---
_id: '63'
abstract:
- lang: eng
  text: African cichlids display a remarkable assortment of jaw morphologies, pigmentation
    patterns, and mating behaviors. In addition to this previously documented diversity,
    recent studies have documented a rich diversity of sex chromosomes within these
    fishes. Here we review the known sex-determination network within vertebrates,
    and the extraordinary number of sex chromosomes systems segregating in African
    cichlids. We also propose a model for understanding the unusual number of sex
    chromosome systems within this clade.
acknowledgement: NSF DEB-1830753 and ISTPlus Fellowship
article_number: '480'
article_processing_charge: No
author:
- first_name: William J
  full_name: Gammerdinger, William J
  id: 3A7E01BC-F248-11E8-B48F-1D18A9856A87
  last_name: Gammerdinger
  orcid: 0000-0001-9638-1220
- first_name: Thomas
  full_name: Kocher, Thomas
  last_name: Kocher
citation:
  ama: Gammerdinger WJ, Kocher T. Unusual diversity of sex chromosomes in African
    cichlid fishes. <i>Genes</i>. 2018;9(10). doi:<a href="https://doi.org/10.3390/genes9100480">10.3390/genes9100480</a>
  apa: Gammerdinger, W. J., &#38; Kocher, T. (2018). Unusual diversity of sex chromosomes
    in African cichlid fishes. <i>Genes</i>. MDPI. <a href="https://doi.org/10.3390/genes9100480">https://doi.org/10.3390/genes9100480</a>
  chicago: Gammerdinger, William J, and Thomas Kocher. “Unusual Diversity of Sex Chromosomes
    in African Cichlid Fishes.” <i>Genes</i>. MDPI, 2018. <a href="https://doi.org/10.3390/genes9100480">https://doi.org/10.3390/genes9100480</a>.
  ieee: W. J. Gammerdinger and T. Kocher, “Unusual diversity of sex chromosomes in
    African cichlid fishes,” <i>Genes</i>, vol. 9, no. 10. MDPI, 2018.
  ista: Gammerdinger WJ, Kocher T. 2018. Unusual diversity of sex chromosomes in African
    cichlid fishes. Genes. 9(10), 480.
  mla: Gammerdinger, William J., and Thomas Kocher. “Unusual Diversity of Sex Chromosomes
    in African Cichlid Fishes.” <i>Genes</i>, vol. 9, no. 10, 480, MDPI, 2018, doi:<a
    href="https://doi.org/10.3390/genes9100480">10.3390/genes9100480</a>.
  short: W.J. Gammerdinger, T. Kocher, Genes 9 (2018).
date_created: 2018-12-11T11:44:26Z
date_published: 2018-10-04T00:00:00Z
date_updated: 2025-04-15T06:50:01Z
day: '04'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.3390/genes9100480
ec_funded: 1
external_id:
  isi:
  - '000448656700018'
file:
- access_level: open_access
  checksum: bec527692e2c9b56919c0429634ff337
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-18T09:54:46Z
  date_updated: 2020-07-14T12:47:27Z
  file_id: '5743'
  file_name: 2018_Genes_Gammerdinger.pdf
  file_size: 1415791
  relation: main_file
file_date_updated: 2020-07-14T12:47:27Z
fulldoi: https://doi.org/10.3390/genes9100480
has_accepted_license: '1'
intvolume: '         9'
isi: 1
issue: '10'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: Genes
publication_status: published
publisher: MDPI
publist_id: '7991'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Unusual diversity of sex chromosomes in African cichlid fishes
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2018'
...
---
_id: '6339'
abstract:
- lang: eng
  text: We introduce a diagrammatic Monte Carlo approach to angular momentum properties
    of quantum many-particle systems possessing a macroscopic number of degrees of
    freedom. The treatment is based on a diagrammatic expansion that merges the usual
    Feynman diagrams with the angular momentum diagrams known from atomic and nuclear
    structure theory, thereby incorporating the non-Abelian algebra inherent to quantum
    rotations. Our approach is applicable at arbitrary coupling, is free of systematic
    errors and of finite-size effects, and naturally provides access to the impurity
    Green function. We exemplify the technique by obtaining an all-coupling solution
    of the angulon model; however, the method is quite general and can be applied
    to a broad variety of systems in which particles exchange quantum angular momentum
    with their many-body environment.
article_number: '165301'
article_processing_charge: No
arxiv: 1
author:
- first_name: Giacomo
  full_name: Bighin, Giacomo
  id: 4CA96FD4-F248-11E8-B48F-1D18A9856A87
  last_name: Bighin
  orcid: 0000-0001-8823-9777
- first_name: Timur
  full_name: Tscherbul, Timur
  last_name: Tscherbul
- first_name: Mikhail
  full_name: Lemeshko, Mikhail
  id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
  last_name: Lemeshko
  orcid: 0000-0002-6990-7802
citation:
  ama: Bighin G, Tscherbul T, Lemeshko M. Diagrammatic Monte Carlo approach to angular
    momentum in quantum many-particle systems. <i>Physical Review Letters</i>. 2018;121(16).
    doi:<a href="https://doi.org/10.1103/physrevlett.121.165301">10.1103/physrevlett.121.165301</a>
  apa: Bighin, G., Tscherbul, T., &#38; Lemeshko, M. (2018). Diagrammatic Monte Carlo
    approach to angular momentum in quantum many-particle systems. <i>Physical Review
    Letters</i>. American Physical Society. <a href="https://doi.org/10.1103/physrevlett.121.165301">https://doi.org/10.1103/physrevlett.121.165301</a>
  chicago: Bighin, Giacomo, Timur Tscherbul, and Mikhail Lemeshko. “Diagrammatic Monte Carlo
    Approach to Angular Momentum in Quantum Many-Particle Systems.” <i>Physical Review
    Letters</i>. American Physical Society, 2018. <a href="https://doi.org/10.1103/physrevlett.121.165301">https://doi.org/10.1103/physrevlett.121.165301</a>.
  ieee: G. Bighin, T. Tscherbul, and M. Lemeshko, “Diagrammatic Monte Carlo approach
    to angular momentum in quantum many-particle systems,” <i>Physical Review Letters</i>,
    vol. 121, no. 16. American Physical Society, 2018.
  ista: Bighin G, Tscherbul T, Lemeshko M. 2018. Diagrammatic Monte Carlo approach
    to angular momentum in quantum many-particle systems. Physical Review Letters.
    121(16), 165301.
  mla: Bighin, Giacomo, et al. “Diagrammatic Monte Carlo Approach to Angular Momentum
    in Quantum Many-Particle Systems.” <i>Physical Review Letters</i>, vol. 121, no.
    16, 165301, American Physical Society, 2018, doi:<a href="https://doi.org/10.1103/physrevlett.121.165301">10.1103/physrevlett.121.165301</a>.
  short: G. Bighin, T. Tscherbul, M. Lemeshko, Physical Review Letters 121 (2018).
date_created: 2019-04-17T10:53:38Z
date_published: 2018-10-16T00:00:00Z
date_updated: 2025-04-15T07:59:29Z
day: '16'
department:
- _id: MiLe
doi: 10.1103/physrevlett.121.165301
external_id:
  arxiv:
  - '1803.07990'
  isi:
  - '000447468400008'
fulldoi: https://doi.org/10.1103/physrevlett.121.165301
intvolume: '       121'
isi: 1
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1803.07990
month: '10'
oa: 1
oa_version: Preprint
project:
- _id: 26031614-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P29902
  name: Quantum rotations in the presence of a many-body environment
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/description-of-rotating-molecules-made-easy/
scopus_import: '1'
status: public
title: Diagrammatic Monte Carlo approach to angular momentum in quantum many-particle
  systems
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 121
year: '2018'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '6354'
abstract:
- lang: eng
  text: Blood platelets are critical for hemostasis and thrombosis, but also play
    diverse roles during immune responses. We have recently reported that platelets
    migrate at sites of infection in vitro and in vivo. Importantly, platelets use
    their ability to migrate to collect and bundle fibrin (ogen)-bound bacteria accomplishing
    efficient intravascular bacterial trapping. Here, we describe a method that allows
    analyzing platelet migration in vitro, focusing on their ability to collect bacteria
    and trap bacteria under flow.
acknowledgement: This protocol was adapted from a previously published study (Gaertner
  et al., 2017). We thank Michael Lorenz for his excellent assistance in bacteria
  culture. This work was funded by the DFG SFB 914 (S.M. [B02 and Z01]), the DFG SFB
  1123 (S.M. [B06]), the DFG FOR 2033 (S.M. and F.G.), the German Centre for Cardiovascular
  Research (DZHK) (MHA 1.4VD [S.M.]), FP7 program (project 260309, PRESTIGE [S.M.]),
  FöFoLe project 947 (F.G.), the Friedrich-Baur-Stiftung project 41/16 (F.G.), Marie
  Sklodowska Curie Individual Fellowship (EU project 747687, LamelliaActin [F.G.]).
article_number: e3018
article_processing_charge: Yes
article_type: original
author:
- first_name: Shuxia
  full_name: Fan, Shuxia
  last_name: Fan
- first_name: Michael
  full_name: Lorenz, Michael
  last_name: Lorenz
- first_name: Steffen
  full_name: Massberg, Steffen
  last_name: Massberg
- first_name: Florian R
  full_name: Gärtner, Florian R
  id: 397A88EE-F248-11E8-B48F-1D18A9856A87
  last_name: Gärtner
  orcid: 0000-0001-6120-3723
citation:
  ama: Fan S, Lorenz M, Massberg S, Gärtner FR. Platelet migration and bacterial trapping
    assay under flow. <i>Bio-Protocol</i>. 2018;8(18). doi:<a href="https://doi.org/10.21769/bioprotoc.3018">10.21769/bioprotoc.3018</a>
  apa: Fan, S., Lorenz, M., Massberg, S., &#38; Gärtner, F. R. (2018). Platelet migration
    and bacterial trapping assay under flow. <i>Bio-Protocol</i>. Bio-Protocol. <a
    href="https://doi.org/10.21769/bioprotoc.3018">https://doi.org/10.21769/bioprotoc.3018</a>
  chicago: Fan, Shuxia, Michael Lorenz, Steffen Massberg, and Florian R Gärtner. “Platelet
    Migration and Bacterial Trapping Assay under Flow.” <i>Bio-Protocol</i>. Bio-Protocol,
    2018. <a href="https://doi.org/10.21769/bioprotoc.3018">https://doi.org/10.21769/bioprotoc.3018</a>.
  ieee: S. Fan, M. Lorenz, S. Massberg, and F. R. Gärtner, “Platelet migration and
    bacterial trapping assay under flow,” <i>Bio-Protocol</i>, vol. 8, no. 18. Bio-Protocol,
    2018.
  ista: Fan S, Lorenz M, Massberg S, Gärtner FR. 2018. Platelet migration and bacterial
    trapping assay under flow. Bio-Protocol. 8(18), e3018.
  mla: Fan, Shuxia, et al. “Platelet Migration and Bacterial Trapping Assay under
    Flow.” <i>Bio-Protocol</i>, vol. 8, no. 18, e3018, Bio-Protocol, 2018, doi:<a
    href="https://doi.org/10.21769/bioprotoc.3018">10.21769/bioprotoc.3018</a>.
  short: S. Fan, M. Lorenz, S. Massberg, F.R. Gärtner, Bio-Protocol 8 (2018).
corr_author: '1'
date_created: 2019-04-29T09:40:33Z
date_published: 2018-09-20T00:00:00Z
date_updated: 2025-05-20T07:43:06Z
day: '20'
ddc:
- '570'
department:
- _id: MiSi
doi: 10.21769/bioprotoc.3018
ec_funded: 1
external_id:
  pmid:
  - '34395806'
file:
- access_level: open_access
  checksum: d4588377e789da7f360b553ae02c5119
  content_type: application/pdf
  creator: dernst
  date_created: 2019-04-30T08:04:33Z
  date_updated: 2020-07-14T12:47:28Z
  file_id: '6360'
  file_name: 2018_BioProtocol_Fan.pdf
  file_size: 2928337
  relation: main_file
file_date_updated: 2020-07-14T12:47:28Z
fulldoi: https://doi.org/10.21769/bioprotoc.3018
has_accepted_license: '1'
intvolume: '         8'
issue: '18'
keyword:
- Platelets
- Cell migration
- Bacteria
- Shear flow
- Fibrinogen
- E. coli
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 260AA4E2-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '747687'
  name: Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells
publication: Bio-Protocol
publication_identifier:
  issn:
  - 2331-8325
publication_status: published
publisher: Bio-Protocol
quality_controlled: '1'
status: public
title: Platelet migration and bacterial trapping assay under flow
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2018'
...
---
_id: '6355'
abstract:
- lang: eng
  text: We  prove  that  any  cyclic  quadrilateral  can  be  inscribed  in  any  closed  convex
    C1-curve.  The smoothness condition is not required if the quadrilateral is a
    rectangle.
article_number: e7
article_processing_charge: No
arxiv: 1
author:
- first_name: Arseniy
  full_name: Akopyan, Arseniy
  id: 430D2C90-F248-11E8-B48F-1D18A9856A87
  last_name: Akopyan
  orcid: 0000-0002-2548-617X
- first_name: Sergey
  full_name: Avvakumov, Sergey
  id: 3827DAC8-F248-11E8-B48F-1D18A9856A87
  last_name: Avvakumov
  orcid: 0000-0002-7840-5062
citation:
  ama: Akopyan A, Avvakumov S. Any cyclic quadrilateral can be inscribed in any closed
    convex smooth curve. <i>Forum of Mathematics, Sigma</i>. 2018;6. doi:<a href="https://doi.org/10.1017/fms.2018.7">10.1017/fms.2018.7</a>
  apa: Akopyan, A., &#38; Avvakumov, S. (2018). Any cyclic quadrilateral can be inscribed
    in any closed convex smooth curve. <i>Forum of Mathematics, Sigma</i>. Cambridge
    University Press. <a href="https://doi.org/10.1017/fms.2018.7">https://doi.org/10.1017/fms.2018.7</a>
  chicago: Akopyan, Arseniy, and Sergey Avvakumov. “Any Cyclic Quadrilateral Can Be
    Inscribed in Any Closed Convex Smooth Curve.” <i>Forum of Mathematics, Sigma</i>.
    Cambridge University Press, 2018. <a href="https://doi.org/10.1017/fms.2018.7">https://doi.org/10.1017/fms.2018.7</a>.
  ieee: A. Akopyan and S. Avvakumov, “Any cyclic quadrilateral can be inscribed in
    any closed convex smooth curve,” <i>Forum of Mathematics, Sigma</i>, vol. 6. Cambridge
    University Press, 2018.
  ista: Akopyan A, Avvakumov S. 2018. Any cyclic quadrilateral can be inscribed in
    any closed convex smooth curve. Forum of Mathematics, Sigma. 6, e7.
  mla: Akopyan, Arseniy, and Sergey Avvakumov. “Any Cyclic Quadrilateral Can Be Inscribed
    in Any Closed Convex Smooth Curve.” <i>Forum of Mathematics, Sigma</i>, vol. 6,
    e7, Cambridge University Press, 2018, doi:<a href="https://doi.org/10.1017/fms.2018.7">10.1017/fms.2018.7</a>.
  short: A. Akopyan, S. Avvakumov, Forum of Mathematics, Sigma 6 (2018).
corr_author: '1'
date_created: 2019-04-30T06:09:57Z
date_published: 2018-05-31T00:00:00Z
date_updated: 2026-04-08T07:25:54Z
day: '31'
ddc:
- '510'
department:
- _id: UlWa
- _id: HeEd
- _id: JaMa
doi: 10.1017/fms.2018.7
ec_funded: 1
external_id:
  arxiv:
  - '1712.10205'
  isi:
  - '000433915500001'
file:
- access_level: open_access
  checksum: 5a71b24ba712a3eb2e46165a38fbc30a
  content_type: application/pdf
  creator: dernst
  date_created: 2019-04-30T06:14:58Z
  date_updated: 2020-07-14T12:47:28Z
  file_id: '6356'
  file_name: 2018_ForumMahtematics_Akopyan.pdf
  file_size: 249246
  relation: main_file
file_date_updated: 2020-07-14T12:47:28Z
fulldoi: https://doi.org/10.1017/fms.2018.7
has_accepted_license: '1'
intvolume: '         6'
isi: 1
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
project:
- _id: 256E75B8-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '716117'
  name: Optimal Transport and Stochastic Dynamics
publication: Forum of Mathematics, Sigma
publication_identifier:
  issn:
  - 2050-5094
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
related_material:
  record:
  - id: '8156'
    relation: dissertation_contains
    status: public
status: public
title: Any cyclic quadrilateral can be inscribed in any closed convex smooth curve
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 6
year: '2018'
...
---
_id: '6368'
abstract:
- lang: eng
  text: An optical network of superconducting quantum bits (qubits) is an appealing
    platform for quantum communication and distributed quantum computing, but developing
    a quantum-compatible link between the microwave and optical domains remains an
    outstanding challenge. Operating at T < 100 mK temperatures, as required for quantum
    electrical circuits, we demonstrate a mechanically mediated microwave–optical
    converter with 47% conversion efficiency, and use a classical feed-forward protocol
    to reduce added noise to 38 photons. The feed-forward protocol harnesses our discovery
    that noise emitted from the two converter output ports is strongly correlated
    because both outputs record thermal motion of the same mechanical mode. We also
    discuss a quantum feed-forward protocol that, given high system efficiencies,
    would allow quantum information to be transferred even when thermal phonons enter
    the mechanical element faster than the electro-optic conversion rate.
arxiv: 1
author:
- first_name: Andrew P
  full_name: Higginbotham, Andrew P
  id: 4AD6785A-F248-11E8-B48F-1D18A9856A87
  last_name: Higginbotham
  orcid: 0000-0003-2607-2363
- first_name: P. S.
  full_name: Burns, P. S.
  last_name: Burns
- first_name: M. D.
  full_name: Urmey, M. D.
  last_name: Urmey
- first_name: R. W.
  full_name: Peterson, R. W.
  last_name: Peterson
- first_name: N. S.
  full_name: Kampel, N. S.
  last_name: Kampel
- first_name: B. M.
  full_name: Brubaker, B. M.
  last_name: Brubaker
- first_name: G.
  full_name: Smith, G.
  last_name: Smith
- first_name: K. W.
  full_name: Lehnert, K. W.
  last_name: Lehnert
- first_name: C. A.
  full_name: Regal, C. A.
  last_name: Regal
citation:
  ama: Higginbotham AP, Burns PS, Urmey MD, et al. Harnessing electro-optic correlations
    in an efficient mechanical converter. <i>Nature Physics</i>. 2018;14(10):1038-1042.
    doi:<a href="https://doi.org/10.1038/s41567-018-0210-0">10.1038/s41567-018-0210-0</a>
  apa: Higginbotham, A. P., Burns, P. S., Urmey, M. D., Peterson, R. W., Kampel, N.
    S., Brubaker, B. M., … Regal, C. A. (2018). Harnessing electro-optic correlations
    in an efficient mechanical converter. <i>Nature Physics</i>. Springer Nature.
    <a href="https://doi.org/10.1038/s41567-018-0210-0">https://doi.org/10.1038/s41567-018-0210-0</a>
  chicago: Higginbotham, Andrew P, P. S. Burns, M. D. Urmey, R. W. Peterson, N. S.
    Kampel, B. M. Brubaker, G. Smith, K. W. Lehnert, and C. A. Regal. “Harnessing
    Electro-Optic Correlations in an Efficient Mechanical Converter.” <i>Nature Physics</i>.
    Springer Nature, 2018. <a href="https://doi.org/10.1038/s41567-018-0210-0">https://doi.org/10.1038/s41567-018-0210-0</a>.
  ieee: A. P. Higginbotham <i>et al.</i>, “Harnessing electro-optic correlations in
    an efficient mechanical converter,” <i>Nature Physics</i>, vol. 14, no. 10. Springer
    Nature, pp. 1038–1042, 2018.
  ista: Higginbotham AP, Burns PS, Urmey MD, Peterson RW, Kampel NS, Brubaker BM,
    Smith G, Lehnert KW, Regal CA. 2018. Harnessing electro-optic correlations in
    an efficient mechanical converter. Nature Physics. 14(10), 1038–1042.
  mla: Higginbotham, Andrew P., et al. “Harnessing Electro-Optic Correlations in an
    Efficient Mechanical Converter.” <i>Nature Physics</i>, vol. 14, no. 10, Springer
    Nature, 2018, pp. 1038–42, doi:<a href="https://doi.org/10.1038/s41567-018-0210-0">10.1038/s41567-018-0210-0</a>.
  short: A.P. Higginbotham, P.S. Burns, M.D. Urmey, R.W. Peterson, N.S. Kampel, B.M.
    Brubaker, G. Smith, K.W. Lehnert, C.A. Regal, Nature Physics 14 (2018) 1038–1042.
date_created: 2019-05-03T09:17:20Z
date_published: 2018-10-01T00:00:00Z
date_updated: 2021-01-12T08:07:15Z
day: '01'
doi: 10.1038/s41567-018-0210-0
extern: '1'
external_id:
  arxiv:
  - '1712.06535'
fulldoi: https://doi.org/10.1038/s41567-018-0210-0
intvolume: '        14'
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1712.06535
month: '10'
oa: 1
oa_version: Preprint
page: 1038-1042
publication: Nature Physics
publication_identifier:
  issn:
  - 1745-2473
  - 1745-2481
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Harnessing electro-optic correlations in an efficient mechanical converter
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2018'
...
---
_id: '6369'
abstract:
- lang: eng
  text: We construct a metamaterial from radio-frequency harmonic oscillators, and
    find two topologically distinct phases resulting from dissipation engineered into
    the system. These phases are distinguished by a quantized value of bulk energy
    transport. The impulse response of our circuit is measured and used to reconstruct
    the band structure and winding number of circuit eigenfunctions around a dark
    mode. Our results demonstrate that dissipative topological transport can occur
    in a wider class of physical systems than considered before.
article_number: '220301'
arxiv: 1
author:
- first_name: Eric I.
  full_name: Rosenthal, Eric I.
  last_name: Rosenthal
- first_name: Nicole K.
  full_name: Ehrlich, Nicole K.
  last_name: Ehrlich
- first_name: Mark S.
  full_name: Rudner, Mark S.
  last_name: Rudner
- first_name: Andrew P
  full_name: Higginbotham, Andrew P
  id: 4AD6785A-F248-11E8-B48F-1D18A9856A87
  last_name: Higginbotham
  orcid: 0000-0003-2607-2363
- first_name: K. W.
  full_name: Lehnert, K. W.
  last_name: Lehnert
citation:
  ama: Rosenthal EI, Ehrlich NK, Rudner MS, Higginbotham AP, Lehnert KW. Topological
    phase transition measured in a dissipative metamaterial. <i>Physical Review B</i>.
    2018;97(22). doi:<a href="https://doi.org/10.1103/physrevb.97.220301">10.1103/physrevb.97.220301</a>
  apa: Rosenthal, E. I., Ehrlich, N. K., Rudner, M. S., Higginbotham, A. P., &#38;
    Lehnert, K. W. (2018). Topological phase transition measured in a dissipative
    metamaterial. <i>Physical Review B</i>. American Physical Society (APS). <a href="https://doi.org/10.1103/physrevb.97.220301">https://doi.org/10.1103/physrevb.97.220301</a>
  chicago: Rosenthal, Eric I., Nicole K. Ehrlich, Mark S. Rudner, Andrew P Higginbotham,
    and K. W. Lehnert. “Topological Phase Transition Measured in a Dissipative Metamaterial.”
    <i>Physical Review B</i>. American Physical Society (APS), 2018. <a href="https://doi.org/10.1103/physrevb.97.220301">https://doi.org/10.1103/physrevb.97.220301</a>.
  ieee: E. I. Rosenthal, N. K. Ehrlich, M. S. Rudner, A. P. Higginbotham, and K. W.
    Lehnert, “Topological phase transition measured in a dissipative metamaterial,”
    <i>Physical Review B</i>, vol. 97, no. 22. American Physical Society (APS), 2018.
  ista: Rosenthal EI, Ehrlich NK, Rudner MS, Higginbotham AP, Lehnert KW. 2018. Topological
    phase transition measured in a dissipative metamaterial. Physical Review B. 97(22),
    220301.
  mla: Rosenthal, Eric I., et al. “Topological Phase Transition Measured in a Dissipative
    Metamaterial.” <i>Physical Review B</i>, vol. 97, no. 22, 220301, American Physical
    Society (APS), 2018, doi:<a href="https://doi.org/10.1103/physrevb.97.220301">10.1103/physrevb.97.220301</a>.
  short: E.I. Rosenthal, N.K. Ehrlich, M.S. Rudner, A.P. Higginbotham, K.W. Lehnert,
    Physical Review B 97 (2018).
date_created: 2019-05-03T09:29:49Z
date_published: 2018-06-04T00:00:00Z
date_updated: 2021-01-12T08:07:16Z
day: '04'
doi: 10.1103/physrevb.97.220301
extern: '1'
external_id:
  arxiv:
  - '1802.02243'
fulldoi: https://doi.org/10.1103/physrevb.97.220301
intvolume: '        97'
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1802.02243
month: '06'
oa: 1
oa_version: Preprint
publication: Physical Review B
publication_identifier:
  issn:
  - 2469-9950
  - 2469-9969
publication_status: published
publisher: American Physical Society (APS)
quality_controlled: '1'
status: public
title: Topological phase transition measured in a dissipative metamaterial
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 97
year: '2018'
...
---
_id: '64'
abstract:
- lang: eng
  text: Tropical geometry, an established field in pure mathematics, is a place where
    string theory, mirror symmetry, computational algebra, auction theory, and so
    forth meet and influence one another. In this paper, we report on our discovery
    of a tropical model with self-organized criticality (SOC) behavior. Our model
    is continuous, in contrast to all known models of SOC, and is a certain scaling
    limit of the sandpile model, the first and archetypical model of SOC. We describe
    how our model is related to pattern formation and proportional growth phenomena
    and discuss the dichotomy between continuous and discrete models in several contexts.
    Our aim in this context is to present an idealized tropical toy model (cf. Turing
    reaction-diffusion model), requiring further investigation.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Nikita
  full_name: Kalinin, Nikita
  last_name: Kalinin
- first_name: Aldo
  full_name: Guzmán Sáenz, Aldo
  last_name: Guzmán Sáenz
- first_name: Y
  full_name: Prieto, Y
  last_name: Prieto
- first_name: Mikhail
  full_name: Shkolnikov, Mikhail
  id: 35084A62-F248-11E8-B48F-1D18A9856A87
  last_name: Shkolnikov
  orcid: 0000-0002-4310-178X
- first_name: V
  full_name: Kalinina, V
  last_name: Kalinina
- first_name: Ernesto
  full_name: Lupercio, Ernesto
  last_name: Lupercio
citation:
  ama: Kalinin N, Guzmán Sáenz A, Prieto Y, Shkolnikov M, Kalinina V, Lupercio E.
    Self-organized criticality and pattern emergence through the lens of tropical
    geometry. <i>Proceedings of the National Academy of Sciences of the United States
    of America</i>. 2018;115(35):E8135-E8142. doi:<a href="https://doi.org/10.1073/pnas.1805847115">10.1073/pnas.1805847115</a>
  apa: Kalinin, N., Guzmán Sáenz, A., Prieto, Y., Shkolnikov, M., Kalinina, V., &#38;
    Lupercio, E. (2018). Self-organized criticality and pattern emergence through
    the lens of tropical geometry. <i>Proceedings of the National Academy of Sciences
    of the United States of America</i>. National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.1805847115">https://doi.org/10.1073/pnas.1805847115</a>
  chicago: Kalinin, Nikita, Aldo Guzmán Sáenz, Y Prieto, Mikhail Shkolnikov, V Kalinina,
    and Ernesto Lupercio. “Self-Organized Criticality and Pattern Emergence through
    the Lens of Tropical Geometry.” <i>Proceedings of the National Academy of Sciences
    of the United States of America</i>. National Academy of Sciences, 2018. <a href="https://doi.org/10.1073/pnas.1805847115">https://doi.org/10.1073/pnas.1805847115</a>.
  ieee: N. Kalinin, A. Guzmán Sáenz, Y. Prieto, M. Shkolnikov, V. Kalinina, and E.
    Lupercio, “Self-organized criticality and pattern emergence through the lens of
    tropical geometry,” <i>Proceedings of the National Academy of Sciences of the
    United States of America</i>, vol. 115, no. 35. National Academy of Sciences,
    pp. E8135–E8142, 2018.
  ista: Kalinin N, Guzmán Sáenz A, Prieto Y, Shkolnikov M, Kalinina V, Lupercio E.
    2018. Self-organized criticality and pattern emergence through the lens of tropical
    geometry. Proceedings of the National Academy of Sciences of the United States
    of America. 115(35), E8135–E8142.
  mla: Kalinin, Nikita, et al. “Self-Organized Criticality and Pattern Emergence through
    the Lens of Tropical Geometry.” <i>Proceedings of the National Academy of Sciences
    of the United States of America</i>, vol. 115, no. 35, National Academy of Sciences,
    2018, pp. E8135–42, doi:<a href="https://doi.org/10.1073/pnas.1805847115">10.1073/pnas.1805847115</a>.
  short: N. Kalinin, A. Guzmán Sáenz, Y. Prieto, M. Shkolnikov, V. Kalinina, E. Lupercio,
    Proceedings of the National Academy of Sciences of the United States of America
    115 (2018) E8135–E8142.
date_created: 2018-12-11T11:44:26Z
date_published: 2018-08-28T00:00:00Z
date_updated: 2025-06-03T11:21:16Z
day: '28'
department:
- _id: TaHa
doi: 10.1073/pnas.1805847115
ec_funded: 1
external_id:
  arxiv:
  - '1806.09153'
  isi:
  - '000442861600009'
fulldoi: https://doi.org/10.1073/pnas.1805847115
intvolume: '       115'
isi: 1
issue: '35'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1806.09153
month: '08'
oa: 1
oa_version: Preprint
page: E8135 - E8142
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: Proceedings of the National Academy of Sciences of the United States
  of America
publication_identifier:
  issn:
  - 0027-8424
publication_status: published
publisher: National Academy of Sciences
publist_id: '7990'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Self-organized criticality and pattern emergence through the lens of tropical
  geometry
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 115
year: '2018'
...
---
OA_place: repository
OA_type: green
_id: '19806'
abstract:
- lang: eng
  text: Transition-metal dichalcogenides (TMDs) are renowned for their rich and varied
    bulk properties, while their single-layer variants have become one of the most
    prominent examples of two-dimensional materials beyond graphene. Their disparate
    ground states largely depend on transition metal d-electron-derived electronic
    states, on which the vast majority of attention has been concentrated to date.
    Here, we focus on the chalcogen-derived states. From density-functional theory
    calculations together with spin- and angle-resolved photoemission, we find that
    these generically host a co-existence of type-I and type-II three-dimensional
    bulk Dirac fermions as well as ladders of topological surface states and surface
    resonances. We demonstrate how these naturally arise within a single p-orbital
    manifold as a general consequence of a trigonal crystal field, and as such can
    be expected across a large number of compounds. Already, we demonstrate their
    existence in six separate TMDs, opening routes to tune, and ultimately exploit,
    their topological physics.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: M. S.
  full_name: Bahramy, M. S.
  last_name: Bahramy
- first_name: O. J.
  full_name: Clark, O. J.
  last_name: Clark
- first_name: B.-J.
  full_name: Yang, B.-J.
  last_name: Yang
- first_name: J.
  full_name: Feng, J.
  last_name: Feng
- first_name: L.
  full_name: Bawden, L.
  last_name: Bawden
- first_name: J. M.
  full_name: Riley, J. M.
  last_name: Riley
- first_name: I.
  full_name: Marković, I.
  last_name: Marković
- first_name: F.
  full_name: Mazzola, F.
  last_name: Mazzola
- first_name: Veronika
  full_name: Sunko, Veronika
  id: 23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3
  last_name: Sunko
  orcid: 0000-0003-2724-3523
- first_name: D.
  full_name: Biswas, D.
  last_name: Biswas
- first_name: S. P.
  full_name: Cooil, S. P.
  last_name: Cooil
- first_name: M.
  full_name: Jorge, M.
  last_name: Jorge
- first_name: J. W.
  full_name: Wells, J. W.
  last_name: Wells
- first_name: M.
  full_name: Leandersson, M.
  last_name: Leandersson
- first_name: T.
  full_name: Balasubramanian, T.
  last_name: Balasubramanian
- first_name: J.
  full_name: Fujii, J.
  last_name: Fujii
- first_name: I.
  full_name: Vobornik, I.
  last_name: Vobornik
- first_name: J. E.
  full_name: Rault, J. E.
  last_name: Rault
- first_name: T. K.
  full_name: Kim, T. K.
  last_name: Kim
- first_name: M.
  full_name: Hoesch, M.
  last_name: Hoesch
- first_name: K.
  full_name: Okawa, K.
  last_name: Okawa
- first_name: M.
  full_name: Asakawa, M.
  last_name: Asakawa
- first_name: T.
  full_name: Sasagawa, T.
  last_name: Sasagawa
- first_name: T.
  full_name: Eknapakul, T.
  last_name: Eknapakul
- first_name: W.
  full_name: Meevasana, W.
  last_name: Meevasana
- first_name: P. D. C.
  full_name: King, P. D. C.
  last_name: King
citation:
  ama: Bahramy MS, Clark OJ, Yang B-J, et al. Ubiquitous formation of bulk Dirac cones
    and topological surface states from a single orbital manifold in transition-metal
    dichalcogenides. <i>Nature Materials</i>. 2018;17:21-28. doi:<a href="https://doi.org/10.1038/nmat5031">10.1038/nmat5031</a>
  apa: Bahramy, M. S., Clark, O. J., Yang, B.-J., Feng, J., Bawden, L., Riley, J.
    M., … King, P. D. C. (2018). Ubiquitous formation of bulk Dirac cones and topological
    surface states from a single orbital manifold in transition-metal dichalcogenides.
    <i>Nature Materials</i>. Springer Nature. <a href="https://doi.org/10.1038/nmat5031">https://doi.org/10.1038/nmat5031</a>
  chicago: Bahramy, M. S., O. J. Clark, B.-J. Yang, J. Feng, L. Bawden, J. M. Riley,
    I. Marković, et al. “Ubiquitous Formation of Bulk Dirac Cones and Topological
    Surface States from a Single Orbital Manifold in Transition-Metal Dichalcogenides.”
    <i>Nature Materials</i>. Springer Nature, 2018. <a href="https://doi.org/10.1038/nmat5031">https://doi.org/10.1038/nmat5031</a>.
  ieee: M. S. Bahramy <i>et al.</i>, “Ubiquitous formation of bulk Dirac cones and
    topological surface states from a single orbital manifold in transition-metal
    dichalcogenides,” <i>Nature Materials</i>, vol. 17. Springer Nature, pp. 21–28,
    2018.
  ista: Bahramy MS, Clark OJ, Yang B-J, Feng J, Bawden L, Riley JM, Marković I, Mazzola
    F, Sunko V, Biswas D, Cooil SP, Jorge M, Wells JW, Leandersson M, Balasubramanian
    T, Fujii J, Vobornik I, Rault JE, Kim TK, Hoesch M, Okawa K, Asakawa M, Sasagawa
    T, Eknapakul T, Meevasana W, King PDC. 2018. Ubiquitous formation of bulk Dirac
    cones and topological surface states from a single orbital manifold in transition-metal
    dichalcogenides. Nature Materials. 17, 21–28.
  mla: Bahramy, M. S., et al. “Ubiquitous Formation of Bulk Dirac Cones and Topological
    Surface States from a Single Orbital Manifold in Transition-Metal Dichalcogenides.”
    <i>Nature Materials</i>, vol. 17, Springer Nature, 2018, pp. 21–28, doi:<a href="https://doi.org/10.1038/nmat5031">10.1038/nmat5031</a>.
  short: M.S. Bahramy, O.J. Clark, B.-J. Yang, J. Feng, L. Bawden, J.M. Riley, I.
    Marković, F. Mazzola, V. Sunko, D. Biswas, S.P. Cooil, M. Jorge, J.W. Wells, M.
    Leandersson, T. Balasubramanian, J. Fujii, I. Vobornik, J.E. Rault, T.K. Kim,
    M. Hoesch, K. Okawa, M. Asakawa, T. Sasagawa, T. Eknapakul, W. Meevasana, P.D.C.
    King, Nature Materials 17 (2018) 21–28.
date_created: 2025-06-10T09:11:05Z
date_published: 2018-01-01T00:00:00Z
date_updated: 2025-06-10T11:12:41Z
day: '01'
doi: 10.1038/nmat5031
extern: '1'
external_id:
  arxiv:
  - '1702.08177'
  pmid:
  - '29180775'
fulldoi: https://doi.org/10.1038/nmat5031
intvolume: '        17'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.1702.08177
month: '01'
oa: 1
oa_version: Preprint
page: 21-28
pmid: 1
publication: Nature Materials
publication_identifier:
  eissn:
  - 1476-4660
  issn:
  - 1476-1122
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Ubiquitous formation of bulk Dirac cones and topological surface states from
  a single orbital manifold in transition-metal dichalcogenides
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2018'
...
---
OA_place: publisher
OA_type: gold
_id: '19808'
abstract:
- lang: eng
  text: The single-band, quasi-two dimensional metals PdCoO2 and PtCoO2 have recently
    come to prominence because of their extremely long mean free paths, which establish
    them as some of the most electronically pure materials known, and as potential
    hosts of previously unobservable regimes of electronic transport. To fully establish
    their magnetotransport properties, we have studied the magnetoresistance and Hall
    effect in bulk single crystals to which electrical contacts have been made with
    high precision using focused ion beam machining. We observe a strong temperature
    dependence of the Hall resistivity in small applied fields, linked to a large
    violation of Kohler’s rule in the magnetoresistance. We discuss the extent to
    which these observations can be accounted for by standard transport theory.
article_number: '66'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Nabhanila
  full_name: Nandi, Nabhanila
  last_name: Nandi
- first_name: Thomas
  full_name: Scaffidi, Thomas
  last_name: Scaffidi
- first_name: Pallavi
  full_name: Kushwaha, Pallavi
  last_name: Kushwaha
- first_name: Seunghyun
  full_name: Khim, Seunghyun
  last_name: Khim
- first_name: Mark E.
  full_name: Barber, Mark E.
  last_name: Barber
- first_name: Veronika
  full_name: Sunko, Veronika
  id: 23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3
  last_name: Sunko
  orcid: 0000-0003-2724-3523
- first_name: Federico
  full_name: Mazzola, Federico
  last_name: Mazzola
- first_name: Philip D. C.
  full_name: King, Philip D. C.
  last_name: King
- first_name: Helge
  full_name: Rosner, Helge
  last_name: Rosner
- first_name: Philip J. W.
  full_name: Moll, Philip J. W.
  last_name: Moll
- first_name: Markus
  full_name: König, Markus
  last_name: König
- first_name: Joel E.
  full_name: Moore, Joel E.
  last_name: Moore
- first_name: Sean
  full_name: Hartnoll, Sean
  last_name: Hartnoll
- first_name: Andrew P.
  full_name: Mackenzie, Andrew P.
  last_name: Mackenzie
citation:
  ama: Nandi N, Scaffidi T, Kushwaha P, et al. Unconventional magneto-transport in
    ultrapure PdCoO2 and PtCoO2. <i>npj Quantum Materials</i>. 2018;3. doi:<a href="https://doi.org/10.1038/s41535-018-0138-8">10.1038/s41535-018-0138-8</a>
  apa: Nandi, N., Scaffidi, T., Kushwaha, P., Khim, S., Barber, M. E., Sunko, V.,
    … Mackenzie, A. P. (2018). Unconventional magneto-transport in ultrapure PdCoO2
    and PtCoO2. <i>Npj Quantum Materials</i>. Springer Nature. <a href="https://doi.org/10.1038/s41535-018-0138-8">https://doi.org/10.1038/s41535-018-0138-8</a>
  chicago: Nandi, Nabhanila, Thomas Scaffidi, Pallavi Kushwaha, Seunghyun Khim, Mark
    E. Barber, Veronika Sunko, Federico Mazzola, et al. “Unconventional Magneto-Transport
    in Ultrapure PdCoO2 and PtCoO2.” <i>Npj Quantum Materials</i>. Springer Nature,
    2018. <a href="https://doi.org/10.1038/s41535-018-0138-8">https://doi.org/10.1038/s41535-018-0138-8</a>.
  ieee: N. Nandi <i>et al.</i>, “Unconventional magneto-transport in ultrapure PdCoO2
    and PtCoO2,” <i>npj Quantum Materials</i>, vol. 3. Springer Nature, 2018.
  ista: Nandi N, Scaffidi T, Kushwaha P, Khim S, Barber ME, Sunko V, Mazzola F, King
    PDC, Rosner H, Moll PJW, König M, Moore JE, Hartnoll S, Mackenzie AP. 2018. Unconventional
    magneto-transport in ultrapure PdCoO2 and PtCoO2. npj Quantum Materials. 3, 66.
  mla: Nandi, Nabhanila, et al. “Unconventional Magneto-Transport in Ultrapure PdCoO2
    and PtCoO2.” <i>Npj Quantum Materials</i>, vol. 3, 66, Springer Nature, 2018,
    doi:<a href="https://doi.org/10.1038/s41535-018-0138-8">10.1038/s41535-018-0138-8</a>.
  short: N. Nandi, T. Scaffidi, P. Kushwaha, S. Khim, M.E. Barber, V. Sunko, F. Mazzola,
    P.D.C. King, H. Rosner, P.J.W. Moll, M. König, J.E. Moore, S. Hartnoll, A.P. Mackenzie,
    Npj Quantum Materials 3 (2018).
date_created: 2025-06-10T09:12:15Z
date_published: 2018-12-18T00:00:00Z
date_updated: 2025-06-10T11:39:41Z
day: '18'
doi: 10.1038/s41535-018-0138-8
extern: '1'
external_id:
  arxiv:
  - '1804.01896'
fulldoi: https://doi.org/10.1038/s41535-018-0138-8
has_accepted_license: '1'
intvolume: '         3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1038/s41535-018-0138-8
month: '12'
oa: 1
oa_version: Published Version
publication: npj Quantum Materials
publication_identifier:
  issn:
  - 2397-4648
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Unconventional magneto-transport in ultrapure PdCoO2 and PtCoO2
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2018'
...
---
OA_place: repository
OA_type: green
_id: '19813'
abstract:
- lang: eng
  text: "We study the low-energy surface electronic structure of the transition-metal
    dichalcogenide superconductor PdTe2 by spin- and angle-resolved photoemission,
    scanning tunneling microscopy, and density-functional theory-based supercell calculations.
    Comparing PdTe2 with its sister compound PtSe2, we demonstrate how enhanced interlayer
    hopping in the Te-based material drives a band inversion within the antibonding
    \U0001D45D-orbital manifold well above the Fermi level. We show how this mediates
    spin-polarized topological surface states which form rich multivalley Fermi surfaces
    with complex spin textures. Scanning tunneling spectroscopy reveals type-II superconductivity
    at the surface, and moreover shows no evidence for an unconventional component
    of its superconducting order parameter, despite the presence of topological surface
    states."
article_number: '156401'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: O. J.
  full_name: Clark, O. J.
  last_name: Clark
- first_name: M. J.
  full_name: Neat, M. J.
  last_name: Neat
- first_name: K.
  full_name: Okawa, K.
  last_name: Okawa
- first_name: L.
  full_name: Bawden, L.
  last_name: Bawden
- first_name: I.
  full_name: Marković, I.
  last_name: Marković
- first_name: F.
  full_name: Mazzola, F.
  last_name: Mazzola
- first_name: J.
  full_name: Feng, J.
  last_name: Feng
- first_name: Veronika
  full_name: Sunko, Veronika
  id: 23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3
  last_name: Sunko
  orcid: 0000-0003-2724-3523
- first_name: J. M.
  full_name: Riley, J. M.
  last_name: Riley
- first_name: W.
  full_name: Meevasana, W.
  last_name: Meevasana
- first_name: J.
  full_name: Fujii, J.
  last_name: Fujii
- first_name: I.
  full_name: Vobornik, I.
  last_name: Vobornik
- first_name: T. K.
  full_name: Kim, T. K.
  last_name: Kim
- first_name: M.
  full_name: Hoesch, M.
  last_name: Hoesch
- first_name: T.
  full_name: Sasagawa, T.
  last_name: Sasagawa
- first_name: P.
  full_name: Wahl, P.
  last_name: Wahl
- first_name: M. S.
  full_name: Bahramy, M. S.
  last_name: Bahramy
- first_name: P. D. C.
  full_name: King, P. D. C.
  last_name: King
citation:
  ama: Clark OJ, Neat MJ, Okawa K, et al. Fermiology and superconductivity of topological
    surface states in PdTe2. <i>Physical Review Letters</i>. 2018;120(15). doi:<a
    href="https://doi.org/10.1103/physrevlett.120.156401">10.1103/physrevlett.120.156401</a>
  apa: Clark, O. J., Neat, M. J., Okawa, K., Bawden, L., Marković, I., Mazzola, F.,
    … King, P. D. C. (2018). Fermiology and superconductivity of topological surface
    states in PdTe2. <i>Physical Review Letters</i>. American Physical Society. <a
    href="https://doi.org/10.1103/physrevlett.120.156401">https://doi.org/10.1103/physrevlett.120.156401</a>
  chicago: Clark, O. J., M. J. Neat, K. Okawa, L. Bawden, I. Marković, F. Mazzola,
    J. Feng, et al. “Fermiology and Superconductivity of Topological Surface States
    in PdTe2.” <i>Physical Review Letters</i>. American Physical Society, 2018. <a
    href="https://doi.org/10.1103/physrevlett.120.156401">https://doi.org/10.1103/physrevlett.120.156401</a>.
  ieee: O. J. Clark <i>et al.</i>, “Fermiology and superconductivity of topological
    surface states in PdTe2,” <i>Physical Review Letters</i>, vol. 120, no. 15. American
    Physical Society, 2018.
  ista: Clark OJ, Neat MJ, Okawa K, Bawden L, Marković I, Mazzola F, Feng J, Sunko
    V, Riley JM, Meevasana W, Fujii J, Vobornik I, Kim TK, Hoesch M, Sasagawa T, Wahl
    P, Bahramy MS, King PDC. 2018. Fermiology and superconductivity of topological
    surface states in PdTe2. Physical Review Letters. 120(15), 156401.
  mla: Clark, O. J., et al. “Fermiology and Superconductivity of Topological Surface
    States in PdTe2.” <i>Physical Review Letters</i>, vol. 120, no. 15, 156401, American
    Physical Society, 2018, doi:<a href="https://doi.org/10.1103/physrevlett.120.156401">10.1103/physrevlett.120.156401</a>.
  short: O.J. Clark, M.J. Neat, K. Okawa, L. Bawden, I. Marković, F. Mazzola, J. Feng,
    V. Sunko, J.M. Riley, W. Meevasana, J. Fujii, I. Vobornik, T.K. Kim, M. Hoesch,
    T. Sasagawa, P. Wahl, M.S. Bahramy, P.D.C. King, Physical Review Letters 120 (2018).
date_created: 2025-06-10T09:14:51Z
date_published: 2018-04-09T00:00:00Z
date_updated: 2025-06-10T12:16:08Z
day: '09'
doi: 10.1103/physrevlett.120.156401
extern: '1'
external_id:
  arxiv:
  - '1712.04184'
  pmid:
  - '29756894'
fulldoi: https://doi.org/10.1103/physrevlett.120.156401
intvolume: '       120'
issue: '15'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.1712.04184
month: '04'
oa: 1
oa_version: Preprint
pmid: 1
publication: Physical Review Letters
publication_identifier:
  eissn:
  - 1079-7114
  issn:
  - 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fermiology and superconductivity of topological surface states in PdTe2
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 120
year: '2018'
...
---
OA_place: repository
OA_type: green
_id: '19819'
abstract:
- lang: eng
  text: The ability to modulate the collective properties of correlated electron systems
    at their interfaces and surfaces underpins the burgeoning field of “designer”
    quantum materials. Here, we show how an electronic reconstruction driven by surface
    polarity mediates a Stoner-like magnetic instability to itinerant ferromagnetism
    at the Pd-terminated surface of the nonmagnetic delafossite oxide metal PdCoO2.
    Combining angle-resolved photoemission spectroscopy and density-functional theory
    calculations, we show how this leads to a rich multiband surface electronic structure.
    We find similar surface state dispersions in PdCrO2, suggesting surface ferromagnetism
    persists in this sister compound despite its bulk antiferromagnetic order.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Federico
  full_name: Mazzola, Federico
  last_name: Mazzola
- first_name: Veronika
  full_name: Sunko, Veronika
  id: 23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3
  last_name: Sunko
  orcid: 0000-0003-2724-3523
- first_name: Seunghyun
  full_name: Khim, Seunghyun
  last_name: Khim
- first_name: Helge
  full_name: Rosner, Helge
  last_name: Rosner
- first_name: Pallavi
  full_name: Kushwaha, Pallavi
  last_name: Kushwaha
- first_name: Oliver J.
  full_name: Clark, Oliver J.
  last_name: Clark
- first_name: Lewis
  full_name: Bawden, Lewis
  last_name: Bawden
- first_name: Igor
  full_name: Marković, Igor
  last_name: Marković
- first_name: Timur K.
  full_name: Kim, Timur K.
  last_name: Kim
- first_name: Moritz
  full_name: Hoesch, Moritz
  last_name: Hoesch
- first_name: Andrew P.
  full_name: Mackenzie, Andrew P.
  last_name: Mackenzie
- first_name: Phil D. C.
  full_name: King, Phil D. C.
  last_name: King
citation:
  ama: Mazzola F, Sunko V, Khim S, et al. Itinerant ferromagnetism of the Pd-terminated
    polar surface of PdCoO2. <i>Proceedings of the National Academy of Sciences</i>.
    2018;115(51):12956-12960. doi:<a href="https://doi.org/10.1073/pnas.1811873115">10.1073/pnas.1811873115</a>
  apa: Mazzola, F., Sunko, V., Khim, S., Rosner, H., Kushwaha, P., Clark, O. J., …
    King, P. D. C. (2018). Itinerant ferromagnetism of the Pd-terminated polar surface
    of PdCoO2. <i>Proceedings of the National Academy of Sciences</i>. National Academy
    of Sciences. <a href="https://doi.org/10.1073/pnas.1811873115">https://doi.org/10.1073/pnas.1811873115</a>
  chicago: Mazzola, Federico, Veronika Sunko, Seunghyun Khim, Helge Rosner, Pallavi
    Kushwaha, Oliver J. Clark, Lewis Bawden, et al. “Itinerant Ferromagnetism of the
    Pd-Terminated Polar Surface of PdCoO2.” <i>Proceedings of the National Academy
    of Sciences</i>. National Academy of Sciences, 2018. <a href="https://doi.org/10.1073/pnas.1811873115">https://doi.org/10.1073/pnas.1811873115</a>.
  ieee: F. Mazzola <i>et al.</i>, “Itinerant ferromagnetism of the Pd-terminated polar
    surface of PdCoO2,” <i>Proceedings of the National Academy of Sciences</i>, vol.
    115, no. 51. National Academy of Sciences, pp. 12956–12960, 2018.
  ista: Mazzola F, Sunko V, Khim S, Rosner H, Kushwaha P, Clark OJ, Bawden L, Marković
    I, Kim TK, Hoesch M, Mackenzie AP, King PDC. 2018. Itinerant ferromagnetism of
    the Pd-terminated polar surface of PdCoO2. Proceedings of the National Academy
    of Sciences. 115(51), 12956–12960.
  mla: Mazzola, Federico, et al. “Itinerant Ferromagnetism of the Pd-Terminated Polar
    Surface of PdCoO2.” <i>Proceedings of the National Academy of Sciences</i>, vol.
    115, no. 51, National Academy of Sciences, 2018, pp. 12956–60, doi:<a href="https://doi.org/10.1073/pnas.1811873115">10.1073/pnas.1811873115</a>.
  short: F. Mazzola, V. Sunko, S. Khim, H. Rosner, P. Kushwaha, O.J. Clark, L. Bawden,
    I. Marković, T.K. Kim, M. Hoesch, A.P. Mackenzie, P.D.C. King, Proceedings of
    the National Academy of Sciences 115 (2018) 12956–12960.
date_created: 2025-06-10T09:19:14Z
date_published: 2018-12-04T00:00:00Z
date_updated: 2025-06-10T12:40:00Z
day: '04'
doi: 10.1073/pnas.1811873115
extern: '1'
external_id:
  arxiv:
  - '1710.05392'
  pmid:
  - '30514820'
fulldoi: https://doi.org/10.1073/pnas.1811873115
intvolume: '       115'
issue: '51'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.1710.05392
month: '12'
oa: 1
oa_version: Preprint
page: 12956-12960
pmid: 1
publication: Proceedings of the National Academy of Sciences
publication_identifier:
  eissn:
  - 1091-6490
  issn:
  - 0027-8424
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Itinerant ferromagnetism of the Pd-terminated polar surface of PdCoO2
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 115
year: '2018'
...
---
_id: '199'
abstract:
- lang: eng
  text: Sex-biased genes are central to the study of sexual selection, sexual antagonism,
    and sex chromosome evolution. We describe a comprehensive de novo assembled transcriptome
    in the common frog Rana temporaria based on five developmental stages and three
    adult tissues from both sexes, obtained from a population with karyotypically
    homomorphic but genetically differentiated sex chromosomes. This allows the study
    of sex-biased gene expression throughout development, and its effect on the rate
    of gene evolution while accounting for pleiotropic expression, which is known
    to negatively correlate with the evolutionary rate. Overall, sex-biased genes
    had little overlap among developmental stages and adult tissues. Late developmental
    stages and gonad tissues had the highest numbers of stage-or tissue-specific genes.
    We find that pleiotropic gene expression is a better predictor than sex bias for
    the evolutionary rate of genes, though it often interacts with sex bias. Although
    genetically differentiated, the sex chromosomes were not enriched in sex-biased
    genes, possibly due to a very recent arrest of XY recombination. These results
    extend our understanding of the developmental dynamics, tissue specificity, and
    genomic localization of sex-biased genes.
article_number: '294'
article_processing_charge: No
author:
- first_name: Wen
  full_name: Ma, Wen
  last_name: Ma
- first_name: Paris
  full_name: Veltsos, Paris
  last_name: Veltsos
- first_name: Melissa A
  full_name: Toups, Melissa A
  id: 4E099E4E-F248-11E8-B48F-1D18A9856A87
  last_name: Toups
  orcid: 0000-0002-9752-7380
- first_name: Nicolas
  full_name: Rodrigues, Nicolas
  last_name: Rodrigues
- first_name: Roberto
  full_name: Sermier, Roberto
  last_name: Sermier
- first_name: Daniel
  full_name: Jeffries, Daniel
  last_name: Jeffries
- first_name: Nicolas
  full_name: Perrin, Nicolas
  last_name: Perrin
citation:
  ama: Ma W, Veltsos P, Toups MA, et al. Tissue specificity and dynamics of sex biased
    gene expression in a common frog population with differentiated, yet homomorphic,
    sex chromosomes. <i>Genes</i>. 2018;9(6). doi:<a href="https://doi.org/10.3390/genes9060294">10.3390/genes9060294</a>
  apa: Ma, W., Veltsos, P., Toups, M. A., Rodrigues, N., Sermier, R., Jeffries, D.,
    &#38; Perrin, N. (2018). Tissue specificity and dynamics of sex biased gene expression
    in a common frog population with differentiated, yet homomorphic, sex chromosomes.
    <i>Genes</i>. MDPI. <a href="https://doi.org/10.3390/genes9060294">https://doi.org/10.3390/genes9060294</a>
  chicago: Ma, Wen, Paris Veltsos, Melissa A Toups, Nicolas Rodrigues, Roberto Sermier,
    Daniel Jeffries, and Nicolas Perrin. “Tissue Specificity and Dynamics of Sex Biased
    Gene Expression in a Common Frog Population with Differentiated, yet Homomorphic,
    Sex Chromosomes.” <i>Genes</i>. MDPI, 2018. <a href="https://doi.org/10.3390/genes9060294">https://doi.org/10.3390/genes9060294</a>.
  ieee: W. Ma <i>et al.</i>, “Tissue specificity and dynamics of sex biased gene expression
    in a common frog population with differentiated, yet homomorphic, sex chromosomes,”
    <i>Genes</i>, vol. 9, no. 6. MDPI, 2018.
  ista: Ma W, Veltsos P, Toups MA, Rodrigues N, Sermier R, Jeffries D, Perrin N. 2018.
    Tissue specificity and dynamics of sex biased gene expression in a common frog
    population with differentiated, yet homomorphic, sex chromosomes. Genes. 9(6),
    294.
  mla: Ma, Wen, et al. “Tissue Specificity and Dynamics of Sex Biased Gene Expression
    in a Common Frog Population with Differentiated, yet Homomorphic, Sex Chromosomes.”
    <i>Genes</i>, vol. 9, no. 6, 294, MDPI, 2018, doi:<a href="https://doi.org/10.3390/genes9060294">10.3390/genes9060294</a>.
  short: W. Ma, P. Veltsos, M.A. Toups, N. Rodrigues, R. Sermier, D. Jeffries, N.
    Perrin, Genes 9 (2018).
date_created: 2018-12-11T11:45:09Z
date_published: 2018-06-12T00:00:00Z
date_updated: 2024-12-11T13:13:35Z
day: '12'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.3390/genes9060294
external_id:
  isi:
  - '000436494200026'
file:
- access_level: open_access
  checksum: 423069beb1cd3cdd25bf3f464b38f1d7
  content_type: application/pdf
  creator: dernst
  date_created: 2019-02-01T07:52:28Z
  date_updated: 2020-07-14T12:45:22Z
  file_id: '5905'
  file_name: 2018_Genes_Ma.pdf
  file_size: 3985796
  relation: main_file
file_date_updated: 2020-07-14T12:45:22Z
fulldoi: https://doi.org/10.3390/genes9060294
has_accepted_license: '1'
intvolume: '         9'
isi: 1
issue: '6'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
publication: Genes
publication_status: published
publisher: MDPI
publist_id: '7714'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tissue specificity and dynamics of sex biased gene expression in a common frog
  population with differentiated, yet homomorphic, sex chromosomes
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2018'
...
---
_id: '20'
abstract:
- lang: eng
  text: 'Background: Norepinephrine (NE) signaling has a key role in white adipose
    tissue (WAT) functions, including lipolysis, free fatty acid liberation and, under
    certain conditions, conversion of white into brite (brown-in-white) adipocytes.
    However, acute effects of NE stimulation have not been described at the transcriptional
    network level. Results: We used RNA-seq to uncover a broad transcriptional response.
    The inference of protein-protein and protein-DNA interaction networks allowed
    us to identify a set of immediate-early genes (IEGs) with high betweenness, validating
    our approach and suggesting a hierarchical control of transcriptional regulation.
    In addition, we identified a transcriptional regulatory network with IEGs as master
    regulators, including HSF1 and NFIL3 as novel NE-induced IEG candidates. Moreover,
    a functional enrichment analysis and gene clustering into functional modules suggest
    a crosstalk between metabolic, signaling, and immune responses. Conclusions: Altogether,
    our network biology approach explores for the first time the immediate-early systems
    level response of human adipocytes to acute sympathetic activation, thereby providing
    a first network basis of early cell fate programs and crosstalks between metabolic
    and transcriptional networks required for proper WAT function.'
acknowledgement: This work was funded by the German Centre for Diabetes Research (DZD)
  and the Austrian Science Fund (FWF, P25729-B19).
article_processing_charge: No
article_type: original
author:
- first_name: Juan
  full_name: Higareda Almaraz, Juan
  last_name: Higareda Almaraz
- first_name: Michael
  full_name: Karbiener, Michael
  last_name: Karbiener
- first_name: Maude
  full_name: Giroud, Maude
  last_name: Giroud
- first_name: Florian
  full_name: Pauler, Florian
  id: 48EA0138-F248-11E8-B48F-1D18A9856A87
  last_name: Pauler
  orcid: 0000-0002-7462-0048
- first_name: Teresa
  full_name: Gerhalter, Teresa
  last_name: Gerhalter
- first_name: Stephan
  full_name: Herzig, Stephan
  last_name: Herzig
- first_name: Marcel
  full_name: Scheideler, Marcel
  last_name: Scheideler
citation:
  ama: Higareda Almaraz J, Karbiener M, Giroud M, et al. Norepinephrine triggers an
    immediate-early regulatory network response in primary human white adipocytes.
    <i>BMC Genomics</i>. 2018;19(1). doi:<a href="https://doi.org/10.1186/s12864-018-5173-0">10.1186/s12864-018-5173-0</a>
  apa: Higareda Almaraz, J., Karbiener, M., Giroud, M., Pauler, F., Gerhalter, T.,
    Herzig, S., &#38; Scheideler, M. (2018). Norepinephrine triggers an immediate-early
    regulatory network response in primary human white adipocytes. <i>BMC Genomics</i>.
    BioMed Central. <a href="https://doi.org/10.1186/s12864-018-5173-0">https://doi.org/10.1186/s12864-018-5173-0</a>
  chicago: Higareda Almaraz, Juan, Michael Karbiener, Maude Giroud, Florian Pauler,
    Teresa Gerhalter, Stephan Herzig, and Marcel Scheideler. “Norepinephrine Triggers
    an Immediate-Early Regulatory Network Response in Primary Human White Adipocytes.”
    <i>BMC Genomics</i>. BioMed Central, 2018. <a href="https://doi.org/10.1186/s12864-018-5173-0">https://doi.org/10.1186/s12864-018-5173-0</a>.
  ieee: J. Higareda Almaraz <i>et al.</i>, “Norepinephrine triggers an immediate-early
    regulatory network response in primary human white adipocytes,” <i>BMC Genomics</i>,
    vol. 19, no. 1. BioMed Central, 2018.
  ista: Higareda Almaraz J, Karbiener M, Giroud M, Pauler F, Gerhalter T, Herzig S,
    Scheideler M. 2018. Norepinephrine triggers an immediate-early regulatory network
    response in primary human white adipocytes. BMC Genomics. 19(1).
  mla: Higareda Almaraz, Juan, et al. “Norepinephrine Triggers an Immediate-Early
    Regulatory Network Response in Primary Human White Adipocytes.” <i>BMC Genomics</i>,
    vol. 19, no. 1, BioMed Central, 2018, doi:<a href="https://doi.org/10.1186/s12864-018-5173-0">10.1186/s12864-018-5173-0</a>.
  short: J. Higareda Almaraz, M. Karbiener, M. Giroud, F. Pauler, T. Gerhalter, S.
    Herzig, M. Scheideler, BMC Genomics 19 (2018).
date_created: 2018-12-11T11:44:12Z
date_published: 2018-11-03T00:00:00Z
date_updated: 2023-09-13T09:10:47Z
day: '03'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1186/s12864-018-5173-0
external_id:
  isi:
  - '000450976700002'
file:
- access_level: open_access
  checksum: a56516e734dab589dc7f3e1915973b4d
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T14:52:57Z
  date_updated: 2020-07-14T12:45:23Z
  file_id: '5712'
  file_name: 2018_BMCGenomics_Higareda.pdf
  file_size: 4629784
  relation: main_file
file_date_updated: 2020-07-14T12:45:23Z
fulldoi: https://doi.org/10.1186/s12864-018-5173-0
has_accepted_license: '1'
intvolume: '        19'
isi: 1
issue: '1'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: BMC Genomics
publication_identifier:
  issn:
  - 1471-2164
publication_status: published
publisher: BioMed Central
publist_id: '8035'
quality_controlled: '1'
related_material:
  record:
  - id: '9807'
    relation: research_data
    status: public
  - id: '9808'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Norepinephrine triggers an immediate-early regulatory network response in primary
  human white adipocytes
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 19
year: '2018'
...
---
OA_place: publisher
_id: '200'
abstract:
- lang: eng
  text: This thesis is concerned with the inference of current population structure
    based on geo-referenced genetic data. The underlying idea is that population structure
    affects its spatial genetic structure. Therefore, genotype information can be
    utilized to estimate important demographic parameters such as migration rates.
    These indirect estimates of population structure have become very attractive,
    as genotype data is now widely available. However, there also has been much concern
    about these approaches. Importantly, genetic structure can be influenced by many
    complex patterns, which often cannot be disentangled. Moreover, many methods merely
    fit heuristic patterns of genetic structure, and do not build upon population
    genetics theory. Here, I describe two novel inference methods that address these
    shortcomings. In Chapter 2, I introduce an inference scheme based on a new type
    of signal, identity by descent (IBD) blocks. Recently, it has become feasible
    to detect such long blocks of genome shared between pairs of samples. These blocks
    are direct traces of recent coalescence events. As such, they contain ample signal
    for inferring recent demography. I examine sharing of IBD blocks in two-dimensional
    populations with local migration. Using a diffusion approximation, I derive formulas
    for an isolation by distance pattern of long IBD blocks and show that sharing
    of long IBD blocks approaches rapid exponential decay for growing sample distance.
    I describe an inference scheme based on these results. It can robustly estimate
    the dispersal rate and population density, which is demonstrated on simulated
    data. I also show an application to estimate mean migration and the rate of recent
    population growth within Eastern Europe. Chapter 3 is about a novel method to
    estimate barriers to gene flow in a two dimensional population. This inference
    scheme utilizes geographically localized allele frequency fluctuations - a classical
    isolation by distance signal. The strength of these local fluctuations increases
    on average next to a barrier, and there is less correlation across it. I again
    use a framework of diffusion of ancestral lineages to model this effect, and provide
    an efficient numerical implementation to fit the results to geo-referenced biallelic
    SNP data. This inference scheme is able to robustly estimate strong barriers to
    gene flow, as tests on simulated data confirm.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Harald
  full_name: Ringbauer, Harald
  id: 417FCFF4-F248-11E8-B48F-1D18A9856A87
  last_name: Ringbauer
  orcid: 0000-0002-4884-9682
citation:
  ama: Ringbauer H. Inferring recent demography from spatial genetic structure. 2018.
    doi:<a href="https://doi.org/10.15479/AT:ISTA:th_963">10.15479/AT:ISTA:th_963</a>
  apa: Ringbauer, H. (2018). <i>Inferring recent demography from spatial genetic structure</i>.
    Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:th_963">https://doi.org/10.15479/AT:ISTA:th_963</a>
  chicago: Ringbauer, Harald. “Inferring Recent Demography from Spatial Genetic Structure.”
    Institute of Science and Technology Austria, 2018. <a href="https://doi.org/10.15479/AT:ISTA:th_963">https://doi.org/10.15479/AT:ISTA:th_963</a>.
  ieee: H. Ringbauer, “Inferring recent demography from spatial genetic structure,”
    Institute of Science and Technology Austria, 2018.
  ista: Ringbauer H. 2018. Inferring recent demography from spatial genetic structure.
    Institute of Science and Technology Austria.
  mla: Ringbauer, Harald. <i>Inferring Recent Demography from Spatial Genetic Structure</i>.
    Institute of Science and Technology Austria, 2018, doi:<a href="https://doi.org/10.15479/AT:ISTA:th_963">10.15479/AT:ISTA:th_963</a>.
  short: H. Ringbauer, Inferring Recent Demography from Spatial Genetic Structure,
    Institute of Science and Technology Austria, 2018.
corr_author: '1'
date_created: 2018-12-11T11:45:10Z
date_published: 2018-02-21T00:00:00Z
date_updated: 2026-04-08T14:06:37Z
day: '21'
ddc:
- '576'
degree_awarded: PhD
department:
- _id: NiBa
doi: 10.15479/AT:ISTA:th_963
file:
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  file_id: '6224'
  file_name: 2018_thesis_ringbauer_source.zip
  file_size: 113365
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file_date_updated: 2020-07-14T12:45:23Z
fulldoi: https://doi.org/10.15479/AT:ISTA:th_963
has_accepted_license: '1'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: '146'
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '7713'
pubrep_id: '963'
related_material:
  record:
  - id: '563'
    relation: part_of_dissertation
    status: public
  - id: '1074'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
title: Inferring recent demography from spatial genetic structure
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2018'
...
---
_id: '2015'
abstract:
- lang: eng
  text: We consider the problem of learning a Bayesian network or directed acyclic
    graph model from observational data. A number of constraint‐based, score‐based
    and hybrid algorithms have been developed for this purpose. Statistical consistency
    guarantees of these algorithms rely on the faithfulness assumption, which has
    been shown to be restrictive especially for graphs with cycles in the skeleton.
    We here propose the sparsest permutation (SP) algorithm, showing that learning
    Bayesian networks is possible under strictly weaker assumptions than faithfulness.
    This comes at a computational price, thereby indicating a statistical‐computational
    trade‐off for causal inference algorithms. In the Gaussian noiseless setting,
    we prove that the SP algorithm boils down to finding the permutation of the variables
    with the sparsest Cholesky decomposition of the inverse covariance matrix, which
    is equivalent to ℓ0‐penalized maximum likelihood estimation. We end with a simulation
    study showing that in line with the proven stronger consistency guarantees, and
    the SP algorithm compares favourably to standard causal inference algorithms in
    terms of accuracy for a given sample size.
article_number: e183
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Garvesh
  full_name: Raskutti, Garvesh
  last_name: Raskutti
- first_name: Caroline
  full_name: Uhler, Caroline
  id: 49ADD78E-F248-11E8-B48F-1D18A9856A87
  last_name: Uhler
  orcid: 0000-0002-7008-0216
citation:
  ama: Raskutti G, Uhler C. Learning directed acyclic graphs based on sparsest permutations.
    <i>STAT</i>. 2018;7(1). doi:<a href="https://doi.org/10.1002/sta4.183">10.1002/sta4.183</a>
  apa: Raskutti, G., &#38; Uhler, C. (2018). Learning directed acyclic graphs based
    on sparsest permutations. <i>STAT</i>. Wiley. <a href="https://doi.org/10.1002/sta4.183">https://doi.org/10.1002/sta4.183</a>
  chicago: Raskutti, Garvesh, and Caroline Uhler. “Learning Directed Acyclic Graphs
    Based on Sparsest Permutations.” <i>STAT</i>. Wiley, 2018. <a href="https://doi.org/10.1002/sta4.183">https://doi.org/10.1002/sta4.183</a>.
  ieee: G. Raskutti and C. Uhler, “Learning directed acyclic graphs based on sparsest
    permutations,” <i>STAT</i>, vol. 7, no. 1. Wiley, 2018.
  ista: Raskutti G, Uhler C. 2018. Learning directed acyclic graphs based on sparsest
    permutations. STAT. 7(1), e183.
  mla: Raskutti, Garvesh, and Caroline Uhler. “Learning Directed Acyclic Graphs Based
    on Sparsest Permutations.” <i>STAT</i>, vol. 7, no. 1, e183, Wiley, 2018, doi:<a
    href="https://doi.org/10.1002/sta4.183">10.1002/sta4.183</a>.
  short: G. Raskutti, C. Uhler, STAT 7 (2018).
date_created: 2018-12-11T11:55:13Z
date_published: 2018-04-17T00:00:00Z
date_updated: 2021-01-12T06:54:44Z
day: '17'
doi: 10.1002/sta4.183
extern: '1'
external_id:
  arxiv:
  - '1307.0366'
fulldoi: https://doi.org/10.1002/sta4.183
intvolume: '         7'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/1307.0366
month: '04'
oa: 1
oa_version: Preprint
publication: STAT
publication_status: published
publisher: Wiley
publist_id: '5061'
quality_controlled: '1'
status: public
title: Learning directed acyclic graphs based on sparsest permutations
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2018'
...
---
OA_place: repository
OA_type: green
_id: '203'
abstract:
- lang: eng
  text: Asymmetric auxin distribution is instrumental for the differential growth
    that causes organ bending on tropic stimuli and curvatures during plant development.
    Local differences in auxin concentrations are achieved mainly by polarized cellular
    distribution of PIN auxin transporters, but whether other mechanisms involving
    auxin homeostasis are also relevant for the formation of auxin gradients is not
    clear. Here we show that auxin methylation is required for asymmetric auxin distribution
    across the hypocotyl, particularly during its response to gravity. We found that
    loss-of-function mutants in Arabidopsis IAA CARBOXYL METHYLTRANSFERASE1 (IAMT1)
    prematurely unfold the apical hook, and that their hypocotyls are impaired in
    gravitropic reorientation. This defect is linked to an auxin-dependent increase
    in PIN gene expression, leading to an increased polar auxin transport and lack
    of asymmetric distribution of PIN3 in the iamt1 mutant. Gravitropic reorientation
    in the iamt1 mutant could be restored with either endodermis-specific expression
    of IAMT1 or partial inhibition of polar auxin transport, which also results in
    normal PIN gene expression levels. We propose that IAA methylation is necessary
    in gravity-sensing cells to restrict polar auxin transport within the range of
    auxin levels that allow for differential responses.
article_processing_charge: No
article_type: original
author:
- first_name: Mohamad
  full_name: Abbas, Mohamad
  id: 47E8FC1C-F248-11E8-B48F-1D18A9856A87
  last_name: Abbas
- first_name: García J
  full_name: Hernández, García J
  last_name: Hernández
- first_name: Stephan
  full_name: Pollmann, Stephan
  last_name: Pollmann
- first_name: Sophia L
  full_name: Samodelov, Sophia L
  last_name: Samodelov
- first_name: Martina
  full_name: Kolb, Martina
  last_name: Kolb
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Ulrich Z
  full_name: Hammes, Ulrich Z
  last_name: Hammes
- first_name: Matias D
  full_name: Zurbriggen, Matias D
  last_name: Zurbriggen
- first_name: Miguel
  full_name: Blázquez, Miguel
  last_name: Blázquez
- first_name: David
  full_name: Alabadí, David
  last_name: Alabadí
citation:
  ama: Abbas M, Hernández GJ, Pollmann S, et al. Auxin methylation is required for
    differential growth in Arabidopsis. <i>PNAS</i>. 2018;115(26):6864-6869. doi:<a
    href="https://doi.org/10.1073/pnas.1806565115">10.1073/pnas.1806565115</a>
  apa: Abbas, M., Hernández, G. J., Pollmann, S., Samodelov, S. L., Kolb, M., Friml,
    J., … Alabadí, D. (2018). Auxin methylation is required for differential growth
    in Arabidopsis. <i>PNAS</i>. National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.1806565115">https://doi.org/10.1073/pnas.1806565115</a>
  chicago: Abbas, Mohamad, García J Hernández, Stephan Pollmann, Sophia L Samodelov,
    Martina Kolb, Jiří Friml, Ulrich Z Hammes, Matias D Zurbriggen, Miguel Blázquez,
    and David Alabadí. “Auxin Methylation Is Required for Differential Growth in Arabidopsis.”
    <i>PNAS</i>. National Academy of Sciences, 2018. <a href="https://doi.org/10.1073/pnas.1806565115">https://doi.org/10.1073/pnas.1806565115</a>.
  ieee: M. Abbas <i>et al.</i>, “Auxin methylation is required for differential growth
    in Arabidopsis,” <i>PNAS</i>, vol. 115, no. 26. National Academy of Sciences,
    pp. 6864–6869, 2018.
  ista: Abbas M, Hernández GJ, Pollmann S, Samodelov SL, Kolb M, Friml J, Hammes UZ,
    Zurbriggen MD, Blázquez M, Alabadí D. 2018. Auxin methylation is required for
    differential growth in Arabidopsis. PNAS. 115(26), 6864–6869.
  mla: Abbas, Mohamad, et al. “Auxin Methylation Is Required for Differential Growth
    in Arabidopsis.” <i>PNAS</i>, vol. 115, no. 26, National Academy of Sciences,
    2018, pp. 6864–69, doi:<a href="https://doi.org/10.1073/pnas.1806565115">10.1073/pnas.1806565115</a>.
  short: M. Abbas, G.J. Hernández, S. Pollmann, S.L. Samodelov, M. Kolb, J. Friml,
    U.Z. Hammes, M.D. Zurbriggen, M. Blázquez, D. Alabadí, PNAS 115 (2018) 6864–6869.
date_created: 2018-12-11T11:45:11Z
date_published: 2018-06-26T00:00:00Z
date_updated: 2026-04-28T08:29:26Z
day: '26'
department:
- _id: JiFr
doi: 10.1073/pnas.1806565115
ec_funded: 1
external_id:
  isi:
  - '000436245000096'
fulldoi: https://doi.org/10.1073/pnas.1806565115
intvolume: '       115'
isi: 1
issue: '26'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://eprints.nottingham.ac.uk/52388/
month: '06'
oa: 1
oa_version: Submitted Version
page: 6864-6869
project:
- _id: 25716A02-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '282300'
  name: Polarity and subcellular dynamics in plants
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '7710'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Auxin methylation is required for differential growth in Arabidopsis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 115
year: '2018'
...
---
_id: '10357'
abstract:
- lang: eng
  text: The misfolding and aggregation of proteins into linear fibrils is widespread
    in human biology, for example, in connection with amyloid formation and the pathology
    of neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. The
    oligomeric species that are formed in the early stages of protein aggregation
    are of great interest, having been linked with the cellular toxicity associated
    with these conditions. However, these species are not characterized in any detail
    experimentally, and their properties are not well understood. Many of these species
    have been found to have approximately spherical morphology and to be held together
    by hydrophobic interactions. We present here an analytical statistical mechanical
    model of globular oligomer formation from simple idealized amphiphilic protein
    monomers and show that this correlates well with Monte Carlo simulations of oligomer
    formation. We identify the controlling parameters of the model, which are closely
    related to simple quantities that may be fitted directly from experiment. We predict
    that globular oligomers are unlikely to form at equilibrium in many polypeptide
    systems but instead form transiently in the early stages of amyloid formation.
    We contrast the globular model of oligomer formation to a well-established model
    of linear oligomer formation, highlighting how the differing ensemble properties
    of linear and globular oligomers offer a potential strategy for characterizing
    oligomers from experimental measurements.
acknowledgement: We acknowledge support from the Schiff Foundation (A.J.D.), the Royal
  Society (A.Š.), the Academy of Medical Sciences and Wellcome Trust (A.Š.), Peterhouse,
  Cambridge (T.C.T.M.), the Swiss National Science foundation (T.C.T.M.), the Wellcome
  Trust (T.P.J.K.), the Cambridge Centre for Misfolding Diseases (T.P.J.K.), the BBSRC
  (T.P.J.K.), the Frances and Augustus Newman foundation (T.P.J.K.). The research
  leading to these results has received funding from the European Research Council
  under the European Union’s Seventh Framework Programme (Grant FP7/2007-2013) through
  the ERC Grant PhysProt (Agreement No. 337969). We thank Daan Frenkel for several
  useful discussions.
article_processing_charge: No
article_type: original
author:
- first_name: Alexander J.
  full_name: Dear, Alexander J.
  last_name: Dear
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
- first_name: Thomas C. T.
  full_name: Michaels, Thomas C. T.
  last_name: Michaels
- first_name: Christopher M.
  full_name: Dobson, Christopher M.
  last_name: Dobson
- first_name: Tuomas P. J.
  full_name: Knowles, Tuomas P. J.
  last_name: Knowles
citation:
  ama: Dear AJ, Šarić A, Michaels TCT, Dobson CM, Knowles TPJ. Statistical mechanics
    of globular oligomer formation by protein molecules. <i>The Journal of Physical
    Chemistry B</i>. 2018;122(49):11721-11730. doi:<a href="https://doi.org/10.1021/acs.jpcb.8b07805">10.1021/acs.jpcb.8b07805</a>
  apa: Dear, A. J., Šarić, A., Michaels, T. C. T., Dobson, C. M., &#38; Knowles, T.
    P. J. (2018). Statistical mechanics of globular oligomer formation by protein
    molecules. <i>The Journal of Physical Chemistry B</i>. American Chemical Society.
    <a href="https://doi.org/10.1021/acs.jpcb.8b07805">https://doi.org/10.1021/acs.jpcb.8b07805</a>
  chicago: Dear, Alexander J., Anđela Šarić, Thomas C. T. Michaels, Christopher M.
    Dobson, and Tuomas P. J. Knowles. “Statistical Mechanics of Globular Oligomer
    Formation by Protein Molecules.” <i>The Journal of Physical Chemistry B</i>. American
    Chemical Society, 2018. <a href="https://doi.org/10.1021/acs.jpcb.8b07805">https://doi.org/10.1021/acs.jpcb.8b07805</a>.
  ieee: A. J. Dear, A. Šarić, T. C. T. Michaels, C. M. Dobson, and T. P. J. Knowles,
    “Statistical mechanics of globular oligomer formation by protein molecules,” <i>The
    Journal of Physical Chemistry B</i>, vol. 122, no. 49. American Chemical Society,
    pp. 11721–11730, 2018.
  ista: Dear AJ, Šarić A, Michaels TCT, Dobson CM, Knowles TPJ. 2018. Statistical
    mechanics of globular oligomer formation by protein molecules. The Journal of
    Physical Chemistry B. 122(49), 11721–11730.
  mla: Dear, Alexander J., et al. “Statistical Mechanics of Globular Oligomer Formation
    by Protein Molecules.” <i>The Journal of Physical Chemistry B</i>, vol. 122, no.
    49, American Chemical Society, 2018, pp. 11721–30, doi:<a href="https://doi.org/10.1021/acs.jpcb.8b07805">10.1021/acs.jpcb.8b07805</a>.
  short: A.J. Dear, A. Šarić, T.C.T. Michaels, C.M. Dobson, T.P.J. Knowles, The Journal
    of Physical Chemistry B 122 (2018) 11721–11730.
date_created: 2021-11-26T11:55:12Z
date_published: 2018-10-18T00:00:00Z
date_updated: 2021-11-26T12:40:02Z
day: '18'
doi: 10.1021/acs.jpcb.8b07805
extern: '1'
external_id:
  pmid:
  - '30336667'
fulldoi: https://doi.org/10.1021/acs.jpcb.8b07805
intvolume: '       122'
issue: '49'
keyword:
- materials chemistry
language:
- iso: eng
month: '10'
oa_version: None
page: 11721-11730
pmid: 1
publication: The Journal of Physical Chemistry B
publication_identifier:
  eissn:
  - 1520-5207
  issn:
  - 1520-6106
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Statistical mechanics of globular oligomer formation by protein molecules
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 122
year: '2018'
...
---
_id: '10358'
abstract:
- lang: eng
  text: Probing reaction mechanisms of supramolecular processes in soft and biological
    matter, such as protein aggregation, is inherently challenging. This is because
    these processes involve multiple molecular mechanisms that are associated with
    the rearrangement of large numbers of weak bonds, resulting in complex free energy
    landscapes with many kinetic barriers. Reaction rate measurements at different
    temperatures can offer unprecedented insights into the underlying molecular mechanisms.
    However, to be able to interpret such measurements, a key challenge is to establish
    which properties of the complex free energy landscapes are probed by the reaction
    rate. Here, we present a reaction rate theory for supramolecular kinetics based
    on Kramers theory of diffusive reactions over multiple kinetic barriers. We find
    that reaction rates for protein aggregation are of the Arrhenius–Eyring type and
    that the associated activation energies probe only one relevant barrier along
    the respective free energy landscapes. We apply this advancement to interpret,
    in experiments and in coarse-grained computer simulations, reaction rates of amyloid
    aggregation in terms of molecular mechanisms and associated thermodynamic signatures.
    These results suggest a practical extension of the concept of rate-determining
    steps for complex supramolecular processes and establish a general platform for
    probing the underlying energy landscape using kinetic measurements.
acknowledgement: We thank Claudia Flandoli for the help with illustrations.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Thomas C. T.
  full_name: Michaels, Thomas C. T.
  last_name: Michaels
- first_name: Lucie X.
  full_name: Liu, Lucie X.
  last_name: Liu
- first_name: Samo
  full_name: Curk, Samo
  last_name: Curk
- first_name: Peter G.
  full_name: Bolhuis, Peter G.
  last_name: Bolhuis
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
- first_name: Tuomas P. J.
  full_name: Knowles, Tuomas P. J.
  last_name: Knowles
citation:
  ama: 'Michaels TCT, Liu LX, Curk S, Bolhuis PG, Šarić A, Knowles TPJ. Reaction rate
    theory for supramolecular kinetics: application to protein aggregation. <i>Molecular
    Physics</i>. 2018;116(21-22):3055-3065. doi:<a href="https://doi.org/10.1080/00268976.2018.1474280">10.1080/00268976.2018.1474280</a>'
  apa: 'Michaels, T. C. T., Liu, L. X., Curk, S., Bolhuis, P. G., Šarić, A., &#38;
    Knowles, T. P. J. (2018). Reaction rate theory for supramolecular kinetics: application
    to protein aggregation. <i>Molecular Physics</i>. Taylor &#38; Francis. <a href="https://doi.org/10.1080/00268976.2018.1474280">https://doi.org/10.1080/00268976.2018.1474280</a>'
  chicago: 'Michaels, Thomas C. T., Lucie X. Liu, Samo Curk, Peter G. Bolhuis, Anđela
    Šarić, and Tuomas P. J. Knowles. “Reaction Rate Theory for Supramolecular Kinetics:
    Application to Protein Aggregation.” <i>Molecular Physics</i>. Taylor &#38; Francis,
    2018. <a href="https://doi.org/10.1080/00268976.2018.1474280">https://doi.org/10.1080/00268976.2018.1474280</a>.'
  ieee: 'T. C. T. Michaels, L. X. Liu, S. Curk, P. G. Bolhuis, A. Šarić, and T. P.
    J. Knowles, “Reaction rate theory for supramolecular kinetics: application to
    protein aggregation,” <i>Molecular Physics</i>, vol. 116, no. 21–22. Taylor &#38;
    Francis, pp. 3055–3065, 2018.'
  ista: 'Michaels TCT, Liu LX, Curk S, Bolhuis PG, Šarić A, Knowles TPJ. 2018. Reaction
    rate theory for supramolecular kinetics: application to protein aggregation. Molecular
    Physics. 116(21–22), 3055–3065.'
  mla: 'Michaels, Thomas C. T., et al. “Reaction Rate Theory for Supramolecular Kinetics:
    Application to Protein Aggregation.” <i>Molecular Physics</i>, vol. 116, no. 21–22,
    Taylor &#38; Francis, 2018, pp. 3055–65, doi:<a href="https://doi.org/10.1080/00268976.2018.1474280">10.1080/00268976.2018.1474280</a>.'
  short: T.C.T. Michaels, L.X. Liu, S. Curk, P.G. Bolhuis, A. Šarić, T.P.J. Knowles,
    Molecular Physics 116 (2018) 3055–3065.
date_created: 2021-11-26T12:08:02Z
date_published: 2018-05-24T00:00:00Z
date_updated: 2021-11-26T12:39:58Z
day: '24'
doi: 10.1080/00268976.2018.1474280
extern: '1'
external_id:
  arxiv:
  - '1803.04851'
fulldoi: https://doi.org/10.1080/00268976.2018.1474280
intvolume: '       116'
issue: 21-22
keyword:
- physical chemistry
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1803.04851
month: '05'
oa: 1
oa_version: Preprint
page: 3055-3065
publication: Molecular Physics
publication_identifier:
  eissn:
  - 1362-3028
  issn:
  - 0026-8976
publication_status: published
publisher: Taylor & Francis
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Reaction rate theory for supramolecular kinetics: application to protein aggregation'
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 116
year: '2018'
...
---
_id: '10359'
abstract:
- lang: eng
  text: Biological membranes typically contain a large number of different components
    dispersed in small concentrations in the main membrane phase, including proteins,
    sugars, and lipids of varying geometrical properties. Most of these components
    do not bind the cargo. Here, we show that such “inert” components can be crucial
    for the precise control of cross-membrane trafficking. Using a statistical mechanics
    model and molecular dynamics simulations, we demonstrate that the presence of
    inert membrane components of small isotropic curvatures dramatically influences
    cargo endocytosis, even if the total spontaneous curvature of such a membrane
    remains unchanged. Curved lipids, such as cholesterol, as well as asymmetrically
    included proteins and tethered sugars can, therefore, actively participate in
    the control of the membrane trafficking of nanoscopic cargo. We find that even
    a low-level expression of curved inert membrane components can determine the membrane
    selectivity toward the cargo size and can be used to selectively target membranes
    of certain compositions. Our results suggest a robust and general method of controlling
    cargo trafficking by adjusting the membrane composition without needing to alter
    the concentration of receptors or the average membrane curvature. This study indicates
    that cells can prepare for any trafficking event by incorporating curved inert
    components in either of the membrane leaflets.
acknowledgement: We acknowledge discussions with Giuseppe Battaglia as well as support
  from the Herchel Smith scholarship (T.C.), the CAS PIFI fellowship (T.C.), the UCL
  Institute for the Physics of Living Systems (T.C. and A.Š.), the Austrian Academy
  of Sciences through a DOC fellowship (P.W.), the European Union Horizon 2020 programme
  under ETN grant no. 674979-NANOTRANS and FET grant no. 766972-NANOPHLOW (J.D. and
  D.F.), the Engineering and Physical Sciences Research Council (D.F. and A.Š.), the
  Academy of Medical Sciences and Wellcome Trust (A.Š.), and the Royal Society (A.Š.).
  We thank Claudia Flandoli for help with Figure 1.
article_processing_charge: No
article_type: original
author:
- first_name: Tine
  full_name: Curk, Tine
  last_name: Curk
- first_name: Peter
  full_name: Wirnsberger, Peter
  last_name: Wirnsberger
- first_name: Jure
  full_name: Dobnikar, Jure
  last_name: Dobnikar
- first_name: Daan
  full_name: Frenkel, Daan
  last_name: Frenkel
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
citation:
  ama: Curk T, Wirnsberger P, Dobnikar J, Frenkel D, Šarić A. Controlling cargo trafficking
    in multicomponent membranes. <i>Nano Letters</i>. 2018;18(9):5350-5356. doi:<a
    href="https://doi.org/10.1021/acs.nanolett.8b00786">10.1021/acs.nanolett.8b00786</a>
  apa: Curk, T., Wirnsberger, P., Dobnikar, J., Frenkel, D., &#38; Šarić, A. (2018).
    Controlling cargo trafficking in multicomponent membranes. <i>Nano Letters</i>.
    American Chemical Society. <a href="https://doi.org/10.1021/acs.nanolett.8b00786">https://doi.org/10.1021/acs.nanolett.8b00786</a>
  chicago: Curk, Tine, Peter Wirnsberger, Jure Dobnikar, Daan Frenkel, and Anđela
    Šarić. “Controlling Cargo Trafficking in Multicomponent Membranes.” <i>Nano Letters</i>.
    American Chemical Society, 2018. <a href="https://doi.org/10.1021/acs.nanolett.8b00786">https://doi.org/10.1021/acs.nanolett.8b00786</a>.
  ieee: T. Curk, P. Wirnsberger, J. Dobnikar, D. Frenkel, and A. Šarić, “Controlling
    cargo trafficking in multicomponent membranes,” <i>Nano Letters</i>, vol. 18,
    no. 9. American Chemical Society, pp. 5350–5356, 2018.
  ista: Curk T, Wirnsberger P, Dobnikar J, Frenkel D, Šarić A. 2018. Controlling cargo
    trafficking in multicomponent membranes. Nano Letters. 18(9), 5350–5356.
  mla: Curk, Tine, et al. “Controlling Cargo Trafficking in Multicomponent Membranes.”
    <i>Nano Letters</i>, vol. 18, no. 9, American Chemical Society, 2018, pp. 5350–56,
    doi:<a href="https://doi.org/10.1021/acs.nanolett.8b00786">10.1021/acs.nanolett.8b00786</a>.
  short: T. Curk, P. Wirnsberger, J. Dobnikar, D. Frenkel, A. Šarić, Nano Letters
    18 (2018) 5350–5356.
date_created: 2021-11-26T12:15:47Z
date_published: 2018-04-18T00:00:00Z
date_updated: 2021-11-26T15:14:08Z
day: '18'
doi: 10.1021/acs.nanolett.8b00786
extern: '1'
external_id:
  pmid:
  - '29667410'
fulldoi: https://doi.org/10.1021/acs.nanolett.8b00786
intvolume: '        18'
issue: '9'
keyword:
- mechanical engineering
- condensed matter physics
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1712.10147
month: '04'
oa: 1
oa_version: Preprint
page: 5350-5356
pmid: 1
publication: Nano Letters
publication_identifier:
  eissn:
  - 1530-6992
  issn:
  - 1530-6984
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Controlling cargo trafficking in multicomponent membranes
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 18
year: '2018'
...
---
_id: '10360'
abstract:
- lang: eng
  text: Mapping free-energy landscapes has proved to be a powerful tool for studying
    reaction mechanisms. Many complex biomolecular assembly processes, however, have
    remained challenging to access using this approach, including the aggregation
    of peptides and proteins into amyloid fibrils implicated in a range of disorders.
    Here, we generalize the strategy used to probe free-energy landscapes in protein
    folding to determine the activation energies and entropies that characterize each
    of the molecular steps in the aggregation of the amyloid-β peptide (Aβ42), which
    is associated with Alzheimer’s disease. Our results reveal that interactions between
    monomeric Aβ42 and amyloid fibrils during fibril-dependent secondary nucleation
    fundamentally reverse the thermodynamic signature of this process relative to
    primary nucleation, even though both processes generate aggregates from soluble
    peptides. By mapping the energetic and entropic contributions along the reaction
    trajectories, we show that the catalytic efficiency of Aβ42 fibril surfaces results
    from the enthalpic stabilization of adsorbing peptides in conformations amenable
    to nucleation, resulting in a dramatic lowering of the activation energy for nucleation.
acknowledgement: We thank B. Jönsson and I. André for helpful discussions. We acknowledge
  financial support from the Schiff Foundation (S.I.A.C.), St John’s College, Cambridge
  (S.I.A.C.), the Royal Physiographic Society (R.C.), the Research School FLÄK of
  Lund University (S.L., R.C.), the Swedish Research Council (S.L.) and its Linneaus
  Centre Organizing Molecular Matter (S.L.), the Crafoord Foundation (S.L.), Alzheimerfonden
  (S.L.), the European Research Council (S.L.), NanoLund (S.L.), Knut and Alice Wallenberg
  Foundation (S.L.), Peterhouse, Cambridge (T.C.T.M.), the Swiss National Science
  Foundation (T.C.T.M.), Magdalene College, Cambridge (A.K.B.), the Leverhulme Trust
  (A.K.B.), the Royal Society (A.Š.), the Academy of Medical Sciences (A.Š.), the
  Wellcome Trust (C.M.D., T.P.J.K., A.Š.), and the Centre for Misfolding Diseases
  (C.M.D., T.P.J.K, M.V.). A.K.B. thanks the Alzheimer Forschung Initiative (AFI).
article_processing_charge: No
article_type: original
author:
- first_name: Samuel I. A.
  full_name: Cohen, Samuel I. A.
  last_name: Cohen
- first_name: Risto
  full_name: Cukalevski, Risto
  last_name: Cukalevski
- first_name: Thomas C. T.
  full_name: Michaels, Thomas C. T.
  last_name: Michaels
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
- first_name: Mattias
  full_name: Törnquist, Mattias
  last_name: Törnquist
- first_name: Michele
  full_name: Vendruscolo, Michele
  last_name: Vendruscolo
- first_name: Christopher M.
  full_name: Dobson, Christopher M.
  last_name: Dobson
- first_name: Alexander K.
  full_name: Buell, Alexander K.
  last_name: Buell
- first_name: Tuomas P. J.
  full_name: Knowles, Tuomas P. J.
  last_name: Knowles
- first_name: Sara
  full_name: Linse, Sara
  last_name: Linse
citation:
  ama: Cohen SIA, Cukalevski R, Michaels TCT, et al. Distinct thermodynamic signatures
    of oligomer generation in the aggregation of the amyloid-β peptide. <i>Nature
    Chemistry</i>. 2018;10(5):523-531. doi:<a href="https://doi.org/10.1038/s41557-018-0023-x">10.1038/s41557-018-0023-x</a>
  apa: Cohen, S. I. A., Cukalevski, R., Michaels, T. C. T., Šarić, A., Törnquist,
    M., Vendruscolo, M., … Linse, S. (2018). Distinct thermodynamic signatures of
    oligomer generation in the aggregation of the amyloid-β peptide. <i>Nature Chemistry</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41557-018-0023-x">https://doi.org/10.1038/s41557-018-0023-x</a>
  chicago: Cohen, Samuel I. A., Risto Cukalevski, Thomas C. T. Michaels, Anđela Šarić,
    Mattias Törnquist, Michele Vendruscolo, Christopher M. Dobson, Alexander K. Buell,
    Tuomas P. J. Knowles, and Sara Linse. “Distinct Thermodynamic Signatures of Oligomer
    Generation in the Aggregation of the Amyloid-β Peptide.” <i>Nature Chemistry</i>.
    Springer Nature, 2018. <a href="https://doi.org/10.1038/s41557-018-0023-x">https://doi.org/10.1038/s41557-018-0023-x</a>.
  ieee: S. I. A. Cohen <i>et al.</i>, “Distinct thermodynamic signatures of oligomer
    generation in the aggregation of the amyloid-β peptide,” <i>Nature Chemistry</i>,
    vol. 10, no. 5. Springer Nature, pp. 523–531, 2018.
  ista: Cohen SIA, Cukalevski R, Michaels TCT, Šarić A, Törnquist M, Vendruscolo M,
    Dobson CM, Buell AK, Knowles TPJ, Linse S. 2018. Distinct thermodynamic signatures
    of oligomer generation in the aggregation of the amyloid-β peptide. Nature Chemistry.
    10(5), 523–531.
  mla: Cohen, Samuel I. A., et al. “Distinct Thermodynamic Signatures of Oligomer
    Generation in the Aggregation of the Amyloid-β Peptide.” <i>Nature Chemistry</i>,
    vol. 10, no. 5, Springer Nature, 2018, pp. 523–31, doi:<a href="https://doi.org/10.1038/s41557-018-0023-x">10.1038/s41557-018-0023-x</a>.
  short: S.I.A. Cohen, R. Cukalevski, T.C.T. Michaels, A. Šarić, M. Törnquist, M.
    Vendruscolo, C.M. Dobson, A.K. Buell, T.P.J. Knowles, S. Linse, Nature Chemistry
    10 (2018) 523–531.
date_created: 2021-11-26T12:41:38Z
date_published: 2018-03-26T00:00:00Z
date_updated: 2021-11-26T15:14:00Z
day: '26'
doi: 10.1038/s41557-018-0023-x
extern: '1'
external_id:
  pmid:
  - '29581486'
fulldoi: https://doi.org/10.1038/s41557-018-0023-x
intvolume: '        10'
issue: '5'
keyword:
- general chemical engineering
- general chemistry
language:
- iso: eng
month: '03'
oa_version: None
page: 523-531
pmid: 1
publication: Nature Chemistry
publication_identifier:
  eissn:
  - 1755-4349
  issn:
  - 1755-4330
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distinct thermodynamic signatures of oligomer generation in the aggregation
  of the amyloid-β peptide
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 10
year: '2018'
...
