---
OA_place: publisher
_id: '22664'
abstract:
- lang: eng
text: "The widespread adoption of apps like Whatsapp and Signal has translated into
billions of people all around the world communicating on a regular basis by making
use of services that offer end-to-end encryption and even provide security guarantees
when a user's device is compromised.\r\n\r\nThis was made possible by the introduction
of the Double Ratchet Algorithm~\\cite{double_ratchet}, which was designed for
a setting where communication takes place between two parties.\r\nHowever, in
practice, many apps offer the possibility of creating groups.\r\nThe protocols
they use to secure communication are inefficient for large group which has the
undesireable consequence that the aforementioned apps have established limits
on the group size of roughly 1000 users.\r\nThis has motivated the introduction
of the Messaging Layer Security (MLS) standard~\\cite{rfc9420} by the IETF which
is based on a primitive called Continuous Group Key Agreement (CGKA)~\\cite{C:ACDT20}.\r\n\r\nThis
primitive allows a group of users to maintain a shared secret key that is frequently
rotated by the group members in order to change group membership, achieve forward
secrecy (FS) and post compromise security (PCS).\r\nMost protocols are based on
binary trees where the nodes are associated to a pair formed by public key and
a secret key.\r\nEach leaf corresponds to one of the group members and a user
knows the secret keys associated to nodes along the path from their leaf to the
root.\r\nWhen a user wants to update their key material they have to change $
\\log(N) $ many keys.\r\nThis requires uploading $ \\log(N) $ many ciphertexts
to communicate the new keys to the rest of the group members in a way that respects
the tree structure.\r\n\r\nIn this thesis we study how much communication between
group members is required in order to add and remove users from a group as well
as in order to provide PCS when we consider CGKAs built using standard cryptographic
primitives like pseudo-random functions and public-key encryption. Furthermore,
we also consider the case of MLS and provide the first lower bound showing that
its communication complexity is much worse than previously believed, i.e., it
is very far from $ \\log(N) $.\r\nFinally, we also propose a variant of MLS which
provably achieves the same security properties with a much lower communication
cost."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Miguel
full_name: Cueto Noval, Miguel
id: ffc563a3-f6e0-11ea-865d-e3cce03d17cc
last_name: Cueto Noval
orcid: 0000-0002-2505-4246
citation:
ama: Cueto Noval M. Towards efficient secure group messaging. 2026. doi:10.15479/AT-ISTA-22664
apa: Cueto Noval, M. (2026). Towards efficient secure group messaging. Institute
of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-22664
chicago: Cueto Noval, Miguel. “Towards Efficient Secure Group Messaging.” Institute
of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-22664.
ieee: M. Cueto Noval, “Towards efficient secure group messaging,” Institute of Science
and Technology Austria, 2026.
ista: Cueto Noval M. 2026. Towards efficient secure group messaging. Institute of
Science and Technology Austria.
mla: Cueto Noval, Miguel. Towards Efficient Secure Group Messaging. Institute
of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-22664.
short: M. Cueto Noval, Towards Efficient Secure Group Messaging, Institute of Science
and Technology Austria, 2026.
corr_author: '1'
date_created: 2026-08-10T10:18:35Z
date_published: 2026-08-10T00:00:00Z
date_updated: 2026-10-16T10:14:40Z
day: '10'
ddc:
- '000'
degree_awarded: PhD
department:
- _id: GradSch
- _id: KrPi
doi: 10.15479/AT-ISTA-22664
doi_confirm: '1'
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language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '08'
oa: 1
oa_version: Published Version
page: '187'
publication_identifier:
isbn:
- ' 978-3-99078-087-9'
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '21262'
relation: part_of_dissertation
status: public
- id: '14691'
relation: part_of_dissertation
status: public
- id: '18702'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Krzysztof Z
full_name: Pietrzak, Krzysztof Z
id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
last_name: Pietrzak
orcid: 0000-0002-9139-1654
title: Towards efficient secure group messaging
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2026'
...
---
OA_place: publisher
_id: '22857'
abstract:
- lang: eng
text: "Artificial intelligence and machine learning have undergone an unprecedented
evolution in the past decade, motivating a research effort toward a theory able
to capture the qualitative behavior of large-scale neural systems. A central puzzle
has been the clear benefit of scaling architecture size and overfitting the training
set in supervised learning tasks. This evidence, in apparent contradiction with
classical statistical learning theory, pushed researchers to develop a new theory
capturing the interplay between the algorithmic and architectural bias of training
and the specific target function, differently from previous methods rooted in
uniform stability.\r\nThis approach has enabled a grounded understanding of novel
learning regimes, typically through formal limits where the number of training
samples $n$, data dimensions $d$, and model parameters $p$ grow to infinity at
different rates. \\\\\r\nIn this thesis, we follow this approach, focusing on
the trustworthiness of high-dimensional models: properties that are difficult
to control during training or deployment and often emerge under unpredictable
or adversarial conditions. In such settings, it is crucial to formally ensure
a priori the reliability of machine learning systems.\r\nFirst, we study data
memorization, both as label fitting and as the storage of private information
about training samples in trained parameters. We prove that $p = \\Omega(n)$ parameters
are sufficient for a deep neural network to memorize a generic set of labels,
and for a model to memorize spurious features across training data. We then give
evidence that $p = \\Omega(dn)$ parameters are instead necessary for an adversary
to reconstruct the full training set from the trained parameters.\r\nSecond, we
study robustness, both to adversarial perturbations and to distribution shift.
We first prove that $p = \\Omega(dn)$ parameters can be sufficient for a class
of neural networks to overfit the training data while guaranteeing robustness
to adversarial perturbations. Then, we focus on spurious correlations learning
in high-dimensional regression, studying the effect of the ridge regularization
parameter in the proportional regime $n = \\Theta(d)$, and connecting it via an
equivalence argument to the role of over-parameterization $p = \\Omega(n)$ in
neural networks. We also investigate the architectural bias of attention-based
networks, showing that they are sensitive to the replacement of individual words
in an embedded sentence, allowing them to generalize on sentences where the contextual
meaning depends on one or few words.\r\nFinally, we study differentially private
optimization in high-dimensional regimes. We prove that standard private gradient
methods do not suffer in the over-parameterized regime $p = \\Omega(n)$, challenging
the current wisdom based on stability-derived generalization bounds. We then consider
linear regression in the proportional regime $n = \\Theta(d)$, showing that standard
private gradient descent can achieve optimal rates under appropriate hyper-parameter
scaling, such as sufficiently small gradient clipping constants, whose role is
still debated in practice."
acknowledged_ssus:
- _id: ScienComp
acknowledgement: "This project was partially supported by the 2019 Lopez-Loreta prize,\r\nthe
European Union (ERC, INF2\r\n, project number 101161364), the Austrian Science Fund\r\n(FWF)
10.55776/COE12, and a Google PhD fellowship in machine intelligence. Furthermore,\r\nthe
candidate acknowledges the support from the Scientific Service Units of the Institute
of\r\nScience and Technology Austria through resources provided by Scientific Computing."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Simone
full_name: Bombari, Simone
id: ca726dda-de17-11ea-bc14-f9da834f63aa
last_name: Bombari
citation:
ama: Bombari S. Trustworthy machine learning in high dimensions. 2026. doi:10.15479/AT-ISTA-22857
apa: Bombari, S. (2026). Trustworthy machine learning in high dimensions.
Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-22857
chicago: Bombari, Simone. “Trustworthy Machine Learning in High Dimensions.” Institute
of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-22857.
ieee: S. Bombari, “Trustworthy machine learning in high dimensions,” Institute of
Science and Technology Austria, 2026.
ista: Bombari S. 2026. Trustworthy machine learning in high dimensions. Institute
of Science and Technology Austria.
mla: Bombari, Simone. Trustworthy Machine Learning in High Dimensions. Institute
of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-22857.
short: S. Bombari, Trustworthy Machine Learning in High Dimensions, Institute of
Science and Technology Austria, 2026.
corr_author: '1'
das_tickbox: '0'
date_created: 2026-09-08T13:40:08Z
date_published: 2026-09-08T00:00:00Z
date_updated: 2026-10-16T10:42:36Z
day: '08'
ddc:
- '519'
degree_awarded: PhD
department:
- _id: GradSch
- _id: MaMo
doi: 10.15479/AT-ISTA-22857
doi_confirm: '1'
file:
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checksum: 8eab99d6dc6e4476826bdfc7c00fdebb
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date_created: 2026-09-08T13:28:38Z
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checksum: 007033bafe4622ff4c2e758301354df1
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creator: sbombari
date_created: 2026-09-10T10:03:48Z
date_updated: 2026-09-10T10:03:48Z
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success: 1
file_date_updated: 2026-09-10T10:03:48Z
fulldoi: https://doi.org/10.15479/AT-ISTA-22857
has_accepted_license: '1'
keyword:
- machine learning
- high-dimensional statistics
- deep learning theory
- privacy
- memorization
- robustness
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '446'
project:
- _id: 92099302-16d5-11f0-9cad-f9a785f54fbd
name: 'Trustworthy Deep Learning Theory: Private Over-Parameterized Models and Robust
LLMs'
- _id: 911e6d1f-16d5-11f0-9cad-c5c68c6a1cdf
grant_number: '101161364'
name: 'Inference in High Dimensions: Light-speed Algorithms and Information Limits'
- _id: 74caaef7-b034-11f1-8f2d-e0e993bb422e
grant_number: COE12
name: Bilateral Artificial Intelligence (Mondelli)
publication_identifier:
isbn:
- 978-3-99078-091-6
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
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- id: '21324'
relation: part_of_dissertation
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relation: part_of_dissertation
status: public
- id: '19627'
relation: part_of_dissertation
status: public
- id: '12859'
relation: part_of_dissertation
status: public
- id: '18973'
relation: part_of_dissertation
status: public
- id: '18972'
relation: part_of_dissertation
status: public
researchdata_availability: no
status: public
supervisor:
- first_name: Marco
full_name: Mondelli, Marco
id: 27EB676C-8706-11E9-9510-7717E6697425
last_name: Mondelli
orcid: 0000-0002-3242-7020
supplementarymaterial: no
title: Trustworthy machine learning in high dimensions
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '23043'
abstract:
- lang: eng
text: Mendelian randomization, the standard instrument variable causal-inference
approach for genomics, can be severely biased by inadequate selection of appropriate
instrument variables and horizontal pleiotropy. We introduce Causal Inference
GWAS, a graphical approach that selects genetic instruments from summary statistics
controlling for linkage and pleiotropy, accommodates rare variants and binary
outcomes, distinguishes direct from indirect risk factors in high dimensions,
and flags latent confounding. Applied to 9 risk factors, 4 metabolic disease outcomes,
and 8.4M variants across 458,747 UK Biobank individuals, our method runs in 20
minutes, identifying only 696 genome-wide valid instruments. We replicate nearly
all previously reported risk factor-outcome paths, but find that most are indistinguishable
from unmeasured confounding. This suggests robust biobank causal inference will
require longitudinal and family data to resolve temporal precedence from reverse
causation. Our approach offers a principled first step toward screening genuine
causal signal from phenotypic correlation in biobank data.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: "We thank Zoltan Kutalik andmembers of the Robinson group at ISTA
for\r\ntheir comments, which improved this manuscript. We would like to\r\nacknowledge
the participants and investigators of the UK Biobank study.\r\nHigh-performance
computing was supported by the Scientific Service\r\nUnits (SSU) of IST Austria
through resources provided by Scientific\r\nComputing (SciComp). This work was funded
by a research collaboration agreement between\r\nBoehringer Ingelheim and the research
group of MRR at the Institute of\r\nScience and Technology Austria. Additional funding
was also provided\r\nby an SNSF Eccellenza Grant to MRR (PCEGP3-181181), and by
core\r\nfunding from the Institute of Science and Technology Austria. MB was\r\nfunded
by the National Science Center Poland grant SONATINA UMO-\r\n2021/40/C/NZ2/00218."
article_number: '10153 '
article_processing_charge: Yes
article_type: original
author:
- first_name: Nick N
full_name: Machnik, Nick N
id: 3591A0AA-F248-11E8-B48F-1D18A9856A87
last_name: Machnik
orcid: 0000-0001-6617-9742
- first_name: Seyed Mahdi
full_name: Mahmoudi, Seyed Mahdi
id: b9f6d5ef-7774-11eb-a47f-df2c75c02ee7
last_name: Mahmoudi
- first_name: Malgorzata
full_name: Borczyk, Malgorzata
last_name: Borczyk
- first_name: Ilse
full_name: Krätschmer, Ilse
id: 30d4014e-7753-11eb-b44b-db6d61112e73
last_name: Krätschmer
orcid: 0000-0002-5636-9259
- first_name: Markus J.
full_name: Bauer, Markus J.
last_name: Bauer
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
citation:
ama: Machnik NN, Mahmoudi SM, Borczyk M, Krätschmer I, Bauer MJ, Robinson MR. Causal
inference for multiple risk factors and diseases from genomics data. Nature
Communications. 2026;17. doi:10.1038/s41467-026-76877-7
apa: Machnik, N. N., Mahmoudi, S. M., Borczyk, M., Krätschmer, I., Bauer, M. J.,
& Robinson, M. R. (2026). Causal inference for multiple risk factors and diseases
from genomics data. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-026-76877-7
chicago: Machnik, Nick N, Seyed Mahdi Mahmoudi, Malgorzata Borczyk, Ilse Krätschmer,
Markus J. Bauer, and Matthew Richard Robinson. “Causal Inference for Multiple
Risk Factors and Diseases from Genomics Data.” Nature Communications. Springer
Nature, 2026. https://doi.org/10.1038/s41467-026-76877-7.
ieee: N. N. Machnik, S. M. Mahmoudi, M. Borczyk, I. Krätschmer, M. J. Bauer, and
M. R. Robinson, “Causal inference for multiple risk factors and diseases from
genomics data,” Nature Communications, vol. 17. Springer Nature, 2026.
ista: Machnik NN, Mahmoudi SM, Borczyk M, Krätschmer I, Bauer MJ, Robinson MR. 2026.
Causal inference for multiple risk factors and diseases from genomics data. Nature
Communications. 17, 10153.
mla: Machnik, Nick N., et al. “Causal Inference for Multiple Risk Factors and Diseases
from Genomics Data.” Nature Communications, vol. 17, 10153, Springer Nature,
2026, doi:10.1038/s41467-026-76877-7.
short: N.N. Machnik, S.M. Mahmoudi, M. Borczyk, I. Krätschmer, M.J. Bauer, M.R.
Robinson, Nature Communications 17 (2026).
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: "This project uses the UK Biobank data under project number
35520.\r\nUK Biobank genotypic and phenotypic data is available through a\r\nformal
request at (http://www.ukbiobank.ac.uk). All of the data generated\r\nin this study
are provided in the Source Data file. Source data\r\nare provided with this paper.
The CI-GWAS code is fully open source and available at https://github.\r\ncom/medical-genomics-group/ci-gwasand
has been archived on\r\nZenodo52. The scripts used to execute the model are available
at\r\nhttps://github.com/medical-genomics-group/ci-gwas. R version 4.2.1 is\r\navailable
at https://www.r-project.org/. Plink version 1.9 is available at\r\nhttps://www.cog-genomics.org/plink/1.9/."
date_created: 2026-10-04T22:01:53Z
date_published: 2026-08-25T00:00:00Z
date_updated: 2026-10-16T11:01:16Z
day: '25'
ddc:
- '570'
department:
- _id: MaRo
doi: 10.1038/s41467-026-76877-7
file:
- access_level: open_access
checksum: 05517674168a275c70f18e964ce33d8b
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creator: dernst
date_created: 2026-10-07T09:50:18Z
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has_accepted_license: '1'
intvolume: ' 17'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '08'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
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relation: earlier_version
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researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: no
title: Causal inference for multiple risk factors and diseases from genomics data
tmp:
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legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
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short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '23152'
abstract:
- lang: eng
text: "We present a panchromatic optical-millimeter characterization of GNz7q, a
recently identified X-ray-weak,\r\nrapidly growing red quasar embedded within
a dusty starburst galaxy at z = 7.1899, using the full suite of JWST/\r\nNIRCam,
NIRSpec, Mid-Infrared Instrument (MIRI), and archival NOEMA observations. Our
deep NIRSpec/\r\nG395M spectroscopy reveals unambiguous broad Balmer emission
(FWHM = 2221 ± 20 km s\r\n−1\r\n), confirming a\r\nsuper-Eddington accreting black
hole (BH) (λEdd = 2.7 ± 0.4) with a mass of\r\nlog(MBH/M ) = 7.55 ± 0.34,\r\nusing
accretion-rate-corrected BH mass estimators. After subtracting the point source,
we robustly detect stellar\r\nemission from the host galaxy across multiple NIRCam
and MIRI filters. Our joint morphological-spectral\r\nanalysis yields a stellar
mass of = ± * log(M /M ) 10.5 0.4\r\nand an intense star formation rate of\r\nSFR
= 330 ± 97 M⊙ yr−1\r\n, confirming the host as a massive, dusty starburst galaxy.
We find that GNz7q lies\r\non the local MBH–M* relation (MBH/M* ≃ 0.001) and is
well positioned to evolve into the locus of massive Sloan\r\nDigital Sky Survey
(SDSS) quasars with\r\nlog(MBH/M ) 9\r\nand M* ≈ 1011 M⊙ at z ∼ 6, owing to its
remarkably\r\nrapid growth in both the BH and its host galaxy. This stands in
stark contrast to many recently reported JWST\r\nactive galactic nucleus populations
at similar redshifts, including the little red dots, whose weak or undetected
star\r\nformation makes it difficult for them to grow into the massive galaxies
hosting SDSS-like quasars. These results\r\nsuggest that GNz7q marks a rare, pivotal
phase of early BH–galaxy coevolution, plausibly providing a crucial\r\ndirect
pathway to the supermassive BH systems within the first billion years of the Universe."
acknowledgement: "We are grateful to Jinyi Yang and Feige Wang for their insightful
discussions about the broad-line fitting. We are grateful to Zhiwei Pan and Yuming
Fu for their discussions about the BH mass estimator.\r\n\r\nK.I. acknowledges support
from the National Natural Science Foundation of China (12573015, W2532003), the
Beijing Natural Science Foundation (IS25003), and the China Manned Space Program
(CMS-CSST-2025-A09). LCH was supported by the National Science Foundation of China
(12233001) and the China Manned Space Program (CMS-CSST-2025-A09). P.G.P.-G. acknowledges
support from grant PID2022-139567NB-I00 funded by the Spanish Ministerio de Ciencia,
Innovación y Universidades MCIU/AEI/10.13039/501100011033, FEDER Una manera de hacer
Europa. J.A.-M. acknowledges support by grants PID2024-158856NA-I00 & PIB2021-127718NB-I00
from the Spanish Ministry of Science and Innovation/State Agency of Research MCIN/AEI/10.13039/501100011033
and by “ERDF A way of making Europe.”\r\n\r\nThis work is based on observations
made with the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from
the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute,
which is operated by the Association of Universities for Research in Astronomy,
Inc., under NASA contract NAS 5-03127 for JWST. The specific observations analyzed
can be accessed via DOI: 10.17909/q19z-a348for the GNz7q observations and DOI: 10.17909/0akt-xx69for
the MIRI images from the MEOW survey. These observations are associated with programs
# 4762 and # 5407."
article_number: '86'
article_processing_charge: Yes
article_type: original
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author:
- first_name: Qinyue
full_name: Fei, Qinyue
last_name: Fei
- first_name: Seiji
full_name: Fujimoto, Seiji
last_name: Fujimoto
- first_name: Gabriel
full_name: Brammer, Gabriel
last_name: Brammer
- first_name: Ruancun
full_name: Li, Ruancun
last_name: Li
- first_name: Luis C.
full_name: Ho, Luis C.
last_name: Ho
- first_name: Volker
full_name: Bromm, Volker
last_name: Bromm
- first_name: Javier
full_name: Álvarez-Márquez, Javier
last_name: Álvarez-Márquez
- first_name: Yoshihisa
full_name: Asada, Yoshihisa
last_name: Asada
- first_name: Guillermo
full_name: Barro, Guillermo
last_name: Barro
- first_name: Luis
full_name: Colina, Luis
last_name: Colina
- first_name: Pratika
full_name: Dayal, Pratika
last_name: Dayal
- first_name: Steven L.
full_name: Finkelstein, Steven L.
last_name: Finkelstein
- first_name: Johan P.U.
full_name: Fynbo, Johan P.U.
last_name: Fynbo
- first_name: Michele
full_name: Ginolfi, Michele
last_name: Ginolfi
- first_name: Kohei
full_name: Inayoshi, Kohei
last_name: Inayoshi
- first_name: Vasily
full_name: Kokorev, Vasily
last_name: Kokorev
- first_name: Gene C.K.
full_name: Leung, Gene C.K.
last_name: Leung
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Romain A.
full_name: Meyer, Romain A.
last_name: Meyer
- first_name: Rohan P.
full_name: Naidu, Rohan P.
last_name: Naidu
- first_name: Masafusa
full_name: Onoue, Masafusa
last_name: Onoue
- first_name: Pablo G.
full_name: Pérez-González, Pablo G.
last_name: Pérez-González
- first_name: Charles L.
full_name: Steinhardt, Charles L.
last_name: Steinhardt
- first_name: Francesco
full_name: Valentino, Francesco
last_name: Valentino
- first_name: Fabian
full_name: Walter, Fabian
last_name: Walter
- first_name: Mengyuan
full_name: Xiao, Mengyuan
last_name: Xiao
- first_name: Haowen
full_name: Zhang, Haowen
last_name: Zhang
citation:
ama: 'Fei Q, Fujimoto S, Brammer G, et al. Direct pathway to the early supermassive
Black Holes: A red super-Eddington quasar in a massive starburst host at z = 7.2.
The Astrophysical Journal. 2026;1010(1). doi:10.3847/1538-4357/aea07b'
apa: 'Fei, Q., Fujimoto, S., Brammer, G., Li, R., Ho, L. C., Bromm, V., … Zhang,
H. (2026). Direct pathway to the early supermassive Black Holes: A red super-Eddington
quasar in a massive starburst host at z = 7.2. The Astrophysical Journal.
IOP Publishing. https://doi.org/10.3847/1538-4357/aea07b'
chicago: 'Fei, Qinyue, Seiji Fujimoto, Gabriel Brammer, Ruancun Li, Luis C. Ho,
Volker Bromm, Javier Álvarez-Márquez, et al. “Direct Pathway to the Early Supermassive
Black Holes: A Red Super-Eddington Quasar in a Massive Starburst Host at z = 7.2.”
The Astrophysical Journal. IOP Publishing, 2026. https://doi.org/10.3847/1538-4357/aea07b.'
ieee: 'Q. Fei et al., “Direct pathway to the early supermassive Black Holes:
A red super-Eddington quasar in a massive starburst host at z = 7.2,” The Astrophysical
Journal, vol. 1010, no. 1. IOP Publishing, 2026.'
ista: 'Fei Q, Fujimoto S, Brammer G, Li R, Ho LC, Bromm V, Álvarez-Márquez J, Asada
Y, Barro G, Colina L, Dayal P, Finkelstein SL, Fynbo JPU, Ginolfi M, Inayoshi
K, Kokorev V, Leung GCK, Matthee JJ, Meyer RA, Naidu RP, Onoue M, Pérez-González
PG, Steinhardt CL, Valentino F, Walter F, Xiao M, Zhang H. 2026. Direct pathway
to the early supermassive Black Holes: A red super-Eddington quasar in a massive
starburst host at z = 7.2. The Astrophysical Journal. 1010(1), 86.'
mla: 'Fei, Qinyue, et al. “Direct Pathway to the Early Supermassive Black Holes:
A Red Super-Eddington Quasar in a Massive Starburst Host at z = 7.2.” The Astrophysical
Journal, vol. 1010, no. 1, 86, IOP Publishing, 2026, doi:10.3847/1538-4357/aea07b.'
short: Q. Fei, S. Fujimoto, G. Brammer, R. Li, L.C. Ho, V. Bromm, J. Álvarez-Márquez,
Y. Asada, G. Barro, L. Colina, P. Dayal, S.L. Finkelstein, J.P.U. Fynbo, M. Ginolfi,
K. Inayoshi, V. Kokorev, G.C.K. Leung, J.J. Matthee, R.A. Meyer, R.P. Naidu, M.
Onoue, P.G. Pérez-González, C.L. Steinhardt, F. Valentino, F. Walter, M. Xiao,
H. Zhang, The Astrophysical Journal 1010 (2026).
das_tickbox: '1'
dataavailabilitystatement: "The reduced 1D NIRSpec/G395M spectra, the MIRI LRS 1D
extraction, and the MIRI MRS 1D extraction used in this work are publicly available
on Zenodo at DOI: 10.5281/zenodo.21539999.\r\nFacilities: JWST - James Webb Space
Telescope, IRAM:NOEMA. -\r\nSoftware: GalfitS (R. Li et al. 2026), LMFIT (M. Newville
et al. 2014), grizli (G. Brammer & J. Matharu 2021), msaexp (G. Brammer 2023)"
date_created: 2026-10-18T22:01:51Z
date_published: 2026-10-10T00:00:00Z
date_updated: 2026-10-19T06:48:25Z
day: '10'
ddc:
- '520'
department:
- _id: JoMa
doi: 10.3847/1538-4357/aea07b
external_id:
arxiv:
- '2602.12325'
file:
- access_level: open_access
checksum: b319631e496b3f50fd32202bb19a5b99
content_type: application/pdf
creator: dernst
date_created: 2026-10-19T06:36:24Z
date_updated: 2026-10-19T06:36:24Z
file_id: '23162'
file_name: 2026_AstrophysicalJour_FeiQinyue.pdf
file_size: 3985652
relation: main_file
success: 1
file_date_updated: 2026-10-19T06:36:24Z
fulldoi: https://doi.org/10.3847/1538-4357/aea07b
has_accepted_license: '1'
intvolume: ' 1010'
issue: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '10'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: 'Direct pathway to the early supermassive Black Holes: A red super-Eddington
quasar in a massive starburst host at z = 7.2'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1010
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '23148'
abstract:
- lang: eng
text: Presenilin-1 (PS1) is an endoplasmic reticulum protein, most known for its
role in pathogenesis of familial Alzheimer’s Disease (AD). PS1 has been attributed
roles in intracellular calcium homeostasis in the brain, as well as in the pancreatic
beta cells, where it has been shown to be fundamental for the initial phase of
glucose-induced insulin secretion. To gain mechanistic insight into beta cell
autonomous function of PS1, we have examined various beta cell models and found
that PS1 controls glycolytic flux of pancreatic beta cells by regulating sub-mitochondrial
Ca2+ homeostasis. Transient knock down of PS1 yielded a glycolytic bottleneck
at the step catalyzed by glyceraldehyde-3-phosphate dehydrogenase, resulting in
defective glucose responsiveness. Moreover, we show that PS1 is needed for the
preservation of beta cell identity, likely due to its role in glycolysis. Finally,
we show that mouse islets from an in vivo model of AD mimic the defective glucose
responsiveness seen in beta cells with transient PS1 knock down, while the identity
loss and whole-body glucose homeostasis are not severely impacted, suggesting
an adaptive response. Thus, the current work highlights beta cell autonomous role
of PS1 and adds a layer of complexity in its impact on whole body metabolism.
acknowledgement: We appreciate the technical assistance from Anna Schreilechner. We
are grateful for support by all members of the animal facility team at IMB, University
of Graz, as well as K. Zierler for assistance with animal licenses. F.M, T.E.,
T.M., T.P., and W.F.G. are grateful to the Austrian Science Fund (FWF) for the excellence
cluster 10.55776/COE14 (MetAGE), which was additionally supported by Land Styria,
Stadt Graz, University of Graz and Medical University of Graz. This research was
further supported by the FWF via the DKplus program 10.55776/W1226 (DK-MCD) to F.M.,
T.M., R.B.G., and W.F.G., 10.55776/P28529, 10.55776/I3716 (to R.M.), 10.55776/P28854,
10.55776/I3792, 10.55776/DOC130 (to T.M.), and 10.55776/I4319 (to. M.S.R.); the
Austrian Research Promotion Agency (FFG) grants 864690 and 870454; the Integrative
Metabolism Research Center Graz; the Austrian Infrastructure Program 2016/2017 (to
T.M.), and 10.55776/COE7, 10.55776/COE17, 10.55776/FG12 and 10.55776/F73 (to R.B.G.);
the Styrian Government; the City of Graz; and BioTechMed-Graz (flagship project)
(to T.M.); the MEFO Graz (to W.F.G.). F.E.O., J.G. and Z.K. were doctoral fellows
in the doctoral program Metabolic and Cardiovascular Disease (MCD) (FWF, 10.55776/W
1226) at the Medical University of Graz. S.v.A. and A.S. are thesis students in
the excellence cluster 10.55776/COE14 (MetAGE, W.F.G.). M.H. was a fellow of the
Molecular Medicine (MolMed) doctoral program at the Medical University of Graz supported
by MEFO Graz. The SIM equipment is part of the Nikon Center of Excellence, Graz,
and is supported by the Austrian infrastructure program 2013/ 2014, Nikon Austria
Inc., and BioTechMed (to W.F.G.). Our thanks go to Shimadzu Austria for supporting
this research through instrument access given in the Metabolomics and Bioprocess
Analytics laboratory (TU Wien) (R.B.G.). For open access purposes, the authors have
applied a CC BY public copyright license to any author-accepted manuscript version
arising from this submission.” We thank the Medical University of Graz for financial
support.
article_number: '1315'
article_processing_charge: Yes
article_type: original
author:
- first_name: Zhanat
full_name: Koshenov, Zhanat
last_name: Koshenov
- first_name: Sandra
full_name: Postic, Sandra
last_name: Postic
- first_name: Gabriela
full_name: Schoiswohl, Gabriela
last_name: Schoiswohl
- first_name: Savina
full_name: Van Amsterdam, Savina
last_name: Van Amsterdam
- first_name: Victoria
full_name: Hois-Zelinka, Victoria
last_name: Hois-Zelinka
- first_name: Furkan E.
full_name: Oflaz, Furkan E.
last_name: Oflaz
- first_name: Rene
full_name: Rost, Rene
last_name: Rost
- first_name: Oleksandra
full_name: Tiapko, Oleksandra
last_name: Tiapko
- first_name: Benjamin
full_name: Gottschalk, Benjamin
last_name: Gottschalk
- first_name: Martin
full_name: Hirtl, Martin
last_name: Hirtl
- first_name: Olaf G.
full_name: Bachkoenig, Olaf G.
last_name: Bachkoenig
- first_name: Aigerim
full_name: Koshenova, Aigerim
last_name: Koshenova
- first_name: Yusuf C.
full_name: Erdogan, Yusuf C.
last_name: Erdogan
- first_name: Adlet
full_name: Sagintayev, Adlet
last_name: Sagintayev
- first_name: Anita
full_name: Krnjic, Anita
last_name: Krnjic
- first_name: Johannes U.
full_name: Pfabe, Johannes U.
last_name: Pfabe
- first_name: Srdjan
full_name: Sarikas, Srdjan
id: 35F0286E-F248-11E8-B48F-1D18A9856A87
last_name: Sarikas
- first_name: Bernhard
full_name: Hochreiter, Bernhard
id: e6cab3de-17f6-11ed-9210-c1e42e045e9d
last_name: Hochreiter
- first_name: Juergen
full_name: Gindlhuber, Juergen
last_name: Gindlhuber
- first_name: Matthias
full_name: Schittmayer, Matthias
last_name: Schittmayer
- first_name: Jelena
full_name: Tadic, Jelena
last_name: Tadic
- first_name: Barbara
full_name: Ehall, Barbara
last_name: Ehall
- first_name: Frank
full_name: Madeo, Frank
last_name: Madeo
- first_name: Tobias
full_name: Madl, Tobias
last_name: Madl
- first_name: Roland
full_name: Malli, Roland
last_name: Malli
- first_name: Ruth
full_name: Birner-Gruenberger, Ruth
last_name: Birner-Gruenberger
- first_name: Thomas
full_name: Pieber, Thomas
last_name: Pieber
- first_name: Tobias
full_name: Eisenberg, Tobias
last_name: Eisenberg
- first_name: Marjan
full_name: Slak Rupnik, Marjan
last_name: Slak Rupnik
- first_name: Wolfgang F.
full_name: Graier, Wolfgang F.
last_name: Graier
citation:
ama: Koshenov Z, Postic S, Schoiswohl G, et al. Presenilin-1 controls glycolysis
and identity of pancreatic beta cells. Communications Biology. 2026;9.
doi:10.1038/s42003-026-10581-6
apa: Koshenov, Z., Postic, S., Schoiswohl, G., Van Amsterdam, S., Hois-Zelinka,
V., Oflaz, F. E., … Graier, W. F. (2026). Presenilin-1 controls glycolysis and
identity of pancreatic beta cells. Communications Biology. Springer Nature.
https://doi.org/10.1038/s42003-026-10581-6
chicago: Koshenov, Zhanat, Sandra Postic, Gabriela Schoiswohl, Savina Van Amsterdam,
Victoria Hois-Zelinka, Furkan E. Oflaz, Rene Rost, et al. “Presenilin-1 Controls
Glycolysis and Identity of Pancreatic Beta Cells.” Communications Biology.
Springer Nature, 2026. https://doi.org/10.1038/s42003-026-10581-6.
ieee: Z. Koshenov et al., “Presenilin-1 controls glycolysis and identity
of pancreatic beta cells,” Communications Biology, vol. 9. Springer Nature,
2026.
ista: Koshenov Z, Postic S, Schoiswohl G, Van Amsterdam S, Hois-Zelinka V, Oflaz
FE, Rost R, Tiapko O, Gottschalk B, Hirtl M, Bachkoenig OG, Koshenova A, Erdogan
YC, Sagintayev A, Krnjic A, Pfabe JU, Sarikas S, Hochreiter B, Gindlhuber J, Schittmayer
M, Tadic J, Ehall B, Madeo F, Madl T, Malli R, Birner-Gruenberger R, Pieber T,
Eisenberg T, Slak Rupnik M, Graier WF. 2026. Presenilin-1 controls glycolysis
and identity of pancreatic beta cells. Communications Biology. 9, 1315.
mla: Koshenov, Zhanat, et al. “Presenilin-1 Controls Glycolysis and Identity of
Pancreatic Beta Cells.” Communications Biology, vol. 9, 1315, Springer
Nature, 2026, doi:10.1038/s42003-026-10581-6.
short: Z. Koshenov, S. Postic, G. Schoiswohl, S. Van Amsterdam, V. Hois-Zelinka,
F.E. Oflaz, R. Rost, O. Tiapko, B. Gottschalk, M. Hirtl, O.G. Bachkoenig, A. Koshenova,
Y.C. Erdogan, A. Sagintayev, A. Krnjic, J.U. Pfabe, S. Sarikas, B. Hochreiter,
J. Gindlhuber, M. Schittmayer, J. Tadic, B. Ehall, F. Madeo, T. Madl, R. Malli,
R. Birner-Gruenberger, T. Pieber, T. Eisenberg, M. Slak Rupnik, W.F. Graier, Communications
Biology 9 (2026).
das_tickbox: '1'
dataavailabilitystatement: The data supporting the findings of this research can be
obtained from the authors upon a reasonable request; please refer to the author’s
contributions for details regarding specific datasets. Numerical source data underlying
graphs in this article can be found in Supplementary data file. Supplementary Figs.
and figure legends are included in the Supplementary file. The code used in this
study is available from the authors on reasonable request.
date_created: 2026-10-18T22:01:50Z
date_published: 2026-10-08T00:00:00Z
date_updated: 2026-10-19T06:23:26Z
day: '08'
ddc:
- '570'
department:
- _id: FISS
doi: 10.1038/s42003-026-10581-6
external_id:
pmid:
- '42387039'
file:
- access_level: open_access
checksum: b90e60a625fcac8ef5d9ff968792d675
content_type: application/pdf
creator: dernst
date_created: 2026-10-19T06:19:39Z
date_updated: 2026-10-19T06:19:39Z
file_id: '23161'
file_name: 2026_CommunicationsBiology_Koshenov.pdf
file_size: 1819866
relation: main_file
success: 1
file_date_updated: 2026-10-19T06:19:39Z
fulldoi: https://doi.org/10.1038/s42003-026-10581-6
has_accepted_license: '1'
intvolume: ' 9'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
publication: Communications Biology
publication_identifier:
eissn:
- 2399-3642
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: upon request
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Presenilin-1 controls glycolysis and identity of pancreatic beta cells
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '23150'
abstract:
- lang: eng
text: "High-redshift supermassive black holes (SMBHs) have challenged our understanding
of black hole formation and growth. The ‘heavy-seed’ pathway eases the problem
with the progenitors of these SMBHs having birth masses up to∼105 M\x03. Here,
we investigate the possibility that a local dwarf galaxy, Leo I, harbours a heavy-seed
descendant. Using Monte Carlo merger trees to generate the merger histories of
1000 dark matter haloes similar to the Milky Way (MW), we search for Leo- like
satellite haloes and investigate the probability that the progenitors of these
satellites formed a heavy seed. We derive the likelihood of such ‘heavy-seed survivors’
(HSSs) across various formation and survival criteria as well as Leo-similarity
criteria. We find that the virial temperature for the onset of atomic cooling
and rapid gas infall that yields heavy seeds, Tact , has the largest impact on
HSS frequency. We find HSSs in a fraction 0.7 per cent, 18.1 per cent, and 96.5
per cent of MW-like haloes when Tact is set to 9000, 7000, and 5000 K, respectively.
For the canonical atomic-cooling threshold ( Tact \x02 8000 K), the HSS fraction
is\x03 1per cent , indicating that Leo I hosting a heavy-seed descendant is unlikely
under well-motivated physical assumptions. Higher HSS fractions occur only under
optimistic and currently unsubstantiated assumptions on Tact . Nevertheless, these
results motivate future work that clarifies the possibility of heavy-seed BH formation
in pristine haloes with nominal virial temperatures below 8000 K. This may motivate
Leo I as a target for disentangling heavy seeds from other SMBH formation mechanisms."
acknowledgement: We thank the anonymous reviewer for feedback that helped clarify
this manuscript. ZH acknowledges support from NSF grant AST-2006176. FP acknowledges
support from the Black Hole Initiative at Harvard University, which is funded by
grants from the John Templeton Foundation and the Gordon and Betty Moore Foundation.
Merger tree generation and analysis were performed with NSF’s ACCESS allocations
AST-120046 and AST-140041 on the Stampede3 resource. The freely available plotting
library matplotlib (J. D. Hunter 2007) was used to construct the plots in this paper.
article_number: stag1839
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Matthew T.
full_name: Scoggins, Matthew T.
last_name: Scoggins
- first_name: Zoltán
full_name: Haiman, Zoltán
id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
last_name: Haiman
orcid: 0000-0003-3633-5403
- first_name: Fabio
full_name: Pacucci, Fabio
last_name: Pacucci
citation:
ama: 'Scoggins MT, Haiman Z, Pacucci F. Heavy black hole seed survivors in dwarf
galaxies: A case study of Leo I. Monthly Notices of the Royal Astronomical
Society. 2026;552(3). doi:10.1093/mnras/stag1839'
apa: 'Scoggins, M. T., Haiman, Z., & Pacucci, F. (2026). Heavy black hole seed
survivors in dwarf galaxies: A case study of Leo I. Monthly Notices of the
Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/stag1839'
chicago: 'Scoggins, Matthew T., Zoltán Haiman, and Fabio Pacucci. “Heavy Black Hole
Seed Survivors in Dwarf Galaxies: A Case Study of Leo I.” Monthly Notices of
the Royal Astronomical Society. Oxford University Press, 2026. https://doi.org/10.1093/mnras/stag1839.'
ieee: 'M. T. Scoggins, Z. Haiman, and F. Pacucci, “Heavy black hole seed survivors
in dwarf galaxies: A case study of Leo I,” Monthly Notices of the Royal Astronomical
Society, vol. 552, no. 3. Oxford University Press, 2026.'
ista: 'Scoggins MT, Haiman Z, Pacucci F. 2026. Heavy black hole seed survivors in
dwarf galaxies: A case study of Leo I. Monthly Notices of the Royal Astronomical
Society. 552(3), stag1839.'
mla: 'Scoggins, Matthew T., et al. “Heavy Black Hole Seed Survivors in Dwarf Galaxies:
A Case Study of Leo I.” Monthly Notices of the Royal Astronomical Society,
vol. 552, no. 3, stag1839, Oxford University Press, 2026, doi:10.1093/mnras/stag1839.'
short: M.T. Scoggins, Z. Haiman, F. Pacucci, Monthly Notices of the Royal Astronomical
Society 552 (2026).
das_tickbox: '1'
dataavailabilitystatement: The code used to analyse the merger trees and generate
figures for this manuscript is available at this GitHub repository. All other data
will be shared upon reasonable request to the corresponding author.
date_created: 2026-10-18T22:01:51Z
date_published: 2026-11-01T00:00:00Z
date_updated: 2026-10-19T07:05:55Z
day: '01'
ddc:
- '520'
department:
- _id: ZoHa
doi: 10.1093/mnras/stag1839
external_id:
arxiv:
- '2511.04736'
file:
- access_level: open_access
checksum: 99a35f1305b7f1ed3813bcd51ba16724
content_type: application/pdf
creator: dernst
date_created: 2026-10-19T07:05:43Z
date_updated: 2026-10-19T07:05:43Z
file_id: '23164'
file_name: 2026_MonthNoticesRAS_Scoggins.pdf
file_size: 1450204
relation: main_file
success: 1
file_date_updated: 2026-10-19T07:05:43Z
fulldoi: https://doi.org/10.1093/mnras/stag1839
has_accepted_license: '1'
intvolume: ' 552'
issue: '3'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: no
title: 'Heavy black hole seed survivors in dwarf galaxies: A case study of Leo I'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 552
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '23151'
abstract:
- lang: eng
text: "We present deep, narrowband Gemini North/GMOS images of the Pa 30 nebula
that reveal rich small-scale\r\nstructure in the ejecta filaments. In [S II],
the number of detected filaments increases by about an order of\r\nmagnitude compared
to previous studies. The imaging further reveals that the filaments are not smooth
radial\r\nstreaks, but instead are composed of cascades of knots or clumps. The
images in [O III] yield the first confirmation\r\nthat previously detected diffuse
[O III] emission in fact originates from the same [S II] filaments. We measure
a\r\nnebula center consistent with the position of the central star, indicating
that the remnant has not received a large\r\ntransverse kick. The 3σ upper limit
on the velocity of the stellar kick is ≲100 km s\r\n−1\r\n. Cross-sectional profiles
of\r\nthe filaments in [S II] and [O III] show a central peak on top of a nebula
background, the latter being likely due to\r\ndiffuse emission or unresolved filaments.
The median [S II] width of 0.7 is slightly broader than the 0.50 seeing,\r\nproviding
some evidence of partially resolved filaments and implying a characteristic knot
diameter of ∼1016 cm.\r\nThe ≈1″ widths measured in [O III] are consistent with
the poorer seeing of the oxygen images. The discovery of\r\nthis clumpy substructure
provides a new observational constraint on models for the origin and evolution
of the\r\nremarkable filamentary ejecta of Pa 30."
acknowledgement: "We thank Jim Fuller, SR Kulkarni, David Charbonneau, Paul Duffell,
Abigail Polin, Miranda Pikus, Tony Piro, Lars Bildsten, Eliot Quartert, and Rob
Fesen for helpful discussions. This work was supported by NASA through the NASA
Hubble Fellowship grant HST-HF2-51527.001-A awarded by the Space Telescope Science
Institute, which is operated by the Association of Universities for Research in
Astronomy, Inc., for NASA, under contract NAS5-26555.\r\n\r\nFacility: Gemini:Gillett
(GMOS-N) - .\r\n\r\nSoftware: astropy (Astropy Collaboration et al. 2013, 2018),
scipy (P. Virtanen et al. 2020), emcee (D. Foreman-Mackey et al. 2013), DRAGONS
(K. Labrie et al. 2023), DS9 (W. A. Joye & E. Mandel 2003)."
article_number: '28'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Tim
full_name: Cunningham, Tim
last_name: Cunningham
- first_name: Ilaria
full_name: Caiazzo, Ilaria
id: 8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d
last_name: Caiazzo
orcid: 0000-0002-4770-5388
- first_name: John C.
full_name: Raymond, John C.
last_name: Raymond
- first_name: Scott J.
full_name: Kenyon, Scott J.
last_name: Kenyon
citation:
ama: Cunningham T, Caiazzo I, Raymond JC, Kenyon SJ. Detection of knots in the type
Iax supernova remnant Pa 30. The Astrophysical Journal. 2026;1010(1). doi:10.3847/1538-4357/ae9cb2
apa: Cunningham, T., Caiazzo, I., Raymond, J. C., & Kenyon, S. J. (2026). Detection
of knots in the type Iax supernova remnant Pa 30. The Astrophysical Journal.
IOP Publishing. https://doi.org/10.3847/1538-4357/ae9cb2
chicago: Cunningham, Tim, Ilaria Caiazzo, John C. Raymond, and Scott J. Kenyon.
“Detection of Knots in the Type Iax Supernova Remnant Pa 30.” The Astrophysical
Journal. IOP Publishing, 2026. https://doi.org/10.3847/1538-4357/ae9cb2.
ieee: T. Cunningham, I. Caiazzo, J. C. Raymond, and S. J. Kenyon, “Detection of
knots in the type Iax supernova remnant Pa 30,” The Astrophysical Journal,
vol. 1010, no. 1. IOP Publishing, 2026.
ista: Cunningham T, Caiazzo I, Raymond JC, Kenyon SJ. 2026. Detection of knots in
the type Iax supernova remnant Pa 30. The Astrophysical Journal. 1010(1), 28.
mla: Cunningham, Tim, et al. “Detection of Knots in the Type Iax Supernova Remnant
Pa 30.” The Astrophysical Journal, vol. 1010, no. 1, 28, IOP Publishing,
2026, doi:10.3847/1538-4357/ae9cb2.
short: T. Cunningham, I. Caiazzo, J.C. Raymond, S.J. Kenyon, The Astrophysical Journal
1010 (2026).
corr_author: '1'
das_tickbox: '0'
date_created: 2026-10-18T22:01:51Z
date_published: 2026-10-10T00:00:00Z
date_updated: 2026-10-19T06:59:28Z
day: '10'
ddc:
- '520'
department:
- _id: IlCa
doi: 10.3847/1538-4357/ae9cb2
external_id:
arxiv:
- '2610.06424'
file:
- access_level: open_access
checksum: a31da77f9197b832da52caf1417a87de
content_type: application/pdf
creator: dernst
date_created: 2026-10-19T06:57:17Z
date_updated: 2026-10-19T06:57:17Z
file_id: '23163'
file_name: 2026_AstrophysicalJour_Cunningham.pdf
file_size: 34494943
relation: main_file
success: 1
file_date_updated: 2026-10-19T06:57:17Z
fulldoi: https://doi.org/10.3847/1538-4357/ae9cb2
has_accepted_license: '1'
intvolume: ' 1010'
issue: '1'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Detection of knots in the type Iax supernova remnant Pa 30
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1010
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '23149'
abstract:
- lang: eng
text: We prove an asymptotic formula for the number of integral points of bounded
log anticanonical height on a singular quartic del Pezzo surface over arbitrary
number fields, with respect to the largest admissible boundary divisor. The resulting
Clemens complex is more complicated than usual, and leads to particularly interesting
effective cone constants, associated with exponentially many polytopes whose volumes
appear in the expected formula. Like a jigsaw puzzle, these polytopes fit together
to one large polytope. The volume of this polytope appears in the asymptotic formula
that we obtain using the universal torsor method via o-minimal structures.
acknowledgement: Open Access funding enabled and organized by Projekt DEAL. We would
like to thank the referee for their careful reading and helpful remarks that helped
to improve this article. The first two authors were supported by the Deutsche Forschungsgemeinschaft
(DFG) – 512730679 (RTG2965). The third author was partially supported by the Caroline
Herschel Programme of Leibniz University Hannover. The fourth author was supported
by the Deutsche Forschungsgemeinschaft (DFG) – 398436923 (RTG2491).
article_number: '37'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Christian
full_name: Bernert, Christian
id: aefba9fc-4694-11f0-b73e-8bd408e8f734
last_name: Bernert
- first_name: Ulrich
full_name: Derenthal, Ulrich
last_name: Derenthal
- first_name: Judith
full_name: Ortmann, Judith
last_name: Ortmann
- first_name: Florian Alexander
full_name: Wilsch, Florian Alexander
id: 560601DA-8D36-11E9-A136-7AC1E5697425
last_name: Wilsch
orcid: 0000-0001-7302-8256
citation:
ama: 'Bernert C, Derenthal U, Ortmann J, Wilsch FA. Integral points over number
fields: a Clemens complex jigsaw puzzle. Mathematische Zeitschrift. 2026;314(3).
doi:10.1007/s00209-026-04140-2'
apa: 'Bernert, C., Derenthal, U., Ortmann, J., & Wilsch, F. A. (2026). Integral
points over number fields: a Clemens complex jigsaw puzzle. Mathematische Zeitschrift.
Springer. https://doi.org/10.1007/s00209-026-04140-2'
chicago: 'Bernert, Christian, Ulrich Derenthal, Judith Ortmann, and Florian Alexander
Wilsch. “Integral Points over Number Fields: A Clemens Complex Jigsaw Puzzle.”
Mathematische Zeitschrift. Springer, 2026. https://doi.org/10.1007/s00209-026-04140-2.'
ieee: 'C. Bernert, U. Derenthal, J. Ortmann, and F. A. Wilsch, “Integral points
over number fields: a Clemens complex jigsaw puzzle,” Mathematische Zeitschrift,
vol. 314, no. 3. Springer, 2026.'
ista: 'Bernert C, Derenthal U, Ortmann J, Wilsch FA. 2026. Integral points over
number fields: a Clemens complex jigsaw puzzle. Mathematische Zeitschrift. 314(3),
37.'
mla: 'Bernert, Christian, et al. “Integral Points over Number Fields: A Clemens
Complex Jigsaw Puzzle.” Mathematische Zeitschrift, vol. 314, no. 3, 37,
Springer, 2026, doi:10.1007/s00209-026-04140-2.'
short: C. Bernert, U. Derenthal, J. Ortmann, F.A. Wilsch, Mathematische Zeitschrift
314 (2026).
das_tickbox: '1'
dataavailabilitystatement: Our manuscript has no associated data.
date_created: 2026-10-18T22:01:50Z
date_published: 2026-11-01T00:00:00Z
date_updated: 2026-10-19T06:13:10Z
day: '01'
ddc:
- '510'
department:
- _id: TiBr
doi: 10.1007/s00209-026-04140-2
external_id:
arxiv:
- '2601.08774'
file:
- access_level: open_access
checksum: c2157633b4832a760336cd5d3f77b022
content_type: application/pdf
creator: dernst
date_created: 2026-10-19T06:11:23Z
date_updated: 2026-10-19T06:11:23Z
file_id: '23160'
file_name: 2026_MathemZeitschrift_Bernert.pdf
file_size: 593086
relation: main_file
success: 1
file_date_updated: 2026-10-19T06:11:23Z
fulldoi: https://doi.org/10.1007/s00209-026-04140-2
has_accepted_license: '1'
intvolume: ' 314'
issue: '3'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: Mathematische Zeitschrift
publication_identifier:
eissn:
- 1432-1823
issn:
- 0025-5874
publication_status: published
publisher: Springer
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: 'Integral points over number fields: a Clemens complex jigsaw puzzle'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 314
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '23156'
abstract:
- lang: eng
text: "Extracting the current-phase relationship (CPR) of a single superconducting
junction is challenging in practice and traditionally involves embedding the junction
in a larger superconducting circuit containing SQUIDs and/or resonators. Applying
ac driving to the junction has proven to be a viable and less invasive way to
extract information about the few lowest harmonics of the CPR, by locating the
integer and fractional Shapiro steps in the \U0001D43C\U0001D449-curve of the
driven junction. Here, we present an alternative driving-based method that allows
to extract the full harmonic content of a CPR in a relatively noninvasive way,
by fitting the measured critical currents of the driven junction as a function
of driving power. We test our method, both using numerical simulations and in
experiments, and we show that it works accurately."
acknowledgement: 'The authors thank Afonso Oliveira, Stefano Calcaterra, Daniel Chrastina,
and Giovanni Isella for providing the Ge/SiGe heterostructure. This work was supported
by the Research Council of Norway through its Centers of Excellence funding scheme,
Project No. 262633, “QuSpin,” the FWF Project with DOI:10.55776/PAT7682124, OeAD
“ISTA Austria: ISTernship Summer Programme, Non-EU countries” (Ref. No.: MPC-2025-00945),
the Spanish Comunidad de Madrid (CM) “Talento Program” (Project No. 2022-T1/IND-24070),
and the Spanish Ministry of Science, Innovation, and Universities through Grants
No. CEX2024-001445-S (Severo Ochoa Centres of Excellence program) and No. PID2022-140552NA-I00,
funded by MCIN/AEI/10.13039/501100011033.'
article_number: '044017'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Maxim
full_name: Tjøtta, Maxim
last_name: Tjøtta
- first_name: Devashish C
full_name: Shah, Devashish C
id: de191434-4e7e-11ef-bf4b-9a056fc19fc3
last_name: Shah
orcid: 0009-0007-5829-7707
- first_name: Kanishk
full_name: Modi, Kanishk
id: f05345fd-900f-11f1-bfd8-8c0b6eadcc7f
last_name: Modi
- first_name: Marco
full_name: Valentini, Marco
id: C0BB2FAC-D767-11E9-B658-BC13E6697425
last_name: Valentini
- first_name: Rubén
full_name: Seoane Souto, Rubén
last_name: Seoane Souto
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
- first_name: Jeroen
full_name: Danon, Jeroen
last_name: Danon
citation:
ama: Tjøtta M, Shah DC, Modi K, et al. Fast-driving spectroscopy of current-phase
relationships of individual Josephson elements. Physical Review Applied.
2026;26(4). doi:10.1103/d3gl-qntm
apa: Tjøtta, M., Shah, D. C., Modi, K., Valentini, M., Seoane Souto, R., Katsaros,
G., & Danon, J. (2026). Fast-driving spectroscopy of current-phase relationships
of individual Josephson elements. Physical Review Applied. American Physical
Society. https://doi.org/10.1103/d3gl-qntm
chicago: Tjøtta, Maxim, Devashish C Shah, Kanishk Modi, Marco Valentini, Rubén Seoane
Souto, Georgios Katsaros, and Jeroen Danon. “Fast-Driving Spectroscopy of Current-Phase
Relationships of Individual Josephson Elements.” Physical Review Applied.
American Physical Society, 2026. https://doi.org/10.1103/d3gl-qntm.
ieee: M. Tjøtta et al., “Fast-driving spectroscopy of current-phase relationships
of individual Josephson elements,” Physical Review Applied, vol. 26, no.
4. American Physical Society, 2026.
ista: Tjøtta M, Shah DC, Modi K, Valentini M, Seoane Souto R, Katsaros G, Danon
J. 2026. Fast-driving spectroscopy of current-phase relationships of individual
Josephson elements. Physical Review Applied. 26(4), 044017.
mla: Tjøtta, Maxim, et al. “Fast-Driving Spectroscopy of Current-Phase Relationships
of Individual Josephson Elements.” Physical Review Applied, vol. 26, no.
4, 044017, American Physical Society, 2026, doi:10.1103/d3gl-qntm.
short: M. Tjøtta, D.C. Shah, K. Modi, M. Valentini, R. Seoane Souto, G. Katsaros,
J. Danon, Physical Review Applied 26 (2026).
das_tickbox: '1'
dataavailabilitystatement: The data that support the findings of this article are
openly available at [10.5281/zenodo.22646275].
date_created: 2026-10-18T22:01:52Z
date_published: 2026-10-01T00:00:00Z
date_updated: 2026-10-19T07:25:01Z
day: '01'
department:
- _id: GeKa
- _id: GradSch
doi: 10.1103/d3gl-qntm
external_id:
arxiv:
- '2511.14313'
fulldoi: https://doi.org/10.1103/d3gl-qntm
intvolume: ' 26'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2511.14313
month: '10'
oa: 1
oa_version: Preprint
project:
- _id: 5b9e579c-ab3d-11f0-914f-88754c5b5a3f
grant_number: PAT 7682124
name: Superconducting spin qubits in planar Ge
publication: Physical Review Applied
publication_identifier:
eissn:
- 2331-7019
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Fast-driving spectroscopy of current-phase relationships of individual Josephson
elements
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 26
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '23159'
abstract:
- lang: eng
text: The Vera C. Rubin Observatory has now seen first light, and over a 10 year
duration, Legacy Survey of Space and Time (LSST) is projected to catalog tens
of millions of quasars, many of which are expected to be associated with subparsec
supermassive black hole binaries (SMBHBs). Out of these SMBHBs, up to thousands
of relatively massive binary-quasars are expected to exhibit gravitational self-lensing
flares (SLFs) that last for at least 20–30 days. We assess the effectiveness of
the Lomb-Scargle (LS) periodogram and matched filters (MFs) as methods for systematic
searches for these binaries, using toy-models of hydrodynamical, Doppler, and
self-lensing variability from equal-mass, eccentric SMBHBs. We inject SLFs into
random realizations of damped random walk (DRW) lightcurves, representing stochastic
quasar variability, and compute the LS periodogram with and without the SLF. We
find that periodograms of SLF+DRW light-curves do not have maximum peak heights
that could not arise from DRW-only periodograms. On the other hand, the matched
filter signal-to-noise ratio (SNR) can distinguish SLFs from noise even with LSST-like
cadences and DRW noise. Furthermore, we develop a three-step procedure with matched
filters, which can also recover injected binary parameters from these light-curves.
We expect this method to be computationally efficient enough to be applicable
to millions of quasar light-curves in LSST.
acknowledgement: We acknowledge support by NASA Grants No. 80NSSC22K0822 and No. 80NSSC24K0440
(Z. H). V. A. V. acknowledges support through the David and Lucile Packard Foundation,
National Science Foundation under No. PHY-2019786 (The NSF AI Institute for Artificial
Intelligence and Fundamental Interactions, [63]), No. AST-2433718, No. AST-2407922
and No. AST-2406110, as well as an Aramont Fellowship for Emerging Science Research.
J. D. acknowledges support by a joint Columbia/Flatiron Postdoctoral Fellowship.
Research at the Flatiron Institute is supported by the Simons Foundation. This research
was supported in part by the National Science Foundation under Grant No. NSF PHY-1748958
to the Kavli Institute for Theoretical Physics (KITP). This research has made use
of NASA’s Astrophysics Data System. The authors acknowledge the Texas Advanced Computing
Center (TACC) at The University of Texas at Austin for providing computational resources.
V. A. V. acknowledges support through the David and Lucile Packard Foundation, National
Science Foundation under No. AST-2433718, No. AST-2407922 and No. AST-2406110, as
well as an Aramont Fellowship for Emerging Science Research. This work is supported
by the National Science Foundation under Cooperative Agreement No. PHY-2019786 (The
NSF AI Institute for Artificial Intelligence and Fundamental Interactions, [63]).
article_number: '043055'
article_processing_charge: Yes (in subscription journal)
article_type: original
arxiv: 1
author:
- first_name: Kevin S
full_name: Park, Kevin S
id: c0a7603b-66e5-11f0-aaf9-b02edf8b2969
last_name: Park
- first_name: Zoltán
full_name: Haiman, Zoltán
id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
last_name: Haiman
orcid: 0000-0003-3633-5403
- first_name: Chengcheng
full_name: Xin, Chengcheng
last_name: Xin
- first_name: Tzuken
full_name: Shen, Tzuken
last_name: Shen
- first_name: Ashley
full_name: Villar, Ashley
last_name: Villar
- first_name: Jordy
full_name: Davelaar, Jordy
last_name: Davelaar
citation:
ama: Park KS, Haiman Z, Xin C, Shen T, Villar A, Davelaar J. Self-lensing flares
from black hole binaries. V. Systematic searches in LSST. Physical Review D.
2026;113(4). doi:10.1103/p328-62sl
apa: Park, K. S., Haiman, Z., Xin, C., Shen, T., Villar, A., & Davelaar, J.
(2026). Self-lensing flares from black hole binaries. V. Systematic searches in
LSST. Physical Review D. American Physical Society. https://doi.org/10.1103/p328-62sl
chicago: Park, Kevin S, Zoltán Haiman, Chengcheng Xin, Tzuken Shen, Ashley Villar,
and Jordy Davelaar. “Self-Lensing Flares from Black Hole Binaries. V. Systematic
Searches in LSST.” Physical Review D. American Physical Society, 2026.
https://doi.org/10.1103/p328-62sl.
ieee: K. S. Park, Z. Haiman, C. Xin, T. Shen, A. Villar, and J. Davelaar, “Self-lensing
flares from black hole binaries. V. Systematic searches in LSST,” Physical
Review D, vol. 113, no. 4. American Physical Society, 2026.
ista: Park KS, Haiman Z, Xin C, Shen T, Villar A, Davelaar J. 2026. Self-lensing
flares from black hole binaries. V. Systematic searches in LSST. Physical Review
D. 113(4), 043055.
mla: Park, Kevin S., et al. “Self-Lensing Flares from Black Hole Binaries. V. Systematic
Searches in LSST.” Physical Review D, vol. 113, no. 4, 043055, American
Physical Society, 2026, doi:10.1103/p328-62sl.
short: K.S. Park, Z. Haiman, C. Xin, T. Shen, A. Villar, J. Davelaar, Physical Review
D 113 (2026).
das_tickbox: '1'
dataavailabilitystatement: The data are not publicly available. The data are available
from the authors upon reasonable request.
date_created: 2026-10-18T22:01:53Z
date_published: 2026-02-25T00:00:00Z
date_updated: 2026-10-19T08:08:21Z
day: '25'
ddc:
- '520'
department:
- _id: GradSch
- _id: ZoHa
doi: 10.1103/p328-62sl
external_id:
arxiv:
- '2512.08427'
file:
- access_level: open_access
checksum: 764bd6512975216dd63655da64ceeb95
content_type: application/pdf
creator: dernst
date_created: 2026-10-19T08:06:17Z
date_updated: 2026-10-19T08:06:17Z
file_id: '23167'
file_name: 2026_PhysicalReviewD_Park.pdf
file_size: 3535182
relation: main_file
success: 1
file_date_updated: 2026-10-19T08:06:17Z
fulldoi: https://doi.org/10.1103/p328-62sl
has_accepted_license: '1'
intvolume: ' 113'
issue: '4'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
publication: Physical Review D
publication_identifier:
eissn:
- 2470-0029
issn:
- 2470-0010
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Self-lensing flares from black hole binaries. V. Systematic searches in LSST
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 113
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '23155'
abstract:
- lang: eng
text: "In this work we establish several monotonicity and decomposition results
in the framework of random regular graphs. Among other results, we\r\nshow that,
for a wide range of parameters d1 ≤ d2, there exists a coupling of\r\nG(n,d1)
and G(n,d2) satisfying that G(n,d1) ⊆ G(n,d2) with high probability, confirming
a conjecture of Gao, Isaev and McKay in a new regime.\r\nOur contributions include
new tools for analysing contiguity and total variation distance between random
regular graph models, a novel procedure for\r\ngenerating unions of random edge-disjoint
perfect matchings, and refined estimates of Gao’s bounds on the number of perfect
matchings in random regular graphs. In addition, we make progress towards another
conjecture of Isaev,\r\nMcKay, Southwell and Zhukovskii."
acknowledgement: "We are grateful to Béla Bollobás, to Matthew Kwan and to Fabio\r\nToninelli
for their helpful comments and suggestions, and to Nicholas Wormald for useful\r\nremarks
on a preliminary version of this work and pointing us towards the reference [29].\r\nThe
authors would also like to thank several anonymous referees for many useful suggestions,\r\nincluding
pointing out that Lemma 2.10 already appeared in [11].\r\nPart of this research
was done during a visit of the fourth author to IST Austria. We thank\r\nIST Austria
for its hospitality.\r\nFor open access purposes, the authors have applied a CC
BY public copyright license to\r\nany author accepted manuscript version arising
from this submission. L. Hollom was supported by the Internal Graduate Studentship
of Trinity College, Cambridge.\r\nL. Lichev was supported by the Austrian Science
Fund (FWF) grant No. 10.55776/ESP624.\r\nA. Mond was supported by UK Research and
Innovation grant MR/W007320/2. Wang was\r\nsupported by the ERC Starting Grant “RANDSTRUCT”
No. 101076777."
article_processing_charge: Yes (in subscription journal)
article_type: original
arxiv: 1
author:
- first_name: Lawrence
full_name: Hollom, Lawrence
last_name: Hollom
- first_name: Lyuben
full_name: Lichev, Lyuben
id: 9aa8388e-d003-11ee-8458-c4c1d7447977
last_name: Lichev
- first_name: Adva
full_name: Mond, Adva
last_name: Mond
- first_name: Julien
full_name: Portier, Julien
last_name: Portier
- first_name: Yiting
full_name: Wang, Yiting
id: 1917d194-076e-11ed-97cd-837255f88785
last_name: Wang
citation:
ama: Hollom L, Lichev L, Mond A, Portier J, Wang Y. Monotonicity and decompositions
of random regular graphs. Annals of Applied Probability. 2026;36(5):4716-4738.
doi:10.1214/26-AAP2345
apa: Hollom, L., Lichev, L., Mond, A., Portier, J., & Wang, Y. (2026). Monotonicity
and decompositions of random regular graphs. Annals of Applied Probability.
Institute of Mathematical Statistics. https://doi.org/10.1214/26-AAP2345
chicago: Hollom, Lawrence, Lyuben Lichev, Adva Mond, Julien Portier, and Yiting
Wang. “Monotonicity and Decompositions of Random Regular Graphs.” Annals of
Applied Probability. Institute of Mathematical Statistics, 2026. https://doi.org/10.1214/26-AAP2345.
ieee: L. Hollom, L. Lichev, A. Mond, J. Portier, and Y. Wang, “Monotonicity and
decompositions of random regular graphs,” Annals of Applied Probability,
vol. 36, no. 5. Institute of Mathematical Statistics, pp. 4716–4738, 2026.
ista: Hollom L, Lichev L, Mond A, Portier J, Wang Y. 2026. Monotonicity and decompositions
of random regular graphs. Annals of Applied Probability. 36(5), 4716–4738.
mla: Hollom, Lawrence, et al. “Monotonicity and Decompositions of Random Regular
Graphs.” Annals of Applied Probability, vol. 36, no. 5, Institute of Mathematical
Statistics, 2026, pp. 4716–38, doi:10.1214/26-AAP2345.
short: L. Hollom, L. Lichev, A. Mond, J. Portier, Y. Wang, Annals of Applied Probability
36 (2026) 4716–4738.
das_tickbox: '0'
date_created: 2026-10-18T22:01:52Z
date_published: 2026-10-01T00:00:00Z
date_updated: 2026-10-19T07:39:17Z
day: '01'
ddc:
- '500'
department:
- _id: MaKw
- _id: GradSch
doi: 10.1214/26-AAP2345
external_id:
arxiv:
- '2505.22875'
file:
- access_level: open_access
checksum: 46101e61d29cf40f0a204801d15a848f
content_type: application/pdf
creator: dernst
date_created: 2026-10-19T07:33:58Z
date_updated: 2026-10-19T07:33:58Z
file_id: '23165'
file_name: 2026_AnnalsAppliedProbability_Hollom.pdf
file_size: 320593
relation: main_file
success: 1
file_date_updated: 2026-10-19T07:33:58Z
fulldoi: https://doi.org/10.1214/26-AAP2345
has_accepted_license: '1'
intvolume: ' 36'
issue: '5'
keyword:
- Random regular graphs
- coupling
- contiguity
- total variation distance
- decomposition
language:
- iso: eng
mathsc:
- 05C80
month: '10'
oa: 1
oa_version: Published Version
page: 4716-4738
project:
- _id: bd95085b-d553-11ed-ba76-e55d3349be45
grant_number: '101076777'
name: Randomness and structure in combinatorics
- _id: e19fef4c-1f3d-11f0-ac04-b8b1af6886d8
grant_number: E624
name: THRESHOLDS IN SEMI-RANDOM PROCESSES AND GRAPH EMBEDDINGS
publication: Annals of Applied Probability
publication_identifier:
eissn:
- 2168-8737
issn:
- 1050-5164
publication_status: published
publisher: Institute of Mathematical Statistics
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Monotonicity and decompositions of random regular graphs
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 36
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '22012'
abstract:
- lang: eng
text: Single stranded helically folded aromatic oligoamides bearing anionic phosphonate
side chains have been shown to bind to some DNA-binding proteins better than DNA
itself. However, these DNA mimic foldamers have until now mainly consisted of
a single repeat motif, like a poly(dA:dT) DNA duplex, and contained limited sequence
information. Here, we introduce new monomers designed to display different chemical
functionalities in the major groove of the DNA mimics. Four new Fmoc-protected
amino acid monomers have been synthesized and incorporated into oligomers. Sixteen
foldamer sequences were prepared on solid phase. Their conformation in solution
and in the solid state and their conformational dynamics were investigated using
NMR, circular dichroism, molecular modeling, and X-ray crystallography. The results
show that three of four new monomers behaved as designed, and that their introduction
enhances the conformational dynamics of the DNA mimic foldamers. In a fourth case,
conformational behavior proved to be more complex than expected. The modified
sequences retained an ability to bind to bacterial histone-like protein HU. These
results showcase design strategies to manipulate large molecular biomimetics where
not only side chains but also main chain components are varied. The new monomers
pave the way to complex DNA mimic foldamer sequences targeting proteins that recognize
sequence-selective DNA-binding proteins such as transcription factors or restriction
enzymes.
acknowledgement: We acknowledge financial support from the European Research Council
(ERC) under the European Union's Horizon Europe Framework Programme (grant agreement
no. ERC-2021-ADG-320892) and from the China Scholarship Council (CSC, predoctoral
fellowship to J. W.). We thank L. Allmendinger for assistance with NMR measurements,
P. Mayer for his assistance in solving the crystal structures of 1 and 1d, L. Bodero
for assistance with automated solid-phase synthesis, M. Rogovoi for providing monomer
precursors, and M. Loos for the purification and analysis of compounds 15a–19a.
We thank M. Soler-Lopez (ID23-1, ESRF, Grenoble) and I. Bento (EMBL P13, Petra III,
DESY, Hamburg) for assistance during data collection at the synchrotron beamlines.
article_processing_charge: Yes
article_type: original
author:
- first_name: Jiaojiao
full_name: Wu, Jiaojiao
last_name: Wu
- first_name: Valentina
full_name: Corvaglia, Valentina
last_name: Corvaglia
- first_name: Tulika
full_name: Chakrabortty, Tulika
last_name: Chakrabortty
- first_name: Pradeep K
full_name: Mandal, Pradeep K
id: 6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
last_name: Mandal
orcid: 0000-0001-5996-956X
- first_name: Ivan
full_name: Huc, Ivan
last_name: Huc
citation:
ama: Wu J, Corvaglia V, Chakrabortty T, Mandal PK, Huc I. Tailoring the major groove
of DNA mimic foldamers. Chemical Science. 2026;17(32):15479–15489. doi:10.1039/d6sc00798h
apa: Wu, J., Corvaglia, V., Chakrabortty, T., Mandal, P. K., & Huc, I. (2026).
Tailoring the major groove of DNA mimic foldamers. Chemical Science. Royal
Society of Chemistry. https://doi.org/10.1039/d6sc00798h
chicago: Wu, Jiaojiao, Valentina Corvaglia, Tulika Chakrabortty, Pradeep K Mandal,
and Ivan Huc. “Tailoring the Major Groove of DNA Mimic Foldamers.” Chemical
Science. Royal Society of Chemistry, 2026. https://doi.org/10.1039/d6sc00798h.
ieee: J. Wu, V. Corvaglia, T. Chakrabortty, P. K. Mandal, and I. Huc, “Tailoring
the major groove of DNA mimic foldamers,” Chemical Science, vol. 17, no.
32. Royal Society of Chemistry, pp. 15479–15489, 2026.
ista: Wu J, Corvaglia V, Chakrabortty T, Mandal PK, Huc I. 2026. Tailoring the major
groove of DNA mimic foldamers. Chemical Science. 17(32), 15479–15489.
mla: Wu, Jiaojiao, et al. “Tailoring the Major Groove of DNA Mimic Foldamers.” Chemical
Science, vol. 17, no. 32, Royal Society of Chemistry, 2026, pp. 15479–15489,
doi:10.1039/d6sc00798h.
short: J. Wu, V. Corvaglia, T. Chakrabortty, P.K. Mandal, I. Huc, Chemical Science
17 (2026) 15479–15489.
das_tickbox: '1'
dataavailabilitystatement: "CCDC 2514117, 2514118, 2286782 and 2478322 (compound 1,
compound 1d, oligomer 5, and oligomer 6, respectively) contain the supplementary
crystallographic data for this paper.54a–d \r\n\r\nThe supporting data have been
provided as part of the supplementary information (SI). Supplementary information:
SI figures, detailed experimental protocols, crystallographic studies, and characterisation
of new compounds. See DOI: https://doi.org/10.1039/d6sc00798h."
date_created: 2026-06-16T08:04:15Z
date_published: 2026-08-19T00:00:00Z
date_updated: 2026-10-19T08:35:08Z
day: '19'
ddc:
- '540'
department:
- _id: LifeSc
doi: 10.1039/d6sc00798h
external_id:
pmid:
- '42388815'
file:
- access_level: open_access
checksum: fee032060eb71cba73afa8e301b9ee94
content_type: application/pdf
creator: dernst
date_created: 2026-10-19T08:32:00Z
date_updated: 2026-10-19T08:32:00Z
file_id: '23169'
file_name: 2026_ChemicalScience_Wu.pdf
file_size: 1361818
relation: main_file
success: 1
file_date_updated: 2026-10-19T08:32:00Z
fulldoi: https://doi.org/10.1039/d6sc00798h
has_accepted_license: '1'
intvolume: ' 17'
issue: '32'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 15479–15489
pmid: 1
publication: Chemical Science
publication_identifier:
eissn:
- 2041-6539
issn:
- 2041-6520
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Tailoring the major groove of DNA mimic foldamers
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '23153'
abstract:
- lang: eng
text: "We study the renormalized Nelson model in a semiclassical regime where the
field becomes\r\nclassical while the particle remains quantum. The degree of classicality
is measured by a\r\nsmall parameter ε << 1. In this scaling the particle evolves
on microscopic times, whereas\r\nthe field exhibits nontrivial dynamics only on
the macroscopic scale t = O(ε^−2). The natural\r\nsemiclassical model is the coupled
Schrödinger–Klein–Gordon (SKG) system, which\r\nencodes the time-scale separation
through an explicit ε-dependence. Based on this scale separation\r\nin SKG, we
apply the adiabatic principle to derive a new PDE for the classical field,\r\nthe
ε-free adiabatic Klein–Gordon (aKG) equation, where the field is driven by the
instantaneous\r\nground state of the particle. Our main result is a norm approximation
of the Nelson\r\ndynamics by the aKGsolution corrected by a quasi-free fluctuation
dynamics around the classical\r\nfield, generated by a renormalized Bogoliubov–Nelson
Hamiltonian. As a corollary, we\r\nobtain convergence of the reduced one-body
densities for both subsystems, where the fluctuation\r\ncorrection vanishes, thereby
justifying aKG as a semiclassical Born–Oppenheimer\r\ntype approximation of the
renormalized Nelson model."
acknowledgement: Morris Brooks gratefully acknowledges support from the ERC Advanced
Grant CLaQS, grant agreement No. 834782. Open access funding provided by University
of Zurich.
article_number: '270'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Morris
full_name: Brooks, Morris
id: B7ECF9FC-AA38-11E9-AC9A-0930E6697425
last_name: Brooks
orcid: 0000-0002-6249-0928
- first_name: David Johannes
full_name: Mitrouskas, David Johannes
id: cbddacee-2b11-11eb-a02e-a2e14d04e52d
last_name: Mitrouskas
citation:
ama: Brooks M, Mitrouskas DJ. Adiabatic Klein–Gordon dynamics for the renormalized
Nelson model. Calculus of Variations and Partial Differential Equations.
2026;65(10). doi:10.1007/s00526-026-03436-9
apa: Brooks, M., & Mitrouskas, D. J. (2026). Adiabatic Klein–Gordon dynamics
for the renormalized Nelson model. Calculus of Variations and Partial Differential
Equations. Springer. https://doi.org/10.1007/s00526-026-03436-9
chicago: Brooks, Morris, and David Johannes Mitrouskas. “Adiabatic Klein–Gordon
Dynamics for the Renormalized Nelson Model.” Calculus of Variations and Partial
Differential Equations. Springer, 2026. https://doi.org/10.1007/s00526-026-03436-9.
ieee: M. Brooks and D. J. Mitrouskas, “Adiabatic Klein–Gordon dynamics for the renormalized
Nelson model,” Calculus of Variations and Partial Differential Equations,
vol. 65, no. 10. Springer, 2026.
ista: Brooks M, Mitrouskas DJ. 2026. Adiabatic Klein–Gordon dynamics for the renormalized
Nelson model. Calculus of Variations and Partial Differential Equations. 65(10),
270.
mla: Brooks, Morris, and David Johannes Mitrouskas. “Adiabatic Klein–Gordon Dynamics
for the Renormalized Nelson Model.” Calculus of Variations and Partial Differential
Equations, vol. 65, no. 10, 270, Springer, 2026, doi:10.1007/s00526-026-03436-9.
short: M. Brooks, D.J. Mitrouskas, Calculus of Variations and Partial Differential
Equations 65 (2026).
das_tickbox: '1'
dataavailabilitystatement: No data are associated with this article.
date_created: 2026-10-18T22:01:52Z
date_published: 2026-10-01T00:00:00Z
date_updated: 2026-10-19T07:55:13Z
day: '01'
ddc:
- '500'
department:
- _id: RoSe
doi: 10.1007/s00526-026-03436-9
external_id:
arxiv:
- '2509.14226'
pmid:
- '42865432'
file:
- access_level: open_access
checksum: 406bc9d144c35c9485d277c842d38c36
content_type: application/pdf
creator: dernst
date_created: 2026-10-19T07:53:14Z
date_updated: 2026-10-19T07:53:14Z
file_id: '23166'
file_name: 2026_CalculusVariations_Brooks.pdf
file_size: 905142
relation: main_file
success: 1
file_date_updated: 2026-10-19T07:53:14Z
fulldoi: https://doi.org/10.1007/s00526-026-03436-9
has_accepted_license: '1'
intvolume: ' 65'
issue: '10'
language:
- iso: eng
mathsc:
- 81Q05
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
publication: Calculus of Variations and Partial Differential Equations
publication_identifier:
eissn:
- 1432-0835
issn:
- 0944-2669
publication_status: published
publisher: Springer
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Adiabatic Klein–Gordon dynamics for the renormalized Nelson model
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 65
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '23157'
abstract:
- lang: eng
text: The concept of Culture of Care fosters a research environment where lab animals
and humans are cared for and respected. Several aspects, such as perception of
suffering, time, perceived value of an animal, potential benefits of the research,
and public opinion, might influence care for animals. The European Directive 2010/63/EU
on the protection of animals used for scientific purposes has represented an advance
in animal welfare standards and care. However, the question of how we care about
animals in practice, and of why this debate is important to reflect on still exist.
Therefore, we draw upon the case study of laboratory non-human primates, to illustrate
how these tensions go from theory to practice. It illustrates the conflicts and
emotions, by exposing the limitations of the standards and norms in the field.
Debating care requires a more comprehensive notion of care, one that goes beyond
normative decisions to enable care in practice.
acknowledgement: "This publication is based upon work from the Ethics Crossover Group
within the cost Action improve (“3Rs concepts to improve the quality of biomedical
science”), ca21139, supported by cost (European Cooperation in Science and Technology).\r\nWe
sincerely thank Nuno Franco for critical reviewing the manuscript.\r\nWe acknowledge
support by Open Access Publishing Fund of Karl Landsteiner University, Krems, Austria."
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Sophie
full_name: Schober, Sophie
id: 80b0a0ef-4b9f-11ec-b119-8d9d94c4a1d8
last_name: Schober
- first_name: Augusto
full_name: Vitale, Augusto
last_name: Vitale
- first_name: Brigida
full_name: Riso, Brigida
last_name: Riso
citation:
ama: 'Schober S, Vitale A, Riso B. How we care about laboratory animals: Acknowledging
differences towards a more comprehensive concept of caring. Journal of Applied
Animal Ethics Research. 2026;8(1):88-104. doi:10.1163/25889567-bja10078'
apa: 'Schober, S., Vitale, A., & Riso, B. (2026). How we care about laboratory
animals: Acknowledging differences towards a more comprehensive concept of caring.
Journal of Applied Animal Ethics Research. Brill Academic Publishers. https://doi.org/10.1163/25889567-bja10078'
chicago: 'Schober, Sophie, Augusto Vitale, and Brigida Riso. “How We Care about
Laboratory Animals: Acknowledging Differences towards a More Comprehensive Concept
of Caring.” Journal of Applied Animal Ethics Research. Brill Academic Publishers,
2026. https://doi.org/10.1163/25889567-bja10078.'
ieee: 'S. Schober, A. Vitale, and B. Riso, “How we care about laboratory animals:
Acknowledging differences towards a more comprehensive concept of caring,” Journal
of Applied Animal Ethics Research, vol. 8, no. 1. Brill Academic Publishers,
pp. 88–104, 2026.'
ista: 'Schober S, Vitale A, Riso B. 2026. How we care about laboratory animals:
Acknowledging differences towards a more comprehensive concept of caring. Journal
of Applied Animal Ethics Research. 8(1), 88–104.'
mla: 'Schober, Sophie, et al. “How We Care about Laboratory Animals: Acknowledging
Differences towards a More Comprehensive Concept of Caring.” Journal of Applied
Animal Ethics Research, vol. 8, no. 1, Brill Academic Publishers, 2026, pp.
88–104, doi:10.1163/25889567-bja10078.'
short: S. Schober, A. Vitale, B. Riso, Journal of Applied Animal Ethics Research
8 (2026) 88–104.
das_tickbox: '0'
date_created: 2026-10-18T22:01:53Z
date_published: 2026-09-01T00:00:00Z
date_updated: 2026-10-19T08:28:37Z
day: '01'
ddc:
- '570'
department:
- _id: PreCl
doi: 10.1163/25889567-bja10078
file:
- access_level: open_access
checksum: a148db5e47af7cbfccaecf8cec0beff6
content_type: application/pdf
creator: dernst
date_created: 2026-10-19T08:25:17Z
date_updated: 2026-10-19T08:25:17Z
file_id: '23168'
file_name: 2026_JourAppliedAnimalEthicsResearch_Schober.pdf
file_size: 464277
relation: main_file
success: 1
file_date_updated: 2026-10-19T08:25:17Z
fulldoi: https://doi.org/10.1163/25889567-bja10078
has_accepted_license: '1'
intvolume: ' 8'
issue: '1'
keyword:
- culture of care
- culture of care in practice
- lab animals
- interspecies relationships
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 88-104
publication: Journal of Applied Animal Ethics Research
publication_identifier:
eissn:
- 2588-9567
issn:
- 2588-9559
publication_status: published
publisher: Brill Academic Publishers
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: 'How we care about laboratory animals: Acknowledging differences towards a
more comprehensive concept of caring'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '23158'
abstract:
- lang: eng
text: For a tree T and a function f:E(T)→Sd, the imbalance of a subtree T′⊆T is
given by |∑e∈E(T′)f(e)|. The d-dimensional discrepancy of the tree T is the minimum,
over all functions f as above, of the maximum imbalance of a subtree of T. We
prove tight asymptotic bounds for the discrepancy of a tree T, confirming a conjecture
of Krishna, Michaeli, Sarantis, Wang and Wang. We also settle a related conjecture
on oriented discrepancy of subtrees by the same authors.
acknowledgement: The authors would like to thank both Béla Bollobás and the anonymous
reviewer for their careful readings of the manuscript and for their valuable comments.
The first author was funded by Trinity College, Cambridge. The second author was
funded in whole or in part by the Austrian Science Fund (FWF) 10.55776/ESP624. The
third author was supported by UK Research and Innovation grant MR/W007320/2. The
fourth author was funded by EPSRC (Engineering and Physical Sciences Research Council)
and by the Cambridge Commonwealth, European and International Trust.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Lawrence
full_name: Hollom, Lawrence
last_name: Hollom
- first_name: Lyuben
full_name: Lichev, Lyuben
id: 9aa8388e-d003-11ee-8458-c4c1d7447977
last_name: Lichev
- first_name: Adva
full_name: Mond, Adva
last_name: Mond
- first_name: Julien
full_name: Portier, Julien
last_name: Portier
citation:
ama: Hollom L, Lichev L, Mond A, Portier J. A note on high-dimensional discrepancy
of subtrees. Discrete and Computational Geometry. 2026. doi:10.1007/s00454-025-00790-x
apa: Hollom, L., Lichev, L., Mond, A., & Portier, J. (2026). A note on high-dimensional
discrepancy of subtrees. Discrete and Computational Geometry. Springer.
https://doi.org/10.1007/s00454-025-00790-x
chicago: Hollom, Lawrence, Lyuben Lichev, Adva Mond, and Julien Portier. “A Note
on High-Dimensional Discrepancy of Subtrees.” Discrete and Computational Geometry.
Springer, 2026. https://doi.org/10.1007/s00454-025-00790-x.
ieee: L. Hollom, L. Lichev, A. Mond, and J. Portier, “A note on high-dimensional
discrepancy of subtrees,” Discrete and Computational Geometry. Springer,
2026.
ista: Hollom L, Lichev L, Mond A, Portier J. 2026. A note on high-dimensional discrepancy
of subtrees. Discrete and Computational Geometry.
mla: Hollom, Lawrence, et al. “A Note on High-Dimensional Discrepancy of Subtrees.”
Discrete and Computational Geometry, Springer, 2026, doi:10.1007/s00454-025-00790-x.
short: L. Hollom, L. Lichev, A. Mond, J. Portier, Discrete and Computational Geometry
(2026).
das_tickbox: '1'
dataavailabilitystatement: Data sharing not applicable to this article as no datasets
were generated or analysed during the current study.
date_created: 2026-10-18T22:01:53Z
date_published: 2026-10-09T00:00:00Z
date_updated: 2026-10-19T08:20:42Z
day: '09'
department:
- _id: MaKw
doi: 10.1007/s00454-025-00790-x
external_id:
arxiv:
- '2412.04170'
fulldoi: https://doi.org/10.1007/s00454-025-00790-x
keyword:
- Trees
- High-dimensional discrepancy
- Oriented discrepancy
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2412.04170
mathsc:
- 05C05
- 05C35
- 11K38
month: '10'
oa: 1
oa_version: Preprint
project:
- _id: e19fef4c-1f3d-11f0-ac04-b8b1af6886d8
grant_number: E624
name: THRESHOLDS IN SEMI-RANDOM PROCESSES AND GRAPH EMBEDDINGS
publication: Discrete and Computational Geometry
publication_identifier:
eissn:
- 1432-0444
issn:
- 0179-5376
publication_status: epub_ahead
publisher: Springer
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: A note on high-dimensional discrepancy of subtrees
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '23171'
abstract:
- lang: eng
text: Crawling motility is a hallmark of eukaryotic cells and requires a dynamic
actin cytoskeleton, regulated adhesion and spatially organized signalling pathways1,2.
Asgard archaea, which are considered the closest known prokaryotic relatives of
eukaryotes, potentially encode these functions within their large set of ‘eukaryotic
signature proteins’3,4,5,6. The few cultivated members show a complex cell morphology,
consisting of a central cell body from which several protrusions extend, filled
with an actin-based cytoskeleton7,8. Here, live-cell microscopy of two organisms
of the Lokiarchaea and Hodarchaea lineages7,9 showed that they dynamically and
greatly change their cell shape on a minute time scale and grow and retract their
extensive protrusions with a speed of 1.5–4.8 µm min−1, respectively. After adhering
to a glass surface, cells use their protrusions to undergo active crawling motion.
In the presence of selected actin inhibitors, however, the observed dynamics were
arrested, suggesting a central role of actin in these processes. The observed
cellular plasticity and motility are unique features among prokaryotes and might
have been crucial for the emergence of the first eukaryotic cells that are thought
to have formed through the association of a member of the Asgard archaea and an
α-proteobacterium, the ancestor of mitochondria.
acknowledged_ssus:
- _id: Bio
acknowledgement: This work would not have been possible without the technical support
in cultivation from K. Hager, F. Baraket, A. Malits and S. Harrer. We thank the
Imaging and Optics Facility (IOF) at ISTA for their help in setting up the anaerobic
environment during imaging and the Cell Imaging & Ultrastructure Research (CIUS)
facility at the University of Vienna for their support. Proteomics analyses were
performed by the Mass Spectrometry Facility at Max Perutz Labs using the VBCF instrument
pool. We also thank P. Klahn (University of Gothenburg, Sweden), M. Stadler and
members of his department (HZI Braunschweig) as well as R. Cox (LUH Hannover) for
providing different cytochalasans and P. Bieling (King’s College London) for discussion.
Most of this work was funded by the Austrian Science Fund (FWF) with grant DOI 10.55776/Z437
(available at https://doi.org/10.55776/Z437) and further supported by an emerging
field grant with grant DOI 10.55776/EFP25 (available at https://doi.org/10.55776/EFP25)
to C.S. For open access purposes, the author has applied a CC BY public copyright
license to any author accepted manuscript version arising from this submission.
This work was further supported by a European Research Council grant ERC-SyG (101071793)
to M.S., by the German Research Council through the CytoLabs consortium (Research
Unit 5170 to K.R. and T.E.B.S.), by the Japan Society for the Promotion of Science
Grant-in-Aid for Scientific Research 22H04985 to H.I. and M.N. Furthermore, R.H.
was supported by CZI grant DAF2020-225401 and a grant (https://doi.org/10.37921/120055ratwvi)
from the Chan Zuckerberg Initiative DAF. Open access funding provided by University
of Vienna.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Philipp
full_name: Radler, Philipp
id: 40136C2A-F248-11E8-B48F-1D18A9856A87
last_name: Radler
orcid: '0000-0001-9198-2182 '
- first_name: Tobias
full_name: Viehboeck, Tobias
last_name: Viehboeck
- first_name: Zhen-Hao
full_name: Luo, Zhen-Hao
last_name: Luo
- first_name: Nevena
full_name: Maslać, Nevena
last_name: Maslać
- first_name: Katharina
full_name: Schmidt, Katharina
last_name: Schmidt
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Masaru K.
full_name: Nobu, Masaru K.
last_name: Nobu
- first_name: Silvia
full_name: Bulgheresi, Silvia
last_name: Bulgheresi
- first_name: Theresia E. B.
full_name: Stradal, Theresia E. B.
last_name: Stradal
- first_name: Klemens
full_name: Rottner, Klemens
last_name: Rottner
- first_name: Hiroyuki
full_name: Imachi, Hiroyuki
last_name: Imachi
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Christa
full_name: Schleper, Christa
last_name: Schleper
citation:
ama: Radler P, Viehboeck T, Luo Z-H, et al. Dynamic protrusions mediate crawling
motility in Asgard archaea. Nature. 2026. doi:10.1038/s41586-026-11063-9
apa: Radler, P., Viehboeck, T., Luo, Z.-H., Maslać, N., Schmidt, K., Hauschild,
R., … Schleper, C. (2026). Dynamic protrusions mediate crawling motility in Asgard
archaea. Nature. Springer Nature. https://doi.org/10.1038/s41586-026-11063-9
chicago: Radler, Philipp, Tobias Viehboeck, Zhen-Hao Luo, Nevena Maslać, Katharina
Schmidt, Robert Hauschild, Masaru K. Nobu, et al. “Dynamic Protrusions Mediate
Crawling Motility in Asgard Archaea.” Nature. Springer Nature, 2026. https://doi.org/10.1038/s41586-026-11063-9.
ieee: P. Radler et al., “Dynamic protrusions mediate crawling motility in
Asgard archaea,” Nature. Springer Nature, 2026.
ista: Radler P, Viehboeck T, Luo Z-H, Maslać N, Schmidt K, Hauschild R, Nobu MK,
Bulgheresi S, Stradal TEB, Rottner K, Imachi H, Sixt MK, Schleper C. 2026. Dynamic
protrusions mediate crawling motility in Asgard archaea. Nature.
mla: Radler, Philipp, et al. “Dynamic Protrusions Mediate Crawling Motility in Asgard
Archaea.” Nature, Springer Nature, 2026, doi:10.1038/s41586-026-11063-9.
short: P. Radler, T. Viehboeck, Z.-H. Luo, N. Maslać, K. Schmidt, R. Hauschild,
M.K. Nobu, S. Bulgheresi, T.E.B. Stradal, K. Rottner, H. Imachi, M.K. Sixt, C.
Schleper, Nature (2026).
das_tickbox: '1'
dataavailabilitystatement: The plots in this manuscript were created using Jupyter
Notebook; the source data for all figures have been provided in data source tables.
Microscopy raw data for supplementary videos, the Jupyter notebooks to generate
the plots and the raw files for the structural phylogenetic analysis are available
at https://doi.org/10.6084/m9.figshare.30676367. The remaining raw microscopy data
generated for this manuscript are available from https://www.ebi.ac.uk/biostudies/bioimages/studies/S-BIAD3928.
The mass spectrometry proteomics data from the Co-IP experiments have been deposited
to the ProteomeXchange Consortium via the PRIDE partner repository79 and are available
at https://www.ebi.ac.uk/pride/archive/projects/PXD068820. The mass spectrometry
proteomics data of the proteome analysis is available at https://www.ebi.ac.uk/pride/archive/projects/PXD074767.
Source data are provided with this paper.
date_created: 2026-10-19T09:26:53Z
date_published: 2026-09-30T00:00:00Z
date_updated: 2026-10-19T09:40:50Z
day: '30'
ddc:
- '570'
department:
- _id: MiSi
- _id: Bio
doi: 10.1038/s41586-026-11063-9
external_id:
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fulldoi: https://doi.org/10.1038/s41586-026-11063-9
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language:
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main_file_link:
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url: https://doi.org/10.1038/s41586-026-11063-9
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: bd91e723-d553-11ed-ba76-fe7eeb2185fd
grant_number: '101071793'
name: 'Pushing from within: Control of cell shape, integrity and motility by cytoskeletal
pushing forces'
- _id: c08e9ad1-5a5b-11eb-8a69-9d1cf3b07473
grant_number: CZI01
name: Tools for automation and feedback microscopy
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Dynamic protrusions mediate crawling motility in Asgard archaea
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '22622'
abstract:
- lang: eng
text: Cooperative software verification aims at improving the effectiveness and
efficiency of software verification by enabling multiple verification tools to
work together. Existing cooperative verification schemes, however, typically require
specialized interfaces or tight integration, limiting their practical applicability.
In our International Conference on Software Engineering (ICSE) 2025 publication,
we introduce dynamic program splitting – a novel approach that enables cooperation
between off-the-shelf verification tools without requiring any modifications.
The key idea is to probe verification tools on a given verification task under
a time limit and split tasks dynamically that cannot be verified under the given
time constraints. The process continues recursively, incrementally identifying
program parts that are particularly hard for the given verifier. The remaining
unverified parts are provided to a second verifier, allowing to leverage the complementary
strengths of different tools. Our evaluation on SV-COMP benchmarks demonstrates
that cooperation through dynamic program splitting enables the verification of
tasks that none of the individual verifiers can solve on their own.
alternative_title:
- Lecture Notes in Informatics
article_processing_charge: No
author:
- first_name: Cedric
full_name: Richter, Cedric
last_name: Richter
- first_name: Marek
full_name: Chalupa, Marek
id: 87e34708-d6c6-11ec-9f5b-9391e7be2463
last_name: Chalupa
- first_name: Marie Christine
full_name: Jakobs, Marie Christine
last_name: Jakobs
- first_name: Heike
full_name: Wehrheim, Heike
last_name: Wehrheim
citation:
ama: 'Richter C, Chalupa M, Jakobs MC, Wehrheim H. Off-the-Shelf cooperative software
verification by splitting programs dynamically. In: Software Engineering 2026.
Vol P-377. Gesellschaft für Informatik; 2026:41-42. doi:10.18420/se2026_45'
apa: 'Richter, C., Chalupa, M., Jakobs, M. C., & Wehrheim, H. (2026). Off-the-Shelf
cooperative software verification by splitting programs dynamically. In Software
Engineering 2026 (Vol. P-377, pp. 41–42). Bonn, Switzerland: Gesellschaft
für Informatik. https://doi.org/10.18420/se2026_45'
chicago: Richter, Cedric, Marek Chalupa, Marie Christine Jakobs, and Heike Wehrheim.
“Off-the-Shelf Cooperative Software Verification by Splitting Programs Dynamically.”
In Software Engineering 2026, P-377:41–42. Gesellschaft für Informatik,
2026. https://doi.org/10.18420/se2026_45.
ieee: C. Richter, M. Chalupa, M. C. Jakobs, and H. Wehrheim, “Off-the-Shelf cooperative
software verification by splitting programs dynamically,” in Software Engineering
2026, Bonn, Switzerland, 2026, vol. P-377, pp. 41–42.
ista: 'Richter C, Chalupa M, Jakobs MC, Wehrheim H. 2026. Off-the-Shelf cooperative
software verification by splitting programs dynamically. Software Engineering
2026. SE: Software Engineering, Lecture Notes in Informatics, vol. P-377, 41–42.'
mla: Richter, Cedric, et al. “Off-the-Shelf Cooperative Software Verification by
Splitting Programs Dynamically.” Software Engineering 2026, vol. P-377,
Gesellschaft für Informatik, 2026, pp. 41–42, doi:10.18420/se2026_45.
short: C. Richter, M. Chalupa, M.C. Jakobs, H. Wehrheim, in:, Software Engineering
2026, Gesellschaft für Informatik, 2026, pp. 41–42.
conference:
end_date: 2026-02-27
location: Bonn, Switzerland
name: 'SE: Software Engineering'
start_date: 2026-02-23
das_tickbox: '1'
dataavailabilitystatement: "All our implementations and data are archived and available
at Zenodo5\r\nand are evaluated as an artifact in the ICSE 2025 artifact evaluation.
Furthermore, our\r\napproach is integrated into the software verifier Bubaak [CR25]
which we submitted as\r\npart of our contribution to SV-COMP 2025."
date_created: 2026-08-02T22:01:54Z
date_published: 2026-03-01T00:00:00Z
date_updated: 2026-10-19T08:49:32Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.18420/se2026_45
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content_type: application/pdf
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date_created: 2026-10-19T08:39:37Z
date_updated: 2026-10-19T08:39:37Z
file_id: '23170'
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relation: main_file
success: 1
file_date_updated: 2026-10-19T08:39:37Z
fulldoi: https://doi.org/10.18420/se2026_45
has_accepted_license: '1'
keyword:
- Software Verification
- Cooperation
- Program Decomposition
language:
- iso: eng
license: https://creativecommons.org/licenses/by-sa/4.0/
month: '03'
oa: 1
oa_version: Published Version
page: 41-42
publication: Software Engineering 2026
publication_identifier:
eissn:
- 1617-5468
publication_status: published
publisher: Gesellschaft für Informatik
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
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supplementarymaterial: no
title: Off-the-Shelf cooperative software verification by splitting programs dynamically
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legal_code_url: https://creativecommons.org/licenses/by-sa/4.0/legalcode
name: Creative Commons Attribution-ShareAlike 4.0 International Public License (CC
BY-SA 4.0)
short: CC BY-SA (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: P-377
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '23173'
abstract:
- lang: eng
text: The prevalence of proline residues in intrinsically disordered proteins, functional
hinges of enzymes, and protein interaction sites highlights the importance of
studying their local dynamics and interactions at atomic resolution. While nuclear
magnetic resonance (NMR) spectroscopy is, in principle, ideally suited for such
investigations, the absence of an amide proton precludes the use of conventional
1H–15N amide-detected experiments. 1H–13C-based approaches, though possible, remain
challenging in large proteins. In this work, we present a selective labeling strategy
that introduces an isolated 1H2δ–13Cδ–15N spin system in proline residues in otherwise
deuterated proteins. Our method leverages the enzymatic conversion of ornithine,
synthesized from cost-effective isotopic precursors. We demonstrate the utility
of this approach by applying it to a 134 kDa enzyme using magic-angle spinning
NMR, highlighting its potential to efficiently probe functionally relevant sites
in proteins.
acknowledged_ssus:
- _id: NMR
- _id: LifeSc
acknowledgement: We thank Undina Guillerm, Rajkumar Singh and Anna Kapitonova for
help with protein production. We are grateful to Dominique Madern for discussions
and for providing the plasmid of IiMDH. We acknowledge the Scientific Service Units
(SSU) of the Institute of Science and Technology Austria (ISTA) through resources
provided by the NMR Facility and the Lab Support Facility, as well as the NMR centre
and MS centre of the University of Vienna. This work was supported by the Austrian
Science Fund (FWF; project number I5812-B) through a French-Austrian binational
research project, as well as by the L’Oréal-UNESCO For Women in Science Fellowship,
awarded in cooperation with the Austrian Academy of Sciences (ÖAW) and the Austrian
Commission for UNESCO.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Darja
full_name: Rohden, Darja
id: 81dc668a-19fa-11f0-bf31-d56534059ef3
last_name: Rohden
- first_name: Federico
full_name: Napoli, Federico
id: d42e08e7-f4fc-11eb-af0a-d71e26138f1b
last_name: Napoli
orcid: 0000-0002-9043-136X
- first_name: Roman J.
full_name: Lichtenecker, Roman J.
last_name: Lichtenecker
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
citation:
ama: Rohden D, Napoli F, Lichtenecker RJ, Schanda P. Chemoenzymatic proline isotope
labeling for solution and magic-angle spinning protein nuclear magnetic resonance.
ACS Chemical Biology. 2026. doi:10.1021/acschembio.6c00587
apa: Rohden, D., Napoli, F., Lichtenecker, R. J., & Schanda, P. (2026). Chemoenzymatic
proline isotope labeling for solution and magic-angle spinning protein nuclear
magnetic resonance. ACS Chemical Biology. American Chemical Society. https://doi.org/10.1021/acschembio.6c00587
chicago: Rohden, Darja, Federico Napoli, Roman J. Lichtenecker, and Paul Schanda.
“Chemoenzymatic Proline Isotope Labeling for Solution and Magic-Angle Spinning
Protein Nuclear Magnetic Resonance.” ACS Chemical Biology. American Chemical
Society, 2026. https://doi.org/10.1021/acschembio.6c00587.
ieee: D. Rohden, F. Napoli, R. J. Lichtenecker, and P. Schanda, “Chemoenzymatic
proline isotope labeling for solution and magic-angle spinning protein nuclear
magnetic resonance,” ACS Chemical Biology. American Chemical Society, 2026.
ista: Rohden D, Napoli F, Lichtenecker RJ, Schanda P. 2026. Chemoenzymatic proline
isotope labeling for solution and magic-angle spinning protein nuclear magnetic
resonance. ACS Chemical Biology.
mla: Rohden, Darja, et al. “Chemoenzymatic Proline Isotope Labeling for Solution
and Magic-Angle Spinning Protein Nuclear Magnetic Resonance.” ACS Chemical
Biology, American Chemical Society, 2026, doi:10.1021/acschembio.6c00587.
short: D. Rohden, F. Napoli, R.J. Lichtenecker, P. Schanda, ACS Chemical Biology
(2026).
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: "Supporting Information is available free of charge at
https://pubs.acs.org/10.1021/acschembio.6c00587.\r\n\r\nDetailed description of
experimental methods; spectra supporting the residue assignment for IiMDH; relaxation
analysis of IiMDH proline-Cδ sites; NMR spectra of isolated [13Cδ,15N,2Hβγ4]-Pro
(PDF)"
date_created: 2026-10-19T11:12:28Z
date_published: 2026-10-13T00:00:00Z
date_updated: 2026-10-19T11:20:33Z
day: '13'
ddc:
- '540'
department:
- _id: PaSc
- _id: GradSch
doi: 10.1021/acschembio.6c00587
external_id:
pmid:
- '42863127'
fulldoi: https://doi.org/10.1021/acschembio.6c00587
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1021/acschembio.6c00587
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: eb9c82eb-77a9-11ec-83b8-aadd536561cf
grant_number: I05812
name: AlloSpace. The emergence and mechanisms of allostery
publication: ACS Chemical Biology
publication_identifier:
eissn:
- 1554-8937
issn:
- 1554-8929
publication_status: epub_ahead
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Chemoenzymatic proline isotope labeling for solution and magic-angle spinning
protein nuclear magnetic resonance
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
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OA_place: publisher
OA_type: diamond
PlanS_conform: '1'
_id: '23046'
abstract:
- lang: eng
text: Most stars form in dense stellar environments, where frequent close encounters
can strongly perturb and reshape the early architecture of planetary systems.
The Solar System, with its rich population of distant comets, provides a natural
laboratory to study these processes. We performed detailed numerical simulations
using the LonelyPlanets framework that combines NBODY6++GPU and REBOUND to explore
the evolution of debris disks around Solar System analogues embedded in stellar
clusters. Two initial configurations are considered, the Extended model and the
Compact model, each containing four giant planets and either an extended or compact
debris disk. We find that compact disks primarily form Kuiper belt and scattered
disk-like populations through planet–disk interactions, while extended disks are
more strongly shaped by stellar encounters, producing Oort cloud-like structures
and interstellar comets with ejection velocities of 1–3 km s−1. Stellar perturbations
are most effective for encounter inclinations between 0° and 30°, giving rise
to distinct dynamical populations, like Sednoids, and inner Oort cloud analogues,
and a characteristic tail in semimajor axis-eccentricity space. In coplanar encounters,
the disk remains largely flattened, whereas polar flybys redistribute angular
momentum vertically, producing nearly isotropic outer populations that resemble
an emerging Oort cloud. Our results suggest that cometary reservoirs and interstellar
objects are natural byproducts of planet–disk interactions and stellar flybys
in dense clusters, linking the architecture of outer planetary systems to their
birth environments.
acknowledgement: "We thank the referee for their suggestions and comments,\r\nwhich
helped us improve the quality and clarity of the paper. S.T. thanks\r\nYlva Götberg,
Maxwell Cai, Diptajyoti Mukherjee, Simon Portegies Zwart, and\r\nAnthony Brown for
their valuable feedback and comments. S.T. acknowledges\r\nthe funding from the
European Union’s Horizon 2020 research and innovation\r\nprogram under the Marie
Skłodowska-Curie grant agreement No 101034413."
article_number: A301
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Santiago
full_name: Torres Rodriguez, Santiago
id: a8df4360-4328-11ee-8f1a-e502d0c83fc2
last_name: Torres Rodriguez
orcid: 0000-0002-3150-8988
citation:
ama: Torres Rodriguez S. Implications for the formation of Oort cloud-like structures
and interstellar comets in dense environments. Astronomy & Astrophysics.
2026;708. doi:10.1051/0004-6361/202554978
apa: Torres Rodriguez, S. (2026). Implications for the formation of Oort cloud-like
structures and interstellar comets in dense environments. Astronomy & Astrophysics.
EDP Sciences. https://doi.org/10.1051/0004-6361/202554978
chicago: Torres Rodriguez, Santiago. “Implications for the Formation of Oort Cloud-like
Structures and Interstellar Comets in Dense Environments.” Astronomy &
Astrophysics. EDP Sciences, 2026. https://doi.org/10.1051/0004-6361/202554978.
ieee: S. Torres Rodriguez, “Implications for the formation of Oort cloud-like structures
and interstellar comets in dense environments,” Astronomy & Astrophysics,
vol. 708. EDP Sciences, 2026.
ista: Torres Rodriguez S. 2026. Implications for the formation of Oort cloud-like
structures and interstellar comets in dense environments. Astronomy & Astrophysics.
708, A301.
mla: Torres Rodriguez, Santiago. “Implications for the Formation of Oort Cloud-like
Structures and Interstellar Comets in Dense Environments.” Astronomy &
Astrophysics, vol. 708, A301, EDP Sciences, 2026, doi:10.1051/0004-6361/202554978.
short: S. Torres Rodriguez, Astronomy & Astrophysics 708 (2026).
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: Movies associated with Figs. 3 and 9 are available at https://www.aanda.org
date_created: 2026-10-04T22:01:54Z
date_published: 2026-04-01T00:00:00Z
date_updated: 2026-10-20T08:14:04Z
day: '01'
ddc:
- '520'
department:
- _id: LiBu
doi: 10.1051/0004-6361/202554978
ec_funded: 1
external_id:
arxiv:
- '2510.23653'
file:
- access_level: open_access
checksum: 3ea1c5f0fabaa005a4aac7e46f4b6d9c
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creator: dernst
date_created: 2026-10-07T12:22:19Z
date_updated: 2026-10-07T12:22:19Z
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has_accepted_license: '1'
intvolume: ' 708'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: Astronomy & Astrophysics
publication_identifier:
eissn:
- 1432-0746
issn:
- 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
researchdata_availability: no
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status: public
supplementarymaterial: no
title: Implications for the formation of Oort cloud-like structures and interstellar
comets in dense environments
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 708
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '22306'
abstract:
- lang: eng
text: "The AP3 complex mediates cargo sorting and carrier assembly for the trafficking
of transmembrane proteins from endosomes to lysosomes. AP3 is generally believed
to localize to clathrin-free, ARF1-positive, elongated carriers in cells, but
the architecture of AP3-based coats was unknown. Using in vitro reconstitution
and cryo–electron tomography, we demonstrate that AP3:ARF1 spontaneously remodels
membranes containing cargo and the phosphoinositide PI(3,5)P\r\n 2\r\n
\ into tubular structures coated in spiraling rows of AP3 arches
and ARF1 dimers. Targeted point mutations disrupting critical AP3:ARF1 and AP3:AP3
lattice interfaces disrupt AP3 recruitment, carrier formation, and lysosomal cargo
trafficking in cells. We propose that AP3 generates tubular carriers on endosomes
by organizing ARF1 dimers into elongated membrane-deforming arrays while simultaneously
selecting cargo. By demonstrating that AP3:ARF1 can generate carriers without
using a clathrin lattice, we explain the clathrin independence of AP3-mediated
trafficking."
acknowledgement: "We thank P. Luzio, N. Bright, and M. S. Robinson for helpful discussions;\r\nJ.
Stacey and Y. Fujiharu for technical discussions and assistance; F. Beck for assistance
with\r\ncomputing infrastructure; and M. Riggi for discussion of data presentation
and figure design.\r\nCryo-E\r\nM data was collected at the Department of Cell and
Virus Structure, Max Planck Institute\r\nof Biochemistry. Funding: This work was
funded by: the Wellcome Trust, Wellcome Discovery\r\nAward 227915/Z/23/Z (to D.J.O.,
J.A.G.B., and D.G.S.) and Wellcome PRF 207455/Z/17/Z (to\r\nD.J.O.); the Max Planck
Society (to J.A.G.B.); the Medical Research Council (UKRI) MC_\r\nUP_1201/16 (to
J.A.G.B.) and MRC DT P MR/N013433/1 (to J.G.G.K.); EMBO Long-term\r\nPostdoctoral
Fellowship ALT F-383-\r\n2022\r\n(to G.T.); and the Wellcome Trust/Royal Society,
Sir\r\nHenry Dale Fellowship 210481 (to D.C.G) and the Biotechnology and Biological
Sciences\r\nResearch Council (UKRI) responsive mode grants BB/W005905/1 and UKRI715
(to D.C.G.)."
article_number: eaed1529
article_processing_charge: Yes
article_type: original
author:
- first_name: Jonathan G.G.
full_name: Kaufman, Jonathan G.G.
last_name: Kaufman
- first_name: Grigory
full_name: Tagiltsev, Grigory
last_name: Tagiltsev
- first_name: Danièle S.
full_name: Stalder, Danièle S.
last_name: Stalder
- first_name: Rebecca J.
full_name: Taylor, Rebecca J.
last_name: Taylor
- first_name: Ioana
full_name: Sava, Ioana
last_name: Sava
- first_name: Hui
full_name: Guo, Hui
last_name: Guo
- first_name: Katarzyna A.
full_name: Ciazynska, Katarzyna A.
last_name: Ciazynska
- first_name: Nathan R.
full_name: Zaccai, Nathan R.
last_name: Zaccai
- first_name: Sally R.
full_name: Gray, Sally R.
last_name: Gray
- first_name: Yvonne
full_name: Vallis, Yvonne
id: 05A2795C-31B5-11EA-83A7-7DA23DDC885E
last_name: Vallis
orcid: 0000-0002-5408-5906
- first_name: Stefan
full_name: Höning, Stefan
last_name: Höning
- first_name: Bernard T.
full_name: Kelly, Bernard T.
last_name: Kelly
- first_name: David C.
full_name: Gershlick, David C.
last_name: Gershlick
- first_name: John A.G.
full_name: Briggs, John A.G.
last_name: Briggs
- first_name: David J.
full_name: Owen, David J.
last_name: Owen
citation:
ama: Kaufman JGG, Tagiltsev G, Stalder DS, et al. Architecture of clathrin-independent
AP3:ARF1-coated carriers. Science Advances. 2026;12(20). doi:10.1126/sciadv.aed1529
apa: Kaufman, J. G. G., Tagiltsev, G., Stalder, D. S., Taylor, R. J., Sava, I.,
Guo, H., … Owen, D. J. (2026). Architecture of clathrin-independent AP3:ARF1-coated
carriers. Science Advances. AAAS. https://doi.org/10.1126/sciadv.aed1529
chicago: Kaufman, Jonathan G.G., Grigory Tagiltsev, Danièle S. Stalder, Rebecca
J. Taylor, Ioana Sava, Hui Guo, Katarzyna A. Ciazynska, et al. “Architecture of
Clathrin-Independent AP3:ARF1-Coated Carriers.” Science Advances. AAAS,
2026. https://doi.org/10.1126/sciadv.aed1529.
ieee: J. G. G. Kaufman et al., “Architecture of clathrin-independent AP3:ARF1-coated
carriers,” Science Advances, vol. 12, no. 20. AAAS, 2026.
ista: Kaufman JGG, Tagiltsev G, Stalder DS, Taylor RJ, Sava I, Guo H, Ciazynska
KA, Zaccai NR, Gray SR, Vallis Y, Höning S, Kelly BT, Gershlick DC, Briggs JAG,
Owen DJ. 2026. Architecture of clathrin-independent AP3:ARF1-coated carriers.
Science Advances. 12(20), eaed1529.
mla: Kaufman, Jonathan G. G., et al. “Architecture of Clathrin-Independent AP3:ARF1-Coated
Carriers.” Science Advances, vol. 12, no. 20, eaed1529, AAAS, 2026, doi:10.1126/sciadv.aed1529.
short: J.G.G. Kaufman, G. Tagiltsev, D.S. Stalder, R.J. Taylor, I. Sava, H. Guo,
K.A. Ciazynska, N.R. Zaccai, S.R. Gray, Y. Vallis, S. Höning, B.T. Kelly, D.C.
Gershlick, J.A.G. Briggs, D.J. Owen, Science Advances 12 (2026).
das_tickbox: '1'
dataavailabilitystatement: "Structures determined by electron microscopy are deposited
in the Electron\r\nMicroscopy Data Bank under accession codes EMD-54255,\r\nEMD-54256,\r\nEMD-54257,\r\nand\r\nEMD-54258.\r\nCorresponding
molecular models are deposited in the Protein Data Bank under\r\naccession codes
9RTW, 9RTX, 9RTY, and 9RTZ. All additional data and code required to\r\nevaluate
and reproduce the results in the paper are present in the paper and/or the\r\nsupplementary
materials. Any code used is explicitly stated and available in the original\r\npublications.
Plasmids and cell lines can be requested by writing to D.C.G. (dg553@ cam. ac. uk)\r\nor
D.J.O. (djo30@ cam. ac. uk). All reasonable requests for materials will be honored."
date_created: 2026-07-13T10:52:15Z
date_published: 2026-05-15T00:00:00Z
date_updated: 2026-10-20T08:11:46Z
day: '15'
ddc:
- '570'
department:
- _id: MaDe
doi: 10.1126/sciadv.aed1529
file:
- access_level: open_access
checksum: 461b5f73941fe6b5df2a129c7563601f
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creator: dernst
date_created: 2026-07-14T06:45:37Z
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fulldoi: https://doi.org/10.1126/sciadv.aed1529
has_accepted_license: '1'
intvolume: ' 12'
issue: '20'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Architecture of clathrin-independent AP3:ARF1-coated carriers
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2026'
...