---
_id: '153'
abstract:
- lang: eng
  text: Cells migrating in multicellular organisms steadily traverse complex three-dimensional
    (3D) environments. To decipher the underlying cell biology, current experimental
    setups either use simplified 2D, tissue-mimetic 3D (e.g., collagen matrices) or
    in vivo environments. While only in vivo experiments are truly physiological,
    they do not allow for precise manipulation of environmental parameters. 2D in
    vitro experiments do allow mechanical and chemical manipulations, but increasing
    evidence demonstrates substantial differences of migratory mechanisms in 2D and
    3D. Here, we describe simple, robust, and versatile “pillar forests” to investigate
    cell migration in complex but fully controllable 3D environments. Pillar forests
    are polydimethylsiloxane-based setups, in which two closely adjacent surfaces
    are interconnected by arrays of micrometer-sized pillars. Changing the pillar
    shape, size, height and the inter-pillar distance precisely manipulates microenvironmental
    parameters (e.g., pore sizes, micro-geometry, micro-topology), while being easily
    combined with chemotactic cues, surface coatings, diverse cell types and advanced
    imaging techniques. Thus, pillar forests combine the advantages of 2D cell migration
    assays with the precise definition of 3D environmental parameters.
article_processing_charge: No
author:
- first_name: Jörg
  full_name: Renkawitz, Jörg
  id: 3F0587C8-F248-11E8-B48F-1D18A9856A87
  last_name: Renkawitz
  orcid: 0000-0003-2856-3369
- first_name: Anne
  full_name: Reversat, Anne
  id: 35B76592-F248-11E8-B48F-1D18A9856A87
  last_name: Reversat
  orcid: 0000-0003-0666-8928
- first_name: Alexander F
  full_name: Leithner, Alexander F
  id: 3B1B77E4-F248-11E8-B48F-1D18A9856A87
  last_name: Leithner
  orcid: 0000-0002-1073-744X
- first_name: Jack
  full_name: Merrin, Jack
  id: 4515C308-F248-11E8-B48F-1D18A9856A87
  last_name: Merrin
  orcid: 0000-0001-5145-4609
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
citation:
  ama: 'Renkawitz J, Reversat A, Leithner AF, Merrin J, Sixt MK. Micro-engineered
    “pillar forests” to study cell migration in complex but controlled 3D environments.
    In: <i>Methods in Cell Biology</i>. Vol 147. Academic Press; 2018:79-91. doi:<a
    href="https://doi.org/10.1016/bs.mcb.2018.07.004">10.1016/bs.mcb.2018.07.004</a>'
  apa: Renkawitz, J., Reversat, A., Leithner, A. F., Merrin, J., &#38; Sixt, M. K.
    (2018). Micro-engineered “pillar forests” to study cell migration in complex but
    controlled 3D environments. In <i>Methods in Cell Biology</i> (Vol. 147, pp. 79–91).
    Academic Press. <a href="https://doi.org/10.1016/bs.mcb.2018.07.004">https://doi.org/10.1016/bs.mcb.2018.07.004</a>
  chicago: Renkawitz, Jörg, Anne Reversat, Alexander F Leithner, Jack Merrin, and
    Michael K Sixt. “Micro-Engineered ‘Pillar Forests’ to Study Cell Migration in
    Complex but Controlled 3D Environments.” In <i>Methods in Cell Biology</i>, 147:79–91.
    Academic Press, 2018. <a href="https://doi.org/10.1016/bs.mcb.2018.07.004">https://doi.org/10.1016/bs.mcb.2018.07.004</a>.
  ieee: J. Renkawitz, A. Reversat, A. F. Leithner, J. Merrin, and M. K. Sixt, “Micro-engineered
    ‘pillar forests’ to study cell migration in complex but controlled 3D environments,”
    in <i>Methods in Cell Biology</i>, vol. 147, Academic Press, 2018, pp. 79–91.
  ista: 'Renkawitz J, Reversat A, Leithner AF, Merrin J, Sixt MK. 2018.Micro-engineered
    “pillar forests” to study cell migration in complex but controlled 3D environments.
    In: Methods in Cell Biology. vol. 147, 79–91.'
  mla: Renkawitz, Jörg, et al. “Micro-Engineered ‘Pillar Forests’ to Study Cell Migration
    in Complex but Controlled 3D Environments.” <i>Methods in Cell Biology</i>, vol.
    147, Academic Press, 2018, pp. 79–91, doi:<a href="https://doi.org/10.1016/bs.mcb.2018.07.004">10.1016/bs.mcb.2018.07.004</a>.
  short: J. Renkawitz, A. Reversat, A.F. Leithner, J. Merrin, M.K. Sixt, in:, Methods
    in Cell Biology, Academic Press, 2018, pp. 79–91.
date_created: 2018-12-11T11:44:54Z
date_published: 2018-07-27T00:00:00Z
date_updated: 2025-07-10T11:51:09Z
day: '27'
department:
- _id: MiSi
- _id: NanoFab
doi: 10.1016/bs.mcb.2018.07.004
external_id:
  isi:
  - '000452412300006'
  pmid:
  - '30165964'
fulldoi: https://doi.org/10.1016/bs.mcb.2018.07.004
intvolume: '       147'
isi: 1
language:
- iso: eng
month: '07'
oa_version: None
page: 79 - 91
pmid: 1
publication: Methods in Cell Biology
publication_identifier:
  issn:
  - 0091-679X
publication_status: published
publisher: Academic Press
publist_id: '7768'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Micro-engineered “pillar forests” to study cell migration in complex but controlled
  3D environments
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 147
year: '2018'
...
---
_id: '155'
abstract:
- lang: eng
  text: There is currently significant interest in operating devices in the quantum
    regime, where their behaviour cannot be explained through classical mechanics.
    Quantum states, including entangled states, are fragile and easily disturbed by
    excessive thermal noise. Here we address the question of whether it is possible
    to create non-reciprocal devices that encourage the flow of thermal noise towards
    or away from a particular quantum device in a network. Our work makes use of the
    cascaded systems formalism to answer this question in the affirmative, showing
    how a three-port device can be used as an effective thermal transistor, and illustrates
    how this formalism maps onto an experimentally-realisable optomechanical system.
    Our results pave the way to more resilient quantum devices and to the use of thermal
    noise as a resource.
alternative_title:
- Proceedings of SPIE
article_number: 106721N
article_processing_charge: No
arxiv: 1
author:
- first_name: André
  full_name: Xuereb, André
  last_name: Xuereb
- first_name: Matteo
  full_name: Aquilina, Matteo
  last_name: Aquilina
- first_name: Shabir
  full_name: Barzanjeh, Shabir
  id: 2D25E1F6-F248-11E8-B48F-1D18A9856A87
  last_name: Barzanjeh
  orcid: 0000-0003-0415-1423
citation:
  ama: 'Xuereb A, Aquilina M, Barzanjeh S. Routing thermal noise through quantum networks.
    In: Andrews DL, Ostendorf A, Bain AJ, Nunzi JM, eds. Vol 10672. SPIE; 2018. doi:<a
    href="https://doi.org/10.1117/12.2309928">10.1117/12.2309928</a>'
  apa: 'Xuereb, A., Aquilina, M., &#38; Barzanjeh, S. (2018). Routing thermal noise
    through quantum networks. In D. L. Andrews, A. Ostendorf, A. J. Bain, &#38; J.
    M. Nunzi (Eds.) (Vol. 10672). Presented at the SPIE: The international society
    for optical engineering, Strasbourg, France: SPIE. <a href="https://doi.org/10.1117/12.2309928">https://doi.org/10.1117/12.2309928</a>'
  chicago: Xuereb, André, Matteo Aquilina, and Shabir Barzanjeh. “Routing Thermal
    Noise through Quantum Networks.” edited by D L Andrews, A Ostendorf, A J Bain,
    and J M Nunzi, Vol. 10672. SPIE, 2018. <a href="https://doi.org/10.1117/12.2309928">https://doi.org/10.1117/12.2309928</a>.
  ieee: 'A. Xuereb, M. Aquilina, and S. Barzanjeh, “Routing thermal noise through
    quantum networks,” presented at the SPIE: The international society for optical
    engineering, Strasbourg, France, 2018, vol. 10672.'
  ista: 'Xuereb A, Aquilina M, Barzanjeh S. 2018. Routing thermal noise through quantum
    networks. SPIE: The international society for optical engineering, Proceedings
    of SPIE, vol. 10672, 106721N.'
  mla: Xuereb, André, et al. <i>Routing Thermal Noise through Quantum Networks</i>.
    Edited by D L Andrews et al., vol. 10672, 106721N, SPIE, 2018, doi:<a href="https://doi.org/10.1117/12.2309928">10.1117/12.2309928</a>.
  short: A. Xuereb, M. Aquilina, S. Barzanjeh, in:, D.L. Andrews, A. Ostendorf, A.J.
    Bain, J.M. Nunzi (Eds.), SPIE, 2018.
conference:
  end_date: 2018-04-26
  location: Strasbourg, France
  name: 'SPIE: The international society for optical engineering'
  start_date: 2018-04-22
date_created: 2018-12-11T11:44:55Z
date_published: 2018-05-04T00:00:00Z
date_updated: 2023-09-18T08:12:24Z
day: '04'
department:
- _id: JoFi
doi: 10.1117/12.2309928
editor:
- first_name: D L
  full_name: Andrews, D L
  last_name: Andrews
- first_name: A
  full_name: Ostendorf, A
  last_name: Ostendorf
- first_name: A J
  full_name: Bain, A J
  last_name: Bain
- first_name: J M
  full_name: Nunzi, J M
  last_name: Nunzi
external_id:
  arxiv:
  - '1806.01000'
  isi:
  - '000453298500019'
fulldoi: https://doi.org/10.1117/12.2309928
intvolume: '     10672'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1806.01000
month: '05'
oa: 1
oa_version: Preprint
publication_status: published
publisher: SPIE
publist_id: '7766'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Routing thermal noise through quantum networks
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 10672
year: '2018'
...
---
_id: '156'
abstract:
- lang: eng
  text: 'Imprecision in timing can sometimes be beneficial: Metric interval temporal
    logic (MITL), disabling the expression of punctuality constraints, was shown to
    translate to timed automata, yielding an elementary decision procedure. We show
    how this principle extends to other forms of dense-time specification using regular
    expressions. By providing a clean, automaton-based formal framework for non-punctual
    languages, we are able to recover and extend several results in timed systems.
    Metric interval regular expressions (MIRE) are introduced, providing regular expressions
    with non-singular duration constraints. We obtain that MIRE are expressively complete
    relative to a class of one-clock timed automata, which can be determinized using
    additional clocks. Metric interval dynamic logic (MIDL) is then defined using
    MIRE as temporal modalities. We show that MIDL generalizes known extensions of
    MITL, while translating to timed automata at comparable cost.'
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas
  full_name: Ferrere, Thomas
  id: 40960E6E-F248-11E8-B48F-1D18A9856A87
  last_name: Ferrere
  orcid: 0000-0001-5199-3143
citation:
  ama: 'Ferrere T. The compound interest in relaxing punctuality. In: Vol 10951. Springer;
    2018:147-164. doi:<a href="https://doi.org/10.1007/978-3-319-95582-7_9">10.1007/978-3-319-95582-7_9</a>'
  apa: 'Ferrere, T. (2018). The compound interest in relaxing punctuality (Vol. 10951,
    pp. 147–164). Presented at the FM: Formal Methods, Oxford, UK: Springer. <a href="https://doi.org/10.1007/978-3-319-95582-7_9">https://doi.org/10.1007/978-3-319-95582-7_9</a>'
  chicago: Ferrere, Thomas. “The Compound Interest in Relaxing Punctuality,” 10951:147–64.
    Springer, 2018. <a href="https://doi.org/10.1007/978-3-319-95582-7_9">https://doi.org/10.1007/978-3-319-95582-7_9</a>.
  ieee: 'T. Ferrere, “The compound interest in relaxing punctuality,” presented at
    the FM: Formal Methods, Oxford, UK, 2018, vol. 10951, pp. 147–164.'
  ista: 'Ferrere T. 2018. The compound interest in relaxing punctuality. FM: Formal
    Methods, LNCS, vol. 10951, 147–164.'
  mla: Ferrere, Thomas. <i>The Compound Interest in Relaxing Punctuality</i>. Vol.
    10951, Springer, 2018, pp. 147–64, doi:<a href="https://doi.org/10.1007/978-3-319-95582-7_9">10.1007/978-3-319-95582-7_9</a>.
  short: T. Ferrere, in:, Springer, 2018, pp. 147–164.
conference:
  end_date: 2018-07-17
  location: Oxford, UK
  name: 'FM: Formal Methods'
  start_date: 2018-07-15
date_created: 2018-12-11T11:44:55Z
date_published: 2018-07-12T00:00:00Z
date_updated: 2025-07-10T11:51:10Z
day: '12'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1007/978-3-319-95582-7_9
external_id:
  isi:
  - '000489765800009'
file:
- access_level: open_access
  checksum: a045c213c42c445f1889326f8db82a0a
  content_type: application/pdf
  creator: dernst
  date_created: 2020-10-09T06:22:41Z
  date_updated: 2020-10-09T06:22:41Z
  file_id: '8637'
  file_name: 2018_LNCS_Ferrere.pdf
  file_size: 485576
  relation: main_file
  success: 1
file_date_updated: 2020-10-09T06:22:41Z
fulldoi: https://doi.org/10.1007/978-3-319-95582-7_9
has_accepted_license: '1'
intvolume: '     10951'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Submitted Version
page: 147 - 164
project:
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z211
  name: Formal methods for the design and analysis of complex systems
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
publication_status: published
publisher: Springer
publist_id: '7765'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The compound interest in relaxing punctuality
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10951
year: '2018'
...
---
_id: '157'
abstract:
- lang: eng
  text: 'Social dilemmas occur when incentives for individuals are misaligned with
    group interests 1-7 . According to the ''tragedy of the commons'', these misalignments
    can lead to overexploitation and collapse of public resources. The resulting behaviours
    can be analysed with the tools of game theory 8 . The theory of direct reciprocity
    9-15 suggests that repeated interactions can alleviate such dilemmas, but previous
    work has assumed that the public resource remains constant over time. Here we
    introduce the idea that the public resource is instead changeable and depends
    on the strategic choices of individuals. An intuitive scenario is that cooperation
    increases the public resource, whereas defection decreases it. Thus, cooperation
    allows the possibility of playing a more valuable game with higher payoffs, whereas
    defection leads to a less valuable game. We analyse this idea using the theory
    of stochastic games 16-19 and evolutionary game theory. We find that the dependence
    of the public resource on previous interactions can greatly enhance the propensity
    for cooperation. For these results, the interaction between reciprocity and payoff
    feedback is crucial: neither repeated interactions in a constant environment nor
    single interactions in a changing environment yield similar cooperation rates.
    Our framework shows which feedbacks between exploitation and environment - either
    naturally occurring or designed - help to overcome social dilemmas.'
acknowledgement: "European Research Council Start Grant 279307, Austrian Science Fund
  (FWF) grant P23499-N23, \r\nC.H. acknowledges support from the ISTFELLOW programme."
article_processing_charge: No
author:
- first_name: Christian
  full_name: Hilbe, Christian
  id: 2FDF8F3C-F248-11E8-B48F-1D18A9856A87
  last_name: Hilbe
  orcid: 0000-0001-5116-955X
- first_name: Štepán
  full_name: Šimsa, Štepán
  last_name: Šimsa
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Martin
  full_name: Nowak, Martin
  last_name: Nowak
citation:
  ama: Hilbe C, Šimsa Š, Chatterjee K, Nowak M. Evolution of cooperation in stochastic
    games. <i>Nature</i>. 2018;559(7713):246-249. doi:<a href="https://doi.org/10.1038/s41586-018-0277-x">10.1038/s41586-018-0277-x</a>
  apa: Hilbe, C., Šimsa, Š., Chatterjee, K., &#38; Nowak, M. (2018). Evolution of
    cooperation in stochastic games. <i>Nature</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/s41586-018-0277-x">https://doi.org/10.1038/s41586-018-0277-x</a>
  chicago: Hilbe, Christian, Štepán Šimsa, Krishnendu Chatterjee, and Martin Nowak.
    “Evolution of Cooperation in Stochastic Games.” <i>Nature</i>. Nature Publishing
    Group, 2018. <a href="https://doi.org/10.1038/s41586-018-0277-x">https://doi.org/10.1038/s41586-018-0277-x</a>.
  ieee: C. Hilbe, Š. Šimsa, K. Chatterjee, and M. Nowak, “Evolution of cooperation
    in stochastic games,” <i>Nature</i>, vol. 559, no. 7713. Nature Publishing Group,
    pp. 246–249, 2018.
  ista: Hilbe C, Šimsa Š, Chatterjee K, Nowak M. 2018. Evolution of cooperation in
    stochastic games. Nature. 559(7713), 246–249.
  mla: Hilbe, Christian, et al. “Evolution of Cooperation in Stochastic Games.” <i>Nature</i>,
    vol. 559, no. 7713, Nature Publishing Group, 2018, pp. 246–49, doi:<a href="https://doi.org/10.1038/s41586-018-0277-x">10.1038/s41586-018-0277-x</a>.
  short: C. Hilbe, Š. Šimsa, K. Chatterjee, M. Nowak, Nature 559 (2018) 246–249.
date_created: 2018-12-11T11:44:56Z
date_published: 2018-07-04T00:00:00Z
date_updated: 2025-04-15T06:30:08Z
day: '04'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1038/s41586-018-0277-x
ec_funded: 1
external_id:
  isi:
  - '000438240900054'
file:
- access_level: open_access
  checksum: 011ab905cf9a410bc2b96f15174d654d
  content_type: application/pdf
  creator: dernst
  date_created: 2019-11-19T08:09:57Z
  date_updated: 2020-07-14T12:45:02Z
  file_id: '7049'
  file_name: 2018_Nature_Hilbe.pdf
  file_size: 2834442
  relation: main_file
file_date_updated: 2020-07-14T12:45:02Z
fulldoi: https://doi.org/10.1038/s41586-018-0277-x
has_accepted_license: '1'
intvolume: '       559'
isi: 1
issue: '7713'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Submitted Version
page: 246 - 249
project:
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S11407
  name: Game Theory
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2584A770-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P 23499-N23
  name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: Nature
publication_status: published
publisher: Nature Publishing Group
publist_id: '7764'
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/engineering-cooperation/
scopus_import: '1'
status: public
title: Evolution of cooperation in stochastic games
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 559
year: '2018'
...
---
_id: '158'
abstract:
- lang: eng
  text: 'The angiosperm seed is composed of three genetically distinct tissues: the
    diploid embryo that originates from the fertilized egg cell, the triploid endosperm
    that is produced from the fertilized central cell, and the maternal sporophytic
    integuments that develop into the seed coat1. At the onset of embryo development
    in Arabidopsis thaliana, the zygote divides asymmetrically, producing a small
    apical embryonic cell and a larger basal cell that connects the embryo to the
    maternal tissue2. The coordinated and synchronous development of the embryo and
    the surrounding integuments, and the alignment of their growth axes, suggest communication
    between maternal tissues and the embryo. In contrast to animals, however, where
    a network of maternal factors that direct embryo patterning have been identified3,4,
    only a few maternal mutations have been described to affect embryo development
    in plants5–7. Early embryo patterning in Arabidopsis requires accumulation of
    the phytohormone auxin in the apical cell by directed transport from the suspensor8–10.
    However, the origin of this auxin has remained obscure. Here we investigate the
    source of auxin for early embryogenesis and provide evidence that the mother plant
    coordinates seed development by supplying auxin to the early embryo from the integuments
    of the ovule. We show that auxin response increases in ovules after fertilization,
    due to upregulated auxin biosynthesis in the integuments, and this maternally
    produced auxin is required for correct embryo development.'
acknowledgement: This work was further supported by the Czech Science Foundation GACR
  (GA13-40637S) to J.F.;
article_processing_charge: No
author:
- first_name: Hélène
  full_name: Robert, Hélène
  last_name: Robert
- first_name: Chulmin
  full_name: Park, Chulmin
  last_name: Park
- first_name: Carla
  full_name: Gutièrrez, Carla
  last_name: Gutièrrez
- first_name: Barbara
  full_name: Wójcikowska, Barbara
  last_name: Wójcikowska
- first_name: Aleš
  full_name: Pěnčík, Aleš
  last_name: Pěnčík
- first_name: Ondřej
  full_name: Novák, Ondřej
  last_name: Novák
- first_name: Junyi
  full_name: Chen, Junyi
  last_name: Chen
- first_name: Wim
  full_name: Grunewald, Wim
  last_name: Grunewald
- first_name: Thomas
  full_name: Dresselhaus, Thomas
  last_name: Dresselhaus
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Thomas
  full_name: Laux, Thomas
  last_name: Laux
citation:
  ama: Robert H, Park C, Gutièrrez C, et al. Maternal auxin supply contributes to
    early embryo patterning in Arabidopsis. <i>Nature Plants</i>. 2018;4(8):548-553.
    doi:<a href="https://doi.org/10.1038/s41477-018-0204-z">10.1038/s41477-018-0204-z</a>
  apa: Robert, H., Park, C., Gutièrrez, C., Wójcikowska, B., Pěnčík, A., Novák, O.,
    … Laux, T. (2018). Maternal auxin supply contributes to early embryo patterning
    in Arabidopsis. <i>Nature Plants</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/s41477-018-0204-z">https://doi.org/10.1038/s41477-018-0204-z</a>
  chicago: Robert, Hélène, Chulmin Park, Carla Gutièrrez, Barbara Wójcikowska, Aleš
    Pěnčík, Ondřej Novák, Junyi Chen, et al. “Maternal Auxin Supply Contributes to
    Early Embryo Patterning in Arabidopsis.” <i>Nature Plants</i>. Nature Publishing
    Group, 2018. <a href="https://doi.org/10.1038/s41477-018-0204-z">https://doi.org/10.1038/s41477-018-0204-z</a>.
  ieee: H. Robert <i>et al.</i>, “Maternal auxin supply contributes to early embryo
    patterning in Arabidopsis,” <i>Nature Plants</i>, vol. 4, no. 8. Nature Publishing
    Group, pp. 548–553, 2018.
  ista: Robert H, Park C, Gutièrrez C, Wójcikowska B, Pěnčík A, Novák O, Chen J, Grunewald
    W, Dresselhaus T, Friml J, Laux T. 2018. Maternal auxin supply contributes to
    early embryo patterning in Arabidopsis. Nature Plants. 4(8), 548–553.
  mla: Robert, Hélène, et al. “Maternal Auxin Supply Contributes to Early Embryo Patterning
    in Arabidopsis.” <i>Nature Plants</i>, vol. 4, no. 8, Nature Publishing Group,
    2018, pp. 548–53, doi:<a href="https://doi.org/10.1038/s41477-018-0204-z">10.1038/s41477-018-0204-z</a>.
  short: H. Robert, C. Park, C. Gutièrrez, B. Wójcikowska, A. Pěnčík, O. Novák, J.
    Chen, W. Grunewald, T. Dresselhaus, J. Friml, T. Laux, Nature Plants 4 (2018)
    548–553.
date_created: 2018-12-11T11:44:56Z
date_published: 2018-07-16T00:00:00Z
date_updated: 2025-04-15T07:48:03Z
day: '16'
department:
- _id: JiFr
doi: 10.1038/s41477-018-0204-z
ec_funded: 1
external_id:
  isi:
  - '000443861300011'
  pmid:
  - '30013211'
fulldoi: https://doi.org/10.1038/s41477-018-0204-z
intvolume: '         4'
isi: 1
issue: '8'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pubmed/30013211
month: '07'
oa: 1
oa_version: Submitted Version
page: 548 - 553
pmid: 1
project:
- _id: 25716A02-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '282300'
  name: Polarity and subcellular dynamics in plants
publication: Nature Plants
publication_status: published
publisher: Nature Publishing Group
publist_id: '7763'
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/plant-mothers-talk-to-their-embryos-via-the-hormone-auxin/
scopus_import: '1'
status: public
title: Maternal auxin supply contributes to early embryo patterning in Arabidopsis
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 4
year: '2018'
...
---
_id: '159'
abstract:
- lang: eng
  text: L-type Ca2+ channels (LTCCs) play a crucial role in excitation-contraction
    coupling and release of hormones from secretory cells. They are targets of antihypertensive
    and antiarrhythmic drugs such as diltiazem. Here, we present a photoswitchable
    diltiazem, FHU-779, which can be used to reversibly block endogenous LTCCs by
    light. FHU-779 is as potent as diltiazem and can be used to place pancreatic β-cell
    function and cardiac activity under optical control.
article_processing_charge: No
article_type: original
author:
- first_name: Timm
  full_name: Fehrentz, Timm
  last_name: Fehrentz
- first_name: Florian
  full_name: Huber, Florian
  last_name: Huber
- first_name: Nina
  full_name: Hartrampf, Nina
  last_name: Hartrampf
- first_name: Tobias
  full_name: Bruegmann, Tobias
  last_name: Bruegmann
- first_name: James
  full_name: Frank, James
  last_name: Frank
- first_name: Nicholas
  full_name: Fine, Nicholas
  last_name: Fine
- first_name: Daniela
  full_name: Malan, Daniela
  last_name: Malan
- first_name: Johann G
  full_name: Danzl, Johann G
  id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
  last_name: Danzl
  orcid: 0000-0001-8559-3973
- first_name: Denis
  full_name: Tikhonov, Denis
  last_name: Tikhonov
- first_name: Maritn
  full_name: Sumser, Maritn
  last_name: Sumser
- first_name: Philipp
  full_name: Sasse, Philipp
  last_name: Sasse
- first_name: David
  full_name: Hodson, David
  last_name: Hodson
- first_name: Boris
  full_name: Zhorov, Boris
  last_name: Zhorov
- first_name: Nikolaj
  full_name: Klocker, Nikolaj
  last_name: Klocker
- first_name: Dirk
  full_name: Trauner, Dirk
  last_name: Trauner
citation:
  ama: Fehrentz T, Huber F, Hartrampf N, et al. Optical control of L-type Ca2+ channels
    using a diltiazem photoswitch. <i>Nature Chemical Biology</i>. 2018;14(8):764-767.
    doi:<a href="https://doi.org/10.1038/s41589-018-0090-8">10.1038/s41589-018-0090-8</a>
  apa: Fehrentz, T., Huber, F., Hartrampf, N., Bruegmann, T., Frank, J., Fine, N.,
    … Trauner, D. (2018). Optical control of L-type Ca2+ channels using a diltiazem
    photoswitch. <i>Nature Chemical Biology</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/s41589-018-0090-8">https://doi.org/10.1038/s41589-018-0090-8</a>
  chicago: Fehrentz, Timm, Florian Huber, Nina Hartrampf, Tobias Bruegmann, James
    Frank, Nicholas Fine, Daniela Malan, et al. “Optical Control of L-Type Ca2+ Channels
    Using a Diltiazem Photoswitch.” <i>Nature Chemical Biology</i>. Nature Publishing
    Group, 2018. <a href="https://doi.org/10.1038/s41589-018-0090-8">https://doi.org/10.1038/s41589-018-0090-8</a>.
  ieee: T. Fehrentz <i>et al.</i>, “Optical control of L-type Ca2+ channels using
    a diltiazem photoswitch,” <i>Nature Chemical Biology</i>, vol. 14, no. 8. Nature
    Publishing Group, pp. 764–767, 2018.
  ista: Fehrentz T, Huber F, Hartrampf N, Bruegmann T, Frank J, Fine N, Malan D, Danzl
    JG, Tikhonov D, Sumser M, Sasse P, Hodson D, Zhorov B, Klocker N, Trauner D. 2018.
    Optical control of L-type Ca2+ channels using a diltiazem photoswitch. Nature
    Chemical Biology. 14(8), 764–767.
  mla: Fehrentz, Timm, et al. “Optical Control of L-Type Ca2+ Channels Using a Diltiazem
    Photoswitch.” <i>Nature Chemical Biology</i>, vol. 14, no. 8, Nature Publishing
    Group, 2018, pp. 764–67, doi:<a href="https://doi.org/10.1038/s41589-018-0090-8">10.1038/s41589-018-0090-8</a>.
  short: T. Fehrentz, F. Huber, N. Hartrampf, T. Bruegmann, J. Frank, N. Fine, D.
    Malan, J.G. Danzl, D. Tikhonov, M. Sumser, P. Sasse, D. Hodson, B. Zhorov, N.
    Klocker, D. Trauner, Nature Chemical Biology 14 (2018) 764–767.
date_created: 2018-12-11T11:44:56Z
date_published: 2018-07-16T00:00:00Z
date_updated: 2023-09-13T09:36:35Z
day: '16'
ddc:
- '570'
department:
- _id: JoDa
doi: 10.1038/s41589-018-0090-8
external_id:
  isi:
  - '000438970200010'
file:
- access_level: open_access
  checksum: d42935094ec845f54a0688bf12986d62
  content_type: application/pdf
  creator: dernst
  date_created: 2020-05-14T12:14:09Z
  date_updated: 2020-07-14T12:45:03Z
  file_id: '7832'
  file_name: 2018_NatureChemicalBiology_Fehrentz.pdf
  file_size: 6321000
  relation: main_file
file_date_updated: 2020-07-14T12:45:03Z
fulldoi: https://doi.org/10.1038/s41589-018-0090-8
has_accepted_license: '1'
intvolume: '        14'
isi: 1
issue: '8'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Submitted Version
page: 764 - 767
publication: Nature Chemical Biology
publication_status: published
publisher: Nature Publishing Group
publist_id: '7762'
quality_controlled: '1'
related_material:
  link:
  - relation: erratum
    url: https://doi.org/10.1038/s41589-021-00744-3
scopus_import: '1'
status: public
title: Optical control of L-type Ca2+ channels using a diltiazem photoswitch
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 14
year: '2018'
...
---
_id: '16'
abstract:
- lang: eng
  text: We report quantitative evidence of mixing-layer elastic instability in a viscoelastic
    fluid flow between two widely spaced obstacles hindering a channel flow at Re
    1 and Wi 1. Two mixing layers with nonuniform shear velocity profiles are formed
    in the region between the obstacles. The mixing-layer instability arises in the
    vicinity of an inflection point on the shear velocity profile with a steep variation
    in the elastic stress. The instability results in an intermittent appearance of
    small vortices in the mixing layers and an amplification of spatiotemporal averaged
    vorticity in the elastic turbulence regime. The latter is characterized through
    scaling of friction factor with Wi and both pressure and velocity spectra. Furthermore,
    the observations reported provide improved understanding of the stability of the
    mixing layer in a viscoelastic fluid at large elasticity, i.e., Wi 1 and Re 1
    and oppose the current view of suppression of vorticity solely by polymer additives.
acknowledgement: This work was partially supported by the Israel Science Foundation
  (ISF; Grant No. 882/15) and the Binational USA-Israel Foundation (BSF; Grant No.
  2016145).
article_number: '103303'
article_processing_charge: No
article_type: original
author:
- first_name: Atul
  full_name: Varshney, Atul
  id: 2A2006B2-F248-11E8-B48F-1D18A9856A87
  last_name: Varshney
  orcid: 0000-0002-3072-5999
- first_name: Victor
  full_name: Steinberg, Victor
  last_name: Steinberg
citation:
  ama: Varshney A, Steinberg V. Mixing layer instability and vorticity amplification
    in a creeping viscoelastic flow. <i>Physical Review Fluids</i>. 2018;3(10). doi:<a
    href="https://doi.org/10.1103/PhysRevFluids.3.103303">10.1103/PhysRevFluids.3.103303</a>
  apa: Varshney, A., &#38; Steinberg, V. (2018). Mixing layer instability and vorticity
    amplification in a creeping viscoelastic flow. <i>Physical Review Fluids</i>.
    American Physical Society. <a href="https://doi.org/10.1103/PhysRevFluids.3.103303">https://doi.org/10.1103/PhysRevFluids.3.103303</a>
  chicago: Varshney, Atul, and Victor Steinberg. “Mixing Layer Instability and Vorticity
    Amplification in a Creeping Viscoelastic Flow.” <i>Physical Review Fluids</i>.
    American Physical Society, 2018. <a href="https://doi.org/10.1103/PhysRevFluids.3.103303">https://doi.org/10.1103/PhysRevFluids.3.103303</a>.
  ieee: A. Varshney and V. Steinberg, “Mixing layer instability and vorticity amplification
    in a creeping viscoelastic flow,” <i>Physical Review Fluids</i>, vol. 3, no. 10.
    American Physical Society, 2018.
  ista: Varshney A, Steinberg V. 2018. Mixing layer instability and vorticity amplification
    in a creeping viscoelastic flow. Physical Review Fluids. 3(10), 103303.
  mla: Varshney, Atul, and Victor Steinberg. “Mixing Layer Instability and Vorticity
    Amplification in a Creeping Viscoelastic Flow.” <i>Physical Review Fluids</i>,
    vol. 3, no. 10, 103303, American Physical Society, 2018, doi:<a href="https://doi.org/10.1103/PhysRevFluids.3.103303">10.1103/PhysRevFluids.3.103303</a>.
  short: A. Varshney, V. Steinberg, Physical Review Fluids 3 (2018).
date_created: 2018-12-11T11:44:10Z
date_published: 2018-10-16T00:00:00Z
date_updated: 2025-04-14T07:44:02Z
day: '16'
ddc:
- '532'
department:
- _id: BjHo
doi: 10.1103/PhysRevFluids.3.103303
ec_funded: 1
external_id:
  isi:
  - '000447469200001'
file:
- access_level: open_access
  checksum: 7fc0a2322214d1c04debef36d5bf2e8a
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:13:56Z
  date_updated: 2020-07-14T12:45:04Z
  file_id: '5043'
  file_name: IST-2018-1062-v1+1_PhysRevFluids.3.103303.pdf
  file_size: 1838431
  relation: main_file
file_date_updated: 2020-07-14T12:45:04Z
fulldoi: https://doi.org/10.1103/PhysRevFluids.3.103303
has_accepted_license: '1'
intvolume: '         3'
isi: 1
issue: '10'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Submitted Version
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: Physical Review Fluids
publication_status: published
publisher: American Physical Society
publist_id: '8039'
pubrep_id: '1062'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mixing layer instability and vorticity amplification in a creeping viscoelastic
  flow
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 3
year: '2018'
...
---
_id: '160'
abstract:
- lang: eng
  text: We present layered concurrent programs, a compact and expressive notation
    for specifying refinement proofs of concurrent programs. A layered concurrent
    program specifies a sequence of connected concurrent programs, from most concrete
    to most abstract, such that common parts of different programs are written exactly
    once. These programs are expressed in the ordinary syntax of imperative concurrent
    programs using gated atomic actions, sequencing, choice, and (recursive) procedure
    calls. Each concurrent program is automatically extracted from the layered program.
    We reduce refinement to the safety of a sequence of concurrent checker programs,
    one each to justify the connection between every two consecutive concurrent programs.
    These checker programs are also automatically extracted from the layered program.
    Layered concurrent programs have been implemented in the CIVL verifier which has
    been successfully used for the verification of several complex concurrent programs.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Bernhard
  full_name: Kragl, Bernhard
  id: 320FC952-F248-11E8-B48F-1D18A9856A87
  last_name: Kragl
  orcid: 0000-0001-7745-9117
- first_name: Shaz
  full_name: Qadeer, Shaz
  last_name: Qadeer
citation:
  ama: 'Kragl B, Qadeer S. Layered Concurrent Programs. In: Vol 10981. Springer; 2018:79-102.
    doi:<a href="https://doi.org/10.1007/978-3-319-96145-3_5">10.1007/978-3-319-96145-3_5</a>'
  apa: 'Kragl, B., &#38; Qadeer, S. (2018). Layered Concurrent Programs (Vol. 10981,
    pp. 79–102). Presented at the CAV: Computer Aided Verification, Oxford, UK: Springer.
    <a href="https://doi.org/10.1007/978-3-319-96145-3_5">https://doi.org/10.1007/978-3-319-96145-3_5</a>'
  chicago: Kragl, Bernhard, and Shaz Qadeer. “Layered Concurrent Programs,” 10981:79–102.
    Springer, 2018. <a href="https://doi.org/10.1007/978-3-319-96145-3_5">https://doi.org/10.1007/978-3-319-96145-3_5</a>.
  ieee: 'B. Kragl and S. Qadeer, “Layered Concurrent Programs,” presented at the CAV:
    Computer Aided Verification, Oxford, UK, 2018, vol. 10981, pp. 79–102.'
  ista: 'Kragl B, Qadeer S. 2018. Layered Concurrent Programs. CAV: Computer Aided
    Verification, LNCS, vol. 10981, 79–102.'
  mla: Kragl, Bernhard, and Shaz Qadeer. <i>Layered Concurrent Programs</i>. Vol.
    10981, Springer, 2018, pp. 79–102, doi:<a href="https://doi.org/10.1007/978-3-319-96145-3_5">10.1007/978-3-319-96145-3_5</a>.
  short: B. Kragl, S. Qadeer, in:, Springer, 2018, pp. 79–102.
conference:
  end_date: 2018-07-17
  location: Oxford, UK
  name: 'CAV: Computer Aided Verification'
  start_date: 2018-07-14
date_created: 2018-12-11T11:44:57Z
date_published: 2018-07-18T00:00:00Z
date_updated: 2026-04-08T07:23:52Z
day: '18'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1007/978-3-319-96145-3_5
external_id:
  isi:
  - '000491481600005'
file:
- access_level: open_access
  checksum: c64fff560fe5a7532ec10626ad1c215e
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  creator: dernst
  date_created: 2018-12-17T12:52:12Z
  date_updated: 2020-07-14T12:45:04Z
  file_id: '5705'
  file_name: 2018_LNCS_Kragl.pdf
  file_size: 1603844
  relation: main_file
file_date_updated: 2020-07-14T12:45:04Z
fulldoi: https://doi.org/10.1007/978-3-319-96145-3_5
has_accepted_license: '1'
intvolume: '     10981'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 79 - 102
project:
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z211
  name: Formal methods for the design and analysis of complex systems
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
publication_status: published
publisher: Springer
publist_id: '7761'
quality_controlled: '1'
related_material:
  record:
  - id: '8332'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Layered Concurrent Programs
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 10981
year: '2018'
...
---
_id: '161'
abstract:
- lang: eng
  text: 'Which properties of metabolic networks can be derived solely from stoichiometry?
    Predictive results have been obtained by flux balance analysis (FBA), by postulating
    that cells set metabolic fluxes to maximize growth rate. Here we consider a generalization
    of FBA to single-cell level using maximum entropy modeling, which we extend and
    test experimentally. Specifically, we define for Escherichia coli metabolism a
    flux distribution that yields the experimental growth rate: the model, containing
    FBA as a limit, provides a better match to measured fluxes and it makes a wide
    range of predictions: on flux variability, regulation, and correlations; on the
    relative importance of stoichiometry vs. optimization; on scaling relations for
    growth rate distributions. We validate the latter here with single-cell data at
    different sub-inhibitory antibiotic concentrations. The model quantifies growth
    optimization as emerging from the interplay of competitive dynamics in the population
    and regulation of metabolism at the level of single cells.'
article_number: '2988'
article_processing_charge: No
author:
- first_name: Daniele
  full_name: De Martino, Daniele
  id: 3FF5848A-F248-11E8-B48F-1D18A9856A87
  last_name: De Martino
  orcid: 0000-0002-5214-4706
- first_name: Andersson Anna
  full_name: Mc, Andersson Anna
  last_name: Mc
- first_name: Tobias
  full_name: Bergmiller, Tobias
  id: 2C471CFA-F248-11E8-B48F-1D18A9856A87
  last_name: Bergmiller
  orcid: 0000-0001-5396-4346
- first_name: Calin C
  full_name: Guet, Calin C
  id: 47F8433E-F248-11E8-B48F-1D18A9856A87
  last_name: Guet
  orcid: 0000-0001-6220-2052
- first_name: Gasper
  full_name: Tkacik, Gasper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkacik
  orcid: 0000-0002-6699-1455
citation:
  ama: De Martino D, Mc AA, Bergmiller T, Guet CC, Tkačik G. Statistical mechanics
    for metabolic networks during steady state growth. <i>Nature Communications</i>.
    2018;9(1). doi:<a href="https://doi.org/10.1038/s41467-018-05417-9">10.1038/s41467-018-05417-9</a>
  apa: De Martino, D., Mc, A. A., Bergmiller, T., Guet, C. C., &#38; Tkačik, G. (2018).
    Statistical mechanics for metabolic networks during steady state growth. <i>Nature
    Communications</i>. Springer Nature. <a href="https://doi.org/10.1038/s41467-018-05417-9">https://doi.org/10.1038/s41467-018-05417-9</a>
  chicago: De Martino, Daniele, Andersson Anna Mc, Tobias Bergmiller, Calin C Guet,
    and Gašper Tkačik. “Statistical Mechanics for Metabolic Networks during Steady
    State Growth.” <i>Nature Communications</i>. Springer Nature, 2018. <a href="https://doi.org/10.1038/s41467-018-05417-9">https://doi.org/10.1038/s41467-018-05417-9</a>.
  ieee: D. De Martino, A. A. Mc, T. Bergmiller, C. C. Guet, and G. Tkačik, “Statistical
    mechanics for metabolic networks during steady state growth,” <i>Nature Communications</i>,
    vol. 9, no. 1. Springer Nature, 2018.
  ista: De Martino D, Mc AA, Bergmiller T, Guet CC, Tkačik G. 2018. Statistical mechanics
    for metabolic networks during steady state growth. Nature Communications. 9(1),
    2988.
  mla: De Martino, Daniele, et al. “Statistical Mechanics for Metabolic Networks during
    Steady State Growth.” <i>Nature Communications</i>, vol. 9, no. 1, 2988, Springer
    Nature, 2018, doi:<a href="https://doi.org/10.1038/s41467-018-05417-9">10.1038/s41467-018-05417-9</a>.
  short: D. De Martino, A.A. Mc, T. Bergmiller, C.C. Guet, G. Tkačik, Nature Communications
    9 (2018).
date_created: 2018-12-11T11:44:57Z
date_published: 2018-07-30T00:00:00Z
date_updated: 2025-04-15T06:50:08Z
day: '30'
ddc:
- '570'
department:
- _id: GaTk
- _id: CaGu
doi: 10.1038/s41467-018-05417-9
ec_funded: 1
external_id:
  isi:
  - '000440149300021'
file:
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  checksum: 3ba7ab27b27723c7dcf633e8fc1f8f18
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T16:44:28Z
  date_updated: 2020-07-14T12:45:06Z
  file_id: '5728'
  file_name: 2018_NatureComm_DeMartino.pdf
  file_size: 1043205
  relation: main_file
file_date_updated: 2020-07-14T12:45:06Z
fulldoi: https://doi.org/10.1038/s41467-018-05417-9
has_accepted_license: '1'
intvolume: '         9'
isi: 1
issue: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 254E9036-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P28844-B27
  name: Biophysics of information processing in gene regulation
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: Nature Communications
publication_status: published
publisher: Springer Nature
publist_id: '7760'
quality_controlled: '1'
related_material:
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  - id: '5587'
    relation: popular_science
    status: public
scopus_import: '1'
status: public
title: Statistical mechanics for metabolic networks during steady state growth
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 9
year: '2018'
...
---
_id: '162'
abstract:
- lang: eng
  text: 'Facial shape is the basis for facial recognition and categorization. Facial
    features reflect the underlying geometry of the skeletal structures. Here, we
    reveal that cartilaginous nasal capsule (corresponding to upper jaw and face)
    is shaped by signals generated by neural structures: brain and olfactory epithelium.
    Brain-derived Sonic Hedgehog (SHH) enables the induction of nasal septum and posterior
    nasal capsule, whereas the formation of a capsule roof is controlled by signals
    from the olfactory epithelium. Unexpectedly, the cartilage of the nasal capsule
    turned out to be important for shaping membranous facial bones during development.
    This suggests that conserved neurosensory structures could benefit from protection
    and have evolved signals inducing cranial cartilages encasing them. Experiments
    with mutant mice revealed that the genomic regulatory regions controlling production
    of SHH in the nervous system contribute to facial cartilage morphogenesis, which
    might be a mechanism responsible for the adaptive evolution of animal faces and
    snouts.'
article_number: e34465
article_processing_charge: No
author:
- first_name: Marketa
  full_name: Kaucka, Marketa
  last_name: Kaucka
- first_name: Julian
  full_name: Petersen, Julian
  last_name: Petersen
- first_name: Marketa
  full_name: Tesarova, Marketa
  last_name: Tesarova
- first_name: Bara
  full_name: Szarowska, Bara
  last_name: Szarowska
- first_name: Maria
  full_name: Kastriti, Maria
  last_name: Kastriti
- first_name: Meng
  full_name: Xie, Meng
  last_name: Xie
- first_name: Anna
  full_name: Kicheva, Anna
  id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
  last_name: Kicheva
  orcid: 0000-0003-4509-4998
- first_name: Karl
  full_name: Annusver, Karl
  last_name: Annusver
- first_name: Maria
  full_name: Kasper, Maria
  last_name: Kasper
- first_name: Orsolya
  full_name: Symmons, Orsolya
  last_name: Symmons
- first_name: Leslie
  full_name: Pan, Leslie
  last_name: Pan
- first_name: Francois
  full_name: Spitz, Francois
  last_name: Spitz
- first_name: Jozef
  full_name: Kaiser, Jozef
  last_name: Kaiser
- first_name: Maria
  full_name: Hovorakova, Maria
  last_name: Hovorakova
- first_name: Tomas
  full_name: Zikmund, Tomas
  last_name: Zikmund
- first_name: Kazunori
  full_name: Sunadome, Kazunori
  last_name: Sunadome
- first_name: Michael P
  full_name: Matise, Michael P
  last_name: Matise
- first_name: Hui
  full_name: Wang, Hui
  last_name: Wang
- first_name: Ulrika
  full_name: Marklund, Ulrika
  last_name: Marklund
- first_name: Hind
  full_name: Abdo, Hind
  last_name: Abdo
- first_name: Patrik
  full_name: Ernfors, Patrik
  last_name: Ernfors
- first_name: Pascal
  full_name: Maire, Pascal
  last_name: Maire
- first_name: Maud
  full_name: Wurmser, Maud
  last_name: Wurmser
- first_name: Andrei S
  full_name: Chagin, Andrei S
  last_name: Chagin
- first_name: Kaj
  full_name: Fried, Kaj
  last_name: Fried
- first_name: Igor
  full_name: Adameyko, Igor
  last_name: Adameyko
citation:
  ama: Kaucka M, Petersen J, Tesarova M, et al. Signals from the brain and olfactory
    epithelium control shaping of the mammalian nasal capsule cartilage. <i>eLife</i>.
    2018;7. doi:<a href="https://doi.org/10.7554/eLife.34465">10.7554/eLife.34465</a>
  apa: Kaucka, M., Petersen, J., Tesarova, M., Szarowska, B., Kastriti, M., Xie, M.,
    … Adameyko, I. (2018). Signals from the brain and olfactory epithelium control
    shaping of the mammalian nasal capsule cartilage. <i>ELife</i>. eLife Sciences
    Publications. <a href="https://doi.org/10.7554/eLife.34465">https://doi.org/10.7554/eLife.34465</a>
  chicago: Kaucka, Marketa, Julian Petersen, Marketa Tesarova, Bara Szarowska, Maria
    Kastriti, Meng Xie, Anna Kicheva, et al. “Signals from the Brain and Olfactory
    Epithelium Control Shaping of the Mammalian Nasal Capsule Cartilage.” <i>ELife</i>.
    eLife Sciences Publications, 2018. <a href="https://doi.org/10.7554/eLife.34465">https://doi.org/10.7554/eLife.34465</a>.
  ieee: M. Kaucka <i>et al.</i>, “Signals from the brain and olfactory epithelium
    control shaping of the mammalian nasal capsule cartilage,” <i>eLife</i>, vol.
    7. eLife Sciences Publications, 2018.
  ista: Kaucka M, Petersen J, Tesarova M, Szarowska B, Kastriti M, Xie M, Kicheva
    A, Annusver K, Kasper M, Symmons O, Pan L, Spitz F, Kaiser J, Hovorakova M, Zikmund
    T, Sunadome K, Matise MP, Wang H, Marklund U, Abdo H, Ernfors P, Maire P, Wurmser
    M, Chagin AS, Fried K, Adameyko I. 2018. Signals from the brain and olfactory
    epithelium control shaping of the mammalian nasal capsule cartilage. eLife. 7,
    e34465.
  mla: Kaucka, Marketa, et al. “Signals from the Brain and Olfactory Epithelium Control
    Shaping of the Mammalian Nasal Capsule Cartilage.” <i>ELife</i>, vol. 7, e34465,
    eLife Sciences Publications, 2018, doi:<a href="https://doi.org/10.7554/eLife.34465">10.7554/eLife.34465</a>.
  short: M. Kaucka, J. Petersen, M. Tesarova, B. Szarowska, M. Kastriti, M. Xie, A.
    Kicheva, K. Annusver, M. Kasper, O. Symmons, L. Pan, F. Spitz, J. Kaiser, M. Hovorakova,
    T. Zikmund, K. Sunadome, M.P. Matise, H. Wang, U. Marklund, H. Abdo, P. Ernfors,
    P. Maire, M. Wurmser, A.S. Chagin, K. Fried, I. Adameyko, ELife 7 (2018).
date_created: 2018-12-11T11:44:57Z
date_published: 2018-06-13T00:00:00Z
date_updated: 2025-04-14T07:27:30Z
day: '13'
ddc:
- '571'
department:
- _id: AnKi
doi: 10.7554/eLife.34465
ec_funded: 1
external_id:
  isi:
  - '000436227500001'
file:
- access_level: open_access
  checksum: da2378cdcf6b5461dcde194e4d608343
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T16:41:58Z
  date_updated: 2020-07-14T12:45:07Z
  file_id: '5727'
  file_name: 2018_eLife_Kaucka.pdf
  file_size: 9816484
  relation: main_file
file_date_updated: 2020-07-14T12:45:07Z
fulldoi: https://doi.org/10.7554/eLife.34465
has_accepted_license: '1'
intvolume: '         7'
isi: 1
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
  call_identifier: H2020
  grant_number: '680037'
  name: Coordination of Patterning And Growth In the Spinal Cord
publication: eLife
publication_status: published
publisher: eLife Sciences Publications
publist_id: '7759'
quality_controlled: '1'
related_material:
  record:
  - id: '9838'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Signals from the brain and olfactory epithelium control shaping of the mammalian
  nasal capsule cartilage
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 7
year: '2018'
...
---
_id: '163'
abstract:
- lang: eng
  text: For ultrafast fixation of biological samples to avoid artifacts, high-pressure
    freezing (HPF) followed by freeze substitution (FS) is preferred over chemical
    fixation at room temperature. After HPF, samples are maintained at low temperature
    during dehydration and fixation, while avoiding damaging recrystallization. This
    is a notoriously slow process. McDonald and Webb demonstrated, in 2011, that sample
    agitation during FS dramatically reduces the necessary time. Then, in 2015, we
    (H.G. and S.R.) introduced an agitation module into the cryochamber of an automated
    FS unit and demonstrated that the preparation of algae could be shortened from
    days to a couple of hours. We argued that variability in the processing, reproducibility,
    and safety issues are better addressed using automated FS units. For dissemination,
    we started low-cost manufacturing of agitation modules for two of the most widely
    used FS units, the Automatic Freeze Substitution Systems, AFS(1) and AFS2, from
    Leica Microsystems, using three dimensional (3D)-printing of the major components.
    To test them, several labs independently used the modules on a wide variety of
    specimens that had previously been processed by manual agitation, or without agitation.
    We demonstrate that automated processing with sample agitation saves time, increases
    flexibility with respect to sample requirements and protocols, and produces data
    of at least as good quality as other approaches.
article_processing_charge: No
article_type: original
author:
- first_name: Siegfried
  full_name: Reipert, Siegfried
  last_name: Reipert
- first_name: Helmuth
  full_name: Goldammer, Helmuth
  last_name: Goldammer
- first_name: Christine
  full_name: Richardson, Christine
  last_name: Richardson
- first_name: Martin
  full_name: Goldberg, Martin
  last_name: Goldberg
- first_name: Timothy
  full_name: Hawkins, Timothy
  last_name: Hawkins
- first_name: Elena
  full_name: Hollergschwandtner, Elena
  id: 3C054040-F248-11E8-B48F-1D18A9856A87
  last_name: Hollergschwandtner
- first_name: Walter
  full_name: Kaufmann, Walter
  id: 3F99E422-F248-11E8-B48F-1D18A9856A87
  last_name: Kaufmann
  orcid: 0000-0001-9735-5315
- first_name: Sebastian
  full_name: Antreich, Sebastian
  last_name: Antreich
- first_name: York
  full_name: Stierhof, York
  last_name: Stierhof
citation:
  ama: 'Reipert S, Goldammer H, Richardson C, et al. Agitation modules: Flexible means
    to accelerate automated freeze substitution. <i>Journal of Histochemistry and
    Cytochemistry</i>. 2018;66(12):903-921. doi:<a href="https://doi.org/10.1369/0022155418786698">10.1369/0022155418786698</a>'
  apa: 'Reipert, S., Goldammer, H., Richardson, C., Goldberg, M., Hawkins, T., Saeckl,
    E., … Stierhof, Y. (2018). Agitation modules: Flexible means to accelerate automated
    freeze substitution. <i>Journal of Histochemistry and Cytochemistry</i>. SAGE
    Publications. <a href="https://doi.org/10.1369/0022155418786698">https://doi.org/10.1369/0022155418786698</a>'
  chicago: 'Reipert, Siegfried, Helmuth Goldammer, Christine Richardson, Martin Goldberg,
    Timothy Hawkins, Elena Saeckl, Walter Kaufmann, Sebastian Antreich, and York Stierhof.
    “Agitation Modules: Flexible Means to Accelerate Automated Freeze Substitution.”
    <i>Journal of Histochemistry and Cytochemistry</i>. SAGE Publications, 2018. <a
    href="https://doi.org/10.1369/0022155418786698">https://doi.org/10.1369/0022155418786698</a>.'
  ieee: 'S. Reipert <i>et al.</i>, “Agitation modules: Flexible means to accelerate
    automated freeze substitution,” <i>Journal of Histochemistry and Cytochemistry</i>,
    vol. 66, no. 12. SAGE Publications, pp. 903–921, 2018.'
  ista: 'Reipert S, Goldammer H, Richardson C, Goldberg M, Hawkins T, Saeckl E, Kaufmann
    W, Antreich S, Stierhof Y. 2018. Agitation modules: Flexible means to accelerate
    automated freeze substitution. Journal of Histochemistry and Cytochemistry. 66(12),
    903–921.'
  mla: 'Reipert, Siegfried, et al. “Agitation Modules: Flexible Means to Accelerate
    Automated Freeze Substitution.” <i>Journal of Histochemistry and Cytochemistry</i>,
    vol. 66, no. 12, SAGE Publications, 2018, pp. 903–21, doi:<a href="https://doi.org/10.1369/0022155418786698">10.1369/0022155418786698</a>.'
  short: S. Reipert, H. Goldammer, C. Richardson, M. Goldberg, T. Hawkins, E. Saeckl,
    W. Kaufmann, S. Antreich, Y. Stierhof, Journal of Histochemistry and Cytochemistry
    66 (2018) 903–921.
date_created: 2018-12-11T11:44:57Z
date_published: 2018-12-01T00:00:00Z
date_updated: 2026-06-18T17:50:00Z
day: '01'
ddc:
- '570'
department:
- _id: RySh
- _id: EM-Fac
doi: 10.1369/0022155418786698
external_id:
  isi:
  - '000452277700005'
  pmid:
  - '29969056'
fulldoi: https://doi.org/10.1369/0022155418786698
intvolume: '        66'
isi: 1
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1369/0022155418786698
month: '12'
oa: 1
oa_version: Published Version
page: 903-921
pmid: 1
publication: Journal of Histochemistry and Cytochemistry
publication_identifier:
  issn:
  - 0022-1554
publication_status: published
publisher: SAGE Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Agitation modules: Flexible means to accelerate automated freeze substitution'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 66
year: '2018'
...
---
_id: '17'
abstract:
- lang: eng
  text: Creeping flow of polymeric fluid without inertia exhibits elastic instabilities
    and elastic turbulence accompanied by drag enhancement due to elastic stress produced
    by flow-stretched polymers. However, in inertia-dominated flow at high Re and
    low fluid elasticity El, a reduction in turbulent frictional drag is caused by
    an intricate competition between inertial and elastic stresses. Here we explore
    the effect of inertia on the stability of viscoelastic flow in a broad range of
    control parameters El and (Re,Wi). We present the stability diagram of observed
    flow regimes in Wi-Re coordinates and find that the instabilities' onsets show
    an unexpectedly nonmonotonic dependence on El. Further, three distinct regions
    in the diagram are identified based on El. Strikingly, for high-elasticity fluids
    we discover a complete relaminarization of flow at Reynolds number in the range
    of 1 to 10, different from a well-known turbulent drag reduction. These counterintuitive
    effects may be explained by a finite polymer extensibility and a suppression of
    vorticity at high Wi. Our results call for further theoretical and numerical development
    to uncover the role of inertial effect on elastic turbulence in a viscoelastic
    flow.
article_number: '103302 '
article_processing_charge: No
author:
- first_name: Atul
  full_name: Varshney, Atul
  id: 2A2006B2-F248-11E8-B48F-1D18A9856A87
  last_name: Varshney
  orcid: 0000-0002-3072-5999
- first_name: Victor
  full_name: Steinberg, Victor
  last_name: Steinberg
citation:
  ama: Varshney A, Steinberg V. Drag enhancement and drag reduction in viscoelastic
    flow. <i>Physical Review Fluids</i>. 2018;3(10). doi:<a href="https://doi.org/10.1103/PhysRevFluids.3.103302">10.1103/PhysRevFluids.3.103302</a>
  apa: Varshney, A., &#38; Steinberg, V. (2018). Drag enhancement and drag reduction
    in viscoelastic flow. <i>Physical Review Fluids</i>. American Physical Society.
    <a href="https://doi.org/10.1103/PhysRevFluids.3.103302">https://doi.org/10.1103/PhysRevFluids.3.103302</a>
  chicago: Varshney, Atul, and Victor Steinberg. “Drag Enhancement and Drag Reduction
    in Viscoelastic Flow.” <i>Physical Review Fluids</i>. American Physical Society,
    2018. <a href="https://doi.org/10.1103/PhysRevFluids.3.103302">https://doi.org/10.1103/PhysRevFluids.3.103302</a>.
  ieee: A. Varshney and V. Steinberg, “Drag enhancement and drag reduction in viscoelastic
    flow,” <i>Physical Review Fluids</i>, vol. 3, no. 10. American Physical Society,
    2018.
  ista: Varshney A, Steinberg V. 2018. Drag enhancement and drag reduction in viscoelastic
    flow. Physical Review Fluids. 3(10), 103302.
  mla: Varshney, Atul, and Victor Steinberg. “Drag Enhancement and Drag Reduction
    in Viscoelastic Flow.” <i>Physical Review Fluids</i>, vol. 3, no. 10, 103302,
    American Physical Society, 2018, doi:<a href="https://doi.org/10.1103/PhysRevFluids.3.103302">10.1103/PhysRevFluids.3.103302</a>.
  short: A. Varshney, V. Steinberg, Physical Review Fluids 3 (2018).
date_created: 2018-12-11T11:44:11Z
date_published: 2018-10-15T00:00:00Z
date_updated: 2025-04-14T07:43:59Z
day: '15'
ddc:
- '532'
department:
- _id: BjHo
doi: 10.1103/PhysRevFluids.3.103302
ec_funded: 1
external_id:
  isi:
  - '000447311500001'
file:
- access_level: open_access
  checksum: e1445be33e8165114e96246275600750
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:10:14Z
  date_updated: 2020-07-14T12:45:12Z
  file_id: '4800'
  file_name: IST-2018-1061-v1+1_PhysRevFluids.3.103302.pdf
  file_size: 1409040
  relation: main_file
file_date_updated: 2020-07-14T12:45:12Z
fulldoi: https://doi.org/10.1103/PhysRevFluids.3.103302
has_accepted_license: '1'
intvolume: '         3'
isi: 1
issue: '10'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: Physical Review Fluids
publication_status: published
publisher: American Physical Society
publist_id: '8038'
pubrep_id: '1061'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Drag enhancement and drag reduction in viscoelastic flow
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 3
year: '2018'
...
---
_id: '185'
abstract:
- lang: eng
  text: We resolve in the affirmative conjectures of A. Skopenkov and Repovš (1998),
    and M. Skopenkov (2003) generalizing the classical Hanani-Tutte theorem to the
    setting of approximating maps of graphs on 2-dimensional surfaces by embeddings.
    Our proof of this result is constructive and almost immediately implies an efficient
    algorithm for testing whether a given piecewise linear map of a graph in a surface
    is approximable by an embedding. More precisely, an instance of this problem consists
    of (i) a graph G whose vertices are partitioned into clusters and whose inter-cluster
    edges are partitioned into bundles, and (ii) a region R of a 2-dimensional compact
    surface M given as the union of a set of pairwise disjoint discs corresponding
    to the clusters and a set of pairwise disjoint &quot;pipes&quot; corresponding
    to the bundles, connecting certain pairs of these discs. We are to decide whether
    G can be embedded inside M so that the vertices in every cluster are drawn in
    the corresponding disc, the edges in every bundle pass only through its corresponding
    pipe, and every edge crosses the boundary of each disc at most once.
alternative_title:
- Leibniz International Proceedings in Information, LIPIcs
article_number: '39'
author:
- first_name: Radoslav
  full_name: Fulek, Radoslav
  id: 39F3FFE4-F248-11E8-B48F-1D18A9856A87
  last_name: Fulek
  orcid: 0000-0001-8485-1774
- first_name: Jan
  full_name: Kynčl, Jan
  last_name: Kynčl
citation:
  ama: 'Fulek R, Kynčl J. Hanani-Tutte for approximating maps of graphs. In: Vol 99.
    Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2018. doi:<a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.39">10.4230/LIPIcs.SoCG.2018.39</a>'
  apa: 'Fulek, R., &#38; Kynčl, J. (2018). Hanani-Tutte for approximating maps of
    graphs (Vol. 99). Presented at the SoCG: Symposium on Computational Geometry,
    Budapest, Hungary: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.39">https://doi.org/10.4230/LIPIcs.SoCG.2018.39</a>'
  chicago: Fulek, Radoslav, and Jan Kynčl. “Hanani-Tutte for Approximating Maps of
    Graphs,” Vol. 99. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2018. <a
    href="https://doi.org/10.4230/LIPIcs.SoCG.2018.39">https://doi.org/10.4230/LIPIcs.SoCG.2018.39</a>.
  ieee: 'R. Fulek and J. Kynčl, “Hanani-Tutte for approximating maps of graphs,” presented
    at the SoCG: Symposium on Computational Geometry, Budapest, Hungary, 2018, vol.
    99.'
  ista: 'Fulek R, Kynčl J. 2018. Hanani-Tutte for approximating maps of graphs. SoCG:
    Symposium on Computational Geometry, Leibniz International Proceedings in Information,
    LIPIcs, vol. 99, 39.'
  mla: Fulek, Radoslav, and Jan Kynčl. <i>Hanani-Tutte for Approximating Maps of Graphs</i>.
    Vol. 99, 39, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2018, doi:<a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.39">10.4230/LIPIcs.SoCG.2018.39</a>.
  short: R. Fulek, J. Kynčl, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2018.
conference:
  end_date: 2018-06-14
  location: Budapest, Hungary
  name: 'SoCG: Symposium on Computational Geometry'
  start_date: 2018-06-11
date_created: 2018-12-11T11:45:04Z
date_published: 2018-01-01T00:00:00Z
date_updated: 2021-01-12T06:53:36Z
day: '01'
ddc:
- '510'
department:
- _id: UlWa
doi: 10.4230/LIPIcs.SoCG.2018.39
file:
- access_level: open_access
  checksum: f1b94f1a75b37c414a1f61d59fb2cd4c
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T12:33:52Z
  date_updated: 2020-07-14T12:45:19Z
  file_id: '5701'
  file_name: 2018_LIPIcs_Fulek.pdf
  file_size: 718857
  relation: main_file
file_date_updated: 2020-07-14T12:45:19Z
fulldoi: https://doi.org/10.4230/LIPIcs.SoCG.2018.39
has_accepted_license: '1'
intvolume: '        99'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 261FA626-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: M02281
  name: Eliminating intersections in drawings of graphs
publication_identifier:
  isbn:
  - 978-3-95977-066-8
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '7735'
quality_controlled: '1'
scopus_import: 1
status: public
title: Hanani-Tutte for approximating maps of graphs
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 99
year: '2018'
...
---
_id: '186'
abstract:
- lang: eng
  text: 'A drawing of a graph on a surface is independently even if every pair of
    nonadjacent edges in the drawing crosses an even number of times. The ℤ2-genus
    of a graph G is the minimum g such that G has an independently even drawing on
    the orientable surface of genus g. An unpublished result by Robertson and Seymour
    implies that for every t, every graph of sufficiently large genus contains as
    a minor a projective t × t grid or one of the following so-called t-Kuratowski
    graphs: K3, t, or t copies of K5 or K3,3 sharing at most 2 common vertices. We
    show that the ℤ2-genus of graphs in these families is unbounded in t; in fact,
    equal to their genus. Together, this implies that the genus of a graph is bounded
    from above by a function of its ℤ2-genus, solving a problem posed by Schaefer
    and Štefankovič, and giving an approximate version of the Hanani-Tutte theorem
    on orientable surfaces.'
alternative_title:
- LIPIcs
article_processing_charge: No
arxiv: 1
author:
- first_name: Radoslav
  full_name: Fulek, Radoslav
  id: 39F3FFE4-F248-11E8-B48F-1D18A9856A87
  last_name: Fulek
  orcid: 0000-0001-8485-1774
- first_name: Jan
  full_name: Kynčl, Jan
  last_name: Kynčl
citation:
  ama: 'Fulek R, Kynčl J. The ℤ2-Genus of Kuratowski minors. In: Vol 99. Schloss Dagstuhl
    - Leibniz-Zentrum für Informatik; 2018:40.1-40.14. doi:<a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.40">10.4230/LIPIcs.SoCG.2018.40</a>'
  apa: 'Fulek, R., &#38; Kynčl, J. (2018). The ℤ2-Genus of Kuratowski minors (Vol.
    99, p. 40.1-40.14). Presented at the SoCG: Symposium on Computational Geometry,
    Budapest, Hungary: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.40">https://doi.org/10.4230/LIPIcs.SoCG.2018.40</a>'
  chicago: Fulek, Radoslav, and Jan Kynčl. “The ℤ2-Genus of Kuratowski Minors,” 99:40.1-40.14.
    Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2018. <a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.40">https://doi.org/10.4230/LIPIcs.SoCG.2018.40</a>.
  ieee: 'R. Fulek and J. Kynčl, “The ℤ2-Genus of Kuratowski minors,” presented at
    the SoCG: Symposium on Computational Geometry, Budapest, Hungary, 2018, vol. 99,
    p. 40.1-40.14.'
  ista: 'Fulek R, Kynčl J. 2018. The ℤ2-Genus of Kuratowski minors. SoCG: Symposium
    on Computational Geometry, LIPIcs, vol. 99, 40.1-40.14.'
  mla: Fulek, Radoslav, and Jan Kynčl. <i>The ℤ2-Genus of Kuratowski Minors</i>. Vol.
    99, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2018, p. 40.1-40.14, doi:<a
    href="https://doi.org/10.4230/LIPIcs.SoCG.2018.40">10.4230/LIPIcs.SoCG.2018.40</a>.
  short: R. Fulek, J. Kynčl, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2018, p. 40.1-40.14.
conference:
  end_date: 2018-06-14
  location: Budapest, Hungary
  name: 'SoCG: Symposium on Computational Geometry'
  start_date: 2018-06-11
date_created: 2018-12-11T11:45:05Z
date_published: 2018-06-11T00:00:00Z
date_updated: 2025-04-14T13:52:37Z
day: '11'
department:
- _id: UlWa
doi: 10.4230/LIPIcs.SoCG.2018.40
external_id:
  arxiv:
  - '1803.05085'
fulldoi: https://doi.org/10.4230/LIPIcs.SoCG.2018.40
intvolume: '        99'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1803.05085
month: '06'
oa: 1
oa_version: Submitted Version
page: 40.1 - 40.14
project:
- _id: 261FA626-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: M02281
  name: Eliminating intersections in drawings of graphs
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '7734'
quality_controlled: '1'
related_material:
  record:
  - id: '11593'
    relation: later_version
    status: public
scopus_import: '1'
status: public
title: The ℤ2-Genus of Kuratowski minors
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 99
year: '2018'
...
---
_id: '187'
abstract:
- lang: eng
  text: 'Given a locally finite X ⊆ ℝd and a radius r ≥ 0, the k-fold cover of X and
    r consists of all points in ℝd that have k or more points of X within distance
    r. We consider two filtrations - one in scale obtained by fixing k and increasing
    r, and the other in depth obtained by fixing r and decreasing k - and we compute
    the persistence diagrams of both. While standard methods suffice for the filtration
    in scale, we need novel geometric and topological concepts for the filtration
    in depth. In particular, we introduce a rhomboid tiling in ℝd+1 whose horizontal
    integer slices are the order-k Delaunay mosaics of X, and construct a zigzag module
    from Delaunay mosaics that is isomorphic to the persistence module of the multi-covers. '
acknowledgement: This work is partially supported by the DFG Collaborative Research
  Center TRR 109, ‘Discretization in Geometry and Dynamics’, through grant no. I02979-N35
  of the Austrian Science Fund (FWF).
alternative_title:
- LIPIcs
article_number: '34'
author:
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Georg F
  full_name: Osang, Georg F
  id: 464B40D6-F248-11E8-B48F-1D18A9856A87
  last_name: Osang
  orcid: 0000-0002-8882-5116
citation:
  ama: 'Edelsbrunner H, Osang GF. The multi-cover persistence of Euclidean balls.
    In: Vol 99. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2018. doi:<a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.34">10.4230/LIPIcs.SoCG.2018.34</a>'
  apa: 'Edelsbrunner, H., &#38; Osang, G. F. (2018). The multi-cover persistence of
    Euclidean balls (Vol. 99). Presented at the SoCG: Symposium on Computational Geometry,
    Budapest, Hungary: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.34">https://doi.org/10.4230/LIPIcs.SoCG.2018.34</a>'
  chicago: Edelsbrunner, Herbert, and Georg F Osang. “The Multi-Cover Persistence
    of Euclidean Balls,” Vol. 99. Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2018. <a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.34">https://doi.org/10.4230/LIPIcs.SoCG.2018.34</a>.
  ieee: 'H. Edelsbrunner and G. F. Osang, “The multi-cover persistence of Euclidean
    balls,” presented at the SoCG: Symposium on Computational Geometry, Budapest,
    Hungary, 2018, vol. 99.'
  ista: 'Edelsbrunner H, Osang GF. 2018. The multi-cover persistence of Euclidean
    balls. SoCG: Symposium on Computational Geometry, LIPIcs, vol. 99, 34.'
  mla: Edelsbrunner, Herbert, and Georg F. Osang. <i>The Multi-Cover Persistence of
    Euclidean Balls</i>. Vol. 99, 34, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2018, doi:<a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.34">10.4230/LIPIcs.SoCG.2018.34</a>.
  short: H. Edelsbrunner, G.F. Osang, in:, Schloss Dagstuhl - Leibniz-Zentrum für
    Informatik, 2018.
conference:
  end_date: 2018-06-14
  location: Budapest, Hungary
  name: 'SoCG: Symposium on Computational Geometry'
  start_date: 2018-06-11
date_created: 2018-12-11T11:45:05Z
date_published: 2018-06-11T00:00:00Z
date_updated: 2026-04-08T07:01:29Z
day: '11'
ddc:
- '516'
department:
- _id: HeEd
doi: 10.4230/LIPIcs.SoCG.2018.34
file:
- access_level: open_access
  checksum: d8c0533ad0018eb4ed1077475eb8fc18
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-18T09:27:22Z
  date_updated: 2020-07-14T12:45:19Z
  file_id: '5738'
  file_name: 2018_LIPIcs_Edelsbrunner_Osang.pdf
  file_size: 528018
  relation: main_file
file_date_updated: 2020-07-14T12:45:19Z
fulldoi: https://doi.org/10.4230/LIPIcs.SoCG.2018.34
has_accepted_license: '1'
intvolume: '        99'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
project:
- _id: 2561EBF4-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I02979-N35
  name: Persistence and stability of geometric complexes
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '7732'
quality_controlled: '1'
related_material:
  record:
  - id: '9317'
    relation: later_version
    status: public
  - id: '9056'
    relation: dissertation_contains
    status: public
scopus_import: 1
status: public
title: The multi-cover persistence of Euclidean balls
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 99
year: '2018'
...
---
_id: '188'
abstract:
- lang: eng
  text: Smallest enclosing spheres of finite point sets are central to methods in
    topological data analysis. Focusing on Bregman divergences to measure dissimilarity,
    we prove bounds on the location of the center of a smallest enclosing sphere.
    These bounds depend on the range of radii for which Bregman balls are convex.
acknowledgement: This research is partially supported by the Office of Naval Research,
  through grant no. N62909-18-1-2038, and the DFG Collaborative Research Center TRR
  109, ‘Discretization in Geometry and Dynamics’, through grant no. I02979-N35 of
  the Austrian Science Fund
alternative_title:
- Leibniz International Proceedings in Information, LIPIcs
author:
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Ziga
  full_name: Virk, Ziga
  last_name: Virk
- first_name: Hubert
  full_name: Wagner, Hubert
  id: 379CA8B8-F248-11E8-B48F-1D18A9856A87
  last_name: Wagner
citation:
  ama: 'Edelsbrunner H, Virk Z, Wagner H. Smallest enclosing spheres and Chernoff
    points in Bregman geometry. In: Vol 99. Schloss Dagstuhl - Leibniz-Zentrum für
    Informatik; 2018:35:1-35:13. doi:<a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.35">10.4230/LIPIcs.SoCG.2018.35</a>'
  apa: 'Edelsbrunner, H., Virk, Z., &#38; Wagner, H. (2018). Smallest enclosing spheres
    and Chernoff points in Bregman geometry (Vol. 99, p. 35:1-35:13). Presented at
    the SoCG: Symposium on Computational Geometry, Budapest, Hungary: Schloss Dagstuhl
    - Leibniz-Zentrum für Informatik. <a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.35">https://doi.org/10.4230/LIPIcs.SoCG.2018.35</a>'
  chicago: Edelsbrunner, Herbert, Ziga Virk, and Hubert Wagner. “Smallest Enclosing
    Spheres and Chernoff Points in Bregman Geometry,” 99:35:1-35:13. Schloss Dagstuhl
    - Leibniz-Zentrum für Informatik, 2018. <a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.35">https://doi.org/10.4230/LIPIcs.SoCG.2018.35</a>.
  ieee: 'H. Edelsbrunner, Z. Virk, and H. Wagner, “Smallest enclosing spheres and
    Chernoff points in Bregman geometry,” presented at the SoCG: Symposium on Computational
    Geometry, Budapest, Hungary, 2018, vol. 99, p. 35:1-35:13.'
  ista: 'Edelsbrunner H, Virk Z, Wagner H. 2018. Smallest enclosing spheres and Chernoff
    points in Bregman geometry. SoCG: Symposium on Computational Geometry, Leibniz
    International Proceedings in Information, LIPIcs, vol. 99, 35:1-35:13.'
  mla: Edelsbrunner, Herbert, et al. <i>Smallest Enclosing Spheres and Chernoff Points
    in Bregman Geometry</i>. Vol. 99, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2018, p. 35:1-35:13, doi:<a href="https://doi.org/10.4230/LIPIcs.SoCG.2018.35">10.4230/LIPIcs.SoCG.2018.35</a>.
  short: H. Edelsbrunner, Z. Virk, H. Wagner, in:, Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik, 2018, p. 35:1-35:13.
conference:
  end_date: 2018-06-14
  location: Budapest, Hungary
  name: 'SoCG: Symposium on Computational Geometry'
  start_date: 2018-06-11
date_created: 2018-12-11T11:45:05Z
date_published: 2018-06-11T00:00:00Z
date_updated: 2021-01-12T06:53:48Z
day: '11'
ddc:
- '000'
department:
- _id: HeEd
doi: 10.4230/LIPIcs.SoCG.2018.35
file:
- access_level: open_access
  checksum: 7509403803b3ac1aee94bbc2ad293d21
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T16:31:31Z
  date_updated: 2020-07-14T12:45:20Z
  file_id: '5724'
  file_name: 2018_LIPIcs_Edelsbrunner.pdf
  file_size: 489080
  relation: main_file
file_date_updated: 2020-07-14T12:45:20Z
fulldoi: https://doi.org/10.4230/LIPIcs.SoCG.2018.35
has_accepted_license: '1'
intvolume: '        99'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 35:1 - 35:13
project:
- _id: 2561EBF4-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I02979-N35
  name: Persistence and stability of geometric complexes
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '7733'
quality_controlled: '1'
scopus_import: 1
status: public
title: Smallest enclosing spheres and Chernoff points in Bregman geometry
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 99
year: '2018'
...
---
_id: '19'
abstract:
- lang: eng
  text: Bacteria regulate genes to survive antibiotic stress, but regulation can be
    far from perfect. When regulation is not optimal, mutations that change gene expression
    can contribute to antibiotic resistance. It is not systematically understood to
    what extent natural gene regulation is or is not optimal for distinct antibiotics,
    and how changes in expression of specific genes quantitatively affect antibiotic
    resistance. Here we discover a simple quantitative relation between fitness, gene
    expression, and antibiotic potency, which rationalizes our observation that a
    multitude of genes and even innate antibiotic defense mechanisms have expression
    that is critically nonoptimal under antibiotic treatment. First, we developed
    a pooled-strain drug-diffusion assay and screened Escherichia coli overexpression
    and knockout libraries, finding that resistance to a range of 31 antibiotics could
    result from changing expression of a large and functionally diverse set of genes,
    in a primarily but not exclusively drug-specific manner. Second, by synthetically
    controlling the expression of single-drug and multidrug resistance genes, we observed
    that their fitness-expression functions changed dramatically under antibiotic
    treatment in accordance with a log-sensitivity relation. Thus, because many genes
    are nonoptimally expressed under antibiotic treatment, many regulatory mutations
    can contribute to resistance by altering expression and by activating latent defenses.
article_processing_charge: No
article_type: original
author:
- first_name: Adam
  full_name: Palmer, Adam
  last_name: Palmer
- first_name: Remy P
  full_name: Chait, Remy P
  id: 3464AE84-F248-11E8-B48F-1D18A9856A87
  last_name: Chait
  orcid: 0000-0003-0876-3187
- first_name: Roy
  full_name: Kishony, Roy
  last_name: Kishony
citation:
  ama: Palmer A, Chait RP, Kishony R. Nonoptimal gene expression creates latent potential
    for antibiotic resistance. <i>Molecular Biology and Evolution</i>. 2018;35(11):2669-2684.
    doi:<a href="https://doi.org/10.1093/molbev/msy163">10.1093/molbev/msy163</a>
  apa: Palmer, A., Chait, R. P., &#38; Kishony, R. (2018). Nonoptimal gene expression
    creates latent potential for antibiotic resistance. <i>Molecular Biology and Evolution</i>.
    Oxford University Press. <a href="https://doi.org/10.1093/molbev/msy163">https://doi.org/10.1093/molbev/msy163</a>
  chicago: Palmer, Adam, Remy P Chait, and Roy Kishony. “Nonoptimal Gene Expression
    Creates Latent Potential for Antibiotic Resistance.” <i>Molecular Biology and
    Evolution</i>. Oxford University Press, 2018. <a href="https://doi.org/10.1093/molbev/msy163">https://doi.org/10.1093/molbev/msy163</a>.
  ieee: A. Palmer, R. P. Chait, and R. Kishony, “Nonoptimal gene expression creates
    latent potential for antibiotic resistance,” <i>Molecular Biology and Evolution</i>,
    vol. 35, no. 11. Oxford University Press, pp. 2669–2684, 2018.
  ista: Palmer A, Chait RP, Kishony R. 2018. Nonoptimal gene expression creates latent
    potential for antibiotic resistance. Molecular Biology and Evolution. 35(11),
    2669–2684.
  mla: Palmer, Adam, et al. “Nonoptimal Gene Expression Creates Latent Potential for
    Antibiotic Resistance.” <i>Molecular Biology and Evolution</i>, vol. 35, no. 11,
    Oxford University Press, 2018, pp. 2669–84, doi:<a href="https://doi.org/10.1093/molbev/msy163">10.1093/molbev/msy163</a>.
  short: A. Palmer, R.P. Chait, R. Kishony, Molecular Biology and Evolution 35 (2018)
    2669–2684.
date_created: 2018-12-11T11:44:11Z
date_published: 2018-08-28T00:00:00Z
date_updated: 2023-10-17T11:51:06Z
day: '28'
department:
- _id: CaGu
- _id: GaTk
doi: 10.1093/molbev/msy163
external_id:
  isi:
  - '000452567200006'
  pmid:
  - '30169679'
fulldoi: https://doi.org/10.1093/molbev/msy163
intvolume: '        35'
isi: 1
issue: '11'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pubmed/30169679
month: '08'
oa: 1
oa_version: Submitted Version
page: 2669 - 2684
pmid: 1
publication: Molecular Biology and Evolution
publication_identifier:
  issn:
  - 0737-4038
publication_status: published
publisher: Oxford University Press
publist_id: '8036'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nonoptimal gene expression creates latent potential for antibiotic resistance
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 35
year: '2018'
...
---
_id: '190'
abstract:
- lang: eng
  text: The German cockroach, Blattella germanica, is a worldwide pest that infests
    buildings, including homes, restaurants, and hospitals, often living in unsanitary
    conditions. As a disease vector and producer of allergens, this species has major
    health and economic impacts on humans. Factors contributing to the success of
    the German cockroach include its resistance to a broad range of insecticides,
    immunity to many pathogens, and its ability, as an extreme generalist omnivore,
    to survive on most food sources. The recently published genome shows that B. germanica
    has an exceptionally high number of protein coding genes. In this study, we investigate
    the functions of the 93 significantly expanded gene families with the aim to better
    understand the success of B. germanica as a major pest despite such inhospitable
    conditions. We find major expansions in gene families with functions related to
    the detoxification of insecticides and allelochemicals, defense against pathogens,
    digestion, sensory perception, and gene regulation. These expansions might have
    allowed B. germanica to develop multiple resistance mechanisms to insecticides
    and pathogens, and enabled a broad, flexible diet, thus explaining its success
    in unsanitary conditions and under recurrent chemical control. The findings and
    resources presented here provide insights for better understanding molecular mechanisms
    that will facilitate more effective cockroach control.
article_processing_charge: No
article_type: original
author:
- first_name: Mark
  full_name: Harrison, Mark
  last_name: Harrison
- first_name: Nicolas
  full_name: Arning, Nicolas
  last_name: Arning
- first_name: Lucas
  full_name: Kremer, Lucas
  last_name: Kremer
- first_name: Guillem
  full_name: Ylla, Guillem
  last_name: Ylla
- first_name: Xavier
  full_name: Belles, Xavier
  last_name: Belles
- first_name: Erich
  full_name: Bornberg Bauer, Erich
  last_name: Bornberg Bauer
- first_name: Ann K
  full_name: Huylmans, Ann K
  id: 4C0A3874-F248-11E8-B48F-1D18A9856A87
  last_name: Huylmans
  orcid: 0000-0001-8871-4961
- first_name: Evelien
  full_name: Jongepier, Evelien
  last_name: Jongepier
- first_name: Maria
  full_name: Puilachs, Maria
  last_name: Puilachs
- first_name: Stephen
  full_name: Richards, Stephen
  last_name: Richards
- first_name: Coby
  full_name: Schal, Coby
  last_name: Schal
citation:
  ama: 'Harrison M, Arning N, Kremer L, et al. Expansions of key protein families
    in the German cockroach highlight the molecular basis of its remarkable success
    as a global indoor pest. <i>Journal of Experimental Zoology Part B: Molecular
    and Developmental Evolution</i>. 2018;330:254-264. doi:<a href="https://doi.org/10.1002/jez.b.22824">10.1002/jez.b.22824</a>'
  apa: 'Harrison, M., Arning, N., Kremer, L., Ylla, G., Belles, X., Bornberg Bauer,
    E., … Schal, C. (2018). Expansions of key protein families in the German cockroach
    highlight the molecular basis of its remarkable success as a global indoor pest.
    <i>Journal of Experimental Zoology Part B: Molecular and Developmental Evolution</i>.
    Wiley. <a href="https://doi.org/10.1002/jez.b.22824">https://doi.org/10.1002/jez.b.22824</a>'
  chicago: 'Harrison, Mark, Nicolas Arning, Lucas Kremer, Guillem Ylla, Xavier Belles,
    Erich Bornberg Bauer, Ann K Huylmans, et al. “Expansions of Key Protein Families
    in the German Cockroach Highlight the Molecular Basis of Its Remarkable Success
    as a Global Indoor Pest.” <i>Journal of Experimental Zoology Part B: Molecular
    and Developmental Evolution</i>. Wiley, 2018. <a href="https://doi.org/10.1002/jez.b.22824">https://doi.org/10.1002/jez.b.22824</a>.'
  ieee: 'M. Harrison <i>et al.</i>, “Expansions of key protein families in the German
    cockroach highlight the molecular basis of its remarkable success as a global
    indoor pest,” <i>Journal of Experimental Zoology Part B: Molecular and Developmental
    Evolution</i>, vol. 330. Wiley, pp. 254–264, 2018.'
  ista: 'Harrison M, Arning N, Kremer L, Ylla G, Belles X, Bornberg Bauer E, Huylmans
    AK, Jongepier E, Puilachs M, Richards S, Schal C. 2018. Expansions of key protein
    families in the German cockroach highlight the molecular basis of its remarkable
    success as a global indoor pest. Journal of Experimental Zoology Part B: Molecular
    and Developmental Evolution. 330, 254–264.'
  mla: 'Harrison, Mark, et al. “Expansions of Key Protein Families in the German Cockroach
    Highlight the Molecular Basis of Its Remarkable Success as a Global Indoor Pest.”
    <i>Journal of Experimental Zoology Part B: Molecular and Developmental Evolution</i>,
    vol. 330, Wiley, 2018, pp. 254–64, doi:<a href="https://doi.org/10.1002/jez.b.22824">10.1002/jez.b.22824</a>.'
  short: 'M. Harrison, N. Arning, L. Kremer, G. Ylla, X. Belles, E. Bornberg Bauer,
    A.K. Huylmans, E. Jongepier, M. Puilachs, S. Richards, C. Schal, Journal of Experimental
    Zoology Part B: Molecular and Developmental Evolution 330 (2018) 254–264.'
date_created: 2018-12-11T11:45:06Z
date_published: 2018-07-11T00:00:00Z
date_updated: 2023-09-11T13:59:54Z
day: '11'
department:
- _id: BeVi
doi: 10.1002/jez.b.22824
external_id:
  isi:
  - '000443231000002'
  pmid:
  - '29998472'
fulldoi: https://doi.org/10.1002/jez.b.22824
intvolume: '       330'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://onlinelibrary.wiley.com/doi/am-pdf/10.1002/jez.b.22824
month: '07'
oa: 1
oa_version: Submitted Version
page: 254-264
pmid: 1
publication: 'Journal of Experimental Zoology Part B: Molecular and Developmental
  Evolution'
publication_status: published
publisher: Wiley
publist_id: '7730'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Expansions of key protein families in the German cockroach highlight the molecular
  basis of its remarkable success as a global indoor pest
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 330
year: '2018'
...
---
_id: '192'
abstract:
- lang: eng
  text: The phytohormone auxin is the information carrier in a plethora of developmental
    and physiological processes in plants(1). It has been firmly established that
    canonical, nuclear auxin signalling acts through regulation of gene transcription(2).
    Here, we combined microfluidics, live imaging, genetic engineering and computational
    modelling to reanalyse the classical case of root growth inhibition(3) by auxin.
    We show that Arabidopsis roots react to addition and removal of auxin by extremely
    rapid adaptation of growth rate. This process requires intracellular auxin perception
    but not transcriptional reprogramming. The formation of the canonical TIR1/AFB-Aux/IAA
    co-receptor complex is required for the growth regulation, hinting to a novel,
    non-transcriptional branch of this signalling pathway. Our results challenge the
    current understanding of root growth regulation by auxin and suggest another,
    presumably non-transcriptional, signalling output of the canonical auxin pathway.
article_processing_charge: No
article_type: original
author:
- first_name: Matyas
  full_name: Fendrych, Matyas
  id: 43905548-F248-11E8-B48F-1D18A9856A87
  last_name: Fendrych
  orcid: 0000-0002-9767-8699
- first_name: Maria
  full_name: Akhmanova, Maria
  id: 3425EC26-F248-11E8-B48F-1D18A9856A87
  last_name: Akhmanova
  orcid: 0000-0003-1522-3162
- first_name: Jack
  full_name: Merrin, Jack
  id: 4515C308-F248-11E8-B48F-1D18A9856A87
  last_name: Merrin
  orcid: 0000-0001-5145-4609
- first_name: Matous
  full_name: Glanc, Matous
  last_name: Glanc
- first_name: Shinya
  full_name: Hagihara, Shinya
  last_name: Hagihara
- first_name: Koji
  full_name: Takahashi, Koji
  last_name: Takahashi
- first_name: Naoyuki
  full_name: Uchida, Naoyuki
  last_name: Uchida
- first_name: Keiko U
  full_name: Torii, Keiko U
  last_name: Torii
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
citation:
  ama: Fendrych M, Akhmanova M, Merrin J, et al. Rapid and reversible root growth
    inhibition by TIR1 auxin signalling. <i>Nature Plants</i>. 2018;4(7):453-459.
    doi:<a href="https://doi.org/10.1038/s41477-018-0190-1">10.1038/s41477-018-0190-1</a>
  apa: Fendrych, M., Akhmanova, M., Merrin, J., Glanc, M., Hagihara, S., Takahashi,
    K., … Friml, J. (2018). Rapid and reversible root growth inhibition by TIR1 auxin
    signalling. <i>Nature Plants</i>. Springer Nature. <a href="https://doi.org/10.1038/s41477-018-0190-1">https://doi.org/10.1038/s41477-018-0190-1</a>
  chicago: Fendrych, Matyas, Maria Akhmanova, Jack Merrin, Matous Glanc, Shinya Hagihara,
    Koji Takahashi, Naoyuki Uchida, Keiko U Torii, and Jiří Friml. “Rapid and Reversible
    Root Growth Inhibition by TIR1 Auxin Signalling.” <i>Nature Plants</i>. Springer
    Nature, 2018. <a href="https://doi.org/10.1038/s41477-018-0190-1">https://doi.org/10.1038/s41477-018-0190-1</a>.
  ieee: M. Fendrych <i>et al.</i>, “Rapid and reversible root growth inhibition by
    TIR1 auxin signalling,” <i>Nature Plants</i>, vol. 4, no. 7. Springer Nature,
    pp. 453–459, 2018.
  ista: Fendrych M, Akhmanova M, Merrin J, Glanc M, Hagihara S, Takahashi K, Uchida
    N, Torii KU, Friml J. 2018. Rapid and reversible root growth inhibition by TIR1
    auxin signalling. Nature Plants. 4(7), 453–459.
  mla: Fendrych, Matyas, et al. “Rapid and Reversible Root Growth Inhibition by TIR1
    Auxin Signalling.” <i>Nature Plants</i>, vol. 4, no. 7, Springer Nature, 2018,
    pp. 453–59, doi:<a href="https://doi.org/10.1038/s41477-018-0190-1">10.1038/s41477-018-0190-1</a>.
  short: M. Fendrych, M. Akhmanova, J. Merrin, M. Glanc, S. Hagihara, K. Takahashi,
    N. Uchida, K.U. Torii, J. Friml, Nature Plants 4 (2018) 453–459.
date_created: 2018-12-11T11:45:07Z
date_published: 2018-06-25T00:00:00Z
date_updated: 2023-09-15T12:11:03Z
day: '25'
department:
- _id: JiFr
- _id: DaSi
- _id: NanoFab
doi: 10.1038/s41477-018-0190-1
external_id:
  isi:
  - '000443221200017'
  pmid:
  - '29942048'
fulldoi: https://doi.org/10.1038/s41477-018-0190-1
intvolume: '         4'
isi: 1
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pubmed/29942048
month: '06'
oa: 1
oa_version: Submitted Version
page: 453 - 459
pmid: 1
publication: Nature Plants
publication_status: published
publisher: Springer Nature
publist_id: '7728'
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/new-mechanism-for-the-plant-hormone-auxin-discovered/
scopus_import: '1'
status: public
title: Rapid and reversible root growth inhibition by TIR1 auxin signalling
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 4
year: '2018'
...
---
_id: '193'
abstract:
- lang: eng
  text: 'We show attacks on five data-independent memory-hard functions (iMHF) that
    were submitted to the password hashing competition (PHC). Informally, an MHF is
    a function which cannot be evaluated on dedicated hardware, like ASICs, at significantly
    lower hardware and/or energy cost than evaluating a single instance on a standard
    single-core architecture. Data-independent means the memory access pattern of
    the function is independent of the input; this makes iMHFs harder to construct
    than data-dependent ones, but the latter can be attacked by various side-channel
    attacks. Following [Alwen-Blocki''16], we capture the evaluation of an iMHF as
    a directed acyclic graph (DAG). The cumulative parallel pebbling complexity of
    this DAG is a measure for the hardware cost of evaluating the iMHF on an ASIC.
    Ideally, one would like the complexity of a DAG underlying an iMHF to be as close
    to quadratic in the number of nodes of the graph as possible. Instead, we show
    that (the DAGs underlying) the following iMHFs are far from this bound: Rig.v2,
    TwoCats and Gambit each having an exponent no more than 1.75. Moreover, we show
    that the complexity of the iMHF modes of the PHC finalists Pomelo and Lyra2 have
    exponents at most 1.83 and 1.67 respectively. To show this we investigate a combinatorial
    property of each underlying DAG (called its depth-robustness. By establishing
    upper bounds on this property we are then able to apply the general technique
    of [Alwen-Block''16] for analyzing the hardware costs of an iMHF.'
acknowledgement: Leonid Reyzin was supported in part by IST Austria and by US NSF
  grants 1012910, 1012798, and 1422965; this research was performed while he was visiting
  IST Austria.
article_processing_charge: No
author:
- first_name: Joel F
  full_name: Alwen, Joel F
  id: 2A8DFA8C-F248-11E8-B48F-1D18A9856A87
  last_name: Alwen
- first_name: Peter
  full_name: Gazi, Peter
  last_name: Gazi
- first_name: Chethan
  full_name: Kamath Hosdurg, Chethan
  id: 4BD3F30E-F248-11E8-B48F-1D18A9856A87
  last_name: Kamath Hosdurg
- first_name: Karen
  full_name: Klein, Karen
  id: 3E83A2F8-F248-11E8-B48F-1D18A9856A87
  last_name: Klein
- first_name: Georg F
  full_name: Osang, Georg F
  id: 464B40D6-F248-11E8-B48F-1D18A9856A87
  last_name: Osang
  orcid: 0000-0002-8882-5116
- first_name: Krzysztof Z
  full_name: Pietrzak, Krzysztof Z
  id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
  last_name: Pietrzak
  orcid: 0000-0002-9139-1654
- first_name: Lenoid
  full_name: Reyzin, Lenoid
  last_name: Reyzin
- first_name: Michal
  full_name: Rolinek, Michal
  id: 3CB3BC06-F248-11E8-B48F-1D18A9856A87
  last_name: Rolinek
- first_name: Michal
  full_name: Rybar, Michal
  id: 2B3E3DE8-F248-11E8-B48F-1D18A9856A87
  last_name: Rybar
citation:
  ama: 'Alwen JF, Gazi P, Kamath Hosdurg C, et al. On the memory hardness of data
    independent password hashing functions. In: <i>Proceedings of the 2018 on Asia
    Conference on Computer and Communication Security</i>. ACM; 2018:51-65. doi:<a
    href="https://doi.org/10.1145/3196494.3196534">10.1145/3196494.3196534</a>'
  apa: 'Alwen, J. F., Gazi, P., Kamath Hosdurg, C., Klein, K., Osang, G. F., Pietrzak,
    K. Z., … Rybar, M. (2018). On the memory hardness of data independent password
    hashing functions. In <i>Proceedings of the 2018 on Asia Conference on Computer
    and Communication Security</i> (pp. 51–65). Incheon, Republic of Korea: ACM. <a
    href="https://doi.org/10.1145/3196494.3196534">https://doi.org/10.1145/3196494.3196534</a>'
  chicago: Alwen, Joel F, Peter Gazi, Chethan Kamath Hosdurg, Karen Klein, Georg F
    Osang, Krzysztof Z Pietrzak, Lenoid Reyzin, Michal Rolinek, and Michal Rybar.
    “On the Memory Hardness of Data Independent Password Hashing Functions.” In <i>Proceedings
    of the 2018 on Asia Conference on Computer and Communication Security</i>, 51–65.
    ACM, 2018. <a href="https://doi.org/10.1145/3196494.3196534">https://doi.org/10.1145/3196494.3196534</a>.
  ieee: J. F. Alwen <i>et al.</i>, “On the memory hardness of data independent password
    hashing functions,” in <i>Proceedings of the 2018 on Asia Conference on Computer
    and Communication Security</i>, Incheon, Republic of Korea, 2018, pp. 51–65.
  ista: 'Alwen JF, Gazi P, Kamath Hosdurg C, Klein K, Osang GF, Pietrzak KZ, Reyzin
    L, Rolinek M, Rybar M. 2018. On the memory hardness of data independent password
    hashing functions. Proceedings of the 2018 on Asia Conference on Computer and
    Communication Security. ASIACCS: Asia Conference on Computer and Communications
    Security , 51–65.'
  mla: Alwen, Joel F., et al. “On the Memory Hardness of Data Independent Password
    Hashing Functions.” <i>Proceedings of the 2018 on Asia Conference on Computer
    and Communication Security</i>, ACM, 2018, pp. 51–65, doi:<a href="https://doi.org/10.1145/3196494.3196534">10.1145/3196494.3196534</a>.
  short: J.F. Alwen, P. Gazi, C. Kamath Hosdurg, K. Klein, G.F. Osang, K.Z. Pietrzak,
    L. Reyzin, M. Rolinek, M. Rybar, in:, Proceedings of the 2018 on Asia Conference
    on Computer and Communication Security, ACM, 2018, pp. 51–65.
conference:
  end_date: 2018-06-08
  location: Incheon, Republic of Korea
  name: 'ASIACCS: Asia Conference on Computer and Communications Security '
  start_date: 2018-06-04
date_created: 2018-12-11T11:45:07Z
date_published: 2018-06-01T00:00:00Z
date_updated: 2024-11-04T13:52:29Z
day: '01'
department:
- _id: KrPi
- _id: HeEd
- _id: VlKo
doi: 10.1145/3196494.3196534
ec_funded: 1
external_id:
  isi:
  - '000516620100005'
fulldoi: https://doi.org/10.1145/3196494.3196534
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://eprint.iacr.org/2016/783
month: '06'
oa: 1
oa_version: Submitted Version
page: 51 - 65
project:
- _id: 25FBA906-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '616160'
  name: 'Discrete Optimization in Computer Vision: Theory and Practice'
- _id: 258AA5B2-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '682815'
  name: Teaching Old Crypto New Tricks
publication: Proceedings of the 2018 on Asia Conference on Computer and Communication
  Security
publication_status: published
publisher: ACM
publist_id: '7723'
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the memory hardness of data independent password hashing functions
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2018'
...
