--- OA_place: repository OA_type: green _id: '22052' abstract: - lang: eng text: 'We consider the focusing cubic nonlinear Schrödinger equation (NLS) in the exterior Ω of a smooth, compact, strictly convex obstacle in three dimensions. We prove that the threshold for global existence and scattering is the same as for the problem posed on Euclidean space. Specifically, we prove that if E(u0)M(u0)Applied Mathematics Research eXpress. 2016;2016(1):146-180. doi:10.1093/amrx/abv012 apa: Killip, R., Vişan, M., & Zhang, X. (2016). The focusing cubic NLS on exterior domains in three dimensions. Applied Mathematics Research EXpress. Oxford University Press. https://doi.org/10.1093/amrx/abv012 chicago: Killip, Rowan, Monica Vişan, and Xiaoyi Zhang. “The Focusing Cubic NLS on Exterior Domains in Three Dimensions.” Applied Mathematics Research EXpress. Oxford University Press, 2016. https://doi.org/10.1093/amrx/abv012. ieee: R. Killip, M. Vişan, and X. Zhang, “The focusing cubic NLS on exterior domains in three dimensions,” Applied Mathematics Research eXpress, vol. 2016, no. 1. Oxford University Press, pp. 146–180, 2016. ista: Killip R, Vişan M, Zhang X. 2016. The focusing cubic NLS on exterior domains in three dimensions. Applied Mathematics Research eXpress. 2016(1), 146–180. mla: Killip, Rowan, et al. “The Focusing Cubic NLS on Exterior Domains in Three Dimensions.” Applied Mathematics Research EXpress, vol. 2016, no. 1, Oxford University Press, 2016, pp. 146–80, doi:10.1093/amrx/abv012. short: R. Killip, M. Vişan, X. Zhang, Applied Mathematics Research EXpress 2016 (2016) 146–180. das_tickbox: '1' date_created: 2026-06-19T07:54:24Z date_published: 2016-01-01T00:00:00Z date_updated: 2026-06-25T08:30:19Z day: '01' doi: 10.1093/amrx/abv012 extern: '1' external_id: arxiv: - '1501.05062' intvolume: ' 2016' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.1501.05062 month: '01' oa: 1 oa_version: Preprint page: 146-180 publication: Applied Mathematics Research eXpress publication_identifier: eissn: - 1687-1197 issn: - 1687-1200 publication_status: published publisher: Oxford University Press quality_controlled: '1' scopus_import: '1' status: public title: The focusing cubic NLS on exterior domains in three dimensions type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 2016 year: '2016' ... --- _id: '1100' abstract: - lang: eng text: During metazoan development, the temporal pattern of morphogen signaling is critical for organizing cell fates in space and time. Yet, tools for temporally controlling morphogen signaling within the embryo are still scarce. Here, we developed a photoactivatable Nodal receptor to determine how the temporal pattern of Nodal signaling affects cell fate specification during zebrafish gastrulation. By using this receptor to manipulate the duration of Nodal signaling in vivo by light, we show that extended Nodal signaling within the organizer promotes prechordal plate specification and suppresses endoderm differentiation. Endoderm differentiation is suppressed by extended Nodal signaling inducing expression of the transcriptional repressor goosecoid (gsc) in prechordal plate progenitors, which in turn restrains Nodal signaling from upregulating the endoderm differentiation gene sox17 within these cells. Thus, optogenetic manipulation of Nodal signaling identifies a critical role of Nodal signaling duration for organizer cell fate specification during gastrulation. acknowledged_ssus: - _id: SSU acknowledgement: 'We are grateful to members of the C.-P.H. and H.J. labs for discussions, R. Hauschild and the different Scientific Service Units at IST Austria for technical help, M. Dravecka for performing initial experiments, A. Schier for reading an earlier version of the manuscript, K.W. Rogers for technical help, and C. Hill, A. Bruce, and L. Solnica-Krezel for sending plasmids. This work was supported by grants from the Austrian Science Foundation (FWF): (T560-B17) and (I 812-B12) to V.R. and C.-P.H., and from the European Union (EU FP7): (6275) to H.J. A.I.-P. is supported by a Ramon Areces fellowship.' article_processing_charge: No author: - first_name: Keisuke full_name: Sako, Keisuke id: 3BED66BE-F248-11E8-B48F-1D18A9856A87 last_name: Sako orcid: 0000-0002-6453-8075 - first_name: Saurabh full_name: Pradhan, Saurabh last_name: Pradhan - first_name: Vanessa full_name: Barone, Vanessa id: 419EECCC-F248-11E8-B48F-1D18A9856A87 last_name: Barone orcid: 0000-0003-2676-3367 - first_name: Álvaro full_name: Inglés Prieto, Álvaro id: 2A9DB292-F248-11E8-B48F-1D18A9856A87 last_name: Inglés Prieto orcid: 0000-0002-5409-8571 - first_name: Patrick full_name: Mueller, Patrick last_name: Mueller - first_name: Verena full_name: Ruprecht, Verena id: 4D71A03A-F248-11E8-B48F-1D18A9856A87 last_name: Ruprecht orcid: 0000-0003-4088-8633 - first_name: Daniel full_name: Capek, Daniel id: 31C42484-F248-11E8-B48F-1D18A9856A87 last_name: Capek orcid: 0000-0001-5199-9940 - first_name: Sanjeev full_name: Galande, Sanjeev last_name: Galande - first_name: Harald L full_name: Janovjak, Harald L id: 33BA6C30-F248-11E8-B48F-1D18A9856A87 last_name: Janovjak orcid: 0000-0002-8023-9315 - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 citation: ama: Sako K, Pradhan S, Barone V, et al. Optogenetic control of nodal signaling reveals a temporal pattern of nodal signaling regulating cell fate specification during gastrulation. Cell Reports. 2016;16(3):866-877. doi:10.1016/j.celrep.2016.06.036 apa: Sako, K., Pradhan, S., Barone, V., Inglés Prieto, Á., Mueller, P., Ruprecht, V., … Heisenberg, C.-P. J. (2016). Optogenetic control of nodal signaling reveals a temporal pattern of nodal signaling regulating cell fate specification during gastrulation. Cell Reports. Cell Press. https://doi.org/10.1016/j.celrep.2016.06.036 chicago: Sako, Keisuke, Saurabh Pradhan, Vanessa Barone, Álvaro Inglés Prieto, Patrick Mueller, Verena Ruprecht, Daniel Capek, Sanjeev Galande, Harald L Janovjak, and Carl-Philipp J Heisenberg. “Optogenetic Control of Nodal Signaling Reveals a Temporal Pattern of Nodal Signaling Regulating Cell Fate Specification during Gastrulation.” Cell Reports. Cell Press, 2016. https://doi.org/10.1016/j.celrep.2016.06.036. ieee: K. Sako et al., “Optogenetic control of nodal signaling reveals a temporal pattern of nodal signaling regulating cell fate specification during gastrulation,” Cell Reports, vol. 16, no. 3. Cell Press, pp. 866–877, 2016. ista: Sako K, Pradhan S, Barone V, Inglés Prieto Á, Mueller P, Ruprecht V, Capek D, Galande S, Janovjak HL, Heisenberg C-PJ. 2016. Optogenetic control of nodal signaling reveals a temporal pattern of nodal signaling regulating cell fate specification during gastrulation. Cell Reports. 16(3), 866–877. mla: Sako, Keisuke, et al. “Optogenetic Control of Nodal Signaling Reveals a Temporal Pattern of Nodal Signaling Regulating Cell Fate Specification during Gastrulation.” Cell Reports, vol. 16, no. 3, Cell Press, 2016, pp. 866–77, doi:10.1016/j.celrep.2016.06.036. short: K. Sako, S. Pradhan, V. Barone, Á. Inglés Prieto, P. Mueller, V. Ruprecht, D. Capek, S. Galande, H.L. Janovjak, C.-P.J. Heisenberg, Cell Reports 16 (2016) 866–877. date_created: 2018-12-11T11:50:08Z date_published: 2016-07-19T00:00:00Z date_updated: 2026-06-26T22:32:02Z day: '19' ddc: - '570' - '576' department: - _id: CaHe - _id: HaJa doi: 10.1016/j.celrep.2016.06.036 ec_funded: 1 external_id: isi: - '000380264200024' file: - access_level: open_access content_type: application/pdf creator: system date_created: 2018-12-12T10:11:04Z date_updated: 2018-12-12T10:11:04Z file_id: '4857' file_name: IST-2017-754-v1+1_1-s2.0-S2211124716307768-main.pdf file_size: 3921947 relation: main_file file_date_updated: 2018-12-12T10:11:04Z has_accepted_license: '1' intvolume: ' 16' isi: 1 issue: '3' language: - iso: eng month: '07' oa: 1 oa_version: Published Version page: 866 - 877 project: - _id: 2529486C-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: T 560-B17 name: Cell- and Tissue Mechanics in Zebrafish Germ Layer Formation - _id: 2527D5CC-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: I812-B12 name: Cell Cortex and Germ Layer Formation in Zebrafish Gastrulation - _id: 25548C20-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '303564' name: Microbial Ion Channels for Synthetic Neurobiology publication: Cell Reports publication_status: published publisher: Cell Press publist_id: '6275' pubrep_id: '754' quality_controlled: '1' related_material: record: - id: '961' relation: dissertation_contains status: public - id: '50' relation: dissertation_contains status: public scopus_import: '1' status: public title: Optogenetic control of nodal signaling reveals a temporal pattern of nodal signaling regulating cell fate specification during gastrulation tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 16 year: '2016' ... --- _id: '1321' abstract: - lang: eng text: Most migrating cells extrude their front by the force of actin polymerization. Polymerization requires an initial nucleation step, which is mediated by factors establishing either parallel filaments in the case of filopodia or branched filaments that form the branched lamellipodial network. Branches are considered essential for regular cell motility and are initiated by the Arp2/3 complex, which in turn is activated by nucleation-promoting factors of the WASP and WAVE families. Here we employed rapid amoeboid crawling leukocytes and found that deletion of the WAVE complex eliminated actin branching and thus lamellipodia formation. The cells were left with parallel filaments at the leading edge, which translated, depending on the differentiation status of the cell, into a unipolar pointed cell shape or cells with multiple filopodia. Remarkably, unipolar cells migrated with increased speed and enormous directional persistence, while they were unable to turn towards chemotactic gradients. Cells with multiple filopodia retained chemotactic activity but their migration was progressively impaired with increasing geometrical complexity of the extracellular environment. These findings establish that diversified leading edge protrusions serve as explorative structures while they slow down actual locomotion. acknowledged_ssus: - _id: SSU acknowledgement: "This work was supported by the German Research Foundation (DFG) Priority Program SP 1464 to T.E.B.S. and M.S., and European Research Council (ERC GA 281556) and Human Frontiers Program grants to M.S.\r\nService Units of IST Austria for excellent technical support." article_processing_charge: No article_type: original author: - first_name: Alexander F full_name: Leithner, Alexander F id: 3B1B77E4-F248-11E8-B48F-1D18A9856A87 last_name: Leithner orcid: 0000-0002-1073-744X - first_name: Alexander full_name: Eichner, Alexander id: 4DFA52AE-F248-11E8-B48F-1D18A9856A87 last_name: Eichner - first_name: Jan full_name: Müller, Jan id: AD07FDB4-0F61-11EA-8158-C4CC64CEAA8D last_name: Müller - first_name: Anne full_name: Reversat, Anne id: 35B76592-F248-11E8-B48F-1D18A9856A87 last_name: Reversat orcid: 0000-0003-0666-8928 - first_name: Markus full_name: Brown, Markus id: 3DAB9AFC-F248-11E8-B48F-1D18A9856A87 last_name: Brown - first_name: Jan full_name: Schwarz, Jan id: 346C1EC6-F248-11E8-B48F-1D18A9856A87 last_name: Schwarz - first_name: Jack full_name: Merrin, Jack id: 4515C308-F248-11E8-B48F-1D18A9856A87 last_name: Merrin orcid: 0000-0001-5145-4609 - first_name: David full_name: De Gorter, David last_name: De Gorter - first_name: Florian full_name: Schur, Florian id: 48AD8942-F248-11E8-B48F-1D18A9856A87 last_name: Schur orcid: 0000-0003-4790-8078 - first_name: Jonathan full_name: Bayerl, Jonathan last_name: Bayerl - first_name: Ingrid full_name: De Vries, Ingrid id: 4C7D837E-F248-11E8-B48F-1D18A9856A87 last_name: De Vries - first_name: Stefan full_name: Wieser, Stefan id: 355AA5A0-F248-11E8-B48F-1D18A9856A87 last_name: Wieser orcid: 0000-0002-2670-2217 - first_name: Robert full_name: Hauschild, Robert id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87 last_name: Hauschild orcid: 0000-0001-9843-3522 - first_name: Frank full_name: Lai, Frank last_name: Lai - first_name: Markus full_name: Moser, Markus last_name: Moser - first_name: Dontscho full_name: Kerjaschki, Dontscho last_name: Kerjaschki - first_name: Klemens full_name: Rottner, Klemens last_name: Rottner - first_name: Victor full_name: Small, Victor last_name: Small - first_name: Theresia full_name: Stradal, Theresia last_name: Stradal - first_name: Michael K full_name: Sixt, Michael K id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87 last_name: Sixt orcid: 0000-0002-6620-9179 citation: ama: Leithner AF, Eichner A, Müller J, et al. Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes. Nature Cell Biology. 2016;18:1253-1259. doi:10.1038/ncb3426 apa: Leithner, A. F., Eichner, A., Müller, J., Reversat, A., Brown, M., Schwarz, J., … Sixt, M. K. (2016). Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes. Nature Cell Biology. Nature Publishing Group. https://doi.org/10.1038/ncb3426 chicago: Leithner, Alexander F, Alexander Eichner, Jan Müller, Anne Reversat, Markus Brown, Jan Schwarz, Jack Merrin, et al. “Diversified Actin Protrusions Promote Environmental Exploration but Are Dispensable for Locomotion of Leukocytes.” Nature Cell Biology. Nature Publishing Group, 2016. https://doi.org/10.1038/ncb3426. ieee: A. F. Leithner et al., “Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes,” Nature Cell Biology, vol. 18. Nature Publishing Group, pp. 1253–1259, 2016. ista: Leithner AF, Eichner A, Müller J, Reversat A, Brown M, Schwarz J, Merrin J, De Gorter D, Schur FK, Bayerl J, de Vries I, Wieser S, Hauschild R, Lai F, Moser M, Kerjaschki D, Rottner K, Small V, Stradal T, Sixt MK. 2016. Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes. Nature Cell Biology. 18, 1253–1259. mla: Leithner, Alexander F., et al. “Diversified Actin Protrusions Promote Environmental Exploration but Are Dispensable for Locomotion of Leukocytes.” Nature Cell Biology, vol. 18, Nature Publishing Group, 2016, pp. 1253–59, doi:10.1038/ncb3426. short: A.F. Leithner, A. Eichner, J. Müller, A. Reversat, M. Brown, J. Schwarz, J. Merrin, D. De Gorter, F.K. Schur, J. Bayerl, I. de Vries, S. Wieser, R. Hauschild, F. Lai, M. Moser, D. Kerjaschki, K. Rottner, V. Small, T. Stradal, M.K. Sixt, Nature Cell Biology 18 (2016) 1253–1259. corr_author: '1' date_created: 2018-12-11T11:51:21Z date_published: 2016-10-24T00:00:00Z date_updated: 2026-06-26T22:33:04Z day: '24' ddc: - '570' department: - _id: MiSi - _id: NanoFab - _id: Bio doi: 10.1038/ncb3426 ec_funded: 1 external_id: isi: - '000387165600018' file: - access_level: open_access checksum: e1411cb7c99a2d9089c178a6abef25e7 content_type: application/pdf creator: dernst date_created: 2020-05-14T16:33:46Z date_updated: 2020-07-14T12:44:43Z file_id: '7844' file_name: 2018_NatureCell_Leithner.pdf file_size: 4433280 relation: main_file file_date_updated: 2020-07-14T12:44:43Z has_accepted_license: '1' intvolume: ' 18' isi: 1 language: - iso: eng month: '10' oa: 1 oa_version: Submitted Version page: 1253 - 1259 project: - _id: 25A603A2-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '281556' name: Cytoskeletal force generation and force transduction of migrating leukocytes publication: Nature Cell Biology publication_status: published publisher: Nature Publishing Group publist_id: '5949' quality_controlled: '1' related_material: record: - id: '323' relation: dissertation_contains status: public scopus_import: '1' status: public title: Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes tmp: image: /images/cc_by_nc_sa.png legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) short: CC BY-NC-SA (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 18 year: '2016' ... --- _id: '1183' abstract: - lang: eng text: Autism spectrum disorders (ASD) are a group of genetic disorders often overlapping with other neurological conditions. We previously described abnormalities in the branched-chain amino acid (BCAA) catabolic pathway as a cause of ASD. Here, we show that the solute carrier transporter 7a5 (SLC7A5), a large neutral amino acid transporter localized at the blood brain barrier (BBB), has an essential role in maintaining normal levels of brain BCAAs. In mice, deletion of Slc7a5 from the endothelial cells of the BBB leads to atypical brain amino acid profile, abnormal mRNA translation, and severe neurological abnormalities. Furthermore, we identified several patients with autistic traits and motor delay carrying deleterious homozygous mutations in the SLC7A5 gene. Finally, we demonstrate that BCAA intracerebroventricular administration ameliorates abnormal behaviors in adult mutant mice. Our data elucidate a neurological syndrome defined by SLC7A5 mutations and support an essential role for the BCAA in human brain function. acknowledgement: "This work was supported by NICHD (P01HD070494) and SFARI (grant 275275) to J.G.G., and FWF (SFB35_3523) to G.N.\r\nWe thank A.C. Manzano, Mike Liu, and F. Marr for technical assistance, and R. Shigemoto and the IST Austria Electron Microscopy (EM) Facility for assistance. We acknowledge support from CIDR for genome-wide SNP analysis (X01HG008823) and Broad Institute Center for Mendelian Disorders (UM1HG008900 to D. MacArthur), the Yale Center for Mendelian Disorders (U54HG006504 to M.G.), the Gregory M. Kiez and Mehmet Kutman Foundation (M.G.), Italian Ministry of Instruction University and Research (PON01_00937 to C.I.), and NIH (R01-GM108911 to A.S.). This work was supported by NICHD (P01HD070494) and SFARI (grant 275275) to J.G.G., and FWF (SFB35_3523) to G.N.\r\n\r\n#EMFacility" article_processing_charge: No article_type: original author: - first_name: Dora-Clara full_name: Tarlungeanu, Dora-Clara id: 2ABCE612-F248-11E8-B48F-1D18A9856A87 last_name: Tarlungeanu - first_name: Elena full_name: Deliu, Elena id: 37A40D7E-F248-11E8-B48F-1D18A9856A87 last_name: Deliu orcid: 0000-0002-7370-5293 - first_name: Christoph full_name: Dotter, Christoph id: 4C66542E-F248-11E8-B48F-1D18A9856A87 last_name: Dotter orcid: 0000-0002-9033-9096 - first_name: Majdi full_name: Kara, Majdi last_name: Kara - first_name: Philipp full_name: Janiesch, Philipp last_name: Janiesch - first_name: Mariafrancesca full_name: Scalise, Mariafrancesca last_name: Scalise - first_name: Michele full_name: Galluccio, Michele last_name: Galluccio - first_name: Mateja full_name: Tesulov, Mateja last_name: Tesulov - first_name: Emanuela full_name: Morelli, Emanuela id: 3F4D1282-F248-11E8-B48F-1D18A9856A87 last_name: Morelli - first_name: Fatma full_name: Sönmez, Fatma last_name: Sönmez - first_name: Kaya full_name: Bilgüvar, Kaya last_name: Bilgüvar - first_name: Ryuichi full_name: Ohgaki, Ryuichi last_name: Ohgaki - first_name: Yoshikatsu full_name: Kanai, Yoshikatsu last_name: Kanai - first_name: Anide full_name: Johansen, Anide last_name: Johansen - first_name: Seham full_name: Esharif, Seham last_name: Esharif - first_name: Tawfeg full_name: Ben Omran, Tawfeg last_name: Ben Omran - first_name: Meral full_name: Topcu, Meral last_name: Topcu - first_name: Avner full_name: Schlessinger, Avner last_name: Schlessinger - first_name: Cesare full_name: Indiveri, Cesare last_name: Indiveri - first_name: Kent full_name: Duncan, Kent last_name: Duncan - first_name: Ahmet full_name: Caglayan, Ahmet last_name: Caglayan - first_name: Murat full_name: Günel, Murat last_name: Günel - first_name: Joseph full_name: Gleeson, Joseph last_name: Gleeson - first_name: Gaia full_name: Novarino, Gaia id: 3E57A680-F248-11E8-B48F-1D18A9856A87 last_name: Novarino orcid: 0000-0002-7673-7178 citation: ama: Tarlungeanu D-C, Deliu E, Dotter C, et al. Impaired amino acid transport at the blood brain barrier is a cause of autism spectrum disorder. Cell. 2016;167(6):1481-1494. doi:10.1016/j.cell.2016.11.013 apa: Tarlungeanu, D.-C., Deliu, E., Dotter, C., Kara, M., Janiesch, P., Scalise, M., … Novarino, G. (2016). Impaired amino acid transport at the blood brain barrier is a cause of autism spectrum disorder. Cell. Cell Press. https://doi.org/10.1016/j.cell.2016.11.013 chicago: Tarlungeanu, Dora-Clara, Elena Deliu, Christoph Dotter, Majdi Kara, Philipp Janiesch, Mariafrancesca Scalise, Michele Galluccio, et al. “Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder.” Cell. Cell Press, 2016. https://doi.org/10.1016/j.cell.2016.11.013. ieee: D.-C. Tarlungeanu et al., “Impaired amino acid transport at the blood brain barrier is a cause of autism spectrum disorder,” Cell, vol. 167, no. 6. Cell Press, pp. 1481–1494, 2016. ista: Tarlungeanu D-C, Deliu E, Dotter C, Kara M, Janiesch P, Scalise M, Galluccio M, Tesulov M, Morelli E, Sönmez F, Bilgüvar K, Ohgaki R, Kanai Y, Johansen A, Esharif S, Ben Omran T, Topcu M, Schlessinger A, Indiveri C, Duncan K, Caglayan A, Günel M, Gleeson J, Novarino G. 2016. Impaired amino acid transport at the blood brain barrier is a cause of autism spectrum disorder. Cell. 167(6), 1481–1494. mla: Tarlungeanu, Dora-Clara, et al. “Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder.” Cell, vol. 167, no. 6, Cell Press, 2016, pp. 1481–94, doi:10.1016/j.cell.2016.11.013. short: D.-C. Tarlungeanu, E. Deliu, C. Dotter, M. Kara, P. Janiesch, M. Scalise, M. Galluccio, M. Tesulov, E. Morelli, F. Sönmez, K. Bilgüvar, R. Ohgaki, Y. Kanai, A. Johansen, S. Esharif, T. Ben Omran, M. Topcu, A. Schlessinger, C. Indiveri, K. Duncan, A. Caglayan, M. Günel, J. Gleeson, G. Novarino, Cell 167 (2016) 1481–1494. date_created: 2018-12-11T11:50:35Z date_published: 2016-12-01T00:00:00Z date_updated: 2026-06-26T22:33:01Z day: '01' ddc: - '576' - '616' department: - _id: GaNo doi: 10.1016/j.cell.2016.11.013 external_id: isi: - '000389470500012' file: - access_level: open_access checksum: 7fe01ab12a6610d3db421e0136db2f77 content_type: application/pdf creator: system date_created: 2018-12-12T10:13:44Z date_updated: 2020-07-14T12:44:37Z file_id: '5030' file_name: IST-2017-771-v1+1_Tarlungeanu_et_al._Final_edited.pdf file_size: 73907957 relation: main_file file_date_updated: 2020-07-14T12:44:37Z has_accepted_license: '1' intvolume: ' 167' isi: 1 issue: '6' language: - iso: eng month: '12' oa: 1 oa_version: Submitted Version page: 1481 - 1494 project: - _id: 25473368-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: F03523 name: Transmembrane Transporters in Health and Disease publication: Cell publication_status: published publisher: Cell Press publist_id: '6170' pubrep_id: '771' quality_controlled: '1' related_material: record: - id: '395' relation: dissertation_contains status: public scopus_import: '1' status: public title: Impaired amino acid transport at the blood brain barrier is a cause of autism spectrum disorder type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 167 year: '2016' ... --- _id: '1437' abstract: - lang: eng text: We study algorithmic questions for concurrent systems where the transitions are labeled from a complete, closed semiring, and path properties are algebraic with semiring operations. The algebraic path properties can model dataflow analysis problems, the shortest path problem, and many other natural problems that arise in program analysis. We consider that each component of the concurrent system is a graph with constant treewidth, a property satisfied by the controlflow graphs of most programs. We allow for multiple possible queries, which arise naturally in demand driven dataflow analysis. The study of multiple queries allows us to consider the tradeoff between the resource usage of the one-time preprocessing and for each individual query. The traditional approach constructs the product graph of all components and applies the best-known graph algorithm on the product. In this approach, even the answer to a single query requires the transitive closure (i.e., the results of all possible queries), which provides no room for tradeoff between preprocessing and query time. Our main contributions are algorithms that significantly improve the worst-case running time of the traditional approach, and provide various tradeoffs depending on the number of queries. For example, in a concurrent system of two components, the traditional approach requires hexic time in the worst case for answering one query as well as computing the transitive closure, whereas we show that with one-time preprocessing in almost cubic time, each subsequent query can be answered in at most linear time, and even the transitive closure can be computed in almost quartic time. Furthermore, we establish conditional optimality results showing that the worst-case running time of our algorithms cannot be improved without achieving major breakthroughs in graph algorithms (i.e., improving the worst-case bound for the shortest path problem in general graphs). Preliminary experimental results show that our algorithms perform favorably on several benchmarks. alternative_title: - POPL arxiv: 1 author: - first_name: Krishnendu full_name: Chatterjee, Krishnendu id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87 last_name: Chatterjee orcid: 0000-0002-4561-241X - first_name: Amir full_name: Goharshady, Amir id: 391365CE-F248-11E8-B48F-1D18A9856A87 last_name: Goharshady orcid: 0000-0003-1702-6584 - first_name: Rasmus full_name: Ibsen-Jensen, Rasmus id: 3B699956-F248-11E8-B48F-1D18A9856A87 last_name: Ibsen-Jensen orcid: 0000-0003-4783-0389 - first_name: Andreas full_name: Pavlogiannis, Andreas id: 49704004-F248-11E8-B48F-1D18A9856A87 last_name: Pavlogiannis orcid: 0000-0002-8943-0722 citation: ama: 'Chatterjee K, Goharshady AK, Ibsen-Jensen R, Pavlogiannis A. Algorithms for algebraic path properties in concurrent systems of constant treewidth components. In: Vol 20-22. ACM; 2016:733-747. doi:10.1145/2837614.2837624' apa: 'Chatterjee, K., Goharshady, A. K., Ibsen-Jensen, R., & Pavlogiannis, A. (2016). Algorithms for algebraic path properties in concurrent systems of constant treewidth components (Vol. 20–22, pp. 733–747). Presented at the POPL: Principles of Programming Languages, St. Petersburg, FL, USA: ACM. https://doi.org/10.1145/2837614.2837624' chicago: Chatterjee, Krishnendu, Amir Kafshdar Goharshady, Rasmus Ibsen-Jensen, and Andreas Pavlogiannis. “Algorithms for Algebraic Path Properties in Concurrent Systems of Constant Treewidth Components,” 20–22:733–47. ACM, 2016. https://doi.org/10.1145/2837614.2837624. ieee: 'K. Chatterjee, A. K. Goharshady, R. Ibsen-Jensen, and A. Pavlogiannis, “Algorithms for algebraic path properties in concurrent systems of constant treewidth components,” presented at the POPL: Principles of Programming Languages, St. Petersburg, FL, USA, 2016, vol. 20–22, pp. 733–747.' ista: 'Chatterjee K, Goharshady AK, Ibsen-Jensen R, Pavlogiannis A. 2016. Algorithms for algebraic path properties in concurrent systems of constant treewidth components. POPL: Principles of Programming Languages, POPL, vol. 20–22, 733–747.' mla: Chatterjee, Krishnendu, et al. Algorithms for Algebraic Path Properties in Concurrent Systems of Constant Treewidth Components. Vol. 20–22, ACM, 2016, pp. 733–47, doi:10.1145/2837614.2837624. short: K. Chatterjee, A.K. Goharshady, R. Ibsen-Jensen, A. Pavlogiannis, in:, ACM, 2016, pp. 733–747. conference: end_date: 2016-01-22 location: St. Petersburg, FL, USA name: 'POPL: Principles of Programming Languages' start_date: 2016-01-20 corr_author: '1' date_created: 2018-12-11T11:52:01Z date_published: 2016-01-11T00:00:00Z date_updated: 2026-06-26T22:34:25Z day: '11' department: - _id: KrCh doi: 10.1145/2837614.2837624 ec_funded: 1 external_id: arxiv: - '1510.07565' language: - iso: eng main_file_link: - open_access: '1' url: http://arxiv.org/abs/1510.07565 month: '01' oa: 1 oa_version: Preprint page: 733 - 747 project: - _id: 25832EC2-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: S 11407_N23 name: Rigorous Systems Engineering - _id: 2581B60A-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '279307' name: 'Quantitative Graph Games: Theory and Applications' publication_status: published publisher: ACM publist_id: '5761' quality_controlled: '1' related_material: record: - id: '5441' relation: earlier_version status: public - id: '5442' relation: earlier_version status: public - id: '6009' relation: later_version status: public - id: '821' relation: dissertation_contains status: public - id: '8934' relation: dissertation_contains status: public scopus_import: 1 status: public title: Algorithms for algebraic path properties in concurrent systems of constant treewidth components type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 20-22 year: '2016' ... --- _id: '1386' abstract: - lang: eng text: We consider nondeterministic probabilistic programs with the most basic liveness property of termination. We present efficient methods for termination analysis of nondeterministic probabilistic programs with polynomial guards and assignments. Our approach is through synthesis of polynomial ranking supermartingales, that on one hand significantly generalizes linear ranking supermartingales and on the other hand is a counterpart of polynomial ranking-functions for proving termination of nonprobabilistic programs. The approach synthesizes polynomial ranking-supermartingales through Positivstellensatz's, yielding an efficient method which is not only sound, but also semi-complete over a large subclass of programs. We show experimental results to demonstrate that our approach can handle several classical programs with complex polynomial guards and assignments, and can synthesize efficient quadratic ranking-supermartingales when a linear one does not exist even for simple affine programs. alternative_title: - LNCS article_processing_charge: No arxiv: 1 author: - first_name: Krishnendu full_name: Chatterjee, Krishnendu id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87 last_name: Chatterjee orcid: 0000-0002-4561-241X - first_name: Hongfei full_name: Fu, Hongfei id: 3AAD03D6-F248-11E8-B48F-1D18A9856A87 last_name: Fu - first_name: Amir full_name: Goharshady, Amir id: 391365CE-F248-11E8-B48F-1D18A9856A87 last_name: Goharshady orcid: 0000-0003-1702-6584 citation: ama: 'Chatterjee K, Fu H, Goharshady AK. Termination analysis of probabilistic programs through Positivstellensatz’s. In: Vol 9779. Springer; 2016:3-22. doi:10.1007/978-3-319-41528-4_1' apa: 'Chatterjee, K., Fu, H., & Goharshady, A. K. (2016). Termination analysis of probabilistic programs through Positivstellensatz’s (Vol. 9779, pp. 3–22). Presented at the CAV: Computer Aided Verification, Toronto, Canada: Springer. https://doi.org/10.1007/978-3-319-41528-4_1' chicago: Chatterjee, Krishnendu, Hongfei Fu, and Amir Kafshdar Goharshady. “Termination Analysis of Probabilistic Programs through Positivstellensatz’s,” 9779:3–22. Springer, 2016. https://doi.org/10.1007/978-3-319-41528-4_1. ieee: 'K. Chatterjee, H. Fu, and A. K. Goharshady, “Termination analysis of probabilistic programs through Positivstellensatz’s,” presented at the CAV: Computer Aided Verification, Toronto, Canada, 2016, vol. 9779, pp. 3–22.' ista: 'Chatterjee K, Fu H, Goharshady AK. 2016. Termination analysis of probabilistic programs through Positivstellensatz’s. CAV: Computer Aided Verification, LNCS, vol. 9779, 3–22.' mla: Chatterjee, Krishnendu, et al. Termination Analysis of Probabilistic Programs through Positivstellensatz’s. Vol. 9779, Springer, 2016, pp. 3–22, doi:10.1007/978-3-319-41528-4_1. short: K. Chatterjee, H. Fu, A.K. Goharshady, in:, Springer, 2016, pp. 3–22. conference: end_date: 2016-07-23 location: Toronto, Canada name: 'CAV: Computer Aided Verification' start_date: 2016-07-17 corr_author: '1' date_created: 2018-12-11T11:51:43Z date_published: 2016-07-01T00:00:00Z date_updated: 2026-06-26T22:34:26Z day: '01' department: - _id: KrCh doi: 10.1007/978-3-319-41528-4_1 ec_funded: 1 external_id: arxiv: - '1604.07169' isi: - '000387731200001' intvolume: ' 9779' isi: 1 language: - iso: eng main_file_link: - open_access: '1' url: http://arxiv.org/abs/1604.07169 month: '07' oa: 1 oa_version: Preprint page: 3 - 22 project: - _id: 25832EC2-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: S 11407_N23 name: Rigorous Systems Engineering - _id: 2581B60A-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '279307' name: 'Quantitative Graph Games: Theory and Applications' - _id: 25EE3708-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '267989' name: Quantitative Reactive Modeling publication_status: published publisher: Springer publist_id: '5824' quality_controlled: '1' related_material: record: - id: '8934' relation: dissertation_contains status: public scopus_import: '1' status: public title: Termination analysis of probabilistic programs through Positivstellensatz's type: conference user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 9779 year: '2016' ... --- _id: '1106' abstract: - lang: eng text: Circumferential skin creases Kunze type (CSC-KT) is a specific congenital entity with an unknown genetic cause. The disease phenotype comprises characteristic circumferential skin creases accompanied by intellectual disability, a cleft palate, short stature, and dysmorphic features. Here, we report that mutations in either MAPRE2 or TUBB underlie the genetic origin of this syndrome. MAPRE2 encodes a member of the microtubule end-binding family of proteins that bind to the guanosine triphosphate cap at growing microtubule plus ends, and TUBB encodes a β-tubulin isotype that is expressed abundantly in the developing brain. Functional analyses of the TUBB mutants show multiple defects in the chaperone-dependent tubulin heterodimer folding and assembly pathway that leads to a compromised yield of native heterodimers. The TUBB mutations also have an impact on microtubule dynamics. For MAPRE2, we show that the mutations result in enhanced MAPRE2 binding to microtubules, implying an increased dwell time at microtubule plus ends. Further, in vivo analysis of MAPRE2 mutations in a zebrafish model of craniofacial development shows that the variants most likely perturb the patterning of branchial arches, either through excessive activity (under a recessive paradigm) or through haploinsufficiency (dominant de novo paradigm). Taken together, our data add CSC-KT to the growing list of tubulinopathies and highlight how multiple inheritance paradigms can affect dosage-sensitive biological systems so as to result in the same clinical defect. article_processing_charge: No author: - first_name: Mala full_name: Isrie, Mala last_name: Isrie - first_name: Martin full_name: Breuss, Martin last_name: Breuss - first_name: Guoling full_name: Tian, Guoling last_name: Tian - first_name: Andi H full_name: Hansen, Andi H id: 38853E16-F248-11E8-B48F-1D18A9856A87 last_name: Hansen - first_name: Francesca full_name: Cristofoli, Francesca last_name: Cristofoli - first_name: Jasmin full_name: Morandell, Jasmin id: 4739D480-F248-11E8-B48F-1D18A9856A87 last_name: Morandell - first_name: Zachari A full_name: Kupchinsky, Zachari A last_name: Kupchinsky - first_name: Alejandro full_name: Sifrim, Alejandro last_name: Sifrim - first_name: Celia full_name: Rodriguez Rodriguez, Celia last_name: Rodriguez Rodriguez - first_name: Elena P full_name: Dapena, Elena P last_name: Dapena - first_name: Kurston full_name: Doonanco, Kurston last_name: Doonanco - first_name: Norma full_name: Leonard, Norma last_name: Leonard - first_name: Faten full_name: Tinsa, Faten last_name: Tinsa - first_name: Stéphanie full_name: Moortgat, Stéphanie last_name: Moortgat - first_name: Hakan full_name: Ulucan, Hakan last_name: Ulucan - first_name: Erkan full_name: Koparir, Erkan last_name: Koparir - first_name: Ender full_name: Karaca, Ender last_name: Karaca - first_name: Nicholas full_name: Katsanis, Nicholas last_name: Katsanis - first_name: Valeria full_name: Marton, Valeria last_name: Marton - first_name: Joris R full_name: Vermeesch, Joris R last_name: Vermeesch - first_name: Erica E full_name: Davis, Erica E last_name: Davis - first_name: Nicholas J full_name: Cowan, Nicholas J last_name: Cowan - first_name: David full_name: Keays, David last_name: Keays - first_name: Hilde full_name: Van Esch, Hilde last_name: Van Esch citation: ama: Isrie M, Breuss M, Tian G, et al. Mutations in either TUBB or MAPRE2 cause circumferential skin creases Kunze type. The American Journal of Human Genetics. 2015;97(6):790-800. doi:10.1016/j.ajhg.2015.10.014 apa: Isrie, M., Breuss, M., Tian, G., Hansen, A. H., Cristofoli, F., Morandell, J., … Van Esch, H. (2015). Mutations in either TUBB or MAPRE2 cause circumferential skin creases Kunze type. The American Journal of Human Genetics. Cell Press. https://doi.org/10.1016/j.ajhg.2015.10.014 chicago: Isrie, Mala, Martin Breuss, Guoling Tian, Andi H Hansen, Francesca Cristofoli, Jasmin Morandell, Zachari A Kupchinsky, et al. “Mutations in Either TUBB or MAPRE2 Cause Circumferential Skin Creases Kunze Type.” The American Journal of Human Genetics. Cell Press, 2015. https://doi.org/10.1016/j.ajhg.2015.10.014. ieee: M. Isrie et al., “Mutations in either TUBB or MAPRE2 cause circumferential skin creases Kunze type,” The American Journal of Human Genetics, vol. 97, no. 6. Cell Press, pp. 790–800, 2015. ista: Isrie M, Breuss M, Tian G, Hansen AH, Cristofoli F, Morandell J, Kupchinsky ZA, Sifrim A, Rodriguez Rodriguez C, Dapena EP, Doonanco K, Leonard N, Tinsa F, Moortgat S, Ulucan H, Koparir E, Karaca E, Katsanis N, Marton V, Vermeesch JR, Davis EE, Cowan NJ, Keays D, Van Esch H. 2015. Mutations in either TUBB or MAPRE2 cause circumferential skin creases Kunze type. The American Journal of Human Genetics. 97(6), 790–800. mla: Isrie, Mala, et al. “Mutations in Either TUBB or MAPRE2 Cause Circumferential Skin Creases Kunze Type.” The American Journal of Human Genetics, vol. 97, no. 6, Cell Press, 2015, pp. 790–800, doi:10.1016/j.ajhg.2015.10.014. short: M. Isrie, M. Breuss, G. Tian, A.H. Hansen, F. Cristofoli, J. Morandell, Z.A. Kupchinsky, A. Sifrim, C. Rodriguez Rodriguez, E.P. Dapena, K. Doonanco, N. Leonard, F. Tinsa, S. Moortgat, H. Ulucan, E. Koparir, E. Karaca, N. Katsanis, V. Marton, J.R. Vermeesch, E.E. Davis, N.J. Cowan, D. Keays, H. Van Esch, The American Journal of Human Genetics 97 (2015) 790–800. date_created: 2018-12-11T11:50:11Z date_published: 2015-12-03T00:00:00Z date_updated: 2025-09-23T09:38:06Z day: '03' doi: 10.1016/j.ajhg.2015.10.014 extern: '1' external_id: isi: - '000368437900002' intvolume: ' 97' isi: 1 issue: '6' language: - iso: eng month: '12' oa_version: None page: 790 - 800 publication: The American Journal of Human Genetics publication_status: published publisher: Cell Press publist_id: '6264' quality_controlled: '1' status: public title: Mutations in either TUBB or MAPRE2 cause circumferential skin creases Kunze type type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 97 year: '2015' ... --- _id: '11073' abstract: - lang: eng text: Human cancer cells bear complex chromosome rearrangements that can be potential drivers of cancer development. However, the molecular mechanisms underlying these rearrangements have been unclear. Zhang et al. use a new technique combining live-cell imaging and single-cell sequencing to demonstrate that chromosomes mis-segregated to micronuclei frequently undergo chromothripsis-like rearrangements in the subsequent cell cycle. article_processing_charge: No article_type: original author: - first_name: Emily M. full_name: Hatch, Emily M. last_name: Hatch - first_name: Martin W full_name: HETZER, Martin W id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed last_name: HETZER orcid: 0000-0002-2111-992X citation: ama: Hatch EM, Hetzer M. Linking micronuclei to chromosome fragmentation. Cell. 2015;161(7):1502-1504. doi:10.1016/j.cell.2015.06.005 apa: Hatch, E. M., & Hetzer, M. (2015). Linking micronuclei to chromosome fragmentation. Cell. Elsevier. https://doi.org/10.1016/j.cell.2015.06.005 chicago: Hatch, Emily M., and Martin Hetzer. “Linking Micronuclei to Chromosome Fragmentation.” Cell. Elsevier, 2015. https://doi.org/10.1016/j.cell.2015.06.005. ieee: E. M. Hatch and M. Hetzer, “Linking micronuclei to chromosome fragmentation,” Cell, vol. 161, no. 7. Elsevier, pp. 1502–1504, 2015. ista: Hatch EM, Hetzer M. 2015. Linking micronuclei to chromosome fragmentation. Cell. 161(7), 1502–1504. mla: Hatch, Emily M., and Martin Hetzer. “Linking Micronuclei to Chromosome Fragmentation.” Cell, vol. 161, no. 7, Elsevier, 2015, pp. 1502–04, doi:10.1016/j.cell.2015.06.005. short: E.M. Hatch, M. Hetzer, Cell 161 (2015) 1502–1504. date_created: 2022-04-07T07:48:49Z date_published: 2015-06-18T00:00:00Z date_updated: 2024-10-14T11:22:03Z day: '18' doi: 10.1016/j.cell.2015.06.005 extern: '1' external_id: pmid: - '26091034' intvolume: ' 161' issue: '7' keyword: - General Biochemistry - Genetics and Molecular Biology language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1016/j.cell.2015.06.005 month: '06' oa: 1 oa_version: Published Version page: 1502-1504 pmid: 1 publication: Cell publication_identifier: issn: - 0092-8674 publication_status: published publisher: Elsevier quality_controlled: '1' scopus_import: '1' status: public title: Linking micronuclei to chromosome fragmentation type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 161 year: '2015' ... --- _id: '11074' article_processing_charge: No article_type: original author: - first_name: Emily M. full_name: Hatch, Emily M. last_name: Hatch - first_name: Martin W full_name: HETZER, Martin W id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed last_name: HETZER orcid: 0000-0002-2111-992X citation: ama: Hatch EM, Hetzer M. Chromothripsis. Current Biology. 2015;25(10):PR397-R399. doi:10.1016/j.cub.2015.02.033 apa: Hatch, E. M., & Hetzer, M. (2015). Chromothripsis. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2015.02.033 chicago: Hatch, Emily M., and Martin Hetzer. “Chromothripsis.” Current Biology. Elsevier, 2015. https://doi.org/10.1016/j.cub.2015.02.033. ieee: E. M. Hatch and M. Hetzer, “Chromothripsis,” Current Biology, vol. 25, no. 10. Elsevier, pp. PR397-R399, 2015. ista: Hatch EM, Hetzer M. 2015. Chromothripsis. Current Biology. 25(10), PR397-R399. mla: Hatch, Emily M., and Martin Hetzer. “Chromothripsis.” Current Biology, vol. 25, no. 10, Elsevier, 2015, pp. PR397-R399, doi:10.1016/j.cub.2015.02.033. short: E.M. Hatch, M. Hetzer, Current Biology 25 (2015) PR397-R399. date_created: 2022-04-07T07:49:00Z date_published: 2015-05-18T00:00:00Z date_updated: 2024-10-14T11:22:15Z day: '18' doi: 10.1016/j.cub.2015.02.033 extern: '1' external_id: pmid: - '25989073' intvolume: ' 25' issue: '10' keyword: - General Agricultural and Biological Sciences - General Biochemistry - Genetics and Molecular Biology language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1016/j.cub.2015.02.033 month: '05' oa: 1 oa_version: Published Version page: PR397-R399 pmid: 1 publication: Current Biology publication_identifier: issn: - 0960-9822 publication_status: published publisher: Elsevier quality_controlled: '1' scopus_import: '1' status: public title: Chromothripsis type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 25 year: '2015' ... --- _id: '11075' abstract: - lang: eng text: Previously, we identified the nucleoporin gp210/Nup210 as a critical regulator of muscle and neuronal differentiation, but how this nucleoporin exerts its function and whether it modulates nuclear pore complex (NPC) activity remain unknown. Here, we show that gp210/Nup210 mediates muscle cell differentiation in vitro via its conserved N-terminal domain that extends into the perinuclear space. Removal of the C-terminal domain, which partially mislocalizes gp210/Nup210 away from NPCs, efficiently rescues the differentiation defect caused by the knockdown of endogenous gp210/Nup210. Unexpectedly, a gp210/Nup210 mutant lacking the NPC-targeting transmembrane and C-terminal domains is sufficient for C2C12 myoblast differentiation. We demonstrate that the endoplasmic reticulum (ER) stress-specific caspase cascade is exacerbated during Nup210 depletion and that blocking ER stress-mediated apoptosis rescues differentiation of Nup210-deficient cells. Our results suggest that the role of gp210/Nup210 in cell differentiation is mediated by its large luminal domain, which can act independently of NPC association and appears to play a pivotal role in the maintenance of nuclear envelope/ER homeostasis. article_processing_charge: No article_type: original author: - first_name: J. Sebastian full_name: Gomez-Cavazos, J. Sebastian last_name: Gomez-Cavazos - first_name: Martin W full_name: HETZER, Martin W id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed last_name: HETZER orcid: 0000-0002-2111-992X citation: ama: Gomez-Cavazos JS, Hetzer M. The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. Journal of Cell Biology. 2015;208(6):671-681. doi:10.1083/jcb.201410047 apa: Gomez-Cavazos, J. S., & Hetzer, M. (2015). The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. Journal of Cell Biology. Rockefeller University Press. https://doi.org/10.1083/jcb.201410047 chicago: Gomez-Cavazos, J. Sebastian, and Martin Hetzer. “The Nucleoporin Gp210/Nup210 Controls Muscle Differentiation by Regulating Nuclear Envelope/ER Homeostasis.” Journal of Cell Biology. Rockefeller University Press, 2015. https://doi.org/10.1083/jcb.201410047. ieee: J. S. Gomez-Cavazos and M. Hetzer, “The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis,” Journal of Cell Biology, vol. 208, no. 6. Rockefeller University Press, pp. 671–681, 2015. ista: Gomez-Cavazos JS, Hetzer M. 2015. The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. Journal of Cell Biology. 208(6), 671–681. mla: Gomez-Cavazos, J. Sebastian, and Martin Hetzer. “The Nucleoporin Gp210/Nup210 Controls Muscle Differentiation by Regulating Nuclear Envelope/ER Homeostasis.” Journal of Cell Biology, vol. 208, no. 6, Rockefeller University Press, 2015, pp. 671–81, doi:10.1083/jcb.201410047. short: J.S. Gomez-Cavazos, M. Hetzer, Journal of Cell Biology 208 (2015) 671–681. date_created: 2022-04-07T07:49:10Z date_published: 2015-03-16T00:00:00Z date_updated: 2024-10-14T11:22:26Z day: '16' doi: 10.1083/jcb.201410047 extern: '1' external_id: pmid: - '25778917' intvolume: ' 208' issue: '6' keyword: - Cell Biology language: - iso: eng month: '03' oa_version: Published Version page: 671-681 pmid: 1 publication: Journal of Cell Biology publication_identifier: eissn: - 1540-8140 issn: - 0021-9525 publication_status: published publisher: Rockefeller University Press quality_controlled: '1' scopus_import: '1' status: public title: The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 208 year: '2015' ... --- _id: '11076' abstract: - lang: eng text: Nuclear pore complexes (NPCs) are composed of several copies of ∼30 different proteins called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the nucleocytoplasmic trafficking of macromolecules. Beyond this vital role, NPC components influence genome functions in a transport-independent manner. Nups play an evolutionarily conserved role in gene expression regulation that, in metazoans, extends into the nuclear interior. Additionally, in proliferative cells, Nups play a crucial role in genome integrity maintenance and mitotic progression. Here we discuss genome-related functions of Nups and their impact on essential DNA metabolism processes such as transcription, chromosome duplication, and segregation. article_processing_charge: No article_type: original author: - first_name: Arkaitz full_name: Ibarra, Arkaitz last_name: Ibarra - first_name: Martin W full_name: HETZER, Martin W id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed last_name: HETZER orcid: 0000-0002-2111-992X citation: ama: Ibarra A, Hetzer M. Nuclear pore proteins and the control of genome functions. Genes & Development. 2015;29(4):337-349. doi:10.1101/gad.256495.114 apa: Ibarra, A., & Hetzer, M. (2015). Nuclear pore proteins and the control of genome functions. Genes & Development. Cold Spring Harbor Laboratory. https://doi.org/10.1101/gad.256495.114 chicago: Ibarra, Arkaitz, and Martin Hetzer. “Nuclear Pore Proteins and the Control of Genome Functions.” Genes & Development. Cold Spring Harbor Laboratory, 2015. https://doi.org/10.1101/gad.256495.114. ieee: A. Ibarra and M. Hetzer, “Nuclear pore proteins and the control of genome functions,” Genes & Development, vol. 29, no. 4. Cold Spring Harbor Laboratory, pp. 337–349, 2015. ista: Ibarra A, Hetzer M. 2015. Nuclear pore proteins and the control of genome functions. Genes & Development. 29(4), 337–349. mla: Ibarra, Arkaitz, and Martin Hetzer. “Nuclear Pore Proteins and the Control of Genome Functions.” Genes & Development, vol. 29, no. 4, Cold Spring Harbor Laboratory, 2015, pp. 337–49, doi:10.1101/gad.256495.114. short: A. Ibarra, M. Hetzer, Genes & Development 29 (2015) 337–349. date_created: 2022-04-07T07:49:21Z date_published: 2015-02-01T00:00:00Z date_updated: 2024-10-14T11:22:36Z day: '01' doi: 10.1101/gad.256495.114 extern: '1' external_id: pmid: - '25691464' intvolume: ' 29' issue: '4' keyword: - Developmental Biology - Genetics language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1101/gad.256495.114 month: '02' oa: 1 oa_version: Published Version page: 337-349 pmid: 1 publication: Genes & Development publication_identifier: eissn: - 1549-5477 issn: - 0890-9369 publication_status: published publisher: Cold Spring Harbor Laboratory quality_controlled: '1' scopus_import: '1' status: public title: Nuclear pore proteins and the control of genome functions type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 29 year: '2015' ... --- _id: '11077' abstract: - lang: eng text: Nucleoporins (Nups) are a family of proteins best known as the constituent building blocks of nuclear pore complexes (NPCs), membrane-embedded channels that mediate nuclear transport across the nuclear envelope. Recent evidence suggests that several Nups have additional roles in controlling the activation and silencing of developmental genes; however, the mechanistic details of these functions remain poorly understood. Here, we show that depletion of Nup153 in mouse embryonic stem cells (mESCs) causes the derepression of developmental genes and induction of early differentiation. This loss of stem cell identity is not associated with defects in the nuclear import of key pluripotency factors. Rather, Nup153 binds around the transcriptional start site (TSS) of developmental genes and mediates the recruitment of the polycomb-repressive complex 1 (PRC1) to a subset of its target loci. Our results demonstrate a chromatin-associated role of Nup153 in maintaining stem cell pluripotency by functioning in mammalian epigenetic gene silencing. article_processing_charge: No article_type: original author: - first_name: Filipe V. full_name: Jacinto, Filipe V. last_name: Jacinto - first_name: Chris full_name: Benner, Chris last_name: Benner - first_name: Martin W full_name: HETZER, Martin W id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed last_name: HETZER orcid: 0000-0002-2111-992X citation: ama: Jacinto FV, Benner C, Hetzer M. The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. Genes & Development. 2015;29(12):1224-1238. doi:10.1101/gad.260919.115 apa: Jacinto, F. V., Benner, C., & Hetzer, M. (2015). The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. Genes & Development. Cold Spring Harbor Laboratory. https://doi.org/10.1101/gad.260919.115 chicago: Jacinto, Filipe V., Chris Benner, and Martin Hetzer. “The Nucleoporin Nup153 Regulates Embryonic Stem Cell Pluripotency through Gene Silencing.” Genes & Development. Cold Spring Harbor Laboratory, 2015. https://doi.org/10.1101/gad.260919.115. ieee: F. V. Jacinto, C. Benner, and M. Hetzer, “The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing,” Genes & Development, vol. 29, no. 12. Cold Spring Harbor Laboratory, pp. 1224–1238, 2015. ista: Jacinto FV, Benner C, Hetzer M. 2015. The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. Genes & Development. 29(12), 1224–1238. mla: Jacinto, Filipe V., et al. “The Nucleoporin Nup153 Regulates Embryonic Stem Cell Pluripotency through Gene Silencing.” Genes & Development, vol. 29, no. 12, Cold Spring Harbor Laboratory, 2015, pp. 1224–38, doi:10.1101/gad.260919.115. short: F.V. Jacinto, C. Benner, M. Hetzer, Genes & Development 29 (2015) 1224–1238. date_created: 2022-04-07T07:49:31Z date_published: 2015-06-16T00:00:00Z date_updated: 2024-10-14T11:22:47Z day: '16' doi: 10.1101/gad.260919.115 extern: '1' external_id: pmid: - '26080816' intvolume: ' 29' issue: '12' keyword: - Developmental Biology - Genetics language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1101/gad.260919.115 month: '06' oa: 1 oa_version: Published Version page: 1224-1238 pmid: 1 publication: Genes & Development publication_identifier: eissn: - 1549-5477 issn: - 0890-9369 publication_status: published publisher: Cold Spring Harbor Laboratory quality_controlled: '1' scopus_import: '1' status: public title: The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 29 year: '2015' ... --- _id: '11078' abstract: - lang: eng text: Aging is associated with the decline of protein, cell, and organ function. Here, we use an integrated approach to characterize gene expression, bulk translation, and cell biology in the brains and livers of young and old rats. We identify 468 differences in protein abundance between young and old animals. The majority are a consequence of altered translation output, that is, the combined effect of changes in transcript abundance and translation efficiency. In addition, we identify 130 proteins whose overall abundance remains unchanged but whose sub-cellular localization, phosphorylation state, or splice-form varies. While some protein-level differences appear to be a generic property of the rats’ chronological age, the majority are specific to one organ. These may be a consequence of the organ’s physiology or the chronological age of the cells within the tissue. Taken together, our study provides an initial view of the proteome at the molecular, sub-cellular, and organ level in young and old rats. article_processing_charge: No article_type: original author: - first_name: Alessandro full_name: Ori, Alessandro last_name: Ori - first_name: Brandon H. full_name: Toyama, Brandon H. last_name: Toyama - first_name: Michael S. full_name: Harris, Michael S. last_name: Harris - first_name: Thomas full_name: Bock, Thomas last_name: Bock - first_name: Murat full_name: Iskar, Murat last_name: Iskar - first_name: Peer full_name: Bork, Peer last_name: Bork - first_name: Nicholas T. full_name: Ingolia, Nicholas T. last_name: Ingolia - first_name: Martin W full_name: HETZER, Martin W id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed last_name: HETZER orcid: 0000-0002-2111-992X - first_name: Martin full_name: Beck, Martin last_name: Beck citation: ama: Ori A, Toyama BH, Harris MS, et al. Integrated transcriptome and proteome analyses reveal organ-specific proteome deterioration in old rats. Cell Systems. 2015;1(3):P224-237. doi:10.1016/j.cels.2015.08.012 apa: Ori, A., Toyama, B. H., Harris, M. S., Bock, T., Iskar, M., Bork, P., … Beck, M. (2015). Integrated transcriptome and proteome analyses reveal organ-specific proteome deterioration in old rats. Cell Systems. Elsevier. https://doi.org/10.1016/j.cels.2015.08.012 chicago: Ori, Alessandro, Brandon H. Toyama, Michael S. Harris, Thomas Bock, Murat Iskar, Peer Bork, Nicholas T. Ingolia, Martin Hetzer, and Martin Beck. “Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats.” Cell Systems. Elsevier, 2015. https://doi.org/10.1016/j.cels.2015.08.012. ieee: A. Ori et al., “Integrated transcriptome and proteome analyses reveal organ-specific proteome deterioration in old rats,” Cell Systems, vol. 1, no. 3. Elsevier, pp. P224-237, 2015. ista: Ori A, Toyama BH, Harris MS, Bock T, Iskar M, Bork P, Ingolia NT, Hetzer M, Beck M. 2015. Integrated transcriptome and proteome analyses reveal organ-specific proteome deterioration in old rats. Cell Systems. 1(3), P224-237. mla: Ori, Alessandro, et al. “Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats.” Cell Systems, vol. 1, no. 3, Elsevier, 2015, pp. P224-237, doi:10.1016/j.cels.2015.08.012. short: A. Ori, B.H. Toyama, M.S. Harris, T. Bock, M. Iskar, P. Bork, N.T. Ingolia, M. Hetzer, M. Beck, Cell Systems 1 (2015) P224-237. date_created: 2022-04-07T07:49:39Z date_published: 2015-09-23T00:00:00Z date_updated: 2024-10-14T11:23:01Z day: '23' doi: 10.1016/j.cels.2015.08.012 extern: '1' external_id: pmid: - '27135913' intvolume: ' 1' issue: '3' keyword: - Cell Biology - Histology - Pathology and Forensic Medicine language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1016/j.cels.2015.08.012 month: '09' oa: 1 oa_version: Published Version page: P224-237 pmid: 1 publication: Cell Systems publication_identifier: issn: - 2405-4712 publication_status: published publisher: Elsevier quality_controlled: '1' scopus_import: '1' status: public title: Integrated transcriptome and proteome analyses reveal organ-specific proteome deterioration in old rats type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 1 year: '2015' ... --- _id: '11079' abstract: - lang: eng text: Aging is a major risk factor for many human diseases, and in vitro generation of human neurons is an attractive approach for modeling aging-related brain disorders. However, modeling aging in differentiated human neurons has proved challenging. We generated neurons from human donors across a broad range of ages, either by iPSC-based reprogramming and differentiation or by direct conversion into induced neurons (iNs). While iPSCs and derived neurons did not retain aging-associated gene signatures, iNs displayed age-specific transcriptional profiles and revealed age-associated decreases in the nuclear transport receptor RanBP17. We detected an age-dependent loss of nucleocytoplasmic compartmentalization (NCC) in donor fibroblasts and corresponding iNs and found that reduced RanBP17 impaired NCC in young cells, while iPSC rejuvenation restored NCC in aged cells. These results show that iNs retain important aging-related signatures, thus allowing modeling of the aging process in vitro, and they identify impaired NCC as an important factor in human aging. article_processing_charge: No article_type: original author: - first_name: Jerome full_name: Mertens, Jerome last_name: Mertens - first_name: Apuã C.M. full_name: Paquola, Apuã C.M. last_name: Paquola - first_name: Manching full_name: Ku, Manching last_name: Ku - first_name: Emily full_name: Hatch, Emily last_name: Hatch - first_name: Lena full_name: Böhnke, Lena last_name: Böhnke - first_name: Shauheen full_name: Ladjevardi, Shauheen last_name: Ladjevardi - first_name: Sean full_name: McGrath, Sean last_name: McGrath - first_name: Benjamin full_name: Campbell, Benjamin last_name: Campbell - first_name: Hyungjun full_name: Lee, Hyungjun last_name: Lee - first_name: Joseph R. full_name: Herdy, Joseph R. last_name: Herdy - first_name: J. Tiago full_name: Gonçalves, J. Tiago last_name: Gonçalves - first_name: Tomohisa full_name: Toda, Tomohisa last_name: Toda - first_name: Yongsung full_name: Kim, Yongsung last_name: Kim - first_name: Jürgen full_name: Winkler, Jürgen last_name: Winkler - first_name: Jun full_name: Yao, Jun last_name: Yao - first_name: Martin W full_name: HETZER, Martin W id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed last_name: HETZER orcid: 0000-0002-2111-992X - first_name: Fred H. full_name: Gage, Fred H. last_name: Gage citation: ama: Mertens J, Paquola ACM, Ku M, et al. Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects. Cell Stem Cell. 2015;17(6):705-718. doi:10.1016/j.stem.2015.09.001 apa: Mertens, J., Paquola, A. C. M., Ku, M., Hatch, E., Böhnke, L., Ladjevardi, S., … Gage, F. H. (2015). Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects. Cell Stem Cell. Elsevier. https://doi.org/10.1016/j.stem.2015.09.001 chicago: Mertens, Jerome, Apuã C.M. Paquola, Manching Ku, Emily Hatch, Lena Böhnke, Shauheen Ladjevardi, Sean McGrath, et al. “Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.” Cell Stem Cell. Elsevier, 2015. https://doi.org/10.1016/j.stem.2015.09.001. ieee: J. Mertens et al., “Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects,” Cell Stem Cell, vol. 17, no. 6. Elsevier, pp. 705–718, 2015. ista: Mertens J, Paquola ACM, Ku M, Hatch E, Böhnke L, Ladjevardi S, McGrath S, Campbell B, Lee H, Herdy JR, Gonçalves JT, Toda T, Kim Y, Winkler J, Yao J, Hetzer M, Gage FH. 2015. Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects. Cell Stem Cell. 17(6), 705–718. mla: Mertens, Jerome, et al. “Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.” Cell Stem Cell, vol. 17, no. 6, Elsevier, 2015, pp. 705–18, doi:10.1016/j.stem.2015.09.001. short: J. Mertens, A.C.M. Paquola, M. Ku, E. Hatch, L. Böhnke, S. Ladjevardi, S. McGrath, B. Campbell, H. Lee, J.R. Herdy, J.T. Gonçalves, T. Toda, Y. Kim, J. Winkler, J. Yao, M. Hetzer, F.H. Gage, Cell Stem Cell 17 (2015) 705–718. date_created: 2022-04-07T07:49:51Z date_published: 2015-12-03T00:00:00Z date_updated: 2022-07-18T08:44:21Z day: '03' doi: 10.1016/j.stem.2015.09.001 extern: '1' external_id: pmid: - '26456686' intvolume: ' 17' issue: '6' keyword: - Cell Biology - Genetics - Molecular Medicine language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1016/j.stem.2015.09.001 month: '12' oa: 1 oa_version: Published Version page: 705-718 pmid: 1 publication: Cell Stem Cell publication_identifier: issn: - 1934-5909 publication_status: published publisher: Elsevier quality_controlled: '1' scopus_import: '1' status: public title: Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects type: journal_article user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd volume: 17 year: '2015' ... --- _id: '11519' abstract: - lang: eng text: 'Faint Lyα emitters become increasingly rarer toward the reionization epoch (z ∼ 6–7). However, observations from a very large (∼5 deg2) Lyα narrow-band survey at z = 6.6 show that this is not the case for the most luminous emitters, capable of ionizing their own local bubbles. Here we present follow-up observations of the two most luminous Lyα candidates in the COSMOS field: “MASOSA” and “CR7.” We used X-SHOOTER, SINFONI, and FORS2 on the Very Large Telescope, and DEIMOS on Keck, to confirm both candidates beyond any doubt. We find redshifts of z = 6.541 and z = 6.604 for “MASOSA” and “CR7,” respectively. MASOSA has a strong detection in Lyα with a line width of 386 ± 30 km s−1 (FWHM) and with very high EW0 (>200 Å), but undetected in the continuum, implying very low stellar mass and a likely young, metal-poor stellar population. “CR7,” with an observed Lyα luminosity of 1043.92±0.05 erg s−1 is the most luminous Lyα emitter ever found at z > 6 and is spatially extended (∼16 kpc). “CR7” reveals a narrow Lyα line with 266 ± 15 km s−1 FWHM, being detected in the near-infrared (NIR) (rest-frame UV; β = −2.3 ± 0.1) and in IRAC/Spitzer. We detect a narrow He II 1640 Å emission line (6σ, FWHM = 130 ± 30 km s−1 ) in CR7 which can explain the clear excess seen in the J-band photometry (EW0 ∼ 80 Å). We find no other emission lines from the UV to the NIR in our X-SHOOTER spectra (He II/O III] 1663 Å > 3 and He II/C III] 1908 Å > 2.5). We conclude that CR7 is best explained by a combination of a PopIII-like population, which dominates the rest-frame UV and the nebular emission, and a more normal stellar population, which presumably dominates the mass. Hubble Space Telescope/WFC3 observations show that the light is indeed spatially separated between a very blue component, coincident with Lyα and He II emission, and two red components (∼5 kpc away), which dominate the mass. Our findings are consistent with theoretical predictions of a PopIII wave, with PopIII star formation migrating away from the original sites of star formation.' acknowledgement: We thank the anonymous reviewer for useful and constructive comments and suggestions which greatly improved the quality and clarity of our work. D.S. acknowledges financial support from the Netherlands Organisation for Scientific research (NWO) through a Veni fellowship, from FCT through a FCT Investigator Starting Grant and Start-up Grant (IF/01154/2012/CP0189/CT0010), from FCT grant UID/FIS/04434/2013, and from LSF and LKBF. J.M. acknowledges the award of a Huygens PhD fellowship. H.R. acknowledges support from the ERC Advanced Investigator program NewClusters 321271. The authors thank Mark Dijkstra, Bhaskar Agarwal, Jarrett Johnson, Andrea Ferrara, Jarle Brinchmann, Rebecca Bowler, George Becker, Emma Curtis-Lake, Milos Milosavljevic, Raffaella Schneider, Paul Shapiro, and Erik Zackrisson for interesting, stimulating and helpful discussions. The authors are extremely grateful to ESO for the award of ESO DDT time (294.A-5018 and 294.A-5039) which allowed the spectroscopic confirmation of both sources and the detailed investigation of their nature. Observations are also based on data from W.M. Keck Observatory. The W.M. Keck Observatory is operated as a scientific partnership of Caltech, the University of California and the National Aeronautics and Space Administration. Based on observations obtained with MegaPrime/Megacam, a joint project of CFHT and CEA/IRFU, at the Canada–France–Hawaii Telescope (CFHT) which is operated by the National Research Council (NRC) of Canada, the Institut National des Science de lUnivers of the Centre National de la Recherche Scientifique (CNRS) of France, and the University of Hawaii. This work is based in part on data products produced at Terapix available at the Canadian Astronomy Data Centre as part of the Canada–France–Hawaii Telescope Legacy Survey, a collaborative project of NRC and CNRS. Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under ESO programme IDs 294.A-5018, 294.A-5039, and 179.A-2005, and on data products produced by TERAPIX and the Cambridge Astronomy Survey Unit on behalf of the UltraVISTA consortium. The authors acknowledge the award of service time (SW2014b20) on the William Herschel Telescope (WHT). WHT and its service programme are operated on the island of La Palma by the Isaac Newton Group in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias. article_processing_charge: No article_type: original arxiv: 1 author: - first_name: David full_name: Sobral, David last_name: Sobral - first_name: Jorryt J full_name: Matthee, Jorryt J id: 7439a258-f3c0-11ec-9501-9df22fe06720 last_name: Matthee orcid: 0000-0003-2871-127X - first_name: Behnam full_name: Darvish, Behnam last_name: Darvish - first_name: Daniel full_name: Schaerer, Daniel last_name: Schaerer - first_name: Bahram full_name: Mobasher, Bahram last_name: Mobasher - first_name: Huub full_name: Röttgering, Huub last_name: Röttgering - first_name: Sérgio full_name: Santos, Sérgio last_name: Santos - first_name: Shoubaneh full_name: Hemmati, Shoubaneh last_name: Hemmati citation: ama: 'Sobral D, Matthee JJ, Darvish B, et al. Evidence for PopIII-like stellar populations in the most luminous Lyα emitters at the epoch of reionisation: Spectroscopic confirmation. The Astrophysical Journal. 2015;808(2):139. doi:10.1088/0004-637X/808/2/139' apa: 'Sobral, D., Matthee, J. J., Darvish, B., Schaerer, D., Mobasher, B., Röttgering, H., … Hemmati, S. (2015). Evidence for PopIII-like stellar populations in the most luminous Lyα emitters at the epoch of reionisation: Spectroscopic confirmation. The Astrophysical Journal. IOP Publishing. https://doi.org/10.1088/0004-637X/808/2/139' chicago: 'Sobral, David, Jorryt J Matthee, Behnam Darvish, Daniel Schaerer, Bahram Mobasher, Huub Röttgering, Sérgio Santos, and Shoubaneh Hemmati. “Evidence for PopIII-like Stellar Populations in the Most Luminous Lyα Emitters at the Epoch of Reionisation: Spectroscopic Confirmation.” The Astrophysical Journal. IOP Publishing, 2015. https://doi.org/10.1088/0004-637X/808/2/139.' ieee: 'D. Sobral et al., “Evidence for PopIII-like stellar populations in the most luminous Lyα emitters at the epoch of reionisation: Spectroscopic confirmation,” The Astrophysical Journal, vol. 808, no. 2. IOP Publishing, p. 139, 2015.' ista: 'Sobral D, Matthee JJ, Darvish B, Schaerer D, Mobasher B, Röttgering H, Santos S, Hemmati S. 2015. Evidence for PopIII-like stellar populations in the most luminous Lyα emitters at the epoch of reionisation: Spectroscopic confirmation. The Astrophysical Journal. 808(2), 139.' mla: 'Sobral, David, et al. “Evidence for PopIII-like Stellar Populations in the Most Luminous Lyα Emitters at the Epoch of Reionisation: Spectroscopic Confirmation.” The Astrophysical Journal, vol. 808, no. 2, IOP Publishing, 2015, p. 139, doi:10.1088/0004-637X/808/2/139.' short: D. Sobral, J.J. Matthee, B. Darvish, D. Schaerer, B. Mobasher, H. Röttgering, S. Santos, S. Hemmati, The Astrophysical Journal 808 (2015) 139. date_created: 2022-07-07T09:00:58Z date_published: 2015-07-28T00:00:00Z date_updated: 2022-08-18T10:30:13Z day: '28' doi: 10.1088/0004-637X/808/2/139 extern: '1' external_id: arxiv: - '1504.01734' intvolume: ' 808' issue: '2' keyword: - Space and Planetary Science - Astronomy and Astrophysics - dark ages - reionization - 'first stars – early universe – galaxies: evolution' language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/1504.01734 month: '07' oa: 1 oa_version: Preprint page: '139' publication: The Astrophysical Journal publication_identifier: eissn: - 1538-4357 issn: - 0004-637X publication_status: published publisher: IOP Publishing quality_controlled: '1' scopus_import: '1' status: public title: 'Evidence for PopIII-like stellar populations in the most luminous Lyα emitters at the epoch of reionisation: Spectroscopic confirmation' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 808 year: '2015' ... --- _id: '11579' abstract: - lang: eng text: CR7 is the brightest z = 6.6 Ly α emitter (LAE) known to date, and spectroscopic follow-up by Sobral et al. suggests that CR7 might host Population (Pop) III stars. We examine this interpretation using cosmological hydrodynamical simulations. Several simulated galaxies show the same ‘Pop III wave’ pattern observed in CR7. However, to reproduce the extreme CR7 Ly α/He II1640 line luminosities (⁠Lα/HeII⁠) a top-heavy initial mass function and a massive ( ≳ 107 M⊙) Pop III burst with age ≲ 2 Myr are required. Assuming that the observed properties of Ly α and He II emission are typical for Pop III, we predict that in the COSMOS/UDS/SA22 fields, 14 out of the 30 LAEs at z = 6.6 with Lα > 1043.3 erg s−1 should also host Pop III stars producing an observable LHeII≳1042.7ergs−1⁠. As an alternate explanation, we explore the possibility that CR7 is instead powered by accretion on to a direct collapse black hole. Our model predicts Lα, LHeII⁠, and X-ray luminosities that are in agreement with the observations. In any case, the observed properties of CR7 indicate that this galaxy is most likely powered by sources formed from pristine gas. We propose that further X-ray observations can distinguish between the two above scenarios. acknowledgement: SS acknowledges support from the Netherlands Organization for Scientific research (NWO), VENI grant 639.041.233. RS acknowledges support from the European Research Council under the European Union (FP/2007-2013)/ERC grant agreement no. 306476. DS acknowledges (i) financial support from the NWO through a Veni fellowship and (ii) funding from FCT through a FCT Investigator Starting Grant and Start-up Grant (IF/01154/2012/CP0189/CT0010) and from FCT grant PEstOE/FIS/UI2751/2014. article_processing_charge: No article_type: original arxiv: 1 author: - first_name: A. full_name: Pallottini, A. last_name: Pallottini - first_name: A. full_name: Ferrara, A. last_name: Ferrara - first_name: F. full_name: Pacucci, F. last_name: Pacucci - first_name: S. full_name: Gallerani, S. last_name: Gallerani - first_name: S. full_name: Salvadori, S. last_name: Salvadori - first_name: R. full_name: Schneider, R. last_name: Schneider - first_name: D. full_name: Schaerer, D. last_name: Schaerer - first_name: D. full_name: Sobral, D. last_name: Sobral - first_name: Jorryt J full_name: Matthee, Jorryt J id: 7439a258-f3c0-11ec-9501-9df22fe06720 last_name: Matthee orcid: 0000-0003-2871-127X citation: ama: 'Pallottini A, Ferrara A, Pacucci F, et al. The brightest Lyα emitter: Pop III or black hole? Monthly Notices of the Royal Astronomical Society. 2015;453(3):2465-2470. doi:10.1093/mnras/stv1795' apa: 'Pallottini, A., Ferrara, A., Pacucci, F., Gallerani, S., Salvadori, S., Schneider, R., … Matthee, J. J. (2015). The brightest Lyα emitter: Pop III or black hole? Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/stv1795' chicago: 'Pallottini, A., A. Ferrara, F. Pacucci, S. Gallerani, S. Salvadori, R. Schneider, D. Schaerer, D. Sobral, and Jorryt J Matthee. “The Brightest Lyα Emitter: Pop III or Black Hole?” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2015. https://doi.org/10.1093/mnras/stv1795.' ieee: 'A. Pallottini et al., “The brightest Lyα emitter: Pop III or black hole?,” Monthly Notices of the Royal Astronomical Society, vol. 453, no. 3. Oxford University Press, pp. 2465–2470, 2015.' ista: 'Pallottini A, Ferrara A, Pacucci F, Gallerani S, Salvadori S, Schneider R, Schaerer D, Sobral D, Matthee JJ. 2015. The brightest Lyα emitter: Pop III or black hole? Monthly Notices of the Royal Astronomical Society. 453(3), 2465–2470.' mla: 'Pallottini, A., et al. “The Brightest Lyα Emitter: Pop III or Black Hole?” Monthly Notices of the Royal Astronomical Society, vol. 453, no. 3, Oxford University Press, 2015, pp. 2465–70, doi:10.1093/mnras/stv1795.' short: A. Pallottini, A. Ferrara, F. Pacucci, S. Gallerani, S. Salvadori, R. Schneider, D. Schaerer, D. Sobral, J.J. Matthee, Monthly Notices of the Royal Astronomical Society 453 (2015) 2465–2470. date_created: 2022-07-14T08:58:36Z date_published: 2015-11-01T00:00:00Z date_updated: 2022-08-19T08:19:23Z day: '01' doi: 10.1093/mnras/stv1795 extern: '1' external_id: arxiv: - '1506.07173' intvolume: ' 453' issue: '3' keyword: - Space and Planetary Science - Astronomy and Astrophysics - black hole physics - 'stars: Population III' - 'galaxies: high-redshift' language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/1506.07173 month: '11' oa: 1 oa_version: Preprint page: 2465-2470 publication: Monthly Notices of the Royal Astronomical Society publication_identifier: eissn: - 1365-2966 issn: - 0035-8711 publication_status: published publisher: Oxford University Press quality_controlled: '1' scopus_import: '1' status: public title: 'The brightest Lyα emitter: Pop III or black hole?' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 453 year: '2015' ... --- _id: '11580' abstract: - lang: eng text: 'We present results from the largest contiguous narrow-band survey in the near-infrared. We have used the wide-field infrared camera/Canada–France–Hawaii Telescope and the lowOH2 filter (1.187 ± 0.005 μm) to survey ≈10 deg2 of contiguous extragalactic sky in the SA22 field. A total of ∼6000 candidate emission-line galaxies are found. We use deep ugrizJK data to obtain robust photometric redshifts. We combine our data with the High-redshift(Z) Emission Line Survey (HiZELS), explore spectroscopic surveys (VVDS, VIPERS) and obtain our own spectroscopic follow-up with KMOS, FMOS and MOSFIRE to derive large samples of high-redshift emission-line selected galaxies: 3471 Hα emitters at z = 0.8, 1343 [O III] + Hβ emitters at z = 1.4 and 572 [O II] emitters at z = 2.2. We probe comoving volumes of >106 Mpc3 and find significant overdensities, including an 8.5σ (spectroscopically confirmed) overdensity of Hα emitters at z = 0.81. We derive Hα, [O III] + Hβ and [O II] luminosity functions at z = 0.8, 1.4, 2.2, respectively, and present implications for future surveys such as Euclid. Our uniquely large volumes/areas allow us to subdivide the samples in thousands of randomized combinations of areas and provide a robust empirical measurement of sample/cosmic variance. We show that surveys for star-forming/emission-line galaxies at a depth similar to ours can only overcome cosmic-variance (errors <10 per cent) if they are based on volumes >5 × 105 Mpc3; errors on L* and ϕ* due to sample (cosmic) variance on surveys probing ∼104 and ∼105 Mpc3 are typically very high: ∼300 and ∼40–60 per cent, respectively.' acknowledgement: The authors wish to thank the anonymous reviewer for many helpful comments and suggestions which greatly improved the clarity and quality of this work. DS acknowledges financial support from the Netherlands Organization for Scientific research (NWO) through a Veni fellowship, from FCT through an FCT Investigator Starting Grant and Start-up Grant (IF/01154/2012/CP0189/CT0010), from FCT grant PEst-OE/FIS/UI2751/2014, and from LSF and LKBF. JM acknowledges the award of a Huygens PhD fellowship. PNB is grateful for support from STFC. IRS acknowledges support from STFC, a Leverhulme Fellowship, the ERC Advanced Investigator programme DUSTYGAL and a Royal Society/Wolfson Merit Award. BMJ acknowledges support from the ERC-StG grant EGGS-278202. The Dark Cosmology Centre is funded by the DNRF. The Dark Cosmology Centre is funded by the DNRF. JWK acknowledges support from the National Research Foundation of Korea (NRF) grant, no. 2008-0060544, funded by the Korea government (MSIP). JPS acknowledges support from STFC (ST/I001573/1). JC acknowledges support from the FCT-IF grant IF/01154/2012/CP0189/CT0010. The work was only possible due to OPTICON/FP7 and the invaluable access that it granted to the CFHT telescope. We would also like to acknowledge the excellent work done by CFHT staff in conducting the observations in service mode, and on delivering truly excellent data. We are also tremendously thankful to Kentaro Aoki for the incredible support while observing at Subaru with FMOS, and also to the Keck staff for the help with the observations with MOSFIRE. This work is based on observations obtained with WIRCam on the CFHT, OPTICON programme 2011B/029, 2012A019 and 2012B/016. Based on observations made with ESO telescopes at the La Silla Paranal Observatory under programmes IDs 60.A-9460 (data can be accessed through the ESO data archive), 087.A 0337 and 089.A-0965. Based on observations done with FMOS on Subaru under programme S14A-084, and on MOSFIRE/Keck observations under programme U066M. Part of the data on which this analysis is based are available from Sobral et al. (2013a). Dedicated to the memory of C. M. Sobral (1953-2014). article_processing_charge: No article_type: original arxiv: 1 author: - first_name: D. full_name: Sobral, D. last_name: Sobral - first_name: Jorryt J full_name: Matthee, Jorryt J id: 7439a258-f3c0-11ec-9501-9df22fe06720 last_name: Matthee orcid: 0000-0003-2871-127X - first_name: P. N. full_name: Best, P. N. last_name: Best - first_name: I. full_name: Smail, I. last_name: Smail - first_name: A. A. full_name: Khostovan, A. A. last_name: Khostovan - first_name: B. full_name: Milvang-Jensen, B. last_name: Milvang-Jensen - first_name: J.-W. full_name: Kim, J.-W. last_name: Kim - first_name: J. full_name: Stott, J. last_name: Stott - first_name: J. full_name: Calhau, J. last_name: Calhau - first_name: H. full_name: Nayyeri, H. last_name: Nayyeri - first_name: B. full_name: Mobasher, B. last_name: Mobasher citation: ama: 'Sobral D, Matthee JJ, Best PN, et al. CF-HiZELS, an ∼10 deg2 emission-line survey with spectroscopic follow-up: Hα, [O III] + Hβ and [O II] luminosity functions at z = 0.8, 1.4 and 2.2 . Monthly Notices of the Royal Astronomical Society. 2015;451(3):2303-2323. doi:10.1093/mnras/stv1076' apa: 'Sobral, D., Matthee, J. J., Best, P. N., Smail, I., Khostovan, A. A., Milvang-Jensen, B., … Mobasher, B. (2015). CF-HiZELS, an ∼10 deg2 emission-line survey with spectroscopic follow-up: Hα, [O III] + Hβ and [O II] luminosity functions at z = 0.8, 1.4 and 2.2 . Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/stv1076' chicago: 'Sobral, D., Jorryt J Matthee, P. N. Best, I. Smail, A. A. Khostovan, B. Milvang-Jensen, J.-W. Kim, et al. “CF-HiZELS, an ∼10 Deg2 Emission-Line Survey with Spectroscopic Follow-up: Hα, [O III] + Hβ and [O II] Luminosity Functions at z = 0.8, 1.4 and 2.2 .” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2015. https://doi.org/10.1093/mnras/stv1076.' ieee: 'D. Sobral et al., “CF-HiZELS, an ∼10 deg2 emission-line survey with spectroscopic follow-up: Hα, [O III] + Hβ and [O II] luminosity functions at z = 0.8, 1.4 and 2.2 ,” Monthly Notices of the Royal Astronomical Society, vol. 451, no. 3. Oxford University Press, pp. 2303–2323, 2015.' ista: 'Sobral D, Matthee JJ, Best PN, Smail I, Khostovan AA, Milvang-Jensen B, Kim J-W, Stott J, Calhau J, Nayyeri H, Mobasher B. 2015. CF-HiZELS, an ∼10 deg2 emission-line survey with spectroscopic follow-up: Hα, [O III] + Hβ and [O II] luminosity functions at z = 0.8, 1.4 and 2.2 . Monthly Notices of the Royal Astronomical Society. 451(3), 2303–2323.' mla: 'Sobral, D., et al. “CF-HiZELS, an ∼10 Deg2 Emission-Line Survey with Spectroscopic Follow-up: Hα, [O III] + Hβ and [O II] Luminosity Functions at z = 0.8, 1.4 and 2.2 .” Monthly Notices of the Royal Astronomical Society, vol. 451, no. 3, Oxford University Press, 2015, pp. 2303–23, doi:10.1093/mnras/stv1076.' short: D. Sobral, J.J. Matthee, P.N. Best, I. Smail, A.A. Khostovan, B. Milvang-Jensen, J.-W. Kim, J. Stott, J. Calhau, H. Nayyeri, B. Mobasher, Monthly Notices of the Royal Astronomical Society 451 (2015) 2303–2323. date_created: 2022-07-14T09:02:22Z date_published: 2015-08-11T00:00:00Z date_updated: 2024-10-14T11:36:57Z day: '11' doi: 10.1093/mnras/stv1076 extern: '1' external_id: arxiv: - '1502.06602' intvolume: ' 451' issue: '3' keyword: - Space and Planetary Science - Astronomy and Astrophysics - 'galaxies: evolution' - 'galaxies: formation' - 'galaxies: luminosity function' - mass function - 'cosmology: observations' - early Universe - large-scale structure of Universe language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/1502.06602 month: '08' oa: 1 oa_version: Preprint page: 2303-2323 publication: Monthly Notices of the Royal Astronomical Society publication_identifier: eissn: - 1365-2966 issn: - 0035-8711 publication_status: published publisher: Oxford University Press quality_controlled: '1' scopus_import: '1' status: public title: 'CF-HiZELS, an ∼10 deg2 emission-line survey with spectroscopic follow-up: Hα, [O III] + Hβ and [O II] luminosity functions at z = 0.8, 1.4 and 2.2 ' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 451 year: '2015' ... --- _id: '11581' abstract: - lang: eng text: Using wide-field narrow-band surveys, we provide a new measurement of the z = 6.6 Lymanα emitter (LAE) luminosity function (LF), which constraints the bright end for the first time. We use a combination of archival narrow-band NB921 data in UDS and new NB921 measurements in SA22 and COSMOS/UltraVISTA, all observed with the Subaru telescope, with a total area of ∼5 deg2. We exclude lower redshift interlopers by using broad-band optical and near-infrared photometry and also exclude three supernovae with data split over multiple epochs. Combining the UDS and COSMOS samples, we find no evolution of the bright end of the Lyα LF between z = 5.7 and 6.6, which is supported by spectroscopic follow-up, and conclude that sources with Himiko-like luminosity are not as rare as previously thought, with number densities of ∼1.5 × 10−5 Mpc−3. Combined with our wide-field SA22 measurements, our results indicate a non-Schechter-like bright end of the LF at z = 6.6 and a different evolution of observed faint and bright LAEs, overcoming cosmic variance. This differential evolution is also seen in the spectroscopic follow-up of UV-selected galaxies and is now also confirmed for LAEs, and we argue that it may be an effect of reionization. Using a toy model, we show that such differential evolution of the LF is expected, since brighter sources are able to ionize their surroundings earlier, such that Lyα photons are able to escape. Our targets are excellent candidates for detailed follow-up studies and provide the possibility to give a unique view on the earliest stages in the formation of galaxies and reionization process. acknowledgement: "We thank the anonymous referee for the comments and suggestions which have improved the quality of this work. We thank Masami Ouchi for his useful comments on an earlier version of this paper. JM acknowledges the support of a Huygens PhD fellowship from Leiden University and is thankful for the hospitality of the Center for Astronomy and Astrophysics of the University of Lisbon where part of this research has been done. DS acknowledges financial support from the Netherlands Organization for Scientific research (NWO) through a Veni fellowship, from FCT through a FCT Investigator Starting Grant and Start-up Grant (IF/01154/2012/CP0189/CT0010) and from FCT grant PEstOE/FIS/UI2751/2014. HR acknowledges support from the ERC Advanced Investigator programme NewClusters 321271. We acknowledge the award of ESO DDT time (294.A-5018) for providing the possibility of a timely publication of this work.\r\nBased on observations with the Subaru Telescope (Programme IDs: our observations: S14A-086; archival: S05B-027, S06A-025, S06B-010, S07A-013, S07B-008, S08B-008 and S09A-017) and the W.M. Keck Observatory. The Subaru telescope is operated by the National Astronomical Observatory of Japan. The W.M. Keck Observatory is operated as a scientific partnership among the California Institute of Technology, the University of California and the National Aeronautics and Space Administration. Based on observations made with ESO Telescopes at the La Silla Paranal Observatory under programme ID 294.A-5018. Based on observations obtained with MegaPrime/Megacam, a joint project of CFHT and CEA/IRFU, at the Canada–France-Hawaii Telescope (CFHT) which is operated by the National Research Council (NRC) of Canada, the Institut National des Science de l’Univers of the Centre National de la Recherche Scientifique (CNRS) of France, and the University of Hawaii. This work is based in part on data products produced at Terapix available at the Canadian Astronomy Data Centre as part of the CFHT Legacy Survey, a collaborative project of NRC and CNRS. Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under ESO programme ID 179.A-2005 and on data products produced by TERAPIX and the Cambridge Astronomy Survey Unit on behalf of the UltraVISTA consortium.\r\nIn addition to the CFHT-LS and COSMOS-UltraVISTA surveys, we are grateful for the excellent data sets from the UKIRT-DXS, SXDF and S-COSMOS survey teams, without these legacy surveys, this research would have been impossible. We have benefited greatly from the public available programming language PYTHON, including the NUMPY, MATPLOTLIB, PYFITS, SCIPY and ASTROPY packages, the astronomical imaging tools SEXTRACTOR, SWARP and SCAMP and the indispensable TOPCAT analysis tool (Taylor 2013)" article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Jorryt J full_name: Matthee, Jorryt J id: 7439a258-f3c0-11ec-9501-9df22fe06720 last_name: Matthee orcid: 0000-0003-2871-127X - first_name: David full_name: Sobral, David last_name: Sobral - first_name: Sérgio full_name: Santos, Sérgio last_name: Santos - first_name: Huub full_name: Röttgering, Huub last_name: Röttgering - first_name: Behnam full_name: Darvish, Behnam last_name: Darvish - first_name: Bahram full_name: Mobasher, Bahram last_name: Mobasher citation: ama: 'Matthee JJ, Sobral D, Santos S, Röttgering H, Darvish B, Mobasher B. Identification of the brightest Lyα emitters at z = 6.6: implications for the evolution of the luminosity function in the reionization era. Monthly Notices of the Royal Astronomical Society. 2015;451(1):400-417. doi:10.1093/mnras/stv947' apa: 'Matthee, J. J., Sobral, D., Santos, S., Röttgering, H., Darvish, B., & Mobasher, B. (2015). Identification of the brightest Lyα emitters at z = 6.6: implications for the evolution of the luminosity function in the reionization era. Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/stv947' chicago: 'Matthee, Jorryt J, David Sobral, Sérgio Santos, Huub Röttgering, Behnam Darvish, and Bahram Mobasher. “Identification of the Brightest Lyα Emitters at z = 6.6: Implications for the Evolution of the Luminosity Function in the Reionization Era.” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2015. https://doi.org/10.1093/mnras/stv947.' ieee: 'J. J. Matthee, D. Sobral, S. Santos, H. Röttgering, B. Darvish, and B. Mobasher, “Identification of the brightest Lyα emitters at z = 6.6: implications for the evolution of the luminosity function in the reionization era,” Monthly Notices of the Royal Astronomical Society, vol. 451, no. 1. Oxford University Press, pp. 400–417, 2015.' ista: 'Matthee JJ, Sobral D, Santos S, Röttgering H, Darvish B, Mobasher B. 2015. Identification of the brightest Lyα emitters at z = 6.6: implications for the evolution of the luminosity function in the reionization era. Monthly Notices of the Royal Astronomical Society. 451(1), 400–417.' mla: 'Matthee, Jorryt J., et al. “Identification of the Brightest Lyα Emitters at z = 6.6: Implications for the Evolution of the Luminosity Function in the Reionization Era.” Monthly Notices of the Royal Astronomical Society, vol. 451, no. 1, Oxford University Press, 2015, pp. 400–17, doi:10.1093/mnras/stv947.' short: J.J. Matthee, D. Sobral, S. Santos, H. Röttgering, B. Darvish, B. Mobasher, Monthly Notices of the Royal Astronomical Society 451 (2015) 400–417. date_created: 2022-07-14T11:57:03Z date_published: 2015-07-21T00:00:00Z date_updated: 2024-10-14T11:37:15Z day: '21' doi: 10.1093/mnras/stv947 extern: '1' external_id: arxiv: - '1502.07355' intvolume: ' 451' issue: '1' keyword: - Space and Planetary Science - Astronomy and Astrophysics language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/1502.07355 month: '07' oa: 1 oa_version: Preprint page: 400-417 publication: Monthly Notices of the Royal Astronomical Society publication_identifier: eissn: - 1365-2966 issn: - 0035-8711 publication_status: published publisher: Oxford University Press quality_controlled: '1' scopus_import: '1' status: public title: 'Identification of the brightest Lyα emitters at z = 6.6: implications for the evolution of the luminosity function in the reionization era' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 451 year: '2015' ... --- _id: '11668' abstract: - lang: eng text: "We study multiple keyword sponsored search auctions with budgets. Each keyword has multiple ad slots with a click-through rate. The bidders have additive valuations, which are linear in the click-through rates, and budgets, which are restricting their overall payments. Additionally, the number of slots per keyword assigned to a bidder is bounded.\r\n\r\nWe show the following results: (1) We give the first mechanism for multiple keywords, where click-through rates differ among slots. Our mechanism is incentive compatible in expectation, individually rational in expectation, and Pareto optimal. (2) We study the combinatorial setting, where each bidder is only interested in a subset of the keywords. We give an incentive compatible, individually rational, Pareto-optimal, and deterministic mechanism for identical click-through rates. (3) We give an impossibility result for incentive compatible, individually rational, Pareto-optimal, and deterministic mechanisms for bidders with diminishing marginal valuations." article_number: '2' article_processing_charge: No article_type: original author: - first_name: Riccardo full_name: Colini-Baldeschi, Riccardo last_name: Colini-Baldeschi - first_name: Stefano full_name: Leonardi, Stefano last_name: Leonardi - first_name: Monika H full_name: Henzinger, Monika H id: 540c9bbd-f2de-11ec-812d-d04a5be85630 last_name: Henzinger orcid: 0000-0002-5008-6530 - first_name: Martin full_name: Starnberger, Martin last_name: Starnberger citation: ama: Colini-Baldeschi R, Leonardi S, Henzinger M, Starnberger M. On multiple keyword sponsored search auctions with budgets. ACM Transactions on Economics and Computation. 2015;4(1). doi:10.1145/2818357 apa: Colini-Baldeschi, R., Leonardi, S., Henzinger, M., & Starnberger, M. (2015). On multiple keyword sponsored search auctions with budgets. ACM Transactions on Economics and Computation. Association for Computing Machinery. https://doi.org/10.1145/2818357 chicago: Colini-Baldeschi, Riccardo, Stefano Leonardi, Monika Henzinger, and Martin Starnberger. “On Multiple Keyword Sponsored Search Auctions with Budgets.” ACM Transactions on Economics and Computation. Association for Computing Machinery, 2015. https://doi.org/10.1145/2818357. ieee: R. Colini-Baldeschi, S. Leonardi, M. Henzinger, and M. Starnberger, “On multiple keyword sponsored search auctions with budgets,” ACM Transactions on Economics and Computation, vol. 4, no. 1. Association for Computing Machinery, 2015. ista: Colini-Baldeschi R, Leonardi S, Henzinger M, Starnberger M. 2015. On multiple keyword sponsored search auctions with budgets. ACM Transactions on Economics and Computation. 4(1), 2. mla: Colini-Baldeschi, Riccardo, et al. “On Multiple Keyword Sponsored Search Auctions with Budgets.” ACM Transactions on Economics and Computation, vol. 4, no. 1, 2, Association for Computing Machinery, 2015, doi:10.1145/2818357. short: R. Colini-Baldeschi, S. Leonardi, M. Henzinger, M. Starnberger, ACM Transactions on Economics and Computation 4 (2015). date_created: 2022-07-27T11:54:56Z date_published: 2015-12-05T00:00:00Z date_updated: 2024-11-06T12:06:41Z day: '05' doi: 10.1145/2818357 extern: '1' intvolume: ' 4' issue: '1' keyword: - Algorithms - Economics - Clinching ascending auction - auctions with budgets - Sponsored search auctions language: - iso: eng main_file_link: - open_access: '1' url: http://eprints.cs.univie.ac.at/3510/ month: '12' oa: 1 oa_version: Submitted Version publication: ACM Transactions on Economics and Computation publication_identifier: eissn: - 2167-8383 issn: - 2167-8375 publication_status: published publisher: Association for Computing Machinery quality_controlled: '1' scopus_import: '1' status: public title: On multiple keyword sponsored search auctions with budgets type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 4 year: '2015' ... --- _id: '11669' abstract: - lang: eng text: We study individual rational, Pareto-optimal, and incentive compatible mechanisms for auctions with heterogeneous items and budget limits. We consider settings with multiunit demand and additive valuations. For single-dimensional valuations we prove a positive result for randomized mechanisms, and a negative result for deterministic mechanisms. While the positive result allows for private budgets, the negative result is for public budgets. For multidimensional valuations and public budgets we prove an impossibility result that applies to deterministic and randomized mechanisms. Taken together this shows the power of randomization in certain settings with heterogeneous items, but it also shows its limitations. article_number: '4' article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Paul full_name: Dütting, Paul last_name: Dütting - first_name: Monika H full_name: Henzinger, Monika H id: 540c9bbd-f2de-11ec-812d-d04a5be85630 last_name: Henzinger orcid: 0000-0002-5008-6530 - first_name: Martin full_name: Starnberger, Martin last_name: Starnberger citation: ama: Dütting P, Henzinger M, Starnberger M. Auctions for heterogeneous items and budget limits. ACM Transactions on Economics and Computation. 2015;4(1). doi:10.1145/2818351 apa: Dütting, P., Henzinger, M., & Starnberger, M. (2015). Auctions for heterogeneous items and budget limits. ACM Transactions on Economics and Computation. Association for Computing Machinery. https://doi.org/10.1145/2818351 chicago: Dütting, Paul, Monika Henzinger, and Martin Starnberger. “Auctions for Heterogeneous Items and Budget Limits.” ACM Transactions on Economics and Computation. Association for Computing Machinery, 2015. https://doi.org/10.1145/2818351. ieee: P. Dütting, M. Henzinger, and M. Starnberger, “Auctions for heterogeneous items and budget limits,” ACM Transactions on Economics and Computation, vol. 4, no. 1. Association for Computing Machinery, 2015. ista: Dütting P, Henzinger M, Starnberger M. 2015. Auctions for heterogeneous items and budget limits. ACM Transactions on Economics and Computation. 4(1), 4. mla: Dütting, Paul, et al. “Auctions for Heterogeneous Items and Budget Limits.” ACM Transactions on Economics and Computation, vol. 4, no. 1, 4, Association for Computing Machinery, 2015, doi:10.1145/2818351. short: P. Dütting, M. Henzinger, M. Starnberger, ACM Transactions on Economics and Computation 4 (2015). date_created: 2022-07-27T12:09:15Z date_published: 2015-12-05T00:00:00Z date_updated: 2024-11-06T12:06:53Z day: '05' doi: 10.1145/2818351 extern: '1' external_id: arxiv: - '1209.6448' intvolume: ' 4' issue: '1' keyword: - Algorithmic game theory - auction theory - Clinching auction - Pareto optimality - Budget limits language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/1209.6448 month: '12' oa: 1 oa_version: Preprint publication: ACM Transactions on Economics and Computation publication_identifier: eissn: - 2167-8383 issn: - 2167-8375 publication_status: published publisher: Association for Computing Machinery quality_controlled: '1' scopus_import: '1' status: public title: Auctions for heterogeneous items and budget limits type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 4 year: '2015' ...