---
OA_place: publisher
_id: '8983'
abstract:
- lang: eng
text: Metabolic adaptation is a critical feature of migrating cells. It tunes the
metabolic programs of migrating cells to allow them to efficiently exert their
crucial roles in development, inflammatory responses and tumor metastasis. Cell
migration through physically challenging contexts requires energy. However, how
the metabolic reprogramming that underlies in vivo cell invasion is controlled
is still unanswered. In my PhD project, I identify a novel conserved metabolic
shift in Drosophila melanogaster immune cells that by modulating their bioenergetic
potential controls developmentally programmed tissue invasion. We show that this
regulation requires a novel conserved nuclear protein, named Atossa. Atossa enhances
the transcription of a set of proteins, including an RNA helicase Porthos and
two metabolic enzymes, each of which increases the tissue invasion of leading
Drosophila macrophages and can rescue the atossa mutant phenotype. Porthos selectively
regulates the translational efficiency of a subset of mRNAs containing a 5’-UTR
cis-regulatory TOP-like sequence. These 5’TOPL mRNA targets encode mitochondrial-related
proteins, including subunits of mitochondrial oxidative phosphorylation (OXPHOS)
components III and V and other metabolic-related proteins. Porthos powers up mitochondrial
OXPHOS to engender a sufficient ATP supply, which is required for tissue invasion
of leading macrophages. Atossa’s two vertebrate orthologs rescue the invasion
defect. In my PhD project, I elucidate that Atossa displays a conserved developmental
metabolic control to modulate metabolic capacities and the cellular energy state,
through altered transcription and translation, to aid the tissue infiltration
of leading cells into energy demanding barriers.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: E-Lib
- _id: CampIT
acknowledgement: Also, I would like to express my appreciation and thanks to the Bioimaging
facility, LSF, GSO, library, and IT people at IST Austria.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Shamsi
full_name: Emtenani, Shamsi
id: 49D32318-F248-11E8-B48F-1D18A9856A87
last_name: Emtenani
orcid: 0000-0001-6981-6938
citation:
ama: Emtenani S. Metabolic regulation of Drosophila macrophage tissue invasion.
2020. doi:10.15479/AT:ISTA:8983
apa: Emtenani, S. (2020). Metabolic regulation of Drosophila macrophage tissue
invasion. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8983
chicago: Emtenani, Shamsi. “Metabolic Regulation of Drosophila Macrophage Tissue
Invasion.” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8983.
ieee: S. Emtenani, “Metabolic regulation of Drosophila macrophage tissue invasion,”
Institute of Science and Technology Austria, 2020.
ista: Emtenani S. 2020. Metabolic regulation of Drosophila macrophage tissue invasion.
Institute of Science and Technology Austria.
mla: Emtenani, Shamsi. Metabolic Regulation of Drosophila Macrophage Tissue Invasion.
Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8983.
short: S. Emtenani, Metabolic Regulation of Drosophila Macrophage Tissue Invasion,
Institute of Science and Technology Austria, 2020.
corr_author: '1'
date_created: 2020-12-30T15:41:26Z
date_published: 2020-12-30T00:00:00Z
date_updated: 2026-04-08T07:28:54Z
day: '30'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: DaSi
doi: 10.15479/AT:ISTA:8983
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language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: '141'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '8557'
relation: part_of_dissertation
status: public
- id: '6187'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
title: Metabolic regulation of Drosophila macrophage tissue invasion
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2020'
...
---
_id: '8557'
abstract:
- lang: eng
text: The infiltration of immune cells into tissues underlies the establishment
of tissue resident macrophages, and responses to infections and tumors. Yet the
mechanisms immune cells utilize to negotiate tissue barriers in living organisms
are not well understood, and a role for cortical actin has not been examined.
Here we find that the tissue invasion of Drosophila macrophages, also known as
plasmatocytes or hemocytes, utilizes enhanced cortical F-actin levels stimulated
by the Drosophila member of the fos proto oncogene transcription factor family
(Dfos, Kayak). RNA sequencing analysis and live imaging show that Dfos enhances
F-actin levels around the entire macrophage surface by increasing mRNA levels
of the membrane spanning molecular scaffold tetraspanin TM4SF, and the actin cross-linking
filamin Cheerio which are themselves required for invasion. Cortical F-actin levels
are critical as expressing a dominant active form of Diaphanous, a actin polymerizing
Formin, can rescue the Dfos Dominant Negative macrophage invasion defect. In vivo
imaging shows that Dfos is required to enhance the efficiency of the initial phases
of macrophage tissue entry. Genetic evidence argues that this Dfos-induced program
in macrophages counteracts the constraint produced by the tension of surrounding
tissues and buffers the mechanical properties of the macrophage nucleus from affecting
tissue entry. We thus identify tuning the cortical actin cytoskeleton through
Dfos as a key process allowing efficient forward movement of an immune cell into
surrounding tissues.
acknowledged_ssus:
- _id: LifeSc
acknowledgement: 'We thank the following for their contributions: The Drosophila Genomics
Resource Center supported by NIH grant 2P40OD010949-10A1 for plasmids, K. Brueckner.
B. Stramer, M. Uhlirova, O. Schuldiner, the Bloomington Drosophila Stock Center
supported by NIH grant P40OD018537 and the Vienna Drosophila Resource Center for
fly stocks, FlyBase (Thurmond et al., 2019) for essential genomic information, and
the BDGP in situ database for data (Tomancak et al., 2002, 2007). For antibodies,
we thank the Developmental Studies Hybridoma Bank, which was created by the Eunice
Kennedy Shriver National Institute of Child Health and Human Development of the
NIH, and is maintained at the University of Iowa, as well as J. Zeitlinger for her
generous gift of Dfos antibody. We thank the Vienna BioCenter Core Facilities for
RNA sequencing and analysis and the Life Scientific Service Units at IST Austria
for technical support and assistance with microscopy and FACS analysis. We thank
C.P. Heisenberg, P. Martin, M. Sixt and Siekhaus group members for discussions and
T.Hurd, A. Ratheesh and P. Rangan for comments on the manuscript. A.G. was supported
by the Austrian Science Fund (FWF) grant DASI_FWF01_P29638S, D.E.S. by Marie Curie
CIG 334077/IRTIM. M.S. is supported by the FWF, PhD program W1212 915 and the European
Research Council (ERC) Advanced grant (ERC-2015-AdG TNT-Tumors 694883). S.W. is
supported by an OEAW, DOC fellowship.'
article_processing_charge: No
author:
- first_name: Vera
full_name: Belyaeva, Vera
id: 47F080FE-F248-11E8-B48F-1D18A9856A87
last_name: Belyaeva
- first_name: Stephanie
full_name: Wachner, Stephanie
id: 2A95E7B0-F248-11E8-B48F-1D18A9856A87
last_name: Wachner
- first_name: Igor
full_name: Gridchyn, Igor
id: 4B60654C-F248-11E8-B48F-1D18A9856A87
last_name: Gridchyn
orcid: 0000-0002-1807-1929
- first_name: Markus
full_name: Linder, Markus
last_name: Linder
- first_name: Shamsi
full_name: Emtenani, Shamsi
id: 49D32318-F248-11E8-B48F-1D18A9856A87
last_name: Emtenani
orcid: 0000-0001-6981-6938
- first_name: Attila
full_name: György, Attila
id: 3BCEDBE0-F248-11E8-B48F-1D18A9856A87
last_name: György
orcid: 0000-0002-1819-198X
- first_name: Maria
full_name: Sibilia, Maria
last_name: Sibilia
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
citation:
ama: Belyaeva V, Wachner S, Gridchyn I, et al. Cortical actin properties controlled
by Drosophila Fos aid macrophage infiltration against surrounding tissue resistance.
bioRxiv. doi:10.1101/2020.09.18.301481
apa: Belyaeva, V., Wachner, S., Gridchyn, I., Linder, M., Emtenani, S., György,
A., … Siekhaus, D. E. (n.d.). Cortical actin properties controlled by Drosophila
Fos aid macrophage infiltration against surrounding tissue resistance. bioRxiv.
https://doi.org/10.1101/2020.09.18.301481
chicago: Belyaeva, Vera, Stephanie Wachner, Igor Gridchyn, Markus Linder, Shamsi
Emtenani, Attila György, Maria Sibilia, and Daria E Siekhaus. “Cortical Actin
Properties Controlled by Drosophila Fos Aid Macrophage Infiltration against Surrounding
Tissue Resistance.” BioRxiv, n.d. https://doi.org/10.1101/2020.09.18.301481.
ieee: V. Belyaeva et al., “Cortical actin properties controlled by Drosophila
Fos aid macrophage infiltration against surrounding tissue resistance,” bioRxiv.
.
ista: Belyaeva V, Wachner S, Gridchyn I, Linder M, Emtenani S, György A, Sibilia
M, Siekhaus DE. Cortical actin properties controlled by Drosophila Fos aid macrophage
infiltration against surrounding tissue resistance. bioRxiv, 10.1101/2020.09.18.301481.
mla: Belyaeva, Vera, et al. “Cortical Actin Properties Controlled by Drosophila
Fos Aid Macrophage Infiltration against Surrounding Tissue Resistance.” BioRxiv,
doi:10.1101/2020.09.18.301481.
short: V. Belyaeva, S. Wachner, I. Gridchyn, M. Linder, S. Emtenani, A. György,
M. Sibilia, D.E. Siekhaus, BioRxiv (n.d.).
corr_author: '1'
date_created: 2020-09-23T09:36:47Z
date_published: 2020-09-18T00:00:00Z
date_updated: 2026-04-14T22:31:08Z
day: '18'
department:
- _id: DaSi
- _id: JoCs
doi: 10.1101/2020.09.18.301481
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2020.09.18.301481
month: '09'
oa: 1
oa_version: Preprint
project:
- _id: 253B6E48-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P29638
name: The role of Drosophila TNF alpha in immune cell invasion
- _id: 2536F660-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '334077'
name: Investigating the role of transporters in invasive migration through junctions
- _id: 26199CA4-B435-11E9-9278-68D0E5697425
grant_number: '24800'
name: Implications of a TGFβ/Dpp-activated subpopulation for Drosophila macrophage
migration
publication: bioRxiv
publication_status: draft
related_material:
record:
- id: '10614'
relation: later_version
status: public
- id: '8983'
relation: dissertation_contains
status: public
status: public
title: Cortical actin properties controlled by Drosophila Fos aid macrophage infiltration
against surrounding tissue resistance
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
OA_place: publisher
_id: '8340'
abstract:
- lang: eng
text: Mitochondria are sites of oxidative phosphorylation in eukaryotic cells. Oxidative
phosphorylation operates by a chemiosmotic mechanism made possible by redox-driven
proton pumping machines which establish a proton motive force across the inner
mitochondrial membrane. This electrochemical proton gradient is used to drive
ATP synthesis, which powers the majority of cellular processes such as protein
synthesis, locomotion and signalling. In this thesis I investigate the structures
and molecular mechanisms of two inner mitochondrial proton pumping enzymes, respiratory
complex I and transhydrogenase. I present the first high-resolution structure
of the full transhydrogenase from any species, and a significantly improved structure
of complex I. Improving the resolution from 3.3 Å available previously to up to
2.3 Å in this thesis allowed us to model bound water molecules, crucial in the
proton pumping mechanism. For both enzymes, up to five cryo-EM datasets with different
substrates and inhibitors bound were solved to delineate the catalytic cycle and
understand the proton pumping mechanism. In transhydrogenase, the proton channel
is gated by reversible detachment of the NADP(H)-binding domain which opens the
proton channel to the opposite sites of the membrane. In complex I, the proton
channels are gated by reversible protonation of key glutamate and lysine residues
and breaking of the water wire connecting the proton pumps with the quinone reduction
site. The tight coupling between the redox and the proton pumping reactions in
transhydrogenase is achieved by controlling the NADP(H) exchange which can only
happen when the NADP(H)-binding domain interacts with the membrane domain. In
complex I, coupling is achieved by cycling of the whole complex between the closed
state, in which quinone can get reduced, and the open state, in which NADH can
induce quinol ejection from the binding pocket. On the basis of these results
I propose detailed mechanisms for catalytic cycles of transhydrogenase and complex
I that are consistent with a large amount of previous work. In both enzymes, conformational
and electrostatic mechanisms contribute to the overall catalytic process. Results
presented here could be used for better understanding of the human pathologies
arising from deficiencies of complex I or transhydrogenase and could be used to
develop novel therapies.
acknowledged_ssus:
- _id: EM-Fac
acknowledgement: 'I acknowledge the support of IST facilities, especially the Electron
Miscroscopy facility for providing training and resources. Special thanks also go
to cryo-EM specialists who helped me to collect the data present here: Dr Valentin
Hodirnau (IST Austria), Dr Tom Heuser (IMBA, Vienna), Dr Rebecca Thompson (Uni.
of Leeds) and Dr Jirka Nováček (CEITEC). This work has been supported by iNEXT,
project number 653706, funded by the Horizon 2020 programme of the European Union.
This project has received funding from the European Union’s Horizon 2020 research
and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 665385.'
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Domen
full_name: Kampjut, Domen
id: 37233050-F248-11E8-B48F-1D18A9856A87
last_name: Kampjut
orcid: 0000-0002-6018-3422
citation:
ama: Kampjut D. Molecular mechanisms of mitochondrial redox-coupled proton pumping
enzymes. 2020. doi:10.15479/AT:ISTA:8340
apa: Kampjut, D. (2020). Molecular mechanisms of mitochondrial redox-coupled
proton pumping enzymes. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8340
chicago: Kampjut, Domen. “Molecular Mechanisms of Mitochondrial Redox-Coupled Proton
Pumping Enzymes.” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8340.
ieee: D. Kampjut, “Molecular mechanisms of mitochondrial redox-coupled proton pumping
enzymes,” Institute of Science and Technology Austria, 2020.
ista: Kampjut D. 2020. Molecular mechanisms of mitochondrial redox-coupled proton
pumping enzymes. Institute of Science and Technology Austria.
mla: Kampjut, Domen. Molecular Mechanisms of Mitochondrial Redox-Coupled Proton
Pumping Enzymes. Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8340.
short: D. Kampjut, Molecular Mechanisms of Mitochondrial Redox-Coupled Proton Pumping
Enzymes, Institute of Science and Technology Austria, 2020.
corr_author: '1'
date_created: 2020-09-07T18:42:23Z
date_published: 2020-09-09T00:00:00Z
date_updated: 2026-04-08T07:43:58Z
day: '09'
ddc:
- '572'
degree_awarded: PhD
department:
- _id: LeSa
doi: 10.15479/AT:ISTA:8340
ec_funded: 1
file:
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checksum: dd270baf82121eb4472ad19d77bf227c
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: dkampjut
date_created: 2020-09-08T13:32:06Z
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date_created: 2020-09-14T15:02:20Z
date_updated: 2021-09-11T22:30:04Z
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has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: None
page: '242'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
isbn:
- 978-3-99078-008-4
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '6848'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
title: Molecular mechanisms of mitochondrial redox-coupled proton pumping enzymes
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2020'
...
---
_id: '7652'
abstract:
- lang: eng
text: Organisms cope with change by taking advantage of transcriptional regulators.
However, when faced with rare environments, the evolution of transcriptional regulators
and their promoters may be too slow. Here, we investigate whether the intrinsic
instability of gene duplication and amplification provides a generic alternative
to canonical gene regulation. Using real-time monitoring of gene-copy-number mutations
in Escherichia coli, we show that gene duplications and amplifications enable
adaptation to fluctuating environments by rapidly generating copy-number and,
therefore, expression-level polymorphisms. This amplification-mediated gene expression
tuning (AMGET) occurs on timescales that are similar to canonical gene regulation
and can respond to rapid environmental changes. Mathematical modelling shows that
amplifications also tune gene expression in stochastic environments in which transcription-factor-based
schemes are hard to evolve or maintain. The fleeting nature of gene amplifications
gives rise to a generic population-level mechanism that relies on genetic heterogeneity
to rapidly tune the expression of any gene, without leaving any genomic signature.
acknowledgement: We thank L. Hurst, N. Barton, M. Pleska, M. Steinrück, B. Kavcic
and A. Staron for input on the manuscript, and To. Bergmiller and R. Chait for help
with microfluidics experiments. I.T. is a recipient the OMV fellowship. R.G. is
a recipient of a DOC (Doctoral Fellowship Programme of the Austrian Academy of Sciences)
Fellowship of the Austrian Academy of Sciences.
article_processing_charge: No
article_type: original
author:
- first_name: Isabella
full_name: Tomanek, Isabella
id: 3981F020-F248-11E8-B48F-1D18A9856A87
last_name: Tomanek
orcid: 0000-0001-6197-363X
- first_name: Rok
full_name: Grah, Rok
id: 483E70DE-F248-11E8-B48F-1D18A9856A87
last_name: Grah
orcid: 0000-0003-2539-3560
- first_name: M.
full_name: Lagator, M.
last_name: Lagator
- first_name: A. M. C.
full_name: Andersson, A. M. C.
last_name: Andersson
- first_name: Jonathan P
full_name: Bollback, Jonathan P
id: 2C6FA9CC-F248-11E8-B48F-1D18A9856A87
last_name: Bollback
orcid: 0000-0002-4624-4612
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
- first_name: Calin C
full_name: Guet, Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
citation:
ama: Tomanek I, Grah R, Lagator M, et al. Gene amplification as a form of population-level
gene expression regulation. Nature Ecology & Evolution. 2020;4(4):612-625.
doi:10.1038/s41559-020-1132-7
apa: Tomanek, I., Grah, R., Lagator, M., Andersson, A. M. C., Bollback, J. P., Tkačik,
G., & Guet, C. C. (2020). Gene amplification as a form of population-level
gene expression regulation. Nature Ecology & Evolution. Springer Nature.
https://doi.org/10.1038/s41559-020-1132-7
chicago: Tomanek, Isabella, Rok Grah, M. Lagator, A. M. C. Andersson, Jonathan P
Bollback, Gašper Tkačik, and Calin C Guet. “Gene Amplification as a Form of Population-Level
Gene Expression Regulation.” Nature Ecology & Evolution. Springer Nature,
2020. https://doi.org/10.1038/s41559-020-1132-7.
ieee: I. Tomanek et al., “Gene amplification as a form of population-level
gene expression regulation,” Nature Ecology & Evolution, vol. 4, no.
4. Springer Nature, pp. 612–625, 2020.
ista: Tomanek I, Grah R, Lagator M, Andersson AMC, Bollback JP, Tkačik G, Guet CC.
2020. Gene amplification as a form of population-level gene expression regulation.
Nature Ecology & Evolution. 4(4), 612–625.
mla: Tomanek, Isabella, et al. “Gene Amplification as a Form of Population-Level
Gene Expression Regulation.” Nature Ecology & Evolution, vol. 4, no.
4, Springer Nature, 2020, pp. 612–25, doi:10.1038/s41559-020-1132-7.
short: I. Tomanek, R. Grah, M. Lagator, A.M.C. Andersson, J.P. Bollback, G. Tkačik,
C.C. Guet, Nature Ecology & Evolution 4 (2020) 612–625.
date_created: 2020-04-08T15:20:53Z
date_published: 2020-04-01T00:00:00Z
date_updated: 2026-04-14T22:31:10Z
day: '01'
ddc:
- '570'
department:
- _id: GaTk
- _id: CaGu
doi: 10.1038/s41559-020-1132-7
external_id:
isi:
- '000519008300005'
pmid:
- '32152532'
file:
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checksum: ef3bbf42023e30b2c24a6278025d2040
content_type: application/pdf
creator: dernst
date_created: 2020-10-09T09:56:01Z
date_updated: 2020-10-09T09:56:01Z
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file_size: 745242
relation: main_file
success: 1
file_date_updated: 2020-10-09T09:56:01Z
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intvolume: ' 4'
isi: 1
issue: '4'
language:
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month: '04'
oa: 1
oa_version: Submitted Version
page: 612-625
pmid: 1
project:
- _id: 267C84F4-B435-11E9-9278-68D0E5697425
name: Biophysically realistic genotype-phenotype maps for regulatory networks
publication: Nature Ecology & Evolution
publication_identifier:
issn:
- 2397-334X
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/how-to-thrive-without-gene-regulation/
record:
- id: '7016'
relation: research_data
status: public
- id: '7383'
relation: research_data
status: public
- id: '8155'
relation: dissertation_contains
status: public
- id: '8653'
relation: used_in_publication
status: public
scopus_import: '1'
status: public
title: Gene amplification as a form of population-level gene expression regulation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2020'
...
---
OA_place: publisher
_id: '8653'
abstract:
- lang: eng
text: "Mutations are the raw material of evolution and come in many different flavors.
Point mutations change a single letter in the DNA sequence, while copy number
mutations like duplications or deletions add or remove many letters of the DNA
sequence simultaneously. Each type of mutation exhibits specific properties like
its rate of formation and reversal. \r\nGene expression is a fundamental phenotype
that can be altered by both, point and copy number mutations. The following thesis
is concerned with the dynamics of gene expression evolution and how it is affected
by the properties exhibited by point and copy number mutations. Specifically,
we are considering i) copy number mutations during adaptation to fluctuating environments
and ii) the interaction of copy number and point mutations during adaptation to
constant environments. "
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Isabella
full_name: Tomanek, Isabella
id: 3981F020-F248-11E8-B48F-1D18A9856A87
last_name: Tomanek
orcid: 0000-0001-6197-363X
citation:
ama: Tomanek I. The evolution of gene expression by copy number and point mutations.
2020. doi:10.15479/AT:ISTA:8653
apa: Tomanek, I. (2020). The evolution of gene expression by copy number and
point mutations. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8653
chicago: Tomanek, Isabella. “The Evolution of Gene Expression by Copy Number and
Point Mutations.” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8653.
ieee: I. Tomanek, “The evolution of gene expression by copy number and point mutations,”
Institute of Science and Technology Austria, 2020.
ista: Tomanek I. 2020. The evolution of gene expression by copy number and point
mutations. Institute of Science and Technology Austria.
mla: Tomanek, Isabella. The Evolution of Gene Expression by Copy Number and Point
Mutations. Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8653.
short: I. Tomanek, The Evolution of Gene Expression by Copy Number and Point Mutations,
Institute of Science and Technology Austria, 2020.
corr_author: '1'
date_created: 2020-10-13T13:02:33Z
date_published: 2020-10-13T00:00:00Z
date_updated: 2026-04-08T07:29:19Z
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keyword:
- duplication
- amplification
- promoter
- CNV
- AMGET
- experimental evolution
- Escherichia coli
language:
- iso: eng
month: '10'
oa: 1
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page: '117'
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issn:
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publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
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status: public
supervisor:
- first_name: Calin C
full_name: Guet, Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
title: The evolution of gene expression by copy number and point mutations
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2020'
...
---
OA_place: publisher
_id: '8620'
abstract:
- lang: eng
text: "The development of the human brain occurs through a tightly regulated series
of dynamic and adaptive processes during prenatal and postnatal life. A disruption
of this strictly orchestrated series of events can lead to a number of neurodevelopmental
conditions, including Autism Spectrum Disorders (ASDs). ASDs are a very common,
etiologically and phenotypically heterogeneous group of disorders sharing the
core symptoms of social interaction and communication deficits and restrictive
and repetitive interests and behaviors. They are estimated to affect one in 59
individuals in the U.S. and, over the last three decades, mutations in more than
a hundred genetic loci have been convincingly linked to ASD pathogenesis. Yet,
for the vast majority of these ASD-risk genes their role during brain development
and precise molecular function still remain elusive.\r\nDe novo loss of function
mutations in the ubiquitin ligase-encoding gene Cullin 3 (CUL3) lead to ASD. In
the study described here, we used Cul3 mouse models to evaluate the consequences
of Cul3 mutations in vivo. Our results show that Cul3 heterozygous knockout mice
exhibit deficits in motor coordination as well as ASD-relevant social and cognitive
impairments. Cul3+/-, Cul3+/fl Emx1-Cre and Cul3fl/fl Emx1-Cre mutant brains display
cortical lamination abnormalities due to defective migration of post-mitotic excitatory
neurons, as well as reduced numbers of excitatory and inhibitory neurons. In line
with the observed abnormal cortical organization, Cul3 heterozygous deletion is
associated with decreased spontaneous excitatory and inhibitory activity in the
cortex. At the molecular level we show that Cul3 regulates cytoskeletal and adhesion
protein abundance in the mouse embryonic cortex. Abnormal regulation of cytoskeletal
proteins in Cul3 mutant neural cells results in atypical organization of the actin
mesh at the cell leading edge. Of note, heterozygous deletion of Cul3 in adult
mice does not induce the majority of the behavioral defects observed in constitutive
Cul3 haploinsufficient animals, pointing to a critical time-window for Cul3 deficiency.\r\nIn
conclusion, our data indicate that Cul3 plays a critical role in the regulation
of cytoskeletal proteins and neuronal migration. ASD-associated defects and behavioral
abnormalities are primarily due to dosage sensitive Cul3 functions at early brain
developmental stages."
acknowledged_ssus:
- _id: Bio
- _id: PreCl
acknowledgement: I would like to especially thank Armel Nicolas from the Proteomics
and Christoph Sommer from the Bioimaging Facilities for the data analysis, and to
thank the team of the Preclinical Facility, especially Sabina Deixler, Angela Schlerka,
Anita Lepold, Mihalea Mihai and Michael Schun for taking care of the mouse line
maintenance and their great support.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Jasmin
full_name: Morandell, Jasmin
id: 4739D480-F248-11E8-B48F-1D18A9856A87
last_name: Morandell
citation:
ama: Morandell J. Illuminating the role of Cul3 in autism spectrum disorder pathogenesis.
2020. doi:10.15479/AT:ISTA:8620
apa: Morandell, J. (2020). Illuminating the role of Cul3 in autism spectrum disorder
pathogenesis. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8620
chicago: Morandell, Jasmin. “Illuminating the Role of Cul3 in Autism Spectrum Disorder
Pathogenesis.” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8620.
ieee: J. Morandell, “Illuminating the role of Cul3 in autism spectrum disorder pathogenesis,”
Institute of Science and Technology Austria, 2020.
ista: Morandell J. 2020. Illuminating the role of Cul3 in autism spectrum disorder
pathogenesis. Institute of Science and Technology Austria.
mla: Morandell, Jasmin. Illuminating the Role of Cul3 in Autism Spectrum Disorder
Pathogenesis. Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8620.
short: J. Morandell, Illuminating the Role of Cul3 in Autism Spectrum Disorder Pathogenesis,
Institute of Science and Technology Austria, 2020.
corr_author: '1'
date_created: 2020-10-07T14:53:13Z
date_published: 2020-10-12T00:00:00Z
date_updated: 2026-04-14T09:07:16Z
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call_identifier: FWF
grant_number: W1232
name: Molecular Drug Targets
- _id: 05A0D778-7A3F-11EA-A408-12923DDC885E
grant_number: F7807
name: Stem Cell Modulation in Neural Development and Regeneration/ P07-Neural stem
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publication_identifier:
issn:
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status: public
supervisor:
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
title: Illuminating the role of Cul3 in autism spectrum disorder pathogenesis
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2020'
...
---
_id: '7800'
abstract:
- lang: eng
text: De novo loss of function mutations in the ubiquitin ligase-encoding gene Cullin3
(CUL3) lead to autism spectrum disorder (ASD). Here, we used Cul3 mouse models
to evaluate the consequences of Cul3 mutations in vivo. Our results show that
Cul3 haploinsufficient mice exhibit deficits in motor coordination as well as
ASD-relevant social and cognitive impairments. Cul3 mutant brain displays cortical
lamination abnormalities due to defective neuronal migration and reduced numbers
of excitatory and inhibitory neurons. In line with the observed abnormal columnar
organization, Cul3 haploinsufficiency is associated with decreased spontaneous
excitatory and inhibitory activity in the cortex. At the molecular level, employing
a quantitative proteomic approach, we show that Cul3 regulates cytoskeletal and
adhesion protein abundance in mouse embryos. Abnormal regulation of cytoskeletal
proteins in Cul3 mutant neuronal cells results in atypical organization of the
actin mesh at the cell leading edge, likely causing the observed migration deficits.
In contrast to these important functions early in development, Cul3 deficiency
appears less relevant at adult stages. In fact, induction of Cul3 haploinsufficiency
in adult mice does not result in the behavioral defects observed in constitutive
Cul3 haploinsufficient animals. Taken together, our data indicate that Cul3 has
a critical role in the regulation of cytoskeletal proteins and neuronal migration
and that ASD-associated defects and behavioral abnormalities are primarily due
to Cul3 functions at early developmental stages.
acknowledged_ssus:
- _id: PreCl
article_processing_charge: No
author:
- first_name: Jasmin
full_name: Morandell, Jasmin
id: 4739D480-F248-11E8-B48F-1D18A9856A87
last_name: Morandell
- first_name: Lena A
full_name: Schwarz, Lena A
id: 29A8453C-F248-11E8-B48F-1D18A9856A87
last_name: Schwarz
- first_name: Bernadette
full_name: Basilico, Bernadette
id: 36035796-5ACA-11E9-A75E-7AF2E5697425
last_name: Basilico
orcid: 0000-0003-1843-3173
- first_name: Saren
full_name: Tasciyan, Saren
id: 4323B49C-F248-11E8-B48F-1D18A9856A87
last_name: Tasciyan
orcid: 0000-0003-1671-393X
- first_name: Armel
full_name: Nicolas, Armel
id: 2A103192-F248-11E8-B48F-1D18A9856A87
last_name: Nicolas
- first_name: Christoph M
full_name: Sommer, Christoph M
id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
last_name: Sommer
orcid: 0000-0003-1216-9105
- first_name: Caroline
full_name: Kreuzinger, Caroline
id: 382077BA-F248-11E8-B48F-1D18A9856A87
last_name: Kreuzinger
- first_name: Lisa
full_name: Knaus, Lisa
id: 3B2ABCF4-F248-11E8-B48F-1D18A9856A87
last_name: Knaus
- first_name: Zoe
full_name: Dobler, Zoe
id: D23090A2-9057-11EA-883A-A8396FC7A38F
last_name: Dobler
- first_name: Emanuele
full_name: Cacci, Emanuele
last_name: Cacci
- first_name: Johann G
full_name: Danzl, Johann G
id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
last_name: Danzl
orcid: 0000-0001-8559-3973
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
citation:
ama: Morandell J, Schwarz LA, Basilico B, et al. Cul3 regulates cytoskeleton protein
homeostasis and cell migration during a critical window of brain development.
bioRxiv. doi:10.1101/2020.01.10.902064
apa: Morandell, J., Schwarz, L. A., Basilico, B., Tasciyan, S., Nicolas, A., Sommer,
C. M., … Novarino, G. (n.d.). Cul3 regulates cytoskeleton protein homeostasis
and cell migration during a critical window of brain development. bioRxiv.
Cold Spring Harbor Laboratory. https://doi.org/10.1101/2020.01.10.902064
chicago: Morandell, Jasmin, Lena A Schwarz, Bernadette Basilico, Saren Tasciyan,
Armel Nicolas, Christoph M Sommer, Caroline Kreuzinger, et al. “Cul3 Regulates
Cytoskeleton Protein Homeostasis and Cell Migration during a Critical Window of
Brain Development.” BioRxiv. Cold Spring Harbor Laboratory, n.d. https://doi.org/10.1101/2020.01.10.902064 .
ieee: J. Morandell et al., “Cul3 regulates cytoskeleton protein homeostasis
and cell migration during a critical window of brain development,” bioRxiv.
Cold Spring Harbor Laboratory.
ista: Morandell J, Schwarz LA, Basilico B, Tasciyan S, Nicolas A, Sommer CM, Kreuzinger
C, Knaus L, Dobler Z, Cacci E, Danzl JG, Novarino G. Cul3 regulates cytoskeleton
protein homeostasis and cell migration during a critical window of brain development.
bioRxiv, 10.1101/2020.01.10.902064
.
mla: Morandell, Jasmin, et al. “Cul3 Regulates Cytoskeleton Protein Homeostasis
and Cell Migration during a Critical Window of Brain Development.” BioRxiv,
Cold Spring Harbor Laboratory, doi:10.1101/2020.01.10.902064 .
short: J. Morandell, L.A. Schwarz, B. Basilico, S. Tasciyan, A. Nicolas, C.M. Sommer,
C. Kreuzinger, L. Knaus, Z. Dobler, E. Cacci, J.G. Danzl, G. Novarino, BioRxiv
(n.d.).
corr_author: '1'
date_created: 2020-05-05T14:31:33Z
date_published: 2020-01-11T00:00:00Z
date_updated: 2026-04-14T22:31:24Z
day: '11'
ddc:
- '570'
department:
- _id: JoDa
- _id: GaNo
- _id: LifeSc
doi: '10.1101/2020.01.10.902064 '
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month: '01'
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publication: bioRxiv
publication_status: draft
publisher: Cold Spring Harbor Laboratory
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title: Cul3 regulates cytoskeleton protein homeostasis and cell migration during a
critical window of brain development
tmp:
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legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
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short: CC BY-NC-ND (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
OA_place: repository
OA_type: green
_id: '7885'
abstract:
- lang: eng
text: Eukaryotic cells migrate by coupling the intracellular force of the actin
cytoskeleton to the environment. While force coupling is usually mediated by transmembrane
adhesion receptors, especially those of the integrin family, amoeboid cells such
as leukocytes can migrate extremely fast despite very low adhesive forces1. Here
we show that leukocytes cannot only migrate under low adhesion but can also transmit
forces in the complete absence of transmembrane force coupling. When confined
within three-dimensional environments, they use the topographical features of
the substrate to propel themselves. Here the retrograde flow of the actin cytoskeleton
follows the texture of the substrate, creating retrograde shear forces that are
sufficient to drive the cell body forwards. Notably, adhesion-dependent and adhesion-independent
migration are not mutually exclusive, but rather are variants of the same principle
of coupling retrograde actin flow to the environment and thus can potentially
operate interchangeably and simultaneously. As adhesion-free migration is independent
of the chemical composition of the environment, it renders cells completely autonomous
in their locomotive behaviour.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: M-Shop
acknowledgement: We thank A. Leithner and J. Renkawitz for discussion and critical
reading of the manuscript; J. Schwarz and M. Mehling for establishing the microfluidic
setups; the Bioimaging Facility of IST Austria for excellent support, as well as
the Life Science Facility and the Miba Machine Shop of IST Austria; and F. N. Arslan,
L. E. Burnett and L. Li for their work during their rotation in the IST PhD programme.
This work was supported by the European Research Council (ERC StG 281556 and CoG
724373) to M.S. and grants from the Austrian Science Fund (FWF P29911) and the WWTF
to M.S. M.H. was supported by the European Regional Development Fund Project (CZ.02.1.01/0.0/0.0/15_003/0000476).
F.G. received funding from the European Union’s Horizon 2020 research and innovation
programme under the Marie Skłodowska-Curie grant agreement no. 747687.
article_processing_charge: No
article_type: original
author:
- first_name: Anne
full_name: Reversat, Anne
id: 35B76592-F248-11E8-B48F-1D18A9856A87
last_name: Reversat
orcid: 0000-0003-0666-8928
- first_name: Florian R
full_name: Gärtner, Florian R
id: 397A88EE-F248-11E8-B48F-1D18A9856A87
last_name: Gärtner
orcid: 0000-0001-6120-3723
- first_name: Jack
full_name: Merrin, Jack
id: 4515C308-F248-11E8-B48F-1D18A9856A87
last_name: Merrin
orcid: 0000-0001-5145-4609
- first_name: Julian A
full_name: Stopp, Julian A
id: 489E3F00-F248-11E8-B48F-1D18A9856A87
last_name: Stopp
- first_name: Saren
full_name: Tasciyan, Saren
id: 4323B49C-F248-11E8-B48F-1D18A9856A87
last_name: Tasciyan
orcid: 0000-0003-1671-393X
- first_name: Juan L
full_name: Aguilera Servin, Juan L
id: 2A67C376-F248-11E8-B48F-1D18A9856A87
last_name: Aguilera Servin
orcid: 0000-0002-2862-8372
- first_name: Ingrid
full_name: De Vries, Ingrid
id: 4C7D837E-F248-11E8-B48F-1D18A9856A87
last_name: De Vries
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Miroslav
full_name: Hons, Miroslav
id: 4167FE56-F248-11E8-B48F-1D18A9856A87
last_name: Hons
orcid: 0000-0002-6625-3348
- first_name: Matthieu
full_name: Piel, Matthieu
last_name: Piel
- first_name: Andrew
full_name: Callan-Jones, Andrew
last_name: Callan-Jones
- first_name: Raphael
full_name: Voituriez, Raphael
last_name: Voituriez
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
citation:
ama: Reversat A, Gärtner FR, Merrin J, et al. Cellular locomotion using environmental
topography. Nature. 2020;582:582–585. doi:10.1038/s41586-020-2283-z
apa: Reversat, A., Gärtner, F. R., Merrin, J., Stopp, J. A., Tasciyan, S., Aguilera
Servin, J. L., … Sixt, M. K. (2020). Cellular locomotion using environmental topography.
Nature. Springer Nature. https://doi.org/10.1038/s41586-020-2283-z
chicago: Reversat, Anne, Florian R Gärtner, Jack Merrin, Julian A Stopp, Saren Tasciyan,
Juan L Aguilera Servin, Ingrid de Vries, et al. “Cellular Locomotion Using Environmental
Topography.” Nature. Springer Nature, 2020. https://doi.org/10.1038/s41586-020-2283-z.
ieee: A. Reversat et al., “Cellular locomotion using environmental topography,”
Nature, vol. 582. Springer Nature, pp. 582–585, 2020.
ista: Reversat A, Gärtner FR, Merrin J, Stopp JA, Tasciyan S, Aguilera Servin JL,
de Vries I, Hauschild R, Hons M, Piel M, Callan-Jones A, Voituriez R, Sixt MK.
2020. Cellular locomotion using environmental topography. Nature. 582, 582–585.
mla: Reversat, Anne, et al. “Cellular Locomotion Using Environmental Topography.”
Nature, vol. 582, Springer Nature, 2020, pp. 582–585, doi:10.1038/s41586-020-2283-z.
short: A. Reversat, F.R. Gärtner, J. Merrin, J.A. Stopp, S. Tasciyan, J.L. Aguilera
Servin, I. de Vries, R. Hauschild, M. Hons, M. Piel, A. Callan-Jones, R. Voituriez,
M.K. Sixt, Nature 582 (2020) 582–585.
date_created: 2020-05-24T22:01:01Z
date_published: 2020-06-25T00:00:00Z
date_updated: 2026-04-14T22:31:24Z
day: '25'
department:
- _id: NanoFab
- _id: Bio
- _id: MiSi
doi: 10.1038/s41586-020-2283-z
ec_funded: 1
external_id:
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- '000532688300008'
pmid:
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intvolume: ' 582'
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language:
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month: '06'
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page: 582–585
pmid: 1
project:
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call_identifier: FP7
grant_number: '281556'
name: Cytoskeletal force generation and force transduction of migrating leukocytes
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call_identifier: H2020
grant_number: '724373'
name: Cellular Navigation Along Spatial Gradients
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call_identifier: FWF
grant_number: P29911
name: Mechanical adaptation of lamellipodial actin
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publication: Nature
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eissn:
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issn:
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publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
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relation: press_release
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type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 582
year: '2020'
...
---
_id: '8131'
abstract:
- lang: eng
text: The possibility to generate construct valid animal models enabled the development
and testing of therapeutic strategies targeting the core features of autism spectrum
disorders (ASDs). At the same time, these studies highlighted the necessity of
identifying sensitive developmental time windows for successful therapeutic interventions.
Animal and human studies also uncovered the possibility to stratify the variety
of ASDs in molecularly distinct subgroups, potentially facilitating effective
treatment design. Here, we focus on the molecular pathways emerging as commonly
affected by mutations in diverse ASD-risk genes, on their role during critical
windows of brain development and the potential treatments targeting these biological
processes.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Bernadette
full_name: Basilico, Bernadette
id: 36035796-5ACA-11E9-A75E-7AF2E5697425
last_name: Basilico
orcid: 0000-0003-1843-3173
- first_name: Jasmin
full_name: Morandell, Jasmin
id: 4739D480-F248-11E8-B48F-1D18A9856A87
last_name: Morandell
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
citation:
ama: Basilico B, Morandell J, Novarino G. Molecular mechanisms for targeted ASD
treatments. Current Opinion in Genetics and Development. 2020;65(12):126-137.
doi:10.1016/j.gde.2020.06.004
apa: Basilico, B., Morandell, J., & Novarino, G. (2020). Molecular mechanisms
for targeted ASD treatments. Current Opinion in Genetics and Development.
Elsevier. https://doi.org/10.1016/j.gde.2020.06.004
chicago: Basilico, Bernadette, Jasmin Morandell, and Gaia Novarino. “Molecular Mechanisms
for Targeted ASD Treatments.” Current Opinion in Genetics and Development.
Elsevier, 2020. https://doi.org/10.1016/j.gde.2020.06.004.
ieee: B. Basilico, J. Morandell, and G. Novarino, “Molecular mechanisms for targeted
ASD treatments,” Current Opinion in Genetics and Development, vol. 65,
no. 12. Elsevier, pp. 126–137, 2020.
ista: Basilico B, Morandell J, Novarino G. 2020. Molecular mechanisms for targeted
ASD treatments. Current Opinion in Genetics and Development. 65(12), 126–137.
mla: Basilico, Bernadette, et al. “Molecular Mechanisms for Targeted ASD Treatments.”
Current Opinion in Genetics and Development, vol. 65, no. 12, Elsevier,
2020, pp. 126–37, doi:10.1016/j.gde.2020.06.004.
short: B. Basilico, J. Morandell, G. Novarino, Current Opinion in Genetics and Development
65 (2020) 126–137.
corr_author: '1'
date_created: 2020-07-19T22:00:58Z
date_published: 2020-12-01T00:00:00Z
date_updated: 2026-04-14T22:31:25Z
day: '01'
ddc:
- '570'
department:
- _id: GaNo
doi: 10.1016/j.gde.2020.06.004
ec_funded: 1
external_id:
isi:
- '000598918900019'
pmid:
- '32659636'
file:
- access_level: open_access
content_type: application/pdf
creator: dernst
date_created: 2020-07-22T06:47:45Z
date_updated: 2020-07-22T06:47:45Z
file_id: '8146'
file_name: 2020_CurrentOpGenetics_Basilico.pdf
file_size: 1381545
relation: main_file
success: 1
file_date_updated: 2020-07-22T06:47:45Z
has_accepted_license: '1'
intvolume: ' 65'
isi: 1
issue: '12'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 126-137
pmid: 1
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: 2548AE96-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1232
name: Molecular Drug Targets
- _id: 05A0D778-7A3F-11EA-A408-12923DDC885E
grant_number: F7807
name: Stem Cell Modulation in Neural Development and Regeneration/ P07-Neural stem
cells in autism and epilepsy
publication: Current Opinion in Genetics and Development
publication_identifier:
eissn:
- 1879-0380
issn:
- 0959-437X
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '8620'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Molecular mechanisms for targeted ASD treatments
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 65
year: '2020'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21539'
abstract:
- lang: eng
text: The inability of conventional electronic architectures to efficiently solve
large combinatorial problems motivates the development of novel computational
hardware. There has been much effort toward developing application-specific hardware
across many different fields of engineering, such as integrated circuits, memristors,
and photonics. However, unleashing the potential of such architectures requires
the development of algorithms which optimally exploit their fundamental properties.
Here, we present the Photonic Recurrent Ising Sampler (PRIS), a heuristic method
tailored for parallel architectures allowing fast and efficient sampling from
distributions of arbitrary Ising problems. Since the PRIS relies on vector-to-fixed
matrix multiplications, we suggest the implementation of the PRIS in photonic
parallel networks, which realize these operations at an unprecedented speed. The
PRIS provides sample solutions to the ground state of Ising models, by converging
in probability to their associated Gibbs distribution. The PRIS also relies on
intrinsic dynamic noise and eigenvalue dropout to find ground states more efficiently.
Our work suggests speedups in heuristic methods via photonic implementations of
the PRIS.
article_number: '249'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Charles
full_name: Roques-Carmes, Charles
id: e2e68fc9-6505-11ef-a541-eb4e72cc3e82
last_name: Roques-Carmes
- first_name: Yichen
full_name: Shen, Yichen
last_name: Shen
- first_name: Cristian
full_name: Zanoci, Cristian
last_name: Zanoci
- first_name: Mihika
full_name: Prabhu, Mihika
last_name: Prabhu
- first_name: Fadi
full_name: Atieh, Fadi
last_name: Atieh
- first_name: Li
full_name: Jing, Li
last_name: Jing
- first_name: Tena
full_name: Dubček, Tena
last_name: Dubček
- first_name: Chenkai
full_name: Mao, Chenkai
last_name: Mao
- first_name: Miles R.
full_name: Johnson, Miles R.
last_name: Johnson
- first_name: Vladimir
full_name: Čeperić, Vladimir
last_name: Čeperić
- first_name: John D.
full_name: Joannopoulos, John D.
last_name: Joannopoulos
- first_name: Dirk
full_name: Englund, Dirk
last_name: Englund
- first_name: Marin
full_name: Soljačić, Marin
last_name: Soljačić
citation:
ama: Roques-Carmes C, Shen Y, Zanoci C, et al. Heuristic recurrent algorithms for
photonic Ising machines. Nature Communications. 2020;11. doi:10.1038/s41467-019-14096-z
apa: Roques-Carmes, C., Shen, Y., Zanoci, C., Prabhu, M., Atieh, F., Jing, L., …
Soljačić, M. (2020). Heuristic recurrent algorithms for photonic Ising machines.
Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-019-14096-z
chicago: Roques-Carmes, Charles, Yichen Shen, Cristian Zanoci, Mihika Prabhu, Fadi
Atieh, Li Jing, Tena Dubček, et al. “Heuristic Recurrent Algorithms for Photonic
Ising Machines.” Nature Communications. Springer Nature, 2020. https://doi.org/10.1038/s41467-019-14096-z.
ieee: C. Roques-Carmes et al., “Heuristic recurrent algorithms for photonic
Ising machines,” Nature Communications, vol. 11. Springer Nature, 2020.
ista: Roques-Carmes C, Shen Y, Zanoci C, Prabhu M, Atieh F, Jing L, Dubček T, Mao
C, Johnson MR, Čeperić V, Joannopoulos JD, Englund D, Soljačić M. 2020. Heuristic
recurrent algorithms for photonic Ising machines. Nature Communications. 11, 249.
mla: Roques-Carmes, Charles, et al. “Heuristic Recurrent Algorithms for Photonic
Ising Machines.” Nature Communications, vol. 11, 249, Springer Nature,
2020, doi:10.1038/s41467-019-14096-z.
short: C. Roques-Carmes, Y. Shen, C. Zanoci, M. Prabhu, F. Atieh, L. Jing, T. Dubček,
C. Mao, M.R. Johnson, V. Čeperić, J.D. Joannopoulos, D. Englund, M. Soljačić,
Nature Communications 11 (2020).
date_created: 2026-03-30T12:22:47Z
date_published: 2020-01-14T00:00:00Z
date_updated: 2026-04-15T06:15:50Z
day: '14'
ddc:
- '530'
doi: 10.1038/s41467-019-14096-z
extern: '1'
external_id:
arxiv:
- '1811.02705'
has_accepted_license: '1'
intvolume: ' 11'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41467-019-14096-z
month: '01'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Heuristic recurrent algorithms for photonic Ising machines
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2020'
...
---
_id: '8529'
abstract:
- lang: eng
text: Practical quantum networks require low-loss and noise-resilient optical interconnects
as well as non-Gaussian resources for entanglement distillation and distributed
quantum computation. The latter could be provided by superconducting circuits
but existing solutions to interface the microwave and optical domains lack either
scalability or efficiency, and in most cases the conversion noise is not known.
In this work we utilize the unique opportunities of silicon photonics, cavity
optomechanics and superconducting circuits to demonstrate a fully integrated,
coherent transducer interfacing the microwave X and the telecom S bands with a
total (internal) bidirectional transduction efficiency of 1.2% (135%) at millikelvin
temperatures. The coupling relies solely on the radiation pressure interaction
mediated by the femtometer-scale motion of two silicon nanobeams reaching a Vπ
as low as 16 μV for sub-nanowatt pump powers. Without the associated optomechanical
gain, we achieve a total (internal) pure conversion efficiency of up to 0.019%
(1.6%), relevant for future noise-free operation on this qubit-compatible platform.
acknowledged_ssus:
- _id: NanoFab
acknowledgement: We thank Yuan Chen for performing supplementary FEM simulations and
Andrew Higginbotham, Ralf Riedinger, Sungkun Hong, and Lorenzo Magrini for valuable
discussions. This work was supported by IST Austria, the IST nanofabrication facility
(NFF), the European Union’s Horizon 2020 research and innovation program under grant
agreement no. 732894 (FET Proactive HOT) and the European Research Council under
grant agreement no. 758053 (ERC StG QUNNECT). G.A. is the recipient of a DOC fellowship
of the Austrian Academy of Sciences at IST Austria. W.H. is the recipient of an
ISTplus postdoctoral fellowship with funding from the European Union’s Horizon 2020
research and innovation program under the Marie Sklodowska-Curie grant agreement
no. 754411. J.M.F. acknowledges support from the Austrian Science Fund (FWF) through
BeyondC (F71), a NOMIS foundation research grant, and the EU’s Horizon 2020 research
and innovation program under grant agreement no. 862644 (FET Open QUARTET).
article_number: '4460'
article_processing_charge: No
article_type: original
author:
- first_name: Georg M
full_name: Arnold, Georg M
id: 3770C838-F248-11E8-B48F-1D18A9856A87
last_name: Arnold
orcid: 0000-0003-1397-7876
- first_name: Matthias
full_name: Wulf, Matthias
id: 45598606-F248-11E8-B48F-1D18A9856A87
last_name: Wulf
orcid: 0000-0001-6613-1378
- first_name: Shabir
full_name: Barzanjeh, Shabir
id: 2D25E1F6-F248-11E8-B48F-1D18A9856A87
last_name: Barzanjeh
orcid: 0000-0003-0415-1423
- first_name: Elena
full_name: Redchenko, Elena
id: 2C21D6E8-F248-11E8-B48F-1D18A9856A87
last_name: Redchenko
- first_name: Alfredo R
full_name: Rueda Sanchez, Alfredo R
id: 3B82B0F8-F248-11E8-B48F-1D18A9856A87
last_name: Rueda Sanchez
orcid: 0000-0001-6249-5860
- first_name: William J
full_name: Hease, William J
id: 29705398-F248-11E8-B48F-1D18A9856A87
last_name: Hease
orcid: 0000-0001-9868-2166
- first_name: Farid
full_name: Hassani, Farid
id: 2AED110C-F248-11E8-B48F-1D18A9856A87
last_name: Hassani
orcid: 0000-0001-6937-5773
- first_name: Johannes M
full_name: Fink, Johannes M
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
citation:
ama: Arnold GM, Wulf M, Barzanjeh S, et al. Converting microwave and telecom photons
with a silicon photonic nanomechanical interface. Nature Communications.
2020;11. doi:10.1038/s41467-020-18269-z
apa: Arnold, G. M., Wulf, M., Barzanjeh, S., Redchenko, E., Rueda Sanchez, A. R.,
Hease, W. J., … Fink, J. M. (2020). Converting microwave and telecom photons with
a silicon photonic nanomechanical interface. Nature Communications. Springer
Nature. https://doi.org/10.1038/s41467-020-18269-z
chicago: Arnold, Georg M, Matthias Wulf, Shabir Barzanjeh, Elena Redchenko, Alfredo
R Rueda Sanchez, William J Hease, Farid Hassani, and Johannes M Fink. “Converting
Microwave and Telecom Photons with a Silicon Photonic Nanomechanical Interface.”
Nature Communications. Springer Nature, 2020. https://doi.org/10.1038/s41467-020-18269-z.
ieee: G. M. Arnold et al., “Converting microwave and telecom photons with
a silicon photonic nanomechanical interface,” Nature Communications, vol.
11. Springer Nature, 2020.
ista: Arnold GM, Wulf M, Barzanjeh S, Redchenko E, Rueda Sanchez AR, Hease WJ, Hassani
F, Fink JM. 2020. Converting microwave and telecom photons with a silicon photonic
nanomechanical interface. Nature Communications. 11, 4460.
mla: Arnold, Georg M., et al. “Converting Microwave and Telecom Photons with a Silicon
Photonic Nanomechanical Interface.” Nature Communications, vol. 11, 4460,
Springer Nature, 2020, doi:10.1038/s41467-020-18269-z.
short: G.M. Arnold, M. Wulf, S. Barzanjeh, E. Redchenko, A.R. Rueda Sanchez, W.J.
Hease, F. Hassani, J.M. Fink, Nature Communications 11 (2020).
corr_author: '1'
date_created: 2020-09-18T10:56:20Z
date_published: 2020-09-08T00:00:00Z
date_updated: 2026-04-15T06:37:01Z
day: '08'
ddc:
- '530'
department:
- _id: JoFi
doi: 10.1038/s41467-020-18269-z
ec_funded: 1
external_id:
isi:
- '000577280200001'
pmid:
- '32901014'
file:
- access_level: open_access
checksum: 88f92544889eb18bb38e25629a422a86
content_type: application/pdf
creator: dernst
date_created: 2020-09-18T13:02:37Z
date_updated: 2020-09-18T13:02:37Z
file_id: '8530'
file_name: 2020_NatureComm_Arnold.pdf
file_size: 1002818
relation: main_file
success: 1
file_date_updated: 2020-09-18T13:02:37Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
keyword:
- General Biochemistry
- Genetics and Molecular Biology
- General Physics and Astronomy
- General Chemistry
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 257EB838-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '732894'
name: Hybrid Optomechanical Technologies
- _id: 26336814-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '758053'
name: A Fiber Optic Transceiver for Superconducting Qubits
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: 237CBA6C-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '862644'
name: Quantum readout techniques and technologies
- _id: 2671EB66-B435-11E9-9278-68D0E5697425
name: Coherent on-chip conversion of superconducting qubit signals from microwaves
to optical frequencies
publication: Nature Communications
publication_identifier:
issn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1038/s41467-020-18912-9
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/how-to-transport-microwave-quantum-information-via-optical-fiber/
record:
- id: '13056'
relation: research_data
status: public
- id: '18871'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Converting microwave and telecom photons with a silicon photonic nanomechanical
interface
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2020'
...
---
_id: '8038'
abstract:
- lang: eng
text: Microelectromechanical systems and integrated photonics provide the basis
for many reliable and compact circuit elements in modern communication systems.
Electro-opto-mechanical devices are currently one of the leading approaches to
realize ultra-sensitive, low-loss transducers for an emerging quantum information
technology. Here we present an on-chip microwave frequency converter based on
a planar aluminum on silicon nitride platform that is compatible with slot-mode
coupled photonic crystal cavities. We show efficient frequency conversion between
two propagating microwave modes mediated by the radiation pressure interaction
with a metalized dielectric nanobeam oscillator. We achieve bidirectional coherent
conversion with a total device efficiency of up to ~60%, a dynamic range of 2
× 10^9 photons/s and an instantaneous bandwidth of up to 1.7 kHz. A high fidelity
quantum state transfer would be possible if the drive dependent output noise of
currently ~14 photons s^−1 Hz^−1 is further reduced. Such a silicon nitride based
transducer is in situ reconfigurable and could be used for on-chip classical and
quantum signal routing and filtering, both for microwave and hybrid microwave-optical
applications.
article_number: '034011'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Johannes M
full_name: Fink, Johannes M
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
- first_name: M.
full_name: Kalaee, M.
last_name: Kalaee
- first_name: R.
full_name: Norte, R.
last_name: Norte
- first_name: A.
full_name: Pitanti, A.
last_name: Pitanti
- first_name: O.
full_name: Painter, O.
last_name: Painter
citation:
ama: Fink JM, Kalaee M, Norte R, Pitanti A, Painter O. Efficient microwave frequency
conversion mediated by a photonics compatible silicon nitride nanobeam oscillator.
Quantum Science and Technology. 2020;5(3). doi:10.1088/2058-9565/ab8dce
apa: Fink, J. M., Kalaee, M., Norte, R., Pitanti, A., & Painter, O. (2020).
Efficient microwave frequency conversion mediated by a photonics compatible silicon
nitride nanobeam oscillator. Quantum Science and Technology. IOP Publishing.
https://doi.org/10.1088/2058-9565/ab8dce
chicago: Fink, Johannes M, M. Kalaee, R. Norte, A. Pitanti, and O. Painter. “Efficient
Microwave Frequency Conversion Mediated by a Photonics Compatible Silicon Nitride
Nanobeam Oscillator.” Quantum Science and Technology. IOP Publishing, 2020.
https://doi.org/10.1088/2058-9565/ab8dce.
ieee: J. M. Fink, M. Kalaee, R. Norte, A. Pitanti, and O. Painter, “Efficient microwave
frequency conversion mediated by a photonics compatible silicon nitride nanobeam
oscillator,” Quantum Science and Technology, vol. 5, no. 3. IOP Publishing,
2020.
ista: Fink JM, Kalaee M, Norte R, Pitanti A, Painter O. 2020. Efficient microwave
frequency conversion mediated by a photonics compatible silicon nitride nanobeam
oscillator. Quantum Science and Technology. 5(3), 034011.
mla: Fink, Johannes M., et al. “Efficient Microwave Frequency Conversion Mediated
by a Photonics Compatible Silicon Nitride Nanobeam Oscillator.” Quantum Science
and Technology, vol. 5, no. 3, 034011, IOP Publishing, 2020, doi:10.1088/2058-9565/ab8dce.
short: J.M. Fink, M. Kalaee, R. Norte, A. Pitanti, O. Painter, Quantum Science and
Technology 5 (2020).
corr_author: '1'
date_created: 2020-06-29T07:59:35Z
date_published: 2020-05-25T00:00:00Z
date_updated: 2026-04-15T06:42:07Z
day: '25'
ddc:
- '530'
department:
- _id: JoFi
doi: 10.1088/2058-9565/ab8dce
ec_funded: 1
external_id:
isi:
- '000539300800001'
file:
- access_level: open_access
checksum: 8f25f05053f511f892ae8fa93f341e61
content_type: application/pdf
creator: cziletti
date_created: 2020-06-30T10:29:10Z
date_updated: 2020-07-14T12:48:08Z
file_id: '8072'
file_name: 2020_QuantumSciTechnol_Fink.pdf
file_size: 2600967
relation: main_file
file_date_updated: 2020-07-14T12:48:08Z
has_accepted_license: '1'
intvolume: ' 5'
isi: 1
issue: '3'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
project:
- _id: 26336814-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '758053'
name: A Fiber Optic Transceiver for Superconducting Qubits
- _id: 257EB838-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '732894'
name: Hybrid Optomechanical Technologies
- _id: 2622978C-B435-11E9-9278-68D0E5697425
name: Hybrid Semiconductor - Superconductor Quantum Devices
- _id: bdb108fd-d553-11ed-ba76-83dc74a9864f
grant_number: F07105
name: QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration
of Superconducting Quantum Circuits
publication: Quantum Science and Technology
publication_identifier:
eissn:
- 2058-9565
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Efficient microwave frequency conversion mediated by a photonics compatible
silicon nitride nanobeam oscillator
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2020'
...
---
_id: '8755'
abstract:
- lang: eng
text: 'The superconducting circuit community has recently discovered the promising
potential of superinductors. These circuit elements have a characteristic impedance
exceeding the resistance quantum RQ ≈ 6.45 kΩ which leads to a suppression of
ground state charge fluctuations. Applications include the realization of hardware
protected qubits for fault tolerant quantum computing, improved coupling to small
dipole moment objects and defining a new quantum metrology standard for the ampere.
In this work we refute the widespread notion that superinductors can only be implemented
based on kinetic inductance, i.e. using disordered superconductors or Josephson
junction arrays. We present modeling, fabrication and characterization of 104
planar aluminum coil resonators with a characteristic impedance up to 30.9 kΩ
at 5.6 GHz and a capacitance down to ≤ 1 fF, with lowloss and a power handling
reaching 108 intra-cavity photons. Geometric superinductors are free of uncontrolled
tunneling events and offer high reproducibility, linearity and the ability to
couple magnetically - properties that significantly broaden the scope of future
quantum circuits. '
acknowledged_ssus:
- _id: NanoFab
acknowledgement: "The authors acknowledge the support from I. Prieto and the IST Nanofabrication
Facility. This work was supported by IST Austria and a NOMIS foundation research
grant and the Austrian Science Fund (FWF) through BeyondC (F71). MP is the recipient
of a P¨ottinger scholarship at IST Austria. JMF acknowledges support from the European
Union’s Horizon 2020 research and innovation programs under grant agreement No 732894
(FET Proactive HOT), 862644 (FET Open QUARTET), and the European Research Council
under grant agreement\r\nnumber 758053 (ERC StG QUNNECT). "
article_number: '044055'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Matilda
full_name: Peruzzo, Matilda
id: 3F920B30-F248-11E8-B48F-1D18A9856A87
last_name: Peruzzo
orcid: 0000-0002-3415-4628
- first_name: Andrea
full_name: Trioni, Andrea
id: 42F71B44-F248-11E8-B48F-1D18A9856A87
last_name: Trioni
- first_name: Farid
full_name: Hassani, Farid
id: 2AED110C-F248-11E8-B48F-1D18A9856A87
last_name: Hassani
orcid: 0000-0001-6937-5773
- first_name: Martin
full_name: Zemlicka, Martin
id: 2DCF8DE6-F248-11E8-B48F-1D18A9856A87
last_name: Zemlicka
orcid: 0009-0005-0878-3032
- first_name: Johannes M
full_name: Fink, Johannes M
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
citation:
ama: Peruzzo M, Trioni A, Hassani F, Zemlicka M, Fink JM. Surpassing the resistance
quantum with a geometric superinductor. Physical Review Applied. 2020;14(4).
doi:10.1103/PhysRevApplied.14.044055
apa: Peruzzo, M., Trioni, A., Hassani, F., Zemlicka, M., & Fink, J. M. (2020).
Surpassing the resistance quantum with a geometric superinductor. Physical
Review Applied. American Physical Society. https://doi.org/10.1103/PhysRevApplied.14.044055
chicago: Peruzzo, Matilda, Andrea Trioni, Farid Hassani, Martin Zemlicka, and Johannes
M Fink. “Surpassing the Resistance Quantum with a Geometric Superinductor.” Physical
Review Applied. American Physical Society, 2020. https://doi.org/10.1103/PhysRevApplied.14.044055.
ieee: M. Peruzzo, A. Trioni, F. Hassani, M. Zemlicka, and J. M. Fink, “Surpassing
the resistance quantum with a geometric superinductor,” Physical Review Applied,
vol. 14, no. 4. American Physical Society, 2020.
ista: Peruzzo M, Trioni A, Hassani F, Zemlicka M, Fink JM. 2020. Surpassing the
resistance quantum with a geometric superinductor. Physical Review Applied. 14(4),
044055.
mla: Peruzzo, Matilda, et al. “Surpassing the Resistance Quantum with a Geometric
Superinductor.” Physical Review Applied, vol. 14, no. 4, 044055, American
Physical Society, 2020, doi:10.1103/PhysRevApplied.14.044055.
short: M. Peruzzo, A. Trioni, F. Hassani, M. Zemlicka, J.M. Fink, Physical Review
Applied 14 (2020).
date_created: 2020-11-15T23:01:17Z
date_published: 2020-10-29T00:00:00Z
date_updated: 2026-04-15T06:43:02Z
day: '29'
ddc:
- '530'
department:
- _id: JoFi
doi: 10.1103/PhysRevApplied.14.044055
ec_funded: 1
external_id:
arxiv:
- '2007.01644'
isi:
- '000582797300003'
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language:
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month: '10'
oa: 1
oa_version: Published Version
project:
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call_identifier: H2020
grant_number: '732894'
name: Hybrid Optomechanical Technologies
- _id: 237CBA6C-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '862644'
name: Quantum readout techniques and technologies
- _id: 26336814-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '758053'
name: A Fiber Optic Transceiver for Superconducting Qubits
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grant_number: F07105
name: QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration
of Superconducting Quantum Circuits
publication: Physical Review Applied
publication_identifier:
eissn:
- 2331-7019
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
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relation: research_data
status: public
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relation: dissertation_contains
status: public
- id: '20371'
relation: dissertation_contains
status: public
- id: '17133'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Surpassing the resistance quantum with a geometric superinductor
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2020'
...
---
_id: '7910'
abstract:
- lang: eng
text: Quantum illumination uses entangled signal-idler photon pairs to boost the
detection efficiency of low-reflectivity objects in environments with bright thermal
noise. Its advantage is particularly evident at low signal powers, a promising
feature for applications such as noninvasive biomedical scanning or low-power
short-range radar. Here, we experimentally investigate the concept of quantum
illumination at microwave frequencies. We generate entangled fields to illuminate
a room-temperature object at a distance of 1 m in a free-space detection setup.
We implement a digital phase-conjugate receiver based on linear quadrature measurements
that outperforms a symmetric classical noise radar in the same conditions, despite
the entanglement-breaking signal path. Starting from experimental data, we also
simulate the case of perfect idler photon number detection, which results in a
quantum advantage compared with the relative classical benchmark. Our results
highlight the opportunities and challenges in the way toward a first room-temperature
application of microwave quantum circuits.
article_number: eabb0451
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Shabir
full_name: Barzanjeh, Shabir
id: 2D25E1F6-F248-11E8-B48F-1D18A9856A87
last_name: Barzanjeh
orcid: 0000-0003-0415-1423
- first_name: S.
full_name: Pirandola, S.
last_name: Pirandola
- first_name: D
full_name: Vitali, D
last_name: Vitali
- first_name: Johannes M
full_name: Fink, Johannes M
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
citation:
ama: Barzanjeh S, Pirandola S, Vitali D, Fink JM. Microwave quantum illumination
using a digital receiver. Science Advances. 2020;6(19). doi:10.1126/sciadv.abb0451
apa: Barzanjeh, S., Pirandola, S., Vitali, D., & Fink, J. M. (2020). Microwave
quantum illumination using a digital receiver. Science Advances. AAAS.
https://doi.org/10.1126/sciadv.abb0451
chicago: Barzanjeh, Shabir, S. Pirandola, D Vitali, and Johannes M Fink. “Microwave
Quantum Illumination Using a Digital Receiver.” Science Advances. AAAS,
2020. https://doi.org/10.1126/sciadv.abb0451.
ieee: S. Barzanjeh, S. Pirandola, D. Vitali, and J. M. Fink, “Microwave quantum
illumination using a digital receiver,” Science Advances, vol. 6, no. 19.
AAAS, 2020.
ista: Barzanjeh S, Pirandola S, Vitali D, Fink JM. 2020. Microwave quantum illumination
using a digital receiver. Science Advances. 6(19), eabb0451.
mla: Barzanjeh, Shabir, et al. “Microwave Quantum Illumination Using a Digital Receiver.”
Science Advances, vol. 6, no. 19, eabb0451, AAAS, 2020, doi:10.1126/sciadv.abb0451.
short: S. Barzanjeh, S. Pirandola, D. Vitali, J.M. Fink, Science Advances 6 (2020).
corr_author: '1'
date_created: 2020-05-31T22:00:49Z
date_published: 2020-05-06T00:00:00Z
date_updated: 2026-04-15T06:42:37Z
day: '06'
ddc:
- '530'
department:
- _id: JoFi
doi: 10.1126/sciadv.abb0451
ec_funded: 1
external_id:
arxiv:
- '1908.03058'
isi:
- '000531171100045'
pmid:
- '32548249'
file:
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checksum: 16fa61cc1951b444ee74c07188cda9da
content_type: application/pdf
creator: dernst
date_created: 2020-06-02T09:18:36Z
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file_size: 795822
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month: '05'
oa: 1
oa_version: Published Version
pmid: 1
project:
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call_identifier: H2020
grant_number: '758053'
name: A Fiber Optic Transceiver for Superconducting Qubits
- _id: 237CBA6C-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '862644'
name: Quantum readout techniques and technologies
- _id: 258047B6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '707438'
name: 'Microwave-to-Optical Quantum Link: Quantum Teleportation and Quantum Illumination
with cavity Optomechanics'
- _id: 257EB838-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '732894'
name: Hybrid Optomechanical Technologies
- _id: bdb108fd-d553-11ed-ba76-83dc74a9864f
grant_number: F07105
name: QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration
of Superconducting Quantum Circuits
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/scientists-demonstrate-quantum-radar-prototype/
record:
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relation: later_version
status: public
scopus_import: '1'
status: public
title: Microwave quantum illumination using a digital receiver
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2020'
...
---
_id: '9001'
abstract:
- lang: eng
text: Quantum illumination is a sensing technique that employs entangled signal-idler
beams to improve the detection efficiency of low-reflectivity objects in environments
with large thermal noise. The advantage over classical strategies is evident at
low signal brightness, a feature which could make the protocol an ideal prototype
for non-invasive scanning or low-power short-range radar. Here we experimentally
investigate the concept of quantum illumination at microwave frequencies, by generating
entangled fields using a Josephson parametric converter which are then amplified
to illuminate a room-temperature object at a distance of 1 meter. Starting from
experimental data, we simulate the case of perfect idler photon number detection,
which results in a quantum advantage compared to the relative classical benchmark.
Our results highlight the opportunities and challenges on the way towards a first
room-temperature application of microwave quantum circuits.
acknowledgement: "This work was supported by the Institute of Science and Technology
Austria (IST Austria), the European Research Council under grant agreement number
758053 (ERC StG QUNNECT) and the EU’s Horizon 2020 research and innovation programme
under grant agreement number 862644 (FET Open QUARTET). S.B. acknowledges support
from the Marie Skłodowska Curie\r\nfellowship number 707438 (MSC-IF SUPEREOM), DV
acknowledge support from EU’s Horizon 2020 research and innovation programme under
grant agreement number 732894 (FET Proactive HOT) and the Project QuaSeRT funded
by the QuantERA ERANET Cofund in Quantum Technologies, and J.M.F from the Austrian
Science Fund (FWF) through BeyondC (F71), a NOMIS foundation research grant, and
the EU’s Horizon 2020 research and\r\ninnovation programme under grant agreement
number 732894 (FET Proactive\r\nHOT)."
article_number: '9266397'
article_processing_charge: No
arxiv: 1
author:
- first_name: Shabir
full_name: Barzanjeh, Shabir
id: 2D25E1F6-F248-11E8-B48F-1D18A9856A87
last_name: Barzanjeh
orcid: 0000-0003-0415-1423
- first_name: Stefano
full_name: Pirandola, Stefano
last_name: Pirandola
- first_name: David
full_name: Vitali, David
last_name: Vitali
- first_name: Johannes M
full_name: Fink, Johannes M
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
citation:
ama: 'Barzanjeh S, Pirandola S, Vitali D, Fink JM. Microwave quantum illumination
with a digital phase-conjugated receiver. In: IEEE National Radar Conference
- Proceedings. Vol 2020. IEEE; 2020. doi:10.1109/RadarConf2043947.2020.9266397'
apa: 'Barzanjeh, S., Pirandola, S., Vitali, D., & Fink, J. M. (2020). Microwave
quantum illumination with a digital phase-conjugated receiver. In IEEE National
Radar Conference - Proceedings (Vol. 2020). Florence, Italy: IEEE. https://doi.org/10.1109/RadarConf2043947.2020.9266397'
chicago: Barzanjeh, Shabir, Stefano Pirandola, David Vitali, and Johannes M Fink.
“Microwave Quantum Illumination with a Digital Phase-Conjugated Receiver.” In
IEEE National Radar Conference - Proceedings, Vol. 2020. IEEE, 2020. https://doi.org/10.1109/RadarConf2043947.2020.9266397.
ieee: S. Barzanjeh, S. Pirandola, D. Vitali, and J. M. Fink, “Microwave quantum
illumination with a digital phase-conjugated receiver,” in IEEE National Radar
Conference - Proceedings, Florence, Italy, 2020, vol. 2020, no. 9.
ista: 'Barzanjeh S, Pirandola S, Vitali D, Fink JM. 2020. Microwave quantum illumination
with a digital phase-conjugated receiver. IEEE National Radar Conference - Proceedings.
RadarConf: National Conference on Radar vol. 2020, 9266397.'
mla: Barzanjeh, Shabir, et al. “Microwave Quantum Illumination with a Digital Phase-Conjugated
Receiver.” IEEE National Radar Conference - Proceedings, vol. 2020, no.
9, 9266397, IEEE, 2020, doi:10.1109/RadarConf2043947.2020.9266397.
short: S. Barzanjeh, S. Pirandola, D. Vitali, J.M. Fink, in:, IEEE National Radar
Conference - Proceedings, IEEE, 2020.
conference:
end_date: 2020-09-25
location: Florence, Italy
name: 'RadarConf: National Conference on Radar'
start_date: 2020-09-21
date_created: 2021-01-10T23:01:17Z
date_published: 2020-09-21T00:00:00Z
date_updated: 2026-04-15T06:42:36Z
day: '21'
department:
- _id: JoFi
doi: 10.1109/RadarConf2043947.2020.9266397
ec_funded: 1
external_id:
arxiv:
- '1908.03058'
isi:
- '000612224900089'
intvolume: ' 2020'
isi: 1
issue: '9'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1908.03058
month: '09'
oa: 1
oa_version: Preprint
project:
- _id: 26336814-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '758053'
name: A Fiber Optic Transceiver for Superconducting Qubits
- _id: 237CBA6C-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '862644'
name: Quantum readout techniques and technologies
- _id: 258047B6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '707438'
name: 'Microwave-to-Optical Quantum Link: Quantum Teleportation and Quantum Illumination
with cavity Optomechanics'
- _id: 257EB838-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '732894'
name: Hybrid Optomechanical Technologies
publication: IEEE National Radar Conference - Proceedings
publication_identifier:
isbn:
- '9781728189420'
issn:
- 1097-5659
publication_status: published
publisher: IEEE
quality_controlled: '1'
related_material:
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- id: '7910'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Microwave quantum illumination with a digital phase-conjugated receiver
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 2020
year: '2020'
...
---
_id: '13070'
abstract:
- lang: eng
text: This dataset comprises all data shown in the figures of the submitted article
"Surpassing the resistance quantum with a geometric superinductor". Additional
raw data are available from the corresponding author on reasonable request.
article_processing_charge: No
author:
- first_name: Matilda
full_name: Peruzzo, Matilda
id: 3F920B30-F248-11E8-B48F-1D18A9856A87
last_name: Peruzzo
orcid: 0000-0002-3415-4628
- first_name: Andrea
full_name: Trioni, Andrea
id: 42F71B44-F248-11E8-B48F-1D18A9856A87
last_name: Trioni
- first_name: Farid
full_name: Hassani, Farid
id: 2AED110C-F248-11E8-B48F-1D18A9856A87
last_name: Hassani
orcid: 0000-0001-6937-5773
- first_name: Martin
full_name: Zemlicka, Martin
id: 2DCF8DE6-F248-11E8-B48F-1D18A9856A87
last_name: Zemlicka
orcid: 0009-0005-0878-3032
- first_name: Johannes M
full_name: Fink, Johannes M
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
citation:
ama: Peruzzo M, Trioni A, Hassani F, Zemlicka M, Fink JM. Surpassing the resistance
quantum with a geometric superinductor. 2020. doi:10.5281/ZENODO.4052882
apa: Peruzzo, M., Trioni, A., Hassani, F., Zemlicka, M., & Fink, J. M. (2020).
Surpassing the resistance quantum with a geometric superinductor. Zenodo. https://doi.org/10.5281/ZENODO.4052882
chicago: Peruzzo, Matilda, Andrea Trioni, Farid Hassani, Martin Zemlicka, and Johannes
M Fink. “Surpassing the Resistance Quantum with a Geometric Superinductor.” Zenodo,
2020. https://doi.org/10.5281/ZENODO.4052882.
ieee: M. Peruzzo, A. Trioni, F. Hassani, M. Zemlicka, and J. M. Fink, “Surpassing
the resistance quantum with a geometric superinductor.” Zenodo, 2020.
ista: Peruzzo M, Trioni A, Hassani F, Zemlicka M, Fink JM. 2020. Surpassing the
resistance quantum with a geometric superinductor, Zenodo, 10.5281/ZENODO.4052882.
mla: Peruzzo, Matilda, et al. Surpassing the Resistance Quantum with a Geometric
Superinductor. Zenodo, 2020, doi:10.5281/ZENODO.4052882.
short: M. Peruzzo, A. Trioni, F. Hassani, M. Zemlicka, J.M. Fink, (2020).
corr_author: '1'
date_created: 2023-05-23T16:42:30Z
date_published: 2020-09-27T00:00:00Z
date_updated: 2026-04-15T06:43:02Z
day: '27'
ddc:
- '530'
department:
- _id: JoFi
doi: 10.5281/ZENODO.4052882
main_file_link:
- open_access: '1'
url: https://doi.org/10.5281/zenodo.4052883
month: '09'
oa: 1
oa_version: Published Version
publisher: Zenodo
related_material:
record:
- id: '8755'
relation: used_in_publication
status: public
status: public
title: Surpassing the resistance quantum with a geometric superinductor
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '9114'
abstract:
- lang: eng
text: "Microwave photonics lends the advantages of fiber optics to electronic sensing
and communication systems. In contrast to nonlinear optics, electro-optic devices
so far require classical modulation fields whose variance is dominated by electronic
or thermal noise rather than quantum fluctuations. Here we demonstrate bidirectional
single-sideband conversion of X band microwave to C band telecom light with a
microwave mode occupancy as low as 0.025 ± 0.005 and an added output noise of
less than or equal to 0.074 photons. This is facilitated by radiative cooling
and a triply resonant ultra-low-loss transducer operating at millikelvin temperatures.
The high bandwidth of 10.7 MHz and total (internal) photon conversion\r\nefficiency
of 0.03% (0.67%) combined with the extremely slow heating rate of 1.1 added output
noise photons per second for the highest available pump power of 1.48 mW puts
near-unity efficiency pulsed quantum transduction within reach. Together with
the non-Gaussian resources of superconducting qubits this might provide the practical
foundation to extend the range and scope of current quantum networks in analogy
to electrical repeaters in classical fiber optic communication."
acknowledged_ssus:
- _id: M-Shop
acknowledgement: "The authors acknowledge the support of T. Menner, A. Arslani, and
T. Asenov from the Miba machine shop for machining the microwave cavity, and thank
S. Barzanjeh, F. Sedlmeir, and C. Marquardt for fruitful discussions. This work
is supported by IST Austria and the European Research Council under Grant No. 758053
(ERC StG QUNNECT). W.H. is the recipient of an ISTplus postdoctoral fellowship with
funding from the European Union’s Horizon 2020 research and innovation program under
the Marie Skłodowska-Curie Grant No. 754411.\r\nG.A. is the recipient of a DOC fellowship
of the Austrian Academy of Sciences at IST Austria. J.M.F. acknowledges support
from the Austrian Science Fund (FWF) through BeyondC (F71) and the European Union’s
Horizon 2020 research and innovation program under Grant No. 899354 (FET Open SuperQuLAN).
H.G.L.S. acknowledges support from the Aotearoa/New Zealand’s MBIE Endeavour Smart
Ideas Grant No UOOX1805."
article_number: '020315'
article_processing_charge: No
article_type: original
author:
- first_name: William J
full_name: Hease, William J
id: 29705398-F248-11E8-B48F-1D18A9856A87
last_name: Hease
orcid: 0000-0001-9868-2166
- first_name: Alfredo R
full_name: Rueda Sanchez, Alfredo R
id: 3B82B0F8-F248-11E8-B48F-1D18A9856A87
last_name: Rueda Sanchez
orcid: 0000-0001-6249-5860
- first_name: Rishabh
full_name: Sahu, Rishabh
id: 47D26E34-F248-11E8-B48F-1D18A9856A87
last_name: Sahu
orcid: 0000-0001-6264-2162
- first_name: Matthias
full_name: Wulf, Matthias
id: 45598606-F248-11E8-B48F-1D18A9856A87
last_name: Wulf
orcid: 0000-0001-6613-1378
- first_name: Georg M
full_name: Arnold, Georg M
id: 3770C838-F248-11E8-B48F-1D18A9856A87
last_name: Arnold
orcid: 0000-0003-1397-7876
- first_name: Harald G.L.
full_name: Schwefel, Harald G.L.
last_name: Schwefel
- first_name: Johannes M
full_name: Fink, Johannes M
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
citation:
ama: Hease WJ, Rueda Sanchez AR, Sahu R, et al. Bidirectional electro-optic wavelength
conversion in the quantum ground state. PRX Quantum. 2020;1(2). doi:10.1103/prxquantum.1.020315
apa: Hease, W. J., Rueda Sanchez, A. R., Sahu, R., Wulf, M., Arnold, G. M., Schwefel,
H. G. L., & Fink, J. M. (2020). Bidirectional electro-optic wavelength conversion
in the quantum ground state. PRX Quantum. American Physical Society. https://doi.org/10.1103/prxquantum.1.020315
chicago: Hease, William J, Alfredo R Rueda Sanchez, Rishabh Sahu, Matthias Wulf,
Georg M Arnold, Harald G.L. Schwefel, and Johannes M Fink. “Bidirectional Electro-Optic
Wavelength Conversion in the Quantum Ground State.” PRX Quantum. American
Physical Society, 2020. https://doi.org/10.1103/prxquantum.1.020315.
ieee: W. J. Hease et al., “Bidirectional electro-optic wavelength conversion
in the quantum ground state,” PRX Quantum, vol. 1, no. 2. American Physical
Society, 2020.
ista: Hease WJ, Rueda Sanchez AR, Sahu R, Wulf M, Arnold GM, Schwefel HGL, Fink
JM. 2020. Bidirectional electro-optic wavelength conversion in the quantum ground
state. PRX Quantum. 1(2), 020315.
mla: Hease, William J., et al. “Bidirectional Electro-Optic Wavelength Conversion
in the Quantum Ground State.” PRX Quantum, vol. 1, no. 2, 020315, American
Physical Society, 2020, doi:10.1103/prxquantum.1.020315.
short: W.J. Hease, A.R. Rueda Sanchez, R. Sahu, M. Wulf, G.M. Arnold, H.G.L. Schwefel,
J.M. Fink, PRX Quantum 1 (2020).
corr_author: '1'
date_created: 2021-02-12T10:41:28Z
date_published: 2020-11-23T00:00:00Z
date_updated: 2026-04-15T06:43:27Z
day: '23'
ddc:
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department:
- _id: JoFi
doi: 10.1103/prxquantum.1.020315
ec_funded: 1
external_id:
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creator: dernst
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file_size: 2146924
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intvolume: ' 1'
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language:
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month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 26336814-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '758053'
name: A Fiber Optic Transceiver for Superconducting Qubits
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: 9B868D20-BA93-11EA-9121-9846C619BF3A
call_identifier: H2020
grant_number: '899354'
name: Quantum Local Area Networks with Superconducting Qubits
- _id: 2671EB66-B435-11E9-9278-68D0E5697425
name: Coherent on-chip conversion of superconducting qubit signals from microwaves
to optical frequencies
- _id: bdb108fd-d553-11ed-ba76-83dc74a9864f
grant_number: F07105
name: QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration
of Superconducting Quantum Circuits
publication: PRX Quantum
publication_identifier:
issn:
- 2691-3399
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/how-to-transport-microwave-quantum-information-via-optical-fiber/
record:
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relation: research_data
status: public
- id: '13175'
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relation: dissertation_contains
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relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Bidirectional electro-optic wavelength conversion in the quantum ground state
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1
year: '2020'
...
---
OA_place: publisher
OA_type: hybrid
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abstract:
- lang: eng
text: Recent progress in artificial intelligence is largely attributed to the rapid
development of machine learning, especially in the algorithm and neural network
models. However, it is the performance of the hardware, in particular the energy
efficiency of a computing system that sets the fundamental limit of the capability
of machine learning. Data-centric computing requires a revolution in hardware
systems, since traditional digital computers based on transistors and the von
Neumann architecture were not purposely designed for neuromorphic computing. A
hardware platform based on emerging devices and new architecture is the hope for
future computing with dramatically improved throughput and energy efficiency.
Building such a system, nevertheless, faces a number of challenges, ranging from
materials selection, device optimization, circuit fabrication and system integration,
to name a few. The aim of this Roadmap is to present a snapshot of emerging hardware
technologies that are potentially beneficial for machine learning, providing the
Nanotechnology readers with a perspective of challenges and opportunities in this
burgeoning field.
article_number: '012002'
article_processing_charge: No
article_type: original
author:
- first_name: Karl
full_name: Berggren, Karl
last_name: Berggren
- first_name: Qiangfei
full_name: Xia, Qiangfei
last_name: Xia
- first_name: Konstantin K
full_name: Likharev, Konstantin K
last_name: Likharev
- first_name: Dmitri B
full_name: Strukov, Dmitri B
last_name: Strukov
- first_name: Hao
full_name: Jiang, Hao
last_name: Jiang
- first_name: Thomas
full_name: Mikolajick, Thomas
last_name: Mikolajick
- first_name: Damien
full_name: Querlioz, Damien
last_name: Querlioz
- first_name: Martin
full_name: Salinga, Martin
last_name: Salinga
- first_name: John R
full_name: Erickson, John R
last_name: Erickson
- first_name: Shuang
full_name: Pi, Shuang
last_name: Pi
- first_name: Feng
full_name: Xiong, Feng
last_name: Xiong
- first_name: Peng
full_name: Lin, Peng
last_name: Lin
- first_name: Can
full_name: Li, Can
last_name: Li
- first_name: Yu
full_name: Chen, Yu
last_name: Chen
- first_name: Shisheng
full_name: Xiong, Shisheng
last_name: Xiong
- first_name: Brian D
full_name: Hoskins, Brian D
last_name: Hoskins
- first_name: Matthew W
full_name: Daniels, Matthew W
last_name: Daniels
- first_name: Advait
full_name: Madhavan, Advait
last_name: Madhavan
- first_name: James A
full_name: Liddle, James A
last_name: Liddle
- first_name: Jabez J
full_name: McClelland, Jabez J
last_name: McClelland
- first_name: Yuchao
full_name: Yang, Yuchao
last_name: Yang
- first_name: Jennifer
full_name: Rupp, Jennifer
last_name: Rupp
- first_name: Stephen S
full_name: Nonnenmann, Stephen S
last_name: Nonnenmann
- first_name: Kwang-Ting
full_name: Cheng, Kwang-Ting
last_name: Cheng
- first_name: Nanbo
full_name: Gong, Nanbo
last_name: Gong
- first_name: Miguel Angel
full_name: Lastras-Montaño, Miguel Angel
last_name: Lastras-Montaño
- first_name: A Alec
full_name: Talin, A Alec
last_name: Talin
- first_name: Alberto
full_name: Salleo, Alberto
last_name: Salleo
- first_name: Bhavin J
full_name: Shastri, Bhavin J
last_name: Shastri
- first_name: Thomas Ferreira
full_name: de Lima, Thomas Ferreira
last_name: de Lima
- first_name: Paul
full_name: Prucnal, Paul
last_name: Prucnal
- first_name: Alexander N
full_name: Tait, Alexander N
last_name: Tait
- first_name: Yichen
full_name: Shen, Yichen
last_name: Shen
- first_name: Huaiyu
full_name: Meng, Huaiyu
last_name: Meng
- first_name: Charles
full_name: Roques-Carmes, Charles
id: e2e68fc9-6505-11ef-a541-eb4e72cc3e82
last_name: Roques-Carmes
- first_name: Zengguang
full_name: Cheng, Zengguang
last_name: Cheng
- first_name: Harish
full_name: Bhaskaran, Harish
last_name: Bhaskaran
- first_name: Deep
full_name: Jariwala, Deep
last_name: Jariwala
- first_name: Han
full_name: Wang, Han
last_name: Wang
- first_name: Jeffrey M
full_name: Shainline, Jeffrey M
last_name: Shainline
- first_name: Kenneth
full_name: Segall, Kenneth
last_name: Segall
- first_name: J Joshua
full_name: Yang, J Joshua
last_name: Yang
- first_name: Kaushik
full_name: Roy, Kaushik
last_name: Roy
- first_name: Suman
full_name: Datta, Suman
last_name: Datta
- first_name: Arijit
full_name: Raychowdhury, Arijit
last_name: Raychowdhury
citation:
ama: Berggren K, Xia Q, Likharev KK, et al. Roadmap on emerging hardware and technology
for machine learning. Nanotechnology. 2020;32(1). doi:10.1088/1361-6528/aba70f
apa: Berggren, K., Xia, Q., Likharev, K. K., Strukov, D. B., Jiang, H., Mikolajick,
T., … Raychowdhury, A. (2020). Roadmap on emerging hardware and technology for
machine learning. Nanotechnology. IOP Publishing. https://doi.org/10.1088/1361-6528/aba70f
chicago: Berggren, Karl, Qiangfei Xia, Konstantin K Likharev, Dmitri B Strukov,
Hao Jiang, Thomas Mikolajick, Damien Querlioz, et al. “Roadmap on Emerging Hardware
and Technology for Machine Learning.” Nanotechnology. IOP Publishing, 2020.
https://doi.org/10.1088/1361-6528/aba70f.
ieee: K. Berggren et al., “Roadmap on emerging hardware and technology for
machine learning,” Nanotechnology, vol. 32, no. 1. IOP Publishing, 2020.
ista: Berggren K, Xia Q, Likharev KK, Strukov DB, Jiang H, Mikolajick T, Querlioz
D, Salinga M, Erickson JR, Pi S, Xiong F, Lin P, Li C, Chen Y, Xiong S, Hoskins
BD, Daniels MW, Madhavan A, Liddle JA, McClelland JJ, Yang Y, Rupp J, Nonnenmann
SS, Cheng K-T, Gong N, Lastras-Montaño MA, Talin AA, Salleo A, Shastri BJ, de
Lima TF, Prucnal P, Tait AN, Shen Y, Meng H, Roques-Carmes C, Cheng Z, Bhaskaran
H, Jariwala D, Wang H, Shainline JM, Segall K, Yang JJ, Roy K, Datta S, Raychowdhury
A. 2020. Roadmap on emerging hardware and technology for machine learning. Nanotechnology.
32(1), 012002.
mla: Berggren, Karl, et al. “Roadmap on Emerging Hardware and Technology for Machine
Learning.” Nanotechnology, vol. 32, no. 1, 012002, IOP Publishing, 2020,
doi:10.1088/1361-6528/aba70f.
short: K. Berggren, Q. Xia, K.K. Likharev, D.B. Strukov, H. Jiang, T. Mikolajick,
D. Querlioz, M. Salinga, J.R. Erickson, S. Pi, F. Xiong, P. Lin, C. Li, Y. Chen,
S. Xiong, B.D. Hoskins, M.W. Daniels, A. Madhavan, J.A. Liddle, J.J. McClelland,
Y. Yang, J. Rupp, S.S. Nonnenmann, K.-T. Cheng, N. Gong, M.A. Lastras-Montaño,
A.A. Talin, A. Salleo, B.J. Shastri, T.F. de Lima, P. Prucnal, A.N. Tait, Y. Shen,
H. Meng, C. Roques-Carmes, Z. Cheng, H. Bhaskaran, D. Jariwala, H. Wang, J.M.
Shainline, K. Segall, J.J. Yang, K. Roy, S. Datta, A. Raychowdhury, Nanotechnology
32 (2020).
date_created: 2026-03-30T12:22:47Z
date_published: 2020-10-19T00:00:00Z
date_updated: 2026-04-15T06:55:27Z
day: '19'
ddc:
- '530'
doi: 10.1088/1361-6528/aba70f
extern: '1'
external_id:
pmid:
- '32679577'
intvolume: ' 32'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1088/1361-6528/aba70f
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nanotechnology
publication_identifier:
eissn:
- 1361-6528
issn:
- 0957-4484
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Roadmap on emerging hardware and technology for machine learning
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 32
year: '2020'
...
---
_id: '13071'
abstract:
- lang: eng
text: This dataset comprises all data shown in the plots of the main part of the
submitted article "Bidirectional Electro-Optic Wavelength Conversion in the Quantum
Ground State". Additional raw data are available from the corresponding author
on reasonable request.
article_processing_charge: No
author:
- first_name: William J
full_name: Hease, William J
id: 29705398-F248-11E8-B48F-1D18A9856A87
last_name: Hease
orcid: 0000-0001-9868-2166
- first_name: Alfredo R
full_name: Rueda Sanchez, Alfredo R
id: 3B82B0F8-F248-11E8-B48F-1D18A9856A87
last_name: Rueda Sanchez
orcid: 0000-0001-6249-5860
- first_name: Rishabh
full_name: Sahu, Rishabh
id: 47D26E34-F248-11E8-B48F-1D18A9856A87
last_name: Sahu
orcid: 0000-0001-6264-2162
- first_name: Matthias
full_name: Wulf, Matthias
id: 45598606-F248-11E8-B48F-1D18A9856A87
last_name: Wulf
orcid: 0000-0001-6613-1378
- first_name: Georg M
full_name: Arnold, Georg M
id: 3770C838-F248-11E8-B48F-1D18A9856A87
last_name: Arnold
orcid: 0000-0003-1397-7876
- first_name: Harald
full_name: Schwefel, Harald
last_name: Schwefel
- first_name: Johannes M
full_name: Fink, Johannes M
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
citation:
ama: Hease WJ, Rueda Sanchez AR, Sahu R, et al. Bidirectional electro-optic wavelength
conversion in the quantum ground state. 2020. doi:10.5281/ZENODO.4266025
apa: Hease, W. J., Rueda Sanchez, A. R., Sahu, R., Wulf, M., Arnold, G. M., Schwefel,
H., & Fink, J. M. (2020). Bidirectional electro-optic wavelength conversion
in the quantum ground state. Zenodo. https://doi.org/10.5281/ZENODO.4266025
chicago: Hease, William J, Alfredo R Rueda Sanchez, Rishabh Sahu, Matthias Wulf,
Georg M Arnold, Harald Schwefel, and Johannes M Fink. “Bidirectional Electro-Optic
Wavelength Conversion in the Quantum Ground State.” Zenodo, 2020. https://doi.org/10.5281/ZENODO.4266025.
ieee: W. J. Hease et al., “Bidirectional electro-optic wavelength conversion
in the quantum ground state.” Zenodo, 2020.
ista: Hease WJ, Rueda Sanchez AR, Sahu R, Wulf M, Arnold GM, Schwefel H, Fink JM.
2020. Bidirectional electro-optic wavelength conversion in the quantum ground
state, Zenodo, 10.5281/ZENODO.4266025.
mla: Hease, William J., et al. Bidirectional Electro-Optic Wavelength Conversion
in the Quantum Ground State. Zenodo, 2020, doi:10.5281/ZENODO.4266025.
short: W.J. Hease, A.R. Rueda Sanchez, R. Sahu, M. Wulf, G.M. Arnold, H. Schwefel,
J.M. Fink, (2020).
corr_author: '1'
date_created: 2023-05-23T16:44:11Z
date_published: 2020-11-10T00:00:00Z
date_updated: 2026-04-15T06:43:26Z
day: '10'
ddc:
- '530'
department:
- _id: JoFi
doi: 10.5281/ZENODO.4266025
main_file_link:
- open_access: '1'
url: https://doi.org/10.5281/zenodo.4266026
month: '11'
oa: 1
oa_version: Published Version
publisher: Zenodo
related_material:
record:
- id: '9114'
relation: used_in_publication
status: public
status: public
title: Bidirectional electro-optic wavelength conversion in the quantum ground state
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '11499'
abstract:
- lang: eng
text: Deep optical spectroscopic surveys of galaxies provide a unique opportunity
to investigate rest-frame ultra-violet (UV) emission line properties of galaxies
at z ∼ 2 − 4.5. Here we combine VLT/MUSE Guaranteed Time Observations of the Hubble
Deep Field South, Ultra Deep Field, COSMOS, and several quasar fields with other
publicly available data from VLT/VIMOS and VLT/FORS2 to construct a catalogue
of He II λ1640 emitters at z ≳ 2. The deepest areas of our MUSE pointings reach
a 3σ line flux limit of 3.1 × 10−19 erg s−1 cm−2. After discarding broad-line
active galactic nuclei, we find 13 He II λ1640 detections from MUSE with a median
MUV = −20.1 and 21 tentative He II λ1640 detections from other public surveys.
Excluding Lyα, all except two galaxies in our sample show at least one other rest-UV
emission line, with C III] λ1907, λ1909 being the most prominent. We use multi-wavelength
data available in the Hubble legacy fields to derive basic galaxy properties of
our sample through spectral energy distribution fitting techniques. Taking advantage
of the high-quality spectra obtained by MUSE (∼10 − 30 h of exposure time per
pointing), we use photo-ionisation models to study the rest-UV emission line diagnostics
of the He II λ1640 emitters. Line ratios of our sample can be reproduced by moderately
sub-solar photo-ionisation models, however, we find that including effects of
binary stars lead to degeneracies in most free parameters. Even after considering
extra ionising photons produced by extreme sub-solar metallicity binary stellar
models, photo-ionisation models are unable to reproduce rest-frame He II λ1640
equivalent widths (∼0.2 − 10 Å), thus additional mechanisms are necessary in models
to match the observed He II λ1640 properties.
acknowledgement: 'The authors wish to thank the referee for constructive comments
that improved the paper substantially. We thank the BPASS team for making the stellar
population models available. We thank Elizabeth Stanway, Claus Leitherer, Daniel
Schaerer, Jorick Vink, and Nell Byler for insightful discussions. We thank the Lorentz
Centre and the scientific organizers of the Characterizing galaxies with spectroscopy
with a view for JWST workshop held at the Lorentz Centre in 2017 October, which
promoted useful discussions in the wider community. TN, JB, and RB acknowledges
the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) top grant TOP1.16.057.
AF acknowledges support from the ERC via an Advanced Grant under grant agreement
no. 339659-MUSICOS. JB acknowledges support by Fundação para a Ciência e a Tecnologia
(FCT) through national funds (UID/FIS/04434/2013) and Investigador FCT contract
IF/01654/2014/CP1215/CT0003, and by FEDER through COMPETE2020 (POCI-01-0145-FEDER-007672).
JR acknowledges support from the ERC Starting grant 336736 (CALENDS). This research
made use of astropy (http://www.astropy.org) a community-developed core Python package
for Astronomy (Astropy Collaboration 2013, 2018) and pandas (McKinney 2010). Figures
were generated using matplotlib (Hunter 2007) and seaborn (https://seaborn.pydata.org).
Facilities: VLT (MUSE).'
article_number: A89
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Themiya
full_name: Nanayakkara, Themiya
last_name: Nanayakkara
- first_name: Jarle
full_name: Brinchmann, Jarle
last_name: Brinchmann
- first_name: Leindert
full_name: Boogaard, Leindert
last_name: Boogaard
- first_name: Rychard
full_name: Bouwens, Rychard
last_name: Bouwens
- first_name: Sebastiano
full_name: Cantalupo, Sebastiano
last_name: Cantalupo
- first_name: Anna
full_name: Feltre, Anna
last_name: Feltre
- first_name: Wolfram
full_name: Kollatschny, Wolfram
last_name: Kollatschny
- first_name: Raffaella Anna
full_name: Marino, Raffaella Anna
last_name: Marino
- first_name: Michael
full_name: Maseda, Michael
last_name: Maseda
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Mieke
full_name: Paalvast, Mieke
last_name: Paalvast
- first_name: Johan
full_name: Richard, Johan
last_name: Richard
- first_name: Anne
full_name: Verhamme, Anne
last_name: Verhamme
citation:
ama: Nanayakkara T, Brinchmann J, Boogaard L, et al. Exploring He II λ1640 emission
line properties at z ∼2−4. Astronomy & Astrophysics. 2019;648. doi:10.1051/0004-6361/201834565
apa: Nanayakkara, T., Brinchmann, J., Boogaard, L., Bouwens, R., Cantalupo, S.,
Feltre, A., … Verhamme, A. (2019). Exploring He II λ1640 emission line properties
at z ∼2−4. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/201834565
chicago: Nanayakkara, Themiya, Jarle Brinchmann, Leindert Boogaard, Rychard Bouwens,
Sebastiano Cantalupo, Anna Feltre, Wolfram Kollatschny, et al. “Exploring He II Λ1640
Emission Line Properties at z ∼2−4.” Astronomy & Astrophysics. EDP
Sciences, 2019. https://doi.org/10.1051/0004-6361/201834565.
ieee: T. Nanayakkara et al., “Exploring He II λ1640 emission line properties
at z ∼2−4,” Astronomy & Astrophysics, vol. 648. EDP Sciences, 2019.
ista: Nanayakkara T, Brinchmann J, Boogaard L, Bouwens R, Cantalupo S, Feltre A,
Kollatschny W, Marino RA, Maseda M, Matthee JJ, Paalvast M, Richard J, Verhamme
A. 2019. Exploring He II λ1640 emission line properties at z ∼2−4. Astronomy &
Astrophysics. 648, A89.
mla: Nanayakkara, Themiya, et al. “Exploring He II Λ1640 Emission Line Properties
at z ∼2−4.” Astronomy & Astrophysics, vol. 648, A89, EDP Sciences,
2019, doi:10.1051/0004-6361/201834565.
short: T. Nanayakkara, J. Brinchmann, L. Boogaard, R. Bouwens, S. Cantalupo, A.
Feltre, W. Kollatschny, R.A. Marino, M. Maseda, J.J. Matthee, M. Paalvast, J.
Richard, A. Verhamme, Astronomy & Astrophysics 648 (2019).
date_created: 2022-07-06T09:07:06Z
date_published: 2019-04-16T00:00:00Z
date_updated: 2022-07-19T09:36:08Z
day: '16'
doi: 10.1051/0004-6361/201834565
extern: '1'
external_id:
arxiv:
- '1902.05960'
intvolume: ' 648'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: ISM / galaxies: star formation / galaxies: evolution / galaxies: high-redshift'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1902.05960
month: '04'
oa: 1
oa_version: Published Version
publication: Astronomy & Astrophysics
publication_identifier:
eissn:
- 1432-0746
issn:
- 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1051/0004-6361/201834565e
scopus_import: '1'
status: public
title: Exploring He II λ1640 emission line properties at z ∼2−4
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 648
year: '2019'
...