---
_id: '10622'
abstract:
- lang: eng
  text: We demonstrate a method for manipulating small ensembles of vortices in multiply
    connected superconducting structures. A micron-size magnetic particle attached
    to the tip of a silicon cantilever is used to locally apply magnetic flux through
    the superconducting structure. By scanning the tip over the surface of the device
    and by utilizing the dynamical coupling between the vortices and the cantilever,
    a high-resolution spatial map of the different vortex configurations is obtained.
    Moving the tip to a particular location in the map stabilizes a distinct multivortex
    configuration. Thus, the scanning of the tip over a particular trajectory in space
    permits nontrivial operations to be performed, such as braiding of individual
    vortices within a larger vortex ensemble—a key capability required by many proposals
    for topological quantum computing.
acknowledgement: We are grateful to Nadya Mason, Taylor Hughes, and Alexey Bezryadin
  for useful discussions. This work was supported by the DOE Basic Energy Sciences
  under DE-SC0012649 and the Department of Physics and the Frederick Seitz Materials
  Research Laboratory Central Facilities at the University of Illinois.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Hryhoriy
  full_name: Polshyn, Hryhoriy
  id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
  last_name: Polshyn
  orcid: 0000-0001-8223-8896
- first_name: Tyler
  full_name: Naibert, Tyler
  last_name: Naibert
- first_name: Raffi
  full_name: Budakian, Raffi
  last_name: Budakian
citation:
  ama: Polshyn H, Naibert T, Budakian R. Manipulating multivortex states in superconducting
    structures. <i>Nano Letters</i>. 2019;19(8):5476-5482. doi:<a href="https://doi.org/10.1021/acs.nanolett.9b01983">10.1021/acs.nanolett.9b01983</a>
  apa: Polshyn, H., Naibert, T., &#38; Budakian, R. (2019). Manipulating multivortex
    states in superconducting structures. <i>Nano Letters</i>. American Chemical Society.
    <a href="https://doi.org/10.1021/acs.nanolett.9b01983">https://doi.org/10.1021/acs.nanolett.9b01983</a>
  chicago: Polshyn, Hryhoriy, Tyler Naibert, and Raffi Budakian. “Manipulating Multivortex
    States in Superconducting Structures.” <i>Nano Letters</i>. American Chemical
    Society, 2019. <a href="https://doi.org/10.1021/acs.nanolett.9b01983">https://doi.org/10.1021/acs.nanolett.9b01983</a>.
  ieee: H. Polshyn, T. Naibert, and R. Budakian, “Manipulating multivortex states
    in superconducting structures,” <i>Nano Letters</i>, vol. 19, no. 8. American
    Chemical Society, pp. 5476–5482, 2019.
  ista: Polshyn H, Naibert T, Budakian R. 2019. Manipulating multivortex states in
    superconducting structures. Nano Letters. 19(8), 5476–5482.
  mla: Polshyn, Hryhoriy, et al. “Manipulating Multivortex States in Superconducting
    Structures.” <i>Nano Letters</i>, vol. 19, no. 8, American Chemical Society, 2019,
    pp. 5476–82, doi:<a href="https://doi.org/10.1021/acs.nanolett.9b01983">10.1021/acs.nanolett.9b01983</a>.
  short: H. Polshyn, T. Naibert, R. Budakian, Nano Letters 19 (2019) 5476–5482.
date_created: 2022-01-13T15:11:14Z
date_published: 2019-06-27T00:00:00Z
date_updated: 2022-01-13T15:41:24Z
day: '27'
doi: 10.1021/acs.nanolett.9b01983
extern: '1'
external_id:
  arxiv:
  - '1905.06303'
  pmid:
  - '31246034'
intvolume: '        19'
issue: '8'
keyword:
- mechanical engineering
- condensed matter physics
- general materials science
- general chemistry
- bioengineering
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1905.06303
month: '06'
oa: 1
oa_version: Preprint
page: 5476-5482
pmid: 1
publication: Nano Letters
publication_identifier:
  eissn:
  - 1530-6992
  issn:
  - 1530-6984
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Manipulating multivortex states in superconducting structures
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '2019'
...
---
_id: '10625'
abstract:
- lang: eng
  text: The discovery of superconductivity and exotic insulating phases in twisted
    bilayer graphene has established this material as a model system of strongly correlated
    electrons. To achieve superconductivity, the two layers of graphene need to be
    at a very precise angle with respect to each other. Yankowitz et al. now show
    that another experimental knob, hydrostatic pressure, can be used to tune the
    phase diagram of twisted bilayer graphene (see the Perspective by Feldman). Applying
    pressure increased the coupling between the layers, which shifted the superconducting
    transition to higher angles and somewhat higher temperatures.
acknowledgement: We thank J. Zhu and H. Zhou for experimental assistance and D. Shahar,
  A. Millis, O. Vafek, M. Zaletel, L. Balents, C. Xu, A. Bernevig, L. Fu, M. Koshino,
  and P. Moon for helpful discussions.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Matthew
  full_name: Yankowitz, Matthew
  last_name: Yankowitz
- first_name: Shaowen
  full_name: Chen, Shaowen
  last_name: Chen
- first_name: Hryhoriy
  full_name: Polshyn, Hryhoriy
  id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
  last_name: Polshyn
  orcid: 0000-0001-8223-8896
- first_name: Yuxuan
  full_name: Zhang, Yuxuan
  last_name: Zhang
- first_name: K.
  full_name: Watanabe, K.
  last_name: Watanabe
- first_name: T.
  full_name: Taniguchi, T.
  last_name: Taniguchi
- first_name: David
  full_name: Graf, David
  last_name: Graf
- first_name: Andrea F.
  full_name: Young, Andrea F.
  last_name: Young
- first_name: Cory R.
  full_name: Dean, Cory R.
  last_name: Dean
citation:
  ama: Yankowitz M, Chen S, Polshyn H, et al. Tuning superconductivity in twisted
    bilayer graphene. <i>Science</i>. 2019;363(6431):1059-1064. doi:<a href="https://doi.org/10.1126/science.aav1910">10.1126/science.aav1910</a>
  apa: Yankowitz, M., Chen, S., Polshyn, H., Zhang, Y., Watanabe, K., Taniguchi, T.,
    … Dean, C. R. (2019). Tuning superconductivity in twisted bilayer graphene. <i>Science</i>.
    American Association for the Advancement of Science (AAAS). <a href="https://doi.org/10.1126/science.aav1910">https://doi.org/10.1126/science.aav1910</a>
  chicago: Yankowitz, Matthew, Shaowen Chen, Hryhoriy Polshyn, Yuxuan Zhang, K. Watanabe,
    T. Taniguchi, David Graf, Andrea F. Young, and Cory R. Dean. “Tuning Superconductivity
    in Twisted Bilayer Graphene.” <i>Science</i>. American Association for the Advancement
    of Science (AAAS), 2019. <a href="https://doi.org/10.1126/science.aav1910">https://doi.org/10.1126/science.aav1910</a>.
  ieee: M. Yankowitz <i>et al.</i>, “Tuning superconductivity in twisted bilayer graphene,”
    <i>Science</i>, vol. 363, no. 6431. American Association for the Advancement of
    Science (AAAS), pp. 1059–1064, 2019.
  ista: Yankowitz M, Chen S, Polshyn H, Zhang Y, Watanabe K, Taniguchi T, Graf D,
    Young AF, Dean CR. 2019. Tuning superconductivity in twisted bilayer graphene.
    Science. 363(6431), 1059–1064.
  mla: Yankowitz, Matthew, et al. “Tuning Superconductivity in Twisted Bilayer Graphene.”
    <i>Science</i>, vol. 363, no. 6431, American Association for the Advancement of
    Science (AAAS), 2019, pp. 1059–64, doi:<a href="https://doi.org/10.1126/science.aav1910">10.1126/science.aav1910</a>.
  short: M. Yankowitz, S. Chen, H. Polshyn, Y. Zhang, K. Watanabe, T. Taniguchi, D.
    Graf, A.F. Young, C.R. Dean, Science 363 (2019) 1059–1064.
date_created: 2022-01-14T12:14:58Z
date_published: 2019-01-24T00:00:00Z
date_updated: 2022-01-14T13:48:32Z
day: '24'
doi: 10.1126/science.aav1910
extern: '1'
external_id:
  arxiv:
  - '1808.07865'
  pmid:
  - '30679385 '
intvolume: '       363'
issue: '6431'
keyword:
- multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1808.07865
month: '01'
oa: 1
oa_version: Preprint
page: 1059-1064
pmid: 1
publication: Science
publication_identifier:
  eissn:
  - 1095-9203
  issn:
  - 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science (AAAS)
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tuning superconductivity in twisted bilayer graphene
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 363
year: '2019'
...
---
_id: '10664'
abstract:
- lang: eng
  text: "Since the discovery of correlated insulators and superconductivity in magic-angle
    twisted bilayer graphene (tBLG) ([1, 2], JCCM April 2018), theorists have been
    excitedly pursuing the alluring mix of band topology, symmetry breaking, Mott
    insulators and superconductivity at play, as well as the potential relation (if
    any) to high-Tc physics. Now a new stream\r\nof experimental work is arriving
    which further enriches the story. To briefly recap Episodes 1 and 2 (JCCM April
    and November 2018), when two graphene layers are stacked with a small rotational
    mismatch θ, the resulting long-wavelength moire pattern leads to a superlattice
    potential which reconstructs the low energy band structure. When θ approaches
    the “magic-angle” θM ∼ 1 ◦, the band structure features eight nearly-flat bands
    which fill when the electron number per moire unit cell, n/n0, lies between −4
    < n/n0 < 4. The bands can be counted as 8 = 2 × 2 × 2: for each spin (2×) and
    valley (2×) characteristic of monolayergraphene, tBLG has has 2× flat bands which
    cross at mini-Dirac points."
article_processing_charge: No
article_type: original
author:
- first_name: Mathew
  full_name: Yankowitz, Mathew
  last_name: Yankowitz
- first_name: Shaowen
  full_name: Chen, Shaowen
  last_name: Chen
- first_name: Hryhoriy
  full_name: Polshyn, Hryhoriy
  id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
  last_name: Polshyn
  orcid: 0000-0001-8223-8896
- first_name: K.
  full_name: Watanabe, K.
  last_name: Watanabe
- first_name: T.
  full_name: Taniguchi, T.
  last_name: Taniguchi
- first_name: David
  full_name: Graf, David
  last_name: Graf
- first_name: Andrea F.
  full_name: Young, Andrea F.
  last_name: Young
- first_name: Cory R.
  full_name: Dean, Cory R.
  last_name: Dean
- first_name: Aaron L.
  full_name: Sharpe, Aaron L.
  last_name: Sharpe
- first_name: E.J.
  full_name: Fox, E.J.
  last_name: Fox
- first_name: A.W.
  full_name: Barnard, A.W.
  last_name: Barnard
- first_name: Joe
  full_name: Finney, Joe
  last_name: Finney
citation:
  ama: Yankowitz M, Chen S, Polshyn H, et al. New correlated phenomena in magic-angle
    twisted bilayer graphene/s. <i>Journal Club for Condensed Matter Physics</i>.
    2019;03. doi:<a href="https://doi.org/10.36471/jccm_february_2019_03">10.36471/jccm_february_2019_03</a>
  apa: Yankowitz, M., Chen, S., Polshyn, H., Watanabe, K., Taniguchi, T., Graf, D.,
    … Finney, J. (2019). New correlated phenomena in magic-angle twisted bilayer graphene/s.
    <i>Journal Club for Condensed Matter Physics</i>. Simons Foundation ; University
    of California, Riverside. <a href="https://doi.org/10.36471/jccm_february_2019_03">https://doi.org/10.36471/jccm_february_2019_03</a>
  chicago: Yankowitz, Mathew, Shaowen Chen, Hryhoriy Polshyn, K. Watanabe, T. Taniguchi,
    David Graf, Andrea F. Young, et al. “New Correlated Phenomena in Magic-Angle Twisted
    Bilayer Graphene/S.” <i>Journal Club for Condensed Matter Physics</i>. Simons
    Foundation ; University of California, Riverside, 2019. <a href="https://doi.org/10.36471/jccm_february_2019_03">https://doi.org/10.36471/jccm_february_2019_03</a>.
  ieee: M. Yankowitz <i>et al.</i>, “New correlated phenomena in magic-angle twisted
    bilayer graphene/s,” <i>Journal Club for Condensed Matter Physics</i>, vol. 03.
    Simons Foundation ; University of California, Riverside, 2019.
  ista: Yankowitz M, Chen S, Polshyn H, Watanabe K, Taniguchi T, Graf D, Young AF,
    Dean CR, Sharpe AL, Fox EJ, Barnard AW, Finney J. 2019. New correlated phenomena
    in magic-angle twisted bilayer graphene/s. Journal Club for Condensed Matter Physics.
    03.
  mla: Yankowitz, Mathew, et al. “New Correlated Phenomena in Magic-Angle Twisted
    Bilayer Graphene/S.” <i>Journal Club for Condensed Matter Physics</i>, vol. 03,
    Simons Foundation ; University of California, Riverside, 2019, doi:<a href="https://doi.org/10.36471/jccm_february_2019_03">10.36471/jccm_february_2019_03</a>.
  short: M. Yankowitz, S. Chen, H. Polshyn, K. Watanabe, T. Taniguchi, D. Graf, A.F.
    Young, C.R. Dean, A.L. Sharpe, E.J. Fox, A.W. Barnard, J. Finney, Journal Club
    for Condensed Matter Physics 03 (2019).
date_created: 2022-01-25T15:09:58Z
date_published: 2019-02-28T00:00:00Z
date_updated: 2025-01-14T14:28:17Z
day: '28'
doi: 10.36471/jccm_february_2019_03
extern: '1'
intvolume: '         3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.condmatjclub.org/?p=3541
month: '02'
oa: 1
oa_version: Published Version
publication: Journal Club for Condensed Matter Physics
publication_status: published
publisher: Simons Foundation ; University of California, Riverside
quality_controlled: '1'
status: public
title: New correlated phenomena in magic-angle twisted bilayer graphene/s
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: '03'
year: '2019'
...
---
_id: '10722'
abstract:
- lang: eng
  text: Bilayer graphene, rotationally faulted to ~1.1 degree misalignment, has recently
    been shown to host superconducting and resistive states associated with the formation
    of a flat electronic band. While numerous theories exist for the origins of both
    states, direct validation of these theories remains an outstanding experimental
    problem. Here, we focus on the resistive states occurring at commensurate filling
    (1/2, 1/4, and 3/4) of the two lowest superlattice bands. We test theoretical
    proposals that these states arise due to broken spin—and/or valley—symmetry by
    performing direct magnetic imaging with nanoscale SQUID-on-tip microscopy. This
    technique provides single-spin resolved magnetometry on sub-100nm length scales.
    I will present imaging data from our 4.2K nSOT microscope on graphite-gated twisted
    bilayers near the flat band condition and discuss the implications for the physics
    of the commensurate resistive states.
alternative_title:
- Bulletin of the American Physical Society
article_number: L14.00006
article_processing_charge: No
author:
- first_name: Marec
  full_name: Serlin, Marec
  last_name: Serlin
- first_name: Charles
  full_name: Tschirhart, Charles
  last_name: Tschirhart
- first_name: Hryhoriy
  full_name: Polshyn, Hryhoriy
  id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
  last_name: Polshyn
  orcid: 0000-0001-8223-8896
- first_name: Jiacheng
  full_name: Zhu, Jiacheng
  last_name: Zhu
- first_name: Martin E.
  full_name: Huber, Martin E.
  last_name: Huber
- first_name: Andrea
  full_name: Young, Andrea
  last_name: Young
citation:
  ama: 'Serlin M, Tschirhart C, Polshyn H, Zhu J, Huber ME, Young A. Direct Imaging
    of magnetic structure in twisted bilayer graphene with scanning nanoSQUID-On-Tip
    microscopy. In: <i>APS March Meeting 2019</i>. Vol 64. American Physical Society;
    2019.'
  apa: 'Serlin, M., Tschirhart, C., Polshyn, H., Zhu, J., Huber, M. E., &#38; Young,
    A. (2019). Direct Imaging of magnetic structure in twisted bilayer graphene with
    scanning nanoSQUID-On-Tip microscopy. In <i>APS March Meeting 2019</i> (Vol. 64).
    Boston, MA, United States: American Physical Society.'
  chicago: Serlin, Marec, Charles Tschirhart, Hryhoriy Polshyn, Jiacheng Zhu, Martin
    E. Huber, and Andrea Young. “Direct Imaging of Magnetic Structure in Twisted Bilayer
    Graphene with Scanning NanoSQUID-On-Tip Microscopy.” In <i>APS March Meeting 2019</i>,
    Vol. 64. American Physical Society, 2019.
  ieee: M. Serlin, C. Tschirhart, H. Polshyn, J. Zhu, M. E. Huber, and A. Young, “Direct
    Imaging of magnetic structure in twisted bilayer graphene with scanning nanoSQUID-On-Tip
    microscopy,” in <i>APS March Meeting 2019</i>, Boston, MA, United States, 2019,
    vol. 64, no. 2.
  ista: 'Serlin M, Tschirhart C, Polshyn H, Zhu J, Huber ME, Young A. 2019. Direct
    Imaging of magnetic structure in twisted bilayer graphene with scanning nanoSQUID-On-Tip
    microscopy. APS March Meeting 2019. APS: American Physical Society, Bulletin of
    the American Physical Society, vol. 64, L14.00006.'
  mla: Serlin, Marec, et al. “Direct Imaging of Magnetic Structure in Twisted Bilayer
    Graphene with Scanning NanoSQUID-On-Tip Microscopy.” <i>APS March Meeting 2019</i>,
    vol. 64, no. 2, L14.00006, American Physical Society, 2019.
  short: M. Serlin, C. Tschirhart, H. Polshyn, J. Zhu, M.E. Huber, A. Young, in:,
    APS March Meeting 2019, American Physical Society, 2019.
conference:
  end_date: 2019-03-08
  location: Boston, MA, United States
  name: 'APS: American Physical Society'
  start_date: 2019-03-04
date_created: 2022-02-04T11:54:21Z
date_published: 2019-03-01T00:00:00Z
date_updated: 2022-02-08T10:25:30Z
day: '01'
extern: '1'
intvolume: '        64'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://meetings.aps.org/Meeting/MAR19/Session/L14.6
month: '03'
oa: 1
oa_version: Published Version
publication: APS March Meeting 2019
publication_identifier:
  issn:
  - 0003-0503
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Direct Imaging of magnetic structure in twisted bilayer graphene with scanning
  nanoSQUID-On-Tip microscopy
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 64
year: '2019'
...
---
_id: '10723'
abstract:
- lang: eng
  text: In monolayer graphene, the interplay of electronic correlations with the internal
    spin- and valley- degrees of freedom leads to a complex phase diagram of isospin
    symmetry breaking at high magnetic fields. Recently, Wei et al. (Science (2018))
    demonstrated that spin waves can be electrically generated and detected in graphene
    heterojunctions, allowing direct experiment access to the spin degree of freedom.
    Here, we apply this technique to high quality graphite-gated graphene devices
    showing robust fractional quantum Hall phases and isospin phase transitions. We
    use an edgeless Corbino geometry to eliminate the contributions of edge states
    to the spin-wave mediated nonlocal voltage, allowing unambiguous identification
    of spin wave transport signatures. Our data reveal two phases within the ν = 1
    plateau. For exactly ν=1, charge is localized but spin waves propagate freely
    while small carrier doping completely quenches the low-energy spin-wave transport,
    even as those charges remain localized. We identify this new phase as a spin textured
    electron solid. We also find that spin-wave transport is modulated by phase transitions
    in the valley order that preserve spin polarization, suggesting that this technique
    is sensitive to both spin and valley order.
article_number: P01.00004
article_processing_charge: No
author:
- first_name: Haoxin
  full_name: Zhou, Haoxin
  last_name: Zhou
- first_name: Hryhoriy
  full_name: Polshyn, Hryhoriy
  id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
  last_name: Polshyn
  orcid: 0000-0001-8223-8896
- first_name: Takashi
  full_name: Tanaguchi, Takashi
  last_name: Tanaguchi
- first_name: Kenji
  full_name: Watanabe, Kenji
  last_name: Watanabe
- first_name: Andrea
  full_name: Young, Andrea
  last_name: Young
citation:
  ama: 'Zhou H, Polshyn H, Tanaguchi T, Watanabe K, Young A. Spin wave transport through
    electron solids and fractional quantum Hall liquids in graphene. In: <i>APS March
    Meeting 2019</i>. Vol 64. American Physical Society; 2019.'
  apa: 'Zhou, H., Polshyn, H., Tanaguchi, T., Watanabe, K., &#38; Young, A. (2019).
    Spin wave transport through electron solids and fractional quantum Hall liquids
    in graphene. In <i>APS March Meeting 2019</i> (Vol. 64). Boston, MA, United States:
    American Physical Society.'
  chicago: Zhou, Haoxin, Hryhoriy Polshyn, Takashi Tanaguchi, Kenji Watanabe, and
    Andrea Young. “Spin Wave Transport through Electron Solids and Fractional Quantum
    Hall Liquids in Graphene.” In <i>APS March Meeting 2019</i>, Vol. 64. American
    Physical Society, 2019.
  ieee: H. Zhou, H. Polshyn, T. Tanaguchi, K. Watanabe, and A. Young, “Spin wave transport
    through electron solids and fractional quantum Hall liquids in graphene,” in <i>APS
    March Meeting 2019</i>, Boston, MA, United States, 2019, vol. 64, no. 2.
  ista: 'Zhou H, Polshyn H, Tanaguchi T, Watanabe K, Young A. 2019. Spin wave transport
    through electron solids and fractional quantum Hall liquids in graphene. APS March
    Meeting 2019. APS: American Physical Society vol. 64, P01.00004.'
  mla: Zhou, Haoxin, et al. “Spin Wave Transport through Electron Solids and Fractional
    Quantum Hall Liquids in Graphene.” <i>APS March Meeting 2019</i>, vol. 64, no.
    2, P01.00004, American Physical Society, 2019.
  short: H. Zhou, H. Polshyn, T. Tanaguchi, K. Watanabe, A. Young, in:, APS March
    Meeting 2019, American Physical Society, 2019.
conference:
  end_date: 2019-03-08
  location: Boston, MA, United States
  name: 'APS: American Physical Society'
  start_date: 2019-03-04
date_created: 2022-02-04T12:14:02Z
date_published: 2019-03-01T00:00:00Z
date_updated: 2022-02-04T13:59:47Z
day: '01'
extern: '1'
intvolume: '        64'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://meetings.aps.org/Meeting/MAR19/Session/P01.4
month: '03'
oa: 1
oa_version: Published Version
publication: APS March Meeting 2019
publication_identifier:
  issn:
  - 0003-0503
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Spin wave transport through electron solids and fractional quantum Hall liquids
  in graphene
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 64
year: '2019'
...
---
_id: '10724'
abstract:
- lang: eng
  text: Twisted bilayer graphene (tBLG) near the flat band condition is a versatile
    new platform for the study of correlated physics in 2D. Resistive states have
    been observed at several commensurate fillings of the flat miniband, along with
    superconducting states near half filling. To better understand the electronic
    structure of this system, we study electronic transport of graphite gated superconducting
    tBLG devices in the normal regime. At high magnetic fields, we observe full lifting
    of the spin and valley degeneracy. The transitions in the splitting of this four-fold
    degeneracy as a function of carrier density indicate Landau level (LL) crossings,
    which tilted field measurements show occur between LLs with different valley polarization.
    Similar LL structure measured in two devices, one with twist angle θ=1.08° at
    ambient pressure and one at θ=1.27° and 1.33GPa, suggests that the dimensionless
    combination of twist angle and interlayer coupling controls the relevant details
    of the band structure. In addition, we find that the temperature dependence of
    the resistance at B=0 shows linear growth at several hundred Ohm/K in a broad
    range of temperatures. We discuss the implications for modeling the scattering
    processes in this system.
alternative_title:
- Bulletin of the American Physical Society
article_number: V14.00008
article_processing_charge: No
author:
- first_name: Hryhoriy
  full_name: Polshyn, Hryhoriy
  id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
  last_name: Polshyn
  orcid: 0000-0001-8223-8896
- first_name: Yuxuan
  full_name: Zhang, Yuxuan
  last_name: Zhang
- first_name: Matthew
  full_name: Yankowitz, Matthew
  last_name: Yankowitz
- first_name: Shaowen
  full_name: Chen, Shaowen
  last_name: Chen
- first_name: Takashi
  full_name: Taniguchi, Takashi
  last_name: Taniguchi
- first_name: Kenji
  full_name: Watanabe, Kenji
  last_name: Watanabe
- first_name: David E.
  full_name: Graf, David E.
  last_name: Graf
- first_name: Cory R.
  full_name: Dean, Cory R.
  last_name: Dean
- first_name: Andrea
  full_name: Young, Andrea
  last_name: Young
citation:
  ama: 'Polshyn H, Zhang Y, Yankowitz M, et al. Normal state transport in superconducting
    twisted bilayer graphene. In: <i>APS March Meeting 2019</i>. Vol 64. American
    Physical Society; 2019.'
  apa: 'Polshyn, H., Zhang, Y., Yankowitz, M., Chen, S., Taniguchi, T., Watanabe,
    K., … Young, A. (2019). Normal state transport in superconducting twisted bilayer
    graphene. In <i>APS March Meeting 2019</i> (Vol. 64). Boston, MA, United States:
    American Physical Society.'
  chicago: Polshyn, Hryhoriy, Yuxuan Zhang, Matthew Yankowitz, Shaowen Chen, Takashi
    Taniguchi, Kenji Watanabe, David E. Graf, Cory R. Dean, and Andrea Young. “Normal
    State Transport in Superconducting Twisted Bilayer Graphene.” In <i>APS March
    Meeting 2019</i>, Vol. 64. American Physical Society, 2019.
  ieee: H. Polshyn <i>et al.</i>, “Normal state transport in superconducting twisted
    bilayer graphene,” in <i>APS March Meeting 2019</i>, Boston, MA, United States,
    2019, vol. 64, no. 2.
  ista: 'Polshyn H, Zhang Y, Yankowitz M, Chen S, Taniguchi T, Watanabe K, Graf DE,
    Dean CR, Young A. 2019. Normal state transport in superconducting twisted bilayer
    graphene. APS March Meeting 2019. APS: American Physical Society, Bulletin of
    the American Physical Society, vol. 64, V14.00008.'
  mla: Polshyn, Hryhoriy, et al. “Normal State Transport in Superconducting Twisted
    Bilayer Graphene.” <i>APS March Meeting 2019</i>, vol. 64, no. 2, V14.00008, American
    Physical Society, 2019.
  short: H. Polshyn, Y. Zhang, M. Yankowitz, S. Chen, T. Taniguchi, K. Watanabe, D.E.
    Graf, C.R. Dean, A. Young, in:, APS March Meeting 2019, American Physical Society,
    2019.
conference:
  end_date: 2019-03-08
  location: Boston, MA, United States
  name: 'APS: American Physical Society'
  start_date: 2019-03-04
date_created: 2022-02-04T12:25:04Z
date_published: 2019-03-01T00:00:00Z
date_updated: 2022-02-08T10:23:13Z
day: '01'
extern: '1'
intvolume: '        64'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://meetings.aps.org/Meeting/MAR19/Session/V14.8
month: '03'
oa: 1
oa_version: Published Version
publication: APS March Meeting 2019
publication_identifier:
  issn:
  - 0003-0503
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Normal state transport in superconducting twisted bilayer graphene
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 64
year: '2019'
...
---
_id: '10725'
abstract:
- lang: eng
  text: Bilayer graphene with ~ 1.1 degrees twist mismatch between the layers hosts
    a low energy flat band in which the Coulomb interaction is large relative to the
    bandwidth, promoting correlated insulating states at half band filling, and superconducting
    (SC) phases with dome-like structure neighboring correlated insulating states.
    Here we show measurements of a dual-graphite-gated twisted bilayer graphene device,
    which minimizes charge inhomogeneity. We observe new correlated phases, including
    for the first time a SC pocket near half-filling of the electron-doped band and
    resistive states at quarter-filling of both bands that emerge in a magnetic field.
    Changing the layer polarization with vertical electric field reveals an unexpected
    competition between SC and correlated insulator phases, which we interpret to
    result from differences in disorder of each graphene layer and underscores the
    spatial inhomogeneity like twist angle as a significant source of disorder in
    these devices [1].
alternative_title:
- Bulletin of the American Physical Society
article_number: R14.00004
article_processing_charge: No
author:
- first_name: Shaowen
  full_name: Chen, Shaowen
  last_name: Chen
- first_name: Matthew
  full_name: Yankowitz, Matthew
  last_name: Yankowitz
- first_name: Hryhoriy
  full_name: Polshyn, Hryhoriy
  id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
  last_name: Polshyn
  orcid: 0000-0001-8223-8896
- first_name: Kenji
  full_name: Watanabe, Kenji
  last_name: Watanabe
- first_name: Takashi
  full_name: Taniguchi, Takashi
  last_name: Taniguchi
- first_name: David E.
  full_name: Graf, David E.
  last_name: Graf
- first_name: Andrea
  full_name: Young, Andrea
  last_name: Young
- first_name: Cory R.
  full_name: Dean, Cory R.
  last_name: Dean
citation:
  ama: 'Chen S, Yankowitz M, Polshyn H, et al. Correlated insulating and superconducting
    phases in twisted bilayer graphene. In: <i>APS March Meeting 2019</i>. Vol 64.
    American Physical Society; 2019.'
  apa: 'Chen, S., Yankowitz, M., Polshyn, H., Watanabe, K., Taniguchi, T., Graf, D.
    E., … Dean, C. R. (2019). Correlated insulating and superconducting phases in
    twisted bilayer graphene. In <i>APS March Meeting 2019</i> (Vol. 64). Boston,
    MA, United States: American Physical Society.'
  chicago: Chen, Shaowen, Matthew Yankowitz, Hryhoriy Polshyn, Kenji Watanabe, Takashi
    Taniguchi, David E. Graf, Andrea Young, and Cory R. Dean. “Correlated Insulating
    and Superconducting Phases in Twisted Bilayer Graphene.” In <i>APS March Meeting
    2019</i>, Vol. 64. American Physical Society, 2019.
  ieee: S. Chen <i>et al.</i>, “Correlated insulating and superconducting phases in
    twisted bilayer graphene,” in <i>APS March Meeting 2019</i>, Boston, MA, United
    States, 2019, vol. 64, no. 2.
  ista: 'Chen S, Yankowitz M, Polshyn H, Watanabe K, Taniguchi T, Graf DE, Young A,
    Dean CR. 2019. Correlated insulating and superconducting phases in twisted bilayer
    graphene. APS March Meeting 2019. APS: American Physical Society, Bulletin of
    the American Physical Society, vol. 64, R14.00004.'
  mla: Chen, Shaowen, et al. “Correlated Insulating and Superconducting Phases in
    Twisted Bilayer Graphene.” <i>APS March Meeting 2019</i>, vol. 64, no. 2, R14.00004,
    American Physical Society, 2019.
  short: S. Chen, M. Yankowitz, H. Polshyn, K. Watanabe, T. Taniguchi, D.E. Graf,
    A. Young, C.R. Dean, in:, APS March Meeting 2019, American Physical Society, 2019.
conference:
  end_date: 2019-03-08
  location: Boston, MA, United States
  name: 'APS: American Physical Society'
  start_date: 2019-03-04
date_created: 2022-02-04T13:48:04Z
date_published: 2019-03-01T00:00:00Z
date_updated: 2022-02-08T10:24:13Z
day: '01'
extern: '1'
intvolume: '        64'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://meetings.aps.org/Meeting/MAR19/Session/R14.4
month: '03'
oa: 1
oa_version: Published Version
publication: APS March Meeting 2019
publication_identifier:
  issn:
  - 0003-0503
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
  link:
  - relation: used_in_publication
    url: https://arxiv.org/abs/1808.07865
status: public
title: Correlated insulating and superconducting phases in twisted bilayer graphene
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 64
year: '2019'
...
---
_id: '10874'
abstract:
- lang: eng
  text: In this article we prove an analogue of a theorem of Lachaud, Ritzenthaler,
    and Zykin, which allows us to connect invariants of binary octics to Siegel modular
    forms of genus 3. We use this connection to show that certain modular functions,
    when restricted to the hyperelliptic locus, assume values whose denominators are
    products of powers of primes of bad reduction for the associated hyperelliptic
    curves. We illustrate our theorem with explicit computations. This work is motivated
    by the study of the values of these modular functions at CM points of the Siegel
    upper half-space, which, if their denominators are known, can be used to effectively
    compute models of (hyperelliptic, in our case) curves with CM.
acknowledgement: "The authors would like to thank the Lorentz Center in Leiden for
  hosting the Women in Numbers Europe 2 workshop and providing a productive and enjoyable
  environment for our initial work on this project. We are grateful to the organizers
  of WIN-E2, Irene Bouw, Rachel Newton and Ekin Ozman, for making this conference
  and this collaboration possible. We\r\nthank Irene Bouw and Christophe Ritzenhaler
  for helpful discussions. Ionica acknowledges support from the Thomas Jefferson Fund
  of the Embassy of France in the United States and the FACE Foundation. Most of Kılıçer’s
  work was carried out during her stay in Universiteit Leiden and Carl von Ossietzky
  Universität Oldenburg. Massierer was supported by the Australian Research Council
  (DP150101689). Vincent is supported by the National Science Foundation under Grant
  No. DMS-1802323 and by the Thomas Jefferson Fund of the Embassy of France in the
  United States and the FACE Foundation. "
article_number: '9'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Sorina
  full_name: Ionica, Sorina
  last_name: Ionica
- first_name: Pınar
  full_name: Kılıçer, Pınar
  last_name: Kılıçer
- first_name: Kristin
  full_name: Lauter, Kristin
  last_name: Lauter
- first_name: Elisa
  full_name: Lorenzo García, Elisa
  last_name: Lorenzo García
- first_name: Maria-Adelina
  full_name: Manzateanu, Maria-Adelina
  id: be8d652e-a908-11ec-82a4-e2867729459c
  last_name: Manzateanu
- first_name: Maike
  full_name: Massierer, Maike
  last_name: Massierer
- first_name: Christelle
  full_name: Vincent, Christelle
  last_name: Vincent
citation:
  ama: Ionica S, Kılıçer P, Lauter K, et al. Modular invariants for genus 3 hyperelliptic
    curves. <i>Research in Number Theory</i>. 2019;5. doi:<a href="https://doi.org/10.1007/s40993-018-0146-6">10.1007/s40993-018-0146-6</a>
  apa: Ionica, S., Kılıçer, P., Lauter, K., Lorenzo García, E., Manzateanu, M.-A.,
    Massierer, M., &#38; Vincent, C. (2019). Modular invariants for genus 3 hyperelliptic
    curves. <i>Research in Number Theory</i>. Springer Nature. <a href="https://doi.org/10.1007/s40993-018-0146-6">https://doi.org/10.1007/s40993-018-0146-6</a>
  chicago: Ionica, Sorina, Pınar Kılıçer, Kristin Lauter, Elisa Lorenzo García, Maria-Adelina
    Manzateanu, Maike Massierer, and Christelle Vincent. “Modular Invariants for Genus
    3 Hyperelliptic Curves.” <i>Research in Number Theory</i>. Springer Nature, 2019.
    <a href="https://doi.org/10.1007/s40993-018-0146-6">https://doi.org/10.1007/s40993-018-0146-6</a>.
  ieee: S. Ionica <i>et al.</i>, “Modular invariants for genus 3 hyperelliptic curves,”
    <i>Research in Number Theory</i>, vol. 5. Springer Nature, 2019.
  ista: Ionica S, Kılıçer P, Lauter K, Lorenzo García E, Manzateanu M-A, Massierer
    M, Vincent C. 2019. Modular invariants for genus 3 hyperelliptic curves. Research
    in Number Theory. 5, 9.
  mla: Ionica, Sorina, et al. “Modular Invariants for Genus 3 Hyperelliptic Curves.”
    <i>Research in Number Theory</i>, vol. 5, 9, Springer Nature, 2019, doi:<a href="https://doi.org/10.1007/s40993-018-0146-6">10.1007/s40993-018-0146-6</a>.
  short: S. Ionica, P. Kılıçer, K. Lauter, E. Lorenzo García, M.-A. Manzateanu, M.
    Massierer, C. Vincent, Research in Number Theory 5 (2019).
date_created: 2022-03-18T12:09:48Z
date_published: 2019-01-02T00:00:00Z
date_updated: 2023-09-05T15:39:31Z
day: '02'
department:
- _id: TiBr
doi: 10.1007/s40993-018-0146-6
external_id:
  arxiv:
  - '1807.08986'
intvolume: '         5'
keyword:
- Algebra and Number Theory
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1807.08986
month: '01'
oa: 1
oa_version: Preprint
publication: Research in Number Theory
publication_identifier:
  eissn:
  - 2363-9555
  issn:
  - 2522-0160
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modular invariants for genus 3 hyperelliptic curves
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 5
year: '2019'
...
---
_id: '10877'
abstract:
- lang: eng
  text: 'This report presents the results of a friendly competition for formal verification
    of continuous and hybrid systems with piecewise constant dynamics. The friendly
    competition took place as part of the workshop Applied Verification for Continuous
    and Hybrid Systems (ARCH) in 2019. In this third edition, six tools have been
    applied to solve five different benchmark problems in the category for piecewise
    constant dynamics: BACH, Lyse, Hy- COMP, PHAVer/SX, PHAVerLite, and VeriSiMPL.
    Compared to last year, a new tool has participated (HyCOMP) and PHAVerLite has
    replaced PHAVer-lite. The result is a snap- shot of the current landscape of tools
    and the types of benchmarks they are particularly suited for. Due to the diversity
    of problems, we are not ranking tools, yet the presented results probably provide
    the most complete assessment of tools for the safety verification of continuous
    and hybrid systems with piecewise constant dynamics up to this date.'
acknowledgement: "The authors gratefully acknowledge \fnancial support by the European
  Commission project\r\nUnCoVerCPS under grant number 643921. Lei Bu is supported
  by the National Natural Science\r\nFoundation of China (No.61572249)."
alternative_title:
- EPiC Series in Computing
article_processing_charge: No
author:
- first_name: Goran
  full_name: Frehse, Goran
  last_name: Frehse
- first_name: Alessandro
  full_name: Abate, Alessandro
  last_name: Abate
- first_name: Dieky
  full_name: Adzkiya, Dieky
  last_name: Adzkiya
- first_name: Anna
  full_name: Becchi, Anna
  last_name: Becchi
- first_name: Lei
  full_name: Bu, Lei
  last_name: Bu
- first_name: Alessandro
  full_name: Cimatti, Alessandro
  last_name: Cimatti
- first_name: Mirco
  full_name: Giacobbe, Mirco
  id: 3444EA5E-F248-11E8-B48F-1D18A9856A87
  last_name: Giacobbe
  orcid: 0000-0001-8180-0904
- first_name: Alberto
  full_name: Griggio, Alberto
  last_name: Griggio
- first_name: Sergio
  full_name: Mover, Sergio
  last_name: Mover
- first_name: Muhammad Syifa'ul
  full_name: Mufid, Muhammad Syifa'ul
  last_name: Mufid
- first_name: Idriss
  full_name: Riouak, Idriss
  last_name: Riouak
- first_name: Stefano
  full_name: Tonetta, Stefano
  last_name: Tonetta
- first_name: Enea
  full_name: Zaffanella, Enea
  last_name: Zaffanella
citation:
  ama: 'Frehse G, Abate A, Adzkiya D, et al. ARCH-COMP19 Category Report: Hybrid systems
    with piecewise constant dynamics. In: Frehse G, Althoff M, eds. <i>ARCH19. 6th
    International Workshop on Applied Verification of Continuous and Hybrid Systems</i>.
    Vol 61. EasyChair; 2019:1-13. doi:<a href="https://doi.org/10.29007/rjwn">10.29007/rjwn</a>'
  apa: 'Frehse, G., Abate, A., Adzkiya, D., Becchi, A., Bu, L., Cimatti, A., … Zaffanella,
    E. (2019). ARCH-COMP19 Category Report: Hybrid systems with piecewise constant
    dynamics. In G. Frehse &#38; M. Althoff (Eds.), <i>ARCH19. 6th International Workshop
    on Applied Verification of Continuous and Hybrid Systems</i> (Vol. 61, pp. 1–13).
    Montreal, Canada: EasyChair. <a href="https://doi.org/10.29007/rjwn">https://doi.org/10.29007/rjwn</a>'
  chicago: 'Frehse, Goran, Alessandro Abate, Dieky Adzkiya, Anna Becchi, Lei Bu, Alessandro
    Cimatti, Mirco Giacobbe, et al. “ARCH-COMP19 Category Report: Hybrid Systems with
    Piecewise Constant Dynamics.” In <i>ARCH19. 6th International Workshop on Applied
    Verification of Continuous and Hybrid Systems</i>, edited by Goran Frehse and
    Matthias Althoff, 61:1–13. EasyChair, 2019. <a href="https://doi.org/10.29007/rjwn">https://doi.org/10.29007/rjwn</a>.'
  ieee: 'G. Frehse <i>et al.</i>, “ARCH-COMP19 Category Report: Hybrid systems with
    piecewise constant dynamics,” in <i>ARCH19. 6th International Workshop on Applied
    Verification of Continuous and Hybrid Systems</i>, Montreal, Canada, 2019, vol.
    61, pp. 1–13.'
  ista: 'Frehse G, Abate A, Adzkiya D, Becchi A, Bu L, Cimatti A, Giacobbe M, Griggio
    A, Mover S, Mufid MS, Riouak I, Tonetta S, Zaffanella E. 2019. ARCH-COMP19 Category
    Report: Hybrid systems with piecewise constant dynamics. ARCH19. 6th International
    Workshop on Applied Verification of Continuous and Hybrid Systems. ARCH: International
    Workshop on Applied Verification on Continuous and Hybrid Systems, EPiC Series
    in Computing, vol. 61, 1–13.'
  mla: 'Frehse, Goran, et al. “ARCH-COMP19 Category Report: Hybrid Systems with Piecewise
    Constant Dynamics.” <i>ARCH19. 6th International Workshop on Applied Verification
    of Continuous and Hybrid Systems</i>, edited by Goran Frehse and Matthias Althoff,
    vol. 61, EasyChair, 2019, pp. 1–13, doi:<a href="https://doi.org/10.29007/rjwn">10.29007/rjwn</a>.'
  short: G. Frehse, A. Abate, D. Adzkiya, A. Becchi, L. Bu, A. Cimatti, M. Giacobbe,
    A. Griggio, S. Mover, M.S. Mufid, I. Riouak, S. Tonetta, E. Zaffanella, in:, G.
    Frehse, M. Althoff (Eds.), ARCH19. 6th International Workshop on Applied Verification
    of Continuous and Hybrid Systems, EasyChair, 2019, pp. 1–13.
conference:
  end_date: 2019-04-15
  location: Montreal, Canada
  name: 'ARCH: International Workshop on Applied Verification on Continuous and Hybrid
    Systems'
  start_date: 2019-04-15
date_created: 2022-03-18T12:29:23Z
date_published: 2019-05-25T00:00:00Z
date_updated: 2022-05-17T07:09:47Z
day: '25'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.29007/rjwn
editor:
- first_name: Goran
  full_name: Frehse, Goran
  last_name: Frehse
- first_name: Matthias
  full_name: Althoff, Matthias
  last_name: Althoff
file:
- access_level: open_access
  checksum: 4b92e333db7b4e2349501a804dfede69
  content_type: application/pdf
  creator: dernst
  date_created: 2022-05-17T06:55:49Z
  date_updated: 2022-05-17T06:55:49Z
  file_id: '11391'
  file_name: 2019_EPiCs_Frehse.pdf
  file_size: 346415
  relation: main_file
  success: 1
file_date_updated: 2022-05-17T06:55:49Z
has_accepted_license: '1'
intvolume: '        61'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 1-13
publication: ARCH19. 6th International Workshop on Applied Verification of Continuous
  and Hybrid Systems
publication_identifier:
  issn:
  - 2398-7340
publication_status: published
publisher: EasyChair
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'ARCH-COMP19 Category Report: Hybrid systems with piecewise constant dynamics'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 61
year: '2019'
...
---
_id: '10878'
abstract:
- lang: eng
  text: Starting from a microscopic model for a system of neurons evolving in time
    which individually follow a stochastic integrate-and-fire type model, we study
    a mean-field limit of the system. Our model is described by a system of SDEs with
    discontinuous coefficients for the action potential of each neuron and takes into
    account the (random) spatial configuration of neurons allowing the interaction
    to depend on it. In the limit as the number of particles tends to infinity, we
    obtain a nonlinear Fokker-Planck type PDE in two variables, with derivatives only
    with respect to one variable and discontinuous coefficients. We also study strong
    well-posedness of the system of SDEs and prove the existence and uniqueness of
    a weak measure-valued solution to the PDE, obtained as the limit of the laws of
    the empirical measures for the system of particles.
acknowledgement: "The second author has been partially supported by INdAM through
  the GNAMPA Research\r\nProject (2017) “Sistemi stocastici singolari: buona posizione
  e problemi di controllo”. The third\r\nauthor was partly funded by the Austrian
  Science Fund (FWF) project F 65."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Franco
  full_name: Flandoli, Franco
  last_name: Flandoli
- first_name: Enrico
  full_name: Priola, Enrico
  last_name: Priola
- first_name: Giovanni A
  full_name: Zanco, Giovanni A
  id: 47491882-F248-11E8-B48F-1D18A9856A87
  last_name: Zanco
citation:
  ama: Flandoli F, Priola E, Zanco GA. A mean-field model with discontinuous coefficients
    for neurons with spatial interaction. <i>Discrete and Continuous Dynamical Systems</i>.
    2019;39(6):3037-3067. doi:<a href="https://doi.org/10.3934/dcds.2019126">10.3934/dcds.2019126</a>
  apa: Flandoli, F., Priola, E., &#38; Zanco, G. A. (2019). A mean-field model with
    discontinuous coefficients for neurons with spatial interaction. <i>Discrete and
    Continuous Dynamical Systems</i>. American Institute of Mathematical Sciences.
    <a href="https://doi.org/10.3934/dcds.2019126">https://doi.org/10.3934/dcds.2019126</a>
  chicago: Flandoli, Franco, Enrico Priola, and Giovanni A Zanco. “A Mean-Field Model
    with Discontinuous Coefficients for Neurons with Spatial Interaction.” <i>Discrete
    and Continuous Dynamical Systems</i>. American Institute of Mathematical Sciences,
    2019. <a href="https://doi.org/10.3934/dcds.2019126">https://doi.org/10.3934/dcds.2019126</a>.
  ieee: F. Flandoli, E. Priola, and G. A. Zanco, “A mean-field model with discontinuous
    coefficients for neurons with spatial interaction,” <i>Discrete and Continuous
    Dynamical Systems</i>, vol. 39, no. 6. American Institute of Mathematical Sciences,
    pp. 3037–3067, 2019.
  ista: Flandoli F, Priola E, Zanco GA. 2019. A mean-field model with discontinuous
    coefficients for neurons with spatial interaction. Discrete and Continuous Dynamical
    Systems. 39(6), 3037–3067.
  mla: Flandoli, Franco, et al. “A Mean-Field Model with Discontinuous Coefficients
    for Neurons with Spatial Interaction.” <i>Discrete and Continuous Dynamical Systems</i>,
    vol. 39, no. 6, American Institute of Mathematical Sciences, 2019, pp. 3037–67,
    doi:<a href="https://doi.org/10.3934/dcds.2019126">10.3934/dcds.2019126</a>.
  short: F. Flandoli, E. Priola, G.A. Zanco, Discrete and Continuous Dynamical Systems
    39 (2019) 3037–3067.
corr_author: '1'
date_created: 2022-03-18T12:33:34Z
date_published: 2019-06-01T00:00:00Z
date_updated: 2025-04-15T08:31:32Z
day: '01'
department:
- _id: JaMa
doi: 10.3934/dcds.2019126
external_id:
  arxiv:
  - '1708.04156'
  isi:
  - '000459954800003'
intvolume: '        39'
isi: 1
issue: '6'
keyword:
- Applied Mathematics
- Discrete Mathematics and Combinatorics
- Analysis
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1708.04156
month: '06'
oa: 1
oa_version: Preprint
page: 3037-3067
project:
- _id: fc31cba2-9c52-11eb-aca3-ff467d239cd2
  grant_number: F6504
  name: Taming Complexity in Partial Differential Systems
publication: Discrete and Continuous Dynamical Systems
publication_identifier:
  issn:
  - 1553-5231
publication_status: published
publisher: American Institute of Mathematical Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: A mean-field model with discontinuous coefficients for neurons with spatial
  interaction
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 39
year: '2019'
...
---
_id: '10879'
abstract:
- lang: eng
  text: We study effects of a bounded and compactly supported perturbation on multidimensional
    continuum random Schrödinger operators in the region of complete localisation.
    Our main emphasis is on Anderson orthogonality for random Schrödinger operators.
    Among others, we prove that Anderson orthogonality does occur for Fermi energies
    in the region of complete localisation with a non-zero probability. This partially
    confirms recent non-rigorous findings [V. Khemani et al., Nature Phys. 11 (2015),
    560–565]. The spectral shift function plays an important role in our analysis
    of Anderson orthogonality. We identify it with the index of the corresponding
    pair of spectral projections and explore the consequences thereof. All our results
    rely on the main technical estimate of this paper which guarantees separate exponential
    decay of the disorder-averaged Schatten p-norm of χa(f(H)−f(Hτ))χb in a and b.
    Here, Hτ is a perturbation of the random Schrödinger operator H, χa is the multiplication
    operator corresponding to the indicator function of a unit cube centred about
    a∈Rd, and f is in a suitable class of functions of bounded variation with distributional
    derivative supported in the region of complete localisation for H.
acknowledgement: M.G. was supported by the DFG under grant GE 2871/1-1.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Adrian M
  full_name: Dietlein, Adrian M
  id: 317CB464-F248-11E8-B48F-1D18A9856A87
  last_name: Dietlein
- first_name: Martin
  full_name: Gebert, Martin
  last_name: Gebert
- first_name: Peter
  full_name: Müller, Peter
  last_name: Müller
citation:
  ama: Dietlein AM, Gebert M, Müller P. Perturbations of continuum random Schrödinger
    operators with applications to Anderson orthogonality and the spectral shift function.
    <i>Journal of Spectral Theory</i>. 2019;9(3):921-965. doi:<a href="https://doi.org/10.4171/jst/267">10.4171/jst/267</a>
  apa: Dietlein, A. M., Gebert, M., &#38; Müller, P. (2019). Perturbations of continuum
    random Schrödinger operators with applications to Anderson orthogonality and the
    spectral shift function. <i>Journal of Spectral Theory</i>. European Mathematical
    Society. <a href="https://doi.org/10.4171/jst/267">https://doi.org/10.4171/jst/267</a>
  chicago: Dietlein, Adrian M, Martin Gebert, and Peter Müller. “Perturbations of
    Continuum Random Schrödinger Operators with Applications to Anderson Orthogonality
    and the Spectral Shift Function.” <i>Journal of Spectral Theory</i>. European
    Mathematical Society, 2019. <a href="https://doi.org/10.4171/jst/267">https://doi.org/10.4171/jst/267</a>.
  ieee: A. M. Dietlein, M. Gebert, and P. Müller, “Perturbations of continuum random
    Schrödinger operators with applications to Anderson orthogonality and the spectral
    shift function,” <i>Journal of Spectral Theory</i>, vol. 9, no. 3. European Mathematical
    Society, pp. 921–965, 2019.
  ista: Dietlein AM, Gebert M, Müller P. 2019. Perturbations of continuum random Schrödinger
    operators with applications to Anderson orthogonality and the spectral shift function.
    Journal of Spectral Theory. 9(3), 921–965.
  mla: Dietlein, Adrian M., et al. “Perturbations of Continuum Random Schrödinger
    Operators with Applications to Anderson Orthogonality and the Spectral Shift Function.”
    <i>Journal of Spectral Theory</i>, vol. 9, no. 3, European Mathematical Society,
    2019, pp. 921–65, doi:<a href="https://doi.org/10.4171/jst/267">10.4171/jst/267</a>.
  short: A.M. Dietlein, M. Gebert, P. Müller, Journal of Spectral Theory 9 (2019)
    921–965.
date_created: 2022-03-18T12:36:42Z
date_published: 2019-03-01T00:00:00Z
date_updated: 2024-12-11T11:49:15Z
day: '01'
department:
- _id: LaEr
doi: 10.4171/jst/267
external_id:
  arxiv:
  - '1701.02956'
  isi:
  - '000484709400006'
intvolume: '         9'
isi: 1
issue: '3'
keyword:
- Random Schrödinger operators
- spectral shift function
- Anderson orthogonality
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1701.02956
month: '03'
oa: 1
oa_version: Preprint
page: 921-965
publication: Journal of Spectral Theory
publication_identifier:
  issn:
  - 1664-039X
publication_status: published
publisher: European Mathematical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Perturbations of continuum random Schrödinger operators with applications to
  Anderson orthogonality and the spectral shift function
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2019'
...
---
_id: '11059'
abstract:
- lang: eng
  text: The genome is packaged and organized nonrandomly within the 3D space of the
    nucleus to promote efficient gene expression and to faithfully maintain silencing
    of heterochromatin. The genome is enclosed within the nucleus by the nuclear envelope
    membrane, which contains a set of proteins that actively participate in chromatin
    organization and gene regulation. Technological advances are providing views of
    genome organization at unprecedented resolution and are beginning to reveal the
    ways that cells co-opt the structures of the nuclear periphery for nuclear organization
    and gene regulation. These genome regulatory roles of proteins of the nuclear
    periphery have important influences on development, disease and ageing.
article_processing_charge: No
article_type: review
author:
- first_name: Abigail
  full_name: Buchwalter, Abigail
  last_name: Buchwalter
- first_name: Jeanae M.
  full_name: Kaneshiro, Jeanae M.
  last_name: Kaneshiro
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
citation:
  ama: 'Buchwalter A, Kaneshiro JM, Hetzer M. Coaching from the sidelines: The nuclear
    periphery in genome regulation. <i>Nature Reviews Genetics</i>. 2019;20(1):39-50.
    doi:<a href="https://doi.org/10.1038/s41576-018-0063-5">10.1038/s41576-018-0063-5</a>'
  apa: 'Buchwalter, A., Kaneshiro, J. M., &#38; Hetzer, M. (2019). Coaching from the
    sidelines: The nuclear periphery in genome regulation. <i>Nature Reviews Genetics</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41576-018-0063-5">https://doi.org/10.1038/s41576-018-0063-5</a>'
  chicago: 'Buchwalter, Abigail, Jeanae M. Kaneshiro, and Martin Hetzer. “Coaching
    from the Sidelines: The Nuclear Periphery in Genome Regulation.” <i>Nature Reviews
    Genetics</i>. Springer Nature, 2019. <a href="https://doi.org/10.1038/s41576-018-0063-5">https://doi.org/10.1038/s41576-018-0063-5</a>.'
  ieee: 'A. Buchwalter, J. M. Kaneshiro, and M. Hetzer, “Coaching from the sidelines:
    The nuclear periphery in genome regulation,” <i>Nature Reviews Genetics</i>, vol.
    20, no. 1. Springer Nature, pp. 39–50, 2019.'
  ista: 'Buchwalter A, Kaneshiro JM, Hetzer M. 2019. Coaching from the sidelines:
    The nuclear periphery in genome regulation. Nature Reviews Genetics. 20(1), 39–50.'
  mla: 'Buchwalter, Abigail, et al. “Coaching from the Sidelines: The Nuclear Periphery
    in Genome Regulation.” <i>Nature Reviews Genetics</i>, vol. 20, no. 1, Springer
    Nature, 2019, pp. 39–50, doi:<a href="https://doi.org/10.1038/s41576-018-0063-5">10.1038/s41576-018-0063-5</a>.'
  short: A. Buchwalter, J.M. Kaneshiro, M. Hetzer, Nature Reviews Genetics 20 (2019)
    39–50.
date_created: 2022-04-07T07:44:45Z
date_published: 2019-01-01T00:00:00Z
date_updated: 2024-10-14T11:18:54Z
day: '01'
doi: 10.1038/s41576-018-0063-5
extern: '1'
external_id:
  pmid:
  - '30356165'
intvolume: '        20'
issue: '1'
keyword:
- Genetics (clinical)
- Genetics
- Molecular Biology
language:
- iso: eng
month: '01'
oa_version: None
page: 39-50
pmid: 1
publication: Nature Reviews Genetics
publication_identifier:
  eissn:
  - 1471-0064
  issn:
  - 1471-0056
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Coaching from the sidelines: The nuclear periphery in genome regulation'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '2019'
...
---
_id: '11060'
abstract:
- lang: eng
  text: The inner nuclear membrane (INM) is a subdomain of the endoplasmic reticulum
    (ER) that is gated by the nuclear pore complex. It is unknown whether proteins
    of the INM and ER are degraded through shared or distinct pathways in mammalian
    cells. We applied dynamic proteomics to profile protein half-lives and report
    that INM and ER residents turn over at similar rates, indicating that the INM’s
    unique topology is not a barrier to turnover. Using a microscopy approach, we
    observed that the proteasome can degrade INM proteins in situ. However, we also
    uncovered evidence for selective, vesicular transport-mediated turnover of a single
    INM protein, emerin, that is potentiated by ER stress. Emerin is rapidly cleared
    from the INM by a mechanism that requires emerin’s LEM domain to mediate vesicular
    trafficking to lysosomes. This work demonstrates that the INM can be dynamically
    remodeled in response to environmental inputs.
article_number: e49796
article_processing_charge: No
article_type: original
author:
- first_name: Abigail
  full_name: Buchwalter, Abigail
  last_name: Buchwalter
- first_name: Roberta
  full_name: Schulte, Roberta
  last_name: Schulte
- first_name: Hsiao
  full_name: Tsai, Hsiao
  last_name: Tsai
- first_name: Juliana
  full_name: Capitanio, Juliana
  last_name: Capitanio
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
citation:
  ama: Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. Selective clearance
    of the inner nuclear membrane protein emerin by vesicular transport during ER
    stress. <i>eLife</i>. 2019;8. doi:<a href="https://doi.org/10.7554/elife.49796">10.7554/elife.49796</a>
  apa: Buchwalter, A., Schulte, R., Tsai, H., Capitanio, J., &#38; Hetzer, M. (2019).
    Selective clearance of the inner nuclear membrane protein emerin by vesicular
    transport during ER stress. <i>ELife</i>. eLife Sciences Publications. <a href="https://doi.org/10.7554/elife.49796">https://doi.org/10.7554/elife.49796</a>
  chicago: Buchwalter, Abigail, Roberta Schulte, Hsiao Tsai, Juliana Capitanio, and
    Martin Hetzer. “Selective Clearance of the Inner Nuclear Membrane Protein Emerin
    by Vesicular Transport during ER Stress.” <i>ELife</i>. eLife Sciences Publications,
    2019. <a href="https://doi.org/10.7554/elife.49796">https://doi.org/10.7554/elife.49796</a>.
  ieee: A. Buchwalter, R. Schulte, H. Tsai, J. Capitanio, and M. Hetzer, “Selective
    clearance of the inner nuclear membrane protein emerin by vesicular transport
    during ER stress,” <i>eLife</i>, vol. 8. eLife Sciences Publications, 2019.
  ista: Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. 2019. Selective clearance
    of the inner nuclear membrane protein emerin by vesicular transport during ER
    stress. eLife. 8, e49796.
  mla: Buchwalter, Abigail, et al. “Selective Clearance of the Inner Nuclear Membrane
    Protein Emerin by Vesicular Transport during ER Stress.” <i>ELife</i>, vol. 8,
    e49796, eLife Sciences Publications, 2019, doi:<a href="https://doi.org/10.7554/elife.49796">10.7554/elife.49796</a>.
  short: A. Buchwalter, R. Schulte, H. Tsai, J. Capitanio, M. Hetzer, ELife 8 (2019).
date_created: 2022-04-07T07:45:02Z
date_published: 2019-10-10T00:00:00Z
date_updated: 2024-10-14T12:08:36Z
day: '10'
ddc:
- '570'
doi: 10.7554/elife.49796
extern: '1'
external_id:
  pmid:
  - '31599721'
file:
- access_level: open_access
  checksum: 1e8672a1e9c3dc0a2d3d0dad89673616
  content_type: application/pdf
  creator: dernst
  date_created: 2022-04-08T08:18:01Z
  date_updated: 2022-04-08T08:18:01Z
  file_id: '11138'
  file_name: 2019_eLife_Buchwalter.pdf
  file_size: 6984654
  relation: main_file
  success: 1
file_date_updated: 2022-04-08T08:18:01Z
has_accepted_license: '1'
intvolume: '         8'
keyword:
- General Immunology and Microbiology
- General Biochemistry
- Genetics and Molecular Biology
- General Medicine
- General Neuroscience
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
publication: eLife
publication_identifier:
  issn:
  - 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
related_material:
  record:
  - id: '13079'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Selective clearance of the inner nuclear membrane protein emerin by vesicular
  transport during ER stress
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2019'
...
---
_id: '11061'
abstract:
- lang: eng
  text: Many adult tissues contain postmitotic cells as old as the host organism.
    The only organelle that does not turn over in these cells is the nucleus, and
    its maintenance represents a formidable challenge, as it harbors regulatory proteins
    that persist throughout adulthood. Here we developed strategies to visualize two
    classes of such long-lived proteins, histones and nucleoporins, to understand
    the function of protein longevity in nuclear maintenance. Genome-wide mapping
    of histones revealed specific enrichment of long-lived variants at silent gene
    loci. Interestingly, nuclear pores are maintained by piecemeal replacement of
    subunits, resulting in mosaic complexes composed of polypeptides with vastly different
    ages. In contrast, nondividing quiescent cells remove old nuclear pores in an
    ESCRT-dependent manner. Our findings reveal distinct molecular strategies of nuclear
    maintenance, linking lifelong protein persistence to gene regulation and nuclear
    integrity.
article_processing_charge: No
article_type: original
author:
- first_name: Brandon H.
  full_name: Toyama, Brandon H.
  last_name: Toyama
- first_name: Rafael
  full_name: Arrojo e Drigo, Rafael
  last_name: Arrojo e Drigo
- first_name: Varda
  full_name: Lev-Ram, Varda
  last_name: Lev-Ram
- first_name: Ranjan
  full_name: Ramachandra, Ranjan
  last_name: Ramachandra
- first_name: Thomas J.
  full_name: Deerinck, Thomas J.
  last_name: Deerinck
- first_name: Claude
  full_name: Lechene, Claude
  last_name: Lechene
- first_name: Mark H.
  full_name: Ellisman, Mark H.
  last_name: Ellisman
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
citation:
  ama: Toyama BH, Arrojo e Drigo R, Lev-Ram V, et al. Visualization of long-lived
    proteins reveals age mosaicism within nuclei of postmitotic cells. <i>Journal
    of Cell Biology</i>. 2019;218(2):433-444. doi:<a href="https://doi.org/10.1083/jcb.201809123">10.1083/jcb.201809123</a>
  apa: Toyama, B. H., Arrojo e Drigo, R., Lev-Ram, V., Ramachandra, R., Deerinck,
    T. J., Lechene, C., … Hetzer, M. (2019). Visualization of long-lived proteins
    reveals age mosaicism within nuclei of postmitotic cells. <i>Journal of Cell Biology</i>.
    Rockefeller University Press. <a href="https://doi.org/10.1083/jcb.201809123">https://doi.org/10.1083/jcb.201809123</a>
  chicago: Toyama, Brandon H., Rafael Arrojo e Drigo, Varda Lev-Ram, Ranjan Ramachandra,
    Thomas J. Deerinck, Claude Lechene, Mark H. Ellisman, and Martin Hetzer. “Visualization
    of Long-Lived Proteins Reveals Age Mosaicism within Nuclei of Postmitotic Cells.”
    <i>Journal of Cell Biology</i>. Rockefeller University Press, 2019. <a href="https://doi.org/10.1083/jcb.201809123">https://doi.org/10.1083/jcb.201809123</a>.
  ieee: B. H. Toyama <i>et al.</i>, “Visualization of long-lived proteins reveals
    age mosaicism within nuclei of postmitotic cells,” <i>Journal of Cell Biology</i>,
    vol. 218, no. 2. Rockefeller University Press, pp. 433–444, 2019.
  ista: Toyama BH, Arrojo e Drigo R, Lev-Ram V, Ramachandra R, Deerinck TJ, Lechene
    C, Ellisman MH, Hetzer M. 2019. Visualization of long-lived proteins reveals age
    mosaicism within nuclei of postmitotic cells. Journal of Cell Biology. 218(2),
    433–444.
  mla: Toyama, Brandon H., et al. “Visualization of Long-Lived Proteins Reveals Age
    Mosaicism within Nuclei of Postmitotic Cells.” <i>Journal of Cell Biology</i>,
    vol. 218, no. 2, Rockefeller University Press, 2019, pp. 433–44, doi:<a href="https://doi.org/10.1083/jcb.201809123">10.1083/jcb.201809123</a>.
  short: B.H. Toyama, R. Arrojo e Drigo, V. Lev-Ram, R. Ramachandra, T.J. Deerinck,
    C. Lechene, M.H. Ellisman, M. Hetzer, Journal of Cell Biology 218 (2019) 433–444.
date_created: 2022-04-07T07:45:11Z
date_published: 2019-02-04T00:00:00Z
date_updated: 2024-10-14T11:19:21Z
day: '04'
ddc:
- '570'
doi: 10.1083/jcb.201809123
extern: '1'
external_id:
  pmid:
  - '30552100'
file:
- access_level: open_access
  checksum: 7964ebbf833b0b35f9fba840eea9531d
  content_type: application/pdf
  creator: dernst
  date_created: 2022-04-08T08:26:32Z
  date_updated: 2022-04-08T08:26:32Z
  file_id: '11139'
  file_name: 2019_JCB_Toyama.pdf
  file_size: 2503838
  relation: main_file
  success: 1
file_date_updated: 2022-04-08T08:26:32Z
has_accepted_license: '1'
intvolume: '       218'
issue: '2'
keyword:
- Cell Biology
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '02'
oa: 1
oa_version: Published Version
page: 433-444
pmid: 1
publication: Journal of Cell Biology
publication_identifier:
  eissn:
  - 1540-8140
  issn:
  - 0021-9525
publication_status: published
publisher: Rockefeller University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Visualization of long-lived proteins reveals age mosaicism within nuclei of
  postmitotic cells
tmp:
  image: /images/cc_by_nc_sa.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
    BY-NC-SA 4.0)
  short: CC BY-NC-SA (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 218
year: '2019'
...
---
_id: '11062'
abstract:
- lang: eng
  text: Most neurons are not replaced during an animal’s lifetime. This nondividing
    state is characterized by extreme longevity and age-dependent decline of key regulatory
    proteins. To study the lifespans of cells and proteins in adult tissues, we combined
    isotope labeling of mice with a hybrid imaging method (MIMS-EM). Using 15N mapping,
    we show that liver and pancreas are composed of cells with vastly different ages,
    many as old as the animal. Strikingly, we also found that a subset of fibroblasts
    and endothelial cells, both known for their replicative potential, are characterized
    by the absence of cell division during adulthood. In addition, we show that the
    primary cilia of beta cells and neurons contains different structural regions
    with vastly different lifespans. Based on these results, we propose that age mosaicism
    across multiple scales is a fundamental principle of adult tissue, cell, and protein
    complex organization.
article_processing_charge: No
article_type: original
author:
- first_name: Rafael
  full_name: Arrojo e Drigo, Rafael
  last_name: Arrojo e Drigo
- first_name: Varda
  full_name: Lev-Ram, Varda
  last_name: Lev-Ram
- first_name: Swati
  full_name: Tyagi, Swati
  last_name: Tyagi
- first_name: Ranjan
  full_name: Ramachandra, Ranjan
  last_name: Ramachandra
- first_name: Thomas
  full_name: Deerinck, Thomas
  last_name: Deerinck
- first_name: Eric
  full_name: Bushong, Eric
  last_name: Bushong
- first_name: Sebastien
  full_name: Phan, Sebastien
  last_name: Phan
- first_name: Victoria
  full_name: Orphan, Victoria
  last_name: Orphan
- first_name: Claude
  full_name: Lechene, Claude
  last_name: Lechene
- first_name: Mark H.
  full_name: Ellisman, Mark H.
  last_name: Ellisman
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
citation:
  ama: Arrojo e Drigo R, Lev-Ram V, Tyagi S, et al. Age mosaicism across multiple
    scales in adult tissues. <i>Cell Metabolism</i>. 2019;30(2):343-351.e3. doi:<a
    href="https://doi.org/10.1016/j.cmet.2019.05.010">10.1016/j.cmet.2019.05.010</a>
  apa: Arrojo e Drigo, R., Lev-Ram, V., Tyagi, S., Ramachandra, R., Deerinck, T.,
    Bushong, E., … Hetzer, M. (2019). Age mosaicism across multiple scales in adult
    tissues. <i>Cell Metabolism</i>. Elsevier. <a href="https://doi.org/10.1016/j.cmet.2019.05.010">https://doi.org/10.1016/j.cmet.2019.05.010</a>
  chicago: Arrojo e Drigo, Rafael, Varda Lev-Ram, Swati Tyagi, Ranjan Ramachandra,
    Thomas Deerinck, Eric Bushong, Sebastien Phan, et al. “Age Mosaicism across Multiple
    Scales in Adult Tissues.” <i>Cell Metabolism</i>. Elsevier, 2019. <a href="https://doi.org/10.1016/j.cmet.2019.05.010">https://doi.org/10.1016/j.cmet.2019.05.010</a>.
  ieee: R. Arrojo e Drigo <i>et al.</i>, “Age mosaicism across multiple scales in
    adult tissues,” <i>Cell Metabolism</i>, vol. 30, no. 2. Elsevier, p. 343–351.e3,
    2019.
  ista: Arrojo e Drigo R, Lev-Ram V, Tyagi S, Ramachandra R, Deerinck T, Bushong E,
    Phan S, Orphan V, Lechene C, Ellisman MH, Hetzer M. 2019. Age mosaicism across
    multiple scales in adult tissues. Cell Metabolism. 30(2), 343–351.e3.
  mla: Arrojo e Drigo, Rafael, et al. “Age Mosaicism across Multiple Scales in Adult
    Tissues.” <i>Cell Metabolism</i>, vol. 30, no. 2, Elsevier, 2019, p. 343–351.e3,
    doi:<a href="https://doi.org/10.1016/j.cmet.2019.05.010">10.1016/j.cmet.2019.05.010</a>.
  short: R. Arrojo e Drigo, V. Lev-Ram, S. Tyagi, R. Ramachandra, T. Deerinck, E.
    Bushong, S. Phan, V. Orphan, C. Lechene, M.H. Ellisman, M. Hetzer, Cell Metabolism
    30 (2019) 343–351.e3.
date_created: 2022-04-07T07:45:21Z
date_published: 2019-08-06T00:00:00Z
date_updated: 2025-12-15T10:02:11Z
day: '06'
department:
- _id: MaHe
doi: 10.1016/j.cmet.2019.05.010
extern: '1'
external_id:
  pmid:
  - '31178361'
intvolume: '        30'
issue: '2'
keyword:
- Cell Biology
- Molecular Biology
- Physiology
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.cmet.2019.05.010
month: '08'
oa: 1
oa_version: Published Version
page: 343-351.e3
pmid: 1
publication: Cell Metabolism
publication_identifier:
  issn:
  - 1550-4131
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Age mosaicism across multiple scales in adult tissues
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 30
year: '2019'
...
---
OA_place: publisher
OA_type: hybrid
_id: '10190'
abstract:
- lang: eng
  text: 'The verification of concurrent programs remains an open challenge, as thread
    interaction has to be accounted for, which leads to state-space explosion. Stateless
    model checking battles this problem by exploring traces rather than states of
    the program. As there are exponentially many traces, dynamic partial-order reduction
    (DPOR) techniques are used to partition the trace space into equivalence classes,
    and explore a few representatives from each class. The standard equivalence that
    underlies most DPOR techniques is the happens-before equivalence, however recent
    works have spawned a vivid interest towards coarser equivalences. The efficiency
    of such approaches is a product of two parameters: (i) the size of the partitioning
    induced by the equivalence, and (ii) the time spent by the exploration algorithm
    in each class of the partitioning. In this work, we present a new equivalence,
    called value-happens-before and show that it has two appealing features. First,
    value-happens-before is always at least as coarse as the happens-before equivalence,
    and can be even exponentially coarser. Second, the value-happens-before partitioning
    is efficiently explorable when the number of threads is bounded. We present an
    algorithm called value-centric DPOR (VCDPOR), which explores the underlying partitioning
    using polynomial time per class. Finally, we perform an experimental evaluation
    of VCDPOR on various benchmarks, and compare it against other state-of-the-art
    approaches. Our results show that value-happens-before typically induces a significant
    reduction in the size of the underlying partitioning, which leads to a considerable
    reduction in the running time for exploring the whole partitioning.'
acknowledgement: "The authors would also like to thank anonymous referees for their
  valuable comments and helpful suggestions. This work is supported by the Austrian
  Science Fund (FWF) NFN grants S11407-N23 (RiSE/SHiNE) and S11402-N23 (RiSE/SHiNE),
  by the Vienna Science and Technology Fund (WWTF) Project ICT15-003, and by the Austrian
  Science Fund (FWF) Schrodinger grant J-4220.\r\n"
article_number: '124'
article_processing_charge: No
arxiv: 1
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Andreas
  full_name: Pavlogiannis, Andreas
  id: 49704004-F248-11E8-B48F-1D18A9856A87
  last_name: Pavlogiannis
  orcid: 0000-0002-8943-0722
- first_name: Viktor
  full_name: Toman, Viktor
  id: 3AF3DA7C-F248-11E8-B48F-1D18A9856A87
  last_name: Toman
  orcid: 0000-0001-9036-063X
citation:
  ama: 'Chatterjee K, Pavlogiannis A, Toman V. Value-centric dynamic partial order
    reduction. In: <i>Proceedings of the 34th ACM International Conference on Object-Oriented
    Programming, Systems, Languages, and Applications</i>. Vol 3. ACM; 2019. doi:<a
    href="https://doi.org/10.1145/3360550">10.1145/3360550</a>'
  apa: 'Chatterjee, K., Pavlogiannis, A., &#38; Toman, V. (2019). Value-centric dynamic
    partial order reduction. In <i>Proceedings of the 34th ACM International Conference
    on Object-Oriented Programming, Systems, Languages, and Applications</i> (Vol.
    3). Athens, Greece: ACM. <a href="https://doi.org/10.1145/3360550">https://doi.org/10.1145/3360550</a>'
  chicago: Chatterjee, Krishnendu, Andreas Pavlogiannis, and Viktor Toman. “Value-Centric
    Dynamic Partial Order Reduction.” In <i>Proceedings of the 34th ACM International
    Conference on Object-Oriented Programming, Systems, Languages, and Applications</i>,
    Vol. 3. ACM, 2019. <a href="https://doi.org/10.1145/3360550">https://doi.org/10.1145/3360550</a>.
  ieee: K. Chatterjee, A. Pavlogiannis, and V. Toman, “Value-centric dynamic partial
    order reduction,” in <i>Proceedings of the 34th ACM International Conference on
    Object-Oriented Programming, Systems, Languages, and Applications</i>, Athens,
    Greece, 2019, vol. 3.
  ista: 'Chatterjee K, Pavlogiannis A, Toman V. 2019. Value-centric dynamic partial
    order reduction. Proceedings of the 34th ACM International Conference on Object-Oriented
    Programming, Systems, Languages, and Applications. OOPSLA: Object-oriented Programming,
    Systems, Languages and Applications vol. 3, 124.'
  mla: Chatterjee, Krishnendu, et al. “Value-Centric Dynamic Partial Order Reduction.”
    <i>Proceedings of the 34th ACM International Conference on Object-Oriented Programming,
    Systems, Languages, and Applications</i>, vol. 3, 124, ACM, 2019, doi:<a href="https://doi.org/10.1145/3360550">10.1145/3360550</a>.
  short: K. Chatterjee, A. Pavlogiannis, V. Toman, in:, Proceedings of the 34th ACM
    International Conference on Object-Oriented Programming, Systems, Languages, and
    Applications, ACM, 2019.
conference:
  end_date: 2019-10-25
  location: Athens, Greece
  name: 'OOPSLA: Object-oriented Programming, Systems, Languages and Applications'
  start_date: 2019-10-23
corr_author: '1'
date_created: 2021-10-27T14:57:06Z
date_published: 2019-10-10T00:00:00Z
date_updated: 2025-05-20T09:38:25Z
day: '10'
ddc:
- '000'
department:
- _id: GradSch
- _id: KrCh
doi: 10.1145/3360550
external_id:
  arxiv:
  - '1909.00989'
file:
- access_level: open_access
  checksum: 2149979c46964c4d117af06ccb6c0834
  content_type: application/pdf
  creator: cchlebak
  date_created: 2021-11-12T11:41:56Z
  date_updated: 2021-11-12T11:41:56Z
  file_id: '10278'
  file_name: 2019_ACM_Chatterjee.pdf
  file_size: 570829
  relation: main_file
  success: 1
file_date_updated: 2021-11-12T11:41:56Z
has_accepted_license: '1'
intvolume: '         3'
keyword:
- safety
- risk
- reliability and quality
- software
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 25892FC0-B435-11E9-9278-68D0E5697425
  grant_number: ICT15-003
  name: Efficient Algorithms for Computer Aided Verification
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S11407
  name: Game Theory
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 25F5A88A-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S11402-N23
  name: Moderne Concurrency Paradigms
publication: Proceedings of the 34th ACM International Conference on Object-Oriented
  Programming, Systems, Languages, and Applications
publication_identifier:
  eissn:
  - 2475-1421
publication_status: published
publisher: ACM
quality_controlled: '1'
related_material:
  record:
  - id: '10199'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Value-centric dynamic partial order reduction
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2019'
...
---
_id: '10354'
abstract:
- lang: eng
  text: "Background\r\nESCRT-III is a membrane remodelling filament with the unique
    ability to cut membranes from the inside of the membrane neck. It is essential
    for the final stage of cell division, the formation of vesicles, the release of
    viruses, and membrane repair. Distinct from other cytoskeletal filaments, ESCRT-III
    filaments do not consume energy themselves, but work in conjunction with another
    ATP-consuming complex. Despite rapid progress in describing the cell biology of
    ESCRT-III, we lack an understanding of the physical mechanisms behind its force
    production and membrane remodelling.\r\nResults\r\nHere we present a minimal coarse-grained
    model that captures all the experimentally reported cases of ESCRT-III driven
    membrane sculpting, including the formation of downward and upward cones and tubules.
    This model suggests that a change in the geometry of membrane bound ESCRT-III
    filaments—from a flat spiral to a 3D helix—drives membrane deformation. We then
    show that such repetitive filament geometry transitions can induce the fission
    of cargo-containing vesicles.\r\nConclusions\r\nOur model provides a general physical
    mechanism that explains the full range of ESCRT-III-dependent membrane remodelling
    and scission events observed in cells. This mechanism for filament force production
    is distinct from the mechanisms described for other cytoskeletal elements discovered
    so far. The mechanistic principles revealed here suggest new ways of manipulating
    ESCRT-III-driven processes in cells and could be used to guide the engineering
    of synthetic membrane-sculpting systems."
acknowledgement: We thank Jeremy Carlton, Mike Staddon, Geraint Harker, and the Wellcome
  Trust Consortium “Archaeal Origins of Eukaryotic Cell Organisation” for fruitful
  conversations. We thank Peter Wirnsberger and Tine Curk for discussions about the
  membrane model implementation.
article_number: '82'
article_processing_charge: No
article_type: original
author:
- first_name: Lena
  full_name: Harker-Kirschneck, Lena
  last_name: Harker-Kirschneck
- first_name: Buzz
  full_name: Baum, Buzz
  last_name: Baum
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
citation:
  ama: Harker-Kirschneck L, Baum B, Šarić A. Changes in ESCRT-III filament geometry
    drive membrane remodelling and fission in silico. <i>BMC Biology</i>. 2019;17(1).
    doi:<a href="https://doi.org/10.1186/s12915-019-0700-2">10.1186/s12915-019-0700-2</a>
  apa: Harker-Kirschneck, L., Baum, B., &#38; Šarić, A. (2019). Changes in ESCRT-III
    filament geometry drive membrane remodelling and fission in silico. <i>BMC Biology</i>.
    Springer Nature. <a href="https://doi.org/10.1186/s12915-019-0700-2">https://doi.org/10.1186/s12915-019-0700-2</a>
  chicago: Harker-Kirschneck, Lena, Buzz Baum, and Anđela Šarić. “Changes in ESCRT-III
    Filament Geometry Drive Membrane Remodelling and Fission in Silico.” <i>BMC Biology</i>.
    Springer Nature, 2019. <a href="https://doi.org/10.1186/s12915-019-0700-2">https://doi.org/10.1186/s12915-019-0700-2</a>.
  ieee: L. Harker-Kirschneck, B. Baum, and A. Šarić, “Changes in ESCRT-III filament
    geometry drive membrane remodelling and fission in silico,” <i>BMC Biology</i>,
    vol. 17, no. 1. Springer Nature, 2019.
  ista: Harker-Kirschneck L, Baum B, Šarić A. 2019. Changes in ESCRT-III filament
    geometry drive membrane remodelling and fission in silico. BMC Biology. 17(1),
    82.
  mla: Harker-Kirschneck, Lena, et al. “Changes in ESCRT-III Filament Geometry Drive
    Membrane Remodelling and Fission in Silico.” <i>BMC Biology</i>, vol. 17, no.
    1, 82, Springer Nature, 2019, doi:<a href="https://doi.org/10.1186/s12915-019-0700-2">10.1186/s12915-019-0700-2</a>.
  short: L. Harker-Kirschneck, B. Baum, A. Šarić, BMC Biology 17 (2019).
date_created: 2021-11-26T11:25:03Z
date_published: 2019-10-22T00:00:00Z
date_updated: 2021-11-26T11:54:29Z
day: '22'
ddc:
- '570'
doi: 10.1186/s12915-019-0700-2
extern: '1'
external_id:
  pmid:
  - '31640700'
file:
- access_level: open_access
  checksum: 31d8bae55a376d30925f53f7e1a02396
  content_type: application/pdf
  creator: cchlebak
  date_created: 2021-11-26T11:37:54Z
  date_updated: 2021-11-26T11:37:54Z
  file_id: '10356'
  file_name: 2019_BMCBio_Harker_Kirschneck.pdf
  file_size: 1648926
  relation: main_file
  success: 1
file_date_updated: 2021-11-26T11:37:54Z
has_accepted_license: '1'
intvolume: '        17'
issue: '1'
keyword:
- cell biology
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.biorxiv.org/content/10.1101/559898
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
publication: BMC Biology
publication_identifier:
  issn:
  - 1741-7007
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Changes in ESCRT-III filament geometry drive membrane remodelling and fission
  in silico
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 17
year: '2019'
...
---
_id: '10355'
abstract:
- lang: eng
  text: The molecular machinery of life is largely created via self-organisation of
    individual molecules into functional assemblies. Minimal coarse-grained models,
    in which a whole macromolecule is represented by a small number of particles,
    can be of great value in identifying the main driving forces behind self-organisation
    in cell biology. Such models can incorporate data from both molecular and continuum
    scales, and their results can be directly compared to experiments. Here we review
    the state of the art of models for studying the formation and biological function
    of macromolecular assemblies in living organisms. We outline the key ingredients
    of each model and their main findings. We illustrate the contribution of this
    class of simulations to identifying the physical mechanisms behind life and diseases,
    and discuss their future developments.
acknowledgement: We acknowledge funding from EPSRC (A.E.H. and A.Š.), the Academy
  of Medical Sciences (J.K. and A.Š.), the Wellcome Trust (J.K. and A.Š.), and the
  Royal Society (A.Š.). We thank Shiladitya Banerjee and Nikola Ojkic for critically
  reading the manuscript, and Claudia Flandoli for helping us with figures and illustrations.
article_processing_charge: No
article_type: original
author:
- first_name: Anne E
  full_name: Hafner, Anne E
  last_name: Hafner
- first_name: Johannes
  full_name: Krausser, Johannes
  last_name: Krausser
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
citation:
  ama: Hafner AE, Krausser J, Šarić A. Minimal coarse-grained models for molecular
    self-organisation in biology. <i>Current Opinion in Structural Biology</i>. 2019;58:43-52.
    doi:<a href="https://doi.org/10.1016/j.sbi.2019.05.018">10.1016/j.sbi.2019.05.018</a>
  apa: Hafner, A. E., Krausser, J., &#38; Šarić, A. (2019). Minimal coarse-grained
    models for molecular self-organisation in biology. <i>Current Opinion in Structural
    Biology</i>. Elsevier. <a href="https://doi.org/10.1016/j.sbi.2019.05.018">https://doi.org/10.1016/j.sbi.2019.05.018</a>
  chicago: Hafner, Anne E, Johannes Krausser, and Anđela Šarić. “Minimal Coarse-Grained
    Models for Molecular Self-Organisation in Biology.” <i>Current Opinion in Structural
    Biology</i>. Elsevier, 2019. <a href="https://doi.org/10.1016/j.sbi.2019.05.018">https://doi.org/10.1016/j.sbi.2019.05.018</a>.
  ieee: A. E. Hafner, J. Krausser, and A. Šarić, “Minimal coarse-grained models for
    molecular self-organisation in biology,” <i>Current Opinion in Structural Biology</i>,
    vol. 58. Elsevier, pp. 43–52, 2019.
  ista: Hafner AE, Krausser J, Šarić A. 2019. Minimal coarse-grained models for molecular
    self-organisation in biology. Current Opinion in Structural Biology. 58, 43–52.
  mla: Hafner, Anne E., et al. “Minimal Coarse-Grained Models for Molecular Self-Organisation
    in Biology.” <i>Current Opinion in Structural Biology</i>, vol. 58, Elsevier,
    2019, pp. 43–52, doi:<a href="https://doi.org/10.1016/j.sbi.2019.05.018">10.1016/j.sbi.2019.05.018</a>.
  short: A.E. Hafner, J. Krausser, A. Šarić, Current Opinion in Structural Biology
    58 (2019) 43–52.
date_created: 2021-11-26T11:33:21Z
date_published: 2019-06-18T00:00:00Z
date_updated: 2021-11-26T11:54:25Z
day: '18'
doi: 10.1016/j.sbi.2019.05.018
extern: '1'
external_id:
  pmid:
  - '31226513'
intvolume: '        58'
keyword:
- molecular biology
- structural biology
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1906.09349
month: '06'
oa: 1
oa_version: Preprint
page: 43-52
pmid: 1
publication: Current Opinion in Structural Biology
publication_identifier:
  issn:
  - 0959-440X
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Minimal coarse-grained models for molecular self-organisation in biology
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 58
year: '2019'
...
---
_id: '105'
abstract:
- lang: eng
  text: 'Clinical Utility Gene Card. 1. Name of Disease (Synonyms): Pontocerebellar
    hypoplasia type 9 (PCH9) and spastic paraplegia-63 (SPG63). 2. OMIM# of the Disease:
    615809 and 615686. 3. Name of the Analysed Genes or DNA/Chromosome Segments: AMPD2
    at 1p13.3. 4. OMIM# of the Gene(s): 102771.'
acknowledgement: 'This work was supported by EuroGentest2 (Unit 2: “Genetic testing
  as part of health care”), a Coordination Action under FP7 (Grant Agreement Number
  261469) and the European Society of Human Genetics. We acknowledge the participation
  of the patients and their families in these studies, as well as the generous financial
  support of the Lefroy and Handbury families. APLM was supported by an Australian
  Postgraduate Award. PJL is supported by an NHMRC Career Development Fellowship (GNT1032364).
  RJL is supported by a Melbourne Children’s Clinician Scientist Fellowship.'
article_processing_charge: No
article_type: original
author:
- first_name: Ashley
  full_name: Marsh, Ashley
  last_name: Marsh
- first_name: Gaia
  full_name: Novarino, Gaia
  id: 3E57A680-F248-11E8-B48F-1D18A9856A87
  last_name: Novarino
  orcid: 0000-0002-7673-7178
- first_name: Paul
  full_name: Lockhart, Paul
  last_name: Lockhart
- first_name: Richard
  full_name: Leventer, Richard
  last_name: Leventer
citation:
  ama: Marsh A, Novarino G, Lockhart P, Leventer R. CUGC for pontocerebellar hypoplasia
    type 9 and spastic paraplegia-63. <i>European Journal of Human Genetics</i>. 2019;27:161-166.
    doi:<a href="https://doi.org/10.1038/s41431-018-0231-2">10.1038/s41431-018-0231-2</a>
  apa: Marsh, A., Novarino, G., Lockhart, P., &#38; Leventer, R. (2019). CUGC for
    pontocerebellar hypoplasia type 9 and spastic paraplegia-63. <i>European Journal
    of Human Genetics</i>. Springer Nature. <a href="https://doi.org/10.1038/s41431-018-0231-2">https://doi.org/10.1038/s41431-018-0231-2</a>
  chicago: Marsh, Ashley, Gaia Novarino, Paul Lockhart, and Richard Leventer. “CUGC
    for Pontocerebellar Hypoplasia Type 9 and Spastic Paraplegia-63.” <i>European
    Journal of Human Genetics</i>. Springer Nature, 2019. <a href="https://doi.org/10.1038/s41431-018-0231-2">https://doi.org/10.1038/s41431-018-0231-2</a>.
  ieee: A. Marsh, G. Novarino, P. Lockhart, and R. Leventer, “CUGC for pontocerebellar
    hypoplasia type 9 and spastic paraplegia-63,” <i>European Journal of Human Genetics</i>,
    vol. 27. Springer Nature, pp. 161–166, 2019.
  ista: Marsh A, Novarino G, Lockhart P, Leventer R. 2019. CUGC for pontocerebellar
    hypoplasia type 9 and spastic paraplegia-63. European Journal of Human Genetics.
    27, 161–166.
  mla: Marsh, Ashley, et al. “CUGC for Pontocerebellar Hypoplasia Type 9 and Spastic
    Paraplegia-63.” <i>European Journal of Human Genetics</i>, vol. 27, Springer Nature,
    2019, pp. 161–66, doi:<a href="https://doi.org/10.1038/s41431-018-0231-2">10.1038/s41431-018-0231-2</a>.
  short: A. Marsh, G. Novarino, P. Lockhart, R. Leventer, European Journal of Human
    Genetics 27 (2019) 161–166.
date_created: 2018-12-11T11:44:39Z
date_published: 2019-01-01T00:00:00Z
date_updated: 2023-08-24T14:28:24Z
day: '01'
department:
- _id: GaNo
doi: 10.1038/s41431-018-0231-2
external_id:
  isi:
  - '000454111500019'
  pmid:
  - '30089829'
intvolume: '        27'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1038/s41431-018-0231-2
month: '01'
oa: 1
oa_version: Published Version
page: 161-166
pmid: 1
publication: European Journal of Human Genetics
publication_status: published
publisher: Springer Nature
publist_id: '7949'
quality_controlled: '1'
scopus_import: '1'
status: public
title: CUGC for pontocerebellar hypoplasia type 9 and spastic paraplegia-63
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 27
year: '2019'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21095'
abstract:
- lang: eng
  text: 'Inspired by DNA mimic proteins, we have introduced aromatic foldamers bearing
    phosphonate groups as synthetic mimics of the charge surface of B-DNA and competitive
    inhibitors of some therapeutically relevant DNA-binding enzymes: the human DNA
    Topoisomerase 1 (Top1) and the human HIV-1 integrase (HIV-1 IN). We now report
    on variants of these anionic foldamers bearing carboxylates instead of phosphonates.
    Several new monomers have been synthesized with protecting groups suitable for
    solid phase synthesis (SPS). Six hexadecaamides have been prepared using SPS.
    Proof of their resemblance to B-DNA was brought by the first crystal structure
    of one of these DNA-mimic foldamers in its polyanionic form. While some of the
    foldamers were found to be as active as, or even more active than, the original
    phosphonate oligomers, others had no activity at all or could even stimulate enzyme
    activity in vitro. Some foldamers were found to have differential inhibitory effects
    on the two enzymes. These results demonstrate a strong dependence of inhibitory
    activity on foldamer structure and charge distribution. They open broad avenues
    for the development of new classes of derivatives that could inhibit the interaction
    of specific proteins with their DNA target thereby influencing the cellular pathways
    in which they are involved.'
article_processing_charge: No
article_type: original
author:
- first_name: Valentina
  full_name: Corvaglia, Valentina
  last_name: Corvaglia
- first_name: Daniel
  full_name: Carbajo, Daniel
  last_name: Carbajo
- first_name: Panchami
  full_name: Prabhakaran, Panchami
  last_name: Prabhakaran
- first_name: Krzysztof
  full_name: Ziach, Krzysztof
  last_name: Ziach
- first_name: Pradeep K
  full_name: Mandal, Pradeep K
  id: 6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
  last_name: Mandal
  orcid: 0000-0001-5996-956X
- first_name: Victor Dos
  full_name: Santos, Victor Dos
  last_name: Santos
- first_name: Carole
  full_name: Legeay, Carole
  last_name: Legeay
- first_name: Rachel
  full_name: Vogel, Rachel
  last_name: Vogel
- first_name: Vincent
  full_name: Parissi, Vincent
  last_name: Parissi
- first_name: Philippe
  full_name: Pourquier, Philippe
  last_name: Pourquier
- first_name: Ivan
  full_name: Huc, Ivan
  last_name: Huc
citation:
  ama: 'Corvaglia V, Carbajo D, Prabhakaran P, et al. Carboxylate-functionalized foldamer
    inhibitors of HIV-1 integrase and Topoisomerase 1: Artificial analogues of DNA
    mimic proteins. <i>Nucleic Acids Research</i>. 2019;47(11):5511-5521. doi:<a href="https://doi.org/10.1093/nar/gkz352">10.1093/nar/gkz352</a>'
  apa: 'Corvaglia, V., Carbajo, D., Prabhakaran, P., Ziach, K., Mandal, P. K., Santos,
    V. D., … Huc, I. (2019). Carboxylate-functionalized foldamer inhibitors of HIV-1
    integrase and Topoisomerase 1: Artificial analogues of DNA mimic proteins. <i>Nucleic
    Acids Research</i>. Oxford University Press. <a href="https://doi.org/10.1093/nar/gkz352">https://doi.org/10.1093/nar/gkz352</a>'
  chicago: 'Corvaglia, Valentina, Daniel Carbajo, Panchami Prabhakaran, Krzysztof
    Ziach, Pradeep K Mandal, Victor Dos Santos, Carole Legeay, et al. “Carboxylate-Functionalized
    Foldamer Inhibitors of HIV-1 Integrase and Topoisomerase 1: Artificial Analogues
    of DNA Mimic Proteins.” <i>Nucleic Acids Research</i>. Oxford University Press,
    2019. <a href="https://doi.org/10.1093/nar/gkz352">https://doi.org/10.1093/nar/gkz352</a>.'
  ieee: 'V. Corvaglia <i>et al.</i>, “Carboxylate-functionalized foldamer inhibitors
    of HIV-1 integrase and Topoisomerase 1: Artificial analogues of DNA mimic proteins,”
    <i>Nucleic Acids Research</i>, vol. 47, no. 11. Oxford University Press, pp. 5511–5521,
    2019.'
  ista: 'Corvaglia V, Carbajo D, Prabhakaran P, Ziach K, Mandal PK, Santos VD, Legeay
    C, Vogel R, Parissi V, Pourquier P, Huc I. 2019. Carboxylate-functionalized foldamer
    inhibitors of HIV-1 integrase and Topoisomerase 1: Artificial analogues of DNA
    mimic proteins. Nucleic Acids Research. 47(11), 5511–5521.'
  mla: 'Corvaglia, Valentina, et al. “Carboxylate-Functionalized Foldamer Inhibitors
    of HIV-1 Integrase and Topoisomerase 1: Artificial Analogues of DNA Mimic Proteins.”
    <i>Nucleic Acids Research</i>, vol. 47, no. 11, Oxford University Press, 2019,
    pp. 5511–21, doi:<a href="https://doi.org/10.1093/nar/gkz352">10.1093/nar/gkz352</a>.'
  short: V. Corvaglia, D. Carbajo, P. Prabhakaran, K. Ziach, P.K. Mandal, V.D. Santos,
    C. Legeay, R. Vogel, V. Parissi, P. Pourquier, I. Huc, Nucleic Acids Research
    47 (2019) 5511–5521.
date_created: 2026-01-29T21:17:15Z
date_published: 2019-06-20T00:00:00Z
date_updated: 2026-02-23T09:56:28Z
day: '20'
doi: 10.1093/nar/gkz352
extern: '1'
has_accepted_license: '1'
intvolume: '        47'
issue: '11'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1093/nar/gkz352
month: '06'
oa: 1
oa_version: Published Version
page: 5511-5521
publication: Nucleic Acids Research
publication_identifier:
  eissn:
  - 1362-4962
  issn:
  - 0305-1048
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
status: public
title: 'Carboxylate-functionalized foldamer inhibitors of HIV-1 integrase and Topoisomerase
  1: Artificial analogues of DNA mimic proteins'
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 47
year: '2019'
...
