---
_id: '3300'
abstract:
- lang: eng
  text: "This book first explores the origins of this idea, grounded in theoretical
    work on temporal logic and automata. The editors and authors are among the world's
    leading researchers in this domain, and they contributed 32 chapters representing
    a thorough view of the development and application of the technique. Topics covered
    include binary decision diagrams, symbolic model checking, satisfiability modulo
    theories, partial-order reduction, abstraction, interpolation, concurrency, security
    protocols, games, probabilistic model checking, and process algebra, and chapters
    on the transfer of theory to industrial practice, property specification languages
    for hardware, and verification of real-time systems and hybrid systems.\r\n\r\nThe
    book will be valuable for researchers and graduate students engaged with the development
    of formal methods and verification tools."
article_processing_charge: No
author:
- first_name: Edmund M.
  full_name: Clarke, Edmund M.
  last_name: Clarke
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Helmut
  full_name: Veith, Helmut
  last_name: Veith
- first_name: Roderick
  full_name: Bloem, Roderick
  last_name: Bloem
citation:
  ama: 'Clarke EM, Henzinger TA, Veith H, Bloem R. <i>Handbook of Model Checking</i>.
    1st ed. Cham: Springer Nature; 2018. doi:<a href="https://doi.org/10.1007/978-3-319-10575-8">10.1007/978-3-319-10575-8</a>'
  apa: 'Clarke, E. M., Henzinger, T. A., Veith, H., &#38; Bloem, R. (2018). <i>Handbook
    of Model Checking</i> (1st ed.). Cham: Springer Nature. <a href="https://doi.org/10.1007/978-3-319-10575-8">https://doi.org/10.1007/978-3-319-10575-8</a>'
  chicago: 'Clarke, Edmund M., Thomas A Henzinger, Helmut Veith, and Roderick Bloem.
    <i>Handbook of Model Checking</i>. 1st ed. Cham: Springer Nature, 2018. <a href="https://doi.org/10.1007/978-3-319-10575-8">https://doi.org/10.1007/978-3-319-10575-8</a>.'
  ieee: 'E. M. Clarke, T. A. Henzinger, H. Veith, and R. Bloem, <i>Handbook of Model
    Checking</i>, 1st ed. Cham: Springer Nature, 2018.'
  ista: 'Clarke EM, Henzinger TA, Veith H, Bloem R. 2018. Handbook of Model Checking
    1st ed., Cham: Springer Nature, XLVIII, 1212p.'
  mla: Clarke, Edmund M., et al. <i>Handbook of Model Checking</i>. 1st ed., Springer
    Nature, 2018, doi:<a href="https://doi.org/10.1007/978-3-319-10575-8">10.1007/978-3-319-10575-8</a>.
  short: E.M. Clarke, T.A. Henzinger, H. Veith, R. Bloem, Handbook of Model Checking,
    1st ed., Springer Nature, Cham, 2018.
date_created: 2018-12-11T12:02:32Z
date_published: 2018-06-08T00:00:00Z
date_updated: 2021-12-21T10:49:36Z
day: '08'
department:
- _id: ToHe
doi: 10.1007/978-3-319-10575-8
edition: '1'
fulldoi: https://doi.org/10.1007/978-3-319-10575-8
language:
- iso: eng
month: '06'
oa_version: None
page: XLVIII, 1212
place: Cham
publication_identifier:
  eisbn:
  - 978-3-319-10575-8
  isbn:
  - 978-3-319-10574-1
publication_status: published
publisher: Springer Nature
publist_id: '3340'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Handbook of Model Checking
type: book
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2018'
...
---
_id: '36'
abstract:
- lang: eng
  text: Wheat (Triticum ssp.) is one of the most important human food sources. However,
    this crop is very sensitive to temperature changes. Specifically, processes during
    wheat leaf, flower, and seed development and photosynthesis, which all contribute
    to the yield of this crop, are affected by high temperature. While this has to
    some extent been investigated on physiological, developmental, and molecular levels,
    very little is known about early signalling events associated with an increase
    in temperature. Phosphorylation-mediated signalling mechanisms, which are quick
    and dynamic, are associated with plant growth and development, also under abiotic
    stress conditions. Therefore, we probed the impact of a short-term and mild increase
    in temperature on the wheat leaf and spikelet phosphoproteome. In total, 3822
    (containing 5178 phosphosites) and 5581 phosphopeptides (containing 7023 phosphosites)
    were identified in leaf and spikelet samples, respectively. Following statistical
    analysis, the resulting data set provides the scientific community with a first
    large-scale plant phosphoproteome under the control of higher ambient temperature.
    This community resource on the high temperature-mediated wheat phosphoproteome
    will be valuable for future studies. Our analyses also revealed a core set of
    common proteins between leaf and spikelet, suggesting some level of conserved
    regulatory mechanisms. Furthermore, we observed temperature-regulated interconversion
    of phosphoforms, which probably impacts protein activity.
acknowledgement: TZ is supported by a grant from the Chinese Scholarship Council.
article_processing_charge: No
author:
- first_name: Lam
  full_name: Vu, Lam
  last_name: Vu
- first_name: Tingting
  full_name: Zhu, Tingting
  last_name: Zhu
- first_name: Inge
  full_name: Verstraeten, Inge
  id: 362BF7FE-F248-11E8-B48F-1D18A9856A87
  last_name: Verstraeten
  orcid: 0000-0001-7241-2328
- first_name: Brigitte
  full_name: Van De Cotte, Brigitte
  last_name: Van De Cotte
- first_name: Kris
  full_name: Gevaert, Kris
  last_name: Gevaert
- first_name: Ive
  full_name: De Smet, Ive
  last_name: De Smet
citation:
  ama: Vu L, Zhu T, Verstraeten I, Van De Cotte B, Gevaert K, De Smet I. Temperature-induced
    changes in the wheat phosphoproteome reveal temperature-regulated interconversion
    of phosphoforms. <i>Journal of Experimental Botany</i>. 2018;69(19):4609-4624.
    doi:<a href="https://doi.org/10.1093/jxb/ery204">10.1093/jxb/ery204</a>
  apa: Vu, L., Zhu, T., Verstraeten, I., Van De Cotte, B., Gevaert, K., &#38; De Smet,
    I. (2018). Temperature-induced changes in the wheat phosphoproteome reveal temperature-regulated
    interconversion of phosphoforms. <i>Journal of Experimental Botany</i>. Oxford
    University Press. <a href="https://doi.org/10.1093/jxb/ery204">https://doi.org/10.1093/jxb/ery204</a>
  chicago: Vu, Lam, Tingting Zhu, Inge Verstraeten, Brigitte Van De Cotte, Kris Gevaert,
    and Ive De Smet. “Temperature-Induced Changes in the Wheat Phosphoproteome Reveal
    Temperature-Regulated Interconversion of Phosphoforms.” <i>Journal of Experimental
    Botany</i>. Oxford University Press, 2018. <a href="https://doi.org/10.1093/jxb/ery204">https://doi.org/10.1093/jxb/ery204</a>.
  ieee: L. Vu, T. Zhu, I. Verstraeten, B. Van De Cotte, K. Gevaert, and I. De Smet,
    “Temperature-induced changes in the wheat phosphoproteome reveal temperature-regulated
    interconversion of phosphoforms,” <i>Journal of Experimental Botany</i>, vol.
    69, no. 19. Oxford University Press, pp. 4609–4624, 2018.
  ista: Vu L, Zhu T, Verstraeten I, Van De Cotte B, Gevaert K, De Smet I. 2018. Temperature-induced
    changes in the wheat phosphoproteome reveal temperature-regulated interconversion
    of phosphoforms. Journal of Experimental Botany. 69(19), 4609–4624.
  mla: Vu, Lam, et al. “Temperature-Induced Changes in the Wheat Phosphoproteome Reveal
    Temperature-Regulated Interconversion of Phosphoforms.” <i>Journal of Experimental
    Botany</i>, vol. 69, no. 19, Oxford University Press, 2018, pp. 4609–24, doi:<a
    href="https://doi.org/10.1093/jxb/ery204">10.1093/jxb/ery204</a>.
  short: L. Vu, T. Zhu, I. Verstraeten, B. Van De Cotte, K. Gevaert, I. De Smet, Journal
    of Experimental Botany 69 (2018) 4609–4624.
date_created: 2018-12-11T11:44:17Z
date_published: 2018-08-31T00:00:00Z
date_updated: 2023-09-19T10:00:46Z
day: '31'
ddc:
- '581'
department:
- _id: JiFr
doi: 10.1093/jxb/ery204
external_id:
  isi:
  - '000443568700010'
file:
- access_level: open_access
  checksum: 34cb0a1611588b75bd6f4913fb4e30f1
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-18T09:47:51Z
  date_updated: 2020-07-14T12:46:13Z
  file_id: '5741'
  file_name: 2018_JournalExperimBotany_Vu.pdf
  file_size: 3359316
  relation: main_file
file_date_updated: 2020-07-14T12:46:13Z
fulldoi: https://doi.org/10.1093/jxb/ery204
has_accepted_license: '1'
intvolume: '        69'
isi: 1
issue: '19'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '08'
oa: 1
oa_version: Published Version
page: 4609 - 4624
publication: Journal of Experimental Botany
publication_status: published
publisher: Oxford University Press
publist_id: '8019'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Temperature-induced changes in the wheat phosphoproteome reveal temperature-regulated
  interconversion of phosphoforms
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 69
year: '2018'
...
---
_id: '37'
abstract:
- lang: eng
  text: Developmental processes are inherently dynamic and understanding them requires
    quantitative measurements of gene and protein expression levels in space and time.
    While live imaging is a powerful approach for obtaining such data, it is still
    a challenge to apply it over long periods of time to large tissues, such as the
    embryonic spinal cord in mouse and chick. Nevertheless, dynamics of gene expression
    and signaling activity patterns in this organ can be studied by collecting tissue
    sections at different developmental stages. In combination with immunohistochemistry,
    this allows for measuring the levels of multiple developmental regulators in a
    quantitative manner with high spatiotemporal resolution. The mean protein expression
    levels over time, as well as embryo-to-embryo variability can be analyzed. A key
    aspect of the approach is the ability to compare protein levels across different
    samples. This requires a number of considerations in sample preparation, imaging
    and data analysis. Here we present a protocol for obtaining time course data of
    dorsoventral expression patterns from mouse and chick neural tube in the first
    3 days of neural tube development. The described workflow starts from embryo dissection
    and ends with a processed dataset. Software scripts for data analysis are included.
    The protocol is adaptable and instructions that allow the user to modify different
    steps are provided. Thus, the procedure can be altered for analysis of time-lapse
    images and applied to systems other than the neural tube.
alternative_title:
- Methods in Molecular Biology
article_processing_charge: No
author:
- first_name: Marcin P
  full_name: Zagórski, Marcin P
  id: 343DA0DC-F248-11E8-B48F-1D18A9856A87
  last_name: Zagórski
  orcid: 0000-0001-7896-7762
- first_name: Anna
  full_name: Kicheva, Anna
  id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
  last_name: Kicheva
  orcid: 0000-0003-4509-4998
citation:
  ama: 'Zagórski MP, Kicheva A. Measuring dorsoventral pattern and morphogen signaling
    profiles in the growing neural tube. In: <i>Morphogen Gradients </i>. Vol 1863.
    MIMB. Springer Nature; 2018:47-63. doi:<a href="https://doi.org/10.1007/978-1-4939-8772-6_4">10.1007/978-1-4939-8772-6_4</a>'
  apa: Zagórski, M. P., &#38; Kicheva, A. (2018). Measuring dorsoventral pattern and
    morphogen signaling profiles in the growing neural tube. In <i>Morphogen Gradients
    </i> (Vol. 1863, pp. 47–63). Springer Nature. <a href="https://doi.org/10.1007/978-1-4939-8772-6_4">https://doi.org/10.1007/978-1-4939-8772-6_4</a>
  chicago: Zagórski, Marcin P, and Anna Kicheva. “Measuring Dorsoventral Pattern and
    Morphogen Signaling Profiles in the Growing Neural Tube.” In <i>Morphogen Gradients
    </i>, 1863:47–63. MIMB. Springer Nature, 2018. <a href="https://doi.org/10.1007/978-1-4939-8772-6_4">https://doi.org/10.1007/978-1-4939-8772-6_4</a>.
  ieee: M. P. Zagórski and A. Kicheva, “Measuring dorsoventral pattern and morphogen
    signaling profiles in the growing neural tube,” in <i>Morphogen Gradients </i>,
    vol. 1863, Springer Nature, 2018, pp. 47–63.
  ista: 'Zagórski MP, Kicheva A. 2018.Measuring dorsoventral pattern and morphogen
    signaling profiles in the growing neural tube. In: Morphogen Gradients . Methods
    in Molecular Biology, vol. 1863, 47–63.'
  mla: Zagórski, Marcin P., and Anna Kicheva. “Measuring Dorsoventral Pattern and
    Morphogen Signaling Profiles in the Growing Neural Tube.” <i>Morphogen Gradients
    </i>, vol. 1863, Springer Nature, 2018, pp. 47–63, doi:<a href="https://doi.org/10.1007/978-1-4939-8772-6_4">10.1007/978-1-4939-8772-6_4</a>.
  short: M.P. Zagórski, A. Kicheva, in:, Morphogen Gradients , Springer Nature, 2018,
    pp. 47–63.
date_created: 2018-12-11T11:44:17Z
date_published: 2018-10-16T00:00:00Z
date_updated: 2025-04-14T07:27:29Z
day: '16'
ddc:
- '570'
department:
- _id: AnKi
doi: 10.1007/978-1-4939-8772-6_4
ec_funded: 1
file:
- access_level: open_access
  checksum: 2a97d0649fdcfcf1bdca7c8ad1dce71b
  content_type: application/pdf
  creator: dernst
  date_created: 2020-10-13T14:20:37Z
  date_updated: 2020-10-13T14:20:37Z
  file_id: '8656'
  file_name: 2018_MIMB_Zagorski.pdf
  file_size: 4906815
  relation: main_file
  success: 1
file_date_updated: 2020-10-13T14:20:37Z
fulldoi: https://doi.org/10.1007/978-1-4939-8772-6_4
has_accepted_license: '1'
intvolume: '      1863'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Submitted Version
page: 47 - 63
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
  call_identifier: H2020
  grant_number: '680037'
  name: Coordination of Patterning And Growth In the Spinal Cord
publication: 'Morphogen Gradients '
publication_identifier:
  isbn:
  - 978-1-4939-8771-9
  issn:
  - 1064-3745
publication_status: published
publisher: Springer Nature
publist_id: '8018'
quality_controlled: '1'
scopus_import: '1'
series_title: MIMB
status: public
title: Measuring dorsoventral pattern and morphogen signaling profiles in the growing
  neural tube
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1863
year: '2018'
...
---
_id: '38'
abstract:
- lang: eng
  text: 'Genomes of closely-related species or populations often display localized
    regions of enhanced relative sequence divergence, termed genomic islands. It has
    been proposed that these islands arise through selective sweeps and/or barriers
    to gene flow. Here, we genetically dissect a genomic island that controls flower
    color pattern differences between two subspecies of Antirrhinum majus, A.m.striatum
    and A.m.pseudomajus, and relate it to clinal variation across a natural hybrid
    zone. We show that selective sweeps likely raised relative divergence at two tightly-linked
    MYB-like transcription factors, leading to distinct flower patterns in the two
    subspecies. The two patterns provide alternate floral guides and create a strong
    barrier to gene flow where populations come into contact. This barrier affects
    the selected flower color genes and tightlylinked loci, but does not extend outside
    of this domain, allowing gene flow to lower relative divergence for the rest of
    the chromosome. Thus, both selective sweeps and barriers to gene flow play a role
    in shaping genomic islands: sweeps cause elevation in relative divergence, while
    heterogeneous gene flow flattens the surrounding "sea," making the island of divergence
    stand out. By showing how selective sweeps establish alternative adaptive phenotypes
    that lead to barriers to gene flow, our study sheds light on possible mechanisms
    leading to reproductive isolation and speciation.'
acknowledgement: ' ERC Grant 201252 (to N.H.B.)'
article_processing_charge: No
author:
- first_name: Hugo
  full_name: Tavares, Hugo
  last_name: Tavares
- first_name: Annabel
  full_name: Whitley, Annabel
  last_name: Whitley
- first_name: David
  full_name: Field, David
  id: 419049E2-F248-11E8-B48F-1D18A9856A87
  last_name: Field
  orcid: 0000-0002-4014-8478
- first_name: Desmond
  full_name: Bradley, Desmond
  last_name: Bradley
- first_name: Matthew
  full_name: Couchman, Matthew
  last_name: Couchman
- first_name: Lucy
  full_name: Copsey, Lucy
  last_name: Copsey
- first_name: Joane
  full_name: Elleouet, Joane
  last_name: Elleouet
- first_name: Monique
  full_name: Burrus, Monique
  last_name: Burrus
- first_name: Christophe
  full_name: Andalo, Christophe
  last_name: Andalo
- first_name: Miaomiao
  full_name: Li, Miaomiao
  last_name: Li
- first_name: Qun
  full_name: Li, Qun
  last_name: Li
- first_name: Yongbiao
  full_name: Xue, Yongbiao
  last_name: Xue
- first_name: Alexandra B
  full_name: Rebocho, Alexandra B
  last_name: Rebocho
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Enrico
  full_name: Coen, Enrico
  last_name: Coen
citation:
  ama: Tavares H, Whitley A, Field D, et al. Selection and gene flow shape genomic
    islands that control floral guides. <i>PNAS</i>. 2018;115(43):11006-11011. doi:<a
    href="https://doi.org/10.1073/pnas.1801832115">10.1073/pnas.1801832115</a>
  apa: Tavares, H., Whitley, A., Field, D., Bradley, D., Couchman, M., Copsey, L.,
    … Coen, E. (2018). Selection and gene flow shape genomic islands that control
    floral guides. <i>PNAS</i>. National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.1801832115">https://doi.org/10.1073/pnas.1801832115</a>
  chicago: Tavares, Hugo, Annabel Whitley, David Field, Desmond Bradley, Matthew Couchman,
    Lucy Copsey, Joane Elleouet, et al. “Selection and Gene Flow Shape Genomic Islands
    That Control Floral Guides.” <i>PNAS</i>. National Academy of Sciences, 2018.
    <a href="https://doi.org/10.1073/pnas.1801832115">https://doi.org/10.1073/pnas.1801832115</a>.
  ieee: H. Tavares <i>et al.</i>, “Selection and gene flow shape genomic islands that
    control floral guides,” <i>PNAS</i>, vol. 115, no. 43. National Academy of Sciences,
    pp. 11006–11011, 2018.
  ista: Tavares H, Whitley A, Field D, Bradley D, Couchman M, Copsey L, Elleouet J,
    Burrus M, Andalo C, Li M, Li Q, Xue Y, Rebocho AB, Barton NH, Coen E. 2018. Selection
    and gene flow shape genomic islands that control floral guides. PNAS. 115(43),
    11006–11011.
  mla: Tavares, Hugo, et al. “Selection and Gene Flow Shape Genomic Islands That Control
    Floral Guides.” <i>PNAS</i>, vol. 115, no. 43, National Academy of Sciences, 2018,
    pp. 11006–11, doi:<a href="https://doi.org/10.1073/pnas.1801832115">10.1073/pnas.1801832115</a>.
  short: H. Tavares, A. Whitley, D. Field, D. Bradley, M. Couchman, L. Copsey, J.
    Elleouet, M. Burrus, C. Andalo, M. Li, Q. Li, Y. Xue, A.B. Rebocho, N.H. Barton,
    E. Coen, PNAS 115 (2018) 11006–11011.
date_created: 2018-12-11T11:44:18Z
date_published: 2018-10-23T00:00:00Z
date_updated: 2025-07-10T11:52:32Z
day: '23'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1073/pnas.1801832115
external_id:
  isi:
  - '000448040500065'
  pmid:
  - '30297406'
file:
- access_level: open_access
  checksum: d2305d0cc81dbbe4c1c677d64ad6f6d1
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T08:44:03Z
  date_updated: 2020-07-14T12:46:16Z
  file_id: '5683'
  file_name: 11006.full.pdf
  file_size: 1911302
  relation: main_file
file_date_updated: 2020-07-14T12:46:16Z
fulldoi: https://doi.org/10.1073/pnas.1801832115
has_accepted_license: '1'
intvolume: '       115'
isi: 1
issue: '43'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '10'
oa: 1
oa_version: Published Version
page: 11006 - 11011
pmid: 1
publication: PNAS
publication_identifier:
  issn:
  - 0027-8424
publication_status: published
publisher: National Academy of Sciences
publist_id: '8017'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Selection and gene flow shape genomic islands that control floral guides
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 115
year: '2018'
...
---
_id: '384'
abstract:
- lang: eng
  text: Can orthologous proteins differ in terms of their ability to be secreted?
    To answer this question, we investigated the distribution of signal peptides within
    the orthologous groups of Enterobacterales. Parsimony analysis and sequence comparisons
    revealed a large number of signal peptide gain and loss events, in which signal
    peptides emerge or disappear in the course of evolution. Signal peptide losses
    prevail over gains, an effect which is especially pronounced in the transition
    from the free-living or commensal to the endosymbiotic lifestyle. The disproportionate
    decline in the number of signal peptide-containing proteins in endosymbionts cannot
    be explained by the overall reduction of their genomes. Signal peptides can be
    gained and lost either by acquisition/elimination of the corresponding N-terminal
    regions or by gradual accumulation of mutations. The evolutionary dynamics of
    signal peptides in bacterial proteins represents a powerful mechanism of functional
    diversification.
acknowledgement: "his work was supported by the Deutsche Forschungsgemeinschaft  (grant
  \ number  FR  1411/9-1).  This work  was  supported  by  the  German  Research  Foundation
  (DFG) and the Technical University of Munich within the fund- ing programme Open
  Access Publish\r\nWe thank Goar Frishman for help with the annotation of the\r\nsymbiont
  status of the organisms and Michael Galperin for\r\nuseful comments. T"
article_processing_charge: No
author:
- first_name: Peter
  full_name: Hönigschmid, Peter
  last_name: Hönigschmid
- first_name: Nadya
  full_name: Bykova, Nadya
  last_name: Bykova
- first_name: René
  full_name: Schneider, René
  last_name: Schneider
- first_name: Dmitry
  full_name: Ivankov, Dmitry
  id: 49FF1036-F248-11E8-B48F-1D18A9856A87
  last_name: Ivankov
- first_name: Dmitrij
  full_name: Frishman, Dmitrij
  last_name: Frishman
citation:
  ama: Hönigschmid P, Bykova N, Schneider R, Ivankov D, Frishman D. Evolutionary interplay
    between symbiotic relationships and patterns of signal peptide gain and loss.
    <i>Genome Biology and Evolution</i>. 2018;10(3):928-938. doi:<a href="https://doi.org/10.1093/gbe/evy049">10.1093/gbe/evy049</a>
  apa: Hönigschmid, P., Bykova, N., Schneider, R., Ivankov, D., &#38; Frishman, D.
    (2018). Evolutionary interplay between symbiotic relationships and patterns of
    signal peptide gain and loss. <i>Genome Biology and Evolution</i>. Oxford University
    Press. <a href="https://doi.org/10.1093/gbe/evy049">https://doi.org/10.1093/gbe/evy049</a>
  chicago: Hönigschmid, Peter, Nadya Bykova, René Schneider, Dmitry Ivankov, and Dmitrij
    Frishman. “Evolutionary Interplay between Symbiotic Relationships and Patterns
    of Signal Peptide Gain and Loss.” <i>Genome Biology and Evolution</i>. Oxford
    University Press, 2018. <a href="https://doi.org/10.1093/gbe/evy049">https://doi.org/10.1093/gbe/evy049</a>.
  ieee: P. Hönigschmid, N. Bykova, R. Schneider, D. Ivankov, and D. Frishman, “Evolutionary
    interplay between symbiotic relationships and patterns of signal peptide gain
    and loss,” <i>Genome Biology and Evolution</i>, vol. 10, no. 3. Oxford University
    Press, pp. 928–938, 2018.
  ista: Hönigschmid P, Bykova N, Schneider R, Ivankov D, Frishman D. 2018. Evolutionary
    interplay between symbiotic relationships and patterns of signal peptide gain
    and loss. Genome Biology and Evolution. 10(3), 928–938.
  mla: Hönigschmid, Peter, et al. “Evolutionary Interplay between Symbiotic Relationships
    and Patterns of Signal Peptide Gain and Loss.” <i>Genome Biology and Evolution</i>,
    vol. 10, no. 3, Oxford University Press, 2018, pp. 928–38, doi:<a href="https://doi.org/10.1093/gbe/evy049">10.1093/gbe/evy049</a>.
  short: P. Hönigschmid, N. Bykova, R. Schneider, D. Ivankov, D. Frishman, Genome
    Biology and Evolution 10 (2018) 928–938.
date_created: 2018-12-11T11:46:10Z
date_published: 2018-03-01T00:00:00Z
date_updated: 2023-09-11T13:56:52Z
day: '01'
ddc:
- '576'
department:
- _id: FyKo
doi: 10.1093/gbe/evy049
external_id:
  isi:
  - '000429483700022'
file:
- access_level: open_access
  checksum: 458a7c2c2e79528567edfeb0f326cbe0
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:08:07Z
  date_updated: 2020-07-14T12:46:16Z
  file_id: '4667'
  file_name: IST-2018-999-v1+1_2018_Ivankov_Evolutionary_interplay.pdf
  file_size: 691602
  relation: main_file
file_date_updated: 2020-07-14T12:46:16Z
fulldoi: https://doi.org/10.1093/gbe/evy049
has_accepted_license: '1'
intvolume: '        10'
isi: 1
issue: '3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 928 - 938
publication: Genome Biology and Evolution
publication_status: published
publisher: Oxford University Press
publist_id: '7445'
pubrep_id: '999'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Evolutionary interplay between symbiotic relationships and patterns of signal
  peptide gain and loss
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 10
year: '2018'
...
---
_id: '39'
abstract:
- lang: eng
  text: We study how a block of genome with a large number of weakly selected loci
    introgresses under directional selection into a genetically homogeneous population.
    We derive exact expressions for the expected rate of growth of any fragment of
    the introduced block during the initial phase of introgression, and show that
    the growth rate of a single-locus variant is largely insensitive to its own additive
    effect, but depends instead on the combined effect of all loci within a characteristic
    linkage scale. The expected growth rate of a fragment is highly correlated with
    its long-term introgression probability in populations of moderate size, and can
    hence identify variants that are likely to introgress across replicate populations.
    We clarify how the introgression probability of an individual variant is determined
    by the interplay between hitchhiking with relatively large fragments during the
    early phase of introgression and selection on fine-scale variation within these,
    which at longer times results in differential introgression probabilities for
    beneficial and deleterious loci within successful fragments. By simulating individuals,
    we also investigate how introgression probabilities at individual loci depend
    on the variance of fitness effects, the net fitness of the introduced block, and
    the size of the recipient population, and how this shapes the net advance under
    selection. Our work suggests that even highly replicable substitutions may be
    associated with a range of selective effects, which makes it challenging to fine
    map the causal loci that underlie polygenic adaptation.
article_processing_charge: No
article_type: original
author:
- first_name: Himani
  full_name: Sachdeva, Himani
  id: 42377A0A-F248-11E8-B48F-1D18A9856A87
  last_name: Sachdeva
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Sachdeva H, Barton NH. Replicability of introgression under linked, polygenic
    selection. <i>Genetics</i>. 2018;210(4):1411-1427. doi:<a href="https://doi.org/10.1534/genetics.118.301429">10.1534/genetics.118.301429</a>
  apa: Sachdeva, H., &#38; Barton, N. H. (2018). Replicability of introgression under
    linked, polygenic selection. <i>Genetics</i>. Genetics Society of America. <a
    href="https://doi.org/10.1534/genetics.118.301429">https://doi.org/10.1534/genetics.118.301429</a>
  chicago: Sachdeva, Himani, and Nicholas H Barton. “Replicability of Introgression
    under Linked, Polygenic Selection.” <i>Genetics</i>. Genetics Society of America,
    2018. <a href="https://doi.org/10.1534/genetics.118.301429">https://doi.org/10.1534/genetics.118.301429</a>.
  ieee: H. Sachdeva and N. H. Barton, “Replicability of introgression under linked,
    polygenic selection,” <i>Genetics</i>, vol. 210, no. 4. Genetics Society of America,
    pp. 1411–1427, 2018.
  ista: Sachdeva H, Barton NH. 2018. Replicability of introgression under linked,
    polygenic selection. Genetics. 210(4), 1411–1427.
  mla: Sachdeva, Himani, and Nicholas H. Barton. “Replicability of Introgression under
    Linked, Polygenic Selection.” <i>Genetics</i>, vol. 210, no. 4, Genetics Society
    of America, 2018, pp. 1411–27, doi:<a href="https://doi.org/10.1534/genetics.118.301429">10.1534/genetics.118.301429</a>.
  short: H. Sachdeva, N.H. Barton, Genetics 210 (2018) 1411–1427.
date_created: 2018-12-11T11:44:18Z
date_published: 2018-12-04T00:00:00Z
date_updated: 2025-07-10T11:52:33Z
day: '04'
department:
- _id: NiBa
doi: 10.1534/genetics.118.301429
external_id:
  isi:
  - '000452315900021'
fulldoi: https://doi.org/10.1534/genetics.118.301429
intvolume: '       210'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.biorxiv.org/content/10.1101/379578v1
month: '12'
oa: 1
oa_version: Preprint
page: 1411-1427
publication: Genetics
publication_identifier:
  issn:
  - 0016-6731
publication_status: published
publisher: Genetics Society of America
quality_controlled: '1'
scopus_import: '1'
status: public
title: Replicability of introgression under linked, polygenic selection
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 210
year: '2018'
...
---
_id: '394'
abstract:
- lang: eng
  text: 'The valley pseudospin in monolayer transition metal dichalcogenides (TMDs)
    has been proposed as a new way to manipulate information in various optoelectronic
    devices. This relies on a large valley polarization that remains stable over long
    time scales (hundreds of nanoseconds). However, time-resolved measurements report
    valley lifetimes of only a few picoseconds. This has been attributed to mechanisms
    such as phonon-mediated intervalley scattering and a precession of the valley
    pseudospin through electron-hole exchange. Here we use transient spin grating
    to directly measure the valley depolarization lifetime in monolayer MoSe2. We
    find a fast valley decay rate that scales linearly with the excitation density
    at different temperatures. This establishes the presence of strong exciton-exciton
    Coulomb exchange interactions enhancing the valley depolarization. Our work highlights
    the microscopic processes inhibiting the efficient use of the exciton valley pseudospin
    in monolayer TMDs. '
arxiv: 1
author:
- first_name: Fahad
  full_name: Mahmood, Fahad
  last_name: Mahmood
- first_name: Zhanybek
  full_name: Alpichshev, Zhanybek
  id: 45E67A2A-F248-11E8-B48F-1D18A9856A87
  last_name: Alpichshev
  orcid: 0000-0002-7183-5203
- first_name: Yi
  full_name: Lee, Yi
  last_name: Lee
- first_name: Jing
  full_name: Kong, Jing
  last_name: Kong
- first_name: Nuh
  full_name: Gedik, Nuh
  last_name: Gedik
citation:
  ama: Mahmood F, Alpichshev Z, Lee Y, Kong J, Gedik N. Observation of exciton-exciton
    interaction mediated valley Depolarization in Monolayer MoSe2. <i>Nano Letters</i>.
    2018;18(1):223-228. doi:<a href="https://doi.org/10.1021/acs.nanolett.7b03953">10.1021/acs.nanolett.7b03953</a>
  apa: Mahmood, F., Alpichshev, Z., Lee, Y., Kong, J., &#38; Gedik, N. (2018). Observation
    of exciton-exciton interaction mediated valley Depolarization in Monolayer MoSe2.
    <i>Nano Letters</i>. American Chemical Society. <a href="https://doi.org/10.1021/acs.nanolett.7b03953">https://doi.org/10.1021/acs.nanolett.7b03953</a>
  chicago: Mahmood, Fahad, Zhanybek Alpichshev, Yi Lee, Jing Kong, and Nuh Gedik.
    “Observation of Exciton-Exciton Interaction Mediated Valley Depolarization in
    Monolayer MoSe2.” <i>Nano Letters</i>. American Chemical Society, 2018. <a href="https://doi.org/10.1021/acs.nanolett.7b03953">https://doi.org/10.1021/acs.nanolett.7b03953</a>.
  ieee: F. Mahmood, Z. Alpichshev, Y. Lee, J. Kong, and N. Gedik, “Observation of
    exciton-exciton interaction mediated valley Depolarization in Monolayer MoSe2,”
    <i>Nano Letters</i>, vol. 18, no. 1. American Chemical Society, pp. 223–228, 2018.
  ista: Mahmood F, Alpichshev Z, Lee Y, Kong J, Gedik N. 2018. Observation of exciton-exciton
    interaction mediated valley Depolarization in Monolayer MoSe2. Nano Letters. 18(1),
    223–228.
  mla: Mahmood, Fahad, et al. “Observation of Exciton-Exciton Interaction Mediated
    Valley Depolarization in Monolayer MoSe2.” <i>Nano Letters</i>, vol. 18, no. 1,
    American Chemical Society, 2018, pp. 223–28, doi:<a href="https://doi.org/10.1021/acs.nanolett.7b03953">10.1021/acs.nanolett.7b03953</a>.
  short: F. Mahmood, Z. Alpichshev, Y. Lee, J. Kong, N. Gedik, Nano Letters 18 (2018)
    223–228.
date_created: 2018-12-11T11:46:13Z
date_published: 2018-01-10T00:00:00Z
date_updated: 2021-01-12T07:53:20Z
day: '10'
doi: 10.1021/acs.nanolett.7b03953
extern: '1'
external_id:
  arxiv:
  - '1712.07925'
fulldoi: https://doi.org/10.1021/acs.nanolett.7b03953
intvolume: '        18'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1712.07925
month: '01'
oa: 1
oa_version: Submitted Version
page: 223 - 228
publication: Nano Letters
publication_status: published
publisher: American Chemical Society
publist_id: '7435'
quality_controlled: '1'
status: public
title: Observation of exciton-exciton interaction mediated valley Depolarization in
  Monolayer MoSe2
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 18
year: '2018'
...
---
_id: '397'
abstract:
- lang: eng
  text: 'Concurrent sets with range query operations are highly desirable in applications
    such as in-memory databases. However, few set implementations offer range queries.
    Known techniques for augmenting data structures with range queries (or operations
    that can be used to build range queries) have numerous problems that limit their
    usefulness. For example, they impose high overhead or rely heavily on garbage
    collection. In this work, we show how to augment data structures with highly efficient
    range queries, without relying on garbage collection. We identify a property of
    epoch-based memory reclamation algorithms that makes them ideal for implementing
    range queries, and produce three algorithms, which use locks, transactional memory
    and lock-free techniques, respectively. Our algorithms are applicable to more
    data structures than previous work, and are shown to be highly efficient on a
    large scale Intel system. '
alternative_title:
- PPoPP
article_processing_charge: No
author:
- first_name: Maya
  full_name: Arbel Raviv, Maya
  last_name: Arbel Raviv
- first_name: Trevor A
  full_name: Brown, Trevor A
  id: 3569F0A0-F248-11E8-B48F-1D18A9856A87
  last_name: Brown
citation:
  ama: 'Arbel Raviv M, Brown TA. Harnessing epoch-based reclamation for efficient
    range queries. In: Vol 53. ACM; 2018:14-27. doi:<a href="https://doi.org/10.1145/3178487.3178489">10.1145/3178487.3178489</a>'
  apa: 'Arbel Raviv, M., &#38; Brown, T. A. (2018). Harnessing epoch-based reclamation
    for efficient range queries (Vol. 53, pp. 14–27). Presented at the PPoPP: Principles
    and Practice of Parallel Programming, Vienna, Austria: ACM. <a href="https://doi.org/10.1145/3178487.3178489">https://doi.org/10.1145/3178487.3178489</a>'
  chicago: Arbel Raviv, Maya, and Trevor A Brown. “Harnessing Epoch-Based Reclamation
    for Efficient Range Queries,” 53:14–27. ACM, 2018. <a href="https://doi.org/10.1145/3178487.3178489">https://doi.org/10.1145/3178487.3178489</a>.
  ieee: 'M. Arbel Raviv and T. A. Brown, “Harnessing epoch-based reclamation for efficient
    range queries,” presented at the PPoPP: Principles and Practice of Parallel Programming,
    Vienna, Austria, 2018, vol. 53, no. 1, pp. 14–27.'
  ista: 'Arbel Raviv M, Brown TA. 2018. Harnessing epoch-based reclamation for efficient
    range queries. PPoPP: Principles and Practice of Parallel Programming, PPoPP,
    vol. 53, 14–27.'
  mla: Arbel Raviv, Maya, and Trevor A. Brown. <i>Harnessing Epoch-Based Reclamation
    for Efficient Range Queries</i>. Vol. 53, no. 1, ACM, 2018, pp. 14–27, doi:<a
    href="https://doi.org/10.1145/3178487.3178489">10.1145/3178487.3178489</a>.
  short: M. Arbel Raviv, T.A. Brown, in:, ACM, 2018, pp. 14–27.
conference:
  end_date: 2018-02-28
  location: Vienna, Austria
  name: 'PPoPP: Principles and Practice of Parallel Programming'
  start_date: 2018-02-24
date_created: 2018-12-11T11:46:14Z
date_published: 2018-02-10T00:00:00Z
date_updated: 2023-09-11T14:10:25Z
day: '10'
department:
- _id: DaAl
doi: 10.1145/3178487.3178489
external_id:
  isi:
  - '000446161100002'
fulldoi: https://doi.org/10.1145/3178487.3178489
intvolume: '        53'
isi: 1
issue: '1'
language:
- iso: eng
month: '02'
oa_version: None
page: 14 - 27
publication_identifier:
  isbn:
  - 978-1-4503-4982-6
publication_status: published
publisher: ACM
publist_id: '7430'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Harnessing epoch-based reclamation for efficient range queries
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 53
year: '2018'
...
---
_id: '398'
abstract:
- lang: eng
  text: 'Objective: To report long-term results after Pipeline Embolization Device
    (PED) implantation, characterize complex and standard aneurysms comprehensively,
    and introduce a modified flow disruption scale. Methods: We retrospectively reviewed
    a consecutive series of 40 patients harboring 59 aneurysms treated with 54 PEDs.
    Aneurysm complexity was assessed using our proposed classification. Immediate
    angiographic results were analyzed using previously published grading scales and
    our novel flow disruption scale. Results: According to our new definition, 46
    (78%) aneurysms were classified as complex. Most PED interventions were performed
    in the paraophthalmic and cavernous internal carotid artery segments. Excellent
    neurologic outcome (modified Rankin Scale 0 and 1) was observed in 94% of patients.
    Our data showed low permanent procedure-related mortality (0%) and morbidity (3%)
    rates. Long-term angiographic follow-up showed complete occlusion in 81% and near-total
    obliteration in a further 14%. Complete obliteration after deployment of a single
    PED was achieved in all standard aneurysms with 1-year follow-up. Our new scale
    was an independent predictor of aneurysm occlusion in a multivariable analysis.
    All aneurysms with a high flow disruption grade showed complete occlusion at follow-up
    regardless of PED number or aneurysm complexity. Conclusions: Treatment with the
    PED should be recognized as a primary management strategy for a highly selected
    cohort with predominantly complex intracranial aneurysms. We further show that
    a priori assessment of aneurysm complexity and our new postinterventional angiographic
    flow disruption scale predict occlusion probability and may help to determine
    the adequate number of per-aneurysm devices.'
article_processing_charge: No
author:
- first_name: Philippe
  full_name: Dodier, Philippe
  last_name: Dodier
- first_name: Josa
  full_name: Frischer, Josa
  last_name: Frischer
- first_name: Wei
  full_name: Wang, Wei
  last_name: Wang
- first_name: Thomas
  full_name: Auzinger, Thomas
  id: 4718F954-F248-11E8-B48F-1D18A9856A87
  last_name: Auzinger
  orcid: 0000-0002-1546-3265
- first_name: Ammar
  full_name: Mallouhi, Ammar
  last_name: Mallouhi
- first_name: Wolfgang
  full_name: Serles, Wolfgang
  last_name: Serles
- first_name: Andreas
  full_name: Gruber, Andreas
  last_name: Gruber
- first_name: Engelbert
  full_name: Knosp, Engelbert
  last_name: Knosp
- first_name: Gerhard
  full_name: Bavinzski, Gerhard
  last_name: Bavinzski
citation:
  ama: Dodier P, Frischer J, Wang W, et al. Immediate flow disruption as a prognostic
    factor after flow diverter treatment long term experience with the pipeline embolization
    device. <i>World Neurosurgery</i>. 2018;13:e568-e578. doi:<a href="https://doi.org/10.1016/j.wneu.2018.02.096">10.1016/j.wneu.2018.02.096</a>
  apa: Dodier, P., Frischer, J., Wang, W., Auzinger, T., Mallouhi, A., Serles, W.,
    … Bavinzski, G. (2018). Immediate flow disruption as a prognostic factor after
    flow diverter treatment long term experience with the pipeline embolization device.
    <i>World Neurosurgery</i>. Elsevier. <a href="https://doi.org/10.1016/j.wneu.2018.02.096">https://doi.org/10.1016/j.wneu.2018.02.096</a>
  chicago: Dodier, Philippe, Josa Frischer, Wei Wang, Thomas Auzinger, Ammar Mallouhi,
    Wolfgang Serles, Andreas Gruber, Engelbert Knosp, and Gerhard Bavinzski. “Immediate
    Flow Disruption as a Prognostic Factor after Flow Diverter Treatment Long Term
    Experience with the Pipeline Embolization Device.” <i>World Neurosurgery</i>.
    Elsevier, 2018. <a href="https://doi.org/10.1016/j.wneu.2018.02.096">https://doi.org/10.1016/j.wneu.2018.02.096</a>.
  ieee: P. Dodier <i>et al.</i>, “Immediate flow disruption as a prognostic factor
    after flow diverter treatment long term experience with the pipeline embolization
    device,” <i>World Neurosurgery</i>, vol. 13. Elsevier, pp. e568–e578, 2018.
  ista: Dodier P, Frischer J, Wang W, Auzinger T, Mallouhi A, Serles W, Gruber A,
    Knosp E, Bavinzski G. 2018. Immediate flow disruption as a prognostic factor after
    flow diverter treatment long term experience with the pipeline embolization device.
    World Neurosurgery. 13, e568–e578.
  mla: Dodier, Philippe, et al. “Immediate Flow Disruption as a Prognostic Factor
    after Flow Diverter Treatment Long Term Experience with the Pipeline Embolization
    Device.” <i>World Neurosurgery</i>, vol. 13, Elsevier, 2018, pp. e568–78, doi:<a
    href="https://doi.org/10.1016/j.wneu.2018.02.096">10.1016/j.wneu.2018.02.096</a>.
  short: P. Dodier, J. Frischer, W. Wang, T. Auzinger, A. Mallouhi, W. Serles, A.
    Gruber, E. Knosp, G. Bavinzski, World Neurosurgery 13 (2018) e568–e578.
date_created: 2018-12-11T11:46:15Z
date_published: 2018-05-01T00:00:00Z
date_updated: 2023-09-11T14:12:33Z
day: '01'
department:
- _id: BeBi
doi: 10.1016/j.wneu.2018.02.096
external_id:
  isi:
  - '000432942700070'
fulldoi: https://doi.org/10.1016/j.wneu.2018.02.096
intvolume: '        13'
isi: 1
language:
- iso: eng
month: '05'
oa_version: None
page: e568-e578
publication: World Neurosurgery
publication_status: published
publisher: Elsevier
publist_id: '7431'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Immediate flow disruption as a prognostic factor after flow diverter treatment
  long term experience with the pipeline embolization device
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 13
year: '2018'
...
---
_id: '399'
abstract:
- lang: eng
  text: Following an earlier calculation in 3D, we calculate the 2D critical temperature
    of a dilute, translation-invariant Bose gas using a variational formulation of
    the Bogoliubov approximation introduced by Critchley and Solomon in 1976. This
    provides the first analytical calculation of the Kosterlitz-Thouless transition
    temperature that includes the constant in the logarithm.
acknowledgement: We thank Robert Seiringer and Daniel Ueltschi for bringing the issue
  of the change in critical temperature to our attention. We also thank the Erwin
  Schrödinger Institute (all authors) and the Department of Mathematics, University
  of Copenhagen (MN) for the hospitality during the period this work was carried out.
  We gratefully acknowledge the financial support by the European Unions Seventh Framework
  Programme under the ERC Grant Agreement Nos. 321029 (JPS and RR) and 337603 (RR)
  as well as support by the VIL-LUM FONDEN via the QMATH Centre of Excellence (Grant
  No. 10059) (JPS and RR), by the National Science Center (NCN) under grant No. 2016/21/D/ST1/02430
  and the Austrian Science Fund (FWF) through project No. P 27533-N27 (MN).
article_number: '10007'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Marcin M
  full_name: Napiórkowski, Marcin M
  id: 4197AD04-F248-11E8-B48F-1D18A9856A87
  last_name: Napiórkowski
- first_name: Robin
  full_name: Reuvers, Robin
  last_name: Reuvers
- first_name: Jan
  full_name: Solovej, Jan
  last_name: Solovej
citation:
  ama: Napiórkowski MM, Reuvers R, Solovej J. Calculation of the critical temperature
    of a dilute Bose gas in the Bogoliubov approximation. <i>EPL</i>. 2018;121(1).
    doi:<a href="https://doi.org/10.1209/0295-5075/121/10007">10.1209/0295-5075/121/10007</a>
  apa: Napiórkowski, M. M., Reuvers, R., &#38; Solovej, J. (2018). Calculation of
    the critical temperature of a dilute Bose gas in the Bogoliubov approximation.
    <i>EPL</i>. IOP Publishing. <a href="https://doi.org/10.1209/0295-5075/121/10007">https://doi.org/10.1209/0295-5075/121/10007</a>
  chicago: Napiórkowski, Marcin M, Robin Reuvers, and Jan Solovej. “Calculation of
    the Critical Temperature of a Dilute Bose Gas in the Bogoliubov Approximation.”
    <i>EPL</i>. IOP Publishing, 2018. <a href="https://doi.org/10.1209/0295-5075/121/10007">https://doi.org/10.1209/0295-5075/121/10007</a>.
  ieee: M. M. Napiórkowski, R. Reuvers, and J. Solovej, “Calculation of the critical
    temperature of a dilute Bose gas in the Bogoliubov approximation,” <i>EPL</i>,
    vol. 121, no. 1. IOP Publishing, 2018.
  ista: Napiórkowski MM, Reuvers R, Solovej J. 2018. Calculation of the critical temperature
    of a dilute Bose gas in the Bogoliubov approximation. EPL. 121(1), 10007.
  mla: Napiórkowski, Marcin M., et al. “Calculation of the Critical Temperature of
    a Dilute Bose Gas in the Bogoliubov Approximation.” <i>EPL</i>, vol. 121, no.
    1, 10007, IOP Publishing, 2018, doi:<a href="https://doi.org/10.1209/0295-5075/121/10007">10.1209/0295-5075/121/10007</a>.
  short: M.M. Napiórkowski, R. Reuvers, J. Solovej, EPL 121 (2018).
date_created: 2018-12-11T11:46:15Z
date_published: 2018-01-01T00:00:00Z
date_updated: 2025-04-15T08:26:14Z
day: '01'
department:
- _id: RoSe
doi: 10.1209/0295-5075/121/10007
external_id:
  arxiv:
  - '1706.01822'
  isi:
  - '000460003000003'
fulldoi: https://doi.org/10.1209/0295-5075/121/10007
intvolume: '       121'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1706.01822
month: '01'
oa: 1
oa_version: Preprint
project:
- _id: 25C878CE-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P27533_N27
  name: Structure of the Excitation Spectrum for Many-Body Quantum Systems
publication: EPL
publication_status: published
publisher: IOP Publishing
publist_id: '7432'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Calculation of the critical temperature of a dilute Bose gas in the Bogoliubov
  approximation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 121
year: '2018'
...
---
_id: '40'
abstract:
- lang: eng
  text: Hanemaaijer et al. (Molecular Ecology, 27, 2018) describe the genetic consequences
    of the introgression of an insecticide resistance allele into a mosquito population.
    Linked alleles initially increased, but many of these later declined. It is hard
    to determine whether this decline was due to counter‐selection, rather than simply
    to chance.
article_processing_charge: Yes (via OA deal)
article_type: letter_note
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Barton NH. The consequences of an introgression event. <i>Molecular Ecology</i>.
    2018;27(24):4973-4975. doi:<a href="https://doi.org/10.1111/mec.14950">10.1111/mec.14950</a>
  apa: Barton, N. H. (2018). The consequences of an introgression event. <i>Molecular
    Ecology</i>. Wiley. <a href="https://doi.org/10.1111/mec.14950">https://doi.org/10.1111/mec.14950</a>
  chicago: Barton, Nicholas H. “The Consequences of an Introgression Event.” <i>Molecular
    Ecology</i>. Wiley, 2018. <a href="https://doi.org/10.1111/mec.14950">https://doi.org/10.1111/mec.14950</a>.
  ieee: N. H. Barton, “The consequences of an introgression event,” <i>Molecular Ecology</i>,
    vol. 27, no. 24. Wiley, pp. 4973–4975, 2018.
  ista: Barton NH. 2018. The consequences of an introgression event. Molecular Ecology.
    27(24), 4973–4975.
  mla: Barton, Nicholas H. “The Consequences of an Introgression Event.” <i>Molecular
    Ecology</i>, vol. 27, no. 24, Wiley, 2018, pp. 4973–75, doi:<a href="https://doi.org/10.1111/mec.14950">10.1111/mec.14950</a>.
  short: N.H. Barton, Molecular Ecology 27 (2018) 4973–4975.
corr_author: '1'
date_created: 2018-12-11T11:44:18Z
date_published: 2018-12-31T00:00:00Z
date_updated: 2025-07-10T11:52:34Z
day: '31'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1111/mec.14950
external_id:
  isi:
  - '000454600500001'
  pmid:
  - '30599087'
file:
- access_level: open_access
  content_type: application/pdf
  creator: apreinsp
  date_created: 2019-07-19T06:54:46Z
  date_updated: 2020-07-14T12:46:22Z
  file_id: '6652'
  file_name: 2018_MolecularEcology_BartonNick.pdf
  file_size: 295452
  relation: main_file
file_date_updated: 2020-07-14T12:46:22Z
fulldoi: https://doi.org/10.1111/mec.14950
has_accepted_license: '1'
intvolume: '        27'
isi: 1
issue: '24'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 4973-4975
pmid: 1
publication: Molecular Ecology
publication_identifier:
  issn:
  - 1365-294X
publication_status: published
publisher: Wiley
publist_id: '8014'
quality_controlled: '1'
related_material:
  record:
  - id: '9805'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: The consequences of an introgression event
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 27
year: '2018'
...
---
_id: '400'
abstract:
- lang: eng
  text: We consider the two-dimensional BCS functional with a radial pair interaction.
    We show that the translational symmetry is not broken in a certain temperature
    interval below the critical temperature. In the case of vanishing angular momentum,
    our results carry over to the three-dimensional case.
article_processing_charge: Yes (via OA deal)
author:
- first_name: Andreas
  full_name: Deuchert, Andreas
  id: 4DA65CD0-F248-11E8-B48F-1D18A9856A87
  last_name: Deuchert
  orcid: 0000-0003-3146-6746
- first_name: Alissa
  full_name: Geisinge, Alissa
  last_name: Geisinge
- first_name: Christian
  full_name: Hainzl, Christian
  last_name: Hainzl
- first_name: Michael
  full_name: Loss, Michael
  last_name: Loss
citation:
  ama: Deuchert A, Geisinge A, Hainzl C, Loss M. Persistence of translational symmetry
    in the BCS model with radial pair interaction. <i>Annales Henri Poincare</i>.
    2018;19(5):1507-1527. doi:<a href="https://doi.org/10.1007/s00023-018-0665-7">10.1007/s00023-018-0665-7</a>
  apa: Deuchert, A., Geisinge, A., Hainzl, C., &#38; Loss, M. (2018). Persistence
    of translational symmetry in the BCS model with radial pair interaction. <i>Annales
    Henri Poincare</i>. Springer. <a href="https://doi.org/10.1007/s00023-018-0665-7">https://doi.org/10.1007/s00023-018-0665-7</a>
  chicago: Deuchert, Andreas, Alissa Geisinge, Christian Hainzl, and Michael Loss.
    “Persistence of Translational Symmetry in the BCS Model with Radial Pair Interaction.”
    <i>Annales Henri Poincare</i>. Springer, 2018. <a href="https://doi.org/10.1007/s00023-018-0665-7">https://doi.org/10.1007/s00023-018-0665-7</a>.
  ieee: A. Deuchert, A. Geisinge, C. Hainzl, and M. Loss, “Persistence of translational
    symmetry in the BCS model with radial pair interaction,” <i>Annales Henri Poincare</i>,
    vol. 19, no. 5. Springer, pp. 1507–1527, 2018.
  ista: Deuchert A, Geisinge A, Hainzl C, Loss M. 2018. Persistence of translational
    symmetry in the BCS model with radial pair interaction. Annales Henri Poincare.
    19(5), 1507–1527.
  mla: Deuchert, Andreas, et al. “Persistence of Translational Symmetry in the BCS
    Model with Radial Pair Interaction.” <i>Annales Henri Poincare</i>, vol. 19, no.
    5, Springer, 2018, pp. 1507–27, doi:<a href="https://doi.org/10.1007/s00023-018-0665-7">10.1007/s00023-018-0665-7</a>.
  short: A. Deuchert, A. Geisinge, C. Hainzl, M. Loss, Annales Henri Poincare 19 (2018)
    1507–1527.
corr_author: '1'
date_created: 2018-12-11T11:46:15Z
date_published: 2018-05-01T00:00:00Z
date_updated: 2025-04-14T07:26:53Z
day: '01'
ddc:
- '510'
department:
- _id: RoSe
doi: 10.1007/s00023-018-0665-7
ec_funded: 1
external_id:
  isi:
  - '000429799900008'
file:
- access_level: open_access
  checksum: 04d2c9bd7cbf3ca1d7acaaf4e7dca3e5
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:12:47Z
  date_updated: 2020-07-14T12:46:22Z
  file_id: '4966'
  file_name: IST-2018-1011-v1+1_2018_Deuchert_Persistence.pdf
  file_size: 582680
  relation: main_file
file_date_updated: 2020-07-14T12:46:22Z
fulldoi: https://doi.org/10.1007/s00023-018-0665-7
has_accepted_license: '1'
intvolume: '        19'
isi: 1
issue: '5'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 1507 - 1527
project:
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '694227'
  name: Analysis of quantum many-body systems
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
  name: IST Austria Open Access Fund
publication: Annales Henri Poincare
publication_status: published
publisher: Springer
publist_id: '7429'
pubrep_id: '1011'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Persistence of translational symmetry in the BCS model with radial pair interaction
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 19
year: '2018'
...
---
_id: '401'
abstract:
- lang: eng
  text: The actomyosin cytoskeleton, a key stress-producing unit in epithelial cells,
    oscillates spontaneously in a wide variety of systems. Although much of the signal
    cascade regulating myosin activity has been characterized, the origin of such
    oscillatory behavior is still unclear. Here, we show that basal myosin II oscillation
    in Drosophila ovarian epithelium is not controlled by actomyosin cortical tension,
    but instead relies on a biochemical oscillator involving ROCK and myosin phosphatase.
    Key to this oscillation is a diffusive ROCK flow, linking junctional Rho1 to medial
    actomyosin cortex, and dynamically maintained by a self-activation loop reliant
    on ROCK kinase activity. In response to the resulting myosin II recruitment, myosin
    phosphatase is locally enriched and shuts off ROCK and myosin II signals. Coupling
    Drosophila genetics, live imaging, modeling, and optogenetics, we uncover an intrinsic
    biochemical oscillator at the core of myosin II regulatory network, shedding light
    on the spatio-temporal dynamics of force generation.
article_number: '1210'
article_processing_charge: No
author:
- first_name: Xiang
  full_name: Qin, Xiang
  last_name: Qin
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Thomas
  full_name: Mangeat, Thomas
  last_name: Mangeat
- first_name: Chang
  full_name: Liu, Chang
  last_name: Liu
- first_name: Pralay
  full_name: Majumder, Pralay
  last_name: Majumder
- first_name: Jjiaying
  full_name: Liu, Jjiaying
  last_name: Liu
- first_name: Valerie
  full_name: Choesmel Cadamuro, Valerie
  last_name: Choesmel Cadamuro
- first_name: Jocelyn
  full_name: Mcdonald, Jocelyn
  last_name: Mcdonald
- first_name: Yinyao
  full_name: Liu, Yinyao
  last_name: Liu
- first_name: Bin
  full_name: Yi, Bin
  last_name: Yi
- first_name: Xiaobo
  full_name: Wang, Xiaobo
  last_name: Wang
citation:
  ama: Qin X, Hannezo EB, Mangeat T, et al. A biochemical network controlling basal
    myosin oscillation. <i>Nature Communications</i>. 2018;9(1). doi:<a href="https://doi.org/10.1038/s41467-018-03574-5">10.1038/s41467-018-03574-5</a>
  apa: Qin, X., Hannezo, E. B., Mangeat, T., Liu, C., Majumder, P., Liu, J., … Wang,
    X. (2018). A biochemical network controlling basal myosin oscillation. <i>Nature
    Communications</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/s41467-018-03574-5">https://doi.org/10.1038/s41467-018-03574-5</a>
  chicago: Qin, Xiang, Edouard B Hannezo, Thomas Mangeat, Chang Liu, Pralay Majumder,
    Jjiaying Liu, Valerie Choesmel Cadamuro, et al. “A Biochemical Network Controlling
    Basal Myosin Oscillation.” <i>Nature Communications</i>. Nature Publishing Group,
    2018. <a href="https://doi.org/10.1038/s41467-018-03574-5">https://doi.org/10.1038/s41467-018-03574-5</a>.
  ieee: X. Qin <i>et al.</i>, “A biochemical network controlling basal myosin oscillation,”
    <i>Nature Communications</i>, vol. 9, no. 1. Nature Publishing Group, 2018.
  ista: Qin X, Hannezo EB, Mangeat T, Liu C, Majumder P, Liu J, Choesmel Cadamuro
    V, Mcdonald J, Liu Y, Yi B, Wang X. 2018. A biochemical network controlling basal
    myosin oscillation. Nature Communications. 9(1), 1210.
  mla: Qin, Xiang, et al. “A Biochemical Network Controlling Basal Myosin Oscillation.”
    <i>Nature Communications</i>, vol. 9, no. 1, 1210, Nature Publishing Group, 2018,
    doi:<a href="https://doi.org/10.1038/s41467-018-03574-5">10.1038/s41467-018-03574-5</a>.
  short: X. Qin, E.B. Hannezo, T. Mangeat, C. Liu, P. Majumder, J. Liu, V. Choesmel
    Cadamuro, J. Mcdonald, Y. Liu, B. Yi, X. Wang, Nature Communications 9 (2018).
date_created: 2018-12-11T11:46:16Z
date_published: 2018-03-23T00:00:00Z
date_updated: 2023-09-08T11:41:45Z
day: '23'
ddc:
- '539'
- '570'
department:
- _id: EdHa
doi: 10.1038/s41467-018-03574-5
external_id:
  isi:
  - '000428165400009'
file:
- access_level: open_access
  checksum: 87a427bc2e8724be3dd22a4efdd21a33
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:11:45Z
  date_updated: 2020-07-14T12:46:22Z
  file_id: '4902'
  file_name: IST-2018-996-v1+1_2018_Hannezo_A-biochemical.pdf
  file_size: 3780491
  relation: main_file
file_date_updated: 2020-07-14T12:46:22Z
fulldoi: https://doi.org/10.1038/s41467-018-03574-5
has_accepted_license: '1'
intvolume: '         9'
isi: 1
issue: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_status: published
publisher: Nature Publishing Group
publist_id: '7427'
pubrep_id: '996'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A biochemical network controlling basal myosin oscillation
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 9
year: '2018'
...
---
_id: '403'
abstract:
- lang: eng
  text: The ability to adapt growth and development to temperature variations is crucial
    to generate plant varieties resilient to predicted temperature changes. However,
    the mechanisms underlying plant response to progressive increases in temperature
    have just started to be elucidated. Here, we report that the Cyclin-dependent
    Kinase G1 (CDKG1) is a central element in a thermo-sensitive mRNA splicing cascade
    that transduces changes in ambient temperature into differential expression of
    the fundamental spliceosome component, ATU2AF65A. CDKG1 is alternatively spliced
    in a temperature-dependent manner. We found that this process is partly dependent
    on both the Cyclin-dependent Kinase G2 (CDKG2) and the interacting co-factor CYCLIN
    L1 resulting in two distinct messenger RNAs. Relative abundance of both CDKG1
    transcripts correlates with ambient temperature and possibly with different expression
    levels of the associated protein isoforms. Both CDKG1 alternative transcripts
    are necessary to fully complement the expression of ATU2AF65A across the temperature
    range. Our data support a previously unidentified temperature-dependent mechanism
    based on the alternative splicing of CDKG1 and regulated by CDKG2 and CYCLIN L1.
    We propose that changes in ambient temperature affect the relative abundance of
    CDKG1 transcripts and this in turn translates into differential CDKG1 protein
    expression coordinating the alternative splicing of ATU2AF65A. This article is
    protected by copyright. All rights reserved.
acknowledgement: CN, DD and JHD were funded by the BBSRC (grant number BB/M009459/1).
  NC was funded by the VIPS Program of the Austrian Federal Ministry of Science and
  Research and the City of Vienna. AB and AF were supported by the Austrian Science
  Fund (FWF) [DK W1207; SFB RNAreg F43-P10]
article_processing_charge: No
author:
- first_name: Nicola
  full_name: Cavallari, Nicola
  id: 457160E6-F248-11E8-B48F-1D18A9856A87
  last_name: Cavallari
- first_name: Candida
  full_name: Nibau, Candida
  last_name: Nibau
- first_name: Armin
  full_name: Fuchs, Armin
  last_name: Fuchs
- first_name: Despoina
  full_name: Dadarou, Despoina
  last_name: Dadarou
- first_name: Andrea
  full_name: Barta, Andrea
  last_name: Barta
- first_name: John
  full_name: Doonan, John
  last_name: Doonan
citation:
  ama: Cavallari N, Nibau C, Fuchs A, Dadarou D, Barta A, Doonan J. The cyclin‐dependent
    kinase G group defines a thermo‐sensitive alternative splicing circuit modulating
    the expression of Arabidopsis ATU 2AF 65A. <i>The Plant Journal</i>. 2018;94(6):1010-1022.
    doi:<a href="https://doi.org/10.1111/tpj.13914">10.1111/tpj.13914</a>
  apa: Cavallari, N., Nibau, C., Fuchs, A., Dadarou, D., Barta, A., &#38; Doonan,
    J. (2018). The cyclin‐dependent kinase G group defines a thermo‐sensitive alternative
    splicing circuit modulating the expression of Arabidopsis ATU 2AF 65A. <i>The
    Plant Journal</i>. Wiley. <a href="https://doi.org/10.1111/tpj.13914">https://doi.org/10.1111/tpj.13914</a>
  chicago: Cavallari, Nicola, Candida Nibau, Armin Fuchs, Despoina Dadarou, Andrea
    Barta, and John Doonan. “The Cyclin‐dependent Kinase G Group Defines a Thermo‐sensitive
    Alternative Splicing Circuit Modulating the Expression of Arabidopsis ATU 2AF
    65A.” <i>The Plant Journal</i>. Wiley, 2018. <a href="https://doi.org/10.1111/tpj.13914">https://doi.org/10.1111/tpj.13914</a>.
  ieee: N. Cavallari, C. Nibau, A. Fuchs, D. Dadarou, A. Barta, and J. Doonan, “The
    cyclin‐dependent kinase G group defines a thermo‐sensitive alternative splicing
    circuit modulating the expression of Arabidopsis ATU 2AF 65A,” <i>The Plant Journal</i>,
    vol. 94, no. 6. Wiley, pp. 1010–1022, 2018.
  ista: Cavallari N, Nibau C, Fuchs A, Dadarou D, Barta A, Doonan J. 2018. The cyclin‐dependent
    kinase G group defines a thermo‐sensitive alternative splicing circuit modulating
    the expression of Arabidopsis ATU 2AF 65A. The Plant Journal. 94(6), 1010–1022.
  mla: Cavallari, Nicola, et al. “The Cyclin‐dependent Kinase G Group Defines a Thermo‐sensitive
    Alternative Splicing Circuit Modulating the Expression of Arabidopsis ATU 2AF
    65A.” <i>The Plant Journal</i>, vol. 94, no. 6, Wiley, 2018, pp. 1010–22, doi:<a
    href="https://doi.org/10.1111/tpj.13914">10.1111/tpj.13914</a>.
  short: N. Cavallari, C. Nibau, A. Fuchs, D. Dadarou, A. Barta, J. Doonan, The Plant
    Journal 94 (2018) 1010–1022.
corr_author: '1'
date_created: 2018-12-11T11:46:17Z
date_published: 2018-06-01T00:00:00Z
date_updated: 2024-10-09T20:58:42Z
day: '01'
ddc:
- '580'
department:
- _id: EvBe
doi: 10.1111/tpj.13914
external_id:
  isi:
  - '000434365500008'
file:
- access_level: open_access
  checksum: d9d3ad3215ac0e581731443fca312266
  content_type: application/pdf
  creator: dernst
  date_created: 2019-02-06T11:40:54Z
  date_updated: 2020-07-14T12:46:22Z
  file_id: '5934'
  file_name: 2018_PlantJourn_Cavallari.pdf
  file_size: 1543354
  relation: main_file
file_date_updated: 2020-07-14T12:46:22Z
fulldoi: https://doi.org/10.1111/tpj.13914
has_accepted_license: '1'
intvolume: '        94'
isi: 1
issue: '6'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 1010 - 1022
publication: The Plant Journal
publication_status: published
publisher: Wiley
publist_id: '7426'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The cyclin‐dependent kinase G group defines a thermo‐sensitive alternative
  splicing circuit modulating the expression of Arabidopsis ATU 2AF 65A
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 94
year: '2018'
...
---
_id: '406'
abstract:
- lang: eng
  text: 'Recent developments in automated tracking allow uninterrupted, high-resolution
    recording of animal trajectories, sometimes coupled with the identification of
    stereotyped changes of body pose or other behaviors of interest. Analysis and
    interpretation of such data represents a challenge: the timing of animal behaviors
    may be stochastic and modulated by kinematic variables, by the interaction with
    the environment or with the conspecifics within the animal group, and dependent
    on internal cognitive or behavioral state of the individual. Existing models for
    collective motion typically fail to incorporate the discrete, stochastic, and
    internal-state-dependent aspects of behavior, while models focusing on individual
    animal behavior typically ignore the spatial aspects of the problem. Here we propose
    a probabilistic modeling framework to address this gap. Each animal can switch
    stochastically between different behavioral states, with each state resulting
    in a possibly different law of motion through space. Switching rates for behavioral
    transitions can depend in a very general way, which we seek to identify from data,
    on the effects of the environment as well as the interaction between the animals.
    We represent the switching dynamics as a Generalized Linear Model and show that:
    (i) forward simulation of multiple interacting animals is possible using a variant
    of the Gillespie’s Stochastic Simulation Algorithm; (ii) formulated properly,
    the maximum likelihood inference of switching rate functions is tractably solvable
    by gradient descent; (iii) model selection can be used to identify factors that
    modulate behavioral state switching and to appropriately adjust model complexity
    to data. To illustrate our framework, we apply it to two synthetic models of animal
    motion and to real zebrafish tracking data. '
acknowledgement: This work was supported by the Human Frontier Science Program RGP0065/2012
  (GT, ES).
article_processing_charge: Yes
author:
- first_name: Katarína
  full_name: Bod’Ová, Katarína
  last_name: Bod’Ová
- first_name: Gabriel
  full_name: Mitchell, Gabriel
  id: 315BCD80-F248-11E8-B48F-1D18A9856A87
  last_name: Mitchell
- first_name: Roy
  full_name: Harpaz, Roy
  last_name: Harpaz
- first_name: Elad
  full_name: Schneidman, Elad
  last_name: Schneidman
- first_name: Gasper
  full_name: Tkacik, Gasper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkacik
  orcid: 0000-0002-6699-1455
citation:
  ama: Bod’Ová K, Mitchell G, Harpaz R, Schneidman E, Tkačik G. Probabilistic models
    of individual and collective animal behavior. <i>PLoS One</i>. 2018;13(3). doi:<a
    href="https://doi.org/10.1371/journal.pone.0193049">10.1371/journal.pone.0193049</a>
  apa: Bod’Ová, K., Mitchell, G., Harpaz, R., Schneidman, E., &#38; Tkačik, G. (2018).
    Probabilistic models of individual and collective animal behavior. <i>PLoS One</i>.
    Public Library of Science. <a href="https://doi.org/10.1371/journal.pone.0193049">https://doi.org/10.1371/journal.pone.0193049</a>
  chicago: Bod’Ová, Katarína, Gabriel Mitchell, Roy Harpaz, Elad Schneidman, and Gašper
    Tkačik. “Probabilistic Models of Individual and Collective Animal Behavior.” <i>PLoS
    One</i>. Public Library of Science, 2018. <a href="https://doi.org/10.1371/journal.pone.0193049">https://doi.org/10.1371/journal.pone.0193049</a>.
  ieee: K. Bod’Ová, G. Mitchell, R. Harpaz, E. Schneidman, and G. Tkačik, “Probabilistic
    models of individual and collective animal behavior,” <i>PLoS One</i>, vol. 13,
    no. 3. Public Library of Science, 2018.
  ista: Bod’Ová K, Mitchell G, Harpaz R, Schneidman E, Tkačik G. 2018. Probabilistic
    models of individual and collective animal behavior. PLoS One. 13(3).
  mla: Bod’Ová, Katarína, et al. “Probabilistic Models of Individual and Collective
    Animal Behavior.” <i>PLoS One</i>, vol. 13, no. 3, Public Library of Science,
    2018, doi:<a href="https://doi.org/10.1371/journal.pone.0193049">10.1371/journal.pone.0193049</a>.
  short: K. Bod’Ová, G. Mitchell, R. Harpaz, E. Schneidman, G. Tkačik, PLoS One 13
    (2018).
corr_author: '1'
date_created: 2018-12-11T11:46:18Z
date_published: 2018-03-07T00:00:00Z
date_updated: 2025-04-15T06:44:30Z
day: '07'
ddc:
- '530'
- '571'
department:
- _id: GaTk
doi: 10.1371/journal.pone.0193049
external_id:
  isi:
  - '000426896800032'
file:
- access_level: open_access
  checksum: 684229493db75b43e98a46cd922da497
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:15:43Z
  date_updated: 2020-07-14T12:46:22Z
  file_id: '5165'
  file_name: IST-2018-995-v1+1_2018_Bodova_Probabilistic.pdf
  file_size: 6887358
  relation: main_file
file_date_updated: 2020-07-14T12:46:22Z
fulldoi: https://doi.org/10.1371/journal.pone.0193049
has_accepted_license: '1'
intvolume: '        13'
isi: 1
issue: '3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
project:
- _id: 255008E4-B435-11E9-9278-68D0E5697425
  grant_number: RGP0065/2012
  name: Information processing and computation in fish groups
publication: PLoS One
publication_status: published
publisher: Public Library of Science
publist_id: '7423'
pubrep_id: '995'
quality_controlled: '1'
related_material:
  record:
  - id: '9831'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Probabilistic models of individual and collective animal behavior
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 13
year: '2018'
...
---
_id: '407'
abstract:
- lang: eng
  text: Isoprenoid cytokinins play a number of crucial roles in the regulation of
    plant growth and development. To study cytokinin receptor properties in plants,
    we designed and prepared fluorescent derivatives of 6-[(3-methylbut-2-en-1-yl)amino]purine
    (N6-isopentenyladenine, iP) with several fluorescent labels attached to the C2
    or N9 atom of the purine moiety via a 2- or 6-carbon linker. The fluorescent labels
    included dansyl (DS), fluorescein (FC), 7-nitrobenzofurazan (NBD), rhodamine B
    (RhoB), coumarin (Cou), 7-(diethylamino)coumarin (DEAC) and cyanine 5 dye (Cy5).
    All prepared compounds were screened for affinity for the Arabidopsis thaliana
    cytokinin receptor (CRE1/AHK4). Although the attachment of the fluorescent labels
    to iP via the linkers mostly disrupted binding to the receptor, several fluorescent
    derivatives interacted well. For this reason, three derivatives, two rhodamine
    B and one 4-chloro-7-nitrobenzofurazan labeled iP were tested for their interaction
    with CRE1/AHK4 and Zea mays cytokinin receptors in detail. We further showed that
    the three derivatives were able to activate transcription of cytokinin response
    regulator ARR5 in Arabidopsis seedlings. The activity of fluorescently labeled
    cytokinins was compared with corresponding 6-dimethylaminopurine fluorescently
    labeled negative controls. Selected rhodamine B C2-labeled compounds 17, 18 and
    4-chloro-7-nitrobenzofurazan N9-labeled compound 28 and their respective negative
    controls (19, 20 and 29, respectively) were used for in planta staining experiments
    in Arabidopsis thaliana cell suspension culture using live cell confocal microscopy.
acknowledgement: "This work was supported by the Ministry of Education Youth and Sports,
  Czech Republic (grant LO1204 from the National Program of Sustainability I and Agricultural
  Research ) and by Czech Science Foundation grants 16-04184S , 501/10/1450 and 13-39982S
  and by IGA projects IGA_PrF_2018_033 and IGA_PrF_2018_023 . We would like to thank
  Jarmila Balonová, Olga Hustáková and Miroslava Šubová for their skillful technical
  assistance and Mgr. Tomáš Pospíšil, Ph.D. for his measurement of 1 H NMR and analysis
  of some 2D NMR spectral data. \r\n"
article_processing_charge: No
author:
- first_name: Karolina
  full_name: Kubiasová, Karolina
  last_name: Kubiasová
- first_name: Václav
  full_name: Mik, Václav
  last_name: Mik
- first_name: Jaroslav
  full_name: Nisler, Jaroslav
  last_name: Nisler
- first_name: Martin
  full_name: Hönig, Martin
  last_name: Hönig
- first_name: Alexandra
  full_name: Husičková, Alexandra
  last_name: Husičková
- first_name: Lukáš
  full_name: Spíchal, Lukáš
  last_name: Spíchal
- first_name: Zuzana
  full_name: Pěkná, Zuzana
  last_name: Pěkná
- first_name: Olga
  full_name: Šamajová, Olga
  last_name: Šamajová
- first_name: Karel
  full_name: Doležal, Karel
  last_name: Doležal
- first_name: Ondřej
  full_name: Plíhal, Ondřej
  last_name: Plíhal
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
- first_name: Miroslav
  full_name: Strnad, Miroslav
  last_name: Strnad
- first_name: Lucie
  full_name: Plíhalová, Lucie
  last_name: Plíhalová
citation:
  ama: Kubiasová K, Mik V, Nisler J, et al. Design, synthesis and perception of fluorescently
    labeled isoprenoid cytokinins. <i>Phytochemistry</i>. 2018;150:1-11. doi:<a href="https://doi.org/10.1016/j.phytochem.2018.02.015">10.1016/j.phytochem.2018.02.015</a>
  apa: Kubiasová, K., Mik, V., Nisler, J., Hönig, M., Husičková, A., Spíchal, L.,
    … Plíhalová, L. (2018). Design, synthesis and perception of fluorescently labeled
    isoprenoid cytokinins. <i>Phytochemistry</i>. Elsevier. <a href="https://doi.org/10.1016/j.phytochem.2018.02.015">https://doi.org/10.1016/j.phytochem.2018.02.015</a>
  chicago: Kubiasová, Karolina, Václav Mik, Jaroslav Nisler, Martin Hönig, Alexandra
    Husičková, Lukáš Spíchal, Zuzana Pěkná, et al. “Design, Synthesis and Perception
    of Fluorescently Labeled Isoprenoid Cytokinins.” <i>Phytochemistry</i>. Elsevier,
    2018. <a href="https://doi.org/10.1016/j.phytochem.2018.02.015">https://doi.org/10.1016/j.phytochem.2018.02.015</a>.
  ieee: K. Kubiasová <i>et al.</i>, “Design, synthesis and perception of fluorescently
    labeled isoprenoid cytokinins,” <i>Phytochemistry</i>, vol. 150. Elsevier, pp.
    1–11, 2018.
  ista: Kubiasová K, Mik V, Nisler J, Hönig M, Husičková A, Spíchal L, Pěkná Z, Šamajová
    O, Doležal K, Plíhal O, Benková E, Strnad M, Plíhalová L. 2018. Design, synthesis
    and perception of fluorescently labeled isoprenoid cytokinins. Phytochemistry.
    150, 1–11.
  mla: Kubiasová, Karolina, et al. “Design, Synthesis and Perception of Fluorescently
    Labeled Isoprenoid Cytokinins.” <i>Phytochemistry</i>, vol. 150, Elsevier, 2018,
    pp. 1–11, doi:<a href="https://doi.org/10.1016/j.phytochem.2018.02.015">10.1016/j.phytochem.2018.02.015</a>.
  short: K. Kubiasová, V. Mik, J. Nisler, M. Hönig, A. Husičková, L. Spíchal, Z. Pěkná,
    O. Šamajová, K. Doležal, O. Plíhal, E. Benková, M. Strnad, L. Plíhalová, Phytochemistry
    150 (2018) 1–11.
date_created: 2018-12-11T11:46:18Z
date_published: 2018-06-01T00:00:00Z
date_updated: 2023-09-11T12:53:11Z
day: '01'
department:
- _id: EvBe
doi: 10.1016/j.phytochem.2018.02.015
external_id:
  isi:
  - '000435623400001'
fulldoi: https://doi.org/10.1016/j.phytochem.2018.02.015
intvolume: '       150'
isi: 1
language:
- iso: eng
month: '06'
oa_version: None
page: 1-11
publication: Phytochemistry
publication_status: published
publisher: Elsevier
publist_id: '7422'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Design, synthesis and perception of fluorescently labeled isoprenoid cytokinins
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 150
year: '2018'
...
---
_id: '408'
abstract:
- lang: eng
  text: Adventitious roots (AR) are de novo formed roots that emerge from any part
    of the plant or from callus in tissue culture, except root tissue. The plant tissue
    origin and the method by which they are induced determine the physiological properties
    of emerged ARs. Hence, a standard method encompassing all types of AR does not
    exist. Here we describe a method for the induction and analysis of AR that emerge
    from the etiolated hypocotyl of dicot plants. The hypocotyl is formed during embryogenesis
    and shows a determined developmental pattern which usually does not involve AR
    formation. However, the hypocotyl shows propensity to form de novo roots under
    specific circumstances such as removal of the root system, high humidity or flooding,
    or during de-etiolation. The hypocotyl AR emerge from a pericycle-like cell layer
    surrounding the vascular tissue of the central cylinder, which is reminiscent
    to the developmental program of lateral roots. Here we propose an easy protocol
    for in vitro hypocotyl AR induction from etiolated Arabidopsis seedlings.
alternative_title:
- MIMB
article_processing_charge: No
author:
- first_name: Hoang
  full_name: Trinh, Hoang
  last_name: Trinh
- first_name: Inge
  full_name: Verstraeten, Inge
  id: 362BF7FE-F248-11E8-B48F-1D18A9856A87
  last_name: Verstraeten
  orcid: 0000-0001-7241-2328
- first_name: Danny
  full_name: Geelen, Danny
  last_name: Geelen
citation:
  ama: 'Trinh H, Verstraeten I, Geelen D. In vitro assay for induction of adventitious
    rooting on intact arabidopsis hypocotyls. In: <i>Root Development </i>. Vol 1761.
    Springer Nature; 2018:95-102. doi:<a href="https://doi.org/10.1007/978-1-4939-7747-5_7">10.1007/978-1-4939-7747-5_7</a>'
  apa: Trinh, H., Verstraeten, I., &#38; Geelen, D. (2018). In vitro assay for induction
    of adventitious rooting on intact arabidopsis hypocotyls. In <i>Root Development
    </i> (Vol. 1761, pp. 95–102). Springer Nature. <a href="https://doi.org/10.1007/978-1-4939-7747-5_7">https://doi.org/10.1007/978-1-4939-7747-5_7</a>
  chicago: Trinh, Hoang, Inge Verstraeten, and Danny Geelen. “In Vitro Assay for Induction
    of Adventitious Rooting on Intact Arabidopsis Hypocotyls.” In <i>Root Development
    </i>, 1761:95–102. Springer Nature, 2018. <a href="https://doi.org/10.1007/978-1-4939-7747-5_7">https://doi.org/10.1007/978-1-4939-7747-5_7</a>.
  ieee: H. Trinh, I. Verstraeten, and D. Geelen, “In vitro assay for induction of
    adventitious rooting on intact arabidopsis hypocotyls,” in <i>Root Development
    </i>, vol. 1761, Springer Nature, 2018, pp. 95–102.
  ista: 'Trinh H, Verstraeten I, Geelen D. 2018.In vitro assay for induction of adventitious
    rooting on intact arabidopsis hypocotyls. In: Root Development . MIMB, vol. 1761,
    95–102.'
  mla: Trinh, Hoang, et al. “In Vitro Assay for Induction of Adventitious Rooting
    on Intact Arabidopsis Hypocotyls.” <i>Root Development </i>, vol. 1761, Springer
    Nature, 2018, pp. 95–102, doi:<a href="https://doi.org/10.1007/978-1-4939-7747-5_7">10.1007/978-1-4939-7747-5_7</a>.
  short: H. Trinh, I. Verstraeten, D. Geelen, in:, Root Development , Springer Nature,
    2018, pp. 95–102.
date_created: 2018-12-11T11:46:18Z
date_published: 2018-03-01T00:00:00Z
date_updated: 2021-01-12T07:54:21Z
day: '01'
department:
- _id: JiFr
doi: 10.1007/978-1-4939-7747-5_7
external_id:
  pmid:
  - '29525951'
fulldoi: https://doi.org/10.1007/978-1-4939-7747-5_7
intvolume: '      1761'
language:
- iso: eng
month: '03'
oa_version: None
page: 95 - 102
pmid: 1
publication: 'Root Development '
publication_identifier:
  issn:
  - 1064-3745
publication_status: published
publisher: Springer Nature
publist_id: '7421'
quality_controlled: '1'
scopus_import: '1'
status: public
title: In vitro assay for induction of adventitious rooting on intact arabidopsis
  hypocotyls
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1761
year: '2018'
...
---
_id: '409'
abstract:
- lang: eng
  text: We give a simple proof of T. Stehling's result [4], whereby in any normal
    tiling of the plane with convex polygons with number of sides not less than six,
    all tiles except a finite number are hexagons.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Arseniy
  full_name: Akopyan, Arseniy
  id: 430D2C90-F248-11E8-B48F-1D18A9856A87
  last_name: Akopyan
  orcid: 0000-0002-2548-617X
citation:
  ama: Akopyan A. On the number of non-hexagons in a planar tiling. <i>Comptes Rendus
    Mathematique</i>. 2018;356(4):412-414. doi:<a href="https://doi.org/10.1016/j.crma.2018.03.005">10.1016/j.crma.2018.03.005</a>
  apa: Akopyan, A. (2018). On the number of non-hexagons in a planar tiling. <i>Comptes
    Rendus Mathematique</i>. Elsevier. <a href="https://doi.org/10.1016/j.crma.2018.03.005">https://doi.org/10.1016/j.crma.2018.03.005</a>
  chicago: Akopyan, Arseniy. “On the Number of Non-Hexagons in a Planar Tiling.” <i>Comptes
    Rendus Mathematique</i>. Elsevier, 2018. <a href="https://doi.org/10.1016/j.crma.2018.03.005">https://doi.org/10.1016/j.crma.2018.03.005</a>.
  ieee: A. Akopyan, “On the number of non-hexagons in a planar tiling,” <i>Comptes
    Rendus Mathematique</i>, vol. 356, no. 4. Elsevier, pp. 412–414, 2018.
  ista: Akopyan A. 2018. On the number of non-hexagons in a planar tiling. Comptes
    Rendus Mathematique. 356(4), 412–414.
  mla: Akopyan, Arseniy. “On the Number of Non-Hexagons in a Planar Tiling.” <i>Comptes
    Rendus Mathematique</i>, vol. 356, no. 4, Elsevier, 2018, pp. 412–14, doi:<a href="https://doi.org/10.1016/j.crma.2018.03.005">10.1016/j.crma.2018.03.005</a>.
  short: A. Akopyan, Comptes Rendus Mathematique 356 (2018) 412–414.
corr_author: '1'
date_created: 2018-12-11T11:46:19Z
date_published: 2018-04-01T00:00:00Z
date_updated: 2025-07-10T11:52:35Z
day: '01'
department:
- _id: HeEd
doi: 10.1016/j.crma.2018.03.005
external_id:
  arxiv:
  - '1805.01652'
  isi:
  - '000430402700009'
fulldoi: https://doi.org/10.1016/j.crma.2018.03.005
intvolume: '       356'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1805.01652
month: '04'
oa: 1
oa_version: Preprint
page: 412-414
publication: Comptes Rendus Mathematique
publication_identifier:
  issn:
  - 1631-073X
publication_status: published
publisher: Elsevier
publist_id: '7420'
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the number of non-hexagons in a planar tiling
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 356
year: '2018'
...
---
_id: '41'
abstract:
- lang: eng
  text: 'The small-conductance, Ca2+-activated K+ (SK) channel subtype SK2 regulates
    the spike rate and firing frequency, as well as Ca2+ transients in Purkinje cells
    (PCs). To understand the molecular basis by which SK2 channels mediate these functions,
    we analyzed the exact location and densities of SK2 channels along the neuronal
    surface of the mouse cerebellar PCs using SDS-digested freeze-fracture replica
    labeling (SDS-FRL) of high sensitivity combined with quantitative analyses. Immunogold
    particles for SK2 were observed on post- and pre-synaptic compartments showing
    both scattered and clustered distribution patterns. We found an axo-somato-dendritic
    gradient of the SK2 particle density increasing 12-fold from soma to dendritic
    spines. Using two different immunogold approaches, we also found that SK2 immunoparticles
    were frequently adjacent to, but never overlap with, the postsynaptic density
    of excitatory synapses in PC spines. Co-immunoprecipitation analysis demonstrated
    that SK2 channels form macromolecular complexes with two types of proteins that
    mobilize Ca2+: CaV2.1 channels and mGlu1α receptors in the cerebellum. Freeze-fracture
    replica double-labeling showed significant co-clustering of particles for SK2
    with those for CaV2.1 channels and mGlu1α receptors. SK2 channels were also detected
    at presynaptic sites, mostly at the presynaptic active zone (AZ), where they are
    close to CaV2.1 channels, though they are not significantly co-clustered. These
    data demonstrate that SK2 channels located in different neuronal compartments
    can associate with distinct proteins mobilizing Ca2+, and suggest that the ultrastructural
    association of SK2 with CaV2.1 and mGlu1α provides the mechanism that ensures
    voltage (excitability) regulation by distinct intracellular Ca2+ transients in
    PCs.'
article_number: '311'
article_processing_charge: No
article_type: original
author:
- first_name: Rafæl
  full_name: Luján, Rafæl
  last_name: Luján
- first_name: Carolina
  full_name: Aguado, Carolina
  last_name: Aguado
- first_name: Francisco
  full_name: Ciruela, Francisco
  last_name: Ciruela
- first_name: Xavier
  full_name: Arus, Xavier
  last_name: Arus
- first_name: Alejandro
  full_name: Martín Belmonte, Alejandro
  last_name: Martín Belmonte
- first_name: Rocío
  full_name: Alfaro Ruiz, Rocío
  last_name: Alfaro Ruiz
- first_name: Jesus
  full_name: Martinez Gomez, Jesus
  last_name: Martinez Gomez
- first_name: Luis
  full_name: De La Ossa, Luis
  last_name: De La Ossa
- first_name: Masahiko
  full_name: Watanabe, Masahiko
  last_name: Watanabe
- first_name: John
  full_name: Adelman, John
  last_name: Adelman
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Yugo
  full_name: Fukazawa, Yugo
  last_name: Fukazawa
citation:
  ama: Luján R, Aguado C, Ciruela F, et al. Sk2 channels associate with mGlu1α receptors
    and CaV2.1 channels in Purkinje cells. <i>Frontiers in Cellular Neuroscience</i>.
    2018;12. doi:<a href="https://doi.org/10.3389/fncel.2018.00311">10.3389/fncel.2018.00311</a>
  apa: Luján, R., Aguado, C., Ciruela, F., Arus, X., Martín Belmonte, A., Alfaro Ruiz,
    R., … Fukazawa, Y. (2018). Sk2 channels associate with mGlu1α receptors and CaV2.1
    channels in Purkinje cells. <i>Frontiers in Cellular Neuroscience</i>. Frontiers
    Media. <a href="https://doi.org/10.3389/fncel.2018.00311">https://doi.org/10.3389/fncel.2018.00311</a>
  chicago: Luján, Rafæl, Carolina Aguado, Francisco Ciruela, Xavier Arus, Alejandro
    Martín Belmonte, Rocío Alfaro Ruiz, Jesus Martinez Gomez, et al. “Sk2 Channels
    Associate with MGlu1α Receptors and CaV2.1 Channels in Purkinje Cells.” <i>Frontiers
    in Cellular Neuroscience</i>. Frontiers Media, 2018. <a href="https://doi.org/10.3389/fncel.2018.00311">https://doi.org/10.3389/fncel.2018.00311</a>.
  ieee: R. Luján <i>et al.</i>, “Sk2 channels associate with mGlu1α receptors and
    CaV2.1 channels in Purkinje cells,” <i>Frontiers in Cellular Neuroscience</i>,
    vol. 12. Frontiers Media, 2018.
  ista: Luján R, Aguado C, Ciruela F, Arus X, Martín Belmonte A, Alfaro Ruiz R, Martinez
    Gomez J, De La Ossa L, Watanabe M, Adelman J, Shigemoto R, Fukazawa Y. 2018. Sk2
    channels associate with mGlu1α receptors and CaV2.1 channels in Purkinje cells.
    Frontiers in Cellular Neuroscience. 12, 311.
  mla: Luján, Rafæl, et al. “Sk2 Channels Associate with MGlu1α Receptors and CaV2.1
    Channels in Purkinje Cells.” <i>Frontiers in Cellular Neuroscience</i>, vol. 12,
    311, Frontiers Media, 2018, doi:<a href="https://doi.org/10.3389/fncel.2018.00311">10.3389/fncel.2018.00311</a>.
  short: R. Luján, C. Aguado, F. Ciruela, X. Arus, A. Martín Belmonte, R. Alfaro Ruiz,
    J. Martinez Gomez, L. De La Ossa, M. Watanabe, J. Adelman, R. Shigemoto, Y. Fukazawa,
    Frontiers in Cellular Neuroscience 12 (2018).
date_created: 2018-12-11T11:44:19Z
date_published: 2018-09-19T00:00:00Z
date_updated: 2025-07-10T11:52:35Z
day: '19'
ddc:
- '570'
department:
- _id: RySh
doi: 10.3389/fncel.2018.00311
ec_funded: 1
external_id:
  isi:
  - '000445090100002'
file:
- access_level: open_access
  checksum: 0bcaec8d596162af0b7fe3f31325d480
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T08:49:03Z
  date_updated: 2020-07-14T12:46:23Z
  file_id: '5684'
  file_name: fncel-12-00311.pdf
  file_size: 6834251
  relation: main_file
file_date_updated: 2020-07-14T12:46:23Z
fulldoi: https://doi.org/10.3389/fncel.2018.00311
has_accepted_license: '1'
intvolume: '        12'
isi: 1
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
project:
- _id: 25CBA828-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '720270'
  name: Human Brain Project Specific Grant Agreement 1
publication: Frontiers in Cellular Neuroscience
publication_identifier:
  issn:
  - 1662-5102
publication_status: published
publisher: Frontiers Media
publist_id: '8013'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sk2 channels associate with mGlu1α receptors and CaV2.1 channels in Purkinje
  cells
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2018'
...
---
_id: '410'
abstract:
- lang: eng
  text: Lesion verification and quantification is traditionally done via histological
    examination of sectioned brains, a time-consuming process that relies heavily
    on manual estimation. Such methods are particularly problematic in posterior cortical
    regions (e.g. visual cortex), where sectioning leads to significant damage and
    distortion of tissue. Even more challenging is the post hoc localization of micro-electrodes,
    which relies on the same techniques, suffers from similar drawbacks and requires
    even higher precision. Here, we propose a new, simple method for quantitative
    lesion characterization and electrode localization that is less labor-intensive
    and yields more detailed results than conventional methods. We leverage staining
    techniques standard in electron microscopy with the use of commodity micro-CT
    imaging. We stain whole rat and zebra finch brains in osmium tetroxide, embed
    these in resin and scan entire brains in a micro-CT machine. The scans result
    in 3D reconstructions of the brains with section thickness dependent on sample
    size (12–15 and 5–6 microns for rat and zebra finch respectively) that can be
    segmented manually or automatically. Because the method captures the entire intact
    brain volume, comparisons within and across studies are more tractable, and the
    extent of lesions and electrodes may be studied with higher accuracy than with
    current methods.
article_number: '5184'
article_processing_charge: No
author:
- first_name: Javier
  full_name: Masís, Javier
  last_name: Masís
- first_name: David
  full_name: Mankus, David
  last_name: Mankus
- first_name: Steffen
  full_name: Wolff, Steffen
  last_name: Wolff
- first_name: Grigori
  full_name: Guitchounts, Grigori
  last_name: Guitchounts
- first_name: Maximilian A
  full_name: Jösch, Maximilian A
  id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
  last_name: Jösch
  orcid: 0000-0002-3937-1330
- first_name: David
  full_name: Cox, David
  last_name: Cox
citation:
  ama: Masís J, Mankus D, Wolff S, Guitchounts G, Jösch MA, Cox D. A micro-CT-based
    method for quantitative brain lesion characterization and electrode localization.
    <i>Scientific Reports</i>. 2018;8(1). doi:<a href="https://doi.org/10.1038/s41598-018-23247-z">10.1038/s41598-018-23247-z</a>
  apa: Masís, J., Mankus, D., Wolff, S., Guitchounts, G., Jösch, M. A., &#38; Cox,
    D. (2018). A micro-CT-based method for quantitative brain lesion characterization
    and electrode localization. <i>Scientific Reports</i>. Nature Publishing Group.
    <a href="https://doi.org/10.1038/s41598-018-23247-z">https://doi.org/10.1038/s41598-018-23247-z</a>
  chicago: Masís, Javier, David Mankus, Steffen Wolff, Grigori Guitchounts, Maximilian
    A Jösch, and David Cox. “A Micro-CT-Based Method for Quantitative Brain Lesion
    Characterization and Electrode Localization.” <i>Scientific Reports</i>. Nature
    Publishing Group, 2018. <a href="https://doi.org/10.1038/s41598-018-23247-z">https://doi.org/10.1038/s41598-018-23247-z</a>.
  ieee: J. Masís, D. Mankus, S. Wolff, G. Guitchounts, M. A. Jösch, and D. Cox, “A
    micro-CT-based method for quantitative brain lesion characterization and electrode
    localization,” <i>Scientific Reports</i>, vol. 8, no. 1. Nature Publishing Group,
    2018.
  ista: Masís J, Mankus D, Wolff S, Guitchounts G, Jösch MA, Cox D. 2018. A micro-CT-based
    method for quantitative brain lesion characterization and electrode localization.
    Scientific Reports. 8(1), 5184.
  mla: Masís, Javier, et al. “A Micro-CT-Based Method for Quantitative Brain Lesion
    Characterization and Electrode Localization.” <i>Scientific Reports</i>, vol.
    8, no. 1, 5184, Nature Publishing Group, 2018, doi:<a href="https://doi.org/10.1038/s41598-018-23247-z">10.1038/s41598-018-23247-z</a>.
  short: J. Masís, D. Mankus, S. Wolff, G. Guitchounts, M.A. Jösch, D. Cox, Scientific
    Reports 8 (2018).
date_created: 2018-12-11T11:46:19Z
date_published: 2018-03-26T00:00:00Z
date_updated: 2023-09-08T11:48:39Z
day: '26'
ddc:
- '571'
- '572'
department:
- _id: MaJö
doi: 10.1038/s41598-018-23247-z
external_id:
  isi:
  - '000428234100005'
file:
- access_level: open_access
  checksum: 653fcb852f899c75b00ceee2a670d738
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:10:42Z
  date_updated: 2020-07-14T12:46:23Z
  file_id: '4831'
  file_name: IST-2018-994-v1+1_2018_Joesch_A-micro-CT-based.pdf
  file_size: 2359430
  relation: main_file
file_date_updated: 2020-07-14T12:46:23Z
fulldoi: https://doi.org/10.1038/s41598-018-23247-z
has_accepted_license: '1'
intvolume: '         8'
isi: 1
issue: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: Scientific Reports
publication_status: published
publisher: Nature Publishing Group
publist_id: '7419'
pubrep_id: '994'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A micro-CT-based method for quantitative brain lesion characterization and
  electrode localization
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 8
year: '2018'
...
