---
OA_place: repository
OA_type: green
_id: '21135'
abstract:
- lang: eng
  text: Three-dimensional (3D) microscopy data is often anisotropic with significantly
    lower resolution (up to 8x) along the z axis than along the xy axes. Computationally
    generating plausible isotropic resolution from anisotropic imaging data would
    benefit the visual analysis of large-scale volumes. This paper proposes niiv,
    a self-supervised method for isotropic reconstruction of 3D microscopy data that
    can quickly produce images at arbitrary output resolutions. The representation
    embeds a learned latent code within a neural field that describes the implicit
    higher-resolution isotropic image region. We use an attention-guided latent interpolation
    approach, which allows flexible information exchange over a local latent neighborhood.
    Under isotropic volume assumptions, we self-supervise this representation on low-/high-resolution
    lateral image pairs to reconstruct an isotropic volume from low-resolution axial
    images. We evaluate our method on simulated and real anisotropic electron (EM)
    and light microscopy (LM) data. Compared to diffusion-based baselines, niiv shows
    improved reconstruction quality (+1 dB PSNR) and is over three orders of magnitude
    faster (1,000x) to infer. Specifically, niiv reconstructs a 128^3 voxel volume
    in 2/10th of a second, renderable at varying (continuous) high resolutions for
    display. Our code is available at https://github.com/jakobtroidl/niiv-miccai.
acknowledgement: This work was supported by NIH grants 1U01NS132158 and R01HD104969.
  We thank the reviewers for their constructive feedback.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Jakob
  full_name: Troidl, Jakob
  last_name: Troidl
- first_name: Yiqing
  full_name: Liang, Yiqing
  last_name: Liang
- first_name: Johanna
  full_name: Beyer, Johanna
  last_name: Beyer
- first_name: Mojtaba
  full_name: Tavakoli, Mojtaba
  id: 3A0A06F4-F248-11E8-B48F-1D18A9856A87
  last_name: Tavakoli
  orcid: 0000-0002-7667-6854
- first_name: Johann G
  full_name: Danzl, Johann G
  id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
  last_name: Danzl
  orcid: 0000-0001-8559-3973
- first_name: Markus
  full_name: Hadwiger, Markus
  last_name: Hadwiger
- first_name: Hanspeter
  full_name: Pfister, Hanspeter
  last_name: Pfister
- first_name: James
  full_name: Tompkin, James
  last_name: Tompkin
citation:
  ama: 'Troidl J, Liang Y, Beyer J, et al. niiv: Interactive Self-supervised Neural
    Implicit Isotropic Volume Reconstruction. In: <i>1st International Workshop on
    Efficient Medical Artificial Intelligence</i>. Vol 16318. Springer Nature; 2026:257-267.
    doi:<a href="https://doi.org/10.1007/978-3-032-13961-0_26">10.1007/978-3-032-13961-0_26</a>'
  apa: 'Troidl, J., Liang, Y., Beyer, J., Tavakoli, M., Danzl, J. G., Hadwiger, M.,
    … Tompkin, J. (2026). niiv: Interactive Self-supervised Neural Implicit Isotropic
    Volume Reconstruction. In <i>1st International Workshop on Efficient Medical Artificial
    Intelligence</i> (Vol. 16318, pp. 257–267). Daejeon, South Korea: Springer Nature.
    <a href="https://doi.org/10.1007/978-3-032-13961-0_26">https://doi.org/10.1007/978-3-032-13961-0_26</a>'
  chicago: 'Troidl, Jakob, Yiqing Liang, Johanna Beyer, Mojtaba Tavakoli, Johann G
    Danzl, Markus Hadwiger, Hanspeter Pfister, and James Tompkin. “Niiv: Interactive
    Self-Supervised Neural Implicit Isotropic Volume Reconstruction.” In <i>1st International
    Workshop on Efficient Medical Artificial Intelligence</i>, 16318:257–67. Springer
    Nature, 2026. <a href="https://doi.org/10.1007/978-3-032-13961-0_26">https://doi.org/10.1007/978-3-032-13961-0_26</a>.'
  ieee: 'J. Troidl <i>et al.</i>, “niiv: Interactive Self-supervised Neural Implicit
    Isotropic Volume Reconstruction,” in <i>1st International Workshop on Efficient
    Medical Artificial Intelligence</i>, Daejeon, South Korea, 2026, vol. 16318, pp.
    257–267.'
  ista: 'Troidl J, Liang Y, Beyer J, Tavakoli M, Danzl JG, Hadwiger M, Pfister H,
    Tompkin J. 2026. niiv: Interactive Self-supervised Neural Implicit Isotropic Volume
    Reconstruction. 1st International Workshop on Efficient Medical Artificial Intelligence.
    EMA4MICCAI: Efficient Medical Artificial Intelligence, LNCS, vol. 16318, 257–267.'
  mla: 'Troidl, Jakob, et al. “Niiv: Interactive Self-Supervised Neural Implicit Isotropic
    Volume Reconstruction.” <i>1st International Workshop on Efficient Medical Artificial
    Intelligence</i>, vol. 16318, Springer Nature, 2026, pp. 257–67, doi:<a href="https://doi.org/10.1007/978-3-032-13961-0_26">10.1007/978-3-032-13961-0_26</a>.'
  short: J. Troidl, Y. Liang, J. Beyer, M. Tavakoli, J.G. Danzl, M. Hadwiger, H. Pfister,
    J. Tompkin, in:, 1st International Workshop on Efficient Medical Artificial Intelligence,
    Springer Nature, 2026, pp. 257–267.
conference:
  end_date: 2025-09-23
  location: Daejeon, South Korea
  name: 'EMA4MICCAI: Efficient Medical Artificial Intelligence'
  start_date: 2025-09-23
date_created: 2026-02-01T23:01:44Z
date_published: 2026-01-03T00:00:00Z
date_updated: 2026-02-16T08:50:50Z
day: '03'
department:
- _id: JoDa
doi: 10.1007/978-3-032-13961-0_26
intvolume: '     16318'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1101/2024.09.07.611785
month: '01'
oa: 1
oa_version: Preprint
page: 257-267
publication: 1st International Workshop on Efficient Medical Artificial Intelligence
publication_identifier:
  eissn:
  - 1611-3349
  isbn:
  - '9783032139603'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - relation: software
    url: https://github.com/jakobtroidl/niiv-miccai
scopus_import: '1'
status: public
title: 'niiv: Interactive Self-supervised Neural Implicit Isotropic Volume Reconstruction'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16318
year: '2026'
...
---
OA_place: repository
_id: '21137'
acknowledged_ssus:
- _id: Bio
- _id: EM-Fac
- _id: ScienComp
- _id: LifeSc
acknowledgement: We thank all members of the Heisenberg, Henkes, and Hannezo groups
  for their support. We are also grateful to the Imaging and Optics, Scientific Computing,
  Life Science Support, and Cryo-Electron Microscopy facilities at ISTA for their
  technical assistance and support. Numerical simulations were performed using the
  computational resources from Lorentz Institute and the Academic Leiden Interdisciplinary
  Cluster Environment (ALICE) provided by Leiden University, and from PMMH provided
  by Sorbonne Université. S.N has received funding from European Union’s Horizon 2020
  research and innovation programme (grant agreement No. 665385). This work was supported
  by the Austrian Science Fund (FWF) under projects PAT5044023 and W1250 awarded to
  C.-P.H.
article_processing_charge: No
author:
- first_name: Suyash
  full_name: Naik, Suyash
  id: 2C0B105C-F248-11E8-B48F-1D18A9856A87
  last_name: Naik
  orcid: 0000-0001-8421-5508
citation:
  ama: Naik S. Data associated with Keratins coordinate tissue spreading . 2026. doi:<a
    href="https://doi.org/10.15479/AT-ISTA-21137">10.15479/AT-ISTA-21137</a>
  apa: Naik, S. (2026). Data associated with Keratins coordinate tissue spreading
    . Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-21137">https://doi.org/10.15479/AT-ISTA-21137</a>
  chicago: Naik, Suyash. “Data Associated with Keratins Coordinate Tissue Spreading
    .” Institute of Science and Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-21137">https://doi.org/10.15479/AT-ISTA-21137</a>.
  ieee: S. Naik, “Data associated with Keratins coordinate tissue spreading .” Institute
    of Science and Technology Austria, 2026.
  ista: Naik S. 2026. Data associated with Keratins coordinate tissue spreading ,
    Institute of Science and Technology Austria, <a href="https://doi.org/10.15479/AT-ISTA-21137">10.15479/AT-ISTA-21137</a>.
  mla: Naik, Suyash. <i>Data Associated with Keratins Coordinate Tissue Spreading
    </i>. Institute of Science and Technology Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-21137">10.15479/AT-ISTA-21137</a>.
  short: S. Naik, (2026).
contributor:
- contributor_type: researcher
  first_name: Yann-Edwin
  last_name: Keta
- contributor_type: supervisor
  first_name: 'Silke '
  last_name: Henkes
- contributor_type: supervisor
  first_name: Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- contributor_type: supervisor
  first_name: Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
corr_author: '1'
date_created: 2026-02-04T16:38:02Z
date_published: 2026-03-24T00:00:00Z
date_updated: 2026-06-10T09:44:10Z
day: '24'
department:
- _id: GradSch
- _id: CaHe
- _id: EdHa
doi: 10.15479/AT-ISTA-21137
ec_funded: 1
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  creator: snaik
  date_created: 2026-03-16T11:51:10Z
  date_updated: 2026-03-16T11:51:10Z
  description: 'Python3 library written in C++20 to integrate vertex models. Please
    read the readme at https://github.com/yketa/cells/blob/main/README.md for detailed
    instructions for installation and usage of the code in this repository. '
  file_id: '21461'
  file_name: cells-main.zip
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  file_name: ReadMe.md
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file_date_updated: 2026-03-24T07:21:43Z
has_accepted_license: '1'
license: https://creativecommons.org/licenses/by-sa/4.0/
month: '3'
oa: 1
oa_version: Published Version
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
- _id: 8f060199-16d5-11f0-9cad-f3253b266c46
  grant_number: PAT 5044023
  name: Keratins in epithelial tissue spreading
- _id: 252C3B08-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: W1250-B20
  name: Nano-Analytics of Cellular Systems
publisher: Institute of Science and Technology Austria
status: public
title: 'Data associated with Keratins coordinate tissue spreading '
tmp:
  image: /images/cc_by_sa.png
  legal_code_url: https://creativecommons.org/licenses/by-sa/4.0/legalcode
  name: Creative Commons Attribution-ShareAlike 4.0 International Public License (CC
    BY-SA 4.0)
  short: CC BY-SA (4.0)
type: research_data
user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21140'
abstract:
- lang: eng
  text: 'We consider several problems related to packing forests in graphs. The first
    one is to find k edge-disjoint forests in a directed graph G of maximal size such
    that the indegree of each vertex in these forests is at most k. We describe a
    min-max characterization for this problem and show that it can be solved in almost
    linear time for fixed k, extending the algorithm of [Gabow, 1995]. Specifically,
    the complexity is O(kδm log n), where n, m are the number of vertices and edges
    in G respectively, and δ = max{1, k − kG}, where kG is the edge connectivity of
    the graph. Using our solution to this problem, we improve complexities for two
    existing applications:(1) k-forest problem: find k forests in an undirected graph
    G maximizing the number of edges in their union. We show how to solve this problem
    in O(k3 min{kn, m} log2 n + k · MAXFLOW(m, m) log n) time, breaking the Ok(n3/2)
    complexity barrier of previously known approaches.(2) Directed edge-connectivity
    augmentation problem: find a smallest set of directed edges whose addition to
    the given directed graph makes it strongly k-connected. We improve the deterministic
    complexity for this problem from O(kδ(m + δn) log n) [Gabow, STOC 1994] to O(kδm
    log n). A similar approach with the same complexity also works for the undirected
    version of the problem.'
article_processing_charge: No
arxiv: 1
author:
- first_name: Pavel
  full_name: Arkhipov, Pavel
  id: b25f2ab2-1fed-11ee-8599-fe02d211784f
  last_name: Arkhipov
- first_name: Vladimir
  full_name: Kolmogorov, Vladimir
  id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87
  last_name: Kolmogorov
citation:
  ama: 'Arkhipov P, Kolmogorov V. Faster algorithms for packing forests in graphs
    and related problems. In: <i>Proceedings of the 2026 Annual ACM-SIAM Symposium
    on Discrete Algorithms</i>. Society for Industrial and Applied Mathematics; 2026:4023-4042.
    doi:<a href="https://doi.org/10.1137/1.9781611978971.148">10.1137/1.9781611978971.148</a>'
  apa: 'Arkhipov, P., &#38; Kolmogorov, V. (2026). Faster algorithms for packing forests
    in graphs and related problems. In <i>Proceedings of the 2026 Annual ACM-SIAM
    Symposium on Discrete Algorithms</i> (pp. 4023–4042). Vancouver, Canada: Society
    for Industrial and Applied Mathematics. <a href="https://doi.org/10.1137/1.9781611978971.148">https://doi.org/10.1137/1.9781611978971.148</a>'
  chicago: Arkhipov, Pavel, and Vladimir Kolmogorov. “Faster Algorithms for Packing
    Forests in Graphs and Related Problems.” In <i>Proceedings of the 2026 Annual
    ACM-SIAM Symposium on Discrete Algorithms</i>, 4023–42. Society for Industrial
    and Applied Mathematics, 2026. <a href="https://doi.org/10.1137/1.9781611978971.148">https://doi.org/10.1137/1.9781611978971.148</a>.
  ieee: P. Arkhipov and V. Kolmogorov, “Faster algorithms for packing forests in graphs
    and related problems,” in <i>Proceedings of the 2026 Annual ACM-SIAM Symposium
    on Discrete Algorithms</i>, Vancouver, Canada, 2026, pp. 4023–4042.
  ista: 'Arkhipov P, Kolmogorov V. 2026. Faster algorithms for packing forests in
    graphs and related problems. Proceedings of the 2026 Annual ACM-SIAM Symposium
    on Discrete Algorithms. SODA: Symposium on Discrete Algorithms, 4023–4042.'
  mla: Arkhipov, Pavel, and Vladimir Kolmogorov. “Faster Algorithms for Packing Forests
    in Graphs and Related Problems.” <i>Proceedings of the 2026 Annual ACM-SIAM Symposium
    on Discrete Algorithms</i>, Society for Industrial and Applied Mathematics, 2026,
    pp. 4023–42, doi:<a href="https://doi.org/10.1137/1.9781611978971.148">10.1137/1.9781611978971.148</a>.
  short: P. Arkhipov, V. Kolmogorov, in:, Proceedings of the 2026 Annual ACM-SIAM
    Symposium on Discrete Algorithms, Society for Industrial and Applied Mathematics,
    2026, pp. 4023–4042.
conference:
  end_date: 2026-01-14
  location: Vancouver, Canada
  name: 'SODA: Symposium on Discrete Algorithms'
  start_date: 2026-01-11
corr_author: '1'
date_created: 2026-02-05T10:51:34Z
date_published: 2026-01-07T00:00:00Z
date_updated: 2026-02-16T09:18:33Z
day: '07'
department:
- _id: VlKo
doi: 10.1137/1.9781611978971.148
external_id:
  arxiv:
  - '2409.20314'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2409.20314
month: '01'
oa: 1
oa_version: Preprint
page: 4023-4042
publication: Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms
publication_identifier:
  eisbn:
  - '9781611978971'
publication_status: published
publisher: Society for Industrial and Applied Mathematics
quality_controlled: '1'
status: public
title: Faster algorithms for packing forests in graphs and related problems
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21149'
abstract:
- lang: eng
  text: We present a general theoretical framework for helical dichroism (HD), establishing
    an explicit link between chiral resolution and orbital angular momentum (OAM)
    exchange in light–matter interaction. Tracing microscopic mechanisms of the OAM
    transfer, we derive rotational selection rules, which establish that HD emerges
    only from the spin–orbit coupling of light, even for beams without the far-field
    OAM. Our findings refine the conditions for observing HD, provide a tool to re-examine
    the outcome of prior experiments, and guide future designs for chiral sensing
    with structured light.
acknowledgement: This research was funded in whole or in part by the Austrian Science
  Fund (FWF) [10.55776/F1004].
article_number: '053204'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Mateja
  full_name: Hrast, Mateja
  id: 48dbb294-2a9c-11ef-905d-f56be71f0e5d
  last_name: Hrast
- first_name: Georgios
  full_name: Koutentakis, Georgios
  id: d7b23d3a-9e21-11ec-b482-f76739596b95
  last_name: Koutentakis
- first_name: Mikhail
  full_name: Maslov, Mikhail
  id: 2E65BB0E-F248-11E8-B48F-1D18A9856A87
  last_name: Maslov
  orcid: 0000-0003-4074-2570
- first_name: Mikhail
  full_name: Lemeshko, Mikhail
  id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
  last_name: Lemeshko
  orcid: 0000-0002-6990-7802
citation:
  ama: Hrast M, Koutentakis G, Maslov M, Lemeshko M. Bottom-up analysis of rovibrational
    helical dichroism. <i>Physical Review Letters</i>. 2026;136(5). doi:<a href="https://doi.org/10.1103/fkf1-1jml">10.1103/fkf1-1jml</a>
  apa: Hrast, M., Koutentakis, G., Maslov, M., &#38; Lemeshko, M. (2026). Bottom-up
    analysis of rovibrational helical dichroism. <i>Physical Review Letters</i>. American
    Physical Society. <a href="https://doi.org/10.1103/fkf1-1jml">https://doi.org/10.1103/fkf1-1jml</a>
  chicago: Hrast, Mateja, Georgios Koutentakis, Mikhail Maslov, and Mikhail Lemeshko.
    “Bottom-up Analysis of Rovibrational Helical Dichroism.” <i>Physical Review Letters</i>.
    American Physical Society, 2026. <a href="https://doi.org/10.1103/fkf1-1jml">https://doi.org/10.1103/fkf1-1jml</a>.
  ieee: M. Hrast, G. Koutentakis, M. Maslov, and M. Lemeshko, “Bottom-up analysis
    of rovibrational helical dichroism,” <i>Physical Review Letters</i>, vol. 136,
    no. 5. American Physical Society, 2026.
  ista: Hrast M, Koutentakis G, Maslov M, Lemeshko M. 2026. Bottom-up analysis of
    rovibrational helical dichroism. Physical Review Letters. 136(5), 053204.
  mla: Hrast, Mateja, et al. “Bottom-up Analysis of Rovibrational Helical Dichroism.”
    <i>Physical Review Letters</i>, vol. 136, no. 5, 053204, American Physical Society,
    2026, doi:<a href="https://doi.org/10.1103/fkf1-1jml">10.1103/fkf1-1jml</a>.
  short: M. Hrast, G. Koutentakis, M. Maslov, M. Lemeshko, Physical Review Letters
    136 (2026).
corr_author: '1'
date_created: 2026-02-06T10:53:17Z
date_published: 2026-02-05T00:00:00Z
date_updated: 2026-02-10T11:30:37Z
day: '05'
ddc:
- '530'
department:
- _id: MiLe
doi: 10.1103/fkf1-1jml
external_id:
  arxiv:
  - '2505.16393'
file:
- access_level: open_access
  checksum: 805c929fff9fd4d0e733293eaace67b8
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-10T11:25:46Z
  date_updated: 2026-02-10T11:25:46Z
  file_id: '21210'
  file_name: 2026_PhysicalReviewLetters_Hrast.pdf
  file_size: 511312
  relation: main_file
  success: 1
file_date_updated: 2026-02-10T11:25:46Z
has_accepted_license: '1'
intvolume: '       136'
issue: '5'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: 7c040762-9f16-11ee-852c-dd79eeee4ab3
  grant_number: F100403
  name: Coherent Optical Metrology Beyond Electric-Dipole-Allowed Transitions
publication: Physical Review Letters
publication_identifier:
  eissn:
  - 1079-7114
  issn:
  - 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Bottom-up analysis of rovibrational helical dichroism
tmp:
  image: /images/cc_by.png
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  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 136
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21158'
abstract:
- lang: eng
  text: Vernalization-regulated flowering is vital for wheat yield and geographical
    distribution, and the diversity of flowering time genes is essential for the breeding
    of climate-resilient varieties. Sugars have long been recognized in regulating
    flowering; however, the intrinsic connection between carbohydrate metabolism and
    vernalization response remains largely unexplored. Here, we identify a fructose
    1,6-bisphosphate aldolase (FBA) encoding gene, HtL1/FBA10, as a modulator of heading
    time variation based on a genome-wide association study utilizing wheat core germplasm
    collections. Evolutionary analysis shows a decrease in the proportion of haplotype-2
    of HtL1, which is linked to delayed flowering, in Chinese and American wheat varieties
    compared to landraces. Vernalization reduces HtL1/FBA10 phosphorylation levels
    and  increases  its O-GlcNAcylation, which in turn enhances its enzymatic activity
    and facilitates VERNALIZATION 1 (VRN1) transcription by regulating histone acetylation
    at the VRN1 locus. Our findings provide mechanistic insights into the interplay
    between glucose metabolism and the epigenetic regulation of vernalization in winter
    wheat.
acknowledgement: This work was supported by the Basic Science Center Project of National
  Natural Science Foundation of China (32388201) to K.C and the National Natural Science
  Foundation of China (31970331) to L.X. We thank Dr. Zhuang Lu, Dr. Bin Han and Ms.
  Jingquan Li (Plant Science Facility of the Institute of Botany, Chinese Academy
  of Sciences) for their technical assistance in LC-MS/MS assay, small molecule compound
  analysis and the subcellular localization assay, respectively. We thank Dr. Wei
  Luo and Dr. Dongfeng Liu for helpful discussions.
article_number: '999'
article_processing_charge: Yes
article_type: original
author:
- first_name: Pengfang
  full_name: Yang, Pengfang
  last_name: Yang
- first_name: Yangyang
  full_name: Liu, Yangyang
  last_name: Liu
- first_name: Qi
  full_name: Dong, Qi
  last_name: Dong
- first_name: Yuting
  full_name: Miao, Yuting
  last_name: Miao
- first_name: Jianlong
  full_name: Zhang, Jianlong
  last_name: Zhang
- first_name: Shujuan
  full_name: Xu, Shujuan
  id: 9724dd9d-f591-11ee-bd51-e97ed0652286
  last_name: Xu
- first_name: Hong
  full_name: Zhao, Hong
  last_name: Zhao
- first_name: Yuda
  full_name: Niu, Yuda
  last_name: Niu
- first_name: Xueyong
  full_name: Zhang, Xueyong
  last_name: Zhang
- first_name: Yunyuan
  full_name: Xu, Yunyuan
  last_name: Xu
- first_name: Zifeng
  full_name: Guo, Zifeng
  last_name: Guo
- first_name: Lijing
  full_name: Xing, Lijing
  last_name: Xing
- first_name: Kang
  full_name: Chong, Kang
  last_name: Chong
citation:
  ama: Yang P, Liu Y, Dong Q, et al. O-GlcNAc and phosphorylation modifications on
    HtL1/FBA10 regulate wheat vernalization for flowering. <i>Nature Communications</i>.
    2026;17. doi:<a href="https://doi.org/10.1038/s41467-025-67734-0">10.1038/s41467-025-67734-0</a>
  apa: Yang, P., Liu, Y., Dong, Q., Miao, Y., Zhang, J., Xu, S., … Chong, K. (2026).
    O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization
    for flowering. <i>Nature Communications</i>. Springer Nature. <a href="https://doi.org/10.1038/s41467-025-67734-0">https://doi.org/10.1038/s41467-025-67734-0</a>
  chicago: Yang, Pengfang, Yangyang Liu, Qi Dong, Yuting Miao, Jianlong Zhang, Shujuan
    Xu, Hong Zhao, et al. “O-GlcNAc and Phosphorylation Modifications on HtL1/FBA10
    Regulate Wheat Vernalization for Flowering.” <i>Nature Communications</i>. Springer
    Nature, 2026. <a href="https://doi.org/10.1038/s41467-025-67734-0">https://doi.org/10.1038/s41467-025-67734-0</a>.
  ieee: P. Yang <i>et al.</i>, “O-GlcNAc and phosphorylation modifications on HtL1/FBA10
    regulate wheat vernalization for flowering,” <i>Nature Communications</i>, vol.
    17. Springer Nature, 2026.
  ista: Yang P, Liu Y, Dong Q, Miao Y, Zhang J, Xu S, Zhao H, Niu Y, Zhang X, Xu Y,
    Guo Z, Xing L, Chong K. 2026. O-GlcNAc and phosphorylation modifications on HtL1/FBA10
    regulate wheat vernalization for flowering. Nature Communications. 17, 999.
  mla: Yang, Pengfang, et al. “O-GlcNAc and Phosphorylation Modifications on HtL1/FBA10
    Regulate Wheat Vernalization for Flowering.” <i>Nature Communications</i>, vol.
    17, 999, Springer Nature, 2026, doi:<a href="https://doi.org/10.1038/s41467-025-67734-0">10.1038/s41467-025-67734-0</a>.
  short: P. Yang, Y. Liu, Q. Dong, Y. Miao, J. Zhang, S. Xu, H. Zhao, Y. Niu, X. Zhang,
    Y. Xu, Z. Guo, L. Xing, K. Chong, Nature Communications 17 (2026).
date_created: 2026-02-08T23:02:48Z
date_published: 2026-01-27T00:00:00Z
date_updated: 2026-02-12T14:34:24Z
day: '27'
ddc:
- '580'
department:
- _id: XiFe
doi: 10.1038/s41467-025-67734-0
external_id:
  pmid:
  - '41455723'
file:
- access_level: open_access
  checksum: 9ae170ec70ba1ab56b6f1ffe67d1de7f
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-12T14:33:14Z
  date_updated: 2026-02-12T14:33:14Z
  file_id: '21223'
  file_name: 2026_NatureComm_Yang.pdf
  file_size: 4685882
  relation: main_file
  success: 1
file_date_updated: 2026-02-12T14:33:14Z
has_accepted_license: '1'
intvolume: '        17'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization
  for flowering
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21159'
abstract:
- lang: eng
  text: "One of the foundational theorems of extremal graph theory is Dirac’s theorem,
    which\r\nsays that if an n-vertex graph G has minimum degree at least n/2, then
    G has a\r\nHamilton cycle, and therefore a perfect matching (if n is even). Later
    work by Sárközy,\r\nSelkow and Szemerédi showed that in fact Dirac graphs have
    many Hamilton cycles\r\nand perfect matchings, culminating in a result of Cuckler
    and Kahn that gives a precise\r\ndescription of the numbers of Hamilton cycles
    and perfect matchings in a Dirac graph\r\nG (in terms of an entropy-like parameter
    of G). In this paper we extend Cuckler\r\nand Kahn’s result to perfect matchings
    in hypergraphs. For positive integers d < k,\r\nand for n divisible by k, let
    md (k, n) be the minimum d-degree that ensures the\r\nexistence of a perfect matching
    in an n-vertex k-uniform hypergraph. In general, it is\r\nan open question to
    determine (even asymptotically) the values of md (k, n), but we are\r\nnonetheless
    able to prove an analogue of the Cuckler–Kahn theorem, showing that if\r\nan n-vertex
    k-uniform hypergraph G has minimum d-degree at least (1+γ )md (k, n)\r\n(for any
    constantγ > 0), then the number of perfect matchings in G is controlled by\r\nan
    entropy-like parameter of G. This strengthens cruder estimates arising from work\r\nof
    Kang–Kelly–Kühn–Osthus–Pfenninger and Pham–Sah–Sawhney–Simkin."
acknowledgement: We would like to thank the referees for a number of helpful comments
  and suggestions, which have substantially improved the paper. Open access funding
  provided by Institute of Science and Technology (IST Austria).
article_number: '5'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Matthew Alan
  full_name: Kwan, Matthew Alan
  id: 5fca0887-a1db-11eb-95d1-ca9d5e0453b3
  last_name: Kwan
  orcid: 0000-0002-4003-7567
- first_name: Roodabeh
  full_name: Safavi Hemami, Roodabeh
  id: 72ed2640-8972-11ed-ae7b-f9c81ec75154
  last_name: Safavi Hemami
- first_name: Yiting
  full_name: Wang, Yiting
  id: 1917d194-076e-11ed-97cd-837255f88785
  last_name: Wang
  orcid: 0000-0002-2856-767X
citation:
  ama: Kwan MA, Safavi Hemami R, Wang Y. Counting perfect matchings in Dirac hypergraphs.
    <i>Combinatorica</i>. 2026;46. doi:<a href="https://doi.org/10.1007/s00493-025-00194-8">10.1007/s00493-025-00194-8</a>
  apa: Kwan, M. A., Safavi Hemami, R., &#38; Wang, Y. (2026). Counting perfect matchings
    in Dirac hypergraphs. <i>Combinatorica</i>. Springer Nature. <a href="https://doi.org/10.1007/s00493-025-00194-8">https://doi.org/10.1007/s00493-025-00194-8</a>
  chicago: Kwan, Matthew Alan, Roodabeh Safavi Hemami, and Yiting Wang. “Counting
    Perfect Matchings in Dirac Hypergraphs.” <i>Combinatorica</i>. Springer Nature,
    2026. <a href="https://doi.org/10.1007/s00493-025-00194-8">https://doi.org/10.1007/s00493-025-00194-8</a>.
  ieee: M. A. Kwan, R. Safavi Hemami, and Y. Wang, “Counting perfect matchings in
    Dirac hypergraphs,” <i>Combinatorica</i>, vol. 46. Springer Nature, 2026.
  ista: Kwan MA, Safavi Hemami R, Wang Y. 2026. Counting perfect matchings in Dirac
    hypergraphs. Combinatorica. 46, 5.
  mla: Kwan, Matthew Alan, et al. “Counting Perfect Matchings in Dirac Hypergraphs.”
    <i>Combinatorica</i>, vol. 46, 5, Springer Nature, 2026, doi:<a href="https://doi.org/10.1007/s00493-025-00194-8">10.1007/s00493-025-00194-8</a>.
  short: M.A. Kwan, R. Safavi Hemami, Y. Wang, Combinatorica 46 (2026).
corr_author: '1'
date_created: 2026-02-08T23:02:49Z
date_published: 2026-02-01T00:00:00Z
date_updated: 2026-02-16T09:55:17Z
day: '01'
ddc:
- '510'
department:
- _id: MaKw
- _id: MoHe
doi: 10.1007/s00493-025-00194-8
external_id:
  arxiv:
  - '2408.09589'
file:
- access_level: open_access
  checksum: 47b0031d90b0e6b9a843f422a1486089
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-16T09:52:38Z
  date_updated: 2026-02-16T09:52:38Z
  file_id: '21228'
  file_name: 2026_Combinatorica_Kwan.pdf
  file_size: 539646
  relation: main_file
  success: 1
file_date_updated: 2026-02-16T09:52:38Z
has_accepted_license: '1'
intvolume: '        46'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
publication: Combinatorica
publication_identifier:
  eissn:
  - 1439-6912
  issn:
  - 0209-9683
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Counting perfect matchings in Dirac hypergraphs
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 46
year: '2026'
...
---
OA_place: repository
OA_type: free access
_id: '21174'
abstract:
- lang: eng
  text: UTe2 exhibits the remarkable phenomenon of re-entrant superconductivity, whereby
    the zero-resistance state reappears above 40 tesla after being suppressed with
    a field of around 10 tesla. One potential pairing mechanism, invoked in the related
    re-entrant superconductors UCoGe and URhGe, involves transverse fluctuations of
    a ferromagnetic order parameter. However, the requisite ferromagnetic order -
    present in both UCoGe and URhGe - is absent in UTe2, and magnetization measurements
    show no sign of strong fluctuations. Here, we measure the magnetotropic susceptibility
    of UTe2 across two field-angle planes. This quantity is sensitive to the magnetic
    susceptibility in a direction transverse to the applied magnetic field - a quantity
    that is not accessed in conventional magnetization measurements. We observe a
    very large decrease in the magnetotropic susceptibility over a broad range of
    field orientations, indicating a large increase in the transverse magnetic susceptibility.
    The three superconducting phases of UTe2, including the high-field re-entrant
    phase, surround this region of enhanced susceptibility in the field-angle phase
    diagram. The strongest transverse susceptibility is found near the critical end
    point of the high-field metamagnetic transition, suggesting that quantum critical
    fluctuations of a field-induced magnetic order parameter may be responsible for
    the large transverse susceptibility, and may provide a pairing mechanism for field-induced
    superconductivity in UTe2.
acknowledged_ssus:
- _id: NanoFab
acknowledgement: Thanks to Salvatore Bagiante, Evgeniia Volobueva, Lubuna Shafeek,
  Ali Bangura and Zoltan Kollo.
article_processing_charge: Yes
author:
- first_name: Kimberly A
  full_name: Modic, Kimberly A
  id: 13C26AC0-EB69-11E9-87C6-5F3BE6697425
  last_name: Modic
  orcid: 0000-0001-9760-3147
citation:
  ama: Modic KA. Research data for “Giant transverse magnetic fluctuations at the
    edge of re-entrant superconductivity in UTe2.” 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-21174">10.15479/AT-ISTA-21174</a>
  apa: Modic, K. A. (2026). Research data for “Giant transverse magnetic fluctuations
    at the edge of re-entrant superconductivity in UTe2.” Institute of Science and
    Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-21174">https://doi.org/10.15479/AT-ISTA-21174</a>
  chicago: Modic, Kimberly A. “Research Data for ‘Giant Transverse Magnetic Fluctuations
    at the Edge of Re-Entrant Superconductivity in UTe2.’” Institute of Science and
    Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-21174">https://doi.org/10.15479/AT-ISTA-21174</a>.
  ieee: K. A. Modic, “Research data for ‘Giant transverse magnetic fluctuations at
    the edge of re-entrant superconductivity in UTe2.’” Institute of Science and Technology
    Austria, 2026.
  ista: Modic KA. 2026. Research data for ‘Giant transverse magnetic fluctuations
    at the edge of re-entrant superconductivity in UTe2’, Institute of Science and
    Technology Austria, <a href="https://doi.org/10.15479/AT-ISTA-21174">10.15479/AT-ISTA-21174</a>.
  mla: Modic, Kimberly A. <i>Research Data for “Giant Transverse Magnetic Fluctuations
    at the Edge of Re-Entrant Superconductivity in UTe2.”</i> Institute of Science
    and Technology Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-21174">10.15479/AT-ISTA-21174</a>.
  short: K.A. Modic, (2026).
contributor:
- contributor_type: project_member
  first_name: Valeska
  id: 467ed36b-dc96-11ea-b7c8-b043a380b282
  last_name: Zambra
  orcid: 0000-0002-8806-5719
corr_author: '1'
date_created: 2026-02-09T12:04:20Z
date_published: 2026-02-19T00:00:00Z
date_updated: 2026-05-11T06:35:59Z
day: '19'
ddc:
- '530'
department:
- _id: KiMo
doi: 10.15479/AT-ISTA-21174
file:
- access_level: open_access
  checksum: 53157d908fba663275c2b8dc6ee84fdb
  content_type: text/plain
  creator: kmodic
  date_created: 2026-02-19T07:38:15Z
  date_updated: 2026-02-19T07:38:15Z
  file_id: '21332'
  file_name: README.txt
  file_size: 1347
  relation: main_file
  success: 1
- access_level: open_access
  checksum: b2c8ca5620ee9c181a42082068d3d73c
  content_type: application/zip
  creator: kmodic
  date_created: 2026-02-19T07:39:03Z
  date_updated: 2026-02-19T07:39:03Z
  file_id: '21333'
  file_name: processed_data_bc_plane_Fig2d.zip
  file_size: 534853
  relation: main_file
  success: 1
- access_level: open_access
  checksum: 976bf113da4b1133313f0b292e71289f
  content_type: application/zip
  creator: kmodic
  date_created: 2026-02-19T07:39:07Z
  date_updated: 2026-02-19T07:39:07Z
  file_id: '21334'
  file_name: processed_data_ac_plane_Fig2c.zip
  file_size: 427144
  relation: main_file
  success: 1
file_date_updated: 2026-02-19T07:39:07Z
has_accepted_license: '1'
keyword:
- transverse magnetic susceptibility
- magnetotropic
- superconductivity
- magnetic fluctuations
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: bd968c70-d553-11ed-ba76-cde40b0aba64
  grant_number: '101078696'
  name: Gaining leverage with spin liquids and superconductors
publisher: Institute of Science and Technology Austria
related_material:
  link:
  - relation: preprint
    url: https://arxiv.org/pdf/2506.08984
  record:
  - id: '21845'
    relation: used_in_publication
    status: public
status: public
title: Research data for "Giant transverse magnetic fluctuations at the edge of re-entrant
  superconductivity in UTe2"
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: research_data
user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21212'
abstract:
- lang: eng
  text: "Malignant glioma is incurable. Using a mouse genetic mosaic system to generate
    sporadic Trp53,Nf1-null OPCs, we previously identified oligodendrocyte precursor
    cell (OPC) as a cell-of-origin of glioma. Here, we report that pre-malignant Trp53,Nf1-null
    OPCs outcompete wildtype counterparts during their expansion. Blocking competition
    by mutating/strengthening wildtype OPCs impeded both pre-malignant progression
    and malignant expansion of glioma.\r\n\r\n“In-tissue” phosphoproteomic profiling
    revealed an enrichment of phosphopeptides related to RNA splicing and protein
    translation at the peak of cell competition, suggesting that competitiveness may
    stem from unique protein species. Among candidates was mTORC1, whose pharmacological
    inhibition or genetic disruption resulted in a loss of competitiveness in our
    mouse model. Finally, analysis of patient biopsies and interrogating the role
    of individual gliomagenic mutations in OPC competition supported its relevance
    in human gliomas. Together, these findings identified the driving role of competitive
    interactions among OPCs in gliomagenesis, and suggest unconventional therapeutic
    strategies to target this process."
acknowledgement: "We thank Dr. Wenjie Liu for providing critical feedback on the manuscript.
  We also thank Dr.\r\nPat Pramoonjago at the Biorepository and Tissue Research Facility,
  and Hope Davis at the\r\nvivarium for their assistance on the project. These Core
  Facilities are supported by UVA Cancer\r\nCenter grant #P30-CA044579. We are grateful
  to Dr. Jonathan A. Epstein for providing the\r\nNf1GRD/+ mouse strain (https://pubmed.ncbi.nlm.nih.gov/26460546/).
  This work was partly\r\nsupported by the National Institute of Neurological Diseases
  and Stroke R21 NS125479-01A1\r\n(H.Z.), American Cancer Society Institutional Research
  Grant to the University of Virginia\r\n(Y.J.), the National Natural Science Foundation
  of China #82072787 (M.Y.), the National\r\nCancer Institute U54 CA238114 (F.W.),
  U01 CA284193 (K.M.N.), and U54 CA274499 (K.A.J.,\r\nM.F-S.), the National institute
  of General Medical Sciences R35 GM133404 (M.F-S.), the Dr.\r\nMiriam and Sheldon
  G. Adelson Medical Research Foundation (H.I.K., S.A.G.), the National\r\nCenter
  for Advancing Translational Sciences KL2TR001882 (K.S.P.), Tower Cancer Career Development
  Grant (K.S.P.), McKnight Neurobiology of Brain Disorders Grant (K.S.P.). The\r\ncontent
  is solely the responsibility of the authors and does not necessarily represent the
  official\r\nviews of the National Institutes of Health. Illustrations in this manuscript
  were created with\r\nBioRender (BioRender.com)."
article_processing_charge: No
author:
- first_name: Ying
  full_name: Jiang, Ying
  last_name: Jiang
- first_name: Ryuhjin
  full_name: Ahn, Ryuhjin
  last_name: Ahn
- first_name: Arthur
  full_name: Huang, Arthur
  last_name: Huang
- first_name: Phillippe P.
  full_name: Gonzalez, Phillippe P.
  last_name: Gonzalez
- first_name: Jungeun
  full_name: Kim, Jungeun
  last_name: Kim
- first_name: Guoxin
  full_name: Zhang, Guoxin
  last_name: Zhang
- first_name: Zihao
  full_name: Liu, Zihao
  last_name: Liu
- first_name: Zhenqiang
  full_name: He, Zhenqiang
  last_name: He
- first_name: Lindsey
  full_name: Dudley, Lindsey
  last_name: Dudley
- first_name: Kunal S.
  full_name: Patel, Kunal S.
  last_name: Patel
- first_name: Godfrey A.
  full_name: Dzhivhuho, Godfrey A.
  last_name: Dzhivhuho
- first_name: Sam
  full_name: Crowl, Sam
  last_name: Crowl
- first_name: Piotr
  full_name: Przanowski, Piotr
  last_name: Przanowski
- first_name: Luisa Quesada
  full_name: Camacho, Luisa Quesada
  last_name: Camacho
- first_name: Sijie
  full_name: Hao, Sijie
  last_name: Hao
- first_name: Jianhao
  full_name: Zeng, Jianhao
  last_name: Zeng
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: Mohammad
  full_name: Fallahi-Sichani, Mohammad
  last_name: Fallahi-Sichani
- first_name: Kevin A.
  full_name: Janes, Kevin A.
  last_name: Janes
- first_name: Kristen M.
  full_name: Naegle, Kristen M.
  last_name: Naegle
- first_name: Marie-Louise
  full_name: Hammarskjold, Marie-Louise
  last_name: Hammarskjold
- first_name: Steven A.
  full_name: Goldman, Steven A.
  last_name: Goldman
- first_name: Harley I.
  full_name: Kornblum, Harley I.
  last_name: Kornblum
- first_name: Maojin
  full_name: Yao, Maojin
  last_name: Yao
- first_name: Forest
  full_name: White, Forest
  last_name: White
- first_name: Hui
  full_name: Zong, Hui
  last_name: Zong
citation:
  ama: Jiang Y, Ahn R, Huang A, et al. Critical role of cell competition in gliomagenesis.
    <i>bioRxiv</i>. 2026. doi:<a href="https://doi.org/10.64898/2026.01.15.699808">10.64898/2026.01.15.699808</a>
  apa: Jiang, Y., Ahn, R., Huang, A., Gonzalez, P. P., Kim, J., Zhang, G., … Zong,
    H. (2026). Critical role of cell competition in gliomagenesis. <i>bioRxiv</i>.
    <a href="https://doi.org/10.64898/2026.01.15.699808">https://doi.org/10.64898/2026.01.15.699808</a>
  chicago: Jiang, Ying, Ryuhjin Ahn, Arthur Huang, Phillippe P. Gonzalez, Jungeun
    Kim, Guoxin Zhang, Zihao Liu, et al. “Critical Role of Cell Competition in Gliomagenesis.”
    <i>BioRxiv</i>, 2026. <a href="https://doi.org/10.64898/2026.01.15.699808">https://doi.org/10.64898/2026.01.15.699808</a>.
  ieee: Y. Jiang <i>et al.</i>, “Critical role of cell competition in gliomagenesis,”
    <i>bioRxiv</i>. 2026.
  ista: Jiang Y, Ahn R, Huang A, Gonzalez PP, Kim J, Zhang G, Liu Z, He Z, Dudley
    L, Patel KS, Dzhivhuho GA, Crowl S, Przanowski P, Camacho LQ, Hao S, Zeng J, Hippenmeyer
    S, Fallahi-Sichani M, Janes KA, Naegle KM, Hammarskjold M-L, Goldman SA, Kornblum
    HI, Yao M, White F, Zong H. 2026. Critical role of cell competition in gliomagenesis.
    bioRxiv, <a href="https://doi.org/10.64898/2026.01.15.699808">10.64898/2026.01.15.699808</a>.
  mla: Jiang, Ying, et al. “Critical Role of Cell Competition in Gliomagenesis.” <i>BioRxiv</i>,
    2026, doi:<a href="https://doi.org/10.64898/2026.01.15.699808">10.64898/2026.01.15.699808</a>.
  short: Y. Jiang, R. Ahn, A. Huang, P.P. Gonzalez, J. Kim, G. Zhang, Z. Liu, Z. He,
    L. Dudley, K.S. Patel, G.A. Dzhivhuho, S. Crowl, P. Przanowski, L.Q. Camacho,
    S. Hao, J. Zeng, S. Hippenmeyer, M. Fallahi-Sichani, K.A. Janes, K.M. Naegle,
    M.-L. Hammarskjold, S.A. Goldman, H.I. Kornblum, M. Yao, F. White, H. Zong, BioRxiv
    (2026).
date_created: 2026-02-10T12:55:55Z
date_published: 2026-01-16T00:00:00Z
date_updated: 2026-02-16T10:12:42Z
day: '16'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.64898/2026.01.15.699808
has_accepted_license: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
main_file_link:
- open_access: '1'
  url: https://doi.org/10.64898/2026.01.15.699808
month: '01'
oa: 1
oa_version: Preprint
publication: bioRxiv
publication_status: published
status: public
title: Critical role of cell competition in gliomagenesis
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21230'
abstract:
- lang: eng
  text: Asteroseismology is the study of the interior physics and structure of stars
    using their pulsations. It is applicable to stars across the Hertzsprung–Russell
    (HR) diagram and a powerful technique not only to measure masses, radii, and ages
    but also directly constrain interior rotation, chemical mixing, and magnetism.
    This is because a star's self-excited pulsation modes are sensitive to its structure.
    Asteroseismology generally requires long-duration and high-precision time-series
    data. The method of forward asteroseismic modeling, which is the statistical comparison
    of observed pulsation mode frequencies to theoretically predicted pulsation frequencies
    calculated from a grid of models, provides precise constraints for calibrating
    various transport phenomena. In this introduction to asteroseismology, we provide
    an overview of its principles, and the typical data sets and methodologies used
    to constrain stellar interiors. Finally, we present key highlights of asteroseismic
    results from across the HR diagram, and conclude with ongoing challenges and future
    prospects for this ever-expanding field within stellar astrophysics.
article_processing_charge: No
arxiv: 1
author:
- first_name: Dominic M.
  full_name: Bowman, Dominic M.
  last_name: Bowman
- first_name: Lisa Annabelle
  full_name: Bugnet, Lisa Annabelle
  id: d9edb345-f866-11ec-9b37-d119b5234501
  last_name: Bugnet
  orcid: 0000-0003-0142-4000
citation:
  ama: 'Bowman DM, Bugnet LA. Asteroseismology. In: Mandel I, ed. <i>Encyclopedia
    of Astrophysics</i>. Vol 2. Elsevier; 2026:133-153. doi:<a href="https://doi.org/10.1016/b978-0-443-21439-4.00036-5">10.1016/b978-0-443-21439-4.00036-5</a>'
  apa: Bowman, D. M., &#38; Bugnet, L. A. (2026). Asteroseismology. In I. Mandel (Ed.),
    <i>Encyclopedia of Astrophysics</i> (Vol. 2, pp. 133–153). Elsevier. <a href="https://doi.org/10.1016/b978-0-443-21439-4.00036-5">https://doi.org/10.1016/b978-0-443-21439-4.00036-5</a>
  chicago: Bowman, Dominic M., and Lisa Annabelle Bugnet. “Asteroseismology.” In <i>Encyclopedia
    of Astrophysics</i>, edited by Ilya Mandel, 2:133–53. Elsevier, 2026. <a href="https://doi.org/10.1016/b978-0-443-21439-4.00036-5">https://doi.org/10.1016/b978-0-443-21439-4.00036-5</a>.
  ieee: D. M. Bowman and L. A. Bugnet, “Asteroseismology,” in <i>Encyclopedia of Astrophysics</i>,
    vol. 2, I. Mandel, Ed. Elsevier, 2026, pp. 133–153.
  ista: 'Bowman DM, Bugnet LA. 2026.Asteroseismology. In: Encyclopedia of Astrophysics.
    vol. 2, 133–153.'
  mla: Bowman, Dominic M., and Lisa Annabelle Bugnet. “Asteroseismology.” <i>Encyclopedia
    of Astrophysics</i>, edited by Ilya Mandel, vol. 2, Elsevier, 2026, pp. 133–53,
    doi:<a href="https://doi.org/10.1016/b978-0-443-21439-4.00036-5">10.1016/b978-0-443-21439-4.00036-5</a>.
  short: D.M. Bowman, L.A. Bugnet, in:, I. Mandel (Ed.), Encyclopedia of Astrophysics,
    Elsevier, 2026, pp. 133–153.
date_created: 2026-02-16T10:43:01Z
date_published: 2026-01-01T00:00:00Z
date_updated: 2026-02-17T11:05:20Z
day: '01'
department:
- _id: LiBu
doi: 10.1016/b978-0-443-21439-4.00036-5
editor:
- first_name: Ilya
  full_name: Mandel, Ilya
  last_name: Mandel
external_id:
  arxiv:
  - '2410.01715'
intvolume: '         2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2410.01715
month: '01'
oa: 1
oa_version: Preprint
page: 133-153
publication: Encyclopedia of Astrophysics
publication_identifier:
  isbn:
  - '9780443214400'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Asteroseismology
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21231'
abstract:
- lang: eng
  text: To assess cell migration in complex spatial environments, microfabricated
    chips, such as mazes and pillar forests, are routinely used to impose spatial
    and mechanical constraints, and cell trajectories are followed within these structures
    by advanced imaging techniques. In systems mechanobiology, computational models
    serve as essential tools to uncover how physical geometry influences intracellular
    dynamics; however, decoding such complex behaviors requires advanced inference
    techniques. Here, we integrated experimental observations of dendritic cell migration
    in a geometrically constrained microenvironment into a Cellular Potts model. We
    demonstrated that these spatial constraints modulate the motility dynamics, including
    speed and directional changes. We show that classical summary statistics, such
    as mean squared displacement and turning angle distributions, can resolve key
    mechanistic features but fail to extract richer spatiotemporal patterns, limiting
    accurate parameter inference. To solve this, we applied neural posterior estimation
    with in-the-loop learning of summary features. This learned summary representation
    of the data enables robust and flexible parameter inference, providing a data-driven
    framework for model calibration and advancing quantitative analysis of cell migration
    in structured microenvironments.
acknowledgement: 'This work was supported by the German Federal Ministry of Education
  and Research (BMBF) (EMUNE/031L0293C), the European Union via the ERC grant INTEGRATE,
  grant agreement number 101126146, and under Germany’s Excellence Strategy by the
  Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) (EXC 2047—390685813,
  EXC 2151—390873048, FOR5775 — 533863915, and 524747443), the University of Bonn
  via the Schlegel Professorship of J.H., and the returning experts fellowship of
  the Ministry of Innovation, Science, and Research of North-Rhine-Westphalia (AZ:
  421-8.03.03.02-137069). J.M. is a member of the Nanofabrication Facility and is
  supported by the Institute of Science and Technology Austria. E.K. acknowledges
  the TRA Life and Health (University of Bonn) as part of the Excellence Strategy
  of the federal and state governments. The authors thank Laeschkir Würthner for his
  insightful comments on the implementation of the authors’ model. The views and opinions
  expressed are those of the authors only and do not necessarily reflect those of
  the funding agencies. Parts of Fig. 1 were created using BioRender. Open Access
  funding enabled and organized by Projekt DEAL.'
article_number: '20'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Jonas
  full_name: Arruda, Jonas
  last_name: Arruda
- first_name: Emad
  full_name: Alamoudi, Emad
  last_name: Alamoudi
- first_name: Robert
  full_name: Mueller, Robert
  last_name: Mueller
- first_name: Marc
  full_name: Vaisband, Marc
  last_name: Vaisband
- first_name: Ronja
  full_name: Molkenbur, Ronja
  last_name: Molkenbur
- first_name: Jack
  full_name: Merrin, Jack
  id: 4515C308-F248-11E8-B48F-1D18A9856A87
  last_name: Merrin
  orcid: 0000-0001-5145-4609
- first_name: Eva
  full_name: Kiermaier, Eva
  last_name: Kiermaier
- first_name: Jan
  full_name: Hasenauer, Jan
  last_name: Hasenauer
citation:
  ama: Arruda J, Alamoudi E, Mueller R, et al. Simulation-based inference of cell
    migration dynamics in complex spatial environments. <i>npj Systems Biology and
    Applications</i>. 2026;12. doi:<a href="https://doi.org/10.1038/s41540-026-00648-9">10.1038/s41540-026-00648-9</a>
  apa: Arruda, J., Alamoudi, E., Mueller, R., Vaisband, M., Molkenbur, R., Merrin,
    J., … Hasenauer, J. (2026). Simulation-based inference of cell migration dynamics
    in complex spatial environments. <i>Npj Systems Biology and Applications</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41540-026-00648-9">https://doi.org/10.1038/s41540-026-00648-9</a>
  chicago: Arruda, Jonas, Emad Alamoudi, Robert Mueller, Marc Vaisband, Ronja Molkenbur,
    Jack Merrin, Eva Kiermaier, and Jan Hasenauer. “Simulation-Based Inference of
    Cell Migration Dynamics in Complex Spatial Environments.” <i>Npj Systems Biology
    and Applications</i>. Springer Nature, 2026. <a href="https://doi.org/10.1038/s41540-026-00648-9">https://doi.org/10.1038/s41540-026-00648-9</a>.
  ieee: J. Arruda <i>et al.</i>, “Simulation-based inference of cell migration dynamics
    in complex spatial environments,” <i>npj Systems Biology and Applications</i>,
    vol. 12. Springer Nature, 2026.
  ista: Arruda J, Alamoudi E, Mueller R, Vaisband M, Molkenbur R, Merrin J, Kiermaier
    E, Hasenauer J. 2026. Simulation-based inference of cell migration dynamics in
    complex spatial environments. npj Systems Biology and Applications. 12, 20.
  mla: Arruda, Jonas, et al. “Simulation-Based Inference of Cell Migration Dynamics
    in Complex Spatial Environments.” <i>Npj Systems Biology and Applications</i>,
    vol. 12, 20, Springer Nature, 2026, doi:<a href="https://doi.org/10.1038/s41540-026-00648-9">10.1038/s41540-026-00648-9</a>.
  short: J. Arruda, E. Alamoudi, R. Mueller, M. Vaisband, R. Molkenbur, J. Merrin,
    E. Kiermaier, J. Hasenauer, Npj Systems Biology and Applications 12 (2026).
date_created: 2026-02-16T10:44:31Z
date_published: 2026-02-05T00:00:00Z
date_updated: 2026-02-23T10:10:10Z
day: '05'
ddc:
- '570'
department:
- _id: NanoFab
doi: 10.1038/s41540-026-00648-9
external_id:
  pmid:
  - '41611727'
file:
- access_level: open_access
  checksum: 99b2e6bbaaedf45f22e07751948669f5
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-23T10:09:03Z
  date_updated: 2026-02-23T10:09:03Z
  file_id: '21346'
  file_name: 2026_npjSysBioApp_Arruda.pdf
  file_size: 10217687
  relation: main_file
  success: 1
file_date_updated: 2026-02-23T10:09:03Z
has_accepted_license: '1'
intvolume: '        12'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: npj Systems Biology and Applications
publication_identifier:
  eissn:
  - 2056-7189
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Simulation-based inference of cell migration dynamics in complex spatial environments
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21232'
abstract:
- lang: eng
  text: "<jats:title>Abstract</jats:title>\r\n                  <jats:p>In this paper,
    we consider a simple class of stratified spaces – 2-complexes. We present an algorithm
    that learns the abstract structure of an embedded 2-complex from a point cloud
    sampled from it. We use tools and inspiration from computational geometry, algebraic
    topology, and topological data analysis and prove the correctness of the identified
    abstract structure under assumptions on the embedding.</jats:p>"
acknowledgement: The author would like to thank Kate Turner, Chris Williams, Jonathan
  Spreer, Stephan Tillmann, Vanessa Robins, Vigleik Angeltveit, Martin Helmer, and
  James Morgan for very helpful discussions; and thanks Sara Kališnik Hintz and Paul
  Bendich for comments on an earlier version. Additonally, the author would like to
  thank both reviewers for their very insightful and helpful comments, without which
  the paper would be infinitely less coherent than it currently is. Open access funding
  provided by Institute of Science and Technology (IST Austria). The work in this
  paper was supported by an Australian Federal Government Grant, 2019-2022, Stratified
  Space Learning.
article_number: '17'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Yossi
  full_name: Bleile, Yossi
  id: 920a7385-7995-11ef-9bfd-8c434cd8f3c2
  last_name: Bleile
  orcid: 0000-0002-4861-9174
citation:
  ama: 'Bokor Bleile Y. Towards stratified space learning: 2-complexes. <i>La Matematica</i>.
    2026;5. doi:<a href="https://doi.org/10.1007/s44007-025-00183-9">10.1007/s44007-025-00183-9</a>'
  apa: 'Bokor Bleile, Y. (2026). Towards stratified space learning: 2-complexes. <i>La
    Matematica</i>. Springer Nature. <a href="https://doi.org/10.1007/s44007-025-00183-9">https://doi.org/10.1007/s44007-025-00183-9</a>'
  chicago: 'Bokor Bleile, Yossi. “Towards Stratified Space Learning: 2-Complexes.”
    <i>La Matematica</i>. Springer Nature, 2026. <a href="https://doi.org/10.1007/s44007-025-00183-9">https://doi.org/10.1007/s44007-025-00183-9</a>.'
  ieee: 'Y. Bokor Bleile, “Towards stratified space learning: 2-complexes,” <i>La
    Matematica</i>, vol. 5. Springer Nature, 2026.'
  ista: 'Bokor Bleile Y. 2026. Towards stratified space learning: 2-complexes. La
    Matematica. 5, 17.'
  mla: 'Bokor Bleile, Yossi. “Towards Stratified Space Learning: 2-Complexes.” <i>La
    Matematica</i>, vol. 5, 17, Springer Nature, 2026, doi:<a href="https://doi.org/10.1007/s44007-025-00183-9">10.1007/s44007-025-00183-9</a>.'
  short: Y. Bokor Bleile, La Matematica 5 (2026).
corr_author: '1'
date_created: 2026-02-16T10:44:44Z
date_published: 2026-02-08T00:00:00Z
date_updated: 2026-06-11T11:51:14Z
day: '08'
ddc:
- '510'
department:
- _id: HeEd
doi: 10.1007/s44007-025-00183-9
external_id:
  arxiv:
  - '2305.02724'
file:
- access_level: open_access
  checksum: 6cae2efb47b025af22a8539c606a4e09
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-23T10:18:52Z
  date_updated: 2026-02-23T10:18:52Z
  file_id: '21347'
  file_name: 2026_LaMatematica_Bleile.pdf
  file_size: 15051582
  relation: main_file
  success: 1
file_date_updated: 2026-02-23T10:18:52Z
has_accepted_license: '1'
intvolume: '         5'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
publication: La Matematica
publication_identifier:
  issn:
  - 2730-9657
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Towards stratified space learning: 2-complexes'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21234'
abstract:
- lang: eng
  text: In aged humans and mice, hypobranched glycogen aggregates, known as polyglucosan
    bodies (PGBs), accumulate in hippocampal astrocytes. While PGBs are linked to
    cognitive decline in neurological diseases, they remain largely unstudied in the
    context of typical aging. We show that PGBs arise in autophagy-dysregulated astrocytes
    in the aged hippocampus, with substantial variation among 32 inbred BXD mouse
    strains. Genetic mapping through quantitative trait locus analysis identified
    a major locus (Pgb1) that modulates hippocampal PGB burden. Extensive transcriptomic
    and proteomic datasets were produced for the aged hippocampus of the BXD family
    to investigate the mechanism by which the Pgb1 locus modulates PGB burden. We
    identified that Pgb1 contains allelic Smarcal1 and Usp37 variants and influences
    PGB burden through trans-regulation of mRNA and protein expression levels, including
    abundance of glycogen-mobilizing factor PYGB. Furthermore, comprehensive phenome-wide
    association scans, transcriptomic analyses, and direct behavioral testing demonstrated
    that cognition remains intact despite age-related PGB burden. A record of this
    paper’s transparent peer review process is included in the supplemental information.
acknowledgement: We would like to thank the Summer School Systems Genetics of Neural
  Ageing for bringing us together and spurring our international collaboration. We
  would also like to acknowledge the funding for the Summer School 2022 from the e:Med
  Systems Medicine Program of the BMBF (Bundesministerium für Bildung und Forschung;
  German Ministry of Education and Research) to R.W.O. In addition, we would like
  to thank the FLI imaging core facility for their assistance. A.G.-P. is supported
  by Fundación Séneca, Región de Murcia, Spain (21259/FPI/19). D.E.M.d.B. is financed
  by a Rubicon scholarship (452021116) from the Dutch Research Council (NWO). This
  work was also supported by NIH NIA R01AG070913-01 (R.W.W.), R01AG075813-01 (D.G.A.),
  and R01AG075818 (C.K.). We acknowledge the help of Larry Mobraaten (Jackson Laboratory,
  Bar Harbor, MN) with the BXD strains and U. Obermüller for the help with the histology.
  For the purpose of open access, the authors have applied a CC BY public copyright
  license to all author-accepted manuscripts arising from this submission.
article_number: '101488'
article_processing_charge: No
article_type: original
author:
- first_name: Alicia
  full_name: Gómez-Pascual, Alicia
  last_name: Gómez-Pascual
- first_name: Dow M
  full_name: Glikman, Dow M
  id: ab8acda1-91c1-11f0-aad8-f75d3d6424d8
  last_name: Glikman
- first_name: Hui Xin
  full_name: Ng, Hui Xin
  last_name: Ng
- first_name: James E.
  full_name: Tomkins, James E.
  last_name: Tomkins
- first_name: Lu
  full_name: Lu, Lu
  last_name: Lu
- first_name: Ying
  full_name: Xu, Ying
  last_name: Xu
- first_name: David G.
  full_name: Ashbrook, David G.
  last_name: Ashbrook
- first_name: Catherine
  full_name: Kaczorowski, Catherine
  last_name: Kaczorowski
- first_name: Gerd
  full_name: Kempermann, Gerd
  last_name: Kempermann
- first_name: John
  full_name: Killmar, John
  last_name: Killmar
- first_name: Khyobeni
  full_name: Mozhui, Khyobeni
  last_name: Mozhui
- first_name: Oliver
  full_name: Ohlenschläger, Oliver
  last_name: Ohlenschläger
- first_name: Rudolf
  full_name: Aebersold, Rudolf
  last_name: Aebersold
- first_name: Donald K.
  full_name: Ingram, Donald K.
  last_name: Ingram
- first_name: Evan G.
  full_name: Williams, Evan G.
  last_name: Williams
- first_name: Mathias
  full_name: Jucker, Mathias
  last_name: Jucker
- first_name: Rupert W.
  full_name: Overall, Rupert W.
  last_name: Overall
- first_name: Robert W.
  full_name: Williams, Robert W.
  last_name: Williams
- first_name: Dennis E.M.
  full_name: de Bakker, Dennis E.M.
  last_name: de Bakker
citation:
  ama: Gómez-Pascual A, Glikman DM, Ng HX, et al. The Smarcal1-Usp37 locus modulates
    glycogen aggregation in astrocytes of the aged hippocampus. <i>Cell Systems</i>.
    2026;17(2). doi:<a href="https://doi.org/10.1016/j.cels.2025.101488">10.1016/j.cels.2025.101488</a>
  apa: Gómez-Pascual, A., Glikman, D. M., Ng, H. X., Tomkins, J. E., Lu, L., Xu, Y.,
    … de Bakker, D. E. M. (2026). The Smarcal1-Usp37 locus modulates glycogen aggregation
    in astrocytes of the aged hippocampus. <i>Cell Systems</i>. Elsevier. <a href="https://doi.org/10.1016/j.cels.2025.101488">https://doi.org/10.1016/j.cels.2025.101488</a>
  chicago: Gómez-Pascual, Alicia, Dow M Glikman, Hui Xin Ng, James E. Tomkins, Lu
    Lu, Ying Xu, David G. Ashbrook, et al. “The Smarcal1-Usp37 Locus Modulates Glycogen
    Aggregation in Astrocytes of the Aged Hippocampus.” <i>Cell Systems</i>. Elsevier,
    2026. <a href="https://doi.org/10.1016/j.cels.2025.101488">https://doi.org/10.1016/j.cels.2025.101488</a>.
  ieee: A. Gómez-Pascual <i>et al.</i>, “The Smarcal1-Usp37 locus modulates glycogen
    aggregation in astrocytes of the aged hippocampus,” <i>Cell Systems</i>, vol.
    17, no. 2. Elsevier, 2026.
  ista: Gómez-Pascual A, Glikman DM, Ng HX, Tomkins JE, Lu L, Xu Y, Ashbrook DG, Kaczorowski
    C, Kempermann G, Killmar J, Mozhui K, Ohlenschläger O, Aebersold R, Ingram DK,
    Williams EG, Jucker M, Overall RW, Williams RW, de Bakker DEM. 2026. The Smarcal1-Usp37
    locus modulates glycogen aggregation in astrocytes of the aged hippocampus. Cell
    Systems. 17(2), 101488.
  mla: Gómez-Pascual, Alicia, et al. “The Smarcal1-Usp37 Locus Modulates Glycogen
    Aggregation in Astrocytes of the Aged Hippocampus.” <i>Cell Systems</i>, vol.
    17, no. 2, 101488, Elsevier, 2026, doi:<a href="https://doi.org/10.1016/j.cels.2025.101488">10.1016/j.cels.2025.101488</a>.
  short: A. Gómez-Pascual, D.M. Glikman, H.X. Ng, J.E. Tomkins, L. Lu, Y. Xu, D.G.
    Ashbrook, C. Kaczorowski, G. Kempermann, J. Killmar, K. Mozhui, O. Ohlenschläger,
    R. Aebersold, D.K. Ingram, E.G. Williams, M. Jucker, R.W. Overall, R.W. Williams,
    D.E.M. de Bakker, Cell Systems 17 (2026).
date_created: 2026-02-16T10:45:10Z
date_published: 2026-02-18T00:00:00Z
date_updated: 2026-02-23T10:35:01Z
day: '18'
ddc:
- '570'
department:
- _id: GradSch
doi: 10.1016/j.cels.2025.101488
external_id:
  pmid:
  - '41633365'
file:
- access_level: open_access
  checksum: 920e8edfd3b8b42f5bb6f86d4c66c54d
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-23T10:32:12Z
  date_updated: 2026-02-23T10:32:12Z
  file_id: '21349'
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  file_size: 10606778
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file_date_updated: 2026-02-23T10:32:12Z
has_accepted_license: '1'
intvolume: '        17'
issue: '2'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: Cell Systems
publication_identifier:
  issn:
  - 2405-4712
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the
  aged hippocampus
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21273'
abstract:
- lang: eng
  text: In this paper we examine how porosity fluctuations affect the hydrodynamic
    permeability of a porous matrix or membrane. We introduce a fluctuating Darcy
    model, which couples the Navier-Stokes equation to the space- and time-dependent
    porosity fluctuations via a Darcy friction term. Using a perturbative approach,
    a Dyson equation for hydrodynamic fluctuations is derived and solved to express
    the permeability in terms of the matrix fluctuation spectrum. Surprisingly, the
    model reveals strong modifications of the fluid permeability in fluctuating matrices
    compared to static ones. Applications to various matrix excitation models, the
    breathing matrix, phonons, and active forcing, highlight the significant influence
    of matrix fluctuations on fluid transport, offering insights for optimizing membrane
    design for separation applications.
acknowledgement: "The authors acknowledge support from ERC project n-AQUA, Grant Agreement
  No. 101071937.\r\nB.C. and A.S. acknowledge support from the CFM Foundation. B.C.
  acknowledges support from\r\nthe NOMIS Foundation."
article_number: '014201'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Albert
  full_name: Dombret, Albert
  last_name: Dombret
- first_name: Adrien
  full_name: Sutter, Adrien
  last_name: Sutter
- first_name: Baptiste
  full_name: Coquinot, Baptiste
  id: f8417bd4-f599-11ee-a482-b927e3ed1e8e
  last_name: Coquinot
  orcid: 0000-0001-5524-596X
- first_name: Nikita
  full_name: Kavokine, Nikita
  last_name: Kavokine
- first_name: Benoit
  full_name: Coasne, Benoit
  last_name: Coasne
- first_name: Lydéric
  full_name: Bocquet, Lydéric
  last_name: Bocquet
citation:
  ama: Dombret A, Sutter A, Coquinot B, Kavokine N, Coasne B, Bocquet L. Hydrodynamic
    permeability of fluctuating porous membranes. <i>Physical Review Fluids</i>. 2026;11(1).
    doi:<a href="https://doi.org/10.1103/m8h6-1wfk">10.1103/m8h6-1wfk</a>
  apa: Dombret, A., Sutter, A., Coquinot, B., Kavokine, N., Coasne, B., &#38; Bocquet,
    L. (2026). Hydrodynamic permeability of fluctuating porous membranes. <i>Physical
    Review Fluids</i>. American Physical Society. <a href="https://doi.org/10.1103/m8h6-1wfk">https://doi.org/10.1103/m8h6-1wfk</a>
  chicago: Dombret, Albert, Adrien Sutter, Baptiste Coquinot, Nikita Kavokine, Benoit
    Coasne, and Lydéric Bocquet. “Hydrodynamic Permeability of Fluctuating Porous
    Membranes.” <i>Physical Review Fluids</i>. American Physical Society, 2026. <a
    href="https://doi.org/10.1103/m8h6-1wfk">https://doi.org/10.1103/m8h6-1wfk</a>.
  ieee: A. Dombret, A. Sutter, B. Coquinot, N. Kavokine, B. Coasne, and L. Bocquet,
    “Hydrodynamic permeability of fluctuating porous membranes,” <i>Physical Review
    Fluids</i>, vol. 11, no. 1. American Physical Society, 2026.
  ista: Dombret A, Sutter A, Coquinot B, Kavokine N, Coasne B, Bocquet L. 2026. Hydrodynamic
    permeability of fluctuating porous membranes. Physical Review Fluids. 11(1), 014201.
  mla: Dombret, Albert, et al. “Hydrodynamic Permeability of Fluctuating Porous Membranes.”
    <i>Physical Review Fluids</i>, vol. 11, no. 1, 014201, American Physical Society,
    2026, doi:<a href="https://doi.org/10.1103/m8h6-1wfk">10.1103/m8h6-1wfk</a>.
  short: A. Dombret, A. Sutter, B. Coquinot, N. Kavokine, B. Coasne, L. Bocquet, Physical
    Review Fluids 11 (2026).
corr_author: '1'
date_created: 2026-02-17T08:10:09Z
date_published: 2026-01-21T00:00:00Z
date_updated: 2026-02-23T12:01:57Z
day: '21'
department:
- _id: MiLe
doi: 10.1103/m8h6-1wfk
external_id:
  arxiv:
  - '2512.11368'
intvolume: '        11'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2512.11368
month: '01'
oa: 1
oa_version: Preprint
publication: Physical Review Fluids
publication_identifier:
  eissn:
  - 2469-990X
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Hydrodynamic permeability of fluctuating porous membranes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21274'
abstract:
- lang: eng
  text: "Many white dwarfs are observed in compact double white dwarf binaries, and
    through the emission of gravitational waves, a large fraction are destined to
    merge. The merger remnants that do not explode in a Type Ia supernova are expected
    to initially be rapidly rotating and highly magnetized. In this work, we present
    our discovery of the variable white dwarf ZTF J200832.79+444939.67, hereafter
    ZTF J2008+4449, as a likely merger remnant showing signs of circumstellar material
    without a stellar or substellar companion. The nature of ZTF J2008+4449 as a merger
    remnant is supported by its physical properties: it is hot (35 500 ± 300 K) and
    massive (1.12 ± 0.03 M\r\n                    <jats:sub>⊙</jats:sub>\r\n                    ),
    rapidly rotating with a period of ≈6.6 minutes, and likely possesses exceptionally
    strong magnetic fields (∼400−600 MG) at its surface. Remarkably, we detect a significant
    period derivative of (1.80 ± 0.09)×10\r\n                    <jats:sup>−12</jats:sup>\r\n
    \                   s/s, indicating that the white dwarf is spinning down, and
    a soft X-ray emission that is inconsistent with photospheric emission. As the
    presence of a mass-transferring stellar or brown dwarf companion is excluded by
    infrared photometry, the detected spin-down and X-ray emission could be tell-tale
    signs of a magnetically driven wind or of interaction with circumstellar material,
    possibly originating from the fallback of gravitationally bound merger ejecta
    or from the tidal disruption of a planetary object. We also detect Balmer emission,
    which requires the presence of ionized hydrogen in the vicinity of the white dwarf,
    showing Doppler shifts as high as ≈2000 km s\r\n                    <jats:sup>−1</jats:sup>\r\n
    \                   . The unusual variability of the Balmer emission on the spin
    period of the white dwarf is consistent with the trapping of a half ring of ionized
    gas in the magnetosphere of the white dwarf.\r\n                  </jats:p>"
acknowledgement: "We thank Lynne Hillenbrand and Soumyadeep Bhattacharjee for helpful
  discussions, and Kishalay De for his help with the WIRC\r\nreduction pipeline. IC
  was supported by NASA through grants from the Space\r\nTelescope Science Institute,
  under NASA contracts NASA.22K1813, NAS5-\r\n26555 and NAS5-03127. TC was supported
  by NASA through the NASA Hubble\r\nFellowship grant HST-HF2-51527.001-A awarded
  by the Space Telescope Science Institute, which is operated by the Association of
  Universities for Research\r\nin Astronomy, Inc., for NASA, under contract NAS5-26555.
  This project has\r\nreceived funding from the European Research Council (ERC) under
  the European Union’s Horizon 2020 research and innovation programme (Grant agreement
  No. 101020057). This work was based on observations obtained with the\r\nSamuel
  Oschin Telescope 48-inch and the 60-inch Telescope at the Palomar\r\nObservatory
  as part of the Zwicky Transient Facility project. ZTF is supported\r\nby the National
  Science Foundation under Grants No. AST-1440341, AST2034437, and currently Award
  #2407588. ZTF receives additional funding from\r\nthe ZTF partnership. Current members
  include Caltech, USA; Caltech/IPAC,\r\nUSA; University of Maryland, USA; University
  of California, Berkeley, USA;\r\nUniversity of Wisconsin at Milwaukee, USA; Cornell
  University, USA; Drexel\r\nUniversity, USA; University of North Carolina at Chapel
  Hill, USA; Institute\r\nof Science and Technology, Austria; National Central University,
  Taiwan, and\r\nOKC, University of Stockholm, Sweden. Operations are conducted by
  Caltech’s\r\nOptical Observatory (COO), Caltech/IPAC, and the University of Washington
  at\r\nSeattle, USA. This work has made use of data from the European Space Agency\r\n(ESA)
  mission Gaia (https://www.cosmos.esa.int/gaia), processed by\r\nthe Gaia Data Processing
  and Analysis Consortium (DPAC, https://www.\r\ncosmos.esa.int/web/gaia/dpac/consortium).
  Funding for the DPAC has been provided by national institutions, in particular the
  institutions participating in the Gaia Multilateral Agreement. The Pan-STARRS1 Surveys
  (PS1)\r\nand the PS1 public science archive have been made possible through contributions
  by the Institute for Astronomy, the University of Hawaii, the PanSTARRS Project
  Office, the Max-Planck Society and its participating institutes, the Max Planck
  Institute for Astronomy, Heidelberg and the Max Planck\r\nInstitute for Extraterrestrial
  Physics, Garching, The Johns Hopkins University,\r\nDurham University, the University
  of Edinburgh, the Queen’s University Belfast,\r\nthe Harvard-Smithsonian Center
  for Astrophysics, the Las Cumbres Observatory Global Telescope Network Incorporated,
  the National Central University of Taiwan, the Space Telescope Science Institute,
  the National Aeronautics and Space Administration under Grant No. NNX08AR22G issued
  through\r\nthe Planetary Science Division of the NASA Science Mission Directorate,
  the\r\nNational Science Foundation Grant No. AST–1238877, the University of Maryland,
  Eotvos Lorand University (ELTE), the Los Alamos National Laboratory,\r\nand the
  Gordon and Betty Moore Foundation. This work made use of Astropy\r\n(http://www.astropy.org):
  a community-developed core Python package\r\nand an ecosystem of tools and resources
  for astronomy (Astropy Collaboration\r\n2013, 2018, 2022)."
article_number: A188
article_processing_charge: Yes
article_type: original
author:
- first_name: Andrei-Alexandru
  full_name: Cristea, Andrei-Alexandru
  id: 4d500bea-31f8-11ee-a48d-d4904fb363c7
  last_name: Cristea
- first_name: Ilaria
  full_name: Caiazzo, Ilaria
  id: 8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d
  last_name: Caiazzo
  orcid: 0000-0002-4770-5388
- first_name: Tim
  full_name: Cunningham, Tim
  last_name: Cunningham
- first_name: John C.
  full_name: Raymond, John C.
  last_name: Raymond
- first_name: Stephane
  full_name: Vennes, Stephane
  last_name: Vennes
- first_name: Adela
  full_name: Kawka, Adela
  last_name: Kawka
- first_name: Aayush A
  full_name: Desai, Aayush A
  id: 502cfd30-32c1-11ee-a9a4-d8dad5c6739e
  last_name: Desai
- first_name: David R.
  full_name: Miller, David R.
  last_name: Miller
- first_name: J. J.
  full_name: Hermes, J. J.
  last_name: Hermes
- first_name: Jim
  full_name: Fuller, Jim
  last_name: Fuller
- first_name: Jeremy
  full_name: Heyl, Jeremy
  last_name: Heyl
- first_name: Jan
  full_name: van Roestel, Jan
  last_name: van Roestel
- first_name: Kevin B.
  full_name: Burdge, Kevin B.
  last_name: Burdge
- first_name: Antonio C.
  full_name: Rodriguez, Antonio C.
  last_name: Rodriguez
- first_name: Ingrid
  full_name: Pelisoli, Ingrid
  last_name: Pelisoli
- first_name: Boris T.
  full_name: Gänsicke, Boris T.
  last_name: Gänsicke
- first_name: Paula
  full_name: Szkody, Paula
  last_name: Szkody
- first_name: Scott J.
  full_name: Kenyon, Scott J.
  last_name: Kenyon
- first_name: Zach
  full_name: Vanderbosch, Zach
  last_name: Vanderbosch
- first_name: Andrew
  full_name: Drake, Andrew
  last_name: Drake
- first_name: Lilia
  full_name: Ferrario, Lilia
  last_name: Ferrario
- first_name: Dayal
  full_name: Wickramasinghe, Dayal
  last_name: Wickramasinghe
- first_name: Viraj R.
  full_name: Karambelkar, Viraj R.
  last_name: Karambelkar
- first_name: Stephen
  full_name: Justham, Stephen
  last_name: Justham
- first_name: Ruediger
  full_name: Pakmor, Ruediger
  last_name: Pakmor
- first_name: Kareem
  full_name: El-Badry, Kareem
  last_name: El-Badry
- first_name: Thomas
  full_name: Prince, Thomas
  last_name: Prince
- first_name: S. R.
  full_name: Kulkarni, S. R.
  last_name: Kulkarni
- first_name: Matthew J.
  full_name: Graham, Matthew J.
  last_name: Graham
- first_name: Frank J.
  full_name: Masci, Frank J.
  last_name: Masci
- first_name: Steven L.
  full_name: Groom, Steven L.
  last_name: Groom
- first_name: Josiah
  full_name: Purdum, Josiah
  last_name: Purdum
- first_name: Richard
  full_name: Dekany, Richard
  last_name: Dekany
- first_name: Eric C.
  full_name: Bellm, Eric C.
  last_name: Bellm
citation:
  ama: Cristea A-A, Caiazzo I, Cunningham T, et al. A half ring of ionized circumstellar
    material trapped in the magnetosphere of a white dwarf merger remnant. <i>Astronomy
    &#38; Astrophysics</i>. 2026;706. doi:<a href="https://doi.org/10.1051/0004-6361/202556432">10.1051/0004-6361/202556432</a>
  apa: Cristea, A.-A., Caiazzo, I., Cunningham, T., Raymond, J. C., Vennes, S., Kawka,
    A., … Bellm, E. C. (2026). A half ring of ionized circumstellar material trapped
    in the magnetosphere of a white dwarf merger remnant. <i>Astronomy &#38; Astrophysics</i>.
    EDP Sciences. <a href="https://doi.org/10.1051/0004-6361/202556432">https://doi.org/10.1051/0004-6361/202556432</a>
  chicago: Cristea, Andrei-Alexandru, Ilaria Caiazzo, Tim Cunningham, John C. Raymond,
    Stephane Vennes, Adela Kawka, Aayush A Desai, et al. “A Half Ring of Ionized Circumstellar
    Material Trapped in the Magnetosphere of a White Dwarf Merger Remnant.” <i>Astronomy
    &#38; Astrophysics</i>. EDP Sciences, 2026. <a href="https://doi.org/10.1051/0004-6361/202556432">https://doi.org/10.1051/0004-6361/202556432</a>.
  ieee: A.-A. Cristea <i>et al.</i>, “A half ring of ionized circumstellar material
    trapped in the magnetosphere of a white dwarf merger remnant,” <i>Astronomy &#38;
    Astrophysics</i>, vol. 706. EDP Sciences, 2026.
  ista: Cristea A-A, Caiazzo I, Cunningham T, Raymond JC, Vennes S, Kawka A, Desai
    AA, Miller DR, Hermes JJ, Fuller J, Heyl J, van Roestel J, Burdge KB, Rodriguez
    AC, Pelisoli I, Gänsicke BT, Szkody P, Kenyon SJ, Vanderbosch Z, Drake A, Ferrario
    L, Wickramasinghe D, Karambelkar VR, Justham S, Pakmor R, El-Badry K, Prince T,
    Kulkarni SR, Graham MJ, Masci FJ, Groom SL, Purdum J, Dekany R, Bellm EC. 2026.
    A half ring of ionized circumstellar material trapped in the magnetosphere of
    a white dwarf merger remnant. Astronomy &#38; Astrophysics. 706, A188.
  mla: Cristea, Andrei-Alexandru, et al. “A Half Ring of Ionized Circumstellar Material
    Trapped in the Magnetosphere of a White Dwarf Merger Remnant.” <i>Astronomy &#38;
    Astrophysics</i>, vol. 706, A188, EDP Sciences, 2026, doi:<a href="https://doi.org/10.1051/0004-6361/202556432">10.1051/0004-6361/202556432</a>.
  short: A.-A. Cristea, I. Caiazzo, T. Cunningham, J.C. Raymond, S. Vennes, A. Kawka,
    A.A. Desai, D.R. Miller, J.J. Hermes, J. Fuller, J. Heyl, J. van Roestel, K.B.
    Burdge, A.C. Rodriguez, I. Pelisoli, B.T. Gänsicke, P. Szkody, S.J. Kenyon, Z.
    Vanderbosch, A. Drake, L. Ferrario, D. Wickramasinghe, V.R. Karambelkar, S. Justham,
    R. Pakmor, K. El-Badry, T. Prince, S.R. Kulkarni, M.J. Graham, F.J. Masci, S.L.
    Groom, J. Purdum, R. Dekany, E.C. Bellm, Astronomy &#38; Astrophysics 706 (2026).
corr_author: '1'
date_created: 2026-02-17T08:12:05Z
date_published: 2026-02-10T00:00:00Z
date_updated: 2026-04-28T12:01:21Z
day: '10'
ddc:
- '520'
department:
- _id: IlCa
- _id: GradSch
doi: 10.1051/0004-6361/202556432
file:
- access_level: open_access
  checksum: 229b688e6e78cab5bb8e2bac366d1575
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-23T12:04:37Z
  date_updated: 2026-02-23T12:04:37Z
  file_id: '21350'
  file_name: 2026_AstronomyAstrophysics_Cristea.pdf
  file_size: 5352853
  relation: main_file
  success: 1
file_date_updated: 2026-02-23T12:04:37Z
has_accepted_license: '1'
intvolume: '       706'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
publication: Astronomy & Astrophysics
publication_identifier:
  eissn:
  - 1432-0746
  issn:
  - 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
related_material:
  link:
  - description: News on ISTA website
    relation: press_release
    url: https://ista.ac.at/en/news/twos-company-new-class-of-star-remnants/
status: public
title: A half ring of ionized circumstellar material trapped in the magnetosphere
  of a white dwarf merger remnant
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 706
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21275'
abstract:
- lang: eng
  text: DNA methylation is a primary layer of epigenetic modification that plays a
    pivotal role in the regulation of development, aging, and cancer. The concurrent
    activity of opposing enzymes that mediate DNA methylation and demethylation gives
    rise to a biochemical cycle and active turnover of DNA methylation. While the
    ensuing biochemical oscillations have been implicated in the regulation of cell
    differentiation, their functional role and spatiotemporal dynamics are unknown.
    In this work, we demonstrate that chromatin-mediated coupling between these local
    biochemical cycles can lead to the emergence of phase-locked domains, regions
    of locally synchronized turnover activity, whose coarsening is arrested by genomic
    heterogeneity. We introduce a minimal model based on stochastic oscillators with
    constrained long-range and nonreciprocal interactions, shaped by the local chromatin
    organization. Through a combination of analytical theory and stochastic simulations,
    we predict both the degree of synchronization and the typical size of emergent
    phase-locked domains. We qualitatively test these predictions using single-cell
    sequencing data. Our results show that DNA methylation turnover exhibits surprisingly
    rich spatiotemporal patterns that may be used by cells to control cell differentiation.
acknowledgement: This project has received funding from the European Union's Horizon
  2020 research and innovation programme under Grant Agreement No. 950349 and the
  Marie Skłodowska-Curie Grant Agreement No. 101034413. The computations in this paper
  were run in part on the the FASRC Cannon cluster supported by the FAS Division of
  Science Research Computing Group at Harvard University and the cluster of the Max
  Planck Institute for the Physics of Complex Systems.
article_number: '013018'
article_processing_charge: Yes
article_type: original
author:
- first_name: Fabrizio
  full_name: Olmeda, Fabrizio
  id: 69dbf5fb-8a76-11ed-866b-fb486d8b5689
  last_name: Olmeda
- first_name: Misha
  full_name: Gupta, Misha
  last_name: Gupta
- first_name: Onurcan
  full_name: Bektas, Onurcan
  last_name: Bektas
- first_name: Steffen
  full_name: Rulands, Steffen
  last_name: Rulands
citation:
  ama: Olmeda F, Gupta M, Bektas O, Rulands S. Spatiotemporal patterns of active epigenetic
    turnover. <i>PRX Life</i>. 2026;4. doi:<a href="https://doi.org/10.1103/89bj-79g5">10.1103/89bj-79g5</a>
  apa: Olmeda, F., Gupta, M., Bektas, O., &#38; Rulands, S. (2026). Spatiotemporal
    patterns of active epigenetic turnover. <i>PRX Life</i>. American Physical Society.
    <a href="https://doi.org/10.1103/89bj-79g5">https://doi.org/10.1103/89bj-79g5</a>
  chicago: Olmeda, Fabrizio, Misha Gupta, Onurcan Bektas, and Steffen Rulands. “Spatiotemporal
    Patterns of Active Epigenetic Turnover.” <i>PRX Life</i>. American Physical Society,
    2026. <a href="https://doi.org/10.1103/89bj-79g5">https://doi.org/10.1103/89bj-79g5</a>.
  ieee: F. Olmeda, M. Gupta, O. Bektas, and S. Rulands, “Spatiotemporal patterns of
    active epigenetic turnover,” <i>PRX Life</i>, vol. 4. American Physical Society,
    2026.
  ista: Olmeda F, Gupta M, Bektas O, Rulands S. 2026. Spatiotemporal patterns of active
    epigenetic turnover. PRX Life. 4, 013018.
  mla: Olmeda, Fabrizio, et al. “Spatiotemporal Patterns of Active Epigenetic Turnover.”
    <i>PRX Life</i>, vol. 4, 013018, American Physical Society, 2026, doi:<a href="https://doi.org/10.1103/89bj-79g5">10.1103/89bj-79g5</a>.
  short: F. Olmeda, M. Gupta, O. Bektas, S. Rulands, PRX Life 4 (2026).
corr_author: '1'
date_created: 2026-02-17T08:17:53Z
date_published: 2026-02-09T00:00:00Z
date_updated: 2026-02-24T06:54:32Z
day: '09'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1103/89bj-79g5
ec_funded: 1
file:
- access_level: open_access
  checksum: df9776422862d1d02c66d98e2d620849
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-24T06:53:05Z
  date_updated: 2026-02-24T06:53:05Z
  file_id: '21351'
  file_name: 2026_PRXLife_Olmeda.pdf
  file_size: 5857833
  relation: main_file
  success: 1
file_date_updated: 2026-02-24T06:53:05Z
has_accepted_license: '1'
intvolume: '         4'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
publication: PRX Life
publication_identifier:
  eissn:
  - 2835-8279
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Spatiotemporal patterns of active epigenetic turnover
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21282'
abstract:
- lang: eng
  text: 'Developmental patterning comprises processes that range from purely instructed,
    where external signals specify cell fates, to fully self-organized, where spatial
    patterns emerge autonomously through cellular interactions. We propose that both
    extremes—as well as the continuum of intermediate cases—can be conceptualized
    as information-processing systems, whose operation can be described using “Marr''s
    three levels of analysis”: the computational problem being solved, the algorithms
    employed, and their molecular implementation. At the first level, we argue that
    normative theories, such as information-theoretic optimization principles, provide
    a formalization of the computational problem. At the second level, we show how
    simplified information-processing architectures provide a framework for developmental
    algorithms, which are formalized mathematically using dynamical systems theory.
    At the third level, the implementation of developmental algorithms is described
    by mechanistic biophysical and gene regulatory network models.'
acknowledgement: We thank Edouard Hannezo, Anna Kicheva, Fridtjof Brauns, and all
  members of the Brückner and Tkačik groups for feedback and inspiring discussions.
  This work was supported in part by European Research Council ERC-2023-SyG “Dynatrans”
  Grant No. 101118866 (G.T.). This work was conducted while visiting the Okinawa Institute
  of Science and Technology (OIST) through the Theoretical Sciences Visiting Program
  (TSVP); at the Kavli Institute for Theoretical Physics (KITP) Santa Barbara, supported
  by NSF Grant No. PHY-1748958 and the Gordon and Betty Moore Foundation Grant No.
  2919.02; and at Lucullus, Vienna.
article_number: '017001'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: David
  full_name: Brückner, David
  id: e1e86031-6537-11eb-953a-f7ab92be508d
  last_name: Brückner
  orcid: 0000-0001-7205-2975
- first_name: Gašper
  full_name: Tkačik, Gašper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkačik
  orcid: 0000-0002-6699-1455
citation:
  ama: 'Brückner D, Tkačik G. Marr’s three levels for embryonic development: Information,
    dynamical systems, gene networks. <i>PRX Life</i>. 2026;4. doi:<a href="https://doi.org/10.1103/fdcf-dkws">10.1103/fdcf-dkws</a>'
  apa: 'Brückner, D., &#38; Tkačik, G. (2026). Marr’s three levels for embryonic development:
    Information, dynamical systems, gene networks. <i>PRX Life</i>. American Physical
    Society. <a href="https://doi.org/10.1103/fdcf-dkws">https://doi.org/10.1103/fdcf-dkws</a>'
  chicago: 'Brückner, David, and Gašper Tkačik. “Marr’s Three Levels for Embryonic
    Development: Information, Dynamical Systems, Gene Networks.” <i>PRX Life</i>.
    American Physical Society, 2026. <a href="https://doi.org/10.1103/fdcf-dkws">https://doi.org/10.1103/fdcf-dkws</a>.'
  ieee: 'D. Brückner and G. Tkačik, “Marr’s three levels for embryonic development:
    Information, dynamical systems, gene networks,” <i>PRX Life</i>, vol. 4. American
    Physical Society, 2026.'
  ista: 'Brückner D, Tkačik G. 2026. Marr’s three levels for embryonic development:
    Information, dynamical systems, gene networks. PRX Life. 4, 017001.'
  mla: 'Brückner, David, and Gašper Tkačik. “Marr’s Three Levels for Embryonic Development:
    Information, Dynamical Systems, Gene Networks.” <i>PRX Life</i>, vol. 4, 017001,
    American Physical Society, 2026, doi:<a href="https://doi.org/10.1103/fdcf-dkws">10.1103/fdcf-dkws</a>.'
  short: D. Brückner, G. Tkačik, PRX Life 4 (2026).
corr_author: '1'
date_created: 2026-02-17T08:29:10Z
date_published: 2026-01-23T00:00:00Z
date_updated: 2026-02-24T07:00:16Z
day: '23'
ddc:
- '570'
department:
- _id: GaTk
doi: 10.1103/fdcf-dkws
external_id:
  arxiv:
  - '2510.24536'
file:
- access_level: open_access
  checksum: 99ef02dd741c4536eeefd12d409d5269
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-24T06:57:44Z
  date_updated: 2026-02-24T06:57:44Z
  file_id: '21352'
  file_name: 2026_PRXLife_Brueckner.pdf
  file_size: 1147994
  relation: main_file
  success: 1
file_date_updated: 2026-02-24T06:57:44Z
has_accepted_license: '1'
intvolume: '         4'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 7bfe6a29-9f16-11ee-852c-c0da5e2045d9
  grant_number: '101118866'
  name: 'Transcription in 4D: the dynamic interplay between chromatin architecture
    and gene expression in developing pseudo-embryos'
publication: PRX Life
publication_identifier:
  eissn:
  - 2835-8279
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: 'Marr''s three levels for embryonic development: Information, dynamical systems,
  gene networks'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2026'
...
---
OA_place: repository
OA_type: free access
_id: '21284'
abstract:
- lang: eng
  text: The advantageous characteristics attributed to the 19F nucleus have made it
    a popular target for NMR once again in recent years. Aside from solution NMR,
    an increasing number of studies have been conducted applying solid-state magic-angle-spinning
    NMR to fluorine-labeled samples. Here, the high chemical shift anisotropy and
    strong dipolar couplings can be utilized to get structural insights into proteins
    and measure long distances. Despite increasing popularity and promising benefits,
    the sensitivity of biomolecular 19F MAS NMR often suffers from slow longitudinal
    T1 relaxation and therefore long recycle delays. In this work, we expand paramagnetic
    doping, an approach commonly used to reduce proton T1 relaxation times, to 19F-labeled
    biological samples. We study the effect of Gd(DTPA) and Gd(DTPA-BMA) on 19F and
    13C T1 and T2 relaxation in a [5-19F13C]-tryptophan-labeled protein via 19F-detected
    MAS NMR experiments. The observed paramagnetic relaxation enhancement substantially
    reduces measurement times of 19F MAS NMR experiments without compromising resolution.
    Additionally, we report the chemical-shift assignments of all four fluorotryptophan
    signals in the 12 × 39 kDa large protein using a mutagenesis approach.
acknowledged_ssus:
- _id: NMR
- _id: LifeSc
acknowledgement: We thank Ben P. Tatman for insightful discussions. This research
  was supported by the Scientific Service Units (SSU) of Institute of Science and
  Technology Austria (ISTA) through resources provided by the Nuclear Magnetic Resonance
  Facility and the Lab Support Facility.
article_processing_charge: No
author:
- first_name: Lea Marie
  full_name: Becker, Lea Marie
  id: 36336939-eb97-11eb-a6c2-c83f1214ca79
  last_name: Becker
  orcid: 0000-0002-6401-5151
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
citation:
  ama: Becker LM, Schanda P. Research data for “Accelerated 19F biomolecular magic-angle
    spinning NMR with paramagnetic dopants.” 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-21284">10.15479/AT-ISTA-21284</a>
  apa: Becker, L. M., &#38; Schanda, P. (2026). Research data for “Accelerated 19F
    biomolecular magic-angle spinning NMR with paramagnetic dopants.” Institute of
    Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-21284">https://doi.org/10.15479/AT-ISTA-21284</a>
  chicago: Becker, Lea Marie, and Paul Schanda. “Research Data for ‘Accelerated 19F
    Biomolecular Magic-Angle Spinning NMR with Paramagnetic Dopants.’” Institute of
    Science and Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-21284">https://doi.org/10.15479/AT-ISTA-21284</a>.
  ieee: L. M. Becker and P. Schanda, “Research data for ‘Accelerated 19F biomolecular
    magic-angle spinning NMR with paramagnetic dopants.’” Institute of Science and
    Technology Austria, 2026.
  ista: Becker LM, Schanda P. 2026. Research data for ‘Accelerated 19F biomolecular
    magic-angle spinning NMR with paramagnetic dopants’, Institute of Science and
    Technology Austria, <a href="https://doi.org/10.15479/AT-ISTA-21284">10.15479/AT-ISTA-21284</a>.
  mla: Becker, Lea Marie, and Paul Schanda. <i>Research Data for “Accelerated 19F
    Biomolecular Magic-Angle Spinning NMR with Paramagnetic Dopants.”</i> Institute
    of Science and Technology Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-21284">10.15479/AT-ISTA-21284</a>.
  short: L.M. Becker, P. Schanda, (2026).
contributor:
- contributor_type: researcher
  first_name: Giorgia
  id: 334a5e40-8747-11f0-b671-ba1f5154b4b4
  last_name: Toscano
- contributor_type: researcher
  first_name: Anna
  id: 9fb2a840-89e1-11ee-a8b7-cc5c7ba62471
  last_name: Kapitonova
- contributor_type: researcher
  first_name: Rajkumar
  id: a3089acd-6806-11ee-bacc-f0c7d500ad20
  last_name: Singh
- contributor_type: researcher
  first_name: Undina
  id: bb74f472-ae54-11eb-9835-bc9c22fb1183
  last_name: Guillerm
- contributor_type: researcher
  first_name: Roman
  last_name: Lichtenecker
corr_author: '1'
date_created: 2026-02-17T10:17:14Z
date_published: 2026-02-18T00:00:00Z
date_updated: 2026-06-10T09:28:41Z
day: '18'
ddc:
- '541'
department:
- _id: GradSch
- _id: PaSc
doi: 10.15479/AT-ISTA-21284
file:
- access_level: open_access
  checksum: 2d3105f26be578073b88ee1f2ea0bdb1
  content_type: application/zip
  creator: lbecker
  date_created: 2026-02-17T10:11:14Z
  date_updated: 2026-02-17T10:11:14Z
  file_id: '21285'
  file_name: Research_data.zip
  file_size: 36996027
  relation: main_file
  success: 1
- access_level: open_access
  checksum: e24aebcdb8856cb181cbaa02de020ddb
  content_type: text/plain
  creator: lbecker
  date_created: 2026-02-17T10:11:14Z
  date_updated: 2026-02-17T10:11:14Z
  file_id: '21286'
  file_name: README.txt
  file_size: 1993
  relation: table_of_contents
file_date_updated: 2026-02-17T10:11:14Z
has_accepted_license: '1'
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '2'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
status: public
title: Research data for "Accelerated 19F biomolecular magic-angle spinning NMR with
  paramagnetic dopants"
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: research_data
user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21290'
abstract:
- lang: eng
  text: Gene duplication underlies evolutionary innovation, yet many paralogues remain
    highly similar, raising questions about their functional divergence and physiological
    relevance. The spliceosomal Sm core protein SNRPB and its mammalian-specific paralogue
    SNRPN share over 90% sequence identity, but their distinct expression patterns
    - SNRPB being ubiquitous and SNRPN confined to the brain - suggest specialized
    functions. Why mammals have two different spliceosomes has remained obscure. Here,
    we generated isogenic human cell lines expressing ectopically either SNRPB or
    SNRPN exclusively and found that SNRPN stabilizes transcripts involved in energy
    metabolism and mitochondrial function, leading to increased mitochondrial abundance
    and oxygen consumption. Despite similar spliceosomal interactomes, SNRPN more
    strongly associates with the PRMT5 methylosome complex and exhibits dynamic arginine
    methylation in its C-terminal region that is sensitive to translation inhibition
    and amino acid availability. The SNRPN-dependent transcriptome responds to translation
    inhibition by stabilizing long, intron-rich genes involved in amino acid and energy
    metabolism. Our findings reveal a nutrient-sensitive, methylation-dependent mechanism
    that differentiates the two paralogues. This suggests that SNRPN functions as
    a metabolic-specialized spliceosomal subunit thereby providing tissue-specific
    adaptation of RNA processing in mammals.
acknowledgement: "We thank Oliver Mühlemann and Alex Hofer (University of Bern) for
  sharing SMG inhibitors\r\nand for their expertise in nonsense-mediated mRNA decay
  and Maria Hondele for critical\r\nreading of the manuscript draft. We also thank
  the IMB Genomics Core Facility for assistance\r\nwith library preparation and sequencing,
  Martin Möckel and the IMB Protein Production Core\r\nFacility for providing enzymes
  used in this work, Marton Gelleri together with the IMB\r\nMicroscopy Core Facility
  for support with microscopy and FRAP experiments, Jasmin Cartano\r\nfor proteomics
  sample processing and the IMB Flow Cytometry Core Facility for support. In\r\naddition,
  we thank the Imaging Core Facility (IMCF) and the FACS Core Facility at the\r\nBiozentrum,
  University of Basel, for technical assistance. CIKV acknowledges funding by the\r\nDeutsche
  Forschungsgemeinschaft (DFG, German Research Foundation) - Individual Grant\r\nProject
  no. 513744403, Scientific Network Grant Project no. 531902894, GRK2526 “Genevo”\r\n-
  Project no. 407023052”, GRK2859 (“4R”) - Project no. 491145305, Forschungsinitiative\r\nRheinland-Pfalz
  (ReALity), the EMBO Young Investigator Program (5795), institutional\r\nfunding
  from the Institute of Molecular Biology and funds from the Kanton Basel-Stadt and\r\nBasel-Land
  provided to the Biozentrum of the University Basel. J.H.G.F.G. was part of the\r\n‘Science
  of Healthy Ageing Research Programme’ (SHARP) initiative funded by RhinelandPalatinate’s
  Ministry of Science, Education and Culture. PR is funded by the Biozentrum PhD\r\nFellowships
  Program. MFB received financial support from the intramural High Potentials\r\nGrant
  program of the University Medical Center Mainz, Forschungsinitiative Rheinland-Pfalz\r\n(ReALity)
  and Stiftungen zugunsten der Medizinischen Fakultät der LMU Klinikum (26069).\r\nInstruments
  in the IMB core facilities were supported by funds from the DFG: Laser Scanning\r\nConfocal
  (Leica Stellaris 8 Falcon, funded by the DFG - Project #497669232), Orbitrap Astral
  system (funded by the DFG - Project #524805621) and BD LSRFortessa SOPR is funded
  by\r\nthe DFG - Project #210253511.\r\n"
article_processing_charge: No
author:
- first_name: Feyza
  full_name: Polat Haas, Feyza
  last_name: Polat Haas
- first_name: Ana
  full_name: Villalba Requena, Ana
  id: 68cb85a0-39f7-11eb-9559-9aaab4f6a247
  last_name: Villalba Requena
  orcid: 0000-0002-5615-5277
- first_name: Polina
  full_name: Rusina, Polina
  last_name: Rusina
- first_name: Anusha
  full_name: Gopalan, Anusha
  last_name: Gopalan
- first_name: Hector
  full_name: Fritz, Hector
  last_name: Fritz
- first_name: Azamat
  full_name: Akhmetkaliyev, Azamat
  last_name: Akhmetkaliyev
- first_name: Frank
  full_name: Ruehle, Frank
  last_name: Ruehle
- first_name: Anna
  full_name: Einsiedel, Anna
  last_name: Einsiedel
- first_name: Anna
  full_name: Szczepinska, Anna
  last_name: Szczepinska
- first_name: Fridolin
  full_name: Kielisch, Fridolin
  last_name: Kielisch
- first_name: Jia-Xuan
  full_name: Chen, Jia-Xuan
  last_name: Chen
- first_name: Susanne
  full_name: Nguyen, Susanne
  last_name: Nguyen
- first_name: Thierry
  full_name: Schmidlin, Thierry
  last_name: Schmidlin
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: M. Felicia
  full_name: Bailicata, M. Felicia
  last_name: Bailicata
- first_name: Claudia Isabelle
  full_name: Keller Valsecchi, Claudia Isabelle
  last_name: Keller Valsecchi
citation:
  ama: Polat Haas F, Villalba Requena A, Rusina P, et al. The splicing paralogues
    SNRPB and SNRPN control differential metabolic states. <i>bioRxiv</i>. doi:<a
    href="https://doi.org/10.64898/2026.02.11.705284">10.64898/2026.02.11.705284</a>
  apa: Polat Haas, F., Villalba Requena, A., Rusina, P., Gopalan, A., Fritz, H., Akhmetkaliyev,
    A., … Keller Valsecchi, C. I. (n.d.). The splicing paralogues SNRPB and SNRPN
    control differential metabolic states. <i>bioRxiv</i>. <a href="https://doi.org/10.64898/2026.02.11.705284">https://doi.org/10.64898/2026.02.11.705284</a>
  chicago: Polat Haas, Feyza, Ana Villalba Requena, Polina Rusina, Anusha Gopalan,
    Hector Fritz, Azamat Akhmetkaliyev, Frank Ruehle, et al. “The Splicing Paralogues
    SNRPB and SNRPN Control Differential Metabolic States.” <i>BioRxiv</i>, n.d. <a
    href="https://doi.org/10.64898/2026.02.11.705284">https://doi.org/10.64898/2026.02.11.705284</a>.
  ieee: F. Polat Haas <i>et al.</i>, “The splicing paralogues SNRPB and SNRPN control
    differential metabolic states.,” <i>bioRxiv</i>. .
  ista: Polat Haas F, Villalba Requena A, Rusina P, Gopalan A, Fritz H, Akhmetkaliyev
    A, Ruehle F, Einsiedel A, Szczepinska A, Kielisch F, Chen J-X, Nguyen S, Schmidlin
    T, Hippenmeyer S, Bailicata MF, Keller Valsecchi CI. The splicing paralogues SNRPB
    and SNRPN control differential metabolic states. bioRxiv, <a href="https://doi.org/10.64898/2026.02.11.705284">10.64898/2026.02.11.705284</a>.
  mla: Polat Haas, Feyza, et al. “The Splicing Paralogues SNRPB and SNRPN Control
    Differential Metabolic States.” <i>BioRxiv</i>, doi:<a href="https://doi.org/10.64898/2026.02.11.705284">10.64898/2026.02.11.705284</a>.
  short: F. Polat Haas, A. Villalba Requena, P. Rusina, A. Gopalan, H. Fritz, A. Akhmetkaliyev,
    F. Ruehle, A. Einsiedel, A. Szczepinska, F. Kielisch, J.-X. Chen, S. Nguyen, T.
    Schmidlin, S. Hippenmeyer, M.F. Bailicata, C.I. Keller Valsecchi, BioRxiv (n.d.).
date_created: 2026-02-17T11:35:59Z
date_published: 2026-02-11T00:00:00Z
date_updated: 2026-02-23T11:03:33Z
day: '11'
department:
- _id: SiHi
doi: 10.64898/2026.02.11.705284
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.64898/2026.02.11.705284
month: '02'
oa: 1
oa_version: Preprint
publication: bioRxiv
publication_status: submitted
status: public
title: The splicing paralogues SNRPB and SNRPN control differential metabolic states.
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21291'
abstract:
- lang: eng
  text: The complexity and specificity of movement in vertebrates is driven by a rich
    diversity of spinal motor and interneuron cell types. During development, eleven
    spinal cord progenitor domains generate an equivalent number of cardinal neuron
    types. How progenitor domains, individual progenitors, and post-mitotic diversity
    relate is still unknown. We performed high-resolution, single-progenitor cell
    lineage tracing in the embryonic mouse spinal cord using mosaic analysis with
    double markers (MADM). Our quantitative study of lineage progression revealed
    that spinal cord progenitors undergo highly variable numbers of proliferative,
    neurogenic, and gliogenic cell divisions. The nascent clonally-related neurons
    migrate radially over large distances, span the dorsoventral axis, and even cross
    the midline, demonstrating striking bilaterality. Molecular and morphometric analysis
    indicate high levels of progenitor multipotency, with an individual progenitor
    capable of producing several molecularly and morphologically distinct neuron types,
    as well as astrocytes. These findings redefine spinal cord development as a process
    in which lineage variability — rather than rigid progenitor identity — drives
    the generation of cellular diversity.
acknowledged_ssus:
- _id: PreCl
- _id: Bio
acknowledgement: "We would like to thank Elizabeth Marin, Anna Kicheva, Igor Adameyko,
  and James Briscoe as\r\nwell as members of the Sweeney and Hippemeyer labs and SFB
  consortium for comments on\r\nthe manuscript. We are also grateful for the technical
  support of the Preclinical and Imaging and\r\nOptics Facilities support teams (ISTA).
  In addition, we thank our funding sources for providing\r\nthe resources to do these
  experiments: Horizon Europe ERC Starting Grant Number 101041551\r\n(M.S.; L.B.S.);
  Special Research Program (SFB) of the Austrian Science Fund (FWF)\r\nNeuroStem Modulation
  Project numbers F7814-B (S.A.G.; M.S.; G.S.; and L.B.S.) and F7805\r\n(G.C. and
  S.H.). S.A.G is supported by a Boehringer Ingelheim Fonds PhD Fellowship, F.D.S.N.\r\nby
  an Institute of Science and Technology Austria (ISTA) GROW fellowship, and G.C.
  by an\r\nISTA Plus postdoctoral fellowship from the European Commission. S.H./L.B.S.
  and G.C. were\r\nadditionally supported by institutional funds from the ISTA and
  the University of Exeter,\r\nrespectively. "
article_processing_charge: No
author:
- first_name: Sophie A
  full_name: Gobeil, Sophie A
  id: 2f3e9efb-eb24-11ec-86b2-88efb11d59fa
  last_name: Gobeil
- first_name: Francisco
  full_name: Da Silveira Neto, Francisco
  id: 8cfb7412-10a7-11f1-add1-82b44e6418f2
  last_name: Da Silveira Neto
- first_name: Giulia
  full_name: Silvestrelli, Giulia
  id: 12632ae8-799e-11ef-94a2-e5a3b5ef49e9
  last_name: Silvestrelli
- first_name: Matthijs Geert
  full_name: Smits, Matthijs Geert
  id: 7a231d52-e216-11ee-a0bb-8acd55f8f1f0
  last_name: Smits
- first_name: Carmen
  full_name: Streicher, Carmen
  id: 36BCB99C-F248-11E8-B48F-1D18A9856A87
  last_name: Streicher
- first_name: Giselle T
  full_name: Cheung, Giselle T
  id: 471195F6-F248-11E8-B48F-1D18A9856A87
  last_name: Cheung
  orcid: 0000-0001-8457-2572
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: Lora Beatrice Jaeger
  full_name: Sweeney, Lora Beatrice Jaeger
  id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
  last_name: Sweeney
  orcid: 0000-0001-9242-5601
citation:
  ama: Gobeil SA, Da Silveira Neto F, Silvestrelli G, et al. Lineage origin of spinal
    cord cell type diversity. <i>bioRxiv</i>. doi:<a href="https://doi.org/10.64898/2026.02.12.705305">10.64898/2026.02.12.705305</a>
  apa: Gobeil, S. A., Da Silveira Neto, F., Silvestrelli, G., Smits, M. G., Streicher,
    C., Cheung, G. T., … Sweeney, L. B. (n.d.). Lineage origin of spinal cord cell
    type diversity. <i>bioRxiv</i>. <a href="https://doi.org/10.64898/2026.02.12.705305">https://doi.org/10.64898/2026.02.12.705305</a>
  chicago: Gobeil, Sophie A, Francisco Da Silveira Neto, Giulia Silvestrelli, Matthijs
    Geert Smits, Carmen Streicher, Giselle T Cheung, Simon Hippenmeyer, and Lora B.
    Sweeney. “Lineage Origin of Spinal Cord Cell Type Diversity.” <i>BioRxiv</i>,
    n.d. <a href="https://doi.org/10.64898/2026.02.12.705305">https://doi.org/10.64898/2026.02.12.705305</a>.
  ieee: S. A. Gobeil <i>et al.</i>, “Lineage origin of spinal cord cell type diversity,”
    <i>bioRxiv</i>. .
  ista: Gobeil SA, Da Silveira Neto F, Silvestrelli G, Smits MG, Streicher C, Cheung
    GT, Hippenmeyer S, Sweeney LB. Lineage origin of spinal cord cell type diversity.
    bioRxiv, <a href="https://doi.org/10.64898/2026.02.12.705305">10.64898/2026.02.12.705305</a>.
  mla: Gobeil, Sophie A., et al. “Lineage Origin of Spinal Cord Cell Type Diversity.”
    <i>BioRxiv</i>, doi:<a href="https://doi.org/10.64898/2026.02.12.705305">10.64898/2026.02.12.705305</a>.
  short: S.A. Gobeil, F. Da Silveira Neto, G. Silvestrelli, M.G. Smits, C. Streicher,
    G.T. Cheung, S. Hippenmeyer, L.B. Sweeney, BioRxiv (n.d.).
corr_author: '1'
date_created: 2026-02-17T11:36:20Z
date_published: 2026-02-16T00:00:00Z
date_updated: 2026-04-14T08:16:55Z
day: '16'
ddc:
- '570'
department:
- _id: SiHi
- _id: LoSw
doi: 10.64898/2026.02.12.705305
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.64898/2026.02.12.705305
month: '02'
oa: 1
oa_version: Preprint
project:
- _id: ebb66355-77a9-11ec-83b8-b8ac210a4dae
  grant_number: '101041551'
  name: Development and Evolution of Tetrapod Motor Circuits
- _id: 8da85f50-16d5-11f0-9cad-eab8b0ff6c9e
  grant_number: F7814
  name: 'Stem Cell Modulation in Neural Development and Regeneration/ P14-Swim-to-limb
    transition: cell type to connection diversity'
- _id: 059F6AB4-7A3F-11EA-A408-12923DDC885E
  grant_number: F7805
  name: Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular
    Mechanisms of Neural Stem Cell Lineage Progression
publication: bioRxiv
publication_status: submitted
status: public
title: Lineage origin of spinal cord cell type diversity
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21311'
abstract:
- lang: eng
  text: 'Air pollution is a critical public health issue worldwide, South America
    faces unique challenges due to rapid urban growth, industrial expansion, and recurrent
    biomass burning. Existing studies have largely focused on regional or national
    scales, overlooking detailed spatio-temporal dynamics in cities. This study provides
    a comprehensive assessment of air pollution spatio-temporal trends from 2013 to
    2023 in six major South American cities: Bogotá, Buenos Aires, Montevideo, Quito,
    Santiago de Chile, and São Paulo. We evaluated four key pollutants, NO2, O3, PM10,
    and PM2.5, using in situ monitoring networks complemented with reanalysis (boundary
    layer and pollution dynamics), and fire detections datasets (biomass burning).
    A key innovation is the use of a Lagrangian Tracker, which identifies persistent
    hotspots and transport pathways of pollutants, offering new insights into transboundary
    pollution. Results show that nearly all cities experienced reductions in particulate
    matter concentrations, while three of the six cities exhibited rising O3 levels,
    reflecting complex interactions between emissions, meteorology, and atmospheric
    chemistry. Santiago de Chile recorded the highest levels of NO2 and PM, strongly
    influenced by topography and biomass burning in JJA. Bogotá and Quito were notably
    impacted by regional fire emissions, whereas coastal cities such as Buenos Aires
    and Montevideo benefited from greater pollutant dispersion but still exceeded
    the World Health Organization guidelines. By integrating ground-based, satellite,
    and reanalysis data with advanced trajectory modeling, this research provides
    detailed spatio-temporal evaluations of air pollution in South America and highlights
    the urgent need for coordinated regional strategies to reduce health and economic
    burdens.'
acknowledgement: 'The author would like to thank Fundación Universitaria Los Libertadores
  (Project ID: ING-40-25) for supporting her in this work. And EALB, would like to
  thank Universidad Sergio Arboleda (Project ID: IN.BG.086.24.015) for supporting
  her in this work. Open access funding provided by Institute of Science and Technology
  (IST Austria). The first author was funded by the Fundacion Universitaria Los Libertadores
  (Project ID: ING-40-25). This project has received funding from the European Union’s
  Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie
  grant agreement No 101034413289 awarded to AC. EALB was supported by Universidad
  Sergio Arboleda (Project ID: IN.BG.086.24.015).'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Yuri
  full_name: González, Yuri
  last_name: González
- first_name: Nicolás
  full_name: Malagón, Nicolás
  last_name: Malagón
- first_name: Kevin
  full_name: Benavides, Kevin
  last_name: Benavides
- first_name: Luis Carlos
  full_name: Belalcázar, Luis Carlos
  last_name: Belalcázar
- first_name: Ellie Anne
  full_name: Lopez-Barrera, Ellie Anne
  last_name: Lopez-Barrera
- first_name: Alejandro
  full_name: Casallas Garcia, Alejandro
  id: 92081129-2d75-11ef-a48d-b04dd7a2385a
  last_name: Casallas Garcia
  orcid: 0000-0002-1988-5035
citation:
  ama: González Y, Malagón N, Benavides K, Belalcázar LC, Lopez-Barrera EA, Casallas
    Garcia A. Spatio-temporal trends of air pollution in six South American cities.
    <i>Earth Systems and Environment</i>. 2026. doi:<a href="https://doi.org/10.1007/s41748-026-01068-9">10.1007/s41748-026-01068-9</a>
  apa: González, Y., Malagón, N., Benavides, K., Belalcázar, L. C., Lopez-Barrera,
    E. A., &#38; Casallas Garcia, A. (2026). Spatio-temporal trends of air pollution
    in six South American cities. <i>Earth Systems and Environment</i>. Springer Nature.
    <a href="https://doi.org/10.1007/s41748-026-01068-9">https://doi.org/10.1007/s41748-026-01068-9</a>
  chicago: González, Yuri, Nicolás Malagón, Kevin Benavides, Luis Carlos Belalcázar,
    Ellie Anne Lopez-Barrera, and Alejandro Casallas Garcia. “Spatio-Temporal Trends
    of Air Pollution in Six South American Cities.” <i>Earth Systems and Environment</i>.
    Springer Nature, 2026. <a href="https://doi.org/10.1007/s41748-026-01068-9">https://doi.org/10.1007/s41748-026-01068-9</a>.
  ieee: Y. González, N. Malagón, K. Benavides, L. C. Belalcázar, E. A. Lopez-Barrera,
    and A. Casallas Garcia, “Spatio-temporal trends of air pollution in six South
    American cities,” <i>Earth Systems and Environment</i>. Springer Nature, 2026.
  ista: González Y, Malagón N, Benavides K, Belalcázar LC, Lopez-Barrera EA, Casallas
    Garcia A. 2026. Spatio-temporal trends of air pollution in six South American
    cities. Earth Systems and Environment.
  mla: González, Yuri, et al. “Spatio-Temporal Trends of Air Pollution in Six South
    American Cities.” <i>Earth Systems and Environment</i>, Springer Nature, 2026,
    doi:<a href="https://doi.org/10.1007/s41748-026-01068-9">10.1007/s41748-026-01068-9</a>.
  short: Y. González, N. Malagón, K. Benavides, L.C. Belalcázar, E.A. Lopez-Barrera,
    A. Casallas Garcia, Earth Systems and Environment (2026).
corr_author: '1'
date_created: 2026-02-18T07:11:14Z
date_published: 2026-02-17T00:00:00Z
date_updated: 2026-02-23T11:57:21Z
day: '17'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1007/s41748-026-01068-9
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1007/s41748-026-01068-9
month: '02'
oa: 1
oa_version: Published Version
publication: Earth Systems and Environment
publication_identifier:
  eissn:
  - 2509-9434
  issn:
  - 2509-9426
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Spatio-temporal trends of air pollution in six South American cities
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
