---
OA_place: repository
OA_type: green
_id: '19815'
abstract:
- lang: eng
text: We report growth of single crystals of the nonmagnetic metallic delafossite
PdRhO2, comparing the results from three different methods. Complete crystallographic
data were obtained from single crystal X-ray diffraction, and electronic structure
calculations were made using the refined structural parameters. Focused-ion beam
microstructuring was used to prepare a sample for measurements of the in- and
out-of-plane electrical resistivity, and the large observed anisotropy is qualitatively
consistent with the cylindrical Fermi surface predicted by the calculations.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: P.
full_name: Kushwaha, P.
last_name: Kushwaha
- first_name: H.
full_name: Borrmann, H.
last_name: Borrmann
- first_name: S.
full_name: Khim, S.
last_name: Khim
- first_name: H.
full_name: Rosner, H.
last_name: Rosner
- first_name: P. J. W.
full_name: Moll, P. J. W.
last_name: Moll
- first_name: D. A.
full_name: Sokolov, D. A.
last_name: Sokolov
- first_name: Veronika
full_name: Sunko, Veronika
id: 23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3
last_name: Sunko
orcid: 0000-0003-2724-3523
- first_name: Yu.
full_name: Grin, Yu.
last_name: Grin
- first_name: A. P.
full_name: Mackenzie, A. P.
last_name: Mackenzie
citation:
ama: Kushwaha P, Borrmann H, Khim S, et al. Single crystal growth, structure, and
electronic properties of metallic delafossite PdRhO2. Crystal Growth &
Design. 2017;17(8):4144-4150. doi:10.1021/acs.cgd.7b00418
apa: Kushwaha, P., Borrmann, H., Khim, S., Rosner, H., Moll, P. J. W., Sokolov,
D. A., … Mackenzie, A. P. (2017). Single crystal growth, structure, and electronic
properties of metallic delafossite PdRhO2. Crystal Growth & Design.
American Chemical Society. https://doi.org/10.1021/acs.cgd.7b00418
chicago: Kushwaha, P., H. Borrmann, S. Khim, H. Rosner, P. J. W. Moll, D. A. Sokolov,
Veronika Sunko, Yu. Grin, and A. P. Mackenzie. “Single Crystal Growth, Structure,
and Electronic Properties of Metallic Delafossite PdRhO2.” Crystal Growth &
Design. American Chemical Society, 2017. https://doi.org/10.1021/acs.cgd.7b00418.
ieee: P. Kushwaha et al., “Single crystal growth, structure, and electronic
properties of metallic delafossite PdRhO2,” Crystal Growth & Design,
vol. 17, no. 8. American Chemical Society, pp. 4144–4150, 2017.
ista: Kushwaha P, Borrmann H, Khim S, Rosner H, Moll PJW, Sokolov DA, Sunko V, Grin
Y, Mackenzie AP. 2017. Single crystal growth, structure, and electronic properties
of metallic delafossite PdRhO2. Crystal Growth & Design. 17(8), 4144–4150.
mla: Kushwaha, P., et al. “Single Crystal Growth, Structure, and Electronic Properties
of Metallic Delafossite PdRhO2.” Crystal Growth & Design, vol. 17,
no. 8, American Chemical Society, 2017, pp. 4144–50, doi:10.1021/acs.cgd.7b00418.
short: P. Kushwaha, H. Borrmann, S. Khim, H. Rosner, P.J.W. Moll, D.A. Sokolov,
V. Sunko, Y. Grin, A.P. Mackenzie, Crystal Growth & Design 17 (2017) 4144–4150.
date_created: 2025-06-10T09:16:10Z
date_published: 2017-06-30T00:00:00Z
date_updated: 2025-06-10T12:24:49Z
day: '30'
doi: 10.1021/acs.cgd.7b00418
extern: '1'
external_id:
arxiv:
- '1706.07614'
intvolume: ' 17'
issue: '8'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.1706.07614
month: '06'
oa: 1
oa_version: Preprint
page: 4144-4150
publication: Crystal Growth & Design
publication_identifier:
eissn:
- 1528-7505
issn:
- 1528-7483
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Single crystal growth, structure, and electronic properties of metallic delafossite
PdRhO2
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2017'
...
---
OA_place: repository
OA_type: green
_id: '19474'
abstract:
- lang: eng
text: The complex behaviors underlying reward seeking and consumption are integral
to organism survival. The hypothalamus and mesolimbic dopamine system are key
mediators of these behaviors, yet regulation of appetitive and consummatory behaviors
outside of these regions is poorly understood. The central nucleus of the amygdala
(CeA) has been implicated in feeding and reward, but the neurons and circuit mechanisms
that positively regulate these behaviors remain unclear. Here, we defined the
neuronal mechanisms by which CeA neurons promote food consumption. Using in vivo
activity manipulations and Ca2+ imaging in mice, we found that GABAergic serotonin
receptor 2a (Htr2a)-expressing CeA neurons modulate food consumption, promote
positive reinforcement and are active in vivo during eating. We demonstrated electrophysiologically,
anatomically and behaviorally that intra-CeA and long-range circuit mechanisms
underlie these behaviors. Finally, we showed that CeAHtr2a neurons receive inputs
from feeding-relevant brain regions. Our results illustrate how defined CeA neural
circuits positively regulate food consumption.
article_processing_charge: No
article_type: original
author:
- first_name: Amelia May Barnett
full_name: Douglass, Amelia May Barnett
id: de5f6fda-80fb-11ef-996f-a8c4ecd8e289
last_name: Douglass
orcid: 0000-0001-5398-6473
- first_name: Hakan
full_name: Kucukdereli, Hakan
last_name: Kucukdereli
- first_name: Marion
full_name: Ponserre, Marion
last_name: Ponserre
- first_name: Milica
full_name: Markovic, Milica
last_name: Markovic
- first_name: Jan
full_name: Gründemann, Jan
last_name: Gründemann
- first_name: Cornelia
full_name: Strobel, Cornelia
last_name: Strobel
- first_name: Pilar L
full_name: Alcala Morales, Pilar L
last_name: Alcala Morales
- first_name: Karl-Klaus
full_name: Conzelmann, Karl-Klaus
last_name: Conzelmann
- first_name: Andreas
full_name: Lüthi, Andreas
last_name: Lüthi
- first_name: Rüdiger
full_name: Klein, Rüdiger
last_name: Klein
citation:
ama: Douglass AM, Kucukdereli H, Ponserre M, et al. Central amygdala circuits modulate
food consumption through a positive-valence mechanism. Nature Neuroscience.
2017;20(10):1384-1394. doi:10.1038/nn.4623
apa: Douglass, A. M., Kucukdereli, H., Ponserre, M., Markovic, M., Gründemann, J.,
Strobel, C., … Klein, R. (2017). Central amygdala circuits modulate food consumption
through a positive-valence mechanism. Nature Neuroscience. Springer Nature.
https://doi.org/10.1038/nn.4623
chicago: Douglass, Amelia M., Hakan Kucukdereli, Marion Ponserre, Milica Markovic,
Jan Gründemann, Cornelia Strobel, Pilar L Alcala Morales, Karl-Klaus Conzelmann,
Andreas Lüthi, and Rüdiger Klein. “Central Amygdala Circuits Modulate Food Consumption
through a Positive-Valence Mechanism.” Nature Neuroscience. Springer Nature,
2017. https://doi.org/10.1038/nn.4623.
ieee: A. M. Douglass et al., “Central amygdala circuits modulate food consumption
through a positive-valence mechanism,” Nature Neuroscience, vol. 20, no.
10. Springer Nature, pp. 1384–1394, 2017.
ista: Douglass AM, Kucukdereli H, Ponserre M, Markovic M, Gründemann J, Strobel
C, Alcala Morales PL, Conzelmann K-K, Lüthi A, Klein R. 2017. Central amygdala
circuits modulate food consumption through a positive-valence mechanism. Nature
Neuroscience. 20(10), 1384–1394.
mla: Douglass, Amelia M., et al. “Central Amygdala Circuits Modulate Food Consumption
through a Positive-Valence Mechanism.” Nature Neuroscience, vol. 20, no.
10, Springer Nature, 2017, pp. 1384–94, doi:10.1038/nn.4623.
short: A.M. Douglass, H. Kucukdereli, M. Ponserre, M. Markovic, J. Gründemann, C.
Strobel, P.L. Alcala Morales, K.-K. Conzelmann, A. Lüthi, R. Klein, Nature Neuroscience
20 (2017) 1384–1394.
date_created: 2025-04-03T12:30:57Z
date_published: 2017-10-01T00:00:00Z
date_updated: 2025-07-10T11:51:42Z
day: '01'
doi: 10.1038/nn.4623
extern: '1'
external_id:
pmid:
- '28825719 '
intvolume: ' 20'
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/145375
month: '10'
oa: 1
oa_version: Preprint
page: 1384-1394
pmid: 1
publication: Nature Neuroscience
publication_identifier:
eissn:
- 1546-1726
issn:
- 1097-6256
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Central amygdala circuits modulate food consumption through a positive-valence
mechanism
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '2017'
...
---
_id: '15154'
abstract:
- lang: eng
text: Biofilm formation is critical for the infection cycle of Vibrio cholerae.
Vibrio exopolysaccharides (VPS) and the matrix proteins RbmA, Bap1 and RbmC are
required for the development of biofilm architecture. We demonstrate that RbmA
binds VPS directly and uses a binary structural switch within its first fibronectin
type III (FnIII-1) domain to control RbmA structural dynamics and the formation
of VPS-dependent higher-order structures. The structural switch in FnIII-1 regulates
interactions in trans with the FnIII-2 domain, leading to open (monomeric) or
closed (dimeric) interfaces. The ability of RbmA to switch between open and closed
states is important for V. cholerae biofilm formation, as RbmA variants with switches
that are locked in either of the two states lead to biofilms with altered architecture
and structural integrity.
article_number: '26163'
article_processing_charge: Yes
article_type: original
author:
- first_name: Jiunn CN
full_name: Fong, Jiunn CN
last_name: Fong
- first_name: Andrew
full_name: Rogers, Andrew
last_name: Rogers
- first_name: Alicia Kathleen
full_name: Michael, Alicia Kathleen
id: 6437c950-2a03-11ee-914d-d6476dd7b75c
last_name: Michael
- first_name: Nicole C
full_name: Parsley, Nicole C
last_name: Parsley
- first_name: William-Cole
full_name: Cornell, William-Cole
last_name: Cornell
- first_name: Yu-Cheng
full_name: Lin, Yu-Cheng
last_name: Lin
- first_name: Praveen K
full_name: Singh, Praveen K
last_name: Singh
- first_name: Raimo
full_name: Hartmann, Raimo
last_name: Hartmann
- first_name: Knut
full_name: Drescher, Knut
last_name: Drescher
- first_name: Evgeny
full_name: Vinogradov, Evgeny
last_name: Vinogradov
- first_name: Lars EP
full_name: Dietrich, Lars EP
last_name: Dietrich
- first_name: Carrie L
full_name: Partch, Carrie L
last_name: Partch
- first_name: Fitnat H
full_name: Yildiz, Fitnat H
last_name: Yildiz
citation:
ama: Fong JC, Rogers A, Michael AK, et al. Structural dynamics of RbmA governs plasticity
of Vibrio cholerae biofilms. eLife. 2017;6. doi:10.7554/elife.26163
apa: Fong, J. C., Rogers, A., Michael, A. K., Parsley, N. C., Cornell, W.-C., Lin,
Y.-C., … Yildiz, F. H. (2017). Structural dynamics of RbmA governs plasticity
of Vibrio cholerae biofilms. ELife. eLife Sciences Publications. https://doi.org/10.7554/elife.26163
chicago: Fong, Jiunn CN, Andrew Rogers, Alicia K. Michael, Nicole C Parsley, William-Cole
Cornell, Yu-Cheng Lin, Praveen K Singh, et al. “Structural Dynamics of RbmA Governs
Plasticity of Vibrio Cholerae Biofilms.” ELife. eLife Sciences Publications,
2017. https://doi.org/10.7554/elife.26163.
ieee: J. C. Fong et al., “Structural dynamics of RbmA governs plasticity
of Vibrio cholerae biofilms,” eLife, vol. 6. eLife Sciences Publications,
2017.
ista: Fong JC, Rogers A, Michael AK, Parsley NC, Cornell W-C, Lin Y-C, Singh PK,
Hartmann R, Drescher K, Vinogradov E, Dietrich LE, Partch CL, Yildiz FH. 2017.
Structural dynamics of RbmA governs plasticity of Vibrio cholerae biofilms. eLife.
6, 26163.
mla: Fong, Jiunn CN, et al. “Structural Dynamics of RbmA Governs Plasticity of Vibrio
Cholerae Biofilms.” ELife, vol. 6, 26163, eLife Sciences Publications,
2017, doi:10.7554/elife.26163.
short: J.C. Fong, A. Rogers, A.K. Michael, N.C. Parsley, W.-C. Cornell, Y.-C. Lin,
P.K. Singh, R. Hartmann, K. Drescher, E. Vinogradov, L.E. Dietrich, C.L. Partch,
F.H. Yildiz, ELife 6 (2017).
date_created: 2024-03-21T07:55:36Z
date_published: 2017-08-01T00:00:00Z
date_updated: 2024-03-25T12:22:54Z
day: '01'
doi: 10.7554/elife.26163
extern: '1'
external_id:
pmid:
- '28762945'
intvolume: ' 6'
keyword:
- General Immunology and Microbiology
- General Biochemistry
- Genetics and Molecular Biology
- General Medicine
- General Neuroscience
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.7554/eLife.26163
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: eLife
publication_identifier:
issn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Structural dynamics of RbmA governs plasticity of Vibrio cholerae biofilms
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2017'
...
---
_id: '15155'
abstract:
- lang: eng
text: The C-terminal transactivation domain (TAD) of BMAL1 (brain and muscle ARNT-like
1) is a regulatory hub for transcriptional coactivators and repressors that compete
for binding and, consequently, contributes to period determination of the mammalian
circadian clock. Here, we report the discovery of two distinct conformational
states that slowly exchange within the dynamic TAD to control timing. This binary
switch results from cis/trans isomerization about a highly conserved Trp-Pro imide
bond in a region of the TAD that is required for normal circadian timekeeping.
Both cis and trans isomers interact with transcriptional regulators, suggesting
that isomerization could serve a role in assembling regulatory complexes in vivo.
Toward this end, we show that locking the switch into the trans isomer leads to
shortened circadian periods. Furthermore, isomerization is regulated by the cyclophilin
family of peptidyl-prolyl isomerases, highlighting the potential for regulation
of BMAL1 protein dynamics in period determination.
article_processing_charge: No
article_type: original
author:
- first_name: Chelsea L.
full_name: Gustafson, Chelsea L.
last_name: Gustafson
- first_name: Nicole C.
full_name: Parsley, Nicole C.
last_name: Parsley
- first_name: Hande
full_name: Asimgil, Hande
last_name: Asimgil
- first_name: Hsiau-Wei
full_name: Lee, Hsiau-Wei
last_name: Lee
- first_name: Christopher
full_name: Ahlbach, Christopher
last_name: Ahlbach
- first_name: Alicia Kathleen
full_name: Michael, Alicia Kathleen
id: 6437c950-2a03-11ee-914d-d6476dd7b75c
last_name: Michael
- first_name: Haiyan
full_name: Xu, Haiyan
last_name: Xu
- first_name: Owen L.
full_name: Williams, Owen L.
last_name: Williams
- first_name: Tara L.
full_name: Davis, Tara L.
last_name: Davis
- first_name: Andrew C.
full_name: Liu, Andrew C.
last_name: Liu
- first_name: Carrie L.
full_name: Partch, Carrie L.
last_name: Partch
citation:
ama: Gustafson CL, Parsley NC, Asimgil H, et al. A slow conformational switch in
the BMAL1 transactivation domain modulates circadian rhythms. Molecular Cell.
2017;66(4):447-457.e7. doi:10.1016/j.molcel.2017.04.011
apa: Gustafson, C. L., Parsley, N. C., Asimgil, H., Lee, H.-W., Ahlbach, C., Michael,
A. K., … Partch, C. L. (2017). A slow conformational switch in the BMAL1 transactivation
domain modulates circadian rhythms. Molecular Cell. Elsevier. https://doi.org/10.1016/j.molcel.2017.04.011
chicago: Gustafson, Chelsea L., Nicole C. Parsley, Hande Asimgil, Hsiau-Wei Lee,
Christopher Ahlbach, Alicia K. Michael, Haiyan Xu, et al. “A Slow Conformational
Switch in the BMAL1 Transactivation Domain Modulates Circadian Rhythms.” Molecular
Cell. Elsevier, 2017. https://doi.org/10.1016/j.molcel.2017.04.011.
ieee: C. L. Gustafson et al., “A slow conformational switch in the BMAL1
transactivation domain modulates circadian rhythms,” Molecular Cell, vol.
66, no. 4. Elsevier, p. 447–457.e7, 2017.
ista: Gustafson CL, Parsley NC, Asimgil H, Lee H-W, Ahlbach C, Michael AK, Xu H,
Williams OL, Davis TL, Liu AC, Partch CL. 2017. A slow conformational switch in
the BMAL1 transactivation domain modulates circadian rhythms. Molecular Cell.
66(4), 447–457.e7.
mla: Gustafson, Chelsea L., et al. “A Slow Conformational Switch in the BMAL1 Transactivation
Domain Modulates Circadian Rhythms.” Molecular Cell, vol. 66, no. 4, Elsevier,
2017, p. 447–457.e7, doi:10.1016/j.molcel.2017.04.011.
short: C.L. Gustafson, N.C. Parsley, H. Asimgil, H.-W. Lee, C. Ahlbach, A.K. Michael,
H. Xu, O.L. Williams, T.L. Davis, A.C. Liu, C.L. Partch, Molecular Cell 66 (2017)
447–457.e7.
date_created: 2024-03-21T07:56:01Z
date_published: 2017-05-18T00:00:00Z
date_updated: 2024-03-25T12:19:20Z
day: '18'
doi: 10.1016/j.molcel.2017.04.011
extern: '1'
intvolume: ' 66'
issue: '4'
keyword:
- Cell Biology
- Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.molcel.2017.04.011
month: '05'
oa: 1
oa_version: Published Version
page: 447-457.e7
publication: Molecular Cell
publication_identifier:
issn:
- 1097-2765
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: A slow conformational switch in the BMAL1 transactivation domain modulates
circadian rhythms
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 66
year: '2017'
...
---
_id: '15156'
abstract:
- lang: eng
text: Circadian clocks are ubiquitous timing systems that induce rhythms of biological
activities in synchrony with night and day. In cyanobacteria, timing is generated
by a posttranslational clock consisting of KaiA, KaiB, and KaiC proteins and a
set of output signaling proteins, SasA and CikA, which transduce this rhythm to
control gene expression. Here, we describe crystal and nuclear magnetic resonance
structures of KaiB-KaiC,KaiA-KaiB-KaiC, and CikA-KaiB complexes. They reveal how
the metamorphic properties of KaiB, a protein that adopts two distinct folds,
and the post–adenosine triphosphate hydrolysis state of KaiC create a hub around
which nighttime signaling events revolve, including inactivation of KaiA and reciprocal
regulation of the mutually antagonistic signaling proteins, SasA and CikA.
article_processing_charge: No
article_type: original
author:
- first_name: Roger
full_name: Tseng, Roger
last_name: Tseng
- first_name: Nicolette F.
full_name: Goularte, Nicolette F.
last_name: Goularte
- first_name: Archana
full_name: Chavan, Archana
last_name: Chavan
- first_name: Jansen
full_name: Luu, Jansen
last_name: Luu
- first_name: Susan E.
full_name: Cohen, Susan E.
last_name: Cohen
- first_name: Yong-Gang
full_name: Chang, Yong-Gang
last_name: Chang
- first_name: Joel
full_name: Heisler, Joel
last_name: Heisler
- first_name: Sheng
full_name: Li, Sheng
last_name: Li
- first_name: Alicia Kathleen
full_name: Michael, Alicia Kathleen
id: 6437c950-2a03-11ee-914d-d6476dd7b75c
last_name: Michael
- first_name: Sarvind
full_name: Tripathi, Sarvind
last_name: Tripathi
- first_name: Susan S.
full_name: Golden, Susan S.
last_name: Golden
- first_name: Andy
full_name: LiWang, Andy
last_name: LiWang
- first_name: Carrie L.
full_name: Partch, Carrie L.
last_name: Partch
citation:
ama: Tseng R, Goularte NF, Chavan A, et al. Structural basis of the day-night transition
in a bacterial circadian clock. Science. 2017;355(6330):1174-1180. doi:10.1126/science.aag2516
apa: Tseng, R., Goularte, N. F., Chavan, A., Luu, J., Cohen, S. E., Chang, Y.-G.,
… Partch, C. L. (2017). Structural basis of the day-night transition in a bacterial
circadian clock. Science. American Association for the Advancement of Science.
https://doi.org/10.1126/science.aag2516
chicago: Tseng, Roger, Nicolette F. Goularte, Archana Chavan, Jansen Luu, Susan
E. Cohen, Yong-Gang Chang, Joel Heisler, et al. “Structural Basis of the Day-Night
Transition in a Bacterial Circadian Clock.” Science. American Association
for the Advancement of Science, 2017. https://doi.org/10.1126/science.aag2516.
ieee: R. Tseng et al., “Structural basis of the day-night transition in a
bacterial circadian clock,” Science, vol. 355, no. 6330. American Association
for the Advancement of Science, pp. 1174–1180, 2017.
ista: Tseng R, Goularte NF, Chavan A, Luu J, Cohen SE, Chang Y-G, Heisler J, Li
S, Michael AK, Tripathi S, Golden SS, LiWang A, Partch CL. 2017. Structural basis
of the day-night transition in a bacterial circadian clock. Science. 355(6330),
1174–1180.
mla: Tseng, Roger, et al. “Structural Basis of the Day-Night Transition in a Bacterial
Circadian Clock.” Science, vol. 355, no. 6330, American Association for
the Advancement of Science, 2017, pp. 1174–80, doi:10.1126/science.aag2516.
short: R. Tseng, N.F. Goularte, A. Chavan, J. Luu, S.E. Cohen, Y.-G. Chang, J. Heisler,
S. Li, A.K. Michael, S. Tripathi, S.S. Golden, A. LiWang, C.L. Partch, Science
355 (2017) 1174–1180.
date_created: 2024-03-21T07:56:24Z
date_published: 2017-03-17T00:00:00Z
date_updated: 2024-03-25T12:16:44Z
day: '17'
doi: 10.1126/science.aag2516
extern: '1'
intvolume: ' 355'
issue: '6330'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '03'
oa_version: None
page: 1174-1180
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Structural basis of the day-night transition in a bacterial circadian clock
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 355
year: '2017'
...
---
_id: '15157'
abstract:
- lang: eng
text: The basic helix–loop–helix PAS domain (bHLH-PAS) transcription factor CLOCK:BMAL1
(brain and muscle Arnt-like protein 1) sits at the core of the mammalian circadian
transcription/translation feedback loop. Precise control of CLOCK:BMAL1 activity
by coactivators and repressors establishes the ∼24-h periodicity of gene expression.
Formation of a repressive complex, defined by the core clock proteins cryptochrome
1 (CRY1):CLOCK:BMAL1, plays an important role controlling the switch from repression
to activation each day. Here we show that CRY1 binds directly to the PAS domain
core of CLOCK:BMAL1, driven primarily by interaction with the CLOCK PAS-B domain.
Integrative modeling and solution X-ray scattering studies unambiguously position
a key loop of the CLOCK PAS-B domain in the secondary pocket of CRY1, analogous
to the antenna chromophore-binding pocket of photolyase. CRY1 docks onto the transcription
factor alongside the PAS domains, extending above the DNA-binding bHLH domain.
Single point mutations at the interface on either CRY1 or CLOCK disrupt formation
of the ternary complex, highlighting the importance of this interface for direct
regulation of CLOCK:BMAL1 activity by CRY1.
article_processing_charge: No
article_type: original
author:
- first_name: Alicia Kathleen
full_name: Michael, Alicia Kathleen
id: 6437c950-2a03-11ee-914d-d6476dd7b75c
last_name: Michael
- first_name: Jennifer L.
full_name: Fribourgh, Jennifer L.
last_name: Fribourgh
- first_name: Yogarany
full_name: Chelliah, Yogarany
last_name: Chelliah
- first_name: Colby R.
full_name: Sandate, Colby R.
last_name: Sandate
- first_name: Greg L.
full_name: Hura, Greg L.
last_name: Hura
- first_name: Dina
full_name: Schneidman-Duhovny, Dina
last_name: Schneidman-Duhovny
- first_name: Sarvind M.
full_name: Tripathi, Sarvind M.
last_name: Tripathi
- first_name: Joseph S.
full_name: Takahashi, Joseph S.
last_name: Takahashi
- first_name: Carrie L.
full_name: Partch, Carrie L.
last_name: Partch
citation:
ama: Michael AK, Fribourgh JL, Chelliah Y, et al. Formation of a repressive complex
in the mammalian circadian clock is mediated by the secondary pocket of CRY1.
Proceedings of the National Academy of Sciences. 2017;114(7):1560-1565.
doi:10.1073/pnas.1615310114
apa: Michael, A. K., Fribourgh, J. L., Chelliah, Y., Sandate, C. R., Hura, G. L.,
Schneidman-Duhovny, D., … Partch, C. L. (2017). Formation of a repressive complex
in the mammalian circadian clock is mediated by the secondary pocket of CRY1.
Proceedings of the National Academy of Sciences. Proceedings of the National
Academy of Sciences. https://doi.org/10.1073/pnas.1615310114
chicago: Michael, Alicia K., Jennifer L. Fribourgh, Yogarany Chelliah, Colby R.
Sandate, Greg L. Hura, Dina Schneidman-Duhovny, Sarvind M. Tripathi, Joseph S.
Takahashi, and Carrie L. Partch. “Formation of a Repressive Complex in the Mammalian
Circadian Clock Is Mediated by the Secondary Pocket of CRY1.” Proceedings of
the National Academy of Sciences. Proceedings of the National Academy of Sciences,
2017. https://doi.org/10.1073/pnas.1615310114.
ieee: A. K. Michael et al., “Formation of a repressive complex in the mammalian
circadian clock is mediated by the secondary pocket of CRY1,” Proceedings of
the National Academy of Sciences, vol. 114, no. 7. Proceedings of the National
Academy of Sciences, pp. 1560–1565, 2017.
ista: Michael AK, Fribourgh JL, Chelliah Y, Sandate CR, Hura GL, Schneidman-Duhovny
D, Tripathi SM, Takahashi JS, Partch CL. 2017. Formation of a repressive complex
in the mammalian circadian clock is mediated by the secondary pocket of CRY1.
Proceedings of the National Academy of Sciences. 114(7), 1560–1565.
mla: Michael, Alicia K., et al. “Formation of a Repressive Complex in the Mammalian
Circadian Clock Is Mediated by the Secondary Pocket of CRY1.” Proceedings of
the National Academy of Sciences, vol. 114, no. 7, Proceedings of the National
Academy of Sciences, 2017, pp. 1560–65, doi:10.1073/pnas.1615310114.
short: A.K. Michael, J.L. Fribourgh, Y. Chelliah, C.R. Sandate, G.L. Hura, D. Schneidman-Duhovny,
S.M. Tripathi, J.S. Takahashi, C.L. Partch, Proceedings of the National Academy
of Sciences 114 (2017) 1560–1565.
date_created: 2024-03-21T07:56:50Z
date_published: 2017-01-31T00:00:00Z
date_updated: 2024-03-25T12:12:23Z
day: '31'
doi: 10.1073/pnas.1615310114
extern: '1'
external_id:
pmid:
- '28143926'
intvolume: ' 114'
issue: '7'
keyword:
- Multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1073/pnas.1615310114
month: '01'
oa: 1
oa_version: Published Version
page: 1560-1565
pmid: 1
publication: Proceedings of the National Academy of Sciences
publication_identifier:
eissn:
- 1091-6490
issn:
- 0027-8424
publication_status: published
publisher: Proceedings of the National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Formation of a repressive complex in the mammalian circadian clock is mediated
by the secondary pocket of CRY1
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 114
year: '2017'
...
---
_id: '15158'
abstract:
- lang: eng
text: 'Cryptochromes are evolutionarily related to the light‐dependent DNA repair
enzyme photolyase, serving as major regulators of circadian rhythms in insects
and vertebrate animals. There are two types of cryptochromes in the animal kingdom:
Drosophila‐like CRYs that act as nonvisual photopigments
linking circadian rhythms to the environmental light/dark cycle, and vertebrate‐like
CRYs that do not appear to sense light directly, but control the generation of
circadian rhythms by acting as transcriptional repressors. Some animals have both
types of CRYs, while others possess only one. Cryptochromes have two domains,
the photolyase homology region (PHR) and an extended, intrinsically disordered
C‐terminus. While all animal CRYs share a high degree of sequence and structural
homology in their PHR domains, the C‐termini are divergent in both length and
sequence identity. Recently, cryptochrome function has been shown to extend beyond
its pivotal role in circadian clocks, participating in regulation of the DNA damage
response, cancer progression and glucocorticoid signaling, as well as being implicated
as possible magnetoreceptors. In this review, we provide a historical perspective
on the discovery of animal cryptochromes, examine similarities and differences
of the two types of animal cryptochromes and explore some of the divergent roles
for this class of proteins.'
article_processing_charge: No
article_type: original
author:
- first_name: Alicia Kathleen
full_name: Michael, Alicia Kathleen
id: 6437c950-2a03-11ee-914d-d6476dd7b75c
last_name: Michael
- first_name: Jennifer L.
full_name: Fribourgh, Jennifer L.
last_name: Fribourgh
- first_name: Russell N.
full_name: Van Gelder, Russell N.
last_name: Van Gelder
- first_name: Carrie L.
full_name: Partch, Carrie L.
last_name: Partch
citation:
ama: 'Michael AK, Fribourgh JL, Van Gelder RN, Partch CL. Animal cryptochromes:
Divergent roles in light perception, circadian timekeeping and beyond. Photochemistry
and Photobiology. 2017;93(1):128-140. doi:10.1111/php.12677'
apa: 'Michael, A. K., Fribourgh, J. L., Van Gelder, R. N., & Partch, C. L. (2017).
Animal cryptochromes: Divergent roles in light perception, circadian timekeeping
and beyond. Photochemistry and Photobiology. Wiley. https://doi.org/10.1111/php.12677'
chicago: 'Michael, Alicia K., Jennifer L. Fribourgh, Russell N. Van Gelder, and
Carrie L. Partch. “Animal Cryptochromes: Divergent Roles in Light Perception,
Circadian Timekeeping and Beyond.” Photochemistry and Photobiology. Wiley,
2017. https://doi.org/10.1111/php.12677.'
ieee: 'A. K. Michael, J. L. Fribourgh, R. N. Van Gelder, and C. L. Partch, “Animal
cryptochromes: Divergent roles in light perception, circadian timekeeping and
beyond,” Photochemistry and Photobiology, vol. 93, no. 1. Wiley, pp. 128–140,
2017.'
ista: 'Michael AK, Fribourgh JL, Van Gelder RN, Partch CL. 2017. Animal cryptochromes:
Divergent roles in light perception, circadian timekeeping and beyond. Photochemistry
and Photobiology. 93(1), 128–140.'
mla: 'Michael, Alicia K., et al. “Animal Cryptochromes: Divergent Roles in Light
Perception, Circadian Timekeeping and Beyond.” Photochemistry and Photobiology,
vol. 93, no. 1, Wiley, 2017, pp. 128–40, doi:10.1111/php.12677.'
short: A.K. Michael, J.L. Fribourgh, R.N. Van Gelder, C.L. Partch, Photochemistry
and Photobiology 93 (2017) 128–140.
date_created: 2024-03-21T07:57:18Z
date_published: 2017-02-01T00:00:00Z
date_updated: 2024-03-25T12:09:21Z
day: '01'
doi: 10.1111/php.12677
extern: '1'
intvolume: ' 93'
issue: '1'
keyword:
- Physical and Theoretical Chemistry
- General Medicine
- Biochemistry
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1111/php.12677
month: '02'
oa: 1
oa_version: Published Version
page: 128-140
publication: Photochemistry and Photobiology
publication_identifier:
eissn:
- 1751-1097
issn:
- 0031-8655
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Animal cryptochromes: Divergent roles in light perception, circadian timekeeping
and beyond'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 93
year: '2017'
...
---
_id: '15239'
abstract:
- lang: eng
text: Using images from the Hubble Space Telescope Advanced Camera for Surveys,
we measure the rate of cooling of white dwarfs in the globular cluster 47 Tucanae
and compare it to modelled cooling curves. We examine the effects of the outer
convective envelope reaching the nearly isothermal degenerate core and the release
of latent heat during core crystallization on the white dwarf cooling rates. For
white dwarfs typical of 47 Tuc, the onset of these effects occur at similar times.
The latent heat released during crystallization is a small heat source. In contrast,
the heat reservoir of the degenerate core is substantially larger. When the convective
envelope reaches the nearly isothermal interior of the white dwarf, the star becomes
brighter than it would be in the absence of this effect. Our modelled cooling
curves that include this convective coupling closely match the observed luminosity
function of the white dwarfs in 47 Tuc.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Alysa
full_name: Obertas, Alysa
last_name: Obertas
- first_name: Ilaria
full_name: Caiazzo, Ilaria
id: 8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d
last_name: Caiazzo
orcid: 0000-0002-4770-5388
- first_name: Jeremy
full_name: Heyl, Jeremy
last_name: Heyl
- first_name: Harvey
full_name: Richer, Harvey
last_name: Richer
- first_name: Jason
full_name: Kalirai, Jason
last_name: Kalirai
- first_name: Pier-Emmanuel
full_name: Tremblay, Pier-Emmanuel
last_name: Tremblay
citation:
ama: Obertas A, Caiazzo I, Heyl J, Richer H, Kalirai J, Tremblay P-E. The onset
of convective coupling and freezing in the white dwarfs of 47 Tucanae. Monthly
Notices of the Royal Astronomical Society. 2017;474(1):677-682. doi:10.1093/mnras/stx2759
apa: Obertas, A., Caiazzo, I., Heyl, J., Richer, H., Kalirai, J., & Tremblay,
P.-E. (2017). The onset of convective coupling and freezing in the white dwarfs
of 47 Tucanae. Monthly Notices of the Royal Astronomical Society. Oxford
University Press. https://doi.org/10.1093/mnras/stx2759
chicago: Obertas, Alysa, Ilaria Caiazzo, Jeremy Heyl, Harvey Richer, Jason Kalirai,
and Pier-Emmanuel Tremblay. “The Onset of Convective Coupling and Freezing in
the White Dwarfs of 47 Tucanae.” Monthly Notices of the Royal Astronomical
Society. Oxford University Press, 2017. https://doi.org/10.1093/mnras/stx2759.
ieee: A. Obertas, I. Caiazzo, J. Heyl, H. Richer, J. Kalirai, and P.-E. Tremblay,
“The onset of convective coupling and freezing in the white dwarfs of 47 Tucanae,”
Monthly Notices of the Royal Astronomical Society, vol. 474, no. 1. Oxford
University Press, pp. 677–682, 2017.
ista: Obertas A, Caiazzo I, Heyl J, Richer H, Kalirai J, Tremblay P-E. 2017. The
onset of convective coupling and freezing in the white dwarfs of 47 Tucanae. Monthly
Notices of the Royal Astronomical Society. 474(1), 677–682.
mla: Obertas, Alysa, et al. “The Onset of Convective Coupling and Freezing in the
White Dwarfs of 47 Tucanae.” Monthly Notices of the Royal Astronomical Society,
vol. 474, no. 1, Oxford University Press, 2017, pp. 677–82, doi:10.1093/mnras/stx2759.
short: A. Obertas, I. Caiazzo, J. Heyl, H. Richer, J. Kalirai, P.-E. Tremblay, Monthly
Notices of the Royal Astronomical Society 474 (2017) 677–682.
date_created: 2024-03-26T10:40:05Z
date_published: 2017-10-24T00:00:00Z
date_updated: 2024-04-08T07:04:10Z
day: '24'
doi: 10.1093/mnras/stx2759
extern: '1'
external_id:
arxiv:
- '1709.08097'
intvolume: ' 474'
issue: '1'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.1709.08097
month: '10'
oa: 1
oa_version: Preprint
page: 677-682
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: The onset of convective coupling and freezing in the white dwarfs of 47 Tucanae
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 474
year: '2017'
...
---
_id: '15240'
abstract:
- lang: eng
text: "Multi-epoch observations with the Advanced Camera Survey and WFC3 on the
Hubble Space Telescope provide a unique and comprehensive probe of stellar dynamics
within 47 Tucanae. We confront analytic models of the globular cluster with the
observed stellar proper motions that probe along the main sequence from just above
0.8–0.1M⊙ as well as white dwarfs younger than 1 Gyr. One field lies just beyond
the half-light radius where dynamical models (e.g., lowered Maxwellian distributions)
make robust predictions for the stellar proper motions. The observed proper motions
in this outer field show evidence for anisotropy in the velocity distribution
as well as skewness; the latter is evidence of rotation. The measured velocity
dispersions and surface brightness distributions agree in detail with a rotating
anisotropic model of the stellar distribution function with mild dependence of
the proper-motion dispersion on mass. However, the best-fitting models underpredict
the rotation and skewness of the stellar velocities. In the second field, centered
on the core of the cluster, the mass segregation in proper motion is much stronger.
Nevertheless the model developed in the outer field can be extended inward by
taking this mass segregation into account in a heuristic fashion. The proper motions
of the main-sequence stars yield a mass estimate of the cluster of \r\n at a distance
of 4.7 kpc. By comparing the proper motions of a sample of giant and subgiant
stars with the observed radial velocities we estimate the distance to the cluster
kinematically to be 4.29 ± 0.47 kpc."
article_number: '186'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: J.
full_name: Heyl, J.
last_name: Heyl
- first_name: Ilaria
full_name: Caiazzo, Ilaria
id: 8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d
last_name: Caiazzo
orcid: 0000-0002-4770-5388
- first_name: H.
full_name: Richer, H.
last_name: Richer
- first_name: J.
full_name: Anderson, J.
last_name: Anderson
- first_name: J.
full_name: Kalirai, J.
last_name: Kalirai
- first_name: J.
full_name: Parada, J.
last_name: Parada
citation:
ama: 'Heyl J, Caiazzo I, Richer H, Anderson J, Kalirai J, Parada J. Deep HST imaging
in 47 Tucanae: A global dynamical model. The Astrophysical Journal. 2017;850(2).
doi:10.3847/1538-4357/aa974f'
apa: 'Heyl, J., Caiazzo, I., Richer, H., Anderson, J., Kalirai, J., & Parada,
J. (2017). Deep HST imaging in 47 Tucanae: A global dynamical model. The Astrophysical
Journal. American Astronomical Society. https://doi.org/10.3847/1538-4357/aa974f'
chicago: 'Heyl, J., Ilaria Caiazzo, H. Richer, J. Anderson, J. Kalirai, and J. Parada.
“Deep HST Imaging in 47 Tucanae: A Global Dynamical Model.” The Astrophysical
Journal. American Astronomical Society, 2017. https://doi.org/10.3847/1538-4357/aa974f.'
ieee: 'J. Heyl, I. Caiazzo, H. Richer, J. Anderson, J. Kalirai, and J. Parada, “Deep
HST imaging in 47 Tucanae: A global dynamical model,” The Astrophysical Journal,
vol. 850, no. 2. American Astronomical Society, 2017.'
ista: 'Heyl J, Caiazzo I, Richer H, Anderson J, Kalirai J, Parada J. 2017. Deep
HST imaging in 47 Tucanae: A global dynamical model. The Astrophysical Journal.
850(2), 186.'
mla: 'Heyl, J., et al. “Deep HST Imaging in 47 Tucanae: A Global Dynamical Model.”
The Astrophysical Journal, vol. 850, no. 2, 186, American Astronomical
Society, 2017, doi:10.3847/1538-4357/aa974f.'
short: J. Heyl, I. Caiazzo, H. Richer, J. Anderson, J. Kalirai, J. Parada, The Astrophysical
Journal 850 (2017).
date_created: 2024-03-26T10:40:23Z
date_published: 2017-12-01T00:00:00Z
date_updated: 2024-04-08T07:04:35Z
day: '01'
doi: 10.3847/1538-4357/aa974f
extern: '1'
external_id:
arxiv:
- '1710.10666'
intvolume: ' 850'
issue: '2'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.1710.10666
month: '12'
oa: 1
oa_version: Preprint
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: American Astronomical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Deep HST imaging in 47 Tucanae: A global dynamical model'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 850
year: '2017'
...
---
_id: '15241'
abstract:
- lang: eng
text: We present a model to account for the observed debris discs around young white
dwarfs and the presence of metal lines in their spectra. Stellar evolution models
predict that the mass-loss on the AGB will be pulsed; furthermore, observations
indicate that the bulk of the mass-loss occurs on the AGB. In this case, if the
progenitors of the white dwarfs had remnants of planetary formation like the Sun’s
Oort cloud or the Kuiper Belt and a planet lying within that cloud or nearby,
we find that up to 2 per cent of the planetesimals will fall either into planet-crossing
orbits or into chaotic regions after the mass-loss, depending on the location
and mass of the planet (from Mars to Neptune). This yields a sufficient mass of
comets that can be scattered towards the star, form a debris disc and pollute
the atmosphere.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Ilaria
full_name: Caiazzo, Ilaria
id: 8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d
last_name: Caiazzo
orcid: 0000-0002-4770-5388
- first_name: Jeremy S.
full_name: Heyl, Jeremy S.
last_name: Heyl
citation:
ama: Caiazzo I, Heyl JS. Polluting white dwarfs with perturbed exo-comets. Monthly
Notices of the Royal Astronomical Society. 2017;469(3):2750-2759. doi:10.1093/mnras/stx1036
apa: Caiazzo, I., & Heyl, J. S. (2017). Polluting white dwarfs with perturbed
exo-comets. Monthly Notices of the Royal Astronomical Society. Oxford University
Press. https://doi.org/10.1093/mnras/stx1036
chicago: Caiazzo, Ilaria, and Jeremy S. Heyl. “Polluting White Dwarfs with Perturbed
Exo-Comets.” Monthly Notices of the Royal Astronomical Society. Oxford
University Press, 2017. https://doi.org/10.1093/mnras/stx1036.
ieee: I. Caiazzo and J. S. Heyl, “Polluting white dwarfs with perturbed exo-comets,”
Monthly Notices of the Royal Astronomical Society, vol. 469, no. 3. Oxford
University Press, pp. 2750–2759, 2017.
ista: Caiazzo I, Heyl JS. 2017. Polluting white dwarfs with perturbed exo-comets.
Monthly Notices of the Royal Astronomical Society. 469(3), 2750–2759.
mla: Caiazzo, Ilaria, and Jeremy S. Heyl. “Polluting White Dwarfs with Perturbed
Exo-Comets.” Monthly Notices of the Royal Astronomical Society, vol. 469,
no. 3, Oxford University Press, 2017, pp. 2750–59, doi:10.1093/mnras/stx1036.
short: I. Caiazzo, J.S. Heyl, Monthly Notices of the Royal Astronomical Society
469 (2017) 2750–2759.
date_created: 2024-03-26T10:40:45Z
date_published: 2017-05-01T00:00:00Z
date_updated: 2024-10-14T12:33:43Z
day: '01'
doi: 10.1093/mnras/stx1036
extern: '1'
external_id:
arxiv:
- '1702.07682'
intvolume: ' 469'
issue: '3'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.1702.07682
month: '05'
oa: 1
oa_version: Preprint
page: 2750-2759
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Polluting white dwarfs with perturbed exo-comets
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 469
year: '2017'
...
---
_id: '15243'
abstract:
- lang: eng
text: High-energy (>250 keV) emission has been detected persisting for several tens
of seconds after the initial spike of magnetar giant flares (GFs). It has been
conjectured that this emission might arise via inverse Compton scattering in a
highly extended corona generated by super-Eddington outflows high up in the magnetosphere.
In this paper, we undertake a detailed examination of this model. We investigate
the properties of the required scatterers, and whether the mechanism is consistent
with the degree of pulsed emission observed in the tail of the GF. We conclude
that the mechanism is consistent with current data, although the origin of the
scattering population remains an open question. We propose an alternative picture
in which the emission is closer to that star and is dominated by synchrotron radiation.
The Reuven Ramaty High Energy Solar Spectroscopic Imager observations of the 2004
December flare modestly favour this latter picture. We assess the prospects for
the Fermi Gamma-ray Space Telescope to detect and characterize a similar high-energy
component in a future GF. Such a detection should help to resolve some of the
outstanding issues.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: C.
full_name: Elenbaas, C.
last_name: Elenbaas
- first_name: D.
full_name: Huppenkothen, D.
last_name: Huppenkothen
- first_name: C.
full_name: Omand, C.
last_name: Omand
- first_name: A. L.
full_name: Watts, A. L.
last_name: Watts
- first_name: E.
full_name: Bissaldi, E.
last_name: Bissaldi
- first_name: Ilaria
full_name: Caiazzo, Ilaria
id: 8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d
last_name: Caiazzo
orcid: 0000-0002-4770-5388
- first_name: J.
full_name: Heyl, J.
last_name: Heyl
citation:
ama: Elenbaas C, Huppenkothen D, Omand C, et al. Magnetar giant flare high-energy
emission. Monthly Notices of the Royal Astronomical Society. 2017;471(2):1856-1872.
doi:10.1093/mnras/stx1727
apa: Elenbaas, C., Huppenkothen, D., Omand, C., Watts, A. L., Bissaldi, E., Caiazzo,
I., & Heyl, J. (2017). Magnetar giant flare high-energy emission. Monthly
Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/stx1727
chicago: Elenbaas, C., D. Huppenkothen, C. Omand, A. L. Watts, E. Bissaldi, Ilaria
Caiazzo, and J. Heyl. “Magnetar Giant Flare High-Energy Emission.” Monthly
Notices of the Royal Astronomical Society. Oxford University Press, 2017.
https://doi.org/10.1093/mnras/stx1727.
ieee: C. Elenbaas et al., “Magnetar giant flare high-energy emission,” Monthly
Notices of the Royal Astronomical Society, vol. 471, no. 2. Oxford University
Press, pp. 1856–1872, 2017.
ista: Elenbaas C, Huppenkothen D, Omand C, Watts AL, Bissaldi E, Caiazzo I, Heyl
J. 2017. Magnetar giant flare high-energy emission. Monthly Notices of the Royal
Astronomical Society. 471(2), 1856–1872.
mla: Elenbaas, C., et al. “Magnetar Giant Flare High-Energy Emission.” Monthly
Notices of the Royal Astronomical Society, vol. 471, no. 2, Oxford University
Press, 2017, pp. 1856–72, doi:10.1093/mnras/stx1727.
short: C. Elenbaas, D. Huppenkothen, C. Omand, A.L. Watts, E. Bissaldi, I. Caiazzo,
J. Heyl, Monthly Notices of the Royal Astronomical Society 471 (2017) 1856–1872.
date_created: 2024-03-26T10:41:24Z
date_published: 2017-07-13T00:00:00Z
date_updated: 2024-04-08T07:05:47Z
day: '13'
doi: 10.1093/mnras/stx1727
extern: '1'
external_id:
arxiv:
- '1707.02922'
intvolume: ' 471'
issue: '2'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.1707.02922
month: '07'
oa: 1
oa_version: Preprint
page: 1856-1872
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Magnetar giant flare high-energy emission
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 471
year: '2017'
...
---
_id: '1061'
abstract:
- lang: eng
text: 'Background: Metabolic engineering and synthetic biology of cyanobacteria
offer a promising sustainable alternative approach for fossil-based ethylene production,
by using sunlight via oxygenic photosynthesis, to convert carbon dioxide directly
into ethylene. Towards this, both well-studied cyanobacteria, i.e., Synechocystis
sp PCC 6803 and Synechococcus elongatus PCC 7942, have been engineered to produce
ethylene by introducing the ethylene-forming enzyme (Efe) from Pseudomonas syringae
pv. phaseolicola PK2 (the Kudzu strain), which catalyzes the conversion of the
ubiquitous tricarboxylic acid cycle intermediate 2-oxoglutarate into ethylene.
Results: This study focuses on Synechocystis sp PCC 6803 and shows stable ethylene
production through the integration of a codon-optimized version of the efe gene
under control of the Ptrc promoter and the core Shine-Dalgarno sequence (5\''-AGGAGG-3\'')
as the ribosome-binding site (RBS), at the slr0168 neutral site. We have increased
ethylene production twofold by RBS screening and further investigated improving
ethylene production from a single gene copy of efe, using multiple tandem promoters
and by putting our best construct on an RSF1010-based broad-host-self-replicating
plasmid, which has a higher copy number than the genome. Moreover, to raise the
intracellular amounts of the key Efe substrate, 2-oxoglutarate, from which ethylene
is formed, we constructed a glycogen-synthesis knockout mutant (glgC) and introduced
the ethylene biosynthetic pathway in it. Under nitrogen limiting conditions, the
glycogen knockout strain has increased intracellular 2-oxoglutarate levels; however,
surprisingly, ethylene production was lower in this strain than in the wild-type
background. Conclusion: Making use of different RBS sequences, production of ethylene
ranging over a 20-fold difference has been achieved. However, a further increase
of production through multiple tandem promoters and a broad-host plasmid was not
achieved speculating that the transcription strength and the gene copy number
are not the limiting factors in our system.'
article_number: '34'
article_processing_charge: No
author:
- first_name: Vinod
full_name: Veetil, Vinod
last_name: Veetil
- first_name: Andreas
full_name: Angermayr, Andreas
id: 4677C796-F248-11E8-B48F-1D18A9856A87
last_name: Angermayr
orcid: 0000-0001-8619-2223
- first_name: Klaas
full_name: Hellingwerf, Klaas
last_name: Hellingwerf
citation:
ama: Veetil V, Angermayr A, Hellingwerf K. Ethylene production with engineered Synechocystis
sp PCC 6803 strains. Microbial Cell Factories. 2017;16(1). doi:10.1186/s12934-017-0645-5
apa: Veetil, V., Angermayr, A., & Hellingwerf, K. (2017). Ethylene production
with engineered Synechocystis sp PCC 6803 strains. Microbial Cell Factories.
BioMed Central. https://doi.org/10.1186/s12934-017-0645-5
chicago: Veetil, Vinod, Andreas Angermayr, and Klaas Hellingwerf. “Ethylene Production
with Engineered Synechocystis Sp PCC 6803 Strains.” Microbial Cell Factories.
BioMed Central, 2017. https://doi.org/10.1186/s12934-017-0645-5.
ieee: V. Veetil, A. Angermayr, and K. Hellingwerf, “Ethylene production with engineered
Synechocystis sp PCC 6803 strains,” Microbial Cell Factories, vol. 16,
no. 1. BioMed Central, 2017.
ista: Veetil V, Angermayr A, Hellingwerf K. 2017. Ethylene production with engineered
Synechocystis sp PCC 6803 strains. Microbial Cell Factories. 16(1), 34.
mla: Veetil, Vinod, et al. “Ethylene Production with Engineered Synechocystis Sp
PCC 6803 Strains.” Microbial Cell Factories, vol. 16, no. 1, 34, BioMed
Central, 2017, doi:10.1186/s12934-017-0645-5.
short: V. Veetil, A. Angermayr, K. Hellingwerf, Microbial Cell Factories 16 (2017).
date_created: 2018-12-11T11:49:56Z
date_published: 2017-02-23T00:00:00Z
date_updated: 2023-09-20T12:09:21Z
day: '23'
ddc:
- '579'
doi: 10.1186/s12934-017-0645-5
extern: '1'
external_id:
isi:
- '000397733000001'
pmid:
- '28231787'
file:
- access_level: open_access
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:16:50Z
date_updated: 2018-12-12T10:16:50Z
file_id: '5240'
file_name: IST-2017-792-v1+1_s12934-017-0645-5.pdf
file_size: 1361313
relation: main_file
file_date_updated: 2018-12-12T10:16:50Z
has_accepted_license: '1'
intvolume: ' 16'
isi: 1
issue: '1'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: Microbial Cell Factories
publication_identifier:
issn:
- '14752859'
publication_status: published
publisher: BioMed Central
publist_id: '6325'
pubrep_id: '792'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Ethylene production with engineered Synechocystis sp PCC 6803 strains
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 16
year: '2017'
...
---
_id: '1062'
abstract:
- lang: eng
text: Mouse chromaffin cells (MCCs) generate action potential (AP) firing that regulates
the Ca2+‐dependent release of catecholamines (CAs). Recent findings indicate that
MCCs possess a variety of spontaneous firing modes that span from the common ‘tonic‐irregular’
to the less frequent ‘burst’ firing. This latter is evident in a small fraction
of MCCs but occurs regularly when Nav1.3/1.7 channels are made less available
or when the Slo1β2‐subunit responsible for BK channel inactivation is deleted.
Burst firing causes large increases of Ca2+‐entry and potentiates CA release by
∼3.5‐fold and thus may be a key mechanism for regulating MCC function. With the
aim to uncover a physiological role for burst‐firing we investigated the effects
of acidosis on MCC activity. Lowering the extracellular pH (pHo) from 7.4 to 7.0
and 6.6 induces cell depolarizations of 10–15 mV that generate repeated bursts.
Bursts at pHo 6.6 lasted ∼330 ms, occurred at 1–2 Hz and caused an ∼7‐fold increase
of CA cumulative release. Burst firing originates from the inhibition of the pH‐sensitive
TASK‐1/TASK‐3 channels and from a 40% BK channel conductance reduction at pHo
7.0. The same pHo had little or no effect on Nav, Cav, Kv and SK channels that
support AP firing in MCCs. Burst firing of pHo 6.6 could be mimicked by mixtures
of the TASK‐1 blocker A1899 (300 nm) and BK blocker paxilline (300 nm) and could
be prevented by blocking L‐type channels by adding 3 μm nifedipine. Mixtures of
the two blockers raised cumulative CA‐secretion even more than low pHo (∼12‐fold),
showing that the action of protons on vesicle release is mainly a result of the
ionic conductance changes that increase Ca2+‐entry during bursts. Our data provide
direct evidence suggesting that MCCs respond to low pHo with sustained depolarization,
burst firing and enhanced CA‐secretion, thus mimicking the physiological response
of CCs to acute acidosis and hyperkalaemia generated during heavy exercise and
muscle fatigue.
article_processing_charge: No
author:
- first_name: Laura
full_name: Guarina, Laura
last_name: Guarina
- first_name: David H
full_name: Vandael, David H
id: 3AE48E0A-F248-11E8-B48F-1D18A9856A87
last_name: Vandael
orcid: 0000-0001-7577-1676
- first_name: Valentina
full_name: Carabelli, Valentina
last_name: Carabelli
- first_name: Emilio
full_name: Carbone, Emilio
last_name: Carbone
citation:
ama: Guarina L, Vandael DH, Carabelli V, Carbone E. Low pH inf o boosts burst firing
and catecholamine release by blocking TASK-1 and BK channels while preserving
Cav1 channels in mouse chromaffin cells. Journal of Physiology. 2017;595(8):2587-2609.
doi:10.1113/JP273735
apa: Guarina, L., Vandael, D. H., Carabelli, V., & Carbone, E. (2017). Low pH
inf o boosts burst firing and catecholamine release by blocking TASK-1 and BK
channels while preserving Cav1 channels in mouse chromaffin cells. Journal
of Physiology. Wiley-Blackwell. https://doi.org/10.1113/JP273735
chicago: Guarina, Laura, David H Vandael, Valentina Carabelli, and Emilio Carbone.
“Low PH Inf o Boosts Burst Firing and Catecholamine Release by Blocking TASK-1
and BK Channels While Preserving Cav1 Channels in Mouse Chromaffin Cells.” Journal
of Physiology. Wiley-Blackwell, 2017. https://doi.org/10.1113/JP273735.
ieee: L. Guarina, D. H. Vandael, V. Carabelli, and E. Carbone, “Low pH inf o boosts
burst firing and catecholamine release by blocking TASK-1 and BK channels while
preserving Cav1 channels in mouse chromaffin cells,” Journal of Physiology,
vol. 595, no. 8. Wiley-Blackwell, pp. 2587–2609, 2017.
ista: Guarina L, Vandael DH, Carabelli V, Carbone E. 2017. Low pH inf o boosts burst
firing and catecholamine release by blocking TASK-1 and BK channels while preserving
Cav1 channels in mouse chromaffin cells. Journal of Physiology. 595(8), 2587–2609.
mla: Guarina, Laura, et al. “Low PH Inf o Boosts Burst Firing and Catecholamine
Release by Blocking TASK-1 and BK Channels While Preserving Cav1 Channels in Mouse
Chromaffin Cells.” Journal of Physiology, vol. 595, no. 8, Wiley-Blackwell,
2017, pp. 2587–609, doi:10.1113/JP273735.
short: L. Guarina, D.H. Vandael, V. Carabelli, E. Carbone, Journal of Physiology
595 (2017) 2587–2609.
date_created: 2018-12-11T11:49:56Z
date_published: 2017-04-15T00:00:00Z
date_updated: 2023-09-20T12:09:47Z
day: '15'
doi: 10.1113/JP273735
extern: '1'
external_id:
isi:
- '000399430300022'
intvolume: ' 595'
isi: 1
issue: '8'
language:
- iso: eng
month: '04'
oa_version: None
page: '2587 - 2609 '
publication: Journal of Physiology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '6326'
quality_controlled: '1'
status: public
title: Low pH inf o boosts burst firing and catecholamine release by blocking TASK-1
and BK channels while preserving Cav1 channels in mouse chromaffin cells
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 595
year: '2017'
...
---
_id: '1063'
abstract:
- lang: eng
text: Severe environmental change can drive a population extinct unless the population
adapts in time to the new conditions (“evolutionary rescue”). How does biparental
sexual reproduction influence the chances of population persistence compared to
clonal reproduction or selfing? In this article, we set up a one‐locus two‐allele
model for adaptation in diploid species, where rescue is contingent on the establishment
of the mutant homozygote. Reproduction can occur by random mating, selfing, or
clonally. Random mating generates and destroys the rescue mutant; selfing is efficient
at generating it but at the same time depletes the heterozygote, which can lead
to a low mutant frequency in the standing genetic variation. Due to these (and
other) antagonistic effects, we find a nontrivial dependence of population survival
on the rate of sex/selfing, which is strongly influenced by the dominance coefficient
of the mutation before and after the environmental change. Importantly, since
mating with the wild‐type breaks the mutant homozygote up, a slow decay of the
wild‐type population size can impede rescue in randomly mating populations.
article_processing_charge: No
author:
- first_name: Hildegard
full_name: Uecker, Hildegard
id: 2DB8F68A-F248-11E8-B48F-1D18A9856A87
last_name: Uecker
orcid: 0000-0001-9435-2813
citation:
ama: Uecker H. Evolutionary rescue in randomly mating, selfing, and clonal populations.
Evolution. 2017;71(4):845-858. doi:10.1111/evo.13191
apa: Uecker, H. (2017). Evolutionary rescue in randomly mating, selfing, and clonal
populations. Evolution. Wiley-Blackwell. https://doi.org/10.1111/evo.13191
chicago: Uecker, Hildegard. “Evolutionary Rescue in Randomly Mating, Selfing, and
Clonal Populations.” Evolution. Wiley-Blackwell, 2017. https://doi.org/10.1111/evo.13191.
ieee: H. Uecker, “Evolutionary rescue in randomly mating, selfing, and clonal populations,”
Evolution, vol. 71, no. 4. Wiley-Blackwell, pp. 845–858, 2017.
ista: Uecker H. 2017. Evolutionary rescue in randomly mating, selfing, and clonal
populations. Evolution. 71(4), 845–858.
mla: Uecker, Hildegard. “Evolutionary Rescue in Randomly Mating, Selfing, and Clonal
Populations.” Evolution, vol. 71, no. 4, Wiley-Blackwell, 2017, pp. 845–58,
doi:10.1111/evo.13191.
short: H. Uecker, Evolution 71 (2017) 845–858.
date_created: 2018-12-11T11:49:57Z
date_published: 2017-04-01T00:00:00Z
date_updated: 2025-07-10T11:49:52Z
day: '01'
department:
- _id: NiBa
doi: 10.1111/evo.13191
ec_funded: 1
external_id:
isi:
- '000398545200003'
intvolume: ' 71'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://biorxiv.org/content/early/2016/10/14/081042
month: '04'
oa: 1
oa_version: Submitted Version
page: 845 - 858
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '250152'
name: Limits to selection in biology and in evolutionary computation
publication: Evolution
publication_identifier:
issn:
- 0014-3820
publication_status: published
publisher: Wiley-Blackwell
publist_id: '6327'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Evolutionary rescue in randomly mating, selfing, and clonal populations
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 71
year: '2017'
...
---
_id: '1065'
abstract:
- lang: eng
text: 'We consider the problem of reachability in pushdown graphs. We study the
problem for pushdown graphs with constant treewidth. Even for pushdown graphs
with treewidth 1, for the reachability problem we establish the following: (i)
the problem is PTIME-complete, and (ii) any subcubic algorithm for the problem
would contradict the k-clique conjecture and imply faster combinatorial algorithms
for cliques in graphs.'
article_processing_charge: No
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Georg F
full_name: Osang, Georg F
id: 464B40D6-F248-11E8-B48F-1D18A9856A87
last_name: Osang
orcid: 0000-0002-8882-5116
citation:
ama: Chatterjee K, Osang GF. Pushdown reachability with constant treewidth. Information
Processing Letters. 2017;122:25-29. doi:10.1016/j.ipl.2017.02.003
apa: Chatterjee, K., & Osang, G. F. (2017). Pushdown reachability with constant
treewidth. Information Processing Letters. Elsevier. https://doi.org/10.1016/j.ipl.2017.02.003
chicago: Chatterjee, Krishnendu, and Georg F Osang. “Pushdown Reachability with
Constant Treewidth.” Information Processing Letters. Elsevier, 2017. https://doi.org/10.1016/j.ipl.2017.02.003.
ieee: K. Chatterjee and G. F. Osang, “Pushdown reachability with constant treewidth,”
Information Processing Letters, vol. 122. Elsevier, pp. 25–29, 2017.
ista: Chatterjee K, Osang GF. 2017. Pushdown reachability with constant treewidth.
Information Processing Letters. 122, 25–29.
mla: Chatterjee, Krishnendu, and Georg F. Osang. “Pushdown Reachability with Constant
Treewidth.” Information Processing Letters, vol. 122, Elsevier, 2017, pp.
25–29, doi:10.1016/j.ipl.2017.02.003.
short: K. Chatterjee, G.F. Osang, Information Processing Letters 122 (2017) 25–29.
date_created: 2018-12-11T11:49:57Z
date_published: 2017-06-01T00:00:00Z
date_updated: 2025-07-10T11:49:53Z
day: '01'
ddc:
- '000'
department:
- _id: KrCh
- _id: HeEd
doi: 10.1016/j.ipl.2017.02.003
ec_funded: 1
external_id:
isi:
- '000399506600005'
file:
- access_level: open_access
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:13:17Z
date_updated: 2019-10-15T07:44:51Z
file_id: '4998'
file_name: IST-2018-991-v1+2_2018_Chatterjee_Pushdown_PREPRINT.pdf
file_size: 247657
relation: main_file
file_date_updated: 2019-10-15T07:44:51Z
has_accepted_license: '1'
intvolume: ' 122'
isi: 1
language:
- iso: eng
month: '06'
oa: 1
oa_version: Submitted Version
page: 25 - 29
project:
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
publication: Information Processing Letters
publication_identifier:
issn:
- 0020-0190
publication_status: published
publisher: Elsevier
publist_id: '6323'
pubrep_id: '991'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Pushdown reachability with constant treewidth
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 122
year: '2017'
...
---
OA_place: publisher
OA_type: free access
_id: '1066'
abstract:
- lang: eng
text: "Simulation is an attractive alternative to language inclusion for automata
as it is an under-approximation of language inclusion, but usually has much lower
complexity. Simulation has also been extended in two orthogonal directions, namely,
(1) fair simulation, for simulation over specified set of infinite runs; and (2)
quantitative simulation, for simulation between weighted automata. While fair
trace inclusion is PSPACE-complete, fair simulation can be computed in polynomial
time. For weighted automata, the (quantitative) language inclusion problem is
undecidable in general, whereas the (quantitative) simulation reduces to quantitative
games, which admit pseudo-polynomial time algorithms.\r\n\r\nIn this work, we
study (quantitative) simulation for weighted automata with Büchi acceptance conditions,
i.e., we generalize fair simulation from non-weighted automata to weighted automata.
We show that imposing Büchi acceptance conditions on weighted automata changes
many fundamental properties of the simulation games, yet they still admit pseudo-polynomial
time algorithms."
acknowledgement: This research was funded in part by the European Research Council
(ERC) under grant agreements 267989 (QUAREM), 279307 (Graph Games), by the Austrian
Science Fund (FWF) projects S11402-N23 (RiSE), S11407-N23 (RiSE), P23499-N23, and
Microsoft faculty fellows award.
article_processing_charge: No
article_type: original
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Jan
full_name: Otop, Jan
id: 2FC5DA74-F248-11E8-B48F-1D18A9856A87
last_name: Otop
- first_name: Yaron
full_name: Velner, Yaron
last_name: Velner
citation:
ama: Chatterjee K, Henzinger TA, Otop J, Velner Y. Quantitative fair simulation
games. Information and Computation. 2017;254(2):143-166. doi:10.1016/j.ic.2016.10.006
apa: Chatterjee, K., Henzinger, T. A., Otop, J., & Velner, Y. (2017). Quantitative
fair simulation games. Information and Computation. Elsevier. https://doi.org/10.1016/j.ic.2016.10.006
chicago: Chatterjee, Krishnendu, Thomas A Henzinger, Jan Otop, and Yaron Velner.
“Quantitative Fair Simulation Games.” Information and Computation. Elsevier,
2017. https://doi.org/10.1016/j.ic.2016.10.006.
ieee: K. Chatterjee, T. A. Henzinger, J. Otop, and Y. Velner, “Quantitative fair
simulation games,” Information and Computation, vol. 254, no. 2. Elsevier,
pp. 143–166, 2017.
ista: Chatterjee K, Henzinger TA, Otop J, Velner Y. 2017. Quantitative fair simulation
games. Information and Computation. 254(2), 143–166.
mla: Chatterjee, Krishnendu, et al. “Quantitative Fair Simulation Games.” Information
and Computation, vol. 254, no. 2, Elsevier, 2017, pp. 143–66, doi:10.1016/j.ic.2016.10.006.
short: K. Chatterjee, T.A. Henzinger, J. Otop, Y. Velner, Information and Computation
254 (2017) 143–166.
corr_author: '1'
date_created: 2018-12-11T11:49:58Z
date_published: 2017-06-01T00:00:00Z
date_updated: 2025-06-25T11:18:09Z
day: '01'
department:
- _id: KrCh
- _id: ToHe
doi: 10.1016/j.ic.2016.10.006
ec_funded: 1
external_id:
isi:
- '000402025600002'
intvolume: ' 254'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.ic.2016.10.006
month: '06'
oa: 1
oa_version: Published Version
page: 143 - 166
project:
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '267989'
name: Quantitative Reactive Modeling
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 2587B514-B435-11E9-9278-68D0E5697425
name: Microsoft Research Faculty Fellowship
publication: Information and Computation
publication_status: published
publisher: Elsevier
publist_id: '6322'
quality_controlled: '1'
related_material:
record:
- id: '5428'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Quantitative fair simulation games
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 254
year: '2017'
...
---
_id: '10663'
abstract:
- lang: eng
text: 'The superconducting state of matter enables one to observe quantum effects
on the macroscopic scale and hosts many fascinating phenomena. Topological defects
of the superconducting order parameter, such as vortices and fluxoid states in
multiply connected structures, are often the key ingredients of these phenomena.
This dissertation describes a new mode of magnetic force microscopy (Φ0-MFM) for
investigating vortex and fluxoid sates in mesoscopic superconducting (SC) structures.
The technique relies on the magneto-mechanical coupling of a MFM cantilever to
the motion of fluxons. The novelty of the technique is that a magnetic particle
attached to the cantilever is used not only to sense the state of a SC structure,
but also as a primary source of the inhomogeneous magnetic field which induces
that state. Φ0-MFM enables us to map the transitions between tip-induced states
during a scan: at the positions of the tip, where the two lowest energy states
become degenerate, small oscillations of the tip drive the transitions between
these states, which causes a significant shift in the resonant frequency and dissipation
of the cantilever. For narrow-wall aluminum rings, the mapped fluxoid transitions
form concentric contours on a scan. We show that the changes in the cantilever
resonant frequency and dissipation are well-described by a stochastic resonance
(SR) of cantilever-driven thermally activated phase slips (TAPS). The SR model
allows us to experimentally determine the rate of TAPS and compare it to the Langer-Ambegaokar-McCumber-Halperin
(LAMH) theory for TAPS in 1D superconducting structures. Further, we use the SR
model to qualitatively study the effects of a locally applied magnetic field on
the phase slip rate in rings containing constrictions. The states with multiple
vortices or winding numbers could be useful for the development of novel superconducting
devices, or the study of vortex interactions and interference effects. Using Φ0-MFM
allows us to induce, probe and control fluxoid states in thin wall structures
comprised of multiple loops. We show that Φ0-MFM images of the fluxoid transitions
allow us to identify the underlying states and to investigate their energetics
and dynamics even in complicated structures.'
alternative_title:
- Graduate Dissertations and Theses at Illinois
article_processing_charge: No
author:
- first_name: Hryhoriy
full_name: Polshyn, Hryhoriy
id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
last_name: Polshyn
orcid: 0000-0001-8223-8896
citation:
ama: Polshyn H. Magnetic force microscopy studies of mesoscopic superconducting
structures. 2017.
apa: Polshyn, H. (2017). Magnetic force microscopy studies of mesoscopic superconducting
structures. University of Illinois at Urbana-Champaign.
chicago: Polshyn, Hryhoriy. “Magnetic Force Microscopy Studies of Mesoscopic Superconducting
Structures.” University of Illinois at Urbana-Champaign, 2017.
ieee: H. Polshyn, “Magnetic force microscopy studies of mesoscopic superconducting
structures,” University of Illinois at Urbana-Champaign, 2017.
ista: Polshyn H. 2017. Magnetic force microscopy studies of mesoscopic superconducting
structures. University of Illinois at Urbana-Champaign.
mla: Polshyn, Hryhoriy. Magnetic Force Microscopy Studies of Mesoscopic Superconducting
Structures. University of Illinois at Urbana-Champaign, 2017.
short: H. Polshyn, Magnetic Force Microscopy Studies of Mesoscopic Superconducting
Structures, University of Illinois at Urbana-Champaign, 2017.
date_created: 2022-01-25T14:54:14Z
date_published: 2017-09-18T00:00:00Z
date_updated: 2024-10-14T11:13:43Z
day: '18'
degree_awarded: PhD
extern: '1'
keyword:
- physics
- superconductivity
- magnetic force microscopy
- phase slips
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://hdl.handle.net/2142/99178
month: '09'
oa: 1
oa_version: Published Version
page: '103'
publication_status: published
publisher: University of Illinois at Urbana-Champaign
status: public
supervisor:
- first_name: Raffi
full_name: Budakian, Raffi
last_name: Budakian
title: Magnetic force microscopy studies of mesoscopic superconducting structures
type: dissertation
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2017'
...
---
_id: '1067'
abstract:
- lang: eng
text: Embryo morphogenesis relies on highly coordinated movements of different tissues.
However, remarkably little is known about how tissues coordinate their movements
to shape the embryo. In zebrafish embryogenesis, coordinated tissue movements
first become apparent during “doming,” when the blastoderm begins to spread over
the yolk sac, a process involving coordinated epithelial surface cell layer expansion
and mesenchymal deep cell intercalations. Here, we find that active surface cell
expansion represents the key process coordinating tissue movements during doming.
By using a combination of theory and experiments, we show that epithelial surface
cells not only trigger blastoderm expansion by reducing tissue surface tension,
but also drive blastoderm thinning by inducing tissue contraction through radial
deep cell intercalations. Thus, coordinated tissue expansion and thinning during
doming relies on surface cells simultaneously controlling tissue surface tension
and radial tissue contraction.
acknowledged_ssus:
- _id: PreCl
article_processing_charge: No
author:
- first_name: Hitoshi
full_name: Morita, Hitoshi
id: 4C6E54C6-F248-11E8-B48F-1D18A9856A87
last_name: Morita
- first_name: Silvia
full_name: Grigolon, Silvia
last_name: Grigolon
- first_name: Martin
full_name: Bock, Martin
last_name: Bock
- first_name: Gabriel
full_name: Krens, Gabriel
id: 2B819732-F248-11E8-B48F-1D18A9856A87
last_name: Krens
orcid: 0000-0003-4761-5996
- first_name: Guillaume
full_name: Salbreux, Guillaume
last_name: Salbreux
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Morita H, Grigolon S, Bock M, Krens G, Salbreux G, Heisenberg C-PJ. The physical
basis of coordinated tissue spreading in zebrafish gastrulation. Developmental
Cell. 2017;40(4):354-366. doi:10.1016/j.devcel.2017.01.010
apa: Morita, H., Grigolon, S., Bock, M., Krens, G., Salbreux, G., & Heisenberg,
C.-P. J. (2017). The physical basis of coordinated tissue spreading in zebrafish
gastrulation. Developmental Cell. Cell Press. https://doi.org/10.1016/j.devcel.2017.01.010
chicago: Morita, Hitoshi, Silvia Grigolon, Martin Bock, Gabriel Krens, Guillaume
Salbreux, and Carl-Philipp J Heisenberg. “The Physical Basis of Coordinated Tissue
Spreading in Zebrafish Gastrulation.” Developmental Cell. Cell Press, 2017.
https://doi.org/10.1016/j.devcel.2017.01.010.
ieee: H. Morita, S. Grigolon, M. Bock, G. Krens, G. Salbreux, and C.-P. J. Heisenberg,
“The physical basis of coordinated tissue spreading in zebrafish gastrulation,”
Developmental Cell, vol. 40, no. 4. Cell Press, pp. 354–366, 2017.
ista: Morita H, Grigolon S, Bock M, Krens G, Salbreux G, Heisenberg C-PJ. 2017.
The physical basis of coordinated tissue spreading in zebrafish gastrulation.
Developmental Cell. 40(4), 354–366.
mla: Morita, Hitoshi, et al. “The Physical Basis of Coordinated Tissue Spreading
in Zebrafish Gastrulation.” Developmental Cell, vol. 40, no. 4, Cell Press,
2017, pp. 354–66, doi:10.1016/j.devcel.2017.01.010.
short: H. Morita, S. Grigolon, M. Bock, G. Krens, G. Salbreux, C.-P.J. Heisenberg,
Developmental Cell 40 (2017) 354–366.
corr_author: '1'
date_created: 2018-12-11T11:49:58Z
date_published: 2017-02-27T00:00:00Z
date_updated: 2025-07-10T11:49:55Z
day: '27'
ddc:
- '572'
- '597'
department:
- _id: CaHe
doi: 10.1016/j.devcel.2017.01.010
ec_funded: 1
external_id:
isi:
- '000395368300007'
file:
- access_level: open_access
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:10:57Z
date_updated: 2018-12-12T10:10:57Z
file_id: '4849'
file_name: IST-2017-869-v1+1_1-s2.0-S1534580717300370-main.pdf
file_size: 6866187
relation: main_file
file_date_updated: 2018-12-12T10:10:57Z
has_accepted_license: '1'
intvolume: ' 40'
isi: 1
issue: '4'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 354 - 366
project:
- _id: 2524F500-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '201439'
name: Developing High-Throughput Bioassays for Human Cancers in Zebrafish
publication: Developmental Cell
publication_identifier:
issn:
- 1534-5807
publication_status: published
publisher: Cell Press
publist_id: '6320'
pubrep_id: '869'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The physical basis of coordinated tissue spreading in zebrafish gastrulation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 40
year: '2017'
...
---
_id: '1072'
abstract:
- lang: eng
text: Given a finite set of points in Rn and a radius parameter, we study the Čech,
Delaunay–Čech, Delaunay (or alpha), and Wrap complexes in the light of generalized
discrete Morse theory. Establishing the Čech and Delaunay complexes as sublevel
sets of generalized discrete Morse functions, we prove that the four complexes
are simple-homotopy equivalent by a sequence of simplicial collapses, which are
explicitly described by a single discrete gradient field.
acknowledgement: This research has been supported by the EU project Toposys(FP7-ICT-318493-STREP),
by ESF under the ACAT Research Network Programme, by the Russian Government under
mega project 11.G34.31.0053, and by the DFG Collaborative Research Center SFB/TRR
109 “Discretization in Geometry and Dynamics”.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Ulrich
full_name: Bauer, Ulrich
id: 2ADD483A-F248-11E8-B48F-1D18A9856A87
last_name: Bauer
orcid: 0000-0002-9683-0724
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: Bauer U, Edelsbrunner H. The Morse theory of Čech and delaunay complexes. Transactions
of the American Mathematical Society. 2017;369(5):3741-3762. doi:10.1090/tran/6991
apa: Bauer, U., & Edelsbrunner, H. (2017). The Morse theory of Čech and delaunay
complexes. Transactions of the American Mathematical Society. American
Mathematical Society. https://doi.org/10.1090/tran/6991
chicago: Bauer, Ulrich, and Herbert Edelsbrunner. “The Morse Theory of Čech and
Delaunay Complexes.” Transactions of the American Mathematical Society.
American Mathematical Society, 2017. https://doi.org/10.1090/tran/6991.
ieee: U. Bauer and H. Edelsbrunner, “The Morse theory of Čech and delaunay complexes,”
Transactions of the American Mathematical Society, vol. 369, no. 5. American
Mathematical Society, pp. 3741–3762, 2017.
ista: Bauer U, Edelsbrunner H. 2017. The Morse theory of Čech and delaunay complexes.
Transactions of the American Mathematical Society. 369(5), 3741–3762.
mla: Bauer, Ulrich, and Herbert Edelsbrunner. “The Morse Theory of Čech and Delaunay
Complexes.” Transactions of the American Mathematical Society, vol. 369,
no. 5, American Mathematical Society, 2017, pp. 3741–62, doi:10.1090/tran/6991.
short: U. Bauer, H. Edelsbrunner, Transactions of the American Mathematical Society
369 (2017) 3741–3762.
date_created: 2018-12-11T11:49:59Z
date_published: 2017-05-01T00:00:00Z
date_updated: 2025-04-15T08:37:54Z
day: '01'
department:
- _id: HeEd
doi: 10.1090/tran/6991
ec_funded: 1
external_id:
arxiv:
- '1312.1231'
isi:
- '000398030400024'
intvolume: ' 369'
isi: 1
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1312.1231
month: '05'
oa: 1
oa_version: Preprint
page: 3741 - 3762
project:
- _id: 255D761E-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '318493'
name: Topological Complex Systems
publication: Transactions of the American Mathematical Society
publication_status: published
publisher: American Mathematical Society
publist_id: '6311'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The Morse theory of Čech and delaunay complexes
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 369
year: '2017'
...
---
_id: '1073'
abstract:
- lang: eng
text: Let X and Y be finite simplicial sets (e.g. finite simplicial complexes),
both equipped with a free simplicial action of a finite group G. Assuming that
Y is d-connected and dimX≤2d, for some d≥1, we provide an algorithm that computes
the set of all equivariant homotopy classes of equivariant continuous maps |X|→|Y|;
the existence of such a map can be decided even for dimX≤2d+1. This yields the
first algorithm for deciding topological embeddability of a k-dimensional finite
simplicial complex into Rn under the condition k≤23n−1. More generally, we present
an algorithm that, given a lifting-extension problem satisfying an appropriate
stability assumption, computes the set of all homotopy classes of solutions. This
result is new even in the non-equivariant situation.
article_processing_charge: No
arxiv: 1
author:
- first_name: Martin
full_name: Čadek, Martin
last_name: Čadek
- first_name: Marek
full_name: Krcál, Marek
id: 33E21118-F248-11E8-B48F-1D18A9856A87
last_name: Krcál
- first_name: Lukáš
full_name: Vokřínek, Lukáš
last_name: Vokřínek
citation:
ama: Čadek M, Krcál M, Vokřínek L. Algorithmic solvability of the lifting extension
problem. Discrete & Computational Geometry. 2017;54(4):915-965. doi:10.1007/s00454-016-9855-6
apa: Čadek, M., Krcál, M., & Vokřínek, L. (2017). Algorithmic solvability of
the lifting extension problem. Discrete & Computational Geometry. Springer.
https://doi.org/10.1007/s00454-016-9855-6
chicago: Čadek, Martin, Marek Krcál, and Lukáš Vokřínek. “Algorithmic Solvability
of the Lifting Extension Problem.” Discrete & Computational Geometry.
Springer, 2017. https://doi.org/10.1007/s00454-016-9855-6.
ieee: M. Čadek, M. Krcál, and L. Vokřínek, “Algorithmic solvability of the lifting
extension problem,” Discrete & Computational Geometry, vol. 54, no.
4. Springer, pp. 915–965, 2017.
ista: Čadek M, Krcál M, Vokřínek L. 2017. Algorithmic solvability of the lifting
extension problem. Discrete & Computational Geometry. 54(4), 915–965.
mla: Čadek, Martin, et al. “Algorithmic Solvability of the Lifting Extension Problem.”
Discrete & Computational Geometry, vol. 54, no. 4, Springer, 2017,
pp. 915–65, doi:10.1007/s00454-016-9855-6.
short: M. Čadek, M. Krcál, L. Vokřínek, Discrete & Computational Geometry 54
(2017) 915–965.
date_created: 2018-12-11T11:50:00Z
date_published: 2017-06-01T00:00:00Z
date_updated: 2025-06-04T08:11:10Z
day: '01'
department:
- _id: UlWa
doi: 10.1007/s00454-016-9855-6
external_id:
arxiv:
- '1307.6444'
isi:
- '000400072700008'
intvolume: ' 54'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1307.6444
month: '06'
oa: 1
oa_version: Submitted Version
page: 915 - 965
publication: Discrete & Computational Geometry
publication_identifier:
issn:
- '01795376'
publication_status: published
publisher: Springer
publist_id: '6309'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Algorithmic solvability of the lifting extension problem
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 54
year: '2017'
...