---
OA_place: publisher
OA_type: hybrid
_id: '21759'
abstract:
- lang: eng
text: 'Promoters and enhancers are cis-regulatory elements (CREs), DNA sequences
that bind transcription factor (TF) proteins to up- or down-regulate target genes.
Decades-long efforts yielded TF-DNA interaction models that predict how strongly
an individual TF binds arbitrary DNA sequences and how individual binding events
on the CRE combine to affect gene expression. These insights can be synthesized
into a global, biophysically realistic, and quantitative genotype-phenotype (GP)
map for gene regulation, a ‘holy grail’ for the application of evolutionary theory.
A global map provides a rare opportunity to simulate the long-term evolution of
regulatory sequences and pose several fundamental questions: How long does it
take to evolve CREs de novo? How many non-trivial regulatory functions exist in
sequence space? How connected are they? For which regulatory architecture is CRE
evolution most rapid and evolvable? In this article, the second of a two-part
series, we review the application of evolutionary concepts — epistasis, robustness,
evolvability, tunability, plasticity, and bet-hedging — to the evolution of gene
regulatory sequences. We then evaluate the potential for a unifying theory for
the evolution of regulatory sequences and identify key open challenges.'
acknowledgement: "We thank Calin Guet and Santiago Herrera-Álvarez for essential contributions
to this manuscript.\r\nE.M. acknowledges support from the APART-USA fellowship,
jointly funded by the Austrian Academy of Sciences (ÖAW) and the Institute of Science
and Technology Austria (ISTA). N.B. acknowledges funding from the ERC Advanced Grant
101055327 “HaplotypeStructure”.\r\nThis study was also supported by the European
Molecular Biology Laboratory (N.O.B., J.C.)."
article_number: '102472'
article_processing_charge: Yes (via OA deal)
article_type: review
author:
- first_name: Elia
full_name: Mascolo, Elia
id: 776a6ed0-a053-11f0-8635-80b95e0e0d53
last_name: Mascolo
orcid: 0000-0003-2977-7844
- first_name: Reka E
full_name: Körei, Reka E
id: 50FDE43E-AA30-11E9-A72B-8A12E6697425
last_name: Körei
- first_name: Noa O.
full_name: Borst, Noa O.
last_name: Borst
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Justin
full_name: Crocker, Justin
last_name: Crocker
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
citation:
ama: 'Mascolo E, Körei RE, Borst NO, Barton NH, Crocker J, Tkačik G. Long-term evolution
of regulatory DNA sequences. Part 2: Theory and future challenges. Current
Opinion in Genetics and Development. 2026;98. doi:10.1016/j.gde.2026.102472'
apa: 'Mascolo, E., Körei, R. E., Borst, N. O., Barton, N. H., Crocker, J., &
Tkačik, G. (2026). Long-term evolution of regulatory DNA sequences. Part 2: Theory
and future challenges. Current Opinion in Genetics and Development. Elsevier.
https://doi.org/10.1016/j.gde.2026.102472'
chicago: 'Mascolo, Elia, Reka E Körei, Noa O. Borst, Nicholas H Barton, Justin Crocker,
and Gašper Tkačik. “Long-Term Evolution of Regulatory DNA Sequences. Part 2: Theory
and Future Challenges.” Current Opinion in Genetics and Development. Elsevier,
2026. https://doi.org/10.1016/j.gde.2026.102472.'
ieee: 'E. Mascolo, R. E. Körei, N. O. Borst, N. H. Barton, J. Crocker, and G. Tkačik,
“Long-term evolution of regulatory DNA sequences. Part 2: Theory and future challenges,”
Current Opinion in Genetics and Development, vol. 98. Elsevier, 2026.'
ista: 'Mascolo E, Körei RE, Borst NO, Barton NH, Crocker J, Tkačik G. 2026. Long-term
evolution of regulatory DNA sequences. Part 2: Theory and future challenges. Current
Opinion in Genetics and Development. 98, 102472.'
mla: 'Mascolo, Elia, et al. “Long-Term Evolution of Regulatory DNA Sequences. Part
2: Theory and Future Challenges.” Current Opinion in Genetics and Development,
vol. 98, 102472, Elsevier, 2026, doi:10.1016/j.gde.2026.102472.'
short: E. Mascolo, R.E. Körei, N.O. Borst, N.H. Barton, J. Crocker, G. Tkačik, Current
Opinion in Genetics and Development 98 (2026).
corr_author: '1'
date_created: 2026-04-26T22:01:46Z
date_published: 2026-04-15T00:00:00Z
date_updated: 2026-06-18T08:34:09Z
day: '15'
ddc:
- '570'
department:
- _id: GaTk
- _id: NiBa
doi: 10.1016/j.gde.2026.102472
intvolume: ' 98'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.gde.2026.102472
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: bd6958e0-d553-11ed-ba76-86eba6a76c00
grant_number: '101055327'
name: Understanding the evolution of continuous genomes
publication: Current Opinion in Genetics and Development
publication_identifier:
eissn:
- 1879-0380
issn:
- 0959-437X
publication_status: epub_ahead
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Long-term evolution of regulatory DNA sequences. Part 2: Theory and future
challenges'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 98
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21760'
abstract:
- lang: eng
text: 3I/ATLAS is the third interstellar object discovered to date, following 1I/‘Oumuamua
and 2I/Borisov. Its unusually high excess velocity and active cometary nature
make it a key probe of the Galactic population of icy planetesimals. Understanding
its origin requires its past trajectory through the Galaxy to be traced and the
possible role of stellar encounters to be assessed, both as a potential origin
and a perturber to its orbit. We integrated the orbit of 3I/ATLAS backward in
time for 10 Myr, together with a sample of Gaia DR3 stars with high-quality astrometry
and radial velocities, to identify close passages within 2 pc. We identify 93
nominal encounters, 62 of which are significant at the 2σ level. However, none
of these encounters produced any meaningful perturbation. The strongest perturber
Gaia DR3 6863591389529611264 at 0.30 pc and with a relative velocity of 35 km
s−1, imparted only a velocity change of ∣Δv∣ ≃ 5 × 10−4 km s−1 to the orbit
of 3I/ATLAS. Our results indicate that no stellar flybys within the past 10 Myr
and 500 pc contained in Gaia DR3 can account for the present trajectory of 3I/ATLAS
or be associated with its origin. We further show that 3I/ATLAS is kinematically
consistent with a thin-disk population, despite its large peculiar velocity.
acknowledgement: We thank the anonymous referee for a careful reading of the manuscript
and for constructive comments that improved the paper. X.P.C. and S.T. thank J.L.
Gragera-Más and Ylva Götberg for their valuable feedback and comments. X.P.C. acknowledges
financial support from the Spanish National Programme for the Promotion of Talent
and its Employability grant PRE2022-104959 cofunded by the European Social Fund.
S.T. acknowledges the funding from the European Union’s Horizon 2020 research and
innovation program under the Marie Skłodowska-Curie grant agreement No. 101034413.
E.V. acknowledges support from the DISCOBOLO project funded by the Spanish Ministerio
de Ciencia, Innovación y Universidades under grant PID2021-127289NB-I00. A.J.M.
acknowledges support from the Swedish National Space Agency (Career grant 2023-00146).
X.P.C. and M.M. acknowledge support from the Spanish Ministerio de Ciencia, Innovaciòn
y Universidades under grants PID2021122842OB-C22 and PID2024-157964OB-C22; from
the Xunta de Galicia and the European Union (FEDER Galicia 2021-2027 Program) Ref.
ED431B 2024/21, ED431B 2024/02, and CITIC ED431G 2023/01. This work has made use
of data from the European Space Agency (ESA) Gaia mission and processed by the Gaia
Data Processing and Analysis Consortium (DPAC). Funding for the DPAC has been provided
by national institutions, particularly the institutions participating in the Gaia
Multilateral Agreement.
article_number: '146'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: X.
full_name: Pérez-Couto, X.
last_name: Pérez-Couto
- first_name: Santiago
full_name: Torres Rodriguez, Santiago
id: a8df4360-4328-11ee-8f1a-e502d0c83fc2
last_name: Torres Rodriguez
orcid: 0000-0002-3150-8988
- first_name: E.
full_name: Villaver, E.
last_name: Villaver
- first_name: A. J.
full_name: Mustill, A. J.
last_name: Mustill
- first_name: M.
full_name: Manteiga, M.
last_name: Manteiga
citation:
ama: 'Pérez-Couto X, Torres Rodriguez S, Villaver E, Mustill AJ, Manteiga M. 3I/ATLAS:
In search of the witnesses to its voyage. The Astrophysical Journal. 2026;1001(2).
doi:10.3847/1538-4357/ae56ff'
apa: 'Pérez-Couto, X., Torres Rodriguez, S., Villaver, E., Mustill, A. J., &
Manteiga, M. (2026). 3I/ATLAS: In search of the witnesses to its voyage. The
Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ae56ff'
chicago: 'Pérez-Couto, X., Santiago Torres Rodriguez, E. Villaver, A. J. Mustill,
and M. Manteiga. “3I/ATLAS: In Search of the Witnesses to Its Voyage.” The
Astrophysical Journal. IOP Publishing, 2026. https://doi.org/10.3847/1538-4357/ae56ff.'
ieee: 'X. Pérez-Couto, S. Torres Rodriguez, E. Villaver, A. J. Mustill, and M. Manteiga,
“3I/ATLAS: In search of the witnesses to its voyage,” The Astrophysical Journal,
vol. 1001, no. 2. IOP Publishing, 2026.'
ista: 'Pérez-Couto X, Torres Rodriguez S, Villaver E, Mustill AJ, Manteiga M. 2026.
3I/ATLAS: In search of the witnesses to its voyage. The Astrophysical Journal.
1001(2), 146.'
mla: 'Pérez-Couto, X., et al. “3I/ATLAS: In Search of the Witnesses to Its Voyage.”
The Astrophysical Journal, vol. 1001, no. 2, 146, IOP Publishing, 2026,
doi:10.3847/1538-4357/ae56ff.'
short: X. Pérez-Couto, S. Torres Rodriguez, E. Villaver, A.J. Mustill, M. Manteiga,
The Astrophysical Journal 1001 (2026).
date_created: 2026-04-26T22:01:46Z
date_published: 2026-04-20T00:00:00Z
date_updated: 2026-04-28T13:08:39Z
day: '20'
ddc:
- '520'
department:
- _id: LiBu
doi: 10.3847/1538-4357/ae56ff
ec_funded: 1
external_id:
arxiv:
- '2509.07678'
file:
- access_level: open_access
checksum: c3daf49261a9933c079854c38eec316f
content_type: application/pdf
creator: dernst
date_created: 2026-04-28T13:06:00Z
date_updated: 2026-04-28T13:06:00Z
file_id: '21773'
file_name: 2026_AstrophysicalJournal_PerezCouto.pdf
file_size: 2905627
relation: main_file
success: 1
file_date_updated: 2026-04-28T13:06:00Z
has_accepted_license: '1'
intvolume: ' 1001'
issue: '2'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: '3I/ATLAS: In search of the witnesses to its voyage'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1001
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21761'
abstract:
- lang: eng
text: Neural tube closure is a critical morphogenetic process in vertebrate development,
and failure to close cranial regions such as the hindbrain neuropore (HNP) leads
to severe congenital malformations. While mechanical forces such as actomyosin
purse-string contraction and directional cell crawling have been implicated in
driving HNP closure, how these forces organize local cell shape and motion to
produce large-scale tissue remodeling remains poorly understood. Using live and
fixed imaging of mouse embryos combined with cell-based biophysical modeling,
we show that these force-generating mechanisms are insufficient to explain the
reproducible patterns of cell elongation and nematic alignment observed at the
HNP border. Instead, we show that local anisotropic stress and cytoskeletal organization
are required to generate these patterns and promote midline cell motion. Our model
captures key features of cell shape dynamics and emergent nematic order, which
we confirm experimentally, including the alignment of actin fibers with cell shape
and enhanced midline cell speed. Comparative analysis with chick embryos, which
lack supracellular purse strings, supports a conserved link between tension generation
and cellular patterning. These findings establish a physical framework connecting
force generation, cell shape anisotropy, and tissue morphodynamics during epithelial
gap closure.
acknowledgement: S.B. acknowledges support from the National Institutes of Health
(NIH R35 GM143042) and the National Science Foundation (NSF MCB-2203601). G.L.G.
acknowledges support from the Wellcome Trust (211112/Z/18/Z), the Royal Society
(RG\R2\232082), and the Leverhulme Trust (RPG-2024-147). E.M. acknowledges support
from European Union’s Horizon 2021 Marie Sklodowska-Curie grant agreement no. 101067028.
F.P.-V. acknowledges support from the NOMIS foundation. The surface subtraction
macro is courtesy of Dr. Dale Moulding and available on GitHub (https://github.com/DaleMoulding/Fiji-Macros).
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Fernanda L
full_name: Perez Verdugo, Fernanda L
id: 4ecec223-9070-11ef-a0a9-bc76077bea8d
last_name: Perez Verdugo
- first_name: Eirini
full_name: Maniou, Eirini
last_name: Maniou
- first_name: Gabriel L.
full_name: Galea, Gabriel L.
last_name: Galea
- first_name: Shiladitya
full_name: Banerjee, Shiladitya
last_name: Banerjee
citation:
ama: Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. Mechanosensitive feedback
organizes cell shape and motion during hindbrain neuropore morphogenesis. Current
Biology. 2026;36(8):1903-1917.e5. doi:10.1016/j.cub.2026.02.068
apa: Perez Verdugo, F. L., Maniou, E., Galea, G. L., & Banerjee, S. (2026).
Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore
morphogenesis. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2026.02.068
chicago: Perez Verdugo, Fernanda L, Eirini Maniou, Gabriel L. Galea, and Shiladitya
Banerjee. “Mechanosensitive Feedback Organizes Cell Shape and Motion during Hindbrain
Neuropore Morphogenesis.” Current Biology. Elsevier, 2026. https://doi.org/10.1016/j.cub.2026.02.068.
ieee: F. L. Perez Verdugo, E. Maniou, G. L. Galea, and S. Banerjee, “Mechanosensitive
feedback organizes cell shape and motion during hindbrain neuropore morphogenesis,”
Current Biology, vol. 36, no. 8. Elsevier, p. 1903–1917.e5, 2026.
ista: Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. 2026. Mechanosensitive feedback
organizes cell shape and motion during hindbrain neuropore morphogenesis. Current
Biology. 36(8), 1903–1917.e5.
mla: Perez Verdugo, Fernanda L., et al. “Mechanosensitive Feedback Organizes Cell
Shape and Motion during Hindbrain Neuropore Morphogenesis.” Current Biology,
vol. 36, no. 8, Elsevier, 2026, p. 1903–1917.e5, doi:10.1016/j.cub.2026.02.068.
short: F.L. Perez Verdugo, E. Maniou, G.L. Galea, S. Banerjee, Current Biology 36
(2026) 1903–1917.e5.
date_created: 2026-04-26T22:01:46Z
date_published: 2026-04-20T00:00:00Z
date_updated: 2026-04-28T13:15:42Z
day: '20'
ddc:
- '570'
department:
- _id: AnSa
doi: 10.1016/j.cub.2026.02.068
external_id:
pmid:
- '41881011'
file:
- access_level: open_access
checksum: 80ae45457b4682c50c84f54de15aa9a8
content_type: application/pdf
creator: dernst
date_created: 2026-04-28T13:13:40Z
date_updated: 2026-04-28T13:13:40Z
file_id: '21774'
file_name: 2026_CurrentBiology_PerezVerdugo.pdf
file_size: 13402043
relation: main_file
success: 1
file_date_updated: 2026-04-28T13:13:40Z
has_accepted_license: '1'
intvolume: ' 36'
issue: '8'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 1903-1917.e5
pmid: 1
publication: Current Biology
publication_identifier:
eissn:
- 1879-0445
issn:
- 0960-9822
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanosensitive feedback organizes cell shape and motion during hindbrain
neuropore morphogenesis
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 36
year: '2026'
...
---
OA_type: closed access
_id: '21762'
abstract:
- lang: eng
text: Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular
organization. The plasmid-encoded ParMRC system forms actin-like filaments that
segregate low–copy number plasmids. In multicellular cyanobacteria such as Anabaena
sp., we found that a chromosomally encoded ParMR system has evolved into a cytoskeletal
system named CorMR with a function in cell shape control rather than DNA segregation.
Live-cell imaging, in vitro reconstitution, and cryo–electron microscopy revealed
that CorM formed dynamically unstable, antiparallel double-stranded filaments
that were recruited to the membrane by CorR through an amphipathic helix conserved
in multicellular cyanobacteria. CorMR filaments were regulated by MinC, which
excluded them from the poles and division plane. Comparative genomics indicated
that the repurposing of ParMR and Min systems coevolved with cyanobacterial multicellularity,
highlighting the evolutionary plasticity of cytoskeletal systems in bacteria.
acknowledged_ssus:
- _id: Bio
- _id: ScienComp
- _id: EM-Fac
- _id: LifeSc
acknowledgement: "We thank all members of the Loose lab at ISTA for helpful discussions;
M. Kojic for critical reading of the manuscript; A. Herrero (Sevilla University)
for sharing her extensive BACTH plasmid library and other plasmids, as well as cyanobacterial
strains; T. Dagan and F. Nies (both Kiel University) for sharing cyanobacterial
strains and plasmids and for valuable discussions; N. Sapay and A. Michon for providing
the Amphipaseek code, which enabled us to perform our large-scale amphipathic helix
screen of cyanobacterial CorR proteins; V.-V. Hodirnau for support in cryo-ET data
collection; and J. Hansen for advice about cryo-EM data processing.\r\nThis work
was supported by the Scientific Service Units (SSU) of ISTA through resources provided
by the Imaging & Optics Facility (IOF), the Scientific Computing (SciComp), the
Electron Microscopy Facility (EMF), and the Lab Support Facility (LSF). This work
was funded by the European Union’s Horizon 2020 research and innovation program
(Marie Skłodowska-Curie grant 101034413 to B.L.S.); the European Research Council
(ERC) of the European Union (grant ActinID 101076260 to F.K.M.S.); the Swiss National
Science Foundation (starting grant TMSGI3_226208 to G.L.W.); and the Jean-Jacques
et Letitia Lopez-Loreta Foundation (G.L.W.)."
article_number: eaea6343
article_processing_charge: No
article_type: original
author:
- first_name: Benjamin L
full_name: Springstein, Benjamin L
id: b4eb62ef-ac72-11ed-9503-ed3b4d66c083
last_name: Springstein
orcid: 0000-0002-3461-5391
- first_name: Manjunath
full_name: Javoor, Manjunath
id: 305ab18b-dc7d-11ea-9b2f-b58195228ea2
last_name: Javoor
orcid: 0000-0003-2311-2112
- first_name: Daniela
full_name: Megrian, Daniela
last_name: Megrian
- first_name: Roman
full_name: Hajdu, Roman
id: ffab949d-133f-11ed-8f02-94de21ace503
last_name: Hajdu
- first_name: Dustin M.
full_name: Hanke, Dustin M.
last_name: Hanke
- first_name: Bettina
full_name: Zens, Bettina
id: 45FD126C-F248-11E8-B48F-1D18A9856A87
last_name: Zens
orcid: 0000-0002-9561-1239
- first_name: Gregor L.
full_name: Weiss, Gregor L.
last_name: Weiss
- first_name: Florian Km
full_name: Schur, Florian Km
id: 48AD8942-F248-11E8-B48F-1D18A9856A87
last_name: Schur
orcid: 0000-0003-4790-8078
- first_name: Martin
full_name: Loose, Martin
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
citation:
ama: Springstein BL, Javoor M, Megrian D, et al. Repurposing of a DNA segregation
machinery into a cytoskeletal system controlling cell shape. Science. 2026;392(6795).
doi:10.1126/science.aea6343
apa: Springstein, B. L., Javoor, M., Megrian, D., Hajdu, R., Hanke, D. M., Zens,
B., … Loose, M. (2026). Repurposing of a DNA segregation machinery into a cytoskeletal
system controlling cell shape. Science. AAAS. https://doi.org/10.1126/science.aea6343
chicago: Springstein, Benjamin L, Manjunath Javoor, Daniela Megrian, Roman Hajdu,
Dustin M. Hanke, Bettina Zens, Gregor L. Weiss, Florian KM Schur, and Martin Loose.
“Repurposing of a DNA Segregation Machinery into a Cytoskeletal System Controlling
Cell Shape.” Science. AAAS, 2026. https://doi.org/10.1126/science.aea6343.
ieee: B. L. Springstein et al., “Repurposing of a DNA segregation machinery
into a cytoskeletal system controlling cell shape,” Science, vol. 392,
no. 6795. AAAS, 2026.
ista: Springstein BL, Javoor M, Megrian D, Hajdu R, Hanke DM, Zens B, Weiss GL,
Schur FK, Loose M. 2026. Repurposing of a DNA segregation machinery into a cytoskeletal
system controlling cell shape. Science. 392(6795), eaea6343.
mla: Springstein, Benjamin L., et al. “Repurposing of a DNA Segregation Machinery
into a Cytoskeletal System Controlling Cell Shape.” Science, vol. 392,
no. 6795, eaea6343, AAAS, 2026, doi:10.1126/science.aea6343.
short: B.L. Springstein, M. Javoor, D. Megrian, R. Hajdu, D.M. Hanke, B. Zens, G.L.
Weiss, F.K. Schur, M. Loose, Science 392 (2026).
corr_author: '1'
date_created: 2026-04-26T22:01:46Z
date_published: 2026-04-16T00:00:00Z
date_updated: 2026-04-28T13:29:05Z
day: '16'
department:
- _id: MaLo
- _id: FlSc
- _id: GradSch
- _id: EM-Fac
doi: 10.1126/science.aea6343
ec_funded: 1
external_id:
pmid:
- '41990175'
intvolume: ' 392'
issue: '6795'
language:
- iso: eng
month: '04'
oa_version: None
pmid: 1
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
- _id: bd980d18-d553-11ed-ba76-ceaa645c97eb
grant_number: '101076260'
name: A molecular atlas of Actin filament IDentities in the cell motility machinery
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: Repurposing of a DNA segregation machinery into a cytoskeletal system controlling
cell shape
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 392
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21763'
abstract:
- lang: eng
text: Reactive oxygen species (ROS) have been implicated in multiple signaling processes
in plants, but the underlying mechanisms and roles remain enigmatic. In this study,
we developed a method of live imaging of apoplastic ROS at the root surface. Distinct
signals, including auxin, extracellular adenosine triphosphate, and rapid alkalinization
factor 1 peptide, induce cytosolic calcium transients and apoplastic ROS bursts.
Genetic and optogenetic manipulations of Arabidopsis identified calcium transients
as necessary and sufficient for ROS bursts through activation of reduced nicotinamide
adenine dinucleotide phosphate (NADPH) oxidases RBOHC and RBOHF. Apoplastic ROS
bursts are not required, but they do limit gravity-induced root bending. Root
bending is sensed by the stretch-activated calcium channel MCA1, leading to NADPH
oxidase activation. The resulting ROS production stiffens cell walls to facilitate
soil penetration. Apoplastic ROS thus provides a means to balance tissue flexibility
and stiffness to navigate soil.
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
acknowledgement: "We gratefully acknowledge the Lab Support Facility (LSF) and the
Imaging and Optics Facility (IOF) (both of ISTA) and the Hounsfield CT Facility
(University of Nottingham) for support with imaging and the Growth Facility (IPMB)
for plant cultivation. We thank M. Fendrych and his team for help with the microfluidics
upgrades and J. Atkinson at the University of Nottingham MakerSpace for 3D printing
of Arabidopsis mini-soil columns.\r\nThis project received funding from the European
Research Council (ERC; 101142681 CYNIPS) and the Austrian Science Fund (FWF; P 37051-B).
I.K. was cofunded by the European Union, Horizon Europe, project MOLIPEC, ID 101087030
and CSF project 25-16449S. L.V. and B.K.P. acknowledge funding from UK Research
and Innovation (UKRI) Frontiers Research (EP/Y036697/1). M.J.B. acknowledges funding
from ERC SYNERGY (grant 101118769 HYDROSENSING). The study was partially supported
by the Université Paris Cité, Idex ANR-18-IDEX-0001, funded by the French Government
through its “Investments for the Future” program and also by the projects “Mecha-Nuc”
ANR-20-CE13-0025-03 and “scEm-bryoMech” ANR-21-CE13-0046. P.D. acknowledges support
by Human Frontier Science Program Organization grant 2022-RG107. P.V. acknowledges
support provided by “Programme blanc” of the Graduate School BIOSPHERA, Université
Paris-Saclay. Phytohormonal analysis was performed using the service laboratory
funded by Toward Next GENeration Crops, reg. no. CZ.02.01.01/00/22_008/0004581 of
the European Regional Development Fund (ERDF) program Johannes Amos Comenius. This
research was funded in whole or in part by the Austrian Science Fund (P 37051-B)
and UK Research and Innovation (EP/Y036697/1), cOAlition S organizations, and by
the European Research Council (101142681 CYNIPS, 101118769 HYDROSENSING); as required,
the author will make the Author Accepted Manuscript (AAM) version available under
a CC BY public copyright license."
article_processing_charge: No
article_type: original
author:
- first_name: Ivan
full_name: Kulich, Ivan
id: 57a1567c-8314-11eb-9063-c9ddc3451a54
last_name: Kulich
- first_name: Dmitrii
full_name: Vladimirtsev, Dmitrii
id: 60466724-5355-11ee-ae5a-fa55e8f99c3d
last_name: Vladimirtsev
- first_name: Marek
full_name: Randuch, Marek
id: 6ac4636d-15b2-11ec-abd3-fb8df79972ae
last_name: Randuch
- first_name: Shiqiang
full_name: Gao, Shiqiang
last_name: Gao
- first_name: Matteo
full_name: Citterico, Matteo
last_name: Citterico
- first_name: Kai R.
full_name: Konrad, Kai R.
last_name: Konrad
- first_name: Georg
full_name: Nagel, Georg
last_name: Nagel
- first_name: Michael
full_name: Wrzaczek, Michael
last_name: Wrzaczek
- first_name: Léa
full_name: Cascaro, Léa
last_name: Cascaro
- first_name: Pauline
full_name: Vinet, Pauline
last_name: Vinet
- first_name: Pauline
full_name: Durand, Pauline
last_name: Durand
- first_name: Atef
full_name: Asnacios, Atef
last_name: Asnacios
- first_name: Lokesh
full_name: Verma, Lokesh
last_name: Verma
- first_name: Malcolm J.
full_name: Bennett, Malcolm J.
last_name: Bennett
- first_name: Bipin K.
full_name: Pandey, Bipin K.
last_name: Pandey
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Kulich I, Vladimirtsev D, Randuch M, et al. Calcium-triggered apoplastic ROS
bursts balance gravity and mechanical signals for soil navigation. Science.
2026;392(6795):296-300. doi:10.1126/science.adu8197
apa: Kulich, I., Vladimirtsev, D., Randuch, M., Gao, S., Citterico, M., Konrad,
K. R., … Friml, J. (2026). Calcium-triggered apoplastic ROS bursts balance gravity
and mechanical signals for soil navigation. Science. AAAS. https://doi.org/10.1126/science.adu8197
chicago: Kulich, Ivan, Dmitrii Vladimirtsev, Marek Randuch, Shiqiang Gao, Matteo
Citterico, Kai R. Konrad, Georg Nagel, et al. “Calcium-Triggered Apoplastic ROS
Bursts Balance Gravity and Mechanical Signals for Soil Navigation.” Science.
AAAS, 2026. https://doi.org/10.1126/science.adu8197.
ieee: I. Kulich et al., “Calcium-triggered apoplastic ROS bursts balance
gravity and mechanical signals for soil navigation,” Science, vol. 392,
no. 6795. AAAS, pp. 296–300, 2026.
ista: Kulich I, Vladimirtsev D, Randuch M, Gao S, Citterico M, Konrad KR, Nagel
G, Wrzaczek M, Cascaro L, Vinet P, Durand P, Asnacios A, Verma L, Bennett MJ,
Pandey BK, Friml J. 2026. Calcium-triggered apoplastic ROS bursts balance gravity
and mechanical signals for soil navigation. Science. 392(6795), 296–300.
mla: Kulich, Ivan, et al. “Calcium-Triggered Apoplastic ROS Bursts Balance Gravity
and Mechanical Signals for Soil Navigation.” Science, vol. 392, no. 6795,
AAAS, 2026, pp. 296–300, doi:10.1126/science.adu8197.
short: I. Kulich, D. Vladimirtsev, M. Randuch, S. Gao, M. Citterico, K.R. Konrad,
G. Nagel, M. Wrzaczek, L. Cascaro, P. Vinet, P. Durand, A. Asnacios, L. Verma,
M.J. Bennett, B.K. Pandey, J. Friml, Science 392 (2026) 296–300.
corr_author: '1'
date_created: 2026-04-26T22:01:47Z
date_published: 2026-04-16T00:00:00Z
date_updated: 2026-05-07T06:20:07Z
day: '16'
ddc:
- '580'
department:
- _id: JiFr
- _id: GradSch
doi: 10.1126/science.adu8197
external_id:
pmid:
- '41990180'
file:
- access_level: open_access
checksum: eb5b29247832ecdc53c8146da0509bbe
content_type: application/pdf
creator: dernst
date_created: 2026-05-07T05:54:43Z
date_updated: 2026-05-07T05:54:43Z
file_id: '21832'
file_name: 2026_Science_Kulich_accepted.pdf
file_size: 6150733
relation: main_file
success: 1
file_date_updated: 2026-05-07T05:54:43Z
has_accepted_license: '1'
intvolume: ' 392'
issue: '6795'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Accepted Version
page: 296-300
pmid: 1
project:
- _id: 8f347782-16d5-11f0-9cad-8c19706ee739
grant_number: '101142681'
name: Cyclic nucleotides as second messengers in plants
- _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6
grant_number: P37051
name: Guanylate cyclase activity of TIR1/AFBs auxin receptors
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals
for soil navigation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 392
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21764'
abstract:
- lang: eng
text: "Colloidal fluids can exhibit complex phase behavior and determining phase
diagrams via experiments or computer simulations can be laborious. We demonstrate
that the dispersion relation ω(k), obtained from dynamical density functional
theory for the uniform density system, is a highly versatile tool for predicting
where in the phase diagram complex crystals form. The sign of ω(k) determines
whether density modes with wave number k grow or decay over time. We demonstrate
the predictive power by investigating the complex phase behavior of particles
interacting via core-shoulder pair potentials. With complementary Monte Carlo
simulations, we show that regions of the phase diagram where ωðkÞ has one or several
unstable (growing) wave numbers are also where crystalline phases occur. Going
further, by tuning these\r\nunstable wave numbers via the interaction-potential
and state-point parameters, we design systems with quasicrystals in the phase
diagram. We identify a system with a certain shoulder range exhibiting at least
ten different phases. Our general approach accelerates considerably the mapping
of complex phase diagrams, crucial for the design of new materials."
acknowledgement: "The authors thank Ms. Katrin Muck for her guidance related to the
use of HPC. The MC\r\ncomputer simulation results presented here were enabled via
a generous share of CPU time, offered by the Vienna Scientific Cluster (VSC) under
Project No. 71263. A. J. A. gratefully acknowledges support from the EPSRC under
Grant No. EP/P015689/1. This research was funded in part by the Austrian Science
Fund (FWF) [Grant DOI: 10.55776/PIN8759524], gratefully acknowledged by G. K ."
article_number: '148203'
article_processing_charge: Yes (in subscription journal)
article_type: original
arxiv: 1
author:
- first_name: Michael
full_name: Wassermair, Michael
id: 23d132c4-4e98-11ef-b275-9e8d4cd8c917
last_name: Wassermair
orcid: 0009-0003-6339-4051
- first_name: Gerhard
full_name: Kahl, Gerhard
last_name: Kahl
- first_name: Roland
full_name: Roth, Roland
last_name: Roth
- first_name: Andrew J.
full_name: Archer, Andrew J.
last_name: Archer
citation:
ama: Wassermair M, Kahl G, Roth R, Archer AJ. Navigating complex phase diagrams
in soft matter systems. Physical Review Letters. 2026;136(14). doi:10.1103/nbvt-fgjy
apa: Wassermair, M., Kahl, G., Roth, R., & Archer, A. J. (2026). Navigating
complex phase diagrams in soft matter systems. Physical Review Letters.
American Physical Society. https://doi.org/10.1103/nbvt-fgjy
chicago: Wassermair, Michael, Gerhard Kahl, Roland Roth, and Andrew J. Archer. “Navigating
Complex Phase Diagrams in Soft Matter Systems.” Physical Review Letters.
American Physical Society, 2026. https://doi.org/10.1103/nbvt-fgjy.
ieee: M. Wassermair, G. Kahl, R. Roth, and A. J. Archer, “Navigating complex phase
diagrams in soft matter systems,” Physical Review Letters, vol. 136, no.
14. American Physical Society, 2026.
ista: Wassermair M, Kahl G, Roth R, Archer AJ. 2026. Navigating complex phase diagrams
in soft matter systems. Physical Review Letters. 136(14), 148203.
mla: Wassermair, Michael, et al. “Navigating Complex Phase Diagrams in Soft Matter
Systems.” Physical Review Letters, vol. 136, no. 14, 148203, American Physical
Society, 2026, doi:10.1103/nbvt-fgjy.
short: M. Wassermair, G. Kahl, R. Roth, A.J. Archer, Physical Review Letters 136
(2026).
date_created: 2026-04-26T22:01:47Z
date_published: 2026-04-10T00:00:00Z
date_updated: 2026-04-28T07:03:48Z
day: '10'
ddc:
- '530'
department:
- _id: AnSa
- _id: GradSch
doi: 10.1103/nbvt-fgjy
external_id:
arxiv:
- '2603.18918'
file:
- access_level: open_access
checksum: 8ffb139122a185fcddbe6a9c901a287c
content_type: application/pdf
creator: dernst
date_created: 2026-04-28T06:58:40Z
date_updated: 2026-04-28T06:58:40Z
file_id: '21769'
file_name: 2026_PhysicalReviewLetters_Wassermair.pdf
file_size: 4336488
relation: main_file
success: 1
file_date_updated: 2026-04-28T06:58:40Z
has_accepted_license: '1'
intvolume: ' 136'
issue: '14'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
publication: Physical Review Letters
publication_identifier:
eissn:
- 1079-7114
issn:
- 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Navigating complex phase diagrams in soft matter systems
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 136
year: '2026'
...
---
OA_type: closed access
_id: '21765'
abstract:
- lang: eng
text: "Dielectric particles of the same material exchange electrical charge during
collisions or sliding contacts, yet the underlying charge-exchange mechanism is
still not understood. The fact that particles can become highly charged as a result
of this effect has significant consequences for many settings, both in nature
and industry, such as thunderstorms, volcanic eruptions, particle aggregation
during meteorite and planet formation, and the clogging of industrial granular
systems. Toward understanding these systems, great efforts have been made to develop
precise in situ measurements for particle charge, e.g., to determine ensemble
charge distributions or measure exchange during individual contacts. Here, we
present experimental results concerning the particle size scaling of the stationary-state
charge distributions of oxide particles in the sub-millimeter range. We measure
the charge distributions for large ensembles of monodisperse ZrO2:SiO2 composite
spheres, ranging from 172 to 545µm in diameter. These distributions are non-Gaussian
and collapse to a single master curve when plotted as functions of the surface
charge density Σ=\U0001D45E/4\U0001D70B\U0001D4452. X-ray fluorescence and atomic
force microscopy measurements show that the differences in the measured charge
distributions are not due to variations in chemical composition or surface roughness,
but rather to size alone. Our findings provide constraints on microscopic models
for charge exchange, namely that they should lead to steady-state distributions
that are non-Gaussian and scale in a specific way with particle size."
acknowledgement: This research was supported by ANID Grants QUIMAL No. 160001, FONDECYT
No. 1221597, and FONDEQUIP No. EQM190177. The authors thank Rodrigo Espinoza for
the EDS-SEM measurements and Domingo Jullian for fruitful discussions. We also acknowledge
the technical assistance of Ricardo Silva and Andrés Espinosa at DFI, FCFM, Universidad
de Chile.
article_number: '045604'
article_processing_charge: No
article_type: original
author:
- first_name: Macarena
full_name: Lara, Macarena
last_name: Lara
- first_name: Marcos
full_name: Flores, Marcos
last_name: Flores
- first_name: Gustavo
full_name: Castillo, Gustavo
last_name: Castillo
- first_name: Santiago
full_name: Tassara, Santiago
last_name: Tassara
- first_name: Scott R
full_name: Waitukaitis, Scott R
id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87
last_name: Waitukaitis
orcid: 0000-0002-2299-3176
- first_name: Nicolás
full_name: Mujica, Nicolás
last_name: Mujica
citation:
ama: Lara M, Flores M, Castillo G, Tassara S, Waitukaitis SR, Mujica N. Particle
size scaling of non-Gaussian granular charge distributions. Physical Review
Materials. 2026;10(4). doi:10.1103/qw6t-xqdw
apa: Lara, M., Flores, M., Castillo, G., Tassara, S., Waitukaitis, S. R., &
Mujica, N. (2026). Particle size scaling of non-Gaussian granular charge distributions.
Physical Review Materials. American Physical Society. https://doi.org/10.1103/qw6t-xqdw
chicago: Lara, Macarena, Marcos Flores, Gustavo Castillo, Santiago Tassara, Scott
R Waitukaitis, and Nicolás Mujica. “Particle Size Scaling of Non-Gaussian Granular
Charge Distributions.” Physical Review Materials. American Physical Society,
2026. https://doi.org/10.1103/qw6t-xqdw.
ieee: M. Lara, M. Flores, G. Castillo, S. Tassara, S. R. Waitukaitis, and N. Mujica,
“Particle size scaling of non-Gaussian granular charge distributions,” Physical
Review Materials, vol. 10, no. 4. American Physical Society, 2026.
ista: Lara M, Flores M, Castillo G, Tassara S, Waitukaitis SR, Mujica N. 2026. Particle
size scaling of non-Gaussian granular charge distributions. Physical Review Materials.
10(4), 045604.
mla: Lara, Macarena, et al. “Particle Size Scaling of Non-Gaussian Granular Charge
Distributions.” Physical Review Materials, vol. 10, no. 4, 045604, American
Physical Society, 2026, doi:10.1103/qw6t-xqdw.
short: M. Lara, M. Flores, G. Castillo, S. Tassara, S.R. Waitukaitis, N. Mujica,
Physical Review Materials 10 (2026).
date_created: 2026-04-26T22:01:47Z
date_published: 2026-04-01T00:00:00Z
date_updated: 2026-04-28T07:13:56Z
day: '01'
department:
- _id: ScWa
doi: 10.1103/qw6t-xqdw
intvolume: ' 10'
issue: '4'
language:
- iso: eng
month: '04'
oa_version: None
publication: Physical Review Materials
publication_identifier:
eissn:
- 2475-9953
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Particle size scaling of non-Gaussian granular charge distributions
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21766'
abstract:
- lang: eng
text: We provide a new characterisation of the decades old open problem of extending
bilipschitz mappings given on a Euclidean separated net. In particular, this allows
for the complete positive solution of the open problem in dimension two. Along
the way, we develop a set of tools for bilipschitz extensions of mappings between
subsets of Euclidean spaces.
acknowledgement: "The present work developed from a research visit of M.D. to V.K.
at IST Austria, funded by\r\na London Mathematical Society Research in Pairs grant.
This work was done while V.K. was fully funded by the Austria Science Fund (FWF)
[M 3100-N]."
article_processing_charge: Yes (in subscription journal)
article_type: original
arxiv: 1
author:
- first_name: Michael
full_name: Dymond, Michael
last_name: Dymond
- first_name: Vojtech
full_name: Kaluza, Vojtech
id: 21AE5134-9EAC-11EA-BEA2-D7BD3DDC885E
last_name: Kaluza
orcid: 0000-0002-2512-8698
citation:
ama: Dymond M, Kaluza V. Extending bilipschitz mappings between separated nets.
Annales Fennici Mathematici. 2026;51(1):237-260. doi:10.54330/afm.181562
apa: Dymond, M., & Kaluza, V. (2026). Extending bilipschitz mappings between
separated nets. Annales Fennici Mathematici. Finnish Mathematical Society.
https://doi.org/10.54330/afm.181562
chicago: Dymond, Michael, and Vojtech Kaluza. “Extending Bilipschitz Mappings between
Separated Nets.” Annales Fennici Mathematici. Finnish Mathematical Society,
2026. https://doi.org/10.54330/afm.181562.
ieee: M. Dymond and V. Kaluza, “Extending bilipschitz mappings between separated
nets,” Annales Fennici Mathematici, vol. 51, no. 1. Finnish Mathematical
Society, pp. 237–260, 2026.
ista: Dymond M, Kaluza V. 2026. Extending bilipschitz mappings between separated
nets. Annales Fennici Mathematici. 51(1), 237–260.
mla: Dymond, Michael, and Vojtech Kaluza. “Extending Bilipschitz Mappings between
Separated Nets.” Annales Fennici Mathematici, vol. 51, no. 1, Finnish Mathematical
Society, 2026, pp. 237–60, doi:10.54330/afm.181562.
short: M. Dymond, V. Kaluza, Annales Fennici Mathematici 51 (2026) 237–260.
corr_author: '1'
date_created: 2026-04-26T22:01:47Z
date_published: 2026-04-17T00:00:00Z
date_updated: 2026-04-28T12:06:00Z
day: '17'
ddc:
- '510'
department:
- _id: UlWa
doi: 10.54330/afm.181562
external_id:
arxiv:
- '2507.22007'
file:
- access_level: open_access
checksum: 442023926a3803d5d6ca8db8dbc4af1c
content_type: application/pdf
creator: dernst
date_created: 2026-04-28T12:03:13Z
date_updated: 2026-04-28T12:03:13Z
file_id: '21772'
file_name: 2026_AnnalesFenniciMath_Dymond.pdf
file_size: 342082
relation: main_file
success: 1
file_date_updated: 2026-04-28T12:03:13Z
has_accepted_license: '1'
intvolume: ' 51'
issue: '1'
keyword:
- Lipschitz
- bilipschitz
- extension
- separated net.
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 237-260
project:
- _id: fc35eaa2-9c52-11eb-aca3-88501ab155e9
grant_number: M03100
name: Spectra and topology of graphs and of simplicial complexes
publication: Annales Fennici Mathematici
publication_identifier:
eissn:
- 2737-114X
issn:
- 2737-0690
publication_status: published
publisher: Finnish Mathematical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Extending bilipschitz mappings between separated nets
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 51
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21767'
abstract:
- lang: eng
text: 'The involvement of non-scientific staff in discussions about animal welfare
and scientific quality is essential for biomedical research progress. In this
study, we developed a survey to collect the self-perception of animal care staff
(ACS) and laboratory technicians about their involvement in scientific planning
and conduct. Participants were contacted to complete an anonymous online questionnaire.
We obtained 850 responses, mainly from Europe: 564 from ACS and 286 from laboratory
technicians. Job satisfaction was assessed as positive by ACS and laboratory technicians
despite the low frequency of culture of care activities and mental health meetings.
Both groups expressed their desire to be trained in research planning and conduct;
however, regular training was not reported. In addition, the inability to act
on animal welfare concerns owing to experimental reasons was reported by both
groups. Over half of the participants felt valued and appreciated by the lead
scientists or animal facility manager; however, it is not clear how they are acknowledged,
as their names on the authors list or in the manuscript acknowledgments are barely
included. Our results indicated that involvement of ACS and laboratory technicians
in planning and conducting studies would improve their understanding of how experiments
are done, and therefore communication processes, work satisfaction, animal welfare,
and scientific quality. Finally, we provided recommendations to improve the engagement
of ACS and laboratory technicians in discussions about animal research planning
and conduct.'
- lang: fre
text: 'La participation de personnel non-scientifique aux discussions sur le bien-être
animal et la qualité scientifique est essentielle aux progrès la recherche biomédicale.
Dans cette étude, nous avons développé une enquête pour recueillir l''auto-perception
du personnel chargé des soins prodigués aux animaux (PCSA) et des techniciens
de laboratoire (TL) sur leur implication dans la planification et la conduite
scientifiques. Les participants ont été contactés pour remplir un questionnaire
anonyme en ligne. Nous avons obtenu 850 réponses, principalement en Europe : 564
provenant de PCSA et 286 de TL. La satisfaction au travail a été évaluée comme
positive par le PCSA et les TL malgré la faible fréquence d’activités sur la culture
des soins et de réunions concernant la santé mentale. Bien que les deux groupes
aient exprimé leur désir d''être formés à la planification et à la conduite de
la recherche, aucune formation réelle régulière n''a été signalée. De plus, l''incapacité
d''agir sur les préoccupations relatives au bien-être animal pour des raisons
expérimentales a été signalée par les deux groupes. Plus de la moitié des participants
se sont sentis valorisés et appréciés par les scientifiques principaux ou le gestionnaire
de l’installation animale mais on ne sait pas clairement comment ils sont reconnus,
car leurs noms sur la liste des auteurs ou dans les remerciements sont à peine
inclus dans la documentation. Nos résultats ont indiqué que la participation du
PCSA et des TL à la planification et à la conduite des études améliorerait leur
compréhension de la façon dont les expériences sont effectuées et, par conséquent,
les processus de communication, leur satisfaction au travail ainsi que le bien-être
animal et la qualité scientifique. Enfin, nous avons formulé des recommandations
pour améliorer la participation du PCSA et des TL aux discussions sur la planification
et la conduite de la recherche animale.'
- lang: ger
text: 'Die Einbeziehung von nichtwissenschaftlichem Personal in Diskussionen über
Tierschutz und wissenschaftliche Qualität ist für Fortschritte in biomedizinischer
Forschung von entscheidender Bedeutung. In dieser Studie haben wir eine Umfrage
entwickelt, um die Selbsteinschätzung von Tierpflegern (ACS) und Labortechnikern
(LT) hinsichtlich ihrer Beteiligung an der wissenschaftlichen Planung und Durchführung
zu erfassen. Die Teilnehmer wurden gebeten, einen anonymen Online-Fragebogen auszufüllen.
Wir erhielten 850 Rückmeldungen, hauptsächlich aus Europa: 564 von ACS und 286
von LT. Die Arbeitszufriedenheit wurde von ACS und LT trotz der geringen Häufigkeit
von Pflegeaktivitäten und Treffen zum Thema psychische Gesundheit als positiv
bewertet. Beide Gruppen äußerten den Wunsch, in der Forschungsplanung und -durchführung
geschult zu werden, doch regelmäßig stattfindende Schulungen wurden nicht berichtet.
Außerdem wurde von beiden Gruppen vermeldet, dass sie aus versuchstechnischen
Gründen nicht in der Lage waren, auf Tierschutzbedenken zu reagieren. Über die
Hälfte der Teilnehmer fühlte sich von den leitenden Wissenschaftlern oder dem
Leiter der Tierhaltungseinrichtung geschätzt und anerkannt; es ist jedoch unklar,
inwiefern sie wirklich gewürdigt werden, da ihre Namen kaum in der Autorenliste
oder in den Danksagungen des Manuskripts aufgeführt sind. Unsere Ergebnisse deuteten
darauf hin, dass die Einbeziehung von ACS und LT in die Planung und Durchführung
von Studien ihr Verständnis für die Durchführung von Experimenten verbessern würde
– und damit auch Kommunikationsprozesse, Arbeitszufriedenheit, Tierwohl und wissenschaftliche
Qualität. Abschließend gaben wir Empfehlungen zur Verbesserung der Einbeziehung
von ACS und LT in Diskussionen über die Planung und Durchführung von Tierversuchen.'
- lang: spa
text: 'La participación del personal no científico en los debates sobre el bienestar
animal y la calidad científica es fundamental para el avance de la investigación
biomédica. En este estudio, desarrollamos una encuesta para recoger la autopercepción
del personal encargado del cuidado de los animales (ACS) y de los técnicos de
laboratorio (LT) sobre su implicación en la planificación y la realización científicas.
Se contactó con los participantes para que cumplimentaran un cuestionario anónimo
en línea. Obtuvimos 850 respuestas, principalmente de Europa: 564 de ACS y 286
de LT. La satisfacción laboral fue evaluada como positiva por ACS y técnicos de
laboratorio a pesar de la baja frecuencia de actividades de cultura del cuidado
y reuniones sobre bienestar mental. Ambos grupos expresaron su deseo de recibir
formación en planificación y realización de investigaciones, sin embargo, no se
informó sobre una formación regular. Asimismo, ambos grupos señalaron la incapacidad
de actuar ante las preocupaciones sobre el bienestar animal por motivos experimentales.
Más de la mitad de los participantes se sintieron valorados y apreciados por los
científicos principales o el responsable de las instalaciones de animales; sin
embargo, no está claro cómo se les reconoce, ya que apenas se incluyen sus nombres
en la lista de autores o en los agradecimientos del manuscrito. Nuestros resultados
indicaron que la participación de los ACS y los LT en la planificación y realización
de los estudios mejoraría su comprensión de cómo se hacen los experimentos y,
por tanto, los procesos de comunicación, la satisfacción laboral, el bienestar
animal y la calidad científica. Finalmente, proporcionamos recomendaciones para
mejorar el compromiso de la AEC y la LT en los debates sobre la planificación
y la realización de investigaciones con animales.'
acknowledgement: "We deeply acknowledge all the animal care staff and laboratory technicians
who participated in this study! We acknowledge Working Groups 1 and 4 from COST
Action IMPROVE (“3Rs concepts to improve the quality of biomedical science”), CA21139,
supported by COST (European Cooperation in Science and Technology) for their feedback
and support. We also acknowledge Aoife Milford for her comments and contributions
to the final draft of the manuscript.\r\nThis publication was based on work from
the COST Action IMPROVE (“3Rs concepts to improve the quality of biomedical science”),
CA21139, supported by COST (European Cooperation in Science and Technology)."
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Fernando
full_name: Gonzalez-Uarquin, Fernando
last_name: Gonzalez-Uarquin
- first_name: Paulin
full_name: Jirkof, Paulin
last_name: Jirkof
- first_name: Bettina
full_name: Bert, Bettina
last_name: Bert
- first_name: Penny
full_name: Hawkins, Penny
last_name: Hawkins
- first_name: Ljupco
full_name: Angelovski, Ljupco
last_name: Angelovski
- first_name: Jan
full_name: Baumgart, Jan
last_name: Baumgart
- first_name: Nadine
full_name: Baumgart, Nadine
last_name: Baumgart
- first_name: Özge S.
full_name: Cevik, Özge S.
last_name: Cevik
- first_name: Nuno H.
full_name: Franco, Nuno H.
last_name: Franco
- first_name: Erdal
full_name: Horata, Erdal
last_name: Horata
- first_name: Rohish
full_name: Kaura, Rohish
last_name: Kaura
- first_name: Winfried
full_name: Neuhaus, Winfried
last_name: Neuhaus
- first_name: Brigida
full_name: Riso, Brigida
last_name: Riso
- first_name: Adrian J.
full_name: Smith, Adrian J.
last_name: Smith
- first_name: Athanassia
full_name: Sotiropoulos, Athanassia
last_name: Sotiropoulos
- first_name: Augusto
full_name: Vitale, Augusto
last_name: Vitale
- first_name: Sophie
full_name: Schober, Sophie
id: 80b0a0ef-4b9f-11ec-b119-8d9d94c4a1d8
last_name: Schober
citation:
ama: 'Gonzalez-Uarquin F, Jirkof P, Bert B, et al. Building bridges: Involvement
of animal care staff and laboratory technicians in experimental planning and conduct
of animal studies for better job satisfaction and science. Laboratory Animals.
2026. doi:10.1177/00236772251400976'
apa: 'Gonzalez-Uarquin, F., Jirkof, P., Bert, B., Hawkins, P., Angelovski, L., Baumgart,
J., … Schober, S. (2026). Building bridges: Involvement of animal care staff and
laboratory technicians in experimental planning and conduct of animal studies
for better job satisfaction and science. Laboratory Animals. SAGE Publications.
https://doi.org/10.1177/00236772251400976'
chicago: 'Gonzalez-Uarquin, Fernando, Paulin Jirkof, Bettina Bert, Penny Hawkins,
Ljupco Angelovski, Jan Baumgart, Nadine Baumgart, et al. “Building Bridges: Involvement
of Animal Care Staff and Laboratory Technicians in Experimental Planning and Conduct
of Animal Studies for Better Job Satisfaction and Science.” Laboratory Animals.
SAGE Publications, 2026. https://doi.org/10.1177/00236772251400976.'
ieee: 'F. Gonzalez-Uarquin et al., “Building bridges: Involvement of animal
care staff and laboratory technicians in experimental planning and conduct of
animal studies for better job satisfaction and science,” Laboratory Animals.
SAGE Publications, 2026.'
ista: 'Gonzalez-Uarquin F, Jirkof P, Bert B, Hawkins P, Angelovski L, Baumgart J,
Baumgart N, Cevik ÖS, Franco NH, Horata E, Kaura R, Neuhaus W, Riso B, Smith AJ,
Sotiropoulos A, Vitale A, Schober S. 2026. Building bridges: Involvement of animal
care staff and laboratory technicians in experimental planning and conduct of
animal studies for better job satisfaction and science. Laboratory Animals.'
mla: 'Gonzalez-Uarquin, Fernando, et al. “Building Bridges: Involvement of Animal
Care Staff and Laboratory Technicians in Experimental Planning and Conduct of
Animal Studies for Better Job Satisfaction and Science.” Laboratory Animals,
SAGE Publications, 2026, doi:10.1177/00236772251400976.'
short: F. Gonzalez-Uarquin, P. Jirkof, B. Bert, P. Hawkins, L. Angelovski, J. Baumgart,
N. Baumgart, Ö.S. Cevik, N.H. Franco, E. Horata, R. Kaura, W. Neuhaus, B. Riso,
A.J. Smith, A. Sotiropoulos, A. Vitale, S. Schober, Laboratory Animals (2026).
date_created: 2026-04-26T22:01:47Z
date_published: 2026-04-14T00:00:00Z
date_updated: 2026-06-18T08:33:36Z
day: '14'
ddc:
- '570'
department:
- _id: PreCl
doi: 10.1177/00236772251400976
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1177/00236772251400976
month: '04'
oa: 1
oa_version: Published Version
publication: Laboratory Animals
publication_identifier:
eissn:
- 1758-1117
issn:
- 0023-6772
publication_status: epub_ahead
publisher: SAGE Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Building bridges: Involvement of animal care staff and laboratory technicians
in experimental planning and conduct of animal studies for better job satisfaction
and science'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21776'
abstract:
- lang: eng
text: Pyridyl motifs equipped with N-substituents can be powerful ligands for catalysis,
yet their broader adoption is limited by the lack of a practical method to prepare
these scaffolds. We report a modular, robust, and versatile Buchwald–Hartwig amination
protocol that enables the rapid synthesis of bipyridine, phenanthroline, terpyridine,
and pybox ligands bearing dialkylamine, diarylamine, and heteroaromatic N-substituents.
These conditions streamline ligand library synthesis and will facilitate systematic
studies in catalysis and related applications.
acknowledged_ssus:
- _id: LifeSc
- _id: MassSpec
- _id: NMR
- _id: M-Shop
acknowledgement: We gratefully acknowledge ISTA for generous financial support. B.P.
acknowledges the Austrian Science Fund (PAT 1250924) and the ACS GCI Pharmaceutical
Roundtable for funding; T.P.Y acknowledges the NSF(CHE-2349003) for financial support.
This research was supported by the Scientific Service Units (SSU) of ISTA through
resources provided by the Lab Support Facility, Mass Spec Facility, NMR facility,
and the Miba Machine Shop. We specifically thank Aikaterina Paraskevopoulou for
HRMS measurements and Jan Pecak for support with ICP-OES experi-ments. NMR facilities
at UW−Madison were supported by the NSF(CHE-1048642) and a generous gift from Paul
J. and Margaret M. Bender. Open Access funding provided by Institute of Science
and Technology Austria/KEMÖ. This study was supported by Austrian Science Fund (PAT
1250924), ACSGCI Pharmaceutical Roundtable, and National Science Foundation(CHE-2349003)
and (CHE-1048642).
article_number: e70417
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Adam
full_name: Petrik, Adam
id: e273d403-329f-11ee-a353-8c34c056f8ed
last_name: Petrik
- first_name: Aleksander
full_name: Bena, Aleksander
id: 4197c39e-e8ec-11ed-86cb-afed934cd664
last_name: Bena
- first_name: Haralds
full_name: Baunis, Haralds
id: 2eea55ec-e8ec-11ed-86cb-d9c76787acfe
last_name: Baunis
- first_name: Riley M.
full_name: Kelch, Riley M.
last_name: Kelch
- first_name: Tehshik P.
full_name: Yoon, Tehshik P.
last_name: Yoon
- first_name: Bartholomäus
full_name: Pieber, Bartholomäus
id: 93e5e5b2-0da6-11ed-8a41-af589a024726
last_name: Pieber
orcid: 0000-0001-8689-388X
citation:
ama: Petrik A, Bena A, Baunis H, Kelch RM, Yoon TP, Pieber B. Facile access to N-substituted
pyridyl ligands. Advanced Synthesis & Catalysis. 2026;368(9). doi:10.1002/adsc.70417
apa: Petrik, A., Bena, A., Baunis, H., Kelch, R. M., Yoon, T. P., & Pieber,
B. (2026). Facile access to N-substituted pyridyl ligands. Advanced Synthesis
& Catalysis. Wiley. https://doi.org/10.1002/adsc.70417
chicago: Petrik, Adam, Aleksander Bena, Haralds Baunis, Riley M. Kelch, Tehshik
P. Yoon, and Bartholomäus Pieber. “Facile Access to N-Substituted Pyridyl Ligands.”
Advanced Synthesis & Catalysis. Wiley, 2026. https://doi.org/10.1002/adsc.70417.
ieee: A. Petrik, A. Bena, H. Baunis, R. M. Kelch, T. P. Yoon, and B. Pieber, “Facile
access to N-substituted pyridyl ligands,” Advanced Synthesis & Catalysis,
vol. 368, no. 9. Wiley, 2026.
ista: Petrik A, Bena A, Baunis H, Kelch RM, Yoon TP, Pieber B. 2026. Facile access
to N-substituted pyridyl ligands. Advanced Synthesis & Catalysis. 368(9),
e70417.
mla: Petrik, Adam, et al. “Facile Access to N-Substituted Pyridyl Ligands.” Advanced
Synthesis & Catalysis, vol. 368, no. 9, e70417, Wiley, 2026, doi:10.1002/adsc.70417.
short: A. Petrik, A. Bena, H. Baunis, R.M. Kelch, T.P. Yoon, B. Pieber, Advanced
Synthesis & Catalysis 368 (2026).
corr_author: '1'
date_created: 2026-05-03T22:01:36Z
date_published: 2026-05-05T00:00:00Z
date_updated: 2026-05-07T07:33:33Z
day: '05'
ddc:
- '540'
department:
- _id: BaPi
- _id: GradSch
doi: 10.1002/adsc.70417
file:
- access_level: open_access
checksum: afe9752977898642c903abdc70b4a283
content_type: application/pdf
creator: dernst
date_created: 2026-05-07T07:29:24Z
date_updated: 2026-05-07T07:29:24Z
file_id: '21833'
file_name: 2026_AdvSynthCatal_Petrik.pdf
file_size: 437184
relation: main_file
success: 1
file_date_updated: 2026-05-07T07:29:24Z
has_accepted_license: '1'
intvolume: ' 368'
issue: '9'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
project:
- _id: 8f1d607d-16d5-11f0-9cad-ab453295ba5e
grant_number: PAT 1250924
name: Photoactive ligands for transformative nickel catalysis
publication: Advanced Synthesis & Catalysis
publication_identifier:
eissn:
- 1615-4169
issn:
- 1615-4150
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Facile access to N-substituted pyridyl ligands
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 368
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21777'
abstract:
- lang: eng
text: The advantageous characteristics attributed to the 19F nucleus have made it
a popular target for nuclear magnetic resonance (NMR) once again in recent years.
Aside from solution NMR, an increasing number of studies have been conducted applying
solid-state magic-angle spinning (MAS) NMR to fluorine-labelled samples. Here,
the high chemical shift anisotropy and strong dipolar couplings can be utilised
to get structural insights into proteins and measure long distances. Despite increasing
popularity and promising benefits, the sensitivity of biomolecular 19F MAS NMR
often suffers from slow longitudinal T1 relaxation and therefore long recycle
delays. In this work, we expand paramagnetic doping, an approach commonly used
to reduce proton T1 relaxation times, to 19F-labelled biological samples. We study
the effect of Gd(DTPA) and Gd(DTPA-BMA) on 19F T1 and T2, and 13C T1 and T2 relaxation
in a [5-19F13C]-tryptophan-labelled protein via 19F-detected MAS NMR experiments.
The observed paramagnetic relaxation enhancement substantially reduces measurement
times of 19F MAS NMR experiments without compromising resolution. Additionally,
we report the chemical shift assignments of all four fluorotryptophan signals
in the 12×39 kDa-large protein TET2 using a mutagenesis approach.
acknowledged_ssus:
- _id: NMR
- _id: LifeSc
acknowledgement: We thank Ben P. Tatman for insightful discussions. This research
was supported by the Scientific Service Units (SSUs) of ISTA through resources provided
by the Nuclear Magnetic Resonance Facility and the Lab Support Facility. We thank
Prof. Tobias Madl (Medical University Graz) for a sample of Omniscan. Lea M. Becker
is the recipient of a DOC fellowship of the Austrian Academy of Sciences at the
Institute of Science and Technology Austria (grant no. PR10660EAW01).
article_processing_charge: Yes
article_type: original
author:
- first_name: Lea Marie
full_name: Becker, Lea Marie
id: 36336939-eb97-11eb-a6c2-c83f1214ca79
last_name: Becker
orcid: 0000-0002-6401-5151
- first_name: Giorgia
full_name: Toscano, Giorgia
id: 334a5e40-8747-11f0-b671-ba1f5154b4b4
last_name: Toscano
- first_name: Anna
full_name: Kapitonova, Anna
id: 9fb2a840-89e1-11ee-a8b7-cc5c7ba62471
last_name: Kapitonova
- first_name: Rajkumar
full_name: Singh, Rajkumar
id: a3089acd-6806-11ee-bacc-f0c7d500ad20
last_name: Singh
- first_name: Undina
full_name: Guillerm, Undina
id: bb74f472-ae54-11eb-9835-bc9c22fb1183
last_name: Guillerm
- first_name: Roman J.
full_name: Lichtenecker, Roman J.
last_name: Lichtenecker
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
citation:
ama: Becker LM, Toscano G, Kapitonova A, et al. Accelerated 19F biomolecular magic-angle
spinning NMR with paramagnetic dopants. Magnetic Resonance. 2026;7(1):29-37.
doi:10.5194/mr-7-29-2026
apa: Becker, L. M., Toscano, G., Kapitonova, A., Singh, R., Guillerm, U., Lichtenecker,
R. J., & Schanda, P. (2026). Accelerated 19F biomolecular magic-angle spinning
NMR with paramagnetic dopants. Magnetic Resonance. Copernicus Publications.
https://doi.org/10.5194/mr-7-29-2026
chicago: Becker, Lea Marie, Giorgia Toscano, Anna Kapitonova, Rajkumar Singh, Undina
Guillerm, Roman J. Lichtenecker, and Paul Schanda. “Accelerated 19F Biomolecular
Magic-Angle Spinning NMR with Paramagnetic Dopants.” Magnetic Resonance.
Copernicus Publications, 2026. https://doi.org/10.5194/mr-7-29-2026.
ieee: L. M. Becker et al., “Accelerated 19F biomolecular magic-angle spinning
NMR with paramagnetic dopants,” Magnetic Resonance, vol. 7, no. 1. Copernicus
Publications, pp. 29–37, 2026.
ista: Becker LM, Toscano G, Kapitonova A, Singh R, Guillerm U, Lichtenecker RJ,
Schanda P. 2026. Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic
dopants. Magnetic Resonance. 7(1), 29–37.
mla: Becker, Lea Marie, et al. “Accelerated 19F Biomolecular Magic-Angle Spinning
NMR with Paramagnetic Dopants.” Magnetic Resonance, vol. 7, no. 1, Copernicus
Publications, 2026, pp. 29–37, doi:10.5194/mr-7-29-2026.
short: L.M. Becker, G. Toscano, A. Kapitonova, R. Singh, U. Guillerm, R.J. Lichtenecker,
P. Schanda, Magnetic Resonance 7 (2026) 29–37.
corr_author: '1'
date_created: 2026-05-03T22:01:36Z
date_published: 2026-04-16T00:00:00Z
date_updated: 2026-05-07T06:49:59Z
day: '16'
ddc:
- '540'
department:
- _id: PaSc
- _id: GradSch
doi: 10.5194/mr-7-29-2026
external_id:
pmid:
- '42057802'
has_accepted_license: '1'
intvolume: ' 7'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.5194/mr-7-29-2026
month: '04'
oa: 1
oa_version: Published Version
page: 29-37
pmid: 1
project:
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
- _id: 7be609c4-9f16-11ee-852c-85015ce2b9b0
grant_number: '26777'
name: Exploring protein dynamics by solid-state MAS NMR through specific labeling
approaches
publication: Magnetic Resonance
publication_identifier:
eissn:
- 2699-0016
publication_status: published
publisher: Copernicus Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21778'
abstract:
- lang: eng
text: "We prove that every \U0001D43F-bilipschitz mapping ℤ 2 → ℝ2 canbe extended
to a \U0001D436(\U0001D43F)-bilipschitz mapping ℝ2 → ℝ2,and we provide a polynomial
upper bound for \U0001D436(\U0001D43F).Moreover, we extend the result to every
separated netin ℝ2 instead of ℤ 2, with the upper bound gaininga polynomial dependence
on the separation and netconstants associated to the given separated net. Thisanswers
an Oberwolfach question of Navas from 2015and is also a positive solution of the
two-dimensionalform of a decades old open (in all dimensions at leasttwo) problem
due to Alestalo Trotsenko and Väisälä."
acknowledgement: The authors wish to thank Professor Leonid Kovalev for a valuable
observation on the first versionof this work, which led to improved estimates and
cleaner proofs in Section 6. The present workdeveloped from a research visit of
Michael Dymond to Vojtěch Kaluža at IST Austria, funded by aLondon Mathematical
Society Research in Pairs grant. This work was done whilst Vojtěch Kalužawas fully
funded by the Austria Science Fund (FWF) [M 3100-N].
article_number: e70540
article_processing_charge: Yes (in subscription journal)
article_type: original
arxiv: 1
author:
- first_name: Michael
full_name: Dymond, Michael
last_name: Dymond
- first_name: Vojtech
full_name: Kaluza, Vojtech
id: 21AE5134-9EAC-11EA-BEA2-D7BD3DDC885E
last_name: Kaluza
orcid: 0000-0002-2512-8698
citation:
ama: Dymond M, Kaluza V. Planar bilipschitz extension from separated nets. Journal
of the London Mathematical Society. 2026;113(4). doi:10.1112/jlms.70540
apa: Dymond, M., & Kaluza, V. (2026). Planar bilipschitz extension from separated
nets. Journal of the London Mathematical Society. Wiley. https://doi.org/10.1112/jlms.70540
chicago: Dymond, Michael, and Vojtech Kaluza. “Planar Bilipschitz Extension from
Separated Nets.” Journal of the London Mathematical Society. Wiley, 2026.
https://doi.org/10.1112/jlms.70540.
ieee: M. Dymond and V. Kaluza, “Planar bilipschitz extension from separated nets,”
Journal of the London Mathematical Society, vol. 113, no. 4. Wiley, 2026.
ista: Dymond M, Kaluza V. 2026. Planar bilipschitz extension from separated nets.
Journal of the London Mathematical Society. 113(4), e70540.
mla: Dymond, Michael, and Vojtech Kaluza. “Planar Bilipschitz Extension from Separated
Nets.” Journal of the London Mathematical Society, vol. 113, no. 4, e70540,
Wiley, 2026, doi:10.1112/jlms.70540.
short: M. Dymond, V. Kaluza, Journal of the London Mathematical Society 113 (2026).
date_created: 2026-05-03T22:01:37Z
date_published: 2026-04-01T00:00:00Z
date_updated: 2026-05-07T08:29:18Z
day: '01'
ddc:
- '510'
department:
- _id: UlWa
doi: 10.1112/jlms.70540
external_id:
arxiv:
- '2410.22294'
file:
- access_level: open_access
checksum: 6dbfc7134f732d17c5c8467843a73e90
content_type: application/pdf
creator: dernst
date_created: 2026-05-07T08:27:43Z
date_updated: 2026-05-07T08:27:43Z
file_id: '21836'
file_name: 2026_JourLondonMathSoc_Dymond.pdf
file_size: 617569
relation: main_file
success: 1
file_date_updated: 2026-05-07T08:27:43Z
has_accepted_license: '1'
intvolume: ' 113'
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: fc35eaa2-9c52-11eb-aca3-88501ab155e9
grant_number: M03100
name: Spectra and topology of graphs and of simplicial complexes
publication: Journal of the London Mathematical Society
publication_identifier:
eissn:
- 1469-7750
issn:
- 0024-6107
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Planar bilipschitz extension from separated nets
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 113
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21779'
abstract:
- lang: eng
text: Acidomycin is an anti-mycobacterial antibiotic with a unique mode of action,
targeting the biotin biosynthesis pathway. Despite being highly active against
mycobacteria in vitro, its development as an anti-tubercular agent has been hindered
due to suboptimal pharmacokinetics. Engineering of the acidomycin biosynthesis
may yield new analogues with improved pharmacological properties. Here, we describe
the identification of the acidomycin biosynthetic gene cluster (BGC) in a Streptomyces
bacterium isolated from the rhizosphere of Edelweiss. Notably, the acidomycin
BGC is located in proximity to the genes for the biosynthesis of stravidins, secondary
metabolites targeting a different enzyme in the biotin biosynthesis pathway, and
two genes for streptavidins, proteins that strongly bind and sequester biotin.
The identity of the acidomycin BGC was confirmed via both gene knock-out and heterologous
expression, which suggested that the fatty acid required for the formation of
acidomycin's acyl chain is most likely scavenged from the biotin biosynthesis
pathway. CRISPR/Cas9-assisted knock-out of the cytochrome P450-encoding gene in
the acidomycin BGC resulted in a significant decrease in its yield but did not
abrogate the biosynthesis completely.
acknowledgement: This work was supported by the University of Vienna. The authors
thank Anna Fabisikova from the Mass Spectrometry Centre and the team of the NMR
Centre (both of the Faculty of Chemistry, University of Vienna and members of the
Vienna Life Science Instruments) for assistance with data acquisition. Open Access
funding provided by Universitat Wien. This work was supported by Universität Wien.
article_number: e70357
article_processing_charge: Yes
article_type: original
author:
- first_name: Anna
full_name: Vignolle, Anna
last_name: Vignolle
- first_name: Martin
full_name: Zehl, Martin
id: 8e016d5b-5d77-11f0-86d2-96cdb3922a55
last_name: Zehl
orcid: 0000-0001-9685-0373
- first_name: Jaime Felipe Guerrero
full_name: Garzón, Jaime Felipe Guerrero
last_name: Garzón
- first_name: Olha
full_name: Schneider, Olha
last_name: Schneider
- first_name: Johannes
full_name: Gafriller, Johannes
last_name: Gafriller
- first_name: Ulrike
full_name: Grienke, Ulrike
last_name: Grienke
- first_name: Rasmus H.
full_name: Kirkegaard, Rasmus H.
last_name: Kirkegaard
- first_name: Sergey B.
full_name: Zotchev, Sergey B.
last_name: Zotchev
citation:
ama: Vignolle A, Zehl M, Garzón JFG, et al. Identification and characterisation
of the gene cluster governing biosynthesis of the anti-mycobacterial antibiotic
acidomycin. Microbial Biotechnology. 2026;19(4). doi:10.1111/1751-7915.70357
apa: Vignolle, A., Zehl, M., Garzón, J. F. G., Schneider, O., Gafriller, J., Grienke,
U., … Zotchev, S. B. (2026). Identification and characterisation of the gene cluster
governing biosynthesis of the anti-mycobacterial antibiotic acidomycin. Microbial
Biotechnology. Wiley. https://doi.org/10.1111/1751-7915.70357
chicago: Vignolle, Anna, Martin Zehl, Jaime Felipe Guerrero Garzón, Olha Schneider,
Johannes Gafriller, Ulrike Grienke, Rasmus H. Kirkegaard, and Sergey B. Zotchev.
“Identification and Characterisation of the Gene Cluster Governing Biosynthesis
of the Anti-Mycobacterial Antibiotic Acidomycin.” Microbial Biotechnology.
Wiley, 2026. https://doi.org/10.1111/1751-7915.70357.
ieee: A. Vignolle et al., “Identification and characterisation of the gene
cluster governing biosynthesis of the anti-mycobacterial antibiotic acidomycin,”
Microbial Biotechnology, vol. 19, no. 4. Wiley, 2026.
ista: Vignolle A, Zehl M, Garzón JFG, Schneider O, Gafriller J, Grienke U, Kirkegaard
RH, Zotchev SB. 2026. Identification and characterisation of the gene cluster
governing biosynthesis of the anti-mycobacterial antibiotic acidomycin. Microbial
Biotechnology. 19(4), e70357.
mla: Vignolle, Anna, et al. “Identification and Characterisation of the Gene Cluster
Governing Biosynthesis of the Anti-Mycobacterial Antibiotic Acidomycin.” Microbial
Biotechnology, vol. 19, no. 4, e70357, Wiley, 2026, doi:10.1111/1751-7915.70357.
short: A. Vignolle, M. Zehl, J.F.G. Garzón, O. Schneider, J. Gafriller, U. Grienke,
R.H. Kirkegaard, S.B. Zotchev, Microbial Biotechnology 19 (2026).
date_created: 2026-05-03T22:01:37Z
date_published: 2026-04-01T00:00:00Z
date_updated: 2026-05-07T08:22:41Z
day: '01'
ddc:
- '570'
department:
- _id: MassSpec
doi: 10.1111/1751-7915.70357
external_id:
pmid:
- '42036976'
file:
- access_level: open_access
checksum: 8c8aa660cef5394167e06f187adbabf0
content_type: application/pdf
creator: dernst
date_created: 2026-05-07T08:21:06Z
date_updated: 2026-05-07T08:21:06Z
file_id: '21835'
file_name: 2026_MicrobialBiotechnology_Vignolle.pdf
file_size: 575492
relation: main_file
success: 1
file_date_updated: 2026-05-07T08:21:06Z
has_accepted_license: '1'
intvolume: ' 19'
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
publication: Microbial Biotechnology
publication_identifier:
eissn:
- 1751-7915
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Identification and characterisation of the gene cluster governing biosynthesis
of the anti-mycobacterial antibiotic acidomycin
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21780'
abstract:
- lang: eng
text: It is predicted that half or more of all cataclysmic variables (CVs) should
have evolved past the period minimum and now exist as so-called period bouncers
where a white dwarf should be accreting from a Roche lobe filling substellar companion.
However, this prediction stands in stark contrast to observations, where only
a few per cent of CVs are found in this evolutionary phase. A potential solution
to this discrepancy is that a magnetic field emerges from within the white dwarf
after the system has reached the period minimum. The transfer of angular momentum
from the spin of the white dwarf into the orbit then pushes the two stars apart,
detaching them for potentially billions of years. Here we present the discovery
of ZTF J021804.16+071152.93, a detached 0.69 +- 0.01 M, 19 MG magnetic white
dwarf plus 37 +- 5MJup brown dwarf binary with an orbital period of 1.7 h. The
kinematics of the system indicate that it is a high probability member of the
Galactic thick disc. However, this strongly disagrees with the much younger age
of the system obtained from the white dwarf parameters, implying that the system
may have been accreting in the past. This system is therefore consistent with
having detached as a result of the emergence of the magnetic field of the white
dwarf when the system was still mass transferring, and may represent the ultimate
fate for many (perhaps even most) CVs.
acknowledgement: "The results presented in this paper are based on observations collected
at the European Southern Observatory under programme IDs 113.D-0277 and 114.D-0066
and on observations made with the Gran Telescopio Canarias (programme ID GTC119-23B),
installed in the Spanish Observatorio del Roque de los Muchachos of the Instituto
de Astrofísica de Canarias, on the island of La Palma.\r\n\r\nSGP acknowledges support
by the Science and Technology Facilities Council (grant ST/B001174/1). ARM acknowledges
support from MINECO under the PID2023-148661NB-I00 grant and by the AGAUR/Generalitat
de Catalunya grant SGR-386/2021. RMO was funded by INTA through grant PRE-OBSERVATORIO
and acknowledges support from project PID2023-146210NB-I00 funded by MICIU/AEI/10.13039/501100011033
and by ERDF/EU. MZ acknowledges support from FONDECYT (grants 1250525 and 1221059).
VSD and HiPERCAM were funded by the Science and Technology Facilities Council (grant
ST/Z000033/1). MRS thanks for support from FONDECYT (grant No. 1221059). This project
received funding from the European Research Council under the European Union’s Horizon
2020 research and innovation programme (Grant agreement numbers 101002408-MOS100PC)."
article_number: stag521
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: S. G.
full_name: Parsons, S. G.
last_name: Parsons
- first_name: A. J.
full_name: Brown, A. J.
last_name: Brown
- first_name: S. L.
full_name: Casewell, S. L.
last_name: Casewell
- first_name: S. P.
full_name: Littlefair, S. P.
last_name: Littlefair
- first_name: Joannes C
full_name: van Roestel, Joannes C
id: 4d122fc8-6083-11f0-87a5-97d68b860333
last_name: van Roestel
- first_name: A.
full_name: Rebassa-Mansergas, A.
last_name: Rebassa-Mansergas
- first_name: R.
full_name: Murillo-Ojeda, R.
last_name: Murillo-Ojeda
- first_name: M.
full_name: Zorotovic, M.
last_name: Zorotovic
- first_name: M. R.
full_name: Schreiber, M. R.
last_name: Schreiber
- first_name: S.
full_name: Bagnulo, S.
last_name: Bagnulo
- first_name: M. A.
full_name: Stroet, M. A.
last_name: Stroet
- first_name: N.
full_name: Castro Segura, N.
last_name: Castro Segura
- first_name: V. S.
full_name: Dhillon, V. S.
last_name: Dhillon
- first_name: M. J.
full_name: Dyer, M. J.
last_name: Dyer
- first_name: J. A.
full_name: Garbutt, J. A.
last_name: Garbutt
- first_name: M. J.
full_name: Green, M. J.
last_name: Green
- first_name: D.
full_name: Jarvis, D.
last_name: Jarvis
- first_name: M. R.
full_name: Kennedy, M. R.
last_name: Kennedy
- first_name: P.
full_name: Kerry, P.
last_name: Kerry
- first_name: J.
full_name: Mccormac, J.
last_name: Mccormac
- first_name: J.
full_name: Munday, J.
last_name: Munday
- first_name: I.
full_name: Pelisoli, I.
last_name: Pelisoli
- first_name: E.
full_name: Pike, E.
last_name: Pike
- first_name: D. I.
full_name: Sahman, D. I.
last_name: Sahman
- first_name: A.
full_name: Yates, A.
last_name: Yates
citation:
ama: 'Parsons SG, Brown AJ, Casewell SL, et al. ZTF J021804.16+071152.93: A dead
cataclysmic variable and potential solution to the missing period bouncer cataclysmic
variables. Monthly Notices of the Royal Astronomical Society. 2026;547(4).
doi:10.1093/mnras/stag521'
apa: 'Parsons, S. G., Brown, A. J., Casewell, S. L., Littlefair, S. P., van Roestel,
J. C., Rebassa-Mansergas, A., … Yates, A. (2026). ZTF J021804.16+071152.93: A
dead cataclysmic variable and potential solution to the missing period bouncer
cataclysmic variables. Monthly Notices of the Royal Astronomical Society.
Oxford University Press. https://doi.org/10.1093/mnras/stag521'
chicago: 'Parsons, S. G., A. J. Brown, S. L. Casewell, S. P. Littlefair, Joannes
C van Roestel, A. Rebassa-Mansergas, R. Murillo-Ojeda, et al. “ZTF J021804.16+071152.93:
A Dead Cataclysmic Variable and Potential Solution to the Missing Period Bouncer
Cataclysmic Variables.” Monthly Notices of the Royal Astronomical Society.
Oxford University Press, 2026. https://doi.org/10.1093/mnras/stag521.'
ieee: 'S. G. Parsons et al., “ZTF J021804.16+071152.93: A dead cataclysmic
variable and potential solution to the missing period bouncer cataclysmic variables,”
Monthly Notices of the Royal Astronomical Society, vol. 547, no. 4. Oxford
University Press, 2026.'
ista: 'Parsons SG, Brown AJ, Casewell SL, Littlefair SP, van Roestel JC, Rebassa-Mansergas
A, Murillo-Ojeda R, Zorotovic M, Schreiber MR, Bagnulo S, Stroet MA, Castro Segura
N, Dhillon VS, Dyer MJ, Garbutt JA, Green MJ, Jarvis D, Kennedy MR, Kerry P, Mccormac
J, Munday J, Pelisoli I, Pike E, Sahman DI, Yates A. 2026. ZTF J021804.16+071152.93:
A dead cataclysmic variable and potential solution to the missing period bouncer
cataclysmic variables. Monthly Notices of the Royal Astronomical Society. 547(4),
stag521.'
mla: 'Parsons, S. G., et al. “ZTF J021804.16+071152.93: A Dead Cataclysmic Variable
and Potential Solution to the Missing Period Bouncer Cataclysmic Variables.” Monthly
Notices of the Royal Astronomical Society, vol. 547, no. 4, stag521, Oxford
University Press, 2026, doi:10.1093/mnras/stag521.'
short: S.G. Parsons, A.J. Brown, S.L. Casewell, S.P. Littlefair, J.C. van Roestel,
A. Rebassa-Mansergas, R. Murillo-Ojeda, M. Zorotovic, M.R. Schreiber, S. Bagnulo,
M.A. Stroet, N. Castro Segura, V.S. Dhillon, M.J. Dyer, J.A. Garbutt, M.J. Green,
D. Jarvis, M.R. Kennedy, P. Kerry, J. Mccormac, J. Munday, I. Pelisoli, E. Pike,
D.I. Sahman, A. Yates, Monthly Notices of the Royal Astronomical Society 547 (2026).
date_created: 2026-05-03T22:01:37Z
date_published: 2026-04-01T00:00:00Z
date_updated: 2026-05-07T07:51:58Z
day: '01'
ddc:
- '520'
department:
- _id: IlCa
doi: 10.1093/mnras/stag521
external_id:
arxiv:
- '2603.12888'
file:
- access_level: open_access
checksum: a64094199db4dedb12fc121b7c65fe97
content_type: application/pdf
creator: dernst
date_created: 2026-05-07T07:51:06Z
date_updated: 2026-05-07T07:51:06Z
file_id: '21834'
file_name: 2026_MNRAS_Parsons.pdf
file_size: 5955512
relation: main_file
success: 1
file_date_updated: 2026-05-07T07:51:06Z
has_accepted_license: '1'
intvolume: ' 547'
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'ZTF J021804.16+071152.93: A dead cataclysmic variable and potential solution
to the missing period bouncer cataclysmic variables'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 547
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21781'
abstract:
- lang: eng
text: "Given a set A of n points (vertices) in general position in the plane, the
complete geometric graph \r\nKn[A] consists of all (n2) segments (edges) between
the elements of A. It is known that the edge set of every complete geometric graph
on n vertices can be partitioned into O(n3∕2) crossing-free paths (or matchings).
We strengthen this result under various additional assumptions on the point set.
In particular, we prove that for a set A of n randomly selected points, uniformly
distributed in [0,1]2, with probability tending to 1 as n→∞, the edge set of Kn[A]
can be covered by O(nlogn) crossing-free paths and by O(n√logn) crossing-free
matchings. On the other hand, we construct n-element point sets such that covering
the edge set of Kn[A] requires a quadratic number of monotone paths."
acknowledgement: "Research partially supported by ERC Advanced Grant \"GeoScape\",
no. 882971 and\r\nHungarian NKFIH grant no. K-131529. Work by the third author is
supported by EPSRC grant\r\nEP/X013642/1. Work by the third author is partially
supported by the European Research Council (ERC), grant no. 788183, and by the Wittgenstein
Prize, Austrian Science Fund (FWF), grant no. Z 342-N31."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Adrian
full_name: Dumitrescu, Adrian
last_name: Dumitrescu
- first_name: János
full_name: Pach, János
last_name: Pach
- first_name: Morteza
full_name: Saghafian, Morteza
id: f86f7148-b140-11ec-9577-95435b8df824
last_name: Saghafian
- first_name: Alex
full_name: Scott, Alex
last_name: Scott
citation:
ama: Dumitrescu A, Pach J, Saghafian M, Scott A. Covering complete geometric graphs
by monotone paths. Combinatorics and Number Theory. 2026;15(1):73-82. doi:10.2140/cnt.2026.15.73
apa: Dumitrescu, A., Pach, J., Saghafian, M., & Scott, A. (2026). Covering complete
geometric graphs by monotone paths. Combinatorics and Number Theory. Mathematical
Sciences Publishers. https://doi.org/10.2140/cnt.2026.15.73
chicago: Dumitrescu, Adrian, János Pach, Morteza Saghafian, and Alex Scott. “Covering
Complete Geometric Graphs by Monotone Paths.” Combinatorics and Number Theory.
Mathematical Sciences Publishers, 2026. https://doi.org/10.2140/cnt.2026.15.73.
ieee: A. Dumitrescu, J. Pach, M. Saghafian, and A. Scott, “Covering complete geometric
graphs by monotone paths,” Combinatorics and Number Theory, vol. 15, no.
1. Mathematical Sciences Publishers, pp. 73–82, 2026.
ista: Dumitrescu A, Pach J, Saghafian M, Scott A. 2026. Covering complete geometric
graphs by monotone paths. Combinatorics and Number Theory. 15(1), 73–82.
mla: Dumitrescu, Adrian, et al. “Covering Complete Geometric Graphs by Monotone
Paths.” Combinatorics and Number Theory, vol. 15, no. 1, Mathematical Sciences
Publishers, 2026, pp. 73–82, doi:10.2140/cnt.2026.15.73.
short: A. Dumitrescu, J. Pach, M. Saghafian, A. Scott, Combinatorics and Number
Theory 15 (2026) 73–82.
date_created: 2026-05-03T22:01:37Z
date_published: 2026-04-17T00:00:00Z
date_updated: 2026-05-07T07:45:24Z
day: '17'
department:
- _id: HeEd
doi: 10.2140/cnt.2026.15.73
ec_funded: 1
external_id:
arxiv:
- '2507.10840'
intvolume: ' 15'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2507.10840
month: '04'
oa: 1
oa_version: Preprint
page: 73-82
project:
- _id: 266A2E9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '788183'
name: Alpha Shape Theory Extended
- _id: 268116B8-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z00342
name: Mathematics, Computer Science
publication: Combinatorics and Number Theory
publication_identifier:
eissn:
- 2996-220X
issn:
- 2996-2196
publication_status: published
publisher: Mathematical Sciences Publishers
quality_controlled: '1'
scopus_import: '1'
status: public
title: Covering complete geometric graphs by monotone paths
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21798'
abstract:
- lang: eng
text: 'Phase singularities—points carrying quantized topological charge—are universal
features found across diverse wave systems from superfluids and superconductors
to acoustic and optical fields1,2,3,4. Ensembles of these singularities exhibit
distance correlations resembling particles in liquids5,6,7,8, extensively studied
for their role in exotic material phases9,10,11. By contrast, the full correlations
in phase space that govern the system evolution have remained unexplored and experimentally
inaccessible. Here we directly measure the ultrafast dynamics of optical singularity
ensembles, capturing their full phase-space correlations, presenting the joint
distance–velocity distribution. Our observations show a breakdown of the particle-singularity
analogy12: phase singularities accelerate towards formally divergent velocities
in the moment before annihilation7,13,14, indicated by measurements of velocities
exceeding the speed of light. These apparent superluminal velocities are paradoxically
amplified by the slow group velocity of hyperbolic phonon polaritons in our material
platform, hexagonal boron nitride membranes15,16,17,18,19. We demonstrate these
phenomena using combined hardware and algorithmic advances in ultrafast electron
microscopy18,20,21,22,23,24,25, achieving spatial and temporal resolutions, each
an order of magnitude below the polaritonic wavelength and cycle period. Our findings
deepen our understanding of phase singularities and their universality, enabling
to probe topological defect dynamics at previously unattainable timescales.'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: T.
full_name: Bucher, T.
last_name: Bucher
- first_name: A.
full_name: Gorlach, A.
last_name: Gorlach
- first_name: A.
full_name: Niedermayr, A.
last_name: Niedermayr
- first_name: Q.
full_name: Yan, Q.
last_name: Yan
- first_name: H.
full_name: Nahari, H.
last_name: Nahari
- first_name: K.
full_name: Wang, K.
last_name: Wang
- first_name: R.
full_name: Ruimy, R.
last_name: Ruimy
- first_name: Y.
full_name: Adiv, Y.
last_name: Adiv
- first_name: M.
full_name: Yannai, M.
last_name: Yannai
- first_name: T. L.
full_name: Abudi, T. L.
last_name: Abudi
- first_name: E.
full_name: Janzen, E.
last_name: Janzen
- first_name: C.
full_name: Spaegele, C.
last_name: Spaegele
- first_name: Charles
full_name: Roques-Carmes, Charles
id: e2e68fc9-6505-11ef-a541-eb4e72cc3e82
last_name: Roques-Carmes
- first_name: J. H.
full_name: Edgar, J. H.
last_name: Edgar
- first_name: F. H. L.
full_name: Koppens, F. H. L.
last_name: Koppens
- first_name: G. M.
full_name: Vanacore, G. M.
last_name: Vanacore
- first_name: H.
full_name: H. Sheinfux, H.
last_name: H. Sheinfux
- first_name: S.
full_name: Tsesses, S.
last_name: Tsesses
- first_name: I.
full_name: Kaminer, I.
last_name: Kaminer
citation:
ama: Bucher T, Gorlach A, Niedermayr A, et al. Superluminal correlations in ensembles
of optical phase singularities. Nature. 2026;651(8107):920-926. doi:10.1038/s41586-026-10209-z
apa: Bucher, T., Gorlach, A., Niedermayr, A., Yan, Q., Nahari, H., Wang, K., … Kaminer,
I. (2026). Superluminal correlations in ensembles of optical phase singularities.
Nature. Springer Nature. https://doi.org/10.1038/s41586-026-10209-z
chicago: Bucher, T., A. Gorlach, A. Niedermayr, Q. Yan, H. Nahari, K. Wang, R. Ruimy,
et al. “Superluminal Correlations in Ensembles of Optical Phase Singularities.”
Nature. Springer Nature, 2026. https://doi.org/10.1038/s41586-026-10209-z.
ieee: T. Bucher et al., “Superluminal correlations in ensembles of optical
phase singularities,” Nature, vol. 651, no. 8107. Springer Nature, pp.
920–926, 2026.
ista: Bucher T, Gorlach A, Niedermayr A, Yan Q, Nahari H, Wang K, Ruimy R, Adiv
Y, Yannai M, Abudi TL, Janzen E, Spaegele C, Roques-Carmes C, Edgar JH, Koppens
FHL, Vanacore GM, H. Sheinfux H, Tsesses S, Kaminer I. 2026. Superluminal correlations
in ensembles of optical phase singularities. Nature. 651(8107), 920–926.
mla: Bucher, T., et al. “Superluminal Correlations in Ensembles of Optical Phase
Singularities.” Nature, vol. 651, no. 8107, Springer Nature, 2026, pp.
920–26, doi:10.1038/s41586-026-10209-z.
short: T. Bucher, A. Gorlach, A. Niedermayr, Q. Yan, H. Nahari, K. Wang, R. Ruimy,
Y. Adiv, M. Yannai, T.L. Abudi, E. Janzen, C. Spaegele, C. Roques-Carmes, J.H.
Edgar, F.H.L. Koppens, G.M. Vanacore, H. H. Sheinfux, S. Tsesses, I. Kaminer,
Nature 651 (2026) 920–926.
date_created: 2026-05-05T11:05:31Z
date_published: 2026-03-25T00:00:00Z
date_updated: 2026-05-05T11:10:07Z
day: '25'
doi: 10.1038/s41586-026-10209-z
extern: '1'
external_id:
arxiv:
- '2509.17675'
intvolume: ' 651'
issue: '8107'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2509.17675
month: '03'
oa: 1
oa_version: Preprint
page: 920-926
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Superluminal correlations in ensembles of optical phase singularities
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 651
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21800'
abstract:
- lang: eng
text: 'LAMMPS input scripts to simulate toroidal vesicles composed of pure bolalipid
membranes and archaeal mixture membranes for the following publication: "Cracking
donuts and sorting lipids: geometry controls archaeal membrane stability and lipid
organization" by Felix Frey, Miguel Amaral, and Andela Saric.'
article_processing_charge: No
author:
- first_name: Felix F
full_name: Frey, Felix F
id: a0270b37-8f1a-11ec-95c7-8e710c59a4f3
last_name: Frey
orcid: 0000-0001-8501-6017
- first_name: Miguel
full_name: Santana de Freitas Amaral, Miguel
id: 4f2d02dd-47a9-11ec-ad10-82820ed3f501
last_name: Santana de Freitas Amaral
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
citation:
ama: 'Frey FF, Santana de Freitas Amaral M, Šarić A. Cracking donuts and sorting
lipids: Geometry controls archaeal membrane stability and lipid organization.
2026. doi:10.5281/ZENODO.18772086'
apa: 'Frey, F. F., Santana de Freitas Amaral, M., & Šarić, A. (2026). Cracking
donuts and sorting lipids: Geometry controls archaeal membrane stability and lipid
organization. Zenodo. https://doi.org/10.5281/ZENODO.18772086'
chicago: 'Frey, Felix F, Miguel Santana de Freitas Amaral, and Anđela Šarić. “Cracking
Donuts and Sorting Lipids: Geometry Controls Archaeal Membrane Stability and Lipid
Organization.” Zenodo, 2026. https://doi.org/10.5281/ZENODO.18772086.'
ieee: 'F. F. Frey, M. Santana de Freitas Amaral, and A. Šarić, “Cracking donuts
and sorting lipids: Geometry controls archaeal membrane stability and lipid organization.”
Zenodo, 2026.'
ista: 'Frey FF, Santana de Freitas Amaral M, Šarić A. 2026. Cracking donuts and
sorting lipids: Geometry controls archaeal membrane stability and lipid organization,
Zenodo, 10.5281/ZENODO.18772086.'
mla: 'Frey, Felix F., et al. Cracking Donuts and Sorting Lipids: Geometry Controls
Archaeal Membrane Stability and Lipid Organization. Zenodo, 2026, doi:10.5281/ZENODO.18772086.'
short: F.F. Frey, M. Santana de Freitas Amaral, A. Šarić, (2026).
corr_author: '1'
date_created: 2026-05-05T12:11:52Z
date_published: 2026-02-25T00:00:00Z
date_updated: 2026-05-05T12:40:41Z
day: '25'
ddc:
- '540'
department:
- _id: AnSa
doi: 10.5281/ZENODO.18772086
main_file_link:
- open_access: '1'
url: https://doi.org/10.5281/ZENODO.18772086
month: '02'
oa: 1
oa_version: Published Version
publisher: Zenodo
related_material:
record:
- id: '21748'
relation: used_in_publication
status: public
status: public
title: 'Cracking donuts and sorting lipids: Geometry controls archaeal membrane stability
and lipid organization'
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21837'
abstract:
- lang: eng
text: 'In a warming world of glacier changes, the scientific community has dedicated
increasing attention to debris-covered glaciers and their response to climate.
A variety of models with distinct complexity and data requirements have been developed
and widely used to simulate melt under debris at different sites and scales, but
their skills have never been compared. As part of the activities of the International
Association of Cryospheric Sciences (IACS) Debris Covered Glacier Working Group,
we present an intercomparison exercise aimed at advancing our understanding of
model skills in simulating ice melt under a debris layer. We compare 15 models
with different complexity at nine sites in the European Alps, Caucasus, Chilean
Andes, Nepalese Himalaya and the Southern Alps of New Zealand, over one melt season.
We run the models with measured meteorological data from automatic weather stations
and estimated or measured debris properties. We consider four main model categories:
(i) energy balance models that calculate melt by solving the physics of heat transfer
to the debris layer, but require a high amount of input data; (ii) a simplified
energy balance model; (iii) enhanced temperature-index models; and (iv) simple
empirical temperature-index models that have been extensively used given their
low data requirement but require calibration of their empirical parameters. Model
performance is evaluated using on-site measurements of sub-debris melt (for all
models) and surface temperature (for models based on the surface energy balance).
Our results show that physically-based energy balance models and empirical temperature-index
models perform in a distinct manner. At one end of the spectrum, simple temperature-index
models are accurate when recalibrated or when using site-specific literature parameters,
and show poor results when parameters are uncalibrated. At the other end, energy
balance models show a range of performance: the most accurate energy balance models
are those with the highest degree of complexity at the atmosphere-debris interface.
An important data gap emerged from our experiment: the poor performance of all
models at three sites was related to the poor knowledge of debris properties,
and specifically of thermal conductivity. Future work should focus on both: (i) consistent
data acquisition to evaluate existing models and support new model developments;
(ii) advancing models by accounting for processes such as debris-snow interactions,
moisture in the debris and refreezing. We suggest that a systematic effort of
model development using a common model framework could be carried out in phase
II of the Working Group.'
acknowledgement: "This project has received funding from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme
grant agreement No\r\n772751, RAVEN, “Rapid mass losses of debris covered glaciers
in\r\nHigh Mountain Asia”. It was also supported by the SNSF RENOIR\r\nproject “Resolving
the thickness of debris on Earth’s glaciers and\r\nits rate of change (RENOIR)”,
project number 204322.\r\nDavid Rounce received support from NASA-ROSES program\r\ngrants
NNX17AB27G and 80NSSC17K0566. Walter Immerzeel\r\nand Jakob Steiner acknowledge
support from the European Research Council (ERC) under the European Union’s Horizon
2020\r\nresearch and innovation program (grant agreement no. 676819).\r\nBen Brock
acknowledges support from the EU/FP7 ACQWA\r\n(Assessing Climate impacts on the
Quantity and quality of WAter) project, NERC grant NE/C514282/1, the British Council-Italian\r\nMinistry
of University and Research Partnership programme and\r\nthe Carnegie Trust for the
Universities of Scotland.\r\nThe authors acknowledge the International Association
of\r\nCryospheric Sciences (IACS) for supporting the creation of the\r\nDebris-Covered
Glaciers Working Group (DCG-WG) which enabled this model intercomparison experiment.\r\nThe
authors thank Martin Heynen for producing Figs. 3 and 4.\r\nThe authors thank Duncan
Quincey and Richard Essery for their\r\nconstructive feedback and comments.\r\n"
article_processing_charge: Yes
article_type: original
author:
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
orcid: 0000-0002-5554-8087
- first_name: Adrià
full_name: Fontrodona-Bach, Adrià
id: f06891fd-9f42-11ee-8632-a20971c43046
last_name: Fontrodona-Bach
- first_name: David R.
full_name: Rounce, David R.
last_name: Rounce
- first_name: Catriona Louise
full_name: Fyffe, Catriona Louise
id: 001b0422-8d15-11ed-bc51-cab6c037a228
last_name: Fyffe
- first_name: Leif S.
full_name: Anderson, Leif S.
last_name: Anderson
- first_name: Álvaro
full_name: Ayala, Álvaro
last_name: Ayala
- first_name: Ben W.
full_name: Brock, Ben W.
last_name: Brock
- first_name: Pascal
full_name: Buri, Pascal
last_name: Buri
- first_name: Stefan
full_name: Fugger, Stefan
last_name: Fugger
- first_name: Koji
full_name: Fujita, Koji
last_name: Fujita
- first_name: PRATEEK
full_name: GANTAYAT, PRATEEK
id: 02734268-3e8d-11ef-80a1-cec4a088d004
last_name: GANTAYAT
- first_name: Alexander R.
full_name: Groos, Alexander R.
last_name: Groos
- first_name: Walter
full_name: Immerzeel, Walter
last_name: Immerzeel
- first_name: Marin
full_name: Kneib, Marin
last_name: Kneib
- first_name: Christoph
full_name: Mayer, Christoph
last_name: Mayer
- first_name: Shelley
full_name: MacDonell, Shelley
last_name: MacDonell
- first_name: Michael
full_name: McCarthy, Michael
id: 22a2674a-61ce-11ee-94b5-d18813baf16f
last_name: McCarthy
- first_name: James
full_name: McPhee, James
last_name: McPhee
- first_name: Evan
full_name: Miles, Evan
last_name: Miles
- first_name: Heather
full_name: Purdie, Heather
last_name: Purdie
- first_name: Ekaterina
full_name: Rets, Ekaterina
last_name: Rets
- first_name: Akiko
full_name: Sakai, Akiko
last_name: Sakai
- first_name: Thomas
full_name: Shaw, Thomas
id: 3caa3f91-1f03-11ee-96ce-e0e553054d6e
last_name: Shaw
orcid: 0000-0001-7640-6152
- first_name: Jakob
full_name: Steiner, Jakob
last_name: Steiner
- first_name: Patrick
full_name: Wagnon, Patrick
last_name: Wagnon
- first_name: Alex
full_name: Winter-Billington, Alex
last_name: Winter-Billington
citation:
ama: 'Pellicciotti F, Fontrodona-Bach A, Rounce DR, et al. DCG-MIP: The debris-covered
glacier melt model intercomparison experiment. The Cryosphere. 2026;20(3):1895-1928.
doi:10.5194/tc-20-1895-2026'
apa: 'Pellicciotti, F., Fontrodona-Bach, A., Rounce, D. R., Fyffe, C. L., Anderson,
L. S., Ayala, Á., … Winter-Billington, A. (2026). DCG-MIP: The debris-covered
glacier melt model intercomparison experiment. The Cryosphere. Copernicus
Publications. https://doi.org/10.5194/tc-20-1895-2026'
chicago: 'Pellicciotti, Francesca, Adrià Fontrodona-Bach, David R. Rounce, Catriona
Louise Fyffe, Leif S. Anderson, Álvaro Ayala, Ben W. Brock, et al. “DCG-MIP: The
Debris-Covered Glacier Melt Model Intercomparison Experiment.” The Cryosphere.
Copernicus Publications, 2026. https://doi.org/10.5194/tc-20-1895-2026.'
ieee: 'F. Pellicciotti et al., “DCG-MIP: The debris-covered glacier melt
model intercomparison experiment,” The Cryosphere, vol. 20, no. 3. Copernicus
Publications, pp. 1895–1928, 2026.'
ista: 'Pellicciotti F, Fontrodona-Bach A, Rounce DR, Fyffe CL, Anderson LS, Ayala
Á, Brock BW, Buri P, Fugger S, Fujita K, GANTAYAT P, Groos AR, Immerzeel W, Kneib
M, Mayer C, MacDonell S, McCarthy M, McPhee J, Miles E, Purdie H, Rets E, Sakai
A, Shaw T, Steiner J, Wagnon P, Winter-Billington A. 2026. DCG-MIP: The debris-covered
glacier melt model intercomparison experiment. The Cryosphere. 20(3), 1895–1928.'
mla: 'Pellicciotti, Francesca, et al. “DCG-MIP: The Debris-Covered Glacier Melt
Model Intercomparison Experiment.” The Cryosphere, vol. 20, no. 3, Copernicus
Publications, 2026, pp. 1895–928, doi:10.5194/tc-20-1895-2026.'
short: F. Pellicciotti, A. Fontrodona-Bach, D.R. Rounce, C.L. Fyffe, L.S. Anderson,
Á. Ayala, B.W. Brock, P. Buri, S. Fugger, K. Fujita, P. GANTAYAT, A.R. Groos,
W. Immerzeel, M. Kneib, C. Mayer, S. MacDonell, M. McCarthy, J. McPhee, E. Miles,
H. Purdie, E. Rets, A. Sakai, T. Shaw, J. Steiner, P. Wagnon, A. Winter-Billington,
The Cryosphere 20 (2026) 1895–1928.
corr_author: '1'
date_created: 2026-05-07T08:48:38Z
date_published: 2026-04-02T00:00:00Z
date_updated: 2026-05-18T06:12:56Z
day: '02'
ddc:
- '550'
department:
- _id: FrPe
doi: 10.5194/tc-20-1895-2026
file:
- access_level: open_access
checksum: f15abad4ee360d41a3e8794f068711fc
content_type: application/pdf
creator: dernst
date_created: 2026-05-18T06:07:53Z
date_updated: 2026-05-18T06:07:53Z
file_id: '21886'
file_name: 2026_Cryosphere_Pellicciotti.pdf
file_size: 3168394
relation: main_file
success: 1
file_date_updated: 2026-05-18T06:07:53Z
has_accepted_license: '1'
intvolume: ' 20'
issue: '3'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 1895-1928
publication: The Cryosphere
publication_identifier:
eissn:
- 1994-0424
publication_status: published
publisher: Copernicus Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'DCG-MIP: The debris-covered glacier melt model intercomparison experiment'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21838'
abstract:
- lang: eng
text: We explore the use of a photoacid in a chemical reaction cycle, which allows
for the controlled sol‐to‐gel transition of a saccharide aldehyde‐based self‐assembling
system. The modulation of the pH with light enables to generate chemical fuels
in situ, thus triggering monomer activation and gelation. Our efforts represent
a promising step toward dissipative self‐assembled systems with a higher degree
of spatiotemporal control.
acknowledgement: J.S.V. and T.M.H. acknowledge funding from ERC-2017-STG “Life-Cycle”
(757910) and ERC-2022-CoG “Suprabot” (101087514). A.L-A. acknowledges the European
Union's Horizon 2020 Research and Innovation Program under the Marie Skłodowska-Curie
grant agreement no. 812868 for Ph.D. funding. R.K. acknowledges support through
the Award for Research Cooperation and High Excellence in Science (ARCHES) from
the Federal German Ministry and Research.
article_number: e70037
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Alvaro
full_name: Lopez‐Acosta, Alvaro
last_name: Lopez‐Acosta
- first_name: Jorge S.
full_name: Valera, Jorge S.
last_name: Valera
- first_name: Rafal
full_name: Klajn, Rafal
id: 8e84690e-1e48-11ed-a02b-a1e6fb8bb53b
last_name: Klajn
- first_name: Thomas M.
full_name: Hermans, Thomas M.
last_name: Hermans
citation:
ama: Lopez‐Acosta A, Valera JS, Klajn R, Hermans TM. Photoacid‐mediated controllable
gelation in a chemical reaction cycle. ChemSystemsChem. 2026;8(3). doi:10.1002/syst.70037
apa: Lopez‐Acosta, A., Valera, J. S., Klajn, R., & Hermans, T. M. (2026). Photoacid‐mediated
controllable gelation in a chemical reaction cycle. ChemSystemsChem. Wiley.
https://doi.org/10.1002/syst.70037
chicago: Lopez‐Acosta, Alvaro, Jorge S. Valera, Rafal Klajn, and Thomas M. Hermans.
“Photoacid‐mediated Controllable Gelation in a Chemical Reaction Cycle.” ChemSystemsChem.
Wiley, 2026. https://doi.org/10.1002/syst.70037.
ieee: A. Lopez‐Acosta, J. S. Valera, R. Klajn, and T. M. Hermans, “Photoacid‐mediated
controllable gelation in a chemical reaction cycle,” ChemSystemsChem, vol.
8, no. 3. Wiley, 2026.
ista: Lopez‐Acosta A, Valera JS, Klajn R, Hermans TM. 2026. Photoacid‐mediated controllable
gelation in a chemical reaction cycle. ChemSystemsChem. 8(3), e70037.
mla: Lopez‐Acosta, Alvaro, et al. “Photoacid‐mediated Controllable Gelation in a
Chemical Reaction Cycle.” ChemSystemsChem, vol. 8, no. 3, e70037, Wiley,
2026, doi:10.1002/syst.70037.
short: A. Lopez‐Acosta, J.S. Valera, R. Klajn, T.M. Hermans, ChemSystemsChem 8 (2026).
date_created: 2026-05-07T08:51:01Z
date_published: 2026-04-06T00:00:00Z
date_updated: 2026-05-18T06:59:10Z
day: '06'
ddc:
- '540'
department:
- _id: RaKl
doi: 10.1002/syst.70037
file:
- access_level: open_access
checksum: c51e985ac2f2cefb273fdf2cc6ab87e4
content_type: application/pdf
creator: dernst
date_created: 2026-05-18T06:29:57Z
date_updated: 2026-05-18T06:29:57Z
file_id: '21887'
file_name: 2026_ChemSystemsChem_LopezAcosta.pdf
file_size: 1118636
relation: main_file
success: 1
file_date_updated: 2026-05-18T06:29:57Z
has_accepted_license: '1'
intvolume: ' 8'
issue: '3'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
publication: ChemSystemsChem
publication_identifier:
eissn:
- 2570-4206
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Photoacid‐mediated controllable gelation in a chemical reaction cycle
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21839'
abstract:
- lang: eng
text: "Background & Aims: To develop and validate a CT-based radiomics model to
assess HVPG and predict a composite endpoint of liver-related events (LRE: decompensation
and liver-related death) in patients with cirrhosis.\r\n\r\nMethods: This retrospective
study included 357 cirrhosis patients, who received invasive HVPG measurements,
120 liver-healthy controls (training cohort) and 85 and 100 cirrhosis patients
(internal and external validation cohorts, respectively), and contrast-enhanced
abdominal CTs. After volumetric segmentation of the liver and spleen on CT, Bayesian
parameter optimization was used for selection of extracted features and hyperparameter
tuning in random forest or elastic net models. Prediction accuracy was evaluated
using Pearson correlation coefficients of predicted (’radio-HVPG’) and invasive
HVPG. Discrimination between relevant HVPG cut-offs was determined by receiver
operating characteristic (ROC) analysis. The predictive value of radio-HVPG and
invasive-HVPG for LRE was compared using Cox regression models.\r\n\r\nResults:
Radio-HVPG, predicted by an optimized random forest model based on 74 selected
CT features, correlated with invasive-HVPG and detected clinically significant
portal hypertension (CSPH: HVPG ≥ 10 mmHg) on the internal (Pearson r = 0.63,
AUC 0.89 [95% CI: 0.81–0.96]) and external (Pearson r = 0.62, AUC 0.80 [95% CI:
0.64–0.91]) validation cohorts. Radio-HVPG predicted LRE when adjusting for MELD
and albumin (adjusted HR: 1.14 [95% CI: 1.04–1.25], p = 0.005) and performed similarly
to invasive-HVPG.\r\n\r\nConclusions: Radiomic features accurately predict HVPG
in patients with cirrhosis and allow risk stratification for LRE in a radiomics-clinical
signature."
acknowledgement: "The computational results presented were partly obtained using the
CLIP cluster (https://clip.science/). The authors thank Clemens Watzenboeck from
the Medical University of Vienna for the assistance in code upload and repository
maintenance. The authors dedicate this work to the memory of Martin Watzenboeck,
who served as first author and whose vision and scientific rigor were fundamental
to the conception and completion of this study. Open Access funding provided by
Medizinische Universitat Wien/KEMÖ. This work was supported by the Vienna Science
and Technology Fund (WWTF) through projects VRG15-005 and NXT 19-008 granted to
J.M and the Clinical Research Group MOTION, Medical University of Vienna, Vienna,
Austria – a Clinical Research Group Programme project funded by the Ludwig Boltzmann
Gesellschaft (Grant Nr LBG_KFG_22_32) with funds from the Fonds Zukunft Österreich.\r\n\r\nP-E.R.'s
research laboratory is supported by the Fondation pour la Recherche Médicale (FRM
EQU202303016287), “Institut National de la Santé et de la Recherche Médicale” (ATIP
AVENIR), the “Agence Nationale de la Recherche” (ANR-18-CE14-0006-01, RHU QUID-NASH,
ANR-18-IDEX-0001, ANR-22-CE14-0002) by « Émergence, Ville de Paris », by Fondation
ARC, by the European Union's Horizon 2020 research and innovation programme under
grant agreement No 847949 and by France 2030 RHU LIVER-TRACK."
article_number: e70633
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Celine
full_name: Sin, Celine
last_name: Sin
- first_name: Martin Luther
full_name: Watzenboeck, Martin Luther
last_name: Watzenboeck
- first_name: Eugenia B
full_name: Iofinova, Eugenia B
id: f9a17499-f6e0-11ea-865d-fdf9a3f77117
last_name: Iofinova
orcid: 0000-0002-7778-3221
- first_name: Lorenz
full_name: Balcar, Lorenz
last_name: Balcar
- first_name: Georg
full_name: Semmler, Georg
last_name: Semmler
- first_name: Bernhard
full_name: Scheiner, Bernhard
last_name: Scheiner
- first_name: Katharina
full_name: Lampichler, Katharina
last_name: Lampichler
- first_name: Mattias
full_name: Mandorfer, Mattias
last_name: Mandorfer
- first_name: Lucile
full_name: Moga, Lucile
last_name: Moga
- first_name: Pierre‐Emmanuel
full_name: Rautou, Pierre‐Emmanuel
last_name: Rautou
- first_name: Maxime
full_name: Ronot, Maxime
last_name: Ronot
- first_name: Jörg
full_name: Menche, Jörg
last_name: Menche
- first_name: Thomas
full_name: Reiberger, Thomas
last_name: Reiberger
- first_name: Martina
full_name: Scharitzer, Martina
last_name: Scharitzer
citation:
ama: Sin C, Watzenboeck ML, Iofinova EB, et al. Radiomics‐based assessment of portal
hypertension severity and risk stratification of cirrhotic patients using routine
CT scans. Liver International. 2026;46(5). doi:10.1111/liv.70633
apa: Sin, C., Watzenboeck, M. L., Iofinova, E. B., Balcar, L., Semmler, G., Scheiner,
B., … Scharitzer, M. (2026). Radiomics‐based assessment of portal hypertension
severity and risk stratification of cirrhotic patients using routine CT scans.
Liver International. Wiley. https://doi.org/10.1111/liv.70633
chicago: Sin, Celine, Martin Luther Watzenboeck, Eugenia B Iofinova, Lorenz Balcar,
Georg Semmler, Bernhard Scheiner, Katharina Lampichler, et al. “Radiomics‐based
Assessment of Portal Hypertension Severity and Risk Stratification of Cirrhotic
Patients Using Routine CT Scans.” Liver International. Wiley, 2026. https://doi.org/10.1111/liv.70633.
ieee: C. Sin et al., “Radiomics‐based assessment of portal hypertension severity
and risk stratification of cirrhotic patients using routine CT scans,” Liver
International, vol. 46, no. 5. Wiley, 2026.
ista: Sin C, Watzenboeck ML, Iofinova EB, Balcar L, Semmler G, Scheiner B, Lampichler
K, Mandorfer M, Moga L, Rautou P, Ronot M, Menche J, Reiberger T, Scharitzer M.
2026. Radiomics‐based assessment of portal hypertension severity and risk stratification
of cirrhotic patients using routine CT scans. Liver International. 46(5), e70633.
mla: Sin, Celine, et al. “Radiomics‐based Assessment of Portal Hypertension Severity
and Risk Stratification of Cirrhotic Patients Using Routine CT Scans.” Liver
International, vol. 46, no. 5, e70633, Wiley, 2026, doi:10.1111/liv.70633.
short: C. Sin, M.L. Watzenboeck, E.B. Iofinova, L. Balcar, G. Semmler, B. Scheiner,
K. Lampichler, M. Mandorfer, L. Moga, P. Rautou, M. Ronot, J. Menche, T. Reiberger,
M. Scharitzer, Liver International 46 (2026).
date_created: 2026-05-07T08:51:47Z
date_published: 2026-05-01T00:00:00Z
date_updated: 2026-05-18T07:20:20Z
day: '01'
ddc:
- '570'
doi: 10.1111/liv.70633
external_id:
pmid:
- '41943460'
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- access_level: open_access
checksum: fafcc0b88b8e8caed85849627305d9ba
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creator: dernst
date_created: 2026-05-18T07:10:31Z
date_updated: 2026-05-18T07:10:31Z
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success: 1
file_date_updated: 2026-05-18T07:10:31Z
has_accepted_license: '1'
intvolume: ' 46'
issue: '5'
keyword:
- computed tomography
- liver
- portal hypertension
- radiomics
- spleen
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
publication: Liver International
publication_identifier:
eissn:
- 1478-3231
issn:
- 1478-3223
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Radiomics‐based assessment of portal hypertension severity and risk stratification
of cirrhotic patients using routine CT scans
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
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short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 46
year: '2026'
...