---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21234'
abstract:
- lang: eng
  text: In aged humans and mice, hypobranched glycogen aggregates, known as polyglucosan
    bodies (PGBs), accumulate in hippocampal astrocytes. While PGBs are linked to
    cognitive decline in neurological diseases, they remain largely unstudied in the
    context of typical aging. We show that PGBs arise in autophagy-dysregulated astrocytes
    in the aged hippocampus, with substantial variation among 32 inbred BXD mouse
    strains. Genetic mapping through quantitative trait locus analysis identified
    a major locus (Pgb1) that modulates hippocampal PGB burden. Extensive transcriptomic
    and proteomic datasets were produced for the aged hippocampus of the BXD family
    to investigate the mechanism by which the Pgb1 locus modulates PGB burden. We
    identified that Pgb1 contains allelic Smarcal1 and Usp37 variants and influences
    PGB burden through trans-regulation of mRNA and protein expression levels, including
    abundance of glycogen-mobilizing factor PYGB. Furthermore, comprehensive phenome-wide
    association scans, transcriptomic analyses, and direct behavioral testing demonstrated
    that cognition remains intact despite age-related PGB burden. A record of this
    paper’s transparent peer review process is included in the supplemental information.
acknowledgement: We would like to thank the Summer School Systems Genetics of Neural
  Ageing for bringing us together and spurring our international collaboration. We
  would also like to acknowledge the funding for the Summer School 2022 from the e:Med
  Systems Medicine Program of the BMBF (Bundesministerium für Bildung und Forschung;
  German Ministry of Education and Research) to R.W.O. In addition, we would like
  to thank the FLI imaging core facility for their assistance. A.G.-P. is supported
  by Fundación Séneca, Región de Murcia, Spain (21259/FPI/19). D.E.M.d.B. is financed
  by a Rubicon scholarship (452021116) from the Dutch Research Council (NWO). This
  work was also supported by NIH NIA R01AG070913-01 (R.W.W.), R01AG075813-01 (D.G.A.),
  and R01AG075818 (C.K.). We acknowledge the help of Larry Mobraaten (Jackson Laboratory,
  Bar Harbor, MN) with the BXD strains and U. Obermüller for the help with the histology.
  For the purpose of open access, the authors have applied a CC BY public copyright
  license to all author-accepted manuscripts arising from this submission.
article_number: '101488'
article_processing_charge: No
article_type: original
author:
- first_name: Alicia
  full_name: Gómez-Pascual, Alicia
  last_name: Gómez-Pascual
- first_name: Dow M
  full_name: Glikman, Dow M
  id: ab8acda1-91c1-11f0-aad8-f75d3d6424d8
  last_name: Glikman
- first_name: Hui Xin
  full_name: Ng, Hui Xin
  last_name: Ng
- first_name: James E.
  full_name: Tomkins, James E.
  last_name: Tomkins
- first_name: Lu
  full_name: Lu, Lu
  last_name: Lu
- first_name: Ying
  full_name: Xu, Ying
  last_name: Xu
- first_name: David G.
  full_name: Ashbrook, David G.
  last_name: Ashbrook
- first_name: Catherine
  full_name: Kaczorowski, Catherine
  last_name: Kaczorowski
- first_name: Gerd
  full_name: Kempermann, Gerd
  last_name: Kempermann
- first_name: John
  full_name: Killmar, John
  last_name: Killmar
- first_name: Khyobeni
  full_name: Mozhui, Khyobeni
  last_name: Mozhui
- first_name: Oliver
  full_name: Ohlenschläger, Oliver
  last_name: Ohlenschläger
- first_name: Rudolf
  full_name: Aebersold, Rudolf
  last_name: Aebersold
- first_name: Donald K.
  full_name: Ingram, Donald K.
  last_name: Ingram
- first_name: Evan G.
  full_name: Williams, Evan G.
  last_name: Williams
- first_name: Mathias
  full_name: Jucker, Mathias
  last_name: Jucker
- first_name: Rupert W.
  full_name: Overall, Rupert W.
  last_name: Overall
- first_name: Robert W.
  full_name: Williams, Robert W.
  last_name: Williams
- first_name: Dennis E.M.
  full_name: de Bakker, Dennis E.M.
  last_name: de Bakker
citation:
  ama: Gómez-Pascual A, Glikman DM, Ng HX, et al. The Smarcal1-Usp37 locus modulates
    glycogen aggregation in astrocytes of the aged hippocampus. <i>Cell Systems</i>.
    2026;17(2). doi:<a href="https://doi.org/10.1016/j.cels.2025.101488">10.1016/j.cels.2025.101488</a>
  apa: Gómez-Pascual, A., Glikman, D. M., Ng, H. X., Tomkins, J. E., Lu, L., Xu, Y.,
    … de Bakker, D. E. M. (2026). The Smarcal1-Usp37 locus modulates glycogen aggregation
    in astrocytes of the aged hippocampus. <i>Cell Systems</i>. Elsevier. <a href="https://doi.org/10.1016/j.cels.2025.101488">https://doi.org/10.1016/j.cels.2025.101488</a>
  chicago: Gómez-Pascual, Alicia, Dow M Glikman, Hui Xin Ng, James E. Tomkins, Lu
    Lu, Ying Xu, David G. Ashbrook, et al. “The Smarcal1-Usp37 Locus Modulates Glycogen
    Aggregation in Astrocytes of the Aged Hippocampus.” <i>Cell Systems</i>. Elsevier,
    2026. <a href="https://doi.org/10.1016/j.cels.2025.101488">https://doi.org/10.1016/j.cels.2025.101488</a>.
  ieee: A. Gómez-Pascual <i>et al.</i>, “The Smarcal1-Usp37 locus modulates glycogen
    aggregation in astrocytes of the aged hippocampus,” <i>Cell Systems</i>, vol.
    17, no. 2. Elsevier, 2026.
  ista: Gómez-Pascual A, Glikman DM, Ng HX, Tomkins JE, Lu L, Xu Y, Ashbrook DG, Kaczorowski
    C, Kempermann G, Killmar J, Mozhui K, Ohlenschläger O, Aebersold R, Ingram DK,
    Williams EG, Jucker M, Overall RW, Williams RW, de Bakker DEM. 2026. The Smarcal1-Usp37
    locus modulates glycogen aggregation in astrocytes of the aged hippocampus. Cell
    Systems. 17(2), 101488.
  mla: Gómez-Pascual, Alicia, et al. “The Smarcal1-Usp37 Locus Modulates Glycogen
    Aggregation in Astrocytes of the Aged Hippocampus.” <i>Cell Systems</i>, vol.
    17, no. 2, 101488, Elsevier, 2026, doi:<a href="https://doi.org/10.1016/j.cels.2025.101488">10.1016/j.cels.2025.101488</a>.
  short: A. Gómez-Pascual, D.M. Glikman, H.X. Ng, J.E. Tomkins, L. Lu, Y. Xu, D.G.
    Ashbrook, C. Kaczorowski, G. Kempermann, J. Killmar, K. Mozhui, O. Ohlenschläger,
    R. Aebersold, D.K. Ingram, E.G. Williams, M. Jucker, R.W. Overall, R.W. Williams,
    D.E.M. de Bakker, Cell Systems 17 (2026).
date_created: 2026-02-16T10:45:10Z
date_published: 2026-02-18T00:00:00Z
date_updated: 2026-02-23T10:35:01Z
day: '18'
ddc:
- '570'
department:
- _id: GradSch
doi: 10.1016/j.cels.2025.101488
external_id:
  pmid:
  - '41633365'
file:
- access_level: open_access
  checksum: 920e8edfd3b8b42f5bb6f86d4c66c54d
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  creator: dernst
  date_created: 2026-02-23T10:32:12Z
  date_updated: 2026-02-23T10:32:12Z
  file_id: '21349'
  file_name: 2026_CellSystems_GomezPascual.pdf
  file_size: 10606778
  relation: main_file
  success: 1
file_date_updated: 2026-02-23T10:32:12Z
has_accepted_license: '1'
intvolume: '        17'
issue: '2'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: Cell Systems
publication_identifier:
  issn:
  - 2405-4712
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the
  aged hippocampus
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21242'
abstract:
- lang: eng
  text: We obtain an asymptotic formula for the number of integral solutions to a
    system of diagonal equations. We obtain an asymptotic formula for the number of
    solutions with variables restricted to smooth numbers as well. We improve the
    required number of variables compared to previous results by incorporating recent
    progress on Waring’s problem and the resolution of the main conjecture in Vinogradov’s
    mean value theorem.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Nick
  full_name: Rome, Nick
  last_name: Rome
- first_name: Shuntaro
  full_name: Yamagishi, Shuntaro
  id: 0c3fbc5c-f7a6-11ec-8d70-9485e75b416b
  last_name: Yamagishi
citation:
  ama: Rome N, Yamagishi S. Integral solutions to systems of diagonal equations. <i>Pacific
    Journal of Mathematics</i>. 2026;340(1):179-198. doi:<a href="https://doi.org/10.2140/pjm.2026.340.179">10.2140/pjm.2026.340.179</a>
  apa: Rome, N., &#38; Yamagishi, S. (2026). Integral solutions to systems of diagonal
    equations. <i>Pacific Journal of Mathematics</i>. Mathematical Sciences Publishers.
    <a href="https://doi.org/10.2140/pjm.2026.340.179">https://doi.org/10.2140/pjm.2026.340.179</a>
  chicago: Rome, Nick, and Shuntaro Yamagishi. “Integral Solutions to Systems of Diagonal
    Equations.” <i>Pacific Journal of Mathematics</i>. Mathematical Sciences Publishers,
    2026. <a href="https://doi.org/10.2140/pjm.2026.340.179">https://doi.org/10.2140/pjm.2026.340.179</a>.
  ieee: N. Rome and S. Yamagishi, “Integral solutions to systems of diagonal equations,”
    <i>Pacific Journal of Mathematics</i>, vol. 340, no. 1. Mathematical Sciences
    Publishers, pp. 179–198, 2026.
  ista: Rome N, Yamagishi S. 2026. Integral solutions to systems of diagonal equations.
    Pacific Journal of Mathematics. 340(1), 179–198.
  mla: Rome, Nick, and Shuntaro Yamagishi. “Integral Solutions to Systems of Diagonal
    Equations.” <i>Pacific Journal of Mathematics</i>, vol. 340, no. 1, Mathematical
    Sciences Publishers, 2026, pp. 179–98, doi:<a href="https://doi.org/10.2140/pjm.2026.340.179">10.2140/pjm.2026.340.179</a>.
  short: N. Rome, S. Yamagishi, Pacific Journal of Mathematics 340 (2026) 179–198.
date_created: 2026-02-16T15:17:27Z
date_published: 2026-01-01T00:00:00Z
date_updated: 2026-02-17T11:43:14Z
day: '01'
department:
- _id: TiBr
doi: 10.2140/pjm.2026.340.179
external_id:
  arxiv:
  - '2406.09256'
intvolume: '       340'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2406.09256
month: '01'
oa: 1
oa_version: Preprint
page: 179-198
publication: Pacific Journal of Mathematics
publication_identifier:
  eissn:
  - 1945-5844
  issn:
  - 0030-8730
publication_status: published
publisher: Mathematical Sciences Publishers
quality_controlled: '1'
status: public
title: Integral solutions to systems of diagonal equations
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 340
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21273'
abstract:
- lang: eng
  text: In this paper we examine how porosity fluctuations affect the hydrodynamic
    permeability of a porous matrix or membrane. We introduce a fluctuating Darcy
    model, which couples the Navier-Stokes equation to the space- and time-dependent
    porosity fluctuations via a Darcy friction term. Using a perturbative approach,
    a Dyson equation for hydrodynamic fluctuations is derived and solved to express
    the permeability in terms of the matrix fluctuation spectrum. Surprisingly, the
    model reveals strong modifications of the fluid permeability in fluctuating matrices
    compared to static ones. Applications to various matrix excitation models, the
    breathing matrix, phonons, and active forcing, highlight the significant influence
    of matrix fluctuations on fluid transport, offering insights for optimizing membrane
    design for separation applications.
acknowledgement: "The authors acknowledge support from ERC project n-AQUA, Grant Agreement
  No. 101071937.\r\nB.C. and A.S. acknowledge support from the CFM Foundation. B.C.
  acknowledges support from\r\nthe NOMIS Foundation."
article_number: '014201'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Albert
  full_name: Dombret, Albert
  last_name: Dombret
- first_name: Adrien
  full_name: Sutter, Adrien
  last_name: Sutter
- first_name: Baptiste
  full_name: Coquinot, Baptiste
  id: f8417bd4-f599-11ee-a482-b927e3ed1e8e
  last_name: Coquinot
  orcid: 0000-0001-5524-596X
- first_name: Nikita
  full_name: Kavokine, Nikita
  last_name: Kavokine
- first_name: Benoit
  full_name: Coasne, Benoit
  last_name: Coasne
- first_name: Lydéric
  full_name: Bocquet, Lydéric
  last_name: Bocquet
citation:
  ama: Dombret A, Sutter A, Coquinot B, Kavokine N, Coasne B, Bocquet L. Hydrodynamic
    permeability of fluctuating porous membranes. <i>Physical Review Fluids</i>. 2026;11(1).
    doi:<a href="https://doi.org/10.1103/m8h6-1wfk">10.1103/m8h6-1wfk</a>
  apa: Dombret, A., Sutter, A., Coquinot, B., Kavokine, N., Coasne, B., &#38; Bocquet,
    L. (2026). Hydrodynamic permeability of fluctuating porous membranes. <i>Physical
    Review Fluids</i>. American Physical Society. <a href="https://doi.org/10.1103/m8h6-1wfk">https://doi.org/10.1103/m8h6-1wfk</a>
  chicago: Dombret, Albert, Adrien Sutter, Baptiste Coquinot, Nikita Kavokine, Benoit
    Coasne, and Lydéric Bocquet. “Hydrodynamic Permeability of Fluctuating Porous
    Membranes.” <i>Physical Review Fluids</i>. American Physical Society, 2026. <a
    href="https://doi.org/10.1103/m8h6-1wfk">https://doi.org/10.1103/m8h6-1wfk</a>.
  ieee: A. Dombret, A. Sutter, B. Coquinot, N. Kavokine, B. Coasne, and L. Bocquet,
    “Hydrodynamic permeability of fluctuating porous membranes,” <i>Physical Review
    Fluids</i>, vol. 11, no. 1. American Physical Society, 2026.
  ista: Dombret A, Sutter A, Coquinot B, Kavokine N, Coasne B, Bocquet L. 2026. Hydrodynamic
    permeability of fluctuating porous membranes. Physical Review Fluids. 11(1), 014201.
  mla: Dombret, Albert, et al. “Hydrodynamic Permeability of Fluctuating Porous Membranes.”
    <i>Physical Review Fluids</i>, vol. 11, no. 1, 014201, American Physical Society,
    2026, doi:<a href="https://doi.org/10.1103/m8h6-1wfk">10.1103/m8h6-1wfk</a>.
  short: A. Dombret, A. Sutter, B. Coquinot, N. Kavokine, B. Coasne, L. Bocquet, Physical
    Review Fluids 11 (2026).
corr_author: '1'
date_created: 2026-02-17T08:10:09Z
date_published: 2026-01-21T00:00:00Z
date_updated: 2026-02-23T12:01:57Z
day: '21'
department:
- _id: MiLe
doi: 10.1103/m8h6-1wfk
external_id:
  arxiv:
  - '2512.11368'
intvolume: '        11'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2512.11368
month: '01'
oa: 1
oa_version: Preprint
publication: Physical Review Fluids
publication_identifier:
  eissn:
  - 2469-990X
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Hydrodynamic permeability of fluctuating porous membranes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21275'
abstract:
- lang: eng
  text: DNA methylation is a primary layer of epigenetic modification that plays a
    pivotal role in the regulation of development, aging, and cancer. The concurrent
    activity of opposing enzymes that mediate DNA methylation and demethylation gives
    rise to a biochemical cycle and active turnover of DNA methylation. While the
    ensuing biochemical oscillations have been implicated in the regulation of cell
    differentiation, their functional role and spatiotemporal dynamics are unknown.
    In this work, we demonstrate that chromatin-mediated coupling between these local
    biochemical cycles can lead to the emergence of phase-locked domains, regions
    of locally synchronized turnover activity, whose coarsening is arrested by genomic
    heterogeneity. We introduce a minimal model based on stochastic oscillators with
    constrained long-range and nonreciprocal interactions, shaped by the local chromatin
    organization. Through a combination of analytical theory and stochastic simulations,
    we predict both the degree of synchronization and the typical size of emergent
    phase-locked domains. We qualitatively test these predictions using single-cell
    sequencing data. Our results show that DNA methylation turnover exhibits surprisingly
    rich spatiotemporal patterns that may be used by cells to control cell differentiation.
acknowledgement: This project has received funding from the European Union's Horizon
  2020 research and innovation programme under Grant Agreement No. 950349 and the
  Marie Skłodowska-Curie Grant Agreement No. 101034413. The computations in this paper
  were run in part on the the FASRC Cannon cluster supported by the FAS Division of
  Science Research Computing Group at Harvard University and the cluster of the Max
  Planck Institute for the Physics of Complex Systems.
article_number: '013018'
article_processing_charge: Yes
article_type: original
author:
- first_name: Fabrizio
  full_name: Olmeda, Fabrizio
  id: 69dbf5fb-8a76-11ed-866b-fb486d8b5689
  last_name: Olmeda
- first_name: Misha
  full_name: Gupta, Misha
  last_name: Gupta
- first_name: Onurcan
  full_name: Bektas, Onurcan
  last_name: Bektas
- first_name: Steffen
  full_name: Rulands, Steffen
  last_name: Rulands
citation:
  ama: Olmeda F, Gupta M, Bektas O, Rulands S. Spatiotemporal patterns of active epigenetic
    turnover. <i>PRX Life</i>. 2026;4. doi:<a href="https://doi.org/10.1103/89bj-79g5">10.1103/89bj-79g5</a>
  apa: Olmeda, F., Gupta, M., Bektas, O., &#38; Rulands, S. (2026). Spatiotemporal
    patterns of active epigenetic turnover. <i>PRX Life</i>. American Physical Society.
    <a href="https://doi.org/10.1103/89bj-79g5">https://doi.org/10.1103/89bj-79g5</a>
  chicago: Olmeda, Fabrizio, Misha Gupta, Onurcan Bektas, and Steffen Rulands. “Spatiotemporal
    Patterns of Active Epigenetic Turnover.” <i>PRX Life</i>. American Physical Society,
    2026. <a href="https://doi.org/10.1103/89bj-79g5">https://doi.org/10.1103/89bj-79g5</a>.
  ieee: F. Olmeda, M. Gupta, O. Bektas, and S. Rulands, “Spatiotemporal patterns of
    active epigenetic turnover,” <i>PRX Life</i>, vol. 4. American Physical Society,
    2026.
  ista: Olmeda F, Gupta M, Bektas O, Rulands S. 2026. Spatiotemporal patterns of active
    epigenetic turnover. PRX Life. 4, 013018.
  mla: Olmeda, Fabrizio, et al. “Spatiotemporal Patterns of Active Epigenetic Turnover.”
    <i>PRX Life</i>, vol. 4, 013018, American Physical Society, 2026, doi:<a href="https://doi.org/10.1103/89bj-79g5">10.1103/89bj-79g5</a>.
  short: F. Olmeda, M. Gupta, O. Bektas, S. Rulands, PRX Life 4 (2026).
corr_author: '1'
date_created: 2026-02-17T08:17:53Z
date_published: 2026-02-09T00:00:00Z
date_updated: 2026-02-24T06:54:32Z
day: '09'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1103/89bj-79g5
ec_funded: 1
file:
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  checksum: df9776422862d1d02c66d98e2d620849
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  creator: dernst
  date_created: 2026-02-24T06:53:05Z
  date_updated: 2026-02-24T06:53:05Z
  file_id: '21351'
  file_name: 2026_PRXLife_Olmeda.pdf
  file_size: 5857833
  relation: main_file
  success: 1
file_date_updated: 2026-02-24T06:53:05Z
has_accepted_license: '1'
intvolume: '         4'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
publication: PRX Life
publication_identifier:
  eissn:
  - 2835-8279
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Spatiotemporal patterns of active epigenetic turnover
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21282'
abstract:
- lang: eng
  text: 'Developmental patterning comprises processes that range from purely instructed,
    where external signals specify cell fates, to fully self-organized, where spatial
    patterns emerge autonomously through cellular interactions. We propose that both
    extremes—as well as the continuum of intermediate cases—can be conceptualized
    as information-processing systems, whose operation can be described using “Marr''s
    three levels of analysis”: the computational problem being solved, the algorithms
    employed, and their molecular implementation. At the first level, we argue that
    normative theories, such as information-theoretic optimization principles, provide
    a formalization of the computational problem. At the second level, we show how
    simplified information-processing architectures provide a framework for developmental
    algorithms, which are formalized mathematically using dynamical systems theory.
    At the third level, the implementation of developmental algorithms is described
    by mechanistic biophysical and gene regulatory network models.'
acknowledgement: We thank Edouard Hannezo, Anna Kicheva, Fridtjof Brauns, and all
  members of the Brückner and Tkačik groups for feedback and inspiring discussions.
  This work was supported in part by European Research Council ERC-2023-SyG “Dynatrans”
  Grant No. 101118866 (G.T.). This work was conducted while visiting the Okinawa Institute
  of Science and Technology (OIST) through the Theoretical Sciences Visiting Program
  (TSVP); at the Kavli Institute for Theoretical Physics (KITP) Santa Barbara, supported
  by NSF Grant No. PHY-1748958 and the Gordon and Betty Moore Foundation Grant No.
  2919.02; and at Lucullus, Vienna.
article_number: '017001'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: David
  full_name: Brückner, David
  id: e1e86031-6537-11eb-953a-f7ab92be508d
  last_name: Brückner
  orcid: 0000-0001-7205-2975
- first_name: Gašper
  full_name: Tkačik, Gašper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkačik
  orcid: 0000-0002-6699-1455
citation:
  ama: 'Brückner D, Tkačik G. Marr’s three levels for embryonic development: Information,
    dynamical systems, gene networks. <i>PRX Life</i>. 2026;4. doi:<a href="https://doi.org/10.1103/fdcf-dkws">10.1103/fdcf-dkws</a>'
  apa: 'Brückner, D., &#38; Tkačik, G. (2026). Marr’s three levels for embryonic development:
    Information, dynamical systems, gene networks. <i>PRX Life</i>. American Physical
    Society. <a href="https://doi.org/10.1103/fdcf-dkws">https://doi.org/10.1103/fdcf-dkws</a>'
  chicago: 'Brückner, David, and Gašper Tkačik. “Marr’s Three Levels for Embryonic
    Development: Information, Dynamical Systems, Gene Networks.” <i>PRX Life</i>.
    American Physical Society, 2026. <a href="https://doi.org/10.1103/fdcf-dkws">https://doi.org/10.1103/fdcf-dkws</a>.'
  ieee: 'D. Brückner and G. Tkačik, “Marr’s three levels for embryonic development:
    Information, dynamical systems, gene networks,” <i>PRX Life</i>, vol. 4. American
    Physical Society, 2026.'
  ista: 'Brückner D, Tkačik G. 2026. Marr’s three levels for embryonic development:
    Information, dynamical systems, gene networks. PRX Life. 4, 017001.'
  mla: 'Brückner, David, and Gašper Tkačik. “Marr’s Three Levels for Embryonic Development:
    Information, Dynamical Systems, Gene Networks.” <i>PRX Life</i>, vol. 4, 017001,
    American Physical Society, 2026, doi:<a href="https://doi.org/10.1103/fdcf-dkws">10.1103/fdcf-dkws</a>.'
  short: D. Brückner, G. Tkačik, PRX Life 4 (2026).
corr_author: '1'
date_created: 2026-02-17T08:29:10Z
date_published: 2026-01-23T00:00:00Z
date_updated: 2026-02-24T07:00:16Z
day: '23'
ddc:
- '570'
department:
- _id: GaTk
doi: 10.1103/fdcf-dkws
external_id:
  arxiv:
  - '2510.24536'
file:
- access_level: open_access
  checksum: 99ef02dd741c4536eeefd12d409d5269
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-24T06:57:44Z
  date_updated: 2026-02-24T06:57:44Z
  file_id: '21352'
  file_name: 2026_PRXLife_Brueckner.pdf
  file_size: 1147994
  relation: main_file
  success: 1
file_date_updated: 2026-02-24T06:57:44Z
has_accepted_license: '1'
intvolume: '         4'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 7bfe6a29-9f16-11ee-852c-c0da5e2045d9
  grant_number: '101118866'
  name: 'Transcription in 4D: the dynamic interplay between chromatin architecture
    and gene expression in developing pseudo-embryos'
publication: PRX Life
publication_identifier:
  eissn:
  - 2835-8279
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: 'Marr''s three levels for embryonic development: Information, dynamical systems,
  gene networks'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2026'
...
---
OA_place: repository
OA_type: free access
_id: '21284'
abstract:
- lang: eng
  text: The advantageous characteristics attributed to the 19F nucleus have made it
    a popular target for NMR once again in recent years. Aside from solution NMR,
    an increasing number of studies have been conducted applying solid-state magic-angle-spinning
    NMR to fluorine-labeled samples. Here, the high chemical shift anisotropy and
    strong dipolar couplings can be utilized to get structural insights into proteins
    and measure long distances. Despite increasing popularity and promising benefits,
    the sensitivity of biomolecular 19F MAS NMR often suffers from slow longitudinal
    T1 relaxation and therefore long recycle delays. In this work, we expand paramagnetic
    doping, an approach commonly used to reduce proton T1 relaxation times, to 19F-labeled
    biological samples. We study the effect of Gd(DTPA) and Gd(DTPA-BMA) on 19F and
    13C T1 and T2 relaxation in a [5-19F13C]-tryptophan-labeled protein via 19F-detected
    MAS NMR experiments. The observed paramagnetic relaxation enhancement substantially
    reduces measurement times of 19F MAS NMR experiments without compromising resolution.
    Additionally, we report the chemical-shift assignments of all four fluorotryptophan
    signals in the 12 × 39 kDa large protein using a mutagenesis approach.
acknowledged_ssus:
- _id: NMR
- _id: LifeSc
acknowledgement: We thank Ben P. Tatman for insightful discussions. This research
  was supported by the Scientific Service Units (SSU) of Institute of Science and
  Technology Austria (ISTA) through resources provided by the Nuclear Magnetic Resonance
  Facility and the Lab Support Facility.
article_processing_charge: No
author:
- first_name: Lea Marie
  full_name: Becker, Lea Marie
  id: 36336939-eb97-11eb-a6c2-c83f1214ca79
  last_name: Becker
  orcid: 0000-0002-6401-5151
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
citation:
  ama: Becker LM, Schanda P. Research data for “Accelerated 19F biomolecular magic-angle
    spinning NMR with paramagnetic dopants.” 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-21284">10.15479/AT-ISTA-21284</a>
  apa: Becker, L. M., &#38; Schanda, P. (2026). Research data for “Accelerated 19F
    biomolecular magic-angle spinning NMR with paramagnetic dopants.” Institute of
    Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-21284">https://doi.org/10.15479/AT-ISTA-21284</a>
  chicago: Becker, Lea Marie, and Paul Schanda. “Research Data for ‘Accelerated 19F
    Biomolecular Magic-Angle Spinning NMR with Paramagnetic Dopants.’” Institute of
    Science and Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-21284">https://doi.org/10.15479/AT-ISTA-21284</a>.
  ieee: L. M. Becker and P. Schanda, “Research data for ‘Accelerated 19F biomolecular
    magic-angle spinning NMR with paramagnetic dopants.’” Institute of Science and
    Technology Austria, 2026.
  ista: Becker LM, Schanda P. 2026. Research data for ‘Accelerated 19F biomolecular
    magic-angle spinning NMR with paramagnetic dopants’, Institute of Science and
    Technology Austria, <a href="https://doi.org/10.15479/AT-ISTA-21284">10.15479/AT-ISTA-21284</a>.
  mla: Becker, Lea Marie, and Paul Schanda. <i>Research Data for “Accelerated 19F
    Biomolecular Magic-Angle Spinning NMR with Paramagnetic Dopants.”</i> Institute
    of Science and Technology Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-21284">10.15479/AT-ISTA-21284</a>.
  short: L.M. Becker, P. Schanda, (2026).
contributor:
- contributor_type: researcher
  first_name: Giorgia
  id: 334a5e40-8747-11f0-b671-ba1f5154b4b4
  last_name: Toscano
- contributor_type: researcher
  first_name: Anna
  id: 9fb2a840-89e1-11ee-a8b7-cc5c7ba62471
  last_name: Kapitonova
- contributor_type: researcher
  first_name: Rajkumar
  id: a3089acd-6806-11ee-bacc-f0c7d500ad20
  last_name: Singh
- contributor_type: researcher
  first_name: Undina
  id: bb74f472-ae54-11eb-9835-bc9c22fb1183
  last_name: Guillerm
- contributor_type: researcher
  first_name: Roman
  last_name: Lichtenecker
corr_author: '1'
date_created: 2026-02-17T10:17:14Z
date_published: 2026-02-18T00:00:00Z
date_updated: 2026-02-18T10:12:49Z
day: '18'
ddc:
- '541'
department:
- _id: GradSch
- _id: PaSc
doi: 10.15479/AT-ISTA-21284
file:
- access_level: open_access
  checksum: 2d3105f26be578073b88ee1f2ea0bdb1
  content_type: application/zip
  creator: lbecker
  date_created: 2026-02-17T10:11:14Z
  date_updated: 2026-02-17T10:11:14Z
  file_id: '21285'
  file_name: Research_data.zip
  file_size: 36996027
  relation: main_file
  success: 1
- access_level: open_access
  checksum: e24aebcdb8856cb181cbaa02de020ddb
  content_type: text/plain
  creator: lbecker
  date_created: 2026-02-17T10:11:14Z
  date_updated: 2026-02-17T10:11:14Z
  file_id: '21286'
  file_name: README.txt
  file_size: 1993
  relation: table_of_contents
file_date_updated: 2026-02-17T10:11:14Z
has_accepted_license: '1'
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '2'
oa: 1
oa_version: None
publisher: Institute of Science and Technology Austria
status: public
title: Research data for "Accelerated 19F biomolecular magic-angle spinning NMR with
  paramagnetic dopants"
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: research_data
user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21290'
abstract:
- lang: eng
  text: Gene duplication underlies evolutionary innovation, yet many paralogues remain
    highly similar, raising questions about their functional divergence and physiological
    relevance. The spliceosomal Sm core protein SNRPB and its mammalian-specific paralogue
    SNRPN share over 90% sequence identity, but their distinct expression patterns
    - SNRPB being ubiquitous and SNRPN confined to the brain - suggest specialized
    functions. Why mammals have two different spliceosomes has remained obscure. Here,
    we generated isogenic human cell lines expressing ectopically either SNRPB or
    SNRPN exclusively and found that SNRPN stabilizes transcripts involved in energy
    metabolism and mitochondrial function, leading to increased mitochondrial abundance
    and oxygen consumption. Despite similar spliceosomal interactomes, SNRPN more
    strongly associates with the PRMT5 methylosome complex and exhibits dynamic arginine
    methylation in its C-terminal region that is sensitive to translation inhibition
    and amino acid availability. The SNRPN-dependent transcriptome responds to translation
    inhibition by stabilizing long, intron-rich genes involved in amino acid and energy
    metabolism. Our findings reveal a nutrient-sensitive, methylation-dependent mechanism
    that differentiates the two paralogues. This suggests that SNRPN functions as
    a metabolic-specialized spliceosomal subunit thereby providing tissue-specific
    adaptation of RNA processing in mammals.
acknowledgement: "We thank Oliver Mühlemann and Alex Hofer (University of Bern) for
  sharing SMG inhibitors\r\nand for their expertise in nonsense-mediated mRNA decay
  and Maria Hondele for critical\r\nreading of the manuscript draft. We also thank
  the IMB Genomics Core Facility for assistance\r\nwith library preparation and sequencing,
  Martin Möckel and the IMB Protein Production Core\r\nFacility for providing enzymes
  used in this work, Marton Gelleri together with the IMB\r\nMicroscopy Core Facility
  for support with microscopy and FRAP experiments, Jasmin Cartano\r\nfor proteomics
  sample processing and the IMB Flow Cytometry Core Facility for support. In\r\naddition,
  we thank the Imaging Core Facility (IMCF) and the FACS Core Facility at the\r\nBiozentrum,
  University of Basel, for technical assistance. CIKV acknowledges funding by the\r\nDeutsche
  Forschungsgemeinschaft (DFG, German Research Foundation) - Individual Grant\r\nProject
  no. 513744403, Scientific Network Grant Project no. 531902894, GRK2526 “Genevo”\r\n-
  Project no. 407023052”, GRK2859 (“4R”) - Project no. 491145305, Forschungsinitiative\r\nRheinland-Pfalz
  (ReALity), the EMBO Young Investigator Program (5795), institutional\r\nfunding
  from the Institute of Molecular Biology and funds from the Kanton Basel-Stadt and\r\nBasel-Land
  provided to the Biozentrum of the University Basel. J.H.G.F.G. was part of the\r\n‘Science
  of Healthy Ageing Research Programme’ (SHARP) initiative funded by RhinelandPalatinate’s
  Ministry of Science, Education and Culture. PR is funded by the Biozentrum PhD\r\nFellowships
  Program. MFB received financial support from the intramural High Potentials\r\nGrant
  program of the University Medical Center Mainz, Forschungsinitiative Rheinland-Pfalz\r\n(ReALity)
  and Stiftungen zugunsten der Medizinischen Fakultät der LMU Klinikum (26069).\r\nInstruments
  in the IMB core facilities were supported by funds from the DFG: Laser Scanning\r\nConfocal
  (Leica Stellaris 8 Falcon, funded by the DFG - Project #497669232), Orbitrap Astral
  system (funded by the DFG - Project #524805621) and BD LSRFortessa SOPR is funded
  by\r\nthe DFG - Project #210253511.\r\n"
article_processing_charge: No
author:
- first_name: Feyza
  full_name: Polat Haas, Feyza
  last_name: Polat Haas
- first_name: Ana
  full_name: Villalba Requena, Ana
  id: 68cb85a0-39f7-11eb-9559-9aaab4f6a247
  last_name: Villalba Requena
  orcid: 0000-0002-5615-5277
- first_name: Polina
  full_name: Rusina, Polina
  last_name: Rusina
- first_name: Anusha
  full_name: Gopalan, Anusha
  last_name: Gopalan
- first_name: Hector
  full_name: Fritz, Hector
  last_name: Fritz
- first_name: Azamat
  full_name: Akhmetkaliyev, Azamat
  last_name: Akhmetkaliyev
- first_name: Frank
  full_name: Ruehle, Frank
  last_name: Ruehle
- first_name: Anna
  full_name: Einsiedel, Anna
  last_name: Einsiedel
- first_name: Anna
  full_name: Szczepinska, Anna
  last_name: Szczepinska
- first_name: Fridolin
  full_name: Kielisch, Fridolin
  last_name: Kielisch
- first_name: Jia-Xuan
  full_name: Chen, Jia-Xuan
  last_name: Chen
- first_name: Susanne
  full_name: Nguyen, Susanne
  last_name: Nguyen
- first_name: Thierry
  full_name: Schmidlin, Thierry
  last_name: Schmidlin
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: M. Felicia
  full_name: Bailicata, M. Felicia
  last_name: Bailicata
- first_name: Claudia Isabelle
  full_name: Keller Valsecchi, Claudia Isabelle
  last_name: Keller Valsecchi
citation:
  ama: Polat Haas F, Villalba Requena A, Rusina P, et al. The splicing paralogues
    SNRPB and SNRPN control differential metabolic states. <i>bioRxiv</i>. doi:<a
    href="https://doi.org/10.64898/2026.02.11.705284">10.64898/2026.02.11.705284</a>
  apa: Polat Haas, F., Villalba Requena, A., Rusina, P., Gopalan, A., Fritz, H., Akhmetkaliyev,
    A., … Keller Valsecchi, C. I. (n.d.). The splicing paralogues SNRPB and SNRPN
    control differential metabolic states. <i>bioRxiv</i>. <a href="https://doi.org/10.64898/2026.02.11.705284">https://doi.org/10.64898/2026.02.11.705284</a>
  chicago: Polat Haas, Feyza, Ana Villalba Requena, Polina Rusina, Anusha Gopalan,
    Hector Fritz, Azamat Akhmetkaliyev, Frank Ruehle, et al. “The Splicing Paralogues
    SNRPB and SNRPN Control Differential Metabolic States.” <i>BioRxiv</i>, n.d. <a
    href="https://doi.org/10.64898/2026.02.11.705284">https://doi.org/10.64898/2026.02.11.705284</a>.
  ieee: F. Polat Haas <i>et al.</i>, “The splicing paralogues SNRPB and SNRPN control
    differential metabolic states.,” <i>bioRxiv</i>. .
  ista: Polat Haas F, Villalba Requena A, Rusina P, Gopalan A, Fritz H, Akhmetkaliyev
    A, Ruehle F, Einsiedel A, Szczepinska A, Kielisch F, Chen J-X, Nguyen S, Schmidlin
    T, Hippenmeyer S, Bailicata MF, Keller Valsecchi CI. The splicing paralogues SNRPB
    and SNRPN control differential metabolic states. bioRxiv, <a href="https://doi.org/10.64898/2026.02.11.705284">10.64898/2026.02.11.705284</a>.
  mla: Polat Haas, Feyza, et al. “The Splicing Paralogues SNRPB and SNRPN Control
    Differential Metabolic States.” <i>BioRxiv</i>, doi:<a href="https://doi.org/10.64898/2026.02.11.705284">10.64898/2026.02.11.705284</a>.
  short: F. Polat Haas, A. Villalba Requena, P. Rusina, A. Gopalan, H. Fritz, A. Akhmetkaliyev,
    F. Ruehle, A. Einsiedel, A. Szczepinska, F. Kielisch, J.-X. Chen, S. Nguyen, T.
    Schmidlin, S. Hippenmeyer, M.F. Bailicata, C.I. Keller Valsecchi, BioRxiv (n.d.).
date_created: 2026-02-17T11:35:59Z
date_published: 2026-02-11T00:00:00Z
date_updated: 2026-02-23T11:03:33Z
day: '11'
department:
- _id: SiHi
doi: 10.64898/2026.02.11.705284
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.64898/2026.02.11.705284
month: '02'
oa: 1
oa_version: Preprint
publication: bioRxiv
publication_status: submitted
status: public
title: The splicing paralogues SNRPB and SNRPN control differential metabolic states.
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21295'
abstract:
- lang: eng
  text: 'Depending on the type of flow, the transition to turbulence can take one
    of two forms: either turbulence arises from a sequence of instabilities or from
    the spatial proliferation of transiently chaotic domains, a process analogous
    to directed percolation. The former scenario is commonly referred to as a supercritical
    transition and frequently encountered in flows destabilized by body forces, whereas
    the latter subcritical transition is common in shear flows. Both cases are inherently
    continuous in a sense that the transformation from ordered laminar to fully turbulent
    fluid motion is only accomplished gradually with flow speed. Here we show that
    these established transition types do not account for the more general setting
    of shear flows subject to body forces. The combination of the two continuous scenarios
    leads to the attenuation of spatial coupling; with increasing forcing amplitude,
    the transition becomes increasingly sharp and eventually discontinuous. We argue
    that the suppression of laminar–turbulent coexistence and the approach towards
    a discontinuous phase transition potentially apply to a broad range of situations
    including flows subject to, for example, buoyancy, centrifugal or electromagnetic
    forces.'
acknowledgement: The work was supported by the Simons Foundation (grant number 662960,
  to B.H.). Open access funding provided by Institute of Science and Technology (IST
  Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Bowen
  full_name: Yang, Bowen
  id: 71b6ff4b-15b2-11ec-abd3-aef6b028cf7e
  last_name: Yang
  orcid: 0000-0002-4843-6853
- first_name: Yi
  full_name: Zhuang, Yi
  id: 3677B57C-F248-11E8-B48F-1D18A9856A87
  last_name: Zhuang
- first_name: Gökhan
  full_name: Yalniz, Gökhan
  id: 66E74FA2-D8BF-11E9-8249-8DE2E5697425
  last_name: Yalniz
  orcid: 0000-0002-8490-9312
- first_name: Mukund
  full_name: Vasudevan, Mukund
  id: 3C5A959A-F248-11E8-B48F-1D18A9856A87
  last_name: Vasudevan
- first_name: Elena
  full_name: Marensi, Elena
  id: 0BE7553A-1004-11EA-B805-18983DDC885E
  last_name: Marensi
  orcid: 0000-0001-7173-4923
- first_name: Björn
  full_name: Hof, Björn
  id: 3A374330-F248-11E8-B48F-1D18A9856A87
  last_name: Hof
  orcid: 0000-0003-2057-2754
citation:
  ama: Yang B, Zhuang Y, Yalniz G, Vasudevan M, Marensi E, Hof B. Discontinuous transition
    to shear flow turbulence. <i>Nature Physics</i>. 2026. doi:<a href="https://doi.org/10.1038/s41567-025-03166-3">10.1038/s41567-025-03166-3</a>
  apa: Yang, B., Zhuang, Y., Yalniz, G., Vasudevan, M., Marensi, E., &#38; Hof, B.
    (2026). Discontinuous transition to shear flow turbulence. <i>Nature Physics</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41567-025-03166-3">https://doi.org/10.1038/s41567-025-03166-3</a>
  chicago: Yang, Bowen, Yi Zhuang, Gökhan Yalniz, Mukund Vasudevan, Elena Marensi,
    and Björn Hof. “Discontinuous Transition to Shear Flow Turbulence.” <i>Nature
    Physics</i>. Springer Nature, 2026. <a href="https://doi.org/10.1038/s41567-025-03166-3">https://doi.org/10.1038/s41567-025-03166-3</a>.
  ieee: B. Yang, Y. Zhuang, G. Yalniz, M. Vasudevan, E. Marensi, and B. Hof, “Discontinuous
    transition to shear flow turbulence,” <i>Nature Physics</i>. Springer Nature,
    2026.
  ista: Yang B, Zhuang Y, Yalniz G, Vasudevan M, Marensi E, Hof B. 2026. Discontinuous
    transition to shear flow turbulence. Nature Physics.
  mla: Yang, Bowen, et al. “Discontinuous Transition to Shear Flow Turbulence.” <i>Nature
    Physics</i>, Springer Nature, 2026, doi:<a href="https://doi.org/10.1038/s41567-025-03166-3">10.1038/s41567-025-03166-3</a>.
  short: B. Yang, Y. Zhuang, G. Yalniz, M. Vasudevan, E. Marensi, B. Hof, Nature Physics
    (2026).
corr_author: '1'
date_created: 2026-02-17T11:38:41Z
date_published: 2026-02-17T00:00:00Z
date_updated: 2026-02-23T11:36:46Z
day: '17'
ddc:
- '532'
department:
- _id: GradSch
- _id: BjHo
doi: 10.1038/s41567-025-03166-3
external_id:
  arxiv:
  - '2311.11474'
has_accepted_license: '1'
language:
- iso: eng
month: '02'
oa_version: Published Version
project:
- _id: 238598C6-32DE-11EA-91FC-C7463DDC885E
  grant_number: '662960'
  name: Revisiting the Turbulence Problem Using Statistical Mechanics
publication: Nature Physics
publication_identifier:
  eissn:
  - 1745-2481
  issn:
  - 1745-2473
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Discontinuous transition to shear flow turbulence
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21311'
abstract:
- lang: eng
  text: 'Air pollution is a critical public health issue worldwide, South America
    faces unique challenges due to rapid urban growth, industrial expansion, and recurrent
    biomass burning. Existing studies have largely focused on regional or national
    scales, overlooking detailed spatio-temporal dynamics in cities. This study provides
    a comprehensive assessment of air pollution spatio-temporal trends from 2013 to
    2023 in six major South American cities: Bogotá, Buenos Aires, Montevideo, Quito,
    Santiago de Chile, and São Paulo. We evaluated four key pollutants, NO2, O3, PM10,
    and PM2.5, using in situ monitoring networks complemented with reanalysis (boundary
    layer and pollution dynamics), and fire detections datasets (biomass burning).
    A key innovation is the use of a Lagrangian Tracker, which identifies persistent
    hotspots and transport pathways of pollutants, offering new insights into transboundary
    pollution. Results show that nearly all cities experienced reductions in particulate
    matter concentrations, while three of the six cities exhibited rising O3 levels,
    reflecting complex interactions between emissions, meteorology, and atmospheric
    chemistry. Santiago de Chile recorded the highest levels of NO2 and PM, strongly
    influenced by topography and biomass burning in JJA. Bogotá and Quito were notably
    impacted by regional fire emissions, whereas coastal cities such as Buenos Aires
    and Montevideo benefited from greater pollutant dispersion but still exceeded
    the World Health Organization guidelines. By integrating ground-based, satellite,
    and reanalysis data with advanced trajectory modeling, this research provides
    detailed spatio-temporal evaluations of air pollution in South America and highlights
    the urgent need for coordinated regional strategies to reduce health and economic
    burdens.'
acknowledgement: 'The author would like to thank Fundación Universitaria Los Libertadores
  (Project ID: ING-40-25) for supporting her in this work. And EALB, would like to
  thank Universidad Sergio Arboleda (Project ID: IN.BG.086.24.015) for supporting
  her in this work. Open access funding provided by Institute of Science and Technology
  (IST Austria). The first author was funded by the Fundacion Universitaria Los Libertadores
  (Project ID: ING-40-25). This project has received funding from the European Union’s
  Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie
  grant agreement No 101034413289 awarded to AC. EALB was supported by Universidad
  Sergio Arboleda (Project ID: IN.BG.086.24.015).'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Yuri
  full_name: González, Yuri
  last_name: González
- first_name: Nicolás
  full_name: Malagón, Nicolás
  last_name: Malagón
- first_name: Kevin
  full_name: Benavides, Kevin
  last_name: Benavides
- first_name: Luis Carlos
  full_name: Belalcázar, Luis Carlos
  last_name: Belalcázar
- first_name: Ellie Anne
  full_name: Lopez-Barrera, Ellie Anne
  last_name: Lopez-Barrera
- first_name: Alejandro
  full_name: Casallas Garcia, Alejandro
  id: 92081129-2d75-11ef-a48d-b04dd7a2385a
  last_name: Casallas Garcia
  orcid: 0000-0002-1988-5035
citation:
  ama: González Y, Malagón N, Benavides K, Belalcázar LC, Lopez-Barrera EA, Casallas
    Garcia A. Spatio-temporal trends of air pollution in six South American cities.
    <i>Earth Systems and Environment</i>. 2026. doi:<a href="https://doi.org/10.1007/s41748-026-01068-9">10.1007/s41748-026-01068-9</a>
  apa: González, Y., Malagón, N., Benavides, K., Belalcázar, L. C., Lopez-Barrera,
    E. A., &#38; Casallas Garcia, A. (2026). Spatio-temporal trends of air pollution
    in six South American cities. <i>Earth Systems and Environment</i>. Springer Nature.
    <a href="https://doi.org/10.1007/s41748-026-01068-9">https://doi.org/10.1007/s41748-026-01068-9</a>
  chicago: González, Yuri, Nicolás Malagón, Kevin Benavides, Luis Carlos Belalcázar,
    Ellie Anne Lopez-Barrera, and Alejandro Casallas Garcia. “Spatio-Temporal Trends
    of Air Pollution in Six South American Cities.” <i>Earth Systems and Environment</i>.
    Springer Nature, 2026. <a href="https://doi.org/10.1007/s41748-026-01068-9">https://doi.org/10.1007/s41748-026-01068-9</a>.
  ieee: Y. González, N. Malagón, K. Benavides, L. C. Belalcázar, E. A. Lopez-Barrera,
    and A. Casallas Garcia, “Spatio-temporal trends of air pollution in six South
    American cities,” <i>Earth Systems and Environment</i>. Springer Nature, 2026.
  ista: González Y, Malagón N, Benavides K, Belalcázar LC, Lopez-Barrera EA, Casallas
    Garcia A. 2026. Spatio-temporal trends of air pollution in six South American
    cities. Earth Systems and Environment.
  mla: González, Yuri, et al. “Spatio-Temporal Trends of Air Pollution in Six South
    American Cities.” <i>Earth Systems and Environment</i>, Springer Nature, 2026,
    doi:<a href="https://doi.org/10.1007/s41748-026-01068-9">10.1007/s41748-026-01068-9</a>.
  short: Y. González, N. Malagón, K. Benavides, L.C. Belalcázar, E.A. Lopez-Barrera,
    A. Casallas Garcia, Earth Systems and Environment (2026).
corr_author: '1'
date_created: 2026-02-18T07:11:14Z
date_published: 2026-02-17T00:00:00Z
date_updated: 2026-02-23T11:57:21Z
day: '17'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1007/s41748-026-01068-9
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1007/s41748-026-01068-9
month: '02'
oa: 1
oa_version: Published Version
publication: Earth Systems and Environment
publication_identifier:
  eissn:
  - 2509-9434
  issn:
  - 2509-9426
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Spatio-temporal trends of air pollution in six South American cities
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21340'
abstract:
- lang: eng
  text: Equilibrium quantum systems are often described by a gas of weakly interacting
    normal modes. Bringing such systems far from equilibrium, however, can drastically
    enhance mode-to-mode interactions. Understanding the resulting liquid is a fundamental
    question for quantum statistical mechanics and a practical question for engineering
    driven quantum devices. To tackle this question, we probe the non-equilibrium
    kinetics of one-dimensional plasmons in a long chain of Josephson junctions. We
    introduce multimode spectroscopy to controllably study the departure from equilibrium,
    witnessing the evolution from pairwise coupling between plasma modes at weak driving
    to dramatic, high-order, cascaded couplings at strong driving. Scaling to many-mode
    drives, we stimulate interactions between hundreds of modes, resulting in near-continuum
    internal dynamics. Imaging the resulting non-equilibrium plasmon populations,
    we then resolve the nonlocal redistribution of energy in the response to a weak
    perturbation—an explicit verification of the emergence of a strongly interacting,
    non-equilibrium liquid of plasmons.
acknowledged_ssus:
- _id: NanoFab
- _id: M-Shop
acknowledgement: We thank V. Vitelli, M. Fruchart, and A. Burshstein for helpful input.
  We acknowledge technical support from the Nanofabrication Facility and the MIBA
  machine shop at IST Austria. This research was supported in part by grant NSF PHY-2309135
  to the Kavli Institute for Theoretical Physics (KITP), by the Austrian Science Fund
  (FWF) SFB F86, and by the NOMIS foundation.
article_number: eady7222
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Anton
  full_name: Bubis, Anton
  id: 1f6212b5-f795-11ec-9c0c-de4780302890
  last_name: Bubis
- first_name: Lucia
  full_name: Vigliotti, Lucia
  id: 539e1e1a-e604-11ee-a1df-f02b018e5c8c
  last_name: Vigliotti
- first_name: Maksym
  full_name: Serbyn, Maksym
  id: 47809E7E-F248-11E8-B48F-1D18A9856A87
  last_name: Serbyn
  orcid: 0000-0002-2399-5827
- first_name: Andrew P
  full_name: Higginbotham, Andrew P
  id: 4AD6785A-F248-11E8-B48F-1D18A9856A87
  last_name: Higginbotham
  orcid: 0000-0003-2607-2363
citation:
  ama: Bubis A, Vigliotti L, Serbyn M, Higginbotham AP. Non-equilibrium plasmon liquid
    in a Josephson junction chain. <i>Science Advances</i>. 2026;12(7). doi:<a href="https://doi.org/10.1126/sciadv.ady7222">10.1126/sciadv.ady7222</a>
  apa: Bubis, A., Vigliotti, L., Serbyn, M., &#38; Higginbotham, A. P. (2026). Non-equilibrium
    plasmon liquid in a Josephson junction chain. <i>Science Advances</i>. American
    Association for the Advancement of Science. <a href="https://doi.org/10.1126/sciadv.ady7222">https://doi.org/10.1126/sciadv.ady7222</a>
  chicago: Bubis, Anton, Lucia Vigliotti, Maksym Serbyn, and Andrew P Higginbotham.
    “Non-Equilibrium Plasmon Liquid in a Josephson Junction Chain.” <i>Science Advances</i>.
    American Association for the Advancement of Science, 2026. <a href="https://doi.org/10.1126/sciadv.ady7222">https://doi.org/10.1126/sciadv.ady7222</a>.
  ieee: A. Bubis, L. Vigliotti, M. Serbyn, and A. P. Higginbotham, “Non-equilibrium
    plasmon liquid in a Josephson junction chain,” <i>Science Advances</i>, vol. 12,
    no. 7. American Association for the Advancement of Science, 2026.
  ista: Bubis A, Vigliotti L, Serbyn M, Higginbotham AP. 2026. Non-equilibrium plasmon
    liquid in a Josephson junction chain. Science Advances. 12(7), eady7222.
  mla: Bubis, Anton, et al. “Non-Equilibrium Plasmon Liquid in a Josephson Junction
    Chain.” <i>Science Advances</i>, vol. 12, no. 7, eady7222, American Association
    for the Advancement of Science, 2026, doi:<a href="https://doi.org/10.1126/sciadv.ady7222">10.1126/sciadv.ady7222</a>.
  short: A. Bubis, L. Vigliotti, M. Serbyn, A.P. Higginbotham, Science Advances 12
    (2026).
corr_author: '1'
date_created: 2026-02-22T20:47:38Z
date_published: 2026-02-13T00:00:00Z
date_updated: 2026-02-24T07:25:34Z
day: '13'
ddc:
- '530'
department:
- _id: MaSe
- _id: AnHi
- _id: GeKa
doi: 10.1126/sciadv.ady7222
external_id:
  arxiv:
  - '2504.09721'
file:
- access_level: open_access
  checksum: 8402f322f8f0e858b1d9aac57e306e31
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-24T07:23:32Z
  date_updated: 2026-02-24T07:23:32Z
  file_id: '21353'
  file_name: 2026_ScienceAdv_Bubis.pdf
  file_size: 2775975
  relation: main_file
  success: 1
file_date_updated: 2026-02-24T07:23:32Z
has_accepted_license: '1'
intvolume: '        12'
issue: '7'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
publication: Science Advances
publication_identifier:
  eissn:
  - 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
status: public
title: Non-equilibrium plasmon liquid in a Josephson junction chain
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: diamond
PlanS_conform: '1'
_id: '21341'
abstract:
- lang: eng
  text: We aim to characterise the mass-metallicity relation (MZR) and the 3D correlation
    between the stellar mass, metallicity, and star formation rate (SFR) known as
    the fundamental metallicity relation (FMR) for galaxies at 5 < z < 7. Using ∼800
    [O III] selected galaxies from deep NIRCam grism surveys, we present our stacked
    measurements of direct-Te metallicities, which we used to test recent strong-line
    metallicity calibrations. Our measured direct-Te metallicities (0.1–0.2 Z⊙ for
    M★ ≈ 5 × 107 − 9 M⊙, respectively) match recent JWST/NIRSpec-based results. However,
    there are significant inconsistencies between observations and hydrodynamical
    simulations. We observe a flatter MZR slope than the SPHINX20 and FLARES simulations,
    which cannot be attributed to selection effects. With simple models, we show that
    the effect of an [O III] flux-limited sample on the observed shape of the MZR
    is strongly dependent on the FMR. If the FMR is similar to the one in the local
    Universe, the intrinsic high-redshift MZR should be even flatter than is observed.
    In turn, a 3D relation where SFR correlates positively with metallicity at fixed
    mass would imply an intrinsically steeper MZR. Our measurements indicate that
    metallicity variations at fixed mass show little dependence on the SFR, suggesting
    a flat intrinsic MZR. This could indicate that the low-mass galaxies at these
    redshifts are out of equilibrium and that metal enrichment occurs rapidly in low-mass
    galaxies. However, being limited by our stacking analysis, we are yet to probe
    the scatter in the MZR and its dependence on SFR. Large carefully selected samples
    of galaxies with robust metallicity measurements can put tight constraints on
    the high-redshift FMR and help us to understand the interplay between gas flows,
    star formation, and feedback in early galaxies.
acknowledgement: 'We thank the anonymous referee for the insightful comments that
  helped improving this paper. This work is based on observations made with the NASA/ESA/CSA
  James Webb Space Telescope. The data were obtained from the Mikulski Archive for
  Space Telescopes at the Space Telescope Science Institute, which is operated by
  the Associations of Universities for Research in Astronomy, Inc., under NASA contract
  NAS 5-03127 for JWST. These observations were taken under programmes # 1243, # 1933
  and # 3516. Funded by the European Union (ERC, AGENTS, 101076224). Views and opinions
  expressed are however those of the author(s) only and do not necessarily reflect
  those of the European Union or the European Research Council. Neither the European
  Union nor the granting authority can be held responsible for them. GK acknowledges
  support from the Foundation MERAC. APV acknowledge support from the Sussex Astronomy
  Centre STFC Consolidated Grant (ST/X001040/1).'
article_number: A165
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Gauri
  full_name: Kotiwale, Gauri
  id: 1438afc8-1ff6-11ee-9fa6-cd4a75d66875
  last_name: Kotiwale
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
- first_name: Daichi
  full_name: Kashino, Daichi
  last_name: Kashino
- first_name: Aswin P.
  full_name: Vijayan, Aswin P.
  last_name: Vijayan
- first_name: Alberto
  full_name: Torralba Torregrosa, Alberto
  id: 018f0249-0e87-11f0-b167-cbce08fbd541
  last_name: Torralba Torregrosa
  orcid: 0000-0001-5586-6950
- first_name: Claudia
  full_name: Di Cesare, Claudia
  id: 2d002343-372f-11ef-98ec-a164d20427cb
  last_name: Di Cesare
- first_name: Edoardo
  full_name: Iani, Edoardo
  id: 4053390a-6b68-11ef-9828-a3b8adef8d0a
  last_name: Iani
  orcid: 0000-0001-8386-3546
- first_name: Rongmon
  full_name: Bordoloi, Rongmon
  last_name: Bordoloi
- first_name: Joel
  full_name: Leja, Joel
  last_name: Leja
- first_name: Michael V.
  full_name: Maseda, Michael V.
  last_name: Maseda
- first_name: Sandro
  full_name: Tacchella, Sandro
  last_name: Tacchella
- first_name: Irene
  full_name: Shivaei, Irene
  last_name: Shivaei
- first_name: Kasper E.
  full_name: Heintz, Kasper E.
  last_name: Heintz
- first_name: A. Lola
  full_name: Danhaive, A. Lola
  last_name: Danhaive
- first_name: Sara
  full_name: Mascia, Sara
  id: edaf889c-c7cd-11ef-ab1b-bb28c431bd29
  last_name: Mascia
- first_name: Ivan
  full_name: Kramarenko, Ivan
  id: 9a9394cb-3200-11ee-973b-f5ba2a8b16e4
  last_name: Kramarenko
  orcid: 0000-0001-5346-6048
- first_name: Benjamín
  full_name: Navarrete, Benjamín
  id: aa14a535-50c9-11ef-b52e-e0c373d10148
  last_name: Navarrete
- first_name: Ruari
  full_name: Mackenzie, Ruari
  last_name: Mackenzie
- first_name: Rohan P.
  full_name: Naidu, Rohan P.
  last_name: Naidu
- first_name: David
  full_name: Sobral, David
  last_name: Sobral
citation:
  ama: Kotiwale G, Matthee JJ, Kashino D, et al. Rapid, out-of-equilibrium metal enrichment
    indicated by a flat mass-metallicity relation at z ∼ 6 from NIRCam grism spectroscopy.
    <i>Astronomy &#38; Astrophysics</i>. 2026;706. doi:<a href="https://doi.org/10.1051/0004-6361/202556597">10.1051/0004-6361/202556597</a>
  apa: Kotiwale, G., Matthee, J. J., Kashino, D., Vijayan, A. P., Torralba Torregrosa,
    A., Di Cesare, C., … Sobral, D. (2026). Rapid, out-of-equilibrium metal enrichment
    indicated by a flat mass-metallicity relation at z ∼ 6 from NIRCam grism spectroscopy.
    <i>Astronomy &#38; Astrophysics</i>. EDP Sciences. <a href="https://doi.org/10.1051/0004-6361/202556597">https://doi.org/10.1051/0004-6361/202556597</a>
  chicago: Kotiwale, Gauri, Jorryt J Matthee, Daichi Kashino, Aswin P. Vijayan, Alberto
    Torralba Torregrosa, Claudia Di Cesare, Edoardo Iani, et al. “Rapid, out-of-Equilibrium
    Metal Enrichment Indicated by a Flat Mass-Metallicity Relation at z ∼ 6 from NIRCam
    Grism Spectroscopy.” <i>Astronomy &#38; Astrophysics</i>. EDP Sciences, 2026.
    <a href="https://doi.org/10.1051/0004-6361/202556597">https://doi.org/10.1051/0004-6361/202556597</a>.
  ieee: G. Kotiwale <i>et al.</i>, “Rapid, out-of-equilibrium metal enrichment indicated
    by a flat mass-metallicity relation at z ∼ 6 from NIRCam grism spectroscopy,”
    <i>Astronomy &#38; Astrophysics</i>, vol. 706. EDP Sciences, 2026.
  ista: Kotiwale G, Matthee JJ, Kashino D, Vijayan AP, Torralba Torregrosa A, Di Cesare
    C, Iani E, Bordoloi R, Leja J, Maseda MV, Tacchella S, Shivaei I, Heintz KE, Danhaive
    AL, Mascia S, Kramarenko I, Navarrete B, Mackenzie R, Naidu RP, Sobral D. 2026.
    Rapid, out-of-equilibrium metal enrichment indicated by a flat mass-metallicity
    relation at z ∼ 6 from NIRCam grism spectroscopy. Astronomy &#38; Astrophysics.
    706, A165.
  mla: Kotiwale, Gauri, et al. “Rapid, out-of-Equilibrium Metal Enrichment Indicated
    by a Flat Mass-Metallicity Relation at z ∼ 6 from NIRCam Grism Spectroscopy.”
    <i>Astronomy &#38; Astrophysics</i>, vol. 706, A165, EDP Sciences, 2026, doi:<a
    href="https://doi.org/10.1051/0004-6361/202556597">10.1051/0004-6361/202556597</a>.
  short: G. Kotiwale, J.J. Matthee, D. Kashino, A.P. Vijayan, A. Torralba Torregrosa,
    C. Di Cesare, E. Iani, R. Bordoloi, J. Leja, M.V. Maseda, S. Tacchella, I. Shivaei,
    K.E. Heintz, A.L. Danhaive, S. Mascia, I. Kramarenko, B. Navarrete, R. Mackenzie,
    R.P. Naidu, D. Sobral, Astronomy &#38; Astrophysics 706 (2026).
corr_author: '1'
date_created: 2026-02-22T23:01:35Z
date_published: 2026-02-01T00:00:00Z
date_updated: 2026-02-24T07:49:42Z
day: '01'
ddc:
- '520'
department:
- _id: JoMa
- _id: GradSch
doi: 10.1051/0004-6361/202556597
external_id:
  arxiv:
  - '2510.19959'
file:
- access_level: open_access
  checksum: 6f5849d29ad43bee32f90152f6fc0294
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-24T07:46:47Z
  date_updated: 2026-02-24T07:46:47Z
  file_id: '21355'
  file_name: 2026_AstronomyAstrophysics_Kotiwale.pdf
  file_size: 6531719
  relation: main_file
  success: 1
file_date_updated: 2026-02-24T07:46:47Z
has_accepted_license: '1'
intvolume: '       706'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: bd9b2118-d553-11ed-ba76-db24564edfea
  grant_number: '101076224'
  name: Young galaxies as tracers and agents of cosmic reionization
publication: Astronomy & Astrophysics
publication_identifier:
  eissn:
  - 1432-0746
  issn:
  - 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Rapid, out-of-equilibrium metal enrichment indicated by a flat mass-metallicity
  relation at z ∼ 6 from NIRCam grism spectroscopy
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 706
year: '2026'
...
---
OA_place: publisher
OA_type: diamond
PlanS_conform: '1'
_id: '21342'
abstract:
- lang: eng
  text: "JWST has revealed a stunning population of bright galaxies at surprisingly
    early epochs, z > 10,\r\nwhere few such sources were expected. Here we present
    the most distant example of this class yet – MoM-z14, a luminous (MUV = −20.2)
    source in the COSMOS legacy field at zspec = 14.44+0.02−0.02 that expands the
    observational frontier to a mere 280 million years after the Big Bang. The redshift
    is confirmed with NIRSpec/prism spectroscopy through a sharp Lyman-α break and
    ≈ 3σ detections of five rest-UV emission lines. The number density of bright zspec
    ≈ 14 − 15 sources implied by our “Mirage or Miracle” survey spanning ≈ 350 arcmin2
    is > 100× larger (182+329 −105×) than pre-JWST consensus models. The high EWs
    of UV lines (≈15−35˚A) signal a rising star-formation history, with a ≈10× increase
    in the last 5 Myr (SFR5Myr/SFR50Myr = 9.9 +3.0 −5.8). The source is extremely
    compact (circularized re = 74+15\r\n−12 pc), and yet elongated (b/a = 0.25+0.11−0.06),
    suggesting an AGN is not the dominant source of UV light. The steep UV slope (β
    = −2.5 +0.2 −0.2) implies negligible dust attenuation\r\nand a young stellar population.
    The absence of a strong damping wing provides tentative evidence that the immediate
    surroundings of MoM-z14 may be partially ionized at a redshift where virtually
    every reionization model predicts a ≈ 100% neutral fraction. The nitrogen emission
    and highly supersolar [N/C]> 1 hint at an abundance pattern similar to local globular
    clusters that may have once hosted luminous supermassive stars. Since this abundance
    pattern is also common among the most ancient stars born in the Milky Way, we
    may be directly witnessing the formation of such stars in dense clusters, connecting
    galaxy evolution across the entire sweep of cosmic time. "
acknowledgement: "We thank the two anonymous referees for their insightful comments
  that have strengthened this work. “Mirage or Miracle” is but the latest link in
  a long chain of surveys that have built COSMOS into a premier extragalactic legacy
  field. We are thankful to all the teams who have contributed to this legacy, particularly
  those mentioned in §3 for leading recent JWST programs whose imaging\r\nwe have
  incorporated in our analysis. We are grateful to Vasily Belokurov for help in compiling
  the Milky Way reference sample featured in Fig 8. We thank Danielle Berg for sharing
  a highly complete, highly decimalized NUV vacuum line list. We are grateful to our
  program’s NIRSpec reviewer, Dan Coe, and program coordinator, Allison Vick, for
  valuable input on our MSA design. We acknowledge illuminating conversations with
  Risa Wechsler and Chao-Lin Kuo about early reionization. RPN thanks Neil Pappalardo
  and Jane Pappalardo for their generous support of the MIT Pappalardo Fellowships
  in Physics, and for their enthusiasm and encouragement for seeking galaxies at the
  highest redshifts. RPN acknowledges funding from JWST program GO5224. Support for
  this work was provided by NASA through the NASA Hubble Fellowship grant HST-HF2-51515.001-A
  awarded by the Space Telescope Science Institute, which is operated by the Association
  of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-26555.
  This work has received funding from the Swiss State Secretariat for Education, Research
  and Innovation (SERI) under contract number MB22.00072, as well as from the Swiss
  National Science Foundation (SNSF) through project grant 200020 207349. Funded by
  the European Union (ERC, AGENTS, 101076224 and HEAVYMETAL, 101071865). Views and
  opinions expressed are however those of the author(s) only and do not necessarily
  reflect those of\r\nthe European Union or the European Research Council. Neither
  the European Union nor the granting authority can be held responsible for them.
  The Cosmic Dawn Center (DAWN) is funded by the Danish National Research Foundation
  under grant DNRF140. This work has also been supported by JSPS KAKENHI Grant Number
  23H00131. HA acknowledges support from CNES, focused on the JWST mission, and the
  Programme National Cosmology and Galaxies (PNCG)\r\nof CNRS/INSU with INP and IN2P3,
  co-funded by CEA and CNES. HA is supported by the French National Research Agency
  (ANR) under the project FIRSTGAL, grant number ANR-24-CE31-0838. SB is supported
  by the UK Research and Innovation (UKRI) Future Leaders Fellowship [grant number
  MR/V023381/1]. R.D. acknowledges support from the INAF GO 2022\r\ngrant “The birth
  of the giants: JWST sheds light on the build-up of quasars at cosmic dawn” and by
  the PRIN MUR “2022935STW”, RFF M4.C2.1.1, CUP J53D23001570006 and C53D23000950006.
  Computations supporting this paper were run on MIT’s Engaging cluster. This publication
  made use of the NASA Astrophysical Data System for bibliographic information. Some
  of the data products presented herein were retrieved from the Dawn JWST Archive
  (DJA). DJA is an initiative of the Cosmic Dawn Center (DAWN), which is funded by
  the Danish National Research Foundation under grant DNRF140. Software used in developing
  this work includes: matplotlib (Hunter 2007), jupyter (Kluyver et al. 2016), IPython
  (P´erez & Granger 2007), numpy (Oliphant 2015), scipy (Virtanen et al. 2020), TOPCAT
  (Taylor 2005), and Astropy (Astropy Collaboration et al. 2013).This work is based
  on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data
  were obtained from the Mikulski Archive for Space\r\nTelescopes at the Space Telescope
  Science Institute, which is operated by the Association of Universities for Research
  in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations
  are associated with program # 5224."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Rohan P.
  full_name: Naidu, Rohan P.
  last_name: Naidu
- first_name: Pascal A.
  full_name: Oesch, Pascal A.
  last_name: Oesch
- first_name: Gabriel
  full_name: Brammer, Gabriel
  last_name: Brammer
- first_name: Andrea
  full_name: Weibel, Andrea
  last_name: Weibel
- first_name: Yijia
  full_name: Li, Yijia
  last_name: Li
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
- first_name: John
  full_name: Chisholm, John
  last_name: Chisholm
- first_name: Clara L.
  full_name: Pollock, Clara L.
  last_name: Pollock
- first_name: Kasper E.
  full_name: Heintz, Kasper E.
  last_name: Heintz
- first_name: Benjamin D.
  full_name: Johnson, Benjamin D.
  last_name: Johnson
- first_name: Xuejian
  full_name: Shen, Xuejian
  last_name: Shen
- first_name: Raphael E.
  full_name: Hviding, Raphael E.
  last_name: Hviding
- first_name: Joel
  full_name: Leja, Joel
  last_name: Leja
- first_name: Sandro
  full_name: Tacchella, Sandro
  last_name: Tacchella
- first_name: Arpita
  full_name: Ganguly, Arpita
  last_name: Ganguly
- first_name: Callum
  full_name: Witten, Callum
  last_name: Witten
- first_name: Hakim
  full_name: Atek, Hakim
  last_name: Atek
- first_name: Sirio
  full_name: Belli, Sirio
  last_name: Belli
- first_name: Sownak
  full_name: Bose, Sownak
  last_name: Bose
- first_name: Rychard
  full_name: Bouwens, Rychard
  last_name: Bouwens
- first_name: Pratika
  full_name: Dayal, Pratika
  last_name: Dayal
- first_name: Roberto
  full_name: Decarli, Roberto
  last_name: Decarli
- first_name: Anna
  full_name: De Graaff, Anna
  last_name: De Graaff
- first_name: Yoshinobu
  full_name: Fudamoto, Yoshinobu
  last_name: Fudamoto
- first_name: Emma
  full_name: Giovinazzo, Emma
  last_name: Giovinazzo
- first_name: Jenny E.
  full_name: Greene, Jenny E.
  last_name: Greene
- first_name: Garth
  full_name: Illingworth, Garth
  last_name: Illingworth
- first_name: Akio K.
  full_name: Inoue, Akio K.
  last_name: Inoue
- first_name: Sarah G.
  full_name: Kane, Sarah G.
  last_name: Kane
- first_name: Ivo
  full_name: Labbe, Ivo
  last_name: Labbe
- first_name: Ecaterina
  full_name: Leonova, Ecaterina
  last_name: Leonova
- first_name: Rui
  full_name: Marques-Chaves, Rui
  last_name: Marques-Chaves
- first_name: Romain A.
  full_name: Meyer, Romain A.
  last_name: Meyer
- first_name: Erica J.
  full_name: Nelson, Erica J.
  last_name: Nelson
- first_name: Guido
  full_name: Roberts-Borsani, Guido
  last_name: Roberts-Borsani
- first_name: Daniel
  full_name: Schaerer, Daniel
  last_name: Schaerer
- first_name: Robert A.
  full_name: Simcoe, Robert A.
  last_name: Simcoe
- first_name: Mauro
  full_name: Stefanon, Mauro
  last_name: Stefanon
- first_name: Yuma
  full_name: Sugahara, Yuma
  last_name: Sugahara
- first_name: Sune
  full_name: Toft, Sune
  last_name: Toft
- first_name: Arjen
  full_name: Van Der Wel, Arjen
  last_name: Van Der Wel
- first_name: Pieter
  full_name: Van Dokkum, Pieter
  last_name: Van Dokkum
- first_name: Fabian
  full_name: Walter, Fabian
  last_name: Walter
- first_name: Darach
  full_name: Watson, Darach
  last_name: Watson
- first_name: John R.
  full_name: Weaver, John R.
  last_name: Weaver
- first_name: Katherine E.
  full_name: Whitaker, Katherine E.
  last_name: Whitaker
citation:
  ama: 'Naidu RP, Oesch PA, Brammer G, et al. A cosmic miracle: A remarkably luminous
    galaxy at zspec = 14.44 confirmed with JWST. <i>The Open Journal of Astrophysics</i>.
    2026;9. doi:<a href="https://doi.org/10.33232/001c.156033">10.33232/001c.156033</a>'
  apa: 'Naidu, R. P., Oesch, P. A., Brammer, G., Weibel, A., Li, Y., Matthee, J. J.,
    … Whitaker, K. E. (2026). A cosmic miracle: A remarkably luminous galaxy at zspec
    = 14.44 confirmed with JWST. <i>The Open Journal of Astrophysics</i>. Maynooth
    Academic Publishing. <a href="https://doi.org/10.33232/001c.156033">https://doi.org/10.33232/001c.156033</a>'
  chicago: 'Naidu, Rohan P., Pascal A. Oesch, Gabriel Brammer, Andrea Weibel, Yijia
    Li, Jorryt J Matthee, John Chisholm, et al. “A Cosmic Miracle: A Remarkably Luminous
    Galaxy at Zspec = 14.44 Confirmed with JWST.” <i>The Open Journal of Astrophysics</i>.
    Maynooth Academic Publishing, 2026. <a href="https://doi.org/10.33232/001c.156033">https://doi.org/10.33232/001c.156033</a>.'
  ieee: 'R. P. Naidu <i>et al.</i>, “A cosmic miracle: A remarkably luminous galaxy
    at zspec = 14.44 confirmed with JWST,” <i>The Open Journal of Astrophysics</i>,
    vol. 9. Maynooth Academic Publishing, 2026.'
  ista: 'Naidu RP, Oesch PA, Brammer G, Weibel A, Li Y, Matthee JJ, Chisholm J, Pollock
    CL, Heintz KE, Johnson BD, Shen X, Hviding RE, Leja J, Tacchella S, Ganguly A,
    Witten C, Atek H, Belli S, Bose S, Bouwens R, Dayal P, Decarli R, De Graaff A,
    Fudamoto Y, Giovinazzo E, Greene JE, Illingworth G, Inoue AK, Kane SG, Labbe I,
    Leonova E, Marques-Chaves R, Meyer RA, Nelson EJ, Roberts-Borsani G, Schaerer
    D, Simcoe RA, Stefanon M, Sugahara Y, Toft S, Van Der Wel A, Van Dokkum P, Walter
    F, Watson D, Weaver JR, Whitaker KE. 2026. A cosmic miracle: A remarkably luminous
    galaxy at zspec = 14.44 confirmed with JWST. The Open Journal of Astrophysics.
    9.'
  mla: 'Naidu, Rohan P., et al. “A Cosmic Miracle: A Remarkably Luminous Galaxy at
    Zspec = 14.44 Confirmed with JWST.” <i>The Open Journal of Astrophysics</i>, vol.
    9, Maynooth Academic Publishing, 2026, doi:<a href="https://doi.org/10.33232/001c.156033">10.33232/001c.156033</a>.'
  short: R.P. Naidu, P.A. Oesch, G. Brammer, A. Weibel, Y. Li, J.J. Matthee, J. Chisholm,
    C.L. Pollock, K.E. Heintz, B.D. Johnson, X. Shen, R.E. Hviding, J. Leja, S. Tacchella,
    A. Ganguly, C. Witten, H. Atek, S. Belli, S. Bose, R. Bouwens, P. Dayal, R. Decarli,
    A. De Graaff, Y. Fudamoto, E. Giovinazzo, J.E. Greene, G. Illingworth, A.K. Inoue,
    S.G. Kane, I. Labbe, E. Leonova, R. Marques-Chaves, R.A. Meyer, E.J. Nelson, G.
    Roberts-Borsani, D. Schaerer, R.A. Simcoe, M. Stefanon, Y. Sugahara, S. Toft,
    A. Van Der Wel, P. Van Dokkum, F. Walter, D. Watson, J.R. Weaver, K.E. Whitaker,
    The Open Journal of Astrophysics 9 (2026).
date_created: 2026-02-22T23:01:35Z
date_published: 2026-01-30T00:00:00Z
date_updated: 2026-02-24T07:37:17Z
day: '30'
ddc:
- '520'
department:
- _id: JoMa
doi: 10.33232/001c.156033
external_id:
  arxiv:
  - '2505.11263'
has_accepted_license: '1'
intvolume: '         9'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https:/​/​doi.org/​10.33232/​001c.156033
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: bd9b2118-d553-11ed-ba76-db24564edfea
  grant_number: '101076224'
  name: Young galaxies as tracers and agents of cosmic reionization
publication: The Open Journal of Astrophysics
publication_identifier:
  eissn:
  - 2565-6120
publication_status: published
publisher: Maynooth Academic Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'A cosmic miracle: A remarkably luminous galaxy at zspec = 14.44 confirmed
  with JWST'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21344'
abstract:
- lang: eng
  text: Tropospheric ozone has the potential to become an increasingly pressing public
    health issue in Bogotá, Colombia, due to rising concentrations across the city
    driven by complex interactions among emissions, meteorology, and urban structure.
    This study presents a comprehensive spatiotemporal analysis of ozone levels from
    2013 to 2023 and assesses the associated health burden using mortality data from
    the same period. Results reveal a consistent upward trend in ozone concentrations,
    particularly in northern, western, and southern localities, with seasonal peaks
    linked to biomass burning and photochemical conditions. Mortality analysis, based
    on the Global Exposure Mortality Model, estimates that 18.3% of all deaths among
    individuals aged 25 and older are attributable to long-term ozone exposure. The
    highest burdens are found in densely populated and socioeconomically vulnerable
    areas such as Kennedy, Suba, and Ciudad Bolívar, with the elderly being the most
    affected. Building on these findings, we developed a machine learning prediction
    model for ozone using a convolutional merge with a long-short term memory network
    architecture trained on air quality and meteorological variables. The model demonstrated
    strong predictive performance (mean Rho=0.86, RMSE=3.5 μg/m3) across monitoring
    stations (17 with at least 35000 data points), supporting its potential application
    in real-time early warning systems across Bogotá. This integrated approach highlights
    the importance of localized air quality management, combining epidemiological
    assessment with predictive modeling. The findings underscore the urgency of implementing
    region-specific mitigation strategies and improving monitoring infrastructure
    to reduce health risks from ozone exposure in Bogotá’s rapidly growing urban environment.
acknowledgement: EAL-B and CP-R received support from Sergio Arboleda University through
  project No. IN.BG.086.24.014. AC acknowledges support by the European Union’s Horizon
  2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement
  No 101034413. We thank two anonymous reviewers for thein insightful comments that
  largely improve the manuscript. Open access funding provided by Institute of Science
  and Technology (IST Austria). This work was funded by the European Union’s Horizon
  2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement
  No 101034413. The work also received funding from Sergio Arboleda University through
  project No. IN.BG.086.24.014.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Daniela
  full_name: Bustos, Daniela
  last_name: Bustos
- first_name: Diana
  full_name: Garcia, Diana
  last_name: Garcia
- first_name: Nestor Y.
  full_name: Rojas, Nestor Y.
  last_name: Rojas
- first_name: Ellie A.
  full_name: Lopez-Barrera, Ellie A.
  last_name: Lopez-Barrera
- first_name: Carlos
  full_name: Peña-Rincon, Carlos
  last_name: Peña-Rincon
- first_name: Alejandro
  full_name: Casallas Garcia, Alejandro
  id: 92081129-2d75-11ef-a48d-b04dd7a2385a
  last_name: Casallas Garcia
  orcid: 0000-0002-1988-5035
citation:
  ama: 'Bustos D, Garcia D, Rojas NY, Lopez-Barrera EA, Peña-Rincon C, Casallas Garcia
    A. Ozone trends and mortality risk: The growing need for machine learning predictions
    in Bogotá, Colombia. <i>Earth Systems and Environment</i>. 2026. doi:<a href="https://doi.org/10.1007/s41748-026-01052-3">10.1007/s41748-026-01052-3</a>'
  apa: 'Bustos, D., Garcia, D., Rojas, N. Y., Lopez-Barrera, E. A., Peña-Rincon, C.,
    &#38; Casallas Garcia, A. (2026). Ozone trends and mortality risk: The growing
    need for machine learning predictions in Bogotá, Colombia. <i>Earth Systems and
    Environment</i>. Springer Nature. <a href="https://doi.org/10.1007/s41748-026-01052-3">https://doi.org/10.1007/s41748-026-01052-3</a>'
  chicago: 'Bustos, Daniela, Diana Garcia, Nestor Y. Rojas, Ellie A. Lopez-Barrera,
    Carlos Peña-Rincon, and Alejandro Casallas Garcia. “Ozone Trends and Mortality
    Risk: The Growing Need for Machine Learning Predictions in Bogotá, Colombia.”
    <i>Earth Systems and Environment</i>. Springer Nature, 2026. <a href="https://doi.org/10.1007/s41748-026-01052-3">https://doi.org/10.1007/s41748-026-01052-3</a>.'
  ieee: 'D. Bustos, D. Garcia, N. Y. Rojas, E. A. Lopez-Barrera, C. Peña-Rincon, and
    A. Casallas Garcia, “Ozone trends and mortality risk: The growing need for machine
    learning predictions in Bogotá, Colombia,” <i>Earth Systems and Environment</i>.
    Springer Nature, 2026.'
  ista: 'Bustos D, Garcia D, Rojas NY, Lopez-Barrera EA, Peña-Rincon C, Casallas Garcia
    A. 2026. Ozone trends and mortality risk: The growing need for machine learning
    predictions in Bogotá, Colombia. Earth Systems and Environment.'
  mla: 'Bustos, Daniela, et al. “Ozone Trends and Mortality Risk: The Growing Need
    for Machine Learning Predictions in Bogotá, Colombia.” <i>Earth Systems and Environment</i>,
    Springer Nature, 2026, doi:<a href="https://doi.org/10.1007/s41748-026-01052-3">10.1007/s41748-026-01052-3</a>.'
  short: D. Bustos, D. Garcia, N.Y. Rojas, E.A. Lopez-Barrera, C. Peña-Rincon, A.
    Casallas Garcia, Earth Systems and Environment (2026).
corr_author: '1'
date_created: 2026-02-23T08:26:51Z
date_published: 2026-02-20T00:00:00Z
date_updated: 2026-02-24T08:02:58Z
day: '20'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1007/s41748-026-01052-3
ec_funded: 1
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1007/s41748-026-01052-3
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
publication: Earth Systems and Environment
publication_identifier:
  eissn:
  - 2509-9434
  issn:
  - 2509-9426
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
status: public
title: 'Ozone trends and mortality risk: The growing need for machine learning predictions
  in Bogotá, Colombia'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: repository
_id: '21360'
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
acknowledgement: "I would like to acknowledge the Austrian Academy of Sciences (ÖAW)
  and European\r\nResearch Executive Agency (REA) for funding my research (DOC ÖAW
  Fellowship\r\n26130, Horizon Europe BOLERO Project 101060393). "
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Stefan
  full_name: Riegler, Stefan
  id: FF6018E0-D806-11E9-8E43-0B14E6697425
  last_name: Riegler
  orcid: 0000-0003-3413-1343
citation:
  ama: 'Riegler S. Root system plasticity under nutrient limitation : Investigating
    hormonal and molecular drivers in Arabidopsis thaliana and Coffea  species. 2026.
    doi:<a href="https://doi.org/10.15479/AT-ISTA-21360">10.15479/AT-ISTA-21360</a>'
  apa: 'Riegler, S. (2026). <i>Root system plasticity under nutrient limitation :
    Investigating hormonal and molecular drivers in Arabidopsis thaliana and Coffea 
    species</i>. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-21360">https://doi.org/10.15479/AT-ISTA-21360</a>'
  chicago: 'Riegler, Stefan. “Root System Plasticity under Nutrient Limitation : Investigating
    Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea  Species.” Institute
    of Science and Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-21360">https://doi.org/10.15479/AT-ISTA-21360</a>.'
  ieee: 'S. Riegler, “Root system plasticity under nutrient limitation : Investigating
    hormonal and molecular drivers in Arabidopsis thaliana and Coffea  species,” Institute
    of Science and Technology Austria, 2026.'
  ista: 'Riegler S. 2026. Root system plasticity under nutrient limitation : Investigating
    hormonal and molecular drivers in Arabidopsis thaliana and Coffea  species. Institute
    of Science and Technology Austria.'
  mla: 'Riegler, Stefan. <i>Root System Plasticity under Nutrient Limitation : Investigating
    Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea  Species</i>.
    Institute of Science and Technology Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-21360">10.15479/AT-ISTA-21360</a>.'
  short: 'S. Riegler, Root System Plasticity under Nutrient Limitation : Investigating
    Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea  Species, Institute
    of Science and Technology Austria, 2026.'
corr_author: '1'
date_created: 2026-02-27T09:08:14Z
date_published: 2026-02-26T00:00:00Z
date_updated: 2026-03-09T12:20:56Z
day: '26'
ddc:
- '570'
- '575'
- '583'
degree_awarded: PhD
department:
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- _id: EvBe
doi: 10.15479/AT-ISTA-21360
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  file_size: 31430022
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  date_created: 2026-03-02T10:59:49Z
  date_updated: 2026-03-02T10:59:49Z
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license: https://creativecommons.org/licenses/by-sa/4.0/
month: '02'
oa_version: Published Version
page: '185'
project:
- _id: 34afa094-11ca-11ed-8bc3-a375845a59fb
  grant_number: '101060393'
  name: Breeding for coffee and cocoa root resilience in low input farming systems
    based on improved rootstocks
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '21363'
    relation: research_data
    status: public
status: public
supervisor:
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
title: 'Root system plasticity under nutrient limitation : Investigating hormonal
  and molecular drivers in Arabidopsis thaliana and Coffea  species'
tmp:
  image: /images/cc_by_sa.png
  legal_code_url: https://creativecommons.org/licenses/by-sa/4.0/legalcode
  name: Creative Commons Attribution-ShareAlike 4.0 International Public License (CC
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  short: CC BY-SA (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2026'
...
---
_id: '21363'
abstract:
- lang: eng
  text: The data contains information on coffee differential gene expression as well
    as co-expression and trait correlations in two separate experiments. First, contrasting
    nitrogen supply, second, intra- and interspecific grafting.
article_processing_charge: No
author:
- first_name: Stefan
  full_name: Riegler, Stefan
  id: FF6018E0-D806-11E9-8E43-0B14E6697425
  last_name: Riegler
  orcid: 0000-0003-3413-1343
citation:
  ama: 'Riegler S. Thesis Data for Root System Plasticity under Nutrient Limitation:
    Investigating Hormonal and Molecular Drivers in Arabidopsis thaliana and Coffea 
    species. 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-21363">10.15479/AT-ISTA-21363</a>'
  apa: 'Riegler, S. (2026). Thesis Data for Root System Plasticity under Nutrient
    Limitation: Investigating Hormonal and Molecular Drivers in Arabidopsis thaliana
    and Coffea  species. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-21363">https://doi.org/10.15479/AT-ISTA-21363</a>'
  chicago: 'Riegler, Stefan. “Thesis Data for Root System Plasticity under Nutrient
    Limitation: Investigating Hormonal and Molecular Drivers in Arabidopsis Thaliana
    and Coffea  Species.” Institute of Science and Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-21363">https://doi.org/10.15479/AT-ISTA-21363</a>.'
  ieee: 'S. Riegler, “Thesis Data for Root System Plasticity under Nutrient Limitation:
    Investigating Hormonal and Molecular Drivers in Arabidopsis thaliana and Coffea 
    species.” Institute of Science and Technology Austria, 2026.'
  ista: 'Riegler S. 2026. Thesis Data for Root System Plasticity under Nutrient Limitation:
    Investigating Hormonal and Molecular Drivers in Arabidopsis thaliana and Coffea 
    species, Institute of Science and Technology Austria, <a href="https://doi.org/10.15479/AT-ISTA-21363">10.15479/AT-ISTA-21363</a>.'
  mla: 'Riegler, Stefan. <i>Thesis Data for Root System Plasticity under Nutrient
    Limitation: Investigating Hormonal and Molecular Drivers in Arabidopsis Thaliana
    and Coffea  Species</i>. Institute of Science and Technology Austria, 2026, doi:<a
    href="https://doi.org/10.15479/AT-ISTA-21363">10.15479/AT-ISTA-21363</a>.'
  short: S. Riegler, (2026).
contributor:
- contributor_type: supervisor
  first_name: Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
corr_author: '1'
date_created: 2026-02-27T09:18:41Z
date_published: 2026-02-27T00:00:00Z
date_updated: 2026-03-09T12:20:56Z
day: '27'
ddc:
- '575'
department:
- _id: GradSch
- _id: EvBe
doi: 10.15479/AT-ISTA-21363
file:
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  date_updated: 2026-02-27T09:11:33Z
  embargo: 2027-02-27
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  relation: main_file
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  date_created: 2026-02-27T09:13:11Z
  date_updated: 2026-02-27T09:13:11Z
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month: '02'
oa_version: None
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '21360'
    relation: used_in_publication
    status: public
status: public
title: 'Thesis Data for Root System Plasticity under Nutrient Limitation: Investigating
  Hormonal and Molecular Drivers in Arabidopsis thaliana and Coffea  species'
tmp:
  image: /images/cc_by_sa.png
  legal_code_url: https://creativecommons.org/licenses/by-sa/4.0/legalcode
  name: Creative Commons Attribution-ShareAlike 4.0 International Public License (CC
    BY-SA 4.0)
  short: CC BY-SA (4.0)
type: research_data
user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21369'
abstract:
- lang: eng
  text: 'Formation of new amyloid fibrils and oligomers from monomeric protein on
    the surfaces of existing fibrils is an important driver of many disorders such
    as Alzheimer’s and Parkinson’s diseases. The structural basis of this secondary
    nucleation process, however, is poorly understood. Here, we ask whether secondary
    nucleation sites are found predominantly at rare growth defects: irregularities
    in the fibril core structure incorporated during their original assembly. We first
    demonstrate using the specific inhibitor of secondary nucleation, Brichos, that
    secondary nucleation sites on Alzheimer’s disease-associated fibrils composed
    of Aβ40 and Aβ42 peptides are rare compared to the number of protein molecules
    they contain. We then grow Aβ40 fibrils under conditions designed to eliminate
    most growth defects while leaving the regular fibril morphology unchanged, and
    confirm the latter using cryo-electron microscopy. We measure both the ability
    of these annealed fibrils to promote secondary nucleation and the stoichiometry
    of their secondary nucleation sites, finding that both are greatly reduced as
    predicted. Re-analysis of published data for other proteins suggests that fibril
    growth defects may also drive secondary nucleation generally across most amyloids.
    These findings could unlock structure-based drug design of therapeutics that aim
    to halt amyloid disorders by inhibiting secondary nucleation sites.'
acknowledgement: This work was supported by the Swedish Research Council (2019-02397
  to E.S., 2015-00143 to S.L., and 2022-06641 to S.L. and E.S.), and the GenerationNano
  project, the European Union’s Horizon 2020 research and innovation programme under
  the Marie Skłodowska-Curie grant agreement No 945378 (S.L. co-PI). We acknowledge
  support from the Wellcome Trust (T.P.J.K.), the Cambridge Centre for Misfolding
  Diseases (T.P.J.K.), the BBSRC (T.P.J.K.), the Frances and Augustus Newman Foundation
  (T.P.J.K.), the ERC PhysProt (agreement n 337969) (T.S., T.P.J.K., S.L.), ETC StG
  “NEPA” (A.Š. and S.C.), the Royal Society (S.C., A.S.), the ERASMUS Programme (T.S.),
  and The Danish Council for Independent Research ∣ Natural Sciences (FNU-11-113326)
  (M.A.). This work was also funded by the Novo Nordisk Foundation (#NNF19OC0054635
  to S.L.), ETH Zürich (T.C.T.M.), and the Swiss National Science Foundation (grant
  no 219703 to A.J.D. and T.C.T.M.). We acknowledge the use of the nano-Characterisation
  and nano-Manufacturing Research Equipment (nCHREM) facility for access to microscopy
  instrumentation. We are grateful to the late Professor Sir Christopher Dobson for
  invaluable conversations regarding the microfluidic diffusional sizing experiments.
  We are also grateful to Quentin A. E. Peter and Thomas Müller for their guidance
  on microfluidic device design. The cuvette-filled icon in Fig. 3d is by Servier
  [https://smart.servier.com/]. It is licensed under CC-BY 3.0 Unported [https://creativecommons.org/licenses/by/3.0/].
  The authors would like to acknowledge Umeå Centre for Electron Microscopy (UCEM)
  for technical assistance and access to electron microscopy. Support was provided
  by SciLifeLab national Cryo-EM Unit at Umeå University.
article_number: '1933'
article_processing_charge: Yes
article_type: original
author:
- first_name: Jing
  full_name: Hu, Jing
  last_name: Hu
- first_name: Tom
  full_name: Scheidt, Tom
  last_name: Scheidt
- first_name: Dev
  full_name: Thacker, Dev
  last_name: Thacker
- first_name: Emil
  full_name: Axell, Emil
  last_name: Axell
- first_name: Elin
  full_name: Stemme, Elin
  last_name: Stemme
- first_name: Urszula
  full_name: Łapińska, Urszula
  last_name: Łapińska
- first_name: Stefan
  full_name: Wennmalm, Stefan
  last_name: Wennmalm
- first_name: Georg
  full_name: Meisl, Georg
  last_name: Meisl
- first_name: Samo
  full_name: Curk, Samo
  id: 031eff0d-d481-11ee-8508-cd12a7a86e5b
  last_name: Curk
  orcid: 0000-0001-6160-9766
- first_name: Maria
  full_name: Andreasen, Maria
  last_name: Andreasen
- first_name: Michele
  full_name: Vendruscolo, Michele
  last_name: Vendruscolo
- first_name: Paolo
  full_name: Arosio, Paolo
  last_name: Arosio
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
- first_name: Jeremy D.
  full_name: Schmit, Jeremy D.
  last_name: Schmit
- first_name: Tuomas P.J.
  full_name: Knowles, Tuomas P.J.
  last_name: Knowles
- first_name: Emma
  full_name: Sparr, Emma
  last_name: Sparr
- first_name: Sara
  full_name: Linse, Sara
  last_name: Linse
- first_name: Thomas C.T.
  full_name: Michaels, Thomas C.T.
  last_name: Michaels
- first_name: Alexander J.
  full_name: Dear, Alexander J.
  last_name: Dear
citation:
  ama: Hu J, Scheidt T, Thacker D, et al. Structural defects in amyloid-β fibrils
    drive secondary nucleation. <i>Nature Communications</i>. 2026;17. doi:<a href="https://doi.org/10.1038/s41467-026-69377-1">10.1038/s41467-026-69377-1</a>
  apa: Hu, J., Scheidt, T., Thacker, D., Axell, E., Stemme, E., Łapińska, U., … Dear,
    A. J. (2026). Structural defects in amyloid-β fibrils drive secondary nucleation.
    <i>Nature Communications</i>. Springer Nature. <a href="https://doi.org/10.1038/s41467-026-69377-1">https://doi.org/10.1038/s41467-026-69377-1</a>
  chicago: Hu, Jing, Tom Scheidt, Dev Thacker, Emil Axell, Elin Stemme, Urszula Łapińska,
    Stefan Wennmalm, et al. “Structural Defects in Amyloid-β Fibrils Drive Secondary
    Nucleation.” <i>Nature Communications</i>. Springer Nature, 2026. <a href="https://doi.org/10.1038/s41467-026-69377-1">https://doi.org/10.1038/s41467-026-69377-1</a>.
  ieee: J. Hu <i>et al.</i>, “Structural defects in amyloid-β fibrils drive secondary
    nucleation,” <i>Nature Communications</i>, vol. 17. Springer Nature, 2026.
  ista: Hu J, Scheidt T, Thacker D, Axell E, Stemme E, Łapińska U, Wennmalm S, Meisl
    G, Curk S, Andreasen M, Vendruscolo M, Arosio P, Šarić A, Schmit JD, Knowles TPJ,
    Sparr E, Linse S, Michaels TCT, Dear AJ. 2026. Structural defects in amyloid-β
    fibrils drive secondary nucleation. Nature Communications. 17, 1933.
  mla: Hu, Jing, et al. “Structural Defects in Amyloid-β Fibrils Drive Secondary Nucleation.”
    <i>Nature Communications</i>, vol. 17, 1933, Springer Nature, 2026, doi:<a href="https://doi.org/10.1038/s41467-026-69377-1">10.1038/s41467-026-69377-1</a>.
  short: J. Hu, T. Scheidt, D. Thacker, E. Axell, E. Stemme, U. Łapińska, S. Wennmalm,
    G. Meisl, S. Curk, M. Andreasen, M. Vendruscolo, P. Arosio, A. Šarić, J.D. Schmit,
    T.P.J. Knowles, E. Sparr, S. Linse, T.C.T. Michaels, A.J. Dear, Nature Communications
    17 (2026).
date_created: 2026-03-01T23:01:38Z
date_published: 2026-02-20T00:00:00Z
date_updated: 2026-03-02T09:36:48Z
day: '20'
ddc:
- '570'
department:
- _id: AnSa
doi: 10.1038/s41467-026-69377-1
ec_funded: 1
external_id:
  pmid:
  - '41708600'
file:
- access_level: open_access
  checksum: fa2b55b3a0d8978de7d2d061c7ad8779
  content_type: application/pdf
  creator: dernst
  date_created: 2026-03-02T09:34:18Z
  date_updated: 2026-03-02T09:34:18Z
  file_id: '21377'
  file_name: 2026_NatureComm_Hu.pdf
  file_size: 4821073
  relation: main_file
  success: 1
file_date_updated: 2026-03-02T09:34:18Z
has_accepted_license: '1'
intvolume: '        17'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
  call_identifier: H2020
  grant_number: '802960'
  name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Structural defects in amyloid-β fibrils drive secondary nucleation
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
OA_type: closed access
_id: '21371'
abstract:
- lang: eng
  text: There may be a newly identified early phase of supermassive black hole growth
acknowledgement: The author acknowledges the support from the European Union (European
  Research Council, AGENTS, 101076224).
article_processing_charge: No
article_type: comment
author:
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
citation:
  ama: Matthee JJ. Black holes disguised as little red dots. <i>Science</i>. 2026;391(6787):767-768.
    doi:<a href="https://doi.org/10.1126/science.adz8603">10.1126/science.adz8603</a>
  apa: Matthee, J. J. (2026). Black holes disguised as little red dots. <i>Science</i>.
    AAAS. <a href="https://doi.org/10.1126/science.adz8603">https://doi.org/10.1126/science.adz8603</a>
  chicago: Matthee, Jorryt J. “Black Holes Disguised as Little Red Dots.” <i>Science</i>.
    AAAS, 2026. <a href="https://doi.org/10.1126/science.adz8603">https://doi.org/10.1126/science.adz8603</a>.
  ieee: J. J. Matthee, “Black holes disguised as little red dots,” <i>Science</i>,
    vol. 391, no. 6787. AAAS, pp. 767–768, 2026.
  ista: Matthee JJ. 2026. Black holes disguised as little red dots. Science. 391(6787),
    767–768.
  mla: Matthee, Jorryt J. “Black Holes Disguised as Little Red Dots.” <i>Science</i>,
    vol. 391, no. 6787, AAAS, 2026, pp. 767–68, doi:<a href="https://doi.org/10.1126/science.adz8603">10.1126/science.adz8603</a>.
  short: J.J. Matthee, Science 391 (2026) 767–768.
corr_author: '1'
date_created: 2026-03-01T23:01:39Z
date_published: 2026-02-19T00:00:00Z
date_updated: 2026-03-02T09:15:45Z
day: '19'
department:
- _id: JoMa
doi: 10.1126/science.adz8603
external_id:
  pmid:
  - '41712710'
intvolume: '       391'
issue: '6787'
language:
- iso: eng
month: '02'
oa_version: None
page: 767-768
pmid: 1
project:
- _id: bd9b2118-d553-11ed-ba76-db24564edfea
  grant_number: '101076224'
  name: Young galaxies as tracers and agents of cosmic reionization
publication: Science
publication_identifier:
  eissn:
  - 1095-9203
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: Black holes disguised as little red dots
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 391
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21373'
abstract:
- lang: eng
  text: Cold atom experiments show that a mobile impurity particle immersed in a weakly
    interacting Bose-Einstein condensate forms a well-defined quasiparticle (Bose
    polaron) for weak to moderate impurity-boson interaction strengths, whereas a
    significant line broadening is consistently observed for strong interactions.
    Motivated by this, we introduce a phenomenological theory based on the assumption
    that the most relevant states are characterized by the impurity correlated with
    at most one boson, since they have the largest overlap with the uncorrelated states
    to which the most common experimental probes couple. These experimentally relevant
    states can, however, decay to lower energy states characterized by correlations
    involving multiple bosons, and we model this using a minimal variational wave
    function combined with a complex impurity-boson interaction strength. We first
    motivate this approach by comparing to a more elaborate theory that includes correlations
    with up to two bosons. Our phenomenological model is shown to recover the main
    results of two recent experiments probing both the spectral and the nonequilibrium
    properties of the Bose polaron. Our work offers an intuitive framework for analyzing
    experimental data and highlights the importance of understanding the complicated
    problem of the Bose polaron decay in a many-body setting.
acknowledgement: We thank Georgios Koutentakis, Frédéric Chevy, Hussam Al Daas, and
  Richard Schmidt for fruitful discussions; Jan Arlt for sharing their experimental
  data and many fruitful discussions; and Christoph Eigen for sharing their experimental
  data and inspiring discussions. R.A., T.P., and G.M.B. have been supported in part
  by the Danish National Research Foundation through the Center of Excellence “CCQ”
  (Grant Agreement No. DNRF156) and the Independent Research Fund Denmark–Natural
  Sciences via Grant No. DFF-8021-00233B. R.A., A.G.V., and M.L. acknowledge support
  by the European Research Council (ERC) Starting Grant No. 801770 (ANGULON). R.A.
  received funding from the Austrian Academy of Science ÖAW Grant No. PR1029OEAW03.
article_number: L012034
article_processing_charge: No
article_type: letter_note
arxiv: 1
author:
- first_name: Ragheed
  full_name: Al Hyder, Ragheed
  id: d1c405be-ae15-11ed-8510-ccf53278162e
  last_name: Al Hyder
- first_name: G. M.
  full_name: Bruun, G. M.
  last_name: Bruun
- first_name: T.
  full_name: Pohl, T.
  last_name: Pohl
- first_name: Mikhail
  full_name: Lemeshko, Mikhail
  id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
  last_name: Lemeshko
  orcid: 0000-0002-6990-7802
- first_name: Artem
  full_name: Volosniev, Artem
  id: 37D278BC-F248-11E8-B48F-1D18A9856A87
  last_name: Volosniev
  orcid: 0000-0003-0393-5525
citation:
  ama: Al Hyder R, Bruun GM, Pohl T, Lemeshko M, Volosniev A. Phenomenological model
    of decaying Bose polarons. <i>Physical Review Research</i>. 2026;8. doi:<a href="https://doi.org/10.1103/16dk-5dgx">10.1103/16dk-5dgx</a>
  apa: Al Hyder, R., Bruun, G. M., Pohl, T., Lemeshko, M., &#38; Volosniev, A. (2026).
    Phenomenological model of decaying Bose polarons. <i>Physical Review Research</i>.
    American Physical Society. <a href="https://doi.org/10.1103/16dk-5dgx">https://doi.org/10.1103/16dk-5dgx</a>
  chicago: Al Hyder, Ragheed, G. M. Bruun, T. Pohl, Mikhail Lemeshko, and Artem Volosniev.
    “Phenomenological Model of Decaying Bose Polarons.” <i>Physical Review Research</i>.
    American Physical Society, 2026. <a href="https://doi.org/10.1103/16dk-5dgx">https://doi.org/10.1103/16dk-5dgx</a>.
  ieee: R. Al Hyder, G. M. Bruun, T. Pohl, M. Lemeshko, and A. Volosniev, “Phenomenological
    model of decaying Bose polarons,” <i>Physical Review Research</i>, vol. 8. American
    Physical Society, 2026.
  ista: Al Hyder R, Bruun GM, Pohl T, Lemeshko M, Volosniev A. 2026. Phenomenological
    model of decaying Bose polarons. Physical Review Research. 8, L012034.
  mla: Al Hyder, Ragheed, et al. “Phenomenological Model of Decaying Bose Polarons.”
    <i>Physical Review Research</i>, vol. 8, L012034, American Physical Society, 2026,
    doi:<a href="https://doi.org/10.1103/16dk-5dgx">10.1103/16dk-5dgx</a>.
  short: R. Al Hyder, G.M. Bruun, T. Pohl, M. Lemeshko, A. Volosniev, Physical Review
    Research 8 (2026).
corr_author: '1'
date_created: 2026-03-01T23:01:39Z
date_published: 2026-02-06T00:00:00Z
date_updated: 2026-03-02T09:27:26Z
day: '06'
ddc:
- '530'
department:
- _id: MiLe
doi: 10.1103/16dk-5dgx
ec_funded: 1
external_id:
  arxiv:
  - '2507.04143'
file:
- access_level: open_access
  checksum: 172720f1f0c5c9d06a282e52023a0030
  content_type: application/pdf
  creator: dernst
  date_created: 2026-03-02T09:24:44Z
  date_updated: 2026-03-02T09:24:44Z
  file_id: '21376'
  file_name: 2026_JPhysPhotonics_Volpe.pdf
  file_size: 16789781
  relation: main_file
  success: 1
file_date_updated: 2026-03-02T09:24:44Z
has_accepted_license: '1'
intvolume: '         8'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: 2688CF98-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '801770'
  name: 'Angulon: physics and applications of a new quasiparticle'
- _id: 8fa7db46-16d5-11f0-9cad-917600954daf
  grant_number: '12078'
  name: Polarons in Lead Halide Perovskites
publication: Physical Review Research
publication_identifier:
  issn:
  - 2643-1564
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Phenomenological model of decaying Bose polarons
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21374'
abstract:
- lang: eng
  text: "Let . S be a set of distinct points in general position in the\r\nEuclidean
    plane. A plane Hamiltonian path on . S is a crossing-free geometric path such
    that every point of .S is a vertex of the path. It is\r\nknown that, if. S is
    sufficiently large, there exist three edge-disjoint plane\r\nHamiltonian paths
    on . S. In this paper we study an edge-constrained\r\nversion of the problem of
    finding Hamiltonian paths on a point set. We\r\nfirst consider the problem of
    finding a single plane Hamiltonian path . π\r\nwith endpoints .s, t ∈ S and constraints
    given by a segment . ab, where\r\n.a, b ∈ S. We consider the following scenarios:
    (i) .ab ∈ π; (ii) .ab π. We\r\ncharacterize those quintuples . S, a, b, s, t for
    which . π exists. Secondly,\r\nwe consider the problem of finding two plane Hamiltonian
    paths . π1, π2\r\non a set . S with constraints given by a segment . ab, where
    .a, b ∈ S. We\r\nconsider the following scenarios: (i) .π1 and .π2 share no edges
    and .ab is\r\nan edge of . π1; (ii) .π1 and .π2 share no edges and none of them
    includes\r\n.ab as an edge; (iii) both .π1 and .π2 include .ab as an edge and
    share no\r\nother edges. In all cases, we characterize those triples . S, a, b
    for which\r\n.π1 and .π2 exist."
acknowledgement: "We thank the organizers of the HOMONOLO 2024 workshop in Nová Louka,
  Czech Republic, for the fruitful atmosphere where the research on this project was
  initiated.\r\n\r\nT. Antić, A. Džuklevski, J. Kratochvíl and M. Saumell received
  funding from GAČR grant 23–04949X, T.A and A.Dž were additionally supported by GAUK
  grant SVV–2025–260822. G. Liotta was supported in part by MUR of Italy, PRIN Project
  no. 2022TS4Y3N – EXPAND and PON Project ARS01_00540. J. Fiala was in part supported
  by GAČR grant 25-16847S."
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Todor
  full_name: Antić, Todor
  last_name: Antić
- first_name: Aleksa
  full_name: Džuklevski, Aleksa
  last_name: Džuklevski
- first_name: Jiří
  full_name: Fiala, Jiří
  last_name: Fiala
- first_name: Jan
  full_name: Kratochvíl, Jan
  last_name: Kratochvíl
- first_name: Giuseppe
  full_name: Liotta, Giuseppe
  last_name: Liotta
- first_name: Morteza
  full_name: Saghafian, Morteza
  id: f86f7148-b140-11ec-9577-95435b8df824
  last_name: Saghafian
- first_name: Maria
  full_name: Saumell, Maria
  last_name: Saumell
- first_name: Johannes
  full_name: Zink, Johannes
  last_name: Zink
citation:
  ama: 'Antić T, Džuklevski A, Fiala J, et al. Edge-constrained Hamiltonian paths
    on a point set. In: <i>51st International Conference on Current Trends in Theory
    and Practice of Computer Science</i>. Vol 16448. Springer Nature; 2026:532-546.
    doi:<a href="https://doi.org/10.1007/978-3-032-17801-5_39">10.1007/978-3-032-17801-5_39</a>'
  apa: 'Antić, T., Džuklevski, A., Fiala, J., Kratochvíl, J., Liotta, G., Saghafian,
    M., … Zink, J. (2026). Edge-constrained Hamiltonian paths on a point set. In <i>51st
    International Conference on Current Trends in Theory and Practice of Computer
    Science</i> (Vol. 16448, pp. 532–546). Krakow, Poland: Springer Nature. <a href="https://doi.org/10.1007/978-3-032-17801-5_39">https://doi.org/10.1007/978-3-032-17801-5_39</a>'
  chicago: Antić, Todor, Aleksa Džuklevski, Jiří Fiala, Jan Kratochvíl, Giuseppe Liotta,
    Morteza Saghafian, Maria Saumell, and Johannes Zink. “Edge-Constrained Hamiltonian
    Paths on a Point Set.” In <i>51st International Conference on Current Trends in
    Theory and Practice of Computer Science</i>, 16448:532–46. Springer Nature, 2026.
    <a href="https://doi.org/10.1007/978-3-032-17801-5_39">https://doi.org/10.1007/978-3-032-17801-5_39</a>.
  ieee: T. Antić <i>et al.</i>, “Edge-constrained Hamiltonian paths on a point set,”
    in <i>51st International Conference on Current Trends in Theory and Practice of
    Computer Science</i>, Krakow, Poland, 2026, vol. 16448, pp. 532–546.
  ista: 'Antić T, Džuklevski A, Fiala J, Kratochvíl J, Liotta G, Saghafian M, Saumell
    M, Zink J. 2026. Edge-constrained Hamiltonian paths on a point set. 51st International
    Conference on Current Trends in Theory and Practice of Computer Science. SOFSEM:
    Conference on Current Trends in Theory and Practice of Computer Science, LNCS,
    vol. 16448, 532–546.'
  mla: Antić, Todor, et al. “Edge-Constrained Hamiltonian Paths on a Point Set.” <i>51st
    International Conference on Current Trends in Theory and Practice of Computer
    Science</i>, vol. 16448, Springer Nature, 2026, pp. 532–46, doi:<a href="https://doi.org/10.1007/978-3-032-17801-5_39">10.1007/978-3-032-17801-5_39</a>.
  short: T. Antić, A. Džuklevski, J. Fiala, J. Kratochvíl, G. Liotta, M. Saghafian,
    M. Saumell, J. Zink, in:, 51st International Conference on Current Trends in Theory
    and Practice of Computer Science, Springer Nature, 2026, pp. 532–546.
conference:
  end_date: 2026-02-13
  location: Krakow, Poland
  name: 'SOFSEM: Conference on Current Trends in Theory and Practice of Computer Science'
  start_date: 2026-02-09
date_created: 2026-03-01T23:01:40Z
date_published: 2026-02-13T00:00:00Z
date_updated: 2026-03-02T08:49:20Z
day: '13'
department:
- _id: HeEd
doi: 10.1007/978-3-032-17801-5_39
external_id:
  arxiv:
  - '2511.22526'
intvolume: '     16448'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2511.22526
month: '02'
oa: 1
oa_version: Preprint
page: 532-546
publication: 51st International Conference on Current Trends in Theory and Practice
  of Computer Science
publication_identifier:
  eissn:
  - 1611-3349
  isbn:
  - '9783032178008'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Edge-constrained Hamiltonian paths on a point set
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16448
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21378'
abstract:
- lang: eng
  text: From insects to mammals, essential brain functions, such as forming long-term
    memories (LTMs), increase metabolic activity in stimulated neurons to meet the
    energetic demand associated with brain activation. However, while impairing neuronal
    metabolism limits brain performance, whether expanding the metabolic capacity
    of neurons boosts brain function remains poorly understood. Here, we show that
    LTM formation of flies and mice can be enhanced by increasing mitochondrial metabolism
    in central memory circuits. By knocking down the mitochondrial Ca2+ exporter Letm1,
    we favour Ca2+ retention in the mitochondrial matrix of neurons due to reduction
    of mitochondrial H+/Ca2+ exchange. The resulting increase in mitochondrial Ca2+
    over-activates mitochondrial metabolism in neurons of central memory circuits,
    leading to improved LTM storage in training paradigms in which wild-type counterparts
    of both species fail to remember. Our findings unveil an evolutionarily conserved
    mechanism that controls mitochondrial metabolism in neurons and indicate its involvement
    in shaping higher brain functions, such as LTM.
acknowledgement: We thank all members of the laboratory of J.d.J.-S. for insightful
  discussions and comments. We thank S. Perez for technical assistance. This work
  was made possible by the Paris Brain Institute Diane Barriere Chair in Synaptic
  Bioenergetics awarded to J.d.J.-S., who is also supported by an ERC Starting Grant
  (SynaptoEnergy, European Research Council; ERC-StG-852873), 2019 ATIP-Avenir Grant
  (CNRS, Inserm), a Big Brain Theory Grant (ICM Foundation) and a Kavli Exploratory
  Award (Kavli Foundation). This work was also supported by an ERC Advanced Grant
  (EnergyMeMo; ERC-AdG-741550) to T.P. and grants from the Agence Nationale de la
  Recherche to P.Y.P. (ANR-20-CE92-0047-01), T.P. (ANR-23-CE16-0029-01), A.P. and
  J.d.J.-S. (ANR-22-CE16-0020) and J.d.J.-S. (ANR-24-CE16-0221). T.P., P.Y.P. and
  J.d.J.-S. are permanent CNRS researchers. A.P. is a permanent ESPCI associate professor.
  T.C. was funded by the French Ministry of Research and the Fondation pour la Recherche
  Médicale. V.R. was funded by the Max Planck Society, the Chan Zuckerberg Initiative
  DAF, an advised fund of the Silicon Valley Community Foundation grant number 2024-349543
  and the NIH Director’s New Innovator Award (DP2 MH140148). A.B.-G. and C.R.-D. received
  funding from an ERC Starting Grant (HighMemory; ERC-StG-948217), the Ministry of
  Economy and Competitiveness (PID2021-122795OB-I00) and the Departament d’Economia
  i Coneixement de la Generalitat de Catalunya (SGR 00022). T.P.V. was funded by the
  Wellcome Trust and a Royal Society Sir Henry Dale Research Fellowship (WT100000)
  and a Wellcome Trust Senior Research Fellowship (214316/Z/18/Z). K.G. was supported
  by the DIM C-BRAINS, funded by the Conseil Régional d’Ile-de-France. The contributions
  of H.F. and E.R.S. were supported by the Howard Hughes Medical Institute. The PHENO-ICMice
  animal Core at ICM is supported by two ‘Investissements d’avenir’ (ANR-10- IAIHU-06
  and ANR-11-INBS-0011-NeurATRIS) and the Fondation pour la Recherche Médicale.
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Anjali
  full_name: Amrapali Vishwanath, Anjali
  last_name: Amrapali Vishwanath
- first_name: Typhaine
  full_name: Comyn, Typhaine
  last_name: Comyn
- first_name: Rodrigo G.
  full_name: Mira, Rodrigo G.
  last_name: Mira
- first_name: Claire
  full_name: Brossier, Claire
  last_name: Brossier
- first_name: Carlos
  full_name: Pascual-Caro, Carlos
  last_name: Pascual-Caro
- first_name: Maya
  full_name: Faour, Maya
  last_name: Faour
- first_name: Kahina
  full_name: Boumendil, Kahina
  last_name: Boumendil
- first_name: Chaitanya
  full_name: Chintaluri, Chaitanya
  id: BA06AFEE-A4BA-11EA-AE5C-14673DDC885E
  last_name: Chintaluri
  orcid: 0000-0003-4252-1608
- first_name: Carla
  full_name: Ramon-Duaso, Carla
  last_name: Ramon-Duaso
- first_name: Ruolin
  full_name: Fan, Ruolin
  last_name: Fan
- first_name: Kishalay
  full_name: Ghosh, Kishalay
  last_name: Ghosh
- first_name: Helen
  full_name: Farrants, Helen
  last_name: Farrants
- first_name: Jean-Paul
  full_name: Berwick, Jean-Paul
  last_name: Berwick
- first_name: Riya
  full_name: Sivakumar, Riya
  last_name: Sivakumar
- first_name: Mario
  full_name: Lopez-Manzaneda, Mario
  last_name: Lopez-Manzaneda
- first_name: Eric R.
  full_name: Schreiter, Eric R.
  last_name: Schreiter
- first_name: Thomas
  full_name: Preat, Thomas
  last_name: Preat
- first_name: Tim P
  full_name: Vogels, Tim P
  id: CB6FF8D2-008F-11EA-8E08-2637E6697425
  last_name: Vogels
  orcid: 0000-0003-3295-6181
- first_name: Vidhya
  full_name: Rangaraju, Vidhya
  last_name: Rangaraju
- first_name: Arnau
  full_name: Busquets-Garcia, Arnau
  last_name: Busquets-Garcia
- first_name: Pierre-Yves
  full_name: Plaçais, Pierre-Yves
  last_name: Plaçais
- first_name: Alice
  full_name: Pavlowsky, Alice
  last_name: Pavlowsky
- first_name: Jaime
  full_name: de Juan-Sanz, Jaime
  last_name: de Juan-Sanz
citation:
  ama: Amrapali Vishwanath A, Comyn T, Mira RG, et al. Mitochondrial Ca2+ efflux controls
    neuronal metabolism and long-term memory across species. <i>Nature Metabolism</i>.
    2026;8(2):467-488. doi:<a href="https://doi.org/10.1038/s42255-026-01451-w">10.1038/s42255-026-01451-w</a>
  apa: Amrapali Vishwanath, A., Comyn, T., Mira, R. G., Brossier, C., Pascual-Caro,
    C., Faour, M., … de Juan-Sanz, J. (2026). Mitochondrial Ca2+ efflux controls neuronal
    metabolism and long-term memory across species. <i>Nature Metabolism</i>. Springer
    Nature. <a href="https://doi.org/10.1038/s42255-026-01451-w">https://doi.org/10.1038/s42255-026-01451-w</a>
  chicago: Amrapali Vishwanath, Anjali, Typhaine Comyn, Rodrigo G. Mira, Claire Brossier,
    Carlos Pascual-Caro, Maya Faour, Kahina Boumendil, et al. “Mitochondrial Ca2+
    Efflux Controls Neuronal Metabolism and Long-Term Memory across Species.” <i>Nature
    Metabolism</i>. Springer Nature, 2026. <a href="https://doi.org/10.1038/s42255-026-01451-w">https://doi.org/10.1038/s42255-026-01451-w</a>.
  ieee: A. Amrapali Vishwanath <i>et al.</i>, “Mitochondrial Ca2+ efflux controls
    neuronal metabolism and long-term memory across species,” <i>Nature Metabolism</i>,
    vol. 8, no. 2. Springer Nature, pp. 467–488, 2026.
  ista: Amrapali Vishwanath A, Comyn T, Mira RG, Brossier C, Pascual-Caro C, Faour
    M, Boumendil K, Chintaluri C, Ramon-Duaso C, Fan R, Ghosh K, Farrants H, Berwick
    J-P, Sivakumar R, Lopez-Manzaneda M, Schreiter ER, Preat T, Vogels TP, Rangaraju
    V, Busquets-Garcia A, Plaçais P-Y, Pavlowsky A, de Juan-Sanz J. 2026. Mitochondrial
    Ca2+ efflux controls neuronal metabolism and long-term memory across species.
    Nature Metabolism. 8(2), 467–488.
  mla: Amrapali Vishwanath, Anjali, et al. “Mitochondrial Ca2+ Efflux Controls Neuronal
    Metabolism and Long-Term Memory across Species.” <i>Nature Metabolism</i>, vol.
    8, no. 2, Springer Nature, 2026, pp. 467–88, doi:<a href="https://doi.org/10.1038/s42255-026-01451-w">10.1038/s42255-026-01451-w</a>.
  short: A. Amrapali Vishwanath, T. Comyn, R.G. Mira, C. Brossier, C. Pascual-Caro,
    M. Faour, K. Boumendil, C. Chintaluri, C. Ramon-Duaso, R. Fan, K. Ghosh, H. Farrants,
    J.-P. Berwick, R. Sivakumar, M. Lopez-Manzaneda, E.R. Schreiter, T. Preat, T.P.
    Vogels, V. Rangaraju, A. Busquets-Garcia, P.-Y. Plaçais, A. Pavlowsky, J. de Juan-Sanz,
    Nature Metabolism 8 (2026) 467–488.
date_created: 2026-03-02T10:04:49Z
date_published: 2026-02-11T00:00:00Z
date_updated: 2026-03-02T15:23:10Z
day: '11'
ddc:
- '570'
department:
- _id: TiVo
doi: 10.1038/s42255-026-01451-w
external_id:
  pmid:
  - '41673453'
file:
- access_level: open_access
  checksum: 365932a599d05bc9ce8a57204e7a1465
  content_type: application/pdf
  creator: dernst
  date_created: 2026-03-02T15:21:27Z
  date_updated: 2026-03-02T15:21:27Z
  file_id: '21392'
  file_name: 2026_NatureMetab_AmrapaliVishwanath.pdf
  file_size: 5326608
  relation: main_file
  success: 1
file_date_updated: 2026-03-02T15:21:27Z
has_accepted_license: '1'
intvolume: '         8'
issue: '2'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 467-488
pmid: 1
project:
- _id: c084a126-5a5b-11eb-8a69-d75314a70a87
  grant_number: 214316/Z/18/Z
  name: What’s in a memory? Spatiotemporal dynamics in strongly coupled recurrent
    neuronal networks.
publication: Nature Metabolism
publication_identifier:
  eissn:
  - 2522-5812
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory
  across species
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2026'
...
