---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '19663'
abstract:
- lang: eng
  text: The centrosome is a microtubule orchestrator, nucleating and anchoring microtubules
    that grow radially and exert forces on cargos. At the same time, mechanical stresses
    from the microenvironment and cellular shape changes compress and bend microtubules.
    Yet, centrosomes are membraneless organelles, raising the question of how centrosomes
    withstand mechanical forces. Here, we discover that centrosomes can deform and
    even fracture. We reveal that centrosomes experience deformations during navigational
    pathfinding within motile cells. Coherence of the centrosome is maintained by
    Dyrk3 and cNAP1, preventing fracturing by forces. While cells can compensate for
    the depletion of centriolar-based centrosomes, the fracturing of centrosomes impedes
    cellular function by generating coexisting microtubule organizing centers that
    compete during path navigation and thereby cause cellular entanglement in the
    microenvironment. Our findings show that cells actively maintain the integrity
    of the centrosome to withstand mechanical forces. These results suggest that centrosome
    stability preservation is fundamental, given that almost all cells in multicellular
    organisms experience forces.
acknowledgement: "We thank L. Pelkmans and D. Dormann for providing Dyrk3-EGFP plasmids;
  M. Heuzé for providing a RFP-Pericentrin plasmid; T. Balla for providing a PH-Akt-GFP
  plasmid; E. Snaar-Jagalska for providing a pLenti-V6.3 Ultra-Chili plasmid; T. Tang
  for providing CEP120 a plasmid; D. Trono for providing pMD2.G and psSPAX2 plasmids;
  M. Sixt for providing EB3-mCherry and EMTB-mCherry plasmids as well as 3T3 fibroblasts,
  Lifeact-GFP Hoxb8 cells, and LX293 cells; M. Duggan for RNA isolation from migrating
  DCs; M. Schuster from the Biomedical Sequencing Facility at CeMM; J. Schwarz for
  providing Jurkat T cells; M. Götz for initial transcriptome analysis; M. Götz and
  F. Merino for discussion and sharing reagents; F. Gärtner for discussions and support;
  M. Benjamin Braun for critical reading of the manuscript; and the Core Facility
  Bioimaging, the Core Facility Flow Cytometry, and the Animal Core Facility of the
  Biomedical Center (BMC) for excellent support.\r\nThis work was supported by Peter
  Hans Hofschneider Professorship of the Stiftung Experimentelle Biomedizin (J.R.);
  German Research Foundation grant “CRC914, project A12” (J.R); German Research Foundation
  grant “SPP2332, project 492014049” (J.R.); LMU Institutional Strategy LMU-Excellent
  within the framework of the German Excellence Initiative (J.R.); Medical & Clinician
  Scientist Program (MCSP) LMU Munich (J.K.); Deutsche Forschungsgemeinschaft (DFG;
  German Research Foundation) under Germany’s Excellence Strategy – EXC2151 – 390873048
  (D.B.); Deutsche Forschungsgemeinschaft (DFG; German Research Foundation) Grossgeräteantrag
  457838313 and under Germany’s Excellence Strategy – EXC 2151 – 390873048 (E.K.);
  Ministry of Innovation, Science and Research of North-Rhine-Westphalia (fellowship
  AZ: 421-8.03.03.02-137069) (E.K.); TRA Life and Health (University of Bonn) as part
  of the Excellence Strategy of the federal and state governments (E.K.); and CZI
  grant DAF2020-225401 and grant (DOI https://doi.org/10.37921/120055ratwvi) from
  the Chan Zuckerberg Initiative DAF (R.H.)."
article_number: eadx4047
article_processing_charge: Yes
article_type: original
author:
- first_name: Madeleine T.
  full_name: Schmitt, Madeleine T.
  last_name: Schmitt
- first_name: Janina
  full_name: Kroll, Janina
  last_name: Kroll
- first_name: Mauricio J.A.
  full_name: Ruiz-Fernandez, Mauricio J.A.
  last_name: Ruiz-Fernandez
- first_name: Robert
  full_name: Hauschild, Robert
  id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
  last_name: Hauschild
  orcid: 0000-0001-9843-3522
- first_name: Shaunak
  full_name: Ghosh, Shaunak
  last_name: Ghosh
- first_name: Petra
  full_name: Kameritsch, Petra
  last_name: Kameritsch
- first_name: Jack
  full_name: Merrin, Jack
  id: 4515C308-F248-11E8-B48F-1D18A9856A87
  last_name: Merrin
  orcid: 0000-0001-5145-4609
- first_name: Johanna
  full_name: Schmid, Johanna
  last_name: Schmid
- first_name: Kasia
  full_name: Stefanowski, Kasia
  last_name: Stefanowski
- first_name: Andreas W.
  full_name: Thomae, Andreas W.
  last_name: Thomae
- first_name: Jingyuan
  full_name: Cheng, Jingyuan
  last_name: Cheng
- first_name: Gamze Naz
  full_name: Öztan, Gamze Naz
  last_name: Öztan
- first_name: Peter
  full_name: Konopka, Peter
  last_name: Konopka
- first_name: Germán Camargo
  full_name: Ortega, Germán Camargo
  last_name: Ortega
- first_name: Thomas
  full_name: Penz, Thomas
  last_name: Penz
- first_name: Luisa
  full_name: Bach, Luisa
  last_name: Bach
- first_name: Dirk
  full_name: Baumjohann, Dirk
  last_name: Baumjohann
- first_name: Christoph
  full_name: Bock, Christoph
  last_name: Bock
- first_name: Tobias
  full_name: Straub, Tobias
  last_name: Straub
- first_name: Felix
  full_name: Meissner, Felix
  last_name: Meissner
- first_name: Eva
  full_name: Kiermaier, Eva
  id: 3EB04B78-F248-11E8-B48F-1D18A9856A87
  last_name: Kiermaier
  orcid: 0000-0001-6165-5738
- first_name: Jörg
  full_name: Renkawitz, Jörg
  id: 3F0587C8-F248-11E8-B48F-1D18A9856A87
  last_name: Renkawitz
  orcid: 0000-0003-2856-3369
citation:
  ama: Schmitt MT, Kroll J, Ruiz-Fernandez MJA, et al. Protecting centrosomes from
    fracturing enables efficient cell navigation. <i>Science Advances</i>. 2025;11(17).
    doi:<a href="https://doi.org/10.1126/sciadv.adx4047">10.1126/sciadv.adx4047</a>
  apa: Schmitt, M. T., Kroll, J., Ruiz-Fernandez, M. J. A., Hauschild, R., Ghosh,
    S., Kameritsch, P., … Renkawitz, J. (2025). Protecting centrosomes from fracturing
    enables efficient cell navigation. <i>Science Advances</i>. AAAS. <a href="https://doi.org/10.1126/sciadv.adx4047">https://doi.org/10.1126/sciadv.adx4047</a>
  chicago: Schmitt, Madeleine T., Janina Kroll, Mauricio J.A. Ruiz-Fernandez, Robert
    Hauschild, Shaunak Ghosh, Petra Kameritsch, Jack Merrin, et al. “Protecting Centrosomes
    from Fracturing Enables Efficient Cell Navigation.” <i>Science Advances</i>. AAAS,
    2025. <a href="https://doi.org/10.1126/sciadv.adx4047">https://doi.org/10.1126/sciadv.adx4047</a>.
  ieee: M. T. Schmitt <i>et al.</i>, “Protecting centrosomes from fracturing enables
    efficient cell navigation,” <i>Science Advances</i>, vol. 11, no. 17. AAAS, 2025.
  ista: Schmitt MT, Kroll J, Ruiz-Fernandez MJA, Hauschild R, Ghosh S, Kameritsch
    P, Merrin J, Schmid J, Stefanowski K, Thomae AW, Cheng J, Öztan GN, Konopka P,
    Ortega GC, Penz T, Bach L, Baumjohann D, Bock C, Straub T, Meissner F, Kiermaier
    E, Renkawitz J. 2025. Protecting centrosomes from fracturing enables efficient
    cell navigation. Science Advances. 11(17), eadx4047.
  mla: Schmitt, Madeleine T., et al. “Protecting Centrosomes from Fracturing Enables
    Efficient Cell Navigation.” <i>Science Advances</i>, vol. 11, no. 17, eadx4047,
    AAAS, 2025, doi:<a href="https://doi.org/10.1126/sciadv.adx4047">10.1126/sciadv.adx4047</a>.
  short: M.T. Schmitt, J. Kroll, M.J.A. Ruiz-Fernandez, R. Hauschild, S. Ghosh, P.
    Kameritsch, J. Merrin, J. Schmid, K. Stefanowski, A.W. Thomae, J. Cheng, G.N.
    Öztan, P. Konopka, G.C. Ortega, T. Penz, L. Bach, D. Baumjohann, C. Bock, T. Straub,
    F. Meissner, E. Kiermaier, J. Renkawitz, Science Advances 11 (2025).
date_created: 2025-05-11T22:02:38Z
date_published: 2025-04-25T00:00:00Z
date_updated: 2025-09-30T12:26:21Z
day: '25'
ddc:
- '570'
department:
- _id: Bio
- _id: NanoFab
doi: 10.1126/sciadv.adx4047
external_id:
  isi:
  - '001476113400016'
  pmid:
  - '40279414'
file:
- access_level: open_access
  checksum: e8ba22922fa5b23ccfcce8865f57226c
  content_type: application/pdf
  creator: dernst
  date_created: 2025-05-12T07:46:10Z
  date_updated: 2025-05-12T07:46:10Z
  file_id: '19679'
  file_name: 2025_ScienceAdvance_Schmitt.pdf
  file_size: 2707050
  relation: main_file
  success: 1
file_date_updated: 2025-05-12T07:46:10Z
fulldoi: https://doi.org/10.1126/sciadv.adx4047
has_accepted_license: '1'
intvolume: '        11'
isi: 1
issue: '17'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: c08e9ad1-5a5b-11eb-8a69-9d1cf3b07473
  grant_number: CZI01
  name: Tools for automation and feedback microscopy
publication: Science Advances
publication_identifier:
  eissn:
  - 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: Protecting centrosomes from fracturing enables efficient cell navigation
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 11
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
_id: '19664'
abstract:
- lang: eng
  text: Persistent revivals recently observed in Rydberg atom simulators have challenged
    our understanding of thermalization and attracted much interest to the concept
    of quantum many-body scars (QMBSs). QMBSs are non-thermal highly excited eigenstates
    that coexist with typical eigenstates in the spectrum of many-body Hamiltonians,
    and have since been reported in multiple theoretical models, including the so-called
    PXP model, approximately realized by Rydberg simulators. At the same time, questions
    of how common QMBSs are and in what models they are physically realized remain
    open. In this Letter, we demonstrate that QMBSs exist in a broader family of models
    that includes and generalizes PXP to longer-range constraints and states with
    different periodicity. We show that in each model, multiple QMBS families can
    be found. Each of them relies on a different approximate algebra, leading to oscillatory
    dynamics in all cases. However, in contrast to the PXP model, their observation
    requires launching dynamics from weakly entangled initial states rather than from
    a product state. QMBSs reported here may be experimentally probed using Rydberg
    atom simulator in the regime of longer-range Rydberg blockades.
acknowledgement: The authors are grateful to Zlatko Papić, Dolev Bluvstein, Nishad
  Maskara, Marcello Dalmonte, Thomas Iadecola, and Johannes Feldmeier for insightful
  discussions. A. K., M. L., and M. S. acknowledge support by the European Research
  Council under the European Union’s Horizon 2020 research and innovation program
  (Grant Agreement No. 850899). J.-Y. D. acknowledges funding from the European Union’s
  Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant
  Agreement No. 101034413.
article_number: '160401'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Aron
  full_name: Kerschbaumer, Aron
  id: ade85a9c-3200-11ee-973b-91c1eb240410
  last_name: Kerschbaumer
  orcid: 0009-0002-2370-8661
- first_name: Marko
  full_name: Ljubotina, Marko
  id: F75EE9BE-5C90-11EA-905D-16643DDC885E
  last_name: Ljubotina
  orcid: 0000-0003-0038-7068
- first_name: Maksym
  full_name: Serbyn, Maksym
  id: 47809E7E-F248-11E8-B48F-1D18A9856A87
  last_name: Serbyn
  orcid: 0000-0002-2399-5827
- first_name: Jean-Yves Marc
  full_name: Desaules, Jean-Yves Marc
  id: 6c292945-a610-11ed-9eec-c3be1ad62a80
  last_name: Desaules
  orcid: 0000-0002-3749-6375
citation:
  ama: Kerschbaumer A, Ljubotina M, Serbyn M, Desaules J-YM. Quantum many-body scars
    beyond the PXP model in Rydberg simulators. <i>Physical Review Letters</i>. 2025;134(16).
    doi:<a href="https://doi.org/10.1103/PhysRevLett.134.160401">10.1103/PhysRevLett.134.160401</a>
  apa: Kerschbaumer, A., Ljubotina, M., Serbyn, M., &#38; Desaules, J.-Y. M. (2025).
    Quantum many-body scars beyond the PXP model in Rydberg simulators. <i>Physical
    Review Letters</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevLett.134.160401">https://doi.org/10.1103/PhysRevLett.134.160401</a>
  chicago: Kerschbaumer, Aron, Marko Ljubotina, Maksym Serbyn, and Jean-Yves Marc
    Desaules. “Quantum Many-Body Scars beyond the PXP Model in Rydberg Simulators.”
    <i>Physical Review Letters</i>. American Physical Society, 2025. <a href="https://doi.org/10.1103/PhysRevLett.134.160401">https://doi.org/10.1103/PhysRevLett.134.160401</a>.
  ieee: A. Kerschbaumer, M. Ljubotina, M. Serbyn, and J.-Y. M. Desaules, “Quantum
    many-body scars beyond the PXP model in Rydberg simulators,” <i>Physical Review
    Letters</i>, vol. 134, no. 16. American Physical Society, 2025.
  ista: Kerschbaumer A, Ljubotina M, Serbyn M, Desaules J-YM. 2025. Quantum many-body
    scars beyond the PXP model in Rydberg simulators. Physical Review Letters. 134(16),
    160401.
  mla: Kerschbaumer, Aron, et al. “Quantum Many-Body Scars beyond the PXP Model in
    Rydberg Simulators.” <i>Physical Review Letters</i>, vol. 134, no. 16, 160401,
    American Physical Society, 2025, doi:<a href="https://doi.org/10.1103/PhysRevLett.134.160401">10.1103/PhysRevLett.134.160401</a>.
  short: A. Kerschbaumer, M. Ljubotina, M. Serbyn, J.-Y.M. Desaules, Physical Review
    Letters 134 (2025).
date_created: 2025-05-11T22:02:38Z
date_published: 2025-04-22T00:00:00Z
date_updated: 2026-06-10T08:40:51Z
day: '22'
ddc:
- '530'
department:
- _id: MaSe
doi: 10.1103/PhysRevLett.134.160401
ec_funded: 1
external_id:
  arxiv:
  - '2410.18913'
  isi:
  - '001480669300011'
  pmid:
  - '40344113'
file:
- access_level: open_access
  checksum: b7f581291e20f152d0efc64727314ca2
  content_type: application/pdf
  creator: dernst
  date_created: 2025-05-12T07:33:38Z
  date_updated: 2025-05-12T07:33:38Z
  file_id: '19677'
  file_name: 2025_PhysReviewLetters_Kerschbaumer.pdf
  file_size: 1028993
  relation: main_file
  success: 1
file_date_updated: 2025-05-12T07:33:38Z
fulldoi: https://doi.org/10.1103/PhysRevLett.134.160401
has_accepted_license: '1'
intvolume: '       134'
isi: 1
issue: '16'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
  call_identifier: H2020
  grant_number: '850899'
  name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
publication: Physical Review Letters
publication_identifier:
  eissn:
  - 1079-7114
  issn:
  - 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
  link:
  - description: News on ISTA website
    relation: press_release
    url: https://ista.ac.at/en/news/a-sky-full-of-quantum-scars/
  record:
  - id: '19623'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Quantum many-body scars beyond the PXP model in Rydberg simulators
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 134
year: '2025'
...
---
OA_place: repository
OA_type: green
_id: '19665'
abstract:
- lang: eng
  text: As AI-based decision-makers increasingly influence human lives, it is a growing
    concern that their decisions may be unfair or biased with respect to people's
    protected attributes, such as gender and race. Most existing bias prevention measures
    provide probabilistic fairness guarantees in the long run, and it is possible
    that the decisions are biased on any decision sequence of fixed length. We introduce
    *fairness shielding*, where a symbolic decision-maker---the fairness shield---continuously
    monitors the sequence of decisions of another deployed black-box decision-maker,
    and makes interventions so that a given fairness criterion is met while the total
    intervention costs are minimized. We present four different algorithms for computing
    fairness shields, among which one guarantees fairness over fixed horizons, and
    three guarantee fairness periodically after fixed intervals. Given a distribution
    over future decisions and their intervention costs, our algorithms solve different
    instances of bounded-horizon optimal control problems with different levels of
    computational costs and optimality guarantees. Our empirical evaluation demonstrates
    the effectiveness of these shields in ensuring fairness while maintaining cost
    efficiency across various scenarios.
acknowledgement: 'This work is partly supported by the European Research Council under
  Grant No.: ERC-2020-AdG 101020093. It is also partially supported by the State Government
  of Styria, Austria – Department Zukunftsfonds Steiermark.'
article_processing_charge: No
arxiv: 1
author:
- first_name: Filip
  full_name: Cano Cordoba, Filip
  id: 708cad98-e86a-11ef-8098-bdae2d7c6af1
  last_name: Cano Cordoba
  orcid: 0000-0002-0783-904X
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000-0002-2985-7724
- first_name: Bettina
  full_name: Könighofer, Bettina
  last_name: Könighofer
- first_name: Konstantin
  full_name: Kueffner, Konstantin
  id: 8121a2d0-dc85-11ea-9058-af578f3b4515
  last_name: Kueffner
  orcid: 0000-0001-8974-2542
- first_name: Kaushik
  full_name: Mallik, Kaushik
  id: 0834ff3c-6d72-11ec-94e0-b5b0a4fb8598
  last_name: Mallik
  orcid: 0000-0001-9864-7475
citation:
  ama: 'Cano Cordoba F, Henzinger TA, Könighofer B, Kueffner K, Mallik K. Fairness
    shields: Safeguarding against biased decision makers. In: <i>Proceedings of the
    39th AAAI Conference on Artificial Intelligence</i>. Vol 39. Association for the
    Advancement of Artificial Intelligence; 2025:15659-15668. doi:<a href="https://doi.org/10.1609/aaai.v39i15.33719">10.1609/aaai.v39i15.33719</a>'
  apa: 'Cano Cordoba, F., Henzinger, T. A., Könighofer, B., Kueffner, K., &#38; Mallik,
    K. (2025). Fairness shields: Safeguarding against biased decision makers. In <i>Proceedings
    of the 39th AAAI Conference on Artificial Intelligence</i> (Vol. 39, pp. 15659–15668).
    Philadelphia, PA, United States: Association for the Advancement of Artificial
    Intelligence. <a href="https://doi.org/10.1609/aaai.v39i15.33719">https://doi.org/10.1609/aaai.v39i15.33719</a>'
  chicago: 'Cano Cordoba, Filip, Thomas A Henzinger, Bettina Könighofer, Konstantin
    Kueffner, and Kaushik Mallik. “Fairness Shields: Safeguarding against Biased Decision
    Makers.” In <i>Proceedings of the 39th AAAI Conference on Artificial Intelligence</i>,
    39:15659–68. Association for the Advancement of Artificial Intelligence, 2025.
    <a href="https://doi.org/10.1609/aaai.v39i15.33719">https://doi.org/10.1609/aaai.v39i15.33719</a>.'
  ieee: 'F. Cano Cordoba, T. A. Henzinger, B. Könighofer, K. Kueffner, and K. Mallik,
    “Fairness shields: Safeguarding against biased decision makers,” in <i>Proceedings
    of the 39th AAAI Conference on Artificial Intelligence</i>, Philadelphia, PA,
    United States, 2025, vol. 39, no. 15, pp. 15659–15668.'
  ista: 'Cano Cordoba F, Henzinger TA, Könighofer B, Kueffner K, Mallik K. 2025. Fairness
    shields: Safeguarding against biased decision makers. Proceedings of the 39th
    AAAI Conference on Artificial Intelligence. AAAI: Conference on Artificial Intelligence
    vol. 39, 15659–15668.'
  mla: 'Cano Cordoba, Filip, et al. “Fairness Shields: Safeguarding against Biased
    Decision Makers.” <i>Proceedings of the 39th AAAI Conference on Artificial Intelligence</i>,
    vol. 39, no. 15, Association for the Advancement of Artificial Intelligence, 2025,
    pp. 15659–68, doi:<a href="https://doi.org/10.1609/aaai.v39i15.33719">10.1609/aaai.v39i15.33719</a>.'
  short: F. Cano Cordoba, T.A. Henzinger, B. Könighofer, K. Kueffner, K. Mallik, in:,
    Proceedings of the 39th AAAI Conference on Artificial Intelligence, Association
    for the Advancement of Artificial Intelligence, 2025, pp. 15659–15668.
conference:
  end_date: 2025-03-04
  location: Philadelphia, PA, United States
  name: 'AAAI: Conference on Artificial Intelligence'
  start_date: 2025-02-25
corr_author: '1'
date_created: 2025-05-11T22:02:39Z
date_published: 2025-04-11T00:00:00Z
date_updated: 2026-02-16T12:24:30Z
day: '11'
department:
- _id: ToHe
doi: 10.1609/aaai.v39i15.33719
ec_funded: 1
external_id:
  arxiv:
  - '2412.11994'
fulldoi: https://doi.org/10.1609/aaai.v39i15.33719
intvolume: '        39'
issue: '15'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2412.11994
month: '04'
oa: 1
oa_version: Preprint
page: 15659-15668
project:
- _id: 62781420-2b32-11ec-9570-8d9b63373d4d
  call_identifier: H2020
  grant_number: '101020093'
  name: Vigilant Algorithmic Monitoring of Software
publication: Proceedings of the 39th AAAI Conference on Artificial Intelligence
publication_identifier:
  eissn:
  - 2374-3468
  issn:
  - 2159-5399
publication_status: published
publisher: Association for the Advancement of Artificial Intelligence
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Fairness shields: Safeguarding against biased decision makers'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 39
year: '2025'
...
---
OA_place: repository
OA_type: green
_id: '19666'
abstract:
- lang: eng
  text: Markov decision processes (MDP) are a well-established model for sequential
    decision-making in the presence of probabilities. In *robust* MDP (RMDP), every
    action is associated with an *uncertainty set* of probability distributions, modelling
    that transition probabilities are not known precisely. Based on the known theoretical
    connection to stochastic games, we provide a framework for solving RMDPs that
    is generic, reliable, and efficient. It is *generic* both with respect to the
    model, allowing for a wide range of uncertainty sets, including but not limited
    to intervals, L1- or L2-balls, and polytopes; and with respect to the objective,
    including long-run average reward, undiscounted total reward, and stochastic shortest
    path. It is *reliable*, as our approach not only converges in the limit, but provides
    precision guarantees at any time during the computation. It is *efficient* because
    -- in contrast to state-of-the-art approaches -- it avoids explicitly constructing
    the underlying stochastic game. Consequently, our prototype implementation outperforms
    existing tools by several orders of magnitude and can solve RMDPs with a million
    states in under a minute.
acknowledgement: "This project has received funding from the European Union’s Horizon
  2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement
  No. 101034413,\r\nthe ERC CoG 863818 (ForM-SMArt), and the DFG through the Cluster
  of Excellence EXC 2050/1 (CeTI, project ID 390696704, as part of Germany’s Excellence
  Strategy) and the TRR 248 (see https://perspicuous-computing.science, project ID
  389792660)."
article_processing_charge: No
arxiv: 1
author:
- first_name: Tobias
  full_name: Meggendorfer, Tobias
  id: b21b0c15-30a2-11eb-80dc-f13ca25802e1
  last_name: Meggendorfer
  orcid: 0000-0002-1712-2165
- first_name: Maximilian
  full_name: Weininger, Maximilian
  id: 02ab0197-cc70-11ed-ab61-918e71f56881
  last_name: Weininger
  orcid: 0000-0002-0163-2152
- first_name: Patrick
  full_name: Wienhöft, Patrick
  last_name: Wienhöft
citation:
  ama: 'Meggendorfer T, Weininger M, Wienhöft P. Solving robust Markov decision processes:
    Generic, reliable, efficient. In: <i>Proceedings of the 39th AAAI Conference on
    Artificial Intelligence</i>. Vol 39. Association for the Advancement of Artificial
    Intelligence; 2025:26631-26641. doi:<a href="https://doi.org/10.1609/aaai.v39i25.34865">10.1609/aaai.v39i25.34865</a>'
  apa: 'Meggendorfer, T., Weininger, M., &#38; Wienhöft, P. (2025). Solving robust
    Markov decision processes: Generic, reliable, efficient. In <i>Proceedings of
    the 39th AAAI Conference on Artificial Intelligence</i> (Vol. 39, pp. 26631–26641).
    Philadelphia, PA, United States: Association for the Advancement of Artificial
    Intelligence. <a href="https://doi.org/10.1609/aaai.v39i25.34865">https://doi.org/10.1609/aaai.v39i25.34865</a>'
  chicago: 'Meggendorfer, Tobias, Maximilian Weininger, and Patrick Wienhöft. “Solving
    Robust Markov Decision Processes: Generic, Reliable, Efficient.” In <i>Proceedings
    of the 39th AAAI Conference on Artificial Intelligence</i>, 39:26631–41. Association
    for the Advancement of Artificial Intelligence, 2025. <a href="https://doi.org/10.1609/aaai.v39i25.34865">https://doi.org/10.1609/aaai.v39i25.34865</a>.'
  ieee: 'T. Meggendorfer, M. Weininger, and P. Wienhöft, “Solving robust Markov decision
    processes: Generic, reliable, efficient,” in <i>Proceedings of the 39th AAAI Conference
    on Artificial Intelligence</i>, Philadelphia, PA, United States, 2025, vol. 39,
    no. 25, pp. 26631–26641.'
  ista: 'Meggendorfer T, Weininger M, Wienhöft P. 2025. Solving robust Markov decision
    processes: Generic, reliable, efficient. Proceedings of the 39th AAAI Conference
    on Artificial Intelligence. AAAI: Conference on Artificial Intelligence vol. 39,
    26631–26641.'
  mla: 'Meggendorfer, Tobias, et al. “Solving Robust Markov Decision Processes: Generic,
    Reliable, Efficient.” <i>Proceedings of the 39th AAAI Conference on Artificial
    Intelligence</i>, vol. 39, no. 25, Association for the Advancement of Artificial
    Intelligence, 2025, pp. 26631–41, doi:<a href="https://doi.org/10.1609/aaai.v39i25.34865">10.1609/aaai.v39i25.34865</a>.'
  short: T. Meggendorfer, M. Weininger, P. Wienhöft, in:, Proceedings of the 39th
    AAAI Conference on Artificial Intelligence, Association for the Advancement of
    Artificial Intelligence, 2025, pp. 26631–26641.
conference:
  end_date: 2025-03-04
  location: Philadelphia, PA, United States
  name: 'AAAI: Conference on Artificial Intelligence'
  start_date: 2025-02-25
date_created: 2025-05-11T22:02:39Z
date_published: 2025-04-11T00:00:00Z
date_updated: 2026-02-16T12:25:05Z
day: '11'
department:
- _id: KrCh
doi: 10.1609/aaai.v39i25.34865
ec_funded: 1
external_id:
  arxiv:
  - '2412.10185'
fulldoi: https://doi.org/10.1609/aaai.v39i25.34865
intvolume: '        39'
issue: '25'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2412.10185
month: '04'
oa: 1
oa_version: Preprint
page: 26631-26641
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
  call_identifier: H2020
  grant_number: '863818'
  name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
publication: Proceedings of the 39th AAAI Conference on Artificial Intelligence
publication_identifier:
  eissn:
  - 2374-3468
  issn:
  - 2159-5399
publication_status: published
publisher: Association for the Advancement of Artificial Intelligence
quality_controlled: '1'
related_material:
  link:
  - relation: software
    url: https://doi.org/10.5281/zenodo.14385449
scopus_import: '1'
status: public
title: 'Solving robust Markov decision processes: Generic, reliable, efficient'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 39
year: '2025'
...
---
OA_place: repository
OA_type: green
_id: '19668'
abstract:
- lang: eng
  text: Learning-based methods provide a promising approach to solving highly non-linear
    control tasks that are often challenging for classical control methods. To ensure
    the satisfaction of a safety property, learning-based methods jointly learn a
    control policy together with a certificate function for the property. Popular
    examples include barrier functions for safety and Lyapunov functions for asymptotic
    stability. While there has been significant progress on learning-based control
    with certificate functions in the white-box setting, where the correctness of
    the certificate function can be formally verified, there has been little work
    on ensuring their reliability in the black-box setting where the system dynamics
    are unknown. In this work, we consider the problems of certifying and repairing
    neural network control policies and certificate functions in the black-box setting.
    We propose a novel framework that utilizes runtime monitoring to detect system
    behaviors that violate the property of interest under some initially trained neural
    network policy and certificate. These violating behaviors are used to extract
    new training data, that is used to re-train the neural network policy and the
    certificate function and to ultimately repair them. We demonstrate the effectiveness
    of our approach empirically by using it to repair and to boost the safety rate
    of neural network policies learned by a state-of-the-art method for learning-based
    control on two autonomous system control tasks.
acknowledgement: This work was supported in part by the ERC project ERC2020-AdG 101020093
article_processing_charge: No
arxiv: 1
author:
- first_name: Zhengqi
  full_name: Yu, Zhengqi
  id: 20aa2ae8-f2f1-11ed-bbfa-8205053f1342
  last_name: Yu
- first_name: Dorde
  full_name: Zikelic, Dorde
  id: 294AA7A6-F248-11E8-B48F-1D18A9856A87
  last_name: Zikelic
  orcid: 0000-0002-4681-1699
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000-0002-2985-7724
citation:
  ama: 'Yu E, Zikelic D, Henzinger TA. Neural control and certificate repair via runtime
    monitoring. In: <i>Proceedings of the 39th AAAI Conference on Artificial Intelligence</i>.
    Vol 39. Association for the Advancement of Artificial Intelligence; 2025:26409-26417.
    doi:<a href="https://doi.org/10.1609/aaai.v39i25.34840">10.1609/aaai.v39i25.34840</a>'
  apa: 'Yu, E., Zikelic, D., &#38; Henzinger, T. A. (2025). Neural control and certificate
    repair via runtime monitoring. In <i>Proceedings of the 39th AAAI Conference on
    Artificial Intelligence</i> (Vol. 39, pp. 26409–26417). Philadelphia, PA, United
    States: Association for the Advancement of Artificial Intelligence. <a href="https://doi.org/10.1609/aaai.v39i25.34840">https://doi.org/10.1609/aaai.v39i25.34840</a>'
  chicago: Yu, Emily, Dorde Zikelic, and Thomas A Henzinger. “Neural Control and Certificate
    Repair via Runtime Monitoring.” In <i>Proceedings of the 39th AAAI Conference
    on Artificial Intelligence</i>, 39:26409–17. Association for the Advancement of
    Artificial Intelligence, 2025. <a href="https://doi.org/10.1609/aaai.v39i25.34840">https://doi.org/10.1609/aaai.v39i25.34840</a>.
  ieee: E. Yu, D. Zikelic, and T. A. Henzinger, “Neural control and certificate repair
    via runtime monitoring,” in <i>Proceedings of the 39th AAAI Conference on Artificial
    Intelligence</i>, Philadelphia, PA, United States, 2025, vol. 39, no. 25, pp.
    26409–26417.
  ista: 'Yu E, Zikelic D, Henzinger TA. 2025. Neural control and certificate repair
    via runtime monitoring. Proceedings of the 39th AAAI Conference on Artificial
    Intelligence. AAAI: Conference on Artificial Intelligence vol. 39, 26409–26417.'
  mla: Yu, Emily, et al. “Neural Control and Certificate Repair via Runtime Monitoring.”
    <i>Proceedings of the 39th AAAI Conference on Artificial Intelligence</i>, vol.
    39, no. 25, Association for the Advancement of Artificial Intelligence, 2025,
    pp. 26409–17, doi:<a href="https://doi.org/10.1609/aaai.v39i25.34840">10.1609/aaai.v39i25.34840</a>.
  short: E. Yu, D. Zikelic, T.A. Henzinger, in:, Proceedings of the 39th AAAI Conference
    on Artificial Intelligence, Association for the Advancement of Artificial Intelligence,
    2025, pp. 26409–26417.
conference:
  end_date: 2025-03-04
  location: Philadelphia, PA, United States
  name: 'AAAI: Conference on Artificial Intelligence'
  start_date: 2025-02-25
corr_author: '1'
date_created: 2025-05-11T22:02:40Z
date_published: 2025-04-11T00:00:00Z
date_updated: 2025-05-12T09:49:25Z
day: '11'
department:
- _id: ToHe
doi: 10.1609/aaai.v39i25.34840
ec_funded: 1
external_id:
  arxiv:
  - '2412.12996'
fulldoi: https://doi.org/10.1609/aaai.v39i25.34840
intvolume: '        39'
issue: '25'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2412.12996
month: '04'
oa: 1
oa_version: Preprint
page: 26409-26417
project:
- _id: 62781420-2b32-11ec-9570-8d9b63373d4d
  call_identifier: H2020
  grant_number: '101020093'
  name: Vigilant Algorithmic Monitoring of Software
publication: Proceedings of the 39th AAAI Conference on Artificial Intelligence
publication_identifier:
  eissn:
  - 2374-3468
  issn:
  - 2159-5399
publication_status: published
publisher: Association for the Advancement of Artificial Intelligence
quality_controlled: '1'
scopus_import: '1'
status: public
title: Neural control and certificate repair via runtime monitoring
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 39
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
_id: '19670'
abstract:
- lang: eng
  text: “Pasta alla Cacio e pepe” is a traditional Italian dish made with pasta, pecorino
    cheese, and pepper. Despite its simple ingredient list, achieving the perfect
    texture and creaminess of the sauce can be challenging. In this study, we systematically
    explore the phase behavior of Cacio e pepe sauce, focusing on its stability at
    increasing temperatures for various proportions of cheese, water, and starch.
    We identify starch concentration as the key factor influencing sauce stability,
    with direct implications for practical cooking. Specifically, we delineate a regime
    where starch concentrations below 1% (relative to cheese mass) lead to the formation
    of system-wide clumps, a condition determining what we term the “Mozzarella Phase”
    and corresponding to an unpleasant and separated sauce. Additionally, we examine
    the impact of cheese concentration relative to water at a fixed starch level,
    observing a lower critical solution temperature that we theoretically rationalized
    by means of a minimal effective free-energy model. We further analyze the effect
    of a less traditional stabilizer, trisodium citrate, and observe a sharp transition
    from the Mozzarella Phase to a completely smooth and stable sauce, in contrast
    to starch-stabilized mixtures, where the transition is more gradual. Finally,
    we present a scientifically optimized recipe based on our findings, enabling a
    consistently flawless execution of this classic dish.
acknowledgement: he authors thank Frank Jülicher, for supporting the initiative and
  stimulating discussions. We thank Tetsuya Spippayashi for enlightening clarifications
  on the historical origins of Cacio e pepe and Giuseppe Ricchitelli for helping with
  the construction of the experimental apparatus. We further thank Martina Gaiba,
  Alessandro Gaiba, John D. Treado, Virginia Lepore, Eleonora Nanu, Julia Kirsch,
  Lara Koehler, Burak Budanur, Irina Pi-Jaumà, Elizabeth Brückner, M.J. Franco Oñate,
  Giorgio Nicoletti, and Marco Salvalaglio for their support and for eating up the
  sample leftovers. Finally, we thank Simone Frau for taking the photograph in Fig.
  1(a).
article_number: '044122'
article_processing_charge: Yes (in subscription journal)
article_type: original
arxiv: 1
author:
- first_name: G.
  full_name: Bartolucci, G.
  last_name: Bartolucci
- first_name: D. M.
  full_name: Busiello, D. M.
  last_name: Busiello
- first_name: M.
  full_name: Ciarchi, M.
  last_name: Ciarchi
- first_name: A.
  full_name: Corticelli, A.
  last_name: Corticelli
- first_name: I.
  full_name: Di Terlizzi, I.
  last_name: Di Terlizzi
- first_name: Fabrizio
  full_name: Olmeda, Fabrizio
  id: 69dbf5fb-8a76-11ed-866b-fb486d8b5689
  last_name: Olmeda
- first_name: D.
  full_name: Revignas, D.
  last_name: Revignas
- first_name: V. M.
  full_name: Schimmenti, V. M.
  last_name: Schimmenti
citation:
  ama: Bartolucci G, Busiello DM, Ciarchi M, et al. Phase behavior of Cacio e Pepe
    sauce. <i>Physics of Fluids</i>. 2025;37(4). doi:<a href="https://doi.org/10.1063/5.0255841">10.1063/5.0255841</a>
  apa: Bartolucci, G., Busiello, D. M., Ciarchi, M., Corticelli, A., Di Terlizzi,
    I., Olmeda, F., … Schimmenti, V. M. (2025). Phase behavior of Cacio e Pepe sauce.
    <i>Physics of Fluids</i>. AIP Publishing. <a href="https://doi.org/10.1063/5.0255841">https://doi.org/10.1063/5.0255841</a>
  chicago: Bartolucci, G., D. M. Busiello, M. Ciarchi, A. Corticelli, I. Di Terlizzi,
    Fabrizio Olmeda, D. Revignas, and V. M. Schimmenti. “Phase Behavior of Cacio e
    Pepe Sauce.” <i>Physics of Fluids</i>. AIP Publishing, 2025. <a href="https://doi.org/10.1063/5.0255841">https://doi.org/10.1063/5.0255841</a>.
  ieee: G. Bartolucci <i>et al.</i>, “Phase behavior of Cacio e Pepe sauce,” <i>Physics
    of Fluids</i>, vol. 37, no. 4. AIP Publishing, 2025.
  ista: Bartolucci G, Busiello DM, Ciarchi M, Corticelli A, Di Terlizzi I, Olmeda
    F, Revignas D, Schimmenti VM. 2025. Phase behavior of Cacio e Pepe sauce. Physics
    of Fluids. 37(4), 044122.
  mla: Bartolucci, G., et al. “Phase Behavior of Cacio e Pepe Sauce.” <i>Physics of
    Fluids</i>, vol. 37, no. 4, 044122, AIP Publishing, 2025, doi:<a href="https://doi.org/10.1063/5.0255841">10.1063/5.0255841</a>.
  short: G. Bartolucci, D.M. Busiello, M. Ciarchi, A. Corticelli, I. Di Terlizzi,
    F. Olmeda, D. Revignas, V.M. Schimmenti, Physics of Fluids 37 (2025).
date_created: 2025-05-11T22:02:40Z
date_published: 2025-04-01T00:00:00Z
date_updated: 2026-04-28T13:24:53Z
day: '01'
ddc:
- '530'
department:
- _id: EdHa
doi: 10.1063/5.0255841
external_id:
  arxiv:
  - '2501.00536'
  isi:
  - '001482986200001'
file:
- access_level: open_access
  checksum: 242d05898aa0a2348b9c108747adb5ce
  content_type: application/pdf
  creator: dernst
  date_created: 2025-05-12T09:31:22Z
  date_updated: 2025-05-12T09:31:22Z
  file_id: '19681'
  file_name: 2025_PhysicsFluids_Bartolucci.pdf
  file_size: 4926853
  relation: main_file
  success: 1
file_date_updated: 2025-05-12T09:31:22Z
fulldoi: https://doi.org/10.1063/5.0255841
has_accepted_license: '1'
intvolume: '        37'
isi: 1
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
publication: Physics of Fluids
publication_identifier:
  eissn:
  - 1089-7666
  issn:
  - 1070-6631
publication_status: published
publisher: AIP Publishing
quality_controlled: '1'
related_material:
  link:
  - description: News on ISTA
    relation: press_release
    url: https://ista.ac.at/en/news/2025-ig-nobel-prize-for-perfect-pasta-sauce/
scopus_import: '1'
status: public
title: Phase behavior of Cacio e Pepe sauce
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 37
year: '2025'
...
---
OA_type: closed access
_id: '19671'
abstract:
- lang: eng
  text: Silvopastoral use in native forests could impact population dynamics of key
    tree species, with contrasting effects at different life cycle stages. Prior studies
    in South American temperate forests have mainly focused on initial stages, lacking
    a comprehensive understanding of the entire life cycle within productive systems.
    We assessed the population dynamics of two key species of mixed forests in northern
    Patagonia (Austrocedrus chilensis and Nothofagus dombeyi) under two silvopastoral
    use intensities (high vs. low), using demographic techniques and population projection
    models. Over 3 years, we quantified vital rates (survival, fertility, growth,
    reversion and stasis) and used matrix models to calculate deterministic population
    growth rates (λ). High-intensity silvopastoral use had predominantly negative
    effects on the elements of the projection matrices of A. chilensis, whereas N.
    dombeyi exhibited mostly positive or no changes. As a result, projections indicated
    slight population decreases for A. chilensis (mostly λ < 1) at high silvopastoral
    use levels compared to low levels, while N. dombeyi showed similar projections
    (λ ≅ 1) between use levels. Decreased λ for A. chilensis resulted mainly from
    lower adult tree survival, while early life stages had limited influence on λ
    for these long-lived species. In summary, silvopastoral use affects population
    dynamics of key tree species of these mixed forests of northern Patagonia, with
    implications for sustainable management. Our findings highlight the importance
    of considering the entire life cycle and suggest targeted practices to enhance
    A. chilensis populations.
acknowledgement: We would like to express our sincere gratitude to the owners of the
  estates, Lisandro and Oscar Lanfré, Roberto Criado and Yayo Tillería, for allowing
  us to conduct our research on their properties and for generously sharing their
  time and knowledge throughout these years. We are also deeply thankful to our field
  assistants, Matías Scotti, Clara Pissolito, Noel Szudruk, Mariano Varela, Ian Mott,
  Brisa Guenuleo, Nicolás Bistolfi, Facundo Gómez and Belén Vallerga, who tirelessly
  collaborated in the arduous tasks of monitoring and data collection, even in challenging
  weather conditions. We are grateful to CONICET for providing the doctoral scholarship
  to D. Arpigiani. This study received partial financial support from the Agencia
  MINCyT (PICT 2015-1692) and the Universidad Nacional de Río Negro (PI 40-B-478),
  Argentina.
article_number: e70058
article_processing_charge: No
article_type: original
author:
- first_name: Daniela
  full_name: Arpigiani, Daniela
  last_name: Arpigiani
- first_name: Valeria
  full_name: Aschero, Valeria
  last_name: Aschero
- first_name: Rosina Matilde
  full_name: Soler Schaller, Rosina Matilde
  id: 9e668447-8c32-11ed-b0c7-8dc2d7b80803
  last_name: Soler Schaller
- first_name: Mariano M.
  full_name: Amoroso, Mariano M.
  last_name: Amoroso
citation:
  ama: Arpigiani D, Aschero V, Soler Schaller RM, Amoroso MM. A life-cycle approach
    to understand consequences of silvopastoral use on two native tree species of
    Northern Patagonia. <i>Austral Ecology</i>. 2025;50(4). doi:<a href="https://doi.org/10.1111/aec.70058">10.1111/aec.70058</a>
  apa: Arpigiani, D., Aschero, V., Soler Schaller, R. M., &#38; Amoroso, M. M. (2025).
    A life-cycle approach to understand consequences of silvopastoral use on two native
    tree species of Northern Patagonia. <i>Austral Ecology</i>. Wiley. <a href="https://doi.org/10.1111/aec.70058">https://doi.org/10.1111/aec.70058</a>
  chicago: Arpigiani, Daniela, Valeria Aschero, Rosina Matilde Soler Schaller, and
    Mariano M. Amoroso. “A Life-Cycle Approach to Understand Consequences of Silvopastoral
    Use on Two Native Tree Species of Northern Patagonia.” <i>Austral Ecology</i>.
    Wiley, 2025. <a href="https://doi.org/10.1111/aec.70058">https://doi.org/10.1111/aec.70058</a>.
  ieee: D. Arpigiani, V. Aschero, R. M. Soler Schaller, and M. M. Amoroso, “A life-cycle
    approach to understand consequences of silvopastoral use on two native tree species
    of Northern Patagonia,” <i>Austral Ecology</i>, vol. 50, no. 4. Wiley, 2025.
  ista: Arpigiani D, Aschero V, Soler Schaller RM, Amoroso MM. 2025. A life-cycle
    approach to understand consequences of silvopastoral use on two native tree species
    of Northern Patagonia. Austral Ecology. 50(4), e70058.
  mla: Arpigiani, Daniela, et al. “A Life-Cycle Approach to Understand Consequences
    of Silvopastoral Use on Two Native Tree Species of Northern Patagonia.” <i>Austral
    Ecology</i>, vol. 50, no. 4, e70058, Wiley, 2025, doi:<a href="https://doi.org/10.1111/aec.70058">10.1111/aec.70058</a>.
  short: D. Arpigiani, V. Aschero, R.M. Soler Schaller, M.M. Amoroso, Austral Ecology
    50 (2025).
date_created: 2025-05-11T22:02:41Z
date_published: 2025-04-01T00:00:00Z
date_updated: 2025-09-30T12:31:04Z
day: '01'
department:
- _id: NiBa
doi: 10.1111/aec.70058
external_id:
  isi:
  - '001476761500001'
fulldoi: https://doi.org/10.1111/aec.70058
intvolume: '        50'
isi: 1
issue: '4'
language:
- iso: eng
month: '04'
oa_version: None
publication: Austral Ecology
publication_identifier:
  eissn:
  - 1442-9993
  issn:
  - 1442-9985
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: A life-cycle approach to understand consequences of silvopastoral use on two
  native tree species of Northern Patagonia
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 50
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '19672'
abstract:
- lang: eng
  text: 'Some of the classical models of tropical cyclone intensification predict
    tropical cyclones to intensify up to a steady intensity, which depends on surface
    fluxes only, without any relevant role played by convective motions in the troposphere,
    typically assumed to have a moist adiabatic lapse rate. Simulations performed
    using the non-hydrostatic, high-resolution model System for Atmosphere Modeling
    in idealized settings (rotating radiative-convective equilibrium on a doubly periodic
    domain) show early intensification consistent with these theoretical expectations,
    but different intensity evolution, with the cyclone undergoing an oscillation
    in wind speed. This oscillation can be linked to feedbacks between the cyclone
    intensity and air buoyancy: convective heating, radiative heating, and mixing
    with warm low stratospheric air warm the mid and upper troposphere of the cyclone
    stabilizing the air column and thus reducing its intensity. After the intensity
    decay phase, mid and upper tropospheric cooling, mostly through cold advection
    from the surroundings, cooled by radiation, rebuilds Convective Available Potential
    Energy, that peaks just before a new intensification phase. These idealized simulations
    thus highlight the potentially important interactions between a tropical cyclone,
    its environment and radiation.'
acknowledgement: The authors acknowledge two anonymous reviewers and the editor who
  provided insightful remarks and comments that helped to significantly improve the
  manuscript. AP and CJM gratefully acknowledges funding from the European Research
  Council (ERC) under the European Union's Horizon 2020 research and innovation program
  (Project CLUSTER, Grant Agreement No. 805041). Part of this work is an outcome of
  the project MIUR—Dipartimenti di Eccellenza 2023–2027. ANM is supported by HPC-TRES
  Grant 2023-04.
article_number: e2024MS004613
article_processing_charge: Yes
article_type: original
author:
- first_name: Andrea
  full_name: Polesello, Andrea
  id: 74c777f4-32da-11ee-b498-874db0835561
  last_name: Polesello
- first_name: Giousef Alexandros
  full_name: Charinti, Giousef Alexandros
  id: 7f7cc04c-074c-11ed-af92-eb16afd85c75
  last_name: Charinti
- first_name: Agostino Niyonkuru
  full_name: Meroni, Agostino Niyonkuru
  last_name: Meroni
- first_name: Caroline J
  full_name: Muller, Caroline J
  id: f978ccb0-3f7f-11eb-b193-b0e2bd13182b
  last_name: Muller
  orcid: 0000-0001-5836-5350
- first_name: Claudia
  full_name: Pasquero, Claudia
  last_name: Pasquero
citation:
  ama: 'Polesello A, Charinti GA, Meroni AN, Muller CJ, Pasquero C. Intensity oscillations
    of tropical cyclones: Surface versus mid and upper tropospheric processes. <i>Journal
    of Advances in Modeling Earth Systems</i>. 2025;17(4). doi:<a href="https://doi.org/10.1029/2024MS004613">10.1029/2024MS004613</a>'
  apa: 'Polesello, A., Charinti, G. A., Meroni, A. N., Muller, C. J., &#38; Pasquero,
    C. (2025). Intensity oscillations of tropical cyclones: Surface versus mid and
    upper tropospheric processes. <i>Journal of Advances in Modeling Earth Systems</i>.
    Wiley. <a href="https://doi.org/10.1029/2024MS004613">https://doi.org/10.1029/2024MS004613</a>'
  chicago: 'Polesello, Andrea, Giousef Alexandros Charinti, Agostino Niyonkuru Meroni,
    Caroline J Muller, and Claudia Pasquero. “Intensity Oscillations of Tropical Cyclones:
    Surface versus Mid and Upper Tropospheric Processes.” <i>Journal of Advances in
    Modeling Earth Systems</i>. Wiley, 2025. <a href="https://doi.org/10.1029/2024MS004613">https://doi.org/10.1029/2024MS004613</a>.'
  ieee: 'A. Polesello, G. A. Charinti, A. N. Meroni, C. J. Muller, and C. Pasquero,
    “Intensity oscillations of tropical cyclones: Surface versus mid and upper tropospheric
    processes,” <i>Journal of Advances in Modeling Earth Systems</i>, vol. 17, no.
    4. Wiley, 2025.'
  ista: 'Polesello A, Charinti GA, Meroni AN, Muller CJ, Pasquero C. 2025. Intensity
    oscillations of tropical cyclones: Surface versus mid and upper tropospheric processes.
    Journal of Advances in Modeling Earth Systems. 17(4), e2024MS004613.'
  mla: 'Polesello, Andrea, et al. “Intensity Oscillations of Tropical Cyclones: Surface
    versus Mid and Upper Tropospheric Processes.” <i>Journal of Advances in Modeling
    Earth Systems</i>, vol. 17, no. 4, e2024MS004613, Wiley, 2025, doi:<a href="https://doi.org/10.1029/2024MS004613">10.1029/2024MS004613</a>.'
  short: A. Polesello, G.A. Charinti, A.N. Meroni, C.J. Muller, C. Pasquero, Journal
    of Advances in Modeling Earth Systems 17 (2025).
corr_author: '1'
date_created: 2025-05-11T22:02:41Z
date_published: 2025-04-01T00:00:00Z
date_updated: 2025-09-30T12:30:29Z
day: '01'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1029/2024MS004613
ec_funded: 1
external_id:
  isi:
  - '001472439600001'
file:
- access_level: open_access
  checksum: 2f7c74aceaeea4be1fff4de300791319
  content_type: application/pdf
  creator: dernst
  date_created: 2025-05-12T12:17:08Z
  date_updated: 2025-05-12T12:17:08Z
  file_id: '19683'
  file_name: 2025_JAMES_Polesello.pdf
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  success: 1
file_date_updated: 2025-05-12T12:17:08Z
fulldoi: https://doi.org/10.1029/2024MS004613
has_accepted_license: '1'
intvolume: '        17'
isi: 1
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: 629205d8-2b32-11ec-9570-e1356ff73576
  call_identifier: H2020
  grant_number: '805041'
  name: Organization of CLoUdS, and implications of Tropical  cyclones and for the
    Energetics of the tropics, in current and waRming climate
publication: Journal of Advances in Modeling Earth Systems
publication_identifier:
  eissn:
  - 1942-2466
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Intensity oscillations of tropical cyclones: Surface versus mid and upper
  tropospheric processes'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 17
year: '2025'
...
---
_id: '19696'
acknowledged_ssus:
- _id: NMR
- _id: LifeSc
article_processing_charge: No
author:
- first_name: Benjamin
  full_name: Tatman, Benjamin
  id: 71cda2f3-e604-11ee-a1df-da10587eda3f
  last_name: Tatman
citation:
  ama: 'Tatman B. Dataset for “Bumps on the Road: The Way to Clean Relaxation Dispersion
    in the Solid State.” 2025. doi:<a href="https://doi.org/10.15479/AT-ISTA-19696">10.15479/AT-ISTA-19696</a>'
  apa: 'Tatman, B. (2025). Dataset for “Bumps on the Road: The Way to Clean Relaxation
    Dispersion in the Solid State.” Institute of Science and Technology Austria. <a
    href="https://doi.org/10.15479/AT-ISTA-19696">https://doi.org/10.15479/AT-ISTA-19696</a>'
  chicago: 'Tatman, Benjamin. “Dataset for ‘Bumps on the Road: The Way to Clean Relaxation
    Dispersion in the Solid State.’” Institute of Science and Technology Austria,
    2025. <a href="https://doi.org/10.15479/AT-ISTA-19696">https://doi.org/10.15479/AT-ISTA-19696</a>.'
  ieee: 'B. Tatman, “Dataset for ‘Bumps on the Road: The Way to Clean Relaxation Dispersion
    in the Solid State.’” Institute of Science and Technology Austria, 2025.'
  ista: 'Tatman B. 2025. Dataset for ‘Bumps on the Road: The Way to Clean Relaxation
    Dispersion in the Solid State’, Institute of Science and Technology Austria, <a
    href="https://doi.org/10.15479/AT-ISTA-19696">10.15479/AT-ISTA-19696</a>.'
  mla: 'Tatman, Benjamin. <i>Dataset for “Bumps on the Road: The Way to Clean Relaxation
    Dispersion in the Solid State.”</i> Institute of Science and Technology Austria,
    2025, doi:<a href="https://doi.org/10.15479/AT-ISTA-19696">10.15479/AT-ISTA-19696</a>.'
  short: B. Tatman, (2025).
contributor:
- contributor_type: project_leader
  first_name: Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
- contributor_type: researcher
  first_name: Vidhyalakshmi
  last_name: Sridharan
- contributor_type: researcher
  first_name: Motilal
  last_name: Uttarkabat
- contributor_type: researcher
  first_name: Christopher
  last_name: Jaroniec
- contributor_type: researcher
  first_name: Matthias
  last_name: Ernst
- contributor_type: researcher
  first_name: Petra
  id: c316e53f-b965-11eb-b128-bb26acc59c00
  last_name: Rovo
  orcid: 0000-0001-8729-7326
corr_author: '1'
date_created: 2025-05-14T10:46:07Z
date_published: 2025-07-31T00:00:00Z
date_updated: 2026-06-10T08:33:41Z
day: '31'
department:
- _id: PaSc
doi: 10.15479/AT-ISTA-19696
file:
- access_level: open_access
  checksum: 4c2d29404e070bda7d5619f728ec555c
  content_type: application/zip
  creator: btatman
  date_created: 2025-07-31T08:14:40Z
  date_updated: 2025-07-31T08:14:40Z
  file_id: '20094'
  file_name: dataset.zip
  file_size: 557878455
  relation: main_file
  success: 1
- access_level: open_access
  checksum: 6cbccd602be0ecb6ddb1f81fdfcadf92
  content_type: text/plain
  creator: btatman
  date_created: 2025-07-31T08:14:21Z
  date_updated: 2025-07-31T08:14:21Z
  file_id: '20095'
  file_name: readme.txt
  file_size: 3514
  relation: main_file
  success: 1
file_date_updated: 2025-07-31T08:14:40Z
fulldoi: https://doi.org/10.15479/AT-ISTA-19696
has_accepted_license: '1'
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '07'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
  link:
  - description: Paper to which the dataset corresponds.
    relation: research_paper
    url: http.//doi.org/10.1021/jacs.5c09057
  record:
  - id: '20321'
    relation: research_data
    status: public
status: public
title: 'Dataset for "Bumps on the Road: The Way to Clean Relaxation Dispersion in
  the Solid State"'
tmp:
  image: /images/cc_by_nc_sa.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
    BY-NC-SA 4.0)
  short: CC BY-NC-SA (4.0)
type: research_data
user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '19699'
abstract:
- lang: eng
  text: We demonstrate that gas disks around binary systems might deliver gas to the
    binary components only when the circumbinary disk is relatively warm. We present
    new grid-based hydrodynamics simulations, performed with the binary on the grid
    and a locally isothermal equation of state, in which the binary is seen to functionally
    "stop accreting" if the orbital Mach number in the disk exceeds a threshold value
    of about 40. Above this threshold, the disk continues to extract angular momentum
    from the binary orbit, but it delivers very little mass to the black holes and
    instead piles up mass in a ring surrounding the binary. This ring will eventually
    become viscously relaxed and deliver mass to the binary at the large-scale inflow
    rate. However, we show that the timescale for such relaxation can far exceed the
    implied binary lifetime. We demonstrate that the ability of a binary–disk system
    to equilibrate is dependent on the efficiency at which accretion streams deposit
    mass onto the binary, which, in turn is highly sensitive to the thermodynamic
    conditions of the inner disk. If disks around massive black hole binaries do operate
    in such nonaccreting regimes, it suggests these systems may be dimmer than their
    single black hole counterparts but could exhibit dramatic rebrightening after
    the black holes inspiral and merge. This dimming begins in the UV/optical and
    could completely choke high-energy emission, such that these systems would likely
    be intrinsically X-ray weak with reddened continua, potentially resembling the
    spectra of "little red dots" recently identified in JWST observations.
acknowledgement: C.T. sincerely thanks Daniel J. D'Orazio for useful and illuminating
  discussions. This work was supported by the European Union's Horizon 2023 research
  and innovation program under Marie Sklodowska-Curie grant agreement No. 101148364,
  by Sapere Aude Starting grant No. 121587 through the Danish Independent Research
  Fund, by the LISA Preparatory Science Program (LPS) through NASA grant 80NSSC24K0440,
  and by NASA Astrophysics Theory Program (ATP) grant 80NSSC22K0822. Computation time
  for this work was supported through the NYU IT High Performance Computing resources
  as well as the Tycho supercomputer hosted at the SCIENCE HPC center at the University
  of Copenhagen.
article_number: '144'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Christopher
  full_name: Tiede, Christopher
  last_name: Tiede
- first_name: Jonathan
  full_name: Zrake, Jonathan
  last_name: Zrake
- first_name: Andrew
  full_name: Macfadyen, Andrew
  last_name: Macfadyen
- first_name: Zoltán
  full_name: Haiman, Zoltán
  id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
  last_name: Haiman
  orcid: 0000-0003-3633-5403
citation:
  ama: Tiede C, Zrake J, Macfadyen A, Haiman Z. Suppressed accretion onto massive
    black hole binaries surrounded by thin disks. <i>The Astrophysical Journal</i>.
    2025;984(2). doi:<a href="https://doi.org/10.3847/1538-4357/adc727">10.3847/1538-4357/adc727</a>
  apa: Tiede, C., Zrake, J., Macfadyen, A., &#38; Haiman, Z. (2025). Suppressed accretion
    onto massive black hole binaries surrounded by thin disks. <i>The Astrophysical
    Journal</i>. IOP Publishing. <a href="https://doi.org/10.3847/1538-4357/adc727">https://doi.org/10.3847/1538-4357/adc727</a>
  chicago: Tiede, Christopher, Jonathan Zrake, Andrew Macfadyen, and Zoltán Haiman.
    “Suppressed Accretion onto Massive Black Hole Binaries Surrounded by Thin Disks.”
    <i>The Astrophysical Journal</i>. IOP Publishing, 2025. <a href="https://doi.org/10.3847/1538-4357/adc727">https://doi.org/10.3847/1538-4357/adc727</a>.
  ieee: C. Tiede, J. Zrake, A. Macfadyen, and Z. Haiman, “Suppressed accretion onto
    massive black hole binaries surrounded by thin disks,” <i>The Astrophysical Journal</i>,
    vol. 984, no. 2. IOP Publishing, 2025.
  ista: Tiede C, Zrake J, Macfadyen A, Haiman Z. 2025. Suppressed accretion onto massive
    black hole binaries surrounded by thin disks. The Astrophysical Journal. 984(2),
    144.
  mla: Tiede, Christopher, et al. “Suppressed Accretion onto Massive Black Hole Binaries
    Surrounded by Thin Disks.” <i>The Astrophysical Journal</i>, vol. 984, no. 2,
    144, IOP Publishing, 2025, doi:<a href="https://doi.org/10.3847/1538-4357/adc727">10.3847/1538-4357/adc727</a>.
  short: C. Tiede, J. Zrake, A. Macfadyen, Z. Haiman, The Astrophysical Journal 984
    (2025).
date_created: 2025-05-18T22:02:49Z
date_published: 2025-05-09T00:00:00Z
date_updated: 2026-02-16T12:42:56Z
day: '09'
ddc:
- '520'
department:
- _id: ZoHa
doi: 10.3847/1538-4357/adc727
external_id:
  arxiv:
  - '2410.03830'
  isi:
  - '001483889000001'
file:
- access_level: open_access
  checksum: 0d4c57ee944599c0789f3db467c5ca2f
  content_type: application/pdf
  creator: dernst
  date_created: 2025-05-19T07:20:30Z
  date_updated: 2025-05-19T07:20:30Z
  file_id: '19708'
  file_name: 2025_AstrophysicalJour_Tiede.pdf
  file_size: 1058601
  relation: main_file
  success: 1
file_date_updated: 2025-05-19T07:20:30Z
fulldoi: https://doi.org/10.3847/1538-4357/adc727
has_accepted_license: '1'
intvolume: '       984'
isi: 1
issue: '2'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
  eissn:
  - 1538-4357
  issn:
  - 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Suppressed accretion onto massive black hole binaries surrounded by thin disks
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 984
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '19700'
abstract:
- lang: eng
  text: The JWST discovery of "little red dots" (LRDs) is reshaping our picture of
    the early Universe, yet the physical mechanisms driving their compact size and
    UV-optical colors remain elusive. Here, we report an unusually bright LRD (zspec
    = 3.1) observed as part of the RUBIES program. This LRD exhibits broad emission
    lines (FWHM ∼ 4000 km s−1), a blue UV continuum, a clear Balmer break, and a red
    continuum sampled out to rest-frame 4 μm with MIRI. We develop a new joint galaxy
    and active galactic nucleus (AGN) model within the Prospector Bayesian inference
    framework and perform spectrophotometric modeling using NIRCam, MIRI, and NIRSpec/Prism
    observations. Our fiducial model reveals a M* ∼ 109 M⊙ galaxy alongside a dust-reddened
    AGN driving the optical emission. Explaining the rest-frame optical color as a
    reddened AGN requires AV ≳ 3, suggesting that a great majority of the accretion
    disk energy is reradiated as dust emission. Yet, despite clear AGN signatures,
    we find a surprising lack of hot torus emission, which implies that either the
    dust emission in this object must be cold, or the red continuum must instead be
    driven by a massive, evolved stellar population of the host galaxy—seemingly inconsistent
    with the high-EW broad lines (Hα rest-frame EW ∼ 800 Å). The widths and luminosities
    of Pa-β, Pa-δ, Pa-γ, and Hα imply a modest black hole mass of MBH ∼ 108 M⊙. Additionally,
    we identify a narrow blueshifted He i λ 1.083 μm absorption feature in NIRSpec/G395M
    spectra, signaling an ionized outflow with kinetic energy up to ∼1% the luminosity
    of the AGN. The low redshift of RUBIES-BLAGN-1, combined with the depth and richness
    of the JWST imaging and spectroscopic observations, provides a unique opportunity
    to build a physical model for these so-far mysterious LRDs, which may prove to
    be a crucial phase in the early formation of massive galaxies and their supermassive
    black holes.
acknowledgement: 'B.W. and J.L. acknowledge support from JWST-GO-04233.009-A. R.L.D.
  is supported by the Australian Research Council through the Discovery Early Career
  Researcher Award (DECRA) Fellowship DE240100136 funded by the Australian Government.
  T.B.M. was supported by a CIERA postdoctoral fellowship. The Cosmic Dawn Center
  is funded by the Danish National Research Foundation (DNRF) under grant #140. This
  research was supported by the International Space Science Institute (ISSI) in Bern,
  through ISSI International Team project #562 (First Light at Cosmic Dawn: Exploiting
  the James Webb Space Telescope Revolution). The JWST data presented in this article
  were obtained from the Mikulski Archive for Space Telescopes (MAST) at the Space
  Telescope Science Institute. The specific observations analyzed here can be accessed
  via DOI:10.17909/c3t4-9p39. Computations for this research were performed on the
  Pennsylvania State University''s Institute for Computational and Data Sciences''
  Roar supercomputer. This publication made use of the NASA Astrophysical Data System
  for bibliographic information.'
article_number: '121'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Bingjie
  full_name: Wang, Bingjie
  last_name: Wang
- first_name: Anna
  full_name: De Graaff, Anna
  last_name: De Graaff
- first_name: Rebecca L.
  full_name: Davies, Rebecca L.
  last_name: Davies
- first_name: Jenny E.
  full_name: Greene, Jenny E.
  last_name: Greene
- first_name: Joel
  full_name: Leja, Joel
  last_name: Leja
- first_name: Gabriel B.
  full_name: Brammer, Gabriel B.
  last_name: Brammer
- first_name: Andy D.
  full_name: Goulding, Andy D.
  last_name: Goulding
- first_name: Tim B.
  full_name: Miller, Tim B.
  last_name: Miller
- first_name: Katherine A.
  full_name: Suess, Katherine A.
  last_name: Suess
- first_name: Andrea
  full_name: Weibel, Andrea
  last_name: Weibel
- first_name: Christina C.
  full_name: Williams, Christina C.
  last_name: Williams
- first_name: Rachel
  full_name: Bezanson, Rachel
  last_name: Bezanson
- first_name: Leindert A.
  full_name: Boogaard, Leindert A.
  last_name: Boogaard
- first_name: Nikko J.
  full_name: Cleri, Nikko J.
  last_name: Cleri
- first_name: Michaela
  full_name: Hirschmann, Michaela
  last_name: Hirschmann
- first_name: Harley
  full_name: Katz, Harley
  last_name: Katz
- first_name: Ivo
  full_name: Labbé, Ivo
  last_name: Labbé
- first_name: Michael V.
  full_name: Maseda, Michael V.
  last_name: Maseda
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
- first_name: Ian
  full_name: Mcconachie, Ian
  last_name: Mcconachie
- first_name: Rohan P.
  full_name: Naidu, Rohan P.
  last_name: Naidu
- first_name: Pascal A.
  full_name: Oesch, Pascal A.
  last_name: Oesch
- first_name: Hans Walter
  full_name: Rix, Hans Walter
  last_name: Rix
- first_name: David J.
  full_name: Setton, David J.
  last_name: Setton
- first_name: Katherine E.
  full_name: Whitaker, Katherine E.
  last_name: Whitaker
citation:
  ama: 'Wang B, De Graaff A, Davies RL, et al. RUBIES: JWST/NIRSpec confirmation of
    an infrared-luminous, broad-line Little Red Dot with an ionized outflow. <i>The
    Astrophysical Journal</i>. 2025;984(2). doi:<a href="https://doi.org/10.3847/1538-4357/adc1ca">10.3847/1538-4357/adc1ca</a>'
  apa: 'Wang, B., De Graaff, A., Davies, R. L., Greene, J. E., Leja, J., Brammer,
    G. B., … Whitaker, K. E. (2025). RUBIES: JWST/NIRSpec confirmation of an infrared-luminous,
    broad-line Little Red Dot with an ionized outflow. <i>The Astrophysical Journal</i>.
    IOP Publishing. <a href="https://doi.org/10.3847/1538-4357/adc1ca">https://doi.org/10.3847/1538-4357/adc1ca</a>'
  chicago: 'Wang, Bingjie, Anna De Graaff, Rebecca L. Davies, Jenny E. Greene, Joel
    Leja, Gabriel B. Brammer, Andy D. Goulding, et al. “RUBIES: JWST/NIRSpec Confirmation
    of an Infrared-Luminous, Broad-Line Little Red Dot with an Ionized Outflow.” <i>The
    Astrophysical Journal</i>. IOP Publishing, 2025. <a href="https://doi.org/10.3847/1538-4357/adc1ca">https://doi.org/10.3847/1538-4357/adc1ca</a>.'
  ieee: 'B. Wang <i>et al.</i>, “RUBIES: JWST/NIRSpec confirmation of an infrared-luminous,
    broad-line Little Red Dot with an ionized outflow,” <i>The Astrophysical Journal</i>,
    vol. 984, no. 2. IOP Publishing, 2025.'
  ista: 'Wang B, De Graaff A, Davies RL, Greene JE, Leja J, Brammer GB, Goulding AD,
    Miller TB, Suess KA, Weibel A, Williams CC, Bezanson R, Boogaard LA, Cleri NJ,
    Hirschmann M, Katz H, Labbé I, Maseda MV, Matthee JJ, Mcconachie I, Naidu RP,
    Oesch PA, Rix HW, Setton DJ, Whitaker KE. 2025. RUBIES: JWST/NIRSpec confirmation
    of an infrared-luminous, broad-line Little Red Dot with an ionized outflow. The
    Astrophysical Journal. 984(2), 121.'
  mla: 'Wang, Bingjie, et al. “RUBIES: JWST/NIRSpec Confirmation of an Infrared-Luminous,
    Broad-Line Little Red Dot with an Ionized Outflow.” <i>The Astrophysical Journal</i>,
    vol. 984, no. 2, 121, IOP Publishing, 2025, doi:<a href="https://doi.org/10.3847/1538-4357/adc1ca">10.3847/1538-4357/adc1ca</a>.'
  short: B. Wang, A. De Graaff, R.L. Davies, J.E. Greene, J. Leja, G.B. Brammer, A.D.
    Goulding, T.B. Miller, K.A. Suess, A. Weibel, C.C. Williams, R. Bezanson, L.A.
    Boogaard, N.J. Cleri, M. Hirschmann, H. Katz, I. Labbé, M.V. Maseda, J.J. Matthee,
    I. Mcconachie, R.P. Naidu, P.A. Oesch, H.W. Rix, D.J. Setton, K.E. Whitaker, The
    Astrophysical Journal 984 (2025).
date_created: 2025-05-18T22:02:49Z
date_published: 2025-05-09T00:00:00Z
date_updated: 2026-02-16T12:42:43Z
day: '09'
ddc:
- '520'
department:
- _id: JoMa
doi: 10.3847/1538-4357/adc1ca
external_id:
  arxiv:
  - '2403.02304'
  isi:
  - '001481589300001'
file:
- access_level: open_access
  checksum: 1a9ff4516d11808bc6947744473c9fc2
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  creator: dernst
  date_created: 2025-05-19T07:08:39Z
  date_updated: 2025-05-19T07:08:39Z
  file_id: '19707'
  file_name: 2025_AstrophysicalJour_Wang.pdf
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  relation: main_file
  success: 1
file_date_updated: 2025-05-19T07:08:39Z
fulldoi: https://doi.org/10.3847/1538-4357/adc1ca
has_accepted_license: '1'
intvolume: '       984'
isi: 1
issue: '2'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
  eissn:
  - 1538-4357
  issn:
  - 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'RUBIES: JWST/NIRSpec confirmation of an infrared-luminous, broad-line Little
  Red Dot with an ionized outflow'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 984
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '19702'
abstract:
- lang: eng
  text: Moran Birth-death process is a standard stochastic process that is used to
    model natural selection in spatially structured populations. A newly occurring
    mutation that invades a population of residents can either fixate on the whole
    population or it can go extinct due to random drift. The duration of the process
    depends not only on the total population size n, but also on the spatial structure
    of the population. In this work, we consider the Moran process with a single type
    of individuals who invade and colonize an otherwise empty environment. Mathematically,
    this corresponds to the setting where the residents have zero reproduction rate,
    thus they never reproduce. The spatial structure is represented by a graph. We
    present two main contributions. First, in contrast to the Moran process in which
    residents do reproduce, we show that the colonization time is always at most a
    polynomial function of the population size n. Namely, we show that colonization
    always takes at most 1/2n^3 - 1/2n^2 expected steps, and for each n, we identify
    the slowest graph where it takes exactly that many steps. Moreover, we establish
    a stronger bound of roughly n^2.5 steps for undirected graphs and an even stronger
    bound of roughly n^2 steps for so-called regular graphs. Second, we discuss various
    complications that one faces when attempting to measure fixation times and colonization
    times in spatially structured populations, and we propose to measure the real
    duration of the process, rather than counting the steps of the classic Moran process.
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Lenka
  full_name: Kopfová, Lenka
  id: 17691681-50b9-11ef-ad56-edf4cacb21b0
  last_name: Kopfová
- first_name: Josef
  full_name: Tkadlec, Josef
  id: 3F24CCC8-F248-11E8-B48F-1D18A9856A87
  last_name: Tkadlec
  orcid: 0000-0002-1097-9684
citation:
  ama: Kopfová L, Tkadlec J. Colonization times in Moran process on graphs. <i>PLoS
    computational biology</i>. 2025;21(5):e1012868. doi:<a href="https://doi.org/10.1371/journal.pcbi.1012868">10.1371/journal.pcbi.1012868</a>
  apa: Kopfová, L., &#38; Tkadlec, J. (2025). Colonization times in Moran process
    on graphs. <i>PLoS Computational Biology</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pcbi.1012868">https://doi.org/10.1371/journal.pcbi.1012868</a>
  chicago: Kopfová, Lenka, and Josef Tkadlec. “Colonization Times in Moran Process
    on Graphs.” <i>PLoS Computational Biology</i>. Public Library of Science, 2025.
    <a href="https://doi.org/10.1371/journal.pcbi.1012868">https://doi.org/10.1371/journal.pcbi.1012868</a>.
  ieee: L. Kopfová and J. Tkadlec, “Colonization times in Moran process on graphs,”
    <i>PLoS computational biology</i>, vol. 21, no. 5. Public Library of Science,
    p. e1012868, 2025.
  ista: Kopfová L, Tkadlec J. 2025. Colonization times in Moran process on graphs.
    PLoS computational biology. 21(5), e1012868.
  mla: Kopfová, Lenka, and Josef Tkadlec. “Colonization Times in Moran Process on
    Graphs.” <i>PLoS Computational Biology</i>, vol. 21, no. 5, Public Library of
    Science, 2025, p. e1012868, doi:<a href="https://doi.org/10.1371/journal.pcbi.1012868">10.1371/journal.pcbi.1012868</a>.
  short: L. Kopfová, J. Tkadlec, PLoS Computational Biology 21 (2025) e1012868.
date_created: 2025-05-18T22:02:50Z
date_published: 2025-05-01T00:00:00Z
date_updated: 2025-09-30T12:34:03Z
day: '01'
ddc:
- '000'
department:
- _id: GradSch
doi: 10.1371/journal.pcbi.1012868
external_id:
  arxiv:
  - '2410.09476'
  isi:
  - '001481670600002'
file:
- access_level: open_access
  checksum: 73e35151eebd5064972c5a07ffdf2b69
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  creator: dernst
  date_created: 2025-05-19T07:45:31Z
  date_updated: 2025-05-19T07:45:31Z
  file_id: '19709'
  file_name: 2025_PloSCompBio_Kopfova.pdf
  file_size: 6805943
  relation: main_file
  success: 1
file_date_updated: 2025-05-19T07:45:31Z
fulldoi: https://doi.org/10.1371/journal.pcbi.1012868
has_accepted_license: '1'
intvolume: '        21'
isi: 1
issue: '5'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: e1012868
publication: PLoS computational biology
publication_identifier:
  eissn:
  - 1553-7358
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Colonization times in Moran process on graphs
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 21
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '19703'
abstract:
- lang: eng
  text: An enlarged brain underlies the complex central nervous system of vertebrates.
    The dramatic expansion of the brain that diverges its shape from the spinal cord
    follows neural tube closure during embryonic development. Here, we show that this
    differential deformation is encoded by a pre-pattern of tissue material properties
    in chicken embryos. Using magnetic droplets and atomic force microscopy, we demonstrate
    that the dorsal hindbrain is more fluid than the dorsal spinal cord, resulting
    in a thinning versus a resisting response to increasing lumen pressure, respectively.
    The dorsal hindbrain exhibits reduced apical actin and a disorganized laminin
    matrix consistent with tissue fluidization. Blocking the activity of neural-crest-associated
    matrix metalloproteinases inhibits hindbrain expansion. Transplanting dorsal hindbrain
    cells to the spinal cord can locally create an expanded brain-like morphology
    in some cases. Our findings raise questions in vertebrate head evolution and suggest
    a general role of mechanical pre-patterning in sculpting epithelial tubes.
acknowledgement: 'We thank A. Dimitracopoulos, K. Kawaguchi, J. Vidigueira, B. Baum,
  I. McLaren, D. St Johnston, and members of the Buckley, Scarpa, Steventon, Kawaguchi,
  and Xiong labs for technical assistance and constructive feedback. We thank Ryan
  Greenhalgh for methods developed to obtain fluidity values from AFM data. We thank
  Nicola Lawrence, Alex Sossick, and Sargon Gross-Thebing from the Gurdon Institute
  Imaging Facility for microscopy support. Funding: this work was supported by a Wellcome
  Trust/Royal Society Sir Henry Dale Fellowship (215439/Z/19/Z) and UKRI-EPSRC Frontier
  Research Grant (EP/X023761/1, originally selected as an ERC Starting Grant) to F.X.;
  an ERC Consolidator Grant (772426), ERC Synergy Grant 101118729 UNFOLD, and Alexander
  von Humboldt Professorship ( Alexander von Humboldt Foundation) to K.F.; and an
  ERC Starting Grant (851288) to E.H.'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Susannah B.P.
  full_name: Mclaren, Susannah B.P.
  last_name: Mclaren
- first_name: Shi-lei
  full_name: Xue, Shi-lei
  id: 31D2C804-F248-11E8-B48F-1D18A9856A87
  last_name: Xue
- first_name: Siyuan
  full_name: Ding, Siyuan
  last_name: Ding
- first_name: Alexander K.
  full_name: Winkel, Alexander K.
  last_name: Winkel
- first_name: Oscar
  full_name: Baldwin, Oscar
  last_name: Baldwin
- first_name: Shreya
  full_name: Dwarakacherla, Shreya
  last_name: Dwarakacherla
- first_name: Kristian
  full_name: Franze, Kristian
  last_name: Franze
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Fengzhu
  full_name: Xiong, Fengzhu
  last_name: Xiong
citation:
  ama: Mclaren SBP, Xue S, Ding S, et al. Differential tissue deformability underlies
    fluid pressure-driven shape divergence of the avian embryonic brain and spinal
    cord. <i>Developmental Cell</i>. 2025;60(17):2237-2247.e4. doi:<a href="https://doi.org/10.1016/j.devcel.2025.04.010">10.1016/j.devcel.2025.04.010</a>
  apa: Mclaren, S. B. P., Xue, S., Ding, S., Winkel, A. K., Baldwin, O., Dwarakacherla,
    S., … Xiong, F. (2025). Differential tissue deformability underlies fluid pressure-driven
    shape divergence of the avian embryonic brain and spinal cord. <i>Developmental
    Cell</i>. Elsevier. <a href="https://doi.org/10.1016/j.devcel.2025.04.010">https://doi.org/10.1016/j.devcel.2025.04.010</a>
  chicago: Mclaren, Susannah B.P., Shi-lei Xue, Siyuan Ding, Alexander K. Winkel,
    Oscar Baldwin, Shreya Dwarakacherla, Kristian Franze, Edouard B Hannezo, and Fengzhu
    Xiong. “Differential Tissue Deformability Underlies Fluid Pressure-Driven Shape
    Divergence of the Avian Embryonic Brain and Spinal Cord.” <i>Developmental Cell</i>.
    Elsevier, 2025. <a href="https://doi.org/10.1016/j.devcel.2025.04.010">https://doi.org/10.1016/j.devcel.2025.04.010</a>.
  ieee: S. B. P. Mclaren <i>et al.</i>, “Differential tissue deformability underlies
    fluid pressure-driven shape divergence of the avian embryonic brain and spinal
    cord,” <i>Developmental Cell</i>, vol. 60, no. 17. Elsevier, p. 2237–2247.e4,
    2025.
  ista: Mclaren SBP, Xue S, Ding S, Winkel AK, Baldwin O, Dwarakacherla S, Franze
    K, Hannezo EB, Xiong F. 2025. Differential tissue deformability underlies fluid
    pressure-driven shape divergence of the avian embryonic brain and spinal cord.
    Developmental Cell. 60(17), 2237–2247.e4.
  mla: Mclaren, Susannah B. P., et al. “Differential Tissue Deformability Underlies
    Fluid Pressure-Driven Shape Divergence of the Avian Embryonic Brain and Spinal
    Cord.” <i>Developmental Cell</i>, vol. 60, no. 17, Elsevier, 2025, p. 2237–2247.e4,
    doi:<a href="https://doi.org/10.1016/j.devcel.2025.04.010">10.1016/j.devcel.2025.04.010</a>.
  short: S.B.P. Mclaren, S. Xue, S. Ding, A.K. Winkel, O. Baldwin, S. Dwarakacherla,
    K. Franze, E.B. Hannezo, F. Xiong, Developmental Cell 60 (2025) 2237–2247.e4.
date_created: 2025-05-18T22:02:50Z
date_published: 2025-09-08T00:00:00Z
date_updated: 2025-12-29T14:58:14Z
day: '08'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1016/j.devcel.2025.04.010
ec_funded: 1
external_id:
  isi:
  - '001570502100005'
  pmid:
  - '40347948'
file:
- access_level: open_access
  checksum: 1ca6f0822c1cbd430686d5e2a4f96401
  content_type: application/pdf
  creator: dernst
  date_created: 2025-12-29T13:45:05Z
  date_updated: 2025-12-29T13:45:05Z
  file_id: '20872'
  file_name: 2025_DevelopmentalCell_McLaren.pdf
  file_size: 12564806
  relation: main_file
  success: 1
file_date_updated: 2025-12-29T13:45:05Z
fulldoi: https://doi.org/10.1016/j.devcel.2025.04.010
has_accepted_license: '1'
intvolume: '        60'
isi: 1
issue: '17'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 2237-2247.e4
pmid: 1
project:
- _id: 05943252-7A3F-11EA-A408-12923DDC885E
  call_identifier: H2020
  grant_number: '851288'
  name: Design Principles of Branching Morphogenesis
publication: Developmental Cell
publication_identifier:
  eissn:
  - 1878-1551
  issn:
  - 1534-5807
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential tissue deformability underlies fluid pressure-driven shape divergence
  of the avian embryonic brain and spinal cord
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 60
year: '2025'
...
---
APC_amount: 2320,48 EUR
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '19705'
abstract:
- lang: eng
  text: A maximal realization of the two-dimensional Pauli operator, subject to Aharonov–Bohm
    magnetic field, is investigated. Contrary to the case of the Pauli operator with
    regular magnetic potentials, it is shown that both components of the Pauli operator
    are critical. Asymptotics of the weakly coupled eigenvalues, generated by electric
    (not necessarily self-adjoint) perturbations, are derived.
acknowledgement: Thanks belong to Johannes Ageskov and Matˇej Tuˇsek for helpful discussions
  on some technical details. M. F. would further like to acknowledge support for research
  on this paper from the European Unions Horizon 2020 research and innovation programme
  under the Marie Sklodowska-Curie Grant Agreement No. 101034413 as well as support
  by funding from Villum Fonden through the QMATH Centreof Excellence Grant No. 10059.
  D. K. was supported by the EXPRO Grant No.20-17749X of the Czech Science Foundation
  (GACR).
article_number: '2550011'
article_processing_charge: Yes (in subscription journal)
article_type: original
arxiv: 1
author:
- first_name: Marie
  full_name: Fialova, Marie
  id: e9c9844d-9e21-11ec-b482-f96fc09f7c4d
  last_name: Fialova
- first_name: David
  full_name: Krejčiřík, David
  last_name: Krejčiřík
citation:
  ama: Fialova M, Krejčiřík D. Virtual bound states of the Pauli operator with an
    Aharonov–Bohm potential. <i>Reviews in Mathematical Physics</i>. 2025;37(6). doi:<a
    href="https://doi.org/10.1142/S0129055X25500114">10.1142/S0129055X25500114</a>
  apa: Fialova, M., &#38; Krejčiřík, D. (2025). Virtual bound states of the Pauli
    operator with an Aharonov–Bohm potential. <i>Reviews in Mathematical Physics</i>.
    World Scientific Publishing. <a href="https://doi.org/10.1142/S0129055X25500114">https://doi.org/10.1142/S0129055X25500114</a>
  chicago: Fialova, Marie, and David Krejčiřík. “Virtual Bound States of the Pauli
    Operator with an Aharonov–Bohm Potential.” <i>Reviews in Mathematical Physics</i>.
    World Scientific Publishing, 2025. <a href="https://doi.org/10.1142/S0129055X25500114">https://doi.org/10.1142/S0129055X25500114</a>.
  ieee: M. Fialova and D. Krejčiřík, “Virtual bound states of the Pauli operator with
    an Aharonov–Bohm potential,” <i>Reviews in Mathematical Physics</i>, vol. 37,
    no. 6. World Scientific Publishing, 2025.
  ista: Fialova M, Krejčiřík D. 2025. Virtual bound states of the Pauli operator with
    an Aharonov–Bohm potential. Reviews in Mathematical Physics. 37(6), 2550011.
  mla: Fialova, Marie, and David Krejčiřík. “Virtual Bound States of the Pauli Operator
    with an Aharonov–Bohm Potential.” <i>Reviews in Mathematical Physics</i>, vol.
    37, no. 6, 2550011, World Scientific Publishing, 2025, doi:<a href="https://doi.org/10.1142/S0129055X25500114">10.1142/S0129055X25500114</a>.
  short: M. Fialova, D. Krejčiřík, Reviews in Mathematical Physics 37 (2025).
date_created: 2025-05-18T22:02:51Z
date_published: 2025-07-01T00:00:00Z
date_updated: 2026-05-06T13:03:25Z
day: '01'
ddc:
- '530'
- '510'
department:
- _id: RoSe
doi: 10.1142/S0129055X25500114
ec_funded: 1
external_id:
  arxiv:
  - '2501.17029'
  isi:
  - '001481012500001'
file:
- access_level: open_access
  checksum: 559d97ee2da28bf0bd2c6af507f3a914
  content_type: application/pdf
  creator: dernst
  date_created: 2025-12-30T08:23:12Z
  date_updated: 2025-12-30T08:23:12Z
  file_id: '20893'
  file_name: 2025_ReviewsMathPhysics_Fialova.pdf
  file_size: 484646
  relation: main_file
  success: 1
file_date_updated: 2025-12-30T08:23:12Z
fulldoi: https://doi.org/10.1142/S0129055X25500114
has_accepted_license: '1'
intvolume: '        37'
isi: 1
issue: '6'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
publication: Reviews in Mathematical Physics
publication_identifier:
  eissn:
  - 1793-6659
  issn:
  - 0129-055X
publication_status: published
publisher: World Scientific Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Virtual bound states of the Pauli operator with an Aharonov–Bohm potential
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 37
year: '2025'
...
---
OA_place: repository
OA_type: green
_id: '19712'
abstract:
- lang: eng
  text: "We study recent algebraic attacks (Briaud-Øygarden EC’23) on the Regular
    Syndrome Decoding (RSD) problem and the assumptions underlying the correctness
    of their attacks’ complexity estimates. By relating these assumptions to interesting
    algebraic-combinatorial problems, we prove that they do not hold in full generality.
    However, we show that they are (asymptotically) true for most parameter sets,
    supporting the soundness of algebraic attacks on RSD. Further, we prove—without
    any heuristics or assumptions—that RSD can be broken in polynomial time whenever
    the number of error blocks times the square of the size of error blocks is larger
    than 2 times the square of the dimension of the code.\r\nAdditionally, we use
    our methodology to attack a variant of the Learning With Errors problem where
    each error term lies in a fixed set of constant size. We prove that this problem
    can be broken in polynomial time, given a sufficient number of samples. This result
    improves on the seminal work by Arora and Ge (ICALP’11), as the attack’s time
    complexity is independent of the LWE modulus."
acknowledgement: We thank Pierre Briaud and Morten Øygarden for helpful discussions
  on algebraic attacks on RSD, and the EC reviewers for helpful comments.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Miguel
  full_name: Cueto Noval, Miguel
  id: ffc563a3-f6e0-11ea-865d-e3cce03d17cc
  last_name: Cueto Noval
  orcid: 0000-0002-2505-4246
- first_name: Simon-Philipp
  full_name: Merz, Simon-Philipp
  last_name: Merz
- first_name: Patrick
  full_name: Stählin, Patrick
  last_name: Stählin
- first_name: Akin
  full_name: Ünal, Akin
  id: f6b56fb6-dc63-11ee-9dbf-f6780863a85a
  last_name: Ünal
  orcid: 0000-0002-8929-0221
citation:
  ama: 'Cueto Noval M, Merz S-P, Stählin P, Ünal A. On the soundness of algebraic
    attacks against code-based assumptions. In: <i>44th Annual International Conference
    on the Theory and Applications of Cryptographic Techniques</i>. Vol 15606. Springer
    Nature; 2025:385-415. doi:<a href="https://doi.org/10.1007/978-3-031-91095-1_14">10.1007/978-3-031-91095-1_14</a>'
  apa: 'Cueto Noval, M., Merz, S.-P., Stählin, P., &#38; Ünal, A. (2025). On the soundness
    of algebraic attacks against code-based assumptions. In <i>44th Annual International
    Conference on the Theory and Applications of Cryptographic Techniques</i> (Vol.
    15606, pp. 385–415). Madrid, Spain: Springer Nature. <a href="https://doi.org/10.1007/978-3-031-91095-1_14">https://doi.org/10.1007/978-3-031-91095-1_14</a>'
  chicago: Cueto Noval, Miguel, Simon-Philipp Merz, Patrick Stählin, and Akin Ünal.
    “On the Soundness of Algebraic Attacks against Code-Based Assumptions.” In <i>44th
    Annual International Conference on the Theory and Applications of Cryptographic
    Techniques</i>, 15606:385–415. Springer Nature, 2025. <a href="https://doi.org/10.1007/978-3-031-91095-1_14">https://doi.org/10.1007/978-3-031-91095-1_14</a>.
  ieee: M. Cueto Noval, S.-P. Merz, P. Stählin, and A. Ünal, “On the soundness of algebraic
    attacks against code-based assumptions,” in <i>44th Annual International Conference
    on the Theory and Applications of Cryptographic Techniques</i>, Madrid, Spain,
    2025, vol. 15606, pp. 385–415.
  ista: 'Cueto Noval M, Merz S-P, Stählin P, Ünal A. 2025. On the soundness of algebraic
    attacks against code-based assumptions. 44th Annual International Conference on
    the Theory and Applications of Cryptographic Techniques. EUROCRYPT: International
    Conference on the Theory and Applications of Cryptographic Techniques, LNCS, vol.
    15606, 385–415.'
  mla: Cueto Noval, Miguel, et al. “On the Soundness of Algebraic Attacks against
    Code-Based Assumptions.” <i>44th Annual International Conference on the Theory
    and Applications of Cryptographic Techniques</i>, vol. 15606, Springer Nature,
    2025, pp. 385–415, doi:<a href="https://doi.org/10.1007/978-3-031-91095-1_14">10.1007/978-3-031-91095-1_14</a>.
  short: M. Cueto Noval, S.-P. Merz, P. Stählin, A. Ünal, in:, 44th Annual International
    Conference on the Theory and Applications of Cryptographic Techniques, Springer
    Nature, 2025, pp. 385–415.
conference:
  end_date: 2025-05-08
  location: Madrid, Spain
  name: 'EUROCRYPT: International Conference on the Theory and Applications of Cryptographic
    Techniques'
  start_date: 2025-05-04
corr_author: '1'
date_created: 2025-05-19T14:15:01Z
date_published: 2025-04-28T00:00:00Z
date_updated: 2025-05-28T06:12:39Z
day: '28'
department:
- _id: KrPi
doi: 10.1007/978-3-031-91095-1_14
fulldoi: https://doi.org/10.1007/978-3-031-91095-1_14
intvolume: '     15606'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.research-collection.ethz.ch/handle/20.500.11850/732894
month: '04'
oa: 1
oa_version: Submitted Version
page: 385-415
publication: 44th Annual International Conference on the Theory and Applications of
  Cryptographic Techniques
publication_identifier:
  eisbn:
  - '9783031910951'
  eissn:
  - 1611-3349
  isbn:
  - '9783031910944'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the soundness of algebraic attacks against code-based assumptions
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15606
year: '2025'
...
---
OA_place: publisher
OA_type: free access
_id: '19713'
abstract:
- lang: eng
  text: Distributed optimization is the standard way of speeding up machine learning
    training, and most of the research in the area focuses on distributed first-order,
    gradient-based methods. Yet, there are settings where some computationally-bounded
    nodes may not be able to implement first-order, gradient-based optimization, while
    they could still contribute to joint optimization tasks. In this paper, we initiate
    the study of hybrid decentralized optimization, studying settings where nodes
    with zeroth-order and first-order optimization capabilities co-exist in a distributed
    system, and attempt to jointly solve an optimization task over some data distribution.
    We essentially show that, under reasonable parameter settings, such a system can
    not only withstand noisier zeroth-order agents but can even benefit from integrating
    such agents into the optimization process, rather than ignoring their information.
    At the core of our approach is a new analysis of distributed optimization with
    noisy and possibly-biased gradient estimators, which may be of independent interest.
    Our results hold for both convex and non-convex objectives. Experimental results
    on standard optimization tasks confirm our analysis, showing that hybrid first-zeroth
    order optimization can be practical, even when training deep neural networks.
acknowledgement: "This project has received funding from the European Research Council
  (ERC) under the European Union’s Horizon 2020 research and innovation programme
  (grant agreement\r\nNo 805223 ScaleML). The authors would like to acknowledge Eugenia
  Iofinova for useful discussions during the inception of this project."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Shayan
  full_name: Talaei, Shayan
  last_name: Talaei
- first_name: Matin
  full_name: Ansaripour, Matin
  last_name: Ansaripour
- first_name: Giorgi
  full_name: Nadiradze, Giorgi
  id: 3279A00C-F248-11E8-B48F-1D18A9856A87
  last_name: Nadiradze
  orcid: 0000-0001-5634-0731
- first_name: Dan-Adrian
  full_name: Alistarh, Dan-Adrian
  id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
  last_name: Alistarh
  orcid: 0000-0003-3650-940X
citation:
  ama: 'Talaei S, Ansaripour M, Nadiradze G, Alistarh D-A. Hybrid decentralized optimization:
    Leveraging both first- and zeroth-order optimizers for faster convergence. <i>Proceedings
    of the 39th AAAI Conference on Artificial Intelligence</i>. 2025;39(19):20778-20786.
    doi:<a href="https://doi.org/10.1609/aaai.v39i19.34290">10.1609/aaai.v39i19.34290</a>'
  apa: 'Talaei, S., Ansaripour, M., Nadiradze, G., &#38; Alistarh, D.-A. (2025). Hybrid
    decentralized optimization: Leveraging both first- and zeroth-order optimizers
    for faster convergence. <i>Proceedings of the 39th AAAI Conference on Artificial
    Intelligence</i>. Association for the Advancement of Artificial Intelligence.
    <a href="https://doi.org/10.1609/aaai.v39i19.34290">https://doi.org/10.1609/aaai.v39i19.34290</a>'
  chicago: 'Talaei, Shayan, Matin Ansaripour, Giorgi Nadiradze, and Dan-Adrian Alistarh.
    “Hybrid Decentralized Optimization: Leveraging Both First- and Zeroth-Order Optimizers
    for Faster Convergence.” <i>Proceedings of the 39th AAAI Conference on Artificial
    Intelligence</i>. Association for the Advancement of Artificial Intelligence,
    2025. <a href="https://doi.org/10.1609/aaai.v39i19.34290">https://doi.org/10.1609/aaai.v39i19.34290</a>.'
  ieee: 'S. Talaei, M. Ansaripour, G. Nadiradze, and D.-A. Alistarh, “Hybrid decentralized
    optimization: Leveraging both first- and zeroth-order optimizers for faster convergence,”
    <i>Proceedings of the 39th AAAI Conference on Artificial Intelligence</i>, vol.
    39, no. 19. Association for the Advancement of Artificial Intelligence, pp. 20778–20786,
    2025.'
  ista: 'Talaei S, Ansaripour M, Nadiradze G, Alistarh D-A. 2025. Hybrid decentralized
    optimization: Leveraging both first- and zeroth-order optimizers for faster convergence.
    Proceedings of the 39th AAAI Conference on Artificial Intelligence. 39(19), 20778–20786.'
  mla: 'Talaei, Shayan, et al. “Hybrid Decentralized Optimization: Leveraging Both
    First- and Zeroth-Order Optimizers for Faster Convergence.” <i>Proceedings of
    the 39th AAAI Conference on Artificial Intelligence</i>, vol. 39, no. 19, Association
    for the Advancement of Artificial Intelligence, 2025, pp. 20778–86, doi:<a href="https://doi.org/10.1609/aaai.v39i19.34290">10.1609/aaai.v39i19.34290</a>.'
  short: S. Talaei, M. Ansaripour, G. Nadiradze, D.-A. Alistarh, Proceedings of the
    39th AAAI Conference on Artificial Intelligence 39 (2025) 20778–20786.
corr_author: '1'
date_created: 2025-05-19T14:15:35Z
date_published: 2025-04-11T00:00:00Z
date_updated: 2026-02-16T12:34:44Z
day: '11'
department:
- _id: DaAl
doi: 10.1609/aaai.v39i19.34290
ec_funded: 1
external_id:
  arxiv:
  - '2210.07703'
fulldoi: https://doi.org/10.1609/aaai.v39i19.34290
intvolume: '        39'
issue: '19'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1609/aaai.v39i19.34290
month: '04'
oa: 1
oa_version: Preprint
page: 20778-20786
project:
- _id: 268A44D6-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '805223'
  name: Elastic Coordination for Scalable Machine Learning
publication: Proceedings of the 39th AAAI Conference on Artificial Intelligence
publication_identifier:
  eissn:
  - 2374-3468
  issn:
  - 2159-5399
publication_status: published
publisher: Association for the Advancement of Artificial Intelligence
quality_controlled: '1'
related_material:
  link:
  - relation: software
    url: https://github.com/ShayanTalaei/HDO
scopus_import: '1'
status: public
title: 'Hybrid decentralized optimization: Leveraging both first- and zeroth-order
  optimizers for faster convergence'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 39
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '19718'
abstract:
- lang: eng
  text: The cerebral cortex is arguably the most complex organ in humans. The cortical
    architecture is characterized by a remarkable diversity of neuronal and glial
    cell types that make up its neuronal circuits. Following a precise temporally
    ordered program, radial glia progenitor (RGP) cells generate all cortical excitatory
    projection neurons and glial cell-types. Cortical excitatory projection neurons
    are produced either directly or via intermediate progenitors, through indirect
    neurogenesis. How the extensive cortical cell-type diversity is generated during
    cortex development remains, however, a fundamental open question. How do RGPs
    quantitatively and qualitatively generate all the neocortical neurons? How does
    direct and indirect neurogenesis contribute to the establishment of neuronal and
    lineage heterogeneity? Whether RGPs represent a homogeneous and/or multipotent
    progenitor population, or if RGPs consist of heterogeneous groups is currently
    also not known. In this review, we will summarize the latest findings that contributed
    to a deeper insight into the above key questions.
acknowledgement: We wish to thank all members of the Hippenmeyer laboratory at ISTA
  for exciting discussions on the subject of this review. We apologize to colleagues
  whose work we could not cite and/or discuss in the frame of the available space.
  Work in the Hippenmeyer laboratory on the discussed topic is supported by ISTA institutional
  funds, an EMBO LTF (ALTF 994–2023) to F.P, and FWF SFB F78 to S.H.
article_number: '103046'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Fabrizia
  full_name: Pipicelli, Fabrizia
  id: 649134fd-d012-11ed-8f82-db1e5050f9ba
  last_name: Pipicelli
- first_name: Ana
  full_name: Villalba Requena, Ana
  id: 68cb85a0-39f7-11eb-9559-9aaab4f6a247
  last_name: Villalba Requena
  orcid: 0000-0002-5615-5277
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
citation:
  ama: Pipicelli F, Villalba Requena A, Hippenmeyer S. How radial glia progenitor
    lineages generate cell-type diversity in the developing cerebral cortex. <i>Current
    Opinion in Neurobiology</i>. 2025;93. doi:<a href="https://doi.org/10.1016/j.conb.2025.103046">10.1016/j.conb.2025.103046</a>
  apa: Pipicelli, F., Villalba Requena, A., &#38; Hippenmeyer, S. (2025). How radial
    glia progenitor lineages generate cell-type diversity in the developing cerebral
    cortex. <i>Current Opinion in Neurobiology</i>. Elsevier. <a href="https://doi.org/10.1016/j.conb.2025.103046">https://doi.org/10.1016/j.conb.2025.103046</a>
  chicago: Pipicelli, Fabrizia, Ana Villalba Requena, and Simon Hippenmeyer. “How
    Radial Glia Progenitor Lineages Generate Cell-Type Diversity in the Developing
    Cerebral Cortex.” <i>Current Opinion in Neurobiology</i>. Elsevier, 2025. <a href="https://doi.org/10.1016/j.conb.2025.103046">https://doi.org/10.1016/j.conb.2025.103046</a>.
  ieee: F. Pipicelli, A. Villalba Requena, and S. Hippenmeyer, “How radial glia progenitor
    lineages generate cell-type diversity in the developing cerebral cortex,” <i>Current
    Opinion in Neurobiology</i>, vol. 93. Elsevier, 2025.
  ista: Pipicelli F, Villalba Requena A, Hippenmeyer S. 2025. How radial glia progenitor
    lineages generate cell-type diversity in the developing cerebral cortex. Current
    Opinion in Neurobiology. 93, 103046.
  mla: Pipicelli, Fabrizia, et al. “How Radial Glia Progenitor Lineages Generate Cell-Type
    Diversity in the Developing Cerebral Cortex.” <i>Current Opinion in Neurobiology</i>,
    vol. 93, 103046, Elsevier, 2025, doi:<a href="https://doi.org/10.1016/j.conb.2025.103046">10.1016/j.conb.2025.103046</a>.
  short: F. Pipicelli, A. Villalba Requena, S. Hippenmeyer, Current Opinion in Neurobiology
    93 (2025).
corr_author: '1'
date_created: 2025-05-20T10:20:09Z
date_published: 2025-08-01T00:00:00Z
date_updated: 2025-12-30T10:54:14Z
day: '01'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1016/j.conb.2025.103046
external_id:
  isi:
  - '001496227000001'
  pmid:
  - '40383049'
file:
- access_level: open_access
  checksum: 05bacb4acbe6275d43e873dec9ba1d52
  content_type: application/pdf
  creator: dernst
  date_created: 2025-12-30T08:25:49Z
  date_updated: 2025-12-30T08:25:49Z
  file_id: '20894'
  file_name: 2025_CurrentOpNeurobiology_Pipicelli.pdf
  file_size: 1592649
  relation: main_file
  success: 1
file_date_updated: 2025-12-30T08:25:49Z
fulldoi: https://doi.org/10.1016/j.conb.2025.103046
has_accepted_license: '1'
intvolume: '        93'
isi: 1
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 059F6AB4-7A3F-11EA-A408-12923DDC885E
  grant_number: F7805
  name: Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular
    Mechanisms of Neural Stem Cell Lineage Progression
- _id: 7c084566-9f16-11ee-852c-c88a1dbbf1cf
  grant_number: ALTF 994-2023
  name: Role of cell lineage in generating cell-type diversity in developing neocortex’
publication: Current Opinion in Neurobiology
publication_identifier:
  issn:
  - 0959-4388
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: How radial glia progenitor lineages generate cell-type diversity in the developing
  cerebral cortex
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 93
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '19725'
abstract:
- lang: eng
  text: Protein-protein interactions (PPIs) mediate many fundamental cellular processes.
    Control of PPIs through optically or chemically responsive protein domains has
    had a profound impact on basic research and some clinical applications. Most chemogenetic
    methods induce the association, i.e., dimerization or oligomerization, of target
    proteins, whilst the few available dissociation approaches either break large
    oligomeric protein clusters or heteromeric complexes. Here, we have exploited
    the controlled dissociation of a homodimeric oxidoreductase from mycobacteria
    (MSMEG_2027) by its native cofactor, F420, which is not present in mammals, as
    a bioorthogonal monomerization switch. Using X-ray crystallography, we found that
    in the absence of F420 MSMEG_2027 forms a unique domain-swapped dimer that occludes
    the cofactor binding site. Rearrangement of the N-terminal helix upon F420 binding
    results in the dissolution of the dimer. We then showed that MSMEG_2027 can be
    fused to proteins of interest in human cells and applied it as a tool to induce
    and release MAPK/ERK signalling downstream of a chimeric fibroblast growth factor
    receptor 1 (FGFR1) tyrosine kinase. This F420-dependent chemogenetic de-homodimerization
    tool is stoichiometric and based on a single domain and thus represents a novel
    mechanism to investigate protein complexes in situ.
acknowledgement: We thank J. Kaczmarski for advice on isothermal titration calorimetry
  and helpful comments, and Alexandra Tichy, Elliot Gerrard and Rahkesh T Sabapathy
  for assistance with experiments. This study was supported by grants of the Australian
  Research Council (FT200100519 and DP200102093, to H.J.; DE190100806, DP220101901,
  FT230100203, and DP250102939 to T.P.S.D.C; DP200102093, CE200100029 and CE200100012
  to C.J.J.), the National Health and Medical Research Council (APP1187638, to H.J.).
  S.K. was supported by the graduate program MolecularDrugTargets (Austrian Science
  Fund FWF W1232). The Australian Regenerative Medicine Institute is supported by
  grants from the State Government of Victoria and the Australian Government. The
  EMBL Australia Partnership Laboratory (EMBL Australia) is supported by the National
  Collaborative Research Infrastructure Strategy (NCRIS) of the Australian Government.
  T.P.S.D.C. acknowledges the University of Adelaide for a Future Making Fellowship.
  E.R.R.M acknowledges the Grains Research and Development Corporation (9176977) for
  support through a PhD scholarship and operational funding. J.A. and E.R.R.M. were
  supported by Australian Research Training Program scholarship. MicroMon of Monash
  University provided Sanger sequencing services. Imaging was performed in the CellScreen
  SA screening center of Flinders University. C.J.J. thanks the ARC Centre of Excellence
  for Innovations in Peptide and Protein Science and the ARC Centre of Excellence
  in Synthetic Biology. We thank the staff of the MX2 beamline at the Australian Synchrotron,
  part of ANSTO, which made use of the Australian Cancer Research Foundation (ACRF)
  detector.
article_number: '169184'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: James
  full_name: Antoney, James
  last_name: Antoney
- first_name: Stephanie
  full_name: Kainrath, Stephanie
  id: 32CFBA64-F248-11E8-B48F-1D18A9856A87
  last_name: Kainrath
  orcid: 0000-0002-6709-2195
- first_name: Joshua G.
  full_name: Dubowsky, Joshua G.
  last_name: Dubowsky
- first_name: F. Hafna
  full_name: Ahmed, F. Hafna
  last_name: Ahmed
- first_name: Suk Woo
  full_name: Kang, Suk Woo
  last_name: Kang
- first_name: Emily R.R.
  full_name: Mackie, Emily R.R.
  last_name: Mackie
- first_name: Gustavo
  full_name: Bracho Granado, Gustavo
  last_name: Bracho Granado
- first_name: Tatiana P.
  full_name: Soares Da Costa, Tatiana P.
  last_name: Soares Da Costa
- first_name: Colin J.
  full_name: Jackson, Colin J.
  last_name: Jackson
- first_name: Harald L
  full_name: Janovjak, Harald L
  id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
  last_name: Janovjak
  orcid: 0000-0002-8023-9315
citation:
  ama: Antoney J, Kainrath S, Dubowsky JG, et al. A F420-dependent single domain chemogenetic
    tool for protein de-dimerization. <i>Journal of Molecular Biology</i>. 2025;437(17).
    doi:<a href="https://doi.org/10.1016/j.jmb.2025.169184">10.1016/j.jmb.2025.169184</a>
  apa: Antoney, J., Kainrath, S., Dubowsky, J. G., Ahmed, F. H., Kang, S. W., Mackie,
    E. R. R., … Janovjak, H. L. (2025). A F420-dependent single domain chemogenetic
    tool for protein de-dimerization. <i>Journal of Molecular Biology</i>. Elsevier.
    <a href="https://doi.org/10.1016/j.jmb.2025.169184">https://doi.org/10.1016/j.jmb.2025.169184</a>
  chicago: Antoney, James, Stephanie Kainrath, Joshua G. Dubowsky, F. Hafna Ahmed,
    Suk Woo Kang, Emily R.R. Mackie, Gustavo Bracho Granado, Tatiana P. Soares Da
    Costa, Colin J. Jackson, and Harald L Janovjak. “A F420-Dependent Single Domain
    Chemogenetic Tool for Protein de-Dimerization.” <i>Journal of Molecular Biology</i>.
    Elsevier, 2025. <a href="https://doi.org/10.1016/j.jmb.2025.169184">https://doi.org/10.1016/j.jmb.2025.169184</a>.
  ieee: J. Antoney <i>et al.</i>, “A F420-dependent single domain chemogenetic tool
    for protein de-dimerization,” <i>Journal of Molecular Biology</i>, vol. 437, no.
    17. Elsevier, 2025.
  ista: Antoney J, Kainrath S, Dubowsky JG, Ahmed FH, Kang SW, Mackie ERR, Bracho
    Granado G, Soares Da Costa TP, Jackson CJ, Janovjak HL. 2025. A F420-dependent
    single domain chemogenetic tool for protein de-dimerization. Journal of Molecular
    Biology. 437(17), 169184.
  mla: Antoney, James, et al. “A F420-Dependent Single Domain Chemogenetic Tool for
    Protein de-Dimerization.” <i>Journal of Molecular Biology</i>, vol. 437, no. 17,
    169184, Elsevier, 2025, doi:<a href="https://doi.org/10.1016/j.jmb.2025.169184">10.1016/j.jmb.2025.169184</a>.
  short: J. Antoney, S. Kainrath, J.G. Dubowsky, F.H. Ahmed, S.W. Kang, E.R.R. Mackie,
    G. Bracho Granado, T.P. Soares Da Costa, C.J. Jackson, H.L. Janovjak, Journal
    of Molecular Biology 437 (2025).
date_created: 2025-05-25T22:16:39Z
date_published: 2025-09-01T00:00:00Z
date_updated: 2025-12-30T08:18:25Z
day: '01'
ddc:
- '570'
department:
- _id: CaGu
doi: 10.1016/j.jmb.2025.169184
external_id:
  isi:
  - '001494762800001'
  pmid:
  - '40324743'
file:
- access_level: open_access
  checksum: fb6e84ba7dc92faee97647fd2bc8cca8
  content_type: application/pdf
  creator: dernst
  date_created: 2025-12-30T08:18:07Z
  date_updated: 2025-12-30T08:18:07Z
  file_id: '20892'
  file_name: 2025_JourMolecularBiology_Antoney.pdf
  file_size: 1682721
  relation: main_file
  success: 1
file_date_updated: 2025-12-30T08:18:07Z
fulldoi: https://doi.org/10.1016/j.jmb.2025.169184
has_accepted_license: '1'
intvolume: '       437'
isi: 1
issue: '17'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 255A6082-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: W1232-B24
  name: Molecular Drug Targets
publication: Journal of Molecular Biology
publication_identifier:
  eissn:
  - 1089-8638
  issn:
  - 0022-2836
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: A F420-dependent single domain chemogenetic tool for protein de-dimerization
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 437
year: '2025'
...
---
OA_type: closed access
_id: '19726'
abstract:
- lang: eng
  text: The oxidation of biomass-derived compounds such as glucose within electrochemical
    cells enables both the energy-efficient production of hydrogen and the generation
    of additional added-value chemicals from biomass. However, for this biomass valorization
    approach to become commercially viable, selective, cost-effective, and highly
    active electrooxidation catalysts need to be developed. In this work, we detail
    the synthesis of a nickel (Ni) and zinc (Zn)-based electrocatalyst for the glucose
    oxidation reaction (GOR) to formic acid (FoA) via calcination of a Zn-based zeolitic
    imidazole framework (ZIF) functionalized with ethylenediamine and doped with Ni.
    The structure, morphology, and electrochemical performance of the catalysts towards
    the anodic GOR to FoA coupled with the cathodic hydrogen evolution reaction (HER)
    are subsequently studied. Chronopotentiometry tests with 0.1 M of glucose show
    a conversion of 94 % at 250 mA in only 70 min, with a Faradaic efficiency (FE)
    of 91 % toward the production of FoA. Meanwhile, at the cathode, the HER FE is
    close to 98 %.
acknowledgement: 'This work was financially supported by the SyDECat and AmaDE projects
  from the Spanish MCIN/AEI/FEDER (PID2022-136883OB-C22 & PID2023-149158OB-C43). The
  authors acknowledge funding from Generalitat de Catalunya 2021SGR01581, 2021SGR00457
  and European Union Next Generation EU/PRTR. KVMC acknowledges the grant from Call
  906 of 2021 for Doctorates Abroad from the Ministry of Science, Technology, and
  Innovation of Colombia. PRMA acknowledges support from the Ramón y Cajal grant RYC2023-042982-I,
  funded by MICIU/AEI (10.13039/501100011033) and co-financed by FSE+. This study
  is part of the Advanced Materials programme and was supported by MCIN with funding
  from European Union NextGenerationEU (PRTR-C17.I1) and by Generalitat de Catalunya
  (In-CAEM Project). ICN2 is supported by the Severo Ochoa program from Spanish MCIN
  / AEI (Grant No.: CEX2021-001214-S) and is funded by the CERCA Programme / Generalitat
  de Catalunya. ICN2 is founding member of e-DREAM. [76] J.L. is a Serra Húnter Fellow
  and is grateful to the ICREA Academia program and to projects PID2021-124572OB-C31
  and CEX2023-001300-M funded by MCIN/AEI/10.13039/501100011033, EU and FEDER, and
  to the GC 2021 SGR 01061 grant.'
article_number: '163491'
article_processing_charge: No
article_type: original
author:
- first_name: Karol V.
  full_name: Mejia-Centeno, Karol V.
  last_name: Mejia-Centeno
- first_name: Guillem
  full_name: Montaña-Mora, Guillem
  last_name: Montaña-Mora
- first_name: Jesús
  full_name: Chacón-Borrero, Jesús
  last_name: Chacón-Borrero
- first_name: Qian
  full_name: Xue, Qian
  last_name: Xue
- first_name: Li
  full_name: Gong, Li
  last_name: Gong
- first_name: Sara
  full_name: Martí-Sánchez, Sara
  last_name: Martí-Sánchez
- first_name: Armando
  full_name: Berlanga-Vázquez, Armando
  last_name: Berlanga-Vázquez
- first_name: Jordi
  full_name: Llorca, Jordi
  last_name: Llorca
- first_name: Maria
  full_name: Ibáñez, Maria
  id: 43C61214-F248-11E8-B48F-1D18A9856A87
  last_name: Ibáñez
  orcid: 0000-0001-5013-2843
- first_name: Jordi
  full_name: Arbiol, Jordi
  last_name: Arbiol
- first_name: Xueqiang
  full_name: Qi, Xueqiang
  last_name: Qi
- first_name: Paulina R.
  full_name: Martinez-Alanis, Paulina R.
  last_name: Martinez-Alanis
- first_name: Andreu
  full_name: Cabot, Andreu
  last_name: Cabot
citation:
  ama: Mejia-Centeno KV, Montaña-Mora G, Chacón-Borrero J, et al. Glucose electrooxidation
    with simultaneous H2 production on nickel-zinc electrocatalysts derived from an
    ethylenediamine-functionalized zeolitic imidazole framework. <i>Chemical Engineering
    Journal</i>. 2025;515. doi:<a href="https://doi.org/10.1016/j.cej.2025.163491">10.1016/j.cej.2025.163491</a>
  apa: Mejia-Centeno, K. V., Montaña-Mora, G., Chacón-Borrero, J., Xue, Q., Gong,
    L., Martí-Sánchez, S., … Cabot, A. (2025). Glucose electrooxidation with simultaneous
    H2 production on nickel-zinc electrocatalysts derived from an ethylenediamine-functionalized
    zeolitic imidazole framework. <i>Chemical Engineering Journal</i>. Elsevier. <a
    href="https://doi.org/10.1016/j.cej.2025.163491">https://doi.org/10.1016/j.cej.2025.163491</a>
  chicago: Mejia-Centeno, Karol V., Guillem Montaña-Mora, Jesús Chacón-Borrero, Qian
    Xue, Li Gong, Sara Martí-Sánchez, Armando Berlanga-Vázquez, et al. “Glucose Electrooxidation
    with Simultaneous H2 Production on Nickel-Zinc Electrocatalysts Derived from an
    Ethylenediamine-Functionalized Zeolitic Imidazole Framework.” <i>Chemical Engineering
    Journal</i>. Elsevier, 2025. <a href="https://doi.org/10.1016/j.cej.2025.163491">https://doi.org/10.1016/j.cej.2025.163491</a>.
  ieee: K. V. Mejia-Centeno <i>et al.</i>, “Glucose electrooxidation with simultaneous
    H2 production on nickel-zinc electrocatalysts derived from an ethylenediamine-functionalized
    zeolitic imidazole framework,” <i>Chemical Engineering Journal</i>, vol. 515.
    Elsevier, 2025.
  ista: Mejia-Centeno KV, Montaña-Mora G, Chacón-Borrero J, Xue Q, Gong L, Martí-Sánchez
    S, Berlanga-Vázquez A, Llorca J, Ibáñez M, Arbiol J, Qi X, Martinez-Alanis PR,
    Cabot A. 2025. Glucose electrooxidation with simultaneous H2 production on nickel-zinc
    electrocatalysts derived from an ethylenediamine-functionalized zeolitic imidazole
    framework. Chemical Engineering Journal. 515, 163491.
  mla: Mejia-Centeno, Karol V., et al. “Glucose Electrooxidation with Simultaneous
    H2 Production on Nickel-Zinc Electrocatalysts Derived from an Ethylenediamine-Functionalized
    Zeolitic Imidazole Framework.” <i>Chemical Engineering Journal</i>, vol. 515,
    163491, Elsevier, 2025, doi:<a href="https://doi.org/10.1016/j.cej.2025.163491">10.1016/j.cej.2025.163491</a>.
  short: K.V. Mejia-Centeno, G. Montaña-Mora, J. Chacón-Borrero, Q. Xue, L. Gong,
    S. Martí-Sánchez, A. Berlanga-Vázquez, J. Llorca, M. Ibáñez, J. Arbiol, X. Qi,
    P.R. Martinez-Alanis, A. Cabot, Chemical Engineering Journal 515 (2025).
date_created: 2025-05-25T22:16:40Z
date_published: 2025-07-01T00:00:00Z
date_updated: 2025-12-30T08:28:59Z
day: '01'
department:
- _id: MaIb
doi: 10.1016/j.cej.2025.163491
external_id:
  isi:
  - '001501928300003'
fulldoi: https://doi.org/10.1016/j.cej.2025.163491
intvolume: '       515'
isi: 1
language:
- iso: eng
month: '07'
oa_version: None
publication: Chemical Engineering Journal
publication_identifier:
  issn:
  - 1385-8947
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Glucose electrooxidation with simultaneous H2 production on nickel-zinc electrocatalysts
  derived from an ethylenediamine-functionalized zeolitic imidazole framework
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 515
year: '2025'
...
---
APC_amount: 5937,40 EUR
OA_place: publisher
OA_type: hybrid
_id: '19728'
abstract:
- lang: eng
  text: Root system integrates multiple environmental cues, chiefly gravity and soil
    humidity, to anchor plants in soil and forage for water. While the mechanism of
    auxin-mediated root gravitropism is comparably well-understood, the root’s capability
    to grow toward moist soil for water uptake and drought avoidance, termed root
    hydrotropism, remains largely mysterious. Here, we provide key insights into the
    mechanism of hydrotropic growth and assign a role to the master regulator of hydrotropism,
    MIZU-KUSSEI 1 (MIZ1). We show that efficient hydrotropism requires the attenuation
    of antagonistically acting gravitropism, which is inhibited under drought conditions.
    Drought stress interferes with subcellular trafficking and the lateral mobility
    of PIN auxin transporters, which are polarly localized at the root cell plasma
    membranes. This leads to defects in PIN2 polarity and gravity-induced polarization
    of PIN3, ultimately inhibiting gravity-induced auxin redistribution and root bending.
    The miz1 mutant is defective in all these regulations, and in support of MIZ1’s
    action on PINs, pin mutations rescue the hydrotropic defects in the miz1 mutant.
    These observations identify a mechanism for how drought via MIZ1 attenuates gravitropism
    to promote root hydrotropism for efficient water foraging under drought conditions.
acknowledgement: This work was supported by the European Union’s Horizon 2020 research
  and innovation Programme (European Research Council grant agreement number 742985),
  Austrian Science Fund (FWF, grant number I 3630-B25), (Institute of Science and
  Technology Austria) Fellow program, the Qin Chuangyuan High-level Innovation and
  Entrepreneurship Talent Program (QCYRCXM-2022-237), the Fundamental Research Funds
  for Northwest A&F University and partly supported by the open funds of the State
  Key Laboratory of Plant Environmental Resilience (SKLPERKF2416). We also thank the
  Teaching and Research Core Facility at the College of Life Sciences, Northwest A&F
  University, particularly Dr. Ningjuan Fan for technical assistance.
article_number: e2427315122
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Yuzhou
  full_name: Zhang, Yuzhou
  id: 3B6137F2-F248-11E8-B48F-1D18A9856A87
  last_name: Zhang
  orcid: 0000-0003-2627-6956
- first_name: Zhulatai
  full_name: Bao, Zhulatai
  last_name: Bao
- first_name: Adrijana
  full_name: Smoljan, Adrijana
  id: cced8a85-223e-11ed-af04-b0596c55053b
  last_name: Smoljan
- first_name: Yifan
  full_name: Liu, Yifan
  last_name: Liu
- first_name: Huihui
  full_name: Wang, Huihui
  last_name: Wang
- first_name: Jiří
  full_name: Friml, Jiří
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
citation:
  ama: Zhang Y, Bao Z, Smoljan A, Liu Y, Wang H, Friml J. Foraging for water by MIZ1-mediated
    antagonism between root gravitropism and hydrotropism. <i>Proceedings of the National
    Academy of Sciences</i>. 2025;122(20). doi:<a href="https://doi.org/10.1073/pnas.2427315122">10.1073/pnas.2427315122</a>
  apa: Zhang, Y., Bao, Z., Smoljan, A., Liu, Y., Wang, H., &#38; Friml, J. (2025).
    Foraging for water by MIZ1-mediated antagonism between root gravitropism and hydrotropism.
    <i>Proceedings of the National Academy of Sciences</i>. National Academy of Sciences.
    <a href="https://doi.org/10.1073/pnas.2427315122">https://doi.org/10.1073/pnas.2427315122</a>
  chicago: Zhang, Yuzhou, Zhulatai Bao, Adrijana Smoljan, Yifan Liu, Huihui Wang,
    and Jiří Friml. “Foraging for Water by MIZ1-Mediated Antagonism between Root Gravitropism
    and Hydrotropism.” <i>Proceedings of the National Academy of Sciences</i>. National
    Academy of Sciences, 2025. <a href="https://doi.org/10.1073/pnas.2427315122">https://doi.org/10.1073/pnas.2427315122</a>.
  ieee: Y. Zhang, Z. Bao, A. Smoljan, Y. Liu, H. Wang, and J. Friml, “Foraging for
    water by MIZ1-mediated antagonism between root gravitropism and hydrotropism,”
    <i>Proceedings of the National Academy of Sciences</i>, vol. 122, no. 20. National
    Academy of Sciences, 2025.
  ista: Zhang Y, Bao Z, Smoljan A, Liu Y, Wang H, Friml J. 2025. Foraging for water
    by MIZ1-mediated antagonism between root gravitropism and hydrotropism. Proceedings
    of the National Academy of Sciences. 122(20), e2427315122.
  mla: Zhang, Yuzhou, et al. “Foraging for Water by MIZ1-Mediated Antagonism between
    Root Gravitropism and Hydrotropism.” <i>Proceedings of the National Academy of
    Sciences</i>, vol. 122, no. 20, e2427315122, National Academy of Sciences, 2025,
    doi:<a href="https://doi.org/10.1073/pnas.2427315122">10.1073/pnas.2427315122</a>.
  short: Y. Zhang, Z. Bao, A. Smoljan, Y. Liu, H. Wang, J. Friml, Proceedings of the
    National Academy of Sciences 122 (2025).
corr_author: '1'
date_created: 2025-05-25T22:16:43Z
date_published: 2025-05-20T00:00:00Z
date_updated: 2026-05-20T08:34:21Z
day: '20'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1073/pnas.2427315122
ec_funded: 1
external_id:
  isi:
  - '001496347500001'
  pmid:
  - '40372432'
file:
- access_level: open_access
  checksum: f70ff35054561b27a463ba279d1795dc
  content_type: application/pdf
  creator: dernst
  date_created: 2025-05-28T08:04:50Z
  date_updated: 2025-05-28T08:04:50Z
  file_id: '19750'
  file_name: 2025_PNAS_Zhang.pdf
  file_size: 8266672
  relation: main_file
  success: 1
file_date_updated: 2025-05-28T08:04:50Z
fulldoi: https://doi.org/10.1073/pnas.2427315122
has_accepted_license: '1'
intvolume: '       122'
isi: 1
issue: '20'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '742985'
  name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 26538374-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I03630
  name: Molecular mechanisms of endocytic cargo recognition in plants
publication: Proceedings of the National Academy of Sciences
publication_identifier:
  eissn:
  - 1091-6490
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
related_material:
  link:
  - description: News on ISTA website
    relation: press_release
    url: https://ista.ac.at/en/news/how-roots-forage-for-water/
scopus_import: '1'
status: public
title: Foraging for water by MIZ1-mediated antagonism between root gravitropism and
  hydrotropism
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 122
year: '2025'
...
