duncan - first_name: D. J. full_name: Mcleod, D. J. last_name: Mcleod - first_name: P. N. full_name: Best, P. N. last_name: Best - first_name: M. full_name: Brinch, M. last_name: Brinch - first_name: M. full_name: Clausen, M. last_name: Clausen - first_name: R. K. full_name: Cochrane, R. K. last_name: Cochrane - first_name: J. S. full_name: Dunlop, J. S. last_name: Dunlop - first_name: S. R. full_name: Flury, S. R. last_name: Flury - first_name: J. E. full_name: Geach, J. E. last_name: Geach - first_name: C. L. full_name: Hale, C. L. last_name: Hale - first_name: E. full_name: Ibar, E. last_name: Ibar - first_name: Zefeng full_name: Li, Zefeng last_name: Li - first_name: Jorryt J full_name: Matthee, Jorryt J id: 7439a258-f3c0-11ec-9501-9df22fe06720 last_name: Matthee orcid: 0000-0003-2871-127X - first_name: R. J. full_name: Mclure, R. J. last_name: Mclure - first_name: L. full_name: Ossa-Fuentes, L. last_name: Ossa-Fuentes - first_name: A. L. full_name: Patrick, A. L. last_name: Patrick - first_name: D. full_name: Sobral, D. last_name: Sobral - first_name: A. M. full_name: Swinbank, A. M. last_name: Swinbank citation: ama: 'Stephenson HMO, Stott JP, Pirie CA, et al. The JWST Emission Line Survey (JELS): The sizes and merger fraction of star-forming galaxies during the Epoch of Reionization. Monthly Notices of the Royal Astronomical Society. 2025;544(2):1412-1431. doi:10.1093/mnras/staf1725' apa: 'Stephenson, H. M. O., Stott, J. P., Pirie, C. A., Duncan, K. J., Mcleod, D. J., Best, P. N., … Swinbank, A. M. (2025). The JWST Emission Line Survey (JELS): The sizes and merger fraction of star-forming galaxies during the Epoch of Reionization. Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/staf1725' chicago: 'Stephenson, H. M.O., J. P. Stott, C. A. Pirie, K. J. Duncan, D. J. Mcleod, P. N. Best, M. Brinch, et al. “The JWST Emission Line Survey (JELS): The Sizes and Merger Fraction of Star-Forming Galaxies during the Epoch of Reionization.” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2025. https://doi.org/10.1093/mnras/staf1725.' ieee: 'H. M. O. Stephenson et al., “The JWST Emission Line Survey (JELS): The sizes and merger fraction of star-forming galaxies during the Epoch of Reionization,” Monthly Notices of the Royal Astronomical Society, vol. 544, no. 2. Oxford University Press, pp. 1412–1431, 2025.' ista: 'Stephenson HMO, Stott JP, Pirie CA, Duncan KJ, Mcleod DJ, Best PN, Brinch M, Clausen M, Cochrane RK, Dunlop JS, Flury SR, Geach JE, Hale CL, Ibar E, Li Z, Matthee JJ, Mclure RJ, Ossa-Fuentes L, Patrick AL, Sobral D, Swinbank AM. 2025. The JWST Emission Line Survey (JELS): The sizes and merger fraction of star-forming galaxies during the Epoch of Reionization. Monthly Notices of the Royal Astronomical Society. 544(2), 1412–1431.' mla: 'Stephenson, H. M. O., et al. “The JWST Emission Line Survey (JELS): The Sizes and Merger Fraction of Star-Forming Galaxies during the Epoch of Reionization.” Monthly Notices of the Royal Astronomical Society, vol. 544, no. 2, Oxford University Press, 2025, pp. 1412–31, doi:10.1093/mnras/staf1725.' short: H.M.O. Stephenson, J.P. Stott, C.A. Pirie, K.J. Duncan, D.J. Mcleod, P.N. Best, M. Brinch, M. Clausen, R.K. Cochrane, J.S. Dunlop, S.R. Flury, J.E. Geach, C.L. Hale, E. Ibar, Z. Li, J.J. Matthee, R.J. Mclure, L. Ossa-Fuentes, A.L. Patrick, D. Sobral, A.M. Swinbank, Monthly Notices of the Royal Astronomical Society 544 (2025) 1412–1431. date_created: 2025-11-23T23:01:37Z date_published: 2025-12-01T00:00:00Z date_updated: 2025-12-01T15:25:11Z day: '01' ddc: - '520' department: - _id: JoMa doi: 10.1093/mnras/staf1725 external_id: isi: - '001611415800001' file: - access_level: open_access checksum: ddb3f429d2246bbf536efb4b0e52f3a8 content_type: application/pdf creator: dernst date_created: 2025-11-24T10:35:15Z date_updated: 2025-11-24T10:35:15Z file_id: '20678' file_name: 2025_MonthlyNoticesRAS_Stephenson.pdf file_size: 3625308 relation: main_file success: 1 file_date_updated: 2025-11-24T10:35:15Z has_accepted_license: '1' intvolume: ' 544' isi: 1 issue: '2' language: - iso: eng month: '12' oa: 1 oa_version: Published Version page: 1412-1431 publication: Monthly Notices of the Royal Astronomical Society publication_identifier: eissn: - 1365-2966 issn: - 0035-8711 publication_status: published publisher: Oxford University Press quality_controlled: '1' scopus_import: '1' status: public title: 'The JWST Emission Line Survey (JELS): The sizes and merger fraction of star-forming galaxies during the Epoch of Reionization' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 544 year: '2025' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '20661' abstract: - lang: eng text: "We analyse James Webb Space Telescope (JWST) Near Infrared Imager and Slitless Spectrograph (NIRISS) and Near Infrared Spectrograph (NIRSpec) spectroscopic observations in the Abell 2744 galaxy cluster field. From approximately 120 candidates, we identify 12 objects with at least two prominent emission lines among [O II] λ3727, H β λ4861, [O III] λ4959, [O III] λ5007, and H α λ6563 that are spectroscopically confirmed by both instruments. Our key findings reveal systematic differences between the two spectrographs based on source morphology and shutter aperture placement. Compact objects show comparable or higher\r\nintegrated flux in NIRSpec relative to NIRISS (within 1σ uncertainties), while extended sources consistently display higher flux in NIRISS measurements. This pattern reflects NIRSpec’s optimal coverage for compact objects while potentially undersampling extended sources. Quantitative analysis demonstrates that NIRSpec recovers at least 63 per cent of NIRISS-measured flux when the slit covers >15 per cent of the source or when Re < 1 kpc. For lower coverage or larger effective radii, the recovered flux varies from 24 per cent to 63 per cent. When studying the H α λ6563/[O III] λ5007 emission line ratio, we observe that\r\nmeasurements from these different spectrographs can vary by up to ∼0.3 dex, with significant implications for metallicity and star formation rate characterizations for individual galaxies. These results highlight the importance of considering instrumental effects when combining multi-instrument spectroscopic data and demonstrate that source morphology critically influences flux\r\nrecovery between slit-based and slitless spectroscopic modes in JWST observations." acknowledgement: "This research was supported in part by the Australian Research Council Centre of Excellence for All Sky Astrophysics in 3 Dimensions (ASTRO 3D), through project number CE170100013. This research was supported in part by The Dr Albert Shimmins Fund through the Albert Shimmins Postgraduate Writing Up Award (University of Melbourne). This work is based on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5–03127 for JWST. These observations are associated with programmes JWST-ERS-1324, JWST-GO-2561, and JWST-DDT-2756. BV and PW acknowledge support from the INAF Large Grant 2022 ‘Extragalactic Surveys with JWST’ (PI Pentericci), the INAF Mini\r\nGrant ‘1.05.24.07.01 RSN1: Spatially-Resolved Near-IR Emission of Intermediate-Redshift Jellyfish Galaxies’ (PI Watson), and are supported by the European Union – NextGenerationEU RFF M4C2 1.1 PRIN 2022 project 2022ZSL4BL INSIGHT. MB acknowledges support from the ERC Advanced Grant FIRSTLIGHT and Slovenian national research agency ARIS through grants N1-0238 and P1-0188. " article_processing_charge: Yes article_type: original arxiv: 1 author: - first_name: Nicolò full_name: Dalmasso, Nicolò last_name: Dalmasso - first_name: Peter J. full_name: Watson, Peter J. last_name: Watson - first_name: Tommaso full_name: Treu, Tommaso last_name: Treu - first_name: Michele full_name: Trenti, Michele last_name: Trenti - first_name: Benedetta full_name: Vulcani, Benedetta last_name: Vulcani - first_name: Themiya full_name: Nanayakkara, Themiya last_name: Nanayakkara - first_name: Maruša full_name: Bradač, Maruša last_name: Bradač - first_name: Tucker full_name: Jones, Tucker last_name: Jones - first_name: Kristan full_name: Boyett, Kristan last_name: Boyett - first_name: Xin full_name: Wang, Xin last_name: Wang - first_name: Sara full_name: Mascia, Sara id: edaf889c-c7cd-11ef-ab1b-bb28c431bd29 last_name: Mascia - first_name: Laura full_name: Pentericci, Laura last_name: Pentericci citation: ama: 'Dalmasso N, Watson PJ, Treu T, et al. Quantifying spectroscopic flux variations between JWST NIRISS and NIRSpec: Slit losses in emission line measurements of z ∼ 1-3 galaxies. Monthly Notices of the Royal Astronomical Society. 2025;544(2):1915-1925. doi:10.1093/mnras/staf1837' apa: 'Dalmasso, N., Watson, P. J., Treu, T., Trenti, M., Vulcani, B., Nanayakkara, T., … Pentericci, L. (2025). Quantifying spectroscopic flux variations between JWST NIRISS and NIRSpec: Slit losses in emission line measurements of z ∼ 1-3 galaxies. Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/staf1837' chicago: 'Dalmasso, Nicolò, Peter J. Watson, Tommaso Treu, Michele Trenti, Benedetta Vulcani, Themiya Nanayakkara, Maruša Bradač, et al. “Quantifying Spectroscopic Flux Variations between JWST NIRISS and NIRSpec: Slit Losses in Emission Line Measurements of z ∼ 1-3 Galaxies.” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2025. https://doi.org/10.1093/mnras/staf1837.' ieee: 'N. Dalmasso et al., “Quantifying spectroscopic flux variations between JWST NIRISS and NIRSpec: Slit losses in emission line measurements of z ∼ 1-3 galaxies,” Monthly Notices of the Royal Astronomical Society, vol. 544, no. 2. Oxford University Press, pp. 1915–1925, 2025.' ista: 'Dalmasso N, Watson PJ, Treu T, Trenti M, Vulcani B, Nanayakkara T, Bradač M, Jones T, Boyett K, Wang X, Mascia S, Pentericci L. 2025. Quantifying spectroscopic flux variations between JWST NIRISS and NIRSpec: Slit losses in emission line measurements of z ∼ 1-3 galaxies. Monthly Notices of the Royal Astronomical Society. 544(2), 1915–1925.' mla: 'Dalmasso, Nicolò, et al. “Quantifying Spectroscopic Flux Variations between JWST NIRISS and NIRSpec: Slit Losses in Emission Line Measurements of z ∼ 1-3 Galaxies.” Monthly Notices of the Royal Astronomical Society, vol. 544, no. 2, Oxford University Press, 2025, pp. 1915–25, doi:10.1093/mnras/staf1837.' short: N. Dalmasso, P.J. Watson, T. Treu, M. Trenti, B. Vulcani, T. Nanayakkara, M. Bradač, T. Jones, K. Boyett, X. Wang, S. Mascia, L. Pentericci, Monthly Notices of the Royal Astronomical Society 544 (2025) 1915–1925. date_created: 2025-11-23T23:01:38Z date_published: 2025-12-01T00:00:00Z date_updated: 2025-12-01T15:23:21Z day: '01' ddc: - '520' department: - _id: JoMa doi: 10.1093/mnras/staf1837 external_id: arxiv: - '2510.27036' isi: - '001615620500001' file: - access_level: open_access checksum: 2caff0a3b81fed114408377323298b43 content_type: application/pdf creator: dernst date_created: 2025-11-24T09:02:04Z date_updated: 2025-11-24T09:02:04Z file_id: '20674' file_name: 2025_MonthlyNoticesRAS_Dalmasso.pdf file_size: 1952887 relation: main_file success: 1 file_date_updated: 2025-11-24T09:02:04Z has_accepted_license: '1' intvolume: ' 544' isi: 1 issue: '2' language: - iso: eng month: '12' oa: 1 oa_version: Published Version page: 1915-1925 publication: Monthly Notices of the Royal Astronomical Society publication_identifier: eissn: - 1365-2966 issn: - 0035-8711 publication_status: published publisher: Oxford University Press quality_controlled: '1' scopus_import: '1' status: public title: 'Quantifying spectroscopic flux variations between JWST NIRISS and NIRSpec: Slit losses in emission line measurements of z ∼ 1-3 galaxies' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 544 year: '2025' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '20662' abstract: - lang: eng text: Task-based functional magnetic resonance imaging (fMRI) reveals individual differences in neural correlates of cognition but faces scalability challenges due to cognitive demands, protocol variability, and limited task coverage in large datasets. Here, we propose DeepTaskGen, a deep-learning approach that synthesizes non-acquired task-based contrast maps from resting-state (rs-) fMRI. We validate this approach using the Human Connectome Project lifespan data, then generate 47 contrast maps from 7 different cognitive tasks for over 20,000 individuals from UK Biobank. DeepTaskGen outperforms several benchmarks in generating synthetic task-contrast maps, achieving superior reconstruction performance while retaining inter-individual variation essential for biomarker development. We further show comparable or superior predictive performance of synthetic maps relative to actual maps and rs-connectomes across diverse demographic, cognitive, and clinical variables. This approach facilitates the study of individual differences and the generation of task-related biomarkers by enabling the generation of arbitrary functional cognitive tasks from readily available rs-fMRI data. acknowledgement: 'Funded by the European Union (Grant agreement No 101057429). Complementary funding was received by UK Research and Innovation (UKRI) under the UK government’s Horizon Europe funding guarantee (10131373 and 10038599) and the National Key R&D Program of Ministry of Science and Technology of China (MOST 2023YFE0199700). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union, the European Health and Digital Executive Agency (HADEA), UKRI or MOST. Neither the European Union nor HADEA nor UKRI nor MOST can be held responsible for them. This work has also been supported by a Grant from the German Research Foundation to the ENIGMA task-based fMRI Working Group (DFG ER 724/4–1, WA 1539/11–1). Data used in this study were provided in part by the Human Connectome Project, WU-Minn Consortium (principal investigators: D. Van Essen and K. Ugurbil; grant number 1U54MH091657), funded by the 16 National Institutes of Health (NIH) institutes and centers supporting the NIH Blueprint for Neuroscience Research, and by the McDonnell Center for Systems Neuroscience at Washington University. Additionally, this research utilized data obtained from UK Biobank, a large-scale biomedical database. Open Access funding enabled and organized by Projekt DEAL.' article_number: '1572' article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Emin full_name: Serin, Emin last_name: Serin - first_name: Kerstin full_name: Ritter, Kerstin last_name: Ritter - first_name: Gunter full_name: Schumann, Gunter last_name: Schumann - first_name: Tobias full_name: Banaschewski, Tobias last_name: Banaschewski - first_name: Andre full_name: Marquand, Andre last_name: Marquand - first_name: Henrik full_name: Walter, Henrik last_name: Walter - first_name: George full_name: Ogoh, George last_name: Ogoh - first_name: Bernd Carsten full_name: Stahl, Bernd Carsten last_name: Stahl - first_name: Ragnhild full_name: Brandlistuen, Ragnhild last_name: Brandlistuen - first_name: Tamara full_name: Schikowski, Tamara last_name: Schikowski - first_name: Allan H. full_name: Young, Allan H. last_name: Young - first_name: Yu full_name: Xinyang, Yu last_name: Xinyang - first_name: Zuo full_name: Zhang, Zuo last_name: Zhang - first_name: Kofoworola full_name: Agunbiade, Kofoworola last_name: Agunbiade - first_name: Di full_name: Chen, Di last_name: Chen - first_name: Sylvane full_name: Desrivières, Sylvane last_name: Desrivières - first_name: Nicholas full_name: Clinton, Nicholas last_name: Clinton - first_name: Paul full_name: Thompson, Paul last_name: Thompson - first_name: Venessa full_name: Köhler, Venessa last_name: Köhler - first_name: Ameli full_name: Schwalber, Ameli last_name: Schwalber - first_name: Vince D. full_name: Calhoun, Vince D. last_name: Calhoun - first_name: Xiao full_name: Chang, Xiao last_name: Chang - first_name: Yanqing full_name: Zhang, Yanqing last_name: Zhang - first_name: Yuzhu full_name: Li, Yuzhu last_name: Li - first_name: Yuxiang full_name: Dai, Yuxiang last_name: Dai - first_name: Jiacan full_name: Yuan, Jiacan last_name: Yuan - first_name: Yunman full_name: Xia, Yunman last_name: Xia - first_name: Tianye full_name: Jia, Tianye last_name: Jia - first_name: Paul full_name: Renner, Paul last_name: Renner - first_name: Sören full_name: Hese, Sören last_name: Hese - first_name: Bernhard full_name: Spanlang, Bernhard last_name: Spanlang - first_name: Charlie full_name: Pearmund, Charlie last_name: Pearmund - first_name: Anastasios Polykarpos full_name: Athanasiadis, Anastasios Polykarpos last_name: Athanasiadis - first_name: Spase full_name: Petkoski, Spase last_name: Petkoski - first_name: Viktor full_name: Jirsa, Viktor last_name: Jirsa - first_name: Karen full_name: Schmitt, Karen last_name: Schmitt - first_name: Johannes H. full_name: Wilbertz, Johannes H. last_name: Wilbertz - first_name: Myrto full_name: Patraskaki, Myrto last_name: Patraskaki - first_name: Peter full_name: Sommer, Peter last_name: Sommer - first_name: Stefanie full_name: Heilmann-Heimbach, Stefanie last_name: Heilmann-Heimbach - first_name: Carina M. full_name: Mathey, Carina M. last_name: Mathey - first_name: Abigail J. full_name: Miller, Abigail J. last_name: Miller - first_name: Isabelle full_name: Claus, Isabelle last_name: Claus - first_name: Markus M. full_name: Nöthen, Markus M. last_name: Nöthen - first_name: Per full_name: Hoffmann, Per last_name: Hoffmann - first_name: Andreas J. full_name: Forstner, Andreas J. last_name: Forstner - first_name: Alvaro full_name: Pastor, Alvaro last_name: Pastor - first_name: Jaime full_name: Gallego, Jaime last_name: Gallego - first_name: Reiya full_name: Itatani, Reiya last_name: Itatani - first_name: Francisco full_name: Eiroa-Orosa, Francisco last_name: Eiroa-Orosa - first_name: Guillem full_name: Feixas, Guillem last_name: Feixas - first_name: Mel full_name: Slater, Mel last_name: Slater - first_name: Gaia full_name: Novarino, Gaia id: 3E57A680-F248-11E8-B48F-1D18A9856A87 last_name: Novarino orcid: 0000-0002-7673-7178 - first_name: Sarah Jane full_name: Böttger, Sarah Jane last_name: Böttger - first_name: Mira full_name: Tschorn, Mira last_name: Tschorn - first_name: Michael full_name: Rapp, Michael last_name: Rapp - first_name: Helga full_name: Ask, Helga last_name: Ask - first_name: Rikka full_name: Kjelkenes, Rikka last_name: Kjelkenes - first_name: Sara full_name: Fernandez, Sara last_name: Fernandez - first_name: Dennis full_name: Van Der Meer, Dennis last_name: Van Der Meer - first_name: Lars T. full_name: Westlye, Lars T. last_name: Westlye - first_name: Ole A. full_name: Andreassen, Ole A. last_name: Andreassen - first_name: Rieke full_name: Aden, Rieke last_name: Aden - first_name: Beke full_name: Seefried, Beke last_name: Seefried - first_name: Frauke full_name: Nees, Frauke last_name: Nees - first_name: Maja full_name: Neidhart, Maja last_name: Neidhart - first_name: Argyris full_name: Stringaris, Argyris last_name: Stringaris - first_name: Emanuel full_name: Schwarz, Emanuel last_name: Schwarz - first_name: Nathalie full_name: Holz, Nathalie last_name: Holz - first_name: Heike full_name: Tost, Heike last_name: Tost - first_name: Andreas full_name: Meyer-Lindenberg, Andreas last_name: Meyer-Lindenberg - first_name: Nina full_name: Christmann, Nina last_name: Christmann - first_name: Karina full_name: Janson, Karina last_name: Janson - first_name: Kerstin full_name: Schepanski, Kerstin last_name: Schepanski - first_name: Tatjana full_name: Schütz, Tatjana last_name: Schütz - first_name: Ulrike Helene full_name: Taron, Ulrike Helene last_name: Taron - first_name: Roland full_name: Eils, Roland last_name: Eils - first_name: Jean Charles full_name: Roy, Jean Charles last_name: Roy - first_name: Tristram A. full_name: Lett, Tristram A. last_name: Lett - first_name: Hedi full_name: Kebir, Hedi last_name: Kebir - first_name: Elli full_name: Polemiti, Elli last_name: Polemiti - first_name: Esther full_name: Hitchen, Esther last_name: Hitchen - first_name: Marcel full_name: Jentsch, Marcel last_name: Jentsch - first_name: Emin full_name: Serin, Emin last_name: Serin - first_name: Antoine full_name: Bernas, Antoine last_name: Bernas - first_name: Nilakshi full_name: Vaidya, Nilakshi last_name: Vaidya - first_name: Sven full_name: Twardziok, Sven last_name: Twardziok - first_name: Markus full_name: Ralser, Markus last_name: Ralser - first_name: Andreas full_name: Heinz, Andreas last_name: Heinz - first_name: Gunter full_name: Schumann, Gunter last_name: Schumann citation: ama: Serin E, Ritter K, Schumann G, et al. Generating synthetic task-based brain fingerprints for population neuroscience using deep learning. Communications Biology. 2025;8. doi:10.1038/s42003-025-09158-6 apa: Serin, E., Ritter, K., Schumann, G., Banaschewski, T., Marquand, A., Walter, H., … Schumann, G. (2025). Generating synthetic task-based brain fingerprints for population neuroscience using deep learning. Communications Biology. Springer Nature. https://doi.org/10.1038/s42003-025-09158-6 chicago: Serin, Emin, Kerstin Ritter, Gunter Schumann, Tobias Banaschewski, Andre Marquand, Henrik Walter, George Ogoh, et al. “Generating Synthetic Task-Based Brain Fingerprints for Population Neuroscience Using Deep Learning.” Communications Biology. Springer Nature, 2025. https://doi.org/10.1038/s42003-025-09158-6. ieee: E. Serin et al., “Generating synthetic task-based brain fingerprints for population neuroscience using deep learning,” Communications Biology, vol. 8. Springer Nature, 2025. ista: Serin E, Ritter K, Schumann G, Banaschewski T, Marquand A, Walter H, Ogoh G, Stahl BC, Brandlistuen R, Schikowski T, Young AH, Xinyang Y, Zhang Z, Agunbiade K, Chen D, Desrivières S, Clinton N, Thompson P, Köhler V, Schwalber A, Calhoun VD, Chang X, Zhang Y, Li Y, Dai Y, Yuan J, Xia Y, Jia T, Renner P, Hese S, Spanlang B, Pearmund C, Athanasiadis AP, Petkoski S, Jirsa V, Schmitt K, Wilbertz JH, Patraskaki M, Sommer P, Heilmann-Heimbach S, Mathey CM, Miller AJ, Claus I, Nöthen MM, Hoffmann P, Forstner AJ, Pastor A, Gallego J, Itatani R, Eiroa-Orosa F, Feixas G, Slater M, Novarino G, Böttger SJ, Tschorn M, Rapp M, Ask H, Kjelkenes R, Fernandez S, Van Der Meer D, Westlye LT, Andreassen OA, Aden R, Seefried B, Nees F, Neidhart M, Stringaris A, Schwarz E, Holz N, Tost H, Meyer-Lindenberg A, Christmann N, Janson K, Schepanski K, Schütz T, Taron UH, Eils R, Roy JC, Lett TA, Kebir H, Polemiti E, Hitchen E, Jentsch M, Serin E, Bernas A, Vaidya N, Twardziok S, Ralser M, Heinz A, Schumann G. 2025. Generating synthetic task-based brain fingerprints for population neuroscience using deep learning. Communications Biology. 8, 1572. mla: Serin, Emin, et al. “Generating Synthetic Task-Based Brain Fingerprints for Population Neuroscience Using Deep Learning.” Communications Biology, vol. 8, 1572, Springer Nature, 2025, doi:10.1038/s42003-025-09158-6. short: E. Serin, K. Ritter, G. Schumann, T. Banaschewski, A. Marquand, H. Walter, G. Ogoh, B.C. Stahl, R. Brandlistuen, T. Schikowski, A.H. Young, Y. Xinyang, Z. Zhang, K. Agunbiade, D. Chen, S. Desrivières, N. Clinton, P. Thompson, V. Köhler, A. Schwalber, V.D. Calhoun, X. Chang, Y. Zhang, Y. Li, Y. Dai, J. Yuan, Y. Xia, T. Jia, P. Renner, S. Hese, B. Spanlang, C. Pearmund, A.P. Athanasiadis, S. Petkoski, V. Jirsa, K. Schmitt, J.H. Wilbertz, M. Patraskaki, P. Sommer, S. Heilmann-Heimbach, C.M. Mathey, A.J. Miller, I. Claus, M.M. Nöthen, P. Hoffmann, A.J. Forstner, A. Pastor, J. Gallego, R. Itatani, F. Eiroa-Orosa, G. Feixas, M. Slater, G. Novarino, S.J. Böttger, M. Tschorn, M. Rapp, H. Ask, R. Kjelkenes, S. Fernandez, D. Van Der Meer, L.T. Westlye, O.A. Andreassen, R. Aden, B. Seefried, F. Nees, M. Neidhart, A. Stringaris, E. Schwarz, N. Holz, H. Tost, A. Meyer-Lindenberg, N. Christmann, K. Janson, K. Schepanski, T. Schütz, U.H. Taron, R. Eils, J.C. Roy, T.A. Lett, H. Kebir, E. Polemiti, E. Hitchen, M. Jentsch, E. Serin, A. Bernas, N. Vaidya, S. Twardziok, M. Ralser, A. Heinz, G. Schumann, Communications Biology 8 (2025). date_created: 2025-11-23T23:01:38Z date_published: 2025-12-01T00:00:00Z date_updated: 2025-12-01T15:24:07Z day: '01' ddc: - '570' department: - _id: GaNo doi: 10.1038/s42003-025-09158-6 external_id: isi: - '001614464000001' pmid: - '41238730' file: - access_level: open_access checksum: b8b3c1abe7048a09b920082a37e786a5 content_type: application/pdf creator: dernst date_created: 2025-11-24T09:12:19Z date_updated: 2025-11-24T09:12:19Z file_id: '20675' file_name: 2025_CommunicationsBiology_Serin.pdf file_size: 1588155 relation: main_file success: 1 file_date_updated: 2025-11-24T09:12:19Z has_accepted_license: '1' intvolume: ' 8' isi: 1 language: - iso: eng month: '12' oa: 1 oa_version: Published Version pmid: 1 publication: Communications Biology publication_identifier: eissn: - 2399-3642 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: Generating synthetic task-based brain fingerprints for population neuroscience using deep learning tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 8 year: '2025' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '20663' abstract: - lang: eng text: Gravitropism, the patterning of postembryonic growth in relation to the gravity vector, allows plants to optimize the use of limited and nonhomogenous resources in their immediate environment. Since the current model of root gravitropism has not been able to integrate all aspects of the response (perception, response, and behavior), research on gravitropism has been dominated by different theories attempting to conceptualize each aspect individually. In this work, we sought to reevaluate all the main components of the root graviresponse through the lens of angle dependence. We show angle dependence in Cholodny–Went-based auxin asymmetry and growth response, which we tracked back to angle-dependent variation in PIN asymmetry and statolith sedimentation in the columella. Thanks to this approach, we were able to suggest distinct roles for PINs and columella cell tiers, and a potential function for auxin vertical flux through the columella. Our findings provide a unifying framework to further explore the mechanisms that regulate angle-dependent gravitropic response, with major implications of time-dependent features of root graviresponse. acknowledgement: This study was funded by the BBSRC (grant no. BB/N010124/1) and Leverhulme Foundation (grant no. RPG-2018-137) to M.D.B. and S.K., a Fully Funded International Research Scholarship awarded to K.S.-F., and by NASA (grant no. 80NSSC21K0585) to C.W. article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Suruchi full_name: Roychoudhry, Suruchi last_name: Roychoudhry - first_name: Katelyn full_name: Sageman-Furnas, Katelyn last_name: Sageman-Furnas - first_name: Harry J. full_name: Taylor, Harry J. last_name: Taylor - first_name: Iftekhar full_name: Showpnil, Iftekhar last_name: Showpnil - first_name: Chris full_name: Wolverton, Chris last_name: Wolverton - first_name: Jiří full_name: Friml, Jiří id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 - first_name: Marta Del full_name: Bianco, Marta Del last_name: Bianco - first_name: Stefan full_name: Kepinski, Stefan last_name: Kepinski citation: ama: Roychoudhry S, Sageman-Furnas K, Taylor HJ, et al. Angle dependence as a unifying feature of root graviresponse modules. Proceedings of the National Academy of Sciences. 2025;122(46):e2506400122. doi:10.1073/pnas.2506400122 apa: Roychoudhry, S., Sageman-Furnas, K., Taylor, H. J., Showpnil, I., Wolverton, C., Friml, J., … Kepinski, S. (2025). Angle dependence as a unifying feature of root graviresponse modules. Proceedings of the National Academy of Sciences. National Academy of Sciences. https://doi.org/10.1073/pnas.2506400122 chicago: Roychoudhry, Suruchi, Katelyn Sageman-Furnas, Harry J. Taylor, Iftekhar Showpnil, Chris Wolverton, Jiří Friml, Marta Del Bianco, and Stefan Kepinski. “Angle Dependence as a Unifying Feature of Root Graviresponse Modules.” Proceedings of the National Academy of Sciences. National Academy of Sciences, 2025. https://doi.org/10.1073/pnas.2506400122. ieee: S. Roychoudhry et al., “Angle dependence as a unifying feature of root graviresponse modules,” Proceedings of the National Academy of Sciences, vol. 122, no. 46. National Academy of Sciences, p. e2506400122, 2025. ista: Roychoudhry S, Sageman-Furnas K, Taylor HJ, Showpnil I, Wolverton C, Friml J, Bianco MD, Kepinski S. 2025. Angle dependence as a unifying feature of root graviresponse modules. Proceedings of the National Academy of Sciences. 122(46), e2506400122. mla: Roychoudhry, Suruchi, et al. “Angle Dependence as a Unifying Feature of Root Graviresponse Modules.” Proceedings of the National Academy of Sciences, vol. 122, no. 46, National Academy of Sciences, 2025, p. e2506400122, doi:10.1073/pnas.2506400122. short: S. Roychoudhry, K. Sageman-Furnas, H.J. Taylor, I. Showpnil, C. Wolverton, J. Friml, M.D. Bianco, S. Kepinski, Proceedings of the National Academy of Sciences 122 (2025) e2506400122. date_created: 2025-11-23T23:01:38Z date_published: 2025-11-18T00:00:00Z date_updated: 2026-02-16T12:31:31Z day: '18' ddc: - '580' department: - _id: JiFr doi: 10.1073/pnas.2506400122 external_id: pmid: - '41218119' file: - access_level: open_access checksum: 5e1c37dddc5db8fbd0128db4a54c4f6b content_type: application/pdf creator: dernst date_created: 2025-11-24T09:48:44Z date_updated: 2025-11-24T09:48:44Z file_id: '20676' file_name: 2025_PNAS_Roychoudhry.pdf file_size: 1394055 relation: main_file success: 1 file_date_updated: 2025-11-24T09:48:44Z has_accepted_license: '1' intvolume: ' 122' issue: '46' language: - iso: eng month: '11' oa: 1 oa_version: Published Version page: e2506400122 pmid: 1 publication: Proceedings of the National Academy of Sciences publication_identifier: eissn: - 1091-6490 publication_status: published publisher: National Academy of Sciences quality_controlled: '1' scopus_import: '1' status: public title: Angle dependence as a unifying feature of root graviresponse modules tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 122 year: '2025' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: diamond PlanS_conform: '1' _id: '20666' abstract: - lang: eng text: We theoretically investigate the stationary properties of a spin-1/2 impurity immersed in a one-dimensional confined Bose gas. In particular, we consider coherently coupled spin states with an external field, where only one spin component interacts with the bath, enabling light dressing of the impurity and spin-dependent bath-impurity interactions. Through detailed comparisons with ab-initio many-body simulations, we demonstrate that the composite system is accurately described by a simplified effective Hamiltonian. The latter builds upon previously developed effective potential approaches in the absence of light dressing. It can be used to extract the impurity energy, residue, effective mass, and anharmonicity induced by the phononic dressing. Light-dressing is shown to increase the polaron residue, undressing the impurity from phononic excitations because of strong spin coupling. For strong repulsions, previously shown to trigger dynamical Bose polaron decay (a phenomenon called temporal orthogonality catastrophe), it is explained that strong light-dressing stabilizes a repulsive polaron-dressed state. Our results establish the effective Hamiltonian framework as a powerful tool for exploring strongly interacting polaronic systems and corroborating forthcoming experimental realizations. acknowledgement: "G.M.K. has received funding by the Austrian Science Fund (FWF)\r\n[DOI: 10.55776/F1004]. S.I.M acknowledges support from the Missouri University of Science and Technology, Department of Physics, Startup fund. F.G. acknowledges funding by the\r\nDeutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC-2111 — 390814868. H.R.S. acknowledges support for ITAMP by the\r\nNSF. P.S. acknowledges funding by the Cluster of Excellence “Advanced Imaging of Matter” of\r\nthe Deutsche Forschungsgemeinschaft (DFG) - EXC 2056 - project ID 390715994." article_number: '093' article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Georgios full_name: Koutentakis, Georgios id: d7b23d3a-9e21-11ec-b482-f76739596b95 last_name: Koutentakis - first_name: S. I. full_name: Mistakidis, S. I. last_name: Mistakidis - first_name: F. full_name: Grusdt, F. last_name: Grusdt - first_name: H. R. full_name: Sadeghpour, H. R. last_name: Sadeghpour - first_name: P. full_name: Schmelcher, P. last_name: Schmelcher citation: ama: Koutentakis G, Mistakidis SI, Grusdt F, Sadeghpour HR, Schmelcher P. Competition of light-and phonon-dressing in microwave-dressed Bose polarons. Scipost Physics. 2025;19(4). doi:10.21468/SciPostPhys.19.4.093 apa: Koutentakis, G., Mistakidis, S. I., Grusdt, F., Sadeghpour, H. R., & Schmelcher, P. (2025). Competition of light-and phonon-dressing in microwave-dressed Bose polarons. Scipost Physics. SciPost Foundation. https://doi.org/10.21468/SciPostPhys.19.4.093 chicago: Koutentakis, Georgios, S. I. Mistakidis, F. Grusdt, H. R. Sadeghpour, and P. Schmelcher. “Competition of Light-and Phonon-Dressing in Microwave-Dressed Bose Polarons.” Scipost Physics. SciPost Foundation, 2025. https://doi.org/10.21468/SciPostPhys.19.4.093. ieee: G. Koutentakis, S. I. Mistakidis, F. Grusdt, H. R. Sadeghpour, and P. Schmelcher, “Competition of light-and phonon-dressing in microwave-dressed Bose polarons,” Scipost Physics, vol. 19, no. 4. SciPost Foundation, 2025. ista: Koutentakis G, Mistakidis SI, Grusdt F, Sadeghpour HR, Schmelcher P. 2025. Competition of light-and phonon-dressing in microwave-dressed Bose polarons. Scipost Physics. 19(4), 093. mla: Koutentakis, Georgios, et al. “Competition of Light-and Phonon-Dressing in Microwave-Dressed Bose Polarons.” Scipost Physics, vol. 19, no. 4, 093, SciPost Foundation, 2025, doi:10.21468/SciPostPhys.19.4.093. short: G. Koutentakis, S.I. Mistakidis, F. Grusdt, H.R. Sadeghpour, P. Schmelcher, Scipost Physics 19 (2025). corr_author: '1' date_created: 2025-11-23T23:01:39Z date_published: 2025-10-01T00:00:00Z date_updated: 2025-12-01T15:22:01Z day: '01' ddc: - '530' department: - _id: MiLe doi: 10.21468/SciPostPhys.19.4.093 external_id: arxiv: - '2504.03411' isi: - '001593017800002' file: - access_level: open_access checksum: 04d0e47ba66c63737431d7b8ed1df4bc content_type: application/pdf creator: dernst date_created: 2025-11-24T08:42:42Z date_updated: 2025-11-24T08:42:42Z file_id: '20673' file_name: 2025_SciPostPhys_Koutentakis.pdf file_size: 1725787 relation: main_file success: 1 file_date_updated: 2025-11-24T08:42:42Z has_accepted_license: '1' intvolume: ' 19' isi: 1 issue: '4' language: - iso: eng month: '10' oa: 1 oa_version: Published Version project: - _id: 7c040762-9f16-11ee-852c-dd79eeee4ab3 grant_number: F100403 name: Coherent Optical Metrology Beyond Electric-Dipole-Allowed Transitions publication: Scipost Physics publication_identifier: eissn: - 2542-4653 publication_status: published publisher: SciPost Foundation quality_controlled: '1' scopus_import: '1' status: public title: Competition of light-and phonon-dressing in microwave-dressed Bose polarons tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 19 year: '2025' ... --- OA_type: closed access _id: '20667' abstract: - lang: eng text: We explore the problem of mean estimation for a high-dimensional binary symmetric Gaussian mixture model, where the label (sign) follows a time-inhomogeneous Markov chain. We propose a spectral estimator based on a partition of a subset of the samples to blocks. We develop a computationally efficient algorithm to find the optimal blocks, and derive minimax lower bounds on the estimation loss of any estimator, which establish the effectiveness of our proposed estimator. The resulting minimax rate illuminates the interplay between the sample size, dimension, signal strength, and the memory on the loss. acknowledgement: The research of A.K. and N.W. was supported by the Israel Science Foundation (ISF), grant no. 1782/22. article_processing_charge: No author: - first_name: Abd full_name: El Latif Kadry, Abd last_name: El Latif Kadry - first_name: Yihan full_name: Zhang, Yihan id: 2ce5da42-b2ea-11eb-bba5-9f264e9d002c last_name: Zhang orcid: 0000-0002-6465-6258 - first_name: Nir full_name: Weinberger, Nir last_name: Weinberger citation: ama: 'El Latif Kadry A, Zhang Y, Weinberger N. Mean estimation in high-dimensional binary timeinhomogeneous Markov Gaussian mixture models. In: 2025 IEEE International Symposium on Information Theory Proceedings. IEEE; 2025. doi:10.1109/ISIT63088.2025.11195426' apa: 'El Latif Kadry, A., Zhang, Y., & Weinberger, N. (2025). Mean estimation in high-dimensional binary timeinhomogeneous Markov Gaussian mixture models. In 2025 IEEE International Symposium on Information Theory Proceedings. Ann Arbor, MI, United States: IEEE. https://doi.org/10.1109/ISIT63088.2025.11195426' chicago: El Latif Kadry, Abd, Yihan Zhang, and Nir Weinberger. “Mean Estimation in High-Dimensional Binary Timeinhomogeneous Markov Gaussian Mixture Models.” In 2025 IEEE International Symposium on Information Theory Proceedings. IEEE, 2025. https://doi.org/10.1109/ISIT63088.2025.11195426. ieee: A. El Latif Kadry, Y. Zhang, and N. Weinberger, “Mean estimation in high-dimensional binary timeinhomogeneous Markov Gaussian mixture models,” in 2025 IEEE International Symposium on Information Theory Proceedings, Ann Arbor, MI, United States, 2025. ista: 'El Latif Kadry A, Zhang Y, Weinberger N. 2025. Mean estimation in high-dimensional binary timeinhomogeneous Markov Gaussian mixture models. 2025 IEEE International Symposium on Information Theory Proceedings. ISIT: International Symposium on Information Theory.' mla: El Latif Kadry, Abd, et al. “Mean Estimation in High-Dimensional Binary Timeinhomogeneous Markov Gaussian Mixture Models.” 2025 IEEE International Symposium on Information Theory Proceedings, IEEE, 2025, doi:10.1109/ISIT63088.2025.11195426. short: A. El Latif Kadry, Y. Zhang, N. Weinberger, in:, 2025 IEEE International Symposium on Information Theory Proceedings, IEEE, 2025. conference: end_date: 2025-06-27 location: Ann Arbor, MI, United States name: 'ISIT: International Symposium on Information Theory' start_date: 2025-06-22 date_created: 2025-11-23T23:01:39Z date_published: 2025-10-20T00:00:00Z date_updated: 2025-11-24T08:53:34Z day: '20' department: - _id: MaMo doi: 10.1109/ISIT63088.2025.11195426 language: - iso: eng month: '10' oa_version: None publication: 2025 IEEE International Symposium on Information Theory Proceedings publication_identifier: isbn: - '9798331543990' issn: - 2157-8095 publication_status: published publisher: IEEE quality_controlled: '1' scopus_import: '1' status: public title: Mean estimation in high-dimensional binary timeinhomogeneous Markov Gaussian mixture models type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2025' ... --- OA_place: publisher OA_type: diamond _id: '20668' abstract: - lang: eng text: "The Message Layer Security (MLS) protocol has recently been standardized by the IETF. MLS is a scalable secure group messaging protocol expected to run more efficiently compared to the Signal protocol at scale, while offering a similar level of strong security. Even though MLS has undergone extensive examination by researchers, the majority of the works have focused on confidentiality.\r\n\r\nIn this work, we focus on the authenticity of the application messages exchanged in MLS. Currently, MLS authenticates every application message with an EdDSA signature and while manageable, the overhead is greatly amplified in the post-quantum setting as the NIST-recommended Dilithium signature results in a 40x increase in size. We view this as an invitation to explore new authentication modes that can be used instead. We start by taking a systematic view on how application messages are authenticated in MLS and categorize authenticity into four different security notions. We then propose several authentication modes, offering a range of different efficiency and security profiles. For instance, in one of our modes, COSMOS++, we replace signatures with one-time tokens and a MAC tag, offering roughly a 75x savings in the post-quantum communication overhead. While this comes at the cost of weakening security compared to the authentication mode used by MLS, the lower communication overhead seems to make it a worthwhile trade-off with security." acknowledgement: This research was partially supported by JST CREST JPMJCR22M1, Japan and funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No.665385. article_processing_charge: No author: - first_name: Keitaro full_name: Hashimoto, Keitaro last_name: Hashimoto - first_name: Shuichi full_name: Katsumata, Shuichi last_name: Katsumata - first_name: Guillermo full_name: Pascual Perez, Guillermo id: 2D7ABD02-F248-11E8-B48F-1D18A9856A87 last_name: Pascual Perez orcid: 0000-0001-8630-415X citation: ama: 'Hashimoto K, Katsumata S, Pascual Perez G. Exploring how to authenticate application messages in MLS: More efficient, post-quantum, and anonymous blocklistable. In: 34th Usenix Security Symposium. Usenix Association; 2025:6699-6716.' apa: 'Hashimoto, K., Katsumata, S., & Pascual Perez, G. (2025). Exploring how to authenticate application messages in MLS: More efficient, post-quantum, and anonymous blocklistable. In 34th Usenix Security Symposium (pp. 6699–6716). Seattle, WA, USA: Usenix Association.' chicago: 'Hashimoto, Keitaro, Shuichi Katsumata, and Guillermo Pascual Perez. “Exploring How to Authenticate Application Messages in MLS: More Efficient, Post-Quantum, and Anonymous Blocklistable.” In 34th Usenix Security Symposium, 6699–6716. Usenix Association, 2025.' ieee: 'K. Hashimoto, S. Katsumata, and G. Pascual Perez, “Exploring how to authenticate application messages in MLS: More efficient, post-quantum, and anonymous blocklistable,” in 34th Usenix Security Symposium, Seattle, WA, USA, 2025, pp. 6699–6716.' ista: 'Hashimoto K, Katsumata S, Pascual Perez G. 2025. Exploring how to authenticate application messages in MLS: More efficient, post-quantum, and anonymous blocklistable. 34th Usenix Security Symposium. USENIX: Security Symposium, 6699–6716.' mla: 'Hashimoto, Keitaro, et al. “Exploring How to Authenticate Application Messages in MLS: More Efficient, Post-Quantum, and Anonymous Blocklistable.” 34th Usenix Security Symposium, Usenix Association, 2025, pp. 6699–716.' short: K. Hashimoto, S. Katsumata, G. Pascual Perez, in:, 34th Usenix Security Symposium, Usenix Association, 2025, pp. 6699–6716. conference: end_date: 2025-08-15 location: Seattle, WA, USA name: 'USENIX: Security Symposium' start_date: 2025-08-13 corr_author: '1' date_created: 2025-11-23T23:01:40Z date_published: 2025-01-01T00:00:00Z date_updated: 2025-11-24T07:46:46Z day: '01' ddc: - '000' ec_funded: 1 file: - access_level: open_access checksum: fcfe8851aeb751af98c0b1335a0ef149 content_type: application/pdf creator: dernst date_created: 2025-11-24T07:44:08Z date_updated: 2025-11-24T07:44:08Z file_id: '20671' file_name: 2025_Usenix_Hashimoto.pdf file_size: 710733 relation: main_file success: 1 file_date_updated: 2025-11-24T07:44:08Z has_accepted_license: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://eprint.iacr.org/2025/426 month: '01' oa: 1 oa_version: Published Version page: 6699-6716 project: - _id: 2564DBCA-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '665385' name: International IST Doctoral Program publication: 34th Usenix Security Symposium publication_identifier: isbn: - '9781939133526' publication_status: published publisher: Usenix Association quality_controlled: '1' scopus_import: '1' status: public title: 'Exploring how to authenticate application messages in MLS: More efficient, post-quantum, and anonymous blocklistable' type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2025' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '20669' abstract: - lang: eng text: 'Ice cliffs and supraglacial ponds are key drivers of mass loss on debris-covered glaciers. However, the relationship between melt ponds and adjacent ice cliffs has not been fully explored. We investigated the seasonal drainage patterns of a melt pond on the debris-covered Zhuxi Glacier in southeast Tibet and estimated the mass loss of its adjacent ice cliff during 2023-2024. Using hourly time-lapse photogrammetry we built a series of high-resolution point clouds to quantify the evolution of the ice cliff-pond system. Our findings indicate that subaerial melting and undercutting were the primary mechanisms of ice cliff mass loss during summer. In winter when the pond water level dropped, ice cliff calving became the dominant mode of ice loss. As the water level rose in spring, calving and subaerial melting occurred simultaneously and ice loss from calving accounted for approximately 19.5 % of total ice loss from February to July 2024. Our results reveal the transitional state of this ice cliff-pond system, exhibiting characteristics of both melt hotspots and lake-terminating calving fronts, and highlight the interplay between seasonal drainage-refill pond and differing modes of ice loss on adjacent ice cliff. Future research should focus on additional high-resolution monitoring of similar systems and incorporation of ice cliff-pond dynamics in glacier-scale numerical models. ' acknowledgement: This study was supported by the National Natural Science Foundation of China (grant nos. 42271138, 42201144), Lhasa Science and Technology Plan Project (LSKJ202406), the National Key R&D Program of China (grant nos. 2024YFF0808601), and the Science and Technology Plan Projects of Tibet Autonomous Region (Grants XZ202501ZY0081 and XZ202401ZY0003). ZH additionally acknowledges mobility funding provided by China Scholarship Council (CSC), supporting an extended research stay at the University of Plymouth, where much of this research was completed. article_processing_charge: Yes article_type: original author: - first_name: Zhen full_name: He, Zhen last_name: He - first_name: Matthew full_name: Westoby, Matthew last_name: Westoby - first_name: Shaoting full_name: Ren, Shaoting id: 2066b6dd-2d54-11ef-8f8c-c94731161817 last_name: Ren - first_name: Chuanxi full_name: Zhao, Chuanxi last_name: Zhao - first_name: Yifei full_name: He, Yifei last_name: He - first_name: Tianzhao full_name: Zhang, Tianzhao last_name: Zhang - first_name: Wei full_name: Yang, Wei last_name: Yang citation: ama: He Z, Westoby M, REN S, et al. Quantifying the seasonal dynamics of a transitional ice cliff-pond system on a debris-covered glacier. Journal of Glaciology. 2025. doi:10.1017/jog.2025.10104 apa: He, Z., Westoby, M., REN, S., Zhao, C., He, Y., Zhang, T., & Yang, W. (2025). Quantifying the seasonal dynamics of a transitional ice cliff-pond system on a debris-covered glacier. Journal of Glaciology. Cambridge University Press. https://doi.org/10.1017/jog.2025.10104 chicago: He, Zhen, Matthew Westoby, SHAOTING REN, Chuanxi Zhao, Yifei He, Tianzhao Zhang, and Wei Yang. “Quantifying the Seasonal Dynamics of a Transitional Ice Cliff-Pond System on a Debris-Covered Glacier.” Journal of Glaciology. Cambridge University Press, 2025. https://doi.org/10.1017/jog.2025.10104. ieee: Z. He et al., “Quantifying the seasonal dynamics of a transitional ice cliff-pond system on a debris-covered glacier,” Journal of Glaciology. Cambridge University Press, 2025. ista: He Z, Westoby M, REN S, Zhao C, He Y, Zhang T, Yang W. 2025. Quantifying the seasonal dynamics of a transitional ice cliff-pond system on a debris-covered glacier. Journal of Glaciology. mla: He, Zhen, et al. “Quantifying the Seasonal Dynamics of a Transitional Ice Cliff-Pond System on a Debris-Covered Glacier.” Journal of Glaciology, Cambridge University Press, 2025, doi:10.1017/jog.2025.10104. short: Z. He, M. Westoby, S. REN, C. Zhao, Y. He, T. Zhang, W. Yang, Journal of Glaciology (2025). date_created: 2025-11-23T23:01:40Z date_published: 2025-11-10T00:00:00Z date_updated: 2025-11-24T07:59:14Z day: '10' department: - _id: FrPe doi: 10.1017/jog.2025.10104 language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1017/jog.2025.10104 month: '11' oa: 1 oa_version: Published Version publication: Journal of Glaciology publication_identifier: eissn: - 1727-5652 issn: - 0022-1430 publication_status: epub_ahead publisher: Cambridge University Press quality_controlled: '1' scopus_import: '1' status: public title: Quantifying the seasonal dynamics of a transitional ice cliff-pond system on a debris-covered glacier type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2025' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '20670' abstract: - lang: eng text: 'β-Barrel nanopores are involved in crucial biological processes, from ATP export in mitochondria to bacterial resistance, and represent a promising platform for emerging sequencing technologies. However, in contrast to ion channels, the understanding of the fundamental principles governing ion transport through these nanopores remains largely unexplored. Here we integrate experimental, numerical and theoretical approaches to elucidate ion transport mechanisms in β-barrel nanopores. We identify and characterize two distinct nonlinear phenomena: open-pore rectification and gating. Through extensive mutation analysis of aerolysin nanopores, we demonstrate that open-pore rectification is caused by ionic accumulation driven by the distribution of lumen charges. In addition, we provide converging evidence suggesting that gating is controlled by electric fields dissociating counterions from lumen charges, promoting local structural deformations. Our findings establish a rigorous framework for characterizing and understanding ion transport processes in protein-based nanopores, enabling the design of adaptable nanofluidic biotechnologies. We illustrate this by optimizing an aerolysin mutant for computing applications.' acknowledgement: We are grateful to M. Mayer and G. van der Goot for their insightful discussions and thoughtful feedback. We acknowledge funding from the European Research Council (grants 101020445—2D-LIQUID N.R. and A.R., MSCA number 101034413 P.R.), the Swiss National Science Foundation (grants 205321_192371 and 200021L_212128 to M.D.P., TMPFP2-217134 to T.E., and IZSEZ0_183779 to J.H.G. and A.R.) and the Swiss National Supercomputing Centre (CSCS) for access to the HPC resources used to run MD simulations. We thank the staff members of the Dubochet Center for Imaging in Lausanne, in particular E. Uchikawa and S. Nazarov, for their assistance with cryo-EM sample preparation and data collection. We thank A. Antanasijevic and Y. Duhoo from EPFL Protein Production and Structure Core Facility for their support in cryo-EM data processing. article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Simon full_name: Mayer, Simon last_name: Mayer - first_name: Marianna Fanouria full_name: Mitsioni, Marianna Fanouria last_name: Mitsioni - first_name: Paul full_name: Robin, Paul id: 48c58128-57b0-11ee-9095-dc28fd97fc1d last_name: Robin orcid: 0000-0002-5728-9189 - first_name: Lukas full_name: Van Den Heuvel, Lukas last_name: Van Den Heuvel - first_name: Nathan full_name: Ronceray, Nathan last_name: Ronceray - first_name: Maria Jose full_name: Marcaida, Maria Jose last_name: Marcaida - first_name: Luciano A. full_name: Abriata, Luciano A. last_name: Abriata - first_name: Lucien F. full_name: Krapp, Lucien F. last_name: Krapp - first_name: Jana S. full_name: Anton, Jana S. last_name: Anton - first_name: Sarah full_name: Soussou, Sarah last_name: Soussou - first_name: Justin full_name: Jeanneret-Grosjean, Justin last_name: Jeanneret-Grosjean - first_name: Alessandro full_name: Fulciniti, Alessandro last_name: Fulciniti - first_name: Alexia full_name: Möller, Alexia last_name: Möller - first_name: Sarah full_name: Vacle, Sarah last_name: Vacle - first_name: Lely full_name: Feletti, Lely last_name: Feletti - first_name: Henry full_name: Brinkerhoff, Henry last_name: Brinkerhoff - first_name: Andrew H. full_name: Laszlo, Andrew H. last_name: Laszlo - first_name: Jens H. full_name: Gundlach, Jens H. last_name: Gundlach - first_name: Theo full_name: Emmerich, Theo last_name: Emmerich - first_name: Matteo full_name: Dal Peraro, Matteo last_name: Dal Peraro - first_name: Aleksandra full_name: Radenovic, Aleksandra last_name: Radenovic citation: ama: Mayer S, Mitsioni MF, Robin P, et al. Lumen charge governs gated ion transport in β-barrel nanopores. Nature Nanotechnology. 2025. doi:10.1038/s41565-025-02052-6 apa: Mayer, S., Mitsioni, M. F., Robin, P., Van Den Heuvel, L., Ronceray, N., Marcaida, M. J., … Radenovic, A. (2025). Lumen charge governs gated ion transport in β-barrel nanopores. Nature Nanotechnology. Springer Nature. https://doi.org/10.1038/s41565-025-02052-6 chicago: Mayer, Simon, Marianna Fanouria Mitsioni, Paul Robin, Lukas Van Den Heuvel, Nathan Ronceray, Maria Jose Marcaida, Luciano A. Abriata, et al. “Lumen Charge Governs Gated Ion Transport in β-Barrel Nanopores.” Nature Nanotechnology. Springer Nature, 2025. https://doi.org/10.1038/s41565-025-02052-6. ieee: S. Mayer et al., “Lumen charge governs gated ion transport in β-barrel nanopores,” Nature Nanotechnology. Springer Nature, 2025. ista: Mayer S, Mitsioni MF, Robin P, Van Den Heuvel L, Ronceray N, Marcaida MJ, Abriata LA, Krapp LF, Anton JS, Soussou S, Jeanneret-Grosjean J, Fulciniti A, Möller A, Vacle S, Feletti L, Brinkerhoff H, Laszlo AH, Gundlach JH, Emmerich T, Dal Peraro M, Radenovic A. 2025. Lumen charge governs gated ion transport in β-barrel nanopores. Nature Nanotechnology. mla: Mayer, Simon, et al. “Lumen Charge Governs Gated Ion Transport in β-Barrel Nanopores.” Nature Nanotechnology, Springer Nature, 2025, doi:10.1038/s41565-025-02052-6. short: S. Mayer, M.F. Mitsioni, P. Robin, L. Van Den Heuvel, N. Ronceray, M.J. Marcaida, L.A. Abriata, L.F. Krapp, J.S. Anton, S. Soussou, J. Jeanneret-Grosjean, A. Fulciniti, A. Möller, S. Vacle, L. Feletti, H. Brinkerhoff, A.H. Laszlo, J.H. Gundlach, T. Emmerich, M. Dal Peraro, A. Radenovic, Nature Nanotechnology (2025). date_created: 2025-11-23T23:01:40Z date_published: 2025-11-11T00:00:00Z date_updated: 2025-12-01T15:20:40Z day: '11' department: - _id: EdHa doi: 10.1038/s41565-025-02052-6 external_id: isi: - '001611698900001' pmid: - '41219410' isi: 1 language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1038/s41565-025-02052-6 month: '11' oa: 1 oa_version: Published Version pmid: 1 publication: Nature Nanotechnology publication_identifier: eissn: - 1748-3395 issn: - 1748-3387 publication_status: epub_ahead publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: Lumen charge governs gated ion transport in β-barrel nanopores type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2025' ... --- OA_place: publisher OA_type: gold _id: '20684' abstract: - lang: eng text: "Quantization is a powerful tool for accelerating large language model (LLM) inference, but the accuracy-performance trade-offs across different formats remain unclear. In this paper, we conduct the most comprehensive empirical study to date, evaluating FP8, INT8, and INT4\r\nquantization across academic benchmarks and real-world tasks on the entire Llama-3.1 model\r\nfamily. Through over 500,000 evaluations, our investigation yields several key findings: (1) FP8 (W8A8-FP) is effectively lossless across all model scales, (2) well-tuned INT8 (W8A8-INT) achieves surprisingly low (1-3%) accuracy degradation, and (3) INT4 weightonly (W4A16-INT) is more competitive than expected, rivaling 8-bit quantization. Further, we investigate the optimal quantization format for different deployments by analyzing inference performance through the popular vLLM framework. Our analysis provides clear deployment recommendations: W4A16 is the most cost-efficient for synchronous setups, while W8A8 dominates in asynchronous\r\ncontinuous batching. For mixed workloads, the optimal choice depends on the specific use\r\ncase. Our findings offer practical, data-driven guidelines for deploying quantized LLMs at scale—ensuring the best balance between speed, efficiency, and accuracy. " article_processing_charge: No arxiv: 1 author: - first_name: Eldar full_name: Kurtic, Eldar id: 47beb3a5-07b5-11eb-9b87-b108ec578218 last_name: Kurtic - first_name: Alexandre full_name: Marques, Alexandre last_name: Marques - first_name: Shubhra full_name: Pandit, Shubhra last_name: Pandit - first_name: Mark full_name: Kurtz, Mark last_name: Kurtz - first_name: Dan-Adrian full_name: Alistarh, Dan-Adrian id: 4A899BFC-F248-11E8-B48F-1D18A9856A87 last_name: Alistarh orcid: 0000-0003-3650-940X citation: ama: 'Kurtic E, Marques A, Pandit S, Kurtz M, Alistarh D-A. “Give me BF16 or give me death”? Accuracy-performance trade-offs in LLM quantization. In: Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics. Association for Computational Linguistics; 2025:26872-26886.' apa: 'Kurtic, E., Marques, A., Pandit, S., Kurtz, M., & Alistarh, D.-A. (2025). “Give me BF16 or give me death”? Accuracy-performance trade-offs in LLM quantization. In Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics (pp. 26872–26886). Vienna, Austria: Association for Computational Linguistics.' chicago: Kurtic, Eldar, Alexandre Marques, Shubhra Pandit, Mark Kurtz, and Dan-Adrian Alistarh. “‘Give Me BF16 or Give Me Death’? Accuracy-Performance Trade-Offs in LLM Quantization.” In Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics, 26872–86. Association for Computational Linguistics, 2025. ieee: E. Kurtic, A. Marques, S. Pandit, M. Kurtz, and D.-A. Alistarh, “‘Give me BF16 or give me death’? Accuracy-performance trade-offs in LLM quantization,” in Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics, Vienna, Austria, 2025, pp. 26872–26886. ista: 'Kurtic E, Marques A, Pandit S, Kurtz M, Alistarh D-A. 2025. “Give me BF16 or give me death”? Accuracy-performance trade-offs in LLM quantization. Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics. ACL: Meeting of the Association for Computational Linguistics, 26872–26886.' mla: Kurtic, Eldar, et al. “‘Give Me BF16 or Give Me Death’? Accuracy-Performance Trade-Offs in LLM Quantization.” Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics, Association for Computational Linguistics, 2025, pp. 26872–86. short: E. Kurtic, A. Marques, S. Pandit, M. Kurtz, D.-A. Alistarh, in:, Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics, Association for Computational Linguistics, 2025, pp. 26872–26886. conference: end_date: 2025-08-01 location: Vienna, Austria name: 'ACL: Meeting of the Association for Computational Linguistics' start_date: 2025-07-27 corr_author: '1' date_created: 2025-11-24T14:20:46Z date_published: 2025-08-01T00:00:00Z date_updated: 2025-11-26T11:15:11Z day: '01' ddc: - '000' department: - _id: DaAl external_id: arxiv: - '2411.02355' file: - access_level: open_access checksum: 4c066ee20f9ab17619c95652c0eb75f1 content_type: application/pdf creator: dernst date_created: 2025-11-26T11:06:57Z date_updated: 2025-11-26T11:06:57Z file_id: '20698' file_name: 2025_ACL_Kurtic.pdf file_size: 417450 relation: main_file success: 1 file_date_updated: 2025-11-26T11:06:57Z has_accepted_license: '1' language: - iso: eng month: '08' oa: 1 oa_version: Published Version page: 26872-26886 publication: Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics publication_identifier: isbn: - '9798891762510' issn: - 0736-587X publication_status: published publisher: Association for Computational Linguistics quality_controlled: '1' scopus_import: '1' status: public title: “Give me BF16 or give me death”? Accuracy-performance trade-offs in LLM quantization tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2025' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '20685' abstract: - lang: eng text: 'The Next Generation of Earth Modeling Systems (nextGEMS) project aimed to produce multidecadal climate simulations, for the first time, with resolved kilometer-scale (km-scale) processes in the ocean, land, and atmosphere. In only 3 years, nextGEMS achieved this milestone with the two km-scale Earth system models, ICOsahedral Non-hydrostatic model (ICON) and Integrated Forecasting System coupled to the Finite-volumE Sea ice-Ocean Model (IFS-FESOM). nextGEMS was based on three cornerstones: (1) developing km-scale Earth system models with small errors in the energy and water balance, (2) performing km-scale climate simulations with a throughput greater than 1 simulated year per day, and (3) facilitating new workflows for an efficient analysis of the large simulations with common data structures and output variables. These cornerstones shaped the timeline of nextGEMS, divided into four cycles. Each cycle marked the release of a new configuration of ICON and IFS-FESOM, which were evaluated at hackathons. The hackathon participants included experts from climate science, software engineering, and high-performance computing as well as users from the energy and agricultural sectors. The continuous efforts over the four cycles allowed us to produce 30-year simulations with ICON and IFS-FESOM, spanning the period 2020–2049 under the SSP3-7.0 scenario. The throughput was about 500 simulated days per day on the Levante supercomputer of the German Climate Computing Center (DKRZ). The simulations employed a horizontal grid of about 5 km resolution in the ocean and 10 km resolution in the atmosphere and land. Aside from this technical achievement, the simulations allowed us to gain new insights into the realism of ICON and IFS-FESOM. Beyond its time frame, nextGEMS builds the foundation of the Climate Change Adaptation Digital Twin developed in the Destination Earth initiative and paves the way for future European research on climate change.' acknowledgement: "This research was supported by the Horizon 2020 project nextGEMS under grant agreement no. 101003470. Most simulations were performed and analyzed on facilities of the DKRZ (HLRE-4 Levante, 2024) with resources granted under project bm1235. We would like to thank DKRZ staff for their continued support in running the simulations and hosting and handling the data, in particular Jan Frederik Engels, Hendryk Bockelmann, Fabian Wachsmann, Irina Fast, and Carsten Beyer. We also want to thank the two anonymous reviewers for their insightful comments.This research has been supported by the EU Horizon 2020 (grant no. 101003470).\r\nThe article processing charges for this open-access publication were covered by the Max Planck Society." article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Hans full_name: Segura, Hans last_name: Segura - first_name: Xabier full_name: Pedruzo-Bagazgoitia, Xabier last_name: Pedruzo-Bagazgoitia - first_name: Philipp full_name: Weiss, Philipp last_name: Weiss - first_name: Sebastian K. full_name: Müller, Sebastian K. last_name: Müller - first_name: Thomas full_name: Rackow, Thomas last_name: Rackow - first_name: Junhong full_name: Lee, Junhong last_name: Lee - first_name: Edgar full_name: Dolores-Tesillos, Edgar last_name: Dolores-Tesillos - first_name: Imme full_name: Benedict, Imme last_name: Benedict - first_name: Matthias full_name: Aengenheyster, Matthias last_name: Aengenheyster - first_name: Razvan full_name: Aguridan, Razvan last_name: Aguridan - first_name: Gabriele full_name: Arduini, Gabriele last_name: Arduini - first_name: Alexander J. full_name: Baker, Alexander J. last_name: Baker - first_name: Jiawei full_name: Bao, Jiawei id: bb9a7399-fefd-11ed-be3c-ae648fd1d160 last_name: Bao - first_name: Swantje full_name: Bastin, Swantje last_name: Bastin - first_name: Eulàlia full_name: Baulenas, Eulàlia last_name: Baulenas - first_name: Tobias full_name: Becker, Tobias last_name: Becker - first_name: Sebastian full_name: Beyer, Sebastian last_name: Beyer - first_name: Hendryk full_name: Bockelmann, Hendryk last_name: Bockelmann - first_name: Nils full_name: Brüggemann, Nils last_name: Brüggemann - first_name: Lukas full_name: Brunner, Lukas last_name: Brunner - first_name: Suvarchal K. full_name: Cheedela, Suvarchal K. last_name: Cheedela - first_name: Sushant full_name: Das, Sushant last_name: Das - first_name: Jasper full_name: Denissen, Jasper last_name: Denissen - first_name: Ian full_name: Dragaud, Ian last_name: Dragaud - first_name: Piotr full_name: Dziekan, Piotr last_name: Dziekan - first_name: Madeleine full_name: Ekblom, Madeleine last_name: Ekblom - first_name: Jan Frederik full_name: Engels, Jan Frederik last_name: Engels - first_name: Monika full_name: Esch, Monika last_name: Esch - first_name: Richard full_name: Forbes, Richard last_name: Forbes - first_name: Claudia full_name: Frauen, Claudia last_name: Frauen - first_name: Lilli full_name: Freischem, Lilli last_name: Freischem - first_name: Diego full_name: García-Maroto, Diego last_name: García-Maroto - first_name: Philipp full_name: Geier, Philipp last_name: Geier - first_name: Paul full_name: Gierz, Paul last_name: Gierz - first_name: Álvaro full_name: González-Cervera, Álvaro last_name: González-Cervera - first_name: Katherine full_name: Grayson, Katherine last_name: Grayson - first_name: Matthew full_name: Griffith, Matthew last_name: Griffith - first_name: Oliver full_name: Gutjahr, Oliver last_name: Gutjahr - first_name: Helmuth full_name: Haak, Helmuth last_name: Haak - first_name: Ioan full_name: Hadade, Ioan last_name: Hadade - first_name: Kerstin full_name: Haslehner, Kerstin last_name: Haslehner - first_name: Shabeh full_name: ul Hasson, Shabeh last_name: ul Hasson - first_name: Jan full_name: Hegewald, Jan last_name: Hegewald - first_name: Lukas full_name: Kluft, Lukas last_name: Kluft - first_name: Aleksei full_name: Koldunov, Aleksei last_name: Koldunov - first_name: Nikolay full_name: Koldunov, Nikolay last_name: Koldunov - first_name: Tobias full_name: Kölling, Tobias last_name: Kölling - first_name: Shunya full_name: Koseki, Shunya last_name: Koseki - first_name: Sergey full_name: Kosukhin, Sergey last_name: Kosukhin - first_name: Josh full_name: Kousal, Josh last_name: Kousal - first_name: Peter full_name: Kuma, Peter last_name: Kuma - first_name: Arjun U. full_name: Kumar, Arjun U. last_name: Kumar - first_name: Rumeng full_name: Li, Rumeng last_name: Li - first_name: Nicolas full_name: Maury, Nicolas last_name: Maury - first_name: Maximilian full_name: Meindl, Maximilian last_name: Meindl - first_name: Sebastian full_name: Milinski, Sebastian last_name: Milinski - first_name: Kristian full_name: Mogensen, Kristian last_name: Mogensen - first_name: Bimochan full_name: Niraula, Bimochan last_name: Niraula - first_name: Jakub full_name: Nowak, Jakub last_name: Nowak - first_name: Divya Sri full_name: Praturi, Divya Sri last_name: Praturi - first_name: Ulrike full_name: Proske, Ulrike last_name: Proske - first_name: Dian full_name: Putrasahan, Dian last_name: Putrasahan - first_name: René full_name: Redler, René last_name: Redler - first_name: David full_name: Santuy, David last_name: Santuy - first_name: Domokos full_name: Sármány, Domokos last_name: Sármány - first_name: Reiner full_name: Schnur, Reiner last_name: Schnur - first_name: Patrick full_name: Scholz, Patrick last_name: Scholz - first_name: Dmitry full_name: Sidorenko, Dmitry last_name: Sidorenko - first_name: Dorian full_name: Spät, Dorian last_name: Spät - first_name: Birgit full_name: Sützl, Birgit last_name: Sützl - first_name: Daisuke full_name: Takasuka, Daisuke last_name: Takasuka - first_name: Adrian full_name: Tompkins, Adrian last_name: Tompkins - first_name: Alejandro full_name: Uribe, Alejandro last_name: Uribe - first_name: Mirco full_name: Valentini, Mirco last_name: Valentini - first_name: Menno full_name: Veerman, Menno last_name: Veerman - first_name: Aiko full_name: Voigt, Aiko last_name: Voigt - first_name: Sarah full_name: Warnau, Sarah last_name: Warnau - first_name: Fabian full_name: Wachsmann, Fabian last_name: Wachsmann - first_name: Marta full_name: Wacławczyk, Marta last_name: Wacławczyk - first_name: Nils full_name: Wedi, Nils last_name: Wedi - first_name: Karl-Hermann full_name: Wieners, Karl-Hermann last_name: Wieners - first_name: Jonathan full_name: Wille, Jonathan last_name: Wille - first_name: Marius full_name: Winkler, Marius last_name: Winkler - first_name: Yuting full_name: Wu, Yuting last_name: Wu - first_name: Florian full_name: Ziemen, Florian last_name: Ziemen - first_name: Janos full_name: Zimmermann, Janos last_name: Zimmermann - first_name: Frida A.-M. full_name: Bender, Frida A.-M. last_name: Bender - first_name: Dragana full_name: Bojovic, Dragana last_name: Bojovic - first_name: Sandrine full_name: Bony, Sandrine last_name: Bony - first_name: Simona full_name: Bordoni, Simona last_name: Bordoni - first_name: Patrice full_name: Brehmer, Patrice last_name: Brehmer - first_name: Marcus full_name: Dengler, Marcus last_name: Dengler - first_name: Emanuel full_name: Dutra, Emanuel last_name: Dutra - first_name: Saliou full_name: Faye, Saliou last_name: Faye - first_name: Erich full_name: Fischer, Erich last_name: Fischer - first_name: Chiel full_name: van Heerwaarden, Chiel last_name: van Heerwaarden - first_name: Cathy full_name: Hohenegger, Cathy last_name: Hohenegger - first_name: Heikki full_name: Järvinen, Heikki last_name: Järvinen - first_name: Markus full_name: Jochum, Markus last_name: Jochum - first_name: Thomas full_name: Jung, Thomas last_name: Jung - first_name: Johann H. full_name: Jungclaus, Johann H. last_name: Jungclaus - first_name: Noel S. full_name: Keenlyside, Noel S. last_name: Keenlyside - first_name: Daniel full_name: Klocke, Daniel last_name: Klocke - first_name: Heike full_name: Konow, Heike last_name: Konow - first_name: Martina full_name: Klose, Martina last_name: Klose - first_name: Szymon full_name: Malinowski, Szymon last_name: Malinowski - first_name: Olivia full_name: Martius, Olivia last_name: Martius - first_name: Thorsten full_name: Mauritsen, Thorsten last_name: Mauritsen - first_name: Juan Pedro full_name: Mellado, Juan Pedro last_name: Mellado - first_name: Theresa full_name: Mieslinger, Theresa last_name: Mieslinger - first_name: Elsa full_name: Mohino, Elsa last_name: Mohino - first_name: Hanna full_name: Pawłowska, Hanna last_name: Pawłowska - first_name: Karsten full_name: Peters-von Gehlen, Karsten last_name: Peters-von Gehlen - first_name: Abdoulaye full_name: Sarré, Abdoulaye last_name: Sarré - first_name: Pajam full_name: Sobhani, Pajam last_name: Sobhani - first_name: Philip full_name: Stier, Philip last_name: Stier - first_name: Lauri full_name: Tuppi, Lauri last_name: Tuppi - first_name: Pier Luigi full_name: Vidale, Pier Luigi last_name: Vidale - first_name: Irina full_name: Sandu, Irina last_name: Sandu - first_name: Bjorn full_name: Stevens, Bjorn last_name: Stevens citation: ama: 'Segura H, Pedruzo-Bagazgoitia X, Weiss P, et al. nextGEMS: Entering the era of kilometer-scale Earth system modeling. Geoscientific Model Development. 2025;18(20):7735-7761. doi:10.5194/gmd-18-7735-2025' apa: 'Segura, H., Pedruzo-Bagazgoitia, X., Weiss, P., Müller, S. K., Rackow, T., Lee, J., … Stevens, B. (2025). nextGEMS: Entering the era of kilometer-scale Earth system modeling. Geoscientific Model Development. Copernicus Publications. https://doi.org/10.5194/gmd-18-7735-2025' chicago: 'Segura, Hans, Xabier Pedruzo-Bagazgoitia, Philipp Weiss, Sebastian K. Müller, Thomas Rackow, Junhong Lee, Edgar Dolores-Tesillos, et al. “NextGEMS: Entering the Era of Kilometer-Scale Earth System Modeling.” Geoscientific Model Development. Copernicus Publications, 2025. https://doi.org/10.5194/gmd-18-7735-2025.' ieee: 'H. Segura et al., “nextGEMS: Entering the era of kilometer-scale Earth system modeling,” Geoscientific Model Development, vol. 18, no. 20. Copernicus Publications, pp. 7735–7761, 2025.' ista: 'Segura H et al. 2025. nextGEMS: Entering the era of kilometer-scale Earth system modeling. Geoscientific Model Development. 18(20), 7735–7761.' mla: 'Segura, Hans, et al. “NextGEMS: Entering the Era of Kilometer-Scale Earth System Modeling.” Geoscientific Model Development, vol. 18, no. 20, Copernicus Publications, 2025, pp. 7735–61, doi:10.5194/gmd-18-7735-2025.' short: H. Segura, X. Pedruzo-Bagazgoitia, P. Weiss, S.K. Müller, T. Rackow, J. Lee, E. Dolores-Tesillos, I. Benedict, M. Aengenheyster, R. Aguridan, G. Arduini, A.J. Baker, J. Bao, S. Bastin, E. Baulenas, T. Becker, S. Beyer, H. Bockelmann, N. Brüggemann, L. Brunner, S.K. Cheedela, S. Das, J. Denissen, I. Dragaud, P. Dziekan, M. Ekblom, J.F. Engels, M. Esch, R. Forbes, C. Frauen, L. Freischem, D. García-Maroto, P. Geier, P. Gierz, Á. González-Cervera, K. Grayson, M. Griffith, O. Gutjahr, H. Haak, I. Hadade, K. Haslehner, S. ul Hasson, J. Hegewald, L. Kluft, A. Koldunov, N. Koldunov, T. Kölling, S. Koseki, S. Kosukhin, J. Kousal, P. Kuma, A.U. Kumar, R. Li, N. Maury, M. Meindl, S. Milinski, K. Mogensen, B. Niraula, J. Nowak, D.S. Praturi, U. Proske, D. Putrasahan, R. Redler, D. Santuy, D. Sármány, R. Schnur, P. Scholz, D. Sidorenko, D. Spät, B. Sützl, D. Takasuka, A. Tompkins, A. Uribe, M. Valentini, M. Veerman, A. Voigt, S. Warnau, F. Wachsmann, M. Wacławczyk, N. Wedi, K.-H. Wieners, J. Wille, M. Winkler, Y. Wu, F. Ziemen, J. Zimmermann, F.A.-M. Bender, D. Bojovic, S. Bony, S. Bordoni, P. Brehmer, M. Dengler, E. Dutra, S. Faye, E. Fischer, C. van Heerwaarden, C. Hohenegger, H. Järvinen, M. Jochum, T. Jung, J.H. Jungclaus, N.S. Keenlyside, D. Klocke, H. Konow, M. Klose, S. Malinowski, O. Martius, T. Mauritsen, J.P. Mellado, T. Mieslinger, E. Mohino, H. Pawłowska, K. Peters-von Gehlen, A. Sarré, P. Sobhani, P. Stier, L. Tuppi, P.L. Vidale, I. Sandu, B. Stevens, Geoscientific Model Development 18 (2025) 7735–7761. date_created: 2025-11-24T14:23:07Z date_published: 2025-10-23T00:00:00Z date_updated: 2025-11-25T12:33:05Z day: '23' ddc: - '550' department: - _id: CaMu doi: 10.5194/gmd-18-7735-2025 file: - access_level: open_access checksum: 0f6a4af94e3a6be773d0051256bcecf5 content_type: application/pdf creator: dernst date_created: 2025-11-25T12:02:30Z date_updated: 2025-11-25T12:02:30Z file_id: '20692' file_name: 2025_GeosciModelDev_Segura.pdf file_size: 8618996 relation: main_file success: 1 file_date_updated: 2025-11-25T12:02:30Z has_accepted_license: '1' intvolume: ' 18' issue: '20' language: - iso: eng month: '10' oa: 1 oa_version: Published Version page: 7735-7761 publication: Geoscientific Model Development publication_identifier: eissn: - 1991-9603 publication_status: published publisher: Copernicus Publications quality_controlled: '1' scopus_import: '1' status: public title: 'nextGEMS: Entering the era of kilometer-scale Earth system modeling' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 18 year: '2025' ... --- OA_place: publisher OA_type: diamond PlanS_conform: '1' _id: '20686' abstract: - lang: eng text: Emission from two massive black holes (MBHs) bound in a close binary is expected to be modulated by different processes, such as the Doppler boost due to the orbital motion, accretion rate variability generated by the interaction with a circumbinary disc, and binary gravitational self-lensing. When the binary is compact enough, the two black holes are thought to be surrounded by a common broad-line region that reprocesses the impinging periodically varying ionising flux, creating broad emission lines with variable line shapes. Therefore, the study of broad emission line variability through multi-epoch spectroscopic campaigns is of paramount importance for the unambiguous identification of a binary. In this work, we study the response of a disc-like broad-line region to the Doppler-boosted ionising flux emitted by sub-milliparsec MBH binaries on a circular orbit and compare it with the response of a broad-line region illuminated by a single MBH with a periodically but isotropically varying intrinsic luminosity. We show that in the binary case, the time lags of the blue and red wings of the broad emission lines, arising from diametrically opposite sides of the circumbinary disc, are out of phase by half of the binary’s orbital period, as they each respond to the periodic ‘lighthouse’ modulation from the binary’s continuum emission. This asymmetric time lag represents a new binary signature that cannot be mimicked by a single MBH. acknowledgement: MD acknowledge funding from MIUR under the grant PRIN 2017-MB8AEZ, and financial support from ICSC – Centro Nazionale di Ricerca in High Performance Computing, Big Data and Quantum Computing, funded by European Union – NextGenerationEU. This study is supported by the Italian Ministry for Research and University (MUR) under Grant ‘Progetto Dipartimenti di Eccellenza 2023-2027’ (BiCoQ). FR acknowledges the support from the Next Generation EU funds within the National Recovery and Resilience Plan (PNRR), Mission 4 – Education and Research, Component 2 – From Research to Business (M4C2), Investment Line 3.1 – Strengthening and creation of Research Infrastructures, Project IR0000012 – CTA+ – Cherenkov Telescope Array Plus. DJD acknowledges support from the Danish Independent Research Fund through Sapere Aude Starting Grant No. 121587 ZH acknowledges support from NSF grant AST-2006176 and NASA grants 80NSSC22K0822 and 80NSSC24K0440. article_number: A165 article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Lorenzo full_name: Bertassi, Lorenzo last_name: Bertassi - first_name: Erika full_name: Sottocorno, Erika last_name: Sottocorno - first_name: Fabio full_name: Rigamonti, Fabio last_name: Rigamonti - first_name: Daniel full_name: D’Orazio, Daniel last_name: D’Orazio - first_name: Michael full_name: Eracleous, Michael last_name: Eracleous - first_name: Zoltán full_name: Haiman, Zoltán id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36 last_name: Haiman orcid: 0000-0003-3633-5403 - first_name: Massimo full_name: Dotti, Massimo last_name: Dotti citation: ama: Bertassi L, Sottocorno E, Rigamonti F, et al. Testing compact massive black hole binary candidates through multi-epoch spectroscopy. Astronomy & Astrophysics. 2025;702. doi:10.1051/0004-6361/202554574 apa: Bertassi, L., Sottocorno, E., Rigamonti, F., D’Orazio, D., Eracleous, M., Haiman, Z., & Dotti, M. (2025). Testing compact massive black hole binary candidates through multi-epoch spectroscopy. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202554574 chicago: Bertassi, Lorenzo, Erika Sottocorno, Fabio Rigamonti, Daniel D’Orazio, Michael Eracleous, Zoltán Haiman, and Massimo Dotti. “Testing Compact Massive Black Hole Binary Candidates through Multi-Epoch Spectroscopy.” Astronomy & Astrophysics. EDP Sciences, 2025. https://doi.org/10.1051/0004-6361/202554574. ieee: L. Bertassi et al., “Testing compact massive black hole binary candidates through multi-epoch spectroscopy,” Astronomy & Astrophysics, vol. 702. EDP Sciences, 2025. ista: Bertassi L, Sottocorno E, Rigamonti F, D’Orazio D, Eracleous M, Haiman Z, Dotti M. 2025. Testing compact massive black hole binary candidates through multi-epoch spectroscopy. Astronomy & Astrophysics. 702, A165. mla: Bertassi, Lorenzo, et al. “Testing Compact Massive Black Hole Binary Candidates through Multi-Epoch Spectroscopy.” Astronomy & Astrophysics, vol. 702, A165, EDP Sciences, 2025, doi:10.1051/0004-6361/202554574. short: L. Bertassi, E. Sottocorno, F. Rigamonti, D. D’Orazio, M. Eracleous, Z. Haiman, M. Dotti, Astronomy & Astrophysics 702 (2025). date_created: 2025-11-24T14:23:22Z date_published: 2025-10-20T00:00:00Z date_updated: 2025-12-01T15:31:55Z day: '20' ddc: - '520' department: - _id: ZoHa doi: 10.1051/0004-6361/202554574 external_id: arxiv: - '2504.06349' isi: - '001597841900015' file: - access_level: open_access checksum: dbaf156cb6684bf5c3f5fb76fc890d5a content_type: application/pdf creator: dernst date_created: 2025-11-25T12:56:18Z date_updated: 2025-11-25T12:56:18Z file_id: '20693' file_name: 2025_AstronomyAstrophysics_Bertassi.pdf file_size: 2035081 relation: main_file success: 1 file_date_updated: 2025-11-25T12:56:18Z has_accepted_license: '1' intvolume: ' 702' isi: 1 language: - iso: eng month: '10' oa: 1 oa_version: Published Version publication: Astronomy & Astrophysics publication_identifier: eissn: - 1432-0746 issn: - 0004-6361 publication_status: published publisher: EDP Sciences quality_controlled: '1' scopus_import: '1' status: public title: Testing compact massive black hole binary candidates through multi-epoch spectroscopy tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 702 year: '2025' ... --- OA_place: publisher OA_type: diamond PlanS_conform: '1' _id: '20687' abstract: - lang: eng text: "Subgiants and early red giants are crucial for studying the first dredge-up, a key evolutionary phase in which the convective envelope deepens, mixing previously interior-processed material and bringing it to the surface. Yet, very few have been seismically characterized with Kepler because their oscillation frequencies are close to the 30 minute sampling frequency of the mission. We developed a new method as part of the new PyA2Z code of identifying super-Nyquist oscillators and inferring their global seismic parameters, νmax and large separation, Δν.\r\n\r\nApplying PyA2Z to 2065 Kepler targets, we seismically characterize 285 super-Nyquist and 168 close-to-Nyquist stars with masses from 0.8 to 1.6 M⊙. In combination with APOGEE spectroscopy, Gaia spectrophotometry, and stellar models, we derive stellar ages for the sample. There is good agreement between the predicted and actual positions of stars on the HR diagram (luminosity vs. effective temperature) as a function of mass and composition. While the timing of dredge-up is consistent with predictions, the magnitude and mass dependence show discrepancies with models, possibly due to uncertainties in model physics or calibration issues in observed abundance scales." acknowledgement: 'This paper includes data collected by the Kepler mission and obtained from the MAST data archive at the Space Telescope Science Institute (STScI). Funding for the Kepler mission is provided by the NASA Science Mission Directorate. STScI is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5–26555. R.A.G. acknowledges the support from the GOLF and PLATO Centre National D’Études Spatiales grants. S.M. acknowledges support by the Spanish Ministry of Science and Innovation with the grant number PID2019-107061GB-C66, and through AEI under the Severo Ochoa Centres of Excellence Programme 2020–2023 (CEX2019-000920-S). B.L. thanks École Normale Supérieure Paris-Saclay (France) for its stipend that made possible to fund a long stay abroad. SM, DHG, DGR, and RAG acknowledge support from the Spanish Ministry of Science and Innovation with the grant no. PID2023-149439NB-C41. PGB acknowledges support by the Spanish Ministry of Science and Innovation with the Ramón y Cajal fellowship number RYC-2021-033137-I and the number MRR4032204. PGB, DHG, DGR, and RAG acknowledge support from the Spanish Ministry of Science and Innovation with the grant no. PID2023-146453NB-100 (PLAtoSOnG). AS acknowledges support by the Spanish Ministry of Science, Innovation and Universities through the grant PID2023-149918NB-I00 and the program Unidad de Excelencia María de Maeztu CEX2020-001058-M, and Generalitat de Catalunya through grant 2021-SGR-1526. MHP acknowledges support from NASA grant 80NSSC24K0637. MHP acknowledges support from the Fundación Occident and the Instituto de Astrofísica de Canarias under the Visiting Researcher Programme 2022-2025 agreed between both institutions. DGR acknowledges support from the Juan de la Cierva program under contract JDC2022-049054-I. DHG acknowledges the support of a fellowship from “la Caixa” Foundation (ID 100010434). The fellowship code is LCF/BQ/DI23/11990068. Software: AstroPy (Astropy Collaboration 2013, 2018), Matplotlib (Hunter 2007), NumPy (Harris et al. 2020), SciPy (Virtanen et al. 2020)' article_number: A144 article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Bastien Raymond Bernard full_name: Liagre, Bastien Raymond Bernard id: 662f1873-cab4-11f0-a719-8087d302868d last_name: Liagre - first_name: R. A. full_name: García, R. A. last_name: García - first_name: S. full_name: Mathur, S. last_name: Mathur - first_name: M. H. full_name: Pinsonneault, M. H. last_name: Pinsonneault - first_name: A. full_name: Serenelli, A. last_name: Serenelli - first_name: J. C. full_name: Zinn, J. C. last_name: Zinn - first_name: K. full_name: Cao, K. last_name: Cao - first_name: D. full_name: Godoy-Rivera, D. last_name: Godoy-Rivera - first_name: J. full_name: Tayar, J. last_name: Tayar - first_name: P. G. full_name: Beck, P. G. last_name: Beck - first_name: D. H. full_name: Grossmann, D. H. last_name: Grossmann - first_name: D. B. full_name: Palakkatharappil, D. B. last_name: Palakkatharappil citation: ama: Liagre BRB, García RA, Mathur S, et al. Beyond the Nyquist frequency. Astronomy & Astrophysics. 2025;702. doi:10.1051/0004-6361/202555167 apa: Liagre, B. R. B., García, R. A., Mathur, S., Pinsonneault, M. H., Serenelli, A., Zinn, J. C., … Palakkatharappil, D. B. (2025). Beyond the Nyquist frequency. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202555167 chicago: Liagre, Bastien Raymond Bernard, R. A. García, S. Mathur, M. H. Pinsonneault, A. Serenelli, J. C. Zinn, K. Cao, et al. “Beyond the Nyquist Frequency.” Astronomy & Astrophysics. EDP Sciences, 2025. https://doi.org/10.1051/0004-6361/202555167. ieee: B. R. B. Liagre et al., “Beyond the Nyquist frequency,” Astronomy & Astrophysics, vol. 702. EDP Sciences, 2025. ista: Liagre BRB, García RA, Mathur S, Pinsonneault MH, Serenelli A, Zinn JC, Cao K, Godoy-Rivera D, Tayar J, Beck PG, Grossmann DH, Palakkatharappil DB. 2025. Beyond the Nyquist frequency. Astronomy & Astrophysics. 702, A144. mla: Liagre, Bastien Raymond Bernard, et al. “Beyond the Nyquist Frequency.” Astronomy & Astrophysics, vol. 702, A144, EDP Sciences, 2025, doi:10.1051/0004-6361/202555167. short: B.R.B. Liagre, R.A. García, S. Mathur, M.H. Pinsonneault, A. Serenelli, J.C. Zinn, K. Cao, D. Godoy-Rivera, J. Tayar, P.G. Beck, D.H. Grossmann, D.B. Palakkatharappil, Astronomy & Astrophysics 702 (2025). corr_author: '1' date_created: 2025-11-24T14:23:36Z date_published: 2025-10-01T00:00:00Z date_updated: 2025-12-01T15:32:48Z day: '01' ddc: - '520' doi: 10.1051/0004-6361/202555167 external_id: arxiv: - '2508.15654' isi: - '001597841900002' file: - access_level: open_access checksum: 38fd0aa23b6945dc22be90caf55bfb6c content_type: application/pdf creator: dernst date_created: 2025-11-26T10:46:24Z date_updated: 2025-11-26T10:46:24Z file_id: '20697' file_name: 2025_AstronomyAstrophysics_Liagre.pdf file_size: 3081589 relation: main_file success: 1 file_date_updated: 2025-11-26T10:46:24Z has_accepted_license: '1' intvolume: ' 702' isi: 1 language: - iso: eng month: '10' oa: 1 oa_version: Published Version publication: Astronomy & Astrophysics publication_identifier: eissn: - 1432-0746 issn: - 0004-6361 publication_status: published publisher: EDP Sciences quality_controlled: '1' scopus_import: '1' status: public title: Beyond the Nyquist frequency tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 702 year: '2025' ... --- OA_place: repository OA_type: green _id: '20688' abstract: - lang: eng text: 'We consider two-player zero-sum concurrent stochastic games (CSGs) played on graphs with reachability and safety objectives. These include degenerate classes such as Markov decision processes or turn-based stochastic games, which can be solved by linear or quadratic programming; however, in practice, value iteration (VI) outperforms the other approaches and is the most implemented method. Similarly, for CSGs, this practical performance makes VI an attractive alternative to the standard theoretical solution via the existential theory of reals.VI starts with an under-approximation of the sought values for each state and iteratively updates them, traditionally terminating once two consecutive approximations are ϵ-close. However, this stopping criterion lacks guarantees on the precision of the approximation, which is the goal of this work. We provide bounded (a.k.a. interval) VI for CSGs: it complements standard VI with a converging sequence of over-approximations and terminates once the over- and under-approximations are ϵ-close.' acknowledgement: This research was funded in part by the German Research Foundation (DFG) project 427755713 GOPro, the MUNI Award in Science and Humanities (MUNI/I/1757/2021) of the Grant Agency of Masaryk University, the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 101034413, and the ERC Starting Grant DEUCE (101077178). article_processing_charge: No arxiv: 1 author: - first_name: Marta full_name: Grobelna, Marta last_name: Grobelna - first_name: Jan full_name: Kretinsky, Jan id: 44CEF464-F248-11E8-B48F-1D18A9856A87 last_name: Kretinsky orcid: 0000-0002-8122-2881 - first_name: Maximilian full_name: Weininger, Maximilian id: 02ab0197-cc70-11ed-ab61-918e71f56881 last_name: Weininger orcid: 0000-0002-0163-2152 citation: ama: 'Grobelna M, Kretinsky J, Weininger M. Stopping criteria for value iteration on concurrent stochastic reachability and safety games. In: 2025 40th Annual ACM/IEEE Symposium on Logic in Computer Science. IEEE; 2025:568-580. doi:10.1109/lics65433.2025.00049' apa: 'Grobelna, M., Kretinsky, J., & Weininger, M. (2025). Stopping criteria for value iteration on concurrent stochastic reachability and safety games. In 2025 40th Annual ACM/IEEE Symposium on Logic in Computer Science (pp. 568–580). Singapore, Singapore: IEEE. https://doi.org/10.1109/lics65433.2025.00049' chicago: Grobelna, Marta, Jan Kretinsky, and Maximilian Weininger. “Stopping Criteria for Value Iteration on Concurrent Stochastic Reachability and Safety Games.” In 2025 40th Annual ACM/IEEE Symposium on Logic in Computer Science, 568–80. IEEE, 2025. https://doi.org/10.1109/lics65433.2025.00049. ieee: M. Grobelna, J. Kretinsky, and M. Weininger, “Stopping criteria for value iteration on concurrent stochastic reachability and safety games,” in 2025 40th Annual ACM/IEEE Symposium on Logic in Computer Science, Singapore, Singapore, 2025, pp. 568–580. ista: 'Grobelna M, Kretinsky J, Weininger M. 2025. Stopping criteria for value iteration on concurrent stochastic reachability and safety games. 2025 40th Annual ACM/IEEE Symposium on Logic in Computer Science. LICS: Logic in Computer Science, 568–580.' mla: Grobelna, Marta, et al. “Stopping Criteria for Value Iteration on Concurrent Stochastic Reachability and Safety Games.” 2025 40th Annual ACM/IEEE Symposium on Logic in Computer Science, IEEE, 2025, pp. 568–80, doi:10.1109/lics65433.2025.00049. short: M. Grobelna, J. Kretinsky, M. Weininger, in:, 2025 40th Annual ACM/IEEE Symposium on Logic in Computer Science, IEEE, 2025, pp. 568–580. conference: end_date: 2025-06-26 location: Singapore, Singapore name: 'LICS: Logic in Computer Science' start_date: 2025-06-23 corr_author: '1' date_created: 2025-11-24T14:23:49Z date_published: 2025-10-09T00:00:00Z date_updated: 2025-11-26T07:34:19Z day: '09' department: - _id: KrCh doi: 10.1109/lics65433.2025.00049 ec_funded: 1 external_id: arxiv: - '2505.21087' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2505.21087 month: '10' oa: 1 oa_version: Preprint page: 568-580 project: - _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c call_identifier: H2020 grant_number: '101034413' name: 'IST-BRIDGE: International postdoctoral program' publication: 2025 40th Annual ACM/IEEE Symposium on Logic in Computer Science publication_identifier: eisbn: - '9798331579005' publication_status: published publisher: IEEE quality_controlled: '1' scopus_import: '1' status: public title: Stopping criteria for value iteration on concurrent stochastic reachability and safety games type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2025' ...