---
_id: '2974'
abstract:
- lang: eng
text: "We construct a perfectly binding string commitment scheme whose security
is based on the learning parity with noise (LPN) assumption, or equivalently,
the hardness of decoding random linear codes. Our scheme not only allows for a
simple and efficient zero-knowledge proof of knowledge for committed values (essentially
a Σ-protocol), but also for such proofs showing any kind of relation amongst committed
values, i.e. proving that messages m_0,...,m_u, are such that m_0=C(m_1,...,m_u)
for any circuit C.\r\n\r\nTo get soundness which is exponentially small in a security
parameter t, and when the zero-knowledge property relies on the LPN problem with
secrets of length l, our 3 round protocol has communication complexity O(t|C|l
log(l)) and computational complexity of O(t|C|l) bit operations. The hidden constants
are small, and the computation consists mostly of computing inner products of
bit-vectors."
acknowledgement: "We are grateful to Petros Mol for helpful discussions on the reduction
for the hardness of the xLPN problem.\r\n"
alternative_title:
- LNCS
author:
- first_name: Abhishek
full_name: Jain, Abhishek
last_name: Jain
- first_name: Stephan
full_name: Krenn, Stephan
id: 329FCCF0-F248-11E8-B48F-1D18A9856A87
last_name: Krenn
orcid: 0000-0003-2835-9093
- first_name: Krzysztof Z
full_name: Pietrzak, Krzysztof Z
id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
last_name: Pietrzak
orcid: 0000-0002-9139-1654
- first_name: Aris
full_name: Tentes, Aris
last_name: Tentes
citation:
ama: 'Jain A, Krenn S, Pietrzak KZ, Tentes A. Commitments and efficient zero knowledge
proofs from learning parity with noise. In: Wang X, Sako K, eds. Vol 7658. Springer;
2012:663-680. doi:10.1007/978-3-642-34961-4_40'
apa: 'Jain, A., Krenn, S., Pietrzak, K. Z., & Tentes, A. (2012). Commitments
and efficient zero knowledge proofs from learning parity with noise. In X. Wang
& K. Sako (Eds.) (Vol. 7658, pp. 663–680). Presented at the ASIACRYPT: Theory
and Application of Cryptology and Information Security, Beijing, China: Springer.
https://doi.org/10.1007/978-3-642-34961-4_40'
chicago: Jain, Abhishek, Stephan Krenn, Krzysztof Z Pietrzak, and Aris Tentes. “Commitments
and Efficient Zero Knowledge Proofs from Learning Parity with Noise.” edited by
Xiaoyun Wang and Kazue Sako, 7658:663–80. Springer, 2012. https://doi.org/10.1007/978-3-642-34961-4_40.
ieee: 'A. Jain, S. Krenn, K. Z. Pietrzak, and A. Tentes, “Commitments and efficient
zero knowledge proofs from learning parity with noise,” presented at the ASIACRYPT:
Theory and Application of Cryptology and Information Security, Beijing, China,
2012, vol. 7658, pp. 663–680.'
ista: 'Jain A, Krenn S, Pietrzak KZ, Tentes A. 2012. Commitments and efficient zero
knowledge proofs from learning parity with noise. ASIACRYPT: Theory and Application
of Cryptology and Information Security, LNCS, vol. 7658, 663–680.'
mla: Jain, Abhishek, et al. Commitments and Efficient Zero Knowledge Proofs from
Learning Parity with Noise. Edited by Xiaoyun Wang and Kazue Sako, vol. 7658,
Springer, 2012, pp. 663–80, doi:10.1007/978-3-642-34961-4_40.
short: A. Jain, S. Krenn, K.Z. Pietrzak, A. Tentes, in:, X. Wang, K. Sako (Eds.),
Springer, 2012, pp. 663–680.
conference:
end_date: 2012-12-06
location: Beijing, China
name: 'ASIACRYPT: Theory and Application of Cryptology and Information Security'
start_date: 2012-12-02
date_created: 2018-12-11T12:00:38Z
date_published: 2012-12-01T00:00:00Z
date_updated: 2021-01-12T07:40:11Z
day: '01'
ddc:
- '004'
- '005'
department:
- _id: KrPi
doi: 10.1007/978-3-642-34961-4_40
ec_funded: 1
editor:
- first_name: Xiaoyun
full_name: Wang, Xiaoyun
last_name: Wang
- first_name: Kazue
full_name: Sako, Kazue
last_name: Sako
file:
- access_level: open_access
checksum: ab879537385efc4cb4203e7ef0fea17b
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:14:00Z
date_updated: 2020-07-14T12:45:58Z
file_id: '5048'
file_name: IST-2016-721-v1+1_513.pdf
file_size: 482570
relation: main_file
file_date_updated: 2020-07-14T12:45:58Z
fulldoi: https://doi.org/10.1007/978-3-642-34961-4_40
has_accepted_license: '1'
intvolume: ' 7658'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Submitted Version
page: 663 - 680
project:
- _id: 258C570E-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '259668'
name: Provable Security for Physical Cryptography
publication_status: published
publisher: Springer
publist_id: '3730'
pubrep_id: '721'
scopus_import: 1
status: public
title: Commitments and efficient zero knowledge proofs from learning parity with noise
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 7658
year: '2012'
...
---
_id: '12198'
abstract:
- lang: eng
text: The Arabidopsis thaliana central cell, the companion cell of the egg, undergoes
DNA demethylation before fertilization, but the targeting preferences, mechanism,
and biological significance of this process remain unclear. Here, we show that
active DNA demethylation mediated by the DEMETER DNA glycosylase accounts for
all of the demethylation in the central cell and preferentially targets small,
AT-rich, and nucleosome-depleted euchromatic transposable elements. The vegetative
cell, the companion cell of sperm, also undergoes DEMETER-dependent demethylation
of similar sequences, and lack of DEMETER in vegetative cells causes reduced small
RNA–directed DNA methylation of transposons in sperm. Our results demonstrate
that demethylation in companion cells reinforces transposon methylation in plant
gametes and likely contributes to stable silencing of transposable elements across
generations.
acknowledgement: We thank S. Harmer for assistance with the analysis of histone modifications,
the BioOptics team at the Vienna Biocenter Campus for sorting sperm and vegetative
cell nuclei, K. Slotkin for the LAT52p-amiRNA=GFP plasmid, and G. Drews for the
DD45p-GFP transgenic line. This work was partially funded by an NIH grant (GM69415)
to R.L.F., NSF grants (MCB-0918821 and IOS-1025890) to R.L.F. and D.Z., a Young
Investigator Grant from the Arnold and Mabel Beckman Foundation to D.Z., an Austrian
Science Fund (FWF) grant P21389-B03 to H.T., a Ruth L. Kirschstein NIH Predoctoral
Fellowship (GM093633) to C.A.I., a Fulbright Scholarship to J.A.R., a fellowship
from the Jane Coffin Childs Memorial Fund to A.Z., and a Robert and Colleen Haas
Scholarship to D.R. Sequencing data are deposited in GEO (GSE38935).
article_processing_charge: No
article_type: original
author:
- first_name: Christian A.
full_name: Ibarra, Christian A.
last_name: Ibarra
- first_name: Xiaoqi
full_name: Feng, Xiaoqi
id: e0164712-22ee-11ed-b12a-d80fcdf35958
last_name: Feng
orcid: 0000-0002-4008-1234
- first_name: Vera K.
full_name: Schoft, Vera K.
last_name: Schoft
- first_name: Tzung-Fu
full_name: Hsieh, Tzung-Fu
last_name: Hsieh
- first_name: Rie
full_name: Uzawa, Rie
last_name: Uzawa
- first_name: Jessica A.
full_name: Rodrigues, Jessica A.
last_name: Rodrigues
- first_name: Assaf
full_name: Zemach, Assaf
last_name: Zemach
- first_name: Nina
full_name: Chumak, Nina
last_name: Chumak
- first_name: Adriana
full_name: Machlicova, Adriana
last_name: Machlicova
- first_name: Toshiro
full_name: Nishimura, Toshiro
last_name: Nishimura
- first_name: Denisse
full_name: Rojas, Denisse
last_name: Rojas
- first_name: Robert L.
full_name: Fischer, Robert L.
last_name: Fischer
- first_name: Hisashi
full_name: Tamaru, Hisashi
last_name: Tamaru
- first_name: Daniel
full_name: Zilberman, Daniel
id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
last_name: Zilberman
orcid: 0000-0002-0123-8649
citation:
ama: Ibarra CA, Feng X, Schoft VK, et al. Active DNA demethylation in plant companion
cells reinforces transposon methylation in gametes. Science. 2012;337(6100):1360-1364.
doi:10.1126/science.1224839
apa: Ibarra, C. A., Feng, X., Schoft, V. K., Hsieh, T.-F., Uzawa, R., Rodrigues,
J. A., … Zilberman, D. (2012). Active DNA demethylation in plant companion cells
reinforces transposon methylation in gametes. Science. American Association
for the Advancement of Science. https://doi.org/10.1126/science.1224839
chicago: Ibarra, Christian A., Xiaoqi Feng, Vera K. Schoft, Tzung-Fu Hsieh, Rie
Uzawa, Jessica A. Rodrigues, Assaf Zemach, et al. “Active DNA Demethylation in
Plant Companion Cells Reinforces Transposon Methylation in Gametes.” Science.
American Association for the Advancement of Science, 2012. https://doi.org/10.1126/science.1224839.
ieee: C. A. Ibarra et al., “Active DNA demethylation in plant companion cells
reinforces transposon methylation in gametes,” Science, vol. 337, no. 6100.
American Association for the Advancement of Science, pp. 1360–1364, 2012.
ista: Ibarra CA, Feng X, Schoft VK, Hsieh T-F, Uzawa R, Rodrigues JA, Zemach A,
Chumak N, Machlicova A, Nishimura T, Rojas D, Fischer RL, Tamaru H, Zilberman
D. 2012. Active DNA demethylation in plant companion cells reinforces transposon
methylation in gametes. Science. 337(6100), 1360–1364.
mla: Ibarra, Christian A., et al. “Active DNA Demethylation in Plant Companion Cells
Reinforces Transposon Methylation in Gametes.” Science, vol. 337, no. 6100,
American Association for the Advancement of Science, 2012, pp. 1360–64, doi:10.1126/science.1224839.
short: C.A. Ibarra, X. Feng, V.K. Schoft, T.-F. Hsieh, R. Uzawa, J.A. Rodrigues,
A. Zemach, N. Chumak, A. Machlicova, T. Nishimura, D. Rojas, R.L. Fischer, H.
Tamaru, D. Zilberman, Science 337 (2012) 1360–1364.
date_created: 2023-01-16T09:21:24Z
date_published: 2012-09-14T00:00:00Z
date_updated: 2025-01-14T12:37:28Z
day: '14'
department:
- _id: XiFe
doi: 10.1126/science.1224839
extern: '1'
external_id:
pmid:
- '22984074'
fulldoi: https://doi.org/10.1126/science.1224839
intvolume: ' 337'
issue: '6100'
keyword:
- Multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034762/
month: '09'
oa: 1
oa_version: Published Version
page: 1360-1364
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Active DNA demethylation in plant companion cells reinforces transposon methylation
in gametes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 337
year: '2012'
...
---
_id: '12644'
abstract:
- lang: eng
text: In the Dry Andes of central Chile, summer water resources originate mostly
from snowmelt and ice melt. We use the physically based, spatially distributed
hydrological model TOPKAPI to study the exchange between glaciers and climate
in the upper Aconcagua River Basin during the summer season and identify the model
parameters that are robust and transferable and those that are more dependent
on calibration. TOPKAPI has recently been adapted to incorporate an enhanced temperature
index approach for snow and ice melting. We suggest a calibration procedure that
allows calibration of parameters in three steps by separating parameters governing
distinct processes. We evaluate the parameters' transferability in time and in
space by applying the model at two spatial scales. TOPKAPI's ability to simulate
the relevant processes is tested against meteorological, ablation, and glacier
runoff data measured on Juncal Norte Glacier during two glacier ablation seasons.
The model was applied successfully to the climatic setting of the Dry Andes once
its parameters were recalibrated. We found a clear distinction between parameters
that are stable in time and those that need recalibration. The parameters of the
melt model are transferable from one season to the other, while the parameters
governing the extrapolation of meteorological input data and the routing of glacier
meltwater need recalibration from one season to the other. Sensitivity analysis
revealed that the model is most sensitive to the temperature lapse rate governing
the extrapolation of air temperature from point measurements to the glacier scale
and to the melt parameter that multiplies the shortwave radiation balance.
article_number: W03509
article_processing_charge: No
article_type: original
author:
- first_name: S.
full_name: Ragettli, S.
last_name: Ragettli
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
citation:
ama: 'Ragettli S, Pellicciotti F. Calibration of a physically based, spatially distributed
hydrological model in a glacierized basin: On the use of knowledge from glaciometeorological
processes to constrain model parameters. Water Resources Research. 2012;48(3).
doi:10.1029/2011wr010559'
apa: 'Ragettli, S., & Pellicciotti, F. (2012). Calibration of a physically based,
spatially distributed hydrological model in a glacierized basin: On the use of
knowledge from glaciometeorological processes to constrain model parameters. Water
Resources Research. American Geophysical Union. https://doi.org/10.1029/2011wr010559'
chicago: 'Ragettli, S., and Francesca Pellicciotti. “Calibration of a Physically
Based, Spatially Distributed Hydrological Model in a Glacierized Basin: On the
Use of Knowledge from Glaciometeorological Processes to Constrain Model Parameters.”
Water Resources Research. American Geophysical Union, 2012. https://doi.org/10.1029/2011wr010559.'
ieee: 'S. Ragettli and F. Pellicciotti, “Calibration of a physically based, spatially
distributed hydrological model in a glacierized basin: On the use of knowledge
from glaciometeorological processes to constrain model parameters,” Water Resources
Research, vol. 48, no. 3. American Geophysical Union, 2012.'
ista: 'Ragettli S, Pellicciotti F. 2012. Calibration of a physically based, spatially
distributed hydrological model in a glacierized basin: On the use of knowledge
from glaciometeorological processes to constrain model parameters. Water Resources
Research. 48(3), W03509.'
mla: 'Ragettli, S., and Francesca Pellicciotti. “Calibration of a Physically Based,
Spatially Distributed Hydrological Model in a Glacierized Basin: On the Use of
Knowledge from Glaciometeorological Processes to Constrain Model Parameters.”
Water Resources Research, vol. 48, no. 3, W03509, American Geophysical
Union, 2012, doi:10.1029/2011wr010559.'
short: S. Ragettli, F. Pellicciotti, Water Resources Research 48 (2012).
date_created: 2023-02-20T08:17:39Z
date_published: 2012-03-01T00:00:00Z
date_updated: 2023-02-21T09:38:36Z
day: '01'
doi: 10.1029/2011wr010559
extern: '1'
fulldoi: https://doi.org/10.1029/2011wr010559
intvolume: ' 48'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1029/2011WR010559
month: '03'
oa: 1
oa_version: Published Version
publication: Water Resources Research
publication_identifier:
issn:
- 0043-1397
publication_status: published
publisher: American Geophysical Union
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Calibration of a physically based, spatially distributed hydrological model
in a glacierized basin: On the use of knowledge from glaciometeorological processes
to constrain model parameters'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 48
year: '2012'
...
---
_id: '12646'
abstract:
- lang: eng
text: Assessment of water resources from remote mountainous catchments plays a crucial
role for the development of rural areas in or in the vicinity of mountain ranges.
The scarcity of data, however, prevents the application of standard approaches
that are based on data-driven models. The Hindu Kush–Karakoram–Himalaya mountain
range is a crucial area in terms of water resources, but our understanding of
the response of its high-elevation catchments to a changing climate is hindered
by lack of hydro-meteorological and cryospheric data. Hydrological modeling is
challenging here because internal inconsistencies—such as an underestimation of
precipitation input that can be compensated for by an overestimation of meltwater—might
be hidden due to the complexity of feedback mechanisms that govern melt and runoff
generation in such basins. Data scarcity adds to this difficulty by preventing
the application of systematic calibration procedures that would allow identification
of the parameter set that could guarantee internal consistency in the simulation
of the single hydrological components. In this work, we use simulations from the
Hunza River Basin in the Karakoram region obtained with the hydrological model
TOPKAPI to quantify the predictive power of discharge and snow-cover data sets,
as well as the combination of both. We also show that short-term measurements
of meteorological variables such as radiative fluxes, wind speed, relative humidity,
and air temperature from glacio-meteorological experiments are crucial for a correct
parameterization of surface melt processes. They enable detailed simulations of
the energy fluxes governing glacier–atmosphere interaction and the resulting ablation
through energy-balance modeling. These simulations are used to derive calibrated
parameters for the simplified snow and glacier routines in TOPKAPI. We demonstrate
that such parameters are stable in space and time in similar climatic regions,
thus reducing the number of parameters requiring calibration.
article_processing_charge: No
article_type: original
author:
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
orcid: 0000-0002-5554-8087
- first_name: Cyrill
full_name: Buergi, Cyrill
last_name: Buergi
- first_name: Walter Willem
full_name: Immerzeel, Walter Willem
last_name: Immerzeel
- first_name: Markus
full_name: Konz, Markus
last_name: Konz
- first_name: Arun B.
full_name: Shrestha, Arun B.
last_name: Shrestha
citation:
ama: 'Pellicciotti F, Buergi C, Immerzeel WW, Konz M, Shrestha AB. Challenges and
uncertainties in hydrological modeling of remote Hindu Kush–Karakoram–Himalayan
(HKH) basins: Suggestions for calibration strategies. Mountain Research and
Development. 2012;32(1):39-50. doi:10.1659/mrd-journal-d-11-00092.1'
apa: 'Pellicciotti, F., Buergi, C., Immerzeel, W. W., Konz, M., & Shrestha,
A. B. (2012). Challenges and uncertainties in hydrological modeling of remote
Hindu Kush–Karakoram–Himalayan (HKH) basins: Suggestions for calibration strategies.
Mountain Research and Development. International Mountain Society. https://doi.org/10.1659/mrd-journal-d-11-00092.1'
chicago: 'Pellicciotti, Francesca, Cyrill Buergi, Walter Willem Immerzeel, Markus
Konz, and Arun B. Shrestha. “Challenges and Uncertainties in Hydrological Modeling
of Remote Hindu Kush–Karakoram–Himalayan (HKH) Basins: Suggestions for Calibration
Strategies.” Mountain Research and Development. International Mountain
Society, 2012. https://doi.org/10.1659/mrd-journal-d-11-00092.1.'
ieee: 'F. Pellicciotti, C. Buergi, W. W. Immerzeel, M. Konz, and A. B. Shrestha,
“Challenges and uncertainties in hydrological modeling of remote Hindu Kush–Karakoram–Himalayan
(HKH) basins: Suggestions for calibration strategies,” Mountain Research and
Development, vol. 32, no. 1. International Mountain Society, pp. 39–50, 2012.'
ista: 'Pellicciotti F, Buergi C, Immerzeel WW, Konz M, Shrestha AB. 2012. Challenges
and uncertainties in hydrological modeling of remote Hindu Kush–Karakoram–Himalayan
(HKH) basins: Suggestions for calibration strategies. Mountain Research and Development.
32(1), 39–50.'
mla: 'Pellicciotti, Francesca, et al. “Challenges and Uncertainties in Hydrological
Modeling of Remote Hindu Kush–Karakoram–Himalayan (HKH) Basins: Suggestions for
Calibration Strategies.” Mountain Research and Development, vol. 32, no.
1, International Mountain Society, 2012, pp. 39–50, doi:10.1659/mrd-journal-d-11-00092.1.'
short: F. Pellicciotti, C. Buergi, W.W. Immerzeel, M. Konz, A.B. Shrestha, Mountain
Research and Development 32 (2012) 39–50.
date_created: 2023-02-20T08:17:47Z
date_published: 2012-02-01T00:00:00Z
date_updated: 2024-10-14T12:01:31Z
day: '01'
doi: 10.1659/mrd-journal-d-11-00092.1
extern: '1'
fulldoi: https://doi.org/10.1659/mrd-journal-d-11-00092.1
intvolume: ' 32'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1659/MRD-JOURNAL-D-11-00092.1
month: '02'
oa: 1
oa_version: Published Version
page: 39-50
publication: Mountain Research and Development
publication_identifier:
eissn:
- 1994-7151
issn:
- 0276-4741
publication_status: published
publisher: International Mountain Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Challenges and uncertainties in hydrological modeling of remote Hindu Kush–Karakoram–Himalayan
(HKH) basins: Suggestions for calibration strategies'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 32
year: '2012'
...
---
_id: '12647'
abstract:
- lang: eng
text: Accurate quantification of the spatial distribution of precipitation in mountain
regions is crucial for assessments of water resources and for the understanding
of high-altitude hydrology, yet it is one of the largest unknowns due to the lack
of high-altitude observations. The Hunza basin in Pakistan contains very large
glacier systems, which, given the melt, cannot persist unless precipitation (snow
input) is much higher than what is observed at the meteorological stations, mostly
located in mountain valleys. Several studies, therefore, suggest strong positive
vertical precipitation lapse rates; in the present study, we quantify this lapse
rate by using glaciers as a proxy. We assume a neutral mass balance for the glaciers
for the period from 2001 to 2003, and we inversely model the precipitation lapse
by balancing the total accumulation in the catchment area and the ablation over
the glacier area for the 50 largest glacier systems in the Hunza basin in the
Karakoram. Our results reveal a vertical precipitation lapse rate that equals
0.21 ± 0.12% m−1, with a maximum precipitation at an elevation of 5500 masl. We
showed that the total annual basin precipitation (828 mm) is 260% higher than
what is estimated based on interpolated observations (319 mm); this has major
consequences for hydrological modeling and water resource assessments in general.
Our results were validated by using previously published studies on individual
glaciers as well as the water balance of the Hunza basin. The approach is more
widely applicable in mountain ranges where precipitation measurements at high
altitude are lacking.
article_processing_charge: No
article_type: original
author:
- first_name: Walter Willem
full_name: Immerzeel, Walter Willem
last_name: Immerzeel
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
- first_name: Arun B.
full_name: Shrestha, Arun B.
last_name: Shrestha
citation:
ama: Immerzeel WW, Pellicciotti F, Shrestha AB. Glaciers as a proxy to quantify
the spatial distribution of precipitation in the Hunza basin. Mountain Research
and Development. 2012;32(1):30-38. doi:10.1659/mrd-journal-d-11-00097.1
apa: Immerzeel, W. W., Pellicciotti, F., & Shrestha, A. B. (2012). Glaciers
as a proxy to quantify the spatial distribution of precipitation in the Hunza
basin. Mountain Research and Development. International Mountain Society.
https://doi.org/10.1659/mrd-journal-d-11-00097.1
chicago: Immerzeel, Walter Willem, Francesca Pellicciotti, and Arun B. Shrestha.
“Glaciers as a Proxy to Quantify the Spatial Distribution of Precipitation in
the Hunza Basin.” Mountain Research and Development. International Mountain
Society, 2012. https://doi.org/10.1659/mrd-journal-d-11-00097.1.
ieee: W. W. Immerzeel, F. Pellicciotti, and A. B. Shrestha, “Glaciers as a proxy
to quantify the spatial distribution of precipitation in the Hunza basin,” Mountain
Research and Development, vol. 32, no. 1. International Mountain Society,
pp. 30–38, 2012.
ista: Immerzeel WW, Pellicciotti F, Shrestha AB. 2012. Glaciers as a proxy to quantify
the spatial distribution of precipitation in the Hunza basin. Mountain Research
and Development. 32(1), 30–38.
mla: Immerzeel, Walter Willem, et al. “Glaciers as a Proxy to Quantify the Spatial
Distribution of Precipitation in the Hunza Basin.” Mountain Research and Development,
vol. 32, no. 1, International Mountain Society, 2012, pp. 30–38, doi:10.1659/mrd-journal-d-11-00097.1.
short: W.W. Immerzeel, F. Pellicciotti, A.B. Shrestha, Mountain Research and Development
32 (2012) 30–38.
date_created: 2023-02-20T08:17:52Z
date_published: 2012-02-01T00:00:00Z
date_updated: 2023-02-21T08:56:29Z
day: '01'
doi: 10.1659/mrd-journal-d-11-00097.1
extern: '1'
fulldoi: https://doi.org/10.1659/mrd-journal-d-11-00097.1
intvolume: ' 32'
issue: '1'
keyword:
- General Environmental Science
- Development
- Environmental Chemistry
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1659/MRD-JOURNAL-D-11-00097.1
month: '02'
oa: 1
oa_version: Published Version
page: 30-38
publication: Mountain Research and Development
publication_identifier:
eissn:
- 1994-7151
issn:
- 0276-4741
publication_status: published
publisher: International Mountain Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Glaciers as a proxy to quantify the spatial distribution of precipitation in
the Hunza basin
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 32
year: '2012'
...
---
_id: '12648'
abstract:
- lang: eng
text: Distributed glacier melt models generally assume that the glacier surface
consists of bare exposed ice and snow. In reality, many glaciers are wholly or
partially covered in layers of debris that tend to suppress ablation rates. In
this paper, an existing physically based point model for the ablation of debris-covered
ice is incorporated in a distributed melt model and applied to Haut Glacier d'Arolla,
Switzerland, which has three large patches of debris cover on its surface. The
model is based on a 10 m resolution digital elevation model (DEM) of the area;
each glacier pixel in the DEM is defined as either bare or debris-covered ice,
and may be covered in snow that must be melted off before ice ablation is assumed
to occur. Each debris-covered pixel is assigned a debris thickness value using
probability distributions based on over 1000 manual thickness measurements. Locally
observed meteorological data are used to run energy balance calculations in every
pixel, using an approach suitable for snow, bare ice or debris-covered ice as
appropriate. The use of the debris model significantly reduces the total ablation
in the debris-covered areas, however the precise reduction is sensitive to the
temperature extrapolation used in the model distribution because air near the
debris surface tends to be slightly warmer than over bare ice. Overall results
suggest that the debris patches, which cover 10% of the glacierized area, reduce
total runoff from the glacierized part of the basin by up to 7%.
article_number: D18105
article_processing_charge: No
article_type: original
author:
- first_name: T. D.
full_name: Reid, T. D.
last_name: Reid
- first_name: M.
full_name: Carenzo, M.
last_name: Carenzo
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
- first_name: B. W.
full_name: Brock, B. W.
last_name: Brock
citation:
ama: 'Reid TD, Carenzo M, Pellicciotti F, Brock BW. Including debris cover effects
in a distributed model of glacier ablation. Journal of Geophysical Research:
Atmospheres. 2012;117(D18). doi:10.1029/2012jd017795'
apa: 'Reid, T. D., Carenzo, M., Pellicciotti, F., & Brock, B. W. (2012). Including
debris cover effects in a distributed model of glacier ablation. Journal of
Geophysical Research: Atmospheres. American Geophysical Union. https://doi.org/10.1029/2012jd017795'
chicago: 'Reid, T. D., M. Carenzo, Francesca Pellicciotti, and B. W. Brock. “Including
Debris Cover Effects in a Distributed Model of Glacier Ablation.” Journal of
Geophysical Research: Atmospheres. American Geophysical Union, 2012. https://doi.org/10.1029/2012jd017795.'
ieee: 'T. D. Reid, M. Carenzo, F. Pellicciotti, and B. W. Brock, “Including debris
cover effects in a distributed model of glacier ablation,” Journal of Geophysical
Research: Atmospheres, vol. 117, no. D18. American Geophysical Union, 2012.'
ista: 'Reid TD, Carenzo M, Pellicciotti F, Brock BW. 2012. Including debris cover
effects in a distributed model of glacier ablation. Journal of Geophysical Research:
Atmospheres. 117(D18), D18105.'
mla: 'Reid, T. D., et al. “Including Debris Cover Effects in a Distributed Model
of Glacier Ablation.” Journal of Geophysical Research: Atmospheres, vol.
117, no. D18, D18105, American Geophysical Union, 2012, doi:10.1029/2012jd017795.'
short: 'T.D. Reid, M. Carenzo, F. Pellicciotti, B.W. Brock, Journal of Geophysical
Research: Atmospheres 117 (2012).'
date_created: 2023-02-20T08:17:57Z
date_published: 2012-09-27T00:00:00Z
date_updated: 2023-02-20T10:57:31Z
day: '27'
doi: 10.1029/2012jd017795
extern: '1'
fulldoi: https://doi.org/10.1029/2012jd017795
intvolume: ' 117'
issue: D18
keyword:
- Paleontology
- Space and Planetary Science
- Earth and Planetary Sciences (miscellaneous)
- Atmospheric Science
- Earth-Surface Processes
- Geochemistry and Petrology
- Soil Science
- Water Science and Technology
- Ecology
- Aquatic Science
- Forestry
- Oceanography
- Geophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1029/2012JD017795
month: '09'
oa: 1
oa_version: Published Version
publication: 'Journal of Geophysical Research: Atmospheres'
publication_identifier:
issn:
- 0148-0227
publication_status: published
publisher: American Geophysical Union
quality_controlled: '1'
scopus_import: '1'
status: public
title: Including debris cover effects in a distributed model of glacier ablation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 117
year: '2012'
...
---
_id: '13075'
abstract:
- lang: eng
text: Little is known about the stability of trophic relationships in complex natural
communities over evolutionary timescales. Here, we use sequence data from 18 nuclear
loci to reconstruct and compare the intraspecific histories of major Pleistocene
refugial populations in the Middle East, the Balkans and Iberia in a guild of
four Chalcid parasitoids (Cecidostiba fungosa, C. semifascia, Hobbya stenonota
and Mesopolobus amaenus) all attacking Cynipid oak galls. We develop a likelihood
method to numerically estimate models of divergence between three populations
from multilocus data. We investigate the power of this framework on simulated
data, and - using triplet alignments of intronic loci - quantify the support for
all possible divergence relationships between refugial populations in the four
parasitoids. Although an East to West order of population divergence has highest
support in all but one species, we cannot rule out alternative population tree
topologies. Comparing the estimated times of population splits between species,
we find that one species, M. amaenus, has a significantly older history than the
rest of the guild and must have arrived in central Europe at least one glacial
cycle prior to other guild members. This suggests that although all four species
may share a common origin in the East, they expanded westwards into Europe at
different times.
article_processing_charge: No
author:
- first_name: Konrad
full_name: Lohse, Konrad
last_name: Lohse
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Graham
full_name: Stone, Graham
last_name: Stone
- first_name: George
full_name: Melika, George
last_name: Melika
citation:
ama: 'Lohse K, Barton NH, Stone G, Melika G. Data from: A likelihood-based comparison
of population histories in a parasitoid guild. 2012. doi:10.5061/DRYAD.0G0FS'
apa: 'Lohse, K., Barton, N. H., Stone, G., & Melika, G. (2012). Data from: A
likelihood-based comparison of population histories in a parasitoid guild. Dryad.
https://doi.org/10.5061/DRYAD.0G0FS'
chicago: 'Lohse, Konrad, Nicholas H Barton, Graham Stone, and George Melika. “Data
from: A Likelihood-Based Comparison of Population Histories in a Parasitoid Guild.”
Dryad, 2012. https://doi.org/10.5061/DRYAD.0G0FS.'
ieee: 'K. Lohse, N. H. Barton, G. Stone, and G. Melika, “Data from: A likelihood-based
comparison of population histories in a parasitoid guild.” Dryad, 2012.'
ista: 'Lohse K, Barton NH, Stone G, Melika G. 2012. Data from: A likelihood-based
comparison of population histories in a parasitoid guild, Dryad, 10.5061/DRYAD.0G0FS.'
mla: 'Lohse, Konrad, et al. Data from: A Likelihood-Based Comparison of Population
Histories in a Parasitoid Guild. Dryad, 2012, doi:10.5061/DRYAD.0G0FS.'
short: K. Lohse, N.H. Barton, G. Stone, G. Melika, (2012).
date_created: 2023-05-23T17:01:02Z
date_published: 2012-06-08T00:00:00Z
date_updated: 2025-09-30T08:04:02Z
day: '08'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.5061/DRYAD.0G0FS
fulldoi: https://doi.org/10.5061/DRYAD.0G0FS
license: https://creativecommons.org/publicdomain/zero/1.0/
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.0g0fs
month: '06'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '2968'
relation: used_in_publication
status: public
status: public
title: 'Data from: A likelihood-based comparison of population histories in a parasitoid
guild'
tmp:
image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
name: Creative Commons Public Domain Dedication (CC0 1.0)
short: CC0 (1.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2012'
...
---
_id: '2101'
abstract:
- lang: eng
text: 'Articulated deformable characters are widespread in computer animation. Unfortunately,
we lack methods for their automatic fabrication using modern additive manufacturing
(AM) technologies. We propose a method that takes a skinned mesh as input, then
estimates a fabricatable single-material model that approximates the 3D kinematics
of the corresponding virtual articulated character in a piecewise linear manner.
We first extract a set of potential joint locations. From this set, together with
optional, user-specified range constraints, we then estimate mechanical friction
joints that satisfy inter-joint non-penetration and other fabrication constraints.
To avoid brittle joint designs, we place joint centers on an approximate medial
axis representation of the input geometry, and maximize each joint''s minimal
cross-sectional area. We provide several demonstrations, manufactured as single,
assembled pieces using 3D printers. '
acknowledgement: This work was partially supported by NSF grant IIS-1116619. Doug
James acknowledges support from Pixar and a fellowship from the John Simon Guggenheim
Memorial Foundation
author:
- first_name: Moritz
full_name: Bac̈her, Moritz
last_name: Bac̈Her
- first_name: Bernd
full_name: Bernd Bickel
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
- first_name: Doug
full_name: James, Doug L
last_name: James
- first_name: Hanspeter
full_name: Pfister, Hanspeter
last_name: Pfister
citation:
ama: Bac̈Her M, Bickel B, James D, Pfister H. Fabricating articulated characters
from skinned meshes. ACM Transactions on Graphics. 2012;31(4). doi:10.1145/2185520.2185543
apa: Bac̈Her, M., Bickel, B., James, D., & Pfister, H. (2012). Fabricating articulated
characters from skinned meshes. ACM Transactions on Graphics. ACM. https://doi.org/10.1145/2185520.2185543
chicago: Bac̈Her, Moritz, Bernd Bickel, Doug James, and Hanspeter Pfister. “Fabricating
Articulated Characters from Skinned Meshes.” ACM Transactions on Graphics.
ACM, 2012. https://doi.org/10.1145/2185520.2185543.
ieee: M. Bac̈Her, B. Bickel, D. James, and H. Pfister, “Fabricating articulated
characters from skinned meshes,” ACM Transactions on Graphics, vol. 31,
no. 4. ACM, 2012.
ista: Bac̈Her M, Bickel B, James D, Pfister H. 2012. Fabricating articulated characters
from skinned meshes. ACM Transactions on Graphics. 31(4).
mla: Bac̈Her, Moritz, et al. “Fabricating Articulated Characters from Skinned Meshes.”
ACM Transactions on Graphics, vol. 31, no. 4, ACM, 2012, doi:10.1145/2185520.2185543.
short: M. Bac̈Her, B. Bickel, D. James, H. Pfister, ACM Transactions on Graphics
31 (2012).
date_created: 2018-12-11T11:55:43Z
date_published: 2012-01-01T00:00:00Z
date_updated: 2021-01-12T06:55:19Z
day: '01'
doi: 10.1145/2185520.2185543
extern: 1
fulldoi: https://doi.org/10.1145/2185520.2185543
intvolume: ' 31'
issue: '4'
month: '01'
publication: ACM Transactions on Graphics
publication_status: published
publisher: ACM
publist_id: '4933'
quality_controlled: 0
status: public
title: Fabricating articulated characters from skinned meshes
type: journal_article
volume: 31
year: '2012'
...
---
_id: '2102'
abstract:
- lang: eng
text: 'We propose a complete process for designing, simulating, and fabricating
synthetic skin for an animatronics character that mimics the face of a given subject
and its expressions. The process starts with measuring the elastic properties
of a material used to manufacture synthetic soft tissue. Given these measurements
we use physicsbased simulation to predict the behavior of a face when it is driven
by the underlying robotic actuation. Next, we capture 3D facial expressions for
a given target subject. As the key component of our process, we present a novel
optimization scheme that determines the shape of the synthetic skin as well as
the actuation parameters that provide the best match to the target expressions.
We demonstrate this computational skin design by physically cloning a real human
face onto an animatronics figure. '
acknowledgement: This work was supported in part by the NCCR Co-Me of the Swiss NSF
author:
- first_name: Bernd
full_name: Bernd Bickel
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
- first_name: Peter
full_name: Kaufmann, Peter
last_name: Kaufmann
- first_name: Mélina
full_name: Skouras, Mélina
last_name: Skouras
- first_name: Bernhard
full_name: Thomaszewski, Bernhard
last_name: Thomaszewski
- first_name: Derek
full_name: Bradley, Derek J
last_name: Bradley
- first_name: Thabo
full_name: Beeler, Thabo
last_name: Beeler
- first_name: Philip
full_name: Jackson, Philip V
last_name: Jackson
- first_name: Steve
full_name: Marschner, Steve
last_name: Marschner
- first_name: Wojciech
full_name: Matusik, Wojciech
last_name: Matusik
- first_name: Markus
full_name: Groß, Markus S
last_name: Groß
citation:
ama: Bickel B, Kaufmann P, Skouras M, et al. Physical face cloning. ACM Transactions
on Graphics. 2012;31(4). doi:10.1145/2185520.2185614
apa: Bickel, B., Kaufmann, P., Skouras, M., Thomaszewski, B., Bradley, D., Beeler,
T., … Groß, M. (2012). Physical face cloning. ACM Transactions on Graphics.
ACM. https://doi.org/10.1145/2185520.2185614
chicago: Bickel, Bernd, Peter Kaufmann, Mélina Skouras, Bernhard Thomaszewski, Derek
Bradley, Thabo Beeler, Philip Jackson, Steve Marschner, Wojciech Matusik, and
Markus Groß. “Physical Face Cloning.” ACM Transactions on Graphics. ACM,
2012. https://doi.org/10.1145/2185520.2185614.
ieee: B. Bickel et al., “Physical face cloning,” ACM Transactions on Graphics,
vol. 31, no. 4. ACM, 2012.
ista: Bickel B, Kaufmann P, Skouras M, Thomaszewski B, Bradley D, Beeler T, Jackson
P, Marschner S, Matusik W, Groß M. 2012. Physical face cloning. ACM Transactions
on Graphics. 31(4).
mla: Bickel, Bernd, et al. “Physical Face Cloning.” ACM Transactions on Graphics,
vol. 31, no. 4, ACM, 2012, doi:10.1145/2185520.2185614.
short: B. Bickel, P. Kaufmann, M. Skouras, B. Thomaszewski, D. Bradley, T. Beeler,
P. Jackson, S. Marschner, W. Matusik, M. Groß, ACM Transactions on Graphics 31
(2012).
date_created: 2018-12-11T11:55:43Z
date_published: 2012-07-04T00:00:00Z
date_updated: 2021-01-12T06:55:19Z
day: '04'
doi: 10.1145/2185520.2185614
extern: 1
fulldoi: https://doi.org/10.1145/2185520.2185614
intvolume: ' 31'
issue: '4'
month: '07'
publication: ACM Transactions on Graphics
publication_status: published
publisher: ACM
publist_id: '4931'
quality_controlled: 0
status: public
title: Physical face cloning
type: journal_article
volume: 31
year: '2012'
...
---
_id: '2103'
abstract:
- lang: eng
text: Although facial hair plays an important role in individual expression, facial-hair
reconstruction is not addressed by current facecapture systems. Our research addresses
this limitation with an algorithm that treats hair and skin surface capture together
in a coupled fashion so that a high-quality representation of hair fibers as well
as the underlying skin surface can be reconstructed. We propose a passive, camera-based
system that is robust against arbitrary motion since all data is acquired within
the time period of a single exposure. Our reconstruction algorithm detects and
traces hairs in the captured images and reconstructs them in 3D using a multiview
stereo approach. Our coupled skin-reconstruction algorithm uses information about
the detected hairs to deliver a skin surface that lies underneath all hairs irrespective
of occlusions. In dense regions like eyebrows, we employ a hair-synthesis method
to create hair fibers that plausibly match the image data. We demonstrate our
scanning system on a number of individuals and show that it can successfully reconstruct
a variety of facial-hair styles together with the underlying skin surface.
author:
- first_name: Thabo
full_name: Beeler, Thabo
last_name: Beeler
- first_name: Bernd
full_name: Bernd Bickel
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
- first_name: Gioacchino
full_name: Noris, Gioacchino
last_name: Noris
- first_name: Paul
full_name: Beardsley, Paul A
last_name: Beardsley
- first_name: Steve
full_name: Marschner, Steve
last_name: Marschner
- first_name: Robert
full_name: Sumner, Robert W
last_name: Sumner
- first_name: Markus
full_name: Groß, Markus S
last_name: Groß
citation:
ama: Beeler T, Bickel B, Noris G, et al. Coupled 3D reconstruction of sparse facial
hair and skin. ACM Transactions on Graphics. 2012;31(4). doi:10.1145/2185520.2185613
apa: Beeler, T., Bickel, B., Noris, G., Beardsley, P., Marschner, S., Sumner, R.,
& Groß, M. (2012). Coupled 3D reconstruction of sparse facial hair and skin.
ACM Transactions on Graphics. ACM. https://doi.org/10.1145/2185520.2185613
chicago: Beeler, Thabo, Bernd Bickel, Gioacchino Noris, Paul Beardsley, Steve Marschner,
Robert Sumner, and Markus Groß. “Coupled 3D Reconstruction of Sparse Facial Hair
and Skin.” ACM Transactions on Graphics. ACM, 2012. https://doi.org/10.1145/2185520.2185613.
ieee: T. Beeler et al., “Coupled 3D reconstruction of sparse facial hair
and skin,” ACM Transactions on Graphics, vol. 31, no. 4. ACM, 2012.
ista: Beeler T, Bickel B, Noris G, Beardsley P, Marschner S, Sumner R, Groß M. 2012.
Coupled 3D reconstruction of sparse facial hair and skin. ACM Transactions on
Graphics. 31(4).
mla: Beeler, Thabo, et al. “Coupled 3D Reconstruction of Sparse Facial Hair and
Skin.” ACM Transactions on Graphics, vol. 31, no. 4, ACM, 2012, doi:10.1145/2185520.2185613.
short: T. Beeler, B. Bickel, G. Noris, P. Beardsley, S. Marschner, R. Sumner, M.
Groß, ACM Transactions on Graphics 31 (2012).
date_created: 2018-12-11T11:55:44Z
date_published: 2012-01-01T00:00:00Z
date_updated: 2021-01-12T06:55:20Z
day: '01'
doi: 10.1145/2185520.2185613
extern: 1
fulldoi: https://doi.org/10.1145/2185520.2185613
intvolume: ' 31'
issue: '4'
month: '01'
publication: ACM Transactions on Graphics
publication_status: published
publisher: ACM
publist_id: '4932'
quality_controlled: 0
status: public
title: Coupled 3D reconstruction of sparse facial hair and skin
type: journal_article
volume: 31
year: '2012'
...
---
_id: '2104'
abstract:
- lang: eng
text: 'In recent years, various methods have been introduced to exploit pre-recorded
data to improve the performance and/or realism of dynamic deformations, but their
differences and similarities have not been adequately analyzed or discussed. So
far, the proposed methods have been explored mainly in the research context. They
have not been adopted by the computer graphics industry. This course bridges the
gap between research labs and industry to present a unifying theory and understanding
of data-driven methods for dynamic deformations that may inspire development of
novel solutions. It focuses on application of data-driven methods to three areas
of computer animation: dynamic deformation of faces, soft volumetric tissue, and
cloth. And it describes how to approach these challenges in a data-driven manner,
classifies the various methods, and demonstrates how data-driven methods can work
in other settings. '
author:
- first_name: Miguel
full_name: Otaduy, Miguel A
last_name: Otaduy
- first_name: Bernd
full_name: Bernd Bickel
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
- first_name: Derek
full_name: Bradley, Derek J
last_name: Bradley
- first_name: Huamin
full_name: Wang, Huamin
last_name: Wang
citation:
ama: 'Otaduy M, Bickel B, Bradley D, Wang H. Data-driven simulation methods in computer
graphics: Cloth, tissue and faces. In: ACM; 2012. doi:10.1145/2343483.2343495'
apa: 'Otaduy, M., Bickel, B., Bradley, D., & Wang, H. (2012). Data-driven simulation
methods in computer graphics: Cloth, tissue and faces. Presented at the SIGGRAPH:
Special Interest Group on Computer Graphics and Interactive Techniques, ACM. https://doi.org/10.1145/2343483.2343495'
chicago: 'Otaduy, Miguel, Bernd Bickel, Derek Bradley, and Huamin Wang. “Data-Driven
Simulation Methods in Computer Graphics: Cloth, Tissue and Faces.” ACM, 2012.
https://doi.org/10.1145/2343483.2343495.'
ieee: 'M. Otaduy, B. Bickel, D. Bradley, and H. Wang, “Data-driven simulation methods
in computer graphics: Cloth, tissue and faces,” presented at the SIGGRAPH: Special
Interest Group on Computer Graphics and Interactive Techniques, 2012.'
ista: 'Otaduy M, Bickel B, Bradley D, Wang H. 2012. Data-driven simulation methods
in computer graphics: Cloth, tissue and faces. SIGGRAPH: Special Interest Group
on Computer Graphics and Interactive Techniques.'
mla: 'Otaduy, Miguel, et al. Data-Driven Simulation Methods in Computer Graphics:
Cloth, Tissue and Faces. ACM, 2012, doi:10.1145/2343483.2343495.'
short: M. Otaduy, B. Bickel, D. Bradley, H. Wang, in:, ACM, 2012.
conference:
name: 'SIGGRAPH: Special Interest Group on Computer Graphics and Interactive Techniques'
date_created: 2018-12-11T11:55:44Z
date_published: 2012-01-01T00:00:00Z
date_updated: 2021-01-12T06:55:20Z
day: '01'
doi: 10.1145/2343483.2343495
extern: 1
fulldoi: https://doi.org/10.1145/2343483.2343495
month: '01'
publication_status: published
publisher: ACM
publist_id: '4930'
quality_controlled: 0
status: public
title: 'Data-driven simulation methods in computer graphics: Cloth, tissue and faces'
type: conference
year: '2012'
...
---
_id: '2105'
acknowledgement: Mélina Skouras was partially supported by the NCCR Co-Me of the Swiss
National Science Foundation.
author:
- first_name: Mélina
full_name: Skouras, Mélina
last_name: Skouras
- first_name: Bernhard
full_name: Thomaszewski, Bernhard
last_name: Thomaszewski
- first_name: Bernd
full_name: Bernd Bickel
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
- first_name: Markus
full_name: Groß, Markus S
last_name: Groß
citation:
ama: 'Skouras M, Thomaszewski B, Bickel B, Groß M. Computational design of rubber
balloons. In: Vol 31. Wiley-Blackwell; 2012:835-844. doi:10.1111/j.1467-8659.2012.03064.x'
apa: 'Skouras, M., Thomaszewski, B., Bickel, B., & Groß, M. (2012). Computational
design of rubber balloons (Vol. 31, pp. 835–844). Presented at the EUROGRAPHICS:
European Association for Computer Graphics, Wiley-Blackwell. https://doi.org/10.1111/j.1467-8659.2012.03064.x'
chicago: Skouras, Mélina, Bernhard Thomaszewski, Bernd Bickel, and Markus Groß.
“Computational Design of Rubber Balloons,” 31:835–44. Wiley-Blackwell, 2012. https://doi.org/10.1111/j.1467-8659.2012.03064.x.
ieee: 'M. Skouras, B. Thomaszewski, B. Bickel, and M. Groß, “Computational design
of rubber balloons,” presented at the EUROGRAPHICS: European Association for Computer
Graphics, 2012, vol. 31, no. 2, pp. 835–844.'
ista: 'Skouras M, Thomaszewski B, Bickel B, Groß M. 2012. Computational design of
rubber balloons. EUROGRAPHICS: European Association for Computer Graphics vol.
31, 835–844.'
mla: Skouras, Mélina, et al. Computational Design of Rubber Balloons. Vol.
31, no. 2, Wiley-Blackwell, 2012, pp. 835–44, doi:10.1111/j.1467-8659.2012.03064.x.
short: M. Skouras, B. Thomaszewski, B. Bickel, M. Groß, in:, Wiley-Blackwell, 2012,
pp. 835–844.
conference:
name: 'EUROGRAPHICS: European Association for Computer Graphics'
date_created: 2018-12-11T11:55:45Z
date_published: 2012-05-01T00:00:00Z
date_updated: 2021-01-12T06:55:20Z
day: '01'
doi: 10.1111/j.1467-8659.2012.03064.x
extern: 1
fulldoi: https://doi.org/10.1111/j.1467-8659.2012.03064.x
intvolume: ' 31'
issue: '2'
month: '05'
page: 835 - 844
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4928'
quality_controlled: 0
status: public
title: Computational design of rubber balloons
type: conference
volume: 31
year: '2012'
...
---
_id: '2106'
abstract:
- lang: eng
text: Progress in cloth simulation for computer animation and apparel design has
led to a multitude of deformation models, each with its own way of relating geometry,
deformation, and forces. As simulators improve, differences between these models
become more important, but it is difficult to choose a model and a set of parameters
to match a given real material simply by looking at simulation results. This paper
provides measurement and fitting methods that allow nonlinear models to be fit
to the observed deformation of a particular cloth sample. Unlike standard textile
testing, our system measures complex 3D deformations of a sheet of cloth, not
just one-dimensional force-displacement curves, so it works under a wider range
of deformation conditions. The fitted models are then evaluated by comparison
to measured deformations with motions very different from those used for fitting.
acknowledgement: This work was funded in part by the Spanish Ministry of Science and
Innovation, project TIN2009-07942, and by the European Research Council, project
ERC-2011-StG-280135 Animetrics.
author:
- first_name: Eder
full_name: Miguel, Eder
last_name: Miguel
- first_name: Derek
full_name: Bradley, Derek J
last_name: Bradley
- first_name: Bernhard
full_name: Thomaszewski, Bernhard
last_name: Thomaszewski
- first_name: Bernd
full_name: Bernd Bickel
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
- first_name: Wojciech
full_name: Matusik, Wojciech
last_name: Matusik
- first_name: Miguel
full_name: Otaduy, Miguel A
last_name: Otaduy
- first_name: Steve
full_name: Marschner, Steve
last_name: Marschner
citation:
ama: 'Miguel E, Bradley D, Thomaszewski B, et al. Data-driven estimation of cloth
simulation models. In: Vol 31. Wiley-Blackwell; 2012:519-528. doi:10.1111/j.1467-8659.2012.03031.x'
apa: Miguel, E., Bradley, D., Thomaszewski, B., Bickel, B., Matusik, W., Otaduy,
M., & Marschner, S. (2012). Data-driven estimation of cloth simulation models
(Vol. 31, pp. 519–528). Presented at the Computer Graphics Forum, Wiley-Blackwell.
https://doi.org/10.1111/j.1467-8659.2012.03031.x
chicago: Miguel, Eder, Derek Bradley, Bernhard Thomaszewski, Bernd Bickel, Wojciech
Matusik, Miguel Otaduy, and Steve Marschner. “Data-Driven Estimation of Cloth
Simulation Models,” 31:519–28. Wiley-Blackwell, 2012. https://doi.org/10.1111/j.1467-8659.2012.03031.x.
ieee: E. Miguel et al., “Data-driven estimation of cloth simulation models,”
presented at the Computer Graphics Forum, 2012, vol. 31, no. 2, pp. 519–528.
ista: Miguel E, Bradley D, Thomaszewski B, Bickel B, Matusik W, Otaduy M, Marschner
S. 2012. Data-driven estimation of cloth simulation models. Computer Graphics
Forum vol. 31, 519–528.
mla: Miguel, Eder, et al. Data-Driven Estimation of Cloth Simulation Models.
Vol. 31, no. 2, Wiley-Blackwell, 2012, pp. 519–28, doi:10.1111/j.1467-8659.2012.03031.x.
short: E. Miguel, D. Bradley, B. Thomaszewski, B. Bickel, W. Matusik, M. Otaduy,
S. Marschner, in:, Wiley-Blackwell, 2012, pp. 519–528.
conference:
name: Computer Graphics Forum
date_created: 2018-12-11T11:55:45Z
date_published: 2012-05-01T00:00:00Z
date_updated: 2021-01-12T06:55:21Z
day: '01'
doi: 10.1111/j.1467-8659.2012.03031.x
extern: 1
fulldoi: https://doi.org/10.1111/j.1467-8659.2012.03031.x
intvolume: ' 31'
issue: '2'
month: '05'
page: 519 - 528
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4929'
quality_controlled: 0
status: public
title: Data-driven estimation of cloth simulation models
type: conference
volume: 31
year: '2012'
...
---
OA_type: closed access
_id: '21104'
abstract:
- lang: eng
text: Crystal structures of the hexanucleotide d(CACGCG)·d(CGCGTG) were determined
in two crystal lattices when different concentrations of the counterion Mn2+ were
used in crystallization. The availability of Mn2+ during the crystallization process
appears to play an important role in inducing different crystal packings that
lead to crystals belonging to the two space groups P21 and P65. Analysis of the
molecular interactions of Mn2+ with the Z-form duplexes shows direct coordination
to the purine residues G and A.
article_processing_charge: No
article_type: original
author:
- first_name: Pradeep K
full_name: Mandal, Pradeep K
id: 6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
last_name: Mandal
orcid: 0000-0001-5996-956X
- first_name: S.
full_name: Venkadesh, S.
last_name: Venkadesh
- first_name: N.
full_name: Gautham, N.
last_name: Gautham
citation:
ama: Mandal PK, Venkadesh S, Gautham N. Interactions of Mn2+ with a non-self-complementary
Z-type DNA duplex. Acta Crystallographica Section F Structural Biology Communications.
2012;68(12):1420-1426. doi:10.1107/s1744309112041759
apa: Mandal, P. K., Venkadesh, S., & Gautham, N. (2012). Interactions of Mn2+
with a non-self-complementary Z-type DNA duplex. Acta Crystallographica Section
F Structural Biology Communications. International Union of Crystallography.
https://doi.org/10.1107/s1744309112041759
chicago: Mandal, Pradeep K, S. Venkadesh, and N. Gautham. “Interactions of Mn2+
with a Non-Self-Complementary Z-Type DNA Duplex.” Acta Crystallographica Section
F Structural Biology Communications. International Union of Crystallography,
2012. https://doi.org/10.1107/s1744309112041759.
ieee: P. K. Mandal, S. Venkadesh, and N. Gautham, “Interactions of Mn2+ with a non-self-complementary
Z-type DNA duplex,” Acta Crystallographica Section F Structural Biology Communications,
vol. 68, no. 12. International Union of Crystallography, pp. 1420–1426, 2012.
ista: Mandal PK, Venkadesh S, Gautham N. 2012. Interactions of Mn2+ with a non-self-complementary
Z-type DNA duplex. Acta Crystallographica Section F Structural Biology Communications.
68(12), 1420–1426.
mla: Mandal, Pradeep K., et al. “Interactions of Mn2+ with a Non-Self-Complementary
Z-Type DNA Duplex.” Acta Crystallographica Section F Structural Biology Communications,
vol. 68, no. 12, International Union of Crystallography, 2012, pp. 1420–26, doi:10.1107/s1744309112041759.
short: P.K. Mandal, S. Venkadesh, N. Gautham, Acta Crystallographica Section F Structural
Biology Communications 68 (2012) 1420–1426.
date_created: 2026-01-29T21:59:50Z
date_published: 2012-12-01T00:00:00Z
date_updated: 2026-02-23T09:07:01Z
day: '01'
doi: 10.1107/s1744309112041759
extern: '1'
fulldoi: https://doi.org/10.1107/s1744309112041759
has_accepted_license: '1'
intvolume: ' 68'
issue: '12'
language:
- iso: eng
month: '12'
oa_version: None
page: 1420-1426
publication: Acta Crystallographica Section F Structural Biology Communications
publication_identifier:
issn:
- 1744-3091
publication_status: published
publisher: International Union of Crystallography
quality_controlled: '1'
status: public
title: Interactions of Mn2+ with a non-self-complementary Z-type DNA duplex
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 68
year: '2012'
...
---
OA_type: closed access
_id: '21105'
abstract:
- lang: eng
text: The hexamer duplex d(CACGCG).d(CGCGTG) produces unusual hexagonal ring shaped
crystals when crystallized in the presence of cobalt hexammine chloride. Observation
of the growth of these crystals over a period of about 6 days indicated that this
morphology resulted from radial dissolution of the crystal from the center of
the well-formed hexagonal plates. X-ray diffraction studies were carried out for
crystals of four stages in the ring crystal morphology. The structure of the DNA
in all four crystals was the Z type DNA double helix. The packing mode of the
Z DNA duplex in all four crystal structures was that of the ‘spermine’ form. The
crystal morphology changes from hexagonal plates to hexagonal rings without any
apparent change in the molecular structure of the oligonucleotide or helical packing
of the duplexes.
article_processing_charge: No
article_type: original
author:
- first_name: Pradeep K
full_name: Mandal, Pradeep K
id: 6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
last_name: Mandal
orcid: 0000-0001-5996-956X
- first_name: Arun Richard
full_name: Chandrasekaran, Arun Richard
last_name: Chandrasekaran
- first_name: Bharath Raj
full_name: Madhanagopal, Bharath Raj
last_name: Madhanagopal
- first_name: Sarkarai
full_name: Venkadesh, Sarkarai
last_name: Venkadesh
- first_name: Namasivayam
full_name: Gautham, Namasivayam
last_name: Gautham
citation:
ama: 'Mandal PK, Chandrasekaran AR, Madhanagopal BR, Venkadesh S, Gautham N. Ring
crystals of oligonucleotides: Growth stages and X-ray diffraction studies. Journal
of Crystal Growth. 2012;354(1):20-26. doi:10.1016/j.jcrysgro.2012.05.029'
apa: 'Mandal, P. K., Chandrasekaran, A. R., Madhanagopal, B. R., Venkadesh, S.,
& Gautham, N. (2012). Ring crystals of oligonucleotides: Growth stages and
X-ray diffraction studies. Journal of Crystal Growth. Elsevier. https://doi.org/10.1016/j.jcrysgro.2012.05.029'
chicago: 'Mandal, Pradeep K, Arun Richard Chandrasekaran, Bharath Raj Madhanagopal,
Sarkarai Venkadesh, and Namasivayam Gautham. “Ring Crystals of Oligonucleotides:
Growth Stages and X-Ray Diffraction Studies.” Journal of Crystal Growth.
Elsevier, 2012. https://doi.org/10.1016/j.jcrysgro.2012.05.029.'
ieee: 'P. K. Mandal, A. R. Chandrasekaran, B. R. Madhanagopal, S. Venkadesh, and
N. Gautham, “Ring crystals of oligonucleotides: Growth stages and X-ray diffraction
studies,” Journal of Crystal Growth, vol. 354, no. 1. Elsevier, pp. 20–26,
2012.'
ista: 'Mandal PK, Chandrasekaran AR, Madhanagopal BR, Venkadesh S, Gautham N. 2012.
Ring crystals of oligonucleotides: Growth stages and X-ray diffraction studies.
Journal of Crystal Growth. 354(1), 20–26.'
mla: 'Mandal, Pradeep K., et al. “Ring Crystals of Oligonucleotides: Growth Stages
and X-Ray Diffraction Studies.” Journal of Crystal Growth, vol. 354, no.
1, Elsevier, 2012, pp. 20–26, doi:10.1016/j.jcrysgro.2012.05.029.'
short: P.K. Mandal, A.R. Chandrasekaran, B.R. Madhanagopal, S. Venkadesh, N. Gautham,
Journal of Crystal Growth 354 (2012) 20–26.
date_created: 2026-01-29T22:02:59Z
date_published: 2012-09-01T00:00:00Z
date_updated: 2026-02-20T09:15:22Z
day: '01'
doi: 10.1016/j.jcrysgro.2012.05.029
extern: '1'
fulldoi: https://doi.org/10.1016/j.jcrysgro.2012.05.029
has_accepted_license: '1'
intvolume: ' 354'
issue: '1'
language:
- iso: eng
month: '09'
oa_version: None
page: 20-26
publication: Journal of Crystal Growth
publication_identifier:
issn:
- 0022-0248
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Ring crystals of oligonucleotides: Growth stages and X-ray diffraction studies'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 354
year: '2012'
...
---
OA_type: closed access
_id: '21106'
abstract:
- lang: eng
text: The crystal structure of the tetradecanucleotide sequence d(CCCCGGTACCGGGG)2
has been determined at 2.5 Å resolution in the tetragonal space group P41. This
sequence was designed with the expectation of a four-way junction. However, the
sequence crystallized as an A-DNA duplex and represents more than one full turn
of the A-helix. The crystallographic asymmetric unit consists of one tetradecanucleotide
duplex. The structural parameters of the A-type DNA duplex structure and the crystal-packing
arrangement are described. One Mn2+ ion was identified with direct coordination
to the N7 position of G13 and a water molecule at the major-groove side of the
C2·G13 base pair.
article_processing_charge: No
article_type: original
author:
- first_name: Pradeep K
full_name: Mandal, Pradeep K
id: 6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
last_name: Mandal
orcid: 0000-0001-5996-956X
- first_name: Sarkarai
full_name: Venkadesh, Sarkarai
last_name: Venkadesh
- first_name: Namasivayam
full_name: Gautham, Namasivayam
last_name: Gautham
citation:
ama: Mandal PK, Venkadesh S, Gautham N. Structure of the tetradecanucleotide d(CCCCGGTACCGGGG)2
as an A-DNA duplex. Acta Crystallographica Section F Structural Biology Communications.
2012;68(4):393-399. doi:10.1107/s174430911200869x
apa: Mandal, P. K., Venkadesh, S., & Gautham, N. (2012). Structure of the tetradecanucleotide
d(CCCCGGTACCGGGG)2 as an A-DNA duplex. Acta Crystallographica Section F Structural
Biology Communications. International Union of Crystallography. https://doi.org/10.1107/s174430911200869x
chicago: Mandal, Pradeep K, Sarkarai Venkadesh, and Namasivayam Gautham. “Structure
of the Tetradecanucleotide d(CCCCGGTACCGGGG)2 as an A-DNA Duplex.” Acta Crystallographica
Section F Structural Biology Communications. International Union of Crystallography,
2012. https://doi.org/10.1107/s174430911200869x.
ieee: P. K. Mandal, S. Venkadesh, and N. Gautham, “Structure of the tetradecanucleotide
d(CCCCGGTACCGGGG)2 as an A-DNA duplex,” Acta Crystallographica Section F Structural
Biology Communications, vol. 68, no. 4. International Union of Crystallography,
pp. 393–399, 2012.
ista: Mandal PK, Venkadesh S, Gautham N. 2012. Structure of the tetradecanucleotide
d(CCCCGGTACCGGGG)2 as an A-DNA duplex. Acta Crystallographica Section F Structural
Biology Communications. 68(4), 393–399.
mla: Mandal, Pradeep K., et al. “Structure of the Tetradecanucleotide d(CCCCGGTACCGGGG)2
as an A-DNA Duplex.” Acta Crystallographica Section F Structural Biology Communications,
vol. 68, no. 4, International Union of Crystallography, 2012, pp. 393–99, doi:10.1107/s174430911200869x.
short: P.K. Mandal, S. Venkadesh, N. Gautham, Acta Crystallographica Section F Structural
Biology Communications 68 (2012) 393–399.
date_created: 2026-01-29T22:04:31Z
date_published: 2012-04-01T00:00:00Z
date_updated: 2026-02-23T08:58:07Z
day: '01'
doi: 10.1107/s174430911200869x
extern: '1'
fulldoi: https://doi.org/10.1107/s174430911200869x
has_accepted_license: '1'
intvolume: ' 68'
issue: '4'
language:
- iso: eng
month: '04'
oa_version: None
page: 393-399
publication: Acta Crystallographica Section F Structural Biology Communications
publication_identifier:
issn:
- 1744-3091
publication_status: published
publisher: International Union of Crystallography
quality_controlled: '1'
status: public
title: Structure of the tetradecanucleotide d(CCCCGGTACCGGGG)2 as an A-DNA duplex
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 68
year: '2012'
...
---
OA_place: publisher
OA_type: free access
_id: '21111'
abstract:
- lang: eng
text: Inhibiting PLA2 activity should, in theory, be an effective approach to control
the inflammation. Several naturally occurring polyphenolic compounds have been
reported as inhibitors of PLA2. Among the naturally occurring polyphenols, catechol
(1,2-dihydroxybenzene) possesses anti-inflammatory activity. Catechol can inhibit
cyclooxygenase and lipo-oxygenase. By means of enzyme kinetic study, it was revealed
that catechol can inhibit PLA2 also. Crystal structure showed that catechol binds
to PLA2 at the opening of the active site cleft. This might stop the entry of
substrate into the active site. Hence, catechol can be used as a lead compound
for the development of novel anti-inflammatory drugs with PLA2 as the target.
article_processing_charge: No
article_type: original
author:
- first_name: Kalarickal V.
full_name: Dileep, Kalarickal V.
last_name: Dileep
- first_name: Ignatius
full_name: Tintu, Ignatius
last_name: Tintu
- first_name: Pradeep K
full_name: Mandal, Pradeep K
id: 6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
last_name: Mandal
orcid: 0000-0001-5996-956X
- first_name: Ponnuraj
full_name: Karthe, Ponnuraj
last_name: Karthe
- first_name: Madathilkovilakathu
full_name: Haridas, Madathilkovilakathu
last_name: Haridas
- first_name: Chittalakkottu
full_name: Sadasivan, Chittalakkottu
last_name: Sadasivan
citation:
ama: Dileep KV, Tintu I, Mandal PK, Karthe P, Haridas M, Sadasivan C. Binding to
PLA2 may contribute to the anti‐inflammatory activity of catechol. Chemical
Biology & Drug Design. 2012;79(1):143-147. doi:10.1111/j.1747-0285.2011.01258.x
apa: Dileep, K. V., Tintu, I., Mandal, P. K., Karthe, P., Haridas, M., & Sadasivan,
C. (2012). Binding to PLA2 may contribute to the anti‐inflammatory activity of
catechol. Chemical Biology & Drug Design. Wiley. https://doi.org/10.1111/j.1747-0285.2011.01258.x
chicago: Dileep, Kalarickal V., Ignatius Tintu, Pradeep K Mandal, Ponnuraj Karthe,
Madathilkovilakathu Haridas, and Chittalakkottu Sadasivan. “Binding to PLA2 May
Contribute to the Anti‐inflammatory Activity of Catechol.” Chemical Biology
& Drug Design. Wiley, 2012. https://doi.org/10.1111/j.1747-0285.2011.01258.x.
ieee: K. V. Dileep, I. Tintu, P. K. Mandal, P. Karthe, M. Haridas, and C. Sadasivan,
“Binding to PLA2 may contribute to the anti‐inflammatory activity of catechol,”
Chemical Biology & Drug Design, vol. 79, no. 1. Wiley, pp. 143–147,
2012.
ista: Dileep KV, Tintu I, Mandal PK, Karthe P, Haridas M, Sadasivan C. 2012. Binding
to PLA2 may contribute to the anti‐inflammatory activity of catechol. Chemical
Biology & Drug Design. 79(1), 143–147.
mla: Dileep, Kalarickal V., et al. “Binding to PLA2 May Contribute to the Anti‐inflammatory
Activity of Catechol.” Chemical Biology & Drug Design, vol. 79, no.
1, Wiley, 2012, pp. 143–47, doi:10.1111/j.1747-0285.2011.01258.x.
short: K.V. Dileep, I. Tintu, P.K. Mandal, P. Karthe, M. Haridas, C. Sadasivan,
Chemical Biology & Drug Design 79 (2012) 143–147.
date_created: 2026-01-29T22:12:53Z
date_published: 2012-01-01T00:00:00Z
date_updated: 2026-02-20T08:20:52Z
day: '01'
doi: 10.1111/j.1747-0285.2011.01258.x
extern: '1'
external_id:
pmid:
- '21995306'
fulldoi: https://doi.org/10.1111/j.1747-0285.2011.01258.x
has_accepted_license: '1'
intvolume: ' 79'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1111/j.1747-0285.2011.01258.x
month: '01'
oa: 1
oa_version: Published Version
page: 143-147
pmid: 1
publication: Chemical Biology & Drug Design
publication_identifier:
eissn:
- 1747-0285
issn:
- 1747-0277
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Binding to PLA2 may contribute to the anti‐inflammatory activity of catechol
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 79
year: '2012'
...
---
OA_type: free access
_id: '21112'
abstract:
- lang: eng
text: Ester bond hydrolysis of membrane phospholipids by Phospholipase A2
and consequent release of fatty acids are the initiating steps of inflammation.
It is proposed in this study that the inhibition of phospholipase A2 is one of
the ways to control inflammation. Investigations are carried out to identify the
mode of inhibition of phospholipase A2 by the n‐hexadecanoic acid. It may help
in designing of specific inhibitors of phospholipase A2 as anti‐inflammatory agents.
The enzyme kinetics study proved that n‐hexadecanoic acid inhibits phospholipase
A2 in a competitive manner. It was identified from the crystal structure at 2.5Å
resolution that the position of n‐hexadecanoic acid is in the active site of the
phospholipase A2. The binding constant and binding energy have also been calculated
using Isothermal Titration Calorimetry. Also, the binding energy of n‐hexadecanoic
acid to phospholipase A2 was calculated by in silico method and compared with
known inhibitors. It may be concluded from the structural and kinetics studies
that the fatty acid, n‐hexadecanoic acid, is an inhibitor of phospholipase A2,
hence, an anti‐inflammatory compound. The inferences from the present study validate
the rigorous use of medicated oils rich in n‐hexadecanoic acid for the treatment
of rheumatic symptoms in the traditional medical system of India, Ayurveda.
article_processing_charge: No
article_type: original
author:
- first_name: Vasudevan
full_name: Aparna, Vasudevan
last_name: Aparna
- first_name: Kalarickal V.
full_name: Dileep, Kalarickal V.
last_name: Dileep
- first_name: Pradeep K
full_name: Mandal, Pradeep K
id: 6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
last_name: Mandal
orcid: 0000-0001-5996-956X
- first_name: Ponnuraj
full_name: Karthe, Ponnuraj
last_name: Karthe
- first_name: Chittalakkottu
full_name: Sadasivan, Chittalakkottu
last_name: Sadasivan
- first_name: Madathilkovilakathu
full_name: Haridas, Madathilkovilakathu
last_name: Haridas
citation:
ama: 'Aparna V, Dileep KV, Mandal PK, Karthe P, Sadasivan C, Haridas M. Anti-inflammatory
property of n-hexadecanoic acid: Structural evidence and kinetic assessment. Chemical
Biology & Drug Design. 2012;80(3):434-439. doi:10.1111/j.1747-0285.2012.01418.x'
apa: 'Aparna, V., Dileep, K. V., Mandal, P. K., Karthe, P., Sadasivan, C., &
Haridas, M. (2012). Anti-inflammatory property of n-hexadecanoic acid: Structural
evidence and kinetic assessment. Chemical Biology & Drug Design. Wiley.
https://doi.org/10.1111/j.1747-0285.2012.01418.x'
chicago: 'Aparna, Vasudevan, Kalarickal V. Dileep, Pradeep K Mandal, Ponnuraj Karthe,
Chittalakkottu Sadasivan, and Madathilkovilakathu Haridas. “Anti-Inflammatory
Property of n-Hexadecanoic Acid: Structural Evidence and Kinetic Assessment.”
Chemical Biology & Drug Design. Wiley, 2012. https://doi.org/10.1111/j.1747-0285.2012.01418.x.'
ieee: 'V. Aparna, K. V. Dileep, P. K. Mandal, P. Karthe, C. Sadasivan, and M. Haridas,
“Anti-inflammatory property of n-hexadecanoic acid: Structural evidence and kinetic
assessment,” Chemical Biology & Drug Design, vol. 80, no. 3. Wiley,
pp. 434–439, 2012.'
ista: 'Aparna V, Dileep KV, Mandal PK, Karthe P, Sadasivan C, Haridas M. 2012. Anti-inflammatory
property of n-hexadecanoic acid: Structural evidence and kinetic assessment. Chemical
Biology & Drug Design. 80(3), 434–439.'
mla: 'Aparna, Vasudevan, et al. “Anti-Inflammatory Property of n-Hexadecanoic Acid:
Structural Evidence and Kinetic Assessment.” Chemical Biology & Drug Design,
vol. 80, no. 3, Wiley, 2012, pp. 434–39, doi:10.1111/j.1747-0285.2012.01418.x.'
short: V. Aparna, K.V. Dileep, P.K. Mandal, P. Karthe, C. Sadasivan, M. Haridas,
Chemical Biology & Drug Design 80 (2012) 434–439.
date_created: 2026-01-29T22:14:04Z
date_published: 2012-09-01T00:00:00Z
date_updated: 2026-02-20T08:23:29Z
day: '01'
doi: 10.1111/j.1747-0285.2012.01418.x
extern: '1'
external_id:
pmid:
- '22642495'
fulldoi: https://doi.org/10.1111/j.1747-0285.2012.01418.x
has_accepted_license: '1'
intvolume: ' 80'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1111/j.1747-0285.2012.01418.x
month: '09'
oa: 1
oa_version: Published Version
page: 434-439
pmid: 1
publication: Chemical Biology & Drug Design
publication_identifier:
eissn:
- 1747-0285
issn:
- 1747-0277
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: 'Anti-inflammatory property of n-hexadecanoic acid: Structural evidence and
kinetic assessment'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 80
year: '2012'
...
---
OA_type: closed access
_id: '21151'
abstract:
- lang: eng
text: The decanucleotide sequence d(CCGGTACCGG) crystallizes as a four-way junction
at low cobalt ion concentrations (i.e., 1 mM). When the cobalt concentration in
the crystallization solution is increased to 5 mM, the sequence crystallizes as
resolved B-DNA duplexes. Gel retardation studies of the decamer show both a faint
slow-moving band and a much thicker fast-moving band at low cobalt ion concentrations,
and only the intense fast-moving band at higher ion concentration. Circular dichroism
(CD) spectroscopy of the decamer indicates a structural transition as the cobalt
ion concentration in the solution is increased, probably from B-type to A-type
DNA. These studies revealed that the oligomer sequence has several conformations
and structures accessible to it, in a manner dependent on sequence, ion concentration,
and DNA concentration.
article_processing_charge: No
article_type: original
author:
- first_name: S.
full_name: Venkadesh, S.
last_name: Venkadesh
- first_name: Pradeep K
full_name: Mandal, Pradeep K
id: 6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
last_name: Mandal
orcid: 0000-0001-5996-956X
- first_name: N.
full_name: Gautham, N.
last_name: Gautham
citation:
ama: Venkadesh S, Mandal PK, Gautham N. Crystallographic and spectroscopic studies
of d(CCGGTACCGG). Nucleosides, Nucleotides and Nucleic Acids. 2012;31(3):184-196.
doi:10.1080/15257770.2011.648363
apa: Venkadesh, S., Mandal, P. K., & Gautham, N. (2012). Crystallographic and
spectroscopic studies of d(CCGGTACCGG). Nucleosides, Nucleotides and Nucleic
Acids. Informa UK Limited. https://doi.org/10.1080/15257770.2011.648363
chicago: Venkadesh, S., Pradeep K Mandal, and N. Gautham. “Crystallographic and
Spectroscopic Studies of d(CCGGTACCGG).” Nucleosides, Nucleotides and Nucleic
Acids. Informa UK Limited, 2012. https://doi.org/10.1080/15257770.2011.648363.
ieee: S. Venkadesh, P. K. Mandal, and N. Gautham, “Crystallographic and spectroscopic
studies of d(CCGGTACCGG),” Nucleosides, Nucleotides and Nucleic Acids,
vol. 31, no. 3. Informa UK Limited, pp. 184–196, 2012.
ista: Venkadesh S, Mandal PK, Gautham N. 2012. Crystallographic and spectroscopic
studies of d(CCGGTACCGG). Nucleosides, Nucleotides and Nucleic Acids. 31(3), 184–196.
mla: Venkadesh, S., et al. “Crystallographic and Spectroscopic Studies of d(CCGGTACCGG).”
Nucleosides, Nucleotides and Nucleic Acids, vol. 31, no. 3, Informa UK
Limited, 2012, pp. 184–96, doi:10.1080/15257770.2011.648363.
short: S. Venkadesh, P.K. Mandal, N. Gautham, Nucleosides, Nucleotides and Nucleic
Acids 31 (2012) 184–196.
date_created: 2026-02-06T12:10:42Z
date_published: 2012-03-01T00:00:00Z
date_updated: 2026-02-20T08:17:42Z
day: '01'
doi: 10.1080/15257770.2011.648363
extern: '1'
external_id:
pmid:
- '22356234'
fulldoi: https://doi.org/10.1080/15257770.2011.648363
has_accepted_license: '1'
intvolume: ' 31'
issue: '3'
language:
- iso: eng
month: '03'
oa_version: None
page: 184-196
pmid: 1
publication: Nucleosides, Nucleotides and Nucleic Acids
publication_identifier:
eissn:
- 1532-2335
issn:
- 1525-7770
publication_status: published
publisher: Informa UK Limited
quality_controlled: '1'
status: public
title: Crystallographic and spectroscopic studies of d(CCGGTACCGG)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 31
year: '2012'
...
---
OA_type: closed access
_id: '21153'
abstract:
- lang: eng
text: "Curcumin possess anti-inflammatory activity. In this study, the binding of
curcumin with PLA2 was studied using X-ray crystallography. Since the electron
density found at the active site did not match with curcumin, 2-methoxycyclohexa-2-5-diene-1,4-dione
(MCW) (the photodegraded product of curcumin) was fitted in the unexplained electron
density. To understand the binding mode of actual curcumin, molecular docking
study was carried out. The crystallographic and docked structures were superimposed
with respect to the ligand position and it was found that curcumin was binding
in the hydrophobic cavity of PLA2 with a binding energy of−16.81 Kcal/mol. The
binding mode was of such a nature that it prevented the entry of the substrate
to the hydrophobic active site. This study indicates that curcumin can act as
an inhibitor of PLA2.\r\n\r\nAn animated Interactive 3D Complement (I3DC) is available
in Proteopedia at http://proteopedia.org/w/Journal:FLS:1."
article_processing_charge: No
article_type: original
author:
- first_name: K. V.
full_name: Dileep, K. V.
last_name: Dileep
- first_name: I.
full_name: Tintu, I.
last_name: Tintu
- first_name: Pradeep K
full_name: Mandal, Pradeep K
id: 6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
last_name: Mandal
orcid: 0000-0001-5996-956X
- first_name: P.
full_name: Karthe, P.
last_name: Karthe
- first_name: M.
full_name: Haridas, M.
last_name: Haridas
- first_name: C.
full_name: Sadasivan, C.
last_name: Sadasivan
citation:
ama: Dileep KV, Tintu I, Mandal PK, Karthe P, Haridas M, Sadasivan C. Crystal structure
of porcine pancreatic phospholipase A2 in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione.
Frontiers in Life Science. 2012;5(3-4):135-139. doi:10.1080/21553769.2012.689262
apa: Dileep, K. V., Tintu, I., Mandal, P. K., Karthe, P., Haridas, M., & Sadasivan,
C. (2012). Crystal structure of porcine pancreatic phospholipase A2 in complex
with 2-methoxycyclohexa-2-5-diene-1,4-dione. Frontiers in Life Science.
Informa UK Limited. https://doi.org/10.1080/21553769.2012.689262
chicago: Dileep, K. V., I. Tintu, Pradeep K Mandal, P. Karthe, M. Haridas, and C.
Sadasivan. “Crystal Structure of Porcine Pancreatic Phospholipase A2 in Complex
with 2-Methoxycyclohexa-2-5-Diene-1,4-Dione.” Frontiers in Life Science.
Informa UK Limited, 2012. https://doi.org/10.1080/21553769.2012.689262.
ieee: K. V. Dileep, I. Tintu, P. K. Mandal, P. Karthe, M. Haridas, and C. Sadasivan,
“Crystal structure of porcine pancreatic phospholipase A2 in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione,”
Frontiers in Life Science, vol. 5, no. 3–4. Informa UK Limited, pp. 135–139,
2012.
ista: Dileep KV, Tintu I, Mandal PK, Karthe P, Haridas M, Sadasivan C. 2012. Crystal
structure of porcine pancreatic phospholipase A2 in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione.
Frontiers in Life Science. 5(3–4), 135–139.
mla: Dileep, K. V., et al. “Crystal Structure of Porcine Pancreatic Phospholipase
A2 in Complex with 2-Methoxycyclohexa-2-5-Diene-1,4-Dione.” Frontiers in Life
Science, vol. 5, no. 3–4, Informa UK Limited, 2012, pp. 135–39, doi:10.1080/21553769.2012.689262.
short: K.V. Dileep, I. Tintu, P.K. Mandal, P. Karthe, M. Haridas, C. Sadasivan,
Frontiers in Life Science 5 (2012) 135–139.
date_created: 2026-02-06T12:17:45Z
date_published: 2012-08-06T00:00:00Z
date_updated: 2026-02-20T08:07:19Z
day: '06'
doi: 10.1080/21553769.2012.689262
extern: '1'
fulldoi: https://doi.org/10.1080/21553769.2012.689262
has_accepted_license: '1'
intvolume: ' 5'
issue: 3-4
language:
- iso: eng
month: '08'
oa_version: None
page: 135-139
publication: Frontiers in Life Science
publication_identifier:
issn:
- 2155-3769
- 2155-3777
publication_status: published
publisher: Informa UK Limited
quality_controlled: '1'
status: public
title: Crystal structure of porcine pancreatic phospholipase A2 in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2012'
...