---
_id: '2858'
abstract:
- lang: eng
text: Tumor growth is caused by the acquisition of driver mutations, which enhance
the net reproductive rate of cells. Driver mutations may increase cell division,
reduce cell death, or allow cells to overcome density-limiting effects. We study
the dynamics of tumor growth as one additional driver mutation is acquired. Our
models are based on two-type branching processes that terminate in either tumor
disappearance or tumor detection. In our first model, both cell types grow exponentially,
with a faster rate for cells carrying the additional driver. We find that the
additional driver mutation does not affect the survival probability of the lesion,
but can substantially reduce the time to reach the detectable size if the lesion
is slow growing. In our second model, cells lacking the additional driver cannot
exceed a fixed carrying capacity, due to density limitations. In this case, the
time to detection depends strongly on this carrying capacity. Our model provides
a quantitative framework for studying tumor dynamics during different stages of
progression. We observe that early, small lesions need additional drivers, while
late stage metastases are only marginally affected by them. These results help
to explain why additional driver mutations are typically not detected in fast-growing
metastases.
article_processing_charge: No
author:
- first_name: Johannes
full_name: Reiter, Johannes
id: 4A918E98-F248-11E8-B48F-1D18A9856A87
last_name: Reiter
orcid: 0000-0002-0170-7353
- first_name: Ivana
full_name: Božić, Ivana
last_name: Božić
- first_name: Benjamin
full_name: Allen, Benjamin
id: 135B5B70-E9D2-11E9-BD74-BB415DA2B523
last_name: Allen
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin
full_name: Nowak, Martin
last_name: Nowak
citation:
ama: Reiter J, Božić I, Allen B, Chatterjee K, Nowak M. The effect of one additional
driver mutation on tumor progression. Evolutionary Applications. 2013;6(1):34-45.
doi:10.1111/eva.12020
apa: Reiter, J., Božić, I., Allen, B., Chatterjee, K., & Nowak, M. (2013). The
effect of one additional driver mutation on tumor progression. Evolutionary
Applications. Wiley-Blackwell. https://doi.org/10.1111/eva.12020
chicago: Reiter, Johannes, Ivana Božić, Benjamin Allen, Krishnendu Chatterjee, and
Martin Nowak. “The Effect of One Additional Driver Mutation on Tumor Progression.”
Evolutionary Applications. Wiley-Blackwell, 2013. https://doi.org/10.1111/eva.12020.
ieee: J. Reiter, I. Božić, B. Allen, K. Chatterjee, and M. Nowak, “The effect of
one additional driver mutation on tumor progression,” Evolutionary Applications,
vol. 6, no. 1. Wiley-Blackwell, pp. 34–45, 2013.
ista: Reiter J, Božić I, Allen B, Chatterjee K, Nowak M. 2013. The effect of one
additional driver mutation on tumor progression. Evolutionary Applications. 6(1),
34–45.
mla: Reiter, Johannes, et al. “The Effect of One Additional Driver Mutation on Tumor
Progression.” Evolutionary Applications, vol. 6, no. 1, Wiley-Blackwell,
2013, pp. 34–45, doi:10.1111/eva.12020.
short: J. Reiter, I. Božić, B. Allen, K. Chatterjee, M. Nowak, Evolutionary Applications
6 (2013) 34–45.
corr_author: '1'
date_created: 2018-12-11T11:59:58Z
date_published: 2013-01-01T00:00:00Z
date_updated: 2026-07-29T10:15:25Z
day: '01'
ddc:
- '570'
department:
- _id: KrCh
doi: 10.1111/eva.12020
ec_funded: 1
external_id:
isi:
- '000313878800004'
file:
- access_level: open_access
checksum: e2955b3889f8a823c3d5a72cb16f8957
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:50Z
date_updated: 2020-07-14T12:45:51Z
file_id: '5173'
file_name: IST-2016-415-v1+1_Reiter_et_al-2013-Evolutionary_Applications.pdf
file_size: 1172037
relation: main_file
file_date_updated: 2020-07-14T12:45:51Z
fulldoi: https://doi.org/10.1111/eva.12020
has_accepted_license: '1'
intvolume: ' 6'
isi: 1
issue: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '01'
oa: 1
oa_version: Published Version
page: 34 - 45
project:
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
publication: Evolutionary Applications
publication_status: published
publisher: Wiley-Blackwell
publist_id: '3931'
pubrep_id: '415'
quality_controlled: '1'
related_material:
record:
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relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: The effect of one additional driver mutation on tumor progression
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 6
year: '2013'
...
---
_id: '2816'
abstract:
- lang: eng
text: In solid tumors, targeted treatments can lead to dramatic regressions, but
responses are often short-lived because resistant cancer cells arise. The major
strategy proposed for overcoming resistance is combination therapy. We present
a mathematical model describing the evolutionary dynamics of lesions in response
to treatment. We first studied 20 melanoma patients receiving vemurafenib. We
then applied our model to an independent set of pancreatic, colorectal, and melanoma
cancer patients with metastatic disease. We find that dual therapy results in
long-term disease control for most patients, if there are no single mutations
that cause cross-resistance to both drugs; in patients with large disease burden,
triple therapy is needed. We also find that simultaneous therapy with two drugs
is much more effective than sequential therapy. Our results provide realistic
expectations for the efficacy of new drug combinations and inform the design of
trials for new cancer therapeutics.
article_number: e00747
article_processing_charge: No
author:
- first_name: Ivana
full_name: Božić, Ivana
last_name: Božić
- first_name: Johannes
full_name: Reiter, Johannes
id: 4A918E98-F248-11E8-B48F-1D18A9856A87
last_name: Reiter
orcid: 0000-0002-0170-7353
- first_name: Benjamin
full_name: Allen, Benjamin
last_name: Allen
- first_name: Tibor
full_name: Antal, Tibor
last_name: Antal
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Preya
full_name: Shah, Preya
last_name: Shah
- first_name: Yo
full_name: Moon, Yo
last_name: Moon
- first_name: Amin
full_name: Yaqubie, Amin
last_name: Yaqubie
- first_name: Nicole
full_name: Kelly, Nicole
last_name: Kelly
- first_name: Dung
full_name: Le, Dung
last_name: Le
- first_name: Evan
full_name: Lipson, Evan
last_name: Lipson
- first_name: Paul
full_name: Chapman, Paul
last_name: Chapman
- first_name: Luis
full_name: Diaz, Luis
last_name: Diaz
- first_name: Bert
full_name: Vogelstein, Bert
last_name: Vogelstein
- first_name: Martin
full_name: Nowak, Martin
last_name: Nowak
citation:
ama: Božić I, Reiter J, Allen B, et al. Evolutionary dynamics of cancer in response
to targeted combination therapy. eLife. 2013;2. doi:10.7554/eLife.00747
apa: Božić, I., Reiter, J., Allen, B., Antal, T., Chatterjee, K., Shah, P., … Nowak,
M. (2013). Evolutionary dynamics of cancer in response to targeted combination
therapy. ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.00747
chicago: Božić, Ivana, Johannes Reiter, Benjamin Allen, Tibor Antal, Krishnendu
Chatterjee, Preya Shah, Yo Moon, et al. “Evolutionary Dynamics of Cancer in Response
to Targeted Combination Therapy.” ELife. eLife Sciences Publications, 2013.
https://doi.org/10.7554/eLife.00747.
ieee: I. Božić et al., “Evolutionary dynamics of cancer in response to targeted
combination therapy,” eLife, vol. 2. eLife Sciences Publications, 2013.
ista: Božić I, Reiter J, Allen B, Antal T, Chatterjee K, Shah P, Moon Y, Yaqubie
A, Kelly N, Le D, Lipson E, Chapman P, Diaz L, Vogelstein B, Nowak M. 2013. Evolutionary
dynamics of cancer in response to targeted combination therapy. eLife. 2, e00747.
mla: Božić, Ivana, et al. “Evolutionary Dynamics of Cancer in Response to Targeted
Combination Therapy.” ELife, vol. 2, e00747, eLife Sciences Publications,
2013, doi:10.7554/eLife.00747.
short: I. Božić, J. Reiter, B. Allen, T. Antal, K. Chatterjee, P. Shah, Y. Moon,
A. Yaqubie, N. Kelly, D. Le, E. Lipson, P. Chapman, L. Diaz, B. Vogelstein, M.
Nowak, ELife 2 (2013).
date_created: 2018-12-11T11:59:45Z
date_published: 2013-06-25T00:00:00Z
date_updated: 2026-07-29T10:15:25Z
day: '25'
ddc:
- '570'
- '610'
department:
- _id: KrCh
doi: 10.7554/eLife.00747
external_id:
isi:
- '000328619300005'
file:
- access_level: open_access
checksum: 2c38c47815eacd8fa66cb8b404cf7c61
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:12:48Z
date_updated: 2020-07-14T12:45:49Z
file_id: '4967'
file_name: IST-2013-134-v1+1_e00747.full.pdf
file_size: 3358321
relation: main_file
file_date_updated: 2020-07-14T12:45:49Z
fulldoi: https://doi.org/10.7554/eLife.00747
has_accepted_license: '1'
intvolume: ' 2'
isi: 1
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
publication: eLife
publication_status: published
publisher: eLife Sciences Publications
publist_id: '3985'
pubrep_id: '134'
quality_controlled: '1'
related_material:
record:
- id: '1400'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Evolutionary dynamics of cancer in response to targeted combination therapy
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 2
year: '2013'
...
---
_id: '2000'
abstract:
- lang: eng
text: In this work we present a flexible tool for tumor progression, which simulates
the evolutionary dynamics of cancer. Tumor progression implements a multi-type
branching process where the key parameters are the fitness landscape, the mutation
rate, and the average time of cell division. The fitness of a cancer cell depends
on the mutations it has accumulated. The input to our tool could be any fitness
landscape, mutation rate, and cell division time, and the tool produces the growth
dynamics and all relevant statistics.
alternative_title:
- LNCS
arxiv: 1
author:
- first_name: Johannes
full_name: Reiter, Johannes
id: 4A918E98-F248-11E8-B48F-1D18A9856A87
last_name: Reiter
orcid: 0000-0002-0170-7353
- first_name: Ivana
full_name: Božić, Ivana
last_name: Božić
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin
full_name: Nowak, Martin
last_name: Nowak
citation:
ama: 'Reiter J, Božić I, Chatterjee K, Nowak M. TTP: Tool for tumor progression.
In: Proceedings of 25th Int. Conf. on Computer Aided Verification. Vol
8044. Lecture Notes in Computer Science. Springer; 2013:101-106. doi:10.1007/978-3-642-39799-8_6'
apa: 'Reiter, J., Božić, I., Chatterjee, K., & Nowak, M. (2013). TTP: Tool for
tumor progression. In Proceedings of 25th Int. Conf. on Computer Aided Verification
(Vol. 8044, pp. 101–106). St. Petersburg, Russia: Springer. https://doi.org/10.1007/978-3-642-39799-8_6'
chicago: 'Reiter, Johannes, Ivana Božić, Krishnendu Chatterjee, and Martin Nowak.
“TTP: Tool for Tumor Progression.” In Proceedings of 25th Int. Conf. on Computer
Aided Verification, 8044:101–6. Lecture Notes in Computer Science. Springer,
2013. https://doi.org/10.1007/978-3-642-39799-8_6.'
ieee: 'J. Reiter, I. Božić, K. Chatterjee, and M. Nowak, “TTP: Tool for tumor progression,”
in Proceedings of 25th Int. Conf. on Computer Aided Verification, St. Petersburg,
Russia, 2013, vol. 8044, pp. 101–106.'
ista: 'Reiter J, Božić I, Chatterjee K, Nowak M. 2013. TTP: Tool for tumor progression.
Proceedings of 25th Int. Conf. on Computer Aided Verification. CAV: Computer Aided
VerificationLecture Notes in Computer Science, LNCS, vol. 8044, 101–106.'
mla: 'Reiter, Johannes, et al. “TTP: Tool for Tumor Progression.” Proceedings
of 25th Int. Conf. on Computer Aided Verification, vol. 8044, Springer, 2013,
pp. 101–06, doi:10.1007/978-3-642-39799-8_6.'
short: J. Reiter, I. Božić, K. Chatterjee, M. Nowak, in:, Proceedings of 25th Int.
Conf. on Computer Aided Verification, Springer, 2013, pp. 101–106.
conference:
end_date: 2013-07-19
location: St. Petersburg, Russia
name: 'CAV: Computer Aided Verification'
start_date: 2013-07-13
date_created: 2018-12-11T11:55:08Z
date_published: 2013-01-01T00:00:00Z
date_updated: 2026-07-29T10:15:25Z
day: '01'
department:
- _id: KrCh
doi: 10.1007/978-3-642-39799-8_6
ec_funded: 1
external_id:
arxiv:
- '1303.5251'
fulldoi: https://doi.org/10.1007/978-3-642-39799-8_6
intvolume: ' 8044'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1303.5251
month: '01'
oa: 1
oa_version: Preprint
page: 101 - 106
project:
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 2587B514-B435-11E9-9278-68D0E5697425
name: Microsoft Research Faculty Fellowship
publication: Proceedings of 25th Int. Conf. on Computer Aided Verification
publication_status: published
publisher: Springer
publist_id: '5077'
quality_controlled: '1'
related_material:
record:
- id: '5399'
relation: earlier_version
status: public
- id: '1400'
relation: dissertation_contains
status: public
scopus_import: 1
series_title: Lecture Notes in Computer Science
status: public
title: 'TTP: Tool for tumor progression'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8044
year: '2013'
...
---
OA_place: publisher
OA_type: free access
_id: '22508'
abstract:
- lang: eng
text: High-resolution space-time stochastic models for precipitation are crucial
for hydrological applications related to flood risk and water resources management.
In this study, we present a new stochastic space-time model, STREAP, which is
capable of reproducing essential features of the statistical structure of precipitation
in space and time for a wide range of scales, and at the same time can be used
for continuous simulation. The model is based on a three-stage hierarchical structure
that mimics the precipitation formation process. The stages describe the storm
arrival process, the temporal evolution of areal mean precipitation intensity
and wet area, and the evolution in time of the two-dimensional storm structure.
Each stage of the model is based on appropriate stochastic modeling techniques
spanning from point processes, multivariate stochastic simulation and random fields.
Details of the calibration and simulation procedures in each stage are provided
so that they can be easily reproduced. STREAP is applied to a case study in Switzerland
using 7 years of high-resolution (2 × 2 km2; 5 min) data from weather radars.
The model is also compared with a popular parsimonious space-time stochastic model
based on point processes (space-time Neyman-Scott) which it outperforms mainly
because of a better description of spatial precipitation. The model validation
and comparison is based on an extensive evaluation of both areal and point scale
statistics at hydrologically relevant temporal scales, focusing mainly on the
reproduction of the probability distributions of rainfall intensities, correlation
structure, and the reproduction of intermittency and wet spell duration statistics.
The results shows that a more accurate description of the space-time structure
of precipitation fields in stochastic models such as STREAP does indeed lead to
a better performance for properties and at scales which are not used in model
calibration.
alternative_title:
- A Stochastic Model for Space-Time Precipitation
article_processing_charge: No
article_type: original
author:
- first_name: Athanasios
full_name: Paschalis, Athanasios
last_name: Paschalis
- first_name: Peter
full_name: Molnar, Peter
last_name: Molnar
- first_name: Simone
full_name: Fatichi, Simone
id: cf8e546b-a9b0-11f0-a43b-aa89ed1b56d6
last_name: Fatichi
- first_name: Paolo
full_name: Burlando, Paolo
last_name: Burlando
citation:
ama: Paschalis A, Molnar P, Fatichi S, Burlando P. A stochastic model for high-resolution
space-time precipitation simulation. Water Resources Research. 2013;49(12):8400-8417.
doi:10.1002/2013wr014437
apa: Paschalis, A., Molnar, P., Fatichi, S., & Burlando, P. (2013). A stochastic
model for high-resolution space-time precipitation simulation. Water Resources
Research. American Geophysical Union. https://doi.org/10.1002/2013wr014437
chicago: Paschalis, Athanasios, Peter Molnar, Simone Fatichi, and Paolo Burlando.
“A Stochastic Model for High-Resolution Space-Time Precipitation Simulation.”
Water Resources Research. American Geophysical Union, 2013. https://doi.org/10.1002/2013wr014437.
ieee: A. Paschalis, P. Molnar, S. Fatichi, and P. Burlando, “A stochastic model
for high-resolution space-time precipitation simulation,” Water Resources Research,
vol. 49, no. 12. American Geophysical Union, pp. 8400–8417, 2013.
ista: Paschalis A, Molnar P, Fatichi S, Burlando P. 2013. A stochastic model for
high-resolution space-time precipitation simulation. Water Resources Research.
49(12), 8400–8417.
mla: Paschalis, Athanasios, et al. “A Stochastic Model for High-Resolution Space-Time
Precipitation Simulation.” Water Resources Research, vol. 49, no. 12, American
Geophysical Union, 2013, pp. 8400–17, doi:10.1002/2013wr014437.
short: A. Paschalis, P. Molnar, S. Fatichi, P. Burlando, Water Resources Research
49 (2013) 8400–8417.
das_tickbox: '1'
date_created: 2026-07-27T12:30:24Z
date_published: 2013-12-01T00:00:00Z
date_updated: 2026-08-06T08:09:42Z
day: '01'
doi: 10.1002/2013wr014437
extern: '1'
fulldoi: https://doi.org/10.1002/2013wr014437
intvolume: ' 49'
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.1002/2013WR014437'
month: '12'
oa: 1
oa_version: Published Version
page: 8400-8417
publication: Water Resources Research
publication_identifier:
eissn:
- 1944-7973
issn:
- 0043-1397
publication_status: published
publisher: American Geophysical Union
quality_controlled: '1'
scopus_import: '1'
status: public
title: A stochastic model for high-resolution space-time precipitation simulation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 49
year: '2013'
...
---
OA_place: publisher
OA_type: free access
_id: '22552'
abstract:
- lang: eng
text: Dynamic vegetation models have been widely used for analyzing ecosystem dynamics
and their interactions with climate. Their performance has been tested extensively
against observations and by model intercomparison studies. In the present analysis,
Lund-Potsdam-Jena General Ecosystem Simulator (LPJ-GUESS), a state-of-the-art
ecosystem model, was evaluated by performing a global sensitivity analysis. The
study aims at examining potential model limitations, particularly with regard
to long-term applications. A detailed sensitivity analysis based on variance decomposition
is presented to investigate structural model assumptions and to highlight processes
and parameters that cause the highest variability in the output. First- and total-order
sensitivity indices were calculated for selected parameters using Sobol's methodology.
In order to elucidate the role of climate on model sensitivity, different climate
forcings were used based on observations from Switzerland. The results clearly
indicate a very high sensitivity of LPJ-GUESS to photosynthetic parameters. Intrinsic
quantum efficiency alone is able to explain about 60% of the variability in vegetation
carbon fluxes and pools for a wide range of climate forcings. Processes related
to light harvesting were also found to be important together with parameters affecting
forest structure (growth, establishment, and mortality). The model shows minor
sensitivity to hydrological and soil texture parameters, questioning its skills
in representing spatial vegetation heterogeneity at regional or watershed scales.
In the light of these results, we discuss the deficiencies of LPJ-GUESS and possibly
that of other, structurally similar, dynamic vegetation models and we highlight
potential directions for further model improvements.
article_processing_charge: No
article_type: original
author:
- first_name: Christoforos
full_name: Pappas, Christoforos
last_name: Pappas
- first_name: Simone
full_name: Fatichi, Simone
id: cf8e546b-a9b0-11f0-a43b-aa89ed1b56d6
last_name: Fatichi
- first_name: Sebastian
full_name: Leuzinger, Sebastian
last_name: Leuzinger
- first_name: Annett
full_name: Wolf, Annett
last_name: Wolf
- first_name: Paolo
full_name: Burlando, Paolo
last_name: Burlando
citation:
ama: 'Pappas C, Fatichi S, Leuzinger S, Wolf A, Burlando P. Sensitivity analysis
of a process‐based ecosystem model: Pinpointing parameterization and structural
issues. Journal of Geophysical Research: Biogeosciences. 2013;118(2):505-528.
doi:10.1002/jgrg.20035'
apa: 'Pappas, C., Fatichi, S., Leuzinger, S., Wolf, A., & Burlando, P. (2013).
Sensitivity analysis of a process‐based ecosystem model: Pinpointing parameterization
and structural issues. Journal of Geophysical Research: Biogeosciences.
American Geophysical Union. https://doi.org/10.1002/jgrg.20035'
chicago: 'Pappas, Christoforos, Simone Fatichi, Sebastian Leuzinger, Annett Wolf,
and Paolo Burlando. “Sensitivity Analysis of a Process‐based Ecosystem Model:
Pinpointing Parameterization and Structural Issues.” Journal of Geophysical
Research: Biogeosciences. American Geophysical Union, 2013. https://doi.org/10.1002/jgrg.20035.'
ieee: 'C. Pappas, S. Fatichi, S. Leuzinger, A. Wolf, and P. Burlando, “Sensitivity
analysis of a process‐based ecosystem model: Pinpointing parameterization and
structural issues,” Journal of Geophysical Research: Biogeosciences, vol.
118, no. 2. American Geophysical Union, pp. 505–528, 2013.'
ista: 'Pappas C, Fatichi S, Leuzinger S, Wolf A, Burlando P. 2013. Sensitivity analysis
of a process‐based ecosystem model: Pinpointing parameterization and structural
issues. Journal of Geophysical Research: Biogeosciences. 118(2), 505–528.'
mla: 'Pappas, Christoforos, et al. “Sensitivity Analysis of a Process‐based Ecosystem
Model: Pinpointing Parameterization and Structural Issues.” Journal of Geophysical
Research: Biogeosciences, vol. 118, no. 2, American Geophysical Union, 2013,
pp. 505–28, doi:10.1002/jgrg.20035.'
short: 'C. Pappas, S. Fatichi, S. Leuzinger, A. Wolf, P. Burlando, Journal of Geophysical
Research: Biogeosciences 118 (2013) 505–528.'
das_tickbox: '1'
date_created: 2026-07-27T12:30:24Z
date_published: 2013-06-01T00:00:00Z
date_updated: 2026-08-06T08:17:13Z
day: '01'
doi: 10.1002/jgrg.20035
extern: '1'
fulldoi: https://doi.org/10.1002/jgrg.20035
intvolume: ' 118'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.1002/jgrg.20035'
month: '06'
oa: 1
oa_version: Published Version
page: 505-528
publication: 'Journal of Geophysical Research: Biogeosciences'
publication_identifier:
eissn:
- 2169-8961
issn:
- 2169-8953
publication_status: published
publisher: American Geophysical Union
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Sensitivity analysis of a process‐based ecosystem model: Pinpointing parameterization
and structural issues'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 118
year: '2013'
...
---
_id: '450'
abstract:
- lang: eng
text: Understanding the relative importance of heterosis and outbreeding depression
over multiple generations is a key question in evolutionary biology and is essential
for identifying appropriate genetic sources for population and ecosystem restoration.
Here we use 2455 experimental crosses between 12 population pairs of the rare
perennial plant Rutidosis leptorrhynchoides (Asteraceae) to investigate the multi-generational
(F1, F2, F3) fitness outcomes of inter-population hybridization. We detected no
evidence of outbreeding depression, with inter-population hybrids and backcrosses
showing either similar fitness or significant heterosis for fitness components
across the three generations. Variation in heterosis among population pairs was
best explained by characteristics of the foreign source or home population, and
was greatest when the source population was large, with high genetic diversity
and low inbreeding, and the home population was small and inbred. Our results
indicate that the primary consideration for maximizing progeny fitness following
population augmentation or restoration is the use of seed from large, genetically
diverse populations.
article_number: '2058'
article_processing_charge: No
author:
- first_name: Melinda
full_name: Pickup, Melinda
id: 2C78037E-F248-11E8-B48F-1D18A9856A87
last_name: Pickup
orcid: 0000-0001-6118-0541
- first_name: David
full_name: Field, David
id: 419049E2-F248-11E8-B48F-1D18A9856A87
last_name: Field
orcid: 0000-0002-4014-8478
- first_name: David
full_name: Rowell, David
last_name: Rowell
- first_name: Andrew
full_name: Young, Andrew
last_name: Young
citation:
ama: Pickup M, Field D, Rowell D, Young A. Source population characteristics affect
heterosis following genetic rescue of fragmented plant populations. Proceedings
of the Royal Society of London Series B Biological Sciences. 2013;280(1750).
doi:10.1098/rspb.2012.2058
apa: Pickup, M., Field, D., Rowell, D., & Young, A. (2013). Source population
characteristics affect heterosis following genetic rescue of fragmented plant
populations. Proceedings of the Royal Society of London Series B Biological
Sciences. Royal Society. https://doi.org/10.1098/rspb.2012.2058
chicago: Pickup, Melinda, David Field, David Rowell, and Andrew Young. “Source Population
Characteristics Affect Heterosis Following Genetic Rescue of Fragmented Plant
Populations.” Proceedings of the Royal Society of London Series B Biological
Sciences. Royal Society, 2013. https://doi.org/10.1098/rspb.2012.2058.
ieee: M. Pickup, D. Field, D. Rowell, and A. Young, “Source population characteristics
affect heterosis following genetic rescue of fragmented plant populations,” Proceedings
of the Royal Society of London Series B Biological Sciences, vol. 280, no.
1750. Royal Society, 2013.
ista: Pickup M, Field D, Rowell D, Young A. 2013. Source population characteristics
affect heterosis following genetic rescue of fragmented plant populations. Proceedings
of the Royal Society of London Series B Biological Sciences. 280(1750), 2058.
mla: Pickup, Melinda, et al. “Source Population Characteristics Affect Heterosis
Following Genetic Rescue of Fragmented Plant Populations.” Proceedings of the
Royal Society of London Series B Biological Sciences, vol. 280, no. 1750,
2058, Royal Society, 2013, doi:10.1098/rspb.2012.2058.
short: M. Pickup, D. Field, D. Rowell, A. Young, Proceedings of the Royal Society
of London Series B Biological Sciences 280 (2013).
corr_author: '1'
date_created: 2018-12-11T11:46:32Z
date_published: 2013-01-07T00:00:00Z
date_updated: 2026-08-12T06:25:53Z
day: '07'
department:
- _id: NiBa
doi: 10.1098/rspb.2012.2058
external_id:
isi:
- '000311943100012'
pmid:
- '23173202'
fulldoi: https://doi.org/10.1098/rspb.2012.2058
intvolume: ' 280'
isi: 1
issue: '1750'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574427/
month: '01'
oa: 1
oa_version: Submitted Version
pmid: 1
publication: Proceedings of the Royal Society of London Series B Biological Sciences
publication_status: published
publisher: Royal Society
publist_id: '7372'
quality_controlled: '1'
status: public
title: Source population characteristics affect heterosis following genetic rescue
of fragmented plant populations
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 280
year: '2013'
...
---
OA_type: closed access
_id: '22476'
abstract:
- lang: eng
text: Projections of the future carbon and water cycles rely on knowledge on how
forests will respond to rising atmospheric CO2. Experiments with elevated CO2
are logistically challenging and carbon pools and fluxes are difficult to measure
and upscale due to their spatiotemporal heterogeneity. Therefore, it is important
to combine the knowledge derived from experimental results with modeling. Here,
we systematically compare data from a free air CO2 enrichment (FACE) experiment
in a mature deciduous forest in Switzerland with realizations from an ecohydrological
model (Tethys–Chloris). We test whether a mechanistic ecohydrological model is
able to simulate physiological plant responses under ambient and elevated CO2
concentration. We overcome measurement limitations by quantifying differences
in response to ambient and elevated CO2 over ten years. The reliability of model
realizations is demonstrated by comparing simulations with field observations
of stomatal conductance, sap flow, leaf and fruit litter, and stem growth. The
model successfully captures the observed CO2-induced difference in stomatal conductance
and transpiration and its sensitivity to atmospheric demand, as well as qualitative
changes in soil moisture. The simulated differences between CO2 scenarios generally
fall within the uncertainty of experimental observations, both for the carbon
and water balance. Simulated total evapotranspiration is 2.8% (18 mm yr−1) lower
and soil moisture 1.2% higher in the CO2-enriched scenario. Latent and sensible
heat are modified by ca. 1 W m−2. Net primary production is simulated to increase
by 19.8% and allocation to stem growth is 53 gC yr−1 m−2 higher in the elevated
CO2 scenario, which represents the limit of the detection threshold of the experiment.
Results show that while ecohydrological models can be used to reliably simulate
multi-year energy, water, and carbon fluxes at the stand level, testing carbon
allocation remains critical with current accuracy of field measurements. Uncertainties
due to the simplified carbon allocation scheme are shown to be more significant
for carbon than for energy and water fluxes. Generally, we conclude that for this
type of forest, differences in annual energy and water fluxes induced by elevated
CO2 are likely to be less than 10%.
article_processing_charge: No
article_type: original
author:
- first_name: Simone
full_name: Fatichi, Simone
id: cf8e546b-a9b0-11f0-a43b-aa89ed1b56d6
last_name: Fatichi
- first_name: Sebastian
full_name: Leuzinger, Sebastian
last_name: Leuzinger
citation:
ama: 'Fatichi S, Leuzinger S. Reconciling observations with modeling: The fate of
water and carbon allocation in a mature deciduous forest exposed to elevated CO2.
Agricultural and Forest Meteorology. 2013;174-175:144-157. doi:10.1016/j.agrformet.2013.02.005'
apa: 'Fatichi, S., & Leuzinger, S. (2013). Reconciling observations with modeling:
The fate of water and carbon allocation in a mature deciduous forest exposed to
elevated CO2. Agricultural and Forest Meteorology. Elsevier. https://doi.org/10.1016/j.agrformet.2013.02.005'
chicago: 'Fatichi, Simone, and Sebastian Leuzinger. “Reconciling Observations with
Modeling: The Fate of Water and Carbon Allocation in a Mature Deciduous Forest
Exposed to Elevated CO2.” Agricultural and Forest Meteorology. Elsevier,
2013. https://doi.org/10.1016/j.agrformet.2013.02.005.'
ieee: 'S. Fatichi and S. Leuzinger, “Reconciling observations with modeling: The
fate of water and carbon allocation in a mature deciduous forest exposed to elevated
CO2,” Agricultural and Forest Meteorology, vol. 174–175. Elsevier, pp.
144–157, 2013.'
ista: 'Fatichi S, Leuzinger S. 2013. Reconciling observations with modeling: The
fate of water and carbon allocation in a mature deciduous forest exposed to elevated
CO2. Agricultural and Forest Meteorology. 174–175, 144–157.'
mla: 'Fatichi, Simone, and Sebastian Leuzinger. “Reconciling Observations with Modeling:
The Fate of Water and Carbon Allocation in a Mature Deciduous Forest Exposed to
Elevated CO2.” Agricultural and Forest Meteorology, vol. 174–175, Elsevier,
2013, pp. 144–57, doi:10.1016/j.agrformet.2013.02.005.'
short: S. Fatichi, S. Leuzinger, Agricultural and Forest Meteorology 174–175 (2013)
144–157.
das_tickbox: '1'
date_created: 2026-07-27T12:30:23Z
date_published: 2013-06-15T00:00:00Z
date_updated: 2026-08-12T13:59:36Z
day: '15'
doi: 10.1016/j.agrformet.2013.02.005
extern: '1'
fulldoi: https://doi.org/10.1016/j.agrformet.2013.02.005
keyword:
- Ecohydrological modeling
- Plant water relations
- FACE experiments
- Forest productivity
- CO2 enrichment
- Swiss Canopy Crane
language:
- iso: eng
month: '06'
oa_version: None
page: 144-157
publication: Agricultural and Forest Meteorology
publication_identifier:
eissn:
- 1873-2240
issn:
- 0168-1923
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Reconciling observations with modeling: The fate of water and carbon allocation
in a mature deciduous forest exposed to elevated CO2'
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 174-175
year: '2013'
...
---
OA_type: closed access
_id: '22475'
abstract:
- lang: eng
text: This study extends a stochastic downscaling methodology to generation of an
ensemble of hourly time series of meteorological variables that express possible
future climate conditions at a point-scale. The stochastic downscaling uses general
circulation model (GCM) realizations and an hourly weather generator, the Advanced
WEather GENerator (AWE-GEN). Marginal distributions of factors of change are computed
for several climate statistics using a Bayesian methodology that can weight GCM
realizations based on the model relative performance with respect to a historical
climate and a degree of disagreement in projecting future conditions. A Monte
Carlo technique is used to sample the factors of change from their respective
marginal distributions. As a comparison with traditional approaches, factors of
change are also estimated by averaging GCM realizations. With either approach,
the derived factors of change are applied to the climate statistics inferred from
historical observations to re-evaluate parameters of the weather generator. The
re-parameterized generator yields hourly time series of meteorological variables
that can be considered to be representative of future climate conditions. In this
study, the time series are generated in an ensemble mode to fully reflect the
uncertainty of GCM projections, climate stochasticity, as well as uncertainties
of the downscaling procedure. Applications of the methodology in reproducing future
climate conditions for the periods of 2000–2009, 2046–2065 and 2081–2100, using
the period of 1962–1992 as the historical baseline are discussed for the location
of Firenze (Italy). The inferences of the methodology for the period of 2000–2009
are tested against observations to assess reliability of the stochastic downscaling
procedure in reproducing statistics of meteorological variables at different time
scales.
article_processing_charge: No
article_type: original
author:
- first_name: Simone
full_name: Fatichi, Simone
id: cf8e546b-a9b0-11f0-a43b-aa89ed1b56d6
last_name: Fatichi
- first_name: V. Y.
full_name: Ivanov, V. Y.
last_name: Ivanov
- first_name: E.
full_name: Caporali, E.
last_name: Caporali
citation:
ama: Fatichi S, Ivanov VY, Caporali E. Assessment of a stochastic downscaling methodology
in generating an ensemble of hourly future climate time series. Climate Dynamics.
2013;40:1841-1861. doi:10.1007/s00382-012-1627-2
apa: Fatichi, S., Ivanov, V. Y., & Caporali, E. (2013). Assessment of a stochastic
downscaling methodology in generating an ensemble of hourly future climate time
series. Climate Dynamics. Springer Nature. https://doi.org/10.1007/s00382-012-1627-2
chicago: Fatichi, Simone, V. Y. Ivanov, and E. Caporali. “Assessment of a Stochastic
Downscaling Methodology in Generating an Ensemble of Hourly Future Climate Time
Series.” Climate Dynamics. Springer Nature, 2013. https://doi.org/10.1007/s00382-012-1627-2.
ieee: S. Fatichi, V. Y. Ivanov, and E. Caporali, “Assessment of a stochastic downscaling
methodology in generating an ensemble of hourly future climate time series,” Climate
Dynamics, vol. 40. Springer Nature, pp. 1841–1861, 2013.
ista: Fatichi S, Ivanov VY, Caporali E. 2013. Assessment of a stochastic downscaling
methodology in generating an ensemble of hourly future climate time series. Climate
Dynamics. 40, 1841–1861.
mla: Fatichi, Simone, et al. “Assessment of a Stochastic Downscaling Methodology
in Generating an Ensemble of Hourly Future Climate Time Series.” Climate Dynamics,
vol. 40, Springer Nature, 2013, pp. 1841–61, doi:10.1007/s00382-012-1627-2.
short: S. Fatichi, V.Y. Ivanov, E. Caporali, Climate Dynamics 40 (2013) 1841–1861.
das_tickbox: '1'
date_created: 2026-07-27T12:30:23Z
date_published: 2013-04-01T00:00:00Z
date_updated: 2026-08-12T14:05:37Z
day: '01'
doi: 10.1007/s00382-012-1627-2
extern: '1'
fulldoi: https://doi.org/10.1007/s00382-012-1627-2
intvolume: ' 40'
keyword:
- Stochastic downscaling
- Weather generator
- Uncertainty assessment
- Firenze
- Italy
language:
- iso: eng
month: '04'
oa_version: None
page: 1841-1861
publication: Climate Dynamics
publication_identifier:
eissn:
- 1432-0894
issn:
- 0930-7575
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Assessment of a stochastic downscaling methodology in generating an ensemble
of hourly future climate time series
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 40
year: '2013'
...
---
_id: '2811'
abstract:
- lang: eng
text: 'In pipe, channel, and boundary layer flows turbulence first occurs intermittently
in space and time: at moderate Reynolds numbers domains of disordered turbulent
motion are separated by quiescent laminar regions. Based on direct numerical simulations
of pipe flow we argue here that the spatial intermittency has its origin in a
nearest neighbor interaction between turbulent regions. We further show that in
this regime turbulent flows are intrinsically intermittent with a well-defined
equilibrium turbulent fraction but without ever assuming a steady pattern. This
transition scenario is analogous to that found in simple models such as coupled
map lattices. The scaling observed implies that laminar intermissions of the turbulent
flow will persist to arbitrarily large Reynolds numbers.'
article_number: '063012'
article_processing_charge: No
arxiv: 1
author:
- first_name: Marc
full_name: Avila, Marc
last_name: Avila
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
citation:
ama: Avila M, Hof B. Nature of laminar-turbulence intermittency in shear flows.
Physical Review E. 2013;87(6). doi:10.1103/PhysRevE.87.063012
apa: Avila, M., & Hof, B. (2013). Nature of laminar-turbulence intermittency
in shear flows. Physical Review E. American Physical Society. https://doi.org/10.1103/PhysRevE.87.063012
chicago: Avila, Marc, and Björn Hof. “Nature of Laminar-Turbulence Intermittency
in Shear Flows.” Physical Review E. American Physical Society, 2013. https://doi.org/10.1103/PhysRevE.87.063012.
ieee: M. Avila and B. Hof, “Nature of laminar-turbulence intermittency in shear
flows,” Physical Review E, vol. 87, no. 6. American Physical Society, 2013.
ista: Avila M, Hof B. 2013. Nature of laminar-turbulence intermittency in shear
flows. Physical Review E. 87(6), 063012.
mla: Avila, Marc, and Björn Hof. “Nature of Laminar-Turbulence Intermittency in
Shear Flows.” Physical Review E, vol. 87, no. 6, 063012, American Physical
Society, 2013, doi:10.1103/PhysRevE.87.063012.
short: M. Avila, B. Hof, Physical Review E 87 (2013).
date_created: 2018-12-11T11:59:43Z
date_published: 2013-06-18T00:00:00Z
date_updated: 2026-08-12T14:29:19Z
day: '18'
department:
- _id: BjHo
doi: 10.1103/PhysRevE.87.063012
ec_funded: 1
external_id:
arxiv:
- '1306.5890'
isi:
- '000320645700009'
fulldoi: https://doi.org/10.1103/PhysRevE.87.063012
intvolume: ' 87'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1306.5890
month: '06'
oa: 1
oa_version: Preprint
project:
- _id: 25152F3A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '306589'
name: Decoding the complexity of turbulence at its origin
publication: Physical Review E
publication_status: published
publisher: American Physical Society
publist_id: '4074'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nature of laminar-turbulence intermittency in shear flows
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 87
year: '2013'
...
---
_id: '10896'
abstract:
- lang: eng
text: Under physiological conditions the brain, via the purine salvage pathway,
reuses the preformed purine bases hypoxanthine, derived from ATP degradation,
and adenine (Ade), derived from polyamine synthesis, to restore its ATP pool.
However, the massive degradation of ATP during ischemia, although providing valuable
neuroprotective adenosine, results in the accumulation and loss of diffusible
purine metabolites and thereby leads to a protracted reduction in the post-ischemic
ATP pool size. In vivo, this may both limit the ability to deploy ATP-dependent
reparative mechanisms and reduce the subsequent availability of adenosine, whilst
in brain slices results in tissue with substantially lower levels of ATP than
in vivo. In the present review, we describe the mechanisms by which brain tissue
replenishes its ATP, how this can be improved with the clinically tolerated chemicals
D-ribose and adenine, and the functional, and potential therapeutic, implications
of doing so.
acknowledgement: We are grateful to Research into Ageing/Ageing UK and The Dunhill
Trust for funding SzN’s graduate studies, and to Prof Nicholas Dale for his valuable
input.
article_processing_charge: No
author:
- first_name: Stephanie
full_name: zur Nedden, Stephanie
id: 3C77F464-F248-11E8-B48F-1D18A9856A87
last_name: zur Nedden
- first_name: Alexander S.
full_name: Doney, Alexander S.
last_name: Doney
- first_name: Bruno G.
full_name: Frenguelli, Bruno G.
last_name: Frenguelli
citation:
ama: 'zur Nedden S, Doney AS, Frenguelli BG. The double-edged sword: Gaining Adenosine
at the expense of ATP. How to balance the books. In: Masino S, Boison D, eds.
Adenosine. 1st ed. New York: Springer; 2012:109-129. doi:10.1007/978-1-4614-3903-5_6'
apa: 'zur Nedden, S., Doney, A. S., & Frenguelli, B. G. (2012). The double-edged
sword: Gaining Adenosine at the expense of ATP. How to balance the books. In S.
Masino & D. Boison (Eds.), Adenosine (1st ed., pp. 109–129). New York:
Springer. https://doi.org/10.1007/978-1-4614-3903-5_6'
chicago: 'Nedden, Stephanie zur, Alexander S. Doney, and Bruno G. Frenguelli. “The
Double-Edged Sword: Gaining Adenosine at the Expense of ATP. How to Balance the
Books.” In Adenosine, edited by Susan Masino and Detlev Boison, 1st ed.,
109–29. New York: Springer, 2012. https://doi.org/10.1007/978-1-4614-3903-5_6.'
ieee: 'S. zur Nedden, A. S. Doney, and B. G. Frenguelli, “The double-edged sword:
Gaining Adenosine at the expense of ATP. How to balance the books,” in Adenosine,
1st ed., S. Masino and D. Boison, Eds. New York: Springer, 2012, pp. 109–129.'
ista: 'zur Nedden S, Doney AS, Frenguelli BG. 2012.The double-edged sword: Gaining
Adenosine at the expense of ATP. How to balance the books. In: Adenosine. , 109–129.'
mla: 'zur Nedden, Stephanie, et al. “The Double-Edged Sword: Gaining Adenosine at
the Expense of ATP. How to Balance the Books.” Adenosine, edited by Susan
Masino and Detlev Boison, 1st ed., Springer, 2012, pp. 109–29, doi:10.1007/978-1-4614-3903-5_6.'
short: S. zur Nedden, A.S. Doney, B.G. Frenguelli, in:, S. Masino, D. Boison (Eds.),
Adenosine, 1st ed., Springer, New York, 2012, pp. 109–129.
date_created: 2022-03-21T07:16:12Z
date_published: 2012-07-23T00:00:00Z
date_updated: 2022-06-21T11:51:58Z
day: '23'
department:
- _id: HaJa
doi: 10.1007/978-1-4614-3903-5_6
edition: '1'
editor:
- first_name: Susan
full_name: Masino, Susan
last_name: Masino
- first_name: Detlev
full_name: Boison, Detlev
last_name: Boison
fulldoi: https://doi.org/10.1007/978-1-4614-3903-5_6
language:
- iso: eng
month: '07'
oa_version: None
page: 109-129
place: New York
publication: Adenosine
publication_identifier:
eisbn:
- '9781461439035'
isbn:
- '9781461439028'
publication_status: published
publisher: Springer
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The double-edged sword: Gaining Adenosine at the expense of ATP. How to balance
the books'
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2012'
...
---
_id: '10903'
abstract:
- lang: eng
text: We propose a logic-based framework for automated reasoning about sequential
programs manipulating singly-linked lists and arrays with unbounded data. We introduce
the logic SLAD, which allows combining shape constraints, written in a fragment
of Separation Logic, with data and size constraints. We address the problem of
checking the entailment between SLAD formulas, which is crucial in performing
pre-post condition reasoning. Although this problem is undecidable in general
for SLAD, we propose a sound and powerful procedure that is able to solve this
problem for a large class of formulas, beyond the capabilities of existing techniques
and tools. We prove that this procedure is complete, i.e., it is actually a decision
procedure for this problem, for an important fragment of SLAD including known
decidable logics. We implemented this procedure and shown its preciseness and
its efficiency on a significant benchmark of formulas.
acknowledgement: This work has been partially supported by the French ANR project
Veridyc
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Ahmed
full_name: Bouajjani, Ahmed
last_name: Bouajjani
- first_name: Cezara
full_name: Dragoi, Cezara
id: 2B2B5ED0-F248-11E8-B48F-1D18A9856A87
last_name: Dragoi
- first_name: Constantin
full_name: Enea, Constantin
last_name: Enea
- first_name: Mihaela
full_name: Sighireanu, Mihaela
last_name: Sighireanu
citation:
ama: 'Bouajjani A, Dragoi C, Enea C, Sighireanu M. Accurate invariant checking for
programs manipulating lists and arrays with infinite data. In: Automated Technology
for Verification and Analysis. Vol 7561. LNCS. Berlin, Heidelberg: Springer;
2012:167-182. doi:10.1007/978-3-642-33386-6_14'
apa: 'Bouajjani, A., Dragoi, C., Enea, C., & Sighireanu, M. (2012). Accurate
invariant checking for programs manipulating lists and arrays with infinite data.
In Automated Technology for Verification and Analysis (Vol. 7561, pp. 167–182).
Berlin, Heidelberg: Springer. https://doi.org/10.1007/978-3-642-33386-6_14'
chicago: 'Bouajjani, Ahmed, Cezara Dragoi, Constantin Enea, and Mihaela Sighireanu.
“Accurate Invariant Checking for Programs Manipulating Lists and Arrays with Infinite
Data.” In Automated Technology for Verification and Analysis, 7561:167–82.
LNCS. Berlin, Heidelberg: Springer, 2012. https://doi.org/10.1007/978-3-642-33386-6_14.'
ieee: A. Bouajjani, C. Dragoi, C. Enea, and M. Sighireanu, “Accurate invariant checking
for programs manipulating lists and arrays with infinite data,” in Automated
Technology for Verification and Analysis, Thiruvananthapuram, India, 2012,
vol. 7561, pp. 167–182.
ista: 'Bouajjani A, Dragoi C, Enea C, Sighireanu M. 2012. Accurate invariant checking
for programs manipulating lists and arrays with infinite data. Automated Technology
for Verification and Analysis. ATVA: Automated Technology for Verification and
AnalysisLNCS, LNCS, vol. 7561, 167–182.'
mla: Bouajjani, Ahmed, et al. “Accurate Invariant Checking for Programs Manipulating
Lists and Arrays with Infinite Data.” Automated Technology for Verification
and Analysis, vol. 7561, Springer, 2012, pp. 167–82, doi:10.1007/978-3-642-33386-6_14.
short: A. Bouajjani, C. Dragoi, C. Enea, M. Sighireanu, in:, Automated Technology
for Verification and Analysis, Springer, Berlin, Heidelberg, 2012, pp. 167–182.
conference:
end_date: 2012-10-06
location: Thiruvananthapuram, India
name: 'ATVA: Automated Technology for Verification and Analysis'
start_date: 2012-10-03
corr_author: '1'
date_created: 2022-03-21T07:58:39Z
date_published: 2012-10-15T00:00:00Z
date_updated: 2024-10-09T21:02:34Z
day: '15'
department:
- _id: ToHe
doi: 10.1007/978-3-642-33386-6_14
fulldoi: https://doi.org/10.1007/978-3-642-33386-6_14
intvolume: ' 7561'
language:
- iso: eng
month: '10'
oa_version: None
page: 167-182
place: Berlin, Heidelberg
publication: Automated Technology for Verification and Analysis
publication_identifier:
eisbn:
- '9783642333866'
eissn:
- 1611-3349
isbn:
- '9783642333859'
issn:
- 0302-9743
publication_status: published
publisher: Springer
quality_controlled: '1'
scopus_import: '1'
series_title: LNCS
status: public
title: Accurate invariant checking for programs manipulating lists and arrays with
infinite data
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 7561
year: '2012'
...
---
_id: '11089'
abstract:
- lang: eng
text: The Nuclear Envelope (NE) contains over 100 different proteins that associate
with nuclear components such as chromatin, the lamina and the transcription machinery.
Mutations in genes encoding NE proteins have been shown to result in tissue-specific
defects and disease, suggesting cell-type specific differences in NE composition
and function. Consistent with these observations, recent studies have revealed
unexpected functions for numerous NE associated proteins during cell differentiation
and development. Here we review the latest insights into the roles played by the
NE in cell differentiation, development, disease and aging, focusing primarily
on inner nuclear membrane (INM) proteins and nuclear pore components.
article_processing_charge: No
article_type: original
author:
- first_name: J Sebastian
full_name: Gomez-Cavazos, J Sebastian
last_name: Gomez-Cavazos
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: 'Gomez-Cavazos JS, Hetzer M. Outfits for different occasions: tissue-specific
roles of Nuclear Envelope proteins. Current Opinion in Cell Biology. 2012;24(6):775-783.
doi:10.1016/j.ceb.2012.08.008'
apa: 'Gomez-Cavazos, J. S., & Hetzer, M. (2012). Outfits for different occasions:
tissue-specific roles of Nuclear Envelope proteins. Current Opinion in Cell
Biology. Elsevier. https://doi.org/10.1016/j.ceb.2012.08.008'
chicago: 'Gomez-Cavazos, J Sebastian, and Martin Hetzer. “Outfits for Different
Occasions: Tissue-Specific Roles of Nuclear Envelope Proteins.” Current Opinion
in Cell Biology. Elsevier, 2012. https://doi.org/10.1016/j.ceb.2012.08.008.'
ieee: 'J. S. Gomez-Cavazos and M. Hetzer, “Outfits for different occasions: tissue-specific
roles of Nuclear Envelope proteins,” Current Opinion in Cell Biology, vol.
24, no. 6. Elsevier, pp. 775–783, 2012.'
ista: 'Gomez-Cavazos JS, Hetzer M. 2012. Outfits for different occasions: tissue-specific
roles of Nuclear Envelope proteins. Current Opinion in Cell Biology. 24(6), 775–783.'
mla: 'Gomez-Cavazos, J. Sebastian, and Martin Hetzer. “Outfits for Different Occasions:
Tissue-Specific Roles of Nuclear Envelope Proteins.” Current Opinion in Cell
Biology, vol. 24, no. 6, Elsevier, 2012, pp. 775–83, doi:10.1016/j.ceb.2012.08.008.'
short: J.S. Gomez-Cavazos, M. Hetzer, Current Opinion in Cell Biology 24 (2012)
775–783.
date_created: 2022-04-07T07:51:37Z
date_published: 2012-12-01T00:00:00Z
date_updated: 2024-10-14T11:25:04Z
day: '01'
doi: 10.1016/j.ceb.2012.08.008
extern: '1'
external_id:
pmid:
- '22995343'
fulldoi: https://doi.org/10.1016/j.ceb.2012.08.008
intvolume: ' 24'
issue: '6'
keyword:
- Cell Biology
language:
- iso: eng
month: '12'
oa_version: None
page: 775-783
pmid: 1
publication: Current Opinion in Cell Biology
publication_identifier:
issn:
- 0955-0674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Outfits for different occasions: tissue-specific roles of Nuclear Envelope
proteins'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 24
year: '2012'
...
---
_id: '11090'
abstract:
- lang: eng
text: Nuclear export of mRNAs is thought to occur exclusively through nuclear pore
complexes. In this issue of Cell, Speese et al. identify an alternate pathway
for mRNA export in muscle cells where ribonucleoprotein complexes involved in
forming neuromuscular junctions transit the nuclear envelope by fusing with and
budding through the nuclear membrane.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Emily M.
full_name: Hatch, Emily M.
last_name: Hatch
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Hatch EM, Hetzer M. RNP export by nuclear envelope budding. Cell. 2012;149(4):733-735.
doi:10.1016/j.cell.2012.04.018
apa: Hatch, E. M., & Hetzer, M. (2012). RNP export by nuclear envelope budding.
Cell. Elsevier. https://doi.org/10.1016/j.cell.2012.04.018
chicago: Hatch, Emily M., and Martin Hetzer. “RNP Export by Nuclear Envelope Budding.”
Cell. Elsevier, 2012. https://doi.org/10.1016/j.cell.2012.04.018.
ieee: E. M. Hatch and M. Hetzer, “RNP export by nuclear envelope budding,” Cell,
vol. 149, no. 4. Elsevier, pp. 733–735, 2012.
ista: Hatch EM, Hetzer M. 2012. RNP export by nuclear envelope budding. Cell. 149(4),
733–735.
mla: Hatch, Emily M., and Martin Hetzer. “RNP Export by Nuclear Envelope Budding.”
Cell, vol. 149, no. 4, Elsevier, 2012, pp. 733–35, doi:10.1016/j.cell.2012.04.018.
short: E.M. Hatch, M. Hetzer, Cell 149 (2012) 733–735.
date_created: 2022-04-07T07:51:45Z
date_published: 2012-05-11T00:00:00Z
date_updated: 2024-10-14T11:25:24Z
day: '11'
doi: 10.1016/j.cell.2012.04.018
extern: '1'
external_id:
pmid:
- '22579277'
fulldoi: https://doi.org/10.1016/j.cell.2012.04.018
intvolume: ' 149'
issue: '4'
keyword:
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.cell.2012.04.018
month: '05'
oa: 1
oa_version: Published Version
page: 733-735
pmid: 1
publication: Cell
publication_identifier:
issn:
- 0092-8674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: RNP export by nuclear envelope budding
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 149
year: '2012'
...
---
_id: '11091'
abstract:
- lang: eng
text: Neoplastic cells are often characterized by specific morphological abnormalities
of the nuclear envelope (NE), which have been used for cancer diagnosis for more
than a century. The NE is a double phospholipid bilayer that encapsulates the
nuclear genome, regulates all nuclear trafficking of RNAs and proteins and prevents
the passive diffusion of macromolecules between the nucleoplasm and the cytoplasm.
Whether there is a consequence to the proper functioning of the cell and loss
of structural integrity of the nucleus remains unclear. Using live cell imaging,
we characterize a phenomenon wherein nuclei of several proliferating human cancer
cell lines become temporarily ruptured during interphase. Strikingly, NE rupturing
was associated with the mislocalization of nucleoplasmic and cytoplasmic proteins
and, in the most extreme cases, the entrapment of cytoplasmic organelles in the
nuclear interior. In addition, we observed the formation of micronuclei-like structures
during interphase and the movement of chromatin out of the nuclear space. The
frequency of these NE rupturing events was higher in cells in which the nuclear
lamina, a network of intermediate filaments providing mechanical support to the
NE, was not properly formed. Our data uncover the existence of a NE instability
that has the potential to change the genomic landscape of cancer cells.
article_processing_charge: No
article_type: original
author:
- first_name: Jesse D.
full_name: Vargas, Jesse D.
last_name: Vargas
- first_name: Emily M.
full_name: Hatch, Emily M.
last_name: Hatch
- first_name: Daniel J.
full_name: Anderson, Daniel J.
last_name: Anderson
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Vargas JD, Hatch EM, Anderson DJ, Hetzer M. Transient nuclear envelope rupturing
during interphase in human cancer cells. Nucleus. 2012;3(1):88-100. doi:10.4161/nucl.18954
apa: Vargas, J. D., Hatch, E. M., Anderson, D. J., & Hetzer, M. (2012). Transient
nuclear envelope rupturing during interphase in human cancer cells. Nucleus.
Taylor & Francis. https://doi.org/10.4161/nucl.18954
chicago: Vargas, Jesse D., Emily M. Hatch, Daniel J. Anderson, and Martin Hetzer.
“Transient Nuclear Envelope Rupturing during Interphase in Human Cancer Cells.”
Nucleus. Taylor & Francis, 2012. https://doi.org/10.4161/nucl.18954.
ieee: J. D. Vargas, E. M. Hatch, D. J. Anderson, and M. Hetzer, “Transient nuclear
envelope rupturing during interphase in human cancer cells,” Nucleus, vol.
3, no. 1. Taylor & Francis, pp. 88–100, 2012.
ista: Vargas JD, Hatch EM, Anderson DJ, Hetzer M. 2012. Transient nuclear envelope
rupturing during interphase in human cancer cells. Nucleus. 3(1), 88–100.
mla: Vargas, Jesse D., et al. “Transient Nuclear Envelope Rupturing during Interphase
in Human Cancer Cells.” Nucleus, vol. 3, no. 1, Taylor & Francis, 2012,
pp. 88–100, doi:10.4161/nucl.18954.
short: J.D. Vargas, E.M. Hatch, D.J. Anderson, M. Hetzer, Nucleus 3 (2012) 88–100.
date_created: 2022-04-07T07:51:53Z
date_published: 2012-01-01T00:00:00Z
date_updated: 2024-10-14T11:25:37Z
day: '01'
doi: 10.4161/nucl.18954
extern: '1'
external_id:
pmid:
- '22567193'
fulldoi: https://doi.org/10.4161/nucl.18954
intvolume: ' 3'
issue: '1'
keyword:
- Cell Biology
language:
- iso: eng
month: '01'
oa_version: None
page: 88-100
pmid: 1
publication: Nucleus
publication_identifier:
eissn:
- 1949-1042
issn:
- 1949-1034
publication_status: published
publisher: Taylor & Francis
quality_controlled: '1'
scopus_import: '1'
status: public
title: Transient nuclear envelope rupturing during interphase in human cancer cells
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2012'
...
---
_id: '11092'
abstract:
- lang: eng
text: To combat the functional decline of the proteome, cells use the process of
protein turnover to replace potentially impaired polypeptides with new functional
copies. We found that extremely long-lived proteins (ELLPs) did not turn over
in postmitotic cells of the rat central nervous system. These ELLPs were associated
with chromatin and the nuclear pore complex, the central transport channels that
mediate all molecular trafficking in and out of the nucleus. The longevity of
these proteins would be expected to expose them to potentially harmful metabolites,
putting them at risk of accumulating damage over extended periods of time. Thus,
it is possible that failure to maintain proper levels and functional integrity
of ELLPs in nonproliferative cells might contribute to age-related deterioration
in cell and tissue function.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Jeffrey N.
full_name: Savas, Jeffrey N.
last_name: Savas
- first_name: Brandon H.
full_name: Toyama, Brandon H.
last_name: Toyama
- first_name: Tao
full_name: Xu, Tao
last_name: Xu
- first_name: John R.
full_name: Yates, John R.
last_name: Yates
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Savas JN, Toyama BH, Xu T, Yates JR, Hetzer M. Extremely long-lived nuclear
pore proteins in the rat brain. Science. 2012;335(6071):942-942. doi:10.1126/science.1217421
apa: Savas, J. N., Toyama, B. H., Xu, T., Yates, J. R., & Hetzer, M. (2012).
Extremely long-lived nuclear pore proteins in the rat brain. Science. American
Association for the Advancement of Science. https://doi.org/10.1126/science.1217421
chicago: Savas, Jeffrey N., Brandon H. Toyama, Tao Xu, John R. Yates, and Martin
Hetzer. “Extremely Long-Lived Nuclear Pore Proteins in the Rat Brain.” Science.
American Association for the Advancement of Science, 2012. https://doi.org/10.1126/science.1217421.
ieee: J. N. Savas, B. H. Toyama, T. Xu, J. R. Yates, and M. Hetzer, “Extremely long-lived
nuclear pore proteins in the rat brain,” Science, vol. 335, no. 6071. American
Association for the Advancement of Science, pp. 942–942, 2012.
ista: Savas JN, Toyama BH, Xu T, Yates JR, Hetzer M. 2012. Extremely long-lived
nuclear pore proteins in the rat brain. Science. 335(6071), 942–942.
mla: Savas, Jeffrey N., et al. “Extremely Long-Lived Nuclear Pore Proteins in the
Rat Brain.” Science, vol. 335, no. 6071, American Association for the Advancement
of Science, 2012, pp. 942–942, doi:10.1126/science.1217421.
short: J.N. Savas, B.H. Toyama, T. Xu, J.R. Yates, M. Hetzer, Science 335 (2012)
942–942.
date_created: 2022-04-07T07:52:01Z
date_published: 2012-02-02T00:00:00Z
date_updated: 2025-12-15T10:03:06Z
day: '02'
department:
- _id: MaHe
doi: 10.1126/science.1217421
extern: '1'
external_id:
pmid:
- '22300851'
fulldoi: https://doi.org/10.1126/science.1217421
intvolume: ' 335'
issue: '6071'
language:
- iso: eng
month: '02'
oa_version: None
page: 942-942
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Extremely long-lived nuclear pore proteins in the rat brain
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 335
year: '2012'
...
---
_id: '11093'
abstract:
- lang: eng
text: Nuclear pore complexes (NPCs) are built from ∼30 different proteins called
nucleoporins or Nups. Previous studies have shown that several Nups exhibit cell-type-specific
expression and that mutations in NPC components result in tissue-specific diseases.
Here we show that a specific change in NPC composition is required for both myogenic
and neuronal differentiation. The transmembrane nucleoporin Nup210 is absent in
proliferating myoblasts and embryonic stem cells (ESCs) but becomes expressed
and incorporated into NPCs during cell differentiation. Preventing Nup210 production
by RNAi blocks myogenesis and the differentiation of ESCs into neuroprogenitors.
We found that the addition of Nup210 to NPCs does not affect nuclear transport
but is required for the induction of genes that are essential for cell differentiation.
Our results identify a single change in NPC composition as an essential step in
cell differentiation and establish a role for Nup210 in gene expression regulation
and cell fate determination.
article_processing_charge: No
article_type: original
author:
- first_name: Maximiliano A.
full_name: D'Angelo, Maximiliano A.
last_name: D'Angelo
- first_name: J. Sebastian
full_name: Gomez-Cavazos, J. Sebastian
last_name: Gomez-Cavazos
- first_name: Arianna
full_name: Mei, Arianna
last_name: Mei
- first_name: Daniel H.
full_name: Lackner, Daniel H.
last_name: Lackner
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: D’Angelo MA, Gomez-Cavazos JS, Mei A, Lackner DH, Hetzer M. A change in nuclear
pore complex composition regulates cell differentiation. Developmental Cell.
2012;22(2):446-458. doi:10.1016/j.devcel.2011.11.021
apa: D’Angelo, M. A., Gomez-Cavazos, J. S., Mei, A., Lackner, D. H., & Hetzer,
M. (2012). A change in nuclear pore complex composition regulates cell differentiation.
Developmental Cell. Elsevier. https://doi.org/10.1016/j.devcel.2011.11.021
chicago: D’Angelo, Maximiliano A., J. Sebastian Gomez-Cavazos, Arianna Mei, Daniel H.
Lackner, and Martin Hetzer. “A Change in Nuclear Pore Complex Composition Regulates
Cell Differentiation.” Developmental Cell. Elsevier, 2012. https://doi.org/10.1016/j.devcel.2011.11.021.
ieee: M. A. D’Angelo, J. S. Gomez-Cavazos, A. Mei, D. H. Lackner, and M. Hetzer,
“A change in nuclear pore complex composition regulates cell differentiation,”
Developmental Cell, vol. 22, no. 2. Elsevier, pp. 446–458, 2012.
ista: D’Angelo MA, Gomez-Cavazos JS, Mei A, Lackner DH, Hetzer M. 2012. A change
in nuclear pore complex composition regulates cell differentiation. Developmental
Cell. 22(2), 446–458.
mla: D’Angelo, Maximiliano A., et al. “A Change in Nuclear Pore Complex Composition
Regulates Cell Differentiation.” Developmental Cell, vol. 22, no. 2, Elsevier,
2012, pp. 446–58, doi:10.1016/j.devcel.2011.11.021.
short: M.A. D’Angelo, J.S. Gomez-Cavazos, A. Mei, D.H. Lackner, M. Hetzer, Developmental
Cell 22 (2012) 446–458.
date_created: 2022-04-07T07:52:10Z
date_published: 2012-01-19T00:00:00Z
date_updated: 2024-10-14T11:26:00Z
day: '19'
doi: 10.1016/j.devcel.2011.11.021
extern: '1'
external_id:
pmid:
- '22264802'
fulldoi: https://doi.org/10.1016/j.devcel.2011.11.021
intvolume: ' 22'
issue: '2'
keyword:
- Developmental Biology
- Cell Biology
- General Biochemistry
- Genetics and Molecular Biology
- Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.devcel.2011.11.021
month: '01'
oa: 1
oa_version: Published Version
page: 446-458
pmid: 1
publication: Developmental Cell
publication_identifier:
issn:
- 1534-5807
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: A change in nuclear pore complex composition regulates cell differentiation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 22
year: '2012'
...
---
_id: '113'
abstract:
- lang: eng
text: 'Although liquids typically flow around intruding objects, a counterintuitive
phenomenon occurs in dense suspensions of micrometre-sized particles: they become
liquid-like when perturbed lightly, but harden when driven strongly. Rheological
experiments have investigated how such thickening arises under shear, and linked
it to hydrodynamic interactions or granular dilation. However, neither of these
mechanisms alone can explain the ability of suspensions to generate very large,
positive normal stresses under impact. To illustrate the phenomenon, such stresses
can be large enough to allow a person to run across a suspension without sinking,
and far exceed the upper limit observed under shear or extension. Here we show
that these stresses originate from an impact-generated solidification front that
transforms an initially compressible particle matrix into a rapidly growing jammed
region, ultimately leading to extraordinary amounts of momentum absorption. Using
high-speed videography, embedded force sensing and X-ray imaging, we capture the
detailed dynamics of this process as it decelerates a metal rod hitting a suspension
of cornflour (cornstarch) in water. We develop a model for the dynamic solidification
and its effect on the surrounding suspension that reproduces the observed behaviour
quantitatively. Our findings suggest that prior interpretations of the impact
resistance as dominated by shear thickening need to be revisited.'
acknowledgement: This work was supported by NSF through its MRSEC programme (DMR-0820054)
and by the US Army Research Office through grant number W911NF-12-1-0182. S.R.W.
acknowledges support from a Millikan fellowship.
author:
- first_name: Scott R
full_name: Waitukaitis, Scott R
id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87
last_name: Waitukaitis
orcid: 0000-0002-2299-3176
- first_name: Heinrich
full_name: Jaeger, Heinrich
last_name: Jaeger
citation:
ama: Waitukaitis SR, Jaeger H. Impact-activated solidification of dense suspensions
via dynamic jamming fronts. Nature. 2012;487(7406):205-209. doi:10.1038/nature11187
apa: Waitukaitis, S. R., & Jaeger, H. (2012). Impact-activated solidification
of dense suspensions via dynamic jamming fronts. Nature. Nature Publishing
Group. https://doi.org/10.1038/nature11187
chicago: Waitukaitis, Scott R, and Heinrich Jaeger. “Impact-Activated Solidification
of Dense Suspensions via Dynamic Jamming Fronts.” Nature. Nature Publishing
Group, 2012. https://doi.org/10.1038/nature11187.
ieee: S. R. Waitukaitis and H. Jaeger, “Impact-activated solidification of dense
suspensions via dynamic jamming fronts,” Nature, vol. 487, no. 7406. Nature
Publishing Group, pp. 205–209, 2012.
ista: Waitukaitis SR, Jaeger H. 2012. Impact-activated solidification of dense suspensions
via dynamic jamming fronts. Nature. 487(7406), 205–209.
mla: Waitukaitis, Scott R., and Heinrich Jaeger. “Impact-Activated Solidification
of Dense Suspensions via Dynamic Jamming Fronts.” Nature, vol. 487, no.
7406, Nature Publishing Group, 2012, pp. 205–09, doi:10.1038/nature11187.
short: S.R. Waitukaitis, H. Jaeger, Nature 487 (2012) 205–209.
date_created: 2018-12-11T11:44:42Z
date_published: 2012-07-12T00:00:00Z
date_updated: 2021-01-12T06:48:30Z
day: '12'
doi: 10.1038/nature11187
extern: '1'
fulldoi: https://doi.org/10.1038/nature11187
intvolume: ' 487'
issue: '7406'
language:
- iso: eng
month: '07'
oa_version: None
page: 205 - 209
publication: Nature
publication_status: published
publisher: Nature Publishing Group
publist_id: '7941'
status: public
title: Impact-activated solidification of dense suspensions via dynamic jamming fronts
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 487
year: '2012'
...
---
_id: '114'
abstract:
- lang: eng
text: We report on an investigation of the solidification of a cornstarch and water
suspension during normal impact on its surface. We find that a finite time after
impact, the suspension displays characteristics reminiscent of a solid, including
localized stress transmission, the development of a yield stress, and some elastic
energy storage. The time dependence of these characteristics depends on the thickness
of the cornstarch layer, showing that the solidification is a dynamic process
driven by the impacting object. These findings confirm previous speculations that
rapidly applied normal stress transforms the normally fluid-like suspension into
a temporarily jammed solid and draw a clear distinction between the effects of
normal stress and shear stress in dense suspensions.
acknowledgement: This work was supported by the NSF through its MRSEC program (DMR-0820054).
S. R. W. acknowledges support from a Millikan fellowship.
author:
- first_name: Scott R
full_name: Waitukaitis, Scott R
id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87
last_name: Waitukaitis
orcid: 0000-0002-2299-3176
- first_name: Heinrich
full_name: Jaeger, Heinrich
last_name: Jaeger
citation:
ama: Waitukaitis SR, Jaeger H. Solidification of a cornstarch and water suspension.
Revista Cubana de Fisica. 2012;29(1E):1E31-1E33.
apa: Waitukaitis, S. R., & Jaeger, H. (2012). Solidification of a cornstarch
and water suspension. Revista Cubana de Fisica. Universidad de La Habana.
chicago: Waitukaitis, Scott R, and Heinrich Jaeger. “Solidification of a Cornstarch
and Water Suspension.” Revista Cubana de Fisica. Universidad de La Habana,
2012.
ieee: S. R. Waitukaitis and H. Jaeger, “Solidification of a cornstarch and water
suspension,” Revista Cubana de Fisica, vol. 29, no. 1E. Universidad de
La Habana, p. 1E31-1E33, 2012.
ista: Waitukaitis SR, Jaeger H. 2012. Solidification of a cornstarch and water suspension.
Revista Cubana de Fisica. 29(1E), 1E31-1E33.
mla: Waitukaitis, Scott R., and Heinrich Jaeger. “Solidification of a Cornstarch
and Water Suspension.” Revista Cubana de Fisica, vol. 29, no. 1E, Universidad
de La Habana, 2012, p. 1E31-1E33.
short: S.R. Waitukaitis, H. Jaeger, Revista Cubana de Fisica 29 (2012) 1E31-1E33.
date_created: 2018-12-11T11:44:42Z
date_published: 2012-08-14T00:00:00Z
date_updated: 2021-01-12T06:48:34Z
day: '14'
ddc:
- '530'
extern: '1'
file:
- access_level: open_access
content_type: application/pdf
creator: kschuh
date_created: 2019-05-16T11:08:52Z
date_updated: 2019-05-16T11:08:52Z
file_id: '6461'
file_name: 2012_RCF_Waitukaitis.pdf
file_size: 589776
relation: main_file
success: 1
file_date_updated: 2019-05-16T11:08:52Z
has_accepted_license: '1'
intvolume: ' 29'
issue: 1E
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '08'
oa: 1
oa_version: Published Version
page: 1E31 - 1E33
publication: Revista Cubana de Fisica
publication_status: published
publisher: Universidad de La Habana
publist_id: '7940'
quality_controlled: '1'
status: public
title: Solidification of a cornstarch and water suspension
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 29
year: '2012'
...
---
_id: '11656'
abstract:
- lang: eng
text: "Suppose your sole interest in recommending a product to me is to maximize
the amount paid to you by the seller for a sequence of recommendations. How should
you recommend optimally if I become more inclined to ignore you with each irrelevant
recommendation you make? Finding an answer to this question is a key challenge
in all forms of marketing that rely on and explore social ties; ranging from personal
recommendations to viral marketing.\r\n\r\nWe prove that even if the recommendee
regains her initial trust on each successful recommendation, the expected revenue
the recommender can make over an infinite period due to payments by the seller
is bounded. This can only be overcome when the recommendee also incrementally
regains trust during periods without any recommendation. Here, we see a connection
to \"banner blindness,\" suggesting that showing fewer ads can lead to a higher
long-term revenue."
article_processing_charge: No
author:
- first_name: Paul
full_name: Dütting, Paul
last_name: Dütting
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Ingmar
full_name: Weber, Ingmar
last_name: Weber
citation:
ama: 'Dütting P, Henzinger M, Weber I. Maximizing revenue from strategic recommendations
under decaying trust. In: Proceedings of the 21st ACM International Conference
on Information and Knowledge Management. Association for Computing Machinery;
2012:2268-2286. doi:10.1145/2396761.2398621'
apa: 'Dütting, P., Henzinger, M., & Weber, I. (2012). Maximizing revenue from
strategic recommendations under decaying trust. In Proceedings of the 21st
ACM international conference on Information and knowledge management (pp.
2268–2286). Maui, HI, United States: Association for Computing Machinery. https://doi.org/10.1145/2396761.2398621'
chicago: Dütting, Paul, Monika Henzinger, and Ingmar Weber. “Maximizing Revenue
from Strategic Recommendations under Decaying Trust.” In Proceedings of the
21st ACM International Conference on Information and Knowledge Management,
2268–86. Association for Computing Machinery, 2012. https://doi.org/10.1145/2396761.2398621.
ieee: P. Dütting, M. Henzinger, and I. Weber, “Maximizing revenue from strategic
recommendations under decaying trust,” in Proceedings of the 21st ACM international
conference on Information and knowledge management, Maui, HI, United States,
2012, pp. 2268–2286.
ista: 'Dütting P, Henzinger M, Weber I. 2012. Maximizing revenue from strategic
recommendations under decaying trust. Proceedings of the 21st ACM international
conference on Information and knowledge management. CIKM: Conference on Information
and Knowledge Management, 2268–2286.'
mla: Dütting, Paul, et al. “Maximizing Revenue from Strategic Recommendations under
Decaying Trust.” Proceedings of the 21st ACM International Conference on Information
and Knowledge Management, Association for Computing Machinery, 2012, pp. 2268–86,
doi:10.1145/2396761.2398621.
short: P. Dütting, M. Henzinger, I. Weber, in:, Proceedings of the 21st ACM International
Conference on Information and Knowledge Management, Association for Computing
Machinery, 2012, pp. 2268–2286.
conference:
end_date: 2012-11-02
location: Maui, HI, United States
name: 'CIKM: Conference on Information and Knowledge Management'
start_date: 2012-10-29
date_created: 2022-07-27T06:47:53Z
date_published: 2012-10-29T00:00:00Z
date_updated: 2024-11-06T12:05:11Z
day: '29'
doi: 10.1145/2396761.2398621
extern: '1'
fulldoi: https://doi.org/10.1145/2396761.2398621
language:
- iso: eng
month: '10'
oa_version: None
page: 2268-2286
publication: Proceedings of the 21st ACM international conference on Information and
knowledge management
publication_identifier:
isbn:
- '9781450311564'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Maximizing revenue from strategic recommendations under decaying trust
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2012'
...
---
_id: '11751'
abstract:
- lang: eng
text: The Seebeck coefficients, electrical resistivities, total thermal conductivities,
and magnetization are reported for temperatures between 5 and 350 K for n-type
Bi0.88Sb0.12 nano-composite alloys made by Ho-doping at the 0, 1, and 3 % atomic
levels. The alloys were prepared using a dc hot-pressing method, and are shown
to be single phase for both Ho contents with grain sizes on the average of 900
nm. We find the parent compound has a maximum of ZT = 0.28 at 231 K, while doping
1 % Ho increases the maximum ZT to 0.31 at 221 K and the 3 % doped sample suppresses
the maximum ZT = 0.24 at a temperature of 260 K.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: K. C.
full_name: Lukas, K. C.
last_name: Lukas
- first_name: G.
full_name: Joshi, G.
last_name: Joshi
- first_name: Kimberly A
full_name: Modic, Kimberly A
id: 13C26AC0-EB69-11E9-87C6-5F3BE6697425
last_name: Modic
orcid: 0000-0001-9760-3147
- first_name: Z. F.
full_name: Ren, Z. F.
last_name: Ren
- first_name: C. P.
full_name: Opeil, C. P.
last_name: Opeil
citation:
ama: Lukas KC, Joshi G, Modic KA, Ren ZF, Opeil CP. Thermoelectric properties of
Ho-doped Bi0.88Sb0.12. Journal of Materials Science. 2012;47(15):5729-5734.
doi:10.1007/s10853-012-6463-6
apa: Lukas, K. C., Joshi, G., Modic, K. A., Ren, Z. F., & Opeil, C. P. (2012).
Thermoelectric properties of Ho-doped Bi0.88Sb0.12. Journal of Materials Science.
Springer Nature. https://doi.org/10.1007/s10853-012-6463-6
chicago: Lukas, K. C., G. Joshi, Kimberly A Modic, Z. F. Ren, and C. P. Opeil. “Thermoelectric
Properties of Ho-Doped Bi0.88Sb0.12.” Journal of Materials Science. Springer
Nature, 2012. https://doi.org/10.1007/s10853-012-6463-6.
ieee: K. C. Lukas, G. Joshi, K. A. Modic, Z. F. Ren, and C. P. Opeil, “Thermoelectric
properties of Ho-doped Bi0.88Sb0.12,” Journal of Materials Science, vol.
47, no. 15. Springer Nature, pp. 5729–5734, 2012.
ista: Lukas KC, Joshi G, Modic KA, Ren ZF, Opeil CP. 2012. Thermoelectric properties
of Ho-doped Bi0.88Sb0.12. Journal of Materials Science. 47(15), 5729–5734.
mla: Lukas, K. C., et al. “Thermoelectric Properties of Ho-Doped Bi0.88Sb0.12.”
Journal of Materials Science, vol. 47, no. 15, Springer Nature, 2012, pp.
5729–34, doi:10.1007/s10853-012-6463-6.
short: K.C. Lukas, G. Joshi, K.A. Modic, Z.F. Ren, C.P. Opeil, Journal of Materials
Science 47 (2012) 5729–5734.
date_created: 2022-08-08T08:28:20Z
date_published: 2012-08-01T00:00:00Z
date_updated: 2022-08-11T09:34:39Z
day: '01'
doi: 10.1007/s10853-012-6463-6
extern: '1'
external_id:
arxiv:
- '1201.6304'
fulldoi: https://doi.org/10.1007/s10853-012-6463-6
intvolume: ' 47'
issue: '15'
language:
- iso: eng
month: '08'
oa_version: Preprint
page: 5729-5734
publication: Journal of Materials Science
publication_identifier:
eissn:
- 1573-4803
issn:
- 0022-2461
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Thermoelectric properties of Ho-doped Bi0.88Sb0.12
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 47
year: '2012'
...