---
OA_place: repository
OA_type: green
_id: '1729'
abstract:
- lang: eng
  text: We present a computer-aided programming approach to concurrency. The approach
    allows programmers to program assuming a friendly, non-preemptive scheduler, and
    our synthesis procedure inserts synchronization to ensure that the final program
    works even with a preemptive scheduler. The correctness specification is implicit,
    inferred from the non-preemptive behavior. Let us consider sequences of calls
    that the program makes to an external interface. The specification requires that
    any such sequence produced under a preemptive scheduler should be included in
    the set of such sequences produced under a non-preemptive scheduler. The solution
    is based on a finitary abstraction, an algorithm for bounded language inclusion
    modulo an independence relation, and rules for inserting synchronization. We apply
    the approach to device-driver programming, where the driver threads call the software
    interface of the device and the API provided by the operating system. Our experiments
    demonstrate that our synthesis method is precise and efficient, and, since it
    does not require explicit specifications, is more practical than the conventional
    approach based on user-provided assertions.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Pavol
  full_name: Cerny, Pavol
  id: 4DCBEFFE-F248-11E8-B48F-1D18A9856A87
  last_name: Cerny
- first_name: Edmund
  full_name: Clarke, Edmund
  last_name: Clarke
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Arjun
  full_name: Radhakrishna, Arjun
  id: 3B51CAC4-F248-11E8-B48F-1D18A9856A87
  last_name: Radhakrishna
- first_name: Leonid
  full_name: Ryzhyk, Leonid
  last_name: Ryzhyk
- first_name: Roopsha
  full_name: Samanta, Roopsha
  id: 3D2AAC08-F248-11E8-B48F-1D18A9856A87
  last_name: Samanta
- first_name: Thorsten
  full_name: Tarrach, Thorsten
  id: 3D6E8F2C-F248-11E8-B48F-1D18A9856A87
  last_name: Tarrach
  orcid: 0000-0003-4409-8487
citation:
  ama: Cerny P, Clarke E, Henzinger TA, et al. From non-preemptive to preemptive scheduling
    using synchronization synthesis. 2015;9207:180-197. doi:<a href="https://doi.org/10.1007/978-3-319-21668-3_11">10.1007/978-3-319-21668-3_11</a>
  apa: 'Cerny, P., Clarke, E., Henzinger, T. A., Radhakrishna, A., Ryzhyk, L., Samanta,
    R., &#38; Tarrach, T. (2015). From non-preemptive to preemptive scheduling using
    synchronization synthesis. Presented at the CAV: Computer Aided Verification,
    San Francisco, CA, United States: Springer. <a href="https://doi.org/10.1007/978-3-319-21668-3_11">https://doi.org/10.1007/978-3-319-21668-3_11</a>'
  chicago: Cerny, Pavol, Edmund Clarke, Thomas A Henzinger, Arjun Radhakrishna, Leonid
    Ryzhyk, Roopsha Samanta, and Thorsten Tarrach. “From Non-Preemptive to Preemptive
    Scheduling Using Synchronization Synthesis.” Lecture Notes in Computer Science.
    Springer, 2015. <a href="https://doi.org/10.1007/978-3-319-21668-3_11">https://doi.org/10.1007/978-3-319-21668-3_11</a>.
  ieee: P. Cerny <i>et al.</i>, “From non-preemptive to preemptive scheduling using
    synchronization synthesis,” vol. 9207. Springer, pp. 180–197, 2015.
  ista: Cerny P, Clarke E, Henzinger TA, Radhakrishna A, Ryzhyk L, Samanta R, Tarrach
    T. 2015. From non-preemptive to preemptive scheduling using synchronization synthesis.
    9207, 180–197.
  mla: Cerny, Pavol, et al. <i>From Non-Preemptive to Preemptive Scheduling Using
    Synchronization Synthesis</i>. Vol. 9207, Springer, 2015, pp. 180–97, doi:<a href="https://doi.org/10.1007/978-3-319-21668-3_11">10.1007/978-3-319-21668-3_11</a>.
  short: P. Cerny, E. Clarke, T.A. Henzinger, A. Radhakrishna, L. Ryzhyk, R. Samanta,
    T. Tarrach, 9207 (2015) 180–197.
conference:
  end_date: 2015-07-24
  location: San Francisco, CA, United States
  name: 'CAV: Computer Aided Verification'
  start_date: 2015-07-18
date_created: 2018-12-11T11:53:42Z
date_published: 2015-07-01T00:00:00Z
date_updated: 2026-04-09T10:54:00Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1007/978-3-319-21668-3_11
ec_funded: 1
external_id:
  isi:
  - '000491470400011'
file:
- access_level: open_access
  checksum: 6ff58ac220e2f20cb001ba35d4924495
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:08:53Z
  date_updated: 2025-06-26T07:12:35Z
  file_id: '4715'
  file_name: IST-2015-336-v1+1_long_version.pdf
  file_size: 481922
  relation: main_file
file_date_updated: 2025-06-26T07:12:35Z
has_accepted_license: '1'
intvolume: '      9207'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Submitted Version
page: 180 - 197
project:
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '267989'
  name: Quantitative Reactive Modeling
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z211
  name: Formal methods for the design and analysis of complex systems
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
publication_status: published
publisher: Springer
publist_id: '5398'
pubrep_id: '336'
quality_controlled: '1'
related_material:
  record:
  - id: '1338'
    relation: later_version
    status: public
  - id: '1130'
    relation: dissertation_contains
    status: public
scopus_import: '1'
series_title: Lecture Notes in Computer Science
status: public
title: From non-preemptive to preemptive scheduling using synchronization synthesis
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 9207
year: '2015'
...
---
_id: '1666'
abstract:
- lang: eng
  text: Evolution of gene regulation is crucial for our understanding of the phenotypic
    differences between species, populations and individuals. Sequence-specific binding
    of transcription factors to the regulatory regions on the DNA is a key regulatory
    mechanism that determines gene expression and hence heritable phenotypic variation.
    We use a biophysical model for directional selection on gene expression to estimate
    the rates of gain and loss of transcription factor binding sites (TFBS) in finite
    populations under both point and insertion/deletion mutations. Our results show
    that these rates are typically slow for a single TFBS in an isolated DNA region,
    unless the selection is extremely strong. These rates decrease drastically with
    increasing TFBS length or increasingly specific protein-DNA interactions, making
    the evolution of sites longer than ∼ 10 bp unlikely on typical eukaryotic speciation
    timescales. Similarly, evolution converges to the stationary distribution of binding
    sequences very slowly, making the equilibrium assumption questionable. The availability
    of longer regulatory sequences in which multiple binding sites can evolve simultaneously,
    the presence of “pre-sites” or partially decayed old sites in the initial sequence,
    and biophysical cooperativity between transcription factors, can all facilitate
    gain of TFBS and reconcile theoretical calculations with timescales inferred from
    comparative genomics.
article_processing_charge: No
author:
- first_name: Murat
  full_name: Tugrul, Murat
  id: 37C323C6-F248-11E8-B48F-1D18A9856A87
  last_name: Tugrul
  orcid: 0000-0002-8523-0758
- first_name: Tiago
  full_name: Paixao, Tiago
  id: 2C5658E6-F248-11E8-B48F-1D18A9856A87
  last_name: Paixao
  orcid: 0000-0003-2361-3953
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Gasper
  full_name: Tkacik, Gasper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkacik
  orcid: 0000-0002-6699-1455
citation:
  ama: Tugrul M, Paixao T, Barton NH, Tkačik G. Dynamics of transcription factor binding
    site evolution. <i>PLoS Genetics</i>. 2015;11(11). doi:<a href="https://doi.org/10.1371/journal.pgen.1005639">10.1371/journal.pgen.1005639</a>
  apa: Tugrul, M., Paixao, T., Barton, N. H., &#38; Tkačik, G. (2015). Dynamics of
    transcription factor binding site evolution. <i>PLoS Genetics</i>. Public Library
    of Science. <a href="https://doi.org/10.1371/journal.pgen.1005639">https://doi.org/10.1371/journal.pgen.1005639</a>
  chicago: Tugrul, Murat, Tiago Paixao, Nicholas H Barton, and Gašper Tkačik. “Dynamics
    of Transcription Factor Binding Site Evolution.” <i>PLoS Genetics</i>. Public
    Library of Science, 2015. <a href="https://doi.org/10.1371/journal.pgen.1005639">https://doi.org/10.1371/journal.pgen.1005639</a>.
  ieee: M. Tugrul, T. Paixao, N. H. Barton, and G. Tkačik, “Dynamics of transcription
    factor binding site evolution,” <i>PLoS Genetics</i>, vol. 11, no. 11. Public
    Library of Science, 2015.
  ista: Tugrul M, Paixao T, Barton NH, Tkačik G. 2015. Dynamics of transcription factor
    binding site evolution. PLoS Genetics. 11(11).
  mla: Tugrul, Murat, et al. “Dynamics of Transcription Factor Binding Site Evolution.”
    <i>PLoS Genetics</i>, vol. 11, no. 11, Public Library of Science, 2015, doi:<a
    href="https://doi.org/10.1371/journal.pgen.1005639">10.1371/journal.pgen.1005639</a>.
  short: M. Tugrul, T. Paixao, N.H. Barton, G. Tkačik, PLoS Genetics 11 (2015).
date_created: 2018-12-11T11:53:21Z
date_published: 2015-11-06T00:00:00Z
date_updated: 2026-04-09T10:52:40Z
day: '06'
ddc:
- '576'
department:
- _id: NiBa
- _id: CaGu
- _id: GaTk
doi: 10.1371/journal.pgen.1005639
ec_funded: 1
external_id:
  isi:
  - '000366179000022'
file:
- access_level: open_access
  checksum: a4e72fca5ccf40ddacf4d08c8e46b554
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:07:58Z
  date_updated: 2020-07-14T12:45:10Z
  file_id: '4657'
  file_name: IST-2016-463-v1+1_journal.pgen.1005639.pdf
  file_size: 2580778
  relation: main_file
file_date_updated: 2020-07-14T12:45:10Z
has_accepted_license: '1'
intvolume: '        11'
isi: 1
issue: '11'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '250152'
  name: Limits to selection in biology and in evolutionary computation
publication: PLoS Genetics
publication_status: published
publisher: Public Library of Science
publist_id: '5483'
pubrep_id: '463'
quality_controlled: '1'
related_material:
  record:
  - id: '9712'
    relation: research_data
    status: public
  - id: '1131'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Dynamics of transcription factor binding site evolution
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 11
year: '2015'
...
---
OA_place: publisher
_id: '1401'
abstract:
- lang: eng
  text: 'The human ability to recognize objects in complex scenes has driven research
    in the computer vision field over couple of decades. This thesis focuses on the
    object recognition task in images. That is, given the image, we want the computer
    system to be able to predict the class of the object that appears in the image.
    A recent successful attempt to bridge semantic understanding of the image perceived
    by humans and by computers uses attribute-based models. Attributes are semantic
    properties of the objects shared across different categories, which humans and
    computers can decide on. To explore the attribute-based models we take a statistical
    machine learning approach, and address two key learning challenges in view of
    object recognition task: learning augmented attributes as mid-level discriminative
    feature representation, and learning with attributes as privileged information.
    Our main contributions are parametric and non-parametric models and algorithms
    to solve these frameworks. In the parametric approach, we explore an autoencoder
    model combined with the large margin nearest neighbor principle for mid-level
    feature learning, and linear support vector machines for learning with privileged
    information. In the non-parametric approach, we propose a supervised Indian Buffet
    Process for automatic augmentation of semantic attributes, and explore the Gaussian
    Processes classification framework for learning with privileged information. A
    thorough experimental analysis shows the effectiveness of the proposed models
    in both parametric and non-parametric views.'
acknowledgement: "I would like to thank my supervisor, Christoph Lampert, for guidance
  throughout my studies and for patience in transforming me into a scientist, and
  my thesis committee, Chris Wojtan and Horst Bischof, for their help and advice.
  \r\n\r\nI would like to thank Elisabeth Hacker who perfectly assisted all my administrative
  needs and was always nice and friendly to me, and the campus team for making the
  IST Austria campus my second home. \r\nI was honored to collaborate with brilliant
  researchers and to learn from their experience. Undoubtedly, I learned most of all
  from Novi Quadrianto: brainstorming our projects and getting exciting results was
  the most enjoyable part of my work – thank you! I am also grateful to David Knowles,
  Zoubin Ghahramani, Daniel Hernández-Lobato, Kristian Kersting and Anastasia Pentina
  for the fantastic projects we worked on together, and to Kristen Grauman and Adriana
  Kovashka for the exceptional experience working with user studies. I would like
  to thank my colleagues at IST Austria and my office mates who shared their happy
  moods, scientific breakthroughs and thought-provoking conversations with me: Chao,
  Filip, Rustem, Asya, Sameh, Alex, Vlad, Mayu, Neel, Csaba, Thomas, Vladimir, Cristina,
  Alex Z., Avro, Amelie and Emilie, Andreas H. and Andreas E., Chris, Lena, Michael,
  Ali and Ipek, Vera, Igor, Katia. Special thanks to Morten for the countless games
  of table soccer we played together and the tournaments we teamed up for: we will
  definitely win next time:) A very warm hug to Asya for always being so inspiring
  and supportive to me, and for helping me to increase the proportion of female computer
  scientists in our group. "
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Viktoriia
  full_name: Sharmanska, Viktoriia
  id: 2EA6D09E-F248-11E8-B48F-1D18A9856A87
  last_name: Sharmanska
  orcid: 0000-0003-0192-9308
citation:
  ama: 'Sharmanska V. Learning with attributes for object recognition: Parametric
    and non-parametrics views. 2015. doi:<a href="https://doi.org/10.15479/at:ista:1401">10.15479/at:ista:1401</a>'
  apa: 'Sharmanska, V. (2015). <i>Learning with attributes for object recognition:
    Parametric and non-parametrics views</i>. Institute of Science and Technology
    Austria. <a href="https://doi.org/10.15479/at:ista:1401">https://doi.org/10.15479/at:ista:1401</a>'
  chicago: 'Sharmanska, Viktoriia. “Learning with Attributes for Object Recognition:
    Parametric and Non-Parametrics Views.” Institute of Science and Technology Austria,
    2015. <a href="https://doi.org/10.15479/at:ista:1401">https://doi.org/10.15479/at:ista:1401</a>.'
  ieee: 'V. Sharmanska, “Learning with attributes for object recognition: Parametric
    and non-parametrics views,” Institute of Science and Technology Austria, 2015.'
  ista: 'Sharmanska V. 2015. Learning with attributes for object recognition: Parametric
    and non-parametrics views. Institute of Science and Technology Austria.'
  mla: 'Sharmanska, Viktoriia. <i>Learning with Attributes for Object Recognition:
    Parametric and Non-Parametrics Views</i>. Institute of Science and Technology
    Austria, 2015, doi:<a href="https://doi.org/10.15479/at:ista:1401">10.15479/at:ista:1401</a>.'
  short: 'V. Sharmanska, Learning with Attributes for Object Recognition: Parametric
    and Non-Parametrics Views, Institute of Science and Technology Austria, 2015.'
corr_author: '1'
date_created: 2018-12-11T11:51:48Z
date_published: 2015-04-01T00:00:00Z
date_updated: 2026-04-09T14:25:49Z
day: '01'
ddc:
- '000'
degree_awarded: PhD
department:
- _id: ChLa
- _id: GradSch
doi: 10.15479/at:ista:1401
file:
- access_level: open_access
  checksum: 3605b402bb6934e09ae4cf672c84baf7
  content_type: application/pdf
  creator: dernst
  date_created: 2021-02-22T11:33:17Z
  date_updated: 2021-02-22T11:33:17Z
  file_id: '9177'
  file_name: 2015_Thesis_Sharmanska.pdf
  file_size: 7964342
  relation: main_file
  success: 1
- access_level: closed
  checksum: e37593b3ee75bf3180629df2d6ca8f4e
  content_type: application/pdf
  creator: cchlebak
  date_created: 2021-11-16T14:40:45Z
  date_updated: 2021-11-17T13:47:24Z
  file_id: '10297'
  file_name: 2015_Thesis_Sharmanska_pdfa.pdf
  file_size: 7372241
  relation: main_file
file_date_updated: 2021-11-17T13:47:24Z
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- url: http://users.sussex.ac.uk/~nq28/viktoriia/Thesis_Sharmanska.pdf
month: '04'
oa: 1
oa_version: Published Version
page: '144'
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '5806'
status: public
supervisor:
- first_name: Christoph
  full_name: Lampert, Christoph
  id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
  last_name: Lampert
  orcid: 0000-0001-8622-7887
title: 'Learning with attributes for object recognition: Parametric and non-parametrics
  views'
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2015'
...
---
_id: '1792'
abstract:
- lang: eng
  text: Motivated by recent ideas of Harman (Unif. Distrib. Theory, 2010) we develop
    a new concept of variation of multivariate functions on a compact Hausdorff space
    with respect to a collection D of subsets. We prove a general version of the Koksma-Hlawka
    theorem that holds for this notion of variation and discrepancy with respect to
    D. As special cases, we obtain Koksma-Hlawka inequalities for classical notions,
    such as extreme or isotropic discrepancy. For extreme discrepancy, our result
    coincides with the usual Koksma-Hlawka theorem. We show that the space of functions
    of bounded D-variation contains important discontinuous functions and is closed
    under natural algebraic operations. Finally, we illustrate the results on concrete
    integration problems from integral geometry and stereology.
acknowledgement: F.P. is supported by the Graduate School of IST Austria, A.M.S is
  supported by the Centre for Stochastic Geometry and Advanced Bioimaging funded by
  a grant from the Villum Foundation.
article_processing_charge: No
author:
- first_name: Florian
  full_name: Pausinger, Florian
  id: 2A77D7A2-F248-11E8-B48F-1D18A9856A87
  last_name: Pausinger
  orcid: 0000-0002-8379-3768
- first_name: Anne
  full_name: Svane, Anne
  last_name: Svane
citation:
  ama: Pausinger F, Svane A. A Koksma-Hlawka inequality for general discrepancy systems.
    <i>Journal of Complexity</i>. 2015;31(6):773-797. doi:<a href="https://doi.org/10.1016/j.jco.2015.06.002">10.1016/j.jco.2015.06.002</a>
  apa: Pausinger, F., &#38; Svane, A. (2015). A Koksma-Hlawka inequality for general
    discrepancy systems. <i>Journal of Complexity</i>. Academic Press. <a href="https://doi.org/10.1016/j.jco.2015.06.002">https://doi.org/10.1016/j.jco.2015.06.002</a>
  chicago: Pausinger, Florian, and Anne Svane. “A Koksma-Hlawka Inequality for General
    Discrepancy Systems.” <i>Journal of Complexity</i>. Academic Press, 2015. <a href="https://doi.org/10.1016/j.jco.2015.06.002">https://doi.org/10.1016/j.jco.2015.06.002</a>.
  ieee: F. Pausinger and A. Svane, “A Koksma-Hlawka inequality for general discrepancy
    systems,” <i>Journal of Complexity</i>, vol. 31, no. 6. Academic Press, pp. 773–797,
    2015.
  ista: Pausinger F, Svane A. 2015. A Koksma-Hlawka inequality for general discrepancy
    systems. Journal of Complexity. 31(6), 773–797.
  mla: Pausinger, Florian, and Anne Svane. “A Koksma-Hlawka Inequality for General
    Discrepancy Systems.” <i>Journal of Complexity</i>, vol. 31, no. 6, Academic Press,
    2015, pp. 773–97, doi:<a href="https://doi.org/10.1016/j.jco.2015.06.002">10.1016/j.jco.2015.06.002</a>.
  short: F. Pausinger, A. Svane, Journal of Complexity 31 (2015) 773–797.
corr_author: '1'
date_created: 2018-12-11T11:54:02Z
date_published: 2015-12-01T00:00:00Z
date_updated: 2026-04-09T14:26:05Z
day: '01'
department:
- _id: HeEd
doi: 10.1016/j.jco.2015.06.002
external_id:
  isi:
  - '000362926900001'
intvolume: '        31'
isi: 1
issue: '6'
language:
- iso: eng
month: '12'
oa_version: None
page: 773 - 797
publication: Journal of Complexity
publication_status: published
publisher: Academic Press
publist_id: '5320'
quality_controlled: '1'
related_material:
  record:
  - id: '1399'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: A Koksma-Hlawka inequality for general discrepancy systems
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 31
year: '2015'
...
---
_id: '1709'
abstract:
- lang: eng
  text: The competition for resources among cells, individuals or species is a fundamental
    characteristic of evolution. Biological all-pay auctions have been used to model
    situations where multiple individuals compete for a single resource. However,
    in many situations multiple resources with various values exist and single reward
    auctions are not applicable. We generalize the model to multiple rewards and study
    the evolution of strategies. In biological all-pay auctions the bid of an individual
    corresponds to its strategy and is equivalent to its payment in the auction. The
    decreasingly ordered rewards are distributed according to the decreasingly ordered
    bids of the participating individuals. The reproductive success of an individual
    is proportional to its fitness given by the sum of the rewards won minus its payments.
    Hence, successful bidding strategies spread in the population. We find that the
    results for the multiple reward case are very different from the single reward
    case. While the mixed strategy equilibrium in the single reward case with more
    than two players consists of mostly low-bidding individuals, we show that the
    equilibrium can convert to many high-bidding individuals and a few low-bidding
    individuals in the multiple reward case. Some reward values lead to a specialization
    among the individuals where one subpopulation competes for the rewards and the
    other subpopulation largely avoids costly competitions. Whether the mixed strategy
    equilibrium is an evolutionarily stable strategy (ESS) depends on the specific
    values of the rewards.
acknowledgement: 'This work was supported by grants from the John Templeton Foundation,
  ERC Start Grant (279307: Graph Games), FWF NFN Grant (No S11407N23 RiSE/SHiNE),
  FWF Grant (No P23499N23) and a Microsoft faculty fellows award.'
article_processing_charge: No
article_type: original
author:
- first_name: Johannes
  full_name: Reiter, Johannes
  id: 4A918E98-F248-11E8-B48F-1D18A9856A87
  last_name: Reiter
  orcid: 0000-0002-0170-7353
- first_name: Ayush
  full_name: Kanodia, Ayush
  last_name: Kanodia
- first_name: Raghav
  full_name: Gupta, Raghav
  last_name: Gupta
- first_name: Martin
  full_name: Nowak, Martin
  last_name: Nowak
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
citation:
  ama: Reiter J, Kanodia A, Gupta R, Nowak M, Chatterjee K. Biological auctions with
    multiple rewards. <i>Proceedings of the Royal Society of London Series B Biological
    Sciences</i>. 2015;282(1812). doi:<a href="https://doi.org/10.1098/rspb.2015.1041">10.1098/rspb.2015.1041</a>
  apa: Reiter, J., Kanodia, A., Gupta, R., Nowak, M., &#38; Chatterjee, K. (2015).
    Biological auctions with multiple rewards. <i>Proceedings of the Royal Society
    of London Series B Biological Sciences</i>. Royal Society. <a href="https://doi.org/10.1098/rspb.2015.1041">https://doi.org/10.1098/rspb.2015.1041</a>
  chicago: Reiter, Johannes, Ayush Kanodia, Raghav Gupta, Martin Nowak, and Krishnendu
    Chatterjee. “Biological Auctions with Multiple Rewards.” <i>Proceedings of the
    Royal Society of London Series B Biological Sciences</i>. Royal Society, 2015.
    <a href="https://doi.org/10.1098/rspb.2015.1041">https://doi.org/10.1098/rspb.2015.1041</a>.
  ieee: J. Reiter, A. Kanodia, R. Gupta, M. Nowak, and K. Chatterjee, “Biological
    auctions with multiple rewards,” <i>Proceedings of the Royal Society of London
    Series B Biological Sciences</i>, vol. 282, no. 1812. Royal Society, 2015.
  ista: Reiter J, Kanodia A, Gupta R, Nowak M, Chatterjee K. 2015. Biological auctions
    with multiple rewards. Proceedings of the Royal Society of London Series B Biological
    Sciences. 282(1812).
  mla: Reiter, Johannes, et al. “Biological Auctions with Multiple Rewards.” <i>Proceedings
    of the Royal Society of London Series B Biological Sciences</i>, vol. 282, no.
    1812, Royal Society, 2015, doi:<a href="https://doi.org/10.1098/rspb.2015.1041">10.1098/rspb.2015.1041</a>.
  short: J. Reiter, A. Kanodia, R. Gupta, M. Nowak, K. Chatterjee, Proceedings of
    the Royal Society of London Series B Biological Sciences 282 (2015).
corr_author: '1'
date_created: 2018-12-11T11:53:35Z
date_published: 2015-07-15T00:00:00Z
date_updated: 2026-04-09T14:26:23Z
day: '15'
department:
- _id: KrCh
doi: 10.1098/rspb.2015.1041
external_id:
  isi:
  - '000362305500021'
  pmid:
  - '26180069'
intvolume: '       282'
isi: 1
issue: '1812'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528522/
month: '07'
oa: 1
oa_version: Submitted Version
pmid: 1
project:
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 2584A770-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P 23499-N23
  name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 2587B514-B435-11E9-9278-68D0E5697425
  name: Microsoft Research Faculty Fellowship
publication: Proceedings of the Royal Society of London Series B Biological Sciences
publication_status: published
publisher: Royal Society
publist_id: '5425'
quality_controlled: '1'
related_material:
  record:
  - id: '1400'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Biological auctions with multiple rewards
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 282
year: '2015'
...
---
OA_place: publisher
_id: '1400'
abstract:
- lang: eng
  text: Cancer results from an uncontrolled growth of abnormal cells. Sequentially
    accumulated genetic and epigenetic alterations decrease cell death and increase
    cell replication. We used mathematical models to quantify the effect of driver
    gene mutations. The recently developed targeted therapies can lead to dramatic
    regressions. However, in solid cancers, clinical responses are often short-lived
    because resistant cancer cells evolve. We estimated that approximately 50 different
    mutations can confer resistance to a typical targeted therapeutic agent. We find
    that resistant cells are likely to be present in expanded subclones before the
    start of the treatment. The dominant strategy to prevent the evolution of resistance
    is combination therapy. Our analytical results suggest that in most patients,
    dual therapy, but not monotherapy, can result in long-term disease control. However,
    long-term control can only occur if there are no possible mutations in the genome
    that can cause cross-resistance to both drugs. Furthermore, we showed that simultaneous
    therapy with two drugs is much more likely to result in long-term disease control
    than sequential therapy with the same drugs. To improve our understanding of the
    underlying subclonal evolution we reconstruct the evolutionary history of a patient's
    cancer from next-generation sequencing data of spatially-distinct DNA samples.
    Using a quantitative measure of genetic relatedness, we found that pancreatic
    cancers and their metastases demonstrated a higher level of relatedness than that
    expected for any two cells randomly taken from a normal tissue. This minimal amount
    of genetic divergence among advanced lesions indicates that genetic heterogeneity,
    when quantitatively defined, is not a fundamental feature of the natural history
    of untreated pancreatic cancers. Our newly developed, phylogenomic tool Treeomics
    finds evidence for seeding patterns of metastases and can directly be used to
    discover rules governing the evolution of solid malignancies to transform cancer
    into a more predictable disease.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Johannes
  full_name: Reiter, Johannes
  id: 4A918E98-F248-11E8-B48F-1D18A9856A87
  last_name: Reiter
  orcid: 0000-0002-0170-7353
citation:
  ama: Reiter J. The subclonal evolution of cancer. 2015.
  apa: Reiter, J. (2015). <i>The subclonal evolution of cancer</i>. Institute of Science
    and Technology Austria.
  chicago: Reiter, Johannes. “The Subclonal Evolution of Cancer.” Institute of Science
    and Technology Austria, 2015.
  ieee: J. Reiter, “The subclonal evolution of cancer,” Institute of Science and Technology
    Austria, 2015.
  ista: Reiter J. 2015. The subclonal evolution of cancer. Institute of Science and
    Technology Austria.
  mla: Reiter, Johannes. <i>The Subclonal Evolution of Cancer</i>. Institute of Science
    and Technology Austria, 2015.
  short: J. Reiter, The Subclonal Evolution of Cancer, Institute of Science and Technology
    Austria, 2015.
corr_author: '1'
date_created: 2018-12-11T11:51:48Z
date_published: 2015-04-01T00:00:00Z
date_updated: 2026-04-09T14:26:24Z
day: '01'
degree_awarded: PhD
department:
- _id: KrCh
language:
- iso: eng
month: '04'
oa_version: None
page: '183'
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '5807'
related_material:
  record:
  - id: '2000'
    relation: part_of_dissertation
    status: public
  - id: '1709'
    relation: part_of_dissertation
    status: public
  - id: '2858'
    relation: part_of_dissertation
    status: public
  - id: '2816'
    relation: part_of_dissertation
    status: public
  - id: '2247'
    relation: part_of_dissertation
    status: public
  - id: '3260'
    relation: part_of_dissertation
    status: public
  - id: '3157'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
title: The subclonal evolution of cancer
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2015'
...
---
_id: '1502'
abstract:
- lang: eng
  text: We extend the theory of input-output conformance with operators for merge
    and quotient. The former is useful when testing against multiple requirements
    or views. The latter can be used to generate tests for patches of an already tested
    system. Both operators can combine systems with different action alphabets, which
    is usually the case when constructing complex systems and specifications from
    parts, for instance different views as well as newly defined functionality of
    a~previous version of the system.
acknowledgement: "This research was funded in part by the European Research Council
  (ERC) under grant agreement 267989 (QUAREM), by the Austrian Science Fund (FWF)
  projects S11402-N23(RiSE) and Z211-N23 (Wittgestein Award), by People Programme
  (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013)
  under REA grant agreement 291734, and by the ARTEMIS JU under grant agreement 295373
  (nSafeCer).  Jan Křetínský has been partially supported by the Czech Science Foundation,
  grant No.  P202/12/G061.  Nikola Beneš has been supported by the\r\nMEYS project
  No. CZ.1.07/2.3.00/30.0009 Employment of Newly Graduated Doctors of Science for
  Scientific Excellence."
alternative_title:
- 'Proceedings of the 18th International ACM SIGSOFT Symposium on Component-Based
  Software Engineering '
article_processing_charge: No
author:
- first_name: Nikola
  full_name: Beneš, Nikola
  last_name: Beneš
- first_name: Przemyslaw
  full_name: Daca, Przemyslaw
  id: 49351290-F248-11E8-B48F-1D18A9856A87
  last_name: Daca
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Jan
  full_name: Kretinsky, Jan
  id: 44CEF464-F248-11E8-B48F-1D18A9856A87
  last_name: Kretinsky
  orcid: 0000-0002-8122-2881
- first_name: Dejan
  full_name: Nickovic, Dejan
  last_name: Nickovic
citation:
  ama: 'Beneš N, Daca P, Henzinger TA, Kretinsky J, Nickovic D. Complete composition
    operators for IOCO-testing theory. In: ACM; 2015:101-110. doi:<a href="https://doi.org/10.1145/2737166.2737175">10.1145/2737166.2737175</a>'
  apa: 'Beneš, N., Daca, P., Henzinger, T. A., Kretinsky, J., &#38; Nickovic, D. (2015).
    Complete composition operators for IOCO-testing theory (pp. 101–110). Presented
    at the CBSE: Component-Based Software Engineering , Montreal, QC, Canada: ACM.
    <a href="https://doi.org/10.1145/2737166.2737175">https://doi.org/10.1145/2737166.2737175</a>'
  chicago: Beneš, Nikola, Przemyslaw Daca, Thomas A Henzinger, Jan Kretinsky, and
    Dejan Nickovic. “Complete Composition Operators for IOCO-Testing Theory,” 101–10.
    ACM, 2015. <a href="https://doi.org/10.1145/2737166.2737175">https://doi.org/10.1145/2737166.2737175</a>.
  ieee: 'N. Beneš, P. Daca, T. A. Henzinger, J. Kretinsky, and D. Nickovic, “Complete
    composition operators for IOCO-testing theory,” presented at the CBSE: Component-Based
    Software Engineering , Montreal, QC, Canada, 2015, pp. 101–110.'
  ista: 'Beneš N, Daca P, Henzinger TA, Kretinsky J, Nickovic D. 2015. Complete composition
    operators for IOCO-testing theory. CBSE: Component-Based Software Engineering
    , Proceedings of the 18th International ACM SIGSOFT Symposium on Component-Based
    Software Engineering , , 101–110.'
  mla: Beneš, Nikola, et al. <i>Complete Composition Operators for IOCO-Testing Theory</i>.
    ACM, 2015, pp. 101–10, doi:<a href="https://doi.org/10.1145/2737166.2737175">10.1145/2737166.2737175</a>.
  short: N. Beneš, P. Daca, T.A. Henzinger, J. Kretinsky, D. Nickovic, in:, ACM, 2015,
    pp. 101–110.
conference:
  end_date: 2015-05-08
  location: Montreal, QC, Canada
  name: 'CBSE: Component-Based Software Engineering '
  start_date: 2015-05-04
date_created: 2018-12-11T11:52:24Z
date_published: 2015-05-01T00:00:00Z
date_updated: 2026-04-15T10:02:12Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
- _id: KrCh
doi: 10.1145/2737166.2737175
ec_funded: 1
external_id:
  isi:
  - '000380554800013'
file:
- access_level: open_access
  checksum: c6ce681035c163a158751f240cb7d389
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:17:46Z
  date_updated: 2020-07-14T12:44:59Z
  file_id: '5303'
  file_name: IST-2016-625-v1+1_conf-cbse-BenesDHKN15.pdf
  file_size: 467561
  relation: main_file
file_date_updated: 2020-07-14T12:44:59Z
has_accepted_license: '1'
isi: 1
language:
- iso: eng
month: '05'
oa: 1
oa_version: Submitted Version
page: 101 - 110
project:
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '267989'
  name: Quantitative Reactive Modeling
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z211
  name: Formal methods for the design and analysis of complex systems
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication_identifier:
  isbn:
  - 978-1-4503-3471-6
publication_status: published
publisher: ACM
publist_id: '5676'
pubrep_id: '625'
quality_controlled: '1'
related_material:
  record:
  - id: '1155'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Complete composition operators for IOCO-testing theory
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
year: '2015'
...
---
_id: '1501'
abstract:
- lang: eng
  text: 'We consider Markov decision processes (MDPs) which are a standard model for
    probabilistic systems. We focus on qualitative properties for MDPs that can express
    that desired behaviors of the system arise almost-surely (with probability 1)
    or with positive probability. We introduce a new simulation relation to capture
    the refinement relation of MDPs with respect to qualitative properties, and present
    discrete graph algorithms with quadratic complexity to compute the simulation
    relation. We present an automated technique for assume-guarantee style reasoning
    for compositional analysis of two-player games by giving a counterexample guided
    abstraction-refinement approach to compute our new simulation relation. We show
    a tight link between two-player games and MDPs, and as a consequence the results
    for games are lifted to MDPs with qualitative properties. We have implemented
    our algorithms and show that the compositional analysis leads to significant improvements. '
acknowledgement: 'The research was partly supported by Austrian Science Fund (FWF)
  Grant No. P23499- N23, FWF NFN Grant No. S11407-N23, FWF Grant S11403-N23 (RiSE),
  and FWF Grant Z211-N23 (Wittgenstein Award), ERC Start Grant (279307: Graph Games),
  Microsoft faculty fellows award, the ERC Advanced Grant QUAREM (Quantitative Reactive
  Modeling).'
article_processing_charge: No
arxiv: 1
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Martin
  full_name: Chmelik, Martin
  id: 3624234E-F248-11E8-B48F-1D18A9856A87
  last_name: Chmelik
- first_name: Przemyslaw
  full_name: Daca, Przemyslaw
  id: 49351290-F248-11E8-B48F-1D18A9856A87
  last_name: Daca
citation:
  ama: Chatterjee K, Chmelik M, Daca P. CEGAR for compositional analysis of qualitative
    properties in Markov decision processes. <i>Formal Methods in System Design</i>.
    2015;47(2):230-264. doi:<a href="https://doi.org/10.1007/s10703-015-0235-2">10.1007/s10703-015-0235-2</a>
  apa: Chatterjee, K., Chmelik, M., &#38; Daca, P. (2015). CEGAR for compositional
    analysis of qualitative properties in Markov decision processes. <i>Formal Methods
    in System Design</i>. Springer. <a href="https://doi.org/10.1007/s10703-015-0235-2">https://doi.org/10.1007/s10703-015-0235-2</a>
  chicago: Chatterjee, Krishnendu, Martin Chmelik, and Przemyslaw Daca. “CEGAR for
    Compositional Analysis of Qualitative Properties in Markov Decision Processes.”
    <i>Formal Methods in System Design</i>. Springer, 2015. <a href="https://doi.org/10.1007/s10703-015-0235-2">https://doi.org/10.1007/s10703-015-0235-2</a>.
  ieee: K. Chatterjee, M. Chmelik, and P. Daca, “CEGAR for compositional analysis
    of qualitative properties in Markov decision processes,” <i>Formal Methods in
    System Design</i>, vol. 47, no. 2. Springer, pp. 230–264, 2015.
  ista: Chatterjee K, Chmelik M, Daca P. 2015. CEGAR for compositional analysis of
    qualitative properties in Markov decision processes. Formal Methods in System
    Design. 47(2), 230–264.
  mla: Chatterjee, Krishnendu, et al. “CEGAR for Compositional Analysis of Qualitative
    Properties in Markov Decision Processes.” <i>Formal Methods in System Design</i>,
    vol. 47, no. 2, Springer, 2015, pp. 230–64, doi:<a href="https://doi.org/10.1007/s10703-015-0235-2">10.1007/s10703-015-0235-2</a>.
  short: K. Chatterjee, M. Chmelik, P. Daca, Formal Methods in System Design 47 (2015)
    230–264.
corr_author: '1'
date_created: 2018-12-11T11:52:23Z
date_published: 2015-10-01T00:00:00Z
date_updated: 2026-04-15T10:02:12Z
day: '01'
department:
- _id: KrCh
- _id: ToHe
doi: 10.1007/s10703-015-0235-2
ec_funded: 1
external_id:
  arxiv:
  - '1405.0835'
  isi:
  - '000361752300003'
intvolume: '        47'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1405.0835
month: '10'
oa: 1
oa_version: Preprint
page: 230 - 264
project:
- _id: 2584A770-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P 23499-N23
  name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2587B514-B435-11E9-9278-68D0E5697425
  name: Microsoft Research Faculty Fellowship
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '267989'
  name: Quantitative Reactive Modeling
publication: Formal Methods in System Design
publication_status: published
publisher: Springer
publist_id: '5677'
quality_controlled: '1'
related_material:
  record:
  - id: '1155'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: CEGAR for compositional analysis of qualitative properties in Markov decision
  processes
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 47
year: '2015'
...
---
OA_place: publisher
_id: '1399'
abstract:
- lang: eng
  text: This thesis is concerned with the computation and approximation of intrinsic
    volumes. Given a smooth body M and a certain digital approximation of it, we develop
    algorithms to approximate various intrinsic volumes of M using only measurements
    taken from its digital approximations. The crucial idea behind our novel algorithms
    is to link the recent theory of persistent homology to the theory of intrinsic
    volumes via the Crofton formula from integral geometry and, in particular, via
    Euler characteristic computations. Our main contributions are a multigrid convergent
    digital algorithm to compute the first intrinsic volume of a solid body in R^n
    as well as an appropriate integration pipeline to approximate integral-geometric
    integrals defined over the Grassmannian manifold.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Florian
  full_name: Pausinger, Florian
  id: 2A77D7A2-F248-11E8-B48F-1D18A9856A87
  last_name: Pausinger
  orcid: 0000-0002-8379-3768
citation:
  ama: Pausinger F. On the approximation of intrinsic volumes. 2015.
  apa: Pausinger, F. (2015). <i>On the approximation of intrinsic volumes</i>. Institute
    of Science and Technology Austria.
  chicago: Pausinger, Florian. “On the Approximation of Intrinsic Volumes.” Institute
    of Science and Technology Austria, 2015.
  ieee: F. Pausinger, “On the approximation of intrinsic volumes,” Institute of Science
    and Technology Austria, 2015.
  ista: Pausinger F. 2015. On the approximation of intrinsic volumes. Institute of
    Science and Technology Austria.
  mla: Pausinger, Florian. <i>On the Approximation of Intrinsic Volumes</i>. Institute
    of Science and Technology Austria, 2015.
  short: F. Pausinger, On the Approximation of Intrinsic Volumes, Institute of Science
    and Technology Austria, 2015.
corr_author: '1'
date_created: 2018-12-11T11:51:48Z
date_published: 2015-06-01T00:00:00Z
date_updated: 2026-04-16T10:09:04Z
day: '01'
degree_awarded: PhD
department:
- _id: HeEd
language:
- iso: eng
month: '06'
oa_version: None
page: '144'
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '5808'
related_material:
  record:
  - id: '1662'
    relation: part_of_dissertation
    status: public
  - id: '1792'
    relation: part_of_dissertation
    status: public
  - id: '2255'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
title: On the approximation of intrinsic volumes
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2015'
...
---
OA_place: publisher
OA_type: gold
_id: '1525'
abstract:
- lang: eng
  text: 'Based on 16 recommendations, efforts should be made to achieve the following
    goal: By 2025, all scholarly publication activity in Austria should be Open Access.
    In other words, the final versions of all scholarly publications resulting from
    the support of public resources must be freely accessible on the Internet without
    delay (Gold Open Access). The resources required to meet this obligation shall
    be provided to the authors, or the cost of the publication venues shall be borne
    directly by the research organisations.'
article_processing_charge: No
article_type: original
author:
- first_name: Bruno
  full_name: Bauer, Bruno
  last_name: Bauer
- first_name: Guido
  full_name: Blechl, Guido
  last_name: Blechl
- first_name: Christoph
  full_name: Bock, Christoph
  last_name: Bock
- first_name: Patrick
  full_name: Danowski, Patrick
  id: 2EBD1598-F248-11E8-B48F-1D18A9856A87
  last_name: Danowski
  orcid: 0000-0002-6026-4409
- first_name: Andreas
  full_name: Ferus, Andreas
  last_name: Ferus
- first_name: Anton
  full_name: Graschopf, Anton
  last_name: Graschopf
- first_name: Thomas
  full_name: König, Thomas
  last_name: König
- first_name: Katja
  full_name: Mayer, Katja
  last_name: Mayer
- first_name: Falk
  full_name: Reckling, Falk
  last_name: Reckling
- first_name: Katharina
  full_name: Rieck, Katharina
  last_name: Rieck
- first_name: Peter
  full_name: Seitz, Peter
  last_name: Seitz
- first_name: Herwig
  full_name: Stöger, Herwig
  last_name: Stöger
- first_name: Elvira
  full_name: Welzig, Elvira
  last_name: Welzig
citation:
  ama: Bauer B, Blechl G, Bock C, et al. Arbeitsgruppe „Nationale Strategie“ des Open
    Access Network Austria OANA. <i>VÖB Mitteilungen</i>. 2015;68(3):580-607. doi:<a
    href="https://doi.org/10.5281/zenodo.33178">10.5281/zenodo.33178</a>
  apa: Bauer, B., Blechl, G., Bock, C., Danowski, P., Ferus, A., Graschopf, A., …
    Welzig, E. (2015). Arbeitsgruppe „Nationale Strategie“ des Open Access Network
    Austria OANA. <i>VÖB Mitteilungen</i>. Verein Österreichischer Bibliothekare.
    <a href="https://doi.org/10.5281/zenodo.33178">https://doi.org/10.5281/zenodo.33178</a>
  chicago: Bauer, Bruno, Guido Blechl, Christoph Bock, Patrick Danowski, Andreas Ferus,
    Anton Graschopf, Thomas König, et al. “Arbeitsgruppe „Nationale Strategie“ Des
    Open Access Network Austria OANA.” <i>VÖB Mitteilungen</i>. Verein Österreichischer
    Bibliothekare, 2015. <a href="https://doi.org/10.5281/zenodo.33178">https://doi.org/10.5281/zenodo.33178</a>.
  ieee: B. Bauer <i>et al.</i>, “Arbeitsgruppe „Nationale Strategie“ des Open Access
    Network Austria OANA,” <i>VÖB Mitteilungen</i>, vol. 68, no. 3. Verein Österreichischer
    Bibliothekare, pp. 580–607, 2015.
  ista: Bauer B, Blechl G, Bock C, Danowski P, Ferus A, Graschopf A, König T, Mayer
    K, Reckling F, Rieck K, Seitz P, Stöger H, Welzig E. 2015. Arbeitsgruppe „Nationale
    Strategie“ des Open Access Network Austria OANA. VÖB Mitteilungen. 68(3), 580–607.
  mla: Bauer, Bruno, et al. “Arbeitsgruppe „Nationale Strategie“ Des Open Access Network
    Austria OANA.” <i>VÖB Mitteilungen</i>, vol. 68, no. 3, Verein Österreichischer
    Bibliothekare, 2015, pp. 580–607, doi:<a href="https://doi.org/10.5281/zenodo.33178">10.5281/zenodo.33178</a>.
  short: B. Bauer, G. Blechl, C. Bock, P. Danowski, A. Ferus, A. Graschopf, T. König,
    K. Mayer, F. Reckling, K. Rieck, P. Seitz, H. Stöger, E. Welzig, VÖB Mitteilungen
    68 (2015) 580–607.
date_created: 2018-12-11T11:52:31Z
date_published: 2015-11-12T00:00:00Z
date_updated: 2026-04-29T05:58:40Z
day: '12'
ddc:
- '020'
department:
- _id: E-Lib
doi: 10.5281/zenodo.33178
file:
- access_level: open_access
  checksum: a495fe253bbc7615b1d60e9e85c94408
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:17:59Z
  date_updated: 2020-07-14T12:45:00Z
  file_id: '5317'
  file_name: IST-2016-720-v1+1_OANA_OA-Empfehlungen_12-11-2015.pdf
  file_size: 931707
  relation: main_file
file_date_updated: 2020-07-14T12:45:00Z
has_accepted_license: '1'
intvolume: '        68'
issue: '3'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 580 - 607
publication: VÖB Mitteilungen
publication_status: published
publisher: Verein Österreichischer Bibliothekare
publist_id: '5648'
pubrep_id: '720'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Arbeitsgruppe „Nationale Strategie“ des Open Access Network Austria OANA
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 68
year: '2015'
...
---
_id: '9719'
abstract:
- lang: eng
  text: Parasitism creates selection for resistance mechanisms in host populations
    and is hypothesized to promote increased host evolvability. However, the influence
    of these traits on host evolution when parasites are no longer present is unclear.
    We used experimental evolution and whole-genome sequencing of Escherichia coli
    to determine the effects of past and present exposure to parasitic viruses (phages)
    on the spread of mutator alleles, resistance, and bacterial competitive fitness.
    We found that mutator alleles spread rapidly during adaptation to any of four
    different phage species, and this pattern was even more pronounced with multiple
    phages present simultaneously. However, hypermutability did not detectably accelerate
    adaptation in the absence of phages and recovery of fitness costs associated with
    resistance. Several lineages evolved phage resistance through elevated mucoidy,
    and during subsequent evolution in phage-free conditions they rapidly reverted
    to nonmucoid, phage-susceptible phenotypes. Genome sequencing revealed that this
    phenotypic reversion was achieved by additional genetic changes rather than by
    genotypic reversion of the initial resistance mutations. Insertion sequence (IS)
    elements played a key role in both the acquisition of resistance and adaptation
    in the absence of parasites; unlike single nucleotide polymorphisms, IS insertions
    were not more frequent in mutator lineages. Our results provide a genetic explanation
    for rapid reversion of mucoidy, a phenotype observed in other bacterial species
    including human pathogens. Moreover, this demonstrates that the types of genetic
    change underlying adaptation to fitness costs, and consequently the impact of
    evolvability mechanisms such as increased point-mutation rates, depend critically
    on the mechanism of resistance.
article_processing_charge: No
author:
- first_name: Sébastien
  full_name: Wielgoss, Sébastien
  last_name: Wielgoss
- first_name: Tobias
  full_name: Bergmiller, Tobias
  id: 2C471CFA-F248-11E8-B48F-1D18A9856A87
  last_name: Bergmiller
  orcid: 0000-0001-5396-4346
- first_name: Anna M.
  full_name: Bischofberger, Anna M.
  last_name: Bischofberger
- first_name: Alex R.
  full_name: Hall, Alex R.
  last_name: Hall
citation:
  ama: 'Wielgoss S, Bergmiller T, Bischofberger AM, Hall AR. Data from: Adaptation
    to parasites and costs of parasite resistance in mutator and non-mutator bacteria.
    2015. doi:<a href="https://doi.org/10.5061/dryad.cj910">10.5061/dryad.cj910</a>'
  apa: 'Wielgoss, S., Bergmiller, T., Bischofberger, A. M., &#38; Hall, A. R. (2015).
    Data from: Adaptation to parasites and costs of parasite resistance in mutator
    and non-mutator bacteria. Dryad. <a href="https://doi.org/10.5061/dryad.cj910">https://doi.org/10.5061/dryad.cj910</a>'
  chicago: 'Wielgoss, Sébastien, Tobias Bergmiller, Anna M. Bischofberger, and Alex
    R. Hall. “Data from: Adaptation to Parasites and Costs of Parasite Resistance
    in Mutator and Non-Mutator Bacteria.” Dryad, 2015. <a href="https://doi.org/10.5061/dryad.cj910">https://doi.org/10.5061/dryad.cj910</a>.'
  ieee: 'S. Wielgoss, T. Bergmiller, A. M. Bischofberger, and A. R. Hall, “Data from:
    Adaptation to parasites and costs of parasite resistance in mutator and non-mutator
    bacteria.” Dryad, 2015.'
  ista: 'Wielgoss S, Bergmiller T, Bischofberger AM, Hall AR. 2015. Data from: Adaptation
    to parasites and costs of parasite resistance in mutator and non-mutator bacteria,
    Dryad, <a href="https://doi.org/10.5061/dryad.cj910">10.5061/dryad.cj910</a>.'
  mla: 'Wielgoss, Sébastien, et al. <i>Data from: Adaptation to Parasites and Costs
    of Parasite Resistance in Mutator and Non-Mutator Bacteria</i>. Dryad, 2015, doi:<a
    href="https://doi.org/10.5061/dryad.cj910">10.5061/dryad.cj910</a>.'
  short: S. Wielgoss, T. Bergmiller, A.M. Bischofberger, A.R. Hall, (2015).
date_created: 2021-07-26T08:44:04Z
date_published: 2015-12-21T00:00:00Z
date_updated: 2026-04-29T05:57:01Z
day: '21'
department:
- _id: CaGu
doi: 10.5061/dryad.cj910
main_file_link:
- open_access: '1'
  url: https://doi.org/10.5061/dryad.cj910
month: '12'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
  record:
  - id: '5749'
    relation: used_in_publication
    status: public
status: public
title: 'Data from: Adaptation to parasites and costs of parasite resistance in mutator
  and non-mutator bacteria'
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2015'
...
---
OA_place: repository
OA_type: green
_id: '1610'
abstract:
- lang: eng
  text: The edit distance between two words w1, w2 is the minimal number of word operations
    (letter insertions, deletions, and substitutions) necessary to transform w1 to
    w2. The edit distance generalizes to languages L1,L2, where the edit distance
    is the minimal number k such that for every word from L1 there exists a word in
    L2 with edit distance at most k. We study the edit distance computation problem
    between pushdown automata and their subclasses. The problem of computing edit
    distance to pushdown automata is undecidable, and in practice, the interesting
    question is to compute the edit distance from a pushdown automaton (the implementation,
    a standard model for programs with recursion) to a regular language (the specification).
    In this work, we present a complete picture of decidability and complexity for
    deciding whether, for a given threshold k, the edit distance from a pushdown automaton
    to a finite automaton is at most k.
acknowledgement: "This research was funded in part by the European Research Council
  (ERC) under\r\ngrant agreement 267989 (QUAREM), by the Austrian Science Fund (FWF)
  projects\r\nS11402-N23 (RiSE) and Z211-N23 (Wittgenstein Award), FWF Grant No P23499-\r\nN23,
  FWF NFN Grant No S11407-N23 (RiSE), ERC Start grant (279307: Graph\r\nGames), and
  MSR faculty fellows award."
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Rasmus
  full_name: Ibsen-Jensen, Rasmus
  id: 3B699956-F248-11E8-B48F-1D18A9856A87
  last_name: Ibsen-Jensen
  orcid: 0000-0003-4783-0389
- first_name: Jan
  full_name: Otop, Jan
  id: 2FC5DA74-F248-11E8-B48F-1D18A9856A87
  last_name: Otop
citation:
  ama: 'Chatterjee K, Henzinger TA, Ibsen-Jensen R, Otop J. Edit distance for pushdown
    automata. In: <i>42nd International Colloquium on Automata, Languages, and Programming</i>.
    Vol 9135. Springer Nature; 2015:121-133. doi:<a href="https://doi.org/10.1007/978-3-662-47666-6_10">10.1007/978-3-662-47666-6_10</a>'
  apa: 'Chatterjee, K., Henzinger, T. A., Ibsen-Jensen, R., &#38; Otop, J. (2015).
    Edit distance for pushdown automata. In <i>42nd International Colloquium on Automata,
    Languages, and Programming</i> (Vol. 9135, pp. 121–133). Kyoto, Japan: Springer
    Nature. <a href="https://doi.org/10.1007/978-3-662-47666-6_10">https://doi.org/10.1007/978-3-662-47666-6_10</a>'
  chicago: Chatterjee, Krishnendu, Thomas A Henzinger, Rasmus Ibsen-Jensen, and Jan
    Otop. “Edit Distance for Pushdown Automata.” In <i>42nd International Colloquium
    on Automata, Languages, and Programming</i>, 9135:121–33. Springer Nature, 2015.
    <a href="https://doi.org/10.1007/978-3-662-47666-6_10">https://doi.org/10.1007/978-3-662-47666-6_10</a>.
  ieee: K. Chatterjee, T. A. Henzinger, R. Ibsen-Jensen, and J. Otop, “Edit distance
    for pushdown automata,” in <i>42nd International Colloquium on Automata, Languages,
    and Programming</i>, Kyoto, Japan, 2015, vol. 9135, no. Part II, pp. 121–133.
  ista: 'Chatterjee K, Henzinger TA, Ibsen-Jensen R, Otop J. 2015. Edit distance for
    pushdown automata. 42nd International Colloquium on Automata, Languages, and Programming.
    ICALP: Automata, Languages and Programming, LNCS, vol. 9135, 121–133.'
  mla: Chatterjee, Krishnendu, et al. “Edit Distance for Pushdown Automata.” <i>42nd
    International Colloquium on Automata, Languages, and Programming</i>, vol. 9135,
    no. Part II, Springer Nature, 2015, pp. 121–33, doi:<a href="https://doi.org/10.1007/978-3-662-47666-6_10">10.1007/978-3-662-47666-6_10</a>.
  short: K. Chatterjee, T.A. Henzinger, R. Ibsen-Jensen, J. Otop, in:, 42nd International
    Colloquium on Automata, Languages, and Programming, Springer Nature, 2015, pp.
    121–133.
conference:
  end_date: 2015-07-10
  location: Kyoto, Japan
  name: 'ICALP: Automata, Languages and Programming'
  start_date: 2015-07-06
date_created: 2018-12-11T11:53:01Z
date_published: 2015-07-01T00:00:00Z
date_updated: 2026-04-29T06:14:48Z
day: '01'
department:
- _id: KrCh
- _id: ToHe
doi: 10.1007/978-3-662-47666-6_10
ec_funded: 1
external_id:
  arxiv:
  - '1504.08259'
  isi:
  - '000364317900010'
intvolume: '      9135'
isi: 1
issue: Part II
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1504.08259
month: '07'
oa: 1
oa_version: Preprint
page: 121 - 133
project:
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '267989'
  name: Quantitative Reactive Modeling
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z211
  name: Formal methods for the design and analysis of complex systems
- _id: 2584A770-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P 23499-N23
  name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S11407
  name: Game Theory
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2587B514-B435-11E9-9278-68D0E5697425
  name: Microsoft Research Faculty Fellowship
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
publication: 42nd International Colloquium on Automata, Languages, and Programming
publication_identifier:
  isbn:
  - 978-3-662-47665-9
publication_status: published
publisher: Springer Nature
publist_id: '5556'
pubrep_id: '321'
quality_controlled: '1'
related_material:
  record:
  - id: '5438'
    relation: earlier_version
    status: public
  - id: '465'
    relation: later_version
    status: public
scopus_import: '1'
status: public
title: Edit distance for pushdown automata
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9135
year: '2015'
...
---
_id: '5438'
abstract:
- lang: eng
  text: "The edit distance between two words w1, w2 is the minimal number of word
    operations (letter insertions, deletions, and substitutions) necessary to transform
    w1 to w2. The edit distance generalizes to languages L1, L2, where the edit distance
    is the minimal number k such that for every word from L1 there exists a word in
    L2 with edit distance at most k. We study the edit distance computation problem
    between pushdown automata and their subclasses.\r\nThe problem of computing edit
    distance to a pushdown automaton is undecidable, and in practice, the interesting
    question is to compute the edit distance from a pushdown automaton (the implementation,
    a standard model for programs with recursion) to a regular language (the specification).
    In this work, we present a complete picture of decidability and complexity for
    deciding whether, for a given threshold k, the edit distance from a pushdown automaton
    to a finite automaton is at most k. "
alternative_title:
- IST Austria Technical Report
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Rasmus
  full_name: Ibsen-Jensen, Rasmus
  id: 3B699956-F248-11E8-B48F-1D18A9856A87
  last_name: Ibsen-Jensen
  orcid: 0000-0003-4783-0389
- first_name: Jan
  full_name: Otop, Jan
  id: 2FC5DA74-F248-11E8-B48F-1D18A9856A87
  last_name: Otop
citation:
  ama: Chatterjee K, Henzinger TA, Ibsen-Jensen R, Otop J. <i>Edit Distance for Pushdown
    Automata</i>. IST Austria; 2015. doi:<a href="https://doi.org/10.15479/AT:IST-2015-334-v1-1">10.15479/AT:IST-2015-334-v1-1</a>
  apa: Chatterjee, K., Henzinger, T. A., Ibsen-Jensen, R., &#38; Otop, J. (2015).
    <i>Edit distance for pushdown automata</i>. IST Austria. <a href="https://doi.org/10.15479/AT:IST-2015-334-v1-1">https://doi.org/10.15479/AT:IST-2015-334-v1-1</a>
  chicago: Chatterjee, Krishnendu, Thomas A Henzinger, Rasmus Ibsen-Jensen, and Jan
    Otop. <i>Edit Distance for Pushdown Automata</i>. IST Austria, 2015. <a href="https://doi.org/10.15479/AT:IST-2015-334-v1-1">https://doi.org/10.15479/AT:IST-2015-334-v1-1</a>.
  ieee: K. Chatterjee, T. A. Henzinger, R. Ibsen-Jensen, and J. Otop, <i>Edit distance
    for pushdown automata</i>. IST Austria, 2015.
  ista: Chatterjee K, Henzinger TA, Ibsen-Jensen R, Otop J. 2015. Edit distance for
    pushdown automata, IST Austria, 15p.
  mla: Chatterjee, Krishnendu, et al. <i>Edit Distance for Pushdown Automata</i>.
    IST Austria, 2015, doi:<a href="https://doi.org/10.15479/AT:IST-2015-334-v1-1">10.15479/AT:IST-2015-334-v1-1</a>.
  short: K. Chatterjee, T.A. Henzinger, R. Ibsen-Jensen, J. Otop, Edit Distance for
    Pushdown Automata, IST Austria, 2015.
date_created: 2018-12-12T11:39:20Z
date_published: 2015-05-05T00:00:00Z
date_updated: 2026-04-29T06:14:48Z
day: '05'
ddc:
- '004'
department:
- _id: KrCh
doi: 10.15479/AT:IST-2015-334-v1-1
file:
- access_level: open_access
  checksum: 8a5f2d77560e552af87eb1982437a43b
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T11:53:56Z
  date_updated: 2020-07-14T12:46:55Z
  file_id: '5518'
  file_name: IST-2015-334-v1+1_report.pdf
  file_size: 422573
  relation: main_file
file_date_updated: 2020-07-14T12:46:55Z
has_accepted_license: '1'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: '15'
publication_identifier:
  issn:
  - 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '334'
related_material:
  record:
  - id: '465'
    relation: later_version
    status: public
  - id: '1610'
    relation: later_version
    status: public
status: public
title: Edit distance for pushdown automata
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '1619'
abstract:
- lang: eng
  text: The emergence of drug resistant pathogens is a serious public health problem.
    It is a long-standing goal to predict rates of resistance evolution and design
    optimal treatment strategies accordingly. To this end, it is crucial to reveal
    the underlying causes of drug-specific differences in the evolutionary dynamics
    leading to resistance. However, it remains largely unknown why the rates of resistance
    evolution via spontaneous mutations and the diversity of mutational paths vary
    substantially between drugs. Here we comprehensively quantify the distribution
    of fitness effects (DFE) of mutations, a key determinant of evolutionary dynamics,
    in the presence of eight antibiotics representing the main modes of action. Using
    precise high-throughput fitness measurements for genome-wide Escherichia coli
    gene deletion strains, we find that the width of the DFE varies dramatically between
    antibiotics and, contrary to conventional wisdom, for some drugs the DFE width
    is lower than in the absence of stress. We show that this previously underappreciated
    divergence in DFE width among antibiotics is largely caused by their distinct
    drug-specific dose-response characteristics. Unlike the DFE, the magnitude of
    the changes in tolerated drug concentration resulting from genome-wide mutations
    is similar for most drugs but exceptionally small for the antibiotic nitrofurantoin,
    i.e., mutations generally have considerably smaller resistance effects for nitrofurantoin
    than for other drugs. A population genetics model predicts that resistance evolution
    for drugs with this property is severely limited and confined to reproducible
    mutational paths. We tested this prediction in laboratory evolution experiments
    using the “morbidostat”, a device for evolving bacteria in well-controlled drug
    environments. Nitrofurantoin resistance indeed evolved extremely slowly via reproducible
    mutations—an almost paradoxical behavior since this drug causes DNA damage and
    increases the mutation rate. Overall, we identified novel quantitative characteristics
    of the evolutionary landscape that provide the conceptual foundation for predicting
    the dynamics of drug resistance evolution.
article_number: e1002299
article_processing_charge: No
author:
- first_name: Guillaume
  full_name: Chevereau, Guillaume
  id: 424D78A0-F248-11E8-B48F-1D18A9856A87
  last_name: Chevereau
- first_name: Marta
  full_name: Dravecka, Marta
  id: 4342E402-F248-11E8-B48F-1D18A9856A87
  last_name: Dravecka
  orcid: 0000-0002-2519-8004
- first_name: Tugce
  full_name: Batur, Tugce
  last_name: Batur
- first_name: Aysegul
  full_name: Guvenek, Aysegul
  last_name: Guvenek
- first_name: Dilay
  full_name: Ayhan, Dilay
  last_name: Ayhan
- first_name: Erdal
  full_name: Toprak, Erdal
  last_name: Toprak
- first_name: Mark Tobias
  full_name: Bollenbach, Mark Tobias
  id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
  last_name: Bollenbach
  orcid: 0000-0003-4398-476X
citation:
  ama: Chevereau G, Lukacisinova M, Batur T, et al. Quantifying the determinants of
    evolutionary dynamics leading to drug resistance. <i>PLoS Biology</i>. 2015;13(11).
    doi:<a href="https://doi.org/10.1371/journal.pbio.1002299">10.1371/journal.pbio.1002299</a>
  apa: Chevereau, G., Lukacisinova, M., Batur, T., Guvenek, A., Ayhan, D., Toprak,
    E., &#38; Bollenbach, M. T. (2015). Quantifying the determinants of evolutionary
    dynamics leading to drug resistance. <i>PLoS Biology</i>. Public Library of Science.
    <a href="https://doi.org/10.1371/journal.pbio.1002299">https://doi.org/10.1371/journal.pbio.1002299</a>
  chicago: Chevereau, Guillaume, Marta Lukacisinova, Tugce Batur, Aysegul Guvenek,
    Dilay Ayhan, Erdal Toprak, and Mark Tobias Bollenbach. “Quantifying the Determinants
    of Evolutionary Dynamics Leading to Drug Resistance.” <i>PLoS Biology</i>. Public
    Library of Science, 2015. <a href="https://doi.org/10.1371/journal.pbio.1002299">https://doi.org/10.1371/journal.pbio.1002299</a>.
  ieee: G. Chevereau <i>et al.</i>, “Quantifying the determinants of evolutionary
    dynamics leading to drug resistance,” <i>PLoS Biology</i>, vol. 13, no. 11. Public
    Library of Science, 2015.
  ista: Chevereau G, Lukacisinova M, Batur T, Guvenek A, Ayhan D, Toprak E, Bollenbach
    MT. 2015. Quantifying the determinants of evolutionary dynamics leading to drug
    resistance. PLoS Biology. 13(11), e1002299.
  mla: Chevereau, Guillaume, et al. “Quantifying the Determinants of Evolutionary
    Dynamics Leading to Drug Resistance.” <i>PLoS Biology</i>, vol. 13, no. 11, e1002299,
    Public Library of Science, 2015, doi:<a href="https://doi.org/10.1371/journal.pbio.1002299">10.1371/journal.pbio.1002299</a>.
  short: G. Chevereau, M. Lukacisinova, T. Batur, A. Guvenek, D. Ayhan, E. Toprak,
    M.T. Bollenbach, PLoS Biology 13 (2015).
corr_author: '1'
date_created: 2018-12-11T11:53:04Z
date_published: 2015-11-18T00:00:00Z
date_updated: 2026-05-04T22:30:54Z
day: '18'
ddc:
- '570'
department:
- _id: ToBo
doi: 10.1371/journal.pbio.1002299
ec_funded: 1
external_id:
  isi:
  - '000365898900011'
file:
- access_level: open_access
  checksum: 0e82e3279f50b15c6c170c042627802b
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:09:00Z
  date_updated: 2020-07-14T12:45:07Z
  file_id: '4723'
  file_name: IST-2016-468-v1+1_journal.pbio.1002299.pdf
  file_size: 1387760
  relation: main_file
file_date_updated: 2020-07-14T12:45:07Z
has_accepted_license: '1'
intvolume: '        13'
isi: 1
issue: '11'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 25EB3A80-B435-11E9-9278-68D0E5697425
  grant_number: RGP0042/2013
  name: Revealing the fundamental limits of cell growth
- _id: 25E9AF9E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P27201-B22
  name: Revealing the mechanisms underlying drug interactions
- _id: 25E83C2C-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '303507'
  name: Optimality principles in responses to antibiotics
publication: PLoS Biology
publication_status: published
publisher: Public Library of Science
publist_id: '5547'
pubrep_id: '468'
quality_controlled: '1'
related_material:
  record:
  - id: '9711'
    relation: research_data
    status: public
  - id: '9765'
    relation: research_data
    status: public
  - id: '6263'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Quantifying the determinants of evolutionary dynamics leading to drug resistance
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 13
year: '2015'
...
---
_id: '11582'
abstract:
- lang: eng
  text: We have observed a sample of typical z ∼ 1 star-forming galaxies, selected
    from the HiZELS survey, with the new K-band Multi-Object Spectrograph (KMOS) near-infrared,
    multi-integral field unit instrument on the Very Large Telescope (VLT), in order
    to obtain their dynamics and metallicity gradients. The majority of our galaxies
    have a metallicity gradient consistent with being flat or negative (i.e. higher
    metallicity cores than outskirts). Intriguingly, we find a trend between metallicity
    gradient and specific star formation rate (sSFR), such that galaxies with a high
    sSFR tend to have relatively metal poor centres, a result which is strengthened
    when combined with data sets from the literature. This result appears to explain
    the discrepancies reported between different high-redshift studies and varying
    claims for evolution. From a galaxy evolution perspective, the trend we see would
    mean that a galaxy's sSFR is governed by the amount of metal-poor gas that can
    be funnelled into its core, triggered either by merging or through efficient accretion.
    In fact, merging may play a significant role as it is the starburst galaxies at
    all epochs, which have the more positive metallicity gradients. Our results may
    help to explain the origin of the fundamental metallicity relation, in which galaxies
    at a fixed mass are observed to have lower metallicities at higher star formation
    rates, especially if the metallicity is measured in an aperture encompassing only
    the central regions of the galaxy. Finally, we note that this study demonstrates
    the power of KMOS as an efficient instrument for large-scale resolved galaxy surveys.
acknowledgement: First, we acknowledge the referee for their comments, which have
  improved the clarity of this paper. JPS and IRS acknowledge support from STFC (ST/I001573/1).
  IRS also acknowledges support from the ERC Advanced Investigator programme DUSTYGAL
  and a Royal Society/Wolfson Merit Award. DS acknowledges financial support from
  NWO through a Veni fellowship and from FCT through the award of an FCT-IF starting
  grant. PNB acknowledges STFC for financial support.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: John P.
  full_name: Stott, John P.
  last_name: Stott
- first_name: David
  full_name: Sobral, David
  last_name: Sobral
- first_name: A. M.
  full_name: Swinbank, A. M.
  last_name: Swinbank
- first_name: Ian
  full_name: Smail, Ian
  last_name: Smail
- first_name: Richard
  full_name: Bower, Richard
  last_name: Bower
- first_name: Philip N.
  full_name: Best, Philip N.
  last_name: Best
- first_name: Ray M.
  full_name: Sharples, Ray M.
  last_name: Sharples
- first_name: James E.
  full_name: Geach, James E.
  last_name: Geach
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
citation:
  ama: Stott JP, Sobral D, Swinbank AM, et al. A relationship between specific star
    formation rate and metallicity gradient within z ∼ 1 galaxies from KMOS-HiZELS.
    <i>Monthly Notices of the Royal Astronomical Society</i>. 2014;443(3):2695-2704.
    doi:<a href="https://doi.org/10.1093/mnras/stu1343">10.1093/mnras/stu1343</a>
  apa: Stott, J. P., Sobral, D., Swinbank, A. M., Smail, I., Bower, R., Best, P. N.,
    … Matthee, J. J. (2014). A relationship between specific star formation rate and
    metallicity gradient within z ∼ 1 galaxies from KMOS-HiZELS. <i>Monthly Notices
    of the Royal Astronomical Society</i>. Oxford University Press. <a href="https://doi.org/10.1093/mnras/stu1343">https://doi.org/10.1093/mnras/stu1343</a>
  chicago: Stott, John P., David Sobral, A. M. Swinbank, Ian Smail, Richard Bower,
    Philip N. Best, Ray M. Sharples, James E. Geach, and Jorryt J Matthee. “A Relationship
    between Specific Star Formation Rate and Metallicity Gradient within z ∼ 1 Galaxies
    from KMOS-HiZELS.” <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford
    University Press, 2014. <a href="https://doi.org/10.1093/mnras/stu1343">https://doi.org/10.1093/mnras/stu1343</a>.
  ieee: J. P. Stott <i>et al.</i>, “A relationship between specific star formation
    rate and metallicity gradient within z ∼ 1 galaxies from KMOS-HiZELS,” <i>Monthly
    Notices of the Royal Astronomical Society</i>, vol. 443, no. 3. Oxford University
    Press, pp. 2695–2704, 2014.
  ista: Stott JP, Sobral D, Swinbank AM, Smail I, Bower R, Best PN, Sharples RM, Geach
    JE, Matthee JJ. 2014. A relationship between specific star formation rate and
    metallicity gradient within z ∼ 1 galaxies from KMOS-HiZELS. Monthly Notices of
    the Royal Astronomical Society. 443(3), 2695–2704.
  mla: Stott, John P., et al. “A Relationship between Specific Star Formation Rate
    and Metallicity Gradient within z ∼ 1 Galaxies from KMOS-HiZELS.” <i>Monthly Notices
    of the Royal Astronomical Society</i>, vol. 443, no. 3, Oxford University Press,
    2014, pp. 2695–704, doi:<a href="https://doi.org/10.1093/mnras/stu1343">10.1093/mnras/stu1343</a>.
  short: J.P. Stott, D. Sobral, A.M. Swinbank, I. Smail, R. Bower, P.N. Best, R.M.
    Sharples, J.E. Geach, J.J. Matthee, Monthly Notices of the Royal Astronomical
    Society 443 (2014) 2695–2704.
date_created: 2022-07-14T12:16:10Z
date_published: 2014-09-21T00:00:00Z
date_updated: 2022-08-19T08:27:25Z
day: '21'
doi: 10.1093/mnras/stu1343
extern: '1'
external_id:
  arxiv:
  - '1407.1047'
intvolume: '       443'
issue: '3'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: abundances'
- 'galaxies: evolution'
- 'galaxies: kinematics and dynamics'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1407.1047
month: '09'
oa: 1
oa_version: Preprint
page: 2695-2704
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
  eissn:
  - 1365-2966
  issn:
  - 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: A relationship between specific star formation rate and metallicity gradient
  within z ∼ 1 galaxies from KMOS-HiZELS
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 443
year: '2014'
...
---
_id: '11583'
abstract:
- lang: eng
  text: 'Candidate galaxies at redshifts of z ∼ 10 are now being found in extremely
    deep surveys, probing very small areas. As a consequence, candidates are very
    faint, making spectroscopic confirmation practically impossible. In order to overcome
    such limitations, we have undertaken the CF-HiZELS survey, which is a large-area,
    medium-depth near-infrared narrow-band survey targeted at z = 8.8 Lyman α (Lyα)
    emitters (LAEs) and covering 10 deg2 in part of the SSA22 field with the Canada–France–Hawaii
    Telescope (CFHT). We surveyed a comoving volume of 4.7 × 106 Mpc3 to a Lyα luminosity
    limit of 6.3 × 1043舁erg舁s−1. We look for Lyα candidates by applying the following
    criteria: (i) clear emission-line source, (ii) no optical detections (ugriz from
    CFHTLS), (iii) no visible detection in the optical stack (ugriz > 27), (iv) visually
    checked reliable NBJ and J detections and (v) J − K ≤ 0. We compute photometric
    redshifts and remove a significant amount of dusty lower redshift line-emitters
    at z ∼ 1.4 or 2.2. A total of 13 Lyα candidates were found, of which two are marked
    as strong candidates, but the majority have very weak constraints on their spectral
    energy distributions. Using follow-up observations with SINFONI/VLT, we are able
    to exclude the most robust candidates as LAEs. We put a strong constraint on the
    Lyα luminosity function at z ∼ 9 and make realistic predictions for ongoing and
    future surveys. Our results show that surveys for the highest redshift LAEs are
    susceptible of multiple contaminations and that spectroscopic follow-up is absolutely
    necessary.'
acknowledgement: We thank the anonymous referee for the comments and suggestions which
  improved both the quality and clarity of this work. DS acknowledges financial support
  from the Netherlands Organisation for Scientific Research (NWO) through a Veni fellowship.
  IRS acknowledges support from STFC (ST/I001573/1), a Leverhulme Fellowship, the
  ERC Advanced Investigator programme DUSTYGAL 321334 and a Royal Society/Wolfson
  Merit Award. PNB acknowledges support from the Leverhulme Trust. JWK acknowledges
  the support from the Creative Research Initiative Program, no. 2008- 0060544, of
  the National Research Foundation of Korea (NRF) funded by the Korean government
  (MSIP). JPUF and BMJ acknowledge support from the ERC-StG grant EGGS-278202. The
  Dark Cosmology Centre is funded by the Danish National Research Foundation. This
  work is based in part on data obtained as part of the UKIRT Infrared Deep Sky Survey.
  Based on observations obtained with MegaPrime/MegaCam, a joint project of CFHT and
  CEA/IRFU, at the Canada–France–Hawaii Telescope (CFHT) which is operated by the
  National Research Council (NRC) of Canada, the Institut National des Science de
  l’Univers of the Centre National de la Recherche Scientifique (CNRS) of France and
  the University of Hawaii. This work is based in part on data products produced at
  Terapix available at the Canadian Astronomy Data Centre as part of the Canada-France-Hawaii
  Telescope Legacy Survey, a collaborative project of NRC and CNRS. This work was
  only possible due to OPTICON/FP7 and the access that it granted to the CFHT telescope.
  The authors also wish to acknowledge the CFHTLS and UKIDSS surveys for their excellent
  legacy and complementary value – without such high-quality data sets, this research
  would not have been possible.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
- first_name: David
  full_name: Sobral, David
  last_name: Sobral
- first_name: A. M.
  full_name: Swinbank, A. M.
  last_name: Swinbank
- first_name: Ian
  full_name: Smail, Ian
  last_name: Smail
- first_name: P. N.
  full_name: Best, P. N.
  last_name: Best
- first_name: Jae-Woo
  full_name: Kim, Jae-Woo
  last_name: Kim
- first_name: Marijn
  full_name: Franx, Marijn
  last_name: Franx
- first_name: Bo
  full_name: Milvang-Jensen, Bo
  last_name: Milvang-Jensen
- first_name: Johan
  full_name: Fynbo, Johan
  last_name: Fynbo
citation:
  ama: 'Matthee JJ, Sobral D, Swinbank AM, et al. A 10 deg2 Lyman α survey at z=8.8
    with spectroscopic follow-up: Strong constraints on the luminosity function and
    implications for other surveys. <i>Monthly Notices of the Royal Astronomical Society</i>.
    2014;440(3):2375-2387. doi:<a href="https://doi.org/10.1093/mnras/stu392">10.1093/mnras/stu392</a>'
  apa: 'Matthee, J. J., Sobral, D., Swinbank, A. M., Smail, I., Best, P. N., Kim,
    J.-W., … Fynbo, J. (2014). A 10 deg2 Lyman α survey at z=8.8 with spectroscopic
    follow-up: Strong constraints on the luminosity function and implications for
    other surveys. <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford
    University Press. <a href="https://doi.org/10.1093/mnras/stu392">https://doi.org/10.1093/mnras/stu392</a>'
  chicago: 'Matthee, Jorryt J, David Sobral, A. M. Swinbank, Ian Smail, P. N. Best,
    Jae-Woo Kim, Marijn Franx, Bo Milvang-Jensen, and Johan Fynbo. “A 10 Deg2 Lyman
    α Survey at Z=8.8 with Spectroscopic Follow-up: Strong Constraints on the Luminosity
    Function and Implications for Other Surveys.” <i>Monthly Notices of the Royal
    Astronomical Society</i>. Oxford University Press, 2014. <a href="https://doi.org/10.1093/mnras/stu392">https://doi.org/10.1093/mnras/stu392</a>.'
  ieee: 'J. J. Matthee <i>et al.</i>, “A 10 deg2 Lyman α survey at z=8.8 with spectroscopic
    follow-up: Strong constraints on the luminosity function and implications for
    other surveys,” <i>Monthly Notices of the Royal Astronomical Society</i>, vol.
    440, no. 3. Oxford University Press, pp. 2375–2387, 2014.'
  ista: 'Matthee JJ, Sobral D, Swinbank AM, Smail I, Best PN, Kim J-W, Franx M, Milvang-Jensen
    B, Fynbo J. 2014. A 10 deg2 Lyman α survey at z=8.8 with spectroscopic follow-up:
    Strong constraints on the luminosity function and implications for other surveys.
    Monthly Notices of the Royal Astronomical Society. 440(3), 2375–2387.'
  mla: 'Matthee, Jorryt J., et al. “A 10 Deg2 Lyman α Survey at Z=8.8 with Spectroscopic
    Follow-up: Strong Constraints on the Luminosity Function and Implications for
    Other Surveys.” <i>Monthly Notices of the Royal Astronomical Society</i>, vol.
    440, no. 3, Oxford University Press, 2014, pp. 2375–87, doi:<a href="https://doi.org/10.1093/mnras/stu392">10.1093/mnras/stu392</a>.'
  short: J.J. Matthee, D. Sobral, A.M. Swinbank, I. Smail, P.N. Best, J.-W. Kim, M.
    Franx, B. Milvang-Jensen, J. Fynbo, Monthly Notices of the Royal Astronomical
    Society 440 (2014) 2375–2387.
date_created: 2022-07-14T12:33:24Z
date_published: 2014-05-21T00:00:00Z
date_updated: 2024-10-14T11:37:28Z
day: '21'
doi: 10.1093/mnras/stu392
extern: '1'
external_id:
  arxiv:
  - '1402.6697'
intvolume: '       440'
issue: '3'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: evolution'
- 'galaxies: high-redshift'
- 'cosmology: observations'
- dark ages
- reionization
- first stars
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1402.6697
month: '05'
oa: 1
oa_version: Preprint
page: 2375-2387
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
  eissn:
  - 1365-2966
  issn:
  - 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'A 10 deg2 Lyman α survey at z=8.8 with spectroscopic follow-up: Strong constraints
  on the luminosity function and implications for other surveys'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 440
year: '2014'
...
---
_id: '11750'
abstract:
- lang: eng
  text: We report on the magnetic properties of a hot-pressed FeSb 2 sample. We find
    a significant increase in the magnetic susceptibility in our sample when compared
    with the values previously reported for the polycrystalline sample. The pronounced
    Curie tail at low temperature corresponds to 0.2% of Fe 2+ impurities per mole.
    In the intrinsic conductivity region, the susceptibility due to free carriers
    shows thermally activated behavior and is consistent with the data reported for
    single crystal FeSb 2 . Based on our data and analysis, while the enhanced magnetic
    susceptibility in our sample comes mainly from a small amount of unreacted Fe,
    the contribution from the enhanced carrier density due to lattice and strain defects
    arising from the ball milling process is also significant. Existence of an unreacted
    Fe phase is evidenced by small coercivity values of ~100 observed at 50 and 300
    K.
article_number: '6675864'
article_processing_charge: No
article_type: original
author:
- first_name: Mani
  full_name: Pokharel, Mani
  last_name: Pokharel
- first_name: Huaizhou
  full_name: Zhao, Huaizhou
  last_name: Zhao
- first_name: Kimberly A
  full_name: Modic, Kimberly A
  id: 13C26AC0-EB69-11E9-87C6-5F3BE6697425
  last_name: Modic
  orcid: 0000-0001-9760-3147
- first_name: Zhifeng
  full_name: Ren, Zhifeng
  last_name: Ren
- first_name: Cyril
  full_name: Opeil, Cyril
  last_name: Opeil
citation:
  ama: Pokharel M, Zhao H, Modic KA, Ren Z, Opeil C. Magnetic properties of hot-pressed
    FeSb2. <i>IEEE Transactions on Magnetics</i>. 2014;50(5). doi:<a href="https://doi.org/10.1109/TMAG.2013.2292607">10.1109/TMAG.2013.2292607</a>
  apa: Pokharel, M., Zhao, H., Modic, K. A., Ren, Z., &#38; Opeil, C. (2014). Magnetic
    properties of hot-pressed FeSb2. <i>IEEE Transactions on Magnetics</i>. Institute
    of Electrical and Electronics Engineers. <a href="https://doi.org/10.1109/TMAG.2013.2292607">https://doi.org/10.1109/TMAG.2013.2292607</a>
  chicago: Pokharel, Mani, Huaizhou Zhao, Kimberly A Modic, Zhifeng Ren, and Cyril
    Opeil. “Magnetic Properties of Hot-Pressed FeSb2.” <i>IEEE Transactions on Magnetics</i>.
    Institute of Electrical and Electronics Engineers, 2014. <a href="https://doi.org/10.1109/TMAG.2013.2292607">https://doi.org/10.1109/TMAG.2013.2292607</a>.
  ieee: M. Pokharel, H. Zhao, K. A. Modic, Z. Ren, and C. Opeil, “Magnetic properties
    of hot-pressed FeSb2,” <i>IEEE Transactions on Magnetics</i>, vol. 50, no. 5.
    Institute of Electrical and Electronics Engineers, 2014.
  ista: Pokharel M, Zhao H, Modic KA, Ren Z, Opeil C. 2014. Magnetic properties of
    hot-pressed FeSb2. IEEE Transactions on Magnetics. 50(5), 6675864.
  mla: Pokharel, Mani, et al. “Magnetic Properties of Hot-Pressed FeSb2.” <i>IEEE
    Transactions on Magnetics</i>, vol. 50, no. 5, 6675864, Institute of Electrical
    and Electronics Engineers, 2014, doi:<a href="https://doi.org/10.1109/TMAG.2013.2292607">10.1109/TMAG.2013.2292607</a>.
  short: M. Pokharel, H. Zhao, K.A. Modic, Z. Ren, C. Opeil, IEEE Transactions on
    Magnetics 50 (2014).
date_created: 2022-08-08T08:26:02Z
date_published: 2014-05-01T00:00:00Z
date_updated: 2022-08-11T09:51:22Z
day: '01'
doi: 10.1109/TMAG.2013.2292607
extern: '1'
intvolume: '        50'
issue: '5'
language:
- iso: eng
month: '05'
oa_version: None
publication: IEEE Transactions on Magnetics
publication_identifier:
  eissn:
  - 1941-0069
  issn:
  - 0018-9464
publication_status: published
publisher: Institute of Electrical and Electronics Engineers
quality_controlled: '1'
scopus_import: '1'
status: public
title: Magnetic properties of hot-pressed FeSb2
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 50
year: '2014'
...
---
_id: '11789'
abstract:
- lang: eng
  text: "We study a weighted online bipartite matching problem: G(V 1, V 2, E) is
    a weighted bipartite graph where V 1 is known beforehand and the vertices of V
    2 arrive online. The goal is to match vertices of V 2 as they arrive to vertices
    in V 1, so as to maximize the sum of weights of edges in the matching. If assignments
    to V 1 cannot be changed, no bounded competitive ratio is achievable. We study
    the weighted online matching problem with free disposal, where vertices in V 1
    can be assigned multiple times, but only get credit for the maximum weight edge
    assigned to them over the course of the algorithm. For this problem, the greedy
    algorithm is 0.5-competitive and determining whether a better competitive ratio
    is achievable is a well known open problem.\r\n\r\nWe identify an interesting
    special case where the edge weights are decomposable as the product of two factors,
    one corresponding to each end point of the edge. This is analogous to the well
    studied related machines model in the scheduling literature, although the objective
    functions are different. For this case of decomposable edge weights, we design
    a 0.5664 competitive randomized algorithm in complete bipartite graphs. We show
    that such instances with decomposable weights are non-trivial by establishing
    upper bounds of 0.618 for deterministic and 0.8 for randomized algorithms.\r\n\r\nA
    tight competitive ratio of 1 − 1/e ≈ 0.632 was known previously for both the 0-1
    case as well as the case where edge weights depend on the offline vertices only,
    but for these cases, reassignments cannot change the quality of the solution.
    Beating 0.5 for weighted matching where reassignments are necessary has been a
    significant challenge. We thus give the first online algorithm with competitive
    ratio strictly better than 0.5 for a non-trivial case of weighted matching with
    free disposal."
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Moses
  full_name: Charikar, Moses
  last_name: Charikar
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
- first_name: Huy L.
  full_name: Nguyễn, Huy L.
  last_name: Nguyễn
citation:
  ama: 'Charikar M, Henzinger M, Nguyễn HL. Online bipartite matching with decomposable
    weights. In: <i>22nd Annual European Symposium on Algorithms</i>. Vol 8737. Springer
    Nature; 2014:260-271. doi:<a href="https://doi.org/10.1007/978-3-662-44777-2_22">10.1007/978-3-662-44777-2_22</a>'
  apa: 'Charikar, M., Henzinger, M., &#38; Nguyễn, H. L. (2014). Online bipartite
    matching with decomposable weights. In <i>22nd Annual European Symposium on Algorithms</i>
    (Vol. 8737, pp. 260–271). Wroclaw, Poland: Springer Nature. <a href="https://doi.org/10.1007/978-3-662-44777-2_22">https://doi.org/10.1007/978-3-662-44777-2_22</a>'
  chicago: Charikar, Moses, Monika Henzinger, and Huy L. Nguyễn. “Online Bipartite
    Matching with Decomposable Weights.” In <i>22nd Annual European Symposium on Algorithms</i>,
    8737:260–71. Springer Nature, 2014. <a href="https://doi.org/10.1007/978-3-662-44777-2_22">https://doi.org/10.1007/978-3-662-44777-2_22</a>.
  ieee: M. Charikar, M. Henzinger, and H. L. Nguyễn, “Online bipartite matching with
    decomposable weights,” in <i>22nd Annual European Symposium on Algorithms</i>,
    Wroclaw, Poland, 2014, vol. 8737, pp. 260–271.
  ista: 'Charikar M, Henzinger M, Nguyễn HL. 2014. Online bipartite matching with
    decomposable weights. 22nd Annual European Symposium on Algorithms. ESA: Annual
    European Symposium on Algorithms, LNCS, vol. 8737, 260–271.'
  mla: Charikar, Moses, et al. “Online Bipartite Matching with Decomposable Weights.”
    <i>22nd Annual European Symposium on Algorithms</i>, vol. 8737, Springer Nature,
    2014, pp. 260–71, doi:<a href="https://doi.org/10.1007/978-3-662-44777-2_22">10.1007/978-3-662-44777-2_22</a>.
  short: M. Charikar, M. Henzinger, H.L. Nguyễn, in:, 22nd Annual European Symposium
    on Algorithms, Springer Nature, 2014, pp. 260–271.
conference:
  end_date: 2014-09-10
  location: Wroclaw, Poland
  name: 'ESA: Annual European Symposium on Algorithms'
  start_date: 2014-09-08
date_created: 2022-08-11T10:41:47Z
date_published: 2014-09-01T00:00:00Z
date_updated: 2024-11-06T12:11:36Z
day: '01'
doi: 10.1007/978-3-662-44777-2_22
extern: '1'
external_id:
  arxiv:
  - '1409.2139'
intvolume: '      8737'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1409.2139
month: '09'
oa: 1
oa_version: Preprint
page: 260 - 271
publication: 22nd Annual European Symposium on Algorithms
publication_identifier:
  isbn:
  - 978-366244776-5
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Online bipartite matching with decomposable weights
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8737
year: '2014'
...
---
_id: '11790'
abstract:
- lang: eng
  text: "Assume a seller wants to sell a digital product in a social network where
    a buyer’s valuation of the item has positive network externalities from her neighbors
    that already have the item. The goal of the seller is to maximize his revenue.
    Previous work on this problem [7] studies the case where clients are offered the
    item in sequence and have to pay personalized prices. This is highly infeasible
    in large scale networks such as the Facebook graph: (1) Offering items to the
    clients one after the other consumes a large amount of time, and (2) price-discrimination
    of clients could appear unfair to them and result in negative client reaction
    or could conflict with legal requirements.\r\n\r\nWe study a setting dealing with
    these issues. Specifically, the item is offered in parallel to multiple clients
    at the same time and at the same price. This is called a round. We show that with
    O(logn) rounds, where n is the number of clients, a constant factor of the revenue
    with price discrimination can be achieved and that this is not possible with o(logn)
    rounds. Moreover we show that it is APX-hard to maximize the revenue and we give
    constant factor approximation algorithms for various further settings of limited
    price discrimination."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Luděk
  full_name: Cigler, Luděk
  last_name: Cigler
- first_name: Wolfgang
  full_name: Dvořák, Wolfgang
  last_name: Dvořák
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
- first_name: Martin
  full_name: Starnberger, Martin
  last_name: Starnberger
citation:
  ama: 'Cigler L, Dvořák W, Henzinger M, Starnberger M. Limiting price discrimination
    when selling products with positive network externalities. In: <i>10th International
    Conference of Web and Internet Economics</i>. Vol 8877. Springer Nature; 2014:44-57.
    doi:<a href="https://doi.org/10.1007/978-3-319-13129-0_4">10.1007/978-3-319-13129-0_4</a>'
  apa: 'Cigler, L., Dvořák, W., Henzinger, M., &#38; Starnberger, M. (2014). Limiting
    price discrimination when selling products with positive network externalities.
    In <i>10th International Conference of Web and Internet Economics</i> (Vol. 8877,
    pp. 44–57). Beijing, China: Springer Nature. <a href="https://doi.org/10.1007/978-3-319-13129-0_4">https://doi.org/10.1007/978-3-319-13129-0_4</a>'
  chicago: Cigler, Luděk, Wolfgang Dvořák, Monika Henzinger, and Martin Starnberger.
    “Limiting Price Discrimination When Selling Products with Positive Network Externalities.”
    In <i>10th International Conference of Web and Internet Economics</i>, 8877:44–57.
    Springer Nature, 2014. <a href="https://doi.org/10.1007/978-3-319-13129-0_4">https://doi.org/10.1007/978-3-319-13129-0_4</a>.
  ieee: L. Cigler, W. Dvořák, M. Henzinger, and M. Starnberger, “Limiting price discrimination
    when selling products with positive network externalities,” in <i>10th International
    Conference of Web and Internet Economics</i>, Beijing, China, 2014, vol. 8877,
    pp. 44–57.
  ista: 'Cigler L, Dvořák W, Henzinger M, Starnberger M. 2014. Limiting price discrimination
    when selling products with positive network externalities. 10th International
    Conference of Web and Internet Economics. WINE: International Conference on Web
    and Internet Economics, LNCS, vol. 8877, 44–57.'
  mla: Cigler, Luděk, et al. “Limiting Price Discrimination When Selling Products
    with Positive Network Externalities.” <i>10th International Conference of Web
    and Internet Economics</i>, vol. 8877, Springer Nature, 2014, pp. 44–57, doi:<a
    href="https://doi.org/10.1007/978-3-319-13129-0_4">10.1007/978-3-319-13129-0_4</a>.
  short: L. Cigler, W. Dvořák, M. Henzinger, M. Starnberger, in:, 10th International
    Conference of Web and Internet Economics, Springer Nature, 2014, pp. 44–57.
conference:
  end_date: 2014-12-17
  location: Beijing, China
  name: 'WINE: International Conference on Web and Internet Economics'
  start_date: 2014-12-14
date_created: 2022-08-11T10:58:44Z
date_published: 2014-12-01T00:00:00Z
date_updated: 2024-11-06T12:11:48Z
day: '01'
doi: 10.1007/978-3-319-13129-0_4
extern: '1'
intvolume: '      8877'
language:
- iso: eng
month: '12'
oa_version: None
page: 44 - 57
publication: 10th International Conference of Web and Internet Economics
publication_identifier:
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Limiting price discrimination when selling products with positive network externalities
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8877
year: '2014'
...
---
_id: '118'
abstract:
- lang: eng
  text: While the penetration of objects into granular media is well-studied, there
    is little understanding of how objects settle in gravities, geff, different from
    that of Earth - a scenario potentially relevant to the geomorphology of planets
    and asteroids and also to their exploration using man-made devices. By conducting
    experiments in an accelerating frame, we explore geff ranging from 0.4 g to 1.2
    g. Surprisingly, we find that the rest depth is independent of geff and also that
    the time required for the object to come to rest scales like geff-1/2. With discrete
    element modeling simulations, we reproduce the experimental results and extend
    the range of geff to objects as small as asteroids and as large as Jupiter. Our
    results shed light on the initial stage of sedimentation into dry granular media
    across a range of celestial bodies and also have implications for the design of
    man-made, extraterrestrial vehicles and structures. Key Points The settling depth
    in granular media is independent of gravity The settling time scales like g-1/2
    Layering driven by granular sedimentation should be similar.
acknowledgement: 'The Spanish MINECO project FIS2011-26675, the PIUNA program (U.
  Navarra), and the Project 29942WL (Fonds de Solidarité Prioritaire France-Cuba)
  have partially supported this research. '
author:
- first_name: Ernesto
  full_name: Altshuler, Ernesto
  last_name: Altshuler
- first_name: H
  full_name: Torres, H
  last_name: Torres
- first_name: A
  full_name: González_Pita, A
  last_name: González_Pita
- first_name: Colina G
  full_name: Sánchez, Colina G
  last_name: Sánchez
- first_name: Carlos
  full_name: Pérez Penichet, Carlos
  last_name: Pérez Penichet
- first_name: Scott R
  full_name: Waitukaitis, Scott R
  id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87
  last_name: Waitukaitis
  orcid: 0000-0002-2299-3176
- first_name: Rauól
  full_name: Hidalgo, Rauól
  last_name: Hidalgo
citation:
  ama: Altshuler E, Torres H, González_Pita A, et al. Settling into dry granular media
    in different gravities. <i>Geophysical Research Letters</i>. 2014;41(9):3032-3037.
    doi:<a href="https://doi.org/10.1002/2014GL059229">10.1002/2014GL059229</a>
  apa: Altshuler, E., Torres, H., González_Pita, A., Sánchez, C. G., Pérez Penichet,
    C., Waitukaitis, S. R., &#38; Hidalgo, R. (2014). Settling into dry granular media
    in different gravities. <i>Geophysical Research Letters</i>. Wiley-Blackwell.
    <a href="https://doi.org/10.1002/2014GL059229">https://doi.org/10.1002/2014GL059229</a>
  chicago: Altshuler, Ernesto, H Torres, A González_Pita, Colina G Sánchez, Carlos
    Pérez Penichet, Scott R Waitukaitis, and Rauól Hidalgo. “Settling into Dry Granular
    Media in Different Gravities.” <i>Geophysical Research Letters</i>. Wiley-Blackwell,
    2014. <a href="https://doi.org/10.1002/2014GL059229">https://doi.org/10.1002/2014GL059229</a>.
  ieee: E. Altshuler <i>et al.</i>, “Settling into dry granular media in different
    gravities,” <i>Geophysical Research Letters</i>, vol. 41, no. 9. Wiley-Blackwell,
    pp. 3032–3037, 2014.
  ista: Altshuler E, Torres H, González_Pita A, Sánchez CG, Pérez Penichet C, Waitukaitis
    SR, Hidalgo R. 2014. Settling into dry granular media in different gravities.
    Geophysical Research Letters. 41(9), 3032–3037.
  mla: Altshuler, Ernesto, et al. “Settling into Dry Granular Media in Different Gravities.”
    <i>Geophysical Research Letters</i>, vol. 41, no. 9, Wiley-Blackwell, 2014, pp.
    3032–37, doi:<a href="https://doi.org/10.1002/2014GL059229">10.1002/2014GL059229</a>.
  short: E. Altshuler, H. Torres, A. González_Pita, C.G. Sánchez, C. Pérez Penichet,
    S.R. Waitukaitis, R. Hidalgo, Geophysical Research Letters 41 (2014) 3032–3037.
date_created: 2018-12-11T11:44:43Z
date_published: 2014-05-16T00:00:00Z
date_updated: 2021-01-12T06:48:53Z
day: '16'
doi: 10.1002/2014GL059229
extern: '1'
intvolume: '        41'
issue: '9'
language:
- iso: eng
month: '05'
oa_version: None
page: 3032 - 3037
publication: Geophysical Research Letters
publication_status: published
publisher: Wiley-Blackwell
publist_id: '7936'
quality_controlled: '1'
status: public
title: Settling into dry granular media in different gravities
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 41
year: '2014'
...
