---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22941'
abstract:
- lang: eng
text: Argonaute proteins mediate RNA interference in eukaryotes and nucleic‐acid
defence in prokaryotes. Although these systems operate in distinct biological
contexts and produce diverse downstream outcomes, they share a conserved structural
architecture and mechanism of guide‐dependent target recognition. Here, we argue
that Argonautes function as programmable surveillance platforms that kinetically
sample nucleic acids, engage targets through sequential pairing and conformational
checkpoints, and couple recognition to functional outputs through regulated structural
transitions. Rather than representing distinct recognition mechanisms, the diverse
targeting behaviours observed across Argonaute families reflect different implementations
of this shared framework, in which guide biogenesis, target accessibility, pairing
requirements and effector coupling are weighted differently according to biological
context. Viewing Argonautes through this common operational logic reconciles apparent
differences in specificity, mismatch tolerance and target selection across systems,
while providing a unified conceptual framework for understanding their evolution
and guiding the engineering of programmable nucleic‐acid recognition technologies.
acknowledgement: I would like to thank K. Kiernan and F. Alcon for insightful comments
and feedback. We acknowledge support from ISTA and from the Austrian Science Fund
(FWF) (10.55776/PAT1617625). The author used Claude (Anthropic) to assist with improving
the clarity and readability of portions of the manuscript. All scientific content,
interpretation and conclusions were conceived, verified and approved by the author,
who takes full responsibility for the final manuscript. Open Access funding provided
by Institute of Science and Technology Austria.
article_number: 1873-3468.70450
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Jack Peter Kelly
full_name: Bravo, Jack Peter Kelly
id: 96aecfa5-8931-11ee-af30-aa6a5d6eee0e
last_name: Bravo
orcid: 0000-0003-0456-0753
citation:
ama: Bravo JPK. ‘Guide and Prejudice’ - How Argonautes recognize targets across
domains of life. FEBS Letters. 2026. doi:10.1002/1873-3468.70450
apa: Bravo, J. P. K. (2026). ‘Guide and Prejudice’ - How Argonautes recognize targets
across domains of life. FEBS Letters. Wiley. https://doi.org/10.1002/1873-3468.70450
chicago: Bravo, Jack Peter Kelly. “‘Guide and Prejudice’ - How Argonautes Recognize
Targets across Domains of Life.” FEBS Letters. Wiley, 2026. https://doi.org/10.1002/1873-3468.70450.
ieee: J. P. K. Bravo, “‘Guide and Prejudice’ - How Argonautes recognize targets
across domains of life,” FEBS Letters. Wiley, 2026.
ista: Bravo JPK. 2026. ‘Guide and Prejudice’ - How Argonautes recognize targets
across domains of life. FEBS Letters., 1873–3468.70450.
mla: Bravo, Jack Peter Kelly. “‘Guide and Prejudice’ - How Argonautes Recognize
Targets across Domains of Life.” FEBS Letters, 1873–3468.70450, Wiley,
2026, doi:10.1002/1873-3468.70450.
short: J.P.K. Bravo, FEBS Letters (2026).
corr_author: '1'
das_tickbox: '0'
date_created: 2026-09-17T09:31:02Z
date_published: 2026-09-08T00:00:00Z
date_updated: 2026-09-17T11:48:51Z
day: '08'
ddc:
- '570'
department:
- _id: JaBr
doi: 10.1002/1873-3468.70450
external_id:
pmid:
- '42711859'
fulldoi: https://doi.org/10.1002/1873-3468.70450
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1002/1873-3468.70450
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 9f295cab-ad08-11f1-bc83-9e197d0f6d50
grant_number: PAT1617625
name: 'Search & Destroy: Mechanisms of anti-plasmid immunity'
publication: FEBS Letters
publication_identifier:
eissn:
- 1873-3468
issn:
- 0014-5793
publication_status: epub_ahead
publisher: Wiley
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: ‘Guide and Prejudice’ - How Argonautes recognize targets across domains of
life
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21501'
abstract:
- lang: eng
text: "Kinetically constrained models were originally introduced to capture slow
relaxation in glassy systems, where dynamics are hindered by local constraints
instead of energy barriers. Their quantum counterparts have recently drawn attention
for exhibiting highly degenerate eigenstates at zero energy—known as zero modes—stemming
from chiral symmetry. Yet, the structure and implications of these zero modes
remain poorly understood. In this work, we focus on the properties of the zero
mode subspace in quantum kinetically constrained models with a U(1) particle-conservation
symmetry. We use the U(1) East, which lacks inversion symmetry, and the inversion-symmetric
U(1) East-West models to illustrate our two main results. First, we observe that
the simultaneous presence of constraints and chiral symmetry generally leads to
a parametric increase in the number of zero modes due to the fragmentation of
the many-body\r\nHilbert space into disconnected sectors. Second, we generalize
the concept of compact localized states from single-particle physics and introduce
the notion of collective bound states, a special kind of nonergodic eigenstates
that are robust to enlarging the system size. We formulate sufficient criteria
for their existence, arguing that the degenerate zero mode subspace plays a central
role, and demonstrate bound states in both example models and in a two-dimensional
model, the U(1) North-East, and in the pairflip model, a system without particle
conservation. Our results motivate a systematic study of bound states and their
relation to ergodicity breaking, transport, and other properties of quantum kinetically
constrained\r\nmodels. "
acknowledgement: The authors acknowledge useful discussions with Berislav Buca. This
work was supported by the European Research Council (ERC) under the European Union’s
Horizon 2020 research and innovation program (Grant Agreement No. 850899). M.L.
acknowledges support by the Deutsche Forschungsgemeinschaft (DFG, German Research
Foundation) under Germany’s Excellence Strategy—EXC-2111—390814868. This research
was supported in part by grant NSF PHY-2309135 to the Kavli Institute for Theoretical
Physics (KITP).
article_number: '010352'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Eulalia
full_name: Nicolau Jimenez, Eulalia
id: 04b4791c-8fd7-11ee-a7df-be2fdc569c48
last_name: Nicolau Jimenez
- first_name: Marko
full_name: Ljubotina, Marko
id: F75EE9BE-5C90-11EA-905D-16643DDC885E
last_name: Ljubotina
orcid: 0000-0003-0038-7068
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
citation:
ama: Nicolau Jimenez E, Ljubotina M, Serbyn M. Fragmentation, zero modes, and collective
bound states in constrained models. PRX Quantum. 2026;7. doi:10.1103/sl79-1xgb
apa: Nicolau Jimenez, E., Ljubotina, M., & Serbyn, M. (2026). Fragmentation,
zero modes, and collective bound states in constrained models. PRX Quantum.
American Physical Society. https://doi.org/10.1103/sl79-1xgb
chicago: Nicolau Jimenez, Eloi, Marko Ljubotina, and Maksym Serbyn. “Fragmentation,
Zero Modes, and Collective Bound States in Constrained Models.” PRX Quantum.
American Physical Society, 2026. https://doi.org/10.1103/sl79-1xgb.
ieee: E. Nicolau Jimenez, M. Ljubotina, and M. Serbyn, “Fragmentation, zero modes,
and collective bound states in constrained models,” PRX Quantum, vol. 7.
American Physical Society, 2026.
ista: Nicolau Jimenez E, Ljubotina M, Serbyn M. 2026. Fragmentation, zero modes,
and collective bound states in constrained models. PRX Quantum. 7, 010352.
mla: Nicolau Jimenez, Eloi, et al. “Fragmentation, Zero Modes, and Collective Bound
States in Constrained Models.” PRX Quantum, vol. 7, 010352, American Physical
Society, 2026, doi:10.1103/sl79-1xgb.
short: E. Nicolau Jimenez, M. Ljubotina, M. Serbyn, PRX Quantum 7 (2026).
corr_author: '1'
date_created: 2026-03-28T14:57:56Z
date_published: 2026-03-13T00:00:00Z
date_updated: 2026-09-17T11:50:06Z
day: '13'
ddc:
- '530'
department:
- _id: MaSe
doi: 10.1103/sl79-1xgb
ec_funded: 1
external_id:
arxiv:
- '2504.17627'
file:
- access_level: open_access
checksum: d155ffa9e1a8275702149165f4bf963c
content_type: application/pdf
creator: dernst
date_created: 2026-03-30T06:08:07Z
date_updated: 2026-03-30T06:08:07Z
file_id: '21505'
file_name: 2026_PRXQuantum_Nicolau.pdf
file_size: 1848724
relation: main_file
success: 1
file_date_updated: 2026-03-30T06:08:07Z
fulldoi: https://doi.org/10.1103/sl79-1xgb
has_accepted_license: '1'
intvolume: ' 7'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
project:
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '850899'
name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication: PRX Quantum
publication_identifier:
eissn:
- 2691-3399
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fragmentation, zero modes, and collective bound states in constrained models
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2026'
...
---
OA_place: publisher
OA_type: gold
_id: '22245'
abstract:
- lang: eng
text: "A single-commodity congestion approximator for a graph is a compact data
structure that approximately predicts the edge congestion required to route any
set of single-commodity flow demands in a network. A hierarchical congestion approximator
(HCA) consists of a laminar family of cuts in the graph and has numerous applications
in approximating cut and flow problems in graphs, designing efficient routing
schemes, and managing distributed networks.\r\nThere is a tradeoff between the
running time for computing an HCA and its approximation quality. The best polynomial-time
construction in an n-node graph gives an HCA with approximation quality O(log1.5n
loglogn). Among near-linear time algorithms, the best previous result achieves
approximation quality O(log4 n). We improve upon the latter result by giving the
first near-linear time algorithm for computing an HCA with approximation quality
O(log2 n loglogn). Additionally, our algorithm can be implemented in the parallel
setting with polylogarithmic span and near-linear work, achieving the same approximation
quality. This improves upon the best previous such algorithm, which has an O(log9n)
approximation quality. We also present a lower bound of Ω(logn) for the approximation
guarantee of hierarchical congestion approximators.\r\nCrucial for achieving a
near-linear running time is a new partitioning routine that, unlike previous such
routines, manages to avoid recursing on large subgraphs. To achieve the improved
approximation quality, we introduce the new concept of border routability of a
cut and provide an improved sparsest cut oracle for general vertex weights."
acknowledgement: "We thank Evangelos Kosinas for helpful discussions on this topic.\r\nFunded
by the European Union. Views and opinions expressed\r\nare however those of the
author(s) only and do not necessarily\r\nreflect those of the European Union or
the European Research\r\nCouncil Executive Agency. Neither the European Union nor
the\r\ngranting authority can be held responsible for them.\r\nThis project has
received funding from the European Research\r\nCouncil (ERC) under the European
Union’s Horizon 2020 research\r\nand innovation programme (MoDynStruct, No. 101019564)\r\nand
the Austrian Science Fund (FWF) grant DOI 10.55776/I5982. For\r\nopen access purposes,
the author has applied a CC BY public copyright license to any author-accepted manuscript
version arising\r\nfrom this submission.\r\nThis project has received funding from
the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – 498605858."
article_processing_charge: Yes
arxiv: 1
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Robin
full_name: Münk, Robin
last_name: Münk
- first_name: Harald
full_name: Räcke, Harald
last_name: Räcke
citation:
ama: 'Henzinger M, Münk R, Räcke H. An improved quality hierarchical congestion
approximator in near-linear time. In: 58th Annual ACM Symposium on Theory of
Computing. ACM; 2026:1417-1428. doi:10.1145/3798129.3800851'
apa: 'Henzinger, M., Münk, R., & Räcke, H. (2026). An improved quality hierarchical
congestion approximator in near-linear time. In 58th Annual ACM Symposium on
Theory of Computing (pp. 1417–1428). Salt Lake City, UT, United States: ACM.
https://doi.org/10.1145/3798129.3800851'
chicago: Henzinger, Monika, Robin Münk, and Harald Räcke. “An Improved Quality Hierarchical
Congestion Approximator in Near-Linear Time.” In 58th Annual ACM Symposium
on Theory of Computing, 1417–28. ACM, 2026. https://doi.org/10.1145/3798129.3800851.
ieee: M. Henzinger, R. Münk, and H. Räcke, “An improved quality hierarchical congestion
approximator in near-linear time,” in 58th Annual ACM Symposium on Theory of
Computing, Salt Lake City, UT, United States, 2026, pp. 1417–1428.
ista: 'Henzinger M, Münk R, Räcke H. 2026. An improved quality hierarchical congestion
approximator in near-linear time. 58th Annual ACM Symposium on Theory of Computing.
STOC: Symposium on the Theory of Computing, 1417–1428.'
mla: Henzinger, Monika, et al. “An Improved Quality Hierarchical Congestion Approximator
in Near-Linear Time.” 58th Annual ACM Symposium on Theory of Computing,
ACM, 2026, pp. 1417–28, doi:10.1145/3798129.3800851.
short: M. Henzinger, R. Münk, H. Räcke, in:, 58th Annual ACM Symposium on Theory
of Computing, ACM, 2026, pp. 1417–1428.
conference:
end_date: 2026-06-26
location: Salt Lake City, UT, United States
name: 'STOC: Symposium on the Theory of Computing'
start_date: 2026-06-22
corr_author: '1'
das_tickbox: '0'
date_created: 2026-07-05T22:01:36Z
date_published: 2026-06-09T00:00:00Z
date_updated: 2026-09-17T12:39:36Z
day: '09'
ddc:
- '000'
department:
- _id: MoHe
doi: 10.1145/3798129.3800851
ec_funded: 1
external_id:
arxiv:
- '2511.03716'
file:
- access_level: open_access
checksum: 2bef46be8da6d19a641697bb0d8ade65
content_type: application/pdf
creator: dernst
date_created: 2026-07-06T06:57:16Z
date_updated: 2026-07-06T06:57:16Z
file_id: '22250'
file_name: 2026_STOC_HenzingerMo.pdf
file_size: 919005
relation: main_file
success: 1
file_date_updated: 2026-07-06T06:57:16Z
fulldoi: https://doi.org/10.1145/3798129.3800851
has_accepted_license: '1'
keyword:
- Congestion Approximators
- Hierarchical Graph Decompositions
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 1417-1428
project:
- _id: bd9ca328-d553-11ed-ba76-dc4f890cfe62
call_identifier: H2020
grant_number: '101019564'
name: The design and evaluation of modern fully dynamic data structures
- _id: bda196b2-d553-11ed-ba76-8e8ee6c21103
grant_number: I05982
name: Static and Dynamic Hierarchical Graph Decompositions
publication: 58th Annual ACM Symposium on Theory of Computing
publication_identifier:
isbn:
- '9798400725364'
issn:
- 0737-8017
publication_status: published
publisher: ACM
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: An improved quality hierarchical congestion approximator in near-linear time
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: gold
_id: '21921'
abstract:
- lang: eng
text: "A variety of problems in geometry processing boil down to finding the most\r\nparallel
field relative to a connection. Instances of this prototypical problem\r\nshow
up in computing direction fields and stripe patterns, quadrilateral\r\nmeshing,
and visualization of fluid flows. When the class of allowed fields\r\nincludes
those with topological defects, a relaxation is required to make\r\nthe problem
well-posed. We observe that these problems can be viewed\r\nas synchronization
problems, which admit a natural semidefinite relaxation.\r\nWe propose a unified
method of solving all these problems via the efficient\r\nBurer-Monteiro factorization
method. Geometrically, this amounts to lifting the field values to a higher-dimensional
manifold, naturally resolving\r\nthe singular nature of defects. Practically,
we show that our convex relaxation method achieves better and more reliable optima
than previous work\r\nemploying alternative relaxations"
acknowledgement: "The authors thank Steven J. Gortler and Nicolas Boumal for interesting
discussions.\r\nDavid Palmer acknowledges the generous support of the NSF\r\nMSPRF
under award #2303403 during his time at Harvard University.\r\nNatalia Pacheco-Tallaj
was supported by the NSF DGE-2141064.\r\nMattéo Couplet was supported by Wallonie-Bruxelles
International"
article_processing_charge: No
author:
- first_name: Natalia
full_name: Pacheco-Tallaj, Natalia
last_name: Pacheco-Tallaj
- first_name: Matteo
full_name: Couplet, Matteo
last_name: Couplet
- first_name: Edward
full_name: Chien, Edward
last_name: Chien
- first_name: David
full_name: Palmer, David
id: 6574708f-2fd3-11f0-89e2-ae42ebc712a4
last_name: Palmer
orcid: 0000-0002-1931-5673
citation:
ama: 'Pacheco-Tallaj N, Couplet M, Chien E, Palmer D. Synchronizing fields with
singularities. In: SIGGRAPH Conference Papers. ACM; 2026. doi:10.1145/3799902.3811225'
apa: 'Pacheco-Tallaj, N., Couplet, M., Chien, E., & Palmer, D. (2026). Synchronizing
fields with singularities. In SIGGRAPH Conference Papers. Los Angeles,
CA, United States: ACM. https://doi.org/10.1145/3799902.3811225'
chicago: Pacheco-Tallaj, Natalia, Matteo Couplet, Edward Chien, and David Palmer.
“Synchronizing Fields with Singularities.” In SIGGRAPH Conference Papers.
ACM, 2026. https://doi.org/10.1145/3799902.3811225.
ieee: N. Pacheco-Tallaj, M. Couplet, E. Chien, and D. Palmer, “Synchronizing fields
with singularities,” in SIGGRAPH Conference Papers, Los Angeles, CA, United
States, 2026.
ista: 'Pacheco-Tallaj N, Couplet M, Chien E, Palmer D. 2026. Synchronizing fields
with singularities. SIGGRAPH Conference Papers. SIGGRAPH: International Conference
and Exhibition on Computer Graphics and Interactive Techniques.'
mla: Pacheco-Tallaj, Natalia, et al. “Synchronizing Fields with Singularities.”
SIGGRAPH Conference Papers, ACM, 2026, doi:10.1145/3799902.3811225.
short: N. Pacheco-Tallaj, M. Couplet, E. Chien, D. Palmer, in:, SIGGRAPH Conference
Papers, ACM, 2026.
conference:
end_date: 2026-07-23
location: Los Angeles, CA, United States
name: 'SIGGRAPH: International Conference and Exhibition on Computer Graphics and
Interactive Techniques'
start_date: 2026-07-19
corr_author: '1'
das_tickbox: '0'
date_created: 2026-05-29T12:53:59Z
date_published: 2026-06-01T00:00:00Z
date_updated: 2026-09-17T12:37:42Z
day: '01'
ddc:
- '000'
department:
- _id: ChWo
doi: 10.1145/3799902.3811225
file:
- access_level: open_access
checksum: 501e37133361dd0de7f817644e8915da
content_type: application/pdf
creator: dernst
date_created: 2026-09-17T12:36:14Z
date_updated: 2026-09-17T12:36:14Z
file_id: '22962'
file_name: 2026_ACMSiggraph_PachecoTallaj.pdf
file_size: 39559100
relation: main_file
success: 1
file_date_updated: 2026-09-17T12:36:14Z
fulldoi: https://doi.org/10.1145/3799902.3811225
has_accepted_license: '1'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
publication: SIGGRAPH Conference Papers
publication_identifier:
eisbn:
- '9798400725548'
publication_status: published
publisher: ACM
quality_controlled: '1'
researchdata_availability: no
status: public
supplementarymaterial: no
title: Synchronizing fields with singularities
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
_id: '22808'
abstract:
- lang: eng
text: "As automated decision-makers have become ubiquitous in many domains of life,\r\ntheir
decisions have become increasingly consequential. Recent years have shown\r\nthat
such systems can exhibit discriminatory behaviour against individuals and\r\nsocial
groups alike, thereby amplifying existing biases and entrenching\r\nsocio-economic
disparities over time. Algorithmic fairness addresses this\r\nproblem by developing
methods to quantify and mitigate unfair behaviour.\r\nHowever, much of the existing
literature studies fairness in a static\r\npre-deployment setting and, therefore,
neglects that automated decision-makers are\r\noften deployed in dynamic environments,
where their behaviour and the\r\npopulations they affect may change over time.\r\n\r\nThis
thesis addresses this gap through the lens of runtime verification.\r\nInstead
of treating fairness as a property of a classifier together with a fixed\r\ninput
distribution, it reframes fairness as a property of the interaction trace\r\nbetween
the decision-maker and its deployment environment. To evaluate such\r\nsequential
fairness properties, the thesis develops runtime monitors that\r\nobserve the
evolving interaction between the system and the environment and\r\nissue verdicts
after each new observation. Because, these monitors are designed to detect\r\nunfair
behaviour during deployment, they complement fair training,\r\nauditing, verification,
and enforcement by providing an additional layer of mathematically rigorous fairness
assurance.\r\n\r\nIn summary, the thesis develops quantitative, trace-based analogues
of\r\nclassical group and individual fairness measures and constructs monitors
for\r\nthem. This includes monitors for long-run group fairness over Markovian
traces,\r\nfor the time-varying welfare of a changing population in a dynamical
system, and\r\nfor the individual fairness of an arbitrary system generating a
trace of inputs\r\nand outputs. To achieve this, the monitors combine ideas from
runtime\r\nverification, sequential statistics, and nearest-neighbour search.
In the\r\ngroup-fairness settings, monitoring is primarily a sequential statistical\r\nestimation
problem: the monitor must construct statistically sound interval\r\nestimates
of fairness values from dependent and partially observed interactions.\r\nIn the
individual-fairness setting, the main challenge is computational\r\nefficiency:
the monitor must detect individual fairness violations by efficiently comparing
the\r\ncurrent decision with all previously observed decisions.\r\n"
acknowledgement: "This work was supported in part by the ERC-2020-AdG 101020093 (VAMOS).\r\n"
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Konstantin
full_name: Kueffner, Konstantin
id: 8121a2d0-dc85-11ea-9058-af578f3b4515
last_name: Kueffner
orcid: 0000-0001-8974-2542
citation:
ama: Kueffner K. Monitoring algorithmic fairness in sequential decision making.
2026. doi:10.15479/AT-ISTA-22808
apa: Kueffner, K. (2026). Monitoring algorithmic fairness in sequential decision
making. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-22808
chicago: Kueffner, Konstantin. “Monitoring Algorithmic Fairness in Sequential Decision
Making.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-22808.
ieee: K. Kueffner, “Monitoring algorithmic fairness in sequential decision making,”
Institute of Science and Technology Austria, 2026.
ista: Kueffner K. 2026. Monitoring algorithmic fairness in sequential decision making.
Institute of Science and Technology Austria.
mla: Kueffner, Konstantin. Monitoring Algorithmic Fairness in Sequential Decision
Making. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-22808.
short: K. Kueffner, Monitoring Algorithmic Fairness in Sequential Decision Making,
Institute of Science and Technology Austria, 2026.
corr_author: '1'
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call_identifier: H2020
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name: Vigilant Algorithmic Monitoring of Software
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issn:
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supervisor:
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full_name: Henzinger, Thomas A
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orcid: 0000-0002-2985-7724
title: Monitoring algorithmic fairness in sequential decision making
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acknowledgement: I acknowledge funding by the Austrian Science Fund (FWF) [10.55776/PAT8537123].
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author:
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full_name: Ehrmann, Andreas
id: eaa689ed-f6e0-11ea-865d-bd98cbcf83c2
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orcid: 0000-0002-0997-5678
citation:
ama: 'Ehrmann A. Biological functionality without biochemistry: Designing nanomachines
for target behavior. 2026. doi:10.15479/AT-ISTA-22873'
apa: 'Ehrmann, A. (2026). Biological functionality without biochemistry: Designing
nanomachines for target behavior. Institute of Science and Technology Austria.
https://doi.org/10.15479/AT-ISTA-22873'
chicago: 'Ehrmann, Andreas. “Biological Functionality without Biochemistry: Designing
Nanomachines for Target Behavior.” Institute of Science and Technology Austria,
2026. https://doi.org/10.15479/AT-ISTA-22873.'
ieee: 'A. Ehrmann, “Biological functionality without biochemistry: Designing nanomachines
for target behavior,” Institute of Science and Technology Austria, 2026.'
ista: 'Ehrmann A. 2026. Biological functionality without biochemistry: Designing
nanomachines for target behavior. Institute of Science and Technology Austria.'
mla: 'Ehrmann, Andreas. Biological Functionality without Biochemistry: Designing
Nanomachines for Target Behavior. Institute of Science and Technology Austria,
2026, doi:10.15479/AT-ISTA-22873.'
short: 'A. Ehrmann, Biological Functionality without Biochemistry: Designing Nanomachines
for Target Behavior, Institute of Science and Technology Austria, 2026.'
corr_author: '1'
das_tickbox: '0'
date_created: 2026-09-09T12:18:24Z
date_published: 2026-09-04T00:00:00Z
date_updated: 2026-09-18T11:28:29Z
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description: All LaTeX files to compile my PhD Thesis.
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has_accepted_license: '1'
keyword:
- PhD Thesis
- functional nanomachines
- biological functionality
- nanotechnology
- energy delivery
- target behavior
- dynamics
- design principles
- optimization
- differentiable statistical physics
- machine learning
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '09'
oa_version: Published Version
page: '168'
project:
- _id: 90a98bb5-16d5-11f0-9cad-9675f3f8015d
grant_number: PAT 8537123
name: Functional bio-inspired nanomachines from sticky colloids
publication_identifier:
isbn:
- 978-3-99078-092-3
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
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- id: '22893'
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status: public
supervisor:
- first_name: Carl Peter
full_name: Goodrich, Carl Peter
id: EB352CD2-F68A-11E9-89C5-A432E6697425
last_name: Goodrich
orcid: 0000-0002-1307-5074
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
supplementarymaterial: not applicable
title: 'Biological functionality without biochemistry: Designing nanomachines for
target behavior'
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abstract:
- lang: eng
text: Many biological machines function through controlled conformational transitions,
yet designing synthetic nanostructures with prescribed dynamical behavior remains
a major challenge. Here, we develop a modular inverse-design framework for bistable
nanostructures whose function is controlled by an energy profile along a geometric
reaction coordinate. Inspired by proteins with rigid domains connected by flexible
hinges, we introduce a hinge-arm paradigm in which a small bistable hinge controls
the energetics of a conformational transition, while rigid arms map this transition
onto the separation between external binding sites. Specifically, we ask which
features of a target energy profile can be programmed under different design constraints.
We find that the energy barriers and the binding-site separations in the two metastable
states can be readily designed, while controlling the location of the transition
state or the full shape of the energy profile requires additional design freedom.
Using a differentiable design framework, we find that some optimized solutions
are numerically inexact but still display the functional behavior for which the
target profile was selected, emphasizing the importance of function-based evaluation
criteria. These results establish a practical hierarchy of designability for bistable
nanostructures and provide a route toward synthetic nanomachines that couple conformational
transitions to target behavior.
acknowledgement: "We thank Maitane Muñoz-Basagoiti for stimulating\r\ndiscussions.
This research was funded in part by the\r\nAustrian Science Fund (FWF) [10.55776/PAT8537123].\r\n"
article_processing_charge: No
arxiv: 1
author:
- first_name: Andreas
full_name: Ehrmann, Andreas
id: eaa689ed-f6e0-11ea-865d-bd98cbcf83c2
last_name: Ehrmann
orcid: 0000-0002-0997-5678
- first_name: Marija
full_name: Krstić, Marija
id: a8f6d1c6-3200-11ee-973b-dab948eace26
last_name: Krstić
- first_name: Sahar
full_name: Samadzadeh, Sahar
id: 0099896b-5fb8-11ef-8420-b30b14627e93
last_name: Samadzadeh
- first_name: Carl Peter
full_name: Goodrich, Carl Peter
id: EB352CD2-F68A-11E9-89C5-A432E6697425
last_name: Goodrich
orcid: 0000-0002-1307-5074
citation:
ama: Ehrmann A, Krstić M, Samadzadeh S, Goodrich CP. Designing bistable nanostructures
for target behavior. arXiv. doi:10.48550/arXiv.2606.31620
apa: Ehrmann, A., Krstić, M., Samadzadeh, S., & Goodrich, C. P. (n.d.). Designing
bistable nanostructures for target behavior. arXiv. https://doi.org/10.48550/arXiv.2606.31620
chicago: Ehrmann, Andreas, Marija Krstić, Sahar Samadzadeh, and Carl Peter Goodrich.
“Designing Bistable Nanostructures for Target Behavior.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2606.31620.
ieee: A. Ehrmann, M. Krstić, S. Samadzadeh, and C. P. Goodrich, “Designing bistable
nanostructures for target behavior,” arXiv. .
ista: Ehrmann A, Krstić M, Samadzadeh S, Goodrich CP. Designing bistable nanostructures
for target behavior. arXiv, 10.48550/arXiv.2606.31620.
mla: Ehrmann, Andreas, et al. “Designing Bistable Nanostructures for Target Behavior.”
ArXiv, doi:10.48550/arXiv.2606.31620.
short: A. Ehrmann, M. Krstić, S. Samadzadeh, C.P. Goodrich, ArXiv (n.d.).
corr_author: '1'
date_created: 2026-09-09T13:19:13Z
date_published: 2026-06-30T00:00:00Z
date_updated: 2026-09-18T11:28:28Z
day: '30'
department:
- _id: CaGo
- _id: EdHa
- _id: AnSa
doi: 10.48550/arXiv.2606.31620
external_id:
arxiv:
- '2606.31620'
fulldoi: https://doi.org/10.48550/arXiv.2606.31620
language:
- iso: eng
main_file_link:
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url: https://doi.org/10.48550/arXiv.2606.31620
month: '06'
oa: 1
oa_version: Preprint
project:
- _id: 90a98bb5-16d5-11f0-9cad-9675f3f8015d
grant_number: PAT 8537123
name: Functional bio-inspired nanomachines from sticky colloids
publication: arXiv
publication_status: draft
related_material:
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- id: '22873'
relation: dissertation_contains
status: public
status: public
title: Designing bistable nanostructures for target behavior
tmp:
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...
---
OA_place: repository
_id: '22892'
abstract:
- lang: eng
text: 'Countless biological processes are fueled by energy-rich molecules like ATP
and GTP that supply energy with extreme efficiency. However, designing similar
energy-delivery schemes from the bottom up, essential for the development of powered
nanostructures and other \emph{de novo} machinery, presents a significant challenge:
how can an energy-rich structure be stable in solution yet still deliver this
energy at precisely the right time? In this paper, we present a purely physical
mechanism that solves this challenge, facilitating energy transfer akin to ATP
hydrolysis, yet occurring between synthetic nanostructures without any biochemical
interactions. This targeted energy delivery is achieved by exploiting a differentiable
state-based model to balance the energy profiles that govern the structural transitions
in the two nanostructures, creating a coupled relaxation pathway with minimal
barriers that facilitates energy delivery. We verify the effectiveness and robustness
of this mechanism through Langevin Dynamics simulations, demonstrating that a
bath of the high-energy structures can systematically and repeatedly drive the
target structure out of equilibrium, enabling it to perform tasks. As the mechanism
operates only through explicit physical forces without any biochemistry or internal
state variables, our results present generic and far-reaching design principles,
setting the stage for the next generation of synthetic nanomachines.'
acknowledgement: "We thank Edouard Hannezo, Ella King, Maximilian Lechner, and Jérémie
Palacci for stimulating discussions, and Edouard Hannezo, Maximilian Hübl, and\r\nMaitane
Muñoz-Basagoiti for helpful comments on the manuscript. This research was funded
in part by the\r\nAustrian Science Fund (FWF) [10.55776/PAT8537123]."
article_processing_charge: No
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author:
- first_name: Andreas
full_name: Ehrmann, Andreas
id: eaa689ed-f6e0-11ea-865d-bd98cbcf83c2
last_name: Ehrmann
orcid: 0000-0002-0997-5678
- first_name: Carl Peter
full_name: Goodrich, Carl Peter
id: EB352CD2-F68A-11E9-89C5-A432E6697425
last_name: Goodrich
orcid: 0000-0002-1307-5074
citation:
ama: Ehrmann A, Goodrich CP. Controlling energy delivery with bistable nanostructures.
arXiv. doi:10.48550/arXiv.2506.14266
apa: Ehrmann, A., & Goodrich, C. P. (n.d.). Controlling energy delivery with
bistable nanostructures. arXiv. https://doi.org/10.48550/arXiv.2506.14266
chicago: Ehrmann, Andreas, and Carl Peter Goodrich. “Controlling Energy Delivery
with Bistable Nanostructures.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2506.14266.
ieee: A. Ehrmann and C. P. Goodrich, “Controlling energy delivery with bistable
nanostructures,” arXiv. .
ista: Ehrmann A, Goodrich CP. Controlling energy delivery with bistable nanostructures.
arXiv, 10.48550/arXiv.2506.14266.
mla: Ehrmann, Andreas, and Carl Peter Goodrich. “Controlling Energy Delivery with
Bistable Nanostructures.” ArXiv, doi:10.48550/arXiv.2506.14266.
short: A. Ehrmann, C.P. Goodrich, ArXiv (n.d.).
corr_author: '1'
date_created: 2026-09-09T13:16:54Z
date_published: 2026-06-07T00:00:00Z
date_updated: 2026-09-18T11:28:29Z
day: '07'
department:
- _id: CaGo
- _id: EdHa
doi: 10.48550/arXiv.2506.14266
external_id:
arxiv:
- '2506.14266'
fulldoi: https://doi.org/10.48550/arXiv.2506.14266
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- iso: eng
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month: '06'
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oa_version: Preprint
project:
- _id: 90a98bb5-16d5-11f0-9cad-9675f3f8015d
grant_number: PAT 8537123
name: Functional bio-inspired nanomachines from sticky colloids
publication: arXiv
publication_status: draft
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title: Controlling energy delivery with bistable nanostructures
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---
OA_place: publisher
_id: '22857'
abstract:
- lang: eng
text: "Artificial intelligence and machine learning have undergone an unprecedented
evolution in the past decade, motivating a research effort toward a theory able
to capture the qualitative behavior of large-scale neural systems. A central puzzle
has been the clear benefit of scaling architecture size and overfitting the training
set in supervised learning tasks. This evidence, in apparent contradiction with
classical statistical learning theory, pushed researchers to develop a new theory
capturing the interplay between the algorithmic and architectural bias of training
and the specific target function, differently from previous methods rooted in
uniform stability.\r\nThis approach has enabled a grounded understanding of novel
learning regimes, typically through formal limits where the number of training
samples $n$, data dimensions $d$, and model parameters $p$ grow to infinity at
different rates. \\\\\r\nIn this thesis, we follow this approach, focusing on
the trustworthiness of high-dimensional models: properties that are difficult
to control during training or deployment and often emerge under unpredictable
or adversarial conditions. In such settings, it is crucial to formally ensure
a priori the reliability of machine learning systems.\r\nFirst, we study data
memorization, both as label fitting and as the storage of private information
about training samples in trained parameters. We prove that $p = \\Omega(n)$ parameters
are sufficient for a deep neural network to memorize a generic set of labels,
and for a model to memorize spurious features across training data. We then give
evidence that $p = \\Omega(dn)$ parameters are instead necessary for an adversary
to reconstruct the full training set from the trained parameters.\r\nSecond, we
study robustness, both to adversarial perturbations and to distribution shift.
We first prove that $p = \\Omega(dn)$ parameters can be sufficient for a class
of neural networks to overfit the training data while guaranteeing robustness
to adversarial perturbations. Then, we focus on spurious correlations learning
in high-dimensional regression, studying the effect of the ridge regularization
parameter in the proportional regime $n = \\Theta(d)$, and connecting it via an
equivalence argument to the role of over-parameterization $p = \\Omega(n)$ in
neural networks. We also investigate the architectural bias of attention-based
networks, showing that they are sensitive to the replacement of individual words
in an embedded sentence, allowing them to generalize on sentences where the contextual
meaning depends on one or few words.\r\nFinally, we study differentially private
optimization in high-dimensional regimes. We prove that standard private gradient
methods do not suffer in the over-parameterized regime $p = \\Omega(n)$, challenging
the current wisdom based on stability-derived generalization bounds. We then consider
linear regression in the proportional regime $n = \\Theta(d)$, showing that standard
private gradient descent can achieve optimal rates under appropriate hyper-parameter
scaling, such as sufficiently small gradient clipping constants, whose role is
still debated in practice."
acknowledged_ssus:
- _id: ScienComp
acknowledgement: "This project was partially supported by the 2019 Lopez-Loreta prize,\r\nthe
European Union (ERC, INF2\r\n, project number 101161364), the Austrian Science Fund\r\n(FWF)
10.55776/COE12, and a Google PhD fellowship in machine intelligence. Furthermore,\r\nthe
candidate acknowledges the support from the Scientific Service Units of the Institute
of\r\nScience and Technology Austria through resources provided by Scientific Computing."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Simone
full_name: Bombari, Simone
id: ca726dda-de17-11ea-bc14-f9da834f63aa
last_name: Bombari
citation:
ama: Bombari S. Trustworthy machine learning in high dimensions. 2026. doi:10.15479/AT-ISTA-22857
apa: Bombari, S. (2026). Trustworthy machine learning in high dimensions.
Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-22857
chicago: Bombari, Simone. “Trustworthy Machine Learning in High Dimensions.” Institute
of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-22857.
ieee: S. Bombari, “Trustworthy machine learning in high dimensions,” Institute of
Science and Technology Austria, 2026.
ista: Bombari S. 2026. Trustworthy machine learning in high dimensions. Institute
of Science and Technology Austria.
mla: Bombari, Simone. Trustworthy Machine Learning in High Dimensions. Institute
of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-22857.
short: S. Bombari, Trustworthy Machine Learning in High Dimensions, Institute of
Science and Technology Austria, 2026.
corr_author: '1'
das_tickbox: '0'
date_created: 2026-09-08T13:40:08Z
date_published: 2026-09-08T00:00:00Z
date_updated: 2026-09-21T13:07:01Z
day: '08'
ddc:
- '519'
degree_awarded: PhD
department:
- _id: GradSch
- _id: MaMo
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doi_confirm: '1'
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file_date_updated: 2026-09-10T10:03:48Z
fulldoi: https://doi.org/10.15479/AT-ISTA-22857
has_accepted_license: '1'
keyword:
- machine learning
- high-dimensional statistics
- deep learning theory
- privacy
- memorization
- robustness
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '446'
project:
- _id: 92099302-16d5-11f0-9cad-f9a785f54fbd
name: 'Trustworthy Deep Learning Theory: Private Over-Parameterized Models and Robust
LLMs'
- _id: 911e6d1f-16d5-11f0-9cad-c5c68c6a1cdf
grant_number: '101161364'
name: 'Inference in High Dimensions: Light-speed Algorithms and Information Limits'
- _id: 74caaef7-b034-11f1-8f2d-e0e993bb422e
grant_number: COE12
name: Bilateral Artificial Intelligence (Mondelli)
publication_identifier:
isbn:
- 978-3-99078-091-6
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
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status: public
- id: '12859'
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researchdata_availability: no
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supervisor:
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full_name: Mondelli, Marco
id: 27EB676C-8706-11E9-9510-7717E6697425
last_name: Mondelli
orcid: 0000-0002-3242-7020
supplementarymaterial: no
title: Trustworthy machine learning in high dimensions
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2026'
...
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OA_place: publisher
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abstract:
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text: "Large-scale deep learning models are known to memorize parts of the training\r\nset.
In machine learning theory, memorization is often framed as interpolation or\r\nlabel
fitting, and classical results show that this can be achieved when the number\r\nof
parameters p in the model is larger than the number of training samples n. In\r\nthis
work, we consider memorization from the perspective of data reconstruction,\r\ndemonstrating
that this can be achieved when p is larger than dn, where d is\r\nthe dimensionality
of the data. More specifically, we show that, in the random\r\nfeatures model,
when p ≫ dn, the subspace spanned by the training samples in\r\nfeature space
gives sufficient information to identify the individual samples in input\r\nspace.
Our analysis suggests an optimization method to reconstruct the dataset\r\nfrom
the model parameters, and we demonstrate that this method performs well on\r\nvarious
architectures (random features, two-layer fully-connected and deep residual\r\nnetworks).
Our results reveal a law of data reconstruction, according to which the\r\nentire
training dataset can be recovered as p exceeds the threshold dn.\r\n"
acknowledgement: "M.M. is funded by the European Union (ERC, INF2\r\n, project number
101161364). S.B. was supported\r\nby a Google PhD fellowship. L.I. acknowledges
the grant received from the European Union NextGenerationEU (Piano Nazionale di
Ripresa E Resilienza (PNRR)) DM 351 on Trustworthy AI. T.T. &\r\nL.I. acknowledge
the EU project ELSA - European Lighthouse on Secure and Safe AI. This study was\r\ncarried
out within the FAIR - Future Artificial Intelligence Research and received funding
from the\r\nEuropean Union Next-GenerationEU (PIANO NAZIONALE DI RIPRESA E RESILIENZA
(PNRR)\r\n– MISSIONE 4 COMPONENTE 2, INVESTIMENTO 1.3 – D.D. 1555 11/10/2022, PE00000013).\r\nThis
manuscript reflects only the authors’ views and opinions, neither the European Union
nor the\r\nEuropean Commission can be considered responsible for them. The authors
would like to thank\r\nYizhe Zhu for helpful discussions."
article_processing_charge: No
arxiv: 1
author:
- first_name: Leonardo
full_name: Iurada, Leonardo
last_name: Iurada
- first_name: Simone
full_name: Bombari, Simone
id: ca726dda-de17-11ea-bc14-f9da834f63aa
last_name: Bombari
- first_name: Tatiana
full_name: Tommasi, Tatiana
last_name: Tommasi
- first_name: Marco
full_name: Mondelli, Marco
id: 27EB676C-8706-11E9-9510-7717E6697425
last_name: Mondelli
orcid: 0000-0002-3242-7020
citation:
ama: 'Iurada L, Bombari S, Tommasi T, Mondelli M. A law of data reconstruction for
random features (and beyond). In: 14th International Conference on Learning
Representations. Vol 2026. OpenReview; 2026:145275-145314.'
apa: 'Iurada, L., Bombari, S., Tommasi, T., & Mondelli, M. (2026). A law of
data reconstruction for random features (and beyond). In 14th International
Conference on Learning Representations (Vol. 2026, pp. 145275–145314). Rio
de Janeiro, Brazil: OpenReview.'
chicago: Iurada, Leonardo, Simone Bombari, Tatiana Tommasi, and Marco Mondelli.
“A Law of Data Reconstruction for Random Features (and Beyond).” In 14th International
Conference on Learning Representations, 2026:145275–314. OpenReview, 2026.
ieee: L. Iurada, S. Bombari, T. Tommasi, and M. Mondelli, “A law of data reconstruction
for random features (and beyond),” in 14th International Conference on Learning
Representations, Rio de Janeiro, Brazil, 2026, vol. 2026, pp. 145275–145314.
ista: 'Iurada L, Bombari S, Tommasi T, Mondelli M. 2026. A law of data reconstruction
for random features (and beyond). 14th International Conference on Learning Representations.
ICLR: International Conference on Learning Representations vol. 2026, 145275–145314.'
mla: Iurada, Leonardo, et al. “A Law of Data Reconstruction for Random Features
(and Beyond).” 14th International Conference on Learning Representations,
vol. 2026, OpenReview, 2026, pp. 145275–314.
short: L. Iurada, S. Bombari, T. Tommasi, M. Mondelli, in:, 14th International Conference
on Learning Representations, OpenReview, 2026, pp. 145275–145314.
conference:
end_date: 2026-04-27
location: Rio de Janeiro, Brazil
name: 'ICLR: International Conference on Learning Representations '
start_date: 2026-04-23
corr_author: '1'
das_tickbox: '0'
date_created: 2026-09-09T13:31:46Z
date_published: 2026-01-26T00:00:00Z
date_updated: 2026-09-21T13:07:01Z
day: '26'
ddc:
- '000'
department:
- _id: GradSch
- _id: MaMo
external_id:
arxiv:
- '2509.22214'
file:
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checksum: a3dcba6649b7496124fa0ae68bf2c4cb
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intvolume: ' 2026'
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month: '01'
oa: 1
oa_version: Published Version
page: 145275-145314
project:
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grant_number: '101161364'
name: 'Inference in High Dimensions: Light-speed Algorithms and Information Limits'
- _id: 92099302-16d5-11f0-9cad-f9a785f54fbd
name: 'Trustworthy Deep Learning Theory: Private Over-Parameterized Models and Robust
LLMs'
publication: 14th International Conference on Learning Representations
publication_identifier:
isbn:
- '9798331339678'
publication_status: published
publisher: OpenReview
quality_controlled: '1'
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relation: dissertation_contains
status: public
status: public
title: A law of data reconstruction for random features (and beyond)
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 2026
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '22950'
abstract:
- lang: eng
text: 'Little red dots (LRDs) are compact, red sources discovered by JWST at high
redshift (z ≳ 4), marked by distinctive “V-shaped” spectral energy distributions
(SEDs) and often interpreted as rapidly accreting active galactic nuclei (AGNs).
Their true nature remains unclear though, and their evolutionary connection to
their lower-redshift counterparts is still poorly constrained. Thus, we present
WISEA J123635.56+621424.2 (here dubbed the Saguaro), a z = 2.0145 galaxy in GOODS-North,
as a possible analog of high-redshift LRDs and a potential missing link in their
evolutionary path toward lower-redshift systems. It features a compact LRD-like
nucleus surrounded by a face-on spiral host. Its connections to LRDs include the
following: (1) its nuclear spectrum shows a clear “V-shaped” SED, and (2) when
redshifted to z = 7, surface brightness dimming makes the host undetectable, thus
mimicking an LRD. This suggests that high-redshift LRDs may be embedded in extended
hosts. To test this, we stack rest-frame UV images of 99 photometrically selected
LRDs, revealing faint, diffuse emission. Stacking in redshift bins reveals mild
radial growth, consistent with the expected galaxy size evolution. A simple analytic
model confirms that surface brightness dimming alone can explain their compact
appearance. Lastly, we show that the Saguaro is not unique by describing similar
objects from the literature at z ≲ 3.5. Taken together, our results support a
scenario in which LRDs may not be a distinct population, but could be the visible
nuclei of galaxies undergoing a short-lived, (perhaps) AGN-dominated evolutionary
phase, with their compact, red appearance driven largely by observational biases.'
acknowledgement: "The authors thank the anonymous referee for constructive comments,
which helped improve the manuscript. The authors also thank Xiaohui Fan, Xiaojing
Lin, Camilla Pacifici, Marianna Annunziatella, Claudia Scarlata, Luis C. Ho, and
Pablo G. Pérez-González for valuable discussions.\r\n\r\nThis work is based on observations
made with the NASA/ESA/CSA JWST. The data were obtained from the Mikulski Archive
for Space Telescopes (MAST) at the Space Telescope Science Institute, which is operated
by the Association of Universities for Research in Astronomy, Inc., under NASA contract
NAS 5-03127 for JWST. These observations are associated with JWST programs GTO #1181,
GTO #1211, GO #1895, GO #3577, and GO #6434 (F. Sun et al. 2025).\r\n\r\nSome of
the data products presented herein were retrieved from the Dawn JWST Archive (DJA).
DJA is an initiative of the Cosmic Dawn Center (DAWN), which is funded by the Danish
National Research Foundation under grant DNRF140.\r\n\r\nThis research has made
use of data obtained from the Chandra Data Archive provided by the Chandra X-ray
Center (CXC).\r\n\r\nThe authors acknowledge the FRESCO team led by PI P. Oesch
for developing their observing program with a zero-exclusive-access period. Processing
for the JADES NIRCam data release was performed on the lux cluster at the University
of California, Santa Cruz, funded by NSF MRI grant AST 1828315. Also based on observations
made with the NASA/ESA Hubble Space Telescope obtained from the Space Telescope
Science Institute, which is operated by the Association of Universities for Research
in Astronomy, Inc., under NASA contract NAS 526555. The data (G. Illingworth 2015;
P. Oesch & D. Magee 2023; M. Rieke et al. 2023a; F. Sun & E. Egami 2025) presented
in this article were obtained from MAST at the Space Telescope Science Institute.\r\n\r\nThe
authors acknowledge use of the lux supercomputer at UC Santa Cruz, funded by NSF
MRI grant AST 1828315.\r\n\r\nThe work of G.H.R. and P.R. was also supported by
grant 80NSSC18K0555, from NASA Goddard Space Flight Center to the University of
Arizona.\r\n\r\nA.J.B. acknowledges funding from the “FirstGalaxies” Advanced grant
from the European Research Council (ERC) under the European Union’s Horizon 2020
research and innovation program (grant agreement No. 789056)\r\n\r\nB.E.R. acknowledges
support from the NIRCam Science Team contract to the University of Arizona, NAS5-02015,
and JWST Program 3215.\r\n\r\nThe research of C.C.W. is supported by NOIRLab, which
is managed by the Association of Universities for Research in Astronomy (AURA) under
a cooperative agreement with the National Science Foundation.\r\n\r\nS.C. acknowledges
support by the European Union’s HE ERC Starting grant No. 101040227 - WINGS.\r\n\r\nY.Z.,
Z.J., B.D.J., C.N.A.W., and P.R. gratefully acknowledge the JWST/NIRCam contract
to the University of Arizona NAS5-02015.\r\n\r\nS.A. acknowledges support from the
JWST Mid-Infrared Instrument (MIRI) Science Team Lead, grant 80NSSC18K0555, from
NASA Goddard Space Flight Center to the University of Arizona.\r\n\r\nR.M., F.D.E.
acknowledge support by the Science and Technology Facilities Council (STFC), by
the ERC through Advanced grant 695671 “QUENCH,” and by the UKRI Frontier Research
grant RISEandFALL. R.M. also acknowledges funding from a research professorship
from the Royal Society.\r\n\r\nL.B. acknowledges financial support from the Inter-University
Institute for Data Intensive Astronomy (IDIA), a partnership of the University of
Cape Town, the University of Pretoria and the University of the Western Cape, and
from the South African Department of Science and Innovation’s National Research
Foundation under the ISARP RADIOMAP+ Joint Research Scheme (DSI-NRF grant No. 150551)
and the CPRR HIPPO Project (DSI-NRF grant No. SRUG22031677). C.J.E.G. acknowledges
the financial assistance of the South African Radio Astronomy Observatory (SARAO)
(www.sarao.ac.za)."
article_number: '205'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Pierluigi
full_name: Rinaldi, Pierluigi
last_name: Rinaldi
- first_name: George H.
full_name: Rieke, George H.
last_name: Rieke
- first_name: Zihao
full_name: Wu, Zihao
last_name: Wu
- first_name: Carys J. E.
full_name: Gilbert, Carys J. E.
last_name: Gilbert
- first_name: Fabio
full_name: Pacucci, Fabio
last_name: Pacucci
- first_name: Luigi
full_name: Barchiesi, Luigi
last_name: Barchiesi
- first_name: Stacey
full_name: Alberts, Stacey
last_name: Alberts
- first_name: Stefano
full_name: Carniani, Stefano
last_name: Carniani
- first_name: Andrew J.
full_name: Bunker, Andrew J.
last_name: Bunker
- first_name: Rachana
full_name: Bhatawdekar, Rachana
last_name: Bhatawdekar
- first_name: Francesco
full_name: D’Eugenio, Francesco
last_name: D’Eugenio
- first_name: Zhiyuan
full_name: Ji, Zhiyuan
last_name: Ji
- first_name: Benjamin D.
full_name: Johnson, Benjamin D.
last_name: Johnson
- first_name: Kevin
full_name: Hainline, Kevin
last_name: Hainline
- first_name: Vasily
full_name: Kokorev, Vasily
last_name: Kokorev
- first_name: Nimisha
full_name: Kumari, Nimisha
last_name: Kumari
- first_name: Edoardo
full_name: Iani, Edoardo
id: 4053390a-6b68-11ef-9828-a3b8adef8d0a
last_name: Iani
orcid: 0000-0001-8386-3546
- first_name: Jianwei
full_name: Lyu, Jianwei
last_name: Lyu
- first_name: Roberto
full_name: Maiolino, Roberto
last_name: Maiolino
- first_name: Eleonora
full_name: Parlanti, Eleonora
last_name: Parlanti
- first_name: Brant E.
full_name: Robertson, Brant E.
last_name: Robertson
- first_name: Yang
full_name: Sun, Yang
last_name: Sun
- first_name: Cristian
full_name: Vignali, Cristian
last_name: Vignali
- first_name: Christina C.
full_name: Williams, Christina C.
last_name: Williams
- first_name: Christopher N. A.
full_name: Willmer, Christopher N. A.
last_name: Willmer
- first_name: Yongda
full_name: Zhu, Yongda
last_name: Zhu
citation:
ama: 'Rinaldi P, Rieke GH, Wu Z, et al. Beyond the dot: An LRD-like nucleus at the
heart of an IR-bright galaxy and its implications for high-redshift LRDs. The
Astrophysical Journal. 2026;1006(2). doi:10.3847/1538-4357/ae80cd'
apa: 'Rinaldi, P., Rieke, G. H., Wu, Z., Gilbert, C. J. E., Pacucci, F., Barchiesi,
L., … Zhu, Y. (2026). Beyond the dot: An LRD-like nucleus at the heart of an IR-bright
galaxy and its implications for high-redshift LRDs. The Astrophysical Journal.
IOP Publishing. https://doi.org/10.3847/1538-4357/ae80cd'
chicago: 'Rinaldi, Pierluigi, George H. Rieke, Zihao Wu, Carys J. E. Gilbert, Fabio
Pacucci, Luigi Barchiesi, Stacey Alberts, et al. “Beyond the Dot: An LRD-like
Nucleus at the Heart of an IR-Bright Galaxy and Its Implications for High-Redshift
LRDs.” The Astrophysical Journal. IOP Publishing, 2026. https://doi.org/10.3847/1538-4357/ae80cd.'
ieee: 'P. Rinaldi et al., “Beyond the dot: An LRD-like nucleus at the heart
of an IR-bright galaxy and its implications for high-redshift LRDs,” The Astrophysical
Journal, vol. 1006, no. 2. IOP Publishing, 2026.'
ista: 'Rinaldi P, Rieke GH, Wu Z, Gilbert CJE, Pacucci F, Barchiesi L, Alberts S,
Carniani S, Bunker AJ, Bhatawdekar R, D’Eugenio F, Ji Z, Johnson BD, Hainline
K, Kokorev V, Kumari N, Iani E, Lyu J, Maiolino R, Parlanti E, Robertson BE, Sun
Y, Vignali C, Williams CC, Willmer CNA, Zhu Y. 2026. Beyond the dot: An LRD-like
nucleus at the heart of an IR-bright galaxy and its implications for high-redshift
LRDs. The Astrophysical Journal. 1006(2), 205.'
mla: 'Rinaldi, Pierluigi, et al. “Beyond the Dot: An LRD-like Nucleus at the Heart
of an IR-Bright Galaxy and Its Implications for High-Redshift LRDs.” The Astrophysical
Journal, vol. 1006, no. 2, 205, IOP Publishing, 2026, doi:10.3847/1538-4357/ae80cd.'
short: P. Rinaldi, G.H. Rieke, Z. Wu, C.J.E. Gilbert, F. Pacucci, L. Barchiesi,
S. Alberts, S. Carniani, A.J. Bunker, R. Bhatawdekar, F. D’Eugenio, Z. Ji, B.D.
Johnson, K. Hainline, V. Kokorev, N. Kumari, E. Iani, J. Lyu, R. Maiolino, E.
Parlanti, B.E. Robertson, Y. Sun, C. Vignali, C.C. Williams, C.N.A. Willmer, Y.
Zhu, The Astrophysical Journal 1006 (2026).
das_tickbox: '1'
dataavailabilitystatement: "Facilities: CXO - Chandra X-ray Observatory satellite,
HST - Hubble Space Telescope satellite, JWST - James Webb Space Telescope.\r\n\r\nSoftware:
Astropy (Astropy Collaboration et al. 2022), Bagpipes (A. C. Carnall et al. 2019),
MSAEXP (G. Brammer 2023)NumPy (C. R. Harris et al. 2020), pandas (T. p. d team 2024)Photutils
(L. Bradley et al. 2016), TOPCAT (M. Taylor 2022), CIAO (A. Fruscione et al. 2006),
XSpec (K. Arnaud et al. 1999), STPSF (M. D. Perrin et al. 2014)."
date_created: 2026-09-17T11:05:32Z
date_published: 2026-07-29T00:00:00Z
date_updated: 2026-09-22T06:14:37Z
day: '29'
ddc:
- '520'
department:
- _id: JoMa
doi: 10.3847/1538-4357/ae80cd
external_id:
arxiv:
- '2507.17738'
file:
- access_level: open_access
checksum: ef77723c7b0fa7f82085eba8caec0cf3
content_type: application/pdf
creator: dernst
date_created: 2026-09-22T06:13:50Z
date_updated: 2026-09-22T06:13:50Z
file_id: '22979'
file_name: 2026_AstrophysicalJour_Rinaldi.pdf
file_size: 6154775
relation: main_file
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file_date_updated: 2026-09-22T06:13:50Z
fulldoi: https://doi.org/10.3847/1538-4357/ae80cd
has_accepted_license: '1'
intvolume: ' 1006'
issue: '2'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: 'Beyond the dot: An LRD-like nucleus at the heart of an IR-bright galaxy and
its implications for high-redshift LRDs'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1006
year: '2026'
...
---
OA_place: publisher
OA_type: gold
_id: '22921'
abstract:
- lang: eng
text: 'Runtime monitoring of quantitative signals faces a fundamental trade-off
between volatility and over-aggregation: instantaneous observations are noisy,
while long-run averages obscure local structure. Localisation measures such as
discounted averages offer a principled middle ground, yet remain poorly understood
in runtime verification. This paper studies discounted sums from a monitoring
perspective, in both deterministic and stochastic settings. We formalize the discounted
monitoring problem and show that exact, sound monitoring of discounted sums cannot
be achieved with finite memory. To overcome this impossibility, we introduce ε-approximately
sound monitoring, deriving explicit bounds on memory and observation requirements.
We then extend the framework to stochastic processes via expected discounted sums,
defining pointwise and uniform (ε,δ)-soundness notions, establishing statistical
optimality, and proving impossibility beyond a precision threshold. We also formalize
the resource complexity of deterministic discounted monitoring via affine register
machines and prove a tight worst-case lower bound. Finally, we present a specification
language for arithmetic expressions over multiple discounted sums with synchronous
and asynchronous semantics, and evaluate our approach on practical scenarios including
algorithmic fairness.'
acknowledgement: "This work has been supported by the European Research Council under
Grant No.: ERC2020-AdG 101020093 and ERC-2021-AdG 101055412.\r\nFilip Cano: ERC-2020-AdG
101020093\r\nThomas A. Henzinger: ERC-2020-AdG 101020093\r\nKonstantin Kueffner:
ERC-2020-AdG 101020093\r\nN. Ege Saraç: ERC-2021-AdG 101055412"
alternative_title:
- LIPIcs
article_number: 22:1-22:19
article_processing_charge: Yes
arxiv: 1
author:
- first_name: Filip
full_name: Cano Cordoba, Filip
id: 708cad98-e86a-11ef-8098-bdae2d7c6af1
last_name: Cano Cordoba
orcid: 0000-0002-0783-904X
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
- first_name: Konstantin
full_name: Kueffner, Konstantin
id: 8121a2d0-dc85-11ea-9058-af578f3b4515
last_name: Kueffner
orcid: 0000-0001-8974-2542
- first_name: Naci E
full_name: Sarac, Naci E
id: 8C6B42F8-C8E6-11E9-A03A-F2DCE5697425
last_name: Sarac
citation:
ama: 'Cano Cordoba F, Henzinger TA, Kueffner K, Sarac NE. Monitoring discounted
sum properties. In: 37th International Conference on Concurrency Theory.
Vol 391. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2026. doi:10.4230/LIPIcs.CONCUR.2026.22'
apa: 'Cano Cordoba, F., Henzinger, T. A., Kueffner, K., & Sarac, N. E. (2026).
Monitoring discounted sum properties. In 37th International Conference on Concurrency
Theory (Vol. 391). Liverpool, United Kingdom: Schloss Dagstuhl - Leibniz-Zentrum
für Informatik. https://doi.org/10.4230/LIPIcs.CONCUR.2026.22'
chicago: Cano Cordoba, Filip, Thomas A Henzinger, Konstantin Kueffner, and Naci
E Sarac. “Monitoring Discounted Sum Properties.” In 37th International Conference
on Concurrency Theory, Vol. 391. Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2026. https://doi.org/10.4230/LIPIcs.CONCUR.2026.22.
ieee: F. Cano Cordoba, T. A. Henzinger, K. Kueffner, and N. E. Sarac, “Monitoring
discounted sum properties,” in 37th International Conference on Concurrency
Theory, Liverpool, United Kingdom, 2026, vol. 391.
ista: 'Cano Cordoba F, Henzinger TA, Kueffner K, Sarac NE. 2026. Monitoring discounted
sum properties. 37th International Conference on Concurrency Theory. CONCUR: Conference
on Concurrency Theory, LIPIcs, vol. 391, 22:1-22:19.'
mla: Cano Cordoba, Filip, et al. “Monitoring Discounted Sum Properties.” 37th
International Conference on Concurrency Theory, vol. 391, 22:1-22:19, Schloss
Dagstuhl - Leibniz-Zentrum für Informatik, 2026, doi:10.4230/LIPIcs.CONCUR.2026.22.
short: F. Cano Cordoba, T.A. Henzinger, K. Kueffner, N.E. Sarac, in:, 37th International
Conference on Concurrency Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2026.
conference:
end_date: 2026-09-04
location: Liverpool, United Kingdom
name: 'CONCUR: Conference on Concurrency Theory'
start_date: 2026-09-01
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: "Software (Source Code): https://github.com/filipcano/monitoringdiscounted-sum-properties
[10]\r\narchived at swh:1:dir:cb99396415f279c985cd05206b44320227f64245\r\n"
date_created: 2026-09-13T22:01:54Z
date_published: 2026-08-24T00:00:00Z
date_updated: 2026-09-22T06:02:06Z
day: '24'
ddc:
- '000'
department:
- _id: ToHe
- _id: GradSch
doi: 10.4230/LIPIcs.CONCUR.2026.22
ec_funded: 1
external_id:
arxiv:
- '2606.25979'
file:
- access_level: open_access
checksum: f7b2e22428344fd7972c54f099df6aba
content_type: application/pdf
creator: dernst
date_created: 2026-09-22T05:59:03Z
date_updated: 2026-09-22T05:59:03Z
file_id: '22978'
file_name: 2026_LIPIcsCONCUR_Cano.pdf
file_size: 997156
relation: main_file
success: 1
file_date_updated: 2026-09-22T05:59:03Z
fulldoi: https://doi.org/10.4230/LIPIcs.CONCUR.2026.22
has_accepted_license: '1'
intvolume: ' 391'
keyword:
- Runtime Verification
- Probabilistic Systems
- Quantitative Verification
- Approximate Monitoring
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 62781420-2b32-11ec-9570-8d9b63373d4d
call_identifier: H2020
grant_number: '101020093'
name: Vigilant Algorithmic Monitoring of Software
publication: 37th International Conference on Concurrency Theory
publication_identifier:
isbn:
- '9783959774475'
issn:
- 1868-8969
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Monitoring discounted sum properties
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 391
year: '2026'
...
---
OA_place: publisher
OA_type: gold
_id: '22922'
abstract:
- lang: eng
text: In this note, we recall the history and our motivation behind the development
of Strategy Logic and we discuss some of the work that ensued from its introduction.
acknowledgement: " Krishnendu Chatterjee: Supported in part by the Austrian Science
Fund (FWF) COE\r\ngrant 10.55776/COE12 and the ERC CoG 863818 (ForM-SMArt).\r\nThomas
A. Henzinger: Supported in part by the ERC AdG 101020093 (VAMOS) and the FWF\r\nSFB
grant F8502 (SPyCoDe).\r\nNir Piterman: Supported in part by the Swedish research
council (VR) project no. 2025-05419 and\r\nthe Wallenberg AI, Autonomous Systems
and Software Program (WASP) funded by the Knut and\r\nAlice Wallenberg Foundation.\r\nAcknowledgements
We thank the jury that our paper introducing Strategy Logic at the Conference\r\non
Concurrency Theory (CONCUR) 2007 [10] was chosen for a CONCUR Test-of-Time Award
at\r\nCONCUR 2026."
alternative_title:
- LIPIcs
article_number: 6:1-6:7
article_processing_charge: Yes
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
- first_name: Nir
full_name: Piterman, Nir
last_name: Piterman
citation:
ama: 'Chatterjee K, Henzinger TA, Piterman N. A look back at strategy logic. In:
37th International Conference on Concurrency Theory. Vol 391. Schloss Dagstuhl
- Leibniz-Zentrum für Informatik; 2026. doi:10.4230/LIPIcs.CONCUR.2026.6'
apa: 'Chatterjee, K., Henzinger, T. A., & Piterman, N. (2026). A look back at
strategy logic. In 37th International Conference on Concurrency Theory
(Vol. 391). Liverpool, United Kingdom: Schloss Dagstuhl - Leibniz-Zentrum für
Informatik. https://doi.org/10.4230/LIPIcs.CONCUR.2026.6'
chicago: Chatterjee, Krishnendu, Thomas A Henzinger, and Nir Piterman. “A Look Back
at Strategy Logic.” In 37th International Conference on Concurrency Theory,
Vol. 391. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2026. https://doi.org/10.4230/LIPIcs.CONCUR.2026.6.
ieee: K. Chatterjee, T. A. Henzinger, and N. Piterman, “A look back at strategy
logic,” in 37th International Conference on Concurrency Theory, Liverpool,
United Kingdom, 2026, vol. 391.
ista: 'Chatterjee K, Henzinger TA, Piterman N. 2026. A look back at strategy logic.
37th International Conference on Concurrency Theory. CONCUR: Conference on Concurrency
Theory, LIPIcs, vol. 391, 6:1-6:7.'
mla: Chatterjee, Krishnendu, et al. “A Look Back at Strategy Logic.” 37th International
Conference on Concurrency Theory, vol. 391, 6:1-6:7, Schloss Dagstuhl - Leibniz-Zentrum
für Informatik, 2026, doi:10.4230/LIPIcs.CONCUR.2026.6.
short: K. Chatterjee, T.A. Henzinger, N. Piterman, in:, 37th International Conference
on Concurrency Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2026.
conference:
end_date: 2026-09-04
location: Liverpool, United Kingdom
name: 'CONCUR: Conference on Concurrency Theory'
start_date: 2026-09-01
corr_author: '1'
das_tickbox: '0'
date_created: 2026-09-13T22:01:54Z
date_published: 2026-08-24T00:00:00Z
date_updated: 2026-09-22T05:54:30Z
day: '24'
ddc:
- '000'
department:
- _id: KrCh
- _id: ToHe
doi: 10.4230/LIPIcs.CONCUR.2026.6
ec_funded: 1
file:
- access_level: open_access
checksum: f3995df175701f56a702bdb012e4f710
content_type: application/pdf
creator: dernst
date_created: 2026-09-22T05:53:16Z
date_updated: 2026-09-22T05:53:16Z
file_id: '22977'
file_name: 2026_LIPIcsCONCUR_Chatterjee.pdf
file_size: 517651
relation: main_file
success: 1
file_date_updated: 2026-09-22T05:53:16Z
fulldoi: https://doi.org/10.4230/LIPIcs.CONCUR.2026.6
has_accepted_license: '1'
intvolume: ' 391'
keyword:
- Strategy Logic
- Games
- Automata
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 4029cfc7-b034-11f1-9e55-88ab2ff3b6ee
grant_number: COE12
name: Bilateral Artificial Intelligence (Chatterjee)
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '863818'
name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
- _id: 62781420-2b32-11ec-9570-8d9b63373d4d
call_identifier: H2020
grant_number: '101020093'
name: Vigilant Algorithmic Monitoring of Software
- _id: 34a1b658-11ca-11ed-8bc3-c75229f0241e
grant_number: F8502
name: Interface Theory for Security and Privacy
publication: 37th International Conference on Concurrency Theory
publication_identifier:
isbn:
- '9783959774475'
issn:
- 1868-8969
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: A look back at strategy logic
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 391
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '22951'
abstract:
- lang: eng
text: Anesthesia recovery is critical for resuming normal physiological and neuronal
functions; however, the mechanisms involved remain elusive. Here, we identify
a female-selective corticosterone-mediated microglia-neuron interaction during
ketamine anesthesia recovery, absent in males. This microglia-neuron interaction
induces plastic and functional neuronal changes, as evidenced by increased mEPSC
frequency, which was occluded upon microglia depletion. We showed that this process
is driven through up-regulation of the stress-responsive co-chaperone Fkbp5 mRNA
and its protein, Fkbp51, in female microglia. Fkbp5/Fkbp51 is a key intermediary
in a corticosteroid-induced stress response, and its involvement points toward
a critical interface between endocrine signaling and microglia. To counteract
the observed ketamine anesthesia-mediated increase in blood corticosterone during
recovery, we removed the primary source of corticosterone by adrenalectomy. Close
microglia-neuron interaction was reduced and increased again following corticosterone
injection. Our findings identify a sex-specific microglia-mediated mechanism of
neuronal plasticity during anesthesia recovery, driven by corticosterone, thereby
enhancing our understanding of sex differences in brain function.
acknowledged_ssus:
- _id: Bio
- _id: M-Shop
- _id: PreCl
- _id: LifeSc
acknowledgement: "We thank the scientific service units at ISTA, especially the imaging
optic facility (IOF), the machine shop (Miba), specifically T. Asenov, the preclinical
facility (PCF), specifically M. Schunn and S. Haslinger, C. Jansen for bioinformatic
support, and the laboratory support facility (LSF). We also thank M. Benevento for
supporting the design and partial performance of electrophysiology and fluorescence
in situ hybridization experiments and for extensive discussions about the manuscript
draft, R. Schulz and G. Colombo for advice on morphological reconstruction, M. Schmidt
for valuable discussions about Fkbp5, and all Siegert team members for constant
feedback on the project and manuscript. Grammarly was used to assist with grammatical
revisions. We specifically acknowledge the following experimental contributions:
R.J.A.C. (Multiome quality control), P.K. (electrophysiology), B.T., C.T.J.V., K.J.
(multiome), J.Y. (KXA estimates), M.A. and T.N. (morphOMICs).\r\nA.V., M.A., T.N.,
R.J.A.C., J.Y., P.K., and S.S. were supported by the Institute of Science and Technology
Austria. C.T.J.V., K.J., and B.T. were supported by the Allen Institute."
article_number: eadz6517
article_processing_charge: Yes
article_type: original
author:
- first_name: Alessandro
full_name: Venturino, Alessandro
id: 41CB84B2-F248-11E8-B48F-1D18A9856A87
last_name: Venturino
orcid: 0000-0003-2356-9403
- first_name: Amin
full_name: Alam, Amin
id: 65a3f615-b651-11f1-9c4b-da4396a4174a
last_name: Alam
- first_name: Thomas
full_name: Negrello, Thomas
id: 37d68bf2-b651-11f1-b680-ec86ff9a70f3
last_name: Negrello
- first_name: Kelly
full_name: Jin, Kelly
last_name: Jin
- first_name: Cindy T. J.
full_name: van Velthoven, Cindy T. J.
last_name: van Velthoven
- first_name: Ryan J
full_name: Cubero, Ryan J
id: 850B2E12-9CD4-11E9-837F-E719E6697425
last_name: Cubero
orcid: 0000-0003-0002-1867
- first_name: Jake
full_name: Yeung, Jake
id: 123012b2-db30-11eb-b4d8-a35840c0551b
last_name: Yeung
orcid: 0000-0003-1732-1559
- first_name: Peter
full_name: Koppensteiner, Peter
id: 3B8B25A8-F248-11E8-B48F-1D18A9856A87
last_name: Koppensteiner
orcid: 0000-0002-3509-1948
- first_name: Bosiljka
full_name: Tasic, Bosiljka
last_name: Tasic
- first_name: Sandra
full_name: Siegert, Sandra
id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
last_name: Siegert
orcid: 0000-0001-8635-0877
citation:
ama: Venturino A, Alam A, Negrello T, et al. Corticosterone-linked microglial activity
underpins sexually dimorphic neuroplasticity after ketamine anesthesia. Science
Advances. 2026;12(31). doi:10.1126/sciadv.adz6517
apa: Venturino, A., Alam, A., Negrello, T., Jin, K., van Velthoven, C. T. J., Cubero,
R. J., … Siegert, S. (2026). Corticosterone-linked microglial activity underpins
sexually dimorphic neuroplasticity after ketamine anesthesia. Science Advances.
AAAS. https://doi.org/10.1126/sciadv.adz6517
chicago: Venturino, Alessandro, Amin Alam, Thomas Negrello, Kelly Jin, Cindy T.
J. van Velthoven, Ryan J Cubero, Jake Yeung, Peter Koppensteiner, Bosiljka Tasic,
and Sandra Siegert. “Corticosterone-Linked Microglial Activity Underpins Sexually
Dimorphic Neuroplasticity after Ketamine Anesthesia.” Science Advances.
AAAS, 2026. https://doi.org/10.1126/sciadv.adz6517.
ieee: A. Venturino et al., “Corticosterone-linked microglial activity underpins
sexually dimorphic neuroplasticity after ketamine anesthesia,” Science Advances,
vol. 12, no. 31. AAAS, 2026.
ista: Venturino A, Alam A, Negrello T, Jin K, van Velthoven CTJ, Cubero RJ, Yeung
J, Koppensteiner P, Tasic B, Siegert S. 2026. Corticosterone-linked microglial
activity underpins sexually dimorphic neuroplasticity after ketamine anesthesia.
Science Advances. 12(31), eadz6517.
mla: Venturino, Alessandro, et al. “Corticosterone-Linked Microglial Activity Underpins
Sexually Dimorphic Neuroplasticity after Ketamine Anesthesia.” Science Advances,
vol. 12, no. 31, eadz6517, AAAS, 2026, doi:10.1126/sciadv.adz6517.
short: A. Venturino, A. Alam, T. Negrello, K. Jin, C.T.J. van Velthoven, R.J. Cubero,
J. Yeung, P. Koppensteiner, B. Tasic, S. Siegert, Science Advances 12 (2026).
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: 'All data and code needed to evaluate and reproduce the
results in the paper are present in the paper and/or the Supplementary Materials.
This study did not generate new materials. Transcriptional data can be accessed
at the NCBI GEO accession GSE298669. The code for the morphological analysis is
available under DOI: https://doi.org/10.5281/zenodo.19057068. The codes for the
single-nucleus analysis are accessible under DOI: 10.5281/zenodo.19019013 and DOI:
10.5281/zenodo.19071467.'
date_created: 2026-09-17T11:05:39Z
date_published: 2026-07-01T00:00:00Z
date_updated: 2026-09-22T06:56:26Z
day: '01'
ddc:
- '570'
department:
- _id: SaSi
- _id: ScienComp
- _id: PreCl
doi: 10.1126/sciadv.adz6517
external_id:
pmid:
- '42536755 '
file:
- access_level: open_access
checksum: 715a1f35a0805be85ef90556205a2cbc
content_type: application/pdf
creator: dernst
date_created: 2026-09-22T06:50:16Z
date_updated: 2026-09-22T06:50:16Z
file_id: '22980'
file_name: 2026_ScienceAdv_Venturino.pdf
file_size: 4556377
relation: main_file
success: 1
file_date_updated: 2026-09-22T06:50:16Z
fulldoi: https://doi.org/10.1126/sciadv.adz6517
has_accepted_license: '1'
intvolume: ' 12'
issue: '31'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Corticosterone-linked microglial activity underpins sexually dimorphic neuroplasticity
after ketamine anesthesia
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22955'
abstract:
- lang: eng
text: The regulation of 3D cell shape is a fundamental problem of life. In multicellular
tissues, cell shape emerges through the balance of forces inside and outside the
cell. In epithelia, the basement membrane (BM) is the first extracellular barrier
that cells sense biochemically and mechanically. Despite this, little is known
about how BM mechanical properties are regulated and how they impact cell shape.
Through mathematical modeling, we show that the stress relaxation time of the
BM can regulate cell shape. Using molecular dynamics simulations, we show that
the stress relaxation time of a collagen IV network can be inferred from the lifetime
of collagen IV molecules. To measure collagen IV lifetime in vivo, we develop
a fluorescent timer reporter for collagen IV and show that perlecan modifies collagen
IV lifetime. This cross-disciplinary approach establishes a multiscale framework
to probe matrix turnover, and its regulation and function in cell shape control.
acknowledgement: "We thank all members of the Mao lab for insightful discussions throughout
the project, and we thank Giulia Paci and Nargess Khalilgharibi for critical reading
of the manuscript. We thank Jonathan Chubb for molecular biology guidance and WellGenetics
for generating the timer protein fly lines.\r\nR.B. was funded by a UCL COMPLEX
PhD studentship and a Leverhulme Trust project grant RPG-2020-068 awarded to Y.M.
B.M. and A.S. were funded by the European Union Horizon 2020 research and innovation
programme (ERC starting grant no. 802960). S.B. was funded by NIH R35 GM143042.
G.C. was funded by EPSRC Physics of Life, grants EP/W023806 and EP/W023865. B.J.S.S.
and B.M.S. are funded by the Wellcome Trust (grant no. 301803/Z/23/Z to B.M.S.).
E.K.P. was funded by the Medical Research Council UK (MRC programme award MC_UU_12018/5).
Y.M. was funded by MRC award MR/W027437/1, a Lister Institute Research Prize, and
the EMBO Young Investigator Programme."
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Ricardo
full_name: Barrientos, Ricardo
last_name: Barrientos
- first_name: Billie
full_name: Meadowcroft, Billie
id: a4725fd6-932b-11ed-81e2-c098c7f37ae1
last_name: Meadowcroft
orcid: 0000-0003-3441-1337
- first_name: Besaiz J.
full_name: Sánchez-Sánchez, Besaiz J.
last_name: Sánchez-Sánchez
- first_name: Brian M.
full_name: Stramer, Brian M.
last_name: Stramer
- first_name: Ewa K.
full_name: Paluch, Ewa K.
last_name: Paluch
- first_name: Guillaume
full_name: Charras, Guillaume
last_name: Charras
- first_name: Shiladitya
full_name: Banerjee, Shiladitya
last_name: Banerjee
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Yanlan
full_name: Mao, Yanlan
last_name: Mao
citation:
ama: Barrientos R, Meadowcroft B, Sánchez-Sánchez BJ, et al. Basement membrane turnover
controls cell shape. Cell. 2026;189(18):5611-5624.e4. doi:10.1016/j.cell.2026.07.010
apa: Barrientos, R., Meadowcroft, B., Sánchez-Sánchez, B. J., Stramer, B. M., Paluch,
E. K., Charras, G., … Mao, Y. (2026). Basement membrane turnover controls cell
shape. Cell. Elsevier. https://doi.org/10.1016/j.cell.2026.07.010
chicago: Barrientos, Ricardo, Billie Meadowcroft, Besaiz J. Sánchez-Sánchez, Brian
M. Stramer, Ewa K. Paluch, Guillaume Charras, Shiladitya Banerjee, Anđela Šarić,
and Yanlan Mao. “Basement Membrane Turnover Controls Cell Shape.” Cell.
Elsevier, 2026. https://doi.org/10.1016/j.cell.2026.07.010.
ieee: R. Barrientos et al., “Basement membrane turnover controls cell shape,”
Cell, vol. 189, no. 18. Elsevier, p. 5611–5624.e4, 2026.
ista: Barrientos R, Meadowcroft B, Sánchez-Sánchez BJ, Stramer BM, Paluch EK, Charras
G, Banerjee S, Šarić A, Mao Y. 2026. Basement membrane turnover controls cell
shape. Cell. 189(18), 5611–5624.e4.
mla: Barrientos, Ricardo, et al. “Basement Membrane Turnover Controls Cell Shape.”
Cell, vol. 189, no. 18, Elsevier, 2026, p. 5611–5624.e4, doi:10.1016/j.cell.2026.07.010.
short: R. Barrientos, B. Meadowcroft, B.J. Sánchez-Sánchez, B.M. Stramer, E.K. Paluch,
G. Charras, S. Banerjee, A. Šarić, Y. Mao, Cell 189 (2026) 5611–5624.e4.
das_tickbox: '1'
dataavailabilitystatement: "The fly line generated in this study is available from
the lead contact without restriction.\r\nData and code availability\r\n•\r\nCollagen
IV fluorescent timer image data and associated data analysis code have been deposited
in the UCL Research Data Repository at https://doi.org/10.5522/04/32647191 and are
publicly available as of the date of publication.\r\n•\r\nAll original code associated
with the tissue mechanics model has also been deposited in the UCL Research Data
Repository at https://doi.org/10.5522/04/32647191 and is publicly available as of
the date of publication.\r\n•\r\nAll original code associated with the collagen
IV network model has been deposited on Zenodo at https://doi.org/10.5281/zenodo.20719515
and is publicly available as of the date of publication.\r\n•\r\nAny additional
information reported in this paper is available from the lead contact upon request."
date_created: 2026-09-17T11:06:06Z
date_published: 2026-09-03T00:00:00Z
date_updated: 2026-09-24T12:36:56Z
day: '03'
ddc:
- '570'
department:
- _id: AnSa
doi: 10.1016/j.cell.2026.07.010
ec_funded: 1
external_id:
pmid:
- '42532043'
file:
- access_level: open_access
checksum: 01e74f866223ca9ea8680b617d4aa4e3
content_type: application/pdf
creator: dernst
date_created: 2026-09-24T12:35:11Z
date_updated: 2026-09-24T12:35:11Z
file_id: '22990'
file_name: 2026_Cell_Barrientos.pdf
file_size: 5642382
relation: main_file
success: 1
file_date_updated: 2026-09-24T12:35:11Z
fulldoi: https://doi.org/10.1016/j.cell.2026.07.010
has_accepted_license: '1'
intvolume: ' 189'
issue: '18'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 5611-5624.e4
pmid: 1
project:
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
call_identifier: H2020
grant_number: '802960'
name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
publication: Cell
publication_identifier:
eissn:
- 1097-4172
issn:
- 0092-8674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Basement membrane turnover controls cell shape
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 189
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '22952'
abstract:
- lang: eng
text: Mechanosensitive ion transport plays a central role in enabling living systems
to perceive and adapt to their environment through the deformation of soft, embedded
ion channels. In this work, we demonstrate that ion transport within a two-dimensional
graphite nanoslit can be rationally engineered to achieve a bipolar, pressure-sensitive
response without any structural deformation. The mechanosensitivity arises from
the selective charging of one channel inlet, which acts as a reversible source
of mobile charge carriers. These excess ions can then be advected in or out of
the channel by the pressure-driven water flow, thereby modulating the ionic conductance.
This mechanism is captured through a comprehensive electrohydrodynamic model that
analytically accounts for coupled diffusion, convection, surface transport, diffusio-osmosis,
and interfacial slippage, both inside and outside the nanoslit. The theoretical
framework quantitatively reproduces the experimental data, showing that a simple
surface charge pattern can give rise to complex, pressure-dependent conductance.
These findings reveal how rich nonlinear couplings at the nanoscale can be harnessed
to design adaptive, bioinspired nanofluidic systems, exemplified here by ionic
pressure sensors.
acknowledgement: 'We acknowledge support from eRc project n-AQUA, grant agreement
101071937. B.c. acknowledges support from the nOMiS Foundation. M.L. acknowledges
support from theAlexander von humboldt foundation. Q.Y. acknowledges support from
the Royal SocietyUniversity Research Fellowship URF\R1\221096 and UK Research and
innovation Grant (eP/X017575/1). '
article_number: eaed4451
article_processing_charge: Yes
article_type: original
author:
- first_name: Mathieu
full_name: Lizée, Mathieu
last_name: Lizée
- first_name: Zhijia
full_name: Zhang, Zhijia
last_name: Zhang
- first_name: Baptiste
full_name: Coquinot, Baptiste
id: f8417bd4-f599-11ee-a482-b927e3ed1e8e
last_name: Coquinot
orcid: 0000-0001-5524-596X
- first_name: Qian
full_name: Yang, Qian
last_name: Yang
- first_name: Lydéric
full_name: Bocquet, Lydéric
last_name: Bocquet
citation:
ama: Lizée M, Zhang Z, Coquinot B, Yang Q, Bocquet L. Architecting mechanosensitive
nanofluidic transport in graphite nanoslits. Science Advances. 2026;12(31).
doi:10.1126/sciadv.aed4451
apa: Lizée, M., Zhang, Z., Coquinot, B., Yang, Q., & Bocquet, L. (2026). Architecting
mechanosensitive nanofluidic transport in graphite nanoslits. Science Advances.
AAAS. https://doi.org/10.1126/sciadv.aed4451
chicago: Lizée, Mathieu, Zhijia Zhang, Baptiste Coquinot, Qian Yang, and Lydéric
Bocquet. “Architecting Mechanosensitive Nanofluidic Transport in Graphite Nanoslits.”
Science Advances. AAAS, 2026. https://doi.org/10.1126/sciadv.aed4451.
ieee: M. Lizée, Z. Zhang, B. Coquinot, Q. Yang, and L. Bocquet, “Architecting mechanosensitive
nanofluidic transport in graphite nanoslits,” Science Advances, vol. 12,
no. 31. AAAS, 2026.
ista: Lizée M, Zhang Z, Coquinot B, Yang Q, Bocquet L. 2026. Architecting mechanosensitive
nanofluidic transport in graphite nanoslits. Science Advances. 12(31), eaed4451.
mla: Lizée, Mathieu, et al. “Architecting Mechanosensitive Nanofluidic Transport
in Graphite Nanoslits.” Science Advances, vol. 12, no. 31, eaed4451, AAAS,
2026, doi:10.1126/sciadv.aed4451.
short: M. Lizée, Z. Zhang, B. Coquinot, Q. Yang, L. Bocquet, Science Advances 12
(2026).
das_tickbox: '1'
dataavailabilitystatement: All data needed to evaluate the conclusions in the paper
are present in the paper and/or the Supplementary Materials. no new materials have
been created for this work
date_created: 2026-09-17T11:05:47Z
date_published: 2026-07-01T00:00:00Z
date_updated: 2026-09-24T12:00:31Z
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doi: 10.1126/sciadv.aed4451
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issue: '31'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
publication: Science Advances
publication_identifier:
eissn:
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publisher: AAAS
quality_controlled: '1'
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supplementarymaterial: yes
title: Architecting mechanosensitive nanofluidic transport in graphite nanoslits
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abstract:
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text: The aim of the present paper is to propose and study a dissipative variant
of symplectic billiards within planar strictly convex domains. The associated
billiard map is dissipative, thus it admits a compact invariant set, the so-called
Birkhoff attractor. Its complexity depends on the rate of dissipation as well
as on the geometry of the billiard table. We prove that (a) for strong dissipation,
the Birkhoff attractor is a normally contracted graph over the zero section; (b)
for mild dissipation, the Birkhoff attractor within a centrally symmetric domain
is an indecomposable continuum whose restricted dynamics has positive topological
entropy. We compare these results with those for dissipative Birkhoff billiards,
studied in [15].
acknowledgement: Open access funding provided by Università degli Studi di Padova
within the CRUI-CARE Agreement. A.F. is partially supported by the ANR project CoSyDy
(ANR-CE40-0014), the ANR project GALS (ANR-23-CE40-0001) and PEPS project “Jeuns
chercheurs et jeunes chercheuses” 2025. L.B. and O.B. have been partially supported
by the PRIN project 2022FPZEES “Stability in Hamiltonian Dynamics and Beyond”.
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Luca
full_name: Baracco, Luca
last_name: Baracco
- first_name: Olga
full_name: Bernardi, Olga
last_name: Bernardi
- first_name: Anna
full_name: Florio, Anna
last_name: Florio
- first_name: Alessandra
full_name: Nardi, Alessandra
id: 3e9c89df-ff0c-11f0-9fd7-c11e36d36769
last_name: Nardi
citation:
ama: Baracco L, Bernardi O, Florio A, Nardi A. Birkhoff attractors for dissipative
symplectic billiards. Journal of Dynamics and Differential Equations. 2026.
doi:10.1007/s10884-026-10528-9
apa: Baracco, L., Bernardi, O., Florio, A., & Nardi, A. (2026). Birkhoff attractors
for dissipative symplectic billiards. Journal of Dynamics and Differential
Equations. Springer. https://doi.org/10.1007/s10884-026-10528-9
chicago: Baracco, Luca, Olga Bernardi, Anna Florio, and Alessandra Nardi. “Birkhoff
Attractors for Dissipative Symplectic Billiards.” Journal of Dynamics and Differential
Equations. Springer, 2026. https://doi.org/10.1007/s10884-026-10528-9.
ieee: L. Baracco, O. Bernardi, A. Florio, and A. Nardi, “Birkhoff attractors for
dissipative symplectic billiards,” Journal of Dynamics and Differential Equations.
Springer, 2026.
ista: Baracco L, Bernardi O, Florio A, Nardi A. 2026. Birkhoff attractors for dissipative
symplectic billiards. Journal of Dynamics and Differential Equations.
mla: Baracco, Luca, et al. “Birkhoff Attractors for Dissipative Symplectic Billiards.”
Journal of Dynamics and Differential Equations, Springer, 2026, doi:10.1007/s10884-026-10528-9.
short: L. Baracco, O. Bernardi, A. Florio, A. Nardi, Journal of Dynamics and Differential
Equations (2026).
das_tickbox: '0'
date_created: 2026-09-17T11:05:59Z
date_published: 2026-07-27T00:00:00Z
date_updated: 2026-09-24T12:26:26Z
day: '27'
ddc:
- '500'
department:
- _id: VaKa
doi: 10.1007/s10884-026-10528-9
external_id:
arxiv:
- '2509.13086'
fulldoi: https://doi.org/10.1007/s10884-026-10528-9
has_accepted_license: '1'
keyword:
- Dissipative symplectic billiard
- Birkhoff attractor
- Conformally symplectic twist map
language:
- iso: eng
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month: '07'
oa: 1
oa_version: Published Version
publication: Journal of Dynamics and Differential Equations
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eissn:
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issn:
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title: Birkhoff attractors for dissipative symplectic billiards
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image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
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type: journal_article
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...
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OA_place: repository
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abstract:
- lang: eng
text: We prove that any finitely smooth, axially symmetric, strictly convex domain
with everywhere positive curvature and sufficiently close to an ellipse is area
spectrally rigid. This means that any area-isospectral family of domains in this
class is necessarily equi-affine. We use techniques, adapted to symplectic billiards,
inspired by the paper of J. De Simoi, V. Kaloshin and Q. Wei [5].
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Luca
full_name: Baracco, Luca
last_name: Baracco
- first_name: Olga
full_name: Bernardi, Olga
last_name: Bernardi
- first_name: Alessandra
full_name: Nardi, Alessandra
id: 3e9c89df-ff0c-11f0-9fd7-c11e36d36769
last_name: Nardi
citation:
ama: Baracco L, Bernardi O, Nardi A. Area spectral rigidity for axially symmetric
symplectic billiard tables. Journal of Modern Dynamics. 2026;22:469-488.
doi:10.3934/jmd.2026012
apa: Baracco, L., Bernardi, O., & Nardi, A. (2026). Area spectral rigidity for
axially symmetric symplectic billiard tables. Journal of Modern Dynamics.
American Institute of Mathematical Sciences. https://doi.org/10.3934/jmd.2026012
chicago: Baracco, Luca, Olga Bernardi, and Alessandra Nardi. “Area Spectral Rigidity
for Axially Symmetric Symplectic Billiard Tables.” Journal of Modern Dynamics.
American Institute of Mathematical Sciences, 2026. https://doi.org/10.3934/jmd.2026012.
ieee: L. Baracco, O. Bernardi, and A. Nardi, “Area spectral rigidity for axially
symmetric symplectic billiard tables,” Journal of Modern Dynamics, vol.
22. American Institute of Mathematical Sciences, pp. 469–488, 2026.
ista: Baracco L, Bernardi O, Nardi A. 2026. Area spectral rigidity for axially symmetric
symplectic billiard tables. Journal of Modern Dynamics. 22, 469–488.
mla: Baracco, Luca, et al. “Area Spectral Rigidity for Axially Symmetric Symplectic
Billiard Tables.” Journal of Modern Dynamics, vol. 22, American Institute
of Mathematical Sciences, 2026, pp. 469–88, doi:10.3934/jmd.2026012.
short: L. Baracco, O. Bernardi, A. Nardi, Journal of Modern Dynamics 22 (2026) 469–488.
corr_author: '1'
das_tickbox: '0'
date_created: 2026-09-17T11:05:53Z
date_published: 2026-07-24T00:00:00Z
date_updated: 2026-09-24T12:12:44Z
day: '24'
department:
- _id: VaKa
doi: 10.3934/jmd.2026012
external_id:
arxiv:
- '2410.12644'
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language:
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main_file_link:
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url: https://doi.org/10.48550/arXiv.2410.12644
mathsc:
- 37D50
- 53C24
- 58J53
month: '07'
oa: 1
oa_version: Preprint
page: 469-488
publication: Journal of Modern Dynamics
publication_identifier:
eissn:
- 1930-532X
issn:
- 1930-5311
publication_status: published
publisher: American Institute of Mathematical Sciences
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Area spectral rigidity for axially symmetric symplectic billiard tables
type: journal_article
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volume: 22
year: '2026'
...
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article_processing_charge: No
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full_name: Tong, Xin
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last_name: Tong
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ama: Tong X. Towards a deeper understanding of meroblastic cleavage - supplementary
movies. 2026. doi:10.15479/AT-ISTA-22777
apa: Tong, X. (2026). Towards a deeper understanding of meroblastic cleavage - supplementary
movies. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-22777
chicago: Tong, Xin. “Towards a Deeper Understanding of Meroblastic Cleavage - Supplementary
Movies.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-22777.
ieee: X. Tong, “Towards a deeper understanding of meroblastic cleavage - supplementary
movies.” Institute of Science and Technology Austria, 2026.
ista: Tong X. 2026. Towards a deeper understanding of meroblastic cleavage - supplementary
movies, Institute of Science and Technology Austria, 10.15479/AT-ISTA-22777.
mla: Tong, Xin. Towards a Deeper Understanding of Meroblastic Cleavage - Supplementary
Movies. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-22777.
short: X. Tong, (2026).
corr_author: '1'
date_created: 2026-09-03T10:48:15Z
date_published: 2026-09-04T00:00:00Z
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month: '9'
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abstract:
- lang: eng
text: Tissue regeneration requires de novo patterning, which has been proposed to
be facilitated by cellular heterogeneity. Yet how such heterogeneities are integrated
with the mechanochemical state of the tissue and stabilized at the chromatin level
into stable, spatially organized fates remains poorly understood. Using in vivo
mouse intestinal regeneration models and organoids, we identify a critical density
regime that produces a permissive window for heterogeneity in the mechanosensor
Yes-associated protein 1 (YAP1). We show that YAP1 heterogeneity is coupled to
lineage-biased chromatin accessibility and is decoded through FOXA1, which integrates
the permissive chromatin state to Delta-Notch supracellular feedback and lineage
commitment. This circuit generates fate bistability and preserves a memory of
transient YAP1 activity, thereby maintaining spatial patterning as tissues return
to homeostasis after injury. Together, our findings establish a multiscale framework
in which tissue-scale mechanics tune single-cell competence and, through FOXA1-mediated
bistability, convert transient heterogeneity into stable and self-organized tissue
architecture.
acknowledgement: We thank the Liberali group, M. Verbeek, and C. Soneson for fruitful
discussions; E. Tagliavini for IT support; J. Lüthi for Fractal support; H. Köhler
for FACS sorting; T.O. Buchholz for help on cell segmentation; B. Treutlein and
A. Xavier da Silveira dos Santos for help with library preparation of single-cell
ATAC-seq; M. Garioni for help with mouse salivary organoids; M. Kahnwald for help
with human intestinal organoids; M. Lütolf, M. Nikolaev, and O. Mitrofanova for
providing material and initial training for microwell experiments; J. Tchorz and
V. Orsini for intestinal tissue sections of the YAP1 activator experiment in homeostasis;
R. Kageyama for DLL1-Venus-T2A-mCherry mice; J.-F. Spetz for technical assistance;
C. Lambert and N. Accart for help with sample preparation; Claudia Flandoli for
graphic design of schemes; and Zuzana Nascakova for the graphical abstract. We thank
the Foundation Hubrecht Organoid Technology (now Foundation Hubrecht Organoid Biobank,
https://www.hubrechtorganoidbiobank.org/) for the duodenal organoid line used in
this study (HUB-04-A2-001). We thank C.P. Heisenberg, M. Lütolf, C. Tsiairis, J.
Zaugg, G. D’Angelo, L. Giorgetti, S. Arber, and the Liberali group for reading the
manuscript. C.S. was supported by the European Molecular Biology Organization (Postdoctoral
Fellowship ALTF 660-2020) and the Human Frontier Science Program (HFSP) LT000746/2021-L.
D.B.B. was supported by the NOMIS Foundation as a NOMIS fellow, an EMBO Postdoctoral
Fellowship (ALTF 343-2022), and the Austrian Academy of Sciences through an APART-MINT
Fellowship. B.S. was supported by the Francis Crick Institute, which receives its
core funding from Cancer Research UK, the UK Medical Research Council, and the Wellcome
Trust (FC001159). This work received funding from ERC to E.H. (grant number 851288)
and to P.L. (grant number 758617) and from SNSF (310030_208162 and SNSF ERC TMCG-3_223263).
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Cornelia
full_name: Schwayer, Cornelia
id: 3436488C-F248-11E8-B48F-1D18A9856A87
last_name: Schwayer
orcid: 0000-0001-5130-2226
- first_name: Silvia
full_name: Barbiero, Silvia
last_name: Barbiero
- first_name: David
full_name: Brückner, David
id: e1e86031-6537-11eb-953a-f7ab92be508d
last_name: Brückner
orcid: 0000-0001-7205-2975
- first_name: Koen C.
full_name: Oost, Koen C.
last_name: Oost
- first_name: Clara
full_name: Baader, Clara
last_name: Baader
- first_name: Nicole A.
full_name: Repina, Nicole A.
last_name: Repina
- first_name: Jinse
full_name: Kim, Jinse
last_name: Kim
- first_name: Oscar E.
full_name: Diaz, Oscar E.
last_name: Diaz
- first_name: Isa
full_name: Uccelli, Isa
last_name: Uccelli
- first_name: Laura
full_name: Capolupo, Laura
last_name: Capolupo
- first_name: Ludivine Challet
full_name: Meylan, Ludivine Challet
last_name: Meylan
- first_name: Veronique
full_name: Kalck, Veronique
last_name: Kalck
- first_name: Franziska
full_name: Moos, Franziska
last_name: Moos
- first_name: Simon
full_name: Suppinger, Simon
last_name: Suppinger
- first_name: Qiutan
full_name: Yang, Qiutan
last_name: Yang
- first_name: Jakob
full_name: Schnabl, Jakob
last_name: Schnabl
- first_name: Umut
full_name: Kilik, Umut
last_name: Kilik
- first_name: Matthieu
full_name: Bourdon, Matthieu
last_name: Bourdon
- first_name: J. Gray
full_name: Camp, J. Gray
last_name: Camp
- first_name: Brigitta
full_name: Stockinger, Brigitta
last_name: Stockinger
- first_name: Alessandra
full_name: Ferrari, Alessandra
last_name: Ferrari
- first_name: Marc
full_name: Bühler, Marc
last_name: Bühler
- first_name: Michael B.
full_name: Stadler, Michael B.
last_name: Stadler
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Prisca
full_name: Liberali, Prisca
last_name: Liberali
citation:
ama: Schwayer C, Barbiero S, Brückner D, et al. Multiscale integration of tissue
and chromatin context converts cell heterogeneity into stable intestinal patterning.
Cell. 2026;189(17):5266-5282.e17. doi:10.1016/j.cell.2026.06.009
apa: Schwayer, C., Barbiero, S., Brückner, D., Oost, K. C., Baader, C., Repina,
N. A., … Liberali, P. (2026). Multiscale integration of tissue and chromatin context
converts cell heterogeneity into stable intestinal patterning. Cell. Cell
Press. https://doi.org/10.1016/j.cell.2026.06.009
chicago: Schwayer, Cornelia, Silvia Barbiero, David Brückner, Koen C. Oost, Clara
Baader, Nicole A. Repina, Jinse Kim, et al. “Multiscale Integration of Tissue
and Chromatin Context Converts Cell Heterogeneity into Stable Intestinal Patterning.”
Cell. Cell Press, 2026. https://doi.org/10.1016/j.cell.2026.06.009.
ieee: C. Schwayer et al., “Multiscale integration of tissue and chromatin
context converts cell heterogeneity into stable intestinal patterning,” Cell,
vol. 189, no. 17. Cell Press, p. 5266–5282.e17, 2026.
ista: Schwayer C, Barbiero S, Brückner D, Oost KC, Baader C, Repina NA, Kim J, Diaz
OE, Uccelli I, Capolupo L, Meylan LC, Kalck V, Moos F, Suppinger S, Yang Q, Schnabl
J, Kilik U, Bourdon M, Camp JG, Stockinger B, Ferrari A, Bühler M, Stadler MB,
Hannezo EB, Liberali P. 2026. Multiscale integration of tissue and chromatin context
converts cell heterogeneity into stable intestinal patterning. Cell. 189(17),
5266–5282.e17.
mla: Schwayer, Cornelia, et al. “Multiscale Integration of Tissue and Chromatin
Context Converts Cell Heterogeneity into Stable Intestinal Patterning.” Cell,
vol. 189, no. 17, Cell Press, 2026, p. 5266–5282.e17, doi:10.1016/j.cell.2026.06.009.
short: C. Schwayer, S. Barbiero, D. Brückner, K.C. Oost, C. Baader, N.A. Repina,
J. Kim, O.E. Diaz, I. Uccelli, L. Capolupo, L.C. Meylan, V. Kalck, F. Moos, S.
Suppinger, Q. Yang, J. Schnabl, U. Kilik, M. Bourdon, J.G. Camp, B. Stockinger,
A. Ferrari, M. Bühler, M.B. Stadler, E.B. Hannezo, P. Liberali, Cell 189 (2026)
5266–5282.e17.
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: "All sequencing data have been deposited at the Gene Expression
Omnibus (GEO) under accession number GEO: GSE283662.\r\nAnalysis of imaging and
sequencing data was developed in the Liberali lab and is available at https://github.com/LiberaliLab/symmetry-breaking-2026.
Detailed information on the packages used is provided in the STAR Methods section.\r\nAny
additional information required to reanalyze the data reported in this paper is
available from the lead contact upon request."
date_created: 2026-09-17T11:06:12Z
date_published: 2026-08-20T00:00:00Z
date_updated: 2026-10-01T08:42:00Z
day: '20'
ddc:
- '570'
doi: 10.1016/j.cell.2026.06.009
ec_funded: 1
external_id:
pmid:
- '42379166'
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date_created: 2026-10-01T08:34:11Z
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fulldoi: https://doi.org/10.1016/j.cell.2026.06.009
has_accepted_license: '1'
intvolume: ' 189'
issue: '17'
keyword:
- tissue patterning
- heterogeneity
- mechanics
- intestinal regeneration
- epigenetic competence
- multiscale integration
- modeling
- organoids
- image-based phenotyping
- Yap1
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 5266-5282.e17
pmid: 1
project:
- _id: 34e2a5b5-11ca-11ed-8bc3-b2265616ef0b
grant_number: ALTF 343-2022
name: A mechano-chemical theory for stem cell fate decisions in organoid development
- _id: 05943252-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '851288'
name: Design Principles of Branching Morphogenesis
publication: Cell
publication_identifier:
eissn:
- 1097-4172
issn:
- 0092-8674
publication_status: published
publisher: Cell Press
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Multiscale integration of tissue and chromatin context converts cell heterogeneity
into stable intestinal patterning
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 189
year: '2026'
...